Toggle navigation
TopoIBase
Data
Taxonomy and VLD families
Downloads
My selection
Upload to selection
Selection 1
Selection 2
Selection 3
Tools
Blast
MUSCLE
VLD
About
How to use
Acknowledgements and references
Contact
Tests
Search more
Download
fasta
tsv
Download
Blast
Muscle
VLD
Add to selection
Selection 1
Selection 2
Selection 3
All selections
Family 1
Informations
Name
1
# topoisomerases
668
Sub-families
No subfamilies.
Topoisomerases
Select all
Name
Family
Sequence
(1) DNA topoisomerase 1 [Owenweeksia hongkongensis DSM 17368]
1
MPKNLVIVESPAKAKTIEKYLGKDYQVESSYGHIRDLVKKDMGIDVENNFAPSYAISSDKKEVVKKLKALAKKADTVWLASDEDREGEAIAWHLAEALGLNTLTTNRIVFHEITKGAIERAIQNPRTIDQNLVDAQQARRILDRLVGYELSPVLWKKVRAGLSAGRVQSVAVRLIVEREREIQNFESTSYFRVAAIFSNKEGKSFKAELNKRFDTEKEAKDFLEKCKSYKFSIGDIDTKPAKKSPAAPFTTSTLQQEAARKLYFNVGQTMSVAQRLYESGQITYMRTDSVNLSDEAMSLAENEIKKSYGKEYAKRRKYSNKSKGAQEAHEAIRPTDMSKHSGGADDQQRKLYDLIWKRTLASQMSDAQLERTVLKIETPEEKLEFVARGEVIKFEGFLKVYLEGTDDEDVEEQEGMLPAMSKGESLDNDNIIATQRFTQHPPRFTEASLVKKLEELGIGRPSTYAPTISTIQKREYIQKSDLEGTKRNYTQLILKDSKIAEKTLSETTGADKNKLMPTDIGSVVNDFLVEHFKKVLDYNFTAKVEAQFDEIASGNEKWAQMIDEFYSDFHPHLKDVEENSERASGERLLGQDPESGKNVYARIGRFGPMVQIGEADNEEKPKFASLQKTQSIDTITFDEAMDLFQLPRTLGEYKGEEIQANVGRFGPYVKFGDKFISLDKGENPMDTTLDRAIELIVAKEKADAPIAEYENLPVQKGVGRFGPFIKWNGIFINVNKKYDFDNLTQANIEELIEDKKKKEREKVIHNWEDAGIRLEKARWGRFNLIKGKVKVELPKTTDAAAFTLEEAESIIEKNAPKKKAKPKAKTKAAPKKSRAKK
(2) DNA topoisomerase 1 [Pedobacter heparinus DSM 2366]
1
MAKNLLIVESPAKAKTIEGYLGKDFLVKSSYGHIRDLVKGDMAIDTANNFAQTYEVPSDKKQVVAELKKLAKDAEMVWLASDEDREGEAISWHLYETLGLKENKTKRIVFHEITKPAILKAIETPRSIDYNLVNAQQARRVLDRLVGFELSPVLWKKIKPSLSAGRVQSVAVRLIVDREREVNKFNAAAAFKITAEFVTGNGKELVKAELPQRFEKEADAEKFLNDCAGAGFSVDSLETKPAKRNPAAPFTTSTLQQEASRKLGYSVSRTMQIAQRLYESGRITYMRTDSVNLSETALQAAASEIRSAWGDKYHQPRTYKTKSAGAQEAHEAIRPTYFNQHTVPGDSSEQRLYELIWKRAIASQMSEALFEKTTAQIGISTRKEQLIAEGEVLKFDGFLKVYLESSDEEDAEDSEGNNMLPALSRGQALTLKVMNATERFSRPPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVVKEDRDGRQRSFAAIELSNGSVTKKTKTEITGAEKGKLFPTDIGEVVNDFLVEHFKGIVDFNFTANVEKEFDEIAQGLQEWTKMLHSFYTPFHLEVENTLETADRANGERLLGLDPATGKNVYTKVGRFGPLVQIGENDDEEKPRYASLSKSQSVGTVTLEEALEQFKLPFSLEDYQGKEVSVGVGRFGPYVKWGDAFISVPKNEDPLSIDQARAIEIIGEKITADAPVAHYQGMPVTKGTGRFGPFIKWNDLFINVPKAYNFDRLSQQDIEELIGKKIEKEANRFIQQWPAEKIAIENGRWGPFIRFGKEMLKLRKNPATNDKYTPEELASIALDEVKKLIVEQVPNAFEPKKKAAAKKTGAAKKAPAKKKAVAKK
(3) DNA topoisomerase 1 [Oenococcus oeni PSU-1]
1
MVTKKKKAKKLVIVESPAKARTIENYLGRDYEVLASMGHIRDLPKSQLGVDTEHNYEPKYINIRGKAPLINSLKKAAKSASAVYVASDPDREGEAIAWHLGHILGLPDGGKNRVTFNEITKPAVKEAFKHPRGIEQDLVDAQQARRVLDRLVGYSISPILWQKVKRGLSAGRVQSVALGLILDKEKEIAAFVPKEYWSLNANFKAGKHEFSAEFYGTDGKKVKLDNQKSVSKILKRIDSSKDFKITDISTKESKRNAPNPFTTSSLQQTANSQLNYHARKTMQIAQGLYEGISLPKIGHVGLITYMRTDSTRLSETAQEMAKKFIVDKFGKEYYHRHNVVKKSENVQDAHEAIRPTDAERTPESLKEILTRDQYRLYNLIWSRFIASQMSEQKLENQSLMIEQNKTVWRATGIKVLFEGWTMALKTSSTKNNILPALKIGDLVQMVNNLPEQHFTQPPARYTEASLIKALEELGVGRPSTYAPTMDTIQRRGYIGFDQKKIVPTDLGDIVQDVVVKSFPEVTDKQFTSKIEDELDKVETGNVKWQKVIDEFYKPFSKEVDAAIENLEKVPIYDRIAPELCDICGSLMVIRRSRRGEFYACSRFPDCHGTKSIVEEIGMKCPKCGIGEVVIKRTKRGRIFYGCSRYPDCDFASWTKPKKNEETEENNETK
(6) DNA topoisomerase 1 [Borrelia burgdorferi B31]
1
MQNKKLIIVESPTKAKTIKKFLDESFLVEACIGHVVDLPNNAKEIPKEYKKYEWANISIDYNNGFNPIYIIPSNKKPIVSKLKKLVKTINEIYLATDQDREGETIAFHLKEVLKIKNYKRMIFHEITETAITESLKNTRNIDMNLVNAGEARRILDRLYGYTISPLLWKKVAYGLSAGRVQSVGLKLLIEKEKTRINFKKANYYSILLQCKHEKKNLLLEAKLEEIDGKNIAEGKDFVNETGKLKNIAKTTIITQDLMIELEKELKNGQKIELISIETKKIKIPPPKPFTTSTLQQEINKRLKIGTKQIMQHAQKLYEHGYITYMRTDSHNIAKIAKDKITKIIKNKYGKEYIEEKDRIYEKEKMAQNAHEAIRPSEIFIPNETIEIESKTAKEIYKIIWDRTIISGMKDAIKENIKLTFKYKNLIFRSSFTKIIFDGFLKHTKEQDEHLNINFDLIKKGDTFSIVKMKTSEHETKAPFRYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNTLMPTIKGAAVINLLEKYFPVLIELNFTSNMEEKLDKIAIGKLDKIKYLSKFYNGKKGLKDTVMQLEPKIDSSEFRTVIESQKIENKNSINYTINIGKYGPYLIFKGHNYSINAKTPLENLYKKDEIEKIINEKELKPNILGVDPLTGLNVIFKNTIYGNIVQLGEDTHAPQEYTKKGKPKKLKIIKAKKASTKKIDPENITLELALKLLSLPKPIGKHPQTNEQIIAATGVFGDYIKTESGSIACSLKKDLKAYDITLDKAISLLNERANKVGIIVKTITFSKNKIGNKIYIYKKNDKFYAKIKRKKIDLPDNINLEEINEKYVFSLL
(8) DNA topoisomerase 1 [Porphyromonas asaccharolytica DSM 20707]
1
MANQKNLVIVESPAKAKTIGKFLGADYKVLSSYGHIRDLKPSSFSVDVEHHFAPIYEIPADKQRLVSELRKAAKGSDIVWLASDEDREGEAIAWHLYQVLDLKDKETHRIAFHEITKSAIQHAIQNPRSINENLVDAQQARRVLDRIVGFELSPVLWRRVGPSLSAGRVQSVAVRLIVEREREILAFQPETSFAITTRLETKGGDTFSATLPENLPSEEAARQLMQRAIDSQSTFAVQQVEQKPGRRSPSAPFTTSTLQQEASRKLGMSVSNTMRVAQALYERGLITYMRTDSVNLSSLALHDAETVILEQWGADYYQRRHYHAKSKGAQEAHEAIRPTYLRNATIQGTKQEQALYDLIRKRTLASQMADARIERTIAQIASQGADSVRLEARGEVIVFDGFISAYTESRDDEEDTSGNVLPKLREGDSLQLREIEGRQSFTKPKPRYTEASLVRKMEELGIGRPSTYAPTIQTIQNREYVRRGESQGESRDVLYLNWQHGAGNTTIKSHKQKERYGGDRGRLVPTDMGIVVTDFLMENFSRVVDYNFTADVEEHFDKVAEGEAHWQDLIGTFYDKFHPIIEEQSQSGAKRYTGERLLGTDPVSGKPVIARIGRYGPMVQIGEAPDSSLPEEERERLKPRFASIPSNLLIETITLEEALKLFDLPRTVGEFEGGDVVAAVGRFGPYLRHKGAFTSIPKSSGLTPEEITLQEAIELIEEKRRKDAASLLKSFPEDPDIVIRDGRWGAYIKVGKKNYKLTKEQKAEPTKLTYAEVVAIIAEQDNETPKKGRATAKKATSTSKKSTTKKTTSTAKKAAPKRSAASKS
(9) DNA topoisomerase 1 [Desulfotomaculum kuznetsovii DSM 6115]
1
MSKTLVIVESPAKAKSIGKLLGKKYTIKASMGHVRDLPKSQFGVDVEHGFTPKYITIRGKGEIIKELRTAVKKADRVLLASDPDREGEAIAWHLANVLEIDENAPCRIEFNEITKQAVQNAVKAPRPIDYNRVNAQQARRILDRLVGYKLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEINAFVPEEYWTLTAVFTRRGKDPFEAKLYKIGDKKAEIKNQAQIEEILKELKGVSYRVVKITRREKTRQPAPPFTTSSLQQEAYRKLNFTARKTMMVAQQLYEGLELGKEGPVGLVTYIRTDSTRVAVQAQMDARAYIQEKFGPGYVPEKPRQVAARGRAQDAHEAIRPTAVEREPEAIKQYLTPDQYKLYKLIWSRFVASQMSPAIIETTSIDITGGHYTFRAAGSVVKFPGFTRVYVESRDDETKEEEGVLPALSEGEALEVKSLTPKQHFTQPPPRYTDATLVKALEEKGIGRPSTYAPILETIIKRGYVVREKKQLVPTELGMVVVDLLKKHFPDIIDVEFTAQMEESLDRIEEGEMDWVRVIQDFYGPFQETLARAEEEIGQVTVSDEVSEEICEQCGRNMVVKMGRYGKFLACPGFPECRNTRPLLEPTGVPCPQCKGELVVRRSKKGRKFYGCSRYPDCDFVVWDEPSGEKCPRCGGILVIKKGRGEQEELECVNEQCRYRVDREKKAGSNGEAARDVAAGSKLVEEKPSFDSWHNDALLPLMRAKSGRTATRGTGGRS
(17) DNA topoisomerase 1 [Bacteroides fragilis NCTC 9343]
1
MQKNLVIVESPAKAKTIEKFLGKDFKVLSSYGHIRDLKKKEFSIDIEKNFKPKYEIPAEKQELVNKLKEEASKAETVWLASDEDREGEAISWHLYEVLKLKPENTKRIVFHEITKTAILKAIEQPRDIDINLVNAQQARRILDRIVGFELSPVLWKKVKPALSAGRVQSVAVRLIVEREREIQAFKSEASYRVTAVFLVPDADGKLVEMKAELARRLKTKKEAQKFLESCKAATFSIEDIVTRPVKKSPAAPFTTSTLQQEAARKLGFTVAQTMMVAQKLYESGLITYMRTDSVNLSEYATEGSKVAIAQMMGDQYVHPRHFATKTKGAQEAHEAIRPTYMENQTIEGSAQERKLYDLVWKRTIASQMADAELEKTTATIGISNGNDKFTATGEVIKFDGFLRVYKESYDDDNEQEDESHLLPPLKKGQMLEHQGIVATERFTQRPSRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVEKGDKPGEERSFDILTLKDNQITDIKHTEIVGAEKSKLLPTDIGTVVNDFLTEYFPNILDYNFTANVEKQFDEIAEGDKKWTSIMKDFYKDFHPSVETTLATKTEHKVGERILGEEPKTGKPVSVKIGRFGPVVQIGTADDTDKPRFAQMKKGQSMETITLEEALDLFKLPRKVGEFEDKTVTIGTGRFGPYVYHNSKYVSLPKTYDPLEVTLDEAIELILAKREAEAKKHIKKFDEDAEMEILNGRYGPYIAYKGNNYKIPKDVVPVDLNYQTCLEIIKLQSEKAENAPKRGRYAKKK
(19) DNA topoisomerase 1 [Deinococcus maricopensis DSM 21211]
1
MSTLVIVESPSKAKKIQAYLGAGYTVRASLGHIRDLPASKADIPARYAAEPWARLGIHVQDSFRPLYVISRGKAKVVRELRELARGANRVLLATDPDREGEAIAWHLMVALGLKGSVERMTFHEITREAIQAAARATRPLDYALVGAQEARRTLDRLVGYGVSPTLWTAVGPKLSAGRVQSAALAALAAREHARMAFVPADYWRVTARVGAGRPFTAVVLSVNGQRLATPKDFDAGTGQLAADALLMTPEQADRLVAFLRARDATVTGVERAPYTSRPPAPFTTSTLQQEASKALKFSPKHSMDVAQRLYENGFITYMRTDSPALSDEALQAAREAATALFSEGSVPARPRTYAARGANAQEAHEAIRPAGRSFRAPDDTPLTGDERALYDLIYRRTVASQMTDLTGTRTVMHLKVGAVALGATGRVVHDPGFTRLYQDASEGDGDETQALPDAEVGAVLPVRDAAAEERKTPAPGRFTEASLVRALERAGVGRPSTYASILSTLDARGYTRVVRRQLTVTWVGLLVSAYLAGSFADLVDAGFTASMEADLDRIAGGALTREAYLTRFWSEGLAGTIGRAGRAAPVLTVPRVPGATVTVQDGTPLLRLHGRSAPLPADLVPDDLTPDVAEQVLNGERKAAQRASGGKRARSGGARTSRARSSRKAARPK
(20) DNA topoisomerase 1 [Pseudovibrio sp. FO-BEG1]
1
MESPAKAKTINKYLGKDYTVLASYGHVRDLPPKDGSVLPDDDFAMSWSVDSKSQKRLSDIASAVKEADRLILATDPDREGEAISWHVLEVLKKKRVLKDKKVERVVFNAITKSSILEAMKNPRELDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCQRENEIETFLSQEYWSILANLNTPENAPVQARLTGFDGQKITRLDIKNEQEATTIKQMLDGANFSVSNVESKPQRRNPYAPFTTSTLQQEASRKLGFAAARTMQVAQKLYEGANIGGETTGLITYMRTDGVQIAPEAITSARGVIASRYGDEYVPEKPRMYSSKAKNAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIWKRTIASQMESAVLERTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESKRLPPMTRGDSLGRKGIEANQHFTEPPPRFTEATLVKKMEELGIGRPSTYAATLQTLRDRGYVELDKKRLIPQDKGRLVTAFLEDFFNRYVEYDFTASLEDQLDKISAGDLEWKAVLRDFWNPFHEICDEVIKRSNTEVLDALNETLKAHVFPDKEDGSDPRKCPKCDTGRLSLKVSRFGAFVGCSNYNKDKKDGKEPNENPPHCDYTRQLTSGGDSDAGAAADGPQVLGIDPETGLEVSLRTGRFGPYVQLGEEAKPKRSSLPRGWSTADLDLEKALQLLSLPREVGTHPEDGKTISAGLGRFGPFVLHDGTYANLDSPDEVFSVGINRAVTLLAEKRAKGGGRGAAAKPLKELGNHPDGGAINVYSGRYGPYVKWEKINATLPKDVAPEAVTLEQAIELVNAKAATKGKKKAPAKKAAAKKTTAKKAAPKGALKEFGDHPDGGAMELRDSGRLGVRIKWGKEFVSLPKGTDPETVTREQAIELINAKKG
(21) DNA topoisomerase 1 [Chlamydophila pecorum E58]
1
MSRQIQFMKKSLIIVESPAKIKTLKKFLGGNFVFASSIGHVVDLPAKEFGIDVDHDFEPLYQVLPEKQEVIRQIQKLAEQCDKVYLSPDPDREGEAIAWHIANQLPAHLSVQRVSFNAITKRAVTEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIQVLLQDPKTKKSFWAHLYSVEGKKLEKELPKEKTENDVLLINSKERAQKYADLLESASYKVVRIEAKEKRRHALPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGIDINEDTVGLITYMRTDSVRVDPEALHSVRSYIHTAFGSEYLPEKANVYSTKKMTQDAHEAIRPTDIHLSPESLAGKLSEDQHKLYSLIWKRFVASQMAPAIYDTLAVQISTDVHIDLRASGSLLKFKGFLVVYEEKSDDENDQEDLHPLPPLHAQDLLNKERVSAEQAFTRPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWEQFLPVVTTAEKEAVIPRITTDIECPKCHQGKLIKIWSKNGYFYGCSAYPDCDHRTSEEELSFKKEDYAADTPWDSPCPICQSPMKVRHGRYGSFLGCENYPTCRGTITLRKHGEEAEQEDPVPCPALGCSGKLLKKRSRYNKNFYSCSEYPHCSVIGNSIDAVLTKYTGTPKTPYEKKPSKKEAKKSTKTIKKAPAVKKASASTKNSPLLVPSPALASMIGDAPLSRGEATKKVWEYIKAHNLQSPENKKLLLPDEKFSAIIGNAPIDMFALPKLLSAHLKKKEG
(23) DNA topoisomerase 1 [Bradyrhizobium japonicum USDA 6]
1
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDANFKMIWEVDPKAAGRLNDIAKSLKGADRLILATDPDREGEAISWHVLEVLKEKRALKDQKIERVVFNAITKQAVTDAMKNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVPREYWSLIATLLTPRGDAFEARLVGADGKKIQRLDVGSGAEAEDFKKALEAAAYAVTAVDAKPARRNPQAPFTTSTLQQEASRKYGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDPSAITQARKVIGEDYGNAYVPEAPRQYQAKAKNAQEAHEAIRPTDMSRRPDSMSRKLDADQARLYELIWKRTIASQMESAELERTTVDITAKAGSRTLELRATGQVVKFDGFLALYQEGRDDEEDEDSRRLPAMSPNDALKRQSLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLHGEDKGRVVVAFLESFFNRYVEYDFTANLEEQLDRISNNEISWQQVLKDFWTGFIGAVDEIKDLRVAQVLDVLDDMLGQHIYPPRADGGDIRQCPSCGNGRLNLKAGKFGAFVGCSNYPECRYTRQLAADSETTADRSLGQDPDTGRDVWVKAGRFGPYIQLGEPKDYEEGEKPKRAGIPKGTSPGDVELELALKLLSLPREIGKHPETGQPITAGLGRFGPFVKHEKTYASLESGDEVFDIGLNRAVTLIAEKVAKGPSRRFGADPGKAIGDHPTLGTVTVKSGRYGAYVTAGGVNATIPAEFEKDTVTLPQAIALIDERAAKGGGKTKAKKAAKPAKAKKAAEKAADGDDAAPKPKKPAAKKAAKPKSESTSKARAAVSSTAKTSPTKAAAPKAPAKKSAGKT
(24) DNA topoisomerase 1 [Desulfurivibrio alkaliphilus AHT2]
1
MGKSLIIVESPAKARTLQKHLGKDYLVKASVGHIRDLPVSSLGVDIDHDFAPQYVTIKGKAKVISDLKKAAKEADQVYLAPDPDREGEAIAYHIAEALKTTRKPIRRVLFHELTHKAVLAALEKSGEVDHHLFEAQQARRVLDRLVGYQISPLLWDKVRRGLSAGRVQSVAVRMVCEREEEIEKFVSEEYWSITTTLAGPQPPPFQALLEKVDGRKLDNRKRKIADEAQARELVLQLMAAELKVAGVDKKQQRRRPSPPFITSTMQMDANRKLRFSAKKTMAQAQRLYEGIDLGKEGPVGLITYMRTDSTRVNDEALGMARDYIGSTYGADYLPAKPVQYKTGKGAQDAHEAIRPTDVSRTPESLAGKLDKDMLALYTLIWKRFVASQMAPAIYDQTSIRIAGGPEGRHELKATGSIMRFPGFMTLYVEAVDETPEEGKQSGKGGKDALLPDLQEGQLLKLNEITPKQHFTQPPPRYTEATLVKALEENGVGRPSTYAAILSTIVDKEYVRLTQRKFYPTDLGRMVNKLLVAHFPKVIDTDFTAKLEQELDEIETGKVDWVQVMREFYGPFQQNLEQAREEMKAVKHSAIPTGLNCPQCESELVIKWGRKGEFLACSNYPECKHTQDFTRDEEGKIKPLEREAPEESGESCDKCGKPMVYKHGRFGKFLACSGYPDCKNVRAISTGVSCPEDGCDGEIVQKVSKRGKVFYSCNRYPKCTYALWDKPVAKPCPLCSSPFLVEKSSKKGRRLACPNKECRYSEELPEEGE
(31) DNA topoisomerase 1 [Xanthomonas campestris pv. campestris str. ATCC 33913]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNGFAMRYDLIEKNEKHVEAIARAAKSADDIYLATDPDREGEAISWHIAEILKERGLLKDKTMQRVVFTEITPRAIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIDAHCRHPSQPFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALAEIRDVIARDFGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVAGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTANLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGADPVSGKEVSARIGRFGPMVQIGTVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKEFDGSDIQVLNGRFGPYISDGKLNGKIPKDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVKDSAKEAKDAAKKTAAVKKVATKTAAKKAPAKKAAKKATKRVVKKAVSKAAG
(36) DNA topoisomerase 1 [Ruegeria sp. TM1040]
1
MPVVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPAKNGSVDPEDDFAMTWEVGNDSKKHVRAIAEALKDDNALILATDPDREGEAISWHLQEALTKRRSIKKDTDVKRVTFNAITKDAVAEAMKNPRDVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVCLRLIVEREMEIEAFNPQEYWSVRANLATPRGQSFEARLTVLGGEKLDKFSLANSTAAELAVQAVSSRKMSVLSVEAKPAARNPSAPFMTSTLQQEASRKFGMGAKQCMNAAQRLYEAGLITYMRTDGIDMAPEAVSAARDEIAKRYGQEYVPGEPRIYKNKAKNAQEAHECIRPTDMSRDAASLKVSEDDQRKLYDLIWKRTLACQMAGARLERTTVDIGSDDKQVVLRATGQVVMFDGFMRVYEEGRDDVVDEDDKRLPQIMQGEALKFAGSLAAQAEKAGKDGSVLSQDGATLALQHHTQPPPRYTEATLVKRMEELGIGRPSTYASVITTIQDREYVRKDKNRLFPEDKGRIVTIFLLNFFKRYVEYDFTAALENQLDDVSAGGKDYKELLDSFWRDFSAAISETSDLRISEVLDVLDEALAPQLYPPREDGGDPRICPKCGAGQLHLKTSRTGGFVGCGNYPECNYTRPISGEGAEGYERVLGEDDGDEIHLKSGRFGPYVQRGEATPENKKPPRSSLPKQGKDYLPGWGPNEITLEQAVTLLTLPREIGAHPEGGVVSSNLGRFGPYIMHQRPDEEKPVYVNLKETLDVFEIGMNRAVEMLAEKRANPGRGRSAAAKPLRELGEHPDDKAPVNIMDGRYGPYVKWGKVNATLPKDTEAKDVTMEMAVELLNEKAAKSGKKKAPAKKAAAKKTTAKKTTAKKAPAKKKEAKASGD
(38) DNA topoisomerase 1 [Bartonella tribocorum CIP 105476]
1
MNIVIVESPAKAKTINKYLGPQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDIDSAAAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDVLRQKKVLKDKPIKRVVFNAITKKSVLDAMNNPRDIDTSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTQLKTIRNDHFQARLTMFNQRKIGKLDIQSQEQADQIRLMLEKAQYHTLSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEVAGLITYMRTDGVQIAPEAIDAARKVIHESFGKDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRSPNQVRNFLDDDQAKLYELIWKRAIASQMCSAEIERTTVEIEAQQGDNRANLRATGSVVRFDGFISVYTDQRDEENNEENETTRLPQINTGEALTKEKVESLQHTTEPPSRYSEASLIKKLEELGIGRPSTYASTLATLCDRGYIVIDKRKLIPDAKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRDFWDGFNTSISNIQELRIANVLDVLNVTLAPLAFPEREDGSDVRSCPLCKNGQLSLKLGRYGAFVGCSNYPECRYTRQLGTTDTEEENEAVRNDEPVMLGIDPETGKDISLRNGRFGPYIQRGESKEVKRAGLPKEWQAENITLERALALLSLPREIGIHPETGKMITATIGRYGPYLSHNGKSARLLHADEVFDIGINRAVTVLAEQQENKTKQSRTTSAALATLGEHPEGGTVTVRNGRYGPYVNWGKINATLPKEKDPISVTLSEALELISAKASSKKAISKRASSKTKAKTKET
(39) DNA topoisomerase 1 [Listeria seeligeri serovar 1/2b str. SLCC3954]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLDLDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVNGKKKKLSTADDVKEVMSTIKGKTFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEAGNYIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSAMRSPQAVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVKTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFIPTELGEIVNEMIEEYFPEILDVKFTANMESELDEVEHGQVEWVKVIDEFYKQFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVFKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERVCPKCNERALVEKKLKKGVQVQCTNCDYKESTQQ
(45) DNA topoisomerase 1 [Gluconacetobacter diazotrophicus PAl 5]
1
MTDVVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDENFAMDWQADERGSRQMAAIAKALRGARHLYLATDPDREGEAISWHVRAMLEEKNLLKGVDVQRVTFNEITKSAIRAAMAQPRDLDQPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIESFRAREYWTVAAQFTTPGGAAFTARLTHLAGRKLDQFDLHDEAGAMAAKAAVEAGRFAVQSVERRKVRRNPPPPFTTSTMQQEASRKLGMGAQGTMRTAQQLYEGIDLGGETVGLITYMRTDGVQMAGEAIAAIRGHIGESFGAPYVPEKARIYSTKAKNAQEAHEAIRPTDVSRTPAQMARYLNDEQRRLYELIWKRSVASQMQSAELDQVIVEIADAGGAATLRATGSMIAFDGFLKLYSEGRDDAAPKDEQDDDSRMLPPMRERDALKTGEVAADQHFTQPPPRFSEASLVKKMEEIGIGRPSTYASILTVLRDRNYVRLDARRFVPEDRGRLVTAFLTSFFERYVDTQFTAGLEEQLDDISGGRADWRDVMSAFWQDFSRAVDQTKDLKISDVISALDADLAPHFFPAHLDGSDPRVCTACGTGRLGLKLGRYGAFIGCSNYPTCQFTRRLVVDPKEDGEADTLKDGMRLLGQTPGGEDVTVRRGPWGLYVQQGEPDPEDKKAKPRRATIPRGIEGDKITLDQALGLLSLPRVVGIHPETGEQIEAGLGRFGPYVKMGAVYGSLDKDDDILTVGLNRAVDVLARKLASVRTIAPHPKDGEPVIVRKGRFGPYIQHGTMVVNVPRGEAMEDVTLDQAVALLAEKGKPLKPKGKAAAKKAPARKTAARKAPAKTAAKKAAPDGDADTQARAAKPPARKAAARKTPAGKATGKTAKGKAEPGEGAGPRTRRTATEAG
(46) DNA topoisomerase 1 [Parvibaculum lavamentivorans DS-1]
1
MDVVIVESPAKAKTINKYLGKGFKVLASYGHVRDLPSKDGSVLPDQDFAMAWDVDAKSQKRLNEIATAVKGADRLILATDPDREGEAISWHVLEVLNKKKVLKDVEVQRVVFNAITKKSVTEAMEHPRGLDKELIDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICDRELEIEAFRSQEYWTVEADMKTGGGSPFVARLTVLDGKKLDKFDIPDKKSADDIEARIKASRFSVKSVESKPTRRNPNPPFTTSTIQQEASRKLGFSASRTMQVAQRLYEGVEIDGETTGLITYMRTDGVQIAPEAIAQARTVINNEFGEAYLPDAPRVYTTKAKNAQEAHEAIRPTDLSRLPKHAAKYLDDDQRRLYELVWNRTIASQMESVQLERTTIEIEADDAPIGLRATGSVIVFDGFLRLYQEGRDEPDDGEDGGRLPKVARGDKLGLEKVRPEQHFTEPPPRFTEASIVKRMEELGIGRPSTYASTLQTLRDRDYVHMDKNRLVPQDKGRLVTAFLENFFTRYVEYDFTAELEEKLDKVSAGELDWKDLLREFWKEFTVNVAEALELRITEVLDRLNEVLGPHVFPEKEDGSNPRACPSCGNGILSLKVGRFGAFVGCSNYPDCKFTRQLTVGAEGEEQAGDRVLGTDPETGAEVSLKTGRFGPYVERAPLGDDEKPKRSGLPAKMSAADVDLDTALRLLTLPREIGIHPETGKKITAGLGRFGPFVLHDGTYANLKDPEELFDIGLNRAIAVLAEKVIRAEERAGKVLKELGDHPDTGKPVQVREGKYGPYIKHGTTNATLPKSADPAAVTLEEALALVAEKDAKSGKKKPAAKKAAKKPAAEKKPAAKKAPAKKPEKKKAPAKKKAPAKKPAAKARKTDKASELAD
(47) DNA topoisomerase 1 [Chelativorans sp. BNC1]
1
MDVVVVESPAKAKTINKYLGKDYKVLASFGHVRDLPAKDGSVRPEEDFAMSWEVDSPSAKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLRQKRALKDKPVRRVVFNAITKKAILDAMASPREVDASLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDLEAEIERFVREDYWQIAALLDTPRGDSFEARLTTLDGKRLQKLDIKSQEEADSIKALLDGAAYRVLSVEAKPTRRNPGPPFTTSTLQQAASSRLSFSASRTMQVAQRLYEGVEIGGETTGLITYMRTDGVQMAPEAIEAARSAVSNTFGPRYLPEKPRHYSSKAKNAQEAHEAIRPTDFSRTPDEVRKYLDSDQARLYEMIWKRAIASQMEAAEIERTTVEIEASGAGRAAGLRAVGSVVRFDGFLAAYAEVKDEDSQDEEDRRLPEINSGEALKRNSVNVTKHTTEPPPRYSEASLIKKLEELGIGRPSTYAAILKTLDDRGYVSNERRKLVPQAKGRIVTAFLENFFRRYVEYDFTADLEEKLDEISDGKLSWKQVLRDFWKDFSAAVGDIKELRVTDVLDALNEELAPLVFPTREDGGDPRICPKCGAGKLSLKLGRYGAFVGCSNYPECDYTRQLGENPAENGEAEAGLNGNKVLGTDPFTGEEITLRSGRFGPYVQRGEGKDAKRAGLPKGWTPEDLDHEKAIALLSLPRDVGKHPETGKMISAGIGRYGPFLLHDGTYANLETVEDVFSVGLNRAVSLLAEKQAKTNGARAKPAALKELGEHPDGGVITVRDGRFGPYVNVGKVNATLPKGKDPMSLTREEALELLAAKAGKTGKKPAKSKARS
(51) DNA topoisomerase 1 [Stenotrophomonas maltophilia R551-3]
1
MPKHLLIVESPAKAKTINKYLGKDYTVLASYGHVRDLIPKEGAVDPDNGFAMHYDVIDKNEKHVDAIAKAAKSADDILLATDPDREGEAISWHIAEILKERGLVKDKPMQRVVFTEITPRAIKEAISQPRAIASDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIAAECAHPSQHFNAKLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGALHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVAIGDEGTVGLISYMRTDSVNLSQDALAEIRDVIARDYGIASLPDQPNTYQTKSKNAQEAHEAVRPTSALRTPAQVSRYLTDDERKLYELIWKRAVACQMIPATLNTVSVDLSAGSDHVFRASGTTVVVPGFLAVYEEGKDNKSAEDEDEGRKLPAMKPGDRIPLERIVADQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVEMEGRSFRPSDVGRAVSKFLSSHFTRYVDYDFTAKLEDELDAVSRGEEEWIPLMSRFWEPFKELVEDKKESVDRAEASGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEEKPKFASLRPGQSMHTITLEDALELFLMPRALGEDKGEDVSVGIGRFGPFAKRGSTYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKEFEGSDIQVLNGRFGPYISDGRMNGKIPKDREPASLTLAEVQQLMEETGKPVRKGFGKKAAAKKAPAKKAAVKKEAAPKKAAAKKAPAKKTVKKAAAKKAPAKKAVKKAAK
(52) DNA topoisomerase 1 [Microcystis aeruginosa NIES-843]
1
MSTLVIVESPTKARTISNYLPSGYRVQASMGHIRDLPASAEEIPPAHKDKSWANLGVDVENDFDPLYVVPKTKSKVVKELKEALKGASELILATDEDREGESISWHLLQVLNPKIPTKRMVFHEITKEAIQAALKNCRSIDENLVHAQETRRILDRLYGYTLSPLLWKKISKGLSAGRVQSVAVRLLVQRERERRAFKTANYWDLKATLEKDKNQFESKLVTLNGQKVANGSDFDADTGRLLPGRQVTLLDQATAAALKERIEDKIWRVSHTEEKPTTRKPSPPFTTSTLQQEANRKLGISARDTMRIAQNLYEQGYITYMRTDSVHLSDQAITAARNCVEQMYGKNYLSPQPRQYTTKSKGAQEAHEAIRPAGSSFRLPRETGLSGLEFALYDLIWKRTVASQMADARITQIAVNIQVENAGFRSSGKRIDFPGFFRAYVEGSDDPEAAIDDQEIILPALSVGDTPNCRQLEAISHDTQPPARYSEASLVKTLESEGIGRPSTYATILGTIIDRGYAQMRNKTLIPTFTAFAVVSLLENHFPDLVDPKFTSKMEETLDDIATGSAQWLPYLDRFYRGEKGLESQVKERESQINSSTAKSVILEDLQATIKIGKYGPYLEVSRGDQILTASIPADLTPADLNPEQVETLLRQKTEGPDKLGLHPDSGEPIYLLVGSYGPYVQLGDVSDDNPKPKRASLPKGVKPEDVTLEQAVGLLALPRLLGTHPLTGGKIKASLGRFGPYIVQEQGKEKEYRSLKAGDDVLTITLDRALALLAEPKKTRSARGSTKPPLKELGKHPDDGESVGLYEGPYGVYIKHGKTNAKIPEGETAETLTLEQALVALAAKTTTAKKTTTKKTTSSTTKKTTSPGSKTSKSKTV
(54) DNA topoisomerase 1 [Desulfarculus baarsii DSM 2075]
1
MPKNLLIVESPAKARTIGKYLGPDFIVKASVGHIVDLPPSELGVDLENGFQPHYRVIKGKDKVIKELRAAAAKAGEIFLAPDPDREGEAIAMHIAQQLGRPLESYHRVLFHELTKSAIAKAVAAPAKIDVDRYNSQQARRVLDRLVGYQISPLLWDKVKRGLSAGRVQSVSLRLVVERERAIQAFEPQEYWTVTAMLQGQQPPPFAARLARLAGKKFDPKNEKEAMAGVTAIQGQRFVVEKLTKRQRKQQPAPPFITSTLQQEAYRKLGFAPKYTMGLAQALYEGKQTSEGQMGLITYMRTDSTRLAAEAVATVRALIAARYGQEYLPAKPNAYKSKANAQEAHEAIRPTNAALTPELLEAYLSRDELRLYQLIWNRFVACQMAPAVYDQTQAEIVAGQGLLRASGQVLRFRGFTAVYVEDRDEHGGDEARASAEAKDHDQALPPLPPLDEGQELALQGVEPKQHFTQPPPRFTEASLVRELEEQGIGRPSTYAAILSTIQEKDYVSKDQKRRLIPTELGYLVNDLLVECFPQIMEVGFTAQLEGLLDQVEEGRQDWRGLLADFYGPFQQALGAAKTHMRQIKGKGVETDVKCPLCGKPMAIRLGRNGEFLACSGYPECKSTSDFSRDEKGAIVLQEAAPDPGVACDKCGAAMVVKKGRFGPFLACSAYPQCKNIMALGADGKPVAKPQPEATGEKCPKCGGELVIKPTRSGGRFISCANYPKCNYSKGLSTGVKCPKCGGELVEKRSRRGKPFYGCDNFPTCDYASWDRPIDEPCPQCGHPFLVEKVGKKETVVRCPQPDCNFKK
(61) DNA topoisomerase 1 [Lawsonia intracellularis PHE/MN1-00]
1
MGKNLIIVESPAKVKTIKKFLGSGYVVQSSVGHIRDLPKKNIGVDESKNFSPHYEIIPGKEKIVQGLRETAAKVDTVYLAPDPDREGEAIAWHVAELIKDKNSNIQRIQFNEITSKAVQEALSHPQKLNKNLFDAQQARRILDRLVGYKISPLLWKKVKQGISAGRVQSVALRLIVERDEERYTFIPEEYWLFKANLEGSNPPPFKVELWKVNNKKPIIPDAVTAAALEQQIKDKPFIVDSIEEKERQRSPKPPFITSTLQQAANQRLGYTAKRTMNIAQRLYEGLELGDKGTTALITYMRTDSVRIANEAKLAAATLIEQKFGKEYLAKGGNGRNFKGKAGIQDAHEAIRPIDVTILPEDVKPYLAPDQYQIYRLIWSRFIASQMSVAQFHDTIITINCENSQWRTKGERLLFPGFLAAFPNTKEEEDTNLPVLHKGEILKLHSLIKEQKFTQPPPQFTEASLVRELEELGIGRPSTYASIISTLQDRDYVRLEDKHFIATDLGRVVCMLLQDYFKNLMDVTFTAHMEELLDKVAEGKQDWVELLQNFSETFNPTLEEATKAMSQVKTGLETDINCPDCKKPLVIKFGKSGQFLACSGYPQCKFTSNYLRDDKGQIHLQEKVQPELQKIGICPKCNKDLVLKKARTGSRFIACSGYPECNYTEAFSTNVPCPCEGCKGMLVEKSSKKGKVFYACNTYPTCDYAIWNWPIQKSCPTCSFPILVEKITKAKGKHLACPEKNCRYTCELEESDIET
(65) DNA topoisomerase 1 [Treponema pallidum subsp. pallidum str. Nichols]
1
MEVRGLQPKRQKTFARKHLVIVESPAKAQTIEKYLGTQYVVRASMGHVIDLPKSRLAIDIEHDFQPEYITVRGRAQCLKELRTLSKQSLQVFLASDRDREGEAIAYHLAQSIQAYCDTPIKRIVFNEITPHAIRAAIGHPVPIDTAKVNAQKARRVLDRLVGYHLCPLLWHKVKNGLSAGRVQSVALRLICEREVEVKRFVPEEYWTVEGTFEKDKKSFSALLILIQGKKAVFKSKQEATSAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQCAANRLGFTSRKTMQVAQQLYEGVSLGTHRVGLITYMRTDSVRVSEAAVKEVRAWIATHFSDALPGTPNRYAAKGKSQDAHEAIRPTYVAHTPERIKAHLTRDQIRLYTLIWERFVASQMTDARVRSLTFEITAGPAVFSATETQVIEQGFYRVLKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHFTQGPVRYTDASIVKMLEEKGIGRPSTYAPTISVLLDRYYVTRIQKQLMPTPLGKVISDLLTTYFHDVVDVSFTARMESKLDEVEEDKIKWNCVIADFYPAFSEKVSTVMKDLNSMRGVFDEKTDVVCSQCGDTMVKKLGRFGFFLACGKFPECRNTQPVPLAKCPRPACDGNIVGKKTRGRKEFYGCTRFPVCDFVTHFKPTFAVCPQCRCFLVEKSNRRVGTYTACVNPECRYVSPTRKNLSLGKEAVLDGSHRGAQDKGAVQHYE
(66) DNA topoisomerase 1 [Dehalococcoides mccartyi BAV1]
1
MKEKLVIVESPAKARTISKMLGKDFNIMATMGHIRDLPKSTLGVDVENNFTPKYVSLKAKAKVIKELKEAVKHSKAIYLATDPDREGEAIAWHISEVTKANLSNPKRVVFHEITKEAIDKAFKNTRELDMDLVNAQQARRVLDRLVGYKLSPLLWRKVQRGLSAGRVQSVSLKIIVDREREIEKFVSTEYWNIEALLSKKVKSAAFKATLAGYVTKGKLEIHNESEADQIKKELEVSDYQVLKIKRKSNLRQSPAPFITSTLQQEAWRKLRFSAKQTMVIAQQLYEGLNVEGEGEVGLITYMRTDSTNVARTAVAETRDYITEKYGPAYLPKQARVFSSKVKGAQEAHEAIRPTRINRTPDFIKKSLSADQFKLYQLIWQRMMASQMSPAVFDNTTIDIEAKHQPSKTRYLLRTTSSVNTFPGFTIVYIEGKDEDEEKEQSSLPPMEEGEELKLKSLDATQHFTQPPPRYTEATLIKALEQNGIGRPSTYAPTISTIQEREYITKLKGSLKPSELGMLVNDLLVEHFPDIIGIDFTAAMEAELDKIATEKLDWVPIIRRFYEPFIKEIEAASEKIEKIKPPEEELDELCPECNAKLVIKRGRFGKFIACSRYSKEDDGCRYTRSYQIKTGAKCPDCNSDIVEKYSKKGKIFYGCAGYPNCKFVSFYKPLTKPCPECGALMTKSGQNWAKCTKCGKRKKLEDES
(68) DNA topoisomerase 1 [Rhodospirillum rubrum F11]
1
MHVVVVESPAKAKTINKYLGKDYVVLASYGHIRDLPPKDGSVRPDEGFAMDWEIDAKSEKHVKDITQALKSADGLLLATDPDREGEAISWHVRDVLEKRKALVGKQVQRITFNAITRSAVEEALRNPRDLDTPLVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREQEVERFVSREYWTVDAILASPQGQIFRARLSQLDGQKLDKFGLPDETTALAALERIKAATLRVESVERKQARRNPAAPFTTSTIQQEASRKLYFSARQTMQVAQKLYEGVDLGGETVGLITYMRTDGVSIAPEAVFATRDLIGAEFGAAYLPEQPRVYKTKAKNAQEAHEAIRPTDVARTPQSVAPYLTAEQRKLYELVWKRTVASQMASAILDQVAVDIADPEAKVVLHATGSVIQFDGFLKVYREDFDDRPESSPDGAGEDENRLLPPLREGDGVKREDVKADQHFTQPPPRYTEASLVKRMEELGIGRPSTYASILSVLQDREYVRLDARRFIPEDRGRLVTAFLENFFSRYVQYSFTADLENQLDEISDGKLGWKTVLERFWMDFKAAIEGTATLRVSEVLDALDKELGPHLFPQAEDGHDPRVCPVCSAGRLGLRIGKFGAFVGCSNYPDCKFTRPLVTKEGEGGDGAALAEDGTKPLGKDPVSGEDVTLRKGPYGLYVQKGEAAPVEKGKKAVKPPRVSIPKDMDAATIDLDIALKLLSLPRPVGDHPETGTMISAGIGRFGPYIKHGDIYKSLPKDDDVLTIGLNRAVSLLAEAGKGGRARQPARSLGDHPADTKPVTIHDGRFGPYVQHGGVRATIPRTADPATYTLAEAVELIAAKAAKDGDGKKAPAKKAATKAPVKKAAAEKKAPAKTATKKAAPKKAADSAEDAPAKAPRKSKAKPASADPD
(70) DNA topoisomerase 1 [Methylobacterium nodulans ORS 2060]
1
MKVVVVESPAKAKTINKYLGHGYEVLASFGHVRDLPAKDGSVDPEQDFKMLWELEDRGAKRVSEIARAVKGADKLILATDPDREGEAISWHVLEALQAKRVLKDVSVERVTFNAITKDAVQTAMAQPRQIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIEAFRPREFWSLVATLATARGAVFDARLVGADGKRIQRLDIGTAEEAEAFRRDLELATFTVGNVEAKPARRHPQPPFTTSTLQQEASRKLGLAPAQTMRIAQRLYEGVEIGGETVGLITYMRTDGVDMAPEAIQDARRVIGAEFGDAYVPAAPRSYSVKAKNAQEAHEAVRPTDLGRLPKEVARFLEPEQARLYELIWIRTVASQMESAELERTTVDIAAQVGPRRLDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPSMAAGEALRRERIAATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQVLRDREYVRLDKKRLVPEDKGRLVTGFLESFFRRYVEYDFTADLEEQLDRISNAEIDWRAVLRDFWRDFSAAIAGTKELRTAEVLEALNQLLGPHIFPPRADGANPRACPNCASGTLSLKLGKFGAFVGCSNYPECKYTRQLSAAGVEGEGDGSSGEGGQPGQRVLGEDPATGLPVTLREGRFGPFVQLGEASAEKGAEKPKRSSLPRGLSPAEVSLETALKLLALPREVARHPETGEPILVNLGRFGPYVQHGKTYANLGKGDDLLEIGANRAIDLIVAKEQGGGRPAADPGRVLGNDPESGRAVTVKAGRYGPYVTDGEVNATLPKGADRDAITLDEALRLIAARREAGGGTKKKATTRTRKSETAAKPAGKATKKAPTKASAAKKKAAAE
(74) DNA topoisomerase 1 [Geobacillus thermodenitrificans NG80-2]
1
MSDYLVIVESPTKAKTIERYLGKKYTVKASMGHVRDLPKSQMGVDINDGYTPKYITIRGKGQVIKELKTAAKKAKKVFLAADPDREGEAIAWHLANMLDLDIHSDCRVVFHEITKDAIKQSFQQPRSINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIRQFQPEEYWTIQAKFQKGKEAFAASFYGVDGEKLELKTEADVKEVLARLNGRAFTVKTVTKRERRRSPVPPFTTSSLQQEAARKLNFRTKKTMMVAQQLYEGIDLGGEGTVGLITYMRTDSTRIAETAQQEAAAYIEATFGAQYVHQEKRKEKKSTNAQDAHEAIRPTSAFRDPDKVKPYLTRDQFRLYKLIWERFIASQMAAAVLDTMSVELENNGVLFRASGSKVKFPGFMKVYIEGTDDQTEEQDRLLPDLEEGEAVESEMIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVVELILEFFPEIIDVEFTAKMEKELDEIEEGKVEWIKVVDEFYREFEKRLKVAEKEMREVEIKDEPAGIDCDVCGSPMVYKMGRFGKFIACSNFPECRHTKPIVKEIGVKCPKCHEGNIVERNSKRKRVFYGCDRFPECDFVSWDKPLARPCPKCGGLLVEKKLKKGVQVQCTACDYEEQPEA
(77) DNA topoisomerase 1 [Aerococcus urinae ACS-120-V-Col10a]
1
MATKRKKTPKKDLVIVESPTKAKTIEKYLGRKYKVVASKGHLRDLPKSKMGIDIENNYDPHYITIRGKGDTIKDLKKEAKKANNIYLASDPDREGEAIAWHLAHILKLDPKEDIRVTYNEITKDTVKEAINNPRAIDKDLVDAQQARRILDRLVGYNLSPILWAKVKKGLSAGRVQSVALKMVVDREDEIRNFVPEEYWSIEGVFQKGKETFKANASKYKGKKIDLKNEDDVKALMANLSSDQFEVQNLTKKQRKRNPQKPFTTSSLQQEASKRLRFRTRKTMMVAQQLYEGIKLGSEGTVGLITYMRTDSTRISEGAKQEAGQFIQEKYGKEYIGKGTSGASGQGAQDAHEAIRPTSAFRHPDSVEAYLSKDQFKLYSLIWSRFMASEMAPAVYDTVACDLVQNDVSFRANGSKIKFTGYLRVYPDNNEKDNLLPELENGEKVKSKELTPNQHFTQPPARYTEASLIKTLEELGVGRPSTYSPTLETLIKRYYVKLEARRFEPTELGEIVNSLISEFFPDIVDPQFTANLEDELDHVEDGNKNWIDVVDAFYQPFSKDIEKADQEMEKIEIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVNCPTCKEGQVVERKSKKKRIFYGCSRYPDCDFVSWDKPVGRSCPKCDHYLVEKKKRGSKQVICSNCDYKEDVQKGDD
(80) DNA topoisomerase 1 [Chlorobium limicola DSM 245]
1
MASKTEALSARNRTLIVVESPSKAKTINKYLGDRYTVFASVGHIKDLPKREIGLDFDHNYEPRYEVIAGKEKVVRQLKKLAGEADSVLIATDPDREGEAIAWHISNEIEAARKPVFRVLFNEITKNAILAAISEPRQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVLRGLSAGRVQSVALRLICEREEEINRFEIQEYWTVSADFATAKGEIFKAKLVKVDGGKPELSSQEQAEAAASLVRNRLYAVGDITAKAQQRKAPLPFTTSLLQQAASNQLGFGSQKTMRIAQQLYEGIDLGSEGATGLITYMRTDSTRIGSEAVAEAHKYIRAVFGSEYTGYGSSAKSPKNAQDAHEAIRPTSIERKPEAMKPYLSADQYRLYELIWKRFLAAMMAPAKIEQTKVDVEDHERRIVFRANGSRVLFPGFMRVYDDQQELEYEARTSTKEDVEKEQTVKLPDTLAARDSLNLDEIEQKQSFTRPPARYSEATLVKDLDNYGIGRPSTYASIFSTLQDRRYVVLQKKKIAPTDLGKDVSQILVANFPDIFNIRFTAFMEDELDKVAAGDDEYEKVLDSFYRPLETALSLRKNDPLIPQNMNAETCDKCGEGRMIIKWTASGKFLGCSRYPACKNIKPISSTKAKPKETGIKCPSCSDGQMLLRDGRLGPFLACSGYPKCNTLLNLSKQRHIEPLKTPPVQTDLPCPKCGAPLYLRSGKRGLWLGCSKFPKCRGRLAWNSLDPALQLHWEGVMAEHRKAHPDVVLTMTDGRPVPMTLPVDDIMARAEENGLIAPVTEENEGVTV
(82) DNA topoisomerase 1 [Kyrpidia tusciae DSM 2912]
1
MADYLVIVESPAKAKTIGKYLGKGYMVKASMGHIRDLPKSKLGVDIAHDFEPHYITIRGKGDVLKTLRDASKKVKRVYLAADPDREGEAIAWHLANYLDVNPDGPCRVVFHEITKQAVQEAFAHPRPIDRDLVNAQQARRILDRLVGYKISPLLWKKVRKGLSAGRVQSVALRLVCDREKEIREFKPEEYWTLTARFKVDGRTFEAKFVGVGDQKVELANEEEVKAILARISGQSFTVIGVRKSERRRNPAPPFTTSSLQQEAARKLNFRAQKTMSVAQQLYEGLEIGKEGSVGLITYMRTDSTRVSPVAQEQARSYVEKTYGAAFLPEKVKQYQTRSGAQDAHEAVRPTEVARTPESIKAYLNRDQYRLYKLIWERFVASQMAPAVLDTVSADIQAGDVLFRAAGSKVKFPGFMTLYVEGEDDAKDEENRDLPDLRQGQELPEPALEPKQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLETIQKRGYVLLQERRFVPTELGEVVVELLKEFFPEIIDVEFTAQMEERLDGVGEGRVNWVEMLEEFYQDFQKQLDLAEQAMQHVHLEEEESDEICEKCGRRMVYKHGRFGKFLACPGFPECRNTKPILKSIGVPCPKCGGDLVERRAKRGRIFYGCKNYPSCDFVLWDRPTGEKCPRCGSLLVLRKAKDKETVQCSNPQCDFKGNALEKAEKGNSAGRRSAVETM
(83) DNA topoisomerase 1 [Rickettsia africae ESF-5]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESIDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPATMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMDQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(86) DNA topoisomerase 1 [Brucella ovis ATCC 25840]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKTVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAITKSFSAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFAGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(89) DNA topoisomerase 1 [Clostridium saccharolyticum WM1]
1
MANCLVIVESPAKVKTIKKFLGANYEVDASNGHVRDLPKSQMGIDVENDFDPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLMKALKLDELKDKQVYRISFNEITKNAVKASLKTPRVIDMDLVDAQQARRVLDRMVGYMISPLLWAKVKRGLSAGRVQSVALRLICDREEEIGAFIPEEYWNLEAVLKQEGSKKPLIAKFYGDKDGKIPIRNKEELEKILAGLEKQTYQVEEIKNGERIKKAPIPFTTSTLQQEASKVLNFSTQKTMRLAQQLYEGVEVAGRGTVGLITYLRTDSTRIAEEADAAAREYIGKQYGGQYVANGEQQKKSNAKIQDAHEAIRPTDISLTPVMVKESLQRDLFRLYQLIWKRFTASRMQPAVYETTSVRVGAGKYLFTLSASRLSFDGFMSVYVQEDDKEEANVLLGNLEKGSFLKLDKLESGQHFTQPPAHFTEASLVKAMEEQGIGRPSTYAPTITTIIARRYVAKENKNLYVTELGEVVNRMMKKSFPSIVDITFTANLEYLLDKVGDGSVQWKTVVKNFYPDLKEAVDKALVELETVTIADEVTDEICEVCGRNMVIKYGPHGKFLACPGFPECKNTKPYLEKIGVPCPKCGKEVVIKKTKKGRIYYGCEANPECDFMSWQKPSTKTCPKCGAYMVEKGSKLLCSNEQCGYSTDK
(90) DNA topoisomerase 1 [Thermotoga maritima MSB8]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGVDLEKDFEPEFAVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGRKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITVNFDGLTAEIDVKEKKFFDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPEEAGKYLNSDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFPFEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFDRNDRIVVDFPTNQKCSCGKEMRLSFGKYGFYLKCECGKTRSVKNDEIAVIDDGKIFLGRKDSESGSPDGRSVEGKGNLSEKRRKGKKGS
(91) DNA topoisomerase 1 [Thermotoga maritima MSB8]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGVDLEKDFEPEFAVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGRKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITVNFDGLTAEIDVKEKKFFDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPEEAGKYLNSDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFPFEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFDRNDRIVVDFPTNQKCSCGKEMRLSFGKYGFYLKCECGKTRSVKNDEIAVIDDGKIFLGRKDSESGSPDGRSVEGKGNLSEKRRKGKKGS
(95) DNA topoisomerase 1 [Desulfobacca acetoxidans DSM 11109]
1
MTKSLLIVESPAKARTLQKYLGKDFEVRASVGHIKDLPKKELGVDVEKNFIPKYVTIDGKTKTIQDLKRAAHDVEDIYLGPDPDREGEAIAWHIAEVLKSGKHRFHRVLFYELTPRAIQEALAKPMELNRPRYEAQQARRILDRLVGYQISPLLWEKVKRGLSAGRVQSVALRLICDREREILAFVSQEYWSLTAHLKAEQPPPFQAKLIRYKGKKLELAKAEQTQAVVAALEGAQYTVTAVEQKERQKKPLPPFITSTMQQEASRKLRFAAKKTMQVAQRLYEGKDLGAAGPVGLITYMRTDSTRVAGEAVAAVRDFIRQEFGPDYLPAKPNAYKSRKTAQEAHEAIRPTDVSRTPAAVAPFLEKDELRLYELIWKRFVASQMEPARLLVTTADISANHYTFRATGTVVKFPGFTVLYEETPDAAGEEEDIKLPPLKVGELLELLQLEPKQHFTQPPPRYTEATLIKELEKQGIGRPSTYATILSVILGRLYVAKIKAGFKPTELGLMINDLLVASFPKIMNVGFTANLEDRLDAVAEGEVIWQEVLRDFYGSFSQELQEAKQVMPRVKSLATGLTCPQCGAELLIKWGKTGEFLGCSGYPECRYTRNFSRDEQGRIVPEEKNNVPAPDLPEITEVCPKCGQTLVAKQGRFGPFLACPGYPKCRYTRSLQEEEGEVEAVPCPQPDCTGVLRARKSKRGVFYGCSNYPECTYALNYPPVAKACPQCGFPVMVRKELKKQGKILACPQKSCGYTEPDLDEPGTD
(97) DNA topoisomerase 1 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
1
MAGTTLLIVESAAKARTLGKFLGKGYKIKASVGHVRDLPKSKLGVDVENDFEPQYITIRGKGDILKEIKDESQKAGRVLLATDPDREGEAIAWHLQNAMKIPPEENCRIEFHEITREAVKKAIKNSRPVDLSRVNAQQARRVLDRLVGYNLSPLLWNKIRKGLSAGRVQSVALKLICDREEEIKNFIPQEYWTVDAIFNAAKGKNSKFTARLASYQGKKIEINSDKEVAAIGEYLQGANFTVLKVERKEKRKNPNPPFITSTLQQEASRRLNFFSNRTMRVAQELYEGLEIGKEGTVGLITYLRTDSTRVASSAQMEALDFINSTFGAEFAPDKPNEYKSRKSAQDAHEAIRPTSIQRTPESVKAFLSRDQYRLYQLIWNRFVSSQMTPAVYDSLTVDISAGDYGFRASSSQLKFIGYKKVYSDNEEEEPKNNIPELKKGEELALHELKPEQHFTQPPPRFSEASLIKLLEEKSVGRPSTYAPTIDTILKRNYVERQNRQFIPTELGFIVVDLLKEHFANILDVEFTARMEGELDLVEEGKLDWKKVVRDFYEPFHSDLEKARELAQKIEIKDEEAGKECPQCGRPMLIKHGRFGKFMACSGFPECRHTQSINQELGLKCPLCQGSIVALKSKKGRTFYGCSNYPQCNFRSWDKPTGKICPHCGDAIVEKFNKKKEATQICQNPACKQKVEMGG
(98) DNA topoisomerase 1 [Chlorobium tepidum TLS]
1
MASKSATPSARNRTLIVVESPSKAKTINKYLGDDYTVYASVGHIKDLPKKEIGIDFDNHYEPRYEVIAGKEKVVRQLKKLAGEADKVLIATDPDREGEAIAWHISNEIDFAKKPVFRVLFNEITRNAIIEAIGHPQQIDYRLVRSQQTRQALDKIVGYKISPFLWNVVYRGLSAGRVQSVVLRLICERETEIEAFTPQEYWTIYADFTTENGETFRTKLVKVNGEKPDITSGEQAEAIASAIQGRLFAISEIVPKVIQRKQPLPFTTSLLQQAASNQLGFGSQKTMRTAQQLYEGIDLGSEGATGLITYMRTDSTRISGEAVAQAHDYISQQFGPEYKGFGGQGKAGKNAQDAHEAIRPTSVTRTPESLRRHLTPDQFRLYELIWKRFVASMMAPAKIEQTRVDVDDQKKEFVFRATGNKVLFPGFFRVYDDQQELDYEAQKSTREELEKEQIVKLPERLSVDEQLKLAELDRRQSFTRPPARYTEASLVKELDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTELGRDVSAILVANFPDLFNVRFTAEMEDELDKVASGDDEYEKVLDRFYRPLESVLSHRKSDPLIPQNRDAVLCEKCGKGHMIVKWTTSGKFLGCSNYPKCKNIKAITTNKAKPKETGVRCPVCGEGHMLLRNGRLGPFLACSNYPKCNTLLNLSKQRHIEPIKTPPITTDLACPKCGAPMYLRTGKRGLWLGCSKFPKCRGRLSWSTLDPETQARWEKAMNEHMAAHPSLAITMLDGKPAPMNLPIEDIIARAEDAGLISATSEQPEAEATT
(102) DNA topoisomerase 1 [Bacillus megaterium WSH-002]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLAADPDREGEAIAWHLAHSLDVDIASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKVELSNENDVTNIVKQLDGNEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISETAQTEARDYITNAYGNQFVATEKRKEKKNSNAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEFYSDFEKRLEHAEKEMREVEIKDEPAGEDCEECGSPMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPKCEEGNIVERKSKKKRTFYGCDRFPGCDFVSWDKPIARKCPKCENLLVEKKQKKGTQVVCTSCDYKEEAQQ
(104) DNA topoisomerase 1 [Odoribacter splanchnicus DSM 220712]
1
MIENLVIVESPAKAKTIEKFLGNGYTVKSSFGHIRDLEKKDLGVDIEHNFQPKYEISSDKKTIVKELKTLAKEAKTVWLASDEDREGEAIAWHLFEVLKLKPENTKRIVFHEITKDAILHAIQNPRNIDKNLVDAQQARRVLDRLVGFEMSPVLWKKVKPSLSAGRVQSVAVKLIVEREREINAFKEQQYYRVCGTFETQQHAQLKAEVQTRFTDKETTLTYLEACKTAIFHVDSVETKPTTRKPAPPFTTSTLQQEASRKLGFSVSQTMSVAQKLYEHGLITYMRTDSVNLSDLAIRTAKAVICETLGEKYSKPRNFATKTKGAQEAHEAIRPTYMNKTAIEGDRNEQQLYELIYKRTLASQMADAQLERTNMIIGLSNHSIPFTATGEVIIFDGFLKVYMESHDEETDDEQAGLLPALAPGDQLQRQLITAIEQYTLHPPRYTEASLVKKMEALGIGRPSTYAPTITTIQNRGYIIKESREGVERNIEQIELKGNDIKIKTNKKIFGAEKKKLFPSDMGMVVTDFLSEHFTNIMDYNFTAEAEEALDDIAEGSVEWQKMIGEFYHPFHETVESTLKNSERNSGQRILGTDPVSGETVSVRIGRFGPMAQIGEGEHVRYAGLLKGQLMETITLEEALGLFKFPRKIGQYEDKDVSIGIGRFGPYIKHNNVFVSLKKGEDDPGTITLETAIQRIEEKRESDRNKLIKAFDNGVQILNGRFGPYISYNKANYKIPKTCKADELTLEKCMELIEKEGSKKKPGGSSKKTPVRKAQTTTKKKN
(105) DNA topoisomerase 1 [Francisella philomiragia subsp. philomiragia ATCC 25017]
1
MAKNLVIVESPAKTKTIKKYLGNDFDILASFGHVREIPSKDTSIDVNDNFKIKFTTSERSKKHLDAIKKAAKSAENIYLATDPDREGEAISWHVQEVLKNAHLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVNAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLIEFNNTKVEQFTFIAEKDAKKAKSTIVKDANGFLIVEGVTEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIESKFDKDMLPSKPRVFDKKSQNAQEAHEAIRVTAANRTPESIKQHLTSDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHKFRVTGTVIVDAGFLKIYNVEKDEDEKDSDDEQTLPEFEKGEKVPLKDIITKAHSTEPPPRYTEASLVKALEKHGIGRPSTYATIISTLQQRDYVEVEKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIANHKNDYLSVLNSFWHPFIEKINKISEDVSRKDVVTEELDEDCPECGSKLSSRLGKNGRFIGCTNYPTCKYTRRVDSDGKEVEKEEPTVVEDRKCPECGSDLHIKQGRYGKFIGCSNYPTCKHMEPLEKPKDTGVVCPKCNKNNIVEKKSRKGKVFYACSGFPKCKNAYWYPPIKEDCPKCKSPILLHKTTKKDGEQKACPNPECDYAVPWEENN
(109) DNA topoisomerase 1 [Listeria monocytogenes M7]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLELDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVNGKKKKLSTADDVKEVMSAIKGKSFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEASNYIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSAMRSPQEVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVKTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFIPTELGEIVNEMIEDYFPEILDVKFTANMESELDEVEHGEVEWVKVIDEFYKRFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVYKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERACPKCEKRALVEKKLKKGVQVQCTNCDYKESTQQ
(119) DNA topoisomerase 1 [Heliobacterium modesticaldum Ice1]
1
MSNKVLVIVESPAKAKTIGKFLGRRYQVKASMGHVRDLPKSQFGVDVDGGFNPKYITIRGKGELLKELRTAAKKSDQILLGPDPDREGEAIAWHLAQVLGVDEHTPCRIEFNEITKSAIQKAVKKPRPIDTNRVEAQQARRILDRLVGYNLSPLLWRKIRKGLSAGRVQSVAVRLISDREEEINDFTPDEYWSLTAELKAVKGNLQARLVRQDENKLEIKSREEMDRILGELAGQVFAVSEVKRKEKRRNPSPPFTTSSLQQEAYRKLGFTARKTMMIAQQLYEGLDLGKEGTVGLVTYIRTDSVRVSDGAVEEVRQHIQTRFGSDYLPAEPRVYENKGKIQNAHEAIRPTSVTREPETLKAVVTNDQYKLYKLIYERFISSQMSSAIMDTTTIEIKAGAFGFRASGAVLKFPGFMKVYIEGRDDDSKEEEGLLPEVSVDEKLDLQKLEPKQHFTQPPPRYSEATLVRALEERGIGRPSTYAPIIETIVARGYVVREDKQFYLTELGEVVVDLLKEHFPDIIDVEFTADMEAKLDAIEEGAADWRRILRDFYEPFRETLEEAEEKIGEIEIADEVTDQRCEVCGANLVIKQGRFGRFLACPRFPECRFTKPLLEEIGVPCPKCDGHVVIRRTKKGRKFFGCANYPECDYVSWERPTNVPCPLCDKPLVQKESKKLGTRRVCITEGCGYEEAVSDGEKGASTGWPVGDPRAQGGPGERRELAEPGVP
(121) DNA topoisomerase 1 [Maricaulis maris MCS10]
1
MNVVVVESPAKAKTINKYLGADYTVLASFGHVRDLPAKDGSVKPDEDFEMAWEIDTASAKRVKAIADAVRESDRLILATDPDREGEAISWHLLEALQKRRVLKDVTVQRVAFNAITKPAILEAMAHPRAVDMELVNAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICDRELEIEKFRSEEYWTVDADLTANSDSFRAKLVTLGGKKLQKLSIKDRASANAAVEAVNSANLSITGVEAKPAKRNPPPPFTTSTLQQEAARKLGFSATRTMQTAQKLYEGVTLGGETTGLITYMRTDGVTMVPEAVSQARDVIGKEHGSLYVPSAPRHYASKAKNAQEAHEAIRPTSFSRLPEKLSLDADMARLYQLIWRRAVASQMESARFERTTVDIASPDGQTALRAVGTVQLFDGFLALYQEGRDDEEDEGENRLPKLTQGAAATVAKTHADQHFTQPPPRFTEASLVKRMEELGIGRPSTYASTLQVLRDREYVQMEKNRFHPFDKGRVVIAFLENFFARYVEYDFTASLETQLDKVSAGELDWKQLLRDFWTDFRAAIDEIGELRITNVLDALNEALAPHIFPEKEDGTDPRLCPSCKEGTLSLRLGKFGAFLGCSNHPDCSFTRQMSPPGEDDAQGDRVIVQHPETGKDVELKNGRFGWYLQMQLDGEDKPKRSSIPKGWDAATLTEEQAIKLIDLPRTVGEHPDDGQPITANIGRYGPYVHHDKTYANIPSVEEVFEIGLNRAVSVIADKRANGGRRGATASALKELGEHDGKPVRIMSGRYGPYVKYEKINATLPKDTDPESVTLEQAMEWVEAKAAKGGKKKAPAKKKAPAKKKAPAKKATAKKPAAKKTAAAKDKAE
(122) DNA topoisomerase 1 [Clostridium novyi NT]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVTASMGHVRDLPKSQLGVDIENNYNPKYITIRGKGELLSSLRKQAKKSDKVFLATDPDREGEAISWHLAEALKIDENEECRIEFNEITKNAIKSAIKNPRRLNLNLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMICDRENEIKEFNPKEYWTIECELKNEKSKKSFTVKLVSKNNEKIEINNEEESNSIIKELKQNKYIVKSIKKSEKHKKPLPPFTTSTFQQDSYKKLNFSTKKSMSVAQQLYEGIDIKGKGTIGLITYMRTDSVRISDEAQKNARQFITENFGQNYVPESIRNFKGKKNIQDAHEAIRPTYIELAPDEIKDNLKPDQFKIYNLIWKRFMASQMADCIMDTMSININNGQYTLRVSGSNIKFDGFKKVYKYEEDEESLKFPVLEENEILQDKKVEGKQHFTQPPARFSEATLVKTLEENGIGRPSTYAPIVSTLLDRKYIEREKKTLTPTELGFIVNNIVSEYFKQIVDVEFTAEMESKLDNIEEGKEKWKDVVNEFYSPLIECINIAEKEIAKIKIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVKELDVPCPVCGGKILLRKSRKGRKFYGCSNYPECNFVSWSEPVKDKCPNCGSYMVKKQSKSKGNYIECSNKECKTKIQQENQNVEK
(123) DNA topoisomerase 1 [Campylobacter concisus 13826]
1
MKSLIIVESPAKAKTIKNFLDKSYNVIASKGHIRDLPKTSFGIKIEDDKFTPEYRISSDHSAIVKEIKELAKGADEIYLATDEDREGEAIAFHIANAIGKEPTSLPRIVFHEITKSAIQNALKSPRHVDMNSVNAQQTRRLLDRIVGYKLSPLLNLKIQKGLSAGRVQSAALKIIVDREREIQAFKPVEYYTIDTVFKKDLDAELVKFENQKIEKLTIQNPDRAKYIIENLQNEKFSVREIESKDRKIQPSPPFMTSTLQQSASNRLGFSPKKTMMIAQSLYEGVQTNEGFMGAITYMRTDSLNLAKEAVAAAREHILQNYGKEYLPAKAISYTTSSKGAQEAHEAIRPTNLNFTPQIAAKFLEKDALKLYTLIYNRFLACQMSACVSQTQNVYVASEKGEFKISGRKVLFDGFYKVYGELDKDKILPNLKKGDEMSLQSIKSTQNFTEPPARYSEAGLVKKLESLGIGRPSTYAPTISLLTSRDYVRIEKKQLIPNEIAFSMIGVLEEHFSNIVDSEFTSHLEEKLDEIALDKADWQKVLSDFYYPFMEKISAGKTGIKSLKTATPIGEKCPECGSELVLRKGRYGEFIACSNFPKCKYSRNVAKDNEKSAETGSTTAAKPKRELKKLDVPCPKCGGEIVERFSRRGKFYGCANYPKCDFISNYEPVAQKCDECGGDMIKKELKKGTFIECTKCKKKTLVSEN
(128) DNA topoisomerase 1 [Brachyspira hyodysenteriae WA1]
1
MATTTEEKVKKTASKKTKDKKESKKKKLVIVESPAKAKTINRYLGSDYLVMSSMGHLIDLPRSRLAIDVDHGFEPEYITIRGRAKILNELKKEAKKAEEVLLAADDDREGESIAWHIGNKIRGVNSAVPIKRIVFHEITKDALKEAIDQPRDIDISKVNAQKARRVLDRLIGYNLSPLLWDKIKRGLSAGRVQNVALLIICNREDEIETFVPVEYWTFGVFLKHKNKEFLAELQKYKGEKPDLKTKQDVEDIMEHLKDKTYTVASIEVKDRLRNPTAPYTTSKLQQAASSALGYSASKTMQVAQSLYEGVDIAGEATGLITYMRTDSVRISPVAQEQAKEFIEKEYGSNYLPPEPPTYSVKKNAQDAHEAIRPTNIFLTPDSIKEYLKTDQYKLYKLIWERFVSSQMLPAKMKNTRAIIVAGDCEFSLSSSKIEFDGFMKVLTIDKEDKEKASKMPNLSKDDVCEFVENNPQQHFTTPPPRYTDASLVKILEESGIGRPSTYAPTIKTIISRHYVQRKGKQLVPTELGKLVNELISENFPELVNINFTADMESKLDKIEDDNIEWNNILKEFYPHFLDTLKTATENINNMKDFFNEETDFVCEKCGKKMIKRLGRYGYFIACSGFPECKNTKGISFGVCPKCGGDITLKRSKRGREFYGCSNYPKCDFVSWDKPLQEPCPKCGGLMVEKNIKNKGLFKVCIKEDCGYSEEIKEDEE
(129) DNA topoisomerase 1 [Caldicellulosiruptor lactoaceticus 6A]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEVLKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVSCPKCSKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGGLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(132) DNA topoisomerase 1 [Thermosediminibacter oceani DSM 16646]
1
MAKSLIIVESPAKAKTISRFLGKEYRVAASMGHVRDLPKSKLGIDIEKGFVPKYITIRGKGSIIENLRKEAAKAQKVLLATDPDREGEAISWHLAHLLDIPPETPCRVEFHEITKTAVSESLRHPRKINMNLVDAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSAAVRMICDREKEIAEFVPEEYWTIEAELADRPDGSSFKAKLHSRGNEKINLKNREQVEKIVADLQDQVFVVMEIKRGERRRNPAPPFTTSTMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGTVGLVTYIRTDSTRISEQAQKEAKEYIKANYGSEYVAESMSVKKAKKNIQDAHEGIRPTSVFRHPDSIKDSLTLDQYKLYKLIWERFLASQMAPAVYDTVSIDIKAGSYIFKASGSTLKFTGFMAVYIEGADEETEKDEGTLPILEQGQKLTLLKIMPEQHFTQPPPRFTEAMLVKALEEKGIGRPSTYAPIIDTIQKRGYVKKEKGRFKPTELGQLVTEILKEYFSDIVDLDFTAEMENQLDKIEAGEENWQKIIESFYRPFEEKLKIAEEKIEEVKIEDEVTEEKCELCGRNMVIKHGRYGKFMACSGFPECKNTKPLLEETGVKCPVCEGVIVVRKSKKGRKFYGCSNYPNCEFVTWDPPSETPCPRCGGLMVVKSTKSGKITACTNTECGYKDQVEG
(134) DNA topoisomerase 1 [Streptococcus uberis 0140J]
1
MVTKTKSVAKTAKKKATKKKSTSPQKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPEYINIRGKGPLINSLKKEAKNAKKVFLASDPDREGEAISWHLSHILGLESDDKNRVVFNEITKDAVKNAFLEPRVIDMDLVDAQQARRVLDRIVGYSISPILWQKVKKGLSAGRVQSVALKLIIDRENEIKAFVPEEYWTIDGLFKKGRQKFQASFYGLNGKKMKLETNDDVKFVLSHLKSDAFDVTTVEKKERRRNAPMPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGINLGSNGTQGLITYMRTDSTRISPIAQNEAAAFITERFGSNYSKHGNKVKNTNGAQDAHEAIRPSNVHYTPESIAKYLNKDQLKLYTLIWNRFVASQMTAAIFDTVKVTLEQNSVSFIANGSQIKFNGYMAVYNDSDKNKMLPEMTQGEVVTKESTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVNVTFTAEMEAKLDQVETGERQWQTVIDTFYKPFAKDLEKAEDEIEKIQIKDEPAGFDCDLCGHPMVIKLGRFGKFYACSNFPDCRNTKAITKEIGVTCPICKKGQVIERKTKKNRVFYGCDRYPECEFTSWDIPVGRECPKSGDYLVEKKIRGGGKQVVCSSESCDYKEEKIK
(136) DNA topoisomerase 1 [Thermoanaerobacter brockii subsp. finnii Ako-1]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKGYANPEANYVSKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVEEFYKDFYKTLKIAEEQMEEIEVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPDCDFILWDKPVEEKCPVCGSMLIEKNTKNVHILKCSNPGCDYQKEVK
(137) DNA topoisomerase 1 [Prevotella denticola F0289]
1
MQENLVIVESPAKAKTIEKFLGKDYKVMSSYGHIRDLKKKELSIDLDTLTPDYEIPDEKKKVVSELKKNAKAAKKVWLASDEDREGEAISWHLCEVLGLDEEKTSRIVFHEITKPAILKAIETPRHLDMNLVNAQQARRVLDRLVGFRLSPVLWRKVKPALSAGRVQSVAVRLIVEREREIQNFASEPYYRLNAVFAVTNEDGSKNEVKAELNKRFKTHEEALAFLELCKNARFRVASIARKPLKRTPAPPFTTSTLQQEAARKLGFTVSQTMMVAQRLYEAGRITYMRTDSVNLSALAINTSKAEIERLYGAEYGKVRMYHTHSKGAQEAHEAIRPTYIDNVSIDGTSQEKRLYDLIWKRTIASQMADAQIEKTTVNISLETEDGKNQTDLQFVANGEVIAFEGFLKVYHESSDDEEGGEEFSHALPAMHEGEELERREIVSTERYSQGPGRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVQKGDRKGEERKYVVDTLLGLKVTSRTKKEMAGADKGKLIPTDIGIVVNDFLMENFPDIMDYNFTAKVEQEFDKIAEGKVAWNKEMKTFYQGFEPEVEKVMNARSEHKAGERELGIDPKSGKPVFVKIGRFGPVVQIGSADDEDKPRFSQLPAEKSIETITLDEALELFRLPRTVGQFEGTDVVIGAGRFGPYVLHNKKYTSLPKDEDPLTISLDAAINLIQKKRLQDAQRHLKTFEEDSRMEVMNGRYGPYIAYDGKNYRMPKALHEKAAELTYEQCMDIVKNAPEPRRRKQ
(138) DNA topoisomerase 1 [Sphingobium japonicum UT26S]
1
MQLVIVESPAKAKTIEKYLGGDFHVLASYGHIRDLPPKDGSVDPDNGFAMSWENYGDKGKQLKAIADEAKKATRLILATDPDREGEAISWHVQEVLRAKKALPQKVDRVTFNAITKQAVTEAMAQPRALDEDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIESFVPQEYWSVAAEMEQAGQGFTARLVKWRGEKIERLTIGREGDAMAAKADVEAGRFTVEKVETKPVSRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQQLYEDGAITYMRTDGVQMDGSAISAARKAIAERYDGGYLPEKPRQYQTKAKNAQEAHEAIRPTEFYRDKVGSGDHARLYDLIFKRALASQMASARLERTTVDLVDGTGQHGLRATGQVVIFPGFLALYEEGRDDPERGSGKHASADGEDDDSKLLPRMAAGDAPAKRKVTAEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASTLQVLKDRDYVRIEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEEELDDISGGRAQWQAVLEAFWRDFKPKTAEVMEQKPSDITAELDKFLEPMLFPPKADGSNPRACPMCGDGQLSLRGGRFGAFIACSNYPECKYTRKFGQPGGDKDGEDTGPEVLGQHPETGQDIVRKSGRFGPYIEMGEGKEAKRGSIPKDLPDGELTLDWAVKLLSLPREIGPHPETGKPIVANIGRFGPYLLHDGKYGRLSSTAEIFEVGMNSAVAKLADAANRGGRGASSREPLKVLGKHPRTEAEIKLMAGRYGPYVTDGTTNATLPKTIEQDALTLEEAAQLIDARAAAAPAKKGKKAVAKKAGAKKPAAKKAPAKKKVAAE
(139) DNA topoisomerase 1 [Granulicella mallensis MP5ACTX8]
1
MAKNLVIVESPAKAKTIGKYLGSDYVVEASIGHIMDLPKNDIGVELKLRTFEPTLIVSPGKEKIVDRLKKLAAKSDAVFLAPDPDREGEAIAAHLKFQLLPSIKDKSKMRRVTFNEITKKAVKAAFEHTREVDENLVDAQQTRRVLDRLVGYQISPLLWDKVRRGLSAGRVQTVALRLIVEREREINAFNPVEYWNIDAVLAPEKNGQEFTARMVGVKGLPIRVSNGTDAEGKEQFLSNALPDKEAVDEVMSQLEKATWRVRSIEKKERRQNPRAPFTTSQLQQQAAGRLGFNVRRTMGVAQRLYEGIELGSEGTVGLITYMRTDSTRISPDAVKDIRDWVQKKFGANYLPAKENVYKSKKDAQDAHEAIRPTSISFVPDEVRKYLSDEQYRLYKLIWERAVTSQMTPAIFDQTTVDIEAKADVSYDFRTTGSILKFDGFLRFDEEAKKARAARDAKASAAAIAEEKKTAAASADGDSAAEASKDATSEESSSERRLPELKDGQNLEKIKLDPQQKFTQPPPRFNEASLVKTLEEKGIGRPSTYASIINTIQERDYVKKLAQKLVPTEIGMVVTELLVKNFPYIFETGYTAQLEGELDAVEEGSEKWTDLLKGFYGHFEKELKVAETQMEDIKRMELETQEICDKCGSPLVLKWGKFGSFYSCSAFTKAKPITVAQGPFKKDPKAAVKKVLDTFQFPMRVKAMNDDVAEFSEEVADKSALMESLQRAAALGKKQSVKLVVEPESCDFTKENFSAKPDLNSPEADGEQEDEFCDNCGRTMVLRNGPWGPFMACPGYNEDPPCKTIRKLTQKVQSKPPVVLEEPCPKCGKPLLQRDGQYGEFVACSGYPKCKYVKQELLDVPCPKCGGEVAVRKNKRGDLFYGCTRYPKCDFTSNQRLVNETCPKCDSAYLVEYANSEGTFLICPNNREALPKRRPRKGAKEEEAPTTPECSFEKKIGPPKLKEAPAELTKPDPEKTKTLVEAMA
(141) DNA topoisomerase 1 [Leuconostoc citreum KM20]
1
MAESEKKKTTTTKKTKKTTTKTRKKNLVIVESPSKAKTIEKYLGSTYKVIASLGHVRDLPKSTLGVDVDNNYEPKYINIRGKGDIIKGLRQAAKAAKNVYLASDPDREGEAIAWHLQHILQLDDTAPNRVVFNEITKDTVKNAFKTPRLINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIKREKEIQSFEPEEYWTLDAVFKKGRSKIQSVFYGVDDKKQQLPDNDSVQDVLRRLNRNEPFEIGKVEAKERKRNPQRPFTTSTLQQTANTQLNFRTRKTMMAAQQLYEGINLGRGIGQTGLITYMRTDSTRISEMARHAATQYIHETWGEEYAQHRLVKQPSAEGIQDAHEAVRPTDVTRTPDSIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTITQNGVLFRANGSKTKFPGFTKAYPAAKEKDNTLPHLEEGDQVKIEQTDPEQHFTQPPARYSEAALIKALEENGVGRPSTYAPTLETIQKRNYVRLDARKFVPTELGEIVQTIVEESFPDVTNTQFTARIEHELDEVEVGAKYWVPVIDEFFKPFSKEVEKAETTLEKIIMHDELAGIDCSVCGAPMLVKMGRYGKFYACARFPDCRHTETIVKEIGLLCPKCHKGQIVERKTKKQRTFYGCSRYPDCDFVSWEKPTDKTLPDGTTPKENSKNQAKTTD
(142) DNA topoisomerase 1 [Alistipes shahii WAL 8301]
1
MQENLVIVESPAKAKTIEKFLGKDFIVKSSFGHIRDLAKKDLGINIGEGYKPVYEIPGDKKKVVDELTKLAKSKTVWLASDEDREGEAIAWHLTEVLGLPVDRTKRIVFHEITKRAILEAIEKPRTVNMDLVNAQQARRILDRLVGFELSPVLWKKVRPALSAGRVQSVAVRLIVEREREIIAFRSAAYFRVVAQFYAAGDPEKTLFKAELSSRFETEAQAETFLQSCIGATFTVAKAEEKPAQRYPAPPFTTSTLQQEAGRKLGMSVSQTMSVAQHLYEQGLITYMRTDSVNLSQQALAQCKEEITKLYGEKYSRWFNYKTKTKGAQEAHEAIRPSYIERQEIEGTPAEKKLYDLIWKRTVASQMVCAELDRTTITIDMSGSSNQFVAQGEVVRFDGFLRLYSESTDDDQAAESGEGLLPKLTAGDRVLPSQITATERFTSAPARYNEASLVKRLEELGIGRPSTYAPTITTIINRGYVVKQNRDGQKRNYAQLTLTGEKIASKTLSENYGKEKNRLSPTDIGMVVNDYLEEQFGPIIDYNFTASVEKEFDRIAEGDITWDKMIDEFYGPFHKMVDSAITTQTAKTREVRILGNDPKTGHIVKARIGRYGPMVEIEGNEGEKGRFASLKKGQLIESITLEEALELFALPRDLGQLDGEELMVGIGKYGPYVRYGKSFASLAKTDDPYTIGYDRAVEIVRAHQAAAAAANTPMKSFPEDADMLVKNGRYGPYIAYKGKNYRLPKGAKPEELTLDDCLKIVAGSKK
(144) DNA topoisomerase 1 [Gallionella capsiferriformans ES-2]
1
MAINLLIVESPAKAKTLKKYLGNDYEVLASYGHVRDLVPKTGAVDTENGFAMNYETIARNSKHMDAIAKAAASAENILLAPDPDREGEAIAWHIAELLKAKRGFKGKNMKRVVFYEITQSAVQAAVANPREIAMPLVNAQQARRALDYLVGFNLSPLLWRKIRPGLSAGRVQSPALRLIVERELQIEAFKTQEYWSVHLDTQKNHQSFSARLIQYQGKKLEQLSIASQSEYDAIYAKLNDAKLPPKVVKVEKKAKQRYAAAPFTTSTLQQEAVRKLGMSAERTMRTAQSLYEGVDIGGQTVGLISYMRTDSVSLANEAVAEIRNYIGDHFSSEYLPGTPPTYKSKTKNAQESHEAIRPTSIVRTPDSLQDRLTVDQARLYEMIWKRTLACQMTAARYDTVSADIRLGGDDTLFRANGQVLVFPGFISVYMEDVDDAEEEQGSRLPPLVEGDILPVDKLFGEQHFTQPPPRFTEASLVKSLEEYGIGRPSTYATIISTLQTREYAILDKKRFMPTDVGRVVTRFLTDHFTRYVDYNFTASLEDELDEVSDGKRDWIGVMDEFWKGFSALIKEKTNIERPQELLDEACPECGKPLAKKLSRYGSFISCTNYPECKYKRSVGGETQEEVRVELGVHPESAQAVLLLRGPYGHYVQLGEVIEGEKAKPKRVSWPKEMAVDQADLESALKLLSLPKDLGLHPETNKKVIVNIGRFGPYIGHDGKFKSIPRTDSIFDVTLDRAVELLAQAKDGNTVLRTLGDHPVDKTTVEICSGRYGPYARHGKINATLPKDVSPDEITLEQALELIAAKAAKGDTKPARKSAAKPKATAKPKAAAKPKAAAKPKAAPKAEAKPKAAAKPKAAPKAAAKPKAAAKKA
(145) DNA topoisomerase 1 [Ilyobacter polytropus DSM 2926]
1
MAKKNLVIVESPAKAKTIEKILGKNYEVTASFGHIRDLPKSKIGVDIENNFEPSYSTIKGKGEITKALRALAKKSNKIYLASDPDREGEAIAWHIAHILKLDEGESNRIEFNEITKTAIKDAVKNPRKIDIDRVNAQQARRILDRLVGYKISPLLWKIISSNTSAGRVQSVALKLICDLEDSIKKFVPEVYWEVSGDFTGGINLNLNKIDNKKVDKIKDEEIIKQLKKEIPGKSFEVTSAKISDRSKKPPLPLKTSTLQQLASSYLGFSASKTMRVAQTLYEGLNIDGNQKGLITYMRTDSTRISDEAKESAKVFIEEKYGKEYVGNYTEKKGKGKIQDAHEAVRPTDVLLEPLKIEKHLNTDQFKLYRLIWERFIISQLAPVKFKQFELLTNYDKYQFRGVANKIIFDGYYKVFKGEDAIESVKFPSIKQGDALVLEKLGVKEGITKAPARLTESSLVKKLESEGIGRPSTYASIIETLKKREYVVSEGKSFVPTSLGYEVKENLQENFPHILNVKFTAGMEEKLDRIEEGELDWKETLKEFYDDLSKYLTVFEKKVEEMENRIIVSDVLCPCGKGKMLMKSGRFGRYLKCEDEECKEKFSLKGIDIPKEQIEKGEIIVNEIVQEREKLKRGKPTDVYTDKGANLFLKAGRFGSYLESENFAEDEIRTPLPSEVRKMLAENRVIEKDGVVQLNSILKKIEEEEAELIRKAGPCEKCGSPFEVKRGRWGKFLACTGYPECKNIRKLPNDKKKEANKKK
(154) DNA topoisomerase 1 [Desulfovibrio magneticus RS-1]
1
MGKDLIIVESPAKVKTIKKFLGNAYAVEASVGHVRDLPSKKLGVDEKDDFAPQYQIIPGKQKVVSKLKEAAASASTIYLAPDPDREGEAIAWHVAQIVQEAGVPVHRIQFNEITAKAVREALSHPRDINEKLFLSQQARRILDRLVGYKVSPILWQKVKSGISAGRVQSVALRLVVDREKERRAFVPVEYWNFKARLAADSPPEFEAELAKYQGKKLEIGSAEAAAAAEAAITGQPFVVTAVTEKERKKSPPPPFITSTLQQAANQRLGYSAKRTMGAAQKLYEGLELGDSGTVALITYMRTDSTRIADEARDAAREYITEALGPDYYPEKARHFRSKAGAQDAHEAIRPIDVRITPADVKTLLPKDLFSLYKLIWERFVASQMAEARFWDTAVDVTAGPGLFKAKGQRLIFPGYLKVYGQEAGDEAKSLPKLDKGQELTLLELKKEQKFTQPPPRYTEASLVRELEEKGIGRPSTYAAIISTLIDRDYARLEEKHFVPSELGETVSDLLAEHFVKIMDVGFTAGMEEALDAVADGRTDWVNLLKDFTEDFNPTLAKAAKDMAKVKAGKETDVKCELCGKPMVIRFGKAGEFLGCSGYPDCKNTKEFDRAPDGAVIPRERKAEEVASVGACPTCGKDLVVKKSRTGSRFIACTGWPDCKYTKPLSTGVPCPKEGCSGTLVEKSSKRGKVFYACDAYPQCDFAVWDWPINEPCPQCDSKILVRKKTRDGELITCPSKSCRYKRAVGGKKDEGEGEE
(155) DNA topoisomerase 1 [Bartonella quintana str. Toulouse]
1
MNIVIVESPAKAKTINKYLGSQYKVLASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAASKRLNEIAKAVKEADSLILATDPDREGEAISWHILDILRQKKVLKDKPVKRVVFNAITKKSVLDAMNNPRDIDTSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTDLKTIRNEGFQARLTMFNHKKIGKLDIQSQEQADQMRHMLESAKYHTLSVEAKHTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGVEINGEMAGLITYMRTDGVQIAPEAIDSARKVIHEFFGSDYVPEKPRFYSTKAKNTQEAHEAIRPTDFQRIPNQVRNFLDTDQVKLYELIWKRAIASQMRSAEIERTTVEIEAQQGENHANLRATGSVIRFDGFISVYTDQRDEENSEENEITHLPQINTGETLTKEKVEAIQHSTEPPPRYSEASLIKKLEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRNFWDGFNASITNIQELRITNVLDVLNITLAPLIFPGREDGNNVRSCPLCSSGQLSLKLGRYGAFVGCSNYPECKYTRQLGTDPGEEKEVMRNDEPVMLGIDPKTGKDVSLRNGRFGPYIQVGEQKEAKRVRLPKEWQTEKMTLDKALALISLPREIGIHPETGKIITATIGRYGPYLAHDGKYAPLLHADEIFDIGINRAVTVLAEKQENKTKRNRTKTAALATLGDHPDGGTVTIRNGRYGPYVNWGKINATLPKDKDPISVKLSEALELISDKASSKKTTAKKASSKRKET
(161) DNA topoisomerase 1 [Chlamydophila felis Fe/C-56]
1
MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKTFGIDIEHDFEPDYQILPDKQEVINQICKLASSCDVVYLSPDPDREGEAIAWHIANQLPKNTQIQRVSFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIRVFLQDPKTSKTFWAHLYSADGKKWEKELPKGKTEDEILLINSEAKAQHYAELLEDASYRVTRVEAKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNNVRDYIQDTFGQEYLPKTPNLYTSKKMTQDAHEAIRPTDIHLSPDKLQGKLTNDQHMLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKIDDDVAEEENPSLPQLHAQDILDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVVTDIDCSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVETPWDSPCPVCGGEMKVRHGRFGTFLGCLNYPKCRGTISLHKKGEEVETEEPIPCPAIGCSGKIFKKRSRYNKTFYSCSEYPDCSVIGNTIDAVITKYTGTQKTPYEKKTTSKKKSTTKASSKTTKTTAKKKKSAKETTKTPKAGSLLIPSPQLAQMIGNEPVARGEATKKIWKYIKDHNLQSPENKKMLIPDDKFRGVIGPEPVDMFQLPKLLNQHLFKSG
(162) DNA topoisomerase 1 [Candidatus Pelagibacter ubique HTCC1062]
1
MNLVVVESPAKAKTINKYLGDDYIVLASYGHIRDLPSKNGSVDPENNFKMEWEVDSFSKKYLKEITDAAKISSKIILATDPDREGEAIAWHVKEYLNEKKLIKDKHIERVVFNEITKKAVIHGIENPRQIEPLLVDAYMARRALDYLVGFNISPILWTKLPGSKSAGRVQSVALKLITEREHEIELFDPEEFWTLSIQFNDSNKNSILASITQLNDKKIEKFSFKNKAEIDKAMKEVKSKNFNINDISSKVVNRNPSGPFTTSTLQQVSSGRLGFGASRTMQIAQKLYQGIEIDGETIGLITYMRTDGTNLSTDAIDTFRKYIKNEFGDEYVPDNAASYSGKKAKNAQEAHEAIRPTDIMRAPDTVKKYLSPDQHKLYDLIWSRALSSQMKPAQFDRNTITITSDDNGTICKASGSVIKFDGFLKVMKDTKKDDDEDILPEMNKGPVNIESLLDEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASIISVISTRGYAETINKRFHPTDRGKLISAFLEKLFSKYVDYNFTASLENQLDDITTGKEGWIKVLELFWKDFNQNVSDVKEKRTREVLDLLNDSLGSLIFERDTEGNINRQCKLCNGGSLSLKNSFRGGAFIGCSNYPDCKFTRPLSKAKAAAQSQLAEPKFIGKHENGNDMYLKNGRFGPYLQYEKIEEIKDEIIIETKKKKKTKKKKIEKEDNNLRNVSIPKGITLDSVDLDRAKFLCSLPKSLGINPENQRDIILNSGRFGPYLKCENKSARIENVEEIFSIGLNRAITLIAEAKPGRMSASIIKDLGEHPEDKKPVRVMKGQYGPYIKYKSLNATIPEEKDPLELNMEEALILIEKRKEYDKNKKVKKKKKK
(167) DNA topoisomerase 1 [Methylobacterium sp. 4-46]
1
MKVVVVESPAKAKTINKYLGHDYEVLASFGHVRDLPAKDGSVDPEQDFKMLWELEERGAKRVSEIARAVKGADTLILATDPDREGEAISWHVLEALQAKRVLKDVAVERVTFNAITKDAVQTAMANPRQIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIEAFKPREYWSLVATLATAKGATFEARLVGADGKRIQRLDVGTAEEAEAFRRDLELATFAVASVESKPAKRHPQPPFTTSTLQQEASRKLGLAPAQTMRIAQRLYEGVEIGGETVGLITYMRTDGVDMAPEAIRDARRVIGAEFGDAYLPGAPRSYSVKAKNAQEAHEAVRPTDLGRLPKEVARFLEPEQAKLYELIWIRTIASQMESAELERTVVEIAAQVGPRRLDLRATGQVVRFDGFLTLYQEGKDDEEDEESRRLPPMQAGDPLRRERVAATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQVLRDREYVRLDKKRLVPEDKGRLVTGFLESFFQRYVEYDFTADLEEQLDRISNAEIDWREVLRDFWRDFSAALAGTKELRTAEVLEALNQLLGPHIFPPRADGANPRACPNCAGGTLSLKLGKFGAFVGCSNYPECKYTRQLSAAGLDGDGEGSAGEGGQPGVRVLGEDPATGLPVTLRDGRFGPFVQLGEASAEKGAEKPKRSSLPRGLTPADVTLETALKLLALPREVARHPESGEPILVNLGRFGPYVQHGKTYANLGKDDDLLEIGANRAIDLIVAKEQGGGRPAADPGRVLGNDPEGRAVTVKAGRYGPYVTDGEVNATLPKGADKEALTLEEALRLIVARREAGGGTKKKTSGRARAARKTEAKPAAKAKAEKAAKPAAAGKSASAGKSASAAKSATAPEKAPARKKAAAAE
(170) DNA topoisomerase 1 [Sinorhizobium fredii NGR234]
1
MNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLILATDPDREGEAISWHVLDLLKKKKVIGDKPVKRVVFNAITKKAVLDAMADPRDIDISLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLQPKAVGNGEEANRLKALLDGASYVVESVEAKPVKRNPGPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDVGGETVGLITYMRTDGVQMAPEAIDAARRAIGSQFGTRYLPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDEVRRFLDGDMLKLYDLIWKRGIASQMASAEIERTTAEIAADNGGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDESGRLPEINARENLAKQKINATQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATISTLVDRDYVEIDKRKLMPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLREFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRTCQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSNGDAEAAVSNEPQSLGKDPHTGEEITLRSGRFGPYVQRGDGKDAKRASLPKGWTPATIDHEKALALLSLPRDIGKHPETGKMISTGIGRYGPFVLHDGTYANLESVEDVFSIGLNRAVSALADKQSKGAGGGRTAAAALKELGEHPDGGVMTVRDGRFGPYVNWGKVNATLPKGKDPQSVTVEEALALIAERAAKGGVSKGKAGNGKAARGRSSTAATKSTAAKAEKPKAAAKAKSKTAAKAKKG
(174) DNA topoisomerase 1 [Sphingobacterium sp. 21]
1
MAKNLLIVESPAKAKTIEGYLGKDFLVKSSYGHIRDLVKTDDAIDTANNFEQKYEVPADKKAVVSELKKLAKSAETVWLASDEDREGEAISWHLYETLNLKESSTKRIVFHEITKPAILKAIEQPRKIDFNLVNAQQARRVLDRLVGFELSPVLWKKVKPSLSAGRVQSVAVRLLVDREREINKFEPEAAFRVVAIFFTEENKKELFKAELSKRFATINEAEKFLNDCIPASYHVKSLETKPSKRNPAAPFTTSTLQQEASRKLGFSVARTMTVAQRLYESGKITYMRTDSVNLSDTALQAAEQEIRSAYGDKYHKRRQYKTKSAGAQEAHEAIRPTYFNQHTIEGDHSEKRLYELIWKRAIASQMSEAEFEKTTAKINISTRNEEFTASGEVMKFDGFLKVYFESTDEESEVNLEESDDNALLPPLRNGQQLGLKEMTATERFSRPPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVVKEDREGKQREYNVLTLGHGKVNTTKKTEITGAEKSKLFPTDIGILVNDFLVEHFKDIVDFNFTATVEKEFDEIANGLKEWTAMLHNFYGPFHKEVTDTIENADRASSERILGTDPQTGKQVSVRIGRFGPLVQIGSADDEEKPVFASLRSGQMIETISLEEALELFKLPKKVGKYEDKEMTVAIGRFGPYIRHNNAFYSLPKGIDPMDVNETQAIEIIELKRKKDIEKVIKTFDENPEARIEQGRWGPFIRFGKQNIKIPKDKDVDKITYNDILQLAESDKSNTGTKKKVPAKGKSKTAKKK
(178) DNA topoisomerase 1 [Streptococcus macedonicus ACA-DC 198]
1
MATTTTTKAQTAVKKSSKKTTKKKTAAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINNLKKEAKKSKKVYLASDPDREGEAISWHLAHILDLDENDKNRVVFNEITKDAVKNAFIEPRQIDMNLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGFFKKGTKKFQASFYGIDGKKLKLETNEDVQKVLALLTSDEFTVAKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGISLGKSGTQGLITYMRTDSTRISPIAQNDAANFITERFGEKYSKHGSRVKNASGAQDAHEAIRPSNVNLTPESIAKHLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVNLEQNNVRFTANGSQVKFDGYLAVYNDSDKNKMLPNMVEGDIVKKVSTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVRLAAKRFEPTELGEIVNNLIVEFFPDIVDVKFTADMEGKLDEVEEGKQQWQKVIDEFYKTFEKELAKAETEIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVTCPVCGKGQVIERKTKRNRIFYGCDRYPECEFTSWDKPVGRSCPKSGDFLVEKKIRGGGKQVVCSNEECDYEEAKIK
(180) DNA topoisomerase 1 [Clostridium sp. BNL1100]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAVKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATKMICDREDEIENFESQEYWSITAKLTKPKASPNFEARFYGIGKEKIELTNEEQVNSILDEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGFTTKRTMMVAQQLYEGIEIKGHGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPENPRVYKNKSASQDAHEAIRPTYMDMAPEGLKEFLSAEQYKLYKLIWDRFISSQMSSAIYDTVAADITAGKYMFKANGSKVKFPGFMVLYIEGNDVEGKDEDGEQNEKENNLPQLNEGDILELKKNTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAQMESELDDVEDGNKEWKAVMRDFYSSFAGVLKEAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNTKPIVEEAGVECPLCKGKVLIKKTKKGKKYIGCERNPECSFMSWDMPSPNKEMCPVCGAFMLQKSSGKKKALKCSNDKCTSNTETSTDTK
(183) DNA topoisomerase 1 [Starkeya novella DSM 506]
1
MQVVIVESPAKAKTINKYLGPGYEVIASYGHVRDLPAKDGSVDPEHDFHMLWDIDPKAQKRLSDIARAVKGADGLILATDPDREGEAISWHVLEILKEKRALKDQPISRVVFNAITKQAVLDAMAHPRTIDAALVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIETFVKREYWSIAATLATPRNETFEARLVGADGKKITRLDVGTEAEATDFRKALESADFKVRSVEAKPARRHPYPPFTTSTLQQEASRKLGLAPAVTMRIAQRLYEGVDVGGETVGLITYMRTDGVDMAPEAVAQARSVIGRDYGDRYVPNAPRKYTAKAKNAQEAHEAVRPTDLSRRPKDVSRHLEPEQAKLYELIWLRTVASQMESAELERTTVDIDAKAAGRALELRATGQVVKFDGFLTLYREGIDDGDEDEENRRLPAMSTGEALANKGIKADQHFTEPPPRYSEASLVKRMEELGIGRPSTYASVLAVLRDREYVKLDKRRLVPEDKGRLVTAFLESFFDRYVEYDFTADLEEKLDLISNGELAWKDVLRDFWRDFTAAVGETKELRVSDVISALDEMLTAHIFPPKEDGSDPRICPTCGTGRLSLKVGKFGAFIGCSNYPECKYTRPLAVQNGDSDNPAEANGTRVLGTDPVSGLEVTVRDGRFGAYLQLGEAKDGEKPKRSSLPKGLAPADVDLETGLALLSLPREIGVHPDNGEPILAGIGRFGPYVQHGRTYANLEAGDDVLSIGLNRAVALIADKQNKGPGRGRGAVGGRELGEHPTLGGQVTVRPGRFGAYVNHGKVNATLPKSMPAESVTLEQAVELITAKAGSAPAKPARRAAAKTASGDKPAKKAAPKKAAAKKSPAKKSG
(184) DNA topoisomerase 1 [Hyphomicrobium sp. MC1]
1
MNVVIVESAAKAKTINKYLGSGYKVIASYGHVRDLPAKDGSVEPDHDFNMHWEVDTKSQKIMREIAEAVKKADKLILATDPDREGEAISWHILQILNQKKALGKDTEVERVAFNAITKQSILAALKEPRKIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVCDREAEIEAFKTEEYWTIEALLSTAKNEDVRSRLVAIDGTALKKLDIKDEATATAIRKALLGQDFRIASVEKKATKRNPFPPFTTSTLQMDASRKLGFSAKQTMQIAQRLYEGVDIGGETVGLITYMRTDGVQIVPEAVSQIRDVISAEYGKNYTPFAREYKTKAKNAQEAHEAIRPTDPRRKPDQVRKHLEKDQAALYDLIWKRTIASQMAAADIEQTTAEIDVKGSDGKAYGLRANGSVLMFDGFLKVYEEGRDDRVRTIEKGKDDTADEDDDSRRLPPLAVGDRLKDKEISADQHFTQPPPRFSEATLVKRMEELGIGRPSTYASTMAVLVDRDYVRIEKKRLIPEDKGRLVIAFLESFFKRYVEYDFTADLEEKLDLISNDELEYKQVLRDFWRDFMAAVGEIKDLRVGDVLEALNEMLGPHVFPDKGDGSDPRLCPKCGTGRLSLKISGKYGAFIGCGNYPECNYTRQLTQSSDGDAAALDGKILGYNDDGLAVTMKTGRFGPYIQLGEAEGDEKPKRSSIPRGIDAATLDFERAMQLLSLPRDVGEHPDEGGMITAGLGRFGPFIVHEKDGAKTYVNLESLEDVFTVGLNRAVTLIAEKRAGGGKSRFQRNAPKVVKDLGQHPSEGGAVQVLEGRYGPYVTHNKVNATVPKAKNPAELTMDEAVALINERTANGGGKKGKPARGAKAKAAKDDKPAKAPKADKAAAPKAAKKPAATKTAAAKAEKAPAKKAPATSAGAKKLARAKA
(185) DNA topoisomerase 1 [Borrelia afzelii PKo]
1
MQKKKLIIVESPTKAKTIKKFLDNSFLVEACIGHIVDLPNNAKEIPKEYKKYEWANISIDYNNGFDPIYIIPSNKKPIVSKLKKLVKTINEIYLATDQDREGETIAFHLKEVLKIKNYKRMIFHEITETAITESLKNTRNIDMNLVNAGEARRLLDRLYGYTISPLLWKKIAYGLSAGRVQSVGLKLLIEKERTRINFKKANYYSILLQCKHEKKDLLLETKLEEIDGKNIAEGKDFTNETGKLKNSAKSIIITQDLMIELEKELENGQKIELISIETKKINIPPPKPFTTSTLQQEINKRLKIGTKQIMQHAQKLYEHGYITYMRTDSHNIAKIAKDKITKIIKNIYGKDYIEKKDRIYKKEKMTQNAHEAIRPSEMFIPNENIEIESKTAKEIYKIIWDRTIISGMKDAIKENIKLTFKYKNLIFKSNFTKIIFDGFLKHTKEKDEHLNINFDLIKKGDIFSIVKMQTSEHETKPPFRYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNTLIPTIKGAAVINLLEKYFPVLIELNFTSNMEEKLDKIAIGKLDKIKYLSKFYNGKKGLKDTVMQLEPKINSSEFRTVIESQNLENKDNSINYTINIGKYGPYLIFKGHNYSIITTTPLENLYKKDKIEKIINEKELKPNILGIDPLTGLNVIFKNTIYGSIVQLGEDTYAPQEYTKKGKPKKLKIIKAKKASAKKIDPENMTLELALKLLSLPKLIGKHPQTNEQIIAATGVFGDYIKTESGSIACSLKKDEKAYDITLDKAISLLNERVNKVGIIVKMIAFSKNKIGNKIYIYKKNDRFYAKIKRKKIDLPDNINLDEINEKYVFNLL
(187) DNA topoisomerase 1 [Azospirillum sp. B510]
1
MPGSNVVIVESPAKAKTINKYLGDDYTVIASFGHVRDLPARDGSVRPDEDFAMEWELGDRSKRHIDEIAKAVKSADRIYLATDPDREGEAIAWHLSELLREKHLSDNRDVQRVTFNEITKSAVQTAMANPRAVSQELVDAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICERESEIEVFKPQEYWSIAVGFTTPSGSAFTASLTQLDGKRLDKFGLPNREAAEAAVAKILPRSFAVSSVERKQSRRNPSPPFTTSTLQQEASRKLGFGATRTMRTAQKLYEGVDIGGETVGLITYMRTDGVSLSQEAIDGARGLIGSHYGERYVPDQPRVYKTAAKNAQEAHEAIRPTDLHRRPETVAAYLEQDELRLYELIWKRTLASQMESAVLDQVAVDIASPSDNGAKAVVLRATGSIVVFDGFLKVYQEDRDDAAEDEQQERRLPAMDQGDALARGDIAQDQHFTQPPPRYSEASLVKKLEELGIGRPSTYASILQVLQDRNYVRLDKRRFIPEDRGRLVTAFLENFFHRYVEYNFTAELENQLDEISDGKIDWKTVLRDFWTAFDVAVNGTKDLTITQVLTTLDNELGAHFFPAATEGGHDPRVCPVCREGRLGLKLGKMGAFIGCSRYPDCRYTRPLAVANDENGEAQEGPRELGNDPETGLPVTVRRGPFGAYIQLGPAPAAATPPEEPAAEEPAADGKKPKAKKKKKDEAPKPKRVSLPKGMAAADVDLDTALRLLALPRAIGNHPETGEEISAGIGRFGPYLKHGSVYKSLTADDDVLTIGINRAVDLLAGAAKKASAPAKTLGDHPKTGKPITMGSGRFGPYVKHASVYASIPKGTEPDSVTLEQALELIEAKVAKDAAKKGKAPKDAEPAKAEGAEAEKPAKAKVPAKKPAAKKATKAKAAKDAPAETAAPKKKTVKAS
(188) DNA topoisomerase 1 [Borrelia duttonii Ly]
1
MQQKRLIIVESPTKATTIKKYLDSSFSVEACIGHIRDLPNSAKEIPEEYKKFEWANLSIDYQNDFKPLYIIPSNKKMIIEKLKKLIKDQDEIYLATDQDREGETIAFHLKEVLQIKNYKRMVFHEITKSAIIDSLNNTREINMNLVNAGETRRILDRLYGYTISPLLWKKIAYGLSAGRVQSVGLQLIIEKEKSRINFKKANYYSITLECKHNKNNIQLKPTLEKIDNKNVAESKDFENDTGTLHEPNKTILIDKILMNSITKELKQINNIEVISIETKEIKLTPPKPFITSSLQQEINRRLKIGTKQIMSYAQKLYESGYITYMRTDSYEIAKTAKEKIKNIIRQKYGEEYIEKNDRMYTKAKMAQDAHEAIRPSEMFTPPEQIQIESETAKEIYKIIWDRTIESCMKDAIKKMGKIKFKYKNLTFKANFTKLIFDGFLKNNKEFHEDNIIDFSLIKEGDKFTILNIKPEQHETKPPLRYTEASLVQKLEKEGIGRPSTYATIISTLFEREYVFKQNNTLIPTIKGAAVINLLKKYFPILIELQFTSNMEENLDKIAIGKLDKIQYLNAFYNGKEGLKNTVSKIEPMISPEEFRMVYEYNNDKQFNYKINIGKFGPYLIFNGNNYAINLTTPLENLYKKDEIQKIITEKEIQPNILGVDPATGLNIIYKNSKYGGIIQLGEDIYEPQGFTKTGKPKKPKIIKAKKVSTKNIEYENITLELALQLLSLPKVIGKYPKTNEKIIATTGIFGDYIKTENDSIICPLKKDMKAYKITLEESIKLLDTKLAKNGIIVKIISLSKNKIGNKIYIYKQNDKFYAKIKRKKVDLPTNIDLNQIDATYVFGLM
(197) DNA topoisomerase 1 [Acidaminococcus fermentans DSM 20731]
1
MTNKLVIVESPTKAKTIEKFLGKTFTVRASMGHLRDLPKSQFGVDVEHHFTPKYINIRGKGPLIKELKTLAKKADKIYLATDPDREGEAIAWHLSYILGVDPAAACRISFHEITQTAIKGALKEPQAIDMDKVDAQQTRRILDRIVGYQLSPLLWRKIRKGLSAGRVQSVAVKIICDRQKLIDDFEPEEYWTSSVVLAPGKTPKITADVVKRDGKKLEIHNRAEADQVTEDLKKASYQVTDCAIRDRLRKPAPPFTTSSLQQEANKKMNFSTKKVMMLAQQLYEGVTLGRKGSVGLITYMRTDSVHLADAAVSEIRGYVDANYGPDYLPRKPNVYSSRKNAQEAHEAIRPTSVARTPEAVAPYLDRDQLRLYTLIWKRTVASQMASSISTLTTLTIAGDNYELRATGSVVKFDGFLKLADRKDEEKDKKVPALEKGTALNLIRVNEAVQHFTEPPANFTEATLVKELEEKGIGRPSTYSPIIQTILARGYVAKEGKKLLPTELGKLTIDMLTQYFSPFIDVPFSAHMESELDAISEHRTDKETVLQEFYGPFEKALKVADENIPVVEKPVIVSDVKCEKCGRFMVVKEGRHGKFLACPGFPECRNTKPILVKVGVKCPQCGGELIERHSKTGRLFYGCANYPTCRFTSWDKPTSEKCPQCGSMMVEHKERNGKTVLHCSNEKCPNASLRKK
(198) DNA topoisomerase 1 [Candidatus Vesicomyosocius okutanii HA]
1
MAKNLVIVESPTKAKTIEKFLGKDFSVKSSIGHIRDMPKKNMGIDIDNNFTPTYEITADKKKVVTDLRKAVKVAEKVYLATDEDREGEAIAWHLLEALNLPKDTPRIVFHEITKNAITHAISEPRIVNYRLVDAQQARRIIDRLVGFEISPILWRKISGARSAGRVQSPVVRLVVEREREISKHIDNSTYKVKAELSSESGEIFKVKLSKEFKSKKQVLAFANILLLANLTITSIEKKPFKRSPKPPFITSTLQQEAFQKLGFSVKQTMILAQNLYRKGFITYMRTDSFILSETAIEAVHKIIVREFGSEYHNTRRYKSKESRAQEAHEAIRPTDLTRSNIFDIEEQAAKLYILIYKRTLSCQMSDAQLQKTKIKINIEGLDEIFIANGEVLVFPGFLRIYDYLLSEDKLLPRLNKGNALNLVNFKARESFSRAKPRYTEASLVKKIEEMGIGRPSTYSTMVSTVQDRNYVTKKNGRGVEREYQLIEIKDNQVIQSQPSEVISGEKNKLFPTNIAYLLTDFLVKYFNNIIDYKFTAKLESDFDTIATQNISWQGVVKNFYIPFHQKIEDAVNISREEIHSMRNLGVDPKSDKPVSVRVGRYGAFVQIGHTDDKDKPTFASFRGLLDIESITLDEALELFNMPRHLGETDNFGTIKANYGRFGPYIQYGKKYVSLKEDIPEEVSLEKALELIKIKEKFDSERIIKIFDGSDIQLLNGRFGPYIWNGKKKGKGQKNITIKKVFGDKPIANLTLEECKKAISGKLKLKKKIVKKEVTKNS
(200) DNA topoisomerase 1 [Desulfurispirillum indicum S5]
1
MGKKKLVIVESPAKAKTINRYLGNNFTVKASVGHVRDLPKSTFGVDLENNFEPKYVTLRDKKKVIDELKSAASRVDEVFLASDPDREGEAIAWHISEILQKENKGLAIKRVLFNEITKKAIVQALEHPGEIVQPKVDAQQARRIIDRIVGYKISPFLWEKISRNLSAGRVQSVALRLVCEREKEIDAFVTEEYWSVVTQFIKDEVPFQAKLFRIKEKKAQIKDGDTAHAIVDALKKGSFTVGTVEKKQKRKRPMPPFTTSKLQQDASRKLRFSAKKTMMVAQSLYEGVNLGEYGQTGLITYMRTDSTRLSQDAIDMAREYIGKTFGPDYLPEKPRVYATGGKTQDAHEAIRPTTSLNPESIKAHLTGDQYRLYKLVFDKFLASQMADALIDATAADIINGDYTLRATGSVVAFAGHLALYQAVEESAKKEEDILPPLHQGDKLTSEDIQALQHFTQPPPRYTEATLVKTLEEKGIGRPSTYASILSTIEDRKYVEKEDRKFTPTERGKIVNELLVNHFPELFEYSFTANLEAKLDRIEEGEENWKDTLGNFYEGFQRELEKAKESLKHVDKINIKSGVACPKCEAELVIKSGRNGEFLACIRYPECEFTSNFTKEEDGSITIVQRPAEEMTSIACDKCGKPMAIKMSRRGPFLACSGYPECKNPKSFRREEDGTIVVVEKKPAEPTDIACEKCGAPMVIRASRRGEFLACSAFPKCRNTKNMERDEQGKAVIKEKKATAKEPGEKAAAPKAKAAAKKAPAKKSAAKKK
(206) DNA topoisomerase 1 [Elusimicrobium minutum Pei191]
1
MATKKTTTKKTESLSKGKNLVIVESPTKQKTISKILGADYVVKSSFGHVRDLPSKEIGVDEKNGFKPKYVPVEKAKKMVSELEKLAKGSEYVYLATDPDREGEAIAWHLVELLKIPVEKIRRIFFHEITPAAVKASFDHARNINKDLVDAQQARRVLDRLVGYKLSPLLWKKITGGLSAGRVQSVAVRLLAERAKEIENFREEEYYSLTSELEKQGETPKFNARMLKWRGKNTEIITTYHLFAEDYKVKTTVFKKPEDLAPVNSLLRQGPLTVSKIEKKEVKQKAKPPFITSSLQQEAYNKIGFPSQKTMMTAQSLYEGVEIAGEVVGLITYMRTDSFNVSKDLQSQTKKFIAGKYGDDFVPPTPNFFKSKVKGAQEAHESIHPTDVYKTPASIKDYLSADQYKLYELIWLRFIASQMADAVFNTVSVDITAGKAEECVLRATGRTVKFPGFLSVYKEDDSEEEDEGSALLPNLTEGDDLNLIDIVTKSHKTAPPPNYNEASLIKTLEKHGIGRPSTYAPTIKTILDRKYIIRQPKTNKLIVTDLGVTVTDQLKDFFKDIMDLSYTAGIEEKLDDIAEGDNDWVKVIGDFYEGFKKDLATADKDMQRAAPKPSDEKCPLCGSPMVIRRSRFGEYLACSTYPECKGKINLTSSGEKLAPEVTEEKCEKCGSPMVIRSGRRGKFMACSAFPKCKNTFSIDASGNKVASSGPIETKIKCEKCGKPMLLRASKRGEFLGCSGYPKCKTIVSVSPEEIAKIKKEHEAENK
(209) DNA topoisomerase 1 [Clostridium thermocellum ATCC 27405]
1
MADKLIIVESPAKAHTIGKFLGKDYKIVASVGHVRDLPKSQMGVDIENDFTPKYITIRGKGEIISKLKKEAKNASTIYLATDPDREGEAISWHLATLLNIDKNEKCRITFNEITKNAVKNAIKSPREINMDLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTITAKLLKGGVKAPFEAKFYGLDNKKTELKSEEEVNKVLDEIKDAVFVVQKVKKGEKKKNPNAPFTTSTMQQEASRKLGFSTKKTMMVAQQLYEGIEVKGVGAVGLVTYIRTDSTRISEEAQNQAAKYIKEKFGESYLPKEKNVYKNKSASQDAHECIRPTSVEMDPESVKDSLTKEQYRLYKLIWDRFVASQMAPAVYDTINADIEAGKYLFKASGSTVKFPGFTVLYQEDKDDETEEGEVIVPELAEGESLKLKKLEPRQHFTQPPPRYTEASLVKALEEKGIGRPSTYAPIITTILARGYVVKEGKTLVPTELGKIVTDIMKNYFQDIVDVEFTAQMEKTLDEVEEGEKRWVDVMRSFYSQFVDVLKNAEEKIGNIEVPEEVTDEICEKCGRNMVIKVGKKGRFLACPGFPECRNAKPILEDAGVTCPKCGGKVYIKKTRKGRKYLGCENNNSDPKCDFMTWDMPSKENCPKCGSFLLKKYSGRKVQLKCSNENCDYVKTGKEKKEDE
(217) DNA topoisomerase 1 [Gramella forsetii KT0803]
1
MAKNLVIVESPAKAKTIEKFLGTDYKVASSFGHIADLPTKEIGVDTEGDFTPKYVVSKDKKDVVKKLKGLAKNAEMVWLASDEDREGEAIAWHLAEELKLTQEKTKRIVFHEITKSAILRAIENPRDIDYNLVNAQQARRVLDRLVGYELSPVLWRKVKGGLSAGRVQSVAVRLIVEREREIKDFDPQASYRIDAEFSTEDGKSFKAKIPKNFDTKEEAEKFLKDNIGANFKVADLTTKPAKKNPAPPFTTSTLQQEAARKLYFSVGKTMTLAQRLYEAGHITYMRTDSVNLSEDARKGAKEEILKAYGDKYSKTRQFKGKSKGAQEAHEAIRPTGFQKHSISGERDQQRLYDLIWKRAIASQMSDAQLERTNVRIEADKHDNHFTANGEVLKFDGFLKVYLEGSDEEDEEQSGMLPALKVQQPLNNEFITATERFTRPPYRYTEASLVKKLEELGIGRPSTYAPTISTVQSRNYIEKGSVDGTERDYVQFKLKNDKLSEKKLSETVGSDKGKLVPTATGMVVNDFLVNHFSNILDYNFTAKVEESFDNIAEGNKEWTAMMKEFYKDFHPHVQDVAKNADREVGERILGEDPESGKPVSVRLGKFGPMVQIGSVEDEEKPRFASLSPDQNMESLTYEEAMDLFQLPKKLGEYKGEAVEVNNGRYGPYVRFGKKFVSLEKGEDPLNVDFERAMELVKEKEKADAPIYEYKEMPVQKGVGRFGPYLKWNNMFINVNKKYDFDNLSNNDIEQLIEDKLQKERDKLIQHWEEEGIRVEKARWGRFNVIKGKTKVELPKTTKADELTLEEVQAIIEKNTKKKKPAKKKSTAKKKSAAKKTTSKKTAKKTTKKK
(219) DNA topoisomerase 1 [Neisseria lactamica 020-06]
1
MAKNLLIVESPSKAKTLKKYLGGDFEILASYGHVRDLVPKSGAVDPDNGFAMKYQLISRNAKHVDAIVAGAKEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPREIEMDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIRAFEAQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQFDLPNEAAQADVLKELEGKEAVVTAIEKKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDSVNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPFLSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFAGFLSVYEESSDDEESEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEYGIGRPSTYASIISTLKDREYVTLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLEDQLDEIAGGKRQWVPVMDKFWKPFIKQVEEKEGIERAKFTTQELDETCPKCGGHKLQIKFGKMGRFVACAGYPECSYTRNVNETAEEAAERIAKAEAEQAELDGRECPKCGGRLVYKYSRTGSKFIGCANYPKCKHVEPLEKPKDTGVQCPQCKKGSLVERKSRYGKLFYSCSTYPDCNYATWNPPVAEECPNCHWPVLTIKTTKRWGMEKVCPQKECGWKEQIEPPAPKE
(233) DNA topoisomerase 1 [Bacillus cereus ATCC 10987]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMNLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIERLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAFGTEYIGTEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(234) DNA topoisomerase 1 [Hydrogenobacter thermophilus TK-6]
1
MNLFIVESPTKAKSIAKYLGNGWVVRATLGHIKDLPERELGVDIKTLEPKYVWLKGKKKIVDGIKKAAKKAKKIYLGTDPDREGEAIAYFLKEELLKVNTSIYRATFYEITKKAITEAIGGASDINLNLVSAQFSRRVLDRLIGYKLSPFLWRDLKERGLSVGRVQSPTLRLIVERERQIQNFKRKKYYYIKAEFVVDGVEFSAVFKQRFEKPSNAEPFMKKLKDVMFVVKSVSKEMQKEPPPKPFNTVSLQAEASKILGISVDKVQKMAQKLYEEGLITYPRTDSYRMNKEKAQEFMKYIERTYGKDYVGRLRKYKEKALAWGAHECIRPTSLDKKPESVLELKLWSLISSRALASLSSDAIREKFFVVLLALSDHTLEFTAEGSKLVFDGWTRIYPKEVKDRALPHLEEGQVIKPKRIYIEEVEVPPPPRYTEGSLVRTLENLGIGRPSTYATIIKTLKDRGYVVLEKGYLKPTEMAFKVVDYLMEKFPNLMDYGFTKYMEDNLDAVEEGKKDWKEVVRESYRRVLNAKE
(235) DNA topoisomerase 1 [Hydrogenobacter thermophilus TK-6]
1
MNLFIVESPTKAKSIAKYLGNGWVVRATLGHIKDLPERELGVDIKTLEPKYVWLKGKKKIVDGIKKAAKKAKKIYLGTDPDREGEAIAYFLKEELLKVNTSIYRATFYEITKKAITEAIGGASDINLNLVSAQFSRRVLDRLIGYKLSPFLWRDLKERGLSVGRVQSPTLRLIVERERQIQNFKRKKYYYIKAEFVVDGVEFSAVFKQRFEKPSNAEPFMKKLKDVMFVVKSVSKEMQKEPPPKPFNTVSLQAEASKILGISVDKVQKMAQKLYEEGLITYPRTDSYRMNKEKAQEFMKYIERTYGKDYVGRLRKYKEKALAWGAHECIRPTSLDKKPESVLELKLWSLISSRALASLSSDAIREKFFVVLLALSDHTLEFTAEGSKLVFDGWTRIYPKEVKDRALPHLEEGQVIKPKRIYIEEVEVPPPPRYTEGSLVRTLENLGIGRPSTYATIIKTLKDRGYVVLEKGYLKPTEMAFKVVDYLMEKFPNLMDYGFTKYMEDNLDAVEEGKKDWKEVVRESYRRVLNAKE
(237) DNA topoisomerase 1 [Blattabacterium sp. (Mastotermes darwiniensis) str. MADAR]
1
MKNNLVIVESPTKANTIQMFLEKNFHVVSSYGHLIDLPEKEIGIDIKENFRPNYVILPKKIKIVQNLQKLIKNYNTIWLASDEDREGEAIAYQIYKTLNIPNEKLRRIVFHEITKKAILNAIENPRLINYNLVYAQQARRILDRLVGFKLSPILWKKINYGLSAGRVQSAAVKLIVEREKKIQNFTPIPGYQIYGTFNHKKKITLHAKFEHKIEGKEKMKKILLSCINTNFFVKKIITKQENKTPPPPFTTSTLQQEASKKLNYSISKTMFLAQKLYEEGFITYIRTDSTSLSKEILSQIKNYILYSYGKQYLSKKEFSSNNKFSQEAHESIRPTDITKKTLETLELSQKRLYQLIWKRTVIGQMSDAKIETKYFYIQSSNIENFFIYTNKTIVFDGFMKIENARNENTYLSQIKKGTPLQEKEIIAKQIFTQHLPRYNEATLVNNLEKLGIGRPSTYVPIISTIKKRNYVNIQKYIKKIKLRECFFLKKNVIIEKKDKITEIEKNKFIPTEIGILTTDFLERNFQEIVDYNFTANLEKNLDNIAKGKESWHNVIKIFYEEFYNKIKKVKKNVEKIHKQRFLGFEPISNRKIFAKIARFGPIIQIGEFKDKKKPKFYPLLIHQKIDTITFRDSLKIIELPKYLGTFEEQKIFLKMNKYNIYIQHKNKIIPVEEKIFFDSLTLKKAIDIILENKKKNN
(240) DNA topoisomerase 1 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
1
MGTKTTTKPKTGTKKSTTKKKSAAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHILGLDPEDKNRVVFNEITKDAVKNAFVEPRQIDMNLVDSQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFVPEEYWSIDGLFKKGTKKFQASFYGLDGKKMKLSNNDDVKAVLAKLKGDDFLVSKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIHLGENGTQGLITYMRTDSTRISPVAQNDAAQFISNRFGANYSKHGNRVKNTSGAQDAHEAIRPSSVNHTPEAIAKYLNKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLEQNGVLFVANGSQMKFDGYMAVYNDSDKNKMLPEMEEGETVKKVSTSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVAFTAEMEGKLDQVEIGEEEWQHVIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGHPMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPICHKGQVIERKTKRNRIFYGCDRYPECDFTSWDLPVGRDCPKSGDYLVEKKVRGGGKQVVCSNETCDYKEEKIK
(243) DNA topoisomerase 1 [Sphaerochaeta pleomorpha str. Grapes]
1
MDDTKVLIIVESPTKAKTITKFLPKTCKVVASKGHIRDLPEDRMAIDVANGFACDYKTVEGKESLIRELKSSLKGVDKLLLATDEDREGESISWHLLEVLKPKIPYQRMVFHEITKGAIQKALESGRDLDLNLVQAQEGRRIVDRLYGYTLSPTLWKKLANKRLSAGRVQSVGLRLTVERERQRIAFTKSSYFDAKVDLLSSDGQQFEAKLFSYQEKSIAQSKDFDSVSGIYKGKASVLLLDKNQLHAIVQDLNGAPYEIVDIQRKPFLTRPNIPFTTSTLQQDAIKKLHFSASDTMRIAQKLYENGFITYMRTDSPALSSEGTQAARLLVKQLYGPDFLSPTERHFAAKTAGAQEAHEAIRPSGERFRVPGETGLSGRELALYELIWKRTLASQMADAKKATTSVSIQANDALFTATGTQIVFPGFLRAYVEGSDDPDAALEDKESLLPPLSVGEICPLVKLSEVEHQTKPPARYTEASLVQELEKRGIGRPSTYATIIKTLLDRKYVVKDGPALAPTFIGFGVCQYLEDYFAQFVDYDFTSTMESGLDQIASGQLDKESFLEKFYLGAEGLENQNTLQLAQDNKVTSKTIRLSQISEENPIMIGPYGPYVLGSEVEGKAQYLSLPLDWTPGNITDEDVKALIARGKVKAEPEILGTGKVAGLPVQLLNGRFGPYWQEGEGKDAKRASIPKWVMDAEKQHELEIANRYLSLPRLLGKDKDGNDIVAAKGKFGPFISCNGEFRNLRKTDHDAQLFSITLEEALALLAEEKPKAGAKGKGKGSSSSAVVRQIGEFEKEPVALAIGRYGYYLKVGKDNIALPPKYKHDDELAKAISLEDAAEIIRTKRAKDSEE
(244) DNA topoisomerase 1 [Caldicellulosiruptor owensensis OL]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDNQEFKAKFYGDKKGKIELKNQGQVQEIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAIAQMLYEGVEIKGEGSIGLITYMRTDSTRISEEAQQAARNLIMQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTPDQYKLYKLIYDRFLASQMESSIYDVLSAELEVEGYVFRLTGSKLKFAGFMEVYVEGKDTEDEEEESQLPEISEGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTDVVRKYYQPLEKELEIARNTMNKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYHCLEVLCPKCRKRIIERKSKKGKKYYTCEEYPACDLILWEKPVKNCPKCGSLMYEKGRKGNKKLVCSNENCLHEEKIGEKGE
(247) DNA topoisomerase 1 [Paenibacillus polymyxa M1]
1
MADSLVIVESPSKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFNPKYITIRGKGSILKELKDARKKVKKVYLAADPDREGEAIAWHLAHALELDDTADCRVVFNEITKQAVKDAFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIILDRENEINEFVPEEYWTITAKLAIKDSTFEAKFHKLHGEKKELSSEADVQEVLEAIGKSSYKVRDVKEKERLRNPSPPFTTSSLQQEAARKLNFRASKTMSVAQQLYEGVDLGKEGTVGLITYMRTDSTRIATSAQEEAKEVIVQKYGEDFVPESPRQYSKKSANAQDAHEAIRPTSALRDPETVKPFMSRDQFRLYKLIWERFMASQMASAIMDTLSVDIEAGEAIFRAAGSKVRFPGFMKVYVEGNDDGKTEEDKLLPPLQPGDKLKKESVEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLETIQKRGYVAIEEKKFFPTELGELVIEQMEEFFPEILNVEFTANMEGDLDHVEEGEGDWVKVLSDFYESFEKRLEVAEEEMKEIEIKDEVSDVICDKCGSPMVYKLGRFGKFLACSAFPDCRNTKPIVKDIGMNCPTCGEGHVVERRSKKGRVFYGCDRYPECDFVSWDKPSIKPCPSCSGLMVEKRTKQGTKLNCTVCDHSEMLEESDESVETS
(255) DNA topoisomerase 1 [Parachlamydia acanthamoebae UV-7]
1
MAKALIIVESPAKIKTLKKFLGPNYIFESSIGHIRDLPEKEFGIDVDHDFEPKYVIMPDKEKVIANLRKAAKSVDTVYLSPDPDREGEAIAWHITQILPDSTKIKRVSFNSITKEAVVKALESPREIDFALVNAQQARRLLDRIVGYKISPILNRRIQRGKEGFVSAGRVQSVALKMVVDREKAIEVFKPVEYWNLAAILKTKEELKNFRASLHSIAGKRIEKEPIEGKDVVIIDSKEKADAILAKMKSQSFYVVKVERKEKKRNPVPPFITSTLQQEASRHYGFSSARTMNIAQTLYEGVDLGNEGSEGLITYMRTDSVRIAPEALAEARQFILNKYGKDFLPSEARNYSTSKSAQDAHEAIRPTNLAHPPEHLKDYLTREQFLLYELIWKRFVASQMTPAIYDTVSADISAGEEILLRATGSVMKFQGFLVLYEEKEDDEDKNEERMLPHLEEGQLLQLIELTSEQAFTRPPPRFTEASLVKELEKCRIGRPSTYATIMNKIQSRDYTIKESGRLKPTELGMVIVNMLENNFQEIMNVGFTASMEDGLELIAENQQDWKGLIRDFWLKFVPTLEEAEKSAFVPKVMTDIDCPSCGAKLQKVWSKSKYFYGCSRYPDCNYSAPIEEISFNKDDYAEDFDWDQKCPDCQSDMKVRHGRFGAFLGCTRYPDCRGIVNIPKKGEVVIPAAEMPACVAIDCPGHMVARKSRFGKTFYSCSTFPECDVIVNELSQLQEKYHNHPRTAYVKKAGKGKKEATKKRAASSTKKATTSKKAAAPKEKKASTRQQPLQDLSPELAQVVGANEMSRGDVMKKVWDYIRAHQLQDSANKRQINPDATLAKVFGGPEPMDMFKMTAVLGKHIHKKQ
(256) DNA topoisomerase 1 [Marinitoga piezophila KA3]
1
MPKTAKKIVIVESPAKAKTIEKYLGSEYKVVASKGHIRDLPQKKFGVDIEKDFEPEFELMPGKEKVVEDLKKIAKGKTVYLAPDMDREGEAIAWHLSYLLGLDENEENRIIFSEITKNTIQEAIKSPRKIDKNKVGAQLARRILDRIVGYKISPILWRILKDYNTSAGRVQSAALKILVDRERQIFKFKPKEFYKIFLKYMEQDIPLVKIDGKKFKKESISEKKKEEIFKELENAIYSVTAVTEKETKKNPPQPFITSTLQQSAISKYGWSSQKTMQIAQKLYEGIETKEGPIAFITYMRTDSTRISEDAMKKAHEYLESNFGKEYTGHFKVKKSKKKIQDAHEAIRPTDVFMDPKKAKELISGDALKLYTLIWNRFMASQSAPSKYIEKTYTISDNNKKYEFEAVGRKRIFDGFEKFWSSSTTEKEYEIPEKGILENIELKAERDETKPPSRYTEASLVKEMESKGIGRPSTYATIITTLLNRKYVIKEKNSLIPTLVGFVVSDILEMNFPEIVDVKFTAHMEENLDKVESGEMDWKTLLKEFYAEFEKFLNDTDKKLKERSMDFTYNTDISCEKCGEKMQLQFGRYGLYLKCPKCGENKGIQKGALGVTIDKKVYLDESFLKTEKGKEEGIGRQCPKCGGELVIKSGRFGKFIACSNYPECKYTEPLPARGKCPKCGGTVHKMKSKKGKVYYKCSECGEMFWDEPSDYRCPSCNGPLFYKRKNREEMLYCPEEKKYFKESEINEL
(261) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-mouse-Japan]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVSVEDDYEPNYINVRGKADLIKSLKKASKKSEKVFLATDPDREGEAISWHLAYILGIDVDDKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINSFEVKQYFTIEGSGKKNSKKYVFKLHSKHKEKLDELTENKVLEILDELSEGKYIVDEIKEGSKNKYPSPPFTTSTLQQEAYKKLNFQTKRTMSVAQSLYEGVEVKGYGVVGLITYMRTDSVRLSADSLNQANEFVAKVYGDKYKLDIPRQYGKNNKNIQDAHEAIRPTNVEITPDIAKQTLKDDQYKLYSLIWRRFLASQMRNAVYNTMAISIKNGDYLFKLNGSQLQFDGFLKVYEVDKDDKDLILPAFEEGEELKNVKVESIEHFTQPPPRYTEASFVKLLEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIEFTADMEKKLDGIEEGKASWKSIVHEFYKPLKEKIDIAENTVKKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSIIQKLNIPCPKCGGEINVRKSKKGKVFYGCSKYPECDFISWNEPSNVKCPKCGGITVKKIKRKQEFYECIDQDCKDK
(263) DNA topoisomerase 1 [Streptococcus infantarius subsp. infantarius CJ18]
1
MATTTTKAQTAVKKTSKKTTKKKTAAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINDLKKEAKKSKKVYLASDPDREGEAISWHLAHILGLDENEKNRVVFNEITKDAVKNAFVEPRQIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIRNFKPEEYWTIDGFFKKGTKKFQAAFYGIDGKKLKLSTNEEVQEVLARLTSDEFNVAKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGISLGKSGTQGLITYMRTDSTRISPVAQNDAAGFITERFGENYSKHGNRVKNASGAQDAHEAIRPSNVNLTPESIAKHLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVNLEQNGVRFTANGSKVKFDGYLAVYNDSDKNKMLPDMVEGDVVKKVSTSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVRLVSKRFEPTELGEIVNNLIVEFFPDIVDVKFTADMEGKLDEVEEGKEQWQKVIDAFYKPFEKELAKAETEIEKIQIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVTCPICGEGQVIERKTKRNRLFYGCDRYPECEFTSWDKPVGRSCPKCGQFLVEKKIRGGGKQVVCSSEECDYEEAKVK
(264) DNA topoisomerase 1 [Synechococcus sp. CC9605]
1
MAHTLVIVESPTKAKTIRGFLPKGFKVEASMGHVRDLPNNASEIPASAKGQKWANLGVNIEADFEPLYVVPKDKKKTVRELKDALKGADQLLLATDEDREGESISWHLLQLLAPKVPVKRMVFHEITKEAIGKALDQTRDLDMELVHAQETRRVLDRLVGYTLSPLLWKKVAWGLSAGRVQSVAVRLLVQRERARRAFRSGSYWDLKAQLEQSGSAFEAKLTHVGGQRIATGNDFDESTGGLKAGSAVRLLSESEAKALAESVRSSAWTVDAVEEKPTVRKPVPPFTTSTLQQEANRKLRLSARETMRCAQGLYERGFITYMRTDSVHLSDQAINASRNCVETLYGKEYLSKGPRQFSTKARNAQEAHEAIRPSGESFRTPGETGLDGRDLAVYELIWKRTVASQMAEARLTMLSVDLSSGEASFRASGKRIDFPGFFRAYVEGSDDPDAALEGQEVLLPALSVGDAPEPKTVEPLGHQTQPPARFSEASLVKMLEKEGIGRPSTYASIIGTIVDRGYATLLGNALTPSFTAFAVTALLEEHFPELVDTSFTARMENTLDEISHGKVQWLPYLEGFYKGDEGLENQVQQREGDIDPGASRTIDLEGLSSVVRIGRFGAYLEAKRVSDDGEEELIKATLPREITPADLDEEQAELILKQKADGPEAIGEDPETGDLVYLLSGQYGPYVQRGQVSDENPKPKRASLPKGQKPEDLTLEDALGLLRLPRLLGEHPEGGRIQAGLGRFGPYVVWDKGKGDKDYRSLKGDDDVLAVGLSRAIELLAMPKRGRGGRTALKDLGKPEGSDETIQVYDGPYGLYVKQGKVNASLPEGKGADDVTLEEAVELLVAKAASKKGGRKTAAKKPAAKKPAAKKPAAKKPPATTKTGRLRASAVRVIKPADN
(266) DNA topoisomerase 1 [Cellulophaga lytica DSM 7489]
1
MAKNLVIVESPAKAKTIEKFLGKDYKVESSFGHIADLPSKELGVDVENDFTPKYVVDSEKKKLVKKLRDLANKAEVIWLASDEDREGEAISWHLAEELKLDKSKTRRIVFNSITKSAIQKAIENPREINYNLVNAQQARRVLDRLVGYELSPVLWKKIKPGLSAGRVQSVAVRLIVERERAIEAFTPEASFKVVAEFKTESGSSFSAKINKTFSSKKAAQDFLNKNIGANFSIANLDKKPAKKSPAAPFTTSTLQQEAARKLYFSVGRTMQVAQRLYEAGLITYMRTDSVNLSKEALDAAKEAIIQNYGKEYSEVRNYVGKTKGAQEAHEAVRPTDMKRQSPSLERDQARLYELIWKRTLASQMSDAQLERTNVKIKADKHKEEFTANGEVIKFDGFLKVYLEGHDDEETEEQEGMLPAMKVGEALLNNYITATERFSRAPYRFTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTIEGVERKYTQLVLEANNVEEKNLTETVGSDKGKMVPTDIGMIVTDFLVNHFETILDYNFTAKVEEDFDEIATGDEDWGKVMKDFYKDFHPKVEDVEQNADRASGERILGTDPKTGRQVSVRLGRFGPMVQIGTAEEEEKPQFASLLPEHSLGTITFDEAMELFKLPKDLGTYEGEEVSANVGRFGPYVKFGKKFISMEKGESALDITKERAIELIKEKQKADAPIASYEDMQVTKGVGRFGPFIKWNGMFINVNKKYDFDTLSYEDIVELIEAKKQKEIDKLIQEWPEEGIRIEKARWGRHNVLKGKIKVELAKTVDATKITLEEAKAMIEKKTPKKKTKAKAKPKAKAKPKTKK
(267) DNA topoisomerase 1 [Meiothermus silvanus DSM 9946]
1
MANKGTLVIVESPAKAKSIAKMLGTGYEVKASKGHVADLPERDLGVDVERDFAPEYEVKKDKKPVVDELKRAAKGKDVLIATDPDREGEAIGWHVARLLELDPSRPMRVEFHEITPRVVREAIRKPRPIDQSLVDAQQARRVLDRLVGYNLSPLLAQEFRRRALSAGRVQSVALRLLVEREAEIEAFVPQEYWTVAGLFESTQARFKAMLYSVEGERVQTAEKFLLTGEVQTREVVERIRQVPQWRISKIDRRERRRSPAAPFTTSTLQQAASGRLGWTAGRTMRVAQRLYEGIDLPEGTVGLITYMRTDSVRVSQEALAEVRKVIPQMFGQPYLPDKPNFYSAKKTASTQDAHEAIRPTSPSRTPDSVRSYLSEEEYRLYDLIWRRFVASQMTPAVFDQTTVTVEGGDFVFRATGSILKFDGFLKVWGRESEEEADNLLPRLDEGSPARLLALEPEQHFTEPPPRYTDASLVKTLEELGIGRPSTYAPTIDTLEKRLYLERNGKTLKPTPLGKDVVRWLVEKFPRVVAYDFTATMEDHLDQIEEGKVPWPKVVREFYEPFMEEVSRLPRRTCPVCGRPMEVKVSRFGQFLGCTGYPECRHTERLEAKRAAEPIGEPCPKCHQGELVRRHGRYGSFISCSRYPECDYSRDEAPSTGIECPKCHAGEIVQKISKRGKPYYRCNNCDFLSFDRVLESRCSICGWNEIQKGRDKTACSNPDCERYGGPDLKALSERRGNGKATPPRFAAKEASRSARRNHATNAKRKTLSAKGSNADGKKKKATQTSNKPAAWKDLEPFLARLNLPAQEAEIVRRTQGQQKAVPEAAKALNLPENEALTLFRKGMFKLRMAYGRSKKEAVTA
(269) DNA topoisomerase 1 [Flavobacterium psychrophilum JIP02/86]
1
MAKNLVIVESPAKAKTIEKFLGADFQVESSYGHIADLPSKEIGVDVLNGFTPKYEVSPDKKALVTKLKGLAKKADMVWLASDEDREGEAISWHLAEELKLDPKKTKRIVFHEITKTAILKAIENPREIDYNLVNAQQARRVLDRLVGYELSPVLWRKIKGGLSAGRVQSVSVRLIVEREREIINFKPVATYSVQAEFTNEAGKSFKAKLPKNFNTKKEAEDFLNKNIGSIYKVGDLETKPTKKTPAGPFTTSTLQQEAARKLYLPVGITMQLAQRLYEAGLITYMRTDSVNLSKDAMEAAQAEIIKSYGKEYAKPRTFVNKSKGAQEAHEAIRPTDMSRHTVNIDRDQARLYDLIWKRTLASQMADAELERTNVKIEANNHSELFTASGEVIKFEGFLKVYLEGHDDDEEEQEGMLPSMKVNEKLINNYITATERYSRAAARYTEASLVKKLEELGIGRPSTYAPTISTIINRNYVEKGNLEGQERNYTQLTLQSGKVGEKLLKENTGSDKGKLVPTDIGTIVTDFLVKNFDNILDYNFTAKVEQDFDEIAEGNMQWAKMMQDFYDKFHPTVKDVEANADRESGERILGIDPKSGKPVSVRLGKFGPMAQIGAADDEEKTFASLLKEQNIGNITLEEVLKLFLLPKNLGTYKGEEIEVSNGRYGPFIRFGTTFVSLPKGEEPLNVDLNRAQELIDEKLLADAPIAVYKGEGVQKGTGRFGPFLKWNGIFINVSTKYNFNNLSQQDIETIIEDKIQKNIDKVIHNWEAEGILVQKARWGRSEITKGKIKIELSKDFDAAKLTLAEAQEMIAKKTPVKKAPVKKAVAKKPAVKKLVAKKN
(272) DNA topoisomerase 1 [Chlamydia trachomatis D/UW-3/CX]
1
MKKSLIIVESPAKIKTLRKLLGEGFIFDSSLGHIVDLPAKGFGIDIENGFVPDYQILEGKKEVIRKICAEAKKCDVVYLAPDPDREGEAIAWHIANQLPKDTKIQRISFNAITKGAVTEALKHPREIDMALVNAQQARRFLDRIVGYKISPILGRKLQRWSGVSAGRVQSVALKLVVDREYAIERFVPVEFWNIRVHLKDPQTQKTFWAHLHSVNGKKWEKEIPEGKTSDEVILIDSKEKADEIVALLESATYVVDRVESKEKKRHAYPPFITSTLQQEASRHYRFSSSRTMNIAQTLYEGVDLDSQGAVGLITYMRTDSVRTDPEAVKQVRKYIEGHFGKEFVPSSPNVYATKKMAQDAHEAIRPTDVTITPESIRSKLTEDQYKLYSLIWKRFVASQMISAIYDTLAIRITTNKGIDLRATGSCLKFKGFLAVYEEKRDEEGDEEENIHLPKLNERDVLTKEELEAEQSHTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTLKEGQRLRPTELGKVVCQFLETNFPRIMDIGFTAGMEDELELIADNKKPWKQLLQEFCELFLPFVVTAEKEAFIPRIVTEIDCPKCHKGKLVKIWAKNRYFFGCSEYPTCDYKTSEEELTFDKNEYAEDTPWDAPCALCGGEMKVRHGKFGSFLGCENYPKCHYIVNLFKKGEAGAEPEATVHCPAEGCTGHLVKRRSRFNKMFYSCSEYPACSVIGNSVDAVIEKYAGTPKTPYEKKPKAKKSIASTKGKAAKTVKKSSATTKKRATKAYTPSAALAAVIGADPVGRPEATKKLWEYIKEKGLQSPQNKKIIIPDSKLQGVIGADPIDMFALSKKLSAHLIKEE
(273) DNA topoisomerase 1 [Lactobacillus helveticus DPC 4571]
1
MPTKAKSKSKTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDNYKPKYISIRGKGDTIKELKSEAKKAKEVYLASDPDREGEAIAWHIAHALNLDENAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWTIDAEFAKDKEKFKSAFYGVDGKKKELPNIDAVKDVLAKIDKKKNFTVEKVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRTSPVAQQEASKFLHENYGAEFAAKNQRHFKNQEDAQDAHEAIRPTSVYRTPESLKDVLTKEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVIFRTTGSKMKFAGFTKVYDNQQEKNVELPDLQEGDQVKMTKSDNKQHFTLPPARYTEASLVHALEKNGVGRPSTYVPTIDTIQRRYYVKLDGRSIVPTELGEIVDTLVEEFFPDIANVDYTAHLENELDEVEDGKKQWVNVVDEYYQPFKKELNKADSEIQKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKIGVVCPKCGKGEVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKHSKKGPVTLCPNGDYREEPQENEDK
(279) DNA topoisomerase 1 [Pelobacter carbinolicus DSM 2380]
1
MAQSLVIVESPAKAKTIEKFLGPGYKVLASYGHVRALPSKQGSVDVEHNFSPLYHVLPESQKHIELLKKEAKKSRELILATDPDREGEAIAWHLLEALGIDENAKSPEVKRVTFHEITKGAIQEAISKPGHIARELVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPARLYAVDGNSLGKFDINQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQEASRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVALSQVATGEARELITRMYGEDYALDKPRVFKNKAKNAQEAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLIWQRTVASQMATAQLEATTVDIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQEEGTLPPLEQEQPLDCQEVQPSQHFTQPPPRFTEASLVKTLEEHGIGRPSTYASIINTLTTRKYVRLEKRAFYTEDVGMVVNDLLVNHFNKYVDYDFTAQLEEDLDAISRGEREWQPVLKDFWEPFISRLKEKETQISKQDVTTEKTDRICPECGKPLVIKLGRSGRFLACSGFPDCRYTEPLAGQEREEPVMSDQTCEKCGAPMLIKQGRYGKFLACSAYPECKNIQPLVKPKALGITCPQCGEGELMEKKSRYGKIFYSCNRYPKCKYALWDLPIEEPCPKCKFPLVVEKTTKRQGTFRKCPQEDCDWTVVLIPPEPKAATKKTTTQKTAAKKTPAKKTAAKKTTAAKPAEKKTASKKSAAAKPAAKKTAAKKTTTTKAATQKAAPKKTAAKKATKKEE
(280) DNA topoisomerase 1 [Nitrobacter hamburgensis X14]
1
MFAPKPSAHLSRNRPRVFPLSYWNNMNIVIVESPAKAKTINKYLGASYEVLASFGHVRDLPAKNGSVDPDANFQMIWEVDPKAVGRLNDIAKSLKGADKLILATDPDREGEAISWHVLEVLKQKRALKDQKIERVVFNAITKQAVTDAMKNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCSREIEIEKFVPREYWSLIATLATPRGDTFEARLVGADGKKIQRLDIGSGAEAEDFRKAIEAANFIVSTVEAKPARRNPQAPFTTSTLQQEASRKLGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDGSAITQARKVIGEDYGNAYVPDAPRQYQTKAKNAQEAHEAIRPTDLSRRPADMKRRLDADQARLYELIWIRTIASQMESAELERTTVDIAARAGSRVLELRASGQVIKFDGFLALYQEGRDDEEDEDSRRLPAMSDGEALRRENLSVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLYGEDKGRVVVAFLENFFARYVEYDFTANLEEQLDRISNNEVSWQQVLKDFWNDFIGVVNEIKDVRVSEVLDVLDNMLGPHIYAPREDGGDPRQCPTCGTGKLNLKAGKFGAFVGCSNYPECRYTRPLAADGEAGGDRILGKDPESGLDVTVKSGRFGPYIQLGEPSDYGEGEKPKRAGIPKNTSPADMELDLAVKLLSLPREIGKHPETGEPITAGIGRFGPFVRHEKTYASLEAGDEVFDIGLNRAVTLIAEKIAKGPSRRFGADPGKPLGEHPTLGSVAVKSGRYGAYVTAGGVNATIPSDKTQDTITLPEAIALIDERAAKGGGKPKRAAKKAKSAGTERTGKAGAVAAKPAKKAAAKQASVKPKSAAVSKARGSIAAVKPPAKAEKAPAKKSAGKNG
(287) DNA topoisomerase 1 [Thermoanaerobacter sp. X514]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNSGKFEAKFYGTREDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYTNPEANYASKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFLASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVQEFYEDFYNTLKIAEEQMEEIDVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPNCDFILWDKPVDEKCPVCGSLLVEKNTKNGHILKCSNPECDYQKEVK
(289) DNA topoisomerase 1 [Treponema denticola ATCC 35405]
1
MENTMNETKKTKRTAKKTKQHCLVIVESPAKAKTIEKYLGGDYIVRASMGHLIDLPKSRLAIDIEHNFTPEYITVRGRAKILKELKKEAKKSSSVFLASDNDREGEAIAFHLHEALLPECSSPIKRIVFNEITPNAIQEAVKNPMDIDMGKVNAQKSRRVLDRLVGYNLSPLLWQKVKNGLSAGRVQSVALRLICEREEEVENFIPDEYWTLDGDFKYNKTSFEAQLVKYKDNKPELKNQKEVDAIIKELKSLPAVVDDIKITEKSIKPRPPFTTSTLQQVAANRIGFTSKKTMQVAQQLYEGVAVGSTRVGLITYMRTDSIRISDTAIEAVRKWINENHPKELPDGPNVYAAGKKAQDAHEAIRPTYIEYTPSYLKEFLTRDQLRLYSLIWERFVSSQMKNAKTKTSSYEIKVGDAVFRAASTKITEKGFYTVTKTLISKDEKGTSLPSMKVGDEISIESLRPEQHFTQGPARYTDASIVKMLEEKGIGRPSTYAPIISVLLERYYVTRSNKQLVPTQLGRIINNLLVKNFSEIIDVNFTAGMENRLDEVAENKIEWPKLMESFYGSFKEKVDTALENVESIKGSLDEVTDIVCEKCGNKMVKKLGRFGVFLACSAFPECKNTKSIPLAKCPREGCGGDIIARKSKKRGKEFYGCTHFPECDFISHFKPINASCPKCGWFMVEKYDKKNGNYKACINPNCDYLHSVVEGVEDVEVDRSNE
(295) DNA topoisomerase 1 [Bacillus weihenstephanensis KBAB4]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKYPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREKEIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNEAQVNEIIEKMKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARDYITEAFGAEYIGTEKRKETKKSKAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTAKLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDIEPKQHYTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVALDNKRFVPTELGGIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCSHPMVFKMGKYGKFMACSNFPECRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(300) DNA topoisomerase 1 [Rhodospirillum centenum SW]
1
MPGHNVVIVESPAKAKTINKYLGQDFTVLASYGHVRDLPPRDGSVRPDEDFEMDWELGDRSKRHIDEIARAVRGADRVYLATDPDREGEAIAWHMKEVLGERRLLGKVDVKRITFNEITKSAVQTALAQPRDVNRELVDAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLVCEREAEIEVFRPQEYWTIEADFRTQEGQTFTARLSQLDGKRLEKFTLGTQGDADAAVARIRPMTFRVGRIERKEVRRNPFPPFTTSTLQQEASRKLGFGATKTMRTAQRLYEGVDIGGETVGLITYMRTDGVALSQEAIDAARRLIDESWGRSYVPEKPRIYKAAAKNAQEAHEAIRPTDLFRRPEHVARYLEKDELALYELIWKRTLASQMASAVLDQVTVDIISKGAEAVFRATGSVIRFDGFLKVYQEDKDDADEDEDHRRLPPMRDGDDLARGEIRPNQHFTQPPPRYSEASLVKKLEELGIGRPSTYASILQVLQDREYVRLEKRRFIPEDRGRLVTAFLESFFPRYVEYTFTADLEGKLDDISGGRIDWKQVLREFWRQFSAAVEDTRDLTITQVLTALDELLGPHFFPRRLGPDGQEVDARVCPTCGTGRLSLKLGKSGGFIGCSNYPECRYTRPLSVAGEGGEAESGDRMLGNDPETSLPVWVKTGRFGAYVQLGNGDGKEEKPKRASLPRGMLPATMDLDTALRLLALPRSLGTHPESGLEIVAGIGRYGPYLKHGASYKNLTAEDDVLTIGLNRAVVVLGDAPAKKAVAGRELGAHPKDGKPVKVGSGRFGPYVQHNKLFASIPKSMSADTVTLAEALELLAAKAAKDGAKKGPAKAEGGEEAAATPAKKTTAKKAPAKKAPAKKTGAAKAESAGTDAEAETAEKPARRTAAKTTKAPAKASAAKASGTKAATRKAAAGD
(301) DNA topoisomerase 1 [Francisella tularensis subsp. tularensis SCHU S4]
1
MAKNLVIVESPAKTKTIKKYLGNEFEILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKAAKDAQNIYLATDPDREGEAISWHVQEVLKSARLLKDKNIYRVTFNEITKSAVTNAIANPKELSMDLVDAQKARQALDFLVGFNISPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLLEFNNNKVEQFTFTTAEDAENAKAHILKDANGFLIVDGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIQAKYDKDMLPAKPRVFEKKSQNAQEAHEAIRVTAANRTPESIKQFLTNDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHRFRVTGTVIVDAGFLKIYNVEKDEDEKDSDDEQTLPKFEKGEKIILNDVITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQREYVEVDKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLSVLNNFWHPFIERINKISEDVSRKDVVQEELEEDCPECGSKLSLRLGKNGRFIGCTNYPTCKYTRPVDSDPKEVIKEEPIVVEDRKCPKCNSDLHIKQGRYGKFIGCSNYPECKHMEPLEKPKDTGVVCPKCNKNHIVEKKSRKGKVFYACAGFPKCKNAYWYPPIKEECPKCHSPILLHKITKKDGEQKACPNSECDYAVAFETK
(302) DNA topoisomerase 1 [Candidatus Phytoplasma mali AT]
1
MKKLIIVESPAKAKTIYNYLNKEFLVLSSKGHVTNLSFTGKDGLGVDIENDFKPNYKVIADKKKIVQELIQSSKGKEVFLATDPDREGESIAWHLAKILNLDPTSKNRIIFREMTKNFIVDSVKNPQKINTMLVSSQETRRILDRIIGFKLSKLVKRFHSKSAGRVQSVALKLIVDLEINRNNFIPEEYYLIKVIFENFKVDLFINDSKKIKKEEVDEILKKIKGKSFMVKHIDKKTVYKNPSIAFITSTLQQTAFNELNMTSALTMMIAQRLYEGEIKIEGERTGLITYMRTDSTRMSLSFIENTQKFIKSNYGENYLGSYQQKKNVNSQDAHEAIRPTNINKTPESLKKYLKKDEYRIYSLIYYRTLSSLMKYAIFENTKVFFQSVDYTFILEGLVRKFDGYQKVLNIDNKDKILSNFSLKEVYYPKEFINEQCFTTPPTRFSEATLIKTLEKLNIGRPSTYSKIIKTLKDRFYVILENKRFVPNKQGILTKNILEKFFSDIINVKYTSQIEKQLDQIAIGKITQKNMLENFYCDFKNLYDIADKKITKIVPKITDQKCSLCNKFLSIKKGRYGEFLGCSGFPKCKNIVNLKKYYQK
(306) DNA topoisomerase 1 [Desulfobacterium autotrophicum HRM2]
1
MKKPLLIVESPTKVKTLKKYVGKDYNVTATVGHIRDLPPKELGIDIEDDFKPKYITIQGKTKVIQAMKSAAGDTDTVYLAPDPDREGEAIAFHAAEVLKKKGRTFYRVLFHELTQKGISEALENPLDLNHDRYEAQQTRRSLDRLVGYQISPLLWRRVQGGLSAGRVQSVAVRIICDRERIIRAFEPEEYWTITADLATDLPPTFTAALARIDNKKAVIPDQQTAEKIVGELENAAFVVEKIVSRTIKRNPLPPFITSKLQQDAINRLRFTAKKTMLVAQQLYEGIEIGTGGPEGLITYMRTDSIRIADEAAQEALEHIRQTFGPEYALATPRFFKNKNKAQDAHEAIRPTSVLNTPERLKSFLGEDQFKLYELIWNRFVASQMAQAIIDQNTISIQALNYTFTVGGTTVKFPGFMALYAAIDEKADKAKQKLPIIEQGMGLERKAIIPKQHFTKPPPRFSEASLVKELEENGIGRPSTYASILSIIRDKGYVELINRYFVPSELGFIVNDLLMTSFPEILDTDFTARMENDLDEIESGTKHSLGVLKAFYSTFKEKLDHAKENMLSVKGVGIPTGLSCPLCGKPLNIKMGRNGHFIACTGYPECSFSSNYTRDEKGAIQILETKTDNTKVKDCIKCGSPMVKKEGRFGEFLACTGYPECKHTESVNGDAGGRETGAKCPEPLCNGVIVEKRSRRGKTFFGCNKYPECTFASWDPVVNKPCPKCNSSYLIEKQTKKEGKFLKCPNKECTYKESLDD
(308) DNA topoisomerase 1 [Marivirga tractuosa DSM 4126]
1
MSKNLVIVESPAKAKTIEGYLGKDYKVLSSYGHVRDLPKGNNAIDIENGFKPTYEVSKDKKEVIKALIKEAKLAEMIYLATDDDREGEAISWHLKEALNLDDARTKRIVFREITKSAIQNAINSPKGIDIDLVNAQQARRILDRLVGFELSPILWKKIKTGLSAGRVQSVAVRIVVEREREIEKFKAESFFKIQAFFNVEGKELKAELPGRFKTEEEAMAFLEKCLDAEFSIGKLEKKPAKKTPAPPFTTSTLQQEASRKLGFSVSQTMTLAQRLYESGKISYMRTDSLNLSDEAKEGAAKEIKSEYGADYAHTRTFKTKSAGAQEAHEAIRPTNFATKEASSDYNEQRLYDLIWKRAIASQMSDAQIEKTNVSIDISNTDQTLSASGEVVKFEGFLKVYIESTDEEEEGETNVTKGMLPPLQVGQTLDLKRMQSREGFTRPPARYNEATLVKKLEEMGIGRPSTYAPTISTIQKRGYVNKEFRDGKDRKYVEMVLENGKINRSEKTEITGAEKNKLFPSNLAMVVNDFLVEHFPNVTDYNFTAKVEQEFDEIAKGEKIWNNMIKKFYGEFHQKVDDAESIERKDVNTGRELGVDPKTGKKVIVRLGKYGPLVQLGETPDSEDENAEKPKFASLRKGQFIESITLDDAMELFKLPRELGDYEDQKMVAAIGRFGPYIRHDGKFVSIPKGEDPLDITADRAIELIEEKRKADREKFIKSFDEDPDVQVLNGRWGPYIKFGKKNVKIPKDKEPAELTYQECVELAEKTPDKKGGRKAAPKKKATKKK
(309) DNA topoisomerase 1 [Pelobacter propionicus DSM 2379]
1
MPQNLVIVESPAKAKTIEKFLGKDYKVLASFGHVRALPSKQGSVDIEQDFTPKYHILPESKKHIDAIKAALKDAKNLLLATDPDREGEAISWHLLAALGLDKKNPGKSIQRVVFHEITKDAIIHAVENPRDIATDLVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFKEQEYWTIAARLGVKPGAEFRASLVEVGGKKLGKFDIPDENVATALNRALKSGSYRVAKITRTERKRNPSPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGIDIGQEGTVGLITYMRTDSVTLSSQALTEAHEVISAAYGAEYALAKPRIFKTKTKNAQEAHEAVRPTSIARTPAELKKHLTPDLFKLYELIWKRTVASQMAEALLDQTSVDIAAELNEAVADCTVAESGAASPFTGAKRCGLRAAGTVIRFPGFMKLYIEGLDDQDEEKEGLLPPLQEGDDLKLHELFPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYTRLDKKRFFPEDVGMVVNDLLVAHFSRYVDYNFTAGLEEELDQVSRGEKQWKPLLKEFWEPFITLLKQKEGEVKKDDLTTTELDEVCPECGKPLAIKLGKRGKFIACTGFKEGCTYTRNLESDASEPSEPVLSDEKCDKCGQQMLIKDGRYGKYLACSGYPACKNIQPLVKPRGTGVVCPECKEGELTEKKSRFGKLFYSCNRYPQCKFALWDPPVEQPCPKCGFPLLVKKVYKRKGEFLKCPKEGCDYTSE
(313) DNA topoisomerase 1 [Rickettsia akari str. Hartford]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKASKYVDAIVKDAKKADSVYLATDPDREGESISWHVAEVIKEKNKVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDKIERFKSEEYWDISIKIQSSNNELFTAQLTHVNDQKLEKFSIINAKDAKDLTEKLKSQKFHVDKIEKKQQKRAPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDTSYGNKYLPSSPRIYKSKVKNAQEAHEAIRPTNITYTPDNLKELLEKDYYKLYELIWKRTVACQMENVIMDLVVASLASENKEYLAKATGSTITFDGFYKIYRESVDDEDEEENKMLPPLKEQESLKTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFRKYVEYDFTAGLENELDEIAAGKLEWKAALNNFWSGFNNNIKSVNEQKITEIISYVQKALDYHLFGENKESKVCPSCKTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEAELSAIPNGNKILGTDKDGIEIYLKKGPYGPYIQHGEQEGKVKPKRSPIPAILNQNDITLEIALKLLSLPLKIGIHKDSGEEIMIGYGKFGPYIKYMSKFISIPKKYDFLNLSLDDAMKLIEDNNAKLETTQG
(314) DNA topoisomerase 1 [Caldicellulosiruptor kronotskyensis 2002]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAQEAEKVYLATDPDREGEAISWHLATILGLDTNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDVQEFKAKFYGDKKGKIELKNQDQVQKIEEKIKNKEFKVVKIKVSEKKKSPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRVSEEAQQAARSLIVQKFGKEYIPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFRLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGETLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVAKEDRFLKPTELGRIVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVKKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPVKNCPKCGSLMFEKGKKGNKKLVCSNENCAYQEKTGEKGE
(318) DNA topoisomerase 1 [Erythrobacter litoralis HTCC2594]
1
MQLVIVESPAKAKTIEKYLGKDFKVLASYGHVRDLPPKDGSVRPDEDFAMDWELYRDKQKRFKEISDAAKQADRLVLATDPDREGEAISWHVQELLAKRKALPAKVDRVTFNAITKSAVTEAMGRPRELDQPLIDAYLARRALDYLFGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDREREIEAFKPEEYWSVLARFEHDGTEFDARMVRFDGKKLDKMTLGNEGSALAAKAAVDAGRFTVSDIETKPLKRNPAPPFTTSTLQQEAARKLGFSASHTMRCAQSLYEAGAITYMRTDGVQMDGSAIAACRHAIEERYESAYLPEKPRFYATKAKNAQEAHEAIRPTNFNRDSAGSGDEAKLYGLIFKRAMASQMATAQLERTTITLEDPTGQHALRATGQVVKFPGFFAVYQEGFDDKSDEDEDGLLPAMHKGDAPAKKGVEANQHFTQPPPRFSEASLVKRLEELGIGRPSTYASTIQTLRDRDYVRMEKNRFFAEESGRLLTAFLERFFPNYVAYEFTAGMEEELDTVSDGREEYKELLAKFWADFKPKADEVMEKLPSEVTEVLDDYLSDYLFPPTEDGTEPRACPLCRDEGREGGRLALRGGRYGAFVACANYPECKYTRRFAQPGGNESAADDGIMGQHPETGEDIERKSGRFGPYVQMGEGKEAKRASIPKDLDDFDLDWAVKLLDLPRIVGAHPETGKEIEAAIGRYGPYLRHDGKYGKLQSTRDVFEVGMNAAVTILAEAANRKGGGRGKAEPIKTLGEHPTSGGEMKVMPGRYGPYVTDGTTNATIPKDMKPEDVSEAQAIELIDARAAKGPVKKKRKKAPAKKKAAPKKKAAAKK
(319) DNA topoisomerase 1 [Onion yellows phytoplasma OY-M]
1
MKSKVIIVESPAKTKTLSRFLNDEFLILSSKGHIRDLSLKGKDRMGIDIEKGFIPKYSIIKEKDNIVETLIQKTKGKEVLLATDPDREGEAIAWHLSQILNLDPQKTNRIVFREITKEAVLKALQQPRKIDELLVFSQETRRMLDRIIGFKLSRLVRRLKSQSAGRVQSVALKLIVDLEEKIKAFVPEEYYIITAFFKDFQAEYQNPYKGKTKAKEAFKIVQQITDKPFLVKELKQKEAKQSPKPPFITSTLQQEAINSLNITSNQVMRVAQKLYEGVDILGESIGLITYMRTDSQRLADSFVKDAQKLIKTQYGKEYLGTYKTNKKAQSQDAHEAIRPTDLSKTPESLAPHLDKYENKLYKLIYQRTLASLMTPAIFQKTQVFFEVANHLFLTEGLIKTFDGYQKILQDGTKDKIIPSFKLNETYLPQEIQNLQKFTNPPARFSESTLIKTLEKLNIGRPSTYSQIIFTLKKRIYVDLVEKRFVPTEQGILTAKNLELFFKQIIDVKYTAKMEENLDKISSGLVNNKELLQEFYDAFKQLYQIADQKLEKPKDIETDQKCNLCNAPLLIKKGRYGIFLGCSRFPECKNIVSLKEKSSSVETNPSMQTDQKCNLCNAPLLIKKGRYGNFLGCSRFPECKNIVKIKKT
(320) DNA topoisomerase 1 [Thermaerobacter marianensis DSM 12885]
1
MPKTLIIVESPAKAKTIKKFVGRDYTVEASMGHVRDLPKSQLGVDVDDHFTPHYITIRGKGKLIERLRQQARQADRVLLATDPDREGEAISWHLCQLLEIPQDSPCRIVFHEITRDAVRRALKEPRPIEENLVDAQQARRVLDRLVGYKLSPLLWRKVRRGLSAGRVQSVAVRLIVDREEEIEAFTPQEYWTLEADLQRRAGGEVFTARYHGDAEGKKDLPNRDAVDRLLADLEGRSFTVLGVERKERRRNPAPPFTTSTLQQEASRKLGFSVRRTMRIAQELYEGIELRGEGAVGLVTYIRTDSTRIADQALDEAAAYIAERFGPEFSAPRKQAGRRQAQAQDAHEAIRPTSVAREPDAIKDDLTPDQYKLYRLIWERFVASQMAPAILDTVTVEIGAGPHRFRATGSTVKFPGFMQLYVEGRDEGTEGEGDEGEGMLPELAEGDALDVRALRPEQHFTQPPPRYTEAMLVRALEEKGIGRPSTYAPIIETIQERGYVVKEDRRFRPTELGRVVTALLKEHFPDIVDVEFTARMEADLDRIEEGERNWEDVVRDFYGPFSETLSRAERQIQRVTLPVEETDEICEKCGRRMVIKHGRYGRFLACPGFPECRNTKPLVEKTGARCPRCGGEMVQRRSRKGRVFYGCSNYPECDFTTWDRPTAETCPECGTFLVEKRSRQGVRLVCANPQCNYEREAAGETAGAGAGSGRR
(321) DNA topoisomerase 1 [Methylocella silvestris BL2]
1
MYVVIVESPAKAKSINKYLGKGYEVYPSYGHVRDLPAKDGSVDPDADFAMLWDVDVKSAKRLNEIARAVKDADKIILATDPDREGEAISWHVLEVLKAKKVLKDKPVERVVFNAITKSAVLEAMQHPRQIDVALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEAFVAREYWSIVAHLRTQADAPFTARLVGADGKKITRLDVGTGAEAAAFKTDLENATFRVAEIEAKPAKRHPSAPFTTSTLQQEASRKLGFAPARTMQLAQRLYEGADIDGETVGLITYMRTDGVDLAPEAITSARSVIARQFGDAYVPKAPRKYTVKAKNAQEAHEAIRPTDLARLPRAVARALEPDQAKLYELIWTRTIASQMESAELERTTVDIEALAGARKLDLRATGQVVRFDGFLKLYQEGRDDEDDDESARLPDMAKDERLKRERIEADQHFTEPPPRFTEATLVKRMEELGIGRPSTYASTLAVLRERDYVRIEKKRLHPEDKGRLVTAFLEAFFARYVGYDFTADLEEKLDRVSNHEIDWKQVLRDFWLDFSGALAGTKDLRTTEVLDRLNEILGPHIFPPKEDGSDPRGCPSCGEGKLSLKLGKFGAFIGCSNYPECKFTRTLAAPDGAEANGGERPGVKSLGVDPDSGEEITLRDGRFGVYVQQGEGEKPKRSSLPPTIAPADLTLEQAIALLSLPREVARHPESKEPIVAGIGRYGPYVQHGKTYANVAKDEDIISIGANRAIDLIVAKESGLTGRRFGASESAPARVLGEHPAGGAVSVKAGRYGPYVTHGKINATLPKEADPTTLTLEGAVALLAAKASGGGAPMQGRLLGDHPSGGPITVRAGRFGAYVNHGKTNATLKRDASAETITLEEAIRLIEDKEAAGGGPRKAAAPKKAAKSSAAAKKAAPNAKNKTAPANDEDPPFEPSPNRKPAAKAAAAAHKKPAAKAAAAKLKQAKQA
(330) DNA topoisomerase 1 [Paracoccus denitrificans PD1222]
1
MPVVVVESPAKAKTINKYLGDDYTVLASFGHVRDLPPKDGSVDPEADFAMKWEVASESKKHVKAIRDALAADPNLILATDPDREGEAISWHLLETLAPALKKGAEVSRVTFNAITKAAVTEAMANPRQIDQPLVDAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVALRVIVDREMEIEAFKAREYWSVHARLATPRGDEYDATMTVFGGKKLERFDIASEEQAKLAVAAITSRDLRVASVAAKPASRNPWPPFMTSTLQQEASRKLGLGARACMSAAQRLYEAGHITYMRTDGIDMAPEAVMAARDAIKARFGAEYLPKSPRMYKNKAKNAQEAHECIRPTDMMLSPDRLPVSDKDQKALYDLIWKRTIASQMESARMERTTVEIGSADGQVGLRANGQVMLFDGFLRVYDQGRDDEEDEDSRRLPSIEEGERAEKRSVTPEQHFTQAPPRYTEATLVKRMEELGIGRPSTYASIVTTIQDRDYVRKEQNRLIPEDKGRLVTIFLLKYFPRYVSYDFTANLEGELDDISSGERAYREVLRRFWRDFTAALEGTSELRITEVLDAIDEALAPHLYPPRADGSDPRECPLCHKGRLHLKTARSGGAFIGCSNYPDCRFTRPISSPDAEVVGDAVLGVDNGDEISLKNGRFGPYVQRGEATAENPKPPRASIPKGWDLASVDLERALALLSLPREIGSHPEDGVPVEAGIGRYGPYVKHGAKYANLPDVDEVFTIGMNRAVEVLASKQVRGRAAVAAPLAELGEHPEGGSVQVMSGRYGPYVKWGKVNATLPRDLEPGAVTLERALELIAEKAAKSGKKPAKKAAAKKPAAKKPAAKKPAAAKAKKAG
(333) DNA topoisomerase 1 [Chlamydia muridarum str. Nigg]
1
MKKSLIIVESPAKIKTLRKLLGEGFIFDSSLGHIVDLPAKGFGIDIEKGFIPDYQILEGKEEVIRKICAEAKKCDVVYLAPDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEALKHPREIDMALVNAQQARRFLDRIVGYKISPILGRKLQRWSGVSAGRVQSVALKLVVDREYAIEQFVPVEFWNIRVNLQDPKSQKTFWAHLHSVNGKKWEKEIPEGKSSEDVVLIDSKEKADDLVSLLESATYCVDRVESKEKKRNAYPPFITSTLQQEASRHYRFSSSRTMNIAQTLYEGVDLDSQGAVGLITYMRTDSVRTDPEAIKQVRKYIENHFGKEYVPSSPNMYATKKMAQDAHEAIRPTDVSLSPESIRTKLTEDQYKLYSLIWKRFVASQMIAAIYDTLAIQIATNKGIDLRATGSCLKFKGFLAVYEEKRDEEGDEDENIQLPKLHERDELKKEEIEAEQSHTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTLKEGQRLRPTELGKVVCQFLETNFPRIMDIGFTAKMEDELELIADNKKPWKQLLQEFCELFLPFVVTAEKEAFIPRIVTEMDCPRCHKGKLVKIWSKNRYFFGCSEYPTCDYKTSEEELTFDKSEYADDTPWDAPCALCGGQMKVRHGKFGSFLGCENYPQCHYIVNLFKKGEAGSEPEEIVSCPAEGCTGHLVKRRSRFNKMFYSCSEYPACSVIGNSVDAVIEKYTGTPKTPYEKKIKAKKATASKKGKATKGKASTTKTKKKSTVTTKNRKTATYTPSSALAAVIGPDPIDGFPEATKKIWAYIKEQGLQSPNNKRVIVPDSKMKHVIGDDPIDMFALSKKIQAHLTKQE
(347) DNA topoisomerase 1 [Lactobacillus buchneri NRRL B-30929]
1
MATSTKTKPKAKAKSKTKRKSPKKNLVIVESPAKAKTIEKYLGRSYKVVASKGHVRDLPKSKMGVDIDHDYEPHYISIRGKGDTIKELRSAAKKAKKVYLAADPDREGESIAWHLQHILDLDPNEDNRVVFNEITKDAVKESFKHPRNIDMNLVDAQQARRILDRLVGYSISPLLWQKVKKGLSAGRVQSIALWLIIQREKAIKDFTPEEYWSIDSEFKKGRSKFKAAFYGLNGKKKELPNNEAVQKVLQQLDPKGDFDITKVTRRERKRQPQPPFTTSTMQQEANRKLNFRTRKTMMAAQQLYEGINIGKEGSQGLITYMRTDSTRISVIAKHEASQFLHEKYGAEYAATKPIKGKLPEGAQDAHEAIRPTSVFRTPASLKQYLTRDQFRLYQMVWSRFVASQMTPAIMDTMAVTIEQNNVTFKANGSKMKFDGFLKVYGDSKEKDNLLPDLESSDVVKLVKNNPDQHFTQPPARYSEATLIKALEEKGVGRPSTYSPTIDTIQRRYYVKEVGRRFEPTELGEIVNKIIVEYFPDVVNIDFTANLEGKLDQVEEGKENWIKLVDTFYKPFSDEVDAATKNMEKVQIKDEPAGINCEICGAPMVIKMGRYGKFYACSRFPDCRNTKAIVKEIGVICPKCHKGQVIERKSRKNRIFYGCSRYPDCDFVSWDKPIGRDCPKDGHFLVEKRVKGGTQVVCPNGDYEEPAQK
(357) DNA topoisomerase 1 [Acidobacterium sp. MP5ACTX9]
1
MSKSLVIVESPAKAKTINKYLGADYTVEASLGHIMDLPKSDIGVELLNRTFAPTLIVSPGKEKIVDRLKKLAAKADHIFLAPDPDREGEAIAAHLAMQLRPVIKAGADIRRVTFNEITQKAVKAAFLKARDVNENLVDAQQTRRVLDRLVGYQISPLLWDKVRRGLSAGRVQTVALRLIVEREREINAFVPVEYWTVDAVLQAEKTSFTARLTGIDGARITVPNGFDKDGKAQVLANALPDHATTDQVVADLANATFAVKTVEKKERKQNPKAPFTTSKLQQEAAGRLGFNVRRTMGVAQRLYEGIEIGGETVGLITYMRTDSTRVSDDAVAEARTYIGALGERYLPAKPNEYKKKNEAQDAHEAIRPTNVAYHPDEIRASLSDEQYKLYRLIWMRFVASQMMPAIFDQTTVEIGAKAARSYDFRVSGSVLKFDGFLKVYETAPAASTAEASDEDGEEEDKRLPALADGQGLVRQAIEHEQKFTDPPPRFNEASLVKTLEEKGIGRPSTYASIINTIQDRDYVKKIGNKFVPTEIGMVVTELLVKNFPYIFETGYTATLEGELDAVEAGTEKWTDLLDGFYSHLEKELAVAETTMEDIKRKEEATDEVCDNCGSPLILKWGKFGSFFACSAFSKAKAVTIAAAPWKKDPKAVLKKILGSFHFPMIVKAVTFDETNFSKEVADAKEFAEAVKSAAGKGKKITAEPVSCDFTKENFAAKPDLNAPGADEAPEEEFCDNCGRLMVLKNGPWGPFMSCPGYSDDPPCKTIRKLTQKVQSKPPITLDEPCPKCGKPLLQRDGAYGEFIACSGYPKCKYVKQELLDVKCPKDGGDLAVRKTKRGDVFYGCVNYPKCDFASNLKLVNETCPKCHSAYLLEYGNKEGTYLVCPNNREFLPKRRPKKGQPVEVPTTPECTYERLIGPPKTVEAEPEMAVSAA
(359) DNA topoisomerase 1 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]
1
MKKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKNPRKLNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDREKEIRAFVPLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSISDIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIAAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGRKILFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISILTSRDYVTIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIAEDKADWQETLKEFYYPFMRKIEEGKTKIASQKTVTKLGESCPDCGGELAIRKGRFGEFVACLNFPKCKYSRNLKSESKNESENTAAKAKANGTGITCPSCQKGEIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGETLVIKELKKGTFLECLKCKIKKEMKD
(360) DNA topoisomerase 1 [Thermotoga lettingae TMO]
1
MANKIIIVESPAKAKTIKEILKGEYDVLSSKGHVRDLPEKEFGVNIEKDFEPTFKIIYGKEKIVQELKKKAKNKQVLLGSDMDREGEAIAWHLADILGVANEKNRIIFNEITPQAIKNAVKEPRNIDMNKVHAQLARRILDRIVGYKISPLLWKMLKTSSSAGRVQSAALKIVCEREIQRHKFQPKKFWKVQGYIGSLKFYLTHIDGKKIDMQQIDEKLAKEIEKNVKVLKVIQIKTRKIQKKAPSPFITSTLQQEAANKLGFSVKKTMQIAQQLYEGIDTPKGHRAFITYMRTDSTRVSEIAKQKAIEFITDKFGKNYLGKKVRTEKAKQNVQDAHEAIRPVNIDLTPDQVEGDLGKDQYRLYKLIWERFMASQMADAIYEETTIQFQSDRYTFESKIERRIFDGFEIILKKDKEQEITIPSGEIRISKWQIEEDETKPPARYTEASMVRALEIRGIGRPSTYATIISTLLERKYVIKSSNQLIPTVMGFVVNHYLEKKFPEIVDLQFTAKMEEALDKIEQGQKDYKELLRDFYNDFSKYLDEAQQKWLSIDMNTNLECDCKSKYKLKVGRYGLYLLCENCSKTTSLALETPAVFYENTMYFTHQEKESIETVCPVCGGKLEQMSGRYGNYIKCQNCGKTYTGFARGKCPKCSAVVEKKISKNKRIFFKCTSDNCDFISWLEPSNETCPECSQRLYYKKYRSKEVLYCQNCKKTFQLKTKK
(361) DNA topoisomerase 1 [Lactobacillus crispatus ST1]
1
MPTKAKSKTTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDDYKPKYISIRGKGDTIKELKSEAKKAKDVYLASDPDREGEAIAWHVAHALNLDEKAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWSIDAEFAKGKETFKSAFYGVDGKKKELPNIDSVKDVLAKIDKKKDFVVDKVVARQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRTSPVAQQEASKFLHENYGAEFAAKSQRHFKNQEDAQDAHEAIRPTSVYRTPESLKSVLTTEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVIFRTTGSKLKFAGFTKVYDNQQEKNVDLPDLEEGDKVKMTKSDNKQHFTLPPARYTEASLVHALEENGVGRPSTYAPTIDTIQRRYYVKLDGRSIVPTELGEIVDGLIESFFPDITDVDYTARLENELDEVEDGKKDWVHVVDEYYQPFKKELNKADSEIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIIKEIGVVCPKCGKGQVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKHSKKGPVILCPNGDYREDSENEKNN
(367) DNA topoisomerase 1 [Campylobacter curvus 525.92]
1
MKDLIIVESPAKARTIKNFLSKNYDVIASKGHIRDLPKTSFGIKIEDDKFTPEYRVSLDHSKIVKEIKELAKGANEIYLATDEDREGEAIAFHIANAIGKEVSALPRIVFHEITKTAIDNALKHPRKIDMNSVNAQQARRLLDRIVGYKLSPLLNLKIQKGLSAGRVQSAALKIIVDREREIIAFKPVEYYSIDTKFKTDLDAELVKFEGKKIEKLTITNADRARYIVDALKNEKFSVREIESKDRKIQPSPPFMTSTLQQSASNRLGFSPKKTMMLAQTLYEGVQTHEGFMGAITYMRTDSLNLAKEAVEAARELIKNEFGKDYLPPKAVHYATSSKGAQEAHEAIRPTNLNFTPEIAAKFLQKDELRLYTLIYNRFLACQMSACVSQTQNLFVVSDNGEFKISGRKVLFDGFYRVYGDMDKDKILPNLNVGDEMKLESIKESQHFTEPPARYSEAGLVKKLESLGIGRPSTYAPTISLLTSREYVRVEKKQLIPNDVAFSMIGVLEEHFNDIVDSEFTSHLEEKLDLIAEDKADWQKVLSEFYYPFMDKISEGKTGIKSLKVATPIGEKCPQCGGELVKRKGRYGEFIACSNFPKCKYSRNIASQANDAGAQTTEPKAKKELVKLDVPCPKCGGVIVERFSRRGKFYGCANYPKCDFISNYEPTEHKCSECGSMMVKKELKKGTFLECTKCKHKVQIGEN
(368) DNA topoisomerase 1 [Desulfohalobium retbaense DSM 5692]
1
MSTDLIIVESPAKVKTIRKFLGSDYLVEASVGHVRDLPSSNLGVDEDNNFQPQYQIISGKQKVVSRLKSAAKKATTVYLAPDPDREGEAIAWHVAELLKKTNTNLKRIQFNEITSRAVKDALEHPRDLDERLFYSQQARRILDRLVGYKISPLLWKKVKRGLSAGRVQSVALRLIAERERERQQFDPQEYWVLKAHVQAAAPPPVVAELWKIGGKKPHVANETQALEIEKKVSEAGFHVESVEEKERKRHPKPPFITSTLQQDASNRLGFAAKRTMRIAQQLYEGLDLGDKGTTALITYMRTDSVRISNEARNAAQKWIVSTLGEAYYPEKPRYFKTKGSAQDAHEAIRPVDPTLTPGSIQSYLSREHFRLYKLIWERFMASQMAPARFWDTQLTLASANTLWRAKGERLIFDGYLRVYSADKSQEEVELPKVQAKDALTLEKIDKEQKFTQPPARFSEASLVRKLEELGIGRPSTYAQIISTLLDRNYVQLAKKQFVPTEMGFVVADLLTAHFPQLLDVGFTAEMEKKLDSVAEGDQDWTQLLREFTESFYPTLEKAEQEMQQVKTGVETGVSCPKCGKPVVIKFGRNGEFLACTAYPDCDFTSNFTRDEAGTIVIVEPEPQERQKVGTCPECGQDLVLKKARTGSRFIACTGYPKCKYTQSYSTGVKCPKQDCPGELVEKSSKRGKVFYACNQYPDCKTAYWNWPIAEECPTCGSPILVRKETKARGEHVACPEKGCGYWRELRDDEKH
(373) DNA topoisomerase 1 [Allochromatium vinosum DSM 180]
1
MNLVIVESPAKAKTIKKYLGPSFEVVASYGHVRDLVPKEGAVDPDHGFAMKYQIIERNEKHVQSIAKKLKDCEALYLATDPDREGEAISWHLHELLKSRRQLGDKPVHRVVFNEITKRAVQDAIANPRQISYDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREAEIEAFVQREYWTIEADTAKDARPFVARLTTFAGEKVEQFTITDEARATEVKTALEQAAGGKLKVEQVERKQRKRQPAPPFITSTLQQEAARKLGFTAQRTMRVAQQLYEGVDVGSGAVGLITYMRTDSVNLAQEAIDEIRAYVVERYSEADLPDAPRLFKTKAKNAQEAHEAIRPTSIRREPAAVKAHLTVEQFRLYELIWKRTLACQMAHALINQVAVDLSAGAGNMLRATGSMVVDPGFMRVYLEGRDDAKGADDDEDRMLPEMKVGELVDLLAIRPEQHFTEPPPRYSEATLVKALEEFGIGRPSTYASIISTLQDREYVILDKKRFVPTDVGRVVNRFLTDYFTSYVDYDFTARLEDDLDAVSRGEGDWVPLLERFWRPFKDLVDHTQEHVKRSDVTQERIEETCPKCGGQLAIRLGRNGRFIGCTQYPECDYTRDLDPDKAEREAPEVVEGRSCPLCGSALEIKRGRYGKFIGCSAYPNCKHIEPLDKPEDTGVTCPKCNKGTLQKKKSRRGKEFYSCSTYPKCDYALWDEPLAEPCPSCGWPVLTLKITKTQGAAKICPQKECGYRAPVEDQEAER
(375) DNA topoisomerase 1 [Arcobacter butzleri RM4018]
1
MASMGHVRDLPKSSLGFDPNDNFKPKYQISTDKKKVITDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAILKALENPRDVDQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFVPEEYWKIKADFINPELKAELAKENGKTLKISNEKQALEIEASLKQGSYKLVDIEEKESTRNPAAPFTTSTLQQEASRKLGFSVKQTMIIAQQLYEGNVGNIPNHTGGLITYMRTDSLNLSTVATTAAKAVIEEEYGKEYALNKPRVYTTKSKGAQEAHEAIRPVNLALRPSQIKEFVEPAQYRLYSLIWKRTLATQMAQAKIANTTYKIEAGKNKEFEFQVKGQRIIFAGFMKAYTEGSDNPEAALDSSEKILPNIKEGTILELEKLESEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYVSKTEDNKLIPTQTGEIVNSFLVDHFSNIVDLGFTAKIEEEFDEIAEGKIAWEEVMKNFYGGFKKTIDEKESSVSKEDYLQVNELGIDPKSGKPVSARVGRFGPFVQIGTKDDEEKPKFVAIPDNLNMDTITLEEALFLFNLPRVVGNTENGDEIKANIGRFGPYLQVKTKFYSLKTDDPYTIDLNRALEIIKDIDEAKEKSTIKTFDKEKIQILVGQYGPYIKQGRKNFKIPKGKNAEDLTLEECLEIIEKDSKGSTKRTTTKKSATEKKTTAKKTTKKSTDKK
(376) DNA topoisomerase 1 [Clostridium phytofermentans ISDg]
1
MPKYLVIVESPAKAKTIKKFLGNNYEVLASNGHVRDLPKSQMGIDVENGFEPKYITIRGKGDLLAKLRKEVKKADKVYLATDPDREGEAISWHLSQTLKLDDKSASRITFNEITKNAIKNSIKEARDIDMNLVDSQQARRMLDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREEEINDFVPKEYWNLDASFKVKGEKKSLVAKFYGDTKKKISIESKEEMDKILADLKGAQFKITEVKRGERQKKSPLPFTTSTLQQEAAKLLNFSTQKTMRIAQQLYEGVDVKGHGTIGLISYLRTDSIRVSEEADTAAREFIKTQYKPEYVNSQDVNKTTGKKIQDAHEAIRPTYVDLTPVIVKESLSREQFRLYQLIWKRFIASRMQPAKYETSTAKIDGNGYRFTVASSKLIFDGFMAVYASEDEEEENTTSNMMSLSEETQLTFEEFNSSQHFTQAPPHYTEAALVKTLEELGIGRPSTYAPTITTIIARRYVIKENKNLYVTELGEAVNRIMKQAFPTIVDVNFTVNLEALLDGVEDGVVNWKTVVSNFYPDLESAVQDAEKQLEQITIEDEKTDVICSECGRNMVIKYGPHGKFLACPGFPDCRNTKPYFEKIGVACPLCGSDIIIKKTKKGRRFYGCENNPECEFMSWQKPSGKLCPICNGIMVEKGQKLVCVNEGCGHVENKEQN
(379) DNA topoisomerase 1 [Weissella koreensis KACC 15510]
1
MPTTTKDKPKAKKRTTTKRKKNLVIVESPSKAKTIEKYLGSGYKVVASIGHIRDLPKSQMGVDTENDYNPKYINIRGKGDVIKNLKKEAKAAKHVYLASDPDREGESIAWHLAHILDLDTSSEENRVVFNEITKDAVKDAFKRPRQLDMNLVNAQQARRILDRLVGYSISPLLWKKIKKGLSAGRVQSGALGLIIDRENDIQAFQPEEYWELPAEFKKSNKKFKAGFYGLDGQKVKRIPDNEMVQSILKRIDQNQEFDISEVVKSEGKNNPSPAFTTSTLQQAANTQLSFQTRRTMSTAQQLYEGINLGGKEGSVGLITYMRTDSTRISSIAKNDASKFIHEEYGDEYAATKPVQGKLQEGAQDAHEAVRPTSVFRTPKSIKDKLTNDQFKLYQLIWSRFVASQMTAEVIDRVRVTLTQNGVMFRANGATTKFAGYTKAYPAAKAKDNVLPEMVEGGNVKLDKINPEQKFTQPKPRYTEAALVKALEEAGVGRPSTYAATIETLKSRAYVKMDAKKFIPTEIGKMVQDAVRDYFPDVADLKFTAQIEGELDNVETGNEDWVKVVDEFYKPFKGELDIAESEMEKIVVKDKLAGENCEICGAPMLERLGRYGKFFACSRFPDCRNTKTIVKEIGLVCPKCHQGQIIERKTKRGRTFYGCSRYPDCEFISWDKPTEKTLADGTTPKDGEDNKKSKTTKSKKPATKKATKKKAAKK
(384) DNA topoisomerase 1 [Truepera radiovictrix DSM 17093]
1
MGRTRAETGGRRLVIVESPTKAKTIRRFLPPSYRVEASMGHVRDLPASAAEIPAEYKNQPWARLGIEVERDFRPLYIVPSKKKRVVSELRAALKDADELLIATDEDREGESIGWHLLEVLKPKVPVRRMVFHEITEEAIRNALQNTRDIDRHLVDAQETRRVLDRLVGYTLSPLLWKKIAPKLSAGRVQSVAVRLMVLRERERILFVPASYWDLKASLAKADGAAQAFEAVMTHHGGVRLASGRDFDDATGELKAGLTPGKDVLLLSEARARELASRLRTAPWTVKEVETRDGKRTPAAPFTTSTLQQEASRKLGLSAKETMRVAQGLYENGYITYMRTDSTNLSREAIEGARRAVRTRYGAEYLSPAPRTYASKAKNAQEAHEAIRPAGSEMKTQAEHGLSGVEGRLYDLIWKRTVATQMADARLRFVTARITVGEGEDASEFRASGRTTLFPGFFRAYVEGSDDPEAALDDQEQPLPELARGDALRCRALEALGHETKPPARFTEASLVKLLESEGIGRPSTYASIIDTVISRGYARKNGAQLVPTFTAFATNNLLEARFAQLVDTGFTAQMEGVLDDIAAGEQEAGPYLERFYRGQEGLAARTQRSLGDVDAKAISTLSFPKWGEFVVRVGRFGPYAEGVIGGEVKTASLPAELAPDEVTRELLEKALVAGNADDNVIGTFPETHQPMLLKSGPYGPYLQLGDDDQEKPKRVSLPRGLEPSAVTYEQAVGLLSLPRTLGAHPETGEAVTAAIGRFGPYVKHQSTFASLPKDEDVLRVGLQRALELLAKKAARNRPLRVLGAHPETGDPVELHDGRYGLYVKHGKTNASLASGQSPDELTLEGALALLAEREGGARKAAKPKRAPAKAAKGAGKAAGKAPKGSKAPAKASKGRPKTKGATKASTKQLEAFLDTLSPTDAEVVARLEGMRGSAPQDLEAVADAVGLSEEAVRAAHKRGMFKLRMAFGRARKEAEPVAA
(386) DNA topoisomerase 1 [Xylella fastidiosa 9a5c]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPENGFAMRYDLIDKNEKHVEAITKAAKTADSIYLATDPDREGEAISWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRMIASDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFITREYWSIHAECAHPAQHFSAKLIKLDGQKFEQFTITDSDTAAAAQRRIQQVAQGRLHITDVTNKERKRRPAPPFITSTLQQEASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDIIARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVWKRAVASQMIPAILNTTSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPVMKTGENVPLERILTEQHFTQPPPRYTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVDMEGRSFRPTDIGRAVSKFLASHFTRYVDYDFTAHLEDELDAISRGEEEWIPLMKKFWVPFKELVEDKKDSLDKTDAGSVRLLGIDPTSGKEVSGRIGRFGPMVQIGTVDDEEKPRFASLRPNQSIYSISLEEAIELFKMPRVLGEDQSQQVSVGIGRFGPFAKRGSTYVSLKSEDDPYTIDLARATFLINEKEEIARNRIIKNFENSQIQVLNGRFGPYISDGKLNGKIPKDREPASLTLEEAQQLLIDTGKPARKNFSTKKTATKNETRKQTTKKRTTDAKATKKVSDKPVKKQIKKRIAPNITE
(387) DNA topoisomerase 1 [Fluviicola taffensis DSM 16823]
1
MSKNLVIVESPAKAKTIEGYLGKDFTVKSSFGHVRDLASKGLAIDVENNFAPEYEVSPDKKALVAELKKLAKESDVVWLATDEDREGEAISWHLYETLGLDKKDTKRITFNEITKGAILKAIENPRQINKPLVDAQQARRVLDRLVGFELSPVLWKKVRPSLSAGRVQSVAVRLIVEREKEIQQFNAESYFRVTGEFLKGKERIKAEVSKHFGTDTEVNSFLENCAKVDFEVLDVQQKPAKKTPASPFTTSTLQQEASLKLGFSVSRTMQVAQRLYEAGHITYMRTDSVNLSETAMEGAKNEIHSAYGKEYSHPMKYTNKNSNAQEAHEAIRPTNFGMHSLSRGEREEVRLYDLIWKRSIASQMSHAELERTTISIGNQKLAEVFQAKGEVIKFDGFLKVYLEANIDDEDNENETEGLLPAVRVGENLDRDFIRATQRFTRPSARYVEASLVKKLEELGIGRPSTYAPTISTIQKRGYVEKQEREGDERAYQVLELKGSAIDKQTKKEVTGKEKNKLFPTDIGMVVTDFLVDHFGGIMDYHFTAEVEEQFDEIARGKMEWTAMLTSFYKPFHHSVEDTLENSDRATGERDLGIDPASNKKVIARIGRFGPMIQIGDEKEDGEKPRFASLLGNQSIHTITLEDALELFQLPKNLGEYKGSPVEVNVGRFGPYVKFGDQFISLAKGDDPMGFTMDQAIILIDSKLQADAPIGTYEGLPVQKGVGRFGPFIKWNGIFINVSKKYDFDNLTQQDIDTLVAEKIQKDIDKVIYDWKEEGIRVEKARWGKTVILKGKLKIELPSSVEATTLTLDKVKEMIEKKTPAKKAPAKKAAAKKPAAKKK
(389) DNA topoisomerase 1 [Sinorhizobium meliloti AK83]
1
MNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLILATDPDREGEAISWHVLDLLRKKKVIGDKPVKRVVFNAITKKAVLDAMAEPRDIDASLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLPPKAIGNGEEANRLKSLLDGASYVVESVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIEAARQAIGSQFGERYLPEKPRFYSTKAKNAQEAHEAIRPTDFDRTPDQVRRFLDGDMLRLYDLVWKRGIASQMASAEIERTTAEIVADNAGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDEDGRLPEINARENLAKQKINASQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATVTTLIDRDYVEIDKRKLVPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLRDFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRICQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSNGDAEAAAANEPQSLGKDPHTGEEITLRNGRFGPYVQRGDGKEAKRASLPKGWTPAAIDHEKALALLSLPRDIGPHPESGKMISTGIGRYGPFVLHNGTYANLESVEDVFSIGLNRAISVLADKQSKGAGGGRASAAALKELGEHPDGGAITVRDGRFGPYVNWGKVNATLPRGKDPQSVTVEEALALIAEREAKGGVTKGKAAKGKPTGGKSAGTKSAKAASAGTAKAEKPKSAAKTKTKAAAKAKKD
(396) DNA topoisomerase 1 [Hyphomicrobium denitrificans ATCC 51888]
1
MNVVIVESAAKAKTINKYLGSGYKVIASYGHVRDLPAKDGSVEPDHDFAMQWEVDSKSQKIMREIADALKNADKLILATDPDREGEAISWHILEILNNKKALKKGTEVERVAFNAITKQSILAALKEPRKIDEPLVEAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIEAFKTDEYWTIEALLTTSRGDDVKTRLVAIEGTALKKLDIKDEASATAIKAALEGRDFRVASIEKKAAKRNPYPPFTTSTLQMDASRKLGFSAKQTMQIAQRLYEGVDIGGETVGLITYMRTDGVQIVPEAVSQIRDVISAEYGKQYTPFAREYKTKAKNAQEAHEAIRPTDPRRKPDQVRKYLEKDQAALYDLIWKRAIASQMAPADMEQTAVEIEAKGSDGKNYGLRANGSVLLFDGFLKVYEEGRDDRFRYIEKGKDDPEGEDEDRRLPALAEGDHLKDKEISADQHFTQPPPRFSEATLVKRMEELGIGRPSTYASTMAVLVDRDYVRIEKKRLVPEDKGRLVIAFLESFFKRYVEYDFTAELEEKLDLISNNELAYKEVLRDFWRQFIASVGEIKDLRVGDVLEALNEMLGPHVFPDKGDGSDPRLCPKCNQGRLSLKISGKYGAFIGCGNYPECNYTRQLSQSANNGEAALDGKVLGYNDDGIAVALRTGRFGPYIQLGEATGDEKPKRSSIPKGIDAATLDFEKAMQLLSLPRDVGVHPTEGGMITASLGRFGPFILHEHDGAKTYVNLGNVEDVFTIGINHAVTLLAEKRAGGGKSRFQRNAPKVLKDLGAHPSEGGPVQVLEGRYGPYVTHNKVNATVPRGKDPSALTMDEAVALIAERIANGGGKKSKASRSSAKPKAAKAAKPAKGEAAPAAKRTAKPAAAKKAAPAKKSAAKPAAKKLAKAKA
(398) DNA topoisomerase 1 [Syntrophobotulus glycolicus DSM 8271]
1
MPKTLVIVESPAKAKSISKFLSKNYQVKASMGHLRDLPKSQMGVNIEHDFEPKYIPIRGRGDLIKELKAAAKTADQVLLASDPDREGEAIAWHLMHLLGINQEKSSRVEFHEITKPTIQKAIKNPRKIDLHKVDAQQARRVLDRLVGYKLSPLLWKKIKKGLSAGRVQSVAVRLICDREEEIKVFESQEYWTLLAQFLCPGGNFSAKLIHKAGKRIEIKSRQEVDEIIVQLRRAVCVISDVKNREKKKQPSPPFTTSSLQQEAYRKLNFAPKRTMMLAQQLYEGIDLGKEGTVGLITYMRTDSVRISELAQDEAKEYILASFGSDFYPGRQNYTSKRRTQEAHEAIRPTSVLRTPDSAKEFLSRDQLRLYRLIWDRFLASQMSAAVYDTLTVDVAADKYTLRANASTVKFPGYLSVYEESTDETEEKQDGDDRCLKVNVTPGQKVELAEIKEKQHFTEPPPRYTEASLVKKMEEEGIGRPSTYAPTIDTVQTRGYVVKEERKLVPTELGEIVVSLLKEHFKDIVDLEFTANMEEKLDNIEEGQTQWKSVIRDFYIPFEETLNKAEAIIGKIKVEDQESDVLCEFCGRRMVIKMGRFGKFLACPGFPDCKNAKPLLEEVGVNCPQCGEKLVVRRSKKGRKFYGCSNYPECNFISWEKPAPVNCPDCNSLMTEKTIKQKVNYVCTNKDCRHTEEKVEEKKE
(399) DNA topoisomerase 1 [Chlamydophila abortus S26/3]
1
MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKEFGIDIEQDFEPDYQILPDKQEVISQIRKLASSCDIVYLSPDPDREGEAIAWHIANQLPKHTRIQRISFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIRVFLQDPKTSTTFWAHLYSAEGKKWEKELPKGKTEDEILLIQSEAQAQHYVALLEDAAYRVTRVEVKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALSNVRDYIHNTFGQEYLPKSPNVYTTKKMTQDAHEAIRPTDIHLSPDKLEGKLSDDQLKLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKLDDDTTEEENLSLPQLHAQDVLDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTAAEKEAVIPRVLTDITCSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVDTPWNSPCPVCGGDMKVRHGRFGTFLGCLNYPQCRGTISIHKKGEEVEKEETLPCPAVGCSGKILKKRSRYNKTFYSCSEYPDCSVIGNTIDAVITKYTGTPKTPYEKKTTGKKKATTKSSSKTTKTTTKKKKSEGKTPKTPKAGALLTPSPQLALMIGPEPLGRGEATKKVWQYIKDHNLQSPENKKMLLPDDKFAAIIGPEPVDMFQLPKLLNQHLFKSDVSPGSSSASS
(404) DNA topoisomerase 1 [Marinithermus hydrothermalis DSM 14884]
1
MPGKTLVVVESPAKAKTIARILGDGYEVKASKGHVADLPERTLGVDLEADFAPTYEIKKDKRPVVEALRKAARGAERVILATDPDREGEAISWHVARLLDLDPSAPVRVHFHEITPRVVREAIAHPAPINQNLVDAQQARRVLDRLVGYNLSPLLSEKFRQRALSAGRVQSVALRLIVEREEEIEAFEPQEYWTVSGAFTAGAPFTAELYSIDGQRVVDKNRSRFLLTSEAETARILEAIRRVPEWRVAEVARKTRRKSPPPPFTTSTLQQAASSRLGWTASRTMRVAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEALEAVRRFIPEAFGPAYLPQTPNRFKSKKSGVQDAHEAIRPTAVERTPERVKPHLSEEEYRLYTLIWQRFVASQMSPAVYDQTVVTVEGGAYRFRATGSVLRFDGYLRAWGREEDEAEQLLPEIPEGAPAQLTDLTPAQHFTQPPPRYNDASLVKTMEELGIGRPSTYAPTIETLERRRYIERQGRALRPTPLGREVVAFLKAHFPRVVAYEFTAEMENRLDAVEEGKVPWPKVVREFFEPFTKELEKVPRKTCPLCGRPLELKVSRYGQFLGCTGYPECRYTEPLEKREAEPLGEPCPECGRELVRKHGRYGTFIACSGYPECTYTRDEAPSTGLTCPKCREGEVVVKTSRKGKPYYRCNRKACDFLSFYPLVEERCDTCGWNLMEKGRAKTRVCSNPACPRYGGPDLSKPRPSRKSRATRRAAKPKPAPAPKATWTDLEPFLSRLAEDEARLARLVEGEGRSLKDAAQALGLTEEAAAALYKRAIFKLRMAYGRARKAGEGSVPEEVT
(409) DNA topoisomerase 1 [Sulfurovum sp. NBC37-1]
1
MKNLIIVESPAKARTITSFLGKDYKVIASKGHIRDLPKSTFGITIDDETGDLIPKYSIPRDANPTVKELKKLAKEAETIYIATDEDREGEAIGYHIAKAIGKEPTELPRIVFHEITKSAIQHALENPRKVDMDSVDAQQTRRLLDRIVGYKLSPLLASKIQKGLSAGRVQSSTLKIVVDREREIKAFKPEEYWTIDALFEKNIDASIYDYNGLKIDKLTIKTDADANEIVESAKGESFVVSSIEKTKRKTKTPPPFMTSTLQQAASTQLGFSPKKTMMVAQKLYEGVKTDKGTMGIITYMRTDSLNLAKEAVEAARTHIKETYGDKYLPAKAKHYTSKSKGAQEAHEAIRPTRVDFDGTKAANFLNADELKLYRLIYNRFLACQMTEAELESQTILFKGDKCTFKASGRKLLFDGFYRVTGYNEKDKLLPELKKEQPVSLDDIKAEQHFTEPPARYNEASLIKKLESLGIGRPSTYAPTITILQTRKYIEIEKKRIHPTEIAFTVIEMLEKHFPEIVDSGFTANMEETLDKVAEGETDWQTILKEFYTPFLQKIEEGKKNIKSLKVAIPTGENCPKCGSELLLRKGRYGEFIACSNFPKCKYTKNTDGTEVEQPEETDEKCEKCGSPMVIKNSKRGKFLACSAYPKCKNAKSLTPPKELSVPCPECGGKLQEREGRRGKFFGCENYPKCKFIANFEPVDKKCPECGYTMGKKTLRGKEIFECFKCKHKEEAK
(419) DNA topoisomerase 1 [Brevundimonas subvibrioides ATCC 15264]
1
MNLVIVESPAKAKTINKYLGSGFEVLASYGHIRDLPSKDGSVKPDEDFAMEWEVDARASTRMTEIAAAAKRADRVILATDPDREGEAISWHVLEVLNKKKAIKDTPVERVTFNAITKSAVLEAMANPRQIDMELVEAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIVVDRELEIERFRPQEYWSIEADLAADSPPFTTRLVKHAGKRIQRLDIKDEATANAARDAIQTGDFTIRSIEKKPVRRFPSPPFTTSTLQQEASRKLGFDAQRTMRAAQKLYEGVDETGGLITYMRTDGVQTTPEGIAQAREVIGETFGPAFVPAEARYYKTKAKNAQEAHEAIRPTNIARRPDSLRLESDLQRLYELIWKRMVASQMEAARLDRTTVEVETPDGQTGLRATGQVVTFDGFLAVYEEGRDEKQKGAESEEDDDTARLPTLKEGAKAKVEAIRTDQHFTEPPPRYSEATLVKKLEELGIGRPSTYASILTTLRDREYVRMDKNRFIPEDNGRLVTAFLEQFFGRWVEYDFTAALENQLDEVSAGDMDWKALLREFWSKLKPATAAVLERQGVIDELDTAIGPFLFPEKADGSDARLCPLCKTGHLHLKASFKMKSSFIGCSNYPECRYTRGFGAGENAGDEAGGDRELGIDEATGLPVALKIGRFGPYVETANPGEEKPKRSSLPKGWSPATLTLEQAVRLLALPRPVGDHPEDGKPITAGLGRYGPFILHAGTYANVADIDEVFDIGLNRAVVLLAEKRAGKFAGRGAAVAPLKDLGAHPESGEPVHVMAGRFGPYVKSGKINATLPKGTAPEDMTMEIAVPLLAARALVAPKAKKAPAKKAAPKTAAAKKPAAAKKPAAKKPAAKKTKTVA
(420) DNA topoisomerase 1 [Syntrophothermus lipocalidus DSM 12680]
1
MLVIVESAAKAKTISKFLGRNYKVLASVGHVRDLPKSKLGVDVEHGFTPQYVTIRGKGEILKHIREESEKSSRVLLATDPDREGEAIAWHLSQAMNLKDKNPCRIEFNEITKDAVTRAVKKPRPIDMNRVNAQQARRVLDRLVGYSLSPLLWNKIKKGLSAGRVQSVALRLICEREREIESFVPEEYWTIEGEFAAGNKALVARLVARGREKLEIGSREAVDAILAELETARFTVSKVEKKTKKKNPVPPFITSTLQQEAYKKLGFTASRTMRVAQELYEGLSLGEGGTVGLVTYIRTDSSRVAEEAQKEALDFVEQTFGKEYRPEKPNVYKSKKTAQDAHEAIRPTSVWRQPERVKTFLTRDQYRLYKLIWERFLASQMAPAVYDTVTVEITGGGYVFRASASNLKFPGYLAVYQESENEEEDEKRAIPEVQEGQELVARGFKPEQHFTQPPPRYTEASLVKMLEEKNIGRPSTYAPIVDTILRRGYVERKNKQFVPTELGFIVVDLLKDYFPEIMDVEFTASMEENLDRIEEGELNWQETVEEFYVPFSDKLRKASSEIEKVELKPEEAGKDCPVCGKPMVIRNGRYGRFLACSGFPKCRYTESVNEETGITCPQCGRKVIALRTKKGRRFYGCEGYPQCDFRSWNLPTEKKCPQCGGPMVRKRGRGQEYLACTSKECRYEEKEARM
(421) DNA topoisomerase 1 [Sphaerochaeta coccoides DSM 17374]
1
MDSQKNEKVLIIVESPTKARTIKKFLPGNYTVVASNGHVRDLPSDRLGIDVKKGFKAEYEVVSGKGTLIKTLKADLKSVDRLLLATDEDREGESISWHLLELLKPSIPYQRMVFHEITKRAILNSLDTGRKLDMYLVHAQEARRKLDRLFGFELSPVLWKKLSNKKLSAGRVQSPGLRLIVERERERIQFVSSTYWDAKATLYSASPAFTAKLEALEGRRVAGSKDFNPTTGAFLKEGKADAPILLDADTARDVTEKLRSAEWTVAEVVEKPVTSRPAPPFITSTLQQEGNRKLHLSAKQTMTIAQKLYENGFITYMRTDSPSLSQDGIEAARKSVDELYGNAFLSDAPRQYAAKSASAQEAHEAIRPAGDVFIKPDESGLHGKDKALYEMIWKRTLASQMAEARKSLTSVRINAQADGVSARFVATGTQILFPGFIRVYVEGSDDPEAALEDKESFLPVLKEGQKLDLETLEAVSHETKAPARFTEASLVQQLEKMGIGRPSTYATIIDKLFDRSYVQKDGSALVPTFVGFSVVQLLEKHFDRYVDYSFTSGMEEDLDGIAAGKIDEIDFLTRFASGPQGLEAIVAEKMQEIVAPDAKKIDLPQLTGEPDIFIGPYGPYIISQSDDNGNVYVSLPRAWIPADVTKEMLEELLEKDWKIRKDGNDGGIGTDPRTGKTVFLISGRNGDFWQLGERVEGSKERPRTSSVPKGEDGQSLETALRYLALPRELGSDPATSVPVSAGIGKFGPYVTRGGEFRSLRGGETSVFTVTLEEALALLAQPKSAGRRAGSGRGGKIGGADKTLVLSFGDYKGEALAIHVGRYGYYLKHGKKNYQLPEASMKKDEAAAKTLTEDQARAIVDTKA
(426) DNA topoisomerase 1 [Desulfatibacillum alkenivorans AK-01]
1
MSKPLVIVESPTKVRTVKKYLGNDYNVAATVGHVRDLPQKNIGIDIDNNFEPQYEVIPGKQKVISNLKKLAKDASEIYLAPDPDREGEAIAWHTAQLLQGKNRRFHRVLFHELTKNAILNSMQNPLELDKSKFEAQQIRRILDRLVGYQVSPLLWKKVQRGLSAGRVQTVAVRMICEREREIQAFDPEEYWSITAHLQKDEPPVFPAKLLKIGDKKAKVSNEEEANAVLKELEGETYVVDRVIKKTVKRNPLPPFTTSKLQQDSIHKLRFSAKKTMLLAQQLYEGIDLGPGEPVGLITYMRTDSTRVSNEAALEALDYIGKVYGPEYRPDKPRFFQNKKKVQDAHEAIRPTNVLRTPNQVSDVLSKDQLALYTLIWQRFVASQMNPALFDQTSVSVKAGRYLFHATGSTLKFKGYLMVYDAGDGDKDDNKIMLPVLEEKMILQCNKLEPKQHFTQPPPRFSEASLVKELEENGIGRPSTYAAILSTIRDKGYVDLVKRYFRPSELGFIVNDLLVSSFGDIFEVPFTAQMEDNLDKVETSQANSLEILNAFYNSFKQDLENAGDKMVSVKGVGVPTGIKCPQCEKELHIKIGKNGPFLACSGYPECRFTRNYDRDDKGGIVMETPPETEETDEVCDKCGKPMLVKSGPYGTFLGCSGYPDCKNTKTMNGGAQQNQATGIKCPVEGCDGEIHERRSKRGKVFYGCSKYPKCDFATWDKPVDKPCPVCQSPYLVEKSTKKSGVYLKCPTRGCKYREDPQ
(427) DNA topoisomerase 1 [Bacteroides thetaiotaomicron VPI-5482]
1
MQKNLVIVESPAKAKTIEKFLGKDFKVLSSYGHIRDLKKKEFSIDVDKNFKPDYEIPADKKALVSTLKAEAKEAETVWLASDEDREGEAIAWHLYEVLKLKPENTKRIVFHEITKGAILKAIEQPRNIDLNLVNAQQARRILDRIVGFELSPVLWRKVKPSLSAGRVQSVAVRLIVEREREIHAFKSEAAYRVIAIFLVPDTDGKLVEMKAELSRRIKTKEEAKAFLDACKGATFTIEDITTRPVKKTPPAPFTTSTLQQEAARKLGYTVAQTMMIAQRLYESGFITYMRTDSVNLSEYATASSKDAIIQMMGERYVHPRHFETKTKGAQEAHEAIRPTYMENQSIEGTAQEKKLYDLIWKRTIASQMADAELEKTTATISISKSGDAFTAIGEVIKFDGFLRVYRESYDDENEQEDESRLLPPLKKGQKLEYGPIVATERFTQRPPRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVEKGNKDGEERTFNVLTLKDNQIKDESHNEVTGAEKSKLFPTDTGTVVNDFLTEYFPDILDYNFTASVEKEFDEIAEGEVKWTSIMKTFYDQFHPAVEKTLSIKTEHKVGERMLGEEPETGKPVSVKIGRFGPVVQIGAADDEEKPRFAQMKKGQSMETITLEEALELFKLPRTLGEYEGKTVTVGIGRFGPYIQHNKVYVSLPKTLDPMKVTLEEAEQLILEKRTKEAERHIKKFDEEPELEILNGRYGPYIAYKGNNYKIPKDIVPQDLSLKSCFDLIKIQDEKGPGTSAKGKRTAKKK
(429) DNA topoisomerase 1 [Thiobacillus denitrificans ATCC 25259]
1
MSKLVIVESPSKSKSLKKYLGADYDILASYGHVRDLEPRTGAVDTENFSMKYQIIERNAKHVDAIVKAAKKADEVLLATDPDREGEAISWHISEILKEKKVKTPMKRVAFYEITESAIQDAVRNPREIASDLVDAQQARRALDYLVGFNLSPLLWKKISPGLSAGRVQSPALRMIVEREEEIEAFVAREYWTLHLDSHKGSQAFTAKLTHFKGEKLDQFAVEHEARSKEWLATLESKDARVMRIEKKRRARNPAAPFTTSTLQQAGVRQLGMTTDRVMRTAQQLYEGIDLGEGPVGLITYMRTDSVNLAQEAITDIRKYVGANFDKDYLPPHAVQYKAKTKNAQEAHEAVRPTSVLRTPDAVRQFLTQDQARLYELVWKRTVACQMTAAQFDTVAADITVGEGTFRATGQTLAFAGFLAVYQDDEDDEGESKLPALVEGETLPVDRLYGEQHFTQPPPRYTEASLVKALEEYGIGRPSTYASIISTLQDREYVVLEKKRFQPTDVGRLVNCFLTRHFSHYVDYDFTAKLEDKLDDVSNGKRVWSRLLGEFWSGFEGDLKAKQDVERGCPILEACPKCAKPLFMQASKRGLFIGCSGYPECDYTRPLHPATAEGDNILGKDPASGLDVKLLSGRFGPYVQIGDMPEDKKAPKPRRASWPKDIPLENATLDLALKFLSLPREVGHHPTTGLPIVANNGRFGPYLLHDGKFKSIPKTDSVYEIDLPRALEVLAMERAPRGADSAASVLKNLGPHPEDGKDITVRSGRYGPYVKHGSTNATLPKDITPEAVTLDEAIGLIAARVAKGPAKKPPRKAPTKASATKTKAADTATKPAATKKAATKKAPAKPAATKKPASKKAA
(430) DNA topoisomerase 1 [Denitrovibrio acetiphilus DSM 12809]
1
MPKNLVIVESPAKARTIEKYLGRNFKVLASVGHVKDLPASSLGVDLDNDFEPKYSIIRGKKKIIDELKKVANSAENIYLAPDPDREGEAIAWHIAEELGKKNKGKIYRVLFNEITKKGIEDGIKNTGPINENRTNAQQARRILDRLVGYLVSPLLWKSLKYGLSAGRVQSVALRLLVEREEEIEKFKPEEYWLIDVTFKGGQKALLKARLEKKNGKKYRVPNGEEAEAVLAALKAGSYNVNEVIRKEVFERAPLPFITSKLQQEAARKLSFSAKRTMMLAQRLYEGIELGSEGPVGLITYMRTDSTRVSPDATNEARGYIEKQYGKEFLSKGVKGGSKKKNVQDAHEAIRPTSVAITPESVKKILDTDQYKLYKLIWDRFVSSNMADAVYDQNTIHIANGPYLLKSQGKVMKFPGFQTLYIEGVDESKEKDQEVIFDVKEGETLNPEKHDSKQMFTQPPARYSEATLVKTLEAEGIGRPSTYASIISTLIDREYANMEEKRFKPTELGRVVCSLLIANFDRIFEPKFTAGMEEDLDSVEAGELTWKGVLRDFYAKFKPELEKAEKQFSANLKIEMKCPVCEKDLTIKYGRNGNFVACTSYPECKFTSNYERLEDGSFKLVPKEEDKPSGIECEKCGKELVFKKTRFGEVLACPGYPECKNIKNYVTLPDGEIKILAAGEEIGTPCPKCEAGLTIKGGRNGMFIGCKNYPDCDFTANMEVNEQGDIIPKYDKVDENVKCEKCGKPMVLKKSRRGKFFACTGYPECKNAKSTIVLEDGTISVKE
(434) DNA topoisomerase 1 [Melissococcus plutonius DAT561]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENDYAPHYISIRGKGDVIKSLKTAAKKADKVYLAADPDREGEAIAWHLSYLLGLDPNEKNRVVFNEITKEAVKAAFKEPRTINLDLVNAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKIIIDREKEIKEFIPEEYWTIDGNFQKGRKKFKASFWGIEGKKKKLPKADSVKEITDKLKDDKYQVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMIAQQLYEGISLGKKQGTVGLITYMRTDSTRIAASAKVEATEYIEQTYGKEFSIQEERKVKKAQGTQDAHEAVRPSSVLRTPDSIKEYLNKDQLKLYTLIWSRFLASQMAPALLDTMKVTLEQNQVMFIANGSKIKFKGFMQVYIEGRDDGKEEKENILPELVEGDSVTSINIEPKQHFTQPPARFSEATLIHNLEENGVGRPSTYAPTLETIQKRYYVKLTNKRFEPTELGEIINTLIVDFFPQIVDVHFTAAMEEDLDKIGDGKEEWITVVDRFYQPFEKELTNAEEKIEKIQIKDEPAGFSCEECDHPMVIKLGKYGKFYACSNFPDCRNTKPIVKEIGVRCPICHEGQVIERKSKKNKLFYGCSRYPDCDFTSWDKPVGRLCPKCGKYLVEKKVKGGKQVVCINGDYEENVQK
(436) DNA topoisomerase 1 [Ruminococcus albus 7 = DSM 20455]
1
MSDLVIVESPHKAKTVKRYLSGDYEVVASMGHLRDLPKSKLGVDIENDFEPQYINIKDKESLIKEIKKKAKASDHVYLAGDPDREGEAISWHLAQLLGLDMNDKNRVTFNEITKSGIDAGMSNPRTIDLNLVNAQQARRILDRIVGYKLSPFLWRKIRRGLSAGRVQSVAVKMICDRENEIRAFVSQEYWSIDAMFLAEGSKKAFASKVDTVDGAKPDLKSKADADAVLKRLEGAEFIVDKVKKSVRKKNPAAPFTTSTLQQEASRRLGFQGRRTMKAAQELYEGLDIKDMGPTGLITYMRTDSLRISDEARAAAYDFIKEKYGDAYIPEKPRVYKTKGSAQDAHEAIRPTNPAITPELVKASGVTNDQYKLYKLIWERFIASQMANCTMDTMSVDIAANGVMFKATGYSVKFDGFTVLYEESKDEEEEKKNVLPPLAKGDKLTPKEILGNQHFTQPPPRYTEATLVKAFEETGIGRPSTYVTTVTTIINRNYVERDGKQLKPTSLGEVTNELMSEHFDKIVDVKFTANMEKSLDDIESGKIGWVKTLQKFYKEFDSELGTAEKEMEGKRVKVPDEATDEICEVCGKPMVIKIGRFGKFMACSGFPDCKNTKRIVQETGGDCPFCGKRVLLKKSKKGKKYYGCENNPECSFMTWDIPTEEKCPRCGSTLFQKGGKNGILICHKQDCGYQRSLSGESAGSEE
(439) DNA topoisomerase 1 [Capnocytophaga canimorsus Cc5]
1
MAKNVVIVESPAKAKTIEKFLGKDYKVVSSYGHIADLPAREIGVDIDNGFTPKYIVSSDKKELVKELKKLTTEAETIWLASDEDREGEAIAWHLAETLNLKSENTKRIVFNSITKSAIEKAIQNPRGIDYNLVNAQQARRILDRLVGYELSPVLWKKVKSGLSAGRVQSVAVRLIVEREREIQDFKTQSSYKITAEFTNAEGKTIKATLAKGFDSYDDAQRFLQKNIGANFTVATLEKKPAKKSPAPPFTTSTLQQEASRKLNFSVSRTMTVAQRLYESGLITYMRTDSVNLSQEALQSAKNAIKGIYGEKYAHSRNFSSKTKGAQEAHEAIRPTDMSRPSITIERDQDRLYELIWKRTIASQMSDAQLERTSIKIAADKHDEMFTANGEVILFDGFLKVYLESTDEEDEEQEGMLPALTQGEKLNNNFITATQRYTRPPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVERSAFEGEQRNYQTLTLSEGEIQEKILSENVGADKGKMIPTDIGIVVNDFLVSHFESIMDYHFTANVEESFDHIAEGEEDWRKMLESFYNQFHPVVQDVEQNASRETGTRVLGIDPKSGRPLSVRLGRFGAMAQIGTNEDDEKPVFASLLSGMSIETITFEEALKLFELPRKLGIIDGNEVEVNVGRFGAYVRYGNNFASLDKGEDVFSVTLDRAREIIALKQKADAPIATYQGLEVTKGKGRFGPFIKWNDMFINVSKKYDFDQLSDTDIEELIETKLQKESEKVVKEWNNGEIRLEKARWGRFNLIKGKTKIELPKDTDTQNFTLEQATALLDTKTKKAPAKKTTATKKTTVKKSTTKAKKV
(440) DNA topoisomerase 1 [Clostridium lentocellum DSM 5427]
1
MADNLVIVESAAKVNTISRFLGKNYKVEASIGHVRDLPKSQLGVDTANNYEPKYITIRGKGELLQKLRKDVKNAKCVYLATDPDREGEAISWHLYHALKLQEKKVCRITFNEITEQAVKEAIKHPRDINTDLVDAQQARRVLDRLVGYEISPILWKKVRKGLSAGRVQSVTLRLISDRDKQIREFVEEEYWSITANLQQGKGKTFEAKLDTYKNEKCDINNEEEAKKIVKACKKGHFQVVSSKKGTRVKNTVLPFTTSTLQQEAAKHLGFSTQKTMNIAQQLYEGIKVGKKEVGVVTYIRTDSIRIADKAKEEATTYITQKYGEQYLGAKKQIEKAKKAHIQDAHEAIRPTYMEYEPNEIKEYLSRDQFRLYQLIWNRFVASQMAPAQYETYSIKVQNGDYEFKASYSIELFDGFIKVYNLGEEKAKKEAKFQVEEGEQLVCGSIIPNQHFTQPPAHFSEATLVKTLEENGVGRPSTYAPTITTLLARGYIVKESKILYMTELGEVVNQIMKEYFDEVVDVDFTANMERILDEIASGNVEWKEIIKSFYPHFHHTVEYAESQIENIDLTEHTDIPCEKCGTHMVVRYGKYGKFLGCPNFPECNGTKPWYEETGISCPECNGKILMKKTKKGRSYYGCEHNGEGCEFMSWDKPTGEKCPICGEALIEKGNSKNKKIVCRNSKCNYGKQNKN
(443) DNA topoisomerase 1 [Leptotrichia buccalis C-1013-b]
1
MARKLVIVESPSKAKTIEKILGRNYEVVASYGHVIDLPKTKIGIDVENNFEPQYKVIKGKGEVLKKLKEKAKSANAVYLASDQDREGEAIAWHISNYIKQPDKVKRIEFNEITKTAVNNAIKNPRDINDNLVNAQQARRLLDRIVGYKISPLLWKIINRNASAGRVQSVALKLICDLEDEINAFVPQKYWEVSALIEKDINLNLVKIANEKVDKIFDEKVVKKLKKDLKDESLTIEKIEVKKKSQRPPLVFKTSTLQQLASSYLGYGASKTMRIAQQLYEGLPIDGENKGLITYMRTDSTRISVDALNMAKDYITKNYGEKYVGKYVVKNSKSNVQDAHEGIRPSDINLVPDDIKVYLTNEQYRLYKLIWDRFLVSQFAAMQYEQMQINAVNGDYSFRGTINKVIFDGYYKIFKDEDEIKTGDFPELKEGNVHPIDKLNVEEGITKPPTRFSEATLVKKLESEGIGRPSTYASIVETLKTREYVELIEKRFYPTYLGYEVKDELVKNFKDIMNVKFTANMEKELDKVEEGTVEWVQLLRAFYNSLEKEIKKFEKEIEEMKNRRVVSDVLDSEGKPMILKTGLYGKYLISETNEKEKVSLKGIAVSPEELKKGEIFIKTEVEKLQNNKKGILTDYFDENGNRYVLKVGRFGEYLESENYEKDEKRMSLPAELKQKYKKGAVIELDGVLQINDEMKRLQEIDRKIIEEAGVCEFCGKPYEIKTGRFGKFLACTGYPECKTIKNIKTGKVTRVTEKEEKAKKTVKKATKKTVTKSKSTAAKAKKTTATKKKTTTKKSTAKKSE
(445) DNA topoisomerase 1 [Candidatus Protochlamydia amoebophila UWE25]
1
MGKALIIVESPAKIKTLKKFLGTNFIFESSIGHVRDLPEREFGIDIENDFEPKYTIMPNKEEVISKLLKAAKQCDVVYLSPDPDREGEAIAWHITQVLPPNTNIKRVSFNSITKDAVVKALENPREIDIALVNAQQARRLLDRIVGYKISPLLNRRIQRGRENFLSAGRVQSVALKLVVDREKEIEAFKPIEYWNIGAILKTNQEDRLFRAALYSVDGKRFEKEPIEGKEITIINNKEAADAILKRMKPGPYQVKKVERKEKRRFPVPPFITSTLQQEASRHHGFSSARTMNIAQGLYEGVDLGSDGPEGLITYMRTDSVRISPEAVQEAREFIKKQYGSDFIPSDPKQYSTQKSAQDAHEAIRPASLQNTPEKVQPYLTKEQFSLYQLIWRRFLASQMVAAIYDTVSADILAGEGILLRATGSIIKFQGFLAVYEEKNDDDEKDDENRMLPKLEEGQTLFLQELTSEQAFTRPPPRFTEASLVKELEKSGIGRPSTYAAIMNKIQSRDYTVKENGRLKPTELGQIIAQMLETSFQKIMNIGFTAAMEDDLERVAENMKDWKTLIRDFWEQFNPTLEIALKEAFVPKVMTEIDCPKCKIGKLQKVWARSKYFFGCSRYPECDYSSPVEEITFNKEDYATDFDWEQPCPNCNSEMKIRHGRYGAFLGCTKYPECKGIINIPKKGEEALSQQDLPSCPAIECPGHMVARKSRFGKIFYSCSTFPECDVIVNNLEQVENKYPNHPRTPYEKKGKKAAAKTATKEKTKKTAKANASKATKKIKSTPDKPKKVRQMPVYQVSPELRGIIEVSEITRGDMTKKVWDYIKTHQLQDTNNKRLIIPDAKLSQVFGTTQPVDMFKMATLLSAHLKK
(447) DNA topoisomerase 1 [Rickettsia massiliae MTU5]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQTLEKFSIINEKNAKDLIEKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQDAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMNLVVANLASENKEYLAKANGSTIAFDGFYKVYRESVDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCTSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMVGYGKFGPYIKYMGKFIAVQKKYDFLNLSLDDAMKLIEENKEKLEKKQA
(451) DNA topoisomerase 1 [Eubacterium rectale ATCC 33656]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVMASNGHVRDLPKSSLGIDVDGDFEPKYITIRGKGEILAKLRKEAKKADKIYLATDPDREGEAISWHLLHALKLEGKDVSRISFNEITKNAVKESLKHPRKIDMDLVDAQQARRVLDRIVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWSLDATVDVEGEKKPITAKLYGRGDNKIAISSKEEMDKVLNEINGKDCKVQNIKKGQRSNKAPLPFTTSTLQQEASKALNFPISKTMRIAQQLYEGVDIKGQGTVGIITYLRTDSVRVSDEAEAMAKDFISKSYGDKYLSNGEGTKKSSKNIQDAHEAIRPTDINRVPSEIKESLSRDQFRLYQLIWKRFTASRMAKSEYETTTVKLSVGDYVFSFATSRLLFDGFELAYTAADDAKKEKQPVLKNPLTEESLLTVEELLPKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTISTILARRYITKESKNLYVTEIGEVVNSIMKESFPTIVDEHFTANMESLLDAVAEGKVNWKTVVENFYPDLKDAIDKAENELEKVTIHDEVTDEICPECGRNLVIKYGPHGKFLACPGFPDCRFTMPYLEKIGVNCPKCGKDVVLKKTRKGRKYYGCIDNPECDFMSWGRPVAEKCPRCGGYMIIKGNKIACADEQCGYVTDKKPEREE
(452) DNA topoisomerase 1 [Thermus sp. CCB_US3_UF1]
1
MVVESPAKAKSIQKMLGAGYEVRASRGHVADLPERELGVDVERGFAPTYEVKKDKKPVVEELKRAAQGRRLLIATDPDREGEAIGWHLARLLGRDPQEPLRVEFHEITPKVVREAVARPRPIDQNLVDAQQARRVLDRLLGYNLSPLLSLEFRKRALSAGRVQSVALRLVVEREEAIEAFRPEAYWTLEGRFAVEGQELAASLHEVEGRRLWTGQGDKEGRLHLQSEAEAQALAEAMRGLPFRVAQVETKERRKAPPPPFTTSTLQQAASSRLGYTASRTMRIAQRLYEGVDLPEGTVGLITYMRTDSVRVSPEALQAAREAIAQAFGPAYLPESPRVYKNRREGVQDAHEAIRPTDPRRTPEGVRPYLSEEEYRLYDLIWRRFLASQMREALYDQTVVLLQDQGEKPRFTFRAAGSVLRFEGYLKAWGREGEEEEEAPVPAVAQGAEARLLGVRPEGHTTEPPPRYTDASLVKAMEELGIGRPSTYAPTLETLEKRGYVERKGRTLLPTLLGRQVTRYLKERFPQVVAYEFTARMEDRLDQIEEGKAPWPQVVWEFYEPFLGELAQVPKKACPRCGRPLELKVSRFGQFLGCTGYPGCTYTEPLEKKEAEAIGEVCPRCGRPLLRKEGRYGSFIACSGYPECDYTRDDGKATGHTCPKCGGRVLEKRSRRGKPYYRCESCDFLSFYPLLDKPCPACGWPLAGKGEGACLNPSCPAHDPRLQPSPREERTKASGKGGKPKGKARASSPKPPQDWGDLIPFLPELPPEERQAVEALAQGEALSEEGAKLAKRALFKLRMRKGRARKEVAPT
(457) DNA topoisomerase 1 [Haliscomenobacter hydrossis DSM 1100]
1
MSKNLLIVESPAKAKTIEKFLGKDFAVRSSYGHVRDLDKGNQAVDVKNGFSPKYTISPEKHKVVKELKDWVKKVDEVWLATDEDREGEAISWHLCEVLGLDPKSTKRIVFREITKPAIEKAVQQPRTVDLNLVNAQQARRVLDRLVGFELSEILWKKVKGKLSAGRVQSVAVKLVVEKEREINSFKSEAYFKIEALFDVKNEQGRTVSLKAEGTDRIKTEMDAETFLKKCIGAAYKIQSIDVKPLKRRPTAPFTTSTIQQEASRKLGFSVNRTMVTAQKLYEAGFITYMRTDSINLSETAIASISQEIEKLFGKKYVEVRRFKGKSANAQEAHEAIRPTYIENQTVPGDRDEKRLYELIWKRTIASQMADAELEKTVVDIGISTQPGVSLQAEGEVLKFDGFLKVYLESNDDDEEDEAQGVLPPLKVGQVLPFNQMKATERFTRPPSRYSEAGLVKKLEELGIGRPSTYAPTISKIMEEGRGYVVKENRDGAPRAFRELTLKDAQISKKELSEMTGVIKGRLFPTDMGSTVSDFLDQHFDKIMDYKFTAEIEKLFDDIAAGSREWTEMLGTFYWPFHEIVEETMANADRPTRERILGKEEGTGYSVLTRMTRLGPVVQIGTPEELIPGEKPRYANLKPGQSIETIEMEEAMKLFELPKILGDYRSQEVAVGTGRYGPYVRFGEKFISIPKGEDPLSVTLERALELIEEREKVDAPVASYKGFPITKGTGRFGPFIKWNDTFINVPKKYNLETLTPEEMHELIEGKMEKEANRYIQNWPDEKISIENGRWGPFIRFKKDMLKLPRLDGQKMSPEDAALLSLEDVKKTIEEQVPDAFAKKAPVKKAPAKKAAPKAAAAKGAKVKK
(458) DNA topoisomerase 1 [Halorhodospira halophila SL1]
1
MGKSLVIVESPAKARTINKYLGSDYEVMASYGHVRDLVPKEGAVDPSSGFAMKYAPIDKNQKHVDAIAKAARKADALYLATDPDREGEAISWHLVELLRDKGTLDDKPVYRVVFHEITKGAIQEAMNNPRDISEELVNAQQARRALDYLVGFNLSPLLWRKITSGLSAGRVQSPALRMICERETEIEQFEPQEYWSVEADAAKAQQPFMAKLSQLHGEKVRQFTITDETHAQEVDRTLREAARAQPDPARIGPTGDGETEVIGTLRVASVERKQRRRNPAAPFITSTLQQEASRKLGFTASRTMRIAQQLYEGIDVGEGSAVGLITYMRTDSVNLSGEAITEMRQAITDRYGADKLPGQAQVYKTRSKNAQEAHEAIRPTSASRHPDDVRAYLNEEQRKLYDLIWKRAVASQMKHATIHTVAVDLAADADARHLLRATGSTVADPGFMVVYREGNDEGKDDSGEKFLPELEEGEQVDLHAIRAEQHFTEPPPRYTEASLVRALEEYGIGRPSTYASIISTLQNRNYVEMDGKRFIPTDIGRTVNKFLTEHFDRYVDYDFTARLEDDLDAISRGEQDWVPVLEAFWEPFRERVEEKKNVSRQEAVQARELGTDPKTGKPVTVRIGRYGPFAQLGSRDDDEKPRFAGLRPGQSIDTITLDEALQLFKLPRDMGETDEGEDVQVSIGRFGPYVRYGKKFVSIPKDEDPYTITKERAHELVREKKQADANRIIHDFGDGIQILRGRYGPYITNGEKNAKVPKDREPDSLTHEECQDLIAKAPARKGRRGGAAKGGRGRSKATS
(466) DNA topoisomerase 1 [Lactobacillus fermentum IFO 3956]
1
MSLATKQESTTKKKTTRRKVSRTNQKKLVIVESPSKAKTIGKYLGRTYKVVASLGHVRDLPKSRMGVDIDHDYQPDYISIRGKGDVIKELRKDAKAAKAVYLASDPDREGEAIAWHVANLLKMDPTEKNRVTFHEITKDAVKEAFKEPRTINMNLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALNLIIQRENEIRNFVPEEYWTIDADFKKGREKFQASFYGQNGKKANLKNQEAVQAVLQQLDRQQDFSITKVDRRERRRMPQPPFTTSTMQQDANRRLNFRTRKTMMAAQQLYEGINIGQGAAVGLITYMRTDSTRIAGVAKHEASTFIHEHYGAEYAATKPVKGKLQEGAQDAHEAIRPTSVNRTPAEMKEFLTPDQYKLYNLIWSRFVASQMTPQVTDTMAVTITQNGVDFRANGSKVKFDGFTKVYKGSQGKDNILPNLEEGDAVKMVADNPAQHFTQPPARFTEAALVKTLEENGVGRPSTYAPTLDTIQRRYYVKLESRHFEPTELGEIVNDLITKQFPDIVNVKFTAEVEDSLDKIEEGKENWVQVVDGFYKPFSKEVATAEEQVAKIEMKDELAGSNCEICGAPMVIKMGKYGKFYACSRFPNCRNTKAIVKDTGVECPLCHQGTVVERKSKKNRVFYGCSRYPDCDFLSWDRPIGRDCPKDGHFLVEKKVKGGKQVLCPNGDYKEEVQK
(476) DNA topoisomerase 1 [Neisseria gonorrhoeae FA 1090]
1
MAKNLLIVESPSKAKTLKKYLGGDFEILASYGHVRDLVPKSGAVDPDNGFAMKYQLISRNGKHVDAIVAAAKEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPREIEMDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIRAFEAQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQFDLPNEAAQADVLKELEGKEAVVTAIEKKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDSVNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPFLSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFAGFLSVYEESSDDEESEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEYGIGRPSTYASIISTLKDREYVTLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLEDQLDEIADGKRRWIPVMDKFWKPFIKQVEEKEGIERAKFTTQELDETCPKCGEHKLQIKFGKMGRFVACAGYPECSYTRNVNETAEEAAERIAKAEAEQVELDGRECPKCGGRLVYKYSRTGSKFIGCANYPKCKHVEPLEKPKDTGVQCPQCKKGNLVERKSRYGKLFYSCSTYPDCNYATWNPPVAEECPNCHWPVLAIKTTKRRGVEKVCPQKECGWKEQIEPPAPQE
(477) DNA topoisomerase 1 [Candidatus Midichloria mitochondrii IricVA]
1
MNLLIVESPAKAKTIGKYLGPSYKVISSYGHVRALPSEEGAVDPEHDFAMRYEIPPKAAKQIAAIVAEAKHSDHIYLATDPDREGEAISWHVLEILKQKKAIKNSTKVYRAVFHEITKKAIADSLKTPRDLNNDLVSAQKTRQGLDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRMICEREAEIESFKSQEYWSIHGRFSTEKGEEFDSTLIEFQGKKLEKFTTVNEAQAADVISKIKDNSFSVKRVEKKKVNRNPQAPFSTSTMIQEASRKLGFSAKKTAQIAQKLYEGININGELTGLITYMRTDSTSISAEATKAASELITKIYGSNYLPPSPRVYKTKTKNAQEAHEAIRPTDVFKKPESIKSFLEEDQFKLYELIWNRLVASQMASAILDVMTVDIADDQGNTFRATGSSIAFSGFYKVYREGIDDADEEKDRILPILKEKELLKLLEAIKEQHFTQPPPRYTEASLVKRMEELGIGRPSTYPTIISILQDRKYVIFEKKRFIPEPRGRLVNTFLTLFFNQYVEYGFTANLEEQLDEIAAGKVIWKKVMKDFWYPFKNKTDEVLSIKTSEILAKMEEQLLNYLFHKEILQDSKSIEEVLKCSKCVTGKLQLKNGRFGSFLACSNYPNCNYTKAIGSNDNNMQDTCNEPAVADLPKVLGTDPNTKEEVSIRKGPYGFYVQRGEGKKVKRTGLPKDLNYQNIDLNYAIGLLNMPRELGLDQEGVLIRAGAGKFGPYLERSGKYISLRTARIDPVLITLEEALGIIKKSSSDKKDKSSQGKRSAKATI
(478) DNA topoisomerase 1 [Ammonifex degensii KC4]
1
MKHLIIVESPAKARTLSKFLGSQFLVKASMGHVRDLPKSELGVDLENGFTPKYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWHLCHLLGIPPETPCRVEFHEITKNAVLNSLKSPRPIDLNRVNAQQARRVLDRLVGYGLSPLLWRKVKRGLSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLARLARFKGKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQEANRRLGMRLERTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIKEHYGAEFVGDVPPKERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLIWERFLAAHMAPAKYFLTRAEIEVGDYTFYATGRQLLFPGFLRLWRPEEEEEEGKLPPLREGEVLTFQEFVPQQHFTTPPPRYTEGTLVKALEEKGVGRPSTYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLKEHFPGIVDVGFTAAMEEKLDLVEEGQADWVDILREFYQSFSQDLVRADAAIEKVSLPDTFTDISCPRCGCPMVKKTGRYGEFLACSGYPECQMRMPVGTGVKCPRCGGELVKRRSKKGRYFYGCNRYPECNFVVWSEPVPEPCPECGSLMVRRGRGKKKRVICTNESCGYQRLEE
(483) DNA topoisomerase 1 [Riemerella anatipestifer ATCC 11845 = DSM 15868]
1
MPKNLVIVESPAKAKTIQKYLGKDFEVLSSFGHIRDLPKKGMGINLNTFTPEYEVSTDKKELVSDLKAAAKKADMVWLASDEDREGEAIAWHLAQELKLKDEKIKRIVFHEITKNAILKAIENPRNIDKNLVNAQQARRVLDRIVGFEMSPVLWKKVKTGLSAGRVQSVAVRLIVEKEKEIQDFVPNSYYKTEGKFLNADNQEISAQLKKSFFEESEAKEFLTLAKNTAFKVLNIEKKPGKRTASAPFTTSTLQQEASNRLGYGITTTMRVAQRLYEEGYITYMRTDSVNLSQEAIEGAKEQIIKEFGQEYSEPRNYTTKSSSAQEAHEAIRPTDFKLKTVAGDTQLNRLYQLIYKRTLASQMANAQIEKTVVEIGNPKLPYNFEAQGEVIVFDGFLKVYGILKSEEEDAEDTEKTLPKVSVGESLTYQNIISVQKFTRPPARYTEAGLVKKLEELGIGRPSTYAPTIQTIQNREYVDKKEIAPQEREVIKLNLTSNKIDRKVLTENYGGDKNKFVPTDIGIVVNDFLTKNFAEVLDYGFTAKVEQDFDDIANGDEKWKEVLSGFYEKFHDKIEDVEENADRANGERILGEDPKTGKTVLVRIGRYGAMAQLGDSDDDNPIYSSLLSHQNINTITLEEALDLFKVPFDLEKVDGKTVSVGVGRFGPYVKWGETYISIPKEEDPLTVNQKRAEELIREKQKADAPITTFKGEPVTKGTGHFGPFLKYKNIFVNVPKKYDFENLSQDDIVELIEAKLEKEANRYIKQWEKEGISIENGRWGPFIKFNKTNFRIPKNGDEKYTAEELKEVPLEEIKKWIVAQDKNAFAEKKTTKKKTVTKKK
(484) DNA topoisomerase 1 [Riemerella anatipestifer ATCC 11845 = DSM 15868]
1
MPKNLVIVESPAKAKTIQKYLGKDFEVLSSFGHIRDLPKKGMGINLNTFTPEYEVSTDKKELVSDLKAAAKKADMVWLASDEDREGEAIAWHLAQELKLKDEKIKRIVFHEITKNAILKAIENPRNIDKNLVNAQQARRVLDRIVGFEMSPVLWKKVKTGLSAGRVQSVAVRLIVEKEKEIQDFVPNSYYKTEGKFLNADNQEISAQLKKSFFEESEAKEFLTLAKNTAFKVLNIEKKPGKRTASAPFTTSTLQQEASNRLGYGITTTMRVAQRLYEEGYITYMRTDSVNLSQEAIEGAKEQIIKEFGQEYSEPRNYTTKSSSAQEAHEAIRPTDFKLKTVAGDTQLNRLYQLIYKRTLASQMANAQIEKTVVEIGNPKLPYNFEAQGEVIVFDGFLKVYGILKSEEEDAEDTEKTLPKVSVGESLTYQNIISVQKFTRPPARYTEAGLVKKLEELGIGRPSTYAPTIQTIQNREYVDKKEIAPQEREVIKLNLTSNKIDRKVLTENYGGDKNKFVPTDIGIVVNDFLTKNFAEVLDYGFTAKVEQDFDDIANGDEKWKEVLSGFYEKFHDKIEDVEENADRANGERILGEDPKTGKTVLVRIGRYGAMAQLGDSDDDNPIYSSLLSHQNINTITLEEALDLFKVPFDLEKVDGKTVSVGVGRFGPYVKWGETYISIPKEEDPLTVNQKRAEELIREKQKADAPITTFKGEPVTKGTGHFGPFLKYKNIFVNVPKKYDFENLSQDDIVELIEAKLEKEANRYIKQWEKEGISIENGRWGPFIKFNKTNFRIPKNGDEKYTAEELKEVPLEEIKKWIVAQDKNAFAEKKTTKKKTVTKKK
(485) DNA topoisomerase 1 [Candidatus Atelocyanobacterium thalassa]
1
MSTLVIVESPTKARTIRNFLPSEYQVEASMGHIRDLPASASEIPASYKGKSWANLGVDVENNFDPIYVIPKDKKKVVQGLKTALKSVDELILATDEDREGESISWHLLQILKPKVPIKRMVFHEITKDAIQESLENCRDINENLVHAQETRRVLDRLYGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVQKERERLSFQSGEYWNLKVLLKKEEIFFEAKLISISGKKIAIGSDFDPKTGGLAGNRNIILLDEQEANILKEQLKDTNKTWNVVKVEEKKVSNKPFPPFTTSTLQQESNRKLGISARDTMRIAQKLYEEGYITYMRTDSVNLSSEAINAARKCVKKKYGEEFLSPHPRKYTTVSKGAQEAHEAIRPAGNIFLIPKETGLTDQRLSLYDLIWKRTVACQMADAQLTQVSVIIAVENAEFRAYGKRIDFPGFFRAYVEGSDNPEIALENQEIILPYLQEGEHLKCEQVDAISHKTQPPARYTEASLVKILEKEGIGRPSTYASIIGTICDRGYSQMRSKALVPTFTAFAVVSLLETYFPELVDPMFTSKMEQALDEIATGEVLRVPYLEKFYFGDKGLDTQVKVRTDEINPSLAKAINLHNLDTTIKIGKFGPYIEVEQNEKIITASIPADLTPSDLNIDQVTKILKQKTEGPEKIGLHPDIGEPIYLLIGSYGPYVQLGEITEENKKPKRTSLPKSIKPEDVNLEIALGLLALPRLLGTHPDTQASIKVNIGRFGSYVVHDQGKEGKDYRSLKKEDDLLTISFERALELLSQPKLTRGRRTKKPLKELGLHPEDNEPINIYEGPYGVYINHKKINVSLSKKDKIDDITLEKALKLLLKKTPAKKTPAKKTPAKKATAKKATAKKIN
(486) DNA topoisomerase 1 [Lactobacillus casei ATCC 334]
1
MADKKLVIVESPAKAKTIEKYLGRTYKVVASLGHIRDLPKSQMGVDVDNDYEPKYISIRGKGDVIKSLKKDAKKASKIYLAADPDREGEAIAWHVSHILGLDPKAKNRVVFNEITKDAVKNAFKTPRGIDMDLVDAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKNFTPEEYWSLDAEFQKGRSKKFSASFYGLKNKKQALKNNEAVQKILGQVDKTKPFAVTNVVKKERKRFPSPPFTTSTLQQEANRKLGFRTRKTMMLAQQLYEGINLGGKLGTVGLITYMRTDSTRVSNVAKTETSHYLHEKYGEAYAAVKIRQGKLQEGAQDAHEAIRPTSTLRTPDSLTAVLDKDQMKLYRLIWSRFVASEMTPAIIDTVAVTLDQNGVTFRANGSQTKFEGFTKLYVSSRDSDQKDNILPPLAVGDDVKMLKTDPAQHFTQPPARYSEANLVKALEENGVGRPSTYAPTIETIQKRYYVKLNARRFEPTELGEIVNSLIVEFFPDIVNVKFTANVESELDRIETGEADWVKVIDQFYKPFEKEVAHAETGIAKIQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPNCRNTKAIVKEIGVVCPKCHIGQVVERKSKRNRVFYGCSRYPDCDFVSWDKPVGRDCPVCGHFLVEKKSKAGTQVVCPNNDYKEALQKA
(487) DNA topoisomerase 1 [Gluconacetobacter medellinensis NBRC 3288]
1
MTDVVVVESPAKAKTINKYLGDNYTVLASFGHVRDLPPKDGSVLPDEGFAMKWEADERGSRQIAAIAKALRGAKHLYLATDPDREGEAISWHVRSMLEEKNLLKGIDVQRVTFNEITKSAIKTAMAHPRELDFPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFRPREYWSITARMTTPAGAAFSARLTHLDGHKLDQFDLGDEARAMAAKAAVEAGDYSVDKVERRKVRRNPPPPFTTSTMQQEASRKLGMGAQVAMRTAQQLYEGIDIGGETVGLITYMRTDGVQMAGEAIGAIRGHIGHSFGPEYVPEKARIYSTKAKNAQEAHEAIRPTDVRRTPADMARYLSPEQKKLYDLVWKRSVASQMQSAELDQVAVDITDRQQRVTLRATGSIIAFDGFLRLYSEGRDDSPAKSDDDQDRMLPAMSEHDAIGRGEVAADQHFTQPPPRYSEASLVKKMEEIGIGRPSTYASILTVLRDRNYVQLENRRFVPEDRGRLVTAFLTSFFERYVDTQFTAGLEEQLDDISGGRANWRDVMSAFWSDFSHAVDQTKDLKISDVITALDADLAPYFFPDREDGQDPRVCTACGTGRLGLKLGRYGAFIGCSNYPTCQFTRKLVIDPSKEGEDAATLKDGMRVLGTAPTGEEVTVRRGPWGLYVQQGEPDPEDKKAKPRRATIPRGLDGDKITLVQAVGLLSLPRIVGIHPELGEPIEAGLGRFGPYVKMGAIYGSLDKDDDVLTVGLNRAVDALAKKLASIRTIGPHPKDGEPVMVRKGRFGPYVQHGTIVATVPRGQDMADVTMEEALTLLNEKGKPLKAKGKKATTTRKPAARKTKAKAAEGTEDAGAAPKKKAAPRKAASKAKTATKTTTRKKATPAKAESESD
(491) DNA topoisomerase 1 [Synechocystis sp. PCC 6803 substr. GT-I]
1
MSKLVIVESPTKARTIRNYLPQDYRVEASMGHVRDLPASAEEVPAAYKDKSWANLGVNVEDHFSPLYVIPKSKKKVVKELQTALKNADEVILATDEDREGESISWHLLQLLQPKVPIKRMVFHEITQEAIRSALENCRDIDENLVHAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLIVQRERARRAFKTAGYWDLKAELEQNKNPFQAKLMTLGGTKLANGSDFDPNTGALLPDKQVVVLDEAQAIALKERLTGKPWAVVNTEEKPGVRKPSPPFTTSTLQQEANRKLGISARDTMRVAQKLYEEGYITYMRTDSVHLSDQAVTAARNCVQQMYGKEYLSPQPKQYTTKSKGAQEAHEAIRPAGTEFRIPNQTGLKDRELALYELIWKRTVACQMADARITQLSVLLKVEDAEFRAAGKRIDFPGYFRAYVEGSDDPDAALENQEVILPPLKVGDRPNCREIDTVGHETQPPARYTEASLVKTLESEGVGRPSTYASIIGTIIDRGYVQMRSKALTPTFTAFAVVSLLESHFPDLVDTGFTSRMEQKLDEIAIGKTQWLPYLQGFFLGESGLENQVKVRQDQIDPAIAKAIELENLAAKVKIGKFGPYIEIPQGEEIITASIPQDLTPADLNPEQVAVLLKQKTEGPDKVGIHPETGEPIFILIGAYGPYVQLGEATEENKKPKRTSLPKGVKPEDVTLEMAVGLLALPRNLGEHPESGKNIKASLGRFGPYVVHDQGKDGKDYRSLKGDDDVLTITLERALELLAEPKRGRGSRTPLKQLGLHPEDQEPVNLFKGPYGVYIKHGKVNASLPEGETEETITLEKALPLLAEKAGSGKKTSRKKATTTAKGTKKTTSKKASATGTAKKTTTKRTTRKKAASPDQSSEAG
(492) DNA topoisomerase 1 [Thermotoga thermarum DSM 5069]
1
MSKKVIIVESPAKAHTIQEILNDEYEVLASKGHVRDLPEDEFGVNLKKDFEPKFEIIKGKEKTIQELKEKTKGKSVFLASDMDREGEAIAWHLSLLLGLKNGKNRIIFSEITPKAIREALKNPREIDMKKVEAQIARRILDRIVGYKISPLLWRALKANLSAGRVQSAALRLLCERELQRYKFEPKKFWRVEGYIGEIKFKLTHIDGKKIEMQDVNEKLAKQIEQAVVTLNVTRVSRRTIRKKSPDPFITSTLQQEAANKLGFSVSKTMQIAQQLYEGVETKEGHKAFITYMRTDSTRISDYARQQAEKYIKENFGEKYIGEVRQLKKTKNVQDAHEAIRPVDVYVTPERAKNLLQSDQYKLYKLIWDRFLASQMADAVYEETTIFLESGQYGFEAKVERPIFDGFELIYGKTASKNVKIPQGTVKVDRWEIVEDETKPPARYTEASMVRALEAKGIGRPSTYATIISTLLERKYVVKRGKELVPTVIGFVVNNYLQERFPSVVDLEFTARMEEELDKIEQGKKNYKEILRDFYNDFSDYLNKAQESWFSIDFKTNKLCECGESLTLRVGKYGLYLTCKKCSKSQSVRLDELAVLDKDTMYFYEENFEKKFCPSCGEQLKQVRGKYGVFQRCEKCGKTYGLFAEGECPKCGSAVERKTSKSNKVYYKCTNQDCDFISWLEPAKEKCPNCQNQLYYKVIGSRKRLFCANCNKTIWKRKS
(493) DNA topoisomerase 1 [Desulfovibrio alaskensis G20]
1
MGKDLIIVESPAKVKTIKKFLGNKYMVQASVGHIRDLPTKELGVDEENDFSPDYQVIQGKQKVVSALREAAAKADNVFLAPDPDREGEAIAWHVAEIIAKENKNISRIQFNEITARAVREALENPRELNRSLFDAQQARRVLDRLVGYKISPILWNKIKRGISAGRVQSVALRLIVDRERERYAFTSEEYWVFRANLAAETPPPFKAELFKVDDKKPAIASAEQAQELEKSIEGKAFIVDSVQEKERSRKPQPPFITSTLQQLASQRLGFSAKRTMSVAQRLYEGLDLGDMGTTALITYMRTDSVRISDEARDSARELIASLYGKEYCPAKAPVYKTKGSAQDAHEAIRPVDVTLTPDKIKGLVAPEQYSLYRLIWSRFMASQMAPARFHDTTVLIGCGGTQWRVKGERLLFPGYMAAAPASAKEANVELPPMQQGQTLELTLLEKEQKFTQPPARYSEASLVREMEEKGIGRPSTYASIISTIVDRDYTRLEEKHFVPTDLGFVVCDMLTNHFGTLMDIGFTAQMENSLDKVAEGDLDWVALMKDFTSDFNPTLASAAKEMKTVKAGLETDIVCSECGKPMAIKFGKAGPFLACTGYPDCKNTSNFTRDESGTIQLVEREQEELKPVGTCPECGKDLVVKQARTGSRFIACTGYPDCKHTEPFSTGVPCPNDGCDGQLVEKSSRRGKIFYSCNRYPQCDYATWNWPVAEACPQCDSKILTIKSTKARGKHIACPACKYTRALEDEE
(494) DNA topoisomerase 1 [Bartonella bacilliformis KC583]
1
MDIVIVESPAKAKTINKYLGSQYKVIASFGHVRDLSAKDGSVLPDKDFSMKWDVDTASAKRLNEIAKAVKEANSLILATDPDREGEAISWHILDVLNQKKILNDKPVKRVVFNAITKQSVLDAMNNPRDIDVSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEREHFVKEDYWSITTYLKTPRNDVFQARLIEFNQKKLSKLDIQSQEQANQIRLMLEEAEYCTLSVEAKPTKRNPSPPFTTSTLQQASSSKLGFSASRTMQIAQKLYEGVEMNGETAGLITYMRTDGVQIAPEAIDSARRAISNSFGNNYLPEKPRFYSTKAKNAQEAHEAIRPTDFKRHPDQVRNFLDNDQAKLYELIWKRAIASQMRSAEIERTTVEIKAVQEENYANLRATGSVTRFDGFIAVYTDQRDETNGDEDDLARLPPINVNEILTKEKIETAQHTTDPPPRYSEASLIKKLEELGIGRPSTYASTLATLCDRGYIIIDKRQLTPDAKGRIVTAFLENFFNRYVEYGFTANLEEKLDLISDGKLFWKDVLRDFWDEFNASVTNIQELRITNVLDVLNTTLAPLAFPTREDSSDPRSCSLCKHGQLSLKLGRYGAFVGCSNYPECKYTKQLGTDAGEEREAAHNDEPVILGVDPETGKDIFLRNGRFGPYIQLGEGKEAKRSGLPKGWKTENVNLDKALSLLSLPREVGIHPETGQMITATIGRYGPYLTHDRKYAALSNVDDVFDIGINRAVTVLAEQKENKANRGKTVSSVLAALGDHPDGGSITVRDGRYGSYVNWGKINATLPKDKDPANITLSEALELLSAKTSAPSKTRKVAAKKTAPKKNTTVKKASSTIKKAK
(496) DNA topoisomerase 1 [Rickettsia japonica YH]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPNENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKAIIHAVENPRKLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTEKLKSQKFHVDKIEKKQQKRQPQPPFITASLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAQANGSTIAFDGFYKVYRESMDDKAEEANKMLPPLKEQEPLKTKKVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKPA
(497) DNA topoisomerase 1 [Geobacter bemidjiensis Bem]
1
MSQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPESKKHIDAIKKEMKGISSLLLATDPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITKDAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKLGGKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQLLPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFTQYVDYNFTANLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVNKSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEEICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFGKLFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS
(498) DNA topoisomerase 1 [Acidiphilium multivorum AIU301]
1
MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGDRQVAAIAKALKGADTLYLATDPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEVTKSAVQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICEREAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVERGAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVGLITYMRTDGVQMAREAITAARQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFTLTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTVELADAAGTTLRATGSILAFDGFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEELGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEEKLDEVSDGRLDWRSVMRDFWADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDPRVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEGGEDEGDQLRDGMKLLGENAEGIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGVHPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHPKDGESVTARKGRFGPYVQHGKTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAKPAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPKAAAAKAKPAARKTARSGG
(499) DNA topoisomerase 1 [Caulobacter crescentus CB15]
1
MNVVVVESPAKAKTINKYLGSDYTVLASYGHIRDLPSKDGSVEPDNDFAMSWEVDAKASKRVSDIVDAMKKADRLILATDPDREGEAISWHVLEVLNKKKALKDKTVQRVTFNAITKTAVTEAMKAPRDLDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVVDRELEIERFKTQEYWTVDADVSAGSDPFLARLVKHEGKKLTKFDLGNETSALTAKAAVEAAVFKVEAVEKKPGKRSPAPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVSMAPEAIFEARDVIGAVYGKEYVPDSPRMYKSKAKNAQEAHEAIRPTAMGRNPGSLRLEPELGRLYELIWKRTIASQMESARIERTTVDLTSADGQTGLRATGQVVQFPGYLAVYEEGRDDEGDEDSARLPAITEGASAKVLKSRADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASVLGVLRDREYVRMEKQRFIPEDKGRLVTAFLEQFFKRYVEYDFTAALEEKLDLVSDGKLDWKEFLREFWKDFHAAVGEIAELRTTNVLDALNEALGPHIFPDKGDGSNPRLCPTCGSGQLSLKTGKFGAFIGCSNYPECRYTRQLGVSEGDGDAESADKQLGLNPATGLAVWLKNGRFGPYVEELAAEGSSDKPKRSSLPKGWIASAMDMEKALRLLSLPREVGKHPDDGKVITAGLGRFGPFVLHDGTYANLENADEVFDVGLNRAVAILADKRAGGGRPQRGAAAALAELGNHPEDGKPIRVLSGRFGPYIKHGDTNANVPKGKDPAAITLEEALALIAERAAKGGAKKPAKKAAATKSKAKAESDAPAKKTAAKKPAAKKPAAKKAAPKAKAKATAASDDGAAPWDDEG
(501) DNA topoisomerase 1 [Bacillus pseudofirmus OF4]
1
MADYLVIVESPAKAKTIGKYLGKKYIVKASMGHVRDLPKSQMGVDVEENFQPKYITIRGKGPVLKELKTAAKKVKRIYLAADPDREGEAIAWHLAHSLNIDEQSDCRVVFNEITKQAIKDAFKTPRKINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIEREKEIQAFVPEEYWTIQGKFSLGDEAFDAKFYGVDGKKQELKSEEEVQAVLKQLKGKSFDVASVKKKERKRNPVTPFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISETAQNETRQYIVEQFGEEYTRVGQRAVKKDKKAQDAHEAIRPTAVFKDPKSLKSYLSRDQLRLYRLIWERLVASEMAPAIMDTMSVDLVNEGVLFRATGSKVKFPGFMKVYIEGNDDGKKEEDRLLPNLEEGQKVKKESIDPNQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQKRGYVALEEKRFVPTELGEIVLELIVEFFPEILDVEFTAKMEGDLDSIEEGNHEWVHIIDGFYQGFEKRLKVAEEEMKEVEIKDEPAGEDCEKCGHEMVYKMGRYGKFMACSNFPECRNTKAIVKDIGVKCPTCKEGNIVERKSKKRRTFYGCDRYPECEFISWDKPISRPCPKCSAMLVEKKTKKGVNVQCSSCDYKEEAN
(502) DNA topoisomerase 1 [Sulfurihydrogenibium azorense Az-Fu1]
1
MKKVLIVESPKKAKEISHYLGKDFIVKATVGHFKDLPEDEMGVDLQTYQPKFVIKSSNHKKILSEIKKLSQDAEVYIATDPDREGYAIGYFMWEELKKKAKTVKRAEFHEITKDHIVEKIKEAVDFEKTNFGLFNAFLGRRVGDRIVGYTLSPIASREIGGRFSVGRVQSPAVRLIVEREREILNFKPTPYYVLTALLEKDGIKFTALYEKQKIEDKQEAEKIYQDIKDEKTAAVEKVEKKQIKQSPKPPFTTSTLQQSANSVYRFPPEKTMMLAQDLFESGLITYHRTDSTRLSDQAITGIRKLIEKEFGKEYLPKNPRVYKSKNTQADAHEAIRITNFVPLKDQEALVKEKGLSEDHFKLLKLIYERTVACQMEDAVFERTNITLKIKNHTFKASGSILKFKGYKAVYDLEEDDEESQSLPKIEKNQLINIQSINLEEKFTKPPARYTEGSLVKKLEELGIGRPSTYATIIKTIKERGYVVKEGSSLKPTDLAFHLVDYLNQKYNWVIDYNFTKKMEEFLDKVEENKKDWKEFVKHLHQKSVSTTRSKVSKKMLDYAKDLAKKHGKDIDAILDDPQKLKEFINDHADKKPSEKQITYAKSLSEKTGLPLTEKELSDKKLLTKWINKAKKEALKNYQLSEKQKNVLIKYGREDLIEKPAEALKFIASKLKRFKK
(503) DNA topoisomerase 1 [Mesorhizobium ciceri biovar biserrulae WSM1271]
1
MDVVVVESPAKAKTINKYLGKNYKVLASFGHIRDLPAKDGSVRPDEDFAMSWAVDTASGKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLKQKRALKDKPVSRVVFNAITKSSVLEAMANPRQIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFIREEYWQIAALLGTPRNENFEARLTAFDRKKLQKLDISNKAQADDIKSMLEGATFKAVSVEAKPTKRNPGPPFTTSTLQQAASSGLGFSASRTMQVAQRLYEGMEIGGETTGLITYMRTDGVQMAPEAIDAARDAIAKEFGPKYLPEKPRQYTAKAKNAQEAHEAIRPTDFMRTPASVRQYLDSDQMRLYELIWKRAIASQMQPAEIERTTAEIEAVNGSRTAELRAIGSVVRFDGFIAAYTDQKDDDAEDEENRRLPEIRAGEQLARQAINATQHTTEPPPRYSEASLIKKLEELGIGRPSTYTAILKTLEDRDYVTIDKRRLVPQAKGRLLSAFLESFFKRYVEYDFTASLEEKLDEISDGKLAWKDVLRDFWKDFSGAVADIKELRVTDVLDALNEELAPLVFPAREDGSNPRICPKCGTGNLSLKLGKFGAFVGCSNYPECSFTRQLGDAANPNGENGGGEDGTKVIGKDPYTSEEITLRSGRFGPYLQRGDGKEAKRSSLPKGWTAESIDHEKALALLSLPRDVGQHPETAKMISAGLGRYGPFVLHDGTYANLESIEDVFSIGLNRAVSVIAEKQLKGKGGRNGGTAAALKELGDHPDGGGKIVVRDGKYGPYVNFGKVNATLPKGKDPQSVTMEDALALIAEKEAKGGGGKKPFRKAAAAKAPATKKVAAKKPAAKKPAAKKKG
(504) DNA topoisomerase 1 [Xanthomonas albilineans GPE PC73]
1
MSKHLLIVESPAKAKTINKYLGKDFHVLASYGHVRDLIPKEGAVDPDDGFAMRYALIDKNEKHVDAIAKAAKAADDIYLATDPDREGEAISWHIAEILQERGLLKGKPLHRVVFTEITPRAIKEAMAHPRQIAGDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFLAREYWTIGAECAHPSQPFAAKLVKLDGQKFEQFTITDGATAEDARMRLQKAAQGALHVTDVTSKERKRRPAPPFTTSTLQQEASRKLGFTTSRTMRVAQKLYEGVTVGDEGTVGLISYMRTDSVNLSQDALVEIRDVIARDFGTGALPDKPNTYQTKSKNAQEAHEAIRPTSALRTPAQMAKYLDDDGRRLYELIWKRAVACQMVPATMNTVTVELAAGSEHSFRASGTTVIDPGFLAVYEEGKDQKAAEDEDEGRKLPAMKPGDRIPLDRIHADQHFTEPPPRYSEASLVKTLEEYGIGRPSTYASIIQTLMFRKYVELDARRFRPTDVGRAVSKFLSGHFTRYVDYDFTAKLEDDLDAVSRGEEEWRPLMEKFWGPFKELVEEKKESVDRSEATGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEDKPKFASLRPGQSMHTITLEEALELFLMPRLLGQDKGDDVSVGIGRFGPFAKRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKQFPDSDIQVLNGRFGPYISDGKLNGKIPKDREPSTLTLDEVQKLLEETGKPVRRGFGAKKVAAKKEAAPKKSPAKKTVADTPTKTAAKKAVKKATKKTVKKAVKKAAKKTVAKVAKGA
(505) DNA topoisomerase 1 [Streptobacillus moniliformis DSM 12112]
1
MAKNLVIVESPSKAKTIEKILGSNYEVLASVGHCIDLPKSKIGIDIQNDFKPDYKIIKGKKDILEKLKEKSKKANKVFLASDLDREGEAIAWHISKYINQDSKVKRIEFNEITKTAISNAIRNPRDIDTNLVNSQQARRLLDRIVGYKISPLLWPIVGKKASAGRVQSVSLKLICDLEEEIKNFISQKYYEIDILINKEIKLNLSEIDGEKIDKIFDEKIFKKAFSDLENSEVMVDEIKISKKSQKPPVVFKTSTLQQLASSYLGFNATKTMRVAQRLYEGLNIEGESKGLITYMRTDSIRVSEEAKFEAKKYIEKKYGKEYVGNYYISDKKNIQDAHEGIRPTDINMSPEKIEKYLTNDEYKLYKLIWDRFLVSQFANVKYDQMQIVASKDKYVFKGNINRITFDGYYKIFKSEDMIQTEDFPELKEKHEYKIDEILTKTGDTKPPARYSEATLIKKLESLGIGRPSTYASIIDAIKEKKYVDIVEKRLVPTIFGKEVKILLENNFKNIMNIKFTASMESKLDDVATGKTFWVDLLKEFYNHLLDEMDVYKQKVDELKNRVIYTDMECSNGKGKMILKSGSFGKYIVCEFDSSEKISIQGIELTEEDLNKDVVQIKDKVEKLMEIRKGLKTDMLTPNGSKYLLKIGRFGEYLESEDYENDKLRKTLTKDLKLKIKKGTLKPVDGVYLLREYFEKLDNENEKILELAGKCEKCGSEFNIKIGRFGKFLACSGYPQCENIKKIPKSDNAKKRVTKNKAKAKTTKKNKKK
(508) DNA topoisomerase 1 [Anaplasma centrale str. Israel]
1
MMGVVIVESPSKAKTISKYLGGKYKVVASFGHVRDFPAKSGSVDPDDDFRMIYEIIPKSEKYIDKIVKAVSSEKSGIYLATDPDREGEAIAWHIIEVLRERSAIGGDVAINRMVFNEVTKRAVTAAISDCRSINMDLVHAQQARRVLDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLVCEREHEIERFDSKEYWNIEVLLKSKSGEELTAALKCYNGEKLDKFAIPNADSASAIAEHVRNGTYHVASVEAKRTKRNPHPPFITSSLQQEASTKLGFSAKNTMMVAQKLYEGIDIGGETVGLITYMRTDGFYISSEAISYIRDTIKMQFGEQYLTKSPRKYVKKVKNAQEAHEAIRPTDITMTPDSLAQYLSEDQLKLYDLIWRRTMASQMESAVIDQVIVDIQSKDGSVVLHAVGSSLGFDGYQRVYGTDDDDKRKMLPKLEAGEDCSLVEVSPSQHFTQPPPRYSEASLVKKMEEIGIGRPSTYATIISVLQERGYTQLEQKKFVPSERGRIVNAFLTNFFGRYVEYDFTANLEEELDLISNGNMAWKEVLRRFWDKFISDVSTVKGIEVSEILKSITKDLEEYAFSPNAGEAVNRSCPGCGEGELMLNIGKYKAFLGCNRYPECKYTRGVGGDSGVCRDEFPKVLGLDDATQEEIILKHGPYGEYLQLGDNAKGKRVAVPQGIQEITLDVAKKLLSLPITLGHYPNTAQDVKLGTGRFGPYVLYGGTYFSVKGREDFWNLTFEEAVNVIDSQAQKKSKLLGLHDNGKEIYVCKGRYGFYLKCDKKNVAIKGKGGDITLEDAVSLLNQKP
(511) DNA topoisomerase 1 [Macrococcus caseolyticus JCSC5402]
1
MAENLVIVESPAKAKTIEKYLGKKFKVVASMGHVRDLPRSQMGVDTENDFEPRYITIRGKGPIVQDLKKHAKRAKHVYLASDPDREGEAIAWHLAHILNIDEKAASRVVFNEITKDAVKESFKHPRQIEQNLVDAQQARRVLDRLVGYNISPVLWKKVKKGLSAGRVQSVALKLIIDREEEINAFKPEEYWTIDGLFEYDRKQFKAKFLHENNKPKKLKQEDDVKAIVKQLKSDAFEVTDVTKKEKLRNPAQPFTTSSLQQEAARKLNFKARKTMMLAQQLYEGIDLKKQGAVGLITYMRTDSTRISDTAKNEAASYIEEHYGKAYLSKRSSKSGGAQDAHEAVRPTSVMRTPSEMKAYLSRDQLRLYKLIWERFMASQMAAAVIDTVSVDLVQNNIKFRANGQTIKFKGFMSVYIEGQDEETEDGENKLPVLEVGDTVKAVNIDENQHFTQPPPRYTEARLVKTMEEKGIGRPSTYAPTIDTIQKRNYVKVDQKKFYPTELGIIVNESVKEYFPEIIDVDFTVNMETLLDKIASGDMEWKKVISTFYGDFKTHVERAEAEMEKIEIKDEPAGEDCEKCGSPMVYKMGRYGKFMACSNFPECRNTKAIVKTIGVACPKCKDGEVVERKSKKNRIFYGCSNFPECDYISWDKPIARNCPKCDTQLVERKKGKQTQVVCTNCDYDEKPQ
(513) DNA topoisomerase 1 [Geobacillus kaustophilus HTA426]
1
MSDYLVIVESPTKAKTIERYLGKKYTVKASMGHVRDLPKSQMGVDIDHGYEPKYITIRGKGQVIKELKTAAKKAKKVFLAADPDREGEAIAWHLAHMLDLDIHSDCRVVFHEITKDAIQQSFQQPRAINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREREIREFQPEEYWTIQATFQKEGETFAASFYSIDGQKRDLKTEADVKAVLDRLNGTAFAVKTVTKRERKRSPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVAETAQQEAAAYIEATFGAMYVNQEKRKEKKSTNAQDAHEAIRPTSAFRDPDKVKPYLTRDQFRLYKLIWERFIASQMAAAVLDTMSVELENNGVVFRASGSKVKFPGFMKVYIEGTDDQTEEQDRILPDLEEEETVESETIESKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVVELMLEFFPEIIDVEFTAKMEKELDEIEEGKVEWIKVVDEFYREFEKRLKVAEKEMRAVEIKDEPAGIDCEVCGSPMVYKMGRFGKFIACSNFPECRHTKPIVKEIGVKCPKCREGNIVERSTKRKRVFYGCDRFPDCDFVSWDKPLARPCPKCAGLLVEKVLKKGVQVQCTACDYEERLEA
(515) DNA topoisomerase 1 [Calditerrivibrio nitroreducens DSM 19672]
1
MSKNLVIVESPSKAKTIEKYLGKDFKVTASMGHIKDLPEKDLGIDIENNFKPKYEILTGKKKIIKEIKKLAEDAQKVYLAPDPDREGEAIAWHIAEEIKDKNRNIFRVSFNEITEKGVQEGIKNPTEINIKRVNAQQSRRILDRLVGYQVSPLLWKPIKYGLSAGRVQTVALRLIVEREEEIEKFVPKEYWTIHGIFNVSESEIKGKLEKIDGKKAEIPDEKKVKEILEDLENKTGLISNIEKKEGKQSPYPPFITSTLQQEAIKKLGFTAKKTMMIAQQLYEGVELGSEGPTGLITYMRTDSTRISDTARKDARDFIQKNYGKEYLGNTNRTNKSKNNNVQDAHEAIRPTSVNRTPDDVKKFLTPDQYKLYKLIWERFLASQMADAIFEKTVIDIEVGKYLFRAVGKILVFPGFMKLYTETVEDAEDEDQQILPSVNINDTAIPNRYDTKQNFTTPPPRYTEASLVRVLEQKGIGRPSTYANIISTIQERGYVELKEKRFYPTELGRFVVKLLIDNFDQIFEVGFTAEMEKKLDEIEEGKLDWLELLNDFYRSFKHELEKADRQFVTNLKTDILCPQCKKGYLNIKFGKNGFFLACEHYPECNFTSNFTRDEQGRIVLTENKGGFEETDILCDKCGTRMVVKRSRFGEILTCPRYPECKNIKNFLRDKDGKIIVIDNGYVLDEKCPECGGELQLKKGKNGLFIGCKNYPKCTFTSNYTINEEGKVAIKPKSTVEEFQCEKCGGQMVLKRSRRGIFYACSNYPECKNTISAVKKEDGSISPKK
(516) DNA topoisomerase 1 [Aquifex aeolicus VF5]
1
MELFIVESPTKAKTIQKFLGKGFLVKATLGHVKDLPEKELGVDLRTLKAKYVYKRGKKKLVEQLKKLSRRSSIVYLGTDPDREGEAIAYFLKKDLEKVNKNIKRAVFYEITPEAIRESIRNAGDVNMNLVYAQFARRILDRLIGYLISPILWKEFKNYKLSAGRVQSPALRLIVEREREIQNFKVKKYYYVKALLRKGSEEFWAIYDYRYENPSDAKIIAKKLEKGYFSVYKVEKKKEKVSPPKPFITSDLQSEANAKFGFSSERTQKLAQELYEKGYITYPRTDSYRMNEKKAKEFMNYIEKKYGKEYVGRLRRFREKATAQGAHECIRPTSLREEIPEREELRLLYDLIFRRTIASLMKEMLLEREKVTVEAITPELKHPVYLVAKGLKIVFDGWSRVYPSEITEEKLPELYEGDLLDLVKTTLEERKTQPPPRYTEGTLIKTLEKLGIGRPSTYATIVKTLKERGYVEVKKKALVPTEIAFQVVEFLMERFPTLMDYKFTAQMEEKLDLVEEGKLNWKSVVYEFMEKIFGKELEMVR
(518) DNA topoisomerase 1 [Clostridium clariflavum DSM 19732]
1
MADKLVIVESPAKAHTISKFLGKDYKIIASVGHVRDLPKSQMGVDIENNFEPKYITIRGKGDVISKLKKEAKNAKKIYLATDPDREGEAISWHLAYLLNIDSKEKCRVTFNEITKNAVKNAMKEPREINLDLVNAQQARRILDRIVGYKISPILWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTIDAVLQKKDEKGSFNAKFYGKDGKKMELKSEDDVKRILENIKGKPFIVQKIKKGEKKKSPAPPFITSTMQQEAARKLGFSTKKTMIVAQQLYEGIDIKGVGALGLVTYIRTDSTRISDEAQQDVIQFIKEKYGEKYLPTEKRVFKNKNASQDAHECIRPSQVNMDPDSIKDSLTKDQYKLYKLIWSRFVSSQMASAEYDTISTDITIGDYTFKANGQMLKFPGFTVLYQESKDEEGEEKENDIPDLIEGEELKQKKIEPKQHFTQPPPRYTEASLVKTLEEKGIGRPSTYAPIITTILARGYVVKDGKTLMPTELGKIVNDIMKTYFQDIVDVEFTAQLEKKLDDIEEGYKKWVDVMQSFYSPFAKVLEEAEEKIGNVEVPDEVTDEICEKCGRNMVIKMSRFGKFLACPGFPECRNARPILEEAGVKCPKCGGKVYIKKSKKGKKYLGCENNPTCSFMSWDMPSKESCPKCGNFLLKKYLGKKVQLKCSNEECDFIKDGERKKEE
(521) DNA topoisomerase 1 [Streptococcus parauberis KCTC 11537]
1
MVTKTTSKAKTTSKKATSKKKTTSPKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPEYINIRGKGPLINSLKKEAKNAKQVFLASDPDREGEAISWHLSHILGLNLEDKNRVVFNEITKDAVKNAFIEPRQVDMNLVDSQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDSLFKKGTKKFQASFYGVDGKKVKLNTNEEVKDVLSRIKNDDFTVEKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMIAQNLYEGINLGSQGTQGLITYMRTDSTRISPSVQNEAATFISNRFGSKYSKHGSRIKNASGAQDAHEAIRPSNVNHTPESIAKHLNKDQLKLYTLIWNRFVASQMTAAIFDTVKVTLEQNKVTFVANGSQIKFDGYMAVYNDSDKNKMLPEMTESETVKRESSSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYYVKLAAKRFEPTELGEIVNKLIVEFFPNIVDVAFTASMEAELDQVEEGQVKWQTVIDHFYKPFSNDLVKAEDEIEKIQIKDEPAGFDCDLCGHPMVIKLGRFGKFYACSNFPDCRNTKAITKEIGVTCPICQKGQVIERKTKRNRIFYGCDRYPECDFTSWDIPVGRTCPKSGDYLVEKKIRGGGKQVVCSSETCDYKEEKVK
(525) DNA topoisomerase 1 [Helicobacter canadensis MIT 98-5491]
1
MSLKDLIIVESPTKAKTIKNFVGSNYEVIASKGHIRDLPKHSFGIKIDNQEFIPEYKIDESHKNIVSELKKLAKDSKTIYIATDEDREGEAIGFHIATAIGKDPQKLPRIVFHEITKKAILDSLKNPRHIDMDKVNAQQARRLLDRIVGYRLSPLIASKIQRGLSAGRVQSSALKIIVDREKEILNFKPITYYSIDIAFKEQLESELLEFKGKKIQKLSLQDKAEALEMIQQLKQESFKVKEIENKKRKTATPPPFMTSTLQQSASSILGFSPSRTMQTAQKLYEGVMTHKGSMGVITYMRTDSLNIAKIAQDEAREFITKTYGKEYAPSKPKNYATKAKGAQEAHEAIRPTLVDFTPQIAAQYLKGDELKLYTLIYNRFLASQMSDAEFELQNIFIDSNSSLLKISGRKLIFDGFYRILGNEDKDKLLPHLKVGEVLKLEKCDLSEHQTEPPARFSEASLIKTLESLGIGRPSTYAPTISLLNSREYISIEKKQIKPQEIAFKVVELLEKHFLEIVDSKFTANLEEKLDEIAENKQDWQKLLWEFYEPFIQKVNEGKTSIQSQKIALPTGENCPLCGKELIKRSGRFGEFVGCSGYPKCKYIKKEVEENAQEESYGVCEKCGKPMVKKRSRSGEFLACSGYPECKNTKSLNNSAPSAKKAVEGVKCPKCSGEILERMSRRGKFYGCANYPKCDFISTYEPTNVHCPKCNSLMAKRTYRKKAVLECIACKERIEEIQTTIKE
(526) DNA topoisomerase 1 [Thermodesulfovibrio yellowstonii DSM 11347]
1
MELKGKNLIIVESPAKAKTINKIVGKDFQVKASIGHIKDLPEDRLGVDIEKGFQPDYIIIPGKEKIVKELKDSAKNAQKIFIATDPDREGEAIAYHIAEEIKVPENKVYRAIFHEITPNAVKAAIANPSKIDINKVYSQQARRILDRLVGYNLSPFLWKKVKKGLSAGRVQSVALRMVVEREKEILIFQPENYWTIVGNFKNDENLKELRANLYKYKGKLIIDRKEEKAKFLITDEETAQKIIEELKKLNYILTKVEKKKKKKNPPEPFRTATLQAQASSTLGFSPKKTMMLAQQLYEGIDIEGTRIGLITYMRTDSTRVAEEAKKWAKNIIEKNFGKEFVGNHKIHETKKQKTPIQDAHECIRPTYPDKSPESIKKYLTKEQYSLYKLIWDRFLASQMSPAEVEQTTYIIEDLDSIAQFRVTGSVITFPGFLIIYKDEESEEDTVLPQLNEKTSLKISELEAQKHTTEPPPRYTEATLVKALEEKGIGRPSTYATILSTIQERGYVKKVKQKLQPTYLGFVVNDLLEEKFPELMDYSFTAKMEEDLDKISLNEAKWNKVIEEFYKEFENDLDQASKISKVIKPKEIKTSFKCEKCGKDMVIRWSKGVPFLACSGYPECKNTRSLNNNENGSTKKTLDKKCPQCGAQLVVRNGKRGEFIACSNYPKCKFTQSITAQVKCPQCGGDILKKQTKKGRTFWACANYPKCKFTLSNEPVPAECPKCKSSYMLKKKDRNGTEFLICHNKACKGKIEIKEHSTGTDPAQQKDANPARSGRKQR
(527) DNA topoisomerase 1 [Hippea maritima DSM 10411]
1
MNLVVVESPAKAKTISKFLGKNYSVVASYGHIRDLPKSSFGVDIEDGFKPKYVIPKDKQPIVRELKKLTKDSDLVYIATDEDREGEAIGWHITQATKLDETKLKRIAFHEITKKAILDAIKSPRSIDMDMVNSQEARRILDRIVGYKLSPLLAKKIRKGLSAGRVQSVALKLIVDREEEIQSFKPEEYWTIHLIFENSIQADLTKAYGEKFDKLFIKKEDDKARVSKLKEEIEKESFNVYSITKTKSLRKPEPPFITSTMQMAASTYLGFSAQRTMRIAQSLYEGVDIGKERIGLITYMRTDSVNIAKEALTKVRRTIKELLGDEYLPSKPVTYKTKSKLAQEAHEAIRPTDPALLPDMVKPYLTEDQFKLYDLIWRRFVASQMKPAEFRNTKITFTSYNFEAKASYKELVFDGFLRIWTFSKLNEDKIPILKKNQSVELTEVKPKQHFTEPPPRYTEASLIKELEKHGIGRPSTYATIIDTIIKRGYVVLKDKRFYPEEIGIITSRMLDKFFSDIINVKFTAQMEDGLDKIANRELTKLELLKRFYDKFKVLLENAYENMERIKPEDEPTDEVCPLCGANLVIRHGRFGKFLACSNYPKCKYTKPLQEEITEIKCDKCGAPMVVKYSRKGSKFLACSNYPKCKNTKPYPTGLKCSECGGDLIEYSSKRGRFYGCSNYPECKFTIKGELKNQKCPKCGYSLFVKKKDKWCCANKKCNYCE
(529) DNA topoisomerase 1 [Leuconostoc kimchii IMSNU 11154]
1
MVEPGKVAKKPAAKKTTKRKKSKNQKKLVVVESPAKAKTIEKYLGSTYKVVASLGHIRDLPKSTLGVDVDNDYDPKYINIRGKGDLIKGLRKEAKAAKVVYLASDPDREGEAISWHLQHILGLDPDQPNRVVFNEITKDAIKNAFKTPRKINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIAREREIQAFEPEEYWSLDSEFQKSRQKFKATFYGFDAKKQVLPDNDSVQSVLKNIDQSADFDVMKVNAKERKRNPQPAFTTATMQQTANTQLNFRTRKTMMAAQQLYEGINLGRGIGQIGLITYMRTDSTRISSVARHAAAVYIHDTWGEEYSQHKLVQGKLPEGAQDAHEAIRPSDVTITPSSIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNGVIFRANGSKTKFQGFTKAYPAAKEKDNALPDLAEGDRVKLANINPEQHFTLPPARYSEAALIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVENSFPDVTNMKFTARVEHELDEIETGDKQWVPVIDSFFKPFSKELEIAETTLEKVVMHDELAGMDCDICGAPMLVKMGRYGKFHACSRFPDCRHTQTIVKEIGLICPKCGKGQIIERKTKRQRTFYGCSRYPDCDFVSWEKPTEKTLPDGTTPKDDEMSDGQQNSQQPTDNKEEAT
(530) DNA topoisomerase 1 [Porphyromonas gingivalis TDC60]
1
MKNLVIVESPAKAKTIGRFLGSDYTVLSSYGHIRDLKPNKFSVDIQNNYEPEYEIPADKRPVVKELKSQADRSDFIWLASDEDREGEAIAWHLYEALGLKNKQTKRIVFHEITETAIRAAIENPRDIDINLVDAQQARRVLDRIVGFELSPVLWRRIRPSLSAGRVQSVALRLIVEREREINAFVPEASFRCTIEFVLPDGRMLTAELQKRFKTKEEARYFLEQCMDAHFHITDVAKRPGKRSPATPFTTSTLQQEAARKLGYGVAQTMRIAQKLYEEGLITYMRTDSVNLSDMALGALKKEITEHWGEQYYRFRRYKTKTKGAQEAHEAIRPTYIHRAEIDGTPQEQKLYQLIRRRTIASQMADAILEKTTITIGTDKFAETLSSQGEVIVFDGFLGVYREDSDEEHGSANTEEQLLPSVKAGDTLSLHHAKATESFTQRPARYTEASLVRKMEELGIGRPSTYAPTIQTIQNREYVVRGDKPGKTREYILLEYHKGKAITETIKTELNGQDRNKLLPTDMGLVVNDFLVASFPQVIDYNFTAKVEKEFDQIAEGKLQWQKQIGRFYNKFHPLVAEACEFDPDQKIGERMLGTDPVTGESVVAKMGRYGAMVQKGHTDKENGIKAQFASLQPGQSIESITLEEALELFLLPKKLGQYEDADVMVAVGRFGPYIKHAGKFVGLPKDTDPLSVSLDDAIKYIVDKREKEEKSLIKGFAEDPEMEIRRGRFGVYIKYKGKNYKVPKTVEDPEKLTLEECLKYVEEGETKPAKGKKKAPAKKTSAKKTAKK
(532) DNA topoisomerase 1 [Flavobacterium columnare ATCC 49512]
1
MAKNLVIVESPAKAKTIEKFLGKDFQVESSFGHIADLPSKEMGVDVENRFKPKYEVSSDKKALVKKLKDLSKTAEMVWLASDEDREGEAIAWHLAEELKLDRSKTKRIVFHEITKTAIQKAIENPRGINYDLVNAQQARRVLDRLVGYELSPVLWKKVKSGLSAGRVQSVSVRLIVEREREIQNFTSEATYSVSAEFSNELGRTFRTKLTKNFTTKEEAEKFLQQNIGSIYKVSDLETKPTKKSPAAPFTTSTLQQEAARKLYMPVGITMQVAQRLYEAGLITYMRTDSVNLSQEAMSAAQDEISNYYGKEFSQPRSYATKSKGAQEAHEAIRPTDMSRHTVQLDRDQSRLYDLIWKRTIASQMSDAQLERTNVKIEANNHKEIFGATGEVIKFEGFLKVYLEGNDDEDEKEEGMLPALKINEILKNNYITATERFSRPAARYTEASLVKKLEELGIGRPSTYAPTISTIINRNYVEKGNFEGAERKYNQLILKNNQIKSEILSENVGSDKGKLVPTDIGTIVNDFLVKNFETILDYNFTAKVEQDFDEIAIGNKEWENMMDDFYKHFHPNVQNVEKNAERESGERILGVDPKTGKQVLVRLGKFGPMVQIGNADDEAKQFASLRAEQNIGTVTLEEALDLFLLPKMLGEYNGEEVEVNNGRFGPYVRLGKIFISLPKGEDPLDVTLDRAKELIDEKNKADAPIGQYQGMDVQKGVGRFGPFIKWNGMFINVNKKYNFDQLSSSDITELIEDKLQKESEKLIHNWEVEGIRVEKARWGRSVILKGKIKIELSKDVDAAQLTLEKVQEMIEAKAPAKKTPAKKTTPKKTTIKKK
(533) DNA topoisomerase 1 [Bacillus anthracis str. CDC 684]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(534) DNA topoisomerase 1 [Anaplasma phagocytophilum str. HZ]
1
MGVVIVESPSKAKTISKYLGKKFNVIASFGHIRDFPAKSGSVDPSNDFKMIYEIIPKSEKHLDKIVKTVSAEKEAIYLATDPDREGEAIAWHIVEVLKEKCAIAKDVTVNRMVFNEVTKRAVTAAVDNCRPINMDLVRAQQTRRVLDYLVGFTLSPLLWRKLPGSRSAGRVQSVALRLLCEREYEVEQFKTQEYWDVGVDLQNQGGEKFEAVLKCYAGEKLEKFSIGTEEQAKEYAETVKNQSYTVESVESKKTKRNPYPPFITSSLQQEASTKLGFSAKNTMMIAQKLYEGIDIGGEIVGLITYMRTDGFYISEDAVNYIRDTIKMQFGEKYLSKSVRNYTKKVKNAQEAHEAIRPTDITMLPEQLSKYLTDEQLKLYTLIWKRTLATQMESAVIDQVAVDIKSSCGKISLHATGSTLSFDGYYRVYGSEDSDKRRMLPQLREGESCELLEVHPNQHFTQPPARYSEASLVKKMEEIGIGRPSTYATIISVLQERGYTQLEQKRFIPSERGRIVNAFLTNFFRKYVEYDFTANLEEELDLISNGKMVWKEVLSQFWDKFISDVSSVKTIEASEILKAITRDLENYAFSSVDGESISRVCPQCGSGELMLNIGKTSAFLGCNRYPECRYTRGIGGDGSASPADDASRILGIDEETQEEIFLKRGPYGEYLQLGNSTKRVSLTKSAGEITVDLAKKMLSLPLVLGCYPDTDKEIKLGIGRFGPYLFYNGVYFSIKDREDYINISHQEAVEIIDKQSDKKAKLLGQNKDGKDIYVCKGRYGFYLKCDKTSVALKGRSEDITLEDAILLLSQKQ
(535) DNA topoisomerase 1 [Alkalilimnicola ehrlichii MLHE-1]
1
MSKNLVIVESPAKAKTINKYLGKDYKVLASYGHVRDLVPKEGAVDPEHGFAMKYTTIDKNAKHVDTIAKAMKQADALYLATDPDREGEAISWHLYELLKEKGALKDKPVYRVVFHEITPRAIREAMEHPRELSTPLINAQQARRALDYLVGFNLSPLLWKKIATGLSAGRVQSPALRMIVEREEEIEKFISREYWTVEADLARNGEAFPGRLHTLDGQRVKQFDIDNGERAREVEHQLARAAGMALSKSHIDAGEGESPVQSPGTVQVTQVEKKQRRRNPAAPFTTSTLQQEAARKLGFTANRTMRVAQQLYEGIDIGGGVTGLITYMRTDSVNLSQEAVADLRDTIAKRYGEDRLPKAPQVYRTKSKNAQEAHEAIRPTGAFRLPEEVRGKLSDDQFRLYELIWKRAVACQMIPALINTVAVDLACGEGNSFRATGSTIAEPGFMAVYLEGTDDRKPDVGSSERILPPLKEGDKVALERIKPEQHFTEPPPRYTEASLVRALEEYGIGRPSTYAAIISTLQQRKYVELDGKRFRPTDIGRVVNRFLTDHFDRYVDYDFTARLEDDLDAVSRGERDWVPLLEEFWQPFKDKVDEKATISREEVMQSRDLGTDPKTGKPVSVRVGRFGPFVQLGTKDDEEKPRFAGLRPGQSMDKITLEEALELFKLPRDMGETPEGEPMQVNIGRFGPYVRFGNKFVSIKDDDPYTISRERCLELVEEKKRIERERTIRDFEGSDIRILKGRYGPYITNGKKNARIPKDREPESLGLEECEELIAKAPERKGRRRTGGTGRKRSTKA
(540) DNA topoisomerase 1 [Beijerinckia indica subsp. indica ATCC 9039]
1
MNVVIVESPAKAKTINKYLGKDYEVFASFGHVRDLPPKDGSVDPDHDFAMLWDVDTKSAKRLADIAKAVKEADRVILATDPDREGEAISWHVLEVLKAKKVLKDKPVERVVFNAITQSAILDAMRHPRAIDIDLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCERELEIERFVPREYWSLTAFLRTPADQPFSAKLVGADGKKINRLDIGAGAEAEAFKAALETAKFTVAKVEAKPARRNPAPPFTTSTLQQEAARKLGLAPARTMQLAQRLYEGIDLDGETVGLITYMRTDGVDLAPEAITGARKVIAAEYGDKYVPQAPRRYQVKAKNAQEAHEAIRPTDLARLPKHVARFLDAEQARLYDLIWTRTIASQMESAELERTTVDILAEVGARRLDLRATGQVVRFDGFLKLYQEGRDDEEDEEGGRLPAMQVGDPLKKDRIEASQHFTEPPPRFTEATLVKRMEELGIGRPSTYASTLAVLKDREYVRIDKKRLIPEDKGRLVTAFLESFFGRYVGYDFTADLESSLDKISNHEIDWKQVLRDFWADFSGAIADTKDLRTTQVLDSLNEVLGPYIFPDKGDGSNPRACPSCANGQLSLKLGKFGSFIGCSNYPECKFTRTLSDTGPEGGNGETDRPGVKVLGVDAETGEEISLRDGRFGAYVQRGEGEKPKRASLPKTIAPADLTLDMALGLLSLPREVARHPETHEPILAGIGRFGPYVQHGKTYANIGKDEDILTLGANRAIDLIIAKESGLTGRRFGKGESAPARVLGDHPEGGQVTIKAGRFGPYVNYGKLNATLPKDADPTTLTLEEGLALLAAKASGQGGGKGAVQGQLLGEHPSGGPITVREGRFGPYVNHGKVNATLKSGLSPETLTLEEAIRLIDEKAGAASKKAPAKKAPAKKASGKTTTTEKAPAKKAASKAATAKTTKAKAAKSSEPDEEPPF
(545) DNA topoisomerase 1 [Lactobacillus gasseri ATCC 33323]
1
MPTKRKNKKNLVIVESPHKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGVDVEHDYEPKYISIRGKGDTIKELKSEAKKAKYVYLASDPDREGEAIAWHVAHALNLDPKEHNRVAFNEITKDAVKNAFKNPRTIDMDIVDAQQARRVLDRLVGYSISPILWQKVKKGLSAGRVQSIALKLVIDRENEIKNFKPEEYWTIDADFEKGKEKFKGAFYGIKGKKQDLPNNEAVQDILKQIDKRKNFEVTKVVKKERRRQPAAPFTTSTMQQEANKRLGYRTRRTMRIAQSLYEGVNLGKGSVGLITYMRTDSKRIANVAKHEASKFIHEEYGANYAAIKPQHFKNDADAQDAHEAIRPTSAFRTPASVKEYLTTEEYRLYTLIWSRFIASQMTPAVYDTVRADIEQNDVTFRTTGSKLKFAGFTKVYDNQKEKNNELPELNEGDKVKLKKTDDRQHFTQPPARYTEASLVRALEENGVGRPSTYAPTIDTIQKRYYVKLEGRSIVPTELGEIVDKLIEEFFPDIVNVDFTAQLEDDLDGVEVGKKNWIKVVDEYYKPFSKELDKADQQIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKVGVTCPKCGKGEVIEKKSKRNRKFYGCSRYPDCDFVSWDQPIGRNCPNDGHFLVQKKNKKGLVILCPNGDYREEPEEN
(546) DNA topoisomerase 1 [Halanaerobium hydrogeniformans]
1
MAKKNKNLVIVESPAKAKTIAKFLGRNYKVKASMGHVIDLPKSKMGIDIENNFEPNYITIRGKGKTLAKLRKEAKKSNEVYLATDPDREGEAISWHLSHALKLSEEDNNRIEFNEITKNAIKNAIKKPRQIDKNLVDAQQARRLLDRLVGYRLSPLLWKKVRKGLSAGRVQTIAVKLICEREEEIRNFEEEEYWTIDVDLKKDKDKLTASLYRIDNKKYNIDSEEAANKIVSDIKKEDFEIIKVKKRKRRRNPKSAFTTSTLQQTASSKLNYSAKKTMYLAQQLYEGMDIGSSGSVGLISYIRTDSTRLSEEAKAGAAKYIEAEFGDKFLRSKKKKKKKNKNSQDAHEAIRPTDTMRTPDKMKKHLSKDQYKLYDLIWRRFVASQMSPALYESISAQFKAGEKYKFRVSGSRLLFPGHLILTGKAKEDKIDLPVLKEGDVYKLQDVKPEQHFTKPPARFSEASLVKTLEEEGIGRPSTYAPTLSTIVSRDYVEKDGRYLKPTELGETVTELLSEYFPDVTDVEFTASLEQRLDEIEKGNEDWKKLLKDFYQPFYERLEHARENMERVQIVEETDEVCEVCGKPMVVKYGRYGKFLACSGYPDCKNTKPYLIKTGVDCPECDDGEVIERTSKKGRTFFGCSNYPECNFMAWNKPVEKPCPECGGVMVEKTTKAKGEHYKCINKECGHTEKAE
(547) DNA topoisomerase 1 [Salinibacter ruber DSM 13855]
1
MKRLVVVESPTKARTIREFLPETGYRVEASMGHIRDLPASADQIPSEYKDEDWSRLGVKVTNGFEPLYVVPPDKKEVVRDLKQAVSDADRLYIATDEDREGESIGWHLIHTLDPDVPVERMVFHEITEDAIQRALDDTRDIDQHLVEAQQTRRILDRLVGYSISPLLWRKIKPKLSAGRVQSVAVRLLVQKERERITFVPATYWDLDAQLAKQGIGVEAEMTHLNEVRLASGKDFDEDTGRLKESLTEGEDVVLLDEEQATALAEGLPETRWRIDDIKERTRTKSPFPPFITSTLQQEANRKLNLSSSRTMSVAQSLYENGYITYMRTDSTNLSSEAVEGARRTVAQRYGDEYLSDGVRQYSSSDSAQEAHEAIRPAGSEMKTKDELGLSGIEAALYDLIWKRMLATQTADAKVRYTNVYFDAEVDGDVARFRASGKRLDFPGFFRVLVEGSEDPEAALRDQERPLPPLEVGETAAQSADDDGFQVRSVEPLGHETKPPSRYTEASLVETLEEEGIGRPSTYASIIGTIQQRGYVRKKGSALVPTFTAFATNNLMETQFEPLVDVHFTAEMEDVLDDIARGRKDPTPYLRDFYKGEEGVETRVEQGLDDIDPKQISEMSFPDQWGEYVVRVGKYGAYVEGEMDGATVTASIPDDLAPGDTTEERLREILEEANRGDRVLGIHPEASLPVLLKSGPYGPYVQLGDDEEEDDPKRVSLPPDVEPEDVDFDLGVRIVDLPRTLGEHPDTGKEIEADIGRYGPYVRHEGTFASLQKGDDVLEVGLERALELIRRKEARNEPDRVLGPHPGSDEPVEVWNGRYGPYVKHDGTNASLKDDQSIDDVTMDDALDLLAEKGDEATQKVRE
(552) DNA topoisomerase 1 [Butyrivibrio proteoclasticus B316]
1
MASKTTTTKKNSLLIVESPTKVKAIKKFLGNGYDVAASNGHVRDLPKSQMGVDVEHDFEPKYITIRGKGDVLADLRKKVKKADHVYLATDPDREGEAISWHLIAALKLDEADAKIQRVTFNEITKNAVKEAMKHPRDIDMNLVDAQQARRVLDRMVGYSISPLLWSKIKRGLSAGRVQSVALRIIADREEEIESFIPSEYWTLDVNLAAEGEKKPLVAHYYGTGNDKKEIKSKEELDKICASLKGAKYVVSDVKKGERNKKAPLPFTTSTLQQEASKALNFSTQKTMRVAQQLYEGIELGKQGTVGLITYLRTDSTRVSDEAVAAANAYISSNFGDKYLSEGTTAKKSDAKIQDAHEAIRPTYVENTPVVVKEFLSRDQFRLYQLIWRRFMASRMAPAKYETTSVKIDAGEHRFTVAASKTVFDGFLNVYTDEDDQIEKNVLMKNLDINTKLSFDSFDSAQHFTQPAPHYTEASLVHDLEALGIGRPSTYAPTISTILARHYITKENKAIFITELGQAVNKMMNDAFPQIVDVNFTSNMEALLDGIADGNVKWKTVVENFYPDLNEAVEAAEKEMEKIQVQDEVTDEICPNCGRNMVIKYGPHGKFLACPGFPECKNTMPYFEKIGVECPKCGKDLVLKRTRKGRIYYGCIGSPECDFMSWARPVKEKCPKCGKYMVAKSNKLACSDQECGFSCNKDELKKE
(553) DNA topoisomerase 1 [Desulfomicrobium baculatum DSM 4028]
1
MGKDLIIVESPAKIKTIKKFLGGGYEVEASVGHVRDLPTKTLGVDEGNDFAPDYQIIPGKAKVVSKLKSAAKAADTVYLAPDPDREGEAIAWHVAEVIRTSNPNVKRIQFNEITAKAVKEALANPTELRKPLFDSQQARRILDRLVGYKISPLLWKKVKRGLSAGRVQSVALRLIVDRERERQAFVSEEYWVFKITVQGETPPPFDADLWKVDGEKPVIGDEKTALALESRVDGQSYVVRDIVEKERQRHPRPPFITSTLQQDASNKLGFNAKRTMSVAQRLYEGVELGERGTTALITYMRTDSVRISDEAKDGAREWITRTLGPEFYPKEPRVYKSKGSAQDAHEAIRPVDPSLTPDSIKNNLPPEQYKLYRLIWERFMASQMASARFWDTVATIESGPAQWRAKGERLVFPGFLQIWPQSSDNQSALLPKLVTGQELRLEKLHKEQKFTQPPARFSEASLVHKLEELGIGRPSTYAAIISTLTERDYVHIEEKHFQPTDLGVIVCDLLVEHFAHLMDAGFTARMEESLDHVAEGETDWVALLRDFTLDFNPTLDKARENMTQVKAGMDTGLSCPQCEDGRLVVKFGKNGTFLGCANYPACSFTSNYIRNNAGEIELVKEEAPEELGPCPKCEDGRLVVKKTKTGGRFVACSNYPACRHTKSVSTGVACPKDGCDGELVEKTSRRGKPFYSCSKYPKCDYAVWDFPVAKPCPLCESKILVRKETKARGAHLACPVKDCGYWEKLD
(554) DNA topoisomerase 1 [Jannaschia sp. CCS1]
1
MPVVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPSKDGSVDPEEGFFMKWEIGSDSKKHVKAIVDALKDDNSLILATDPDREGEAISWHLQEALTSRKAIKTDTPVSRVTFNAITKDAVTKAMAEPRQVDMELVEAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVCLRLVVEREMEIEAFRPREYWSVRAVLETPRGQTIEARLTVLGGKKLDRYDLPSAAEAGLAVQAVSSRKLSVSDVEAKPANRNPSPPFMTSTLQQEASRKLGMGAKQAMSTAQRLYEAGHITYMRTDGIDMAPEAVEDARGAIKTRYGVDYVPGKPRIYKNKAKNAQEAHECVRPTDMSKAANDLKLSEDDQRKLYDLIWKRTIASQMEAARLERTTVTIASDDREVELRATGQVMLFDGFLKVYEEGRDDAGDDEDSKRLPQVSAGDPLKPSADAMADDYAKYSGDDVVEDDGNGDVRRSKSAILSREGAVLGQQHHTAPPPRYTEATLVKRMEELGIGRPSTYASIMDTIQNRGYVIKDKGRLIPEDKGRLVTVFLSNYFNRYVQYDFTADLEQQLDEVSAGDRHYKDVLDRFWRDFRAAIDETSDLRIGEVLDKINEVLEPHLFPDPGDGTDPRLCPNCGVGRLSMRTARAGGAFIGCSAYPECRYTRPFGPPDPEAEASAIPPDGKLLGEDQGDEIRIFKGRFGPYVQRGAMTEENKKPPRQSIPKDWTPEELDLERALMLLSLPRQIGPHPEDGIMVWSNIGRYGPYLKHAESTSDRGGTNANLDGLDEVFTVGMNRAVQLLAEKVASRGGRGQAAKPLRELGEHPDAGGPVNVMKGKYGPYVKWDKVNATIPEAIDPEAITMDQAVQLIEERAAKSGKKKPAAKKKTTAKKPAAKKKPAAKKTAKSAD
(558) DNA topoisomerase 1 [Bacillus thuringiensis serovar konkukian str. 97-27]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEIEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(560) DNA topoisomerase 1 [Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2]
1
MQKNLVIVESPAKAKTIEKFLGSDYKVLPSYGHIRDLKNKGLSIDINNDFKPEYVISPDKVEVVKQLRKATKAVETVWLASDEDREGEAIAWHLYIVLGLQESNSRRIVFHEITKNAILNAIEHPRHIDLRLVNAQQARRVLDRIVGFELSPILWKKIMPSLSAGRVQSVAVRLIVEREREINNFITESFFRIRALFYLPNNKIIVQSELNKHFKTEEGAKAFLETLKDAIFTIDDINIRSSKKSPTPPFITSTLQQEAANKAGFSISQTMSIAQKLYDSGLITYMRTDSLNLSSLALNDVQKEIIDKFGDRYVKIRQYQTKIKGAQEAHEAIRPTYISNRMVAGTVQEQRLYQLIWERTIASQMADAELEKTMVTIGISNNAIDKFHLQGEVVKFDGFFRAHTESIDSKNAEAVLPPMQLNEILNLTEATASEHLTRQPLRYTEASLVRKLEKLGIGRPSTYAPIISTIQQRGYVIKGAKEGKQKLFTTLTLKNKIVSKQTKTEIVGADKNKLIPSDSGIIVNDFLIEHFPIVLEYNFTADLEKEFDKIAEGQIGWIELLHKFYNLFHPIVEKVSFTQIGCKVGERILGTDKNGKLISVKIGRFGSFVQIGSAEDEEKPQFASLVQGQSIESITLEEALALFDLPRTVGIVANKPVIVTIGRFGPYMKFDNAFISIPKEYDPYHITIEEAEKLIKEKKERDANKIIKFFSENNDLKVLNGRFGAYIAYKKNNYKIPRGIVPEIISYDDAMEIIEKNPKRKRGNIFLSRGKKS
(565) DNA topoisomerase 1 [Borrelia bissettii DN127]
1
MENKKLIIVESPTKAKTIKKFLDESFLVEACIGHIVDLPNNAKEIPKEYKKYEWANISIDYNNGFNPIYIIPSNKRPIVSKLKKLVKTINEIYLATDQDREGETIAFHLKEVLKIKNYKRMIFHEITETAITESLKNTRNIDMNLVNAGEARRILDRLYGYTISPLLWKKVAYGLSAGRVQSVGLKLLIEKEKTRINFKKANYYSILLQCKHEKKDLLLETKLEEIEGKNIAEGKDFINETGKLKNITKTIIITQDLMVELEKELKNGQKIELISIETKKIKIPPPKPFTTSTLQQEINKHLKIGTKQIMQHAQKLYEHGYITYMRTDSHNIAKIAKDKITKIIKNKYGKDYVEEKDRIYEKEKMAQNAHEAIRPSEMFIPNETIEIESKTAKEIYKIIWDRTIISGMKDAIKENIKLTFKYKNLIFRSSFTKIIFDGFLKHTKEKDECLNINFDLIKKGDTFSIVKMKPNEHETKAPFRYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNTLMPTIKGAAVINLLEKYFPVLIELNFTSNMEEKLDKIAVGKLDKIKYLSKFYNGKKGLKDTVMQLEPKIDSSEFRTVIESQDIENKNDNSINYTINIGKYGPYLIFKGHNYSINTKTPLENLYKKDEIEKIINEKELKPNILGIDPLTGLNVIFKNTIYGNIVQLGEDTYAPQEYTKKGKPKKLKIIKAKKASTKKIDPENITLELALKLLSLPKPIGKHPQTNEQIIAATGVFGDYIKTESGSIACSLKKDLKAYDITLDKAISLLNERANKVGIIVKIITFSKNKIGNKIYIYKKNDTFYAKIKRKKIDLPDNINLDEVNEKYVFSLL
(566) DNA topoisomerase 1 [Novosphingobium aromaticivorans DSM 12444]
1
MQLVIVESPAKAKTIEKYLGPGYKVLASYGHVRDLPVKDGSVRPDEDFAMDWELYGDKQARVKAISDAAKGADRLILATDPDREGEAISWHVRELLAKRRVLPKEVERVTFNAITKQTVTDAMKKPRALDQDLIDAYLARRALDYLFGFTLSPVLWRKLPGAKSAGRVQSVALRLIVEREREIEAFRAQEYWSVIARLEHAGTEFAARLVKFDGQKLDKLTLGDEGAAMRAKGVVEAATFRVEEVETKPTRRNPYPPFTTSTLQQEAARKLGFSASHTMRVAQTLYEAGAITYMRTDGVQMDPSAISAARKAISDRYDGHYLPEKPRHYETKAKNAQEAHEAIRPTDFSKDRYGSADEARLYDLIYKRAMASQMASANIERTTVTLRDGTGKHELRATGQVVKFPGFLAVYEEGRDQKQDGDEEDGSLLPAMASGDTPAKRGVDATQHFTQPPPRYSEASLVKRLEELGIGRPSTYAATLQVLKDRNYVRTEKNRFFAEESGRLLTAFLERFFPRYVAYEFTAGMEEELDDVSGGRAEWKKVLADFWRDFKPKSDEVMEKKPSEVTAELDEFLSDYLFPPRADGTDPRLCPKCEEGRLSLRGGRYGAFVACSNYPECKYTRKFAQPGGADGDGGEDGALGKDPETGLEVVRKAGRFGPYIQLGDGKEAKRASIPKDIGELDLEWALKLLSLPREVGVHPETGNPITASIGRYGPYLAHDGKYARLKSTAEVFETGMNAAVMLLAAAAAGAGARGSRAAAEPLKVFGAHPTSGGEIKLMAGRYGPYVTDGTTNATLPRDKQPEALTLEEAITLIDERAAKGPAKGKKKAPAKKASAAKKPPAAKKAPAKKAAPKKAAAAE
(567) DNA topoisomerase 1 [Exiguobacterium sibiricum 255-15]
1
MAKYLVIVESPAKAKTIKRYLGSNYTVKASMGHVIDLPKSQMGVDVEHDYEPKYITIRGKGPVLKELKTAAKKAQKIYLAADPDREGEAIAWHLAKALGVDESTECRVVFNEITKDAIKDSFKRPRKINYDLVDAQQARRILDRLVGYSMSPLLWKKIKKGLSAGRVQSVAVKMIIDREQEINAFLPEEYWTIKLELDANGEKLEANFYGIDGKKRELHSEEEVNEVLAKLSKSFTVDSVTKKERRRNPALPFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIELGKEGTVGLITYMRTDSTRTSETANLEAHGFIENAYGKEYIAVEKRKEKKAANSQDAHEAVRPTSTMRDPQLVKSYLSRDQFRLYKLIWERFVASQMAPAVLDTVKVDLVSNDVMFRANGSTVKFAGFMKVYIEDTDDETVTDVKDGLLPALEDGEVLEQEMIEPKQHFTQPPPRYTEARLVRAMEELGIGRPSTYAPTLDTIQKRGYVTLEEKKFLPTELGELVIDMISDYFQEFITVQFTADMEALLDAIEKGDMQWTEVVDPIYKSFEKRLTRAEAEIEKIEIKDEPAGEDCEVCGHAMVIKMGRYGKFMACSNFPECRNTKPIQVEIGVKCPTCGTGEIVERRSKKGRLFYGCSNYPECEFVSWDKPVEEPCPVCSSMMVQKKIKNGVKVECTSCGHHETRIDQEQEEE
(570) DNA topoisomerase 1 [Muricauda ruestringensis DSM 13258]
1
MPKNLVIVESPAKAKTIERFLGKEFQVESSFGHIADLPSKELGVDVENDFKPKYTVDKEKKALVKKLKDLAKKAETIWLASDEDREGEAISWHLAEELGLDKNKTKRIVFNSITKSAIQKAIENPRDINYNLVNAQQARRVLDRLVGYELSPVLWKKIKPGLSAGRVQSVAVRLIVEREREIEGFTPEASFRIRAEFKTNEGNAFAAKLNKTFPTKEAAESFLKENIGADFSVSDLAKKPAKKSPAAPFTTSTLQQEASRKLYFSVSRTMQVAQRLYEAGLITYMRTDSVNLSNEALSAAKSAILDNYGEKYSQTRNFTGKSKGAQEAHEAIRPTDMKLQSPQLERDQAKLYELIWKRTLASQMSDAQLERTNVKIKASTHNEEFSANGEVVKFDGFLKVYLEGTDDEDGEEQEGMLPAMNVGEPLQNVFISATERFSRPPYRYSEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTVEGAQRKYVQLVLEDGKVSDSQLTETVGSEKGKIVPTDIGMIVNDFLVTHFTQILDYNFTAQVEEDFDEIASGDEDWQEMMKNFYKDFHPNVLKVEETAERASGERVLGTDPKSGRQVSVRLGRFGPMVQIGTVDDEEKPQFASLLPEQSIGTITFEEAMTLFELPRQLGVYEGEEVEANVGRYGPYVRFGKKFISLAKGESAFDVDMDRAIELIKEKQKADAPIATYEGKDVTKGKGRFGPFIKWDGMFINVNKKYDFDNLTEGDIAELIEAKKKKEAEKVVQEWPEEKIRIEKARWGRHNIIKGKVKVEISKDVDATKVTLEEAQALLEKKSPKKKAKTKAKAKK
(572) DNA topoisomerase 1 [Arcobacter sp. L]
1
MASMGHVRDLPKSSLGFDPSDNFKPKYMVTADKKKVISDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAILKALENPRDVDQHLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFVPEEYWKVKADFINPELKAELAKISAKTAKVDNEEQALNIESSLNQGIYKLASIEEKESIRNPAAPFTTSTLQQEASRKLGLSVKQTMVIAQQLYEGNVGNIPNHTGGLITYMRTDSLNLSTVATSAAKAVIEEEYGKEYSLSKPRVYKSTAKGAQEAHEAIRPVNLALKPSMIKEFVEPAQYKLYSLIWKRTLATQMAQAKIANTTYKIEAGRDKEFEFQSKGQRIIFAGFMKAYTEGSDNPEAALDSTEKILPNIKVGTVLELEKLESEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYVTKTEDKKLIPTQTGEIVNSFLVDHFSDIVDLGFTAKIEEEFDEIALGKIAWEQVMKDFYGNFKKTIDEKEESVHKEDYLQSREIGIDPKSGKPVSARVGRFGPFIQIGTKDDEEKPKFVAIPDNLNMDTITLDEALFLFTLPRVVGLDNSGDEIKANIGRFGPYLQVKTKFYSLKTDDPYTVDLNRALEIIKETDEAKEKSTIKTFDKEKIQILIGQYGPYIKQGRKNFKIPKSVEAKDLTLEQCLEIIAKDSKTKTSSTKKASTEKKASTEKKETKKKTTTAKKTTKKSADK
(578) DNA topoisomerase 1 [Lactobacillus brevis ATCC 367]
1
MPTKAKPKAKTKTRRKPQKKLVIVESPAKAKTIEKYLGRTYKVVPSLGHVRDLPKSSMGVDTENDYDPHYISIRGKGDVIKGLRSEAKKAKAVYLASDPDREGESIAWHLAHVLNLDVTDKNRVTFNEITKDAVKEAFKTPRSIDMNLVNAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSIALSLIIQREKEIKAFIPEEYWTIDGEFKKARHTFAASFYGLNGKKTGLKDNDAVQAVLSKLDKKGNFDITNVVRKERKRTPQPPFTTSSMQQDANRKLNFRTRKTMMAAQQLYEGINLGKEGTQGLITYMRTDSTRISNIAKHEASTFIHEKYGAEYAATKPIKGKLPEGAQDAHEAIRPTSVFRTPASLKERLTKDQFRLYQLIWNRFVASQMTNAIMDTMAVTLEQNGVTFRANGSKMKFEGFLKIYKDGKEKDNLLPDLEIGDQVKLAKTDPAQHFTQPPARYSEANLIKALEENGVGRPSTYAPTLDTIQRRYYVKLVGRRFEPTELGEIVDGIINDYFPDVVNVDFTADLEHELDGIEDGKQDWVKVIDSFYKPFSTEVAHAEDAIEKIQIRDEPAGFDCDIYGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKEIGVTCPVCHKGEVIERKSKKNRIFYGCSRYPDCDFVSWDKPVGRDCPKDGHYLVAKKIRGGSQIVCPNGDYEEAPQK
(579) DNA topoisomerase 1 [Leptospira interrogans serovar Lai str. 56601]
1
MSLLIIVESPSKAKTIAGYLGKEFRILATLGHVADLPKTTLGLDLKNRFEPEYVILPGKKKILSEIIKTAKQSQKVFLATDPDREGEFISAYIRDRLQKKSNVFRIRFTEVTKQAILNSLQNPDTINEFLVDAQKTRRIGDRLIGYFISPVLWKQIGPGLSAGRVQSVALKWICEREEEIRNFKIEIYYNILLHGTDQKGIVGIFSRTGDRIFSKEKADQILQNVQKEKEFRISEKKETLGKLFPPPPFQTASLQQEAFKKLRFSSKKTMSLSQRLYEGMDLGNGQRNGLITYMRTDSVRLSSEFVERARSWILSELGETFASPLERKIRKSAKKIQDAHEAIRVTDPFLTPKEIKKFLGKEEAALYDLIWKRTISSLLPAEEFIKIEYSIFAAGECFQLETKKTIFPGYKILNEADVKTNPSWEKGELFILQKVECEKKQTEPPSRYSEGTLVAKLEKQGIGRPSTYATVSETLLKRKYVYEEKKFFYPFSLGEKVNFFLQSSFGELFREKFTAELESDLDRIEKKEIDSNSILNRLWLDLQTQIQNSKFILFQKEWATVLQKKKETGWGICPVCRNGILQKKKSSRKKEFYQCNRFPDCEFVSYELPESLE
(581) DNA topoisomerase 1 [Listeria ivanovii subsp. ivanovii PAM 55]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLDLDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVNGKKKKLSTADDVKEVMSAIKGKSFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEAGNYIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSSMRSPQAVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVRTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFIPTELGEIVNEMIEEYFPEILDVKFTANMESELDEVEHGQVEWVKVIDEFYKQFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVYKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERACPKCNERALVEKKLKKGVQVQCTNCDYKESTQQ
(587) DNA topoisomerase 1 [Brucella microti CCM 4915]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(588) DNA topoisomerase 1 [Tropheryma whipplei str. Twist]
1
MKKLVIVESPTKVSSVGRYLGDGYVVMSSVGHIRDLPAPSGLTPDLKRSAHAQFAVNIENDFEPYYVVLENKKKVVEELQSALNNSDELLIATDGDREGEAIAWHLVQVLKPTVPVRRLVFHEITREAIAYALQHPRPIDENLVDAQEARRILDRLYGYELSPVLWKKVRPGLSAGRVQSPATRLLVDRERERINFKSAEYQAVTADFQVDSDVFSASLTLFGERKIATGRDFDNLANLKTDALVLDKNLTDRILEELKSKGALDVEAIDSKPYSRNPYAPFITSTLQQDAAHKLGFSAKRTMRTAQQLYEKGFITYMRTDSPRLSLQAISAARAQVELLYGREFLPDSPRTYGAKAKNAQEAHEAIRPTGEVFERPESIESVLSVDCMRLYDLIWRRTIASQMVSARGETVTLTLSARIPERSIFVLSGTVLHEKGFLKVYEGLQDLNSKLLPNLQVGDQVTLVDVRAVGHTTLPPPRYTEASLVKVLEELGLGRPSTYALILSTIQERGYAHLRNRMLVPDWLAFSVVNLLENFFSRLIDYDFTANLEDQLDEIALGSQNRSDWLRKFYFGDDNLPGLKEIISGAKDIDARAINSIPMVGATLRVGRYGPYLEVGDKRFSIPHDVYPDALTPEKIHELVNQPESPVRELGAHPETGKLVVLKSGRFGPYIEEVSDEKNVRRSSLFKNMDPEEVNLDVAVKLLEIPRVIGVNQENGEKVIACNGRFGPYIKCGKETRPLDSEDDILSVTLDEALAILSAPKVRRSRVLMEFPTDDPVTRRAVQIKSGRFGPYVTDGVTNATLDNTSWEDVTFDEAVSLLAEKRQRVDGDLDQETAEKIHV
(590) DNA topoisomerase 1 [Spirochaeta smaragdinae DSM 11293]
1
MDGKTLVIVESPTKARTIKRFLPKNFIVEASVGHVRDLPQSASDIPKELKKEEWGRLGIDIDNQFRPLYVIPRGKGKIIRELKKRIKEVDLVLLATDEDREGESISWHLTEVLQPKVPVKRMVFHEITKKAIERALENERAIDMDLVNAQETRRILDRLYGYTLSPLIWKKIAYGLSAGRVQSPGLRLIVQRERERISFVKSVYWDIKAELFPEDEKKSFEAKLESLDGSRIAGGKDFDPATGKLLPNKKNVVVVDEATARSLEKELADVRWAVSELSEKHSKTRPAPPFITSTLQQEGNRKLRMSARETMRTAQRLYEQGFITYMRTDSPTLSAEALQGARSAVQELYGKEYLSEAPRQYAAKSKGAQEAHEAIRPAGERFRHPDETALSGREKSLYTLIWKRTLASQMAEARKVSVTAKIDAGRTRFSATGTRIEFPGFIRVYVEGKDDPEAALDDKETFLPPLAEGQELSLKGLESLVHETKPPARFTEATLVRELESLGIGRPSTYATIINTLFERQYVRKQGNALVPTFTGFAVVQLLERHFQEMIEYSFTSDMEAALDQIAVGKRNRLEYLTSFYLGDSGLKARVEHREKAIKPEESRTIDLPHITEGIKVGKYGPYLVQHHDGEEVHASIPEDIAPADLREEEIQELIRAQKNGPEPLGSDPESGEPVYCLTGRYGPYVQLGEKSDDNPKPRRAAVPKGLKPSEVTLELAIQRLSLPRALGINPATGKEVLVNDGRFGPYVLHDGEFRSLKKDDDLFTIGLDRALEILAEPKRGRGGVSVLKDFGAIADGGRKVAVYDGKYGPYIKCGAKNIRLPDDKRETEAIEKLSSEEVLEIINTASKAKGKK
(599) DNA topoisomerase 1 [Flavobacteriaceae bacterium 3519-10]
1
MSKNLVIVESPAKAKTIQKYLGKDFEVKSSFGHIRDLPKKGMGIDLATFTPDYEVSADKKKLVTELKAAVKKADIIWLASDEDREGEAIAWHLAQELKLNKDNTRRIVFHEITKNAILKAIENPRKIDQNLVNAQQARRILDRIVGFEMSPVLWKKVKTGLSAGRVQSVAVRLVVERELEIRMFQPKSSFKVEGVFFNTNKQDISAKLKKDFAKEQEAEAFLQQAQDVEFKVLNVETKPGTRTASAPFTTSTLQQEASNRLGYGVTATMRVAQRLYEEGFITYMRTDSVNLSQEAITGAQAQIIAEFGEEYSKPRNYTTKSSSAQEAHEAIRPTDFGTKNVPDAQLNKLYQLIYKRTLASQMTNAKIEKTVIEIGNPKLPQHFEAQGEVIVFDGFLKVYGITKAEDDEEENNEKLLPKVSVGETLDFKKIDATEKFTRPPARYTEAGLVKKLEELGIGRPSTYAPTIQTIQNREYVDKREVLPQEREIIRMTLGREGLKKEVVNEKFGGDKNKFLPTDIGEVVNDFLTQNFAEILDYGFTAKVEQDFDEIASGDEKWKDVLQGFYKDFHPKIEHVEENADRANGERILGKDPKSGKNVLTRIGRFGPMVQIGEQDDEEQPIFASLMPSQNIATITLEEALELFKVPFDLQEYQGKPVMVGVGRFGPYVKWGDAFISIPRGEEALSITQERAEEIINEKQIADAPIATYKGEPVTKGTGRFGPFIKYQSLFINVPKRYDFDNLSQDDINELIEAKLTKEANRYIQQWESEKISIENGRWGPFVKFGKAMFKIPKNKKDEKFTPEELAEIPLEEVKKWITAQDKNAFKEKPKKAAAKKAPAKKAPAKKTVNKK
(605) DNA topoisomerase 1 [Treponema brennaborense DSM 12168]
1
MAESKTAAAKTSKKKAAKSTLVIVESPAKAKTIEKYLGPGYTVKASMGHLIDLPKSRLAIDVEHGFNPEYITVRGRAKLLKELQKDAKKADEVLLASDNDREGEAIAWHLKHSFDGKTNADIKRIVFNEITPQAITEAVKHPSDIDESKVNAQKARRVLDRLVGYNLSPLLWKKVKNGLSAGRVQSVALRLICEREVEVENFIPDEYWSLDADFVKGKSKFTAQLVQYKDKKPELPNEAAVQTIIDEIGAQSCEVVDIKATEKTVRPKPPFTTSKLQQTAANRLGFTSRKTMQIAQQLYEGVNIGSNRVGLITYMRTDSVRIAQTAIDEVRAWITEKFPAELPEKPIEYAVGKKAQDAHEGIRPTYVTYTPDSIKEHLTRDQQRLYAIIWERFVSSQMNNAKSRTTSVDIKAGDALFRISASKVVEKGFYKVIKTLSSKEDSTGTLPALKVGEKLETLKFYPEQHFTQGPARFTDASIVKTLEEKGIGRPSTYAPIISVLLDRYYVTRSNKQLVPTPLGRMINDILVESFPEVVNENFTAQIENELDEVEEDKVKWSNMLGEFFFPFRDKVNEVMATHESFKGMMDEPTDKICEKCGKPMVKKLGRFGFFLACSGFPECHNTRSIPLAHCPRPGCNGEIVARKTKGRGKEFYGCTNYPECDFISHFKPINAYCPKCGQFLVEKYDKKNGTYKSCINPDCDYLHSNDDAAEPAVPPGDEE
(606) DNA topoisomerase 1 [Thermocrinis albus DSM 14484]
1
MMRLFLVESPTKAKTIQKYLGKDWKVLASMGHIKDLPEDELGVDLKTLEPRYVFVRGKRKVWDQIKRTAQKCESIYIGTDPDREGEAIAYFLWNLLKPLGKKLYRVRFYEVSKEAITLSVQKPEDSPNMNLVRAQMARRVLDRLIGYLLSPKLWVYLKNNRLSVGRVQSPALRLIVERERQIRQFKKKKFYYIKAVFEKNGHTFHLIWDYRFEKPENAKPYLEKLKSVPFEVERVVRGKVKKEPPKPFHTANLQAVASQKLGVGVDKVQKLAQKLYEEGFITYPRTDSLRMDEKKAQEFMNYIKKTLGEEYVGTLRKFKEKPTSQGAHECIRPVSLDRSPTGGVEEKLFTLIMKRTLASLASPALLEKTDVVVVPLCEPRMEFKGQWQRILFDGWLRIEEEELDLQEPPPLSEGEILLPKKVTLEERRTEPPPRYTEATLVKTLEKLGIGRPSTYAQIVKTLKDRGYVTEEKGVLKPTPLGEQVLDFLEKYYPRLVDYKFTAYMEEELDSVEEGKDWKTAVRYLFRAVAPEEELPSSTS
(611) DNA topoisomerase 1 [Chlorobium luteolum DSM 273]
1
MASKAAALSARNRTLIVVESPSKAKTINKYLGDGYTVFASVGHIKDLPKKEIGLDFDNHYEPRYEIIPGKEKVVRQLKKLASEADGVLIATDPDREGEAIAWHIANEIGSTPKPVFRVMFNEITKSAILAAIDEPRQIDYRLVRSQQTRQGLDKIVGYRVSPFLWNVVMRGLSAGRVQSVALRLICEREVEINNFEVQEYWTIAADFITEGKETFRARLVKLEGKKPELSNQAEAEAAADLVQKGSYTLLDIAPRTQQRKPPLPFTTSLLQQAASNQLGFGSKKTMRLAQQLYEGIDLGEEGATGLITYMRTDSIRIGNEAAGQARSFIEHAFGKEYIGWGGAAKSSKNAQDAHEAVRPTAVGRRPEQLKSYLSADQFKLYDLIWKRFVAAMMAPAKIEQTRVDVGDPARDIMFRASGSRVLFPGFMRVFNDQEELEYEARKSTKDEGEKEQEVRLPKQLEKDGLLGLGEIDNRQSFTRPPARFSEATLVKELDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTMLGMDVSQILVANFPDLFNVDFTAEMEGELDKVAAGEDEYEKVLDSFYRPLETALSVRKEDPLIPQNRDAALCEKCGEGHMIVKWTQSGKFLGCSRYPKCRNIKPISTNREKPKDTGILCPSCGEGHMLLRNGRLGPFLACSSYPKCNTLLNLSKQRHVEPMKIPPVQTDLACPKCGSPMNLRVGKRGPWLGCSKFPKCRGRMAWNSLDEGVRAHWEAVMEEHRKAHPSVTLMMLDGTPAPMQMAVDDIIQMAEESGMVEIAVEAPEEAVAEKQD
(615) DNA topoisomerase 1 [Gloeobacter violaceus PCC 7421]
1
MSKSLVIVESPAKAKTISKILGKNFVVKASAGHIRDLPQKEMGVNVKNDFEPKYVIIPKKEEVVEELKGAARNADRVYLAPDPDREGEAIAWHLAQILDIPGDRLQRIEFHEITKQAIQNAVAHPRDIDINRVDAQQARRILDRLVGYKLSPLLWKKVQRGLSAGRVQSVAVRLLCDREKEIQAFVSEEYWTVHGRFRQSAQVEATPFSADLVRWSGKKPDLGNETAARAVVEVLTGAASRVDSVKTRERQKEPQPPFITSTLQREGASALGLTVKRTMAIAQQLYEGIDLGEEGPVGLITYMRTDSTRVAEEAQEAAREFILAAYGKSYYPSRRRQYGAKKGAQDAHECVRPTDINRPPDAIKKSLTPDQFKLYRLIWQRFTASQMTAATLETRTVEIAATPTAGRPDALFRVSVTRTIFDGYTRVYEEAREEAATGDEEAAGAAPVLEEGEALTLLTVDPKQHFTQPPARFSEATLVKALEEQGIGRPSTYAPTIGTIQERGYVNKDGRTLIPTDLGMKVNDQLVQHFPNIVDTEFTANMEAQLDEVEKGSQRWTQLLADFYGPFVETLKAADEEMKRVVIVTDHLCESCGRPLLNRYGRFGNFLGCSGYPECDFTHQLTRDNKPVPKDRPAEGISCNQCGHAPMLITYGRYGEYLKCPACGKSQPKSTGITCPKCSKGQIVERRSKMGKNFYGCDQYPDCDFVLWSRPIDKPACPECGSILLYKPRKRGDDMVACSACKFTAPAQEMVGEEEVERQAELLTG
(616) DNA topoisomerase 1 [Desulfitobacterium hafniense DCB-2]
1
MAKTLVIVESPAKAKSISKFLSNNYTVKASMGHLRDLPKSQMGVDVDNDFEPKYIAIRGRGDLIKELRAAAKTANKILLASDPDREGEAIAWHLGHLLGLDLAEKCRIEFHEITKPAITAAIKHPRQIDSSKVDAQQARRVLDRLVGYQLSPFLWRKVKKGLSAGRVQSVAVRLICDREEEIREFIPEEYWTLTASLKSEGGVFSAKLARKGEHRIAIASEEEMQKVLQELADQTYRVKDVRTKEKKKQPSPPFTTSSLQQEAHRKLNMSPKRTMMLAQQLYEGIELGKAGGIGLITYMRTDSVRISETAQEEAKEFIAEHYGADYYPPEPRQFKSKGRAQEAHEAIRPTSILRTPDSVKEFLSRDQLRLYRLVWERFLASQMSAAVLDTLTVEVEAGEYLFRANASTVRFPGYLAVYEDGQDENDDQEEGTLAANIQPDESLNVLQLQEKQHFTEPPPKYTEASLVRKMEEEGIGRPSTYAPTIETIQSRGYVAKEGKQLSPTELGEIVVSILKEYFPEIVDLEFTANMEKRLDDIEEGALPWKAVIRDFYGPFAESIEEADQVMGKVQIEDKVSEEICENCGRNMVIKMGRYGKFLACPGFPECRNTKPLLEEVGRPCPDCGNPLVIRRSKKGRKFYGCSTYPECEFVSWELPAPEPCPKCGGLMVVKTSKQGQKYVCTNSECRFDKQVEEQAE
(618) DNA topoisomerase 1 [Ruegeria pomeroyi DSS-3]
1
MPVVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPAKDGSVDPEHDFDMTWEVAADSRKHVKAIADALAEDNELILATDPDREGEAISWHLQEALTKRRSIKKGTAVSRVTFNAITKDAVTKAMQNPRQVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVCLRLIVEREMEIEAFKPVEYWSVKALLETPRGQVYEARLVTLAGNKLDKMDISNATQAELAVQAITSRALSIQSVEAKPAARNPSAPFMTSTLQQEASRKFGMGARHCMSAAQRLYEAGHITYMRTDGIDMAPEAVMATRDAIADRFGAEYVPDSPRMYKNKAKNAQEAHECIRPTDMRKDAAALKLKDEDQRRLYDLIWKRTIACQMAAARLERTTVEIGSADGQVGLRATGQVVLFDGFLRVYEEGRDDVENDEDKRLPQISMGEKAVFAKTSLADQFARATGDTPLTEGAKIAKEAILSENEAVLALQHHTQPPPRYTEATLVKRMEELGIGRPSTYASVITTIQDREYVRKDKNRLIPEEKGRIVTIFLLNFFRQYVGYEFTANLEEQLDDVSAGSRDYKDLLGRFWRDFSAAISETSELRISEVLDKLDEALAPQLYPPREDGSDPRICPKCGTGQLHLKTSRTGGFVGCGNYPECRYTRPISGDADDSAERLLGEDGGDEIWLKAGRFGPYVQRGEISEENKKPPRASLPRGWSAEDLDLEKALVLLSLPRQIGQHPEGGMISSNFGRFGPYLMHQLPDEAKPIYANLKDPSDVFEIGMNRAVELLAEKRANPRGRGRAAAKPLKELGEHPEHGGAVNVLDGRYGAYIKWDKVNATLPKDVEAADVTMEMAVALIAEKSTKKGTKKKAAPRKKTTKKAAEE
(619) DNA topoisomerase 1 [Sphingobium chlorophenolicum L-1]
1
MQLVIVESPAKAKTIEKYLGGDFHVLASYGHIRDLPAKDGSVDPDAGFAMQWENYGDKGKQLKAIADEAKKATRLILATDPDREGEAISWHVQEVLRAKKALPQKVDRVTFNAITKQAVTEAMAQPRALDEDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIESFVPQEYWSVAAEMEQGGQGFTARLVRWRGEKIERLTIGREGDAMAAKADVEAGRFTVEKVETKPVSRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQQLYEDGAITYMRTDGVQMDGSAISAARKAIAERYDGGYLPEKPRQYQTKAKNAQEAHEAIRPTEFYRDKVGSGDHARLYDLIFKRALASQMASARLERTTIDLVDGTGQHGLRATGQVVIFPGFLALYEEGRDDTEDDDSKLLPRMAEGDAPAKKKVTAEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASTLQVLKDRDYVRIEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEEELDDISGGRAQWQAVLEAFWRDFKPKTTEVMEQKPSDITAELDKFLEPMLFPPKADGSNPRACPMCGDGQLSLRGGRFGAFIACSNYPECKYTRKFGQPGGKDGAEDSGPEVLGKHPETGQDIVRKSGRFGPYIEMGEGKEAKRGSIPKDLPDGEMTLDWAVKLLSLPREIGLHPETGKPIVANIGRFGPYLLHDGKYGRLSSTAEIFEVGMNSAVAKLADAANRGGRGASSREPLKVLGKHPRTEAEIKLMAGRYGPYVTDGTTNATLPKTIEQDALTLEEAAQLIDARAAAAPAKKGKKAPAKKAAAKKPAAKKAPAKKKVAAE
(623) DNA topoisomerase 1 [Sinorhizobium medicae WSM419]
1
MSWRRYWRAWSPKQLFQRMSMNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKASDGLILATDPDREGEAISWHVLDLLRKKKVLGDKPVKRVVFNAITKKAVLDAMAQPRDIDASLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLPAKAIGNGEEANRLKTLLDGASYVVESVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGIDIGGETVGLITYMRTDGVQMAPEAIDAARQAIGSQFGERYLPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDQVRRFLDGDMLRLYDLVWKRGIASQMASAEIERTTAEIVADNAGKRAGLRATGSVIRFDGFIAAYTDMKEDGEQTDDGDEDGRLPEINARENLAKQKINASQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATVTTLIDRDYVEIDKRKLLPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDRISAGELNWKDVLRDFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRICQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSSGDAEAAASNEPQSLGKDPHTGEEITLRNGRFGPYVQRGDGKEAKRASLPKGWTPATIDHEKALALLSLPRDLGPHPETGKMISAGIGRYGPFVLHNGTYANLESVEDVFSIGLNRATSVLADKQSKGAGGAGGRTGAAAVKELGEHPDGGAITVRDGRYGPYVNWGKVNATLPRGKDPQSVTVEEALAFIAERAAKGGVTKGKTAKGKSAGRKQAGTKTAKAAGTATAEKPKRAAKTKTKSAAKAKKD
(624) DNA topoisomerase 1 [Pseudoxanthomonas suwonensis 11-1]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPERGFAMRYDLIEKNEKHVEAIAKAARSADDIWLATDPDREGEAISWHIAEILKERGLLDGKPLRRVVFTEITPRAIKEAMTQPRTIAGELVDAQQARRALDYLVGFNLSPVLWRKVQPGLSAGRVQSPALRMIVEREEEIEAFKAREYWSIGAELAHAAQPFSAKLVKLDGQKFEQFTITDGESAEAARLRIQQAAAGALHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVTLGEEGTVGLISYMRTDSVNLSQEAVAEIRDVIARDYGTASVPDKPNTYQTKSKNAQEAHEAIRPTSALRTPGSVARFLTDDERRLYELVWKRAVASQMVPATLNTVSVDLAAGSDHVFRASGTTVVFPGFLAVYEEGKDTKTAEDEDEGRKLPPLKPGERVPLDRIHADQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLLFRKYAEMEGRAFRPTDVGRAVSKFLSGHFTRYVDYDFTARLEDELDAVSRGEEEWVPLMERFWAPFKELVEDKKESLDRTDAGSSRSLGIDPKSGKEVSARIGRFGPMVQIGTVDDEEKPKFASLQPGQSIYSISLEDALKLFDMPRNLGESNGQQVSVGIGRFGPFAKRGSTYASLKKEDDPYKIDLARAVELIEEKEEIARNRIIKEFPGSDIQVLNGRFGPYISDGKLNGKIPKDREPSTLTLEEVQQLLAETGKPARRGFGAKKAVARKAATKTAASKEAAPKKALAKKAPAKKAAKKATRKAAAKKAPAKKAAARATADDAPPF
(631) DNA topoisomerase 1 [Planctomyces limnophilus DSM 3776]
1
MAAKQHKALVIVESPAKARKIGEYLGKDYIVLASMGHVRDLPSGAAEVPAELKKEQWATLGVNIDQQFEPVYVVPKDKKKTVKELKDALKTCSELILATDEDREGESIGWHLMKLLEPKVPVSRMVFSEITKDAIQKAIRNTRELDQNLVEAQETRRVVDRLYGYRLSPLLWKKVAPRLSAGRVQSVAVRVLVRREMERLAFRKGSYWDLKAALATASSARFDAALATVGGRRVAQGRDFDESTGRLKTDADVLLLDEAQSKALQTKLEESPDWVVSNVETRLQTRKPYPPFTTSTLQQEANRKLGLSARETMQIAQRLYENGFITYMRTDSVSLSQEAISASRACVTNRYGQEFLHPEVRQYTTKSKSAQEAHEAIRPAGVEMKTAEELSLNGREGALYAMIWKRTVATQMAEAQLRFQTVTIGTLDVEFRATGRHVEFAGFFRAYVEGSDDPEGALEDSEAALPPMEKGQKLTCKEVQALAHETKPPARYTEATLVKTLEEEGIGRPSTYASIIGTIQDRGYVRKQGNQLVPTFTAMAVTKLLEKNFSRLVDLQFTARMEQDLDDIANGQAERLPYLKSFYSGETGLDEQVKQNEAGIDPREACTLDIDGVNAKVRLGKFGAFFEGERDGQPVTATIPDDIAPADLTNELAEKLITQKSQGPQSLGIDPESGLPIFLLIGPFGPYLQLGEMKDGEKPRRVSIPKTRDVSTVKLEDALEYMKLPKALGPHPETGKVVKAGIGMYGPYVHHDKTYKSLDKTDDILQMTMERALELLAQARVRVPVAPLKELGAHPVDGDPVQIFEGKYGPYIKHGKTNATIPKERELDSVTLEEAVRLLDERVAKGGGSTGRRGGKKVTKKAAAKKAAASAAMATPKKATAKKKAAKKATKKSVS
(638) DNA topoisomerase 1 [Parabacteroides distasonis ATCC 8503]
1
MQKNLVIVESPAKAKTIEKFLGKDYKVMSSYGHIRDLKTKDFSIDLEHNYAPEYVIPSDKKKLVTELKNEAKKAEQVWLASDEDREGEAISWHLYEVLGLKPENTKRIVFHEITKNAILHAIETPRDINIDLVNAQQARRILDRIVGFELSPILWRKVKPALSAGRVQSVAVRLIVEREREINEFVSEAAYRVIASFILPDGTTILKAELNRRLKDKEEVEAFLESCKDASFTIDDISKKPVRKTPAPPFTTSTLQQEAARKLGYSVSQTMMIAQRLYESGLITYMRTDSVNLSDLALGTAKEAILDTYGEKYYKFRQYHTKSKGAQEAHEAIRPTYISNDEISGTAQEKRLYELIRKRTIACQMADAELERTTISVGIGGKKEKFVATGEVITFDGFLQVYRESFDDENEKEQENGLLPPVTLNEVLSMKDIVATERFTQRPPRYTEASLVRRLEELGIGRPSTYAPTIQTIQNREYVVKGDKEGTERTYNIITLDRHTIKEVQKTEIVGADRNKLMPTDIGTVVNDFLMEYFPGVMDYNFTASVEKEFDAVAEGEMVWTDAIDKFYKLFHPIVEEAASVRTEHKVGERELGIDPKSGKPVFVKIGRYGPVVQIGQAHPEDKEAPKPQFATLMKGQSIETITLEEALKLFDLPRTIGEYEGKVMVAAVGRFGPFIRHDGKFVSIPKGLNPLSITAEEAIELIEAKKQKDEQRFIKKFDEDPEMEILNGRFGPYISYKKKNYRIPKTIEKPENLTLEECQKIIAEAGEKPAATKKRTTRKKA
(640) DNA topoisomerase 1 [Campylobacter fetus subsp. fetus 82-40]
1
MSKLIIVESPAKAKTIKNFLGSEYKVIASKGHIRDLPKSSFGIKIEDDKFTPEYRVSSDHSAIVKEIKDLAKNADTIYLATDEDREGEAIAYHIAAAIGKKPEMLPRIVFHEITKSAIQNALENPRSLNMDSVNAQQARRLLDRIVGYKLSPLLNSKIQRGLSAGRVQSSALKILVDREREIRNFKPIEYFSIDTKFKKDLEAELVEFEGSKIEKLTITNKDRAKFIVDKIKDESFSVANVESKERKTSPQPPFMTSTLQQSASNRLGFSPKKTMMLAQNLYEGVQTNNGFMGAITYMRTDSLNLAKEAISAARDLIKEQFGDKYLPKSANFYTTKNKGAQEAHEAIRPTNLSFTPTEAAKFLEKDLLKLYTLIYNRFLACQMSASVSETQNIFINSKSSIFKISGRKLTFDGFYRVYGDLDKDRILPNLNVGDKMELESLSSQSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISLLTSRDYVKVDKKQLIPNEIAFNITSMLEEHFNDIVDSDFTSKMEEKLDDIAENKADWQEVLSKFYHPFMQKIDDGKKNIKSQKVTEPIGEKCPECGGELVKRKGRFGEFIACLNFPKCKYSRNLKNEAKIEKKEPQKIGVACPQCGGDIVERFSKKGKFFGCANYPKCNFISKYQPTDQKCPQCGEMMVYKELKKGNFYECSACKFKKEGNNNE
(643) DNA topoisomerase 1 [Borrelia recurrentis A1]
1
MQQKRLIIVESPTKATTIKKYLDSSFSVEACIGHIRDLPNSAKEIPEEYKKFEWANLSIDYQNDFKPLYIIPSNKKMIIEKLKKVIKDQDEIYLATDQDREGETIAFHLKEVLQIKNYKRMVFHEITKSAIIDSLNNTREINMNLVNAGETRRILDRLYGYTISPLLWKKIAYGLSAGRVQSVGLQLIIEKEKSRINFKKANYYSITLECKHNKNNIQLKPTLEKIDNKNVAESKDFENDTGTLHEPNKTILIDKILMNSITKELKQINNIEVISIETKEIKLTPPKPFITSSLQQEINRRLKIGTKQIMSYAQKLYESGYITYMRTDSYEIAKTAKEKIKNIIRQKYGEEYIEKNDRMYTKAKMAQDAHEAIRPSEMFTPPEQIQIESETAKEIYKIIWDRTIESCMKDAIKKMGKIKFKYKNFTFKANFTKLIFDGFLKNNKEFHEDNIIDFSLIKEGDKFTILNIKPEQHETKPPLRYTEASLVQKLEKEGIGRPSTYATIISTLFEREYVFKQNNTLIPTIKGAAVINLLKKYFPILIELQFTSNMEENLDKIAIGKLDKIQYLNAFYNGKEGLKNTVSKIEPMISPEEFRMVYEYNNDKQFNYKINIGKFGPYLIFNGNNYAINLTTPLENLYKKDEIQKIITEKEIQPNILGVDPATGLNIIYKNSKYGGIIQLGEDIYEPQGFTKTGKPKKPKIIKAKKVSTKNIEYENITLELALQLLSLPKVIGKYPKTNEKIIATTGIFGDYIKTENDSIICPLKKDMKAYKITLEESIKLLDTKLAKNGIIVKIISLSKNKIGNKIYIYKQNDKFYAKIKRKKVNLPTNIDLNQIDATYVFGLM
(644) DNA topoisomerase 1 [Ruminococcus torques L2-14]
1
MAHYLVIVESPAKVKTIKKFLGSNYTVAASQGHVRDLPKSQLGIDVENDYEPKYITIRGKGEILATLRKEAKKSDKVYLATDPDREGEAISWHLAAALKLDEKKMRRITFNEITKNAVKASLKAPRDIDMDLVDAQQARRELDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIVADREAEIDAFIPEEYWSLDAQLKVKGEKRPLTAKFYGTEKKKMTIHSKEEMDEILKKLENEEFQITDIKNSERTRKAPLPFTTSTLQQEAAKALNFGTQKTMRIAQQLYEGVDIKGNGTVGVITYLRTDSTRISEEADAAARSYIAETYGEAYVAEGTKTKSADKKIQDAHEAIRPTDITRTPAAIKDSLSRDQFRLYQLIWKRFTASRMQPAKYETTAVKIGAGEYCFTVSTARVAFDGFRSVYVEAEEEKEESNVLVGHLSMDSVLTKEEFDPKQHFTQPPAHYTEASLVKTMEELGIGRPSTYAPTISLILGRRYITKEGKNLYLTEIGEVVNNIMKQSFPSIVDVHFTANMEGLLDMVEEGKVPWKEVIRNFYPDLEEAVEIAEKELEEVKIEDEVTDVICEECGRNMVIKYGPHGKFLACPGFPECRNTKPYLEKIGVPCPVCGKEVVIRKTKKGRKYYGCEDNPECEFMSWQKPSSKKCPECGGYMVEKGNKLVCADEKCGYVETIKKED
(657) DNA topoisomerase 1 [Bacillus atrophaeus 1942]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINEFKPEEYWTIDGSFLKGQETFEASFFGKGGKKLPLKSEADVKEILSQLKGNKYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAVEEAAAFIDQTYGKEFLGGKRKPAKKNENAQDAHEAIRPTSILRKPNELKTVLGRDQLRLYKLIWERFVASQMASAVLDTMSVDLENNGLTFRATGSKVKFSGFMKVYVEGKDDQLEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVGLDNKRFVPTELGQIVLELIMEFFPEIINVEFTARMEQDLDNVEDGNTEWVQIIDRFYTDFEKRVKKAEAEMKEVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPKCEEGNIVERKSKKKRVFYGCDRYPQCDFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVECDYKEEPQK
(659) DNA topoisomerase 1 [Roseobacter denitrificans OCh 114]
1
MPVVVVESPAKAKTINAYLGDDYTVLASYGHVRDLPPKDGSVNPDADFEMLWEVGYDSRKHVKAIADALKEDNALILATDPDREGEAISWHLQEALTKRKSIKKDTPVSRVVFNAITKAAVTEAMQNPRQVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVTLRLIVEREMEIEAFRAREYWSVKALLATPRGQEFEAKLTVLAGKKLDRFDIENQTQAELAVQAITSRDLSVKSVEAKPANRNPSAPFMTSTLQQEASRKFGMGARQTMSTAQRLYEAGYITYMRTDGIDMAPEAVTAARDAIKTLYGSKYVPEKPRIYKNKAKNAQEAHECVRPTDMMTKAEDLKTTDADQRKLYDLIWKRTLACQMEAARMERTTAEIASEDGQVGLRATGQVMLFDGFLRVYEEGRDDVAVVDDDDKRLPQIDQGDRLDKRTVTPEQHFTQPPPRYTEATLVKRMEELGIGRPSTYASVVTTIQDREYVRKDKNRLIPEDKGRLVTAFLSNYFRKYIGYDFTADLEDQLDTVSAGNADYKEVLGRFWRDFSAAIAETADLRITEVLEKINEVLEPHLFPPNEDGSDPRLCPNCGAGRLSMRTARSGGAFIGCSNYPECRYTRAFGPPGEEDDSGIPPEGKLLGEDGDDKIYAFKGRFGPYVQRGEVTEDNKKPPRQSIPKDWPPEDVDLPQALKLLSLPREIGPHPEDGIMVWANIGRYGPYLKHAPSTSDRGGTNANLESIEEVFTVGMNRAVQLLAEKVASRGRRGGAAKTLRDLGEHPEEGGPVAIMEGKYGPYVKWDKINATLPKDSDPAELTMEAAIALIDEKAASKGKKRRKAAPKKAAAKKTATKKAAPKKTAAKKKAPAKKAKE
(662) DNA topoisomerase 1 [Mesorhizobium opportunistum WSM2075]
1
MDVVVVESPAKAKTINKYLGKNYKVLASFGHVRDLPAKDGSVRPDEDFAMSWAVDTASGKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLKQKRALKDKPVSRVVFNAITKSSVLEAMANPRQIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFIREEYWQIAAILGTPRNEAFEARLTAFERKKLQKLDISNKAQADDVKAMLEGAAFKALSVEAKPTKRNPGPPFTTSTLQQAASSGLGFSATRTMQVAQRLYEGMEIGGETTGLITYMRTDGVQMAPEAIDAARDAIAKEFGPKYLPEKPRVYTTKAKNAQEAHEAIRPTDFMRTPASVRQYLDSDQMRLYELIWKRAISSQMQPAEIERTTVEIEAVNGSRTAELRAVGSVVRFDGFIAAYTDQKEDDAEDEENRRLPEIRVGEQLARQAINATQHTTEPPPRYSEATLIKKLEELGIGRPSTYTAILKTLEDRDYVTIDKRRLVPQAKGRLLSAFLESFFERYVEYDFTASLEEKLDEISDGKLAWKDVLRDFWKDFSGAVADIKELRVTDVLDALNEELAPLVFPAREDGSNPRICPKCGTGNLSLKLGKFGAFVGCSNYPECSFTRQLGDAANPNGENGGGEDGTKVLGKDPYTAEEITLRSGRFGPYIQRGDGKEAKRSSLPKGWTPESIDHEKALALLSLPRDVGKHPESGKMISAGLGRYGPFVLHDGTYANVDSIEDVFSIGLNRAVTVIAEKQSKAKGGRNGGTAAALKELGDHPDGGGKIVVRDGKYGPYVNFGKVNATLPKGKDPQSVTIEDALALIAEREAKGGGGKKPFRKAASPATKKAATKKPAAKKKG
(664) DNA topoisomerase 1 [Dictyoglomus turgidum DSM 6724]
1
MDNEKLIIVESPAKAKTIEKILGKEFKVLASYGHIRDLPEKELGVDIENNFKPKYVLLPSRKKIIDTIKDLSKKAEKLYLATDPDREGEAIAWHLVEELKLPKEKFTRIEFHEITPRAILEAIKNPREIDLDRVEAQQARRILDRLVGYELSPLLWEKVRKGLSAGRVQSVALRFICEREEEIEKFIPEEYWYIYGEFRDEEKVLYGKLILYKDEEVNVKNEQEVNKIIRILNCLDYRIDKVVIKEEKRTPPPPFITSTLQQEASKRFGFPVGKTMKIAQSLYEGVDIGNERIGLITYMRTDSTRIAPEAREEAVQYIESGFGKEYVGKEHKEKKKLGVQDAHEAIRPTSVFRDPEKIRKYLTDEQFKIYKLIWERFIASQMNHAIFEVVEIYIKGGDYVFLSKGKKLKFAGFMSLYMEKEENGEEKDEVNIDYVPEEGKNVKLTTLIPRQFFTEPPPRYTEATLVRTLEKYGVGRPSTYATIIETLKERKYVEVKDRTLVPTTLGKVVNDFLTKQFPHLIDVKFTARMEEDLDKIESGKVKAIEVLKKFYPAFKEELEKVSKNIGKIQVIEKTDEICPLCGSKLVIRENKNGKYYACSRYPECKYTKPIYEEAQGRCPLCGGVVVKKKAKKTKKTFWGCINYPECSFASPYEPLNEKCPQCGSTMLKGNGFKKCSNKDCNYIVWTGRRKRWKKSK
(665) DNA topoisomerase 1 [Thermoanaerobacter wiegelii Rt8.B1]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYSNPEANYASKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFLASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQERTKLFLEELKPMQHFTQPPPRYTEASLIKELEERGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVQEFYKDFYKTLKIAEEQMEEIDVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRNYYACENAPDCDFILWDKPVNEKCPVCGSLLVEKNTKNGHILKCSNPGCDYQKEVK
(666) DNA topoisomerase 1 [Chlamydia pneumoniae]
1
MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDKQEVINHIRKLAAKCEKVYLSPDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEALKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEKARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGVDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAHEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQITPAIYDTLAVQITTDTEIDLRASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHKGKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAEDTPWDSPCPLCGGVMKVRHGRYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSEYPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKSSEKKTGPLFLPSPDLAKMIGNEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATIIGPNPIDMFQLSKHLSQHLTKVSNDESSASS
(667) DNA topoisomerase 1 [Chlamydia pneumoniae]
1
MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDKQEVINHIRKLAAKCEKVYLSPDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEALKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEKARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGVDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAHEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQITPAIYDTLAVQITTDTEIDLRASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHKGKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAEDTPWDSPCPLCGGVMKVRHGRYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSEYPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKSSEKKTGPLFLPSPDLAKMIGNEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATIIGPNPIDMFQLSKHLSQHLTKVSNDESSASS
(668) DNA topoisomerase 1 [Chlamydia pneumoniae]
1
MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDKQEVINHIRKLAAKCEKVYLSPDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEALKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEKARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGVDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAHEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQITPAIYDTLAVQITTDTEIDLRASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHKGKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAEDTPWDSPCPLCGGVMKVRHGRYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSEYPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKSSEKKTGPLFLPSPDLAKMIGNEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATIIGPNPIDMFQLSKHLSQHLTKVSNDESSASS
(669) DNA topoisomerase 1 [Chlamydia pneumoniae]
1
MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDKQEVINHIRKLAAKCEKVYLSPDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEALKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEKARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGVDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAHEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQITPAIYDTLAVQITTDTEIDLRASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHKGKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAEDTPWDSPCPLCGGVMKVRHGRYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSEYPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKSSEKKTGPLFLPSPDLAKMIGNEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATIIGPNPIDMFQLSKHLSQHLTKVSNDESSASS
(672) DNA topoisomerase 1 [Gemmatimonas aurantiaca T-27]
1
MAKSPARKTPVSKTAVRKTAAGKTTARKAAARAEAIDLPEDDEPAPAGGTSLVIVESPAKAKTIGKYLGRGYTVKATVGHVRDLPAKKLGIDIDHGFAPEYVTIEGKEDILTDLKKVAKGAREIFIATDPDREGEAIGWHVEQYFTQPKRHAVSAPIRRVMFHEITKDAVHKSMAKPMDIDNKKVEAQQARRVLDRLVGYKASPVLWKTVKKGLSAGRVQTVALRLIVEREREIRAFTPVEYWSIAADLQKGQQPFTAKLHQLDGKKPEIGNGTEAERIIADLAGRKEFVVTEVKRRERRKNPAAPFTTSTLQQEAAKKLGFGSKRTMRLAQDLYEGIDVGIDGATGLITYMRTDSTRVSEDAANSARESLRAQFGDDFLAPAPQLYPSGKANAQDAHEGVRPTDPSRRPEQVQKFLTADQFKLYQLIWQRFMASQMAPAVFDTTTVDFNIPIKVADAERNYLFRATGSVVKFQGFLALYREAREEGDAKALEDEQALPVLEVDERVPVKAITPTQHFTEPPPRFSEASLVKELERAGIGRPSTYASIISVLVERRYVSLEQRRFFPTSLGETVEKVMVKKFPDVFNVGFTAQMEEELDKIAEGEIDWVRALGDFWTPFQRTLNDNDLDALIGEAYDLSALETERCPDCGGKLVAKGGFFGPFVACENHPKACKYTRPIKGEKKPAELTNYMCQECGAPMVIRHGRSGDFLGCSKFPKCRGTRSMPTGVKCPKDGGEIAERRSKKRGKAFYGCENYPNCDFVVWDKPVAETCPECGYVGAEAKSNKTRGSFRKCLKCSNEWDVAAPDEAAEVAEVA
(674) DNA topoisomerase 1 [Chloroflexus aurantiacus J-10-fl]
1
MGEKVVIVESPAKARTIQKYLGKGYKVASSMGHVRDLPKSGLAIDIEHDFAPSYEIVKPKVVSELSQALRNAEAVYLATDPDREGEAIAWHITQAVKLPKKTPVYRVVFQEITRNAVQQALQQPRQINQNLVEAQQARRVLDRLVGYQLSPLLWDKVKRGLSAGRVQSVAVRLIVEREREIEQFQPQEYWTIEADLLKDAGVAPRDLFRAVLIERDGKKLEKFSIENREQAEAIVADLQGAAYTVVRVTRRDKRRSPAPPFTTSTLQQEAARKLGFSAKKTMTLAQRLYEGVDIGGEDGMVGLITYMRTDSVQVAAEAQTEARDVIGKRFGKEYLPDQPPVYKTKAKGAQEAHEAIRPTSSARLPEQLSGKLENDLWRLYDLIWKRFIASQMAPAVFDSTTVDIAATPVVAGAPAYLFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPPLAEGEALQLVELLPIQHFTEPPPRYTEASLVKELERLGIGRPSTYASILSTIQEREYVEMVDKKLIPTTLGRVVTDLLVEHFGNIVDYDFTSALEQQLDDIAEGSKKWVPVLREFYGPFRSTLEQAQRQMRNVKREEIVTDLDCPKCGQGKLVIRFGRNGEFLACSRYNREGDGESCDFTSDFHRDEQGQIVIDKASAPETSDVLCNVCGRPMVIKKSRFGPFLGCSGYPECNNTRRIGRDGKPVPLPEPTGVQCPKCGEGELLRRRGKFGRPFYGCSRYPKCDYITNTLDEAQAGEAPAEPAKNEPALPSPSRSSKRTRKSA
(677) DNA topoisomerase [Thermodesulfobacterium geofontis OPF15]
1
MILFVVESPTKIRTLQKFLRDGFIFRATLGHIKDLPKAKLGIDLKTFEPALYWLPNKKKVLSEIKKISSKVKEIYLATDPDREGEAIAYHLYEYLSKANPKLNFKRLDLIEITEKGLKLALSNLREINPYLYQSWLTRRVLDRLIGYLISPKLSKTFEKSLSAGRVQSVALRLIVEREKEIENFVPEKSYSLEIKLKRDSVTILSEFYYKNRLYKTKNKEELIKFYKEKLLNNLIILEKIEEKIEKKNPPLPLKTTTLIEISQKMLGYEPKQTMYYAQRLYENGYITYMRTDSVRVSEYAQKMVKEFIKLYFGEEFVGKERKIRQNRFVQDAHECIRPTDVFREEVPLSEPEKKLYQLIRTYFIASQMSPAKYLIRTYIFTNQNLEKDYFLKAIFKKLLFEGFLKVFKGEKEEKEFIDLKAGEIFEILAWKIKEHITEPPSPYTPSTLIKKLESLGIGRPSTYATLLDILYKRKYVTKEKGFLRPTELGKEVCEYLIKSFPEFLDYKFTSKTEEDLEKVVENKKTYQEIVSFNYEILKNYL
(680) DNA topoisomerase 1 [Phenylobacterium zucineum HLK1]
1
MNVVIVESPAKAKTINKYLGSDYKVLASYGHVRDLPAKDGSVRPDEDFAMSWDVDAKAAKRLSEIAEAAKGADRVILATDPDREGEAISWHVLEVLQKKRALKDAKVQRVVFNAITKSAVTEAMANPRELDMELVEAYLARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDRELEIERFRTQEYWTVEAEVAAGGDPFTARLVKHEGKRLSKFDLGNEASAFAARDAVKAATFKVAAVERKPGRRSPPPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVQTAPEALDEARAVIGGLYGKDYVPEKPRFYSTKAKNAQEAHEAIRPTSLGRNPGKLRLEGDLGRLYELIWKRMIASQMESARIERTTIDLESADGRTGLRATGQVVTFPGYLAVYEEGRDDPEDEEGGRLPQVAEGAQATVRQAKADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASILERLRDRSYVRMEKQRFVPEDQGRIVTIFLEEFFGKYVEYDFTADLEDQLDQVSAGDLDWKVLLKNFWADFNAKVGELGQIGTREVIDALDESLASTLFPPMADGSDPRVCPRCGSGRLSLKPSRTGAFIGCSNYPECRFTRPFGPPDAEGAEASGDRDLGTDPQTGETVWLKAGRFGPYVQLGEGEKPKRSSLPKGWSVADMDLEKALRLLRLPREIGPHPEDGKPILAGIGRYGPFVQHNGTYANLPSVDEVFEVGLNRAVDLIATKRAGGKRGGEAEALKDLGAHPADGQPVRVLAGRYGPYVKHGSTNATIPKGADPKALTLDEAVKLLAEREAKGGGKKKPARKAKAEPKAKKAPAKKAPAKKAAAKTPAKATPAGDIDDDESPF
(682) DNA topoisomerase 1 [Prosthecochloris aestuarii DSM 271]
1
MASSSAAPSAKNKTLIVVESPSKAKTINKYLGTGYKVFASVGHIKDLPKKEIGLDFDNNYEPRYEVIAGKEKVVRQLRKLAGEANDIMIATDPDREGEAIAWHIANEVEGARKPVQRVLFNEITKNAIIDAISHPRQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVFRGLSAGRVQSVALRLICEREDEIGKFETREYWTLFADFTTVSGETFSAKLVKINGKDVDITNENDATAVADTILSRIYGVTDISSRIQQRKPPVAFTTSLLQQAASNQLGFGSKKTMRAAQQLYEGIELGPEGATGLITYMRTDSTRVSAEAVGQAQSYIEQQFGPQYAGQGRAGKNDKKTQDAHEAIRPTSIFRTPAAMKPFLTADQFKLYELIWKRFLASRMAPAKIELTKVEVSDHEGEFLFRANGSKVLFPGFLQVYSDQKELDYEAKTSTKDDEEKEQTVQLPKKLDLNEKLDLQTLDKKQSFTRPPARYTEASLVKELDNHGIGRPSTYAAIFSTLQDRRYVELLKRKIIPTELGRDVSLILVANFPDLFNVTFTAQMEDELDKVAAGQDDYEKVLDSFYKPLEASLSDRKKDPVLPQNDKAERCDKCGTGKMVVKWTSSGKFLGCSEYPKCKNIKPLSNSKPKPKGTGIACPGCEDGHMVLRDGRFGPFLACSNYPKCNTLLNLDKQRRIQPPKTPPLETDLSCPKCGAPLYLRTGKRGLWLGCSKFPKCRGRQAWGQLEPALQQHWQSVMDQHLAAHPQVTLLMTDGSPVNMQLTVDEIMVFAEEKGLIPLMEEQKTGVSS
(684) DNA topoisomerase 1 [Roseiflexus castenholzii DSM 13941]
1
MGEKLVIVESPAKARTIQKYLGSGYRVEASMGHVRDLPKSNLGVDLEANFAPVYEISPGKEKIIAALRKSIRQADAVYLATDPDREGEAIAWHITEAAKIPRDKPVYRVVFTEITPGAVRSAMASPRDIDRRLVDAQQARRVLDRLVGYKLSPLLWEKVRRGLSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQNASDSQRDAFRAMLIERSGKKLEKFDIGASDQAQAIIADLEGAAYIVRKVTRRDKRRSPAPPFTTSTLQQEAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARRVIRERFGEAYLPAKPPVYKTKAKGAQEAHEAIRPTLSRRTPEQVQPYLTSDQYRLYDLIWKRFVASQMEAAVFDSTVVDIGAGRDIGGRGAGSDPYTFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPLLEEGEALNLLQLLPVQHFTEPPPRFTEASLVKELERLGIGRPSTYAPTISTIIEREYVELADKKLVPTTLGRVVTDLLVEHFPSIVDYGFTSEMEQQLDDIAEGEKEWAPVLRAFYRPFEQKLAEAQRSMRNVKREEILTDLTCPRCNQGQLAVKFGRNGEFLACNRYPECDFTSDFHRDSDGRIVLDAPASPETSDVLCDVCGRPMILKKSRFGPFLGCSGYPECKNTRRLDKQGKPAPLPKATGVTCPKCGQGELLERRGKFGRPFFGCNRYPKCDYLVNSLDEVAHYTPDANEASKPQAEEPTATDAKATPARKRVKTDANGAAAAGKRVKTDANGAVAGEPMKTKASANGKRAKTGTNGAAAAPPKKRGTER
(687) DNA topoisomerase 1 [Acidithiobacillus ferrivorans SS3]
1
MAYQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDLQPKEGAVDTEHDFAMRYAAIERNERHVDAITKALRGAEKLWLATDPDREGEAISWHLVELLRERHLLGNMPTQRVVFHEITKKAVQEAIANPREIAMDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASHLQQAGSDFSARLTHWQDKKLEQFDVTESDQAAAIRSGMEDDLSRQPLRVREVERKSRQRQPAAPFTTSTLQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRDFIGGHYGGEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPEALQGVLERDLWRLYDLIWKRSIACQMAPARMDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDEGNRILPPLNTGDEPQVLDINPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQRRFRPTDLGRVVGRFLTNHFERYVDYGFTASMEDELDAISRGEKQWQPVLSAFWGPFRALLDEKANVSRTEATSEALDEACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAEPVGRDCPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQPKSSGVTCPECGEGELVEKRSRYGKIFYSCNTYPKCNYALWGPPVARACPRCAWPIMIEKSGKRLGEQLACPQSECAFHFPANASDTEIAAMLSDYTPPPPREKRAPPAKKAAPARKAAAKSTRKPAVKAATAANKPAKAETTAAVVKKPSKAKTPAAKKSTSSKNTTSSASEAATPAARKRSVKNVTNS
(689) DNA topoisomerase 1 [Oscillibacter valericigenes Sjm18-20]
1
MAKQSLVIVESPAKAKTIEKYLGKEFRVKASMGHLRDLPKSTLGVDVEHDFDPVYQPIKGKEDIISDLKKSAKAADTVYLATDPDREGEAISWHLKQLLNLPDSKTHRVTFNEITKKVVQESIQEPRDIDQNLVDAQQARRILDRIVGYQLSPLLWKKIRRGLSAGRVQSVATRMVDDREREIEAFKPEEYWTLDAVFRGDDAKKTEFTAHYHGRDGKKVELKSAEEVEAVVEETRNQAFAVSAVKRTDKQRSPSPPFTTSTLQQDASRKLSMTPRRTMAIAQQLYEGVDIAGEGTVGLITYMRTDSLRISEEALSAAKSFILGRYGKDYYPARTRHYKAKANAQDAHEAIRPSNVALTPEQVKGDLTGEQYRLYKLIWSRFLASQMENAVYDSVSVDIAAGEHMFRATASGLKFAGYTAVYEEGKDEEKEEKESPLPALREGEPLALKEFYRDQHFTQPPAHYTDATLIRAMEEQGIGRPSTYAPTVSTIIDREYVIKEGKYLKITNLGRVVTELMKQRFSDIADLQFTAHMEQKLDSVEEGVTPWKNVLRDFYGDFEKNLKDAETALEGTRIKVPDEVSEEICPECGRNLVVKSGRFGRFLACPGYPDCSFTMPLVVVMPGRCPKCGGRLMKRTGVSKKTGKQYNYYCCEHRTARDEAAKCDFMTWDVPVKDDCPVCGQTMFKRSGRGYKRPYCVNPNCSNFLPEDQRGYPKKKTDEGGESAGSAEAAEESATDVTAAKKATAKKPAAKAKSKRTAKEPAAKKSAAGSGADKKTGVTKTAARKPAAKKTAAKKTVAKKSAAEKEN
(690) DNA topoisomerase 1 [Candidatus Phytoplasma australiense]
1
MKKKVIIVESPAKIKTLSRFFDDKVEILSSKGHIRDLSLSGKDRLGIDIKNGFIPKYEIIKEKKTLVESLIKKTKNKEIFLATDPDREGEAIAWHLSKVLNLNPQMANRIVFREITKEVVLKALQNPRTVDELLVFSQETRRMLDRIIGFKLSRLVRRIKSQSAGRVQSVALKLIVDLEKEINSFVPEEYNLITAFFPFFQAEYQNPNNKKIKSAEALGIVAKITNKPFIVKKIKQTETFSKPKKPLITSTLQQEAINNLYMTSNQTMRVAQKLYEGIDIEGESIGLITYMRTDSPRFSEVFVKDAQKLIKEKYGQKYLAVFKQNQKNKAQDAHEAIKPTDLSKTPESLMSYLDKYEYKLYDLIYKRSLASLMKPAIFQKNQVFFEVEKHSFLTEGLIKTFDGYQKILKDNLQDKIIPTFNLNESYFPEKIETFQKFTTPQARFSEATLIKTLEKLNIGRPSTYSQIIFTLKKRFYVDMIEKRFQPTEQGILTIQNLELFFKQFLDYQYTAQMESDLDKIASGLVDNKQLMQTFYTNFLQLYQIADQKLEKIKPIETDQKCNLCNEGNLLIKKSHYGSFLGCSRFPDCKNTSPWKVQEKNKSKDSDHSNQTDQKCNLCNEGNLLIKKSRYGSFLGCSRFPDCKNIVKIKNKPNSK
(699) DNA topoisomerase 1 [Rickettsia slovaca 13-B]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKIKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPSENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(700) DNA topoisomerase 1 [Granulibacter bethesdensis CGDNIH1]
1
MPHDVAIIGILMTDVVVVESPAKAKTINKYLGGNYTVLASFGHVRDLPPKDGSVRPDQDFAMDWEADERGRKQVAAIAKALKGAETLYLATDPDREGEAISWHVRAMLEEARALKGVEVRRITFNEITRNAIRHAIEHPRDLDQPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFRPREYWTVETHFFTPAGAPFTARLTHLDGKKLDQFDLNTEALAMRARALVEQGQFHVGMIERKKVKRNPPPPFTTSTLQQESSRKLGFGAQATMRLAQQLYEGVEIGGETVGLITYMRTDGVQMAREAMFSIRDHVKDSYGLDYLPAAPREYSSKAKNAQEAHEAIRPTDVERTPDSVARYLNPEQRRLYELVWKRAVASQMQSAELDQVTVDIFPQTGDAKSVQLRATGSIIAFDGFLKLYREGQDDTEEEEGRMLPPMAERDPLRQDRVDASQHFTQPPPRYSEASLVKRMEELGIGRPSTYASILSVLQDRNYVRLDKRRFHPEDRGRLVTAFLTSFFERYVDTNFTASLETQLDEISDGRADWRQVMQAFWQDFYQAVEQTKDLKISDVIDALDRDLGPHFFPTREDGTDPRICPACGDGRLGLRLGRHGSFIGCSNYPGCSYTRRLGIDGAEGEAETLKEGMRVLGQHPETGEDITVKRGPYGLYVQQGEAEEGSKKKPRRASLPRGVDGETILLDQALGLLSLPRLVGIHPETGEPIEANLGRFGPYVKMGGIYGNLDKDDDVLTVGLNRAVDVLAKKMASIRTLGTHPKDKEPVVVRKGRFGPYVQHGQVVANVPREIEMDDVTLDDALGWLAEKGKPLKAKGGRKVAAKSSGKKAASADGNEAQPLKKATAKKTTRAAGAGKAAAKKSGTRSATAKTAKAER
(701) DNA topoisomerase 1 [Nitrobacter winogradskyi Nb-255]
1
MNIVIVESPAKAKTINKYLGTSYEVLASFGHVRDLPAKNGSVDPDANFQMIWEVDPKAAGRLNDIAKSLKGADKLILATDPDREGEAISWHVLEVLKQKRALKDQKIERVVFNAITKQAVTEAMKSPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVPREYWSLVTTLATPRGETFDARLVGADGKKIQRLDIGNGAEAEDFRKAIEAANFTVSTVEAKPARRNPQAPFTTSTLQQEASRKLGFAPAHTMRIAQRLYEGIDVGGETTGLITYMRTDGVQIDGSAITQARKVIGEDYGHAYVPEAPRQYQTKAKNAQEAHEAIRPTDLSRRPSDMKRRLDADQARLYELIWIRTIASQMESAELERTTVDIAARAGARTLELRASGQVVKFDGFLALYQEGRDDEEDEDSRRLPAMSEGEALRRENLSVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLYGEDKGRVVIAFLENFFARYVEYDFTANLEEQLDRISNNEVSWQQVLKDFWDDFIGVVNEIKDVRVSEVLDVLDNMLGPHIYAPREDGGDPRQCPTCGTGRLNLKAGKFGAFVGCSNYPECRHTRPLAADGEAGGDRVLGKDPESGLDVAVKSGRFGPYIQLGEASDYGEGEKPKRAGIPKNTSPADIELDLAVKLLSLPREIGKHPETGEPITAGIGRFGPFVRHEKTYASLEAGDEVFDIGLNRAVTLIAEKVAKGPSRRFGADPGKPLGDHPTLGPVAVKSGRYGAYVTAGGVNATIPSDKTQDTITLPEAIALIDERAAKGGGKPKRAAKKAKPAQTEKAGKDGAATKKPAKKAASKQASTKPKSEAVSKARGSIAAAKAPPNTVKAPTKKSAGKNG
(705) DNA topoisomerase 1 [Nautilia profundicola AmH]
1
MAKNLIIVESPAKARTIKNFLGKEYEVVASKGHIRDLPKTSFGIKIEEDKFIPQYRVTADHQPIAKELKEKAKKAETIYIATDEDREGEAIGYHIAHVIGKKPEELPRIVFHEITKTAIKKALENPRTIDLNRVNAQQARRLLDRIVGYKLSPLLNKKIQKGLSAGRVQSAALKLVVDREREIKAFKPQEYWSIEGIFKKIEGSLIKYNGKKLDKFDIKSKDEAQKIVEELKPLEYTVREIETKTTTVKSPAPFMTSTLQQVASSELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQQAALEFIKQNIGEEYAQAKTYATKNQNAQEAHEAIRPVDVRLTPDDLKNYLKPDELKLYALIFNRFLASQMKDAKFETQNIYIANDKGEFKISGRKLIFDGFYKVYGKPSANTLLPEFEKGEKLKPEDVKATQHFTKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEVKDKKLHPTEIAFSVIETLEKHFPDIVDANFTANMEEMLDEVAEAKKDWQEVLKDFYNPFMELVNKGYKEIPSQKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYPKCKYTRPLEESKEEKKTDVKCDKCGADMVVKKGKSGEFLACSNYPKCKNTKPLNAPEVLDDVKCPECGGDIVKRKSRRGEFYGCANYPKCNFISKYRPVNKKCPECGYLMAERTYRKKDVYECIKCKHREEAKK
(712) DNA topoisomerase 1 [Roseburia hominis A2-183]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVVASNGHVRDLPKSQMGIDVEHDYEPKYITIRGKGDILAKLRKEVKKADKVYLATDPDREGEAISWHLSQALKLDGKNVRRISFNEITQNAVKASLKQPRDIDMNLVNAQQTRRILDRIVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWTLDAKLKADGEKKPLTAKFHGDENGKLAITCREEADRIMDEIRGERFEVLEVKKGERVKKAPLPFTTSTLQQEASKTLNFPISKTMRIAQQLYEGVDVKGQGTVGLITYLRTDSVRISDEADADARAYIAQNYGEEFVATQTVTQKGGAKIQDAHEAIRPSDIARTPAVVKESLSRDQFRLYQLIWKRFAASRMASAVYETTNVKIGAGKYRFGVAASKVSFEGFMSVYTSEDDEKDTNNVLLKGIDEDTKLTLDTFDEKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTITTLLGRRYIVKEAKNLYVTELGEVVNQIMKESFPSIVDEHFTANMESLLDSIGEGAVNWKTVVRNFYPDLEAAVEVAEKELQKVKIEDEVTDVVCDQCGRNMVVKYGPHGKFLACPGFPECRNTKPYLEKIGVPCPKCGKDVVLRKTKKGRKYFGCENNPECDFMSWSRPVAEKCPKCGGYMVVKGNKIACADAGCGYTRDRKADEDTK
(719) DNA topoisomerase 1 [Neorickettsia risticii str. Illinois]
1
MNVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKGSVDVTDSFEMLYKLTDTGETVVPQLIKDVKNATALYLATDPDREGEAISWHLVEVFKENDVLPKNVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSISPVLWKKLPGSKSAGRVQSVALRILCDRENEIGLFTPEEYWIVSVNMTDGEGLVIPTQLSHINGEKLERMSIRGAEEAEKIVEEIRELPFLVEEIKKKELKQKPSPPFITSTMQQTASTVLGFSVKKTMSLAQKLYEGIEIGGAIEGLITYMRTDATHLSVESVDAIREFIQKKFGQEYLPESPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAITSSQNIVFISQDEKFKTSASASLLIFDGFNAAFSHGKNKNKNQGVIDFIKKHKEGAQVKVGDVLPTQNFTEPPHRYSEAGLVKHLEELGIGRPSTYATVVSVLQERGYASIVNKSFIPENRGRLVSEFLVHFFSKYVEYHFTAEMEDRLDKVADGTIFWLDVIQDFWDSFHSNVEEVEKVPITEVLAFVNGALAKQKLVSAEVKVGDKCPKCEKGYMHLSVSRYGVFLGCTNYPVCRFIVNSYSTDDDTEYPKQIAQDISLHKGPYGIYLKYKGKNSSIPKDVDPVSIDEEFAHKIASLPKILGKHPADGKEIKMGLGPYGLYLFWNAKYYNLQFSQMDEMTLDKAVQFIQSYVIHDKSLLRVLGSYEGEEIQIRDGRYGPYIKCSKMNVPIPKAESPESLSIETAILLIEKKKNTSKSAKKVATKRKVSTKEKK
(724) DNA topoisomerase 1 [Lacinutrix sp. 5H-3-7-4]
1
MAKNLVIVESPAKAKTIEKFLGKDFKVESSYGHISDLPSKELGVDVEGDFDPKYQVSTDKKAVVKKLKDLAKKAEIVWLASDEDREGEAIAWHLAESLGLDKEKTKRIVFHEITKAAIQKAVENPRQIDYDLVDAQQARRVLDRIVGYELSPVLWRKVKGGLSAGRVQSVSVRLIVEREREIQAFNAEASYRIDAEFSNEEGQSFKAKLPKTIKTKAEALKFLEKNAKTTFKVSDLEKKPAKKAPAAPFTTSTLQQEASRKLYFSVSKTMTMAQRLYEAGLITYMRTDSVNLSKEAKQGAAKEIIEAYGKEYAKERNYKGKSKGAQEAHEAIRPTDFSAHSAGLDNDQVRLYELIWKRAIASQMSEAKLERTNVKIKAADHKEVFSANGEVITFDGFLKVYLEGTDDEDLEQQEGMLPAMKVGETLLNNSITATERYTRAPYRYTEASLVKKLEELGIGRPSTYAPTISTIQNRNYVEKGTVEGTERNYTQLVLKNGDVKDNLLTEKVGSDKGKLVPTDIGIIVTDFLVNHFESILDYSFTANVEDQFDDIADGKADWKKVMKSFYKDFHPRVIDVQENAERESGERILGEDPKTGKRVSVRLGKFGPMVQMGTVDDEEKPTFASLSPDQQLGSITFEEAMDLFKLPKKLGEYKDESVEVNNGRFGPYVKFGKAYVSLPKGTDPLSVEYDYAVELIKEKEKADAPIYTYKDLPVQKGKGRFGPYIKWNNMFINVNKKYDWDNLSEDDIIELIEVKIQKEIDKVVHNWEDEGIRVEKARWGRHNVIQGKVKIELPKTVDAAALTLEEVKGIIEKNAPKKKVTKRKTAAKKKTTTRKKTTAKKK
(728) DNA topoisomerase 1 [Leptospira borgpetersenii serovar Hardjo-bovis str. L550]
1
MSSLIIVESPSKAKTIGGYLGKEFRILATLGHVADLPKTTLGLDLKNRFEPEYVVLPGKKKILSEIIKAAKESQRIFLATDPDREGEFISAYIRDRLKKKSNVFRIRFTEITRNAILSSLQNPDTIHESLVEAQKTRRVGDRLIGYFISPVLWREIGPGLSAGRVQSVALKWICDREDEIRNFHSEIYYNVLLYVHDKKGIEGVFQRVGDRIFSEEKANLILQNVQKEKNLRISEKKESHKKNLPPPPFQTASLQQEAFRKLRFSSKKTMSIAQKLYEGMDLGNGKREGLITYMRTDSVRLSPDFVERANSWIISEFGETFANKLERKVKKSSKKIQDAHEAIRITDPFLTSESAKNFLGKEEASLYELIWKRTISYLLPPEEFLNTEYSIFVAGEYFQLETKKTLFPGYKILNEADKKANPNWEKGELLTLQKAECEKKQTEPSPRYSEGTLVAKLEREGIGRPSTYSTVSEILVKRKYVEQEKKFFYPLPLGEKVNFFLQSGFGDLFREKFTAELESNLDRIEKNEIDSLVILNRLWSDLQTQIQNSKFVASVFRKEWAEIREKKKETSWGICPLCRDGSLQKKKTSRKKEFYQCSRFPDCEYVNYELPKP
(729) DNA topoisomerase 1 [Treponema paraluiscuniculi Cuniculi A]
1
MEVRGLQPKRQKTFARKHLVIVESPAKAQTIEKYLGTQYVVRASMGHVIDLPKSRLAIDIEHDFQPEYITVRGRAQCLKELRTLSKQSLQVFLASDRDREGEAIAYHLAQSIQAYCDTPIKRIVFNEITPHAIRAAIGHPVPIDTAKVNAQKARRVLDRLVGYHLCPLLWHKVKNGLSAGRVQSVALRLICEREVEVERFVPEEYWTVEGTFEKDKKSFSALLILIQGKKAVFKSKQEATSAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQCAANRLGFTSRKTMQVAQQLYEGVSLGTHRVGLITYMRTDSVRVSEAAVKEVRAWIATHFSDALPGTPNRYAAKGKSQDAHEAIRPTYVAHTPERIKAHLTRDQIRLYTLIWERFVASQMTDARVRSLTFEITAGPAVFSATETQVIEQGFYRVLKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHFTQGPVRYTDASIVKMLEEKGIGRPSTYAPTISVLLDRYYVTRIQKQLMPTPLGKVISDLLTTYFHDVVDVSFTARMESKLDEVEEDKIKWNCVIADFYPAFSEKVSTVMKDLNSMRGVFDEKTDVVCSQCGDTMVKKLGRFGFFLACGKFPECRNTQPVPLAKCPRPACDGNIVGKKTRGRKEFYGCTRFPVCDFVTHFKPTSAVCPQCRCFLVEKSNRRVGTYTACVNPECRYVSPTRKNLSLGKEAVLDGSHRGAQDKGAVQHYE
(731) DNA topoisomerase 1 [Meiothermus ruber DSM 1279]
1
MPDSTLIVVESPAKAKSIQKMLGAGYEVRASKGHIADLPEHELGVDTQADFAPQYTVKKDKQPIVEELKRAARGKRVLIATDPDREGEAIGWHVARLLGLNPQTPLRVEFHEITPKVVRAAVQKPRPIDQSLVDAQQARRVLDRLVGYQLSPVLSMEFRRRALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLEGRFESEGQQFKAMLYSLGSERVQSGDKFLITSEKQAQEIARLAKDVSGYRIGSIERRERRRNAPPPFITSTLQQAASSRLGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDSTRVSQEALAEVRAFIPRHFGPAYLPEKPNFFAGKKAANAQDAHEAIRPTSTERTPDALRKHLSDEEYRLYQLIWQRFVASQMTPAVFDQTTVTVVGASGTPSGDLIFRAVGSVLKFDGYLRVYGREEGDEAENRLPPLQENASARLLEVTPEQHFTEPPPRYTDASLVKTLEEMGIGRPSTYAPTIDTLERRGYLERSGKSLKPTPLGREVTGYLIKSFPDVVAYDFTAQLESRLDEIEEGKAAWPKVVREFYEPFLKDFAKVPQKLCPKCGRPLELKVSRFGQFLGCTGYPECKHTERLELKKEPEPIGEACPACGEGQLVRRHGRYGSFISCSRYPECKYTRDEAPSTGIECPKCHAGEVVQKTSKRGKPYYRCNNPACDFLSFDPLLPDKCPLCGWNEVAKGRSGKRACTNPGCERYGGPKLEALNQRRTKSSSKTSGTAKNKVKDRAKASATWADLEPFITKAGLTPEQAEVARRTQGQQKQVAAVAKALNQPEEAVLKLFRQAMFKLRMEYGKARKEAVSA
(732) DNA topoisomerase 1 [Meiothermus ruber DSM 1279]
1
MPDSTLIVVESPAKAKSIQKMLGAGYEVRASKGHIADLPEHELGVDTQADFAPQYTVKKDKQPIVEELKRAARGKRVLIATDPDREGEAIGWHVARLLGLNPQTPLRVEFHEITPKVVRAAVQKPRPIDQSLVDAQQARRVLDRLVGYQLSPVLSMEFRRRALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLEGRFESEGQQFKAMLYSLGSERVQSGDKFLITSEKQAQEIARLAKDVSGYRIGSIERRERRRNAPPPFITSTLQQAASSRLGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDSTRVSQEALAEVRAFIPRHFGPAYLPEKPNFFAGKKAANAQDAHEAIRPTSTERTPDALRKHLSDEEYRLYQLIWQRFVASQMTPAVFDQTTVTVVGASGTPSGDLIFRAVGSVLKFDGYLRVYGREEGDEAENRLPPLQENASARLLEVTPEQHFTEPPPRYTDASLVKTLEEMGIGRPSTYAPTIDTLERRGYLERSGKSLKPTPLGREVTGYLIKSFPDVVAYDFTAQLESRLDEIEEGKAAWPKVVREFYEPFLKDFAKVPQKLCPKCGRPLELKVSRFGQFLGCTGYPECKHTERLELKKEPEPIGEACPACGEGQLVRRHGRYGSFISCSRYPECKYTRDEAPSTGIECPKCHAGEVVQKTSKRGKPYYRCNNPACDFLSFDPLLPDKCPLCGWNEVAKGRSGKRACTNPGCERYGGPKLEALNQRRTKSSSKTSGTAKNKVKDRAKASATWADLEPFITKAGLTPEQAEVARRTQGQQKQVAAVAKALNQPEEAVLKLFRQAMFKLRMEYGKARKEAVSA
(734) DNA topoisomerase 1 [Acidiphilium cryptum JF-5]
1
MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGDRQVAAIAKALKGADTLYLATDPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEITKSAVQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICEREAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVERGAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVGLITYMRTDGVQMAREAITAARQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFTLTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTVELADAAGTTLRATGSILAFDGFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEELGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEEKLDEVSDGRLDWRSVMRDFWADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDPRVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEGGEDEGDQLRDGMKLLGENAEGIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGVHPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHPKDGESVTARKGRFGPYVQHGKTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAKPAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPEAAAAKAKPAARKTARSGG
(737) DNA topoisomerase 1 [Nostoc punctiforme PCC 73102]
1
MIKRLLVVESPGKVKKLSQILGSDWKVLASCGHIRELSNEGDDSLGFVMDGSNVRCNYVPRDQRAKETIQKLKSAVRQVDEVVLATDPDREGETIAWHLKETLGLKEPKRVIYTEITASAVQSAIANPKKLDQNLIGAGLCRDCLDKLVGYKGSPLVWALNNGAKSVGRVQSATLHLICQRENEILAFVPQDYWSVWVDYAEGFRAFYKGTVDSAKDAADQETETNDDAKVGNSPETPESKRVLSEAEATRLVEEAQRHPHQVIHFEGKIVNRQPPPPFTTSSLQQAAGSKLRFAPDKTMIVAQKLYEAGLITYMRTDSVMLSPEFCASARKWLEQNDPQNVPHQVAKHRSSKSAQEAHEAIRPTDVFRPSVQLRLELPDDEFNLYVMIWKRSIASQCRAAQLRKTLVITQSGSLLWSARGQVIEFYGYARYWNNLSKDSVLPSLQQGQALKLENAGHEKKQTQPPPRYSEPKLVQLMERKGIGRPSTYAPTVATLKKRNYVELKKDHLQPTALGLEVDAFLLKALPDLLEAEFTAKMEDALDAISEGKNSWQHYLTSWNQNYFIPALSKAKTVVASSPKGKANVITERKYETSKTRCPECKNFLAKIPSTKVKKKYFLKCTKGCENVVLFWSDFNKTWQPPQTKTVQVENQQKPPVKMTAYPCPVCKKPLEEYSYIKEGQSKKMLRCCDPQARKDTKHKDVAYFSTPKGWWSPKFGELGVKS
(738) DNA topoisomerase 1 [Candidatus Solibacter usitatus Ellin6076]
1
MPKALVIVESPAKAKTINKYLGKQYVVKASLGHIKDLPKRDLAVDVEHGFEPRYEIIEGKKKLMGELRSAAKGVDQIYLAADPDREGEAICFHLQEELRSKKDGPAFFRVMFNEITKKAVEKAFEKPLQVNTNLVDAQQARRVLDRLVGYKISPLLWDKVRRGLSAGRVQTVALRVIVEREREIRAFQKKEYWTVDVDLLARTAPVLSTRLIKANDETPELPNQQTTDSLVAQLSGVDYIVKSVATREKRRNPVAPFITSTLQQDSSRKLRFSVKRTMMLAQRLYEGIEIGRDGAVGLITYMRTDSTRTSDDAISDVRHYIGERYGAPFLPPAPNVYKSKKEAQDAHEAIRPTSMAYSPEVVEQYLPEDEMKLYRLIWNRFVASQMMPALFDQTTIDVSAKAANGVEYTFRATGSVPKFDGFLKVYQEGKDQTDEDDEELKHRLPLVTEGEVLRLEAIRPEQHFTEPPPRYNEATLVKRLEADGVGRPSTYATILSTIQEREYVNKEAGRFTPTELGMVVTDLLLESFDDIFDVKYTARMEEELDEIEEGKLDWRAAMSEFYGRFDKDLKHAEEHMTDIKRMEKPTDLICEKCGRPLVIKWGKHGSFIACTGYPDFSSKSIESDLEKVQKDIEVRRQRALKKIELSLEKLRAKYPDRTITWGQDGEFLVIPSAPKIPKPMDAALKKLEKEIAVKRSEDRGKIEARLEKLQARYPQMKGFYDLDLRDTAEGVALTVRRKEEFCTYTRELTVDLPDLEGADLSEQGEEESCENCGRPMVLKKGRFGTFFACSEYPDCKTTRQIGGTQKKDVPLDEKCPQCDNNLVMKYGRFGEFTACSNYPTCKYVKQKTIGVKCPECSEGDIIERRSKKGKTFYGCNRYPDCTFVAWGKPVAEKCPECGSPYMIEKFLKSGAFWQCPNAECKHQVEAPAPVEVTS
(739) DNA topoisomerase 1 [Asticcacaulis excentricus CB 48]
1
MNLVIVESPAKAKTINKYLGKDYTVLASYGHVRDLPSKDGSVKPDEDFAMSWEVDAKASKRLSDIADAARKSERVILATDPDREGEAISWHVLEVLNKKKVLKEKVVERVTFNAITKASVQEAMAAPRQIDMELVEAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALKIIVDRELEIEKFKSEEYWTVDAEVSANSPPFTARLNVLNGKKLAKFDLENAEKAEAARKAISLSKFAVESVEQKPGKRTPPPPFTTSTLQQEAARKLGFSAQRTMQTAQKLYEGVDIGGETTGLITYMRTDGVFIDPAAIGEIRKAVGERFGSAYVPSEPRLYKVKAKNAQEAHEAIRPTSIFRRPETLRLEGDQARLYELIWKRTMAAQMEAARVEKTTIDLLNHDKSIGLRSTGQVITFDGYLALYEEGKDDETDEDGGRLPQLRTGTLVDVHDIKPAQHFTEPPPRYSEASLVKRMEELGIGRPSTYASILSVLRDRDYVRMDKNRFIPEDKGRLVTAFLDQFFSRYVQYDFTADLEEKLDLVSAGDLNWKALLREFWQDFHAKAGEISEFRVSEVLDRLNDALAPHIFPDKGDGSNPRACPTCGTGQLSLKTSRFGAFVGCSNYPECKYTRPVGNPENASEVAAASGDRELGRDPETGKVVALKIGRFGPYVQLGEAESKDDKPKRSSLPKAWPPASIDLDRALKLLSLPRKVGDHPEDGKPITAALGRFGPFIEHEKTYANLPSFDEIFEVGLNRAVVLLAEKRANAKGKASTVATLKELGAHPESGDAIQVMAGRYGPYVKCGKVNATIPKDTAPEDVTLEQALALIEAKGGVKKTAAKKTTAKKAAPAKKPATKKATTSKKAPAKKAKAEA
(741) DNA topoisomerase 1 [Candidatus Pelagibacter sp. IMCC9063]
1
MNLVIVESPAKAKTINKYLGSNYIVLASFGHVRDLPSKNGSVDTENNFNMVWEIDTASKKHIKEIADAAEDCEKIILATDPDREGEAIAWHVRHILEDKNLLKGKKVERVVFNEITKKAVVYGVENPRDLNIELVNAYLARRALDYLVGFNISPILWTKLPGSKSAGRVQSVALKIIVEREYEIELFKPEEFWTLNAVFKNSQNKEINSKLNIYDSKKVEKFSFKNKKAAENAVAEINKNEFKVKSIESKPFKRNPYAPFRTSTMQQDASRKLGFGASRTMQVAQRLYQGIDIEGETVGLITYMRTDGTDISLDAVADCRTFIKNEIGEKYLPSEARNYSGKKAKNAQEAHEAIRPTDITRTPNSLKSKLDKDQMRLYELIWNRTVSSQMESAEFERTAIDFTNQSSSMIFRANGSIQKFDGFLKLYQEVKDEDDKEKEDSDEDNILPEVVKDEILKIDKVLNEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASIISVLSTRNYVEVLNKKFTPTDRGKLITSFLNQLFTRYVDYNFTAGLEESLDDITTGKADWIEVLAKFWKEFNQNVLEVKELRTRAILDMMNESLGEIIFDKDNEGKIKRSCECGGELSLKTGRFGAFIGCSKYPDCKFTRPMSRIKAAEQDYLAEPKEIGKTEDDKNIVLKKGRFGPYLQVGNDEKEMKNVSIPKGISLDDIDLDKARFLASLPKVLGQYPENSMDITLNNGRYGPYVKCDKKSATLEAPEDIFSIGLNKAITMIADAKPGRRSSNEIKLIGEHPEDKKPVKVMKGSYGPYIKYKTINATIPDDKDPESVTMEEALDLIEKRLEYDSTKKGKKIKKKTAKKRKPKKKADKNKDEEK
(742) DNA topoisomerase 1 [Sorangium cellulosum So ce56]
1
MAKTLVIVESPAKAKTIKKYLGNGYEVFASKGHVKDLPKKQNAVDVQNDFAETYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIAFHISEEIKNPKLKVARVEFHEITKKGVDHGVHNPRKLDENLYDAQRARRVLDRIVGYDVSALVWSKLAFGLSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAKLASADGKKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQDATNYLHFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVVAKRYGKEFVPERPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLYKLIWNRFVASQMTPAVYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQEFAGEEESAGAAADGGAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPPGVITDQKFTQPPPRYNEGSLVRELEKRGIGRPSTYAEIISKVQQRAYVEKRDGGAFQPTLLGKFVVDGLVRSNLDIMDPNFTAQMEEELDAVGAGSLKREQLLKSFYKKFREQLDKSKKLAPWKPEAEKTDIVCDECGSMMLKKWGKNGWFLSCERYPKCKATRDLSDARGTAAVRETDISCDKCGKPMIIKTGRFGDFLSCTGYPACKNTRPVPLGVACPSCGGDLIEIRPRKKGGRTFYGCSNWNAEQKCEFKLWQKPVPVPCPQCGAKFVTRTAGKKAMLVCATKDCGFKQEIVEGEGEDGAADGAATPDAAAVVASAAPAPAARPAPAEPTPAGRPEAAPEGAGAAQGAAEKPARAVRARRTAS
(744) DNA topoisomerase 1 [Azospirillum lipoferum 4B]
1
MPGSNVVIVESPAKAKTINKYLGDDYTVIASFGHVRDLPARDGSVRPDEDFAMEWELGDRSKRHIDEIAKAVKSADRVYLATDPDREGEAIAWHLSELLREKHLTDNRDVQRITFNEITKSAVQAAIANPRDVSRELVDAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICERESEIEVFKPQEYWSIAVGFTTPAGAGFTASLTQLDGKRLDKFGLPNREAAEAAVAKILPQSFAVSSVERKQSRRNPSPPFTTSTLQQEASRKLGFGATRTMRTAQKLYEGVDIGGETVGLITYMRTDGVSLSQEAIDGARSLIGSQYGERYVPAQPRVYKTAAKNAQEAHEAIRPTDLQRRPDSVAGYLESDELRLYELIWKRTLASQMESAVLDQVAVDIANPSKDVVLRATGSIVVFDGFLKVYQEDRDDAAEDDQQERRLPAMDQGDALARGDIAQDQHFTQPPPRYSEASLVKKLEELGIGRPSTYASILQVLQDRNYVRLDKRRFIPEDRGRLVTAFLENFFHRYVEYNFTAELENQLDEISDGKIDWKTVLRDFWTAFDVAVNGTKDLTITQVLTTLDNELGAHFFPAATADGHDPRVCPVCREGRLGLKLGKMGAFIGCSRYPECRYTRPLAVANDENGEAQEGPRELGNDPETGLPVTVRRGPYGAYIQLGPAPTVAAPPEEPAVEEPAADGKKPKAKKKKKDEAPKPKRVSLPKGMAAADVDLDTALKLLALPRTIGNHPETGEEISAGIGRFGPYLKHGSVYKSLTPDDDVLTIGINRAVDLLAGAAKKASAPAKTLGDHPKTGKPITMGSGRFGPYVKHASVYASIPKGTEPDSVTLEQALELIDAKVAKDAAKKGKAPKDAEPAKAEGAEAEKPAKAKAAAKKPAAKKATKAKAAKDAPAEAAAPKKKTAKAS
(747) DNA topoisomerase 1 [Mycoplasma gallisepticum str. F]
1
MTNHSSKILVIESPNKVKTIKKYLTDDYEIVATVGHIRDLPKYTLGFNTEDFVPKWEIIQEKKPAKGVSATKKAKTVKKAVKNKKEIIDELVDKAKKADEIYLATDPDREGEAISWHVYDVLKEKGVNVNKCKRIIFNEISEKAVKNAIANPREIQKDWVSSQITRRRLDRLIGFKLSSLMKSKINADSAGRVQSIALKFITEREELINKFVPRFWWTLDVILKDGTELMLRKIDEKLKDKLGFKELEEVSGIDFNTKEDAELVKQHLSDKYRVYAIDTPKLKSSYPKEVYKTSTLQQDAINKLKWRSMKITSVAQELYEGVTIDDEQIALISYPRTDSTRLSPEYGKTVLDFVAKTYGKDYVATQSQLNGETKANKKQKAKVQDAHEAIHPIDISITPDSVKNKISSDQYSLYKLIWTRTVAHYMAAAVYELVNIRFINNNNKFYAVNNTLKFDGYKKIYTHYDDKDHLRKLDLNHFAIDKEFEAKDVLLNEHQTKPPARFTQATLIEALETEGIGRPSTYSTILDIVLKRNYAELVNGRYYKTTDLGQKLAFELDKNFPTIINKEFTKNMETTLDEIAQGTVNDVSYLQAFWNDFSEVLNEAKTNIVKKVEYIEGKNCPNCSSQLVRREGRYGPFVGCSNFPKCKFIEKSEQKAKEIVYEEGVKCELCHAKLIRRVAKKKGRNKDNTFLGCSNFPKCKYTKSLEPEKDETIRDSTII
(751) DNA topoisomerase 1 [Helicobacter acinonychis str. Sheeba]
1
MKHLIIVESPAKAKTIKNFLDKNYEVIASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKDLVKQIIELSKKASTTYIATDEDREGEAIGYHVACLIGGKLESYPRIIFHEITQNAILNALKTPRQIDMSKVNAQQARRFLDRIVGFKLSSLISSKVTKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDALFEPNLEAQLVSYKGNKIKAQELIDGKKAQEIKNELEKESYIISSIVKKSKKSPTPPPFMTSTLQQSASNLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARDKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSVILEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQNVVVACEKGEFKASGRKLLFDGYYKILGNDDKDKLLPNLKENDPIKLEELESNTHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQIRALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGESCPKCGGELVKKNSRYGEFIACNNYPKCKYVKQVENAHNEAKQELCEKCGGEMVQKFSRNGVFLACNNYPECKNTKSLKNTPNAKEMIESVKCPECGGDIALKRSRKGSFYGCNNYPKCNFLSNHKPIDKRCEKCHYLMSERIYRKKKVHECIKCKERVFLEEDNG
(753) DNA topoisomerase 1 [Acholeplasma laidlawii PG-8A]
1
MSDKVIIVESPAKSKTISSYFNDEVTVLSSVGHIRDLATSGKGGLGVDVDNNFEPTYKIITGKGKLITDLKKKTKGKEVLIATDPDREGEAIAWHIADELGLDLNEHNRIVFKEITKPAVMEAINHKRQIDLGLVNSQESRRILDRIIGFKLSAFLRDKIKSRSAGRVQSVALKLIVDLEREIEKFVPETYFTMHAHFNDHVADYVIPKDTRIGLEEATKIVETSTNPFLVSDITQKETKRNAKPPYMTSTLLQDGVNSLYMSSSRVMSVASELYQGIEINGQIIGLITYMKTDSNRLSKEFVNPAKAFIETNYGKEYVGFYKTNNKDSSQDAHEAIRPTDIHLTPEKIEQYLSKDQFKLYKRIYERAVGSLMAPAVFNNTKITLDSNGNIYTMDGSIQVFDGHLKVTGDKSKDKFLPEYKIGDKLNADLVEKIEKQTQPPARFNEASLIKALEANGIGRPSTYASIIKTIKARDYVIVDEKRFIPTEQGKLTVDTLNQYFNKIMKIDYTSNMESELDLIADGKVDHIQLLKDFYNKFMPILEAAQQNMEKIKPVVTDKICPLCGGNLVIRKSRYGEFYGCSNFPKCKHIEQMSE
(759) DNA topoisomerase 1 [Persephonella marina EX-H1]
1
MGDKKTKKIVIVESPKKAREIQKFLGKEYSVKATIGHFKDLPEKEMGVDLKTFKPKFVIKSKNHRKMLSEVKKLAENAEVYIATDPDREGYAIGYFMYEELKKKAKDIKRAEFHEITEKHVKDIIKKAPKFEQTNFGLFDAFLGRRVGDRIVGYTLSPIASKEIGGRFSVGRVQSPAVRLIVEREREIQQFKPTPYYVLTAILKKDDTQFVSYYEKQRLEDKELAKKIYEGIKTVRQAVVKDIKKKEVKQSPKPPFTTSSLQQTANSQLRFAPEKTMMLAQDLFENGLITYHRTDSVRISKEALTGIRKFIEKSFGKEYLPSKTRVYRSKNTQADAHEAIRITNFVDLDTQRKLVSEKGLTEDHFKLLKLIYQRTIASQMKDAVYDRTTALFDIGGYVFKTTGSVLKFDGYKKVYNIEDKEETQRLPDLKKGETVEKVDQKLEEKWTKPPGRYTEGSLVRKLEELGIGRPSTYATIIKTIKDRGYVVKEGGSLRPTEAAYHLIDYLNGKYNWVIDYDFTRRMEEFLDAVEEKKKDWKEFVEELYRKSVEGAKNVISKKMKDYALDLAKKHGKDISDIIDDPEKLKEFIDQHKETKPSEKQIAYARSLSEKTGLELPEDVLQDKEKIKRWINKAKKEAMKSYKLSEKQKAVLIKNGKEDLIDKPEKALKWLEMYFRKRRKK
(760) DNA topoisomerase 1 [Streptococcus suis ST1]
1
MATKTVSKKKTTTKKNLVIVESPAKAKTIEKYLGKNYKVVASVGHIRDLKKSSMSIDFDNNYAPEYINIRGKGPLINSLKKEAKNAKQVFLASDPDREGEAISWHLAHILGLDANDKNRVVFNEITKDAVKNAFQEPRAINLDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEISNFKPEEYWTIDATFKKGSKKFQASFYGIDGKKTKIENNEQVKEILARLDGDDFLVEQVERKERKRNAPLPYTTSTMQMDAANKINFRTRKTMMVAQQLYEGVSLGTGGTQGLITYMRTDSTRISPVAQAQAADFITERFGATYSKHGNKVKNASGAQDAHEAIRPSNVNLTPESIAKYLDKDQLRLYTLIWNRFVASQMAAAVFDTMSVRLGQNGIVFAANGSQVKFDGYMAVYNDADKNKMLPDMEQGDTVVRASTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVKLAAKRFEPTELGEIVNKLIVEFFPDIVNVKFTADMEQKLDDVEIGKEQWQKVIDGFYQPFKVELSKAEEQMEKIQIKDEPAGFDCDVCGHEMVIKLGRFGKFYACSNFPDCRNTKQITKEIGVTCPVCQKGQVIERKSKRNRLFYGCDRYPECEFTSWDKPVGRSCPKCDHYLVEKKVRGGGKQVVCPNGDYEEDKIK
(765) DNA topoisomerase 1 [Pelotomaculum thermopropionicum SI]
1
MSKTLVIVESPAKAKTISKFLGKKFTVKASMGHVRDLPKSQFGVDVKNGFKPKYITIRGKGDIIKDLRAAVKKADQVLIASDPDREGEAIAWHLQNLLEIDENESCRIEFNEITKQAIQKALQHPRPIDRNRVNAQQARRILDRLVGYNLSPLLWRKIKKGLSAGRVQSVAVRLICDREEEIQSFVPEEYWTLVASFVKTGEAPFEGRLIKFRDEKIDIPSKEKMQEVLENLKGARYTVEKVTRKEKSRKPPLPFITSTLQQEAYRKLNFTARKTMMVAQQLYEGLDLGREGTSGLITYIRTDSTRVSASAREEAQKYIVERFGARYAGRETPPVGPAGRKGKIQDAHEAIRPTSVQREPEQVKEYLTGDQYKLYKLIWSRFLASQMKPAVFDTTNIDIKAGEYLFRANGSVMKFPGFMKVYTESRDDEEKEEEKLLPELKEGEEIEARSLTPRQHFTQPPPRYTDASLVRALEEKGIGRPSTYAPIVETILKRGYVVRENKQFFPTELGMIVVDLLKKHFKEIIDIDFTAGMEESLDSIEEGELDWIKVLESFYGPFKNTLEKAENEIGHVQVAEEVTEEKCDRCGRSMVVKVGRYGKFLACPGFPECRSTKPLLEPVGAKCPRCEGELVVRRTKKGRKFLGCSNFPECEFVTWDQPSGTKCPECGGLMVEKKNAGKKGFLQCVSEDCGYKKTAGEKKAGKKNADTESMSAET
(766) DNA topoisomerase 1 [Acidaminococcus intestini RyC-MR95]
1
MANLVIVESPTKSKTIGRFLGKNYTVKASMGHLRDLPKSQFGVDVDHDFEPKYINIRGKGDLIKELKTLAKKADKIYLATDPDREGEAIAWHLGYLLGVDPESNCRISFHEITPHAVKEAIKHPAAIDMDKVDAQQTRRILDRIVGYKLSPLLWRKIAKGLSAGRVQSVAVKIICDRQKEIDAFEPQEYWTSSVTLTADKPSHKFTAEVTKKEGKKLVIHNEEEARTVTKELLNQSYAVASSAVKDRIRRPIAPFTTSSLQQEAVKRLNFTTKKTMMLAQQLYEGIALEKRTPVGLITYMRTDSVHLASVAVAEIRNYIGEVYGDAYLPKKPNVYSSRKNAQEAHEAIRPTSVMRTPDEVAPYLERDQLRLYRLIWERTVSCQMAPSVSEVTTLIINGGPYELRASGSVVNFDGFLTLMDKKELAGEKTKKVPHLKEGTPLTLISVDDAIQHFTEPPAYFTEATLVKELEEKGIGRPSTYATIIQTILSRGYVAKEAKKVMPTELGMTTIELLTQYFPNLIDVPFSAHMENELDAISEHKTKKETVLKEFYGPFEKELEIADREIPVKPQEVIVSDVKCEKCGRMMVVKTGRHGKFLACPGFPECRNTKPYYEKIGVACPLCGHDLIVRKTKTGRTFYGCSHYPECHFTSWDKPINETCPLCGHIMLEAVQRGGKVVHHCSNPECPNSGAKKSGLKKVSAKAALAKTEGTAEKTVKKTTAKKTTTAKKTAVMKTASTKKTASTKKTAVKKTGKE
(769) DNA topoisomerase 1 [Nitrosococcus watsonii C-113]
1
MSKNVVVVESPAKAKTIKKYLGKNFEVLASYGHVRDLMPKEGAVDPEHGFKMKYQAIEKNGRHVNAIAKALKSADSLLLATDPDREGEAISWHLLELLKEEGVLEDKAIQRVVFYEITSQAVNEAVAHPRDISLDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIDAFKVREYWTLEADAAAAKQPFVAKLTHLDGRKLTQFDIENKDQALALVERLTKAAAGELWVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSAKRTMSVAQQLYEGVDIGDGAMGLITYMRTDSVNLANEAVGEIRNFIAERFGQNSLPVKSRTFKTRAKNAQEAHEAVRPTSVYRVPEALKPYLKPEQFKLYQLIWRRTIACQMNHATIDAVAVDLDTQKAAPERGEDARGNIFRATGSTVVDPGFMAVYQEGRDDAKGEEEQRKLPPMKEGDRVALLQIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRDYTVLESKRFQPTDVGRVVNRFLTEHFNPYVDYDFTARLEDELDAISRGEKVWIPVLEEFWGPFSARIQEKEQNVSREEAVQARELGVDPQSSRPVSVRMGRYGPYIQIGSKEDEEKPRFAGLQPGQKMDAITLEEALALFKLPRELGFTPGGERVSVNIGRFGPYVKYDNKYVSLRGEDPHTIPLERALVLIEEKRQADANRVIKVFPDSGIQVLNGRYGPYVTDGERNVRVPKEQAPEELSLEQAQTLIHEAPVKRARRKAGSRKKAKG
(770) DNA topoisomerase 1 [Butyrivibrio fibrisolvens 16/4]
1
MAKNLVIVESPAKVHTIKKFLGSSYEVMASQGHVRDMPKSQLGFDPENDFEPKYITIRGKGELLAALRKEVKKADKIYLATDPDREGEAISWHLTHALNLQDKKVYRITFNEITKTAVKNSLKNPREIDMDLVDAQQARRMLDRMVGYEISPLLWAKVKRGLSAGRVQSVALRIICDREKEIEQFIPQEYYTLDVLLDAAGSKKPIVAKYYGDTSGKKDISDKESLDKIMESLKGASFNIASIKRGTREKKAPLPFTTSTMQQEASKALNFSIQKTMSVAQQLYEGVTVKGYGTVGLITYLRTDSTRVSDEAKAAAESFISSNYGDNYLSESAGNAKKNSGKVQDAHEAIRPANIELIPSEIKDSLTRDQFRLYQLVWKRFVASQMANAVYDTVSLSVSAKDQVFTASESSINFDGFMMIYTAADDEEESKTHPLAKLTEDTKLSFNSFEEKQHFTQPSPHFTEASLVKTLEELGIGRPSTYSPTITTLIKRHYITKEAKNLFVTELGEVVNSIMVDSFPIIVDDKFTANLELLLDGVEEGTVDWKSVVRNFYPDLEKAVKVAEEELAKVEIHDEVTDVICEECGRNMVIKFGPHGKFLACPGFPECRNTKPFLEKIGVPCPKCGGDVVIRKSQKGRKFYGCSNHPECDFISWSKPTTVKCPKCGTYMVEKGNKLVCGNDECRFVQSQN
(773) DNA topoisomerase 1 [Sulfobacillus acidophilus TPY]
1
MESPAKAKTISRFLGSRYQVKASMGHVRDLPKSQFGVDLERGFEPRYITIRGKGPLLKELKDAAKKTDRVYLATDPDREGEAISWHLAESLGIPLAEARRIEFHEITKDAVTEAIRHARPIDMHLVDAQQARRVLDRVVGYQLSPLLWRKVRPGLSAGRVQSAALRLLVDREDQIQAFQPEEYYTVTLTLDTQPVMTAQYAGPLGEKGRLSPVDAQTVVGRVKKGQTVHVESVKTRERRRFPALPFTTSTLQQEASRRLGFSVKRTMSIAQQLYEGLDVQGEGTVGLVTYIRTDSTRVADVAEAEARQFIESQYGTAYWKGLGAAKRPEKERPGVQGAHEAIRPTSVMRHPDRLKASLTRDQLRLYRLIWERFVASQMAPLVYDATTVELSVGEDRFRAHGAVVKFAGFTVLYQESAADDTKAANEDDAGQGPLPVVQEGQTLTATAVEAEQHFTEPPPRFTEASLVKTLEELGIGRPSTYAPIIDTLLQREYVQREQKRLIPTPLGRLVVELLQKYFPEIVDISFTANVENQLDRVESAELGWREVLTDFYRPFAEELAKAEQDLEKVAIPVEETDEVCDQCGRPMVVKYGRFGKFLACSGYPECTATKPFVEKTGAVCPKCGDQLVVRRTRKGRTFYGCHSYPACDFVTWLRPTEKTCPRCGSSMALRKKGRQETLTCLKEGCGYEEQAQ
(779) DNA topoisomerase 1 [Dehalogenimonas lykanthroporepellens BL-DC-9]
1
MKKHKKLVIVESPAKARTLARFLGSNYSLKASLGHVRDLPKSTLGVDIENDFKPKYINMRAKSAVIKDLKEAVKKSDEVVLATDPDREGEAIAWHLVEAIGLGATPYRRVVFHEITKDAIDKAFKAPRDLNMDLINAQQARRVLDRLVGYKLSPLLWRKVRRGLSAGRVQSVALRIIVDREREIESFIAVEYWTIEGEFSPKNKPGEKFKAGLIGVGGKKKISIPDAETAEIIVLDLKTAEHKVDSITEKPASRRPSPPFITSTLQQEAWRKLKFSAKQTMALAQQLYEGLSVGEEGNVGLITYMRTDSTHIAQSALADTRKFIGEQYGEAYLPKTARHYSKKIKGAQEAHEAIRPTDVKRTPERLKPYLEPNQLKLYRLIWQRMVTSQMADARFLNTTVDIVSFGTKSKEKYIFRTQSSLNVFDGFMVLYTEGKDDDIEQNTAKIPDLKDGEALNLTDIVKDQKFTQPPPRYTEATLIKTLEQFGIGRPSTYAPILSVVQQRDYVEKTKGVFKPTELGMIIRDILVQQFPEVIDAGFTAQMEESLDKVAEEGYNWVTVINDFYTPFNNDLEAAQAQLEKVPLPVEESEETCPKCHQAKLLIKIGRYGKYMECPDCQFRQSFRIRTGVMCPDCPENAEIIGRYSKKGKLFYGCEAFPKHKFAINARPVAVPCPECGGLQAEYNNKRIKCTNKTCKNAK
(782) DNA topoisomerase 1 [Acidithiobacillus ferrooxidans ATCC 23270]
1
MAHQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDLQPKEGAVDTEHDFAMRYTPIERNERHVDAIAKALRGADKLWLATDPDREGEAISWHLVELLRERQLLGDKPTQRVVFHEITKKAVQEAIAHPREIAMDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASRLQHAGSAFTGRLTHWQNKKLEQFDIADGDQAQAIRSGMEDDLGRQALRVREVERKSRQRQPAAPFTTSTLQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRTFIDGYYGSEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPESLQGVLERDLWRLYDLVWKRSIACQMAPARLDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDESNRILPPLDVGDEPLVLGIDPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQRRFHPTDLGRVVGRFLINHFERYVDYGFTASMEDELDAVSRGEKQWQPVLSAFWSPFRALLDEKANVSRAEATSEALEEACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAEPVGRDCPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQPKSSGVTCPQCGEGELVEKRSRYGKVFYSCNTYPKCTYAVWGPPVARPCPRCGWPIMIEKSGKRLGEQLACPQSECAFHFPANASDAEIAALLPGYSPPPPREKRAPPAKKAAPARKTTAKTAKKPATEATAVAAQKTAKAKTTSAAAKKPAASKARGPSAGEGKTSPSRKRAAKGASDS
(786) DNA topoisomerase 1 [Staphylococcus carnosus subsp. carnosus TM300]
1
MADNLVIVESPAKAKTIEKYLGKRYKVIASMGHVRDLPRSQMGVDVEEDFEPKYITIRGKGPVVKELKRHAKKAKKIFLASDPDREGEAIAWHLANILELDENAKNRVVFNEITKDAIKESFKTPRGIELNLVDAQQARRIVDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLIIDRENEIRNFKPEEYWKIEGNFRYKKSTFSAKFLHYKNKPYKLNNKDDVKFITDQLDGNEFEVTKVTKKEKKRYPANPFTTSTLQQEASRKLNFKARKTMMIAQQLYEGIDLKKQGTVGLITYTRTDSTRISAGAKAETKEFITEKYGKDYVSQRKAAAGKQGDQDAHEAIRPTKTLRTPAEMKEFLTRDQYRLYKLIWDRFVASQMAPAVLDTVAMDIEQNDVKFRANGQTIKFKGFMTLYVESKDEEEEKNSKLPVIAEGEKVVATDIEPTQHFTQPPPRFTEARLVKTLEELKIGRPSTYAPTLDTIQKRNYVKMESKRFVPTELGEIVHEQVKEYFPEIIDVDFTVNMETLLDKIADGDIKWREVVGNFYGGFEKDVERAEQEMEKIEIKDEPAGEDCEECGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKEIGVKCPKCDDGQVVERKSKKGRVFYGCSNYPECDFISWDKPVGRSCPKCDHYLVERKKGRSSQVICSNCDYKEEVQK
(791) DNA topoisomerase 1 [Bacillus subtilis subsp. spizizenii TU-B-10]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPLKSEADVKDILSQLKGNKYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQAYGKEFLGGKRKPAKKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMSVDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVGLDNKRFVPTELGQIVLELIMEFFPEIINVEFTAKMEKDLDNVEEGNIEWVQIIDNFYTDFEKRVKKAESEMKEVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGEGNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVECDYKEEPQK
(793) DNA topoisomerase 1 [Aster yellows witches'-broom phytoplasma AYWB]
1
MKSKVIIVESPTKTKTLSRFLNDDFLILSSKGHIRDLSLKGKDRMGIDIEKGFIPKYSIIKEKDNIVETLIQKTKGKEVLLATDPDREGEAIAWHLSQILNLDSQKTNRIVFREITKEAVLKALQQPRKINELLVFSQETRRMLDRIIGFKLSRLVRRLKSQSAGRVQSVALKLIVDLEEKIKAFVPEEYYIITAFFKDFQAEYQNPYKGKIKAQEAFTIVQQIKDKSFLVKELKQQETKKFPKPPFITSTLQQEAIKSLNMTSNQVMRVAQKLYEGVDILGESKGLITYMRTDSQRLADIFVKDAQKLIKKQYGEEYLGTYKNSKTPQSQDAHEAIRPTDLSKTPESLAPHLDKYENKLYKLIYQRTLASLMTPAIFQKTQVFFEVANHLFLTESLIKTFDGYQKLLQDGDKDKIIPSFKSNETYLPQEIQNLQKFTNPPSRFSEATLIKTLEKLNIGRPSTYSQIIFTLKKRIYVDLVEKRFVPTEQGILTTKNLELFFKQIIDVKYTAKMEENLDKISSGLVNKKELLQEFYDAFKQLYQIADQKLEKTKDIETDQKCNLCNAPLLIKKGRYGNFLGCSRFPECKNIVSLKEKTSSLETNPDMKTDQKCNLCNAPLLIKKGRYGNFLGCSRFPECKNIVKIQKN
(794) DNA topoisomerase 1 [Rickettsia bellii RML369-C]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVIPDENFSMKYDISEKAGKYVDAIIKDAKKAESVYLATDPDREGESISWHIAEVIKEKNKVKSDDFFKRVAFNEITKKAITHAIENPRKLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMLNSNNELFTAKLTHINDQKLEKFSITNDKEAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVDEIRKLINKDYGDKYLPSSPRIYKSKVKNAQEAHEAIRPTNINYIPNDLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVNATLASENKEYLARANGSTIAFDGFYKVYRESIDDEAEEENKMLPPLKEQEHLKTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYATILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKSALGNFWNGFNHNIESVNKQNITEIISYVQQALDYHIFGENKDSKVCPSCKTGELSLKLGKFGAFLACSNYPECNFRKSIVSGNDNNEADGEAKDIVNENKVLGKDKEGIEIYLKKGPYGPYIQYGEQVDSKIKPKRSPLPAGLNQNDITLDMALKLLSLPLKIGNHKESGEEVLVGYGKFGPYIKYMGKFISIPKKYDFLNLSLDDAMKLIEEKLNAIAAKQPNPLNMDEVTNLVDKKIKVKKTKK
(796) DNA topoisomerase 1 [Novosphingobium sp. PP1Y]
1
MQLVIVESPAKAKTIEKYLGKDFKVLASYGHVRDLPPKDGSVRPDEGFEMDWELYGDKQKQVRAITDAAKVSDRLILATDPDREGEAISWHVLELLKKRRALPKDVQRVTFNAITKDTVTKAMQAPRELDQDLIDAYLARRALDYLFGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDREREIEAFRPQEYWSVAAHMEQDGTPFTAKLVAFEGQKLDRLSLGDEGIAMRAKAAVEQGAFKVENVETKPHRRNPQPPFTTSTLQQEASRKLGFSASQTMRVAQSLYEAGAITYMRTDGVQMDPSAISACRKAISDRYDGHYLPEKPRHYETKAKNAQEAHEAIRPTEFTRDRFGSGDEARLYDLIFKRAMASQMASAALERTTITLRDGTGRNELRATGQVVKFPGFLAVYEEGRDQKDDDEESGLLPMMRSGDAPAKKDVTAEQHFTQPPPRFSEASLVKRLEELGIGRPSTYAATIQVLKDRNYVRTEKNRFFAEESGRLLTAFLERFFERYVAYDFTAGMEEELDDVSGGRHAWKELLEAFWRDFKPKSDEVMERKPSEVTEVLDEFLSDYLFPPKDDGSDPRACPKCADGRLALRGGRYGAFVACSNYPECKFTRKFAQPGGNGETADDEELGKHPETGEEITRRVGRFGPYIQLGEGKEAKRASIPKDIDELTLDWALKLLSLPREVGKHPETGKEIVANIGRYGPYLLHDGKYGKLRSTADVFETGMNAAVSILAEAAQGGGRGQRAKAEPIKVLGKHPTSEGEIKVLAGRYGPYVTDGTTNATLPRDQKPEELTAEQAIALIDAKAAKGPAKGKKKASAKKAPAKKATAKKAAGKSGEAKTATKKAPARKASVTKTSNDTSEQDGEVPWDVDA
(797) DNA topoisomerase 1 [Solibacillus silvestris StLB046]
1
MADYLVIVESPAKAKTIERYLGKKYKVKASIGHVRDLPRSQMGIDTENNYDPKYITIRGKGPVLQELKTAAKKVKKIYLAADPDREGEAIAWHLATALNIDINSDCRVVFNEITKEAILESFKHPRPINMDLVDAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSVSLRLIIDRENEIKSFEPEEYWSIDASFEKNKKQFDAFYYGNGKEKVKLTNEQQVKDILKGIKGSEFEVMNVIKRERKRNASPAFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIELSKKEGAVGLITYMRTDSTRISDTAKTEAKSYIETKYGKDFIAGEQKQAKAKANAQDAHEAIRPTSAMRTPEELKAILSRDQLRLYRLIWERFIASQMSPAVLDTVTVDLQNNDVLFRANGSQVKFAGFMKLYIEGTDDQEEETNKLLPEMEIGDKVKSLEIEPKQHFTQPPPRYSEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVQLDAKRFVPTELGEIVHQATLEFFPEIINIEFTAQMEQNLDEIEEGITQWVNVIDEFYKDFEPRVKYADEVMEKIEIKDEPAGEDCEKCGAPMVFKLGRYGKFMACSNFPDCRNTKAIVKPIDVKCPSCETGEIVERKSKTKRIFYGCNQYPECDFVSWDKPISRPCPKCSALLVEKKLKKGVQIQCTNSECDYEETPSQ
(798) DNA topoisomerase 1 [Methylobacterium populi BJ001]
1
MKVVVVESPAKAKTINKYLGRDYEVLASFGHIRDLPAKDGSVDPEADFAMVWELEDRGSKRVSEIARAIKGAEKLILATDPDREGEAISWHVIEALSARKALKGIPVERVTFNAITKASVDAAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWSIVATLATEAGGVFEARLVGADGKRIQRLDVGNAEEAAAFKRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQKLYEGVDVGGETVGIITYMRTDGVDMAPEAISDARRVIGREFGDDYVPGAPRKYSVKAKNAQEAHEAVRPTDMGRLPKQVARYLEPEQAKLYELIWTRTIASQMESAELERTTVEVTASVGPRRIDLRATGQVVKFDGFLALYQEGKDDEEDEDSKRLPAMAAGDPLKRERIASTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFKRYVEYDFTASLEEQLDRVSNAEIDWRSVLRDFWRDFSAAIGGTKELRVAEVLEALNGLLGPHIFPEKADGGDPRACPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSASGVEGEGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFVQLGEASSEKGAEKPKRSSLPKGTSPGSVTLEIALRLLSLPREVAKHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRPSSDPGRALGPHPDGAALVVKAGKYGPYVSDGSVNATLPKTMAAESLTLEQAIELINAKRASGGGKKPVRKTATRARTATKAADGAEAKKPAVRKTASKTASKSTTKAAAKPAAAKKAAAKTKAS
(799) DNA topoisomerase 1 [Borrelia hermsii HS1]
1
MQQRKLIIVESPTKATTIKKYLDNSFSVEACIGHIRDLPNSAKEIPDEYKKFEWANLSIDYQNDFKPLYIIPSNKKTVIEKLKNLIKEQDEIYLATDQDREGETIAFHLKEVLQIKNYKRMVFHEITKSAIIDSLNNTREINMNLVNAGETRRIIDRLYGYTISPLLWKKIAYGLSAGRVQSVGLQLIIEKEMARINFKKANYYSITLECKHNKNDIQIKTTLEKIENKNVAESKDFVNDTGVLHNPDKTIAIDKTLMNVLTKELKKTKEIEVISIETKETKQAPPKPFITSSLQQEVNRRLKIGTKQIMNYAQKLYERGYITYMRTDSYNIAKTAREKIKNIIKQKYGEEYIETNDRVYVKVKMAQDAHESIRPSEMFTPPEQIQIESETAREIYKIIWDRTIESVMKDAIKKVIKITLKYENLTFKASFTNLIFDGFLKNNKESYENNIMDFSLIKEGDKFIILDIKPEEHETKPPLRYTEASLVQKLEKEGIGRPSTYSTIISTLFEREYIFKQNNTLIPTIKGAAVTNLLKKYFPVLIELKFTSHMEENLDKIAIGTLDKIKYLNKFYNGEEGLKNTVNKIEPIISPEEFRIVHEYNNDEKFNYKINIGKFGPYLIFNGNNYSINVTTPLENLYKEDEIKKIIAEKEIQPNILGVDPVTGLNVIYKNSKYGGIVQLGEDVYAPQEFTKTGKPKKPKIIKAKKVSTKNIEYENLTLELALKLLSLPKVIGEYPQTHEKIIATTGIFGDYIKTENNSIICPLKKDMKAYDITLEESIKLLDAKLEKNGIIVKTIPLSKNKVGNKIYVYRQNDKLYAKIKRKKVDLPTNIDLDQIDAAYVCGLM
(800) DNA topoisomerase 1 [Sebaldella termitidis ATCC 33386]
1
MAKKLVIVESPSKAKTIEKILGKGYEVEASYGHVIDLPKTKIGVDIENKFEPHYQVIKGKGDILKKLKDKAKKADAVYLASDKDREGEAIAWHISNYIKVPAKTKRIEFNEITKSAINNAIKHPRNIDENLVNAQQARRILDRIVGYKISPLLWKIINKNASAGRVQSVALKLICDLEDEIREFIPQKYWEVTAITDKGIELGIYEIAGKKVDRIFDEKVMKKLKKDLAKKNLEVFKIKVTKKTQRPPLVFKTSTLQQLASSYLGFATSKTMRVAQQLYEGLSINGENVGLITYMRTDSTRISNESMADAGKYIEKNFGKEYVGKYMPAKAKGNVQDAHEGIRPTDINLSPDSIKDSLSAEQYKLYKLIWERFLVSQFSAMKYDQMQINAKNGDYVFRGTINKVTFDGYYKVFKDEDEIKTADFPEIKEGDELVVKELNIKDGMTKPPARFSESSLVKKLEAEGIGRPSTYASIIETLKTRNYAELVDKRFIPTVLGYEVKSELEKHFEKIMNIKFTANMEEELDEIENGSIKWEELMANFYKGLEVDLTKFEKEIQDLQDRRIEADIMCANGTEAMILKTGRFGKYLICESNPDEKVSLKGIQIPKEELEAGKIIVKDKVAEKESEKKGVPTDHFTKDGARIFVKKGRYGEYLESEDYENDEIRMPLPYKIKQEIKKGTAKMQDGMYIIHEELEKMLAEDQRIIEEAGLCEKCGRPFEIKIGRFGRFLACTGYPDCKNIKKIPKK
(807) DNA topoisomerase 1 [Oceanithermus profundus DSM 14977]
1
MSGKTLVVVESPAKAKTIKKILGPNYEVKASVGHVADLPQRDLGVDLEHDFEPKYVVKKEKQKVVSDLKKAAGKAERVLLATDPDREGEAISWHVARLLDLDPQKPLRVHFHEITPRVIKEAVKKPTPIDQNLVDAQQARRVLDRLVGYNLSPVLSAQFRQRALSAGRVQSVALRLVTEREAEIEAFVPKEYWTLTGTFDAGARFAAELYEIDGKRVLDKKKENFLITSEAQARAVEAEVRAVPAWQVAAVERKEKRRHALPPFTTSTLQQAASSRLGWGAGRTMRVAQRLYEGVNLGPEGPVGLITYMRTDSVRIAPEAIAEARAFIPEQYGPDYLPPKPNYYRGKKQGVQDAHEAIRPTSVQRRPEQVKPFLSDEEFKLYDLIWRRFVASQMTPAVYDQTAITVEGGKFTFRAAGSILKFDGFLRVWGRDQQEEQPLPEVDAGAPARLVELASEQHFTQPPPRYTDASLVKKMEELGIGRPSTYAPTIDTLERRAYVERQGRALKPTELGKRVIGFLVEHFPRVVAYEFTAQVEDRLDEVEEGKQAWPAVVREFYEPFTEELSRVPRKTCPVCGRPLEIKVSRYGQFLGCTGYPECTYTEPLEEKKEAEPIGEDCPKCGAPLVRKWGRYGSFIACSAYPKCDYTRDEAPSTGITCPKCKEGEIVQKTSRRGKPYWRCNKQGCDFLVFDPPTEQTCPKCGWIMVKKGKREVLKCSNPDCEDYAYPNFKNRPPRGKAGGGRKKTRKKGAAKKKAGPKATWADLEPFTAGLEEAERRLVVQVEGEGVPLEQAAANLGVTAEEAAKLHKRAMFKLRMAYGRAKIKPR
(809) DNA topoisomerase 1 [Lactobacillus acidophilus NCFM]
1
MPTKAKSKSKTKKRKKILVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDNYKPKYISIRGKGDTIKELKSEAKKAKEVYLASDPDREGEAIAWHVAHALDLDENAKNRVTFNEVTKDAVKESFKHPRSIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWSIDAEFSKGKDTFKSSFYGIDGKKKELPNNDAVKEVLAKIDKRKNFEVENVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKEGTVGLITYMRTDSKRTSPVAQQEASKFLHENYGAEFAAKSQRHFKNQEDAQDAHEAIRPTSVYRTPESLKSVLTTEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVMFRTTGSKMKFPGFTKVYDNQQEKSVDLPDLQEGDKVKMTKSDNKQHFTLPPARYTEASLVRALEENGVGRPSTYAPTIDTIQRRYYVKLDGRSIVPTELGEIVDTLIEEFFPDIANVDYTAHLENELDEVEDGKKEWVHVVDEYYQPFKKELTKADSEIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKEIGVVCPKCGKGEVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKHSKKGPVVLCPNGDYKEEPQEGETDK
(814) DNA topoisomerase 1 [Buchnera aphidicola str. Ua (Uroleucon ambrosiae)]
1
MSKSLVIVESPAKAKTINKYLGNEYIVKSSIGHVRDLITRKFKKPTHKSQKYSQSYSLNNKQKTYFIENIGIDPYKDWKAEYSILPGKEKIISELKNIAHKVDHIYLATDLDREGEAIAWHLKEVIGGDSTKFSRVVFNEITKHAIKKAFKNITKINMHRVHAQQARRFMDRIVGYMISPLLWEKISRGLSAGRVQSVAVRIIAEREDIIKKFIPEEYWKLNVSFVLKNQNKIIMDVTHFNNKKFRPNNQNELNIAIEEIKKSSFFIKKFEKKIIYKQAPAPFITATLQQSASLILGFSVKKTMFLAQKLYEEGYITYIRTDSCYLSLNAINKVRKYIKKFYGDAYLSNKYYIHTNKKHSQEAHEAIRPSDIKVKNINTNTINLDAEKLYLLIWNQFIASQMKPAQYQFITIKIFSHLFQLQKQLKIVLFDGWTKMFKEKNENITQIPIIDIGSILNIDNIIINQKFTKPLPRFTEASLVRELEKKGIGRPSTYSVITSKIQERGYVTIKKNKFYAEKMGSILTIRLKKSFSNLIDYNFTANMEKKLDQIAENKLSWINVLNSFFKDFSEKLDQAKKNPEEGGMELNNIVFTSIKCPTCFKKMGIKNAITGVFLSCLGYQDNLKKRCKQTINLIPLNDVLKKKQNNEVTSGFTKLINKCEKCNMFMDSYFINKNIQLHICINNPSCIGYKVEKGNFKIPIWLSKTVECDKCYSNMLLKKGPFGKFFICVNIKCKNTRKILPNGEISDPKLEPIPFPELLCKKSNASFVLREGVSGIFFAASTFPKSRETRSPFIEELAKFQYLLPKKIYYLSKAPIVDDKGNKTIVCFNRKNKEYYVTSKKKGKFTGWSAVFIKNKWCVINQ
(815) DNA topoisomerase 1 [Lactobacillus johnsonii NCC 533]
1
MPTKRKNKKNLVIVESPHKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGVDVEHDYEPKYISIRGKGDTIKELKSEAKKAKYVYLASDPDREGEAIAWHVAHALNLDPKEHNRVAFNEITKDAVKNAFKNPRTIDMDIVDAQQARRVLDRLVGYSISPILWQKVKKGLSAGRVQSIALKLVIDRENEIKNFKPEEYWTIDADFEKGSEKFKGAFYGIKGKKQELPNNEAVQDVLKRIDKRKNFEITKVVKKERRRQPAAPFTTSTMQQEANKRLGYRTRRTMRIAQSLYEGVNLGKGSVGLITYMRTDSKRIANVAKHEASKFIHEEYGENYAAVKPQHFKNDADAQDAHEAIRPTSAFRTPASVKEYLTTEEYRLYTLIWSRFIASQMTPAVYDTVRADIEQNDVTFRTTGSKLKFAGFTKVYDNQKEKSNELPELNEGDKVKLKKTDDRQHFTQPPARYTEASLVRTLEENGVGRPSTYAPTIDTIQKRYYVKLEGRSIVPTELGEIVDKLIEEFFPDIVNVDFTAQLENDLDGVEVGKKNWIKVVDEYYKPFSKELDKADQQIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKIGVTCPKCGKGEVIEKKSKRNRKFYGCSRYPDCDFVSWDQPIGRNCPNDGHFLVQKKNKKGLVILCPNGDYREEPEEN
(820) DNA topoisomerase 1 [Neorickettsia sennetsu str. Miyayama]
1
MNVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKGSVDVTESFEMLYKLTDTGETVVPQLIKDVKKATALYLATDPDREGEAISWHLVEVFKENDVLPKDVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSISPVLWKKLPGSKSAGRVQSVALRILCDRENEIGLFTPEEYWTVTVNMTDGEALVLPTQLSHMNGEKLERMSIRRAEEAEKIVEEISGLPFLVEEIKKKELKQKPSPPFITSTMQQTASTILGFSVKKTMSLAQKLYEGIEIGGVIEGLITYMRTDATHLSVESVDAIREFIQEKFGQEYLPASPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAITSSQNIVFVSQDKKFKTSASASLLIFDGFNAAFSHGKNKNKNQDVIDFIKKHKEGAQVKVGDVLLTQNFTEPPHRYSEAGLVKHLEELGIGRPSTYATVVSVLQERGYASIVNKSFIPESRGRLVSEFLVHFFSKYVEYHFTAELEDRLDKVADGTIFWLDVIQDFWDSFHSNVEEVEKVPITEVLAFVNGALARQKLVSAEVKVGDKCPKCEKGYMHLNVSRYGVFLGCTDYPVCRFIVNSYSTDNDTEYPKQIAQDISLHKGPYGIYLKCKGKNSSIPKDVDPVSIDEEFAHKIASLPKILGKHPIDGKEIKMGLGPYGLYLFWNAKYYNLQFSQMDEMTLDQAVQFMEDYVSHDKSLLRVLGSHEGEEIQIRDGRYGPYIKYSKMNVPIPKGESPESLSLETAILLIEKKKNTSKSARKVTTKRKVFTKEKK
(821) DNA topoisomerase 1 [Thermus scotoductus SA-01]
1
MVVESPAKARSIQKMLGPGYEVRASLGHVADLPERELGVDVERDFAPTYEVKKDKKPVVEALKRAAKGKRLLIATDPDREGEAIGWHVARLLGRDPKEPLRVEFHEITPRVVRQAVQNPRPIDQNLVDAQQARRVLDRLVGYNLSPLLSLEFRKRALSAGRVQSVALRLLVEREEEIEAFRPEEYWTLEGVFALGQDRTLPASLYEVEGKRLWAGQGEKEGKLHLANEAQAQALAEEVKGPSYRVVQVETRERRKSPPPPFTTSTLQQAASSRLGYTASRTMRIAQRLYEGVDLPEGTVGLITYMRTDSVRVSPEALQAAREVIQRIFGLEYLPEGPRVYRNRKEGVQDAHEAIRPTDVRRTPDSVRKYLSDEEYRLYDLIWRRFVASQMRDALYDQTVVLLKDEGEKPRFTFRASGSVLKFEGYLKAWGRGDEGGVAQAVNEGQEVEAEPPLPLVAEGTGAELLEVKAQQHFTEPPPRYTDATLVKTMEELGIGRPSTYAPTLETLEKRGYMVRKGRTLLPTPLGRQVTHYLKERFPQVVAYEFTARMEDRLDQVEEGKAPWPKVVWEFYEPFLGELSQVPKKTCPRCGRPLELKVSRFGQFLGCTGYPECTYTEPLERKKEAEPIGEACPKCGRPLVRKEGRYGSFIACSGYPECDYTRDDGEPTGHTCPKCGSQVLEKRSRRGKPYYKCENNACDFLSFYPLLDQTCPSCGWPLVKKGEGACMNPACPVHDPKLVPPPKASSRAASSSGDLASRGRRSSRRKAARAGESRTGAKAKAKVQEPSPPKPPKDWEELKPFLGELTPEERQAAEALALGEVLSPEAAKLAQRAIFKLRMKKGRARKEAVT
(836) DNA topoisomerase 1 [Bacillus anthracis]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(837) DNA topoisomerase 1 [Bacillus anthracis]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(838) DNA topoisomerase 1 [Bacillus anthracis]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(839) DNA topoisomerase 1 [Enterococcus faecalis V583]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQEKWVEVVDRFYKPFEKELTNAEEKIEKIQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVTCPVCHEGQVIERKSKKNRIFYGCSRYPECDFTSWDKPVGRPCPKCGQYLVEKKVKGGKQVVCINGDYEENVQK
(840) DNA topoisomerase 1 [Enterococcus faecalis V583]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQEKWVEVVDRFYKPFEKELTNAEEKIEKIQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVTCPVCHEGQVIERKSKKNRIFYGCSRYPECDFTSWDKPVGRPCPKCGQYLVEKKVKGGKQVVCINGDYEENVQK
(841) DNA topoisomerase 1 [Enterococcus faecalis V583]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQEKWVEVVDRFYKPFEKELTNAEEKIEKIQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVTCPVCHEGQVIERKSKKNRIFYGCSRYPECDFTSWDKPVGRPCPKCGQYLVEKKVKGGKQVVCINGDYEENVQK
(843) DNA topoisomerase 1 [Lactobacillus sanfranciscensis TMW 1.1304]
1
MVESPAKAKTISKYLGRTYTVVASKGHIRDLPKSRMGIDIPDDFKPDYISIRGKGDTIKMLKAEAKKAKEVFLASDPDREGEAIAWHVSHVLNLDVNDKNRVTFNEITKETVKDALKHPRTIDMNLVDAQQARRIIDRLVGYSISPILWKKVKKGLSAGRVQSVALWIIIKREREIQAFNPEEYWTIDSIFKKGRSKFKASFYGVDGKKFPLGNNDDVQNVLKRLDAKADFEITDVKKREKKRQPPRPFTTSTLQQDANKKLHFKTGRTMMAAQQLYEGINIGKEGSQGLITYMRTDSTRISAGAKLEAAQFIHDEYGPEYALNHPRKLKLPEGAQDAHEAVRPTSVMRTPKQIEKYLTKDQFKLYNLIWSRFVASQMTPAIVDTETIKVVQNGVEYRANGSKLNFEGYLKAYSAGKKKDNILPDLEIGDHITLDNNVPNQHFTQPPARYTEASLIKALEENGVGRPSTYAPTLMTIQKRYYVKLDARRFVPTELGEIVNKLIEEYFPEIVNVDFTADIEGKLDDIEEAKLRWVKLVSEFYQPFSKEVSYAEKEMEDVQIKEPLAGFNCNICGSPMVEKMGKYGKFFACSRFPDCRNTQTIVKEIGVICPKCHEGQVIERKTKKNRLFYGCSRYPDCDFVTWDKPIGRDCPKCGHFLVNKKVRGGWQVICPEGDYEENAIK
(847) DNA topoisomerase 1 [Anabaena variabilis ATCC 29413]
1
MSTLVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASEIPATVKGEAWAQLGVNVDADFEPVYVVPKDKKKVVTQLKEALKDADELILATDEDREGESISWHLYQLLKPKVPTKRMVFHEITQEAIKKALKDCRNIDEQLVRAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVNKERQRRAFREGTYWDLKAYLEQSKSPFTAQLTTLAGTKVATGSDFDASTGRITAGRNVVLLTETEAVALQERLTGKTWNVSEVEERPVTRKPAPPFTTSTLQQESNRKLRLSARDTMRIAQNLYEQGYITYMRTDSVHLSEQAIAAARNCVEQLYGKQYLSPQPRQYTTKSKGAQEAHEAIRPAGSTFRTPQETGLGGRELALYDLIWKRTVASQMADSRQTQITVQLQVEDAGFRASGKRIDFPGYLRAYVEGSDDPEAALEDQEVILPSLKVGDHPDCKNIEAVGHETQPPARYTEATLVKTLESEGIGRPSTYASIIGTIIDKGYSQLVNNALIPTFTAFAVTDLLEKHFPDIVDPSFTSKMEQTLDDIAEGEAQWLPYLKKFYLGDQGLETLVRERESQIDAGKARTVELENLDAKVRIGKYGPYIEVENGDGVVTASIPKDLTPADLDPKQVEIILRQKTVGPDQLGRHPETGEPIYVKIGAYGPYVQLGDKSDENPKPKQASLPKGVTPENISLETAIGLLSLPRTLGTHPATGGKIQASLGRFGPYVVHDQGKEGKDYRSLKASDDVLTISLERALELISEPKKTRGSTSSKSKAALRELGTHPEDDAPINIYDGPYGPYIKHGKTNVGLPEGTSVEDVTLATALELLSAKASTAKTTRKTSKTSTTKSKSTAKSSSTATKKKGA
(849) DNA topoisomerase 1 [Trichodesmium erythraeum IMS101]
1
MSTLVIVESPTKARTIRNYLPSDYRVEASMGHVRDLPPSAEEIPEKFKGEKWAQLGVNVESDFEPIYVVPKDKKKTVKELKDALKEVDELLLATDEDREGESISWHLLQLLKPKVPTKRMVFHEITPEAIRRAIDNCRNIDEQLVRAQETRRILDRLYGYTLSPVLWKKIARGLSAGRVQSVAVRLLVNRERQRQAFKRGGYWDLKASLEQEKTPFESKLVTLGGTKIATGNDFDENTGKIVEGRNVILLDEAHAEALKEQLQHKPWTVNSFDERAVRRKPSPPFTTSTLQQEANRKLRMGARQTMRTAQNLYEQGFITYMRTDSVHLSDEAIAAARSCVEKMYGPEYLSSEPRQYTTKSKGAQEAHEAIRPAGKTFRTPQETGLKNQEFALYDLIWKRTVACQMADSRQTHITVNLQVEDAGFRSNGKRIDFPGFLRAYVEGSDDPEVSLENQEVPLPAIKQGDHPACTEIEVVGHETQPPARFTEASLVKTLESEGIGRPSTYATVIGTIVDRGYAKLQSNALVPTFTAFAVTTLLEKHFPEFVDVKFTARMEQTLDDISMGEAQWVPYLKKFYFGESGLDTQIKEQENQIDPKLARTIELDNLDANSEMTYRICIGKFGAYIEAENGENIVKASIPEDLTPSDLDPEQIEKLLKQKTEGPQELGIHPEEDKSIYIMTGRYGPYVQLGDDSEGSKRKPKRASLPKGVNMEDVTLDLAVGLLSLPRTLGTHPETGCKIQANLGRFGPYIVHDQGKEDGKDYRSLKVKDDVLTITLERALELLAQPKRSRRGSAKAVLPLKDLGKHPEDGETVGVYDGRYGLYVKHGKVNASLPKDMSVEDVTWEKALELLHAKASSKKSARGRKSTKSKAENN
(852) DNA topoisomerase 1 [Desulfovibrio vulgaris DP4]
1
MGKDLIIVESPAKVKTIKKFLGGKYVVQASVGHVRDLPTNEIGVDEANNFAPQYRVIDGKQKVVDTLREAAAKADTVYLAPDPDREGEAIAWHVAALIEGKADNIKRIQFNEITARAVREALENPRDLNRALFDAQQARRVLDRLVGYKLSPLLWKKVKRGISAGRVQSVALRLIVDRESERRAFTPEEYWLFRAMFAKNVPGATPTSPDPQYAPFKAELAKIDGKKAHVADADAANALEDAMRGKPFVITAVERKKRERQPQPPFITSTLQQAANQRLGYSAKRTMNIAQRLYEGVELGEMGTVALITYMRTDSVRVSDEARDAARAFVTETWGADFCPAKPRQFKTKGSAQDAHEAVRPVDVNVTPDSVKHLLPPDQFQLYRLVWSRFVASQMAPARFDDTTVAIACGPAEWRAKGERMLFPGFLAAMPQKEEGDAELPPLQEGETLHPVSVEKEQKFTQPPARYTEASLVRELEERGIGRPSTYASIISTLIDRDYTRLEDKHFVPTDLGATVCDLLARHFTTLMDVGFTAQMEDSLDKVAEGGLDWVELLSRFSADFNPTLESAAKAMETVKGGLPTNVTCPECGKPVVVKFGKAGPFLACTAYPDCKFTSNFSRDEKGDIVIEQRAREELEAVGTCPECGKDLVVKKARTGSRFIACTGYPDCRHTEPFSTGIACPREGCDGQLVEKSSKRGKIFYSCNRFPKCDYALWDWPVPGPCPVCGSPLLVKKSTRAKGLHIACPEKTCRYTQELPDDEG
(853) DNA topoisomerase 1 [Halanaerobium praevalens DSM 2228]
1
MAKKKKKLVIVESPAKAKTIKKFLGKDYKVEASMGHVRDLPKSKLGIDLESDFEPNYITIRGKGKTLNKLRKAAKKSKEVYLATDPDREGEAISWHLAYALKLSDQENNRIEFNEITKNAIQNAIKNPRNINKDLVDAQQARRLLDRIVGYRLSPLLWKKVRKGLSAGRVQSVAVKIICKREEEIRDFDEEEYWSLEVELKNDENQTLKADLYRIDNKKYNLATQEEVEQVVEAIKKEEFEIIKVKKRKRKRNPKSPFTTSTLQQRASTKLNFTAKKTMYIAQQLYEGIDIGSSGTVGLISYIRTDSTRLSNEAKKGAKDYILAEFGTDFLKKKKEKSKKNANAQDAHEAIRPTDTQRTPEKIKKHLSKDQFKLYDLIWKRFIASQMSSALYQNISAQFKVGEKYKFRVSGSRLLFPGHLILTGKEKEKDIDLPVLTEGEKYKLIKTNPEQHFTTPPPRFSEASLVKTLEEEGIGRPSTYAPTLSTIESRDYVKKEGRYFEPTELGETVTKLLTEYFPDVTDVEFTAELEKNLDEIENGNKDWKQILRDFYEPFYQRLENARENMESVNIVEETDEVCDKCGSPMVVKYGRYGKFLACSSYPECKNTKPYLVRTGVDCPDCEEGEIIERTSKKGRTFYGCSNYPDCNFMVWNKPVEKPCPKCKSLMVEKTTKAKGKHHKCTNKECGHIEKVD
(855) DNA topoisomerase 1 [Flavobacterium johnsoniae UW101]
1
MAKNLVIVESPAKAKTIEKFLGSDFQVESSYGHIADLPSKEIGVDVENGFKPKYEVSPDKKALVTKLKSLSKNAETVWLASDEDREGEAISWHLAEELKLDTKKTKRIVFHEITKSAILKAIDNPREIDYNLVNAQQARRVLDRLVGYELSPVLWRKIKGGLSAGRVQSVSVRLIVEREREIQSFNAVATYSIVAEFVNEAGKAFKAKLPKNFNTKKEAEDFLNKNIGSKYKVADLETKPTKKSPTAPFTTSTLQQEAARKLYLPVGITMQLAQRLYEAGLITYMRTDSVNLSKEAMDAAQAEIIKSYGEEFSKPRIFATKSKGAQEAHEAIRPTDMSRHTVNIDRDQARLYDLIWKRTLASQMSDAQLERTNVKIEADNHDELFTASGEVLLFEGFLKVYLEGHDDDEEEQEGMLPALKVNEKLANNYITATERYSRPPARYTEASLVKKLEELGIGRPSTYAPTISTIINRNYVEKGTLEGQERNYTQLTLQNSKVGEKLLKENTGSDKGKLVPTDIGTIVTDFLVKNFGNILDYNFTAKVEQDFDEIAEGNIDWAIMMQDFYNKFHPNVKEVEANAERESGERILGKDADGRQVSVRLGKFGPMAQIGEADDEDKKFASLMADQNIGNITLEEALNLFLLPKNLGEYKGEEVEVSNGRYGPYVRHGSVFISLPRGEDPLNVTKERAKELIDEKALADAPIAVYKGEAVQKGVGRFGPFIKWNGLFVNVSKKYNFDNLSQADVEELIEDKLQKNIDKVLHNWEEEGIVVEKARWGRSVILKGKIKIELSKDVDATKLTLAEVQEMIEKKAPAKKTAAKKTTAAKKTTTAKKAPAKKK
(857) DNA topoisomerase 1 [Alkaliphilus oremlandii OhILAs]
1
MTKSLVIVESPAKAKTIEKFLGKNYVVKASVGHIIDLPKSKLGVDIDNNFEPQYITIRGKGPVLKEIKTLAKKSKNVYLATDPDREGEAISWHLARALGIEASDDCRIEFNEITKNAIKSAIKKPRPINQDLVDAQQARRVLDRLVGYQISPLLWKNVRKGLSAGRVQSVATKLIIDREEEIKNFKPEEYWTLSLKIKTKNNENFEIKFQNDNLGNKEIHTEAEVDRILNHIQNHEAIVTSVKKGEKKRNPNLPFTTSTLQQEAANKLGFSTKKTMSLAQQLYEGIDIGKSGTVGLISYIRTDSTRISQESSESCKNYIHENIGESYYHSETKERKENKGKKNIQDAHEGIRPTDVYRHPDLIKGFLSKDQYTLYKLIWQRFVASQMAPAVYDTLNVEFDINKVIFKATGSILRFEGFLKVYSYANVSENINIPDLAEGEVVTVLEQMPKQHFTQPPGRYSEATLVKTMEDLGIGRPSTYSPTISTILSRGYVEKEGKSLTATELGYIINEILEDYFSKIIDTNFTAKLEQSLDYIEEGTQDWKKLISEFYEDFKVMLLNAEEHMEEINLVEESDEKCSKCDSVMLIKHGRYGKFLACSNYPECEETKPFLYKIGVSCPKCESGDVIEKRSKKGRLFYGCSTFPDCRFVSWNRPTGKKCPTCGDILVYKKTKKSEKNICINKECGFEEEIEN
(860) DNA topoisomerase 1 [Oceanobacillus iheyensis HTE831]
1
MSDYLVIVESPAKAKTIERYLGKKYTVKASMGHIRDLPKSQTGVDVENNFTPKYITIRGKGDVLKELRKAAKKAKKIYLAADPDREGEAIAWHLAYILGVDPSSNCRVVFNEITKEAIKESFKHPRAIDLDLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALKMIIDREKEIQNFKPEEYWSIDAKFQKDKEIFDGSFYGINGKKVALKNEQDVKDIKQQLNGKKFAVDKVKKRERKKNPALPFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKKSGGITGLITYMRTDSTRISNTAKDEAKNYIVDNYGEKYLGKQASTKNKEGAQDAHEAIRPTSALRDPKNLKNILSRDQFRLYKLIWERFVASQMAPAVMDTMTVHLLNNNIEFRATGSKIKFKGFMKVYVEGNDDNKKTEDKLLPELEEGMEVDSKEIKPNQHFTQPPPRYTDARLVRTMEEIGIGRPSTYAPTLDTIQRRGYVTMDNKRFIPTELGEIKCDLMIEFFPEVVDADFTAKMEDDLDSIEEGNIEWKQIIDSFYKDFKVRLDKAEDEMEKVEIKDEPAGIDCENCGHEMVYKMGRYGKFLACSNFPECRNTKPILKEIGVDCPKCEEGNVVERKSKKKRTFYGCDRFPECDFVSWDKPIARKCPKCESMLVEKKNKKETQVQCTNCEYKEVAQT
(861) DNA topoisomerase 1 [Clostridium cellulovorans 743B]
1
MGTNLVIVESPAKAKTIRKYLGKNYVVEASMGHVRDLPKSQTGVDVENNYEPKYITIRGKGELLDKLRKQAKKSEKIYLATDPDREGEAISWHLSKVLKLSETEKCRIEFNEITKTAIKAAIKSPREINMNLVDAQQARRVLDRLVGYGISPILWRKVKWGLSAGRVQSATLRMICERDKKIKEFIPKEYWTIEGIFNSTDDTKNSKEKLNLKLHNFKNEKIEIDTKEKADEILNIIKSGNYTVSKVKKTERIKNPLPPFITSTLQQDAYRKLNFTTKRTMSIAQQLYEGIEIKGKGSVALITYMRTDSVRISDEAQKSALEFINTSYGTEYVPSEPRIYKGKKNIQDAHEAIRPTYIDITPDKIKGDVKDEIYKLYKLIWERFVASQMKSCVLDTVSVTVDNSGYNFKANGSTVKFDGFMKIYSYGTEGDESLTTIPKVQEGEMLSCIQIDGLQHFTEPPARFSEASLVKTLEENGIGRPSTYAPTIATLLSRKYIEREKKTLVPTELGIIVDNIMCEFFNQIVDEEFTANMEERLDDIELGDSDWRKIVNEFFTPVKAEIEKAEIELAKITIEDEVTDIQCEKCGRNMVIKHGKFGDFLACPGYPECENTKPIVEEIDTPCPKCGSKIVVKKSKKGRKFFGCSTYPNCDYVSWYEPSSKKCNQCGSIMLKKYNKTNGNYLECSNSDCKSKEIIQEETE
(864) DNA topoisomerase 1 [Caldicellulosiruptor hydrothermalis 108]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQEIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGKEYLPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTPDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVRKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRVIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPKCGSLMFEKGRKGNRKLVCSNENCAYEEKIGEKGE
(866) DNA topoisomerase 1 [Francisella cf. tularensis subsp. novicida 3523]
1
MAKNLVIVESPAKTKTIKKYLGNEFEILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKAAKDAQNIYLATDPDREGEAISWHVQEVLKSARLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVDAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLIEFNNNKVEQFTFTTAEDAENAKVDILKDANGFLIVDGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIQAKYDKDMLPAKPRVFEKKSQNAQEAHEAIRVTAANRTPESIKQFLTSDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHKFRVTGTVIVDAGFLKIYNVEKDEDDKDSDDEQTLPKFEKGERITLNDVITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQREYVEVDKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLSVLNNFWHPFIERINKISEDVSRKDVVQEELDEDCPECGSKLSLRLGKNGRFIGCTNYPTCKYTRPVDSDPKEVAKEEPVVVEDRKCPKCSSDLHIKQGRYGKFIGCSNYPECKHMEPLEKPKDTGVVCPKCNKNHIVEKKSRKGKVFYACAGFPKCKNAYWYPPIKEECPKCHSPILLHKTTKKDGEQKACPNSECDYAVPFEAK
(868) DNA topoisomerase 1 [Streptococcus pseudopneumoniae IS7493]
1
MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTIDAIFKKGTKQFQASFYGVDGKKLKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMAVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWQRVIDAFYKPFSKEVAKAEEEMEKIQIKDEAAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQIVCSKGDYEEEKIK
(869) DNA topoisomerase 1 [Bacillus amyloliquefaciens LL3]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLSSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFKPEEYWTITGSFLKGKETFEAGFFGKNGKKLPLKSEEDVKAVLAELKGNKYTVDKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAVEEASAFIDQAYGKEYLAGKRKAAKKNENAQDAHEAIRPTSVLRKPAELKAVLGRDQLRLYKLIWERFVASQMAPAVLDTMSVDLSNNGLTFRANGSKVKFAGFMKVYVEGKDDQLEEKDRMLPDLKEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQIVLDLIMEFFPEIINVEFTAKMERDLDHVEDGETEWVQIIDSFYTDFEKRVKKAEAEMKEVEIEPEYADEDCELCGSRMVYKMGRYGKFMACSNFPDCRNTKPIVKQIGVKCPKCHEGNIVERKSKKKRVFYGCDRYPECDFVSWDKPIERKCPKCENMLVEKKLKKGIQVQCVECDYKEEPQK
(872) DNA topoisomerase 1 [Methylomonas methanica MC09]
1
MSKSLVIVESPAKCKTIEKYLGKDFQVLASYGHVRDLIPKEGAVDPEHGFAMKYQVIDRNQRHLQEIGKALKNADTLYLATDPDREGEAISWHVFEHLKEKKLLKDKQVLRVVFHEITKKAVTEAIEHPTELSLTMVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRMIVERELEIEAFKTREYWSHTADASAQGQPFKAKLTHFNGEKLTQFSITDETQANQVKQALLDAGDGQLIVAKLEKKQRSKNPAPPFITSTLQQEAARKLGFTTKRTMMVAQQLYEGIDLGGETVGLISYMRTDSVNLADEALADIRALIAEKYGAGNVPKEPRQFKTKSKNAQEAHEAIRPTSVQRLPEQVKERLTVEQFKLYDLIWKRTVACQMIHATLNLVAVDLNCGSDKNVFRATGSTVTNPGFMMVYLEGVDDSKEATDDQDRLLPPMEEGRPVVLNDVTANQHFTEPPPRYSEASLVKALEEHGIGRPSTYATIISTLQNREYVTIDSKRFYPTDVGRIVNKFLTEHFTKYVDYDFTANLEDDLDAVARGEKDWIPLMNDFWRPFTQLISEKEESVQRKDVTQESIDEQCPECGSPLSIRLGRNGRFVGCTNYPTCSYTRNLGEDSAAATAEPEVVEGRVCPKCASPLVIKTGRYGKFVGCSAYPTCKHIEPLEKPQDTGVECPQCKKGSILKRKARSGKIFYSCSEYPKCSYALWDAPIKESCPDCHWPILTLKTTKRRGTEKVCPQKECKYATPYEGDPEDVNGPG
(874) DNA topoisomerase 1 [Thermosipho melanesiensis BI429]
1
MEKKKKVIIVESPAKAKTIEKILGKNFKVISSKGHVRDLPPKKFGVDLKTFEPEFEIIPGKEKVIEKIKKETEGKEVLIASDMDREGEAIAWHLSNILNLSGKNRIIFTEITPNTIKKSVENPREIDIKKVNAQLARRILDRIVGYKISPLLWKIIKGAMSAGRVQSAALKIICDRERKRFLFKPKEFYKVSIEIKKVKANLWGISGKKIKQENITEEIANDIKETVKEVILEKISEKERKKSSPLPYITSTLQQDAATKLGFPVSKTMQIAQALYEGVDTKEGHIAFITYMRTDSTRVSEEAKEMAKAFIEKKFGENYLGTTKKGKKKKKNVQDAHECIRPVNVEITPEIAQDLLNKDMYKLYKIIWKRFVASQMKEATYKDKTYIFKSGKYEFRTTISHRIFDGFEIIYPEKETTEKAVQLNEGEKYKVSKINVEKDATKPPSRFTEATLVKTLEAEGIGRPSTYATIISTLLQRKYVVKEKKELVPTLLGFVVEDFLTKKFPEIVDKKFTALMEEELDKIEEGEKKWKEVLNEFYSKFSKDLLNAQKEFYTINYETDLKCEECENTYKLKIGKYGLYLNCESCGKNKSIDNTLNAVIIKNNAYIQKAIEKNIKETVSENSCPKCGGHLTRKKGKFGYYFKCDNCDFTVSGYKIAAGRCPKCSSVVVMKRSKNNKIYWACSNPDCDYMSWNEPK
(875) DNA topoisomerase 1 [Cyclobacterium marinum DSM 745]
1
MPKNLVIVESPAKAKTIEGYLGKDFKVTSSYGHVRDLPKGENAIDIKNKFQPTYEVTSDKKEVIKELKKLVKGADTVYLASDDDREGEAISWHLKEVLKLKDENTKRIVFREITKSAITKALESPRSIDYDLVNAQQARRILDRLVGFELSPVLWKKIKAGLSAGRVQSVAVRFIVDREREIDKFKPTVSFKITALFDVEGKTLQAELPKKFQSKGEAEEFLKKCLEADFSIKSLETKPAKKSPAPPFTTSTLQQEASRKLYFSVAQTMNIAQKLYESGKITYMRTDSLNLSDDALKDAEKEIKSAYGDEYHKKRKFKSKSEGAQEAHEAIRPTSFSEHDAGKDRNEQRLYELIWKRSIASQMADAQLEKTNVSIAISNVDQTLSASGEVIKFQGFLKVYLESTDDEEEEETTGKGLLPPLTVGQVLQLIEMKGRQSFTRPPARYTEASLVKKLEEMGIGRPSTYAPTISTVQKRNYVVKESRDGVQRKYIEMTIGDGQFKEAEKTETTGTEKNKLFPTNIAMVVNDFLVEHFPNVIDFSFTAKVEKEFDHIAQGDQPWEEMIQNFYGNFHSKVELTENIKRTDVNSSKELGIDPKSGKVVIARLGKFGPLVQIGDAEDEDKRFASLRKGQFIESITLEDALELFKLPRDLGTFEDKKVVAAIGRFGPYIRHDSKFVSLGKEYDPLSVTLDEAIQLIKDKREADAKKHIKSFDENPEIQVLNGRWGPYIKMGKSNFKIPKDKEAESLTYEEVMKLIETQGDAKKNKPKKTAAKKAPAKKKAKK
(880) DNA topoisomerase 1 [Helicobacter pylori F32]
1
MKHLIIVESPAKAKTIKNFLDKNYEVIASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKELVKQIIELSKKASTTYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPRKIDMSKVNAQQARRFLDRIVGFKLSSLIASKITKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDAYFESHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYTISGIIKKSKKSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARNKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSIVLEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQSVVVACEKGEFKASGRKLLFDGYYKILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVMEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYVKQTENANDGAKQELCEKCGGEMVQKFSKNGAFLACNNYPECKNTKSLKNTPNANEIIEGVKCPECGGDIALKKSKKGSFYGCNNYPKCRFLSNHKPINKRCEKCHYLMSERIYRKKKAHECIQCKERVFLEEDDG
(882) DNA topoisomerase [Megamonas hypermegale ART12/1]
1
MASMGHLRDLPKSQFGIDVENDFAPKYINIRGKGDLIKSLKKEAKKSEKVYLASDPDREGEAIAWHLSHILGIDEHEKCRIVFNEITKPAIQEAVKNPKEINIDRVDAQQARRMLDRIVGYKLSPLLWKKIRKGLSAGRVQSVTVKLICDREKEIQKFESEEYWTVDFKFKKKPRSSMFGAELVAIDDKKLMVSAKKEDVKIASKAQADELCSDIEKVTFKVTEIKKRQRHRKAPAPFTTSSLQQDAARKLGFTSRKTMMIAQQLYEGISLGKKGPTGLITYMRTDSTRISEIALNEARNYIEENFGKEYLPEKPYIYAAGKSSQDAHEAVRPTNIALSPATVEEYLSKEQLKLYKLIWQRFLGCQMLPASYDVMSVTIKGDKYLAKATGSQLKFAGFTAVYNDSDNKKKKMSSCQICKKAMNYLFKN
(886) DNA topoisomerase 1 [Streptococcus agalactiae A909]
1
MATTTKTSTKKTSKKKSATAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINDLKKEAKKAKKVYLASDPDREGEAISWHLAHILDLDKEDRNRVVFNEITKDAVKNAFVEPRQINMDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFQPEEYWTIDGSFKKGTRKFNATFYGLDGKKFKLSNNEDVKTVLKRIKTDEFLVEKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMIAQQLYEGLSLGTAGHQGLITYMRTDSTRISPLAQNEATEFITNRFGANYSKHGNKVKNASGAQDAHEAIRPSSVNHTPESIAKYLDKDQLKLYTLIWNRFIASQMTAAVFDTMKVNLTQNGVTFIANGSQVKFDGYMAVYNDTDKNKMLPDMEEGESVKKVNTNPEQHFTQPPARFSEASLIKTLEENGVGRPSTYAPTLETIQKRYYVKLAAKRFEPTELGEIVNSLIVEFFPDIVDVTFTAEMEGKLDEVEIGKEQWQKIIDEFYKPFEKELAKAETEMEKIQIKDEPAGFDCELCGSPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVICPICQKGQVIERKTKRNRIFYGCDRYPECEFTSWDKPIGRTCPKSNDFLVEKKVRGGGKQVVCSNEKCDYQEEKIK
(889) DNA topoisomerase 1 [Streptococcus pyogenes str. Manfredo]
1
MGTKTTTKPKTGTKKSTTKKKSTAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHILGLDPQDNNRVVFNEITKDAVKHAFVEPRQIDMDLVDSQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENKIKAFVPEEYWSIDGLFKKGTKKFQATFYGINGKKTKLDNNNDVKEVLAKLTNEDFLVSKVDKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIHLGENGTQGLITYMRTDSTRISPVAQNDAAQFIINRFGANYSKHGNRVKNTSGAQDAHEAIRPSSVNHTPDSIAKYLNKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLEQNGVIFVSNGSQMKFDGYMAVYNDSDKNKMLPEMAEGETVKKISTSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVAFTAEMEGKLDQVEIGEEQWQHVIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGHPMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPVCHKGQVIERKTKKNRIFYGCDQYPDCEFISWDLPIGRACPKSGDYLIEKKVRGGKQVMCSNETCDYKEEKIK
(894) DNA topoisomerase 1 [Brachyspira murdochii DSM 12563]
1
MSDTTTEAKVKKTAGRKSKKESKKKKLVIVESPAKAKTINRYLGSDYLVMSSMGHLIDLPRSRLAIDVDHGFEPEYITIRGRAKILNDLKKEAKKAEEVLLAADDDREGESIAWHIGNKIRGVNSAVPIKRIVFHEITKDALKEAIDQPRDIDISKVNAQKARRVLDRLIGYNLSPLLWEKIKRGLSAGRVQNVALLIICNREDEIETFVPVEYWTFGVFLKHKNKEFLADLQKYKGEKPDLKTKQDVEDIMEHLKDKTYTVSSIEVKDRLRNPTAPYTTSKLQQAASSALGYSASKTMQVAQSLYEGVDIAGEATGLITYMRTDSVRISPVAQEQAREFIGKEYGSNYLPAEPPAYSVKKNAQDAHEAIRPTNVFLTPDSIKEYLKTDQYKLYKLIWERFVSSQMLPAKMKNTRAIITAGDCEFSLSSSKIEFDGFMKVLTIDKEDKEKASKMPNLSKDDVCEFVENNPQQHFTTPPPRYTDASLVKILEESGIGRPSTYAPTIKTIISRHYVQRKGKQLVPTELGKLVNELISENFPELVNINFTADMESKLDKIEDDNIEWNNILKEFYPHFLDTLKTATENINNMKDFFNEETDFICEKCGKKMIKRLGRYGYFIACSGFPECKNTKGISFGICPKCGGDITLKRSKRGREFYGCSNYPKCDFVSWDKPLQEPCPKCGGLMVEKNIKNKGLFKVCIKEDCGYSEEIKEDEE
(900) DNA topoisomerase 1 [Sphingobium sp. SYK-6]
1
MKLVIVESPAKAKTIEKYLGGDYRVLASYGHVRDLPPKDGSVDPEHGFAMAWENYGDKARQLKAITDEAKKADELILATDPDREGEAISWHVQEVLRAKKALPERVERVTFNAITKATITEAMKHPRALDDDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLIVEREREIEAFVSQEYWSVTALLEQGGQRFDARLVRWRGEKLDRLSIGKEGDALAAKADVEAGRFTVSSVETKPATRNPPPPFTTSTLQQEAARKLGLSASETMRVAQQLYEDGAITYMRTDGVQMDESAISAARNAIAKRYDGGYLPDKPRHYQTKAKNAQEAHEAIRPTDFSRESAGSGVHAKLYDLIFKRALASQMASARLERTAVELTDGTGQHVLRATGQVVLFPGFLALYEEGRDDPVGRQGAGDGEDEESRLLPALKAGDQPAKKDVRADQHFTQPPPRYSEASLVKRLEELGIGRPSTYASTIQTLKDRDYVRIEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEEELDEISGGRAQWQQVLEAFWRDFKPKTAEIMEQKPSEITAALDEYLAPMLFPDKGDGSDPRLCPLCHDGRLSLRGGRYGAFIACSNYPECRYTRKFGQPGGADGDAAGGNEELGTHPETGEPILRKSGRFGPYVEMGSGKEAKRASIPKDLPNGELTLDWATRLLSLPRTIGDHPETGKPITASLGRYGPYLAHDGKYARLASTAEIFETGMNAAVAKLADAANRGGARKAAEPLKILGAHPRTEAEIRLMEGRYGPYVTDGTTNATLPKTVAPDALTLEEAAQLIDERAAKAPAGKRKGKAKSSAGKSGAAKKTTVKGKAPSKAKSKAPAAAE
(901) DNA topoisomerase 1 [Paenibacillus terrae HPL-003]
1
MADSLVIVESPSKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFNPKYITIRGKGSILKELKDARKKVKKVYLAADPDREGEAIAWHLAHALDLDDTADCRVVFNEITKQAVKDAFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIILDRENEINEFVPEEYWTITAKLAIKDSTFEAKFHQLRGEKKELSSEADVQEVLEAIGKSSYKVRDVKEKERLRNPSPPFTTSSLQQEAARKLNFRASKTMSVAQQLYEGVDLGKEGTVGLITYMRTDSTRIAVSAQEEAKEFIIQKYGEAFVPESPRQYSKKAANAQDAHEAIRPTSALRDPETVKPFMSRDQFRLYKLVWERFMASQMASAIMDTLSVDIEAGETIFRAAGSKVRFPGFMKVYVEGNDDGKTEEDKLLPPLKSGDKLKKESVEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLETIQKRGYVAIEEKKFFPTELGELVIEQMEEFFPEILNVEFTANMEGDLDHVEEGEGDWVKVLSDFYESFEKRLEVAEEEMKEIEIKDEESDVICDKCGSPMVYKLGRFGKFLACSAFPDCRNTKPIVKDIGINCPTCGEGHVVERRSKKGRIFYGCDRYPECDFVSWDKPSIKPCPSCGGLMVEKRTKQGTKLNCTVCDHSEMLEDSDEGVETS
(903) DNA topoisomerase 1 [Eubacterium eligens ATCC 27750]
1
MHKYLVIVESPAKVKTISKFLGANYKVMASQGHVRDLPKSQMGVDIEHDYEPKYITIRGKGDILAALRKEAKKADKVYLATDPDREGEAISWHLAAALKLEDKDIYRITFNEITKNAVKASLKEARKIDMNLVDAQQARRVLDRVVGYGISPLLWAKIKRGLSAGRVQSVALRMICDRENEIDEFIPEEYWSMEAVLNIKGEKKPLIAKFYGDENGKIEIKNGAQMQDILDEVKKSDFSIESIKRGEKVKKSPLPFTTSTLQQEAAKTLNMSTKRTMNIAQQLYEGVDIKGRGTVGLITYLRTDSTRVADEAKVSSREYISQNYGEKYIPQEANAKKDDKKIQDAHEAIRPTDLNLSPAIVKESLQRDQFRLYQLIWKRFVASQMAPAVYETTSVKIMAGKYRFSVAASKVMFDGFMSVYKNDDDNEENNTLAKGLDENSELSLEDVNGVQHFTQPPAHFTEASLVKALEEQGIGRPSTYAPTISTIIARHYVIKENKNLYISELGNAVNNIMITAFPTIVDVKFTANMESLLDGVAEGTVEWKEIIRNFYPDLKVAIDEAEKELEHVKIEDEVTDVICDKCGRNMVIKYGPHGKFLGCPGFPECHNTKPYLEKIGVPCPKCGKDVIIKKTKKGRTFYGCDGYPDCDFVSWQRPSEKKCPKCGGYMVEKGNKIVCADETCGYVENKNDKEQ
(905) DNA topoisomerase 1 [Chlorobium chlorochromatii CaD3]
1
MASSVAALSAKNKTLIVVESPSKAKTINKYLGSNYTVFASVGHIKDLPKKEIGLDFEHNYSPRYEIIPGKEKVVKQLKKLATEASNILIATDPDREGEAIAWHIANEIEHAKAPVARVLFNEVTKKAILEAIEKPRHIDLRLVHSQQTRQGLDKIVGYKISPFLWKVVLRGLSAGRVQSVALRLICEREEEIERFVIQEYWTIAADFLTANKESFRARLVRLDGDKPEITNVEQAEAIAAIAKKGNYSVREITPRIQQRKQPLPFTTSLLQQAASNQLGFGAQRTMRTAQQLYEGIELGAEGAMGLITYMRTDSTRISPEAVGEARNYIERNFGKDYVGAGSSGKPGKNAQDAHEAIRPTSLLKTPEQVKPYLSADQFKLYELIWKRFLAAMMAPAKIEQTKVDVEEQSGKFLFRANGSRVLFPGFMRVYDDQQELAYEAQTSTKEEVENEMVVKLPEKLAVNDPLGLGALEQKQSFTRPPARYSEASLVKDLDHFGIGRPSTYASIFSTLQDRRYVALEKRKIMPTDLGRDVAKILVANFPELFNVGFTAFMEDELDKVASGDDAYEKVLDSFYKPLTSALALRSATPLIPQNNEAETCDKCGTGKMILKWTASGKFLGCSNYPKCKNIRTISSNREKPASTGVHCPSCEDGEMVLRKGRLGPFLACSNYPKCNTLLNLNKQRHIEPPKTPPVVTDMACPKCGAPLYLRSGKRGLWLGCSKFPKCRGRLAWTALEPAAQERWERVMAAHQKAHPPVTLKMVDGSTVSMTSSIDDIIMKADAAGLIAPAMDLVPEAEG
(906) DNA topoisomerase 1 [Coprococcus sp. ART55/1]
1
MIRITGNLQKGQIAMAKNLVIVESPAKAKTIKKFLGSNYEVIASNGHVRDLPKSQMGIDVDNDFEPKYITIRGKGDILAALRKAVKKADKIYLATDPDREGEAISYHLMKALKLENKDYKRITFNEITKNAVKNSIKQARDIDMNLVDAQQARRVLDRLVGYKISPVLWAKIKRGLSAGRVQSVALKLVCDREKEINDFIPQEYWTLDANLTGGKLKKPITFKFTGDGKNKEEISGRAALDEILSGLQDGEYVVKSIKESERNKKAPLPFTTSTLQQEASSKLNFATSKTMRIAQQLYEGVDIKGRGTIGLITYLRTDSTRISEEAVAAADKYITDNFGEIYIGDSNGRAKTDKKIQDAHEAIRPTDVTLSPVMVKEQLSRDQFRLYQLIYNRFLASQMAGAVYSVKSVKVSCGDATFQTSASKIAFDGFLAVYNLDNDRGETVAGINNLAEGDVLELDGFEEKQHFTQPPARYTEALLVKTLEELGIGRPSTYAPTISTILARRYITKEQKKLYVTAIGDAVNQSMEQAFPVIIDVNFTANMESLLDKIGEGTVDWKVVVRNFYPDLDEAVKKAEAELESIKIEDEVSEEVCDVCGRNMVIKYGPHGKFLACPGFPECRFTKPFYEKIGVTCPKCGGDVVIKTTRKGRRYYGCINAPECDFMSWAMPSNEKCPECGKYMIVKGNKLVCSDQECGYTCNNKAAETADK
(910) DNA topoisomerase 1 [Lactobacillus kefiranofaciens ZW3]
1
MPTKVKSKTKTTKRNTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDNYKPKYISIRGKGDTIKELKSEAKKAKDVYLASDPDREGEAIAWHVAHALNLDEKAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWTIDAEFKKEKESFKSAFYGLNGKKTELANIDAVKDVLAKIDKKKDFTVEKVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRTSPVAQKEASQFLHENYGAEFAAKSQRHFQNQEDAQDAHEAIRPTSVYRTPASLKSVLTTEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVIFRTTGSKMRFAGFTKVYDNQQEKNVDLPDLQEGDRVKMSKSDNKQHFTLPPARYTEASLVHALEENGVGRPSTYAPTIDTIQRRYYVKLEGRSIVPTELGEIVDTLIEQFFPDIANVDYTAHLENELDEVEDGQKEWTHVVDEYYQPFKQELNKADSEIEKIQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKIGVTCPKCGKGEVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKKSKKGLTVLCPNGDYREEPQEGESNK
(915) DNA topoisomerase 1 [Lactococcus garvieae ATCC 49156]
1
MAKASEKQTTKKKKTSSKKTASKKKTKIVKGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIDNDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAIAWHLAHILGLPLEDKNRVVFNEITKDAVKNAFKEPRSIDVDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPQEYWSIDGEFKKGAKKFKAAFWGVDGKKRALNNNDDVMEVMSRLSGPDFDVDKVEKKERRRNSPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGLTLGAQGHQGLITYMRTDSTRISPVAQGVAADFITDRFGAKYSKHSSKVSNKAGAQDAHEAIRPTNVLNTPEAIAKYLDKDQLKLYTLIWNRFVASQMTAAIFDTMKVNLSQNGVIFIANGSQVKFDGYLAIYNDSEKNNMLPDIAAGDVVKKANLKPEQHFTQPPARYSEATLIKVLEENGVGRPSTYAPTLETIQKRYYARLVAKRFEPTELGEIVNKLVVEFFPNIVNTEFTAEMEKDLDKVEEGQRRWVDVVDQFYKPFAVELEKAEVEMEKIVIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAIVKEIGVTCPSCHKGQIIERKTKKNRLFYGCDRYPECEFTSWDKPVGRSCPKCEHYLVEKKVRGGGKQVVCSNETCDYKEEKQK
(916) DNA topoisomerase 1 [Lactococcus garvieae ATCC 49156]
1
MAKASEKQTTKKKKTSSKKTASKKKTKIVKGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIDNDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAIAWHLAHILGLPLEDKNRVVFNEITKDAVKNAFKEPRSIDVDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPQEYWSIDGEFKKGAKKFKAAFWGVDGKKRALNNNDDVMEVMSRLSGPDFDVDKVEKKERRRNSPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGLTLGAQGHQGLITYMRTDSTRISPVAQGVAADFITDRFGAKYSKHSSKVSNKAGAQDAHEAIRPTNVLNTPEAIAKYLDKDQLKLYTLIWNRFVASQMTAAIFDTMKVNLSQNGVIFIANGSQVKFDGYLAIYNDSEKNNMLPDIAAGDVVKKANLKPEQHFTQPPARYSEATLIKVLEENGVGRPSTYAPTLETIQKRYYARLVAKRFEPTELGEIVNKLVVEFFPNIVNTEFTAEMEKDLDKVEEGQRRWVDVVDQFYKPFAVELEKAEVEMEKIVIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAIVKEIGVTCPSCHKGQIIERKTKKNRLFYGCDRYPECEFTSWDKPVGRSCPKCEHYLVEKKVRGGGKQVVCSNETCDYKEEKQK
(917) DNA topoisomerase 1 [Lactococcus garvieae ATCC 49156]
1
MAKASEKQTTKKKKTSSKKTASKKKTKIVKGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIDNDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAIAWHLAHILGLPLEDKNRVVFNEITKDAVKNAFKEPRSIDVDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPQEYWSIDGEFKKGAKKFKAAFWGVDGKKRALNNNDDVMEVMSRLSGPDFDVDKVEKKERRRNSPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGLTLGAQGHQGLITYMRTDSTRISPVAQGVAADFITDRFGAKYSKHSSKVSNKAGAQDAHEAIRPTNVLNTPEAIAKYLDKDQLKLYTLIWNRFVASQMTAAIFDTMKVNLSQNGVIFIANGSQVKFDGYLAIYNDSEKNNMLPDIAAGDVVKKANLKPEQHFTQPPARYSEATLIKVLEENGVGRPSTYAPTLETIQKRYYARLVAKRFEPTELGEIVNKLVVEFFPNIVNTEFTAEMEKDLDKVEEGQRRWVDVVDQFYKPFAVELEKAEVEMEKIVIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAIVKEIGVTCPSCHKGQIIERKTKKNRLFYGCDRYPECEFTSWDKPVGRSCPKCEHYLVEKKVRGGGKQVVCSNETCDYKEEKQK
(932) DNA topoisomerase 1 [Rickettsia typhi str. Wilmington]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDKNFAMEYDISDKASKYVDAIVKYARKAEAVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICDREDEIERFKAEEYWDISLKMQNSNNELFTAKLTHVNDQKLKKFSIINEKEAKDLTRKLKLQKFYVEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGNKYLPINPRIYQSKVKNAQEAHEAIRPTNITYTPDNLKQKLEKDYYKLYELIWQRTIACQMENVIMDLVIANLASENKEYLAKANGSIIAFDGFYKVYRESLDDEDEEDNKMLPPLKAQEHIKTKEVIPNKHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKTSLNNFWSGFNNNIESVNEQKITEIINYLQKALDYHLFGENKESKVCPSCKTGQLSLKLGKFGAFLACSNYPECTFKKSIVSGNDNNEDEGNLSTILNDNKILGTDKDGVEIYLKTGPYGPYIQLGEQCGKVKPKRTPVPTNLKQSEITLEVALKLLSLPLKIGIHKDSGEEIIIGYSKFGPYIKYMCKFISVPKKYDFLNLNLDDAIKLIENNKAKLEKKHRSMV
(934) DNA topoisomerase 1 [Robiginitalea biformata HTCC2501]
1
MAKNLVIVESPAKAKTIEKFLGKDFKVTSSFGHIADLPSRELGVDVDKDFSPKYVVDKEKKALVKKLKELASKAETIWLASDEDREGEAISWHLAETLKLDADKTRRIVFNSITKSAIQKAIENPRKINYDLVNAQQARRILDRLVGYELSPVLWKKIKPGLSAGRVQSVAVRLIVERERAIEEFEPQSSFKVAAEFRTENGATLPAKLNESFDTETEAQEFLAGLANASFAVDSLDTKPAKKSPAAPFTTSTLQQEASRKLYFSVSRTMQVAQRLYEAGLITYMRTDSVSLSGEAIAAAKEEIVGNYGEKYSKVRKFQSKSKGAQEAHEAIRPTDMGLQRPNVERDQARLYELIRMRTLASQMSDAQLERTQVKIRNDRDDRLFSANGEVIKFDGFLKVYLEGKDEEDAEEQDGMLPAMQVDEALTNNYITATQRFTRPPYRYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTVDGTEREYLQLTLEGGGVKRKELSETVGSDKGKLVPTDIGMIVNDFLVSHFANILDYNFTAKVEKDFDDIATGEEDWQDVLRDFYKDFHPNVLDVEENADRASGERVLGTDPETGRQVAVRLGRFGPMVQIGTADEEEKPQFASLLPDQSLATITYDEAMELFKLPRKLGTFEGDEVEANVGRYGPYVRYGKKFVSLDEGESVFDVDMERAAELIRAKKKQDAPIASYEDKPVTKGKGRFGPFIKWDGMFINVPKKYDFDNLSQADIEELIEAKKKKEAEKLVREWPEEDIRIEKGRWGRHTVIKGRKKVDLSKDVDPQAVTLEEAQELLSKKKTRKKS
(938) DNA topoisomerase 1 [Thermanaerovibrio acidaminovorans DSM 6589]
1
MTMAARSKSAPEAKAPKTAKGSKATGKGSRASGTRSPKVGPVETLVVVESPTKAKSLSKMLGPGYAVEASLGHVMDLPKVRLGVDVENGFEPEYIQVRGKGPVIKRLKELARGASRVLLASDPDREGEAIAWHLATLLGVPLDSPCRVRIHEITPSGISAALQEVEGIDMNKVYAQQARRVLDRLVGYRLSPLLWAKVQRGLSAGRVQSVALRLVCEREDEIDSFVPEEYWLVEVQAEAEGGRSYLLKLDKEAGKPVRLKDQADARRVEALVRSSPLQVSSFRSRDGLRRPMPPFKTSTLQQEASRRLGYGPRRTMRIAQSLFEGVEIPGRGPVGLITYMRTDSLRISDEAISAMRGHIASRFGPMYLPERPNHFAQKGRSQDAHEAIRPTDVTLEPDAIREYLSSEQYRLYDLIWRRALASQMADARVRTNTLEARCGELTFKCSGVEVTFQGWGAVWPLGVKDTEVPAASEGEDLRPLQVRLEQKFTQPPGRYTEAGLIKALEEKGIGRPSTYATIVETLSDRGYVVRDDDKKLSPTKLGRVVNAFLVTHFPDVVQVDFTARMEDQLDRVESGEIQWREPIGDFYGPFESRLQEVAASAQRMTVPPELAGEDCPQCGRPLLIRRGRYGEFIGCSGYPECDFTKRKETSTGVPCPKCGQGTVVARKASKGKGKGRTFYGCSRYPECDYVSWSKPKGDGTVSEVRDEV
(939) DNA topoisomerase 1 [Prochlorococcus marinus str. AS9601]
1
MDHTLVIVESPTKAKTIRKFLPSNYEVLASMGHVRDLPKGAAEIPASVKKEKWSRIGVNTTEDFEPLYIVPKDKKKVVKELKDALKGATQLLLATDEDREGESISWHLLQILKPKIPTKRMVFHEITKKAINKALDQTREIDMELVQAQETRRILDRLFGYELSPLLWKKVAPRLSAGRVQSVSVRLLVRRERERRSFKKASYWGIKASLVKDNITFETKLFSLKGQRICNGSDFDEQTGKLKEGNKSLIIGEEQVNDLLNTFSSEDWLVSKIEKKPSTRKPVPPFTTSTLQQEANRKLRLSSRETMRCAQGLYERGFITYMRTDSVHLSEQATRAARECVSSMYGKEYLSNSPRQFNSTARNAQEAHEAIRPAGEVFKTPKETNLTGRDLSLYDLIWKRTVASQMAEARLTMINAEISVGYGLFKSSGKSIDFPGFFRAYVEGSDDPSSSLEQQEIILPNLTTGTCLEVTSKESTFHETKPPARYTEAALVKVLEKEGIGRPSTYASIIGTIVDRGYANISSNTLAPTFTAFAVTALLEEHFPDLVDTTFTAKMESSLDEISSGNLEWLPYLETFYKGKNGLEIKVQKTEGNIDGKAYRQVDFEDLPCVVRIGSNGPWLEGTKIDESGNEIQAKGNLPMDITPGDLDIKQVDQILSGPSDLGTDPKTGEKVFLRFGPYGPYVQLGNNDQDKAKPRRASLPKELKTDDLTLDEALVLLSLPRLLGAHPEGGVVEADRGRFGPYIKWIKNENESENRSLKKEDDVFRVDIKRALEILAMPKMGRGGQEVLKDFGKPKEFKEKIQILNGRYGVYLKCGKTNVSIAKDTDIEKFTIDEAVSLLEEKLKDKKGAILKKTKISNKKTSRKKKS
(940) DNA topoisomerase 1 [Bacillus pseudomycoides DSM 12442]
1
MESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIDREKEIQSFIPEEFWTIKTEFVKGKDTFEASFYGVNGEKVQLTNEAQVKDIIETMKNNAFSVENVTKKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDIGKQGTVGLITYMRTDSTRISETAQEEARSYITEAFGSEYIGTEKKKETKKANAQDAHEAIRPTSVMRKPEELKSFLSRDQHRLYKLIWERFVASQMASAVMDTVTARLINNNVQFRASGSVVKFSGFMKVYVESKDDGAEEKDKMLPPLEIGETVFSKDMDPKQHFTQPPPRYTEARLVRMLEELGIGRPSTYVPTLETIQKRGYVALDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQNLDEVEEGKANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCGHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(942) DNA topoisomerase 1 [Bradyrhizobium sp. ORS 278]
1
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPEENFRMIWEVDPKAAGRLNDIAKSLKGADRLILATDPDREGEAISWHVLEVMKEKRALKDQKIERVVFNAITKQAVSEAMKNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVPREYWSLIATLATPRGDTFEARLVGADGKKIQRLDIGTGAEAEDFKNALNAATYSVATVDAKPARRNPQAPFTTSTLQQEASRKLGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIAPEAITQARKVIGEIYGNKYVPDSPRQYQTKAKNAQEAHEAIRPTDLSRKPAELRKRLDDDQAKLYELIWTRTIASQMESAELERTTVDIVAKAGGRTLELRATGQVIKFDGFLALYQEGRDDEEDEDSRRLPQMSQGEALKRQNLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILDVLKARGYVKLEKKRLHGEDKGRVVIAFLENFFRRYVEYDFTADLEEQLDRISNNEIAWQQVLKDFWTGFIGAVDDIKDLRVAQVLDALDEMLGPHIYPPREDGGDVRQCPTCGTGRLNLKAGKFGAFVGCSNYPECRYTRPLAADSEAAADRMLGQDPDSGLEVAVKAGRFGPYIQLGEQKDYAEGEKPKRAGIPKGTQPSDVDLDLALKLLSLPREIGKHPETGLPITAGLGRFGPFVKHDKTYASLEAGDEVFDIGLNRAVTLIAEKVAKGPSKRFGADPGKALGDHPSLGPVAVKAGRYGAYVTAGGVNATIPGDKEKDTITLAEAIALIDERAAKGGGKAKAPKKAAKPKAAAKPKAGGDDDTPKPAKKAVAKKAAAKPKSDSTSKARAPVAKAAKTSAKPATKATPKKSAGKARG
(943) DNA topoisomerase 1 [Pseudogulbenkiania sp. NH8B]
1
MPSSLLIVESPSKAKTLKKYLGQDFEVLASYGHVRDLVPKSGAVDPDKNFAMKYQLIPRNAKHVDAITQAVAEADHIYLATDPDREGEAISWHLVQILNNKKLLKGKTAQRVVFHEITKNAVLDAIANPRDISQELVDAQQARRALDYLVGFNLSPMLWKKIRRGLSAGRVQSPALRLICERENEIRAFTEQEYWSIHLDSHKGRQKFGAKLFELGGNKLDQFDIPSEAVQADTLARLAEQPATVSNVDKKKKTRNPAAPFTTSTLQQEAVRKLGMTTDRTMRTAQQLYEGVDIGQGTVGLITYMRTDAVVLSNEALTEIRGYIESQFEPAFLPKAPVTFKNKSKNAQEAHEAIRPTSIERTPAAMKPFLTTDQFKLYEMIWKRTLACQMAPAKFDTTSVDITVGEGVFRATGQVQTFAGFLAVYEEDVDDAEDEDNAKLPALEVGDVLPVDKLYGEQHFTQPPPRFSEASLVKALEEFGIGRPSTYASIISTLKDREYVVLDKKRFLPTDTGEIVNKFLTEHFGQYVDYNFTAKLEDQLDEIANGRREWVPVMETFWKGLAKQLSEKESLSRAEVTTESLDEACPKCSKPLQIKFGKRGRFIACTGYPECDYTRDIGETAESAAAAAEEPTVIEGRTCPECGGALHIKKGRYGKFIGCANYPKCKHIEPLEKPRDTGVTCPECKTGSLIERKSRYGKLFYSCNTYPKCKYATWNPPVAEPCPKCHWPILTIKTTKRRGTEKVCPQKECGYSEVIAPPEAKEA
(950) DNA topoisomerase 1 [Rhodobacter capsulatus SB 1003]
1
MAVVVVESPAKAKTINKYLGSDYTVLASFGHVRDLPPKDGSVDPDADFEMKWEVAADSKKHIKAITDALANDDELILATDPDREGEAISWHLQQALASKLKKKKVSRVTFNAITKSAITEAMKAPREVDQALVDAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVCLRLIVEREMEIEAFRAREYWTVTAELTTPRGQTFTARLTVLGGKKLDKFDLTTATDAELAVQAVTSRDLTVKSVEAKPATRNPYPPFMTSTLQQEASRKFGMGAKACMSAAQRLYEAGHITYMRTDGIDMAPEAVMAARDEIKRRFGDKYVPSSPRMYKNKAKNAQEAHECIRPTDMSQSPDKLKLADDQWKLYDLIWKRTLASQMSAAVMERTTVDVGSKDNEVELRATGQVVTFDGFLKIYDQGRDDDEGEDGARLPQIMQGEPAQKGAITPEQHFTQPPPRYTEATLVKRMEELGIGRPSTYASILTTIVDRGYVRKDKNRLIPEDTGRLVTAFLSNYFRRYVEYDFTADLETELDDISAGDRPYRDVLARFWRDFSAALAETADLRIGEVLSKIDEVLGPHLYPARADGSDPRSCPVCSAGRLHLKTARSGGAFIGCGNYPDCRYTRPLSAPADGEAGVLDGKVLGEDEGAQITLRVGRFGPYVQKGEASEEIPKPPRASLPKGWSPESIDLERALQLLNLPRPIGNHPEDGALVEAGIGRFGPYVKHNSTYANLPDVEEVFTIGMNRAVEVLAQKLARGGARGSAAAAQPLKDLGEHPEGGVVQVMPGRYGPYVKWGKVNATLPKGTEPEAMTLEEALPLLEAKASKGGKKAAPKKAAKPAAEKKPAAKKAATKTATKTAAKKPAAKKAAPKKAAPEADVVED
(963) DNA topoisomerase 1 [Bacillus mycoides DSM 2048]
1
MGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKYPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREKEIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNEAQVNEIIEKMKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARDYITEAFGAEYIGTEKRKETKKSKAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTAKLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDIEPKQHYTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVALDNKRFVPTELGGIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCSHPMVFKMGKYGKFMACSNFPECRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(965) DNA topoisomerase 1 [Thermincola potens JR]
1
MSKVLVIVESPAKAKTIGKFLGSRYRVKASMGHIRDLPKSQVGVDVEHDFAPKYITIRGKGEILKDLKQAAQKSSKVLLAPDPDREGEAIAWHLMHYLDINEKDKCRIEFNEITKDAIVNAIKEPRTIDRHRVDAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEIKAFVPEEYWDITGVFTGTDKKWTIEAKLLQKGKEKIHIGSEAEAQAILDDLKDASFLLTKLRKKEKKRNPVAPFITSSLQQEAYRKLNFPARKTMQVAQQLYEGLDLGPEGTVGLVTYIRTDSTRVAETAQAEAREYIKGKFGTGYVPEKARQFTTKGKIQNAHEAIRPTSVFREPDQIKNFLSRDQYKLYKLIWERFVSSQMSPAVLDTTSIDIEAGDYTFRAHGSIIKFPGYMKIYTEGKDEDDNEEEKTLPENLEEGLRLIAKSLVPKQHFTQPPPRYTDATLIKALEEHGIGRPSTYAPIVETIQKRGYVVKEQKQFHPTELGMVVVELLKEHFTDIIDIQFTAAMEEKLDLIEEGDMDWVQVLKDFYLPFKDTLERAEKVIGQVELEDEVTEEICELCGRNMVVKMGRYGKFLACPGFPACRNTKPLLEETGVKCPHCDGRLVLRRSKKGRKFYGCSNYPDCDFVTWDLPTEKKCPKCESMLVQKKFKNKGAVYQCISENCNYKEKAETITI
(966) DNA topoisomerase 1 [Weeksella virosa DSM 16922]
1
MSKNLVIVESPAKAKTIQGFLGNDFIVESSFGHVVDLPKKGMGIEIDNDFQPNYEVTPDKKEVVKKLKSLSDKAKVVWLASDEDREGEAIAWHLYNELGLDKKETKRIVFNEITKKAIQHAIENPRSIDINLVNAQQARRVLDRLVGFEMSPVLWRKIKPGLSAGRVQSVSVRLIVEREKEIQDFQPVATFCFVATFRTEENKTLPASLTQEFDSFDQAKEFIESCVGASYSVKDLQKKPAKRSPSAPFTTSTLQQEASRKLGFSVSRTMRVAQQLYESGYITYMRTDSVNLSEDALSAIKKTIQTLFGEKYAYKRKYTNKNTSAQEAHEAIRPTNFENQTIQADASMKKLYDLIWKRTVASQMANADLERTIIDIENSKNQQIFQAKGEIIVFDGFLKVYQESLDDEDIEDDKSILPKVSKGEKLDVSIIQGQEKFTRAPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEVGEIEGKNRNYRVIQLENDTITTEVKTEVYGADRRKLIPTDIGIVVNDFLVDYFSKVLDYDFTAHVEESFDKIAEGKQQWTKMIEQFYQKFHTQVEDVKENADRATGERELGIDPVSGKKVYARIGRFGPMIQIGEAEDEEKPKFASLLKTQSIHQVTLEEALKLFELPKKLGNYKGYDLEVNIGRFGPYVKFDTKYVSIPKEEDPMDITFERAAELVEEKLQADAPIAQYEGQDVTKGVGRFGPFIKWQEWFINVPKKYDFDHLSQADIEELIEAKKQKESERVVREWVEEEIRIEKARWGRFNLIHGKNKVELSKDTPVVELTLDEVKKLLGSDKTKTKTAAKKTKTTTQKSIKKK
(967) DNA topoisomerase 1 [Anaerolinea thermophila UNI-1]
1
MVIEAYCVKCKTKREIQDPVAEFTATGSPVTRGVCPVCGTKIFRLGKTPEHEKLTPPESVRKEKTKTRSGKLVIVESPAKAKTVGRFLGKGFTVKASVGHVRDLLRSELSVDIEHDFQPKYRVPNEKRAVVKELKALAQEAEEIYLATDPDREGEAIAWHLMQAAEIDPRLSKRVVFHEITKPAIDEAFSHPREINMALVDAQQARRVLDRLVGYNLSPLLWEKVRSRLSAGRVQSVALRLIVEREREIQAFIPVEYWSIEAELQPEGVSSTFIAKLSKIDEQDPELPNQEVVSRYLADLEQALFIISKIRRSERRRKPAAPFITSTLQQEASRRLGFTARRTMAIAQQLYEGLDVGEGGTTGLITYMRTDSTNISEVALREVREFIKETYGGSYLPESPLQYKTRAVSAQEAHEAIRPTSVARTPEKVKPYLSPEQYKLYQLVWQRFVACQMESAVYDTLSVEVDAKGEEHQYLFRASGSTLKFPGFLVVYEESRDEDQVSEDEGTETRIPAHIQEGQKQELVRLIPEQHFTQPPPRYTEATLVQVLEENGIGRPSTYAPILSTIQERGYVVRDGKRLVPTETGILVNDLIVAHFPDIVDTGFTAKMEEDLDRIAAGNEKWVNVIRQFYQSFSPQVERARMLMPESKSEPEKVGRQCPQCGHDLIVRWGRFGKFISCSNFPNCRYTEPWLEKIGVRCPKDGGEIVERRTRKGRVFYGCENYPNCDFTSWKRPIPASCPQCSGMLVIANKREVQCLSCQEMFLMEQFVENVEVNQP
(974) DNA topoisomerase 1 [Helicobacter mustelae 12198]
1
MKKLIIVESPAKAKTIQNFLGEEYQVIASKGHIRDLPKMRFGIHIKQESFEARYVIDEDHQEIAKNIKELAKQSSQVYIATDEDREGEAIGYHITQAIAKDPQSFPRIVFHEITKTAIQDALANPRNIDMNKVNAQQARRFLDRIVGFKLSSLVSSKIAKGLSAGRVQSAALKIIIDKEREIQKFIPLDYYSIEGNFLGLSAQLIAYQGKKLKEQEITEEARAKQMQENLQKNLYTIGDLQKKSKKSPTPPPFMTSTLQQSASNLLGYSPTRTMSIAQKLYEGVQTHQGYMGVITYMRTDSLNIAKIAQDQAREHILKAFGQAYLPKKPKIYATKNKSAQEAHEAIRPTNLDFTPEIAKNYLKNEELKLYTLIYHRFLASQMEDAILESQSITFIGEEGEFKANGRRLLFDGFYKVLGNEDKDKLLPELEVGAKIKPQSLEVNKHTTQPPARYSEASLIKILESLGIGRPSTYAPTIALLNSRYYIKIENKQIHPQESAFKVIEMLENHFDKIVDATFSASLETKLDEIAENKQNWQKFLWDFYEPFMEQINAGKTDIASQKMKIPTGEYCPQCGSELLLRESRYGEFTACGAYPKCKYIKPQEEEGEKDPESCEKCGKPMVTKMGRNGSFLACSAYPECKNTKSLLAKPSQQKVLEGVACPECGGEILLRNSRRGAFYGCSNYPKCNFLSKFPPTNHKCPECNYLMNDRTYRGRAIFECIKCKHRVDQ
(975) DNA topoisomerase 1 [Clostridium beijerinckii NCIMB 8052]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIENNYTPKYITIRGKGELIDKLRKAAKKAEKVYLATDPDREGEAISWHLANILKISEDETCRIVFNEVTKTAVKASIKQARKIDLDLVDAQQARRILDRLVGYEISPILWKNVKWGLSAGRVQSAALKLICDREKEINEFIPKEYWSIDCTLKKEKKKFPVRLSTYKGKKIEIGNEETSNGIIKELNKGNFVVKSIKKGKKNRNPLPPFTTSTLQQDANRKLNFMTKRTMSIAQVLYEGVEVKNYGTVGLITYMRTDSVRISEEAQESAKEFIEGSYGKEYLPGAPRVYKGKKNIQDAHEAIRPTYVEITPEIAKENLTPEQYKLYSLIWNRFVASQMASCELNTHSIDIENGDYKFKASGSVISFDGFMKIYEYSNEEDENSVMLPELKENEELKVESLNGTQHFTQPQPRYTEASFVKLLEEKGIGRPSTYVPTISTLLGRNYVIREKKNLIPTELGEIVNNIVSEYFRQIVDVDFTADMERKLDDVEEGSENWTQIVEEFFSPLKVAIEKAEKEISKVVIEDKVSDVKCEKCGRMMVIKRGRFGEFLACPGYPECKNAKPIVEELDVPCPECGKPIVAKKSKKGKKFFGCLGYPECKFVSWYEPVKEKCPNCNSYMVAKYSKTKGNYIQCSNSECNYKEEVKKDNSKEE
(977) DNA topoisomerase 1 [Methylococcus capsulatus str. Bath]
1
MAQHLVIVESPAKARTIEKYLGKSFQVYASYGHVRDLIPKEGAVDPDHDFSMKYAIIEKNKKHVQAISKAMEKADALYLATDPDREGEAISWHLYELLKEQQVLDSKPVHRVVFHEITKRAITEAVENPKTLSTDLIHAQQARRALDYLVGFKLSPLLWKKIRRGLSAGRVQSPALRMIVERELEIERFEVQEYWTIEAAIQTEDQALSARLTHLAGEKLEQFSIVNEAQAQATRQSLLDQARGKLQVVRVEERERKRNPAAPFTTSTLQQEAARKLGFTTRRTMTVAQQLYEGIDLGGEAVGLITYMRTDSVNLAQEAVQELRALIESRYGKDNLPAQPRLYKTKSKNAQEAHEAIRPTSAFRTPESVKAHLTPDQFKLYSLIWKRSVACQMVHATLNTVTVDFACGSADNLFRATGSTVIHPGFMSVYREGRDDMPEESDEIYLPKLVEGQEVDLKDVTPSQHFTEPPPRYTEASLVKALEEYGIGRPSTYATIISTLQQRHYVELENKRFRPTDLGRVVNKFLTEHFNRYVDYNFTANLEDDLDAVSRGEKDWIPLMREFWGPFHALIGEKDESLKRADVTHEAIDEKCPECGSPLSIRLGRNGRFVGCTNYPQCKYTRNLAGKESEQTEPEVVEGRQCPKCHSPLVIKTGRYGRFIGCSGYPACRHIEPLEKPTDTGVPCPECGQGTLTKRKSRFGKLFYSCSTYPKCSYAVWNPPIAEACPACQWPVLTLKTTKRRGTEKVCPRKECGYAAPYEGEPLTDFAA
(978) DNA topoisomerase 1 [Zunongwangia profunda SM-A87]
1
MAKNLVIVESPAKAKTIEKFLGKDYKVASSFGHIADLPTKELGVDTEGDFSPKYIVSKDKKDVVRKLKGLAKDAETVWLASDEDREGEAIAWHLAEELKLKDDRTKRIVFHEITKSAILNAIENPRGINYNLVNAQQARRVLDRLVGYELSPVLWRKVKGGLSAGRVQSVSVRLIVEREREIEDFTPEASYRIDAEFANAEGKTFRAKLPKNFDTKEEAEAFLKDNLGADFKVVDLTKKPAKKSPAPPFTTSTLQQEASRKLYFSVSKTMTLAQRLYEAGHITYMRTDSVNLSDDARKGAHREILKAYGEEYAKSRQFKGKTKGAQEAHEAIRPTNFASHSVRADRDEQRLYELIWKRAIASQMSEAQLERTNVKIEANKHDKVFTANGEVLKFEGFLKVYLEGSDDEDSEEQNGMLPDMKVNEQLQNIFINATERFTRPPYRYTEASLVKKLEELGIGRPSTYAPTISTIQNRNYIEKGSVDGTEREYTQFTLENGKVSEKKLTETVGSDKGKLVPTAVGKVVNDFLVNHFSNILDYNFTAKVEQSFDDIAEGNEEWTKMMKDFYTDFHPHVQDVAKNADREVGERILGEDPETGKPVSVRLGKFGPMVQIGSVEDDEKPKFASLSPDQTLDTITYEEAMDLFQLPKELGEYKGEKVEVNNGRYGPYVRFGKKYVSLEKGEDPMSVDFDRAMELIKEKEKADAPIYEYEDKPVQKGVGRFGPYLKWNGIFINVNKKYDFDNLSDEDIVELIEDKKRKEREKIIHHWEDEGIRVEKARWGRSNVIKGKTKVELPKTVDATKITLEEAKDIIAKKAPKKKAAKKTTKKKTAAKKTTKKTTKKTSKK
(979) DNA topoisomerase 1 [Clostridium cf. saccharolyticum K10]
1
MAKNLVIVESPAKVKTIKKFLGSNYEVDASNGHVRDMPKSQMGIDIEHGYEPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLSKALKLEDCKDKKVYRITFNEITKNAVKAALKTPRAIDMNLVDAQQARRVLDRMIGYRISPLLWAKVKRGLSAGRVQSVALRMICDREEEISSFIPEEYWNLEAKLKAKGSKKKLTAKFYGTREGRMAIHKKEELEAVTAALEGAQYTVDEVKTGERVKKAPIPFTTSTLQQEASKTLNFSTQKTMRLAQQLYEGVDIEGKGTIGLITYLRTDSTRVAEEADKTAREFIEEKYGKQYVSTEEAVKKGGAKIQDAHEAIRPTDISLTPAVVKESLARDLFRLYQLIWKRFAASRMQAAVYETTSVRVAAGYAGGEYLFTLSASKLKFDGFMSVYVQEDEKEESTVLSEKLEKGDVLACEALESSQHFTQPPAHYTEASLVKALEEQGIGRPSTYAPTITTILARRYVVKENKNLYVTELGEVVNRMMKKAFPSIVDTAFTANMEYLLDRIGDGTVQWKTVIENFYPDLEEAVKEAEKKLEAVKIADEVSDVPCDLCGRMMVIKYGPHGKFLACPGFPECRNTKPYLEKIGVACPKCGKEIVIRKTKKGRKYYGCENNPECDFMSWQKPSAERCPECGGLMVEKGNKLLCTNKECGYVKTKENRQQQE
(980) DNA topoisomerase 1 [Treponema primitia ZAS-2]
1
MAVKTEKIETTKKAEKKVKGKKAGKERKILVIVESPAKAKTIEKYLGPSYTVKASMGHLIDLPKSRIAIDVENNFEPEYITVRGRAKLLKELQGDAKKADTVLLASDNDREGEAIAWHLRNAIIAKTDKVPIRRISFNEITPVAIKAAVANPTDIDESKVNAQKARRVLDRLVGYNLSPLLWKKVKNGLSAGRVQSVALRLICEREKEVETFIPEEYWTLEADFKTSKTVFTAQLVSWKGAKPDLKNEGDVKSIVDQITGLDCSVLDIRETDKTVKPKPPFTTSQLQQTAANRLGFTSKKTMQIAQQLYEGVNIGSSRIGLITYMRTDSVRISQTALDEVRTWIGEKYPKDLPEKVVEYVMGKKAQDAHEAIRPTYVSYLPDDMKDHLTRDQLRLYTIIWERFVSSQMNPAKTKTVSTDIKAGEGIFRIAGTKIVEKGFYRVLKLLNTKEEKGSSYPVLKIGDIVTADKFSPEQHFTQGPPRYTDATIIKTLEDKGIGRPSTYAPIISVLIDRYYVTRPNKQLVPTLVGRMICDMLVENFSTVVDVAFTADMENKLDEVEESHILWPDMIRGFYQPFKDQVDLVDKSLESFKGSLDEATDYVCEKCGKPMIKKLGRFGFFLACSGFPECRNTKSIPLAKCPKCGGDIVARKTRGRGKEFYGCTNYPDCDFISHFKPLNQDCPKCGHFLVEKYDKKNGNHKACINPECDYLHSDDDEETADAE
(981) DNA topoisomerase 1 [Legionella longbeachae NSW150]
1
MSKHLVVVESPAKAKTIQKYLGNDYEVIASYGHVRDLPARKGSVNPDKQFAMTYVPIEKNARHIETIAKILKKSDSLLLATDPDREGEAISWHIYELMKEKNLTKDKTVHRIFFNEITKSAIQDAINHPRTISMDLVNAQQARRALDYLVGFNLSPLLWKKVRRGLSAGRVQSPALRLIVEREEEIESFVAQEYWKILAQCFHANSPFEARLTHYKNEKIQQFTIVNQEQAQQIKEFLIDQAKGSLFVTNIEKKQRKRKPSPPFITSTLQQEAARKLGFTARKTMMVAQQLYEGIDIGTGTVGLISYMRTDSVNLSVEAIEEIRQFITERFGAANCPTSPRAYKTKSKNAQEAHEAIRPTSIKRVPEMVQSSLTTDQYKLYNLIWKRTIACQMADAVLDTVAVDLTCGEGTIFRANGSTVTFPGFLSVYEEGRDDAKDDENDGSLLPVLVVGEKVNVQDILANQHFTEPPPRYSEATLVKALEEYDIGRPSTYATIIHTLQQREYVVVDKKRFFPTDVGRIVNRFLTGYFTRYVDYKFTAELEDTLDAVSRGEKEWIPVLDEFWKPFVQQIKTTDEQVQRKDVTSEVLDEKCPKCEKPLSIRLGKRGRFIGCTGYPECDYTQDIAGQENEKKEPEVIEGRVCPECSSPLHIKVGRYGRFIGCSNYPQCKHMEPIEKPADTGVDCPKCHQAKILQRKSRKGKIFYSCGNYPKCDYALWNEPINQPCPKCNWPILTVKESKKFGRQILCPQEGCGHSTKEE
(986) DNA topoisomerase 1 [Thermovirga lienii DSM 17291]
1
MAVKKAKNSKASKKKTLVIVESPSKAKTLTKLLGRGYEVKASVGHVRDLPKSRLAVDIENNFQPDYIVVRGKGQVVKELKKKASESSRVILASDPDREGEAIAWHLAEILGISAESPCRMRMYEITPKGVKEALGGLGPIDMNKVYAQQARRIMDRLVGYSISPILWRKIKWGLSAGRVQSAALKIVCDRERAIEDFVPQEYWNISVEAQKENGALYNLRVEKRGGKTLLKDGKTLLIDSEKVADEIIEVIVSNPLVVKDFTSKEGERKPPAPFKTSTLQQEAARRLKFSPRKTMSIAQELYEGVEIPGRGVMGLITYMRTDSLRISPIAIEEVRSLISQTFGQSYLPKKPNSFESKVRSQDAHEAIRPTDVTLTPEQAKQYLSRDQYRLYELIWKRFVASQMSPSIVARVTLEAEAKDIGLKQSGVRVLFDGWSKVWPSDLQEEIVPEAVPGEELSVTNINKEQKFTNPPSRYTESGLIKVLEDKGIGRPSTYATILQTLSDRRYVGKDEEKKLKPTELGKLVNGFLEEYFPEIVDVGFTAKMEEELDEVESAERKWDQVVGEFWAAFEPTLRSAEENAEKLAAPQGEPIGENCPLCGAPLVKRFSRYGEFIGCSAFSDPEKKCTYSRPIVDKIGVTCPKCGKGDVVRRRGKRGRTFYGCSRYPECDYASWYEPTEERCPQCGGVVVLKGAKRNKVCSVCDWKEGKKDDGPNEE
(988) DNA topoisomerase 1 [Leadbetterella byssophila DSM 17132]
1
MSKNLVIVESPAKAKTIEGYLGKDFIVKSSFGHIRDLPDKGMGIDIEKDFEPTYQISPDKVKVVNELKKEAKDKEVWLATDDDREGEAISWHLKEALGLKPDTKRIVFREITKNAINKAIETPRTIDLDLVNAQQARRILDRLVGFQLSPVLWRKIKAGERKNLSAGRVQSVTVRIVVEREREIEQFKSTSTYKIVADFHVSNGKVLSAELPKNLETREQAEQFLNDCVQAIFSISSLEVKPTTKSPAPPFTTSTLQQEASRKLSFSVQQTMTLAQRLYESGKITYMRTDSTNLSAEAVAAAKDQIAKAYGEEFSKSRVFKTKDKSAQEAHEAIRPTDFSVMSAGEDRNEKRLYDLIWKRAIASQMAEAKIERTIAKIGISTRPEELTASGEVIKFEGFLKVYMEGSDEEDEESKGMLPPLNVGQTLDMLQMKATERYSRPPARYTEASLVKKLEELGIGRPSTYAPTISTVIKREYVVKEDRPGQTRDITELVLKEGQIQSAVKQETFGSEKAKLFPTNLGMIVNDYLVENFENILDYKFTADMEADFDEIAEGKVSWQKMIKDFYKDFQVKVEQAAEGASASTQSHELGVDPDSGKKIFAKVGRFGPYLQIGEATDEEKPTFVSLKKGTLISSLTYEEALDILRGPKLPLELGLHEGHPIVVNEGRYGPYVLYNGKFYNLDKGEDPLTVTKERAIALIAAKQSGAEGSLPREMSEYDGQAVTIGKGRFGPYIKWGSKYFNIPKTEDPLTMDDAKVAELIQAGQKEAANKVIKEFPENDKVKVLNGRYGPYIQIGKRNVKIPKGVEPENLTLEECLKLGSA
(991) DNA topoisomerase 1 [Treponema succinifaciens DSM 2489]
1
MAEKTAKKTSKKEAKKNTLIIVESPAKAKTIEHYLGTGYTVKASMGHLIDLPKSRIAIDVNNNFQPEYITVRGRAKLLKELQKDAKNSSGVLLASDNDREGEAIAWHLNNALKEKTAAPIHRIVFNEITPVAIKESVKNPREIDEAKVNAQKARRVLDRLVGYNLSPLLWKKVKNGLSAGRVQSVALRLICEREKEVEDFIPEEYWSLDADFAKGKNKFTAQLVQYKGTKPELKNENAVNDIIKEIQNSECKVLDIKETEKTVRPKPPFTTSKLQQAAANRLSFTSRKTMQIAQRLYEGVQIGNTRVGLITYMRTDSVRISQTAINDVREWIGKNFPEDLPAEKIEYAVGKSAQDAHEAIRPTYVKYTPDSVKEYLTREELRLYSIIWERFVSSQMNNAKSKTTSVDIQAGDALFRVSASKLSHKGFYNVIKTLSSKEDVTGSLPSLKIGEILSSGKFYPEQHFTQGPARYTDASMVKTLEEKGIGRPSTYAPIISVLLDRYYVTRNNKQLVPTMLGKIICKILVESFPDVINEQFTSEVENNLDKVEQNELVWNNMIADFFGPFKNRVEEVMENQESLKGTLDEPTDEICEKCGKPMVKKLGRFGYFLACSGFPECHNTKSVPLAKCPRKGCDGHIVARKTKGRGKEFYGCTNYPECTFISHFKPIDVYCPKCGWFLVEKYDKKNGSYKSCINPDCDYLHSADEAVAAEAAGEFAKANKADKVSKESQNA
(994) DNA topoisomerase 1 [Sinorhizobium fredii HH103]
1
MTMNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLKKKKVIGDKPVKRVVFNAITKKAVLDAMADPRDIDISLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNIVALLKTPRGDEFEARLVSADGKRLQPKSIGNGEDANRLKALLDGASYVVESVEAKPVKRNPGPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDVGGETVGLITYMRTDGVQMAPEAIDAARRAIGSQFGPRYLPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDQVRRVLDGDMLKLYDLIWKRGIASQMASAEIERTTAEIAADNGGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDEDGRLPEINARENLAKQKINATQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATISTLVDRDYVEIDKRKLMPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLREFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRTCQVCGTGKLSLKLGKYGAFVGCSNYPDCNYTRQLSSDSNGDAEAAVSNEPQSLGKDPHTGEEITLRSGRFGPYVQRGDGKDAKRASLPKGWTPATIDHEKAIALLSLPRDIGKHPETGKMISTGIGRYGPFVLHDGTYANLESVEDVFSIGLNRAVSALADKQSKGAGGARGRTAAAALKELGEHPDGGAMTVRDGRFGPYVNWGKVNATLPKGKDPQSVTVEEALALIAERAAKGGVSKGKSAKGRSAATKSTAAKAEKPKAAAKAKSKTAAKAKKG
(995) DNA topoisomerase 1 [Lactobacillus plantarum WCFS1]
1
MAASTTKAKPAAKRKTATKTATKRKSKTPAKKLVIVESPSKAKTIEKYLGRSYKVVASLGHIRDLPKSKMGVDVDNDYEPHYISIRGKGDVIKGLRKEAKKAKAVYLASDPDREGEAIAWHLSYLLGLDPKDKNRVVFNEITKDTVKNAFKEPRSIDMDLVDAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSIALDLIIQRENEIKAFKPQEYWTIDSEFQKGRSKFMASFYGTHGKKQPLDDNDAVQKILGQLDRNGDFNVVKVVKKERKRFPAPPFTTSTMQQDANRKLNFRTRKTMMAAQQLYEGINVGGKEGSVGLITYMRTDSTRISSIAKHEASQFLHKEYGAEYAATKPVKGKLPEGAQDAHEAIRPSSVFRTPASIKDYLTKDQFRLYQLIWSRFVASQMTPEVLDTMAVTIDQNDVQFRANGSKTKFAGFTKIYDKTEKNNVLPDLSEGDVVKLSKTDPQQHFTQPPARYSEANLIKALEENGVGRPSTYAPTLDTIQRRYYVKLEARRFVPTELGEIVNDIIQEYFPDVVNVGFTASLEEQLDATEEGKENWVKVVDSFYKPFSKEVATAEESMEKIQIKDELAGFNCDICGAPMVVKMGRYGKFFACSRFPDCRNTKPIVKEIGVVCPQCKKGQVIERKSKKNRIFYGCSRFPDCDFVSWDKPVGRDCPKDGHYLVEKKVKGGKQVLCPNGDYTENVQK
(996) DNA topoisomerase 1 [Myxococcus xanthus DK 1622]
1
MGIERGTGMADAETDILTAEQQACLALWAVPGLGPRTLVALRAFADGSLAPLAATPVRDWVSQAPVSSQVRRKLASVERLAPVAWRVWEACRASGMKVAFQGQAAYPERLAEVEDAPPVLFYRGVPGLPRRRLAMVGSRHPDQGFLPFARRFARQVAASGVGVVSGAASGVDRACHWGALDEGGETWAFLGSALDALDTAQARLLPHFLDRGGVFFSELPPGVRASTTTFPRRNRLISGASDAVLVLRAGKDSGSLYTAEAGRAQGRPVFAMPGDVRQEEAAGCNALLRNGEAAVCLGPDDVWRVLKVDPLAAVPPGTMGSWEDLSAEAKGGLRDVGPGSPELRRGAGRQHLLTGGARQRAGGVGIDGAGHPAPRKAVRENLGRRVMATRTKKKVEETEAAEEKAPAKKAAAKKAAKKKPAAKKKTAAKKTAARRRTKKGDEDELPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREGEAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQISPLLWKKVRRGLSAGRVQSVAVRLIVEREDEIKAFVPEEYWTLDALLEGPAGPPPFKAKLSKLDGKKVELKERVFTESLVAELQTASFSVAKVDRRERRRNAPAPFITSKLQQEAANRLSFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFLPDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKPFFEAMGEEDMYRLYELIWKRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEGADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVMVEEETTDEVCEKCTKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRDGPYVACPNKECDYRREITEQPGGPGGSPEASSAA
(997) DNA topoisomerase 1 [Sulfuricurvum kujiense DSM 16994]
1
MKLIIVESPAKAKTIKNFLSKDYEVIASKGHIRDLPKNRFGIKIDDEKIIAEYRISEDSTATVKQIQELAKKSDTIYIATDEDREGEAIGWHIAHAIDKDPSSLPRIVFHEITKNAIIHALETPRTIDMDRVNAQQARRLLDRIVGYKLSPLLANKIQKGLSAGRVQSSTLKIVVDREREIRAFIPEEYWTIDTLFKKDIEAALVNFENEKIDKLTIKTGDEAARIVETLKGESFKVGEIETKERKSSTPPPFMTSTLQQTASSQLGFSPKKTMMVAQALYEGVKTPEGTSGVITYMRTDSLNLATEAVEAAREVILTRYGKEYLPKEAKVYTKKSKGAQEAHEAIRPTMLGFTPEVAATYLKPDEIKLYRLIYNRFLACQMNDARFEQQSITFESAKAQFRATGRKLLFDGFYRVTGSDDKDKLLPSLTTGDSIEIQTVTPEQHFTEPPARYSEASLIKKLESEGIGRPSTYAPTISTLQARNYIEIEKRAIMPTEIAFTVTEMLENHFNEIVDASFTATMEETLDEISESGKSWHKILLDFYYPFIEKIDAGKSNIVSLKMAKPLGRNCPQCGSELLLRSGRFGEFIACSGFPKCKYTEQTEENQKENPATPDEVSEEVCDKCGSAMVVKNGRNGKFLACSGYPKCKNTKTLNQETKFSQVPCPECGGKLLWRQSRRGAFWGCEHYPKCKFISKFEPSDKKCEVPGCGGALAPRTYRNKEVYECVKCKDRTPREEAGE
(998) DNA topoisomerase 1 [Bacillus selenitireducens MLS10]
1
MSDYLVIVESPAKAKTIGKYLGKKYNVKASMGHVIDLPKSQMGVDVENNYEPKYITIRGKGPILKDLKQAAKKAKRIYLAADPDREGEAIAWHLADSLKIEEGSKCRVVFNEITKDAIKESFKHPREINTNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIDRENEINAFVPEEYWSITAHLSKDGKQFEAKFQQLDGEKKPLSSKEDVDDILNRLEGGSFEVTGIKRRERKRNPVAPFITSSLQQEAARKLNFRAKKTMMLAQQLYEGVDLGKSGTVGLITYMRTDSTRLSDTAKGEAKEYIGIHYGEEYHQEPKAAKKNEKAQDAHEAVRPTSVMRDPKAMKPHLSRDQYRLYKLIWERMVASQMAPAVMDTMSVDLDVNGAMFRATGSKLKFAGFMKVYIEGNDEGKEEKDKLLPDLNQGDKPASEKVEPAQHFTQPPPRYTEARLVRTMEELGIGRPSTYAPTLDTIQRRGYVSLEEKRFVPTELGTIVLEMIEEFFPEILNVEFTADMETRLDSVEEGSEEWIRIIDEFYQGFEKRLKYAEEEMKEVEIKDEPAGEDCEKCGHEMVYKMGRYGKFMACSNFPNCRNTKAIVKEIGVGCPKCEKGQIVERKSKKRRIFYGCDQYPECDFISWDKPIARTCPKCSEMLVEKKSKKTVQVVCVSCDYKEDSV
(1003) DNA topoisomerase 1 [Listeria welshimeri serovar 6b str. SLCC5334]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLELDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVEGKKKKLSTADDVKEVMSAIKGKTFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEAGNFIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSAMRSPQEVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVKTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFVPTELGEIVNEMIEEYFPEILDVKFTANMESELDEVEHGEVEWVKVIDEFYKQFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVYKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERACPKCNERALVEKKLKKGVQVQCTNCDYKESTQQ
(1004) DNA topoisomerase 1 [Azorhizobium caulinodans ORS 571]
1
MQVVIVESPAKAKTINKYLGPGYEVIASYGHIRDLPSKDGSVDPEADFRMLWEVDPKAQKRLNDIAKAVKVADGLILATDPDREGEAISWHVLEVLREKKALKGQKVERVVFNAITKQAVLEAMKAPRAVDVALVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIELFVAKEYWSIAATLATPRGDTFEARLSGADGKKITRLSVGTAEEAAAFRAALDTAAFSVRNVEAKPVRRHPQPPFTTSTLQQEASRKLGLAPARTMQIAQRLYEGVDIGGETAGLITYMRTDGVDMAPEAVTATRNAISAQYGARYLPGTPRKYTTKAKNAQEAHEAIRPTDPSRHPREMARHLDAEQARLYELIWTRTIASQMESAELERTTADIIAKAAGRELELTATGTVVKFDGFLTLYREGKDDEDDDEESRRLPAMSAGEALDKREIKTDQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLAVLRDREYVKLEKKRLVPEDKGRLVTAFLQSFFKKYVEYDFTADLEEKLDEISAAEIDWKQVLRDFWNDFSLAVDATKELRVSQVIDALDEILTAHLFPAKEDGSDPRLCPTCGSGRLSLKMGKFGAFIGCSNYPECRYTRPLSGGEGEAGGDGVRKLGTDPETGLEVTLRDGRFGAYLQLGEAVDGEKPKRSSLPKGLAPADVDLETALALLALPRRVGTHPEDGEPILAGIGRFGPYIQHGKVYANLEAADDVLTVGLNRAVVLLAEKQSRGRGGRGAAPAGRTLGDHPTEGGAITVRAGRFGPYVNHGKINATLPKSQDPDSLTLEQALALIEAKAAASPSARKPARKSASADGAAKKAPAKKTATKTAAKKTTTKAAGTKKTAKAKADAAAEE
(1013) DNA topoisomerase 1 [Streptococcus sanguinis SK36]
1
MSKLVTKTKKKSTTKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSTMSIDFENNYEPQYINIRGKGPLINDLKKEAKKAKQVFLASDPDREGEAISWHLAHILNLDEKEKNRVVFNEITKDAVKNAFKDPRQIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEINAFKPEEYWTIDGTFKKGTRQFQASFYGMNGKKMKLTNNEYVKEVLSHLKGDDFTVDSVEKKERRRNAPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDKFGAKYSKHGSKAKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMNVKLGQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMEKGDTVKRVNTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVKLVSKRFEPTELGEIVNSLIVEFFPGIVNVKFTAEMEAKLDDVEVGKEQWQKVIDEFYRPFEKEVAKAETEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVTCPQCQKGQVIERKTKRNRIFYGCDRYPDCDFTSWDKPVGRNCPKCDHYLIEKKVRGGGKQVVCSNGDYEEEKVK
(1017) DNA topoisomerase 1 [Sphingopyxis alaskensis RB2256]
1
MQLVIVESPAKAKTIEKYLGRDFKVLASYGHVRDLPPKDGSVDPDDGFAMQWQLYPDKAKRLKEISDAAKGADRLILATDPDREGEAISWHVQELLRSKKALPAAVDRVTFNAITKQAVTDAMRHPRELDTDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIEAFVAQQYWSVTGLFEMGGTPFKARLSRWRGDKIERLSITSEADARAAEADVKAGHFTVDTVETKPLTRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQALYEDGAITYMRTDGVQMDGSAISAARKAIATRYDGGYVPDKPRQYQTKAKNAQEAHEAIRPTDFGKDKVGGGDHARLYELIWKRALASQMASARLERTSVELSDGTGKTTLRATGQVVKFPGFLALYDEGRDDAEDEDARLLPAMAKGDAPAKTGVEVERHETQPPPRYSEASLVKKMEELGIGRPSTYASILQVLKDRDYVRVEKNRFIPEESGRLLTAFLERFFERYVGYDFTAELEEELDDVSGGRAQWQAVLERFWRDFKPRTGEVMEQKPSEITAALDEFLGPYLFPDKSDGSDPRLCPNCGTGRLALRGGKFGPFIACSNYPDCKFTRKFAQSGGNGEADNGPETLGTDPESGLEVTKRSGRFGPYIQLGEGSEAKRSSIPKDIPAEDFDLDYALRLLSLPREVGVHPESGKPIMAGLGRYGPYLLHDGKYAKLGGTAEIFDIGMNAAVVRIAEAANGGGRGRAKAEPLNTFGPHPTSGGEMKLMEGRYGPYVTDGTTNATLPKTTDPATLTMEEAIALIDARAAKGPVKGKKKAAPKKKAAAKKAAAKEAPARKTAAE
(1019) DNA topoisomerase 1 [Thermosipho africanus TCF52B]
1
MSKKKKVIIVESPAKAKTIEKILGDEYKVISSKGHVRDLPQKKFGVDLNNFEPEFEIIPGKENVIESIKKEIKGKEVLLASDMDREGEAIAWHLSQIFNLKGKNRIVFTEITPNTIKKSVETPREIDIKKVNAQLARRILDRIVGYKISPLLWKIIKGAMSAGRVQSAALKIICDRERERFLFKPKEFYKVSINVKKVKANLWSIKGKKIKQENITKEIAEDIKNNVKEVTLSDIVEKERKKSPPNPYITSTLQQDAATKLGFPVSKTMKIAQALYEGIDTKEGHLAFITYMRTDSTRVSEEAKQMAQEFIEKNFGKEYIGGSKNKKKTSKNVQDAHECIRPVNPEITPDIAKSLLSSDYYKLYKLIWERFMASQMKESKYKERTYIFQSEKYEFRTTYSHLIFDGFEKIYNSSSKEEEKIDLEKGKTYKVSKINIEKDTTKPPARFTEASLVKTLEAEGIGRPSTYATIISTLLARKYVKKENKELIPTLLGFTVEDFLTKRFPEIVDKKFTALMEEELDKVESGEKEWKEVLDNFYSEFSKYLSTAQKEFYTIDYETDLPCKDCKEENYKLKIGKYGLYLNCEKCKTNKSVDNTINAVLIENKMFIAQALENHENETVSENSCPKCGGHLLRKKGRYGYYFKCDNCDFTVSGYKIAQAKCPKCGSLVVMRRSKNGKTYWTCTNSDCDFMSWTEPKNEE
(1023) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-rat-Yit]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVNIEDDYEPNYINVRGKADLIKSLKKYSKKSEKVFLATDPDREGEAISWHLAYILGIDLSEKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINNFEVKQYFTIEGTGRKNSKKYVFKLHSKNKEKLDELTKDRVSEILDDLSKGKYVVDEVKEGIKNKYPLPPFTTSTLQQDAYKKLNFQTKKTMSVAQSLYEGVDIKGYGVVGLITYMRTDSVRLSSDSLNQANEFVKKVYGDKYKLDKPRQYGKNNKNIQDAHEAIRPTNVEITPEIAKQTLKDDQYKLYSLIWKRFLASQMANAVYNTMSISIKNNGYLFKLSGSQLKFDGFLKVYEIDKDDKDLILPIFEEGEELNNIKIESVEHFTQPPSRYTEASFVKLMEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIDFTADMEKKLDGIEEGKVDWKNIVHEFYKPLKEKIDIAENTVEKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSITQKLNVSCPKCGGEINVRKSKKGKVFYGCNNYPECDFVSWNEPSDVKCSRCGGITVKKIKRKQEVYECIDENCKE
(1025) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(1026) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(1027) DNA topoisomerase 1 [Ruminococcus obeum A2-162]
1
MAKYLVIVESPAKVKTIKKFLGSNYDVQASNGHVRDFPKSQFGIDVENDFEPKYITIRGKGELLANLRKAAKKADKIYLATDPDREGEAISWHLMQALKEDPAKMRRISFNEITKTAVKASIKQPRDLDLNLVDAQQARRMLDRMVGYTISPLLWVKVKRGLSAGRVQSVALRIICDREEEINSFIPEEYWSLDGEFKIKGEKKPLQAKFYGTDKKLPIHNKAEMDKILKALENAQYEITEVKKGERTKNAPLPFTTSTLQQEAAKTLNFSTQKTMRLAQQLYEGIDIKGSGTVGLISYLRTDSTRISQEADQAAREYIEAQYGDNYVSTTGKTVKKEQKIQDAHEAIRPTDITRLPAMIKESLSRDQFRLYQLIWKRFTASRMSAAKYETTSVKIGAGEYTFTVAASKIVFDGFMSVYVQEEDNQKGNVLSQSLEKGMKLELTELKPEQHFTQPPAHYTEASLVKALEEQGIGRPSTYAPTITTIISRRYVSKEQKNLYVTELGEVVNNIMKQAFPSIVDVRFTAMMEGLLDCVEEGTVQWKTVVRNFYPDLKRDVDAAEKELEKVEIQDEVSDEVCDVCGRNMVIKYGPHGRFLACPGFPECRNTKPYYEKIGVACPKCGKDVVLKKTQKGRKYYGCIDNPECDFMSWQKPSAKKCPKCGSYMVEKGNKIVCSETTCGYVEQKSKED
(1028) DNA topoisomerase 1 [Hirschia baltica ATCC 49814]
1
MQVVVVESPAKAKTINNYLGKDYIVLASYGHIRDLPSKDGSVDPDADFAMKWEGDSKSNKRIKDIADALKGADGLILATDPDREGEAISWHVLDVLSKKRGLMKDKKIERVVFNAITKKSILEAMQNPRSLDQELVDAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRLICEREVEIEAFKPEEYWTIKGLMDSVSKTEFEARLYELEGKKTQKFSFPNKEAADKALEVVRVGGYTVQSVEAKPVKSNPPPPFTTSTLQQEASRKLGFNASRTMGAAQKLYEAGLITYMRTDGVEMAQEAIHAARDAIKERYGAPYVPSSPRIYTSKAKNAQEAHEAVRPTDFLKHPSEVRLEADLQRLYDLVWKRAVASQMATAQLERTTADLKSKDGQAILRATGQVVKFDGFLTLYQEGKDDANGDEDAKRLPAMSVGDVIDLKKADANQSFTQPPPRFTEASLVKKMEELGIGRPSTYASTLATLRDRDYVEMDKNRFVPADKGRLVTIFLENYFNQYVQYDFTAELEEKLDLVSDGKLEWKVFLAEFWKQFSLKIAEVMELRVTNVLDLLNDVLGPKIFPPKLDEKTGEPTGEDPRLCPLCKEGQLSMKLGRNGAFIGCSNYPECKHTRPFTTDGSDAEDAVSPDGKLLGQDPETGKDISLRTGRFGPYVQLGEGIGKEKPKRGSIPKGWKADELTLAQAIQLINLPREIGPHPEDGEMMYANFGRYGPYVQHQKTYANLPDPMDVFEVGLNRAVALIAEKNAKGGRGGAAKALKELGKHPDTDEPINVFDGRYGPYVKHQKTNATLPKDLTPETITLEKAIELINAKAGASKKKAPAKKKAPAKKTAAKKAPAKKAPASDS
(1029) DNA topoisomerase 1 [Chlorobium phaeobacteroides DSM 266]
1
MALKSPAASARNRTLIVVESPSKAKTINKYLGDKYTVFASVGHIKDLPKKEIGLDFDHHYEPRYEVIAGKEKVVRQLKKLADESNEILIATDPDREGEAIAWHIANEVEFAHKPVFRVLFNEITKTAIIAAIQQPRQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVLRGLSAGRVQSVALRLICEREAEINGFQIQEYWSIAADFKTDLNETFRTKLIKIKGDKPELSNQKKAETAAAEISERLFAVKEITTRVQQRKPPFPFTTSLLQQAASNQLGFGSQKTMRIAQQLYEGIELGDEGATGLITYMRTDSIRIGTEATAEARNYITAQFGKEYVGYGGAAKAGKNAQDAHEAIRPTSLLRKPESVKHFLSSDQFRLYELIWRRLLTAMMAPAKIEQTRVDVEDREKEFTFRANGSRVLFAGFMRVYDDQQELDYEAQSSTRDDVEKEQTVQLPEKLKEQDKLGLAGLDSKQSFTRPPARYSEATLVKDLDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTELGKDVSLILVANFPELFNVGFTAHMEDELDKVASGDDEYEAVLEKFYRPLETALSLRKSDPIIPQNSATETCDKCGKGQMTVKWTASGKFLGCSRYPSCKNIKPLSSSKAKPKDTGIQCPSCKEGHMLLRDGRLGPFLACSSYPKCNTLLNLGKQRQVEPMKIPPLLTTLVCPKCGAPMNLRSGKRGLWLGCSKFPKCRGRLAWGTLDEEVQRHWETLMTEHQKAHPTVALTMIDGRPVPLTLSVDDIITRAEEAGLIAAVPEEQQELTAE
(1032) DNA topoisomerase 1 [Peptoclostridium difficile 630]
1
MAKTLVIVESPAKAKTIEKFLGKSHYTVKASVGHVRDLPKSKLGVDIENNFEPQYINIRGKGDVIKELKKEAKKSKQVYLATDPDREGEAISWHLAHILNLDESEDCRIEFNEITKDAIKKAIKHPRNIDINLVDAQQARRVLDRLLGYQISPILWQKVRKGLSAGRVQSVTTKLICDREKEIKAFIPKEYWTIDVEAKTVKDKDITLKFYGKNDEKIELENEEAVNEILKEMEGKDLKVEKIESKSRRKSAPKPFTTSMLQQEGANKLFFTTKKTMMIAQELYEGIDIEGEGTVGLISYIRTDSKRISDEAKEKAKGYIVNNLGENYYKNTGDKKEKKDTKKVQDAHEAIRPTSVDRTPESIKASLSKDQYKLYNLIWRRFVASQMEDSVFDILNVECKIGDIVFKATGSKMKFDGYTKVYNFSEREDKILPSIEKGDILNIENILPDQHFTQPPARYTEASLVKTLEELGIGRPSTYAPTIATILNREYVEKQGTSLCPTELGIIVTDILENNFHKFIDVDFTADMESKLDVIEEGNTDWKKIVSESYAPLKEAIEEALENIEKVNMDEETDEICENCGSNMVIKYGRFGKFMACKNYPDCKTTRPIMNKIGVKCPKCEEGDIILRKSKRGKAFYGCSNYPNCDFVAWNKPTGEFCEKCGSYMVEKVTKSETKTVCSNKECNKETKEHNDGKE
(1034) DNA topoisomerase 1 [Leuconostoc sp. C2]
1
MVEPGKVAKKPAAKKTTKRKKSKNQKKLVVVESPAKAKTIEKYLGSTYKVVASLGHIRDLPKSTLGVDVDNDYDPKYINIRGKGDLIKGLRKEAKAAKVVYLASDPDREGEAISWHLQHILGLDPDQPNRVVFNEITKDAIKNAFKTPRKINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIAREREIQAFEPEEYWSLDSEFQKSRQKFKATFYGFDAKKQVLPDNDSVQSVLKNIDQSADFDVMKVNAKERKRNPQPAFTTATMQQTANTQLNFRTRKTMMAAQQLYEGINLGRGIGQIGLITYMRTDSTRISSVARHAAAVYIHDTWGEEYSQHKLVQGKLPEGAQDAHEAIRPSDVTITPSSIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNGVIFRANGSKTKFQGFTKAYPAAKEKDNALPDLAEGDRVKLANINPEQHFTLPPARYSEAALIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVENSFPDVTNMKFTARVEHELDEIETGDKQWVPVIDSFFKPFSKELEIAETTLEKVVMHDELAGMDCDICGAPMLVKMGRYGKFHACSRFPDCRHTQTIVKEIGLICPKCGKGQIIERKTKRQRTFYGCSRYPDCDFVSWEKPTEKTLPDGTTPKDDEMSDGQQNSQQPTDNKEEAT
(1036) DNA topoisomerase 1 [Zobellia galactanivorans]
1
MAKNLVIVESPAKAKTIEKFLGKDYKVESSFGHIADLPSKELGVDVENDFKPKYIVDKDKKALVKKLGDLAKKAETIWLASDEDREGEAISWHLAETLGLDKNKTKRIVFNSITKSAIQKAIENPREINYNLVNAQQARRVLDRLVGYELSPVLWKKIKPGLSAGRVQSVAVRLIVERERDIEAFTAEASFRVSAEFKTLEGSVFTAKLNKTFPTKEEAQAFLNENIGADFSVGNLDKKPAKKSPSAPFTTSTLQQEASRKLYFSVGRTMQVAQRLYEAGLITYMRTDSVNLSGEAIAAAKDAIIDNYGEKYSTVRNFKGKSKGAQEAHEAIRPTDITNQSPSLERDQSKLYELIWKRTIASQMSDAQLERTNVKIKASTHSELFTANGEVIKFDGFLKVYMEGLDEEDVAEEQEGMLPAMKVGEALKNNYITATERFSRPPYRFTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTVEGTERNYVQLLLEAGAVKEKKLSEMVGSDKGKLVPTDIGMIVNDFLVSHFATILDYNFTAKVEEDFDEIAEGEEDWQKVMRDFYKDFHPNVLDVQENADRASGERILGEDPKTGRQVSVRLGRFGPMVQMGTVDDEEKPKFASLLPEQSLTTITYDEAMELFKLPRKLGVYEGEEIEANVGRFGPYVRFGKKFVSLEAGESAFDVNFDRAVELIKQKQKADAPIYTYEGKEVTKGTGRFGPFIKWDGMFINVNKKYDFDNLSNDDLIELIEAKKQKEIDKVVQNWPEEGIRIEKARWGRHNIIKGKVKVELAKTVDAAKMSLDEAKKMIEQKTPKKKAKAKPKAKKK
(1037) DNA topoisomerase 1 [Clostridium tetani E88]
1
MIMGQKLIIVESPAKAKTIGKYLDKTYHVEASMGHIRDLPKSQLGVDIDNNYEPKYITIRGKGELLTKIKKHAKKCDEIYLATDPDREGEAISWHLSQALKLEDNKKCRIVFNEITKSAVKNAIKEPREIDIDLVNAQQARRVLDRLVGYKISPILWRKVRWGLSAGRVQSVVLKMICDREKEIEEFIPKEYWTIECKLNKDRKDFLVKLISKDNKKIEINTEEESNNIIKELKQGQFTVDKIKKTNKNKNPLPPFITSTLQQDAYRKLNFSTKKTMSVAQQLYEGIDIKGHGTVGLITYMRTDSVRISKEAQNKARQFLENVYGKEYIPEKPRDYKGKKNIQDAHEAIRPTNIEITPKIALENLNSDQYKLYSLIWNRFMASQMAACVMEVNSVDVKNSEYIFRATGSIVKFDGFMIIYEYLNEDEKENINIPKLEKGELLKEKSIDSKQHFTQPPGRFSEASLVKVLEDNGIGRPSTYAPIISTLLERTYIERENRTLKSTELGVIVNNIMVEYFKPVVDAEFTAEMENKLDSIEEGNENWKNTVDEFYSPLKELIETAEKEVEKVTLEEKVTDVKCEKCGNNMVVKHGRFGDFLACPGYPECKNTKPIVHQLDVKCPKCHGEIVLKKSKKGRKFYGCSNYPKCDFVSWFEPVERKCDVCGNYMVKRYTKAKGDYIECSNKECKHKIMPEKKQE
(1039) DNA topoisomerase 1 [Desulfotomaculum carboxydivorans CO-1-SRB]
1
MGCTNLSKTLVIVESPAKAKSIGKYLGRNYTVKASMGHLRDLPKSQFGVDVESNFSPKYIAIRGKGEIIKELRAAVKKADRILLASDPDREGEAIAWHLSKLLDIDENSNCRIEFNEITKQAIQQAVKHPRPIDIDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLIVDREEEIKAFIPEEYWSLTAKFSKTAKSTFEAKLYKYQNKKITIPNQEAMDKILADLKGVSYVVASVTRKEKLRNPAPPFTTSSLQQEASRKLNFTARKTMAVAQQLYEGLELGKEGPVGLVTYIRTDSTRVSETAVEEAKKFILERFGPAYVPKESRQTVAKGKVQDAHEAIRPTSVERDPETIKEFLTNDQYKLYKLIWSRFLASQMAAAVMDTTSMDIEGGDYLFRATGSIVKFPGFMQVYIEENDDGTKEEEKLLPELAQGDKVEAKSLTPKQHFTQPPPRYTDATLVKVLEEKGIGRPSTYAPIVETIQKRGYVVRENKQFYPTELGIIVVDLLKNYFPDIINIEFTAEMEEKLDQIAEGDQDWVNVLKDFYGPFQQTLATAEEKIGKVQVADEVTDEICEQCGKNMVIKMGRFGKFLACPGFPDCRNTKPLLEPTGVACPRCEGELVLRRSKKGRKFYGCSRYPECDFVTWDVPTNEKCPHCGDLMVEKSSRGKEKILQCVNENCPSNAGVKETKAGQKTKQTTSNK
(1040) DNA topoisomerase 1 [Clostridiales genomosp. BVAB3 str. UPII9-5]
1
MDKTLVIVESPAKAKTIGRYLGKDYEIAASVGHIRDLPSSTMGVDINNDFKPRYINMRGKEKIINDLKAKAAANAHTLIATDPDREGEAIAWHLANVLHIDPLSLCRITFNEITKNTVKTAVEQPRAIDLDLVNAQQARRILDRLVGYELSPLLWSKVKKGLSAGRVQSVATLMLVEREEAIRSFEPQEYWLLSVHLAEEKQPLADFTAQFYGRLDASGKCVKEELPDASAVENIKKQIQEPYKVLEIVKRNRQRNPAPPYTTSTLQQDAARKLGFSAKKTMLIAQQLYEGVDLPELGATALVTYIRTDSVRSSADAVAGMRKIIVSTFGPEFVPAEPNHFKNKNAAQDAHEAIRPSHLELPPEKIKVGLSTEQYKLYRLIWERFLASQMTPAKLAATTINIAAGDIIFRVTGETVIFPGFLKVNPEKVAEKEMNILPDLEKNETLRKLELLEEQKFTQPPARYNEASLIKAMEEAGIGRPSTYAPTLSTIMERQYAVKENKSLIPTELGFLVTNILREHFKKLINIKFTAEMENDLDEVESGKLNWVELIKNFYPVFHAAIVKAQKDISKIVIPVEATGEKCPECGADLVIKEGRFGKFIACSAFPNCKFTKNAVEKVDGHCPRCGSDLVSRRSRRGSIFYVCSQNADDKNCDFISWDLPVDNEKCPECGSYMVWHRLRGRLYKRCSNDSCVTRKSKRGKTDKNVAGEKQANDTAEPSAVETKRRKNTPKEKKKDND
(1043) DNA topoisomerase 1 [Methylotenera versatilis 301]
1
MSKLLIVESPSKAKTLKKYLGSDFEVLASYGHVRDLIPKNGAVDTANDFAMKYDIIERNSKHVDAIAKAVKSADSIYLATDPDREGEAISWHIAEILKSKNLLKNKVMKRVVFHEITKSAVEHAIAEPRDISMPMVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLDALKHSHGFTAKLIQLNNQKVEQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTLQQEAVRKLGFTTSRAMRVAQQLYEGMDVGSGTVGLITYMRTDSFSIAAEAIAQIRDYVKKNFDAEYLPKAAIQYKTKSKSAQEAHEAIRPTDISRTPASVRQYLTDEQFKLYEMIWKRALACQMAPAKFDAVSVDLSVGSDANLFRASGQTLVFPGFIAVYMEGTDDEEEEGESKLPHLETGEVLTVEKIYGDQHFTEPPPRYGEASLVKILEEYGIGRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTKYVDYGFTANLEDALDSVAEGEREWLPLMAEFWQGFNQQLLSKADVERPGNELIDEACPKCGKPLQKQLSRFGTFIGCTGYNDEPKCDYKRSLNGAAQVGSDPIIIGNDDESGKEIMLMNGPYGPYLQLGLAVEGDKKKPKRVSVPKEISLADMNLETAKMVLSLPRDLGLHPVTNKKIVANIGRFGPYVNHDAKFKSIPKTDSVFTIDLDGAVALLAAAHTGPAPLATLGNHPTEDGQIEVFAGRYGPYVQHGKIRATLPKSVEPESLTLDEALELLMAKAQKEAPAKKTTTKKPTAKKAPAKKPAAAKATAKKPAATKTATKKPAAKKAAVQ
(1044) DNA topoisomerase 1 [Candidatus Chloracidobacterium thermophilum B]
1
MTKGLVIVESPAKAKTITKYLGKDFTVLASYGHIKDLPEKELGVDVEHGFEPTYEIIPDTKKRNNSKTVRELKSAARKAESIYLAADPDREGEAICQHLREELVGDKEQKPVYRLLFNEITKDAIQASLQSPRQINQALVEAQQARRVLDRLVGYEVSPMLNRGLGGGKVALSAGRVQSVALRLVVEREREILAFQPTEYWTFDARFAAALPPEFTAKLFSIHGETLKTGDFDKQRRNERHVRTEAEARDLERQLREVAEWRVAAVTTREKKRHPVAPFITSTLQQEASRKLSFPVKKTMSLAQKLYEGIELGAEGSVGLITYMRTDSTRIADSAIAEVRDFIAAQYGANRLPAKPNQYKNKKGAQDAHEAIRPTSVWRTPEKVAPYLEADELALYRLIWQRFVASQMTPALFDATTIDIEGGPGFVFRATGAVLRFDGFLAVYEEGKDELDADDEALARKLPQVAAGERVECRELQVNQSFTRPPARYTEATLVKTLEERGIGRPSTYAQTLSVIQARNYVEKRDGRFHPTPLGMVIADVLTENFADLFDPGYTAVLETQLDEIEEGKLNWREALEEFYRKFRADLEAAKANLKKAKEGVATDERCHKCGAAMVLKLGRFGKYLACTNLECRATRDYGTLPTATSDPGTAAEAVGEIACDACGRPMVRKRGRWGEFLACTGYPECKTTRNLTRTGAPKPAPVQLDEACPTCGQPLAVRQGRYGEFIGCSNYPKCTYIKREAIMPCPRPGCGGDITERRSGRGRVFYKCTNTACDVVYWDKPVTHPCPSCGAPFTLQKTNAQGETYHYCADKEHCGWTELPAEKRKKKDTLPASKNPSASEAA
(1046) DNA topoisomerase 1 [Arcobacter nitrofigilis DSM 7299]
1
MKNLVIVESPAKAKTISKFLGSEYKVMASMGHVRDLPKSKLGFDPADNFKPQYLISTDKRKVIADLKKEITKDTTIYLAADEDREGEAIAWHLIPALKVEKNPLKRIVFHEITKGAILKALENPREVNQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFIPEEFWKIKADFINPQLNTELAKIDGKVKKIKNEQEAKVIEASINQGEFELFDIDESESKRNPAAPFTTSTLQQEASRKLGYSVKQTMVIAQQLYEGNIQNIPNHTGGLITYMRTDSLNLSTVATSAAKEVIEKTYGAEYSLKSPRVYKSKAKGAQEAHEAIRPVDLSLKPSMIKAYVDNAQFRLYSLIWKRTLATQMQTAKIANTTYKISAGKDKEYEFQVKGQRIIFPGFMKVYTEGSDNPESALDSSEKILPSIKVGTKLDLEKLDLEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYITKSEDKKLIPTPTGEIVNSFLTDHFPNILDLGFTAKVEEEFDDIADGKIAWQQVMKDFYGDFKKTIDEKEESVNKEDYLQIREIGTDPKSGKPVSARVGRFGPFVQIGTKDDEEKPLFVAIPAHLNMDTITMDEAMFLFTLPRVVGQTADGEDIKANIGRFGPYLQVKTKYYSLKEDDPYKIELPRALELIKQIDEEKAKATIKNFEKEKIQVLDGRYGPYIKQGRKNYKIPKGKDAASLELEDCLSIIENDSKTSKRAPAKKTAAAKTTTKTATKKAPAKKAPVKKTTTKKTTAKKEK
(1050) DNA topoisomerase 1 [Thermosynechococcus elongatus BP-1]
1
MSTLVIVESPAKARTIRKFLPPDYRVEASMGHVRDLPRSAADVPPEFRGEEWATLGVNVAAGFEPLYIVPKEKQKVIKELKAALKTADELLLATDEDREGESISWHLLQLLEPKVPVRRMVFHEITEEAIQEALHNCRDVNQQLVRAQETRRILDRLVGYTLSPLLWRKIAPHLSAGRVQSVAVRLLVQRERERLAFRKGQFWDLKATLDQRGTLFPARLVSVGGQRLATGNDFDPTTGQLRNPDAVLLLDEAAANALRDRLLTETWTVTEQEERQQTRKPAPPFTTSTLQQEANRKLHLSAQETMRIAQKLYEEGYITYMRTDSVHLSDQAIAAARSCVEAMYGKAFLSPQPRQYTTKTKGAQEAHEAIRPAGSQFRTPQETGLRDRELELYELIWKRTVASQMADARVTLLTVSITAGDALFRAHGKRIDFPGFFRAYVEGSDDPDAALESQEVMLPVMQVGDILRCQALESVRHETQPPPRYTEASLVKALEQAGIGRPSTYATIISTIQDREYAIRRGNALEPTFTAFAVTALLEKYFPDLVDINFTARMEQTLDDISTGEVQWQPYLESFYLGENGLEQQVKERERTIEATEARAIALPELNAEVVVGRFGPFVVYQNGNGSEPIKASLPQDATPGSLTREQVEQLIRQKLEGPDKLGVHPETGEPIFLLTGRFGPYVQLGEATEANPKPKRASLPKGVSPDEVTLDLAITLLSLPRTLGVHPETGKLIQANQGRFGPYIVHDPEGEKDYRSLKGEDDVYTITLERALELLATPKSSRARAKKQVLAVVGTHPEDGKLVQIFDGPYGPYVNHGKVNASLPEGVTPETMTLEQALLLLAEKAPKKTRRSATATAPKPKSTIKRTSKKTATQTANTSRRKSTET
(1051) DNA topoisomerase 1 [Paludibacter propionicigenes WB4]
1
MSKNLVIVESPAKAKTIEKFLGTDYHVMSSFGHIRDLADKGIGIDFENNYEPQYVVSTDKKKLVSELKKASKDAETVWLASDEDREGEAIAWHLYEELKLKKDSTRRIVFHEITKDAILHAIETPRDIDVNLVDAQQARRVLDRIVGFELSPILWRKVRPSLSAGRVQSVAVRLIVEREREISQFVPEASYRVNAIFSSVDSKGKPVELKAELPQRFATKVEALAFLETCIKAEFSVDDIVKKPAKKSPAPPFTTSTLQQEAARKLGYSVAQTMQIAQRLYEAGKITYMRTDSVNLSDLALGTSKAEIISMAGEKYVHIRKFNTKTKGAQEAHEAIRPTYMNAHTVEGTAQEKKLYELIWKRTIASQMSDAELEKTSIFISVSGSNLQFVASGEVIVFDGFLKVYMESTDDEQDTENESLLPSMKKGEKLSSVEIIAQERFTQKPPRYGEASLVRKMEELGIGRPSTYAPTISTIQNRSYVEKGDRAPEKREYNLLKLKAGKISDKIKEENTGAEKSKLFPTDIGTVVNDFLIEYFPEILNYNFTADVEKEFDNIADGKIKWTKSIDKFYKKFHPIVEDTMKNSERKVGERILGVDPKSGRQLSVKIGKYGPLAQIGTVDEEEKPVFASLRKEQSIESISFEEALELFKLPRQVGEFEGKVMTVAIGRFGPYIRHDSSFYSLPKTDDPMEVSTERAIEIIEAKREVEKNRIIKTLGENNEIQVLNGRFGAYFTFDGVNYKIFPKGTDPATLTFERCQELIAAQPEAANKKKPFGRKAAAKSDKKEKAQTKAKTTKAKATKAKK
(1052) DNA topoisomerase 1 [Orientia tsutsugamushi str. Ikeda]
1
MKLLIVESPAKAKTINKYLGSDFQVVASYGHVRDLLAKAGSVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATDPDREGESISWHIVEVLKEKKIFANFKRIIFNEITKKAIGDALQQPRDINLNLVNAQQARRSLDYLVGFSLSPLLWRKLPGCKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKLIEFDGNKLEKFSITNQSQAQDIVKNIENQQFKVIDITRKQRKKSPPPPFITSSLQQEAAGKLGFTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNFISSSFGSNYLPKQIRAFKSKVKNAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQRTVACQMENVILNLESINFASFNQLHVAKATGSTIAFDGFYKVYKEINDEEENKKLLPNLSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLGIGRPSTYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSIAKGMIEWQEILKNFWTGFNNNVQEIEQYKITDIIPQIETLLSNFLFPAQNDETDHKLCTLCKVGKLSLKLSKYGAFLACDNYPSCNFTRNIAAAFENNDNLPKGKNNKAIGYSDDMQKTIYLKEGPFGWYIQAGEDSTNKNDKPKRVPISVISSSPQDITLETAVKLLALPKVIGLNPNTNKEITVAVGRYGPYLKHDGKFISIPKNYDYLNLSINDCIKIITSSSSQLRKAKKDAPTNSDKVAKSKS
(1053) DNA topoisomerase 1 [Rickettsia prowazekii str. Madrid E]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDKNFLMEYDISDKAGKYVDAIVKEARKAEVVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIMNAVANPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICDREDEIERFKSEEYWDISLKMQNSNNDLFTAKLTHVNDQKLKKFSIINEKEAKDLTQKLKLQKFYVEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGNQYLPIKPRIYQSKVKNAQEAHEAIRPTNITYTPDSLKQKLEKDYYKLYELIWHRTIACQMENVIMDLVIANLASENKEYLAKANGSIIAFDGFYKVYRESLDDEDEEDNKMLPPLKEQEHIKTKEVIPNKHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKTALNNFWRGFNHNIESVNEQKITEIINYLQKALDYHLFGEDKESKVCPSCKTGQLSLKLGKFGAFLACSNYPECTFKKSIVSGNDNNEDEGDPSTILNDNKILGTDQDGVEIYLKKGPYGPYIQLGEQCGKVKPKRTPVPANLKQSEITLEIALKLLNLPLKIGIHKDSGEEIIIGYSKFGPYIKYMCKFISVPKKYDFLNLSLNDAMKLIQNNKAKLEKKYG
(1055) DNA topoisomerase 1 [Methylobacterium extorquens AM1]
1
MKVVVVESPAKAKTINKYLGRDYEVLASFGHIRDLPAKDGSVDPEADFAMIWEVEDRGAKRVSEIARAVKGAEKLILATDPDREGEAISWHVIEALTARKALKGIPVERVTFNAITKASVDAAMKKPRQIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWSIIATLVTEAGGVFEARLVGADGKRIQRLDVGNAEEAAAFKRDLELATFQVASIEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDVGGETVGIITYMRTDGVDMAPEAIQDARQVIGREFGDAYVPSAPRKYTVKAKNAQEAHEAVRPTDMGRLPKHVARHLEPEQAKLYDLIWTRTIASQMESAELERTTVEVSANVGPRRIDLRATGQVVKFDGFLALYQEGKDDEEDEDAKRLPAMKAGDALKRERIASTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVRIEKKRLQPEDKGRLVTGFLESFFKRYVEYDFTASLEEQLDRVSNAEIDWRSVLRDFWRDFSAAIGGTKELRVAEVLEALNGLLGPHIFPEKADGGDPRACPTCGAGQLSLKLGKFGAFIGCSNYPECKYTRQLSASGVEGEGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFVQLGEASAEKGAEKPKRSSLPKGTTPGSVTLEIALRLLSLPREVAKHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRPSSDPGRTLGQHPDGAALVVKAGKYGPYVSDGSVNATLPKTMAAESLTLEQAIDLVNAKRASGGGKKPVRKTASRARAPAKKAEAGEAKKPAVRKTAAKPAAKATATKAAAKPAAAKKATAKTKAG
(1057) DNA topoisomerase 1 [Candidatus Liberibacter solanacearum CLso-ZC1]
1
MNVIIVESPAKAKTISKYLGPDYKVLSSFGHVRDLPAKKGSVLPEKNFEMLWETDKSSQKHLENIISAVKSSTLLILATDPDREGEAISWHVLDILRQRNLIGERKIKRVSFNAITKKVVLNAMENTRDLNLDLVNAYLARRALDYLVGFNLSPILWRKLPGARSAGRVQSVALRLICHRENQIECFVSEEYWLLSVLLETPRGDKFIARLVDFNGQRIEKTSIGNKKEADKLISFLEKATYIVKNTETKPIKRNPWPAFTTSTLQQAASSRLGFSPSYTMRIAQKLYEGIDVNGEVVGLITYMRTDSVHLSLDALEEVRRSISSNFGNSYLPDKPRIYSVKAKNAQEAHEAIRPNDFNFLPSEMKKFLDSDQFQLYNLIWKRSVASQMASAEFERTTISIDATYEDQIAHLRTVGSCLRFDGFLKVWENQNDQENNSDEDKLLPCINKNEKLLAKETNASQHFTEAPLRYSESSLIKKMEELGIGRPSTYAAILETLSKRRYIVIEKRKLFPQNTGRIVTAFLENFFSRYVEYDFTADLEEKLDKISSGKLDWKEVLHEFWKEFIEKIDSTKELRTSNVLDILNDTLSSVIFPAKDNNEDSRTCPSCQKNPLSIKLSSKYGAFVGCTNYPECKYTRQLTTSNQQYIEENLEPLLLGDDPETKEPITLRSGRFGFYVQRGDGKDAKRCGLPKNWDRESIDYDKALSLISLPREIGIHPETQKSIIASMGKYGCYLKHDGHHTKLESIEQVLTINLDQAISCMIQKNKKEKSSRTSTKNQGHVIGIHPEGGSITIHRGRYGPYLNWGKINASIPNNENPDTIDLENALKIFETKIKGKKKS
(1058) DNA topoisomerase 1 [Geobacter metallireducens GS-15]
1
MPQHLVIVESPAKAKTIEKFLGKDFRVMASYGHVRALPSKQGSVDVANDFEPKYAILPESKRHIDAIKKELKESDILLLATDPDREGEAISWHLLAALGMDKKKNAVPVKRVVFHEITKDAIVHAVENPRDISLELVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIKAFQEQEYWTIGAELGTGKGQKFSANLVEAEGKKLGKFDIPDGTAADRLVKALENGAYTVDKVAKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGVAVGDEGLVGLITYMRTDSVVLSNQALQEAHEVITSLYGKEYALAKPRFYKNKAKNAQEAHEAVRPTSIARTPVEVKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGYRFRAAGTVIRFPGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLQKLVPEQHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLLERKYARLDSKRFVPEDVGMVVNDLLTNHFTQYVDYNFTASLEEELDRVSRGEKQWKPLLHDFWGPFSSLLKQKEGEVSKADLTTEATDELCPDCGKPLVVKLGKRGKFIACSGYQEGCTYTRNIAQGEQQEPAEPVFSEEKCDKCGSPMLIKDGRFGKYLACSAYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPGPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
(1059) DNA topoisomerase 1 [Deferribacter desulfuricans SSM1]
1
MSKNLVIVESPAKARTIEKYLGKDFKVMASVGHVKDLPENELGVDIENGFKPKYRVIKGKKKIIDALKKEAEKSDTIYLAPDPDREGEAIAWHIAEEVKKKNPNIKRVEFHEITKKGVAEGISNPKDINIQRVNAQQSRRILDRLVGYLVSPLLWKPLKYGLSAGRVQSVALRLICEREEEIEKFVPKEYHLVDGIFLCNNHEIKARLEKKNGKKFELNTQEQVDNFKKEIKDHEFYVSKVEKKEVKQFAPLPFITSTLQQEAARKLSFSAKKTMMIAQQLYEGVELGAEGPTGLITYMRTDSTRVSDDAKSEAQNYILKRFGEKYCSNEKRVSKKKQNVQDAHEAIRPTSVLREPESVKNYLTQDQYKLYKLIWERFVASQMAPAIFDKSTIEISDGVYTFVARGKILKFDGFMKLYVEGKDNESENDEEGIIPDVKESDLAILKEIVSKQMFTSPPPRYTEATLVKALEQKGIGRPSTYATIISTIVDRGYVEVKERRFYPTELGRIVNKLLTTNFPKIFDVKFTAEMEKDLDQVEKGEIDWKKVLSDFYSSFEQELKKAENKLVMDLRIDKKCPECGSDLIIKYGKNGPFVACENYPDCKYSSDFKRGENGLIELVERKNGESTGLKCEKCGSEMVIKKSRFGEILACSGYPECKNIKNFIRLKDGIKVIEKNEKIDEKCPECGGNLFIKKGKNGLFLGCENYPDCKFTANFRVEDDKIIPVIKKIDDITCEKCGGKMVLKRSRRGSFFACENYPECKNTKSAITLEDGTITVKK
(1066) DNA topoisomerase 1 [Nitrosococcus oceani ATCC 19707]
1
MSKNVVVVESPAKAKTIKKYLGKNFEVLASYGHVRDLMPKEGAVDPEHGFKMKYQAIEKNGRHVNAIAKALKSADFLLLATDPDREGEAISWHLLELLKEEGVLEDKAIQRVVFYEITSQAVNEAVAHPRDISLDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIDAFKVREYWTLEADAAASKQEFVAKLTHLDGKKLAQFDIESKDQALALVDRLTKAASGELRVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSTKRTMSVAQQLYEGVDIGDGAIGLITYMRTDSVNLANEAVGEIRNFITERFGQSGLPAKPRTFKTRAKNAQEAHEAVRPTSVYRVPEALKPHLKPEQFKLYQLIWRRTIACQMKHATIDTVAVDLNTQKLAPEGGNSASGHIFRATGSTVVDPGFMAVYQEGRDDIKGEEEQRKLPPMKEGDRVTLLQIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRDYAVLENKRFQPTDVGRVVNRFLTEHFNSYVDYDFTARLEDELDAVSRGEKVWIPVLEEFWGPFSARIQEKEQNVSREEAVQARELGIDPQSSRPVSVRMGRYGPYIQIGSKEDEEKPRFAGLQPGQKMDAITLEEALTLFKLPRELGFTPGGEQVSVNVGRFGPYVKYDNKYVSLRGEDPHTISLERALALIEEKKQADANRVIKVFPDSGIQVLNGRYGPYVTDGERNARVPKEQAPEALSLEQAQALINEAPVKRARRKAGTRKKAKG
(1067) DNA topoisomerase 1 [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
1
MPATAKEDKSKSSKKTTAAAKKSSPKRKKSKVKKDLVIVESPAKAHTIEKYLGRKYRVIASKGHIRDLPKSQMGVDIDHDYQPKYISIRGKGDTIKELKAEAKKANKVYLASDPDREGEAIAWHVAHVLGLDEKEANRVTFNEVTKDAVKDAFNHARTIDMDTVNAQQARRVLDRLVGYSLSPILWSKVKKGLSAGRVQSVALKLVIDREKEIKAFKPVEYWTIDAEFAKGKDKFQASFYGEEGKKTELPNNEAVQKLLAKFDKKQPFTVSKVVKREVRRQPAAPFTTSTMQQEANRRLNFRTSKTMNIAQHLYEGISLGKEGTVGLITYMRTDSKRISPVARQEAAQFIVEEYGSDFAVKKERHFKNQGDAQDAHEAVRPTSVYRTPKSLEKVLTKDELRLYTLIWSRFVASEMTPAVFDTVRYDLTQNGVTFRASGSVMKFAGYTKVYDNRSEKNVALPALEEGDEVKLTKSDNKQHFTQPPARYTEASLVRALEENGVGRPSTYAPTIQNIQSRNYVKLEGRAIVPTELGEIVDGLVEQFFPDITSVDYTAKLEDELDEVEEGKKDWVSVVDQYYKPFSKELEKADSEIQKIQIKDQPAGFDCEVCGAPMLVKMGRYGKFYGCSRFPDCRHTQTIVKKVGVTCPKCGEGEVLEKKSKRGRKFYGCSRYPDCDFVSWDKPISRVCPHDGHFLVEKKRKDGMVVLCPNGDYKEEPREEQGEAAE
(1069) DNA topoisomerase 1 [Borrelia garinii BgVir]
1
MQNKKLIIVESPTKAKTIKKFLDDSFLVEACIGHIVDLPNNAKEVPKEYKKYEWANISIDYNNGFNPIYIIPSNKKPIVSKLKKLVKTINEIYLATDQDREGETIAFHLKEVLKIKNYKRMIFHEITETAITESLKNTRNIDINLVNAGETRRILDRLYGYTISPLLWKKVAYGLSAGRVQSVGLKLLIEKEKTRINFKKANYYSISLQCKHDKKDLLLETKLEEIDGKNIAESKDFINETGKLKNSDKTIIITHDLMIELEKELENGQKIELISIETKKIKIPPPKPFTTSTLQQEINKRLKIGTKQIMQHAQKLYEHGYITYMRTDSHNIAKIARDKITKIIKNKYGKEYVEEKDRIYEKEKMAQNAHEAIRPSEMFIPNENIEIEGKTAKEIYKIIWDRTIISGMKDAIKENIKLTFKYKNLIFKSSFTKVIFDGFLKHTKEKDEYPNINFDLMKKGDIFYIVKMKTSEHETKAPFRYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNTLIPTVKGAAVINLLEKYFPVLIELNFTSNMEEKLDKIAIGKLDKIKYLSKFYNGKKGLKDTVMRLEPKINSSEFRTVIESQNVENKDNDINYTINIGKYGPYLIFKGHNYSINTTTPLENLYKKDEIEKIINEKELKPNILGVDPLTGLNVIFKNTIYGNIVQLGEDTYAHQEYTKKGKPKKLKIIKAKKASTKKIDPENITLELALKLLSLPKPIGKHPQTNEQIIAATGVFGDYIKTESGSIACSLKKDVKAYDITLDRAISLLDERVNKVGIIVKTITFSKNKIGNKIYIYKKNDKFYAKIKRKKIDLPDNINLDEINEKYVFSLL
(1072) DNA topoisomerase 1 [Cyanothece sp. PCC 7425]
1
MSTLVIVESPTKARTIRNYLPPEYRVEASMGHVRDLPKAASEIPAEVKQEKWANLGVNVEADFEPLYVIPKDKKKIVKELQDALKNVDRLLLATDEDREGESISWHLLQLLRPKVPAQRMVFHEITQEAIQAALQNCREIDERLVHAQETRRILDRLVGYTLSPLLWRKIPQAKETDRKLSAGRVQSVAVRLLVNREQQRRLFRKGSYWDLQATLAQHQSPFEARLVNLNGKRLATGSDFDENTGQLFPDRDVVLLNETQAQELQARLQEQTWRVTQLDERPQTRKPAPPFTTSTLQQEANRKLRLSAKDTMRIAQGLYERGFITYMRTDSVHLSEQAIAATRSCVEQMYGREYLSPQPRQYTTKSKGAQEAHEAIRPAGSSFRAPQQTGLEGADLELYELIWKRTVATQMAEARQTLITVQIQVENAGFRANGKRIDFPGFFRAYVEGSDDPDAALENREVILPPLQPGDTPTCRTLEAIAHETQPPARYTEATLVKTLESEGIGRPSTYASIISTIIDRGYAYRQGNALVPTFTAFAVTRLLEKHFPDLVDVGFTARMEQTLDDISTGGVDWLPYLRDFYLGENGLEHQVKEREVQIDPVEARTVELPGLEAKVRIGRYGPFIEVDNGTEPVTASLPLDITPANLDADQVELLLKQKLEGPDKLGIHPETGEPIYLLLGPYGFYVQLGDVSETNKKPKRAALPKGVDKAEVNLGLALDLLSMPRALGLHPETGGKISVGLGRFGPYVLHDQGKDNKEYRSLKKEDDPFTLSLERALALLAEPKTGRGRRSKTKEPLRELGPHPADGEPIRLFNGPYGPYVNHGKVNASLSEGEAPETVTLETALQLLSSKESTKKGTAKSKGTKTSKAAIAASTTTSKSSKASGKTTKTTKTTSRKSSSSQSTTSKNS
(1073) DNA topoisomerase 1 [Roseiflexus sp. RS-1]
1
MGEKLVIVESPAKARTIQKYLGQGYRVEASMGHVRDLPKSDLGVDLDANFTPVYEVSPGKEKIIAALRKSIRQADAVYLATDPDREGEAIAWHITEAAKIPRGKPVYRVVFTEITPGAVRSAMASPRDIDRRLVDAQQARRVLDRLVGYKLSPLLWEKVRRGLSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQEARDPFRAVLIERAGRKLEKFDIGSGEQAQAIIVDLEGAAYIVRKVTRRDKRRSPPPPFTTSTLQQEAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARIVIRDRYGEAYLPPKPPVYKTKTKGAQEAHEAIRPTLSRRTPEQVQPYLTSDQYRLYELIWKRFVASQMEAAVFDSTTVDIGAGRGIERSAGNDPYTFRTTGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPLLAEGDVLALVQLLPVQHFTEPPPRFTEASLVKELERLGIGRPSTYAPTISTIIEREYVELADKKLVPTTLGRVVTDLLVQHFPSIVDYGFTSEMEQQLDDIAEGEKEWTPVLRSFYEPFEQKLADAQRSMRNVKREEILTDLTCPKCSQGQLAIRFGKNGEFLACNRYPECDFTSDFHRDGEGRIVIDAPAAPEVSDVICELCGRPMVLKKSRFGPFLGCSGYPECKNTRRLDKQGKPVPPPKATGVTCPKCRQGELLERRGKFGRPFFGCSRYPKCDYLVNSLEEVANYTPENNAPMEAKAEEQPATKRTKTSTGKKRAKTTAPGSGTPNVED
(1077) DNA topoisomerase 1 [Clostridium sticklandii DSM 519]
1
MGKNLVIVESPAKAKTIGKFLGKNYTVKASVGHIRDLPKSKLGVDVENDFEPQYITIRGKGSVVNELKKQAKKSDKVYLATDPDREGEAISWHLAYLLGLNEEEPIRIEFNEITKDAIKKAIKHPRKIDRPLVDAQQARRVVDRLVGYKISPILWAKIRKGLSAGRVQSVTTKLICDRENEINAFEPEEYWSIDAITQIDKKNKVDFKFYGDEKGKIELHSKDEVDLILKSIKNKDLVVKAVEKKERKRSAPKPFTTSSLQQEASGKLSFTTKKTMIVAQQLYEGVDIKGKGSLGLITYIRTDSFRISDEAQENAKNYINDKYGKDYFKKYQNNSKSKKKIQDAHECIRPSYVDLAPEDIEDSLSKEQFKLYKLIWERFIATMMADAIYDSQNISASIDKYIFKTNGSKLKFDGFMKVYSFSSQEETILPDMKEASVFPVKKIDPKQHFTQPPARYSEASLVKTLEELGIGRPSTYAPTISTILQRDYVEKKSNSLIPTELGFIVTEIMSENFKEIVDYTFTADMENNLDKIEDGEIEWQNIVKDFYSPLEESIEKAVENIEKVILEEKTDEICDICGSEMVIKFGRFGKFIACKNYPECKGTKPILERIGIKCPECSDGDVIIRKTKKGRIFYGCSSFPKCRFVSWDRPNGEKCPKCDSFLVLSKTKTTEKIKCSNKECDYEK
(1078) DNA topoisomerase 1 [Streptococcus gordonii str. Challis]
1
MYKLVTKTSKKSTTKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSTMSIDFENNYEPQYINIRGKGPLINDLRKEAKKAKQVFLASDPDREGEAISWHLAHILNLDEKEKNRVVFNEITKDAVKNAFKEPRQINMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEINAFKPEEYWTIDSTFKKGSRQFQASFYGINGRKMKLTNNDEVKEVLSLLKGDDFKVESVERKERRRNAPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAANYITDRFGAKYSKHGSKIKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMNVKIEQNGVQFTANGSQVKFDGYLAIYNDSDKNKMLPDMEKGDTVKRVNTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVKLVSKRFEPTELGEIVNSLIVEFFPGIVNVKFTAEMEAKLDDVEVGKEQWQKVIDEFYRPFEKEVAKAESEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVTCPQCQKGHVIERKTKRNRIFYGCNRYPDCDFTSWDKPVGRNCPKCDHYLVEKKVRGGGKQVVCSNGDYEEEKVK
(1079) DNA topoisomerase 1 [Mycoplasma hyorhinis GDL-1]
1
MSKLVIVESPNKIKTISKYLGEGYKVVASVGHVVNLKTSGSYGLGIDMQNWEPVYEVESNKKEIVKSLKEDVKNSDMVIIATDADREGEAIGHTLVEILKIENKYQRIKYNEITEAAILQSLKNPLKIDANLVNAQKSRRMIDRIIGFRLSSLLATKIKNTPITPSAGRVQSVALKLVIDREKEINDFIPYHYFTISAFYNKNTEIKYYNPENENPEWVAVKDIDKIYNSLKGKLKVVDKTIRSKKDAKITPLKQSALFKKAANYAASSVSSSLQRLYEGFGDQGLISYPRTDSTRLSQTFIDLAKSYIEEQFGKEYVSDSVKGFSGDQDAHEAIRPTDCSLTPELAKEKYDLKEIDFKLYQIIYNTTMQAIMSVPERQITRYEFLNQEHKFYLSGSIITFDGYFKLTKPDSENTNLPNWQINDEIEIEKYEKQAHHTNPPARYTDGSLIEKLDEIKVGRPSTFASSVKILQDRLYVEKQNKSLVPTNYGQITLEKLLQISPSIINANYTAQVEEELDEIAEGNLDYKKLMTNFWDNFQNVVQESMQNVEKTEIELEKVGENCPECNHELIYRNNKKTGARFIGCSNFPNCRFIKQDPNYKPKFRRFYKKAS
(1084) DNA topoisomerase 1 [Thermoanaerobacterium xylanolyticum LX-11]
1
MEKSLVIVESPSKAKTIHKYLGKNYKVEASMGHIRDLPKSQLGIDIEKNFEPKYITIRGKGPIIEKLKKEAKNASKIYLATDPDREGEAISWHLASLLNIDINEKCRIEFHEITKNAIQNAIKNPREINMNLVDAQQARRILDRLVGYNISPLLWKKIKRGLSAGRVQSVATRLICDREKEIEDFKPEEYWSISAYLYKEKKTQSFEAKFYGTKDGKVELKNENDVNEIVKDLTDDYVVENVKIGTKKRNPSPPFITSTMQQEASKTLGFTAKKTMMIAQQLYEGVEIKGEGSLGLITYMRTDSTRVSDEAKKAAYEYILQKYGKEYANPNATYAKKGGNIQDAHEAIRPTYIDLDPEKIKDSLKPDQYKLYKLIWSRFLASQMSPALYDTMNVDIINKNYVFKASGSKIKFSGFMAVYTDDDENENEDKMLPMLNSGDFLKLKELKPEQHFTQPPARYTEATLIKELEEKGIGRPSTYAPIISTLLERGYVIKEKKNLKPTELGFIVTDVMKEFFPDIVDVKFTAQMEEQLDRIEEGIEKWCDVIDEFYNGFNASLKIAEEQMKDIEIKDEETDIKCEFCGRNMVIKYGRYGKFLACPGFPECKNTKPLYEEIGVTCPKCGGKIIIKKSKKGKVYYACENSSNCGTMFWDRPISETCPKCGALLVEKHSKGRKIIKCSNCDYVK
(1085) DNA topoisomerase 1 [Dinoroseobacter shibae DFL 12 = DSM 16493]
1
MPVVVVESPAKAKTINKYLGSDFTVLASYGHVRDLPPKDGSVDPEHGFEMLWEIASDSRKHVKAIADALKDDDTLILATDPDREGEAISWHLQEALTKRKAIKKSTDVSRVVFNAITKSAVTEAMKNPRDVDMELVEAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVCLRLIVEREMEIEAFDPREYWSVRAVLETPRGQTYEARLTELAGKKLDKFDLATAEAAELAVQAVTSRKLSVTSVEAKPGTRNPSAPFMTSTLQQEASRKFGFGARQTMSTAQRLYEAGYITYMRTDGIDMAPEAVTMARDAIKERFGAAYLPDSPRIYKNKAKNAQEAHECIRPTEMSRAPEDLKVTEPDQRKLYDLIWKRTLASQMAAARLERTTVEIGSPDGQVALRATGQVVVFDGFMKVYTEGQDEESTAEDERRLPQIGQGDPAPLHKGGMEAAFAKAGSREDDVVEAAPTGGMQQGPGGLLSENGAVFGQQHFTQPPPRYTEATLVKRMEELGIGRPSTYASIVTTIQDRGYVTKDKNRLIPEDKGRLVTAFLVNYFRKYVGYDFTADLENQLDEVSAGDRNYKDVLDRFWRDFSAAIAETSELRITEVLEKINEVLAPHLFPPREDGKPPRLCPNCEIGQLSMRTARSGGAFIGCSNYPECRYTRPFGPPGMEEASGIPPEGKLLGEDGGDEIRVFKGRFGPYVQRGAVTEENKKPPRQSIPKSWVPEELELDKAVMLLSLPRQIGLHPDDGVPVWANIGRYGPYLKHADSTSDRGGTNANLEDIEEVWTVGMNRAVQLLAEKVASRGGRGAAAKPLRELGEHPEAGGPVNIMKGKYGPYVKWEKINATIPKETDPEQVTMEMAVQLIEERAAKSGKKAPAKKKAATKKKTAAKKTSAK
(1091) DNA topoisomerase 1 [Candidatus Nitrospira defluvii]
1
MAKSLIIVESPTKARTITKYLGRGYSVMASVGHVKDLPTSKLGVDLDNDFEPQYVTIKGKSKVLADIKKKAQEVDTVFLAPDPDREGEAIAWHIAQELHGKGKKKDGKVYRVLFNEITESAIKRALKSPGEIDMKLVQAQQARRVLDRIVGYQGSQLLWKKVRRGLSMGRVQSVAVRLICDREKEREAFRAEEYWSIVALLAGDNPPAFEAKLHSMNGQDADIGTGERAQQILDAVQGKSFVVQSIERKEKKRNPVAPFITSRLQQEAARKLHFSPKKTMTLAQQLYEGIEIGAEGPTGLITYMRTDSPRISQEATEDARVVIRERFGVEYLPATPNVYKTQKAAQEAHEAIRPTSAARDPESIRQYLEQDQYNLYKLIWNRFIASQMVPAIMDVTRVDSSPMGTPDRYVFRTTGTVVKFAGHTAVYLEGTDKELPSHKPKNEQETDDESDRQLPALREGESLHLVAQEAQTLPGLVSKQHFTQPPPRYNEALLIRELEEKGIGRPSTYASIISTIQDRKYVEKVEGRFLPTETGRTVNDFLLKGFPDLLDTEFTSHMEEQLDEVEEGTKPWVSAVRDFYTPFVREMELAQGIPGPKDIVEPPTNLPCEKCGRMLEIKWGRNGKFLACPAYKDDPPCKNTQNFEKLPDGTIKIVPKLEETTDEKCEKCSSPMVVKSGRFGKFLACSAYPECKTTKAIALGVKCPQPGCGGDLVQKRTKKGRNFYSCSRYPQCEYALWDRPINKPCPKCQAPFLVEKVSKQAGRSVQCRNEDECGYREAG
(1093) DNA topoisomerase 1 [Thermus thermophilus HB27]
1
MPKSAKRRASQPTGAETLVVVESPAKARSIQKMLGPGYEVRASLGHVVDLPERSLGVDVERDFAPTYEVKKDKKPVVEELKRAAEGKRLLIATDPDREGEAIGWHVARLLGRDPKEPLRVEFHEITPRVVRQAVEAPRPIDQNLVDAQQARRVLDRLLGYNLSPLLSLEFRKRALSAGRVQSVALRLVVEREEAIEAFRPEEYWVLRGVFAVEGGEAPLVATLHEVEGKRLWTGQGEKEGRLHLASEAEAHALAEALRKGSYRVAQVEVRERRKAPPPPFTTSTLQQAASSRLGYTAARTMRIAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEAVAAAREVIGKAFGPEYLPEAPRAYKNRREGVQDAHEAIRPTDPQRTPESVRPYLSEEEYRLYELIWRRFLASQMRDALYEQTAVTLADLEGRYAFRASGSVLRFEGYLRAWGRDAEEEEEPPVPAVPEGVPARLEEVLEERRFTEPPPRYTDASLVKTMEELGIGRPSTYAPTLETLEKRGYVARKGRTLFPTPLGRQVTAYLRERFPQVVAYEFTARMEERLDEVEEGRVPWPKVVWEFYEPFLGELAQVPKKTCPECGRPLELKVSRYGQFLGCTGYPECTYTEPLERREAEPIGEACPKCGRPLLRKEGRYGAFIACSGYPECDYTRDDGTPTGHTCPKCGGRVLEKRSRKGRPYYKCENNACDFLSFYPLLEEACPACGWPLVKKGEKALCLNPACPEHEPSLLPAPKEAKKGRSRGKGKPPLAPPKDWEELVPFLPGLSPEERRAVEALARGEALAEEEARLARRALFKLRMRKGKARKEPVRA
(1097) DNA topoisomerase 1 [Rickettsia felis URRWXCal2]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGEAISWHVAEVIKEKNKVKSDDFFKRVAFNEITKKAIIHAVENPRKLDANLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKDAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGDKYLPNSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVASLASENKEYLAKANGSTIAFDGFYKVYRESVDDEAEEENKMLPPLKEQEPLKTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVSLEKKRFMPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFSENKESKACPSCKTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENDGDLAATPNENKVLGTDKDGIEIYLKKGPYGPYVQLGEQEGKVKPKRSPVPASLNQNDITLEMALKLLSLPLKIGIHKDSGEEIMIGYGKFGPYIKYMGKFISIPKKYDFLNLSLDDAMKLIEDNKAKLEKKQA
(1098) DNA topoisomerase 1 [Thermodesulfatator indicus DSM 15286]
1
MKKGLIIVESPTKVRTIKKIVGKDFEVAASVGHIKDLPKSRLGVNVDNGFEPEYVTIRGKKEVIKKLKNAAKKAEEIYLGPDPDREGEAIAWHIAEELKSLKKPIKRLLLYELTEKGIKEALKNPGELDPNKFESQKARRILDRLVGYNLSPLLWEKVKRGLSAGRVQSVALRLICEREREREAFEPEEYWTIELLFETEEGPLCAKLKRYKGKAVKPKSETEAKAIVEDLLKQEFLVSKVEKKEVKRKPPAPFITSTLQQEAWRRLRFSAKKTMLLAQRLYEGIELGEEGAVGLITYMRTDSVRVAKEAQEEARAFIKQQFGPDFLPKKPHAFKSRKSAQEAHEAIRPTSLLRTPESLKPYLSREELALYDLIFRRFVASQMAEARFERTEIHIVGGDYELLASGQRLVHPGFLVLYRTDEEEEANLPQVEAGKSLKLKEIDPKQHFTQPPPRYTEASLIRTLEEKGIGRPSTYAQIVSTIKDRGYVETEKGYLKPTELGLLVNDLLVAHFPNIIETGFTARLEEALDEIEEGKKERVELLRSFYKTFEEVLRRAEDEMASLKAGVPSGIKCPACGEEMIIRVGRAGAFLACSRYPECKETRDYERNEKGVIKIVEKNRETGEVCEKCGRPMVIKRGRFGEFMACSGYPECKNTKPISTGIPCLKENCQGTLIKRRARTGKIYYRCSEKDCDFILWQEPIKEKCPECGAPFMVRKKERRKEYKVCPKCQYKEALDE
(1099) DNA topoisomerase 1 [Methylobacillus flagellatus KT]
1
MSKLLIVESPSKAKTLKKYLGKDFEVLASYGHVRDLVPKTGAVDPDHDFAMKYEVIDRNARHVDAIAKAVKTADAIYLATDPDREGEAISWHIAEILKSKKLLKDKLIKRVVFHEITKNAVQNAIEEPRDISMPLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWTIHLESAKHQHVFDAKLVQLEGKKVEQFTITNQAQQQEVVGKLLAVSAGKTTVSRVEKKQRSRSPAAPFTTSTLQQEAVRKLGFTTSRTMRVAQQLYEGIDIGSGTMGLITYMRTDSFSLATEAVMQIRDYIKQNFAAEYLPKSPIMYKTKAKNAQEAHEAIRPTDISRTPASMRAFLTDEQFRLYEMIWKRALACQMTQAKFDAVSIDLAVGSDANLFRATGQTLIFPGFIAVYMEGVDDEEEEGESKLPHLETGEVLAVQKIYGDQHFTEPPPRYSEASLVKALEEYGIGRPSTYASIISTLQDREYVVLDKKRFIPTDVGRVVNKFLTEHFTRYVDYGFTANLENELDDIAEGEREWIPVLNEFWQGFNNQIHEKSNVERPGVEMLDEACPKCGKPLQSRLGRFGKFIGCSGYPECDYIRNPNANANNNEPTVIGQEPESGKDILLLNGPYGPYLQIGLPEADSKKKPKRVSIPKEIPVSSLDMETALKLIALPRDLGQHPETGKKVVANIGRFGPYVNHDGKFKSIPKSESVFDIDLARAIELLAQANAGAAPIKELGNHPDGTGNIAIYAGRFGPYVQHGKLRATLPKGQEPETLTMEQALELLSAKAAKDAPAKKAKTTTAKKTSSTKKAATTTRRKKASAGESE
(1100) DNA topoisomerase 1 [Lactobacillus ruminis ATCC 27782]
1
MESPSKAKTIEKYLGNRYKVMASLGHIRDLPKSKMGIDVENNYEPHYISIRGKGDVIKELRKEAKKADHVYLAADPDREGEAIAWHLSYLLGLDPKDKNRVVFNEITKDAVKNAFKTPRAIDMNLVDAQQARRALDRLVGYSISPLLWSKIKKGLSAGRVQSIALNLIIKREKEIRNFKPEEYWTIDAEFKKGRSKFEGSFYGIDGKKTALQNNDAVKSVMERIDTKKPFTVDNVEKKERKRQPPLPFTTSTMQQVANNNLKFRTQKTMMVAQQLYEGINIGRSGTVGLITYMRTDSTRISEVAKHEASEFIHSEYGENYAAIKPRQGKLAEGAQDAHEAIRPSSVLRTPKSLEKYLDKDQMKLYSLIWSRFVASQMTPAVIDTMRVDLEQNGVSYRSTGSKLKFDGFTKVYADSKHKDNMLPDLENGDEVIMSRNQPNQHFTLPPARFTEAALIKTLEENGVGRPSTYAPTLNTIQKRYYVKLAARKFEPTELGEIVDNMIGKCFPDILNVKFTAKLEDQLDEIEEGKQEWVKVVDEFYKPFSTEVKTAEEKMAKVKIKDEPAGFDCEICGAPMVVKMGRFGKFYACSRFPDCRNTKAIVKQIGVKCPQCKRGEIIERKSKKNRLFYGCNRYPECDFISWDKPIARDCPKCGHFLIEKKTKQGMQVKCPNNDYEEAIQK
(1101) DNA topoisomerase 1 [Runella slithyformis DSM 19594]
1
MSKNLVIVESPAKAKTIEGYLGADFTVKSSFGHVRDLPDKDLGVDVKNGYLPAYEVSADKTKVINELKKLAKSSDEVWLATDDDREGEAISWHLKEALGLPKDTKRIVFREITKTALQKAIQNPRAIDMDLVNAQQARRVLDRLVGYELSPVLWRKIKIGNNTALSAGRVQSVAVRLIVDREREVEAHESKSSFKVIARFTLEGGKVLEAELPKNFENEAQARTFLEKCIGAAFKIKNLEVKPGKKSPAPPFTTSTLQQEASRKLSFSVSQTMTVAQKLYEAGKISYMRTDSTNLSEEALQKAKDQIVTEYGDKYHHHRVFKTKSESAQEAHEAIRPTNFGELKASSDRNEQRLYELIWKRSIASQMADAQLERTIATITISTTSEELVAQGEVIKFDGFLKVYLESKDDEEEDTKGMLPPLNIGQVLALDILKATEKFSRPKPRYTEASLVKQLEEMGIGRPSTYAPTLSTIIKREYVVKQDKKGQEREYKELTLKQNEIKEVKGKETYGAEKAKLFPTNTGMVVNDFLVELFPDVVDFSFTASVEKEFDEIAEGKLSWQQMIDGFYRGFHQKIGEVGESKVLKKTEARELGIDPKSGKPIFAKIGKFGPYVQVGEATEDAKPQYANLKKGQLVETITLEEAIELFSLPREVGFFEDKPMVVGVGKYGPYVKHDDKFYSLDRGDDPYTIEAEACIAAIRLKRGDLAGEGEGLGFLEEKPITTGMGKYGPFIKHDDKYYSLPKGMSLQRVTREEALEIIQKKREAESNKVIREFPENTTVKVLRGPYGPYIAVGKRNIKIPKDTDPASLTLEDCLKLAGG
(1102) DNA topoisomerase 1 [Pedobacter saltans DSM 12145]
1
MAKNLLIVESPAKAKTIEGYLGKDFLVKSSYGHIRDLRKDDGAIEVDNNFKQHYEIPADKKQVVAELKKLAKSAETVWLASDEDREGEAIAWHLYESLGLKENQTKRIVFHEITKPAITKAIENPRTIDYNLVNAQQARRVLDRLVGFELSPVLWKKVKPSLSAGRVQSVAVRLIVEREREINLFNAESAYKIIAIFSTGKGKEIFKAELSQRYAEQKEAEKFLEDCKSALYKINDLDIRPTKRTPAPPFTTSTLQQEAGRKLGFSVSRTMSIAQRLYETGKITYMRTDSVNLSETALNASEIEINSAYGSKYHHKRIFKTKSAGAQEAHEAIRPTHFEWHTIEGDASEKRLYELIWKRAIASQMSEAQFEKTTARIGISTRKEELVANGEVLKFDGFLKVYLESEDEESDSHLDDKTDNGILPPLNIGQELILNEMTALERFTRPAARYSEASLVKKLEELGIGRPSTYAPTISTIQNRGYVVKEDRDGRSRTYKTFTLKDGEVKSIVKSEITGTEKGKLFPTDIGAVVNDFLVEHFKGIVDYNFTATVEKQFDEIANGLKEWTDMLKKFYQPFHSEVEDTLKNADRATGERLLGLDPESGKNVYTKVGRFGPMVQIGEMDEEDKPRYASLLKSQSVETISLEEALNLFQLPFQLSDYKDKEVSVGVGRFGPYVKWGDTFISLPKNEDPLTVTNERAIEIIEEKISIDAPVAEYQGHPVSKGKGRFGPFLKWKDLFINVPVRYNFDKLSQSDINELISAKIEKEANRYIQQWETEKIAIENGRWGPFIRFGKQMLKLGKNPTTGQKYTAEELSTVSLEDVKKLIVEQVPDAFDAKAKKTGRKTTKK
(1103) DNA topoisomerase 1 [Staphylococcus haemolyticus JCSC1435]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDVEDNYEPKYITIRGKGPVVKDLKKYAKKAKNVFLASDPDREGEAIAWHLSKILELDDSKENRVVFNEITKDAVKESFKHPRGIEMDLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKSKFTAKFLHYKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISQTAKDEAKQYIEDKYGKDYLSNRTAKGKQGDQDAHEAIRPTSTLRTPYEMKAYLTRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNNIKFRANGQTIKFKGFMTLYVEAKDDKDNEKENKLPNLSKGDEVTATQIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVYEQVKDYFPEIIDVEFTVNMETLLDKIAEGDIGWRKVIDNFYGSFKLDVERAEEEMEKVEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPKCKDGDVVERKSKKNRLFYGCSNYPECDFISWDKPVGRDCPKCNHYLMEHKKGRSSQVICSNCDYKEEVQK
(1106) DNA topoisomerase 1 [Thermotoga neapolitana DSM 4359]
1
MSKKKKYIIVESPAKAKTIKGILGPEYEVFASMGHIVDLPKSKFGVDLKNDFEPQFTVIKGKEKIVEKIKAISKVGEIFIASDMDREGEAIAWHVARLTNTLGKRNRIIFSEITPRVIKEAVKNPRKIDMNKVHAQLARRILDRIVGYSLSPVLWKNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRVVVKFHGLEAEMITKEKTFLEEDVLKELQSIEELVVEEKTVSRKKFSPPDPFKTSSLQQEAYAKLGFSVAKTMLLAQQLYEGVETKEGHIAFITYMRTDSTRVSDYAKEAARELIEKDFGKEYIGTGRRKKSRTARIQDAHEAIRPTDVFMTPEKISKYLNPDQRKLYELIWKRFFASQMKPSEYEETRFVLRSKDGKYRFKGSILKRIFDGYERVWKTERNVGDFPFEEGEIVKPVEVEIKELETKPKPRYTEGTLVKEMERLGIGRPSTYASTIKLLLSRKYVKKIRGYLYPTVIGSVVMDYLEKKYADIVDISFTAEMEKELDEVEQGKKTDKVVLQDFYRTFSKVFNENDRIIINYPTDQKCSCGKDMVLSFGRYGFYLKCECGKSRSVRNDEVAVIENGKMFIGRKNDEDSTSDGGNVKRKRSLTEKRRKGKKSS
(1107) Uncharacterized protein [Lactobacillus reuteri SD2112]
1
MATKTTKSTAKKTTRRRSKIKKNLVIVESPSKAKTIGKFLGRSYKVVASLGHIRDLPKKPDGGRY
(1111) DNA topoisomerase 1 [Hyphomonas neptunium ATCC 15444]
1
MKLVVVESPAKAKTINKYLGKDYKVLASYGHIRDLPSKNGSVDPENDFEMVWEADSKSAKRISDIANALKDADTLILATDPDREGEAISWHLVEALRKRRALKKDVAIERVVFNAITKSAVTQAMEHPRAIDAELVDAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRIVCDRENEIESFRAQEYWNIVAELRAPDGTAFEARLHSLDGETLKKFTLGNQGDANRALEIVKVGGYSVVSVEAKPVKRNPPPPFITSTLQQEASRKLGFNAKRTMQAAQKLYEEGRITYMRTDGVNMAEEAYVAARTMIQSNYGARYLPENTRRYSSKAKNAQEAHEAIRPTDFNLRPEDYHGDGDLKKLYTLVWRRAVASQMETALFERTTIDLASKDKRAGLRATGQVLVFDGFIKLYTEGHDAGDDDDDAEGRLPKMAEGQHADLLKADANQSFTQPPPRYTEASLVKRLEELGIGRPSTYASTMSTLEDRGYVRIEGKALVPEDKGRLVTAFLENFFSRYVEYDFTAGLEEKLDVISDGKLDWKAFLREFWQQFAADIDGTKDLRVSAVLDALNEALGAYVFPRQDAEGNPIENPRQCPLCKEGELSMKLGKFGAFVGCSRHPECKYTRQFSSEGGDAAINPDGNEIGIHPDTGAMILLKSGRFGPYVEMANGEKPKRASLAKADNAAELTLERAVELLSLPREVGPHPEDGEMILANFGRFGPYVQHGKTYANLKDPRDVFTIGVNHAVSLIEDKKARGSARGGAAALKALGDHPDGGAIEVFEGRYGPYVKWGKVNATLPKEITPDVVTLEQAIELVNAKGGSAKKKAPAKKAAAKKPAAKKAAPKKKAPAKKAEE
(1113) DNA topoisomerase 1 [Wolinella succinogenes DSM 1740]
1
MKNLIIVESPTKAKTIKNFLGKEYEVIASKGHIRDLPKHNFGIKIEGQSFLPDYKIEKGHEAVVKEIKALAQKAKTIYIATDEDREGEAIGYHISHAIDKDPTTLPRIVFHEITQNAIKHALETPRSINMDMVNAQQARRLLDRIVGYRLSPLISSKIQKGLSAGRVQSSALKLIVDREREIRSFVPVTYFTIEALFEKGIEAELIEFEGEKLEKLSIGESKKANEMVKVLQKESWSITGIEHKRRKTSTPPPFMTSTLQQSASSVLGFSPSKTMMAAQKLYEGVMTHQGVMGVITYMRTDSLNIAKEAQEAARSRIKEVYGERYLPKEPKVYTTKSKSAQEAHEAIRPTLIDFTPQLAAQYLKGDELKLYSLIYNRFLASQMNDAEFELQTILLGSSKGVFKVSGRKLIFDGFYRVMGSEDKDKLLPELQKGEALKLEECKANRHETEPPARFSEASIIKTLEALGIGRPSTYAPTISLLAGRDYIRIEKKQIIPEEVAFKVIEVLEAHFTEIVDSHFTATLEEELDEIAESKKDWQKVLWDFYEKFDAKIALGKKNIESQKVAIPTGEMCPKCGAELVRRMSRYGEFVACSGYPKCKYIKPQESSPEQEGEESEEVCEKCGKPMVKKRGRNGEFLACSGYPDCKNTKSLKKSSTPKKVLEVKCPKCGGEIIERSSRRGNFFGCANYPKCDFISSHEPINEKCQKCGGMMAKRTYRKKEVHECIACKDRIEVEERNEEEK
(1115) DNA topoisomerase 1 [Polymorphum gilvum SL003B-26A1]
1
MESPAKAKTINKYLGSGYQVLASYGHVRDLPAKDGSVKPDEDFAMSWEVDSKSQKRLNEIAAAVKDADRLILATDPDREGEAISWHVLEVLHKKRVLKDKPVERVVFNAITKQAILEAMKHPRAIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLICDREMEIETFVKEEYWSILANLKTPSAEVLQAGLTGFDGRKIGRLDIKTGDEAETIRRMLEAARYTVASVVSKPAKRHPQPPFTTSTLQQEASRKLGFAAARTMQVAQKLYEGVAIGGETTGLITYMRTDGVQIAGEAISATRKVIGQDFGDNYVPEKPRFYSSKAKNAQEAHEAIRPTDLARRPRDVARFLDPDQARLYELIWKRTMASQMESAVLERTTIDIDAAGAGKTATLRATGSVVRFDGFLALYQEGRDDEEDEAARRLPAVDDGAPLALAAVEGKPSAIEADQHFTTPPPRYTEASLVKKMEELGIGRPSTYASTLQTLRDRDYVAFDKKQLVPQDKGRIVTAFLESFFNRYVEYDFTASLEEQLDRISAGELSWREVLANFWRDFSASVDETKDLRVSQVIDALNDLLAAHIFPPREDGKDPRACPTCATGQLSLKVSRFGAFIGCSNYPECSYTRQLARNGDGEGEDAASDGPKVLGTDPATGLEVSLRSGRFGPYVQLGEDAKPRRSSLPRGWSAADLDLARALQLLSLPRDVGAHPEDGKMITAGLGRYGPFVQHDGTYANLGSADEVFSVGLNRAVDLLAEKRSKTGRGRATPAALKELGEHPSAGGPITVRDGRYGPYVNWAKVNATLPKGSDPMAVTLEQAVELIAAKGGGKAAPKKAATKKPAAKKPAAAKKSASRTKAKAGGAAADGTS
(1118) DNA topoisomerase 1 [Chlamydophila caviae GPIC]
1
MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKEFGIDIDHDFEPDYQVLPDKQEVISQIRKLASSCDVVYLSPDPDREGEAIAWHIANQLPKNTHMQRISFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIRVFLQDPKTSKTFWAHLYSADGKKWEKELPKGKTEDEILLINSEAKAQHYVELLEDASYRVTRVEAKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNNVRDYIQDTFGQDYLPKSPNLYATKKMTQDAHEAIRPTDIQLSPDKLQGKLTDDQFKLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKIDDDVAEEENLSLPQLHAQDVLDKERVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVVTDIECSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVDTPWDSPCPVCAGKMKVRHGRFGTFLGCLNYPECRGTISIHKKGEEVEKEESIPCPAIGCSGKILKKRSRYNKTFYSCSEYPDCSVIGNTIDAVVTKYTGTTKTPYEKKTTGKKKSASKSRKTTKTPAKKKKSEGKTTKTTRVGALLTPSPELALMIGDEPVARGEATKKVWKYIKDHNLQSPENKKMLVPDDKFQAIIGPEPVDMFQLPKLLNQHLFKAG
(1124) DNA topoisomerase 1 [Acidithiobacillus ferrooxidans ATCC 23270]
1
MTKLLIVESPTKAHHIQAMLGSGWSVKATVGHIRDLPIKGDAAYVRPPDFKLNYEITERASKTVPALRAAARDAESVYIATDPDREGEAIAWHVCQVLGIKPGAAKRVTYQEVTEPAIRKAIAAPRTVNMPLVAAQEARRALDRIVGWEVSGPLSNAIGSRASAGRVQTPALSLVVAREQAIRQFKPTPWFQVLAHVAGKDAAPDWRAVWVDGTQEGEYFQDKAHAKALADALPSMALKVTKAETKPVRKPPAPPFTTSSMQMDGARALKAPVDAIMKAAQSLFEHGHITYHRTDSPNLSEEGEGLLRAALKKENLPLVETPRRWRSKGGAQEAHEAIRPTRPMVRQAGENDLEQALYDLIRKRALASQMPDAVYQQTSCTLDGGMFQGRPAVFRAVGSVLKDPGWMALYRETAEDEEGTENPAANPVPRLAVGDAVRAARGECLSKTTKAPPRYTESTLIKALEDHGVGRPSTYASILKNLFAREYIRRKGKSPALYATELGEKIVEALSVFDFSNVDYTREVEADLDRITEGQMRPRDLLAKSFADIQRILDAMPTQARAQGRPCPIEGCDGTVRRLESKRKPGVFFWMCSNRDAHPLLQDNDGEPGAPFAERVEAGDGPACPECGAATSRQETGKGYGYFRCGKGHGSWWDDKGSLGKKWEDRAPAQGAASGPARKNTGSKASSTKRPTKGTRTKARSSIMD
(1134) DNA topoisomerase 1 [Ruminococcus champanellensis 18P13 = JCM 17042]
1
MSNLVIVESPAKAKTIQKYLGGDYDVIASMGHVRDLPKSKFGVDVEHDFAPQYMDMKGKEDVIKDLKKHAKKADKIYLATDPDREGEAISWHLAQMLNLNMEDNNRVAFNEITQAGVRNGMSHPHKIDVDLVNAQQARRILDRIVGYQLSPFLWKKVKRGLSAGRVQSVAVRLVVDRENEIRAFKTQEYWSIDAKLTAPSSRKVFAAKLATIDGQKAELATKEQTDGILQTLEQAQFTVAGVKKRVTNKQPAPPFITSTLQQDASRRLGFQAKRTMKAAQELYEGVEIEGMGAVGLITYMRTDSLRISDEAKAAAAAYIEQTYGKQYLPPTPRVFKSKKNAQDAHEAIRPSMPDLTPERVKNSLTTDQFKLYKLIWERFIASQMANAQLNTVSADITAGNCGFKASGYSVKFEGFTVLYEESKDADAEDNKVLPPLEQGDLLKVKSLDGNQHFTQPPARYSEATLIKALEENGIGRPSTYAPTITTILSRLYVERDGKQLRPTALGEVITELMKEHFKHIVDAKFTAKMETDLDRVEHGDCDWVSMLHGFYDDFEKTLSKAEVAMEGKRVKVPDEETDVVCELCGKKMVIKIGRFGKFLACPGFPECRNTKKIVQETKGTCPLCGKKIVLKKSKKGRSFYGCDNYPNCNFMTWSTPVEDTCPKCGCTLFKKGGRSGKLVCEKPGCGFERSLKE
(1135) DNA topoisomerase 1 [Sphaerobacter thermophilus DSM 20745]
1
MAEEAKRKRTTTSTEDEQTTATRRTTRRTAAKSDGTTSTRSRATKSTRTTKTTKQASGNGTLVIVESPAKARNIGRILGRGYTVKASMGHVRDLPKSKLGVETDRDFAPVYLIPRDKSKVVKELRADVKEAREILLATDPDREGEAIAWHLVEATDPGDKPVRRIVFHEITPEAIREALRNPRGIDMRLVEAQQARRILDRLVGYEISPLLWRKVKRGLSAGRVQSVALRLVVEREREIQNFVPQEYWTLDAELAKREAVNGRKPKPFVASLSRVNGQKPDLKDEASTMAIVRALDGAEFQVVKVEVKETQRRPAPPFTTSTLQQEASRKLNMPVRRTMQIAQELYEGIDLGDAGTVGLITYMRTDSTNVAASAQARAREVIAERYGPEFLPDRPPVYTRKAKGAQEAHEAIRPTDPARDPESIKAFLGGASSPRYKLYRLIWQRFIASQTRNAVFDSTAVDIDAGPPGGPKPYRFRATGSVIKFPGFLAIYREGRDDDTVDEIDREALPPLTEGEVLDLVRLLPEQHFTQPPPRFTEATLVKALEELGIGRPSTYAPTIATLQARNYVTVEQRRLYPTELGTVVNDLLVQHFPDIVDVNFTSKLEDELDQIASGEQSWVPMVRAFYGPFHETVERAEKEIGRVKVADEPTDEVCEKCGRPMVIKLGRYGRFLACSGFPECRNARPLLQKIGVTCPQCGEGDIVQRRTKKGRVFYGCSRYPDCNFSSWEKPTGEPCPQCGGVLVETRGGTVRCSTQGCQYRATRLERTA
(1137) DNA topoisomerase 1 [Bacillus halodurans C-125]
1
MADYLVIVESPAKAKTIGKYLGKKYTVKASMGHVRDLPKSQMGVDIEDEYSPRYITIRGKGPVLKELKSAAKKVKRVYLAADPDREGEAIAWHLAHSLDIDETSECRVVFNEITKQAIKDAFKSPRPINMDLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIDREKEIQAFEPEEYWSIQGTFALDGEPFEAKFYGTNGKKVELKSEDDVNNVLAKLKGDQFHVDSVQKKERKRNPVSPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKAETKEYIESKFGKEYAQNGTKAVKKDKKSQDAHEAIRPTSVERDPKSLKEYLSRDQLRLYKLIWERLVASQMAPAIMDTMTVDLSNEGVLFRATGSKVKFPGFMKVYIEGNDEGKKEEDRLLPNLQEGQTVTKEEIEPSQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQKRGYVALDERRFVPTELGEIVLELMTEFFPEILDVEFTAKMEDDLDSIEEGKQQWIKIIDDFYKGFEERLKVAEEEMKEVEIKDEPTGEMCEKCGHEMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPKCEKGEIVERKSKKRRVFYGCNQYPECDFVSWDKPIARSCPKCSSYLVEKRTKKQVQVQCSSCDYKEEAN
(1139) DNA topoisomerase 1 [[Eubacterium] cylindroides T2-87]
1
MKKNLVIVESPSKSKTIEKYLGKDYKVVSSKGHICDLATSGKEGLGIDVDHDFEPTYKISKEKKDVVKELKELTKKAKDVYLASDPDREGEAIAWHLARVLDLDIDTTKRIVFHEVTKPAILEAMEHPKHIDMDLVRSQETRRMLDRIIGFKLSKLLQNKIRSKSAGRVQSVALKLIVERENEIKSFKSEEYWSVHANLKKGTQSFEATLSKVDGKKPKLKNEQQASEIVERSKGDFIATSITKRSKKKQPKLPFTTSTMQQEASTKLGFGARKTMSIAQKMYEGIDLGGQMQGLITYMRSDSTRLSDLFVKDTLAYIQDEYGKEYVGKAHTKNKANTQDAHEAIRPTDIKNTPESIKQYLTNDQYRLYSLIYARTLASLMKEASFNVTTITFEVDGLQYSASGQTMAFDGYTKVYKKYEKQTDELLPEIEENEVFHDVVVEPKQHFTEPPARYTEARLIKELEEKSIGRPSTYATIIDTLQKRGYATLEKTSETSKTKVFVPTKQGMLTDEKLGQYFSDVINVEYTADMEKTLDEIAEGKQDSIAYMHQFYDKFAPIVEDAYSKMPKMELEKVGRTCPSCGGDLVYRNGRYGKFISCINFPSCRYTENDEAEQENADPNQEEKICPNCGSKMIIKKGRYGPFWACSNYPECKTIQPLKEKAKPEPTGEMCPECGHELVKRKSRYGTTFIGCSNYPKCRYIKKEPKEKK
(1140) DNA topoisomerase 1 [Candidatus Cloacimonas acidaminovorans str. Evry]
1
MSKGLIIVESPAKAGTISKFLKNQFSVKASMGHIRDLPKRELGVNVHQGFKPVYIIDKTKSKVIAELKEATLSADSVYLASDNDREGEAIAWHLSETLKKELNNKPVYRIVFNEITSQAINEAIKNPGQIDMAKVEAQQARRILDRLVGYEISPLLWKVITKDLSAGRVQSVALRLICEREAEIKAFVPKEYWKIEADFWKDNLPPFKAVLEKIEGKKVEIPDEKSAIEIVENSQNAEAILSEIKRSNRNVEPLPPFITSTLQQEASKILGFQAQKTMSIAQVLYEGIDLGGERTGLITYMRTDSTRMAEEAITKAQNLIKERFGKELVHPKVRVFKNKQSAQDAHEAIRPTDPFRTPESVAQYLTKEQMKLYTLIWQRFIATQMIPVKLLSTSVKINAGKAEFVSSGAQIMEEGFLKAYPHLYIPLGEKIHQDYAKNDVLEHSPLEKTQHFTTSPARYTEASLIKELEAKGIGRPSTYATIIETLRKRKYVTMEKKAFLPTQLGSDVNRFLVDKFDYLFNVQFTAEMETKLDEVEYSNIAWNEVVQEYYDQLVALIRQVDVKKEKNNFVQDTGIVCDVCKQGTMLIKHSKRGDFLSCSRFPQCKNTKNFTRDEDGNIKIFVPTPLNENCPQCGSPLMLRTGKYGEFIACSNYPKCKYARPKTLGIKCPECGIGELTARKSKKGRTFYSCNRYPECKYITNDKPLPISCPKCGNPYIVEKYSREKGKIKICPNCKTEME
(1141) DNA topoisomerase 1 [Thermotoga naphthophila RKU-10]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKNKFGVDLEKDFEPEFVVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGKKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKTNLSAGRVQSATLKLVCDREREILRFVPKKYHKITVKFDGLTAEIDVKEKKFFDSETLKEIKSIDELVVEEKEVSLKNFSPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKDEARNLITEVFGEDYVGAKGAKRKGNTKIQDAHEAIRPTNVFMTPEEAGKYLNPDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWTTERNTGEFPFEEGESVKPVVVEIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTVVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLQEFYQSFSSVFDRNDRIVIDFPTNQKCSCGKEMRLSFGKYGFYLKCECGSTRSVRNDEIAVIDDGKIFLGRKDSESGSPDGRSIKGKRNLPEKRRKG
(1142) DNA topoisomerase 1 [Agrobacterium radiobacter K84]
1
MMNVVVVESPAKAKTINKYLGPGYTVLASFGHVRDLPAKDGSVLPDQDFEMLWEVDPASQKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLNKKRVINGKPVKRVVFNAITKKAVLDAMADPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFISEEYWNLSAILKTPRGDEFEARLVAANGKRLQPRAIGNGEEAGNLKALLEGASYVVDTVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIDAARTAIADQFGNRYLPEKARLYSTKAKNAQEAHEAIRPTDFDRTPDRVRKYLDADQLRLYDLVWKRGIASQMASAEIERTTVEILADNGGQKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDADDEDGRLPEINARENLAKQKINSTQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLATLRDRDYVTIDKRKLLPQAKGRLVTAFLESFFTKYVEYDFTADLEEKLDRISAGELNWKDVLRDFWRDFFAQIEDTKELRVTNVLDALNEALAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNYTRQLSSEGGTEAEASGLNEPKALGTDPVTNEELTLRSGRFGPYIQRGDGKEAKRASLPKGWKPEDIDYEKAMALISLPRDIGKHPESGKMISSGIGRYGPFLLHDGSYANLETVEDVFTVGLNRAVTVLAEKQSKAGGGRGTPAALKDLGAHPDGGGSITVRDGKYGPYVNWGKVNATLPKGSDPQAITVEEALALIVAKAGKSGGGKPARAPAKAKTKTAAAASKTTKTTAKPKAKAATKAKTTKKSAE
(1144) DNA topoisomerase 1 [Anaeromyxobacter sp. Fw109-5]
1
MPRATKAAAAAEGVKAEGVKKEKAAPPKRAAKKVAQGGSLVIVESPAKAKTIKKYLGRSYDVRASVGHVKDLPKSKIGVDVEAGFTPQYDVIKGKAKVLSEIKRAARSAERVYLATDPDREGEAIAFHIAEELGDSGDGRVRRVLFNEITKNAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFKPEEYWTLEAELAAKLPPEFRARLSKVDGQKAELKEGAVTHALVKDLDGATYVVATVDKKERRRNAPPPFTTAKLQQEAANRLGFTAKKTMTLAQKLYEGVELGDEGAVGLITYMRTDSVRLSTEAVDAARGYIAEAYGQDHLPEAPNVYKTKAKAAQEAHEAVRPTSLEWTPARVAPFFEQIGERDMYRLYELIWNRFVACQMVPAVYDQTTADITAGRATFRATGSILKFPGYLAVYGAKPPEDEAGAEEEAKENGDREKANEERQLPPLEAGMILDLRRLLPEQHFTQPPPRFNESSLVKELEQRGIGRPSTYAAILENIQEKGYVEKVERNFKPTHLGLVVTDELVKSFPREMDLAFTAGMEERLDEIEEGNAAWQQVLKDFYDSFKDDLAKAEVNMRDVKRQEIATELTCEKCGKPMVIKWGRMGEFLACSGYPECRNTMNFKRGEDGTIVPEKEEDVPTDEKCPECGAAMVMKRGRFGRFLACTRYPECKGTKPVSIGVSCPKGCGGYISEKRSRRGKTFYGCSSYPGCDFVSWDRPRNEACPQCGSAYLLDKYSKKTGPYVACPNKECGYRRDAEAKAPGAASEA
(1146) DNA topoisomerase 1 [Rhodomicrobium vannielii ATCC 17100]
1
MNIVIVESAAKAKTINKYLGADYKVIASYGHVRDLPAKDGSVLPDNDFEMTWEVEADSNRIVNEIAKAVKGADRLILATDPDREGEAISWHLLKILEQKRALNGVSVERVAFNAVTKDAILTAMKNPRKIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVVDREAEIEAFRTREYWTVEAALKNGGGDAFTARLVARAGKKLDKFDIPNEALAHAYRDAIKGQSYRVDSVDAKDHKRNPAPPFTTSSLQQEASRKLGLSPRQTMQIAQKLYEGIDIGGETVGLITYMRTDGVQIVGEAIAQARGQIESQFGARYVPSAPRIYKTKAKNAQEAHEAIRPTDFGRQPDKLRGLSAEEARLYKLIWQRAVASQMASADIERTTAEISVPGKDGVPYGVRATGSVVKFDGFMRLYEEGRDDTDDEDSARLPPLKQGEALKDSGVTAAQHFTEPPPRYTEATLIREMERLGIGRPSTYASTMAVLREREYVKLEKKRLVPEDKGRLVTTFLEAFFKRYVEYDFTAYLEDRLDQISDGKLDWKALLREFWQDFIGAVTDIKDLRVTQVLDALNELLGPHIFPAKEDGGDPRLCPLCNQGQLSLKIGKFGAFVGCSNYPECRYTRQLKTGENGNGDGAAPAGDTVLGNDPETGLAVCLKNGRFGPYIQLGEGGDGEKPKRASIPGGMGLADVDFAYALKLLALPREVGPHPETQKTIMAGFGRYGPYVEHDGKYVKIDAEEVFTIGLNRAVTVIAEGGTGGKGRAPKTEPIKVLGEHPEKGGKMEVLAGRFGPYIKWGKVNATIPKGTEPQDVTVDEAVRLIAARIEAGDGKKGRGKPTKSAKAPAKEKKPAKAKTADAGDEAEAPKKAKTAAPKKAAANGKAKSSAKEKSAKADEADKKPKAKASAKKTTSKAAGGTT
(1148) DNA topoisomerase 1 [Caldicellulosiruptor saccharolyticus DSM 8903]
1
MKKLVIVESPAKARTIAKFLGKEFKVEASMGHIRDLPKSDLGVDVENNFAPKYINIRGKADVINRLKKSAQEAEKVYLATDPDREGEAISWHLAIILGLDQNDKVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIEKFKPEEYWTLEAVFKKDNQEFKAKFYGSKKGKLELKNQEQVDKIINQIKDKNFKVTKLKISEKKKNPPPPFITSTLQQEASRKLRFTPAKTMMIAQMLYEGVEIKGEGSVGLITYMRTDSTRVAEEAQEAARRIILQRFGKEYVPEKPRVYKTKKDAQDAHEAIRPTYIEKDPESIKDSLTPDQYRLYKLIYDRFLASQMESSIYDSLSAELEVEGYVFKLTGSKLKFAGFMEVYVEGKDTDEEEEENQLPEIFEGEMLKPIKLEKKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKVVTNILKEYFKDIIDIEFTAELEENLDRIEEGKADWVEIVRKFYLPLEKELETARNTMQQIKVDDEETDVVCENCGRKMVIKKGRYGRFLACPGYPECKNTKPYFDYLDVLCPKCGKKLIEKKSKKGKKYFTCESYPECNFIVWERPAKNCPKCNQLMFEKGKKRSKKLVCSNESCGYEEKIVEKGE
(1149) DNA topoisomerase 1 [Xanthobacter autotrophicus Py2]
1
MQVVIVESPAKAKTINKYLGPGYEVIASYGHVRDLPSKDGSVDPDADFRMLWEVDPKAQKRLNEIATAVKGADGLILATDPDREGEAISWHVLEVLKQKKALKDQKVERVVFNAITKQAVLDAMKAPRAIDVALVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIETFVQKEYWSILARLATPRAEEFEARLTGADGKKITRLSVGTAEEAKAFRAALEAADFRVRSVEAKPMRRHPQPPFTTSTLQQEASRKLGLAPARTMQIAQRLYEGVDVGGETVGLITYMRTDGVDMAPEAVAATRSAIGKQFGPKYLPGVPRKYTTKAKNAQEAHEAIRPTDPSRHPREVARHLDGEQAKLYELIWIRTVASQMESAELERTTADIEAKAGGRTLDLTATGTVVKFDGFLTLYREGKDDEDDDEESRRLPAMSANEKLNRRDILTTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLAVLRDREYVKLEKKRLVPEDKGRLVTAFLESFFKRYVEYDFTADLEEKLDEVSAAELDWKEVLRAFWQDFHTAVEATKDLRVSQVLDALDEMLTAHIFPPTQDGSDPRLCPTCGNGRLSLKMGKFGAFIGCSNYPECRHTRPLTGDGAPEGDGKRELGIDPESGEDVTIRAGRFGTYLQLGEGKDGEKPKRSSLPKGLAPADVDLETALKLLALPREVGKHPEDGEPILAGIGRYGPYVQHGRTYANIEDGDDILAIGLNRAVVLIAEKQSKGRGGRGAATPGRTLGDHPTLGGPVTVRPGRFGPYVNHGKVNATLPKSVDPEALTLAEAVTLIDAKAALSPSKAKAPRKAATKAAASGEDAPAKAATKTAAKKPAAKSAAKKTATKQPAAKKTTKTASKGPKAAE
(1150) DNA topoisomerase 1 [Lactobacillus sakei subsp. sakei 23K]
1
MAGKNLVIVESPAKAKTIEKYLGRNYKVVASKGHIRDLPKSQMGVDFENNYEPKYISIRGKGETIKELKKHAKKADHIYLAADPDREGEAIAWHVSHILKLDPTDKNRVVFNEITKDTVKSAFKNPRSIDMKLVDAQQARRVLDRIVGYSISPLLWQKVKKGLSAGRVQSVALKLVIDREQEIKAFKPEEYWSLDAEFKKGRSKFKASFYGLNGKKTALGNNDAVQDVLKQIDKTQPFTIEDVKKRERKRFAAAPFTTSSLQQEANRKLNFRTRKTMMQAQQLYEGINLGGKEGTVGLITYMRTDSTRISTGAKHEASQFIHDNYGEEYAAVKAHKTKNPEGAQDAHEAIRPTSVMRTPKSLKDVLTNDQYKIYNLIWSRFVASQMTPAVFDTVAVKINQNNVLFKANGSQMRFPGFTKLYVSSRDTEDSAKDNLLPELAVGDEVKLAKTDPAQHFTQPPARYSEANLVKALEENGVGRPSTYSPTIETIQRRYYVKLNAKRFEPTELGEIVNNLIVEFFPDIVSIDFTADLEHRLDEVETGQENWIKIIDNFYQPFEKEVEKASVQIEKVQIKDEPAGFDCDICGAPMVVKMGRYGKFFACSRFPDCRNTKAIVKEIGVTCPKCGKGQVIERKSKKNRLFYGCDRYPDCDFVTWDKPVGRNCPKCEHYLVEKKIKGGKQVICPNGDYEEAVQK
(1153) DNA topoisomerase 1 [Chlamydia psittaci C19/98]
1
MESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKEFGIDIEHDFEPDYQVLPDKQEVISQICKLASSCDIVYLSPDPDREGEAIAWHIANQLPENTHIQRISFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNVRVFLQDPKTSKTFWAHLYSADGKKWEKELPKGKTEDEILLINSETQAQHYVDLLEDASYRVTRVEAKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNNVRDYIHNTFGQEYLPKSPNVYTTKKMTQDAHEAIRPTDIHLSPDKLEGKLSDDQLKLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKLDDDTTEEENLSLPQLHAQDVLDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVITDIECSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVDTPWNSPCPVCGGEMKVRHGRFGTFLGCFNYPQCRGTISIHKKGEEVEQEEAIPCPAIGCSGKILKKRSRYNKTFYSCSEYPDCSVIGNTIDAVITKYTGTAKTPYEKKTTGKKKATTKSSSKTTKTTAKKKKSEGKTPKTPKAGALLTPSPQLALMIGPEPVGRGEATKKVWQYIKDHNLQSPENKKMLLPDEKFEAIIGPEPVDMFQLPKLLNQHLFKSD
(1156) DNA topoisomerase 1 [Bacillus licheniformis DSM 13 = ATCC 14580]
1
MSEYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFIPEEYWTIEGSFLKGKETFEASFFGINGEKHQLKSEDDVKQILSRIKGNKFEVKKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAQEEAASFIGEQYGKEFLGSKRKPAKKNENAQDAHEAIRPTSVLRKPSDLKAVLGRDQLRLYKLIWERFVASQMAPATLDTMSVDLENNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKNKMLPDLAEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFIPTELGEIVLDLIMEFFPEIINVEFTAKMEKELDDVEDGNIQWVQIIDSFYKDFEKRVEKAEAEMQEVEIEPEYAGVDCEACGHPMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPSCKTGNIVERKSKKRRIFYGCDRYPECEFVSWDKPLERKCPKCEDMLVEKKLKKGVQVQCVNCDYKEEQQK
(1157) DNA topoisomerase 1 [Bacillus licheniformis DSM 13 = ATCC 14580]
1
MSEYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFIPEEYWTIEGSFLKGKETFEASFFGINGEKHQLKSEDDVKQILSRIKGNKFEVKKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAQEEAASFIGEQYGKEFLGSKRKPAKKNENAQDAHEAIRPTSVLRKPSDLKAVLGRDQLRLYKLIWERFVASQMAPATLDTMSVDLENNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKNKMLPDLAEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFIPTELGEIVLDLIMEFFPEIINVEFTAKMEKELDDVEDGNIQWVQIIDSFYKDFEKRVEKAEAEMQEVEIEPEYAGVDCEACGHPMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPSCKTGNIVERKSKKRRIFYGCDRYPECEFVSWDKPLERKCPKCEDMLVEKKLKKGVQVQCVNCDYKEEQQK
(1159) DNA topoisomerase 1 [Prevotella ruminicola 23]
1
MQKNLVIVESPAKAKTIEKFLGKDYKVMSSYGHIRDLKKREISIDEKTLEPEYEIPEEKVSLVEDLRSKAGKAETVWLASDEDREGEAISWHLCEVLGLDEQKTNRIVFHEITESAILDAIEHPRHINMDLVNAQQARRVLDRLVGFKLSPVLWRKVKPALSAGRVQSVAVRLIVEREREIQNFKSEPYYSVSGVFAVVNPDGSASEVKAQLSKRFSTEDEVMEFLEKCKTATFYADAITKKPSKRTPAPPFTTSTLQQEAARKLGFTVSQTMMVAQHLYESGRITYMRTDSVNLSQLCLNASKSEIVNLYGENYSKLRKYHTNSKGAQEAHEAIRPSYMNMTEIEGSAQERKLYDLIWKRTIASQMADAEIEKTTITIKSDGIEEVFTAQGEVIKFDGFLKVYRESSDDDENGEDYSHSLPVIKKGQELTRREILTTERFSAGPQRYTEASLVHKMEELGIGRPSTYAPTISTIQQREYVMKGDKKGEERFYSIYQLKGKQITQKTRKEMAGSERGKLLPTDIGTVVNDFLMENFPGIMDYNFTAKVEQDFDKIAEGDEKWKDMMKHFYKDFEPTVEETLNSRQKFKAGERELGNDPKTGRPVFVKIGRFGPVVQIGSSEDKDKPQFAQLPKELSMETITLEEAMELFKLPRDLGEFEGLPVSVGAGRFGPYVKHDRMFASLPKDADPMAITLDEAIVLIQEKRRQEAAKHMKFFLEDPKLEIMNGIYGPYLAYDGQNYRLPKNLHENAKDLTYDECMKIIEQMKSEEGDKKTAKRGARKGAGRKAATKKTTTKAEAEA
(1160) DNA topoisomerase 1 [Staphylococcus pseudintermedius HKU10-03]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDVEHDYEPKYITIRGKGPVVKDLKRHAKKAKKVFLASDPDREGEAIAWHLANILELEDSKENRVVFNEITKDAVKESFKHPRGIEMDLVDAQQARRVLDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYGKSKFNAKFLHYKDKPFKLATKDDVTVITKALDGNQFTVSNVTKKEKTRKPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKRKGTIGLITYMRTDSTRISKDAQNEAKQFIESEYGSAYLSKVTKKGKQGDQDAHEAIRPTSTLRTPAEMKDYLTRDQYRLYKLIWERFVASQMAPAILDTVAVDLTQNDVKFRANGQTIKFKGFMTLYVETDDDKGKEKENRLPKLEVGNEVLATKIDPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKNESKRFVPTELGEIVHEQVKEYFPEIIDVDFTVNMETLLDKIADGDVAWKKVVGDFFNSFKQDVERAEKEMEKVEIKDEPAGEDCEVCGNPMVIKMGRYGKFMACSNFPDCRNTKAITKPIGVTCPKCKKGDVVERKSKKNRIFYGCSNYPECDFVTWDKPIGRDCPKCQHYLAENKKGRATQVVCSNCDYKEEVQK
(1161) DNA topoisomerase 1 [Thermoanaerobacter italicus Ab9]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFTPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNFTKFEAKFYGTKEDKVELKTKEDVDKVLAALSEEYTVDKIKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYANPRANYASKKANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDIQEEEEKTVPVLQEGTKLLLEELKPIQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDNKNLKPTELGFIVTDALKEFFTKIVDVKFTAEMEEQLDKIEEGQAKWYEVVQEFYNDFYKTLKIAEEQMEEIDIKEEVEVTDIKCELCGRPMVVKKGRYGKFLACSGFPECKNTKPLYEKIGVKCPKCGGEVVRKKSKKGRMYYACENAPNCDFILWDKPVEEKCPVCGSMLIEKNTKNIHILKCSNPECDYHKEVK
(1164) DNA topoisomerase 1 [Nitratifractor salsuginis DSM 16511]
1
MKNLIIVESPAKARTISNFLGKDYKVVASKGHIRDLPKSSFGITVEEGKFIPKYTVPREASPTVKELKKLAKEAETVYIATDEDREGEAIGYHIAKAIGKDPEELPRIVFHEITKSAIQHALENPRRIDMQSVDAQQTRRLLDRIVGYKLSPLLANKIQKGLSAGRVQSAALKIVVDREREIKAFKPEEYWSIKGIFDKTVDADIYSFEGKKIEKMTLKNGEEANKIVESAKEESFKVASIETARRKSKTPPPFMTSTLQQAASTQLGFSPKKTMMVAQKLYEGVKTHKGTMGVITYMRTDSLNLAKEAVAEAREFIEKNFGEKYLPAKPKFYASKAKGAQEAHEAIRPTMTEFTPKLAAKYLAPDELKLYRLIYNRFLACQMTEAEFETQTILFAGEKSVFKATGRKLIFDGFYRITGYNEKDRLLPELKEEQPVELTEIKAEQHFTEPPARYNEASLIKKLESLGIGRPSTYAPTITILQNRKYIEIEKKRIHPTEIAFTVIEMLEKHFPEIVDSNFTARMEETLDKIAEGKEDWQKVLWEFYQPFIEKIAEGKKNIPSQKMAEPIGEKCPECGAELLKRKGRYGEFIACSNFPKCRYSRNIDGTEPEKPEETDEICDKCGAPMVIKNSRRGKFLACSAYPKCKNAKPLTPPKELAVPCPECGGKLIERQGRRGTFYGCANYPKCKFIANFEPVDKKCPECGYLMGVKHLKSGDVYVCFKCKHKVSAEAET
(1166) DNA topoisomerase 1 [Terriglobus saanensis SP1PR4]
1
MAKNLVIVESPAKAKTINKYLGSDYIVEASLGHIMDLPKNGIGVELKKRTFEPQLIISPGKEKLVEKLKKLAAKADAVFLAPDPDREGEAIAAHLEMQLTGSLKGKSTIQRVTFNEITKKAVIEAFTHARKVDANLVDAQQTRRVLDRLVGYEISPLLWDKVRRGLSAGRVQTVALRLIVDRENEIKAFNPVEYWPVDANLRPSGNKQNFTARLYAVDGQRISVETVGAPAFADESTTKNAVAQLEKAKWTVASVEAKERRRNAPAPYSTSRLQQDAANRLGFNVRRTMGVAQRLYEGIELGPEGTVGLITYMRTDSTRVSPEAISEARTYIKSLGEKYLPEKPNSFKGKKDAQDAHEAIRPTHVAMTPEKIKKFLSDEQYRLYRLIWQRFVASQMTAAVYDQTAVEIEAKADRTYNLRVTGSVLKFDGFLKVAEPAKSDAMVQKTADAMKTENPGEGEEDEDKSLPALKAGQALDLVDIVTEQKFTEPPPRFNEASLVKELEERGIGRPSTYASIINTIQERDYVKKISKKFIPTEIGMVVTSLLVKNFPYIFDMAYTAKLEDELDLVESGEEKWTSLLDGFYTHLTDEIKIASEEMEEIKRWEKPTDEKCEKCGSPLILRWGKFGSFYACSNYSKIKPMTIAVSGYKKDAKAVATKITAKFKFPFAIKGMVDDAEAFSEEVHDAKELTAALKLAAERGKKIVADPVSCDFTKENYADKPDLAAGDAQGTEEEEEYCDNCGKQMVLKNGPWGPFMACQDYNADPPCKTVRRLNQKVQQKPPEPTGEPCPLCGMELVKRTGAYGEFVSCSGYPKCKYVKQVLLDVPCPKDGGAIAERKARTGNYFYGCTNYPKCDFTSNQKLVSGPCPKCNSSYLLEVAKEGTIHLVCPNNTEALPKRRKKKGAEEVTTPVVECTFEKDTGVAVETAPAKEATPLARPDPEKTRPLVEAVA
(1171) DNA topoisomerase 1 [Geobacter lovleyi SZ]
1
MAHQLVIVESPAKAKTIEKFLGSEYRVLASFGHVRALPSKQGSVDTANDFEPKYHVLPESKKHIDAIKKELKGADRLLLATDPDREGEAISWHLLAALGLDKKPKIPIQRVVFHEITKDAIIHAVQHPRDIAIDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFVDQEYWTIGAKLEKQGGQTLKAGLVAVDGKKLGKFDIPDQKSADALKNAIAQGKAEVASVTRKEMKRNPAPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGVAIGEGGTVGLITYMRTDSVNLSAQALKDAHDLISVAYGKEYALAKPRFYKNKSKNAQEAHEAIRPTYLDKTPAELKKYLTPDLFKLYELIWKRTVACQMAEALLDQTSVDIAVSGQKTDSFILRATGSVIRFPGFMKLYIEGVDDEDEEKEGTLPALDEGEALKLLEVLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASTLNTLVERKYARLDKKRFFPEDVGMVVNDLLTAHFPKYVDYNFTAGLEEELDQVSRGEKQWKPLLREFWNPFISLLKQKEGEVKKDDLTTETLEEACPECGKPLAIKLGKRGKFIACTGFKEGCKYTRNLENSGTEEAAEPEVSEEKCDKCGQPMLIKSGRYGKYLACSGYPACKNIQPLNKPKGTGVTCPECKEGELTEKKSRYGKMFYSCNRYPDCKFALWDPPVTQPCPKCGFPVLVKKVYKKKGEFLKCPKEGCDYTSA
(1176) DNA topoisomerase 1 [Leuconostoc gasicomitatum LMG 18811]
1
MVETKNKTTKLVTKKTTKRKRAKVKKNLVIVESPSKAKTIEKYLGSSYKVVASLGHIRDLPKSTLGVDVENDYDPKYINIRGKGDVIKGLRKEAKAAKKVYLASDPDREGEAIAWHLQHILELNPEEPNRVVFNEITKDTIKNAFKIPRKINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIISRERKIQAFEPEEYWTLDSEFKKSRSKFKSSFYGFDGKKQPLPDNESVQYVLKQIDQSADFNIVKVEAKERKRNPQQPFTTSTMQQTANTQLNFRTRKTMMAAQQLYEGVNLGRGIGQIGLITYMRTDSTRISSLARNAAALYIHDTWGEAYSQHKPIQGKLPEGAQDAHEAVRPTDVTRTPESIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNNVVFRANGSKTKFQGFTKAYPAAKEKDNALPDLSVGDKVKLTNTNPEQHFTLPPARYSEAALIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVEESFPDITDTHFTASIEHELDEVEVGDKHWVPVIDSFYKPFSKEVEQAAATLEKVIMHDELAGMNCETCGAPMIVKMGRYGKFYACARFPDCRNTQTIIKEIGLLCPKCHKGQIVERKTKRQRTFYGCSRYPDCEFVSWDKPTEKTLADGTTPKVPEDEVSKA
(1178) DNA topoisomerase 1 [Clostridium cellulolyticum H10]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAIKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVRKGLSAGRVQSVATKMICDREDEIEKFESQEYWSIIAKLVKPKASPNFGAKFYGIGKEKLELTNEEQVNSILEEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGYTTKRTMMVAQQLYEGIEIKGRGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPEKPREYKNKSASQDAHEAIRPTYIDLPHEQIKEYLSPEQYKLYRLIWDRFISSQMSSAIYDTVSADITAGKYLFKANGSKVKFPGFMVLYTEGNDNEGKDEAEQDEKENKLPQLNEGDILELKENTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAEMESELDSVEDGDKEWKAVMRDFYSSFAGVLKKAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNAKPIVEEAGVECPICKGKVLIKKTKKGRKYIGCEKNPECPFMSWDMPSPNKEVCSVCGSFMLQKFSGKKKVLKCSNDKCTSNIEASKDNTK
(1186) DNA topoisomerase 1 [Paenibacillus mucilaginosus KNP414]
1
MADSLVIVESPAKAKTISKYLGSKYIVKASMGHIRDLPKSQIGVEVKKNFEPKYITIRGKGSVLKELKDASKRVKKVYLAADPDREGEAIAWHLAHYLELSDQDACRVVFNEITKQAVKDAFKTPRKINQDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKLIYDRENEIKAFEPEEYWTITAKLAANKSDFEAKFYSVNGEKKELKSQSEVNEVLALLGGSDFVVSEVKEKERLRNPSPPFITSSLQQEAARKLNFRAAKTMSVAQQLYEGIDLGSEGTVGLITYMRTDSTRISPVAQEEAKEYITGKYGEAYYPAEPRNYVKKNANAQDAHEAIRPSSVLREPESIKAHLSRDQFRLYKLVWERFVASQMASAVLDTMTVDLNAGPVVFRAVGSKIKFHGFMKVYVESSDEGAADAADDDKFLPPLKQGDEAKPQAIDPKQHFTQPPPRYTEARLVKALEEMGIGRPSTYAPTLETIQKRGYVAIEEKKFVPTELGELVIQQMIEFFPEILDVEFTAHMEEGLDHIEEGKEDWVRVLSEFYDSFEKRLEVAEEEMEKIEIQDEVSDEICEKCGNHFVYKMGRFGKFLACSGFPDCRNTKPIVKDTGVTCPSCHEGKIIERRSKKGRIFYGCDRYPACEFVSWDKPVEQPCPKCGALLVEKRNKSGTFIQCVSCDFKEEAKEDDRED
(1189) DNA topoisomerase 1 [Geobacter uraniireducens Rf4]
1
MPRHLVIVESPAKAKTIEKFLGTDYKVLASFGHVRALPSKQGSVDIEHDFEPKYAVLPESKKHIDAIKKELKNSDSLLLATDPDREGEAISWHLLAALGLDKKKPAIDIKRVVFHEITKGAIIHAVENPRSISHELVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFTEQEYWTIAAQLATGAQQNVTANLVEAEGQKLGKFGIPDKAAAERLTEILANGSYQVDKVTRSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSIAQKLYEGIDVGEGTVGLITYMRTDSVVLSQQALDEAHEVITSLYGKEYALAKPRFFKNKAKNAQEAHEAIRPTYICKTPVELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGYKFRAAGTVIRFPGFMKLYIEGVDDETEEKEGVLPPLNEGDPLKLKELLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYARLDKKRFFPEDVGMVVSELLVNHFTKYVDYNFTASLEEELDRVSRGEKKWKPLLHDFWEPFQTLLKQKEGEVNKSDLTTEATDEICPECSKPLVVKLGKFGKFFACSGYPECKYIRPLDKDKKDVAEPVISEEKCDKCGSQMLIKEGRFGKYLACSAYPACKNIQPLVKPKGTGIKCVECGEGELTEKKSRYGKMFYSCNRYPQCKFALWDLPVEKPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYKEGGKEK
(1192) DNA topoisomerase 1 [Dyadobacter fermentans DSM 18053]
1
MSKNLVIVESPAKAKTIESYLGQDFTVKSSFGHVRDLPEHDMGVDVEHGFQPSYEISSDKVKVISELKKLAKDAEVWLATDDDREGEAISWHLKEALGLPDNTKRIVFREITKTALRNAIEKPRTIDTALVDAQQARRILDRLVGYELSPVLWKKIRIGKSNLSAGRVQSVAVRIIVEREREIDAFKSKSSFRVTAHFDLGNGKVLNAELAKNIPTEQEAQQFLEKCVGAEFSIRNLEVKPAKKSPAPPFTTSTLQQEASRKLSFSVAQTMTVAQRLYEAGKISYMRTDSTNLSEEALDKSKQQITKEYGIDYYNRRIFKTKSESAQEAHEAIRPTDFSTLLGSSDRNEQRLYELIWKRAIASQMSDAQLERTTATIGISTTSEELVAQGEVIKFEGFLKVYLESSDDEGDEEQKGMLPPLNIGQILKLADMKATERFTRNPPRYTEASLVKKLEEMGIGRPSTYAPTISTILKREYIVKEDRQGFEREFKEITLANEQIKSKVNKEVYGSEKAKLFPTSTGMVVNDFLVSHFQDIVDYSFTASVEKDFDHIADGQLEWQQMIKNFYTPFQKKVAEAREEAIDKSLTSRELGEDPATGKKVSVRIGKYGPYVQIGDVEDEEKPRFASLQKGQLMETITLDEAFELFKLPRQVGFFEDKDMIVNVGKFGPYVKHDGKYYSLAKTDDPMAVTEDRLVEIIEEKRLQDSNRTIKEFAEDPEAKVLNGRYGPYIAFGKKNVKIPKGTEPASLTYEQVLKLAAETPDKPAGRGGARKPAAAKAPAAKKPAAKKAAKK
(1197) DNA topoisomerase [Carnobacterium sp. 17-4]
1
MEKVKKGLSAGRVQSVALKLICEREDEINRFEPEEYWSIGANFKKDKKKFKANFYGLKGKKQALSNAEDVQKIIKELDGDQFEVMSVTKKERLRNPALPFKTSSLQQEAARKLNFRTRKTMMVAQQLYEGISLGRGGAVGLITYMRTDSTRIALSAKNEAAEYIIKEFGPEYAASKPRIGKKAEGDQDAHEGIRPSSVLRTPKEVEKYLTKDQYKLYNLIWSRLVASQMTPAVFDTMKVDIAQKDVYFRANGSKVKFPGYQKVYIEGNDEGKEEKDNLLPEMEKGDKVKSIDIEPKQHFTQPPARFSESTLIRVLEDNGVGRPSTYAPTLETIQRRYYVKLQNKRFEVTELGGIVNGLINEFFPQIVDVHFTADMEKNLDEVEEGNKEWEKVIDQFYQPFAVEVEKAEENMEKVQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKPIVKEIGVACPVCGEGHVIERKSKKNRIFYGCDRYPTCEFVSWDKPVGRSCPKCEHYLVEKKAKGSKQVICSNCDYKEEVQK
(1201) DNA topoisomerase 1 [Streptococcus thermophilus JIM 8232]
1
MATATTTKTKAKKKTKAKKATKKRATPKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLIKELKKEAKKAKKVFLASDPDREGEAISWHLSHMLGLEPEDKNRVVFNEITKDAVKNAFAEPRAIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGAFKKGAKKFQASFYGLDGKKLKLNNNDDVKDVLSRIISDDFNVDKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGINLGSGAQGLITYMRTDSTRISPVAQNQAAEFITERFGSKYSKHGSKVKNSSAAQDAHEAIRPSNVFQTPESIAKYLDKDQLKLYTLIWNRFVASQMAAAVFDTMKVTLSQNGVIFTANGSQIKFDGYMAVYNDSDKNKMLPEMAEGDTIKKVVTTPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVKLVAKRFEPTELGEIVNSLIVEFFPDIVDVKFTAEMEAKLDKVEIGKEQWQKVIDEFFKPFQKELEKAEEGIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVTCPTCGQGQVIERKTKRNRVFYGCDRYPDCEFTSWDIPIGRNCPKSGDYLVEKKVRGGGKQVICSKEECDYKESVIK
(1205) DNA topoisomerase 1 [Ochrobactrum anthropi ATCC 49188]
1
MNVVVVESPAKAKTINKYLGSNYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSSKRLADIVKALKDSDGIILATDPDREGEAISWHVLEVLNQKKALKGKTVKRVAFNAITKKAVLDAIANPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVADRESEIERFIREEYWNIAALLKTPRNDGFTARLTAVDGKKLGKLDIKNGEQATAIRTMLEGASFKALSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIGKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRYLDDDQARLYELIWKRAIASQMQAADIERTTVDIEAVNSSRSAMLRANGSVTKFDGFLAAYMDHREEEDDDEDSAKLPEIRSGEALAREKIDATQHSTEPPPRYSEASLIKKMEELGIGRPSTYAATLATLRDREYITIDKRKLIPEPKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKDVLRDFWRDFSGNVDDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGMLSLKLGKYGAFVGCSNYPECKYTRQLGGDANGESAAADEPKSLGKDPFTGEEITARTGRFGPYVQRGEGKEAKRASLPKGWTVDTLDHEKAVALLSLPRDIGQHPETGKMISAGIGRYGPYVSHDGTFANLENAEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGSITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKSKKTPARKASASTEKKAAAKKPAAKKAPAKAKSTAKPKAKSKAETVEE
(1206) DNA topoisomerase 1 [Rhizobium leguminosarum bv. viciae 3841]
1
MNVVVVESPAKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVLPDQDFEMLWEVDSASAKRMKDIADALKSSDGLILATDPDREGEAISWHVLDMLNKKRALTGKSVKRVVFNAITKKAVLDAMAAPRDLDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFISEEYWNISALLKTPRGDEFEAKLVSASGKRLQPRAIGNGEDAGRLKALLEGASYVVDSVEAKPVKRNPGPPFTTSTLQQAASSNLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIDAARSAIVDQFGERYMPEKPRFYSTKAKNAQEAHEAIRPTDFDRSPDRVRKFLDADQIRLYELIWKRGIASQMASAEIERTTAEITADNKGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDEDGRLPEINAREALAKQKINSTQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLATLRDRDYVTIDKRKLIPQAKGRLVTAFLESFFTKYVEYDFTADLEEKLDRISAGELNWKQVLRDFWKDFFAQIEDTKELRVTNVLDSLNEALAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPDCNYTRQLSSENGGEADGAALNEPKNLGTDPTTGEELTLRSGRFGPYIQRGDGKEAKRASLPKGWKPEDIDYEKAMALISLPRDIGKHPESGKMISSGIGRYGPFLLHDGSYANLETVEDVFSVGLNRAVTVIAEKAKQAPGRGARGTPAALKTLGDHPDGGAITVRDGKYGPYVNWGKVNATLPKGKDPQAITVEEALALIAEKAGKAPASKTAKAKAKPKAAAAAAKSTKTAAKPKATKAKAPAKSKKG
(1207) DNA topoisomerase 1 [Rickettsia peacockii str. Rustic]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKTGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTQVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAVRKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGTLEWKAALNNFWSGFNHNIESVNEQNITEIISYVQKALDYHLFGENKESKICPSCHTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(1210) DNA topoisomerase 1 [Roseburia intestinalis M50/1]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVVASNGHVRDLPKSQMGIDIENDFEPKYITIRGKGDILAKLRKEAKKADKVYLATDPDREGEAISWHLSQALKLDDKNAQRITFNEITQNAVKASLKEPRKIDMNLVDAQQTRRILDRLVGYEISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWTLDAELSVKGERKTLLAKFYGDENGKLTISSKEQADRIMAEMQKEEFHVLEVKKGERVKKAPLPFTTSTLQQEASKALNFPISKTMRIAQQLYEGVDVKGQGTVGLITYLRTDSVRISEEADAQAREYIAGNYGENYIAGEKTTKKNGAKIQDAHEAIRPSDINRTPVMVKESLSRDQFRLYQLIWKRFTASRMAQAVYETTNVKIGAGEYRFTVSASKIAFDGFMSVYTSDDDEKAENNVLVGSIDENTVLNLKEFDEKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTITTLLGRRYIVKEAKNLYVTELGEVVNQIMKESFPSIVDEHFTANMESLLDGVEEGNVNWKTVVRNFYPDLDEAVKAAQKDLEKVKIEDEVTDVICDVCGRNMVVKYGPHGKFLACPGFPECRNTKPYLEKIGVTCPKCGKEVVLRKTKKGRKYFGCEDNPECDFMSWSRPVAEKCPKCGGYMVIKGNKIVCADEQCGYVTDRKNVEKDSE
(1212) DNA topoisomerase 1 [Thermoanaerobacterium thermosaccharolyticum DSM 571]
1
MEKSLVIVESPSKAKTIHKYLGKNYKVEASMGHIRDLPKSQLGIDIEKNFEPKYITIRGKGPIIEKLKKEAKNASKIYLATDPDREGEAISWHLANLLNIDVNDKCRIEFHEITKNAIQNAIKNPRKINMNLVDAQQARRILDRLVGYNISPLLWKKIKRGLSAGRVQSVATRLICDREKEIEEFKPEEYWSLSAFLYKEKKTQYFEAKFYGTKDGKIDLKNENDVNNIIKDLADDYIVDNVKTGTKKRNPSPPFITSTMQQEASKKLGFTAKKTMMIAQQLYEGVEIKGEGSLGLITYMRTDSTRISEEAKKAAYEYILQKYGKEYANPNTTYTKKGGNIQDAHEAIRPTYINLDPDQIKDSLKPDQYKLYKLIWSRFLASQMSQALYDTITMDIINKNYIFKASGSKLKFAGFMTVYIEEADTENIEEKTLPLLEKGDHLKLKVLKPEQHFTQPPARYTEATLIKELEEKGIGRPSTYAPIISTLLERGYVIKEKKNLKPTELGFIVTDVMKEFFPDIVDVKFTAEMEEQLDKIEEGIEKWCDVIDGFYNNFNDSLKVAEEQMKDIEIKDEVTDIKCEFCGRNMVIKYGRYGKFLACPGFPECKNTKPLYEETGIICPKCGGKIIVKKSKRGKTYYACENSSQCGTMFWDKPINETCPKCGNLLMEKYIKGNKVIKCSNCDYVK
(1214) DNA topoisomerase 1 [Faecalibacterium prausnitzii SL3/3]
1
MAKLVIVESPAKAKTIGKYLGDDYEVTASMGHIRDLPASQLGIDVEHGYTPQYISIKGKEKLIKELKSKAKHADGVLLATDPDREGEAISWHLANILGLDPHEPNRVTFDEITKKGVKEGMAHPRAIDEDLFNAQQARRVLDRLVGYKLSPFLWRKVRRGLSAGRVQSVAVRLIDDREKEIENFKPDEYWNVDATLGAGHKSFVARLATDANGKKLLPKSEAEARAIEKGLEGASYVVSELKRGKRAKQPTPAFITSTLQQEASRRLGFTATRTMRAAQTLYEGVDIAGHGMMGLITYMRTDSLRISDEAVAAAKEYIAGAYGEAYICPYKRTWKTKSATAAQDAHEAIRPSVPSLTPDEVDKSISGDTAKLYRMIWSRFMASQMADCQQDTVSVTVSAADYHFKASGYTVTFDGFTALYEEATDEKEKKETNLPPLEQGQVLKLRELKSEQKFTQPPARYTEATLIKALEENGIGRPSTYAPIITTIIDRGYVERDQKKLKPTLLGRAVDGLMLEQFPHIVDVDFSAQMEKNLDKVESGKADWRKTVDDFYQGFEASLEQAEKNMEGKKVKVPDEPSSEVCDLCGRPMVIKVGKYGKFLACSGFPECRGTKRLVKDTGGICPKCGKGRLLERKSSKGRIYYGCECYPDCDFMTWDMPVATKCEKCGSTLFRKGGKLYCAKEGCGFEMPVPKKD
(1215) DNA topoisomerase 1 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
1
MSKHLVIVESPAKAKTIQKYLGNDYDVLASYGHVRDLPARKGSVNPEKHFSMTYVPIEKNARHIDTIAKTLKKSDSLLLATDPDREGEAISWHIFELMKERNLLKDKSVHRIFFNEITKAAIQDAINHPRSISMDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVEREEEIERFIAQEYWKIIAKCAHASTEFEARLTHYNEEKLQQFSVTQQEQAHEIKKQLIAQAQGFLTVAQIDKKQRKRKPSPPFITSTLQQEAARKLGFTARKTMMVAQQLYEGIDIGTGTVGLITYMRTDSVNLAKEAIDEIRDYITQRYKGDNCPNSPRIYKTKSKNAQEAHEAIRPTSIKRTPEMVQGSLTSDQLKLYSLIWKRTVASQMADAILDTVSVDFSCGKGNTFRANGSTIAFPGFLSVYEEGRDDSKDEDNEDKILPAFNVGEKIKVSDIETNQHFTEPPPRYSEATLVKALEEYDIGRPSTYASIIHTLQQREYVVVEKKRFLPTDVGRIVNRFLTNYFTRYVDYQFTAGLEDTLDAIARGEKDWIPVLEEFWQPFVQQIQNIDEQVQRKDVTTELLDEKCPKCQKPLSIRLGKRGRFIGCTGYPDCDYTQDISNPEGEKSEPEVVEGRSCPLCHGALHIKTGRYGKFIGCSNYPECKHMEPLEKPSDTGVTCPKCSQAKILQRKSRKGKIFYSCGNYPKCDYALWNEPLDLPCPKCAWPILTLKESKKFGRQILCPREGCDYSAKED
(1217) DNA topoisomerase 1 [Neisseria meningitidis MC58]
1
MAKNLLIVESPSKAKTLKKYLGGDFEILASYGHVRDLVPKSGAVDPDNGFAMKYQLISRNGKHVDAIVAGAKEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPREIEMDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIRAFEAQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQFDLPNEAAQADVLKELEGKEAVVTAIEKKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDSVNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPFLSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFAGFLSVYEESSDDEEGEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEYGIGRPSTYASIISTLKDREYVTLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLEDQLDEIADGKRQWIPLMDKFWKPFIKQVEEKEGIERAKFTTQELDETCPKCGEHKLQIKFGKMGRFVACAGYPECSYTRNVNETAEEAAERIAKAEAEQAELDGRECPKCGGRLVYKYSRTGSKFIGCVNYPKCKHVEPLEKPKDTGVQCPQCKKGNLVERKSRYGKLFYSCSTYPDCNYATWNPPVAEECLNCHWPVLTIKTTKRWGVEKVCPQKECGWKEQIEPPAPKE
(1221) DNA topoisomerase 1 [Sphingomonas wittichii RW1]
1
MKLVVVESPAKAKTIEKYLGPGHRVLASYGHVRDLPAKDGSVDPDNGFAMEWEAYADKSRQLKAIADEAKGADTLILATDPDREGEAISWHVKEVLGKRRVLPKDVRRVTFNAITKAAVTEAMANPRDLDEDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVDREREIELFKAQEYWSVTADMEYDGIGFLTRLVRWKGQKIDRLTIGNGKDAEAAKADVEAGRFTVASVETKPLTRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQALYEDGAITYMRTDGVQMDGSAISAARGAIANRYDASYVPDKPRQYSAKAKNAQEAHEAIRPTDFSRDRAGSGDHGRLYDLIFKRALASQMASARLERTTVDLVDGTGQNALRATGQVVLFPGYLALYEEGRDDPNPQGQQAGGGDADEDSRRLPRMKEGDSPAKKKVDAEQHFTQPPPRYSEASLVKKMEELGIGRPSTYASILQTLKDRDYVTVEKNRFTPNESGRLVTSFLERFFERYVSYDYTAHLEEELDDVSGGRAGWQQVLEAFWKDFKPKTAEVMDQKPSEVTAALDEFLAPYLFPDKGDGTDPRLCPVCQEGRLSLRGGRFGAFIACSNYPECKFTRRFAQAGAANDGADTGPVVIGTDPATGLEVSKRAGRFGPYIQLGDGKDAKRSSIPKDVLGDDLDLGWALKLLSLPRLIGPHPETGHPITASIGRFGPYLAHDGKYARLGSTAEVFETGMNAAVVKLAEAANGGGRQRGKAEPLKTFGASPVTGSEVKLMAGRFGPYVTDGETNATLPKTANPDELTAEAALELLAARAAKGPPAKGKKKAPAKKAAPKKAAAKK
(1222) DNA topoisomerase 1 [Bacteroides salanitronis DSM 18170]
1
MQNNLVIVESPAKAKTIEKFLGDGYKVLSSYGHIRDLKEKSFSIDVKNHFAPIYEIPADKVKLVNDLKKEAKKADMVWLASDEDREGEAISWHLYEVLQLEPEKTKRIVFHEITKTAILNAIKHPRTINIDLVNAQQARRVLDRIVGFELSPVLWKKIKPSLSAGRVQSVAVRLIVEREREVQAFVSEALYKVTAVFANAKGEEFRAELGRRFKTKKEAQAFLEKCKKAEFEIEDITTKPMKKSPAAPFTTSTLQQEAARKLGFTVAQTMRIAQLLYENGLITYMRTDSVNLSDLALDTSREAIVSRMGEKYVQTRHYTTKTKGAQEAHEAIRPTYMSNETIEGTGQERRLYELIWKRTLASQMADAELEKTTATISISGEEDKFIAVGEVVTFDGFLRVYKESYDEGAEPEGEMRLPSALAVGQALAYKEITAMERFTQAPFRYTEASLVRKLEELGIGRPSTYAPTISTIQQRGYVEKGNREGTERPYRILSLQGGKIEESTKVELTGSEKAKLLPTDVGIVVNDFLKEYFPQIMDYNFTASVEKQFDEIAEGEKQWGDVMEHFYEGFHPLVEETMASRSEHKVGERILGTDPASGKQVSVKIGKYGPVVQIGTAEDAEKPRFAQLQKEHSLETITLEEALDLFKLPRTLGELEGKEVSVGNGRFGPYVRCDNQFVSIPKPMDPLSITLEEAVQLIREKQDAAAKRVIKTFPENPDLQILNGKYGPYISYEGKNYKIPDSIDASFLNMEACFKVIELQKEKAETRKIRHTAKRK
(1229) DNA topoisomerase 1 [Waddlia chondrophila WSU 86-1044]
1
MSKSLIIVESPAKMKTLKKFLGDAYILESSVGHIRDLPEKEFGIDIENEFEPKYVTMPEKEKVINSLKKAAKNVDTVYLSPDPDREGEAIAWHIMNILPKGTVYKRISFNSITKDAVLKALQFPRDIDMALVDAQQARRLLDRIVGYKISPILNRRIQRGRDGGVSAGRVQSVALKLVVDREAEIEAFIPVEYWNLAAILKAARDSRSFKANLYSVDGQRVEKEAVEGKNFFLIPNKETADQVIERMQSGPFTVQTVVKKEKKRNPVPPFITSTLQQEASRHHGYSSAKTMNIAQSLYEGIDLGNEGAEGLITYMRTDSVRVAPEALDEVRKHIKEVYGKDFLPESAKMYTTKKAAQDAHEAIRPTNLAHTPEHVKSYLTREQYMLYKLIWQRFVASQMNPAIYDTVSADISAGSEIIIRATGSVIKFQGFLAVYEEMEDDVETAEDGKILPPLEEGMELTLLELTSDQAFTRPPPRFTEASLVKELEKSGIGRPSTYASIMNKIQGREYTIKENSRLKPTELGRVIAQMLETNFPEIMNIGFTAQMEDDLELIASNEKDWKKLIKDFWESFYPTLEEAEKNAFVPKILTDIDCPECGSKLQKVWFKSKYFYGCSSYPDCSYSAPAEEILFNKEDYAEGFNWEQKCPLCQSEMKVRHGRFGAFLGCTKYPECRGIINIPKKGEEIINPEDLPPCPATDCTGQIVARKSRFGKTFFSCSSFPDCDVIVNDLTQLQSKYVDHPRTPYVKKTKKGKRGRPTKADKEKGKKTQAKKKRNVAPSALSPELAEIVGSHEATRGDALKSVWAYIKSNKLQDPENKRVIKPDEKLGKVFGNMEPVDMFKIAGILSQHIGKKD
(1230) DNA topoisomerase 1 [Wolbachia endosymbiont strain TRS of Brugia malayi]
1
MALLIVESPAKARTISKYLSKEFKVAASFGHVRDLPVKNGSVDPDNDFAIKYEIIEKAEKYVKELVKEASQTSDIYLATDPDREGEAIAWNVIEALKERKAINDKSNIYRVVFNEITKRAVQEAVKNPREINMDLVRAQQARRALDYLVGFSLSPLLWTKLSGSKSAGRVQSVALKLICEREDEISKFVSQEYWSIRAEIKDSKGETFFAMLSHYDNKKLEKFDIKNEEEAKGLVKQIESRQYAVSTVERKQVKRNPLPPFITSSLQQDAVNKLYFNVKNVMRIAQDLYEGIDIGGETVGLITYMRTDGFYIADEAVNSIRRSIKSLYGNKYLPKSSRQYVKKVKNAQEAHEAIRPTDIDRTPDSIKDYLTPEQFKLYGLIWKRTIASQMESAILDQVVVEISSTDQKVILRASGSIIFFDGFYKVYKNNVDGEDESMIPTMKEGEECKLISVDPEQHFTQPPSRYSEASIVKKMEEIGIGRPSTYAAIISVLQDREYVTLDNKRFIPSSRGKIVTIFLETFFQRCVEYDFTAQMEEKLDLISNGRADWKKELGYFWVPFFNHVNSVKQMTHDEIFNGIRDLVVDWFCSEEGKKEVNKKCPDCPDGILKLNFGKAGVFLGCSNYPTCTHTKEITGSNDNSEYPKSLGIDGVTEQEVVIKKGPFGLYLEFNSESEKKKTVSIPKDINVNDIDLSTATRLLSLPKVIGEHPETGKEVKIGLGRFGYYIFYDSKYFSLKKSFKEVLEIQLDEAVQIIANSPRKELKSLGFNEKGKEVFICNGRYGFYIKCGKTNVALGKNADIESVDLRRALELIKSKK
(1231) DNA topoisomerase 1 [Halothiobacillus neapolitanus c2]
1
MSQTLVIVESPAKAKTIKKYLGPGYEVLASYGHVRDLIPKDGAVDTAHDFAMNYTLIDKNVRHVDAIKKALKSSDILLLATDPDREGEAISWHLRELLAEAGLLKNKTAQRVVFYEITKKAVQEAVAHPRDLSIDLINAQQARRALDYLVGFNLSPLLWKKINPGLSAGRVQSPALRLIVEREAEIEAFNPQEYWTILADCQADRAAEKSRFNARLLTLDGQKAEQFTLTNETDAQSARSRILEAAAGTLTVRSVEKRERKRNPAPPFTTSTLQQEGVRKLGLSASRVMRLAQELYEGVDIGAGTVGLITYMRTDAVTLSEDALTQIRAHIGDKYGAAYLPASPNRYKTKSKNAQEAHEAIRPTSAAHTPDSVRAFLNKDQFRLYEMIFKRAVASQMTPAVYDQVSVDLAVNDQHSFRANGSTLKFPGFIALYREDEDDASGDNDEDRRLPPLTVGDKIALNDIAADQHFTEPPPRFTEASLVKTLEEYGIGRPSTYASIISTLQAREYVLLDQRRFKPTDMGRVVNGFLTDYFRDIVDYEFTAKLEDDLDAVSRGERDWVPLMREFWTPFHDRVEHTNENVTRQEAAQGRELGIDPKSGKPVSVRLGRFGPFAQIGTKDDEEKPKFASLKRSQSIATITLDEALDLFQLPRKLGETPEGEPVEVAIGRFGPFVKFGKMYASLGKDDDPYTIELPRALEIIEIKKLAEKNRYITQFDNGVSVQNGRYGPYITDGKKNAKIPKDKDPKSLTLEECVALLAAAPEKKSARGKTAAKATAKKTAAPKATAPKTTAKKSTTPRAKKASATDAQAPAKKTPVKKPATARSKKPAATIPE
(1237) DNA topoisomerase 1 [Thermovibrio ammonificans HB-1]
1
MGKKLIIVESPAKAKTIQKYLGKDFIVKASMGHVIDLPEKEFGVDIEKGFKPKYTTIKGKEKVLKEIKEAAKKSDEVYLATDPDREGEAISWHIANALKRVKKDNIYRIRFHEITKRAIQEAVKNPDTIDEKKVNAQQARRILDRIVGYTISPLLSRRFKRALSAGRVQSVALRLICDREEEIRKFVPKEYWTVEAKFAKGSEELPAKLWKVDGKRLEKFDIPNEKAAKELVERAKGAAFSVAKVERKERRRKPPAPFITSTLQQEASRRFGFPAKVTMQIAQELYEGIDLGSERVGLITYMRTDSTRVSDEAVKEVREFIKEHFGQNYLPKTKRSYETKKPKSAQDAHEAIRPTSVFRTPESVKPYLTPEQFKLYDLIWRRFVASQMKDAVFNTVSVDVEGGGLTFRSTGSTLKEEGFLKVYPVEVEEKLLPELNKGEALELKEVKGVQHFTEPPPRYTEGTLVKALEEEGVGRPSTYATIISNIIQRGYVAKEKQKLKPTELGEFINSLLKKLFPKIVDVKFTANVEEELDKIEEGQKEWKELLKEFYFGEFKELLDRAEKELKQIKGEEIGRECPRCGAPLVKIHGRYGAFIACSAYPECTYKESIKEEPQKLDRKCPECGGELVIKNGKFGRFIACSNYPECKHTEPLTFGKCPKCGEGEVVERRSKKGKRFYGCSRYPDCDFVSSKPPKGGES
(1238) DNA topoisomerase 1 [Cyanothece sp. PCC 7425]
1
MTNLLIVESPGKINKLRTILGSGWEVKASVGHIRELANDGPDSLGFDLGRDRIDCRYIPRNPRAKQAIAALKQAARQAQSVYLASDPDREGETIAWHIAEVLGLKQPQRIVFQEITATAVRTALSRPRPLDLNLVAAGRCRDCLDKLVGYKGSPLVWRLQNGAKSVGRVQSATLHLLCLREREISSFVPQTYWSVYVDYQEGFRAYYHHANQPPDPKASPEGIDEAGSQDSNKESTRVVSREAAEHLVVIARSQPHRVQQVSGQVTSKKPPPPFITSSLQQAAGSRLKFNPEYTMSLAQKLYEAGLITYMRTDSVQLSPEFCTAARSWLQEHDPENVPQRVARQRSSKAAQEGHEAIRPTDVFKSSAELRLQLEDDQFKLYVLIWTRAMASQCKSAQIRKTRILSQSGKVQWQATGQVIEFPGYTKYWKDISADLVLPEVTEGQPLHLETAQHEEKQTQPPPRYTEPKLVQLMERKGIGRPSTYAPTIATLKQRNYVHLLKDKLQPTDLGLQVDAFLETALPDLLKAEFTAAMESSLDAIAEGQQEWQRYLIDWNHTYFEPALQAALNRLPEHKGNTERKPLEKSRLKCPKCGQSMAKVPSQKVSKGYFLKCEVGCQTAAGKAMVMFWSARSKKWQLPEPHTEPQQENSDAKRQQDLQTKQLPVLTEHFCPVCNAYLEEYTYQREGQSKKLLRCSIPDHRQSKCKEATYFLTRQGEWWSKKFGQLE
(1241) DNA topoisomerase 1 [Bacteroides helcogenes P 36-108]
1
MQKNLVIVESPAKAKTIEKFLGKDFKVLSSYGHIRDLKKKEFSIDVEKDFEPHYEIPTDKKKVVAQLKEEAEKAETVWLASDEDREGEAIAWHLYEVLKLKPENTKRIVFHEITKGAILKAIENPRNIDINLVDAQQARRILDRIVGFELSPVLWKKVKPALSAGRVQSVAVRLIVEREREIHAFRTEASYRVTAIFLVPDADGKQVEMKAELARRIKTKAEAQKLLESCKSAAFIINDITTRPVKRTPAAPFTTSTLQQEAARKLGFTVAQTMMVAQRLYESGNITYMRTDSVNLSEYAVNSSKEAVMHLMGERYVFPRHFATKTKGAQEAHEAIRPTYMENTKIEGSPQERKLYELIWKRTIASQMADAELEKTTVNISIGNEADTFTATGEIVKFDGFLRVYRESYDDDSETSEDEARLLPPLKKGQKLQYEDITATERFTQHPARYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVVKGEKPGEERAYNVLSLQNGQIADTTRTEITGAEKAKLLPTDTGIVVNDFLIEYFPNILDFNFTANVEKQFDEIAEGDKQWTAILNTFYKNFHPSVESTLATKSAHKAGERILGTDPSTGKQVSVKIGRFGPVVQIGTAEDEEKPRFAQLNKDMSIETVTLEEALDLFKLPRTLGEYEDKTVTVGTGRFGPYIQHNRVYVSLPKTADPMTVTLEEAIELIQEKQQAEAQRHIKKFEEEPELEIMNGRYGPYVAYKGSNYKIPKDIVPQDLSLTACLEIVKLQSEKTPSSKSKRGAKAATKTAKATTSKTTVKKTKATATKTAEKK
(1242) DNA topoisomerase 1 [Magnetospirillum magneticum AMB-1]
1
MRMKVVVVESPAKAKTINKYLGSDFHVLASYGHIRDLPPKDGSVRPDEGFAMDWETDPKSERQIKEIVAAVKGADKLFLATDPDREGEAISWHVRQVLEARKALKGVEVKRVVFNEITKSAVLDAMRNPREIHQELVDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICERESEIESFKPREYWTIAADFLTPKGALLSAGLTHLGGKKLDKFDLSSEALARDAESKAASARYAVAAVERKRTRRNPYPPFTTSTLQQEASRKLYFAAARTMQLAQRLYEGVDIGGETVGLITYMRTDGVQMAAEAIAGARAVIAQDFGKVYVPEAPRVYKTKAKNAQEAHEAIRPTDLARRPEDVARYLDKDQLRLYELIWKRTLASQMAAAELDQVGVDIAGDQHGIVFRATGSVVVFDGFLKVYREDKDDSDDEDAEKLLPDVTEKDAMDRKAMRTEQHFTQPPPRFSEASLVKRMEELGIGRPSTYASILSVLQERNYVRLDQRRFIPEDRGRLVTAFLESFFGRYVEYNFTADLENQLDDVSGGRDDWRKVLDRFWRDFSGAVDETKDLRVAQVLDALDELLGPHFFPDNGTGHDPRSCPTCNAGRLSLKLGKFGAFIGCSAYPECRFTRPLTTGGEGEEEVREGPKELGNDPESGLPVTLRKGPYGHYVQLGDETTLKAEPAPVPEKGKKAPKTAKAVKAPKPKRVSLYKGLEPAGVTLDIACRLLALPRLVGTHPETGKSISAGVGRFGPYVVHDGVYKSLAKDDDVLVIGMNRAMELLSQAKGRGGSGPLKTLGEHEGKPVTLHEGRYGPYVSRDGVHATLPKDSSIETVTLEAALALIAAKAAKGPAKPVRGRKAAAPKAEAAPKPAAAKKAPAKKKAPTKKKVAAKG
(1246) DNA topoisomerase 1 [Chlamydia psittaci 6BC]
1
MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKEFGIDIEHDFEPDYQVLPDKQEVISQICKLASSCDIVYLSPDPDREGEAIAWHIANQLPENTHIQRISFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNVRVFLQDPKTSKTFWAHLYSADGKKWEKELPKGKTEDEILLINSETQAQHYVDLLEDASYRVTRVEAKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNNVRDYIHNTFGQEYLPKSPNVYTTKKMTQDAHEAIRPTDIHLSPDKLEGKLSDDQLKLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKLDDDTTEEENLSLPQLHAQDVLDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVITDIECSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVDTPWNSPCPVCGGEMKVRHGRFGTFLGCFNYPQCRGTISIHKKGEEVEQEEAIPCPAIGCSGKILKKRSRYNKTFYSCSEYPDCSVIGNTIDAVITKYTGTAKTPYEKKTTGKKKATTKSSSKTTKTTAKKKKSEGKTPKTPKAGALLTPSPQLALMIGPEPVGRGEATKKVWQYIKDHNLQSPENKKMLLPDEKFEAIIGPEPVDMFQLPKLLNQHLFKSD
(1247) DNA topoisomerase 1 [Chlamydia psittaci 6BC]
1
MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKEFGIDIEHDFEPDYQVLPDKQEVISQICKLASSCDIVYLSPDPDREGEAIAWHIANQLPENTHIQRISFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNVRVFLQDPKTSKTFWAHLYSADGKKWEKELPKGKTEDEILLINSETQAQHYVDLLEDASYRVTRVEAKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNNVRDYIHNTFGQEYLPKSPNVYTTKKMTQDAHEAIRPTDIHLSPDKLEGKLSDDQLKLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKLDDDTTEEENLSLPQLHAQDVLDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVITDIECSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVDTPWNSPCPVCGGEMKVRHGRFGTFLGCFNYPQCRGTISIHKKGEEVEQEEAIPCPAIGCSGKILKKRSRYNKTFYSCSEYPDCSVIGNTIDAVITKYTGTAKTPYEKKTTGKKKATTKSSSKTTKTTAKKKKSEGKTPKTPKAGALLTPSPQLALMIGPEPVGRGEATKKVWQYIKDHNLQSPENKKMLLPDEKFEAIIGPEPVDMFQLPKLLNQHLFKSD
(1249) DNA topoisomerase 1 [Chloroflexus aggregans DSM 9485]
1
MGEKVVIVESPAKARTIQKYLGKGYKVTSSMGHVRDLPKNGLAIDIEHDFAPSYEIVKPKVVSELNQAVRNADAIYLATDPDREGEAIAWHITQAVKTPKKTPIYRVVFQEITRNAVQQALQQPRQINQNLVDAQQARRVLDRLVGYQLSPLLWDKVKRGLSAGRVQSVAVRLIVEREREIENFKPQEYWTIEADLLKEAGIAPRDLFRATLIERDGKKLEKFSIERREQAEAIVADLQGAAYTVLKVTRRDKRRSPPPPFTTSTLQQEAARKLGFSAKKTMMLAQRLYEGVDIGGEEGMVGLITYMRTDSVQVAAEAQAEAREVIDRRFGREYLPDQPPVYKIKAKGAQEAHEAIRPTSSARTPEQLSERLERDLWRLYDLIWKRFIASQMAPAIFDSTTVDIAAQPSVAGAPPYLFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPPLVEGENLQLVELLPVQHFTEPPPRYTEASLVKELERLGIGRPSTYATILSTIQEREYVEMVDKKLIPTMLGRIVTDLLVEHFGNIVDYDFTSSLEQQLDDIAEGSKQWVPVLREFYGPFRSTLETAQRQMRNVKREEIITDLDCPKCGKGKLVIKFGRNGEFLACSRYNREGEGDSCDFTGDFHRDENGNIVLDQASAPETSDVLCNVCGRPMVIKKSRFGPFLGCSGYPECTNTRRIGRDGKPVPLPEPTGVTCPKCGEGELLRRRGKFGRPFYGCSRYPKCDYITNSLDEAQAGVAVEAAPALPPTVEKPAAPARKSSGKTRKSA
(1252) DNA topoisomerase 1 [Nitrosococcus halophilus Nc 4]
1
MSKNLVVVESPAKAKTIKKYLGKDFEVMASYGHVRDLMPKEGAVDPEHGFAMKYQVIEKNSRHVDAIAKALKKADALLLATDPDREGEAISWHLLELLKERGALEGKSIKRVVFYEITQQAVNEAIAHPRDISSDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIEAFKIQEYWTLEADAAASKHPFVAKLTHLDGHKLGQFDIDNGDRAQALVEQLTKAASGELLVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSTKRTMSVAQQLYEGVDIGDGAVGLITYMRTDSVNLANEAVKELRDFIAGHFGEKSLPAKPKTFKTRAKNAQEAHEAIRPTSVYRTPEELKPHLKPEQFKLYQLIWRRTIACQMNHATIETVAVDLDTRKSVPEKGVSNTGSNIFRATGSTVVDPGFMAVYQEGRDDTKAEEEQRILPPMKEGDRVELVRIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRSYALLENKRFHPTDVGRVVNRFLTEHFNPYVDYDFTARLEDQLDAISRGEKVWIPVLEEFWEPFLGRIQEKEQSVSREEAVQARELGIDPKSGRPVSVRIGRYGPYVQIGSKEDEEKPRFAGLRPGQKMDTITLEEGLALFELPRELGFSPEGEKVSVNIGRFGPYVKYDNKYVSLRGEDPYTIALERALELIQEKKQADANRVIKVFPDSGIQILNGRYGPYVTDGERNARVPKDQAPEKLSLEQAQTLINEAPAKRARRKTGTRKKAKG
(1254) DNA topoisomerase 1 [Anaerococcus prevotii DSM 20548]
1
MAKNLVIVESPTKARSISKMLGRNYKVMATVGHLRDLPKSKFGVDIENNFEPEYIKVRGRAKTINELKKEAKKAENVYLATDPDREGEAISWHLQFLLDLDPEAKNRVEFHEITKENVKNAIKNPRKIDQNLVDAQQARRVMDRIVGYEISPILWKRVKAGLSAGRVQSVALKLIVDKQKEIDDFVPEEYWTITAHHKEGREKFDSEFYGQINKKIKISNENGADKVLNKIDKDKFEVVKITKTKKRRKPQKPYTTSTLQQDASNRLGFSTRFTMQLAQQLFEGIDVGDGSVGLITYMRTDANRISKEIVGEALSYIKEKYGPEYAGKGNTYGGKKKGSQDAHEAIRPTSIRRNPLEIKEYLTDQQYKLYKMIWERVVASQMTDYEFLSTQVLFDNNSLIFKTNGKITLFEGFNKLGANKENENILPELKEGDVISAESIDKDQHFTKPPARYTEASLVKTLEEFGIGRPSTYSATINQIISRNYVELEGRSIFPTDLGKTVNTFLQENFDDVINVEFTREMEDALDNIAEGDRFWKETLKSFYKDFEKDMKGVKKDGKDYKVRDEILEEKCPKCGKPLAIKHGRNGKFIGCTGFPDCNFTKSIVKSTGVKCPECEDGTIIEKVSKRGKRFYGCDNYPKCDFALWDPPTGEKCPECGSLLIHKKNRSTDEIKCSSCDYVKEKRR
(1255) DNA topoisomerase 1 [Exiguobacterium sp. AT1b]
1
MAKYLVIVESPAKAKTIKRYLGPNYMVKASMGHVIDLPKSQLGVDVEHDFEPKYITIRGKGPVLKELKTAAKKATKIFLAADPDREGEAIAWHLARALGVDETTECRVVFNEITKDAIKESFKHPRKINHDLVDAQQARRILDRLVGYGMSPLLWKKVKKGLSAGRVQSVAVKMIIDREREINAFDPEEYWTIKLDLNHDGETFETSFYGKDGKKMELKSEEDAQSVLDTIDDTFKVIDVTRKERKRNASLPFTTSSLQQDAARKLNFRAKKTMMLAQQLYEGIDLGKKEGTVGLITYMRTDSTRISDLAKTEAKEYIESTFGEEYVALQKQKEKKSANTQDAHEAIRPTSALRDPASLKPYLSRDQLRLYKLIWERLIASQMAPAVLDTVKIDVESNGMIFRANGSTVKFPGFMKVYIESKDDDIEDTNQEKEGLLPPLEVDDTVTFETIEPKQHFTQPPPRYTEARLVRAMEELGIGRPSTYAPTLDTIQRRGYVVLEEKKFLPTELGELVIEMIDEYFNDFITVQFTADMETLLDSIEHKEVEWTEVVAPIYRSFEKRLKRAEEEIEKIEVKDEPAGIDCEVCGSPMVIKMGRYGKFMACSNFPNCTNTKPVQVEIGVPCPNCKDGQIVERRSKKGRLFYGCSNYPECEFVSWDKPVAKPCPVCDSLMVEKKIKDGVKYQCTNCTHTEVHQQEED
(1260) DNA topoisomerase like-protein [Arabidopsis thaliana]
1
MQRTISLAAAKSSSSTSVLSLHPLMAKLQCRAIQNFPASSSSSVVRVDRVYRNVSQLQFKRENSSCLKLACALPSHLSLLGSLSYATHWSSSTSRAFGYSFRPFARRYFSQVASTEIKDSIVGGVEKFGGNKIGFKKFNKKWKKHRVLASTKAEVVASTEPVIGDVNSGIKAKLSTAASPASNAKQASTVKTKRQPKSKKFEDKSSPTVSVLETVSVDESLQSFPKPRHSGSGNRKSSSAEYSSQKEVVKKTNVEGPKSSTPSNSMSEQQHWTSTKASNAPKQEQDNIVGGDEKAGGNKVGFKKFNKNRKKHNVLASSEAEVVTSTEPVIGDGSSGIKAELSTAASPASNGNQATTVKSKRRPKNKKVEDKSSSVVPVLEAVSLDESPISVPKPKHSGSGNRKSSSAKKEVAKNHPVEEPKSPAPSNSKSEQQHLKSTKASKAPKQKLVPQHMKNSIEHRGQNASKPLYPPSGKSVIVVESMTKAKIIQGYLGDMYEVLPSYGHIRDLATRAENLILASDPDREGEAIAWHIIEMLQQQGALHESMTVARVVFHEITESAIKSALQSPREIDGDLVHAYLARRALDYLIGFNISPLLWRKLPGCPSAGRVQSAALALVCDRESEIDGFKPQEYWTVGIKVKGKDNSATFSAHLTSLNSKRLNQLSISSEANAQDIEQRIKSEGFLVKGTKTSTTRKNPPTPYITSTLQQDAANKLHFSTAHTMKIADEAIKDIQSLVAERYGKNFTSDSPRKYFKKVKNAQEAHEAIRPTDIRRLPSTIASLLDADSLKLYTLIWSRAVACQMEPASIAQIQLDIGNASESIIFRSSCSKVEFLGYQAVYEDPEAKAIKNNDNDQSSEREETFKTLSSLKDGDLLQIGEVELKQHHTQHPPRYSEGSLVKKLEELGIGRPSTYASIFRVLQHRKYVTIKNRVLYPEFRARMVSAFLTHYFTEITDYSFTADMETELDNVSGGVTEWKGLLRDYWTRFSAYCKRVENVQRSQLYGRHLKFQSKFIAKTLYGEDEDEDDPPKNNCVEEPKLLGLHPNTSEKVILKCGPYGHYVQLGEDKKGHTPKRANAAHIKDVNSITLESALELLRYPLTLGTHPEDGQPVVLKLSKSGFTIKHRRNMATVPKNTEPGEVTLERAMKLLSGKNVRKSGRPPKSILPEEEKGDEEVVVAI
(1261) DNA topoisomerase like-protein [Arabidopsis thaliana]
1
MQRTISLAAAKSSSSTSVLSLHPLMAKLQCRAIQNFPASSSSSVVRVDRVYRNVSQLQFKRENSSCLKLACALPSHLSLLGSLSYATHWSSSTSRAFGYSFRPFARRYFSQVASTEIKDSIVGGVEKFGGNKIGFKKFNKKWKKHRVLASTKAEVVASTEPVIGDVNSGIKAKLSTAASPASNAKQASTVKTKRQPKSKKFEDKSSPTVSVLETVSVDESLQSFPKPRHSGSGNRKSSSAEYSSQKEVVKKTNVEGPKSSTPSNSMSEQQHWTSTKASNAPKQEQDNIVGGDEKAGGNKVGFKKFNKNRKKHNVLASSEAEVVTSTEPVIGDGSSGIKAELSTAASPASNGNQATTVKSKRRPKNKKVEDKSSSVVPVLEAVSLDESPISVPKPKHSGSGNRKSSSAKKEVAKNHPVEEPKSPAPSNSKSEQQHLKSTKASKAPKQKLVPQHMKNSIEHRGQNASKPLYPPSGKSVIVVESMTKAKIIQGYLGDMYEVLPSYGHIRDLATRAENLILASDPDREGEAIAWHIIEMLQQQGALHESMTVARVVFHEITESAIKSALQSPREIDGDLVHAYLARRALDYLIGFNISPLLWRKLPGCPSAGRVQSAALALVCDRESEIDGFKPQEYWTVGIKVKGKDNSATFSAHLTSLNSKRLNQLSISSEANAQDIEQRIKSEGFLVKGTKTSTTRKNPPTPYITSTLQQDAANKLHFSTAHTMKIADEAIKDIQSLVAERYGKNFTSDSPRKYFKKVKNAQEAHEAIRPTDIRRLPSTIASLLDADSLKLYTLIWSRAVACQMEPASIAQIQLDIGNASESIIFRSSCSKVEFLGYQAVYEDPEAKAIKNNDNDQSSEREETFKTLSSLKDGDLLQIGEVELKQHHTQHPPRYSEGSLVKKLEELGIGRPSTYASIFRVLQHRKYVTIKNRVLYPEFRARMVSAFLTHYFTEITDYSFTADMETELDNVSGGVTEWKGLLRDYWTRFSAYCKRVENVQRSQLYGRHLKFQSKFIAKTLYGEDEDEDDPPKNNCVEEPKLLGLHPNTSEKVILKCGPYGHYVQLGEDKKGHTPKRANAAHIKDVNSITLESALELLRYPLTLGTHPEDGQPVVLKLSKSGFTIKHRRNMATVPKNTEPGEVTLERAMKLLSGKNVRKSGRPPKSILPEEEKGDEEVVVAI
(1262) DNA topoisomerase 1 [Candidatus Desulforudis audaxviator MP104C]
1
MEKTLVIVESPAKARTLGKFLGKKYEIRASMGHVRDLPRSQFGVDVDDGFKPKYITIRGKGDAIKELRAARKKSNQVLLASDPDREGEAIAWHLQELLQIDPEEPCRVEFNEITREAVTAAIKNPRKIDPNRVDAQQARRILDRLVGYNLSPLLWRKVRKGLSAGRVQSVAVHLICAREREIEAFVSEEYWTLTALLANRERERFKARLLKKAGEKLTVPNEEAMKGILDDLKEEVYRVADVIRKEKKKNPSPPFTTSTLQQEAYRRLNFTTRKTMMVAQQLYEGLDLGKEGPVGLVTYIRTDSTRISPGAQDEAREYIAEHYGKEYVPKQKRVYTGKARAQDAHEAIRPTSVLRTPEALRKYLNPDQLRLYELIWSRFLASQMVSAVLDTVRAEIVAGEYLFRATGSTVKFPGFTRVYTELRDEAKNGEEEEEGALPALEKGEQLKLVRTTPARHFTQPPARYTEATLVRTLEELGIGRPSTYAPVVETIQRRGYVVRRGKTLHPTQLGLVVIDLLKEHFPDVINYEFTAELEEKLDRIEEGSMQWEKVLEEFYRPFRREVAEAEAKIDRVRLDEVTDEECRKCGRKMVIKMGRYGKFLACPGFPECRHTRPIFEETGHRCPKCGGRVVVRRTKKSKVFYGCAGYPGCDFVTWDQPTDQKCPDCQSFLVARGTRGHPLQRVSGSAGQSRTFACANPECGYKERKAGRGKA
(1266) DNA topoisomerase 1 [Rickettsia heilongjiangensis 054]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKAIIHAVENPRKLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTEKLKSQKFHVDKIEKKQQKRQPQPPFITASLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDKAEEENKMLPPLKEQEPLKTKKVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKPA
(1270) DNA topoisomerase 1 [Leuconostoc mesenteroides subsp. mesenteroides J18]
1
MAETKTATKKKKAAPRKKSKIKKNLVIVESPSKAKTIEKYLGRNYKVVASLGHIRDLPKSTLGVDVENDYDPKYINIRGKGDVIKGLRKEAKAAKAVYLASDPDREGEAIAWHLQHILDLNPEQPNRVVFNEITKDTIKNSFKTPRVINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIAREREIQAFQPEEYWTLDSMFKKNRTKFKSIFYGFDGKKQPLPDNDSVQDVLKRINKDGDFDIVKVDTKQRKRQPQPPFTTSTMQQTANTQLKFRTRKTMMAAQQLYEGINLGKGLGQVGLITYMRTDSTRISSVAKNAAAQFIHDTWGEEYSQHKPVQGKLQEGAQDAHEAIRPSDVNRTPESIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNGVIFRANGSKTNFEGFTKAYPTAKKKDNVLPSLSEGDKVSLANTDPEQHFTLPPARYSEATLIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVEESFPDVTNMKFTAAVEHELDEVETGNKHWVPVIDSFFKPFQKEVEKAETSLEKIIMHDELAGMDCEVCGAPMLVKMGRYGKFYACARFPDCRNTKAIVQEIGLLCPKCHKGQIVQRKTKRGRTFYGCQRYPDCDFVTWDKPTEKTLADGTTPKDDEKKEPVKK
(1274) DNA topoisomerase 1 [Sphaerochaeta globosa str. Buddy]
1
MDNANTLIIVESPTKAKTITKFLPSSCKVVASKGHIRDLPEDRMAIDVEHEFACDYEVVSGKESLIKELKSSLKKADRLLLATDEDREGESISWHLLEVLKPKIPFQRMVFHEITKSAITKALEGGRPLDENLVKAQEGRRIIDRLYGYTLSPTLWKKLSNKKLSAGRVQSVGLRLTVQRERERLAFQQSTYFDAKAELLAEQKQHFEAKLTAYQGHRLANSKDFDSISGQYKAKGQVLQLSREQAQAIVKELKAEPFRVQDIQRKPFVTRPNIPFTTSTLQQDAIKKLHISASDTMRIAQKLYENGFITYMRTDSPSLSQEGTQAARSQVDQLYGQEYLSPSARYFAAKSAGAQEAHEAIRPAGERFLIPSETHLIGKELALYELIWKRTLASQMAEAKKATTTVTLEAGEGTFTATGTEIVFPGFLRAYVEGSDDPDAALEDKETLLPAMKVGQVCPLASLVEVEHQTKSPARYTEAYLVQELEKRGIGRPSTYATIIKTLLDRRYAIKEGSALAPTFIGFAVCQFLETNFPQFVDYDFTSMMEDGLDKIASGELDKIVFLSSFYCGESGLLSQNALQLKQDNKVVSKTLILPHISDKNPVMIGPYGAYVIDANEAFISLPLSWIPGNITDEDVKTLIANGKEKQQPVTLGSGAVKGEAVKVMNGRFGPYWQEGEGKDAKRASIPKWVQDANRSEELELANRYLSLPRNLGKDEDGNEVLAYKGKYGPYIASNNKTRNLKKTDHDQELFSITLKEALALLSQEVEKSGAKGKKGGARSAKASTVKDLGQFEGEAVSVATGRYGFYLKAGKENIALPDAYKKDEEKALSLTLDEAVEHIRTKRAKE
(1276) DNA topoisomerase 1 [Clostridium botulinum A str. ATCC 19397]
1
MGQKMGQNLVIVESPAKAKTIKKYLGKNYVVEASMGHVRDLPKSQLGVDIENNYDPKYITIRGKGELLDKLRKEAKKSSKVYLATDPDREGEAISWHLAHVLKIDESEECRIEFNEITKTSIKKAIKSPRRINENVVDAQQARRVLDRLVGYKISPILWSKIKWGLSAGRVQSVALRMICDREREIEEFIPKEYWTIECEVYKEKNKKPFIIKLTTKSGKKIEINNEEEAIEAIQDLKKGEFIVKKIKKTKKNKNPLAPFTTSTLQQDSYKKLNFSTKKTMSIAQQLYEGIDIKGFGAVGLITYMRTDSIRISEEAQKSTLEHIKSNFGEEYIPKTPRVFKGKKNIQDAHEAIRPTNIEITPTLAKESLTPQQYKLYELIWKRFVASQMASCILDSTSISIENGKYGLRASGSLIAFDGFMKVYEYSTEEEKDSIKIPELEDNEILGEKSINKSQHFTQPPARYSEASLVKTLEENGIGRPSTYAPIISTILDRKYVEREKKTLKPTELGDIVNNILSEYFKQIVDLEFTADMENKLDYIEEGKKSWREVVNDFFQPLIESIEIAEKEIAKITIEDKVTDVVCEKCGRNMVIKHGRYGDFLACPGYPDCKNTKPIVEEIDVKCPKCRDGKVLIKKSRKGRKFYGCSNYPDCDFVSWSEPVKEKCEECGSYMVKKQSKAKGEYYECANSECKHRKYLNNKE
(1277) DNA topoisomerase 1 [Caulobacter segnis ATCC 21756]
1
MNVVVVESPAKAKTINKYLGSDYTVLASYGHIRDLPSKDGSVEPDNDFAMSWEVDAKASKRVSDIVDALKKADRLILATDPDREGEAISWHVLEVLNKKKALKDKSVQRVTFNAITKTAVTEAMKAPRDLDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVVDREIEIERFKTQEYWTVEADVSAGSDPFLARLVKHEGKKLTKFDLGNETSALAAKAAVQAAVFKVEAVEKKPGKRSPAPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVSMAPEAITEARDVIGKVYGKEYVPDVPRLYKSKAKNAQEAHEAIRPTSMGRNPGSLRLDPELGRLYELIWKRTIASQMESARIERTTVDLESADGKTGLRATGQVVQFPGYLAVYEEGRDDEGDEDSARLPAIVEGSPAQVREARADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASVLGVLRDREYVRMEKQRFIPEDKGRLVTAFLEQFFKRYVEYDFTAALEEQLDLVSDGKLDWKQFLRDFWKDFHAAVGEIAELRTTNVLDALNEALGPHIFPDKGDGSNPRLCPTCGTGQLSLKTGKFGAFIGCSNYPECRYTRQLGVSEGDGEAESADKELGVNPATGRAVWLKNGRFGPYVEELAAEGDKPKRSSLPKGWIASAIDLEKALRLLSLPREVGKHPDDGKVITAGLGRFGPFVLHDGTYANLENADEVFDVGLNRAVAILADKRAGGGRPQRGAAAALAELGNHPEDGKPIRVLSGRFGPYIKHGDTNANVPKGKDPAAITLEEALALIAERAAKGGGKKPAKKAAASKAKAPTKAEGDKPAKKTAAKKPAAKKTAPKAKAKAPAASDDGAAPWDDEA
(1286) DNA topoisomerase 1 [Ruminococcus bromii L2-63]
1
MSDLVIVESPAKAKTIKKYLGSGYEVVASMGHVRDLPKSRLSVDIKKNFAPKYEIIKGKEKLVDDLKSAAEKSEHIYLATDPDREGEAISWHLAYILGLPTDETNRVEFNEITKSGVTNGMSNPRSINIDLVNAQQARRILDRLVGYKLSPFISQKIRRGLSAGRVQSVAVRIIVDREEEIRKFKPEEYWSIDAKFIPKGSRKSFSASLYSDENGKIKITNGEQADKIEADLQNAEYVITKVKNGTRKKSPAPPFITSTLQQEASRKLGFQSRRTMKVAQELYEGVDIEGMGATGLITYMRTDSLRISNVAIEEVTEYIKNSYGEKFLPPKPRFFKSRSNAQDGHEAIRPSMPSLTPDSVKASLTSDQYKLYKLIWNRFTASQMADCIQKTTQADIVANGYTFKASGYRVDFEGFTTLYVESKDVEEEKTTQLPPLEKDMIVRCKELKKNQHFTQPPARYTEASLIKALEEYGIGRPSTYAATITTITSHEYVKREGKSLVPTELGEVTTNLMKERFPKIVNVKFTNQMEEDLDKVEKGTEEWHALLDNFYGDFDKTLKKAKADMEGVKLHLKEDETDIICDKCGRQMVVKVGRYGKFIACPGYPECKNIIKYVEKTGVKCPKCGGDVIIKRTKTKRIFYGCSNYPECDFVSWNEPTNEKCPQCGGILFKKKGKKPTLFCATEGCGYTKTADTDDK
(1288) DNA topoisomerase 1 [Moorella thermoacetica ATCC 39073]
1
MLAKTLVIVESPAKAKTIGKFLGKNYTIKPSMGHVRDLPKSQFGVDVENNFEPRYITIRGKGEIVKELRAAAQKAQRVLLAPDPDREGEAIAWHLQHLLGLPDEAIRIEFNEITRNAIQEAVKKPRKIDQDRVDAQQARRILDRVVGYRLSPLLWRKVRKGLSAGRVQSVAVRLIVDREQEIEAFQPEEYWSLTAWLLPENEGEAFPARLVKYAGEDLNVKNEGEMESILHSLEGTTYVVAEVKQRERRKNPAAPFTTSTLQQEAYRKLNFTSRRTMQVAQQLYEGIDLGGGQGPVGLITYIRTDSTRVASVAQLEARDFLMERFGSEYVPEGLRQYKGRKDIQDAHEAIRPTSVWREPASLKNILTRDQFRLYNLIWERFVASQMQAAVMDTVTVDITAGPCLFRATGSVVKFPGFLKVYQEGRDGEDKDQEQRLPPLATGQTLKLQSLEPKQHFTQPPPRYTEATLVKTMEELGIGRPSTYAPTIETILQRGYVTREQKQFVPTELGRVVVALLKEHFPKIIDVEFTAHMEEQLDAIEAGKISWRQVLAEFYGPFEEVLEKAEAEIGTVEVPEEVSEEKCELCGRNLVVKMGRYGKFLACPGFPECRFTKPLLETIGVNCPECGGQIVARRTKRGRKFYGCQNYPRCTYVSWDKPTNQTCPRCGKRLVEKASRQGSRLVCPQKECGYVEEVRQAK
(1289) DNA topoisomerase 1 [Stigmatella aurantiaca DW4/3-1]
1
MATRKKKADETGTEAEETAAKKKAKRPAAKKAAAKKKSATKRKGSASLATVEVSADEEEEATPRGKGPHYLVVVESPAKAKTIKKYLGTGYTVKASVGHVKDLPKSKIGVDVEHDFQPEYQVIKGKEKVLNELKKAAKAVDKVYLATDPDREGEAIAWHIFEELGHKDSYRVLFNEITKKAIQEAIAQPRHLNQESYDSQQTRRILDRLVGYQISPLLWKKIRRGLSAGRVQSVAVRLICEREDEIKAFLPQEYWTLDALLEGASGPPPFKAKLSKIDGKKVELKDRETTDALVAELQGAEFTVAKVDRRERRRNAPAPFITSKLQQEAANRLHFTAKKTMTLAQRLYEGIPMGEEGQTALITYMRTDSTRLSDDAVKQVREFIGNQYGGDFLPEEPVSYRSKKNAQDAHEAIRPVSLEYPPERVRPFFEQMGEQDMFRLYELIWNRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLRVYGAGLTPEEEAEKEKAKAAGDEATDSDEATGELPPLNDGDKLRLQKLLNEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGVMTNEMLVKHFPKEMAVAFTADLEEKLDQISEGGASWKAVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNPLVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVIVEEETTDEKCENCGKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVNCPECKQGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEACPQCQSPYLLQKFSKRDGVYVACPNKECDYRREVQQPADATAPSAA
(1295) DNA topoisomerase 1 [Cellulophaga algicola DSM 14237]
1
MAKNLVIVESPAKAKTIEKFLGKDFKVESSFGHIADLPSKELGVDVENDFEAKYIVSKDKEALVKKLKDLAKKADTIWLASDEDREGEAISWHLEQELKLDKSKTKRIVFNSITKSAIQKAIENPREINYDLVNAQQARRVLDRLVGYELSPVLWKKIKPGLSAGRVQSVAVRLIVERERDIEGFTPEASFKITAQFKTNEGSIFSAKLNKTFATKEEAEAFLKENMKGKFAVASLDKKPAKKSPAAPFTTSTLQQEASRKLYFSVGRTMQVAQRLYEAGLITYMRTDSVNLSKEALDEAKAAIVENYGKEYSNSRNFKGKSKGAQEAHEAIRPTDMKLQNVSLERDQEKLYELIWKRTLASQMSDAQLERTNVKISCSGHNQEFTANGEVIKFDGFLKVYMEDVDDEDAAEEQEGMLPAMKKGEALTNNYITATERFSRPPYRFTEASLVKKLEELGIGRPSTYAPTISTVQNRGYVEKGTIEGVERKYVQLVLENNAVATNDLTENVGSDKGKLVPTDIGMIVTDFLVSHFSGIMEYNFTAKVEEDFDEIAEGKEDWKKVMKNFYKDFHPKVIDVEENADRASGERILGTDPKSGRQVLVRLGRFGPMVQIGSSEEEEKPVFASLLPEQSLNTITFDEAMELFTLPRTLGEYKGEEVLANVGRFGPYVKFGEKFISLDKGESAFDVVFERAVELIIAKEKADAPVAHYEDKEVTKGTGRFGPFIKWDGMFINVNKKYDFDNLTNDDIIELIETKKQKEIDKVIHDWKEEGIRVEKARWGRHNVLKGKIKVELSKEVDATKITLEEAQAMIEKKTPKKKAKAAPKKKAAPKKKAAPKKKAK
(1297) DNA topoisomerase 1 [Rickettsia canadensis str. McKiel]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAIKYDISDKASKYVDAIVKDAQKADAVYLATDPDREGESISWHVAEVIKEKNKVKAADFFKRVAFNEITQKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKAEEYWDISLKMQNSNNELFTAKLTHINNQKLERFSITNKKDAKDLTKKLKSQNFHIDQIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVADIRKLIDKNYGDKYLPSSPRIYKSTVKNAQEAHEAIRPTNITYTPDSLKEKLAKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESVDDEAEEENKMLPLLKENEQLNTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYATILSVLQDRKYVSLKKKRFMPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKSALSNFWSGFNHNIKSVNEQKITEIISYVQKALDYHLFGENQESKACPSCKTGELSLKLGKFGAFLACNNYPKCTFRKSIVSGNNNNENEDKLSTTPNEENKVLGTDKDGIEIYLKKGPYGPYIQRGEHEGTVKLKRSPVPASLNQSDITLDIALKLLSLPLKIGTHKDTHEEIMIGYGKFGPYIKYIGKFISIPKKYDFLNLSLDEAIQLIEDNKTKLEKKQA
(1299) DNA topoisomerase 1 [Geobacillus thermoleovorans CCB_US3_UF5]
1
MSDYLVIVESPTKAKTIERYLGKKYTVKASMGHVRDLPKSQMGVDIDHGYEPKYITIRGKGQVIKELKTAAKKAKKVFLAADPDREGEAIAWHLAHMLDLDIHSDCRVVFHEITKDAIQQSFQQPRAINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREREIREFQPEEYWTIQATFQKEGETFAASFYSIDGQKRDLKTEADVKAVLDRLNGTAFAVKTVTKRERKRSPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVAETAQQEAAAYIEATFGAMYVNQEKRKEKKSTNAQDAHEAIRPTSAFRDPDKVKPYLTRDQFRLYKLIWERFIASQMAAAVLDTMSVELENNGVVFRASGSKVKFPGFMKVYIEGTDDQTEEQDRILPDLEEEETVESETIESKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVVELMLEFFPEIIDVEFTAKMEKELDEIEEGKVEWIKVVDEFYREFEKRLKVAEKEMRAVEIKDEPAGIDCEVCGSPMVYKMGRFGKFIACSNFPECRHTKPIVKEIGVKCPKCREGNIVERSTKRKRVFYGCDRFPDCDFVSWDKPLARPCPKCAGLLVEKVLKKGVQVQCTACDYEERLEA
(1306) DNA topoisomerase 1 [Caldicellulosiruptor obsidiansis OB47]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAEAAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATKLVVEKEEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQIQEIEEKIKNKEFKVVKLKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARKLIAQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMNPESIKDSLTPEQYKLYKLIYDRFLASQMESSIYDVLSAELEVEGYVFRLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEISEGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKIEWTEVVRKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKKVIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPKCGSLMFEKGRKGNKKLVCSNENCLYEEKMGEKGE
(1308) DNA topoisomerase 1 [Streptococcus gallolyticus UCN34]
1
MATTTTTKAPTAVKKSSKKTTKKKTAAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINDLKKEAKKSKKVYLASDPDREGEAISWHLAHILDLDENDKNRVVFNEITKDAVKNAFVEPRQIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGFFKKGTKKFQASFYGIDGKKLKLETNEDVQKVLALLTSDEFTVAKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGISLGKSGTQGLITYMRTDSTRISPIAQNDAANFITERFGEKYSKHGSRVKNASGAQDAHEAIRPSNVNLTPESIAKHLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVNLELNSVRFTANGSQVKFDGYLAVYNDSDKNKMLPDMVEGDIVKKVSTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVRLAAKRFEPTELGEIVNNLIVEFFPDIVDVKFTADMEGKLDEVEEGKQQWQKVIDEFYKPFEKELAKAETEIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVTCPVCGKGQVIERKTKRNRIFYGCDRYPECEFTSWDKPVGRSCPKSGDFLVEKKIRGGGKQVVCSNEECDYEEAKIK
(1309) DNA topoisomerase 1 [Bartonella clarridgeiae 73]
1
MNIVIVESPAKAKTINKYLGSQYKVIASFGHVRDLSAKDGSVLPDKDFAMKWDIDTASAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDILKQKKVLNNKPIKRVVFNAITKKSVLAAMKNPRDIDISLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICNRESEIEQFIKEDYWSITTYLKTLQDNIFYARLTEFNHKKLGKLDIRSQEQADQIFFMLEKANYRTLSIEAKPIKKNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVEINGETAGLITYMRTDGVQMASEAIDAARKAIIDSFGNHYVPEKPRFYSTKAKNAQEAHEAIRPTDFKRHPNQICNVLDSDQAKLYELIWKRAIASQMRSAEIERTTVEIEAFQEENHANLRAIGSVIHFDGFISAYTDPKEEENSEEDESTRLPQINIGESLKKEKVELTQHTTEPPPRYSESALIKKLEELGIGRPSTYASTLSTLCDRGYIITDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTANLEEKLDLISDGKLSWKDVLHDFWDEFNASITSIQELRIMNVLDVLNVTLAPLAFPTREDGSDCRSCPLCINGQLSLKLGRYGAFVGCSNYPECKYTCQLGTDTKEKSKVVHNDEPIMLGIDPETGKDISLRNGRFGPYIQLGEDKKSKRASLPKGWQIENINFDKALALLSLPREVGTHPETGKIITAAIGRYGPYLAHDGKYANLFSIDEVFDIGINRAITILAEKKNNETNRRRILPTVLTTLGDHPEGGTITIRDGRYGPYVNWNKINATLPRDKDPTTVTLSEALELISAKASTKKTGQKATSKKKLTPKKASPRKEKA
(1310) DNA topoisomerase 1 [Prevotella melaninogenica ATCC 25845]
1
MQENLVIVESPAKAKTIEKFLGKDYKVMSSYGHIRDLKKKELSIDLDTLNPDYEIPDEKKKVVSELKKSAKAADKVWLASDEDREGEAISWHLCEVLGLDEDKTNRIVFHEITKPAILKAIESPRRLDMNLVNAQQARRVLDRLVGFRLSPVLWRKVKPALSAGRVQSVAVRLIVEREREIQNFNSEPYYRLNAVFAVTSEDGSKNEVKAELSKRFKTHEEALAFLELCKTSKFKVSSIAKKPLKRTPAPPFTTSTLQQEAARKLGFTVSQTMMVAQRLYEAGRITYMRTDSVNLSALAIEGCKTEIERLYGEDYGKVRKYQTHSKGAQEAHEAIRPTYIDNVSIEGTSQEKRLYDLIWKRTIASQMADAKIEKTTVNISLESEEGKNTTDLQFIANGEVVAFEGFLKVYHESTDDDENSEEFSHALPVMHEGEELERREIVSTERYSQGPNRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVQKGDRKGEERKYAVDSLLGLKITSKTKKEMAGADKGKLIPTDIGIVVNDFLMGNFPDIMDYNFTAKIEQEFDKIAEGKAEWNKEMKTFYQSFEPEVEKVMNARSEHKAGERELGLDPATGKPVFVKIGRFGPVVQIGSADDEDKPRFSQLPSDKSMEAITLDEALELFKLPRNLGQFEGTDVVIGAGRFGPYVLHDKKYTSLPKEEDPLTISLDAAINLIQKKRLQDAQRHLKTFEEDAKMEVMNGRYGPYIAYDGKNYRMPKNLHDKAAELTYEQCMDIVKNAPEPKRKK
(1312) DNA topoisomerase 1 [Bacteroides vulgatus ATCC 8482]
1
MQKNLVIVESPAKAKTIEKFLGNDYKVLSSYGHIRDLKKKEFSIDVENGFEPTYEIPADKKKLVAELKAEAKKADMVWLASDEDREGEAISWHLFEVLGLDPEKTKRIVFHEITKTAILKAIENPRDIDVNLVNAQQARRILDRIVGFELSPVLWKKVKPALSAGRVQSVAVRLIVEREREVHAFVSEPSYRVTAVFEVPDVDGNEVEVKAELSNRFKTKEEAQAFLETCKDAQFSIEDITTRPVKKSPAAPFTTSTLQQEAARKLGFTVAQTMMVAQRLYENGQITYMRTDSVNLSDLALNTSKQTILSLMGERYVKVRKFATKTKGAQEAHEAIRPTYMENETVNGTGQEQKLYELIWKRTIASQMADAELEKTTATIVISNSSEKFIATGEVITFDGFLRVYKESYDDDNEQEDEGRLLPPLSKGEKLIRKEILATQRFTQCPPRYTEASLVRKLEELGIGRPSTYAPTISTVQQRGYVEKGNSEGVKRPYDILKLKGGKITETTKTEMTGNEKAKLLPTDTGIVVNDFLMEYFPEIMDFNFTANVEKEFDEVAEGEKEWTGMMDSFYKGFHPLVDKTIHSKTEHKVGERVLGTDPVSGKPVSVKIGRFGPVIQIGTADDEEKPRFAQLAKGLSMETITLEEALDAFKLPRTLGDYDGHTVTVGVGRFGPYVRYDKLFVSIPKGTDPMEISLDEAVELIKNKIEAQEKKFIKVFDADPDMQVLNGRYGPYISYQKKNYKIPENVEPADLSLEACFKVIELQKSKAETRKTKAASRNRGTVNMEEESEKPEESAKSKAASKVKGTAKAKK
(1318) DNA topoisomerase 1 [Xanthomonas oryzae pv. oryzae KACC 10331]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNSFAMRYDLIEKNEKHVEAIARAAKGADDIFLATDPDREGEAISWHIAEILKERGLLKDKPMQRVVFTEITPRAIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIDAHCRHPSQAFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALSEIRDVIARDYGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVPGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTAKLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGTDPVSGKEVSARIGRFGPMVQIGSVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKDFEGSDIQVLNGRFGPYISDGKLNGKIPRDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVKDSAPKKPAAKKTATKTAASKTAAKKAPAKKAAAEKGTKRVVKKTVSKAAD
(1319) DNA topoisomerase 1 [Nostoc punctiforme PCC 73102]
1
MSTLVIVESPTKARTIRNYLPAGYRVEASMGHVRDLPQSASEIPAAVKGETWAQLGVNVDADFEPVYVVPKDKKKIVTQLKEALKDVDELILATDEDREGESISWHLYQLLKPKVPTKRMVFHEITQEAIKKALKDCRQIDEQLVRAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVTRERQRRAFHEGTYWDLKASLSKEKTPFAAQLVTLAGTKIANGSDFDATTGQITAGRNVLLLNEDQAVALKERLTGKTWSVTEMEERPVTRKPSPPFTTSTLQQESNRKLRLSARDTMRVAQNLYEQGYITYMRTDSVHLSDQAIAAARSSVEKLYGQQYLSPQPRQYTTKSKGAQEAHEAIRPAGSTFRTPQETGLGGRELAVYDLIWKRTVACQMADSCQTQISVQLQVEDAGFRSSGKRIEFPGYLRAYVEGSDDPEAALEDQEVILPNLKVGDHPNCTDLEAVGHETQPPARYTEASLVKTLESEGIGRPSTYASIIGTIIDKGYAHLVSNALIPTFTAFAVTDLLEKHFPDIVDPSFTSKMEQTLDDIATGEAKWLPYLQKFYLGEKGLETLVKERESQIDATTARTVELENLDAKVRIGKYGPYIEVTNGEGVITASIPKDLTPADLDPKQVEVLLRQKITGPDQVGRHPETGEPIYVKIGAYGPYVQLGDKTDENPKPKQASLLKGVTPETVTLEMAVGLLALPRTLGVHPVTGGKIQASLGRFGPYVVHDQGKEGKDYRSLKAADNVLTISLERALELLSEPKKGRSSTNSKSKAALRELGPHPEDGETINIYDGPYGPYIKHGKTNVSIPEGQTVEDITLTEALNLLAAKASTAKSTRKTTKSTNSKSKSTGKSTAKSTTAAKKKVTEG
(1321) DNA topoisomerase 1 [Staphylococcus lugdunensis HKU09-01]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDVDDNFEPKYITIRGKGPVVKELKKHAKKAKKVFLASDPDREGEAIAWHLSNILELEDSKENRVVFNEITKDAVKESFKHPRDIEMDLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYQKSKFTAKFLHYKNKPFKLQNKDDVNKITAKLDGDQFEITNVNKKEKTRNPAQPFTTSTLQQEAARKLNFKARKTMMIAQQLYEGIDLKRQGTVGLITYMRTDSTRISDAAKNEAKSYITENYGSNYVSKRQAKGKQGDQDAHEAIRPTSAMRTPNEMKSYLSRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNDIKFRANGQTIKFKGFMTLYVEAKDDKENDKENKLPNLKEGDKVTATQIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLDSKRFVPTELGEIVYEQVKEYFPEIIDVEFTVNMETLLDKIAEGDMKWRKVIDDFYNSFKLDVARAEKEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPTCKKGDVVERKSKKNRIFYGCSNYPECDFISWDKPIGRDCPKCEHYLVEKKKGRSSQVVCSNCDYQEEAQK
(1323) DNA topoisomerase 1 [Chitinophaga pinensis DSM 2588]
1
MAKNLVIVESPAKAKTIEKILGKDFEVKSCFGHIRDLEKDDMGIDIANNFKPKYTIPDDKEKIVKELKKLAKDTDEVWLATDEDREGEAISWHLCEVLGLDPDVTKRIVFHEITKPAIERAVQQPRLLDMNLVNAQQARRILDRIVGFELSPVLWRKMSMRNSLSAGRVQSVAVRLIVEREREINTFNAVSSFKVEAFFTAKDLQGKNITFKAEGPTRFKTAEDAEKFLQQCIGAAYSVKDIQVKPGKKSPAAPFTTSTLQQEASRKLGYSVSKTMLLAQKLYESGKITYMRTDSVNLSDTALGDIQNAITTNYGQRYHQHRKFKNKNESAQEAHEAIRPTYMENATVDDSDTKKLYELIWKRTIASQMSDAELEKTIAKIDISTNHEELTASGEVLKFDGFLKIYMEGKDDEDVSDEEESDGSLPALTVKQALDLKEMKATERYSRPAPRYTEASLVKKLEELGIGRPSTYAPTITTVQKRGYVEKRDKEGIKRDFRILSLKADKITKVTESENTGAEKSKLFPTDLGMIVTDFLNQYFSSVMDYGFTAKIEGEFDEVAHGKKIWNKMLNDFYTPFHKDVENTLEKAERVKGERQLGTDQETGKPIVARMGRYGPMIQIGKAEDEEKPKFAKMKSTQSIETITLEEAMELFRLPRNLGQFEDQDVLVNIGRFGPYAAHNKQFYSLKKEMDPYTVELDEIAPLIVEKRTAKDERTIKIFEKEKIQILKGPYGPYIKQGLRNYKIPKEKIDAAADITLEEAKAIIEDVKANPPKKKAPPRKKKAE
(1328) DNA topoisomerase 1 [Clostridium ljungdahlii DSM 13528]
1
MGQKLVIVESPAKAKTIGKYLGKNYVVKASMGHVRDLPKSQLGVDIDNEYTPKYITIRGKGELLDKLRKEAKKSEKVYLATDPDREGEAISWHLSHALKLDENEKCRIEFHEITKNAVKSSIKSARLININLVNAQQARRVLDRLVGYKISPILWRKIKWGLSAGRVQSVALKMICEREKKIVDFVPQEYWTIECELHKENESKCFNVKLTTFNKKKIEIGSKDEVDKIIEELKQGQFIVKSIKNTNKNRTPLPPFTTSTLQQDAYKKLNFSTKRTMSIAQQIYEGVDIKGYGTIGLITYMRTDSVRIAQEAQEACRDFVANKFGKEYIEEKPRNFKSKKNIQDAHEAIRPTNVEITPEIAKENLKPEQYKLYNLIWNRFVASQMSSCQIDVKSIDIVNSNYGLKVSGSRIKFDGFMKVYKYATEEEKSDISLPKLEEGEKLLRKSIDGKQHFTQPPARFSEASLVKTLEENGIGRPSTYAPILSTLLDRKYIQREKKTLIPTELGDIVNNIVSQYFKQVVDVEFTAAMESKLDSVEDGKDDWRKVVGEFYEPLKKSIEIAEKEVARITIEDKVTDIKCDKCGRNMVIKHGRFGDFLACPGYPECKNTKPIVEELDVKCPKCQGKVLIKRSRKGRKFYGCSNYPDCDFVSWFEPTNEKCKECGNYMVKKYNKSKGNYLECSNSECKHREYKAVEDGDEKTAK
(1331) DNA topoisomerase 1 [Acetohalobium arabaticum DSM 5501]
1
MAENLVIVESPAKAKTINKFLGKGFNVEASMGHVIDLPKSQLGINIEENFEPKYITIRGKGDVLKKLRKAVKKSDNVFLATDPDREGEAISWHLSRALKLDDESECRIEFNEITENAIQQAIEAPRSIDKDRVDAQQARRLLDRLVGYKLSPLLWKKVRRGLSAGRVQSVAVKIICQREEEIEEFEPDEYWSLEADLQTDSKQQFEAKLHRIDGDKFKLNNKEETDKVIVEAEKNNFVIEKIKERKRRNNPAPPLTTSSLQQRAASSLNFTAKKTMFIAQQLYEGLDLGSEGTVGLITYIRTDSTRISKEAQQDTRKFIEDNFGPRYRPKDTKKYKVKSGAQDAHEAIRPTSVFRTPKKVKSYLNNDQYRLYKLIWEKFVASQMTPAIYKTLSVDIKAGKYLFRSTGSRTLFKGYLAVDTFKNRKQDKDLPEDLEEGTEVELLEFKPEQHFTKPPARYTEAKLVKTLEKKGIGRPSTYAPTVAKIQDRGYVNKEGKRFVPTELGKTVNHLLNKHFPDVTDIKFTANLEQQLDDVEVGKEDWRELLKEFYFPFEERLNSAYENMEEVELEKEVTDEVCEKCGKNMIVKHGKYGKFLACPGFPDCKNTKPYLIKMGVDCIECEDGEVVQRKSKKGRTFYGCSNYPDCEFMIWYKPVQEYCPECGTFLMEKTTKKRGTEYLCADEDCDFKTTPEELESEE
(1338) DNA topoisomerase 1 [Geobacter sp. M18]
1
MSQNLVIVESPAKAKTIEKFLGPEYKVLASFGHVRALPSKQGSVDVEHEFEPKYAVLPESKKHIDAIKKEMKGITSLLLATDPDREGEAISWHLLAALGLDGKKKASFDIKRVVFHEITKDAIVHAVQHPRGISVDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIGAKLETAKKQALTAALVEAEGKKLSKFDIPNQEAAFRLFGLLGGKEFPKQEGEEGSAPLVVKAPVNPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEDARQLITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYISKTPIEVKKFLTSDQFKLYDLIWKRTVACQMAEALLDQTSVEITAGEGFRFRVAGTVIRFAGFMKLYIEGVDDEAEDKEKEGMLPPLKEGDILKLQQLLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFNQYVDYNFTANLEEQLDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVSKSDLTTEATDEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEELCDKCGSHMLVKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCTACGKGELIEKKSRFGKLFYSCNRYPECKFALWDQPVQKPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYQSNKE
(1339) DNA topoisomerase 1 [Gluconacetobacter diazotrophicus PAl 5]
1
MTDVVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDENFAMDWQADERGSRQMAAIAKALRGARHLYLATDPDREGEAISWHVRAMLEEKNLLKGVDVQRVTFNEITKSAIRAAMAQPRDLDQPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIESFRAREYWTVAAQFTTPGGAAFTARLTHLAGCKLDQFDLHDEAGAMAAKAAVEAGRFAVQSVERRKVRRNPPPPFTTSTMQQEASRKLGMGAQGTMRTAQQLYEGIDLGGETVGLITYMRTDGVQMAGEAIAAIRGHIGESFGAPYVPEKARIYSTKAKNAQEAHEAIRPTDVSRTPAQMARYLNDEQRRLYELIWKRSVASQMQSAELDQVIVEIADAGGAATLRATGSMIAFDGFLKLYSEGRDDAAPKDEQDDDSRMLPPMRERDALKTGEVAADQHFTQPPPRFSEASLVKKMEEIGIGRPSTYASILTVLRDRNYVRLDARRFVPEDRGRLVTAFLTSFFERYVDTQFTAGLEEQLDDISGGRADWRDVMSAFWQDFSRAVDQTKDLKISDVISALDADLAPHFFPAHPDGSDPRVCTACGTGRLGLKLGRYGAFIGCSNYPTCQFTRRLVVDPKEDGEADTLKDGMRLLGQTPGGEDVTVRRGPWGLYVQQGEPDPEDKKAKPRRATIPRGIEGDKITLDQALGLLSLPRVVGIHPETGEQIEAGLGRFGPYVKMGAVYGSLDKDDDILTVGLNRAVDVLARKLASVRTIAPHPKDGEPVIVRKGRFGPYIQHGTMVVNVPRGEAMEDVTLDQAVALLAEKGKPLKPKGKAAAKKAPARKTAARKAPAKTAAKKAAPDGDADTQARAAKPPARKAAARKTPAGKATGKTAKGKAEPGEGAGPRTRRTATEAG
(1340) DNA topoisomerase 1 [Caldicellulosiruptor kristjanssonii I77R1B]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEILKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGNLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(1342) DNA topoisomerase 1 [Geobacillus thermoglucosidasius C56-YS93]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDINNGYEPKYITIRGKGQIIKELKTAAKKAKKVFLAADPDREGEAIAWHLANMLELDIHSDCRVVFNEITKDAIKESFQHPRAIDMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIKQFQPEEYWTIQAEFVKGNETFTASFYGADGQKLDLKNEADVSAILRRINGNHFTVTSVAKKERKRNPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVSESAQQEALSYIEATFGKEFAAQEKRKEKKSANAQDAHEAIRPTSVFRDPEKVKPYLTRDQFRLYKLIWERFVASQMAAALLDTMSVELENGGVIFRANGSKVKFPGFMKVYVEGTDDQTDEQDRLLPDLQEGETVFSKDIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTIDTIQKRNYVVLENKRFVPTELGEIVVELILEFFPEIIDVEFTAKMEKNLDEIEEGKVQWVKVVDEFYREFEKRLQIAEKEMKEVEIKDEPAGVDCEVCGSPMVYKMGRFGKFVACSNFPECRNTKPIVKEIGVKCPKCHEGNIVERSSKKKRIFYGCDRFPQCDFVSWDKPLARRCPKCEGVLVEKKLKKGVQVQCTSCDYEEEPQS
(1346) DNA topoisomerase 1 [Paenibacillus sp. JDR-2]
1
MADSLVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQTGVEVENGFQPKYITIRGKGSVLKELKDASKKVKHVFLAADPDREGEAIAWHLAHYLELDETDTCRVVFNEITKQAVKDAFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVCVKLIIDRENEIDAFIPEEYWSITAKLTQQGVPFEAKYHSIKGEKRELHNEEEMQAILAALSGNQFKVAEVKEKERLRNPAPPFITSSLQQEAARKLGFRASKTMSVAQQLYEGVELGKEGTVGLITYMRTDSTRISPVAQEEAKEYIEGKYGPSFYPEQPRVYTKKNSNAQDAHEAIRPTSTLRDPESMKPFLSRDQFRLYKLVWERFVSSQMASAVLDTMTVDLASGDVTFRASGSKIKFAGFMKVYVEGNDDGTEEEHKFLPPFAIGDVVTSDSIEPKQHFTQPPPRYSEARLVKTLEELGIGRPSTYAPTLETIQKRGYVAIEEKKFIPTELGDLVNQLMEEFFPEILDSEFTAKMETDLDHVEDGMEDWVRVLSQFYESFEKRLEVAEEEMKEVEIQDEVSDEICEKCGRHMVYKMGRFGKFLACSGFPDCRNTKPIVKDIGVTCPKCGEGKIIERRSKKGRIFYGCDTYPACDYVSWDKPTNKPCPNCDSMLVEKRNRSGAKLQCPNCDYSEEISEDEQEQA
(1353) DNA topoisomerase 1 [Capnocytophaga ochracea DSM 7271]
1
MAKNVVIVESPAKAKTIEKFLGKDYKVVSSYGHIVDLPSNELGVDIQHGFKPNYLISNDKKNLVKELKALTSKAEVVWLASDEDREGEAIAFHLSETLKLKKENTKRIVFNSITKSAIENAIKNPRGIDYNLVNAQQARRVLDRLVGYELSPVLWKKIKSGLSAGRVQSVAVRLIVEREREIQDFKTQSSYRITAEFITSEGKVVKASLPKNFNTQAEAENFLQQNIGAHFKVQSLETKPAKKMPAPPFTTSTLQQEAARKLHFSVSKTMTVAQRLYESGFITYMRTDSVNLSQEALNTAKNAIVQLFGAQYSQVRKFATKSKGAQEAHEAIRPTDMSRSSIAAEPDQNKLYELIWKRTLASQMADAQIERTTVKIEADKHKEHFVASGEMVQFDGFLKVYLESTDDEEEEQEGMLPNLKKGEALTHRYITATERFTRPLPRYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVERSTLEGEVRPYQQLTLTGNSIKTQTLSERVGADKGKLVPTDIGSVVNDFLVSHFDTIMDYNFTAKVENSFDEIAEGTENWTKMLTQFYNHFHSVVENVEKHTGRETGERVLGTDPKSGRPLSVRLGRYGAMAQIGNPDDAEKPIYASLLAGMSIETITFEEALKLFELPRQLGIVDGKNVEVNVGRFGPYVRYGDAFISLDKGEDVFSITLERAKQLIGEKKKADAPIATYQGVEVTKGVGRFGPFIKWNNTYINVTKKYNFDHLSQQDVEELIEDKLKKESEKVVKEWDEGAIRIEKARWGRFTLLKGKTKVELPKDTDIATLTKEQALTLLTEKEPKAKKAPSKKK
(1356) DNA topoisomerase 1 [Wolbachia endosymbiont of Drosophila melanogaster]
1
MALLIVESPAKAKTIGKYLSKEFKVAASFGHVRDLPAKNGSVDPDNDFTIKYETIEKAEKYIKELVKAASKTSDIYLATDPDREGEAMAWHVIETLKEKKAISNENNIYRVVFNEITKRAVQEAIKNPREINMDLVRAQQARRALDYLVGFSLSPLLWTKLSGSKSAGRVQSVALKIICEREDEISKFITQEYWSIKAEMQNSKDEAFFAMLSHYDNKKLEKFDIKNEEEAKNLVREIESRQYAVSTVERKQVKRNPLPPFITSSLQQDAVNKLYFNVKSVMRIAQNLYEGIDIGGETVGLITYMRTDGFHIADEAINSIRGSIKSLYGDKYLPQSPRKYVKKVKNAQEAHEAIRPTDINRTPGSIKDYLTPEQFKLYDLIWKRTIASQMESAILDQVVVEISSTDQKVILRASGSSIFFDGFYRVYQDNIEAENEGLLPAMKEGEACKLISVEPKQHFTQPPPRYSEASIVKKMEEIGIGRPSTYATIISVLQDREYVSLDSKRFIPSSRGKIVTIFLETFFQRCVEYDFTAQMEEKLDLISNGHADWKKELGHFWVPFFGHVNSVKQMTHDEVFSGIHDLVIDWFCSEEGRKEVNTKCPACLGGILKLNFGKAGVFLGCSNYPECNHTKEITGSNDNSEYPKSLGIDDITNQEVMIKKGPFGLYLEFNNELKKKKTVSIPKDINVNEIDLSTATQLLSLPKVIGEHPETGKEVKIGLGRFGYYIFYDGRYFSLKKSSKEVLNTELSEAVQIIANSPRKELKSLGVNEKGKEVFICNGRYGFYIKCGKTNVALGKSADIESIDLEKALELIKGKK
(1357) DNA topoisomerase 1 [Rhizobium etli CFN 42]
1
MNVVVVESPAKAKTINKYLGSGYKVLASFGHVRDLPAKDGSVLPDQDFEMLWEVDGASAKRMKDIAEAVKSSDGLFLATDPDREGEAISWHVLDMLNKKRVLNGKSVKRVVFNAITKKAVLDAMADPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFISEEYWNISALLKTPRGDEFEARLVSAHGKRLPPRAIGNGEDAGRLKALLEGASYIVDTVEAKPIKRNPGPPFTTSTLQQAASSNLGFSASRTMQIAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIDAARRAILDQFGERYLPEKARFYSTKAKNAQEAHEAIRPTDFNRSPDRVRKFLDADQIRLYELIWKRGIASQMASAEIERTTAEITAENKGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDEDGRLPEINARETLAKQKINSTQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLATLRDRDYVTIDKRKLIPQAKGRLVTAFLESFFTKYVEYDFTADLEEKLDRISAGELNWKQVLRDFWKDFFAQIEDTKELRVTNVLDSLNEALAPLVFPKREDGGDPRICQVCGTGNLSLKLGRYGAFVGCSNYPECNYTRQLSSENGGEAEGVALNEPKSLGTDPTTGEELTLRSGRFGPYIQRGDGKEAKRASLPKGWKPEDIDYEKAMALISLPRDIGRHPETGKMISSGIGRYGPFLLHDGSYANLETVEDVFSVGLNRAVTLIAEKASKAPGRGARGTPAALKTLGDHPDGGAITVRDGKYGPYVNWGKVNATLPKGKDPQAITIEEALALITEKAGKAPAGKTARGKAKPKAAAAEAKTTKTAAKPKAAKAKAPAKLKKS
(1364) DNA topoisomerase 1 [Bacillus cellulosilyticus DSM 2522]
1
MSDYLVIVESPAKAKTIGKYLGKKYAVKASMGHVIDLPKSQMGVDVEEGFTPKYITIRGKGPILKDLKAAAKKAKRVYLAADPDREGEAIAWHLAHSLNIDEKSECRVVFNEITKQAIKDSFKRPRTINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIDREKEINAFEPEEYWSIDAKFEKDGEAFEAKFISKDGEKLSLKSENDVKEVLKALSGESFQIEKVKKRERKRNPVVPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDIGKLGTVGLITYMRTDSTRLSETAKAEAKTYIESHYGKEYVNQQEAKTKQKSNSQDAHEAIRPTSVDLDPKSVKSYLSRDQLRLYKLIWERMVASQMAPAILDTMSVDLVNNGVAFRATGSKLKFAGFMKVYIEGNDDGKKEEDRLLPEMSEGEQAKAEAIDPNQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQRRGYVALEDKRFIPTELGEIVLELIEEFFPEILNVTFTAKMENDLDSIEDGEEEWVKVIDEFYSDFERRLKTAEEEMKEVEIKDEPAGEDCEKCGHEMVYKMGRFGKFMACSNFPDCRNTKAIVKDIGVKCPECKEGNVVERKSKKRRIFYGCDRYPECEFISWDKPIARKCPKCEHMLVEKKTKKGIHVQCSKCDYREDQN
(1366) DNA topoisomerase 1 [Oligotropha carboxidovorans OM4]
1
MNLVIVESPAKAKTINKYLGSSYEVLASYGHVRDLPAKNGSVDPDANFQMIWETDPKAASRLNDIAKALKGADKLILATDPDREGEAISWHVLEVMKQKRALKDQKVERVVFNAITKQSVTEAMNNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREIEIEKFVAREYWSLVATLATPRNDTFEARLVGADGKKIQRLDIGTGAEAEDFKKALETAAFTVSLVEAKPARRNPQAPFTTSTLQQEASRKLGFAPSHTMRIAQRLYEGIDIGGETTGLITYMRTDGVSIAPEAIPALRKVIAEEYGSNYVPSAPRQYTSKAKNAQEAHEAIRPTDVSRRPAKLKARLDNDQYRLYELIWMRAIASQMESAELERTTVDITAKAGARTLELRASGQVVKFDGFLAVYQEGRDDDPEDEESRRLPAMSEGEALKRESLAVTQHFTEPPPRYSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLSAEDKGRVVVAFLQKFFARYVEFDFTADLEEQLDKISNNEVAWKNVLSDFWRDFIGAVDEIKDVKVSEVLDVLDAMLGEHIYEPRADGGDPRQCPSCGTGRLNLKAGKFGAFVGCSNYPECRYTRPLAASSGTSDRVLGKDPKTNLDVAVKAGRFGPYIQLGEPNDYAEGEKPKRAGIPKNMSPADVELDLAIKLLSLPRDVGPHPEDGEIITAGIGRFGPFVRHGKTYASLEAGDDVYTIGLNRAVTLIAEKIAKGPSRRFGADPGKEVGDYPARGGKIMLKKGRYGAYVTIDGINATIPDDKEPDQITLEEAIALIEARAAKGGKAKRAPKKAAAKKAAPKKKATAKKKADSEPESGAKPAKKAATRTAPKARTSTAKPAAKTAAKAKPTAKKSAGKARG
(1368) DNA topoisomerase 1 [Bradyrhizobium diazoefficiens USDA 110]
1
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDANFKMIWEVDPKAAGRLNDIAKSLKNADRLILATDPDREGEAISWHVLEVLKEKRALKDQKIERVVFNAITKQAVTDAMKHPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVAREYWSLVATLLTPRGDAFEARLVGADGKKIQRLDIGTGAEAENFKKALEAAAYAVTAVDAKPARRNPQAPFTTSTLQQEASRKYGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDPSAITQARKVIGEDYGNAYVPEAPRQYQAKAKNAQEAHEAIRPTDMSRRPDSMSRKLDSDQARLYELIWKRTIASQMEAAELERTTVDITAKAGGRTLELRATGQVVKFDGFLALYQEGRDDEEDEDSRRLPAMSAGDGLKRQSLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLHGEDKGRVVVAFLESFFSRYVEYDFTANLEEQLDRISNNEISWQQVLKDFWNGFIGAVDEIKDLRVAQVLDVLDDMLGQHIYPPRADGGDIRQCPSCGNGRLNLKAGKFGAFVGCSNYPECRYTRQLAADSEATADRSLGQDPDTGRDVWVKAGRFGPYIQLGEQKDYEEGEKPKRAGIPKGTSPGDVELELALKLLSLPREIGKHPETGQPITAGLGRFGPFVKHEKTYASLEAGDEVFDIGLNRAVTLIAEKVAKGPSRRFGADPGKAIGDHPTLGTVTVKSGRYGAICHRRRRQRDDPGRVRKGHRHAAAGDRTD
(1371) DNA topoisomerase 1 [Coxiella burnetii RSA 493]
1
MVKSLVVVESPAKAKTIEKYLGKDFKVMASYGHVRDLIPKEGAVDPEDHFKMHYQAIERNIRHMDAIAKALKPCHNLYLATDPDREGEAIAWHVKQMLESRNGLKDKKFSRVVFHQITKKAVQHAIENPRDISMDLVNAQQARRALDYLVGFNLSPLLWKKIRPGLSAGRVQSPALRLIVEREIEIENFESQEYWTIHADCHAQQQPFDARLIEFQGEKLEQFSIVNEKQAHETRDAITQAANGKLTVAKVVKRERKRNPAPPFITSTMQQEAARKLGFSASKTMQIAQQLYEGVNLGEEGAMGLITYMRTDSVTLASEALQEIRQLIEEKYGQENVPEQTRIYKTKSKNAQEAHEAIRPTSAFRTPENLKKYLNSDQLKLYTLIWKRTIACQMIEATLHTVAVDLKAPNAIFRANGSTIVKPGFISVYQETFDDKKKEEESDSKMLPPLEEGQTVDVNEIKSEQHFTEPPPRYTEASLVKALEEYDIGRPSTYASIIATLKNRKYVDVDNKRFIATDVGRIVNRFLTHYFTKYVDYGFTAKLEDELDDIARGEKTWIPVLETFWSPFKNLVDVTEKTVKRSDVTQEKIDEKCPKCSAQLSIRLGRRGRFIGCTAYPDCDYTRNLTEIAAEAQAVLEGRQCPECQSNLIIKMGRYGKFIGCSGYPNCKYMEPLEKPKDTNVTCPKCKKGTILQRKSRRGKIFYSCARYPDCDYALWNEPVAEACPKCGWPILSIKTTKSRGTEKVCPQKSCNFIEAYDGDKPSLD
(1372) DNA topoisomerase 1 [Natranaerobius thermophilus JW/NM-WN-LF]
1
MASNLVIVESPAKAQTIKRYLGKQYKVKASMGHLIDLPKSQMGIEINEVFKPKYITIRGKGKILSELKKEAKKADRVYLAGDPDREGEAICWHLGRALGIDEDEHCRVEFNEITKDAIKAAFKEPRKIAYNLVNAQQARRVLDRLVGYNISPILWKKVRKGLSAGRVQSVAVRLICDREQEIKEFVPEEYWTLIAQFSKDGEKFEGKLQEVDGKKAEIPNEERMNEILSKLENATYKVHKVEKKERKRNPNPPFITSTLQQDAYRRLGFSARRTMRTAQQLYEGIKVSGEGHVGLITYLRTDSTRISQSALTAAKEYILEEYGEDYYPGKPRTFKGGKGSQDAHECIRPTRTDLSPEKIKSALSNDQFKLYKLIWNRFIASQMAPAKYDTVAADIYAAGTMKFRARGSQLKFPGFLALGHEDQDKDEILPELKQDDLLDLEELQPNQHFTQPPPRYSEASLVKTLEKEGIGRPSTYAPIIETIQTKGYVIQEEKRLYPTQLGEIVVEQLKEFFPDVLDVDFTAEVEQGLDKIEDGEKDWQEFLYEFYEPFEKQVKTAEEEMKKIELEEEQTDVECEKCGSYMVVKHGRYGKFLACPNFPDCKNTKSFVKELNVECPKCQGTIVERKSKKGRKFLGCNNYPDCDFITWYKPVEGKKCPKCESFLVQRGKKNKYYQCSHPDCDYSADAVEEQEEKQS
(1373) DNA topoisomerase 1 [Syntrophus aciditrophicus SB]
1
MPDSLIIVESPTKVKTLKKYLGADYEVLASKGHIKDLPKKTLGIDPQNEFQPTYSVIDDKKKVIADLKKAAKNVSRIFLAPDPDREGEAIAWHIAEEIKAKNKEIYRVLFNDLTKNTILDAINHPGKLDFNKYEAQQTRRILDRLVGYQISPILWEKVKRGLSAGRVQSVAVRMICDREEEIKRFIPEEYWNISVQLKGVTPPPFEARLIKITGKKAKVKNEAQANEIVSRLSGGVKSGSKPTINLSEDRDLQPQFVVSKLEKKEVKKESLPPFTTSKLQQEASRLLRFSAKKTMATAQKLYEGIELGEEGPVGLITYMRTDSVRIAEDALKEVRSYIRENYDPPFLPAKARFFKSKGKTQDAHEAIRPSSMNYNPQKIKHFLSADQFRLYQLIWNRFVASQMNPALYDQTTVEVSADFYTFRAQGAILKFPGYTIVYTEGKEDKEQNEEMESGKILPDLNEGERLTLLKITPEQKFTQPPPRFSEASLVRELEEQGIGRPSTYAAILSTIQDRNYARLEQGKFHPTELGTIVTELLVKNFPKVMDVSFTASLENQLDLIEEGKQKRIETLQEFYAPFEEDLSKARLEMKNIKREETPTDLICEKCQSPMVIKWGKNGKFIACSNYPACKNTRNIEQGEGVERSAKGGEMTDTVCPKCGKNMLIKHGRFGRFLGCSGYPDCKHTMPISLGVKCPQEGCDGEIIEKRTKKGRSFFGCSNYPNCTFAVWDKPIPEPCPQCNSPFLVEKYSRTEGSYKACPNKDCGYRDDQS
(1379) DNA topoisomerase 1 [Lactobacillus amylovorus GRL 1112]
1
MPTKAKSKPKTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFDDNYKPKYISIRGKGDTIKELKSEAKKAKEVYLASDPDREGEAIAWHVAHALNLDENAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKEFKPKEYWSIDADFKKGKDSFKSAFYGVDSKKKELPNIDAVKEVLAKIDKKKDFEVAKVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRISPVAQQEASKFLHEKYGAEYAAKSQRHFKNQEDAQDAHEAIRPTSVYRTPESLKSVLTTEQYRLYKLIWSRFVASEMKPAVYDTVRADIVQNGVMFRTTGSKMKFAGFTQVYDNQQEKNVDLPDLEEGDKVQMTKSDNKQHFTQPPARYTEASLVHALEENGVGRPSTYAPTIDTIQRRYYVKLEGRSIVPTELGEIVDTLIEQFFPDIANVDYTAHLEDELDEVEDGKKQWVNVVDEYYQPFKKELDKADSEIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKEIGVVCPKCGKGQVVEKKSRRNRKFYGCSRYPDCDFVSWDKPIGRNCPNDGHFLVEKRSKKGPVILCPNGDYREDPQEDEIDK
(1381) DNA topoisomerase 1 [Roseobacter litoralis Och 149]
1
MPVVVVESPAKAKTINSYLGDNYTVLASYGHVRDLPPKDGSVDPDAGFEMLWEVGYDSRKHVKAIADALKEDNALILATDPDREGEAISWHLQEALTKRKSIKKDTPVSRVVFNAITKAAVTEAMQNPRQVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVTLRLIVEREMEIEAFRAREYWSVKALLATPRSQEFEARLTVLAGKKLDRFDIENQTQAELAVQAITSRDLSVKSVEAKPANRNPSAPFMTSTLQQEASRKFGMGARQTMSTAQRLYEAGYITYMRTDGIDMAPEAVSAARDAIKTLYGADYVPKSPRIYKNKAKNAQEAHECVRPTDMMTKAEDLKTSDADQRKLYDLIWKRTLACQMEAARLERTTAEIASEDGQIGLRATGQVMLFDGFLRVYEEGRDDVAVVDDDDKRLPQIGQGDRLDKRTVTPEQHFTQPPPRYTEATLVKRMEELGIGRPSTYASVVTTIQDREYVRKDKNRLIPEDKGRLVTAFLSNYFRKYVGYDFTADLEDQLDTVSAGNADYKEVLGRFWRDFSAAIAETADLRITEVLEKINEVLEPHLFPANEDGTDPRLCPNCGAGRLSMRTARSGGAFIGCSNYPECRYTRAFGPPGEEDDSGIPPEGKLLGEDGEDKIYAFKGRFGPYVQRGEVTEDNKKPPRQSIPKDWPPEDVDLPQALKLLSLPREIGPHPEDGITVWANIGRYGPYIKHAPSTSDRGGTNANLEGIDEVFTVGMNRAVQLLAEKLASRGQRGGAAKTLRDLGEHPEEGGPIAIMEGKYGPYVKWEKVNATLPKDSDPAGLTMEAAVALIDEKAASKGKKRRKAAPKKTAAKKTATKKAAPKKTAPKKKAQAKKAEE
(1384) DNA topoisomerase 1 [Desulfovibrio salexigens DSM 2638]
1
MSKDLIVVESPAKVKTISKFLGRNYQVAASVGHVRDLPKNKLGVEENGDFTPQYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIGWHVAAIIKEVNENVSRIQFNEITARAVKEALEHPQPLNEQLFDSQQARRILDRLVGYKISPILWKKVKRGISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWKVDGKKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDANRRLGYSAKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVILDKYGDEFYPAKPQVYKSKGGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNRFIASQMAPARFWDTVVTIQAKNTIWRSKGERLLFPGFMRVTGKTGDEKLIELPKLEKGEVLKVDKIESEQKFTQPPARYSEASLVRELEEKGIGRPSTYASIISTIQDRGYVNLEEKKFIPTELGFVVSDQLSEHFKELMDVGFTAAMEKQLDDVADGKIEWTSLMKDFVDGFYPTLETAAKEMKRGGEDTGITCDKCESPMVIKFGRTGEFLGCSNYPECKNIVNFTRDEKGKIVVLEEEPPEETGVTCEKCGSAMAIKRSNRGEFLGCTGYPDCRNIKNFERDDEGKIKVVETPTAQIVGKCPDCDDGDLIIKHARTGSRFIACSNYPDCKHAKPFSTGVKCPREGCKGELVEKSSRRGKLFYSCDQYPDCDYAVWYPPIDGPCPKCGHPVLVKKTTRAKGEHIACPEKGCGYVQGEEES
(1388) DNA topoisomerase 1 [Brachyspira intermedia PWS/A]
1
MESPAKAKTINRYLGSDYLVMSSMGHLIDLPRSRLAIDVDHGFEPEYITIRGRAKILNDLKKEAKKAEEVLLAADDDREGESIAWHIGNKIRGVNSAVPIKRIVFHEITKDALKEAIDQPRDIDISKVNAQKARRVLDRLIGYNLSPLLWDKIKRGLSAGRVQNVALLIICNREDEIETFVPVEYWTFGVFLKHKNKEFLAELQKYKGEKPDLKTRQDVEDIMEHLKDKTYTVASIEVKDRLRNPTAPYTTSKLQQAASSALGYSASKTMQVAQSLYEGVDIAGEATGLITYMRTDSVRISPVAQEQAKEFIEKEYGSNYLPPEPPTYSVKKNAQDAHEAIRPTNVFLTPDSIKEYLKTDQYKLYKLIWERFVSSQMLPAKMKNTRAIIVAGDCEFSLSSSKIEFDGFMKVLTIDKEDKEKASKMPNLSKDDVCEFVENNPQQHFTTPPPRYTDASLVKILEESGIGRPSTYAPTIKTIISRHYVQRKGKQLVPTELGKLVNELISENFPELVNINFTADMESKLDKIEDDNIEWNNILKEFYPHFLDTLKTATENINNMKDFFNEETDFVCEKCGKKMIKRLGRYGYFIACSGFPECKNTKGISFGVCPKCGGDITLKRSKRGREFYGCSNYPKCDFVSWDKPLQEPCPKCGGLMVEKNIKNKGLFKVCIKEDCGYSEEIKEDEE
(1390) DNA topoisomerase 1 [Ethanoligenens harbinense YUAN-3]
1
MSNLVIVESPAKAHTIKKYLGRGYTVVASMGHVRDLPKSRMGVDIENSFTPKYIPIRGKAPLIKSLKKEARNSTKIFLATDPDREGEAISWHLANLLGLDEKTALRVTFNEITKTAVKDGIKNPRSIDLDLVNAYQARRILDRIVGYQLSPFLWKKIRPGLSAGRVQSVAVRLIVDREDEIRAFVPEEYWTIDASELLAPGSKKPFPAHFHGGLDGKKVEIKSKEEADAILRALGATETPEGIQVSGEVPFVVRTVKKSERKKSPAPPFTTSTLQQEASRRLGFQARRTMRAAQELYEGVDVKGYGAIGLITYMRTDSLRIAAEAQQAALAYVGETFGREYLPEKPRFYKSRANAQDAHEAIRPTMPELSPDQVKESLTADQYKLYKLIWERFIASQMANKVLDTVGVDITAGDCLFKASGNTVKFKGFSIVYEMTTDENKESGKPLPVLNEGDELQVQKLDGNQHFTQPPPRYTEASLIKTLEENGIGRPSTYATTITTILARLYVERDGKQLVPTPLGEVTTKLMREHFADIVDVEFTAKMENDLDKVETGEENWVQMLTDFYGGFDHTLKKAEEELGDVHMKVPDEETDIVCELCGRKMVIKNGRYGKFLACPGYPECKNTKPIVQETGAFCPLCGGRVLAKKSKSGKKYFGCEHNPTCGFMTWDTPLEEKCPQCGGSLFKKRGGQVYCAKEGCGYTREEKK
(1393) DNA topoisomerase 1 [Spirochaeta thermophila DSM 6578]
1
MKKKRDTNTNPYTLLVVESPAKAKTIEKYLGKGYKVEASKGHLIDLPKSRLAVDIEGSFEPDYIVVRGKAPILKALQEKANASSKVLLASDNDREGEAIAYHIRDALLKKNPDLEIGRIVFNEITPQAIREAVEHPRSIDIHKVEAQKARRVLDRLVGYHLSPLLWKKVKNGLSAGRVQSVALRLICEREREVESFVPEEYWTIAARAVVGRSSLDLELVSYKGEKPQIKTEEEAGKIIALLREHPCRVKSLKETSRQVRPKPPFTTSQLQQVAANRLGFSSQKTMQIAQRLYEGVDLGGTRIGLITYMRTDSTRVAESALSMVRNYIQTHHPEALPDAPVRYARGKGAQDAHEAIRPTVVDYTPDHVKQHLSRDEWRLYSIIWERFVASQMKPMVTKTVTVECEVGEGVLRASATQVVEPGFLSVLSVLKPKDTSKKLPPLEEGQELTIEEWIPSQHFTTGPSRYTDATIVKALEELGIGRPSTYAPTIQVLFNRYYVVRKERQIVPTELGKVVNDILVQSFPDILDVDFTARMEAQLDEIEEGKVEWVSMIREFFGPFREKVDHVMEHLESIKGTLEEETGETCEKCGRPMVKKLGRFGYFLACSGFPECRNARPLPLADCPMPGCDGKIVERRGRRGRRRVFYGCTRYPECSFTSPYPPSGTSCPMCGWPLMEKTSKEGSVKLCVNPSCSYLHEREGEVPVVIDGSDTSELEISTVGSEE
(1396) DNA topoisomerase 1 [Erysipelothrix rhusiopathiae str. Fujisawa]
1
MKNLVIVESPSKSKTIEKYLGEDFEVVSSKGHIRDLATTGKGGLGVDFDNDFEATYKISKDKKDVVKELKAKAKKADAVYLATDPDREGEAISWHLANELGVDLDQDNRVVFNEITKDAVLSAFESPRHIDMNLVKSQETRRILDRIIGFKLSKLLQAKIKSKSAGRVQSVALKLIVDREKEIDAFTPEEYWSVLAFFENEGNIIETSAERFKGKKLKLTNEAEAQAVLDAAQGSFNITKLEKKKRKKESKLPFITSTLQQEASTRLGFPAKKTMRVAQKLYEGIQMGADTEGLITYMRTDSTRLSNVFVEDAKAFIVEEYGKEYLGKYRQGKKTENTQDAHEAIRPTSISRRPEEVKSYLTPDEYKLYRFIYYRTLASLMAPSISDSVSVVFSQNDYDFNGSGSIMTFDGYLKVYEYEKTTDKVMGELDETKAYNAQKIEKNQHFTQPPARYTEARLIKELEELGIGRPSTYSMILETIVYRAYATFGAVSETSKTKVFKPTDQGILTNEKLQEHFSDIINVHYTANMEDELDRIAEGEENNVEALQRFVDKFYPLLEEADEKMEKIEVEKVGEVCPDCGGELVYRFGRYGKFIACGNFPECRYNRALDQDKRPEPEKTGEVCPDCGEPLVKRKSRYGTFFVGCSGFPKCRYIQPNENAKKPKTKKPEEVSAEHEPLGEEIKD
(1399) DNA topoisomerase 1 [Desulfotomaculum acetoxidans DSM 771]
1
MSTTLVIVESPAKAKSIGKFLGKKYTVKASMGHVRDLPKSQFGVDVEAGFMPKYITIRGKGDTIKELRSAVKKADTVLLASDPDREGEAIAWHLQKLLKIEDNQPCRIEFNEITKQAIQNAVTHPRKIDYNRVNAQQARRILDRLVGYNLSPLLWRKVRKGLSAGRVQSVAVRLICEREEEIDSFEQVEYWTLTGKFLKAKAGFEGKLLKYRGEKLEVSDEESMQKILQALEGSSYVIEKVSRRERSRRPAAPFTTSSMQQEAYRKLNFTARKTMVVAQQLYEGLDLGKEGSTGLVTYIRTDSTRVSGTAKEEAKEYIDKQFGQAYTGEQDGEIKGQKERKIQDAHEAIRPTSVFREPDQVKKFLTPEQYKLYRLIWSRFVASQMSPAIIDTTSVDIAAGEYTFRSAGSIVKFSGFMKVYTEGNDDGQKEEIKTLPELAEGEKLELTELLPKQHFTQPPPRYTDASLIKLLEENGIGRPSTYAPIVETIQKRGYVSRENKQFFPTELGFVVVEMLKEHFPEIIDVEFTADMEKKLDHIEEGDTDWIKILEEFYGPFHETMEKAEEAIGKIELQDEVTEEICELCGRNMVIKFGRFGKFLACPGFPDCRNTKPLLEPTGVTCPLCSGEVVLRRTKKGRKFYGCSRYPECDFVTWDLPTNEKCPSCNSMMVKKSSKNKQMLSCVNQECKLKIEMSEDKK
(1400) DNA topoisomerase 1 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305]
1
MAENLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDAENDYEPKYITIRGKGPVVKELKKHAKKAKKVFLASDPDREGEAIAWHLANILNLEDSTENRVVFNEITKDAVKDSFKHPRGIEMELVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWKIEGEFRYKKTKFTAKFLHFKNKPFKLTEKADVEKITTQLDGDQFEVTKVTKKEKTRYPANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKKQGTVGLITYMRTDSTRISDQAQSEAKNYIQETYGNDYTSNRKSKGQGDQDAHEAIRPSSTLRTPNEMKNFLTRDQHRLYKLIWERFVASQMAPAILDTVAMDLTQNDIKFRANGQTIKFKGFMTLYVETKDDSEDGKDNKLPNIGEGEMVTATNIEPSQHFTQPPPRYTEARLVKTMEELKIGRPSTYAPTIDTIQKRNYVKNESKRFVPTELGEIVHEQVKDYFPEIIDVDFTVNMETLLDKVADGEIGWKKVISDFYSSFKQDVERAEEEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPKCKEGDVVERKSKKNRIFYGCSKYPECDFVTWDKPIGRDCPKCEHYLVEKKQGRKSQVVCSNCDYKEEEQK
(1403) DNA topoisomerase 1 [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
1
MLKLPKKSEKNKLVIVESPAKAKTIEKILGSSYKVISSYGHIIDLPKTKIGVDVNNDFKPSYNTIKGKGEVIKQLKEASKKADKIYLASDPDREGESIAWHIANTLKLDHNEKNRIEFHEITEKAIKDAVKNPRKINIARVNSQQARRILDRLVGYEISPFLWKLISPNTSAGRVQSVALKIICELEDKIKAFVPEKYWDVKGIFDTKYSLNLYKIDNKKIDKLKDEKLLDRVKKDLKKKYEVISSKVSKKTKNPPLPLKTSTLQQLASSYLGFSASKTMMVAQKLYEGISIKGEHKGLITYMRTDSTRISEEAKEMARNYITKNFGKEYLGSATPKAKKESKNVQDAHEGIRPTDINYTPENIMEFLDKDQFKLYNLIWQRFLISQLAAMKYEQFEYILEKDKIEYRGTINKIIFDGYYKVFKEDEDLPIGDFPEIKEGDKFTLDKLDIKEDYTKPPARLTESSLVKTLEAEGIGRPSTYASIIDTLKKREYVELQNKSFVPTEIGYEVKTQLDKFFPNIMNIKFTAKLEDELDEVDSGDKNWIDLLKVFYTELQKYEEKCKVVVEEELEKLVESDVIAKNGKPMIMKIGRFGRYLASQDTESKENISLKGIDISLEDIKKGKIFVKKQIEELGKKKEGQKTDIILDNGSRLLLKYGRFGAYLESENYKEDNIRKTIPKEIKTKIEKNTIKKENDILYLKDIFDKIEKEEAEILKKAGKCEKCGRPFKISNGRWGKFLACTGYPECKNIKKIEKK
(1404) DNA topoisomerase 1 [Xanthomonas axonopodis pv. citri str. 306]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNGFAMRYDLIEKNEKHVEAIARAAKGADDIFLATDPDREGEAISWHIAEILKERGLLKDKPMQRVVFTEITPRAIKEAMAKPRMIAGDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIPREYWSIDAHCRHPSQAFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALAEIRDVIARDFGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSEDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVPGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNVPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTANLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGTDPVSGKEVSARIGRFGPMVQIGTVEDEDKPTFASLRPGQSIYSISLEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSTYASLKKEDDPYTIDLARAIFLIEEKEEIARNRVIKEFDGSDIQVLNGRFGPYISDGKLNGKIPKDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNTVKDSAPKKPAVKKTATKTAASKTAVKKAPAKKTATKKAAKRVVKKTVSKAAG
(1405) DNA topoisomerase 1 [Pseudoxanthomonas spadix BD-a59]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNNFAMRYDLIEKNQKHVEAIAKAAKGADDIYLATDPDREGEAISWHIAEILKERNLIGNKPMHRVVFTEITPRAIKEAMARPRAIAGDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIAAACAHPSQPFTAKLVKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVTSKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGAVGLISYMRTDSVNLSQDALNEIRDVIARDYGTASLPDQPNIYLTKSKNAQEAHEAVRPTSALRTPSQVARFLSDDERRLYELIWKRAVACQMIPATLNTVSVELAAGSAHSFRASGTTVVVPGFLAVYEEGKDTRSAEDEDEGRKLPAMKPGDSVPLDRIVAEQHFTQPPPRFTEAALVKTLEEYGIGRPSTYASIIQTLLFRKYVEMEGRSFRPSDVGRAVSKFLSGHFTRYVDYDFTAKLEDELDAVSRGEEDWIPLMARFWGPFSQLVEEKKESVDRAEASGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEDKPRFASLRPGQSMHTISLEDALELFLMPRALGQDKGEEVSVGIGRFGPFAKRGSSYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKTFPDSQIQVLNGRFGPYISDGKLNGKIPKDRDPASLTGEEVIRLLEETGKPVRKGFGAKTPQKGAKTTARKVTKKAEPAEKKPTASKAVKKATGKTARNPGKGTGAASKLAAKKTVAKKSVAKKAASQGAAPF
(1409) DNA topoisomerase 1 [Cytophaga hutchinsonii ATCC 33406]
1
MPKNLVIVESPAKAKTIEGYLGKDFTVKSSYGHVRDLQKGDKAIDIANNFTPTYEVSPDKKDVVKELKKLAKEAEMVWLATDDDREGEAISWHLKESLDLDDKKTRRIVFREITKNAILNAVQTPRGIDIDLVNAQQARRILDRLVGFEMSPVLWKKIKAGLSAGRVQSVAVRIVVDREREVDQFNATALFKVTAEFKDGTKTIKAELPNRFETEAEAQAFLDKLVGADFFVRDLEKKPAKKSPSAPFTTSTLQQEASRKLSFSVAQTMTVAQRLYEAGKISYMRTDSVNLSDFAIDAARTTITTNYGGEYAFTRKYKSKSENAQEAHEAIRPTDFNVQQASSDRNEQRLYDLIWKRAIASQMADAKLERTVVTIGNNKGPENFIATGEVITFEGFLKVYLESKDEEDEDEEEIEAKTGGTATLPPLTVNQKLGLNQIVAVERYTRPPSRYTEASLVKKLEEMGIGRPSTYAPTISTIQKRGYVIKEDRDGRERKLKQLTLKDNAVKAAVITENTGQEKSKLFPTDLAMITNDFLVEHFPRVTDFNFTAMVEKEFDDIAEGKIKWQSMLKGFYGDFHEQVLKTENIDRSTVNTSRILGTHPETGEQISTRLGRYGPFVQIGEADEEKGIKPKYASLRKGQLIENITLEEALELFKLPRELGAFEDKPMVVAIGRFGPYIRHNSKFVSIPKIDDPMTISAERGIELILAKRVSDAEKLILEFPESEYVKVLKGRWGPYLAIGKNNFKLPKDKEPASLTYAECLAIAGLDHDPTDVDAGLAKAKKGKAAAKKTTTAKKTAVKKAAVKKPAAKKPAAKKAVAKKAAAKKPAAKKASAKKTTAKK
(1412) DNA topoisomerase 1 [Filifactor alocis ATCC 35896]
1
MAKNLVIVESPAKAKTIEKFLGKKNYTVKASVGHIRDLPKSKLGVDVEQNFEPQYITIRGKGDIVKDLKKEAKKADFVYLATDQDREGEAISWHLAYLLDLDINDNNRITFNEITKDAIKKAIKSPRKIDLDLVDAQQARRIIDRLVGYKISPILWIKVRKGLSAGRVQSVSTRLIVEREEEIRAFTPEEYWTIDATVTGEDKRKAVFKLTEKNNKKIELHSEEETKLVLKDLHKKDMLIDKIDSKEKKRSAPKPFTTSLLQQEAGNKISFSSKRTMSAAQQLYEGVTVKGEGTVGLITYIRTDSQRISEEALASSKKYIEETFGKNYYQKYSSPKKKNSSIQDAHECIRPTSIYRTPESVKDSLTTDQYKLYKLIWERFVAASMSSAIFHTDTVLGSIDDYQFKVSGSTLVFDGFLKVYSYSKAEEQEIPNFVEKQYYKVNKLTDKQHFTQPPARYTEATLIKTLEELGIGRPSTYSPTISTILQREYVKKEKNFLIPTELGEIVTSIMKENFKNIVDVDFTADMEKQLDSVEEGTLPWKSVVEKIYTPLIEDVTVAEENLEKVLLQEKTDEKCPVCNEEMVVKYGRFGKFLACKNYPECTGTKPYLEKIGMPCPDCEDGEVIIRRSKKGRIFYGCSNFPNCSFVSWNRPTGKKCPECQENLVEKVTKKGTQIVCSSKTCSYKEEVKQ
(1413) DNA topoisomerase 1 [Chlorobium phaeovibrioides DSM 265]
1
MAVKTPSLSAKNRTLIVVESPSKAKTINKYLGDGYAVFASVGHIKDLPKKEIGLDFDNHYEPSYEVIAGKDKVVRQLKKLSAEASAVMIATDPDREGEAIAWHIANEIGKTSKPVTRVMFNEITKSAILEAIADPRQIDYKLVRSQQTRQGLDKIVGYRISPFLWNVVMRGLSAGRVQSVALRLICEREMEINRFEIQEYWTIAADFITSEKESFKARLISINGEKPDLKNQASAEAAAALVSKGNYRLKAIAPRTQQRRAPLPFTTSLLQQAASNQLGFGSKKTMRAAQQLYEGIDLGSEGATGLITYMRTDSIRIGDEAKGQARHFIENTFGKEYIGFGGAAAKSSKNAQDAHEAIRPTSVNRRPEDLKPYLSTDQYRLYDLIWKRFVAAMMAPAKIEQTRVDIADPEARISFRANGSRVLFPGFMKVFNDQEELAYEERKSTKDEGEKEQTVRLPKVLRENDPLNLGPIDSRQSFTRPPARFSEATLVKDLDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTVLGMDVSEILVSNFPELFNVDFTAGMENELDKVAVGEDDYESVLDRFYKPLEATLSARKEDPVIPQNRDAAPCEKCGEGRMIVKWTQSGKFLGCSRYPKCRNNIPIATNKEKPKDTGILCPSCNEGHMLLRNGRHGAFLACSSYPKCKGLLNLGKQRQIEPMKLPPVLTDLTCPKCGAPMNLRIGKRGPWLGCSKFPKCRGRMAWNSLEEPVRLHWEEVMAEHIKANPAITITMIDGNPASMTMPIDDIITSAEERGLVRIEAEEQAAEKTPVTE
(1415) DNA topoisomerase 1 [Anaeromyxobacter dehalogenans 2CP-C]
1
MAKEPKTGAVAVKKKKAAAAPKEATAVAEAEAPKTPRRAARKTSTGTSLVVVESPAKAKTIKKYLGRAYDVKASVGHVKDLPKSKIGVDVEKGFLPEYDVIKGKAKVLSEIKRAARTADHVFLATDPDREGEAIAWHISEELGSEGGDARVRRVLFNEITKTAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFVPVEYWSLDADLAAQVPPDFRAKIFKVDGQKADLKQGEETLALVKELEGARYVVASVDRKERKRNPPPPFTTAKLQQEAANRLGFSPKKTMTLAQRLYEGVELGDEGAIGLITYMRTDSVRLATEAVDAVRAHIQQAYGKDHLPEQANVYKTKAKAAQEAHEAVRPTSLEWTPDRVAPFFDQMGERDMYRLYELIWNRFVACQMVPAVYDQTAADIAAGRAVFRATGSILKFPGYLAVYGAKPPEEEAGAEEEKSNGDAAEPAARAEDRQLPPLEAGMELRLLKLLPEQHFTQPPPRFNESSLVKEMEERGIGRPSTYAAILDTIQEKGYVEKLEKQFKPTHLGVLVTDELVRAFPREMDIAFTASMEEKLDEIEEGSAGWQRVLEEFYVSFKEDLAKADEAMRNVKAQAIETDITCEKCGQHKMVIKWGRNGEFLACPGYPECRNTMNFRREDGNIVPEKEEDVPVEDKCPECGADMVMKRGRFGRFLACTRYPDCKGTKPVSIGVTCPKGCGGYISEKRSRRGKTFYGCSSYPKCDFVAWDRPRNETCPQCGSAYLLDKYSKKTGPFVACPNKECGYRREAEPREGGAAAAQVEPAKA
(1416) DNA topoisomerase 1 [Desulfococcus oleovorans Hxd3]
1
MNKPVIIVESPTKVKTITKYTGNAYSVTATSGHLRDLPPHELGIDIDNGFAPDYVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIAFHVADLLKKKGRRFHRVMFHELTKTGIQKGLTEPTELNRNRYDAQQARRILDRLVGYQISPLLWRKVRNGLSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVKKGTKNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAIRKLGFTAKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPEAAHEALAHIRSVFGNDYAPDRPRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKRFVASQMSEAQIDQKTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDKLPQLDEKEVLKLIELDPKQHFTTPPPRFSEASLVKELEENGIGRPSTYATILSTIRDKGYVDLINKAFRPTELGFIVNDLLVENFPTILDIEFTANMENDLDRIESDQLQAVRLLERFYGPFSQRIEAAKDRMRSVKGVGMDTGLSCPECGKELKIKLGKNGPFLACSGYPDCKFSRNYARTDKGTVEPVEPDLTVAEGKSCEKCGSPMVVKQGRYGDFLACSAYPDCKSTQSLNSGANAAPIGVKCPEPGCNGDIVEKKSKRGKVFYGCSRFPKCTFASWDKPVDMACPDCGAPFVVEKTTKKEGTVLTCASEGCGFRQRT
(1418) DNA topoisomerase 1 [Acetobacter pasteurianus IFO 3283-01]
1
MTDVVVVESPAKAKTINKYLGDGYTVLASFGHVRDLPPKDGSVLPDEDFAMKWQSDERGMKQVAAIAKALKGAHRLYLATDPDREGEAISWHVRAMLEERKALKGVDVQRVTFNEITKSAIRYAMEHPRDLDFPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFKPREYWSVIASLLTPAGAAFTARLTHLNGKKLDQFDLHNAELAEAAKKAVEAENLAVKSIERRKVRRNPQPPFTTSTLQQEASRKLGMSAQTTMRTAQQLYEGMDLGGETVGLITYMRTDGVTMAQEAINAIRQHIGQKIGTEYVPAKPRIYTSKVKNAQEAHEAVRPTDVSRTPESVARFLNNDQRRLYELVWKRAVASQMESASLDQVAVDIAGPSGQTVLRANGSIITFEGFLKLYREGRDDTEKAADDDARMLPSMQEKDPLKREKVDAEQHFTQPPPRYSEASLVKKMEELGIGRPSTYASILTVLQDRSYVRLENRRFIPEARGRLVTAFLVSFFERYVDTGFTASLEELLDDISGGRAQWKQVLAAFWNDFSKAVSGTKELTITDVLNALDKDLGPFFFPERADGSDPRVCPSCGTGRLGLKLGRYGAFIGCSNYPECQYTRRLTSDSAEEGDDAALKDGMRLLGQNPETGEDITVRQGPWGLYVQQGEPNPEDKKAKPKRASLPKNINGESITLDQALGLLSLPRLVGIHPETGEPIQAGLGRFGPFVKMGAVYGSLDKDDDVLTIGLNRAVDALAKKLASIRNLGVHPKDGEPVMVRKGRFGPYVQHGQMVATLPRGTDMDAVTLDEAVALLADKGKPLKAKAGAKKKATTTKTAAKKKTATKSTAKADAEGAEKAAPKKKAPAKKKATTTTRKKKAETE
(1422) DNA topoisomerase 1 [Isosphaera pallida ATCC 43644]
1
MARFSAASPSRRTTRTSQERSPSRDASIALESHDPTDPIPRFDEVSTDASEPASAHNGATSAASPRTTRTKSVTKKPKAGLSSTATKRTSRKATSAKRSTDNGEPVEGTAGVGSRSGKRQALVIVESPKKAIAIGKFLGSGYVVKASKGHVRDLPKNVLGIDVDHEYRPTYEIIPKKEDTISELKRDANRADVVYLATDPDREGEAIAWHLKEALELPDEKVRRVRFHEITEKAVREAFQHAGPIDHHKVDAQQARRLMDRLMGYPLSQLLWKKVARHLNLSAGRVQSVAVRLIVEREKEIRAFVPEEYWEITATLSAQGKTDELDRFTAKLAEWKGSKFKVDHETQARAIRDALTAAEFVVRSVEDVEKKDPPAPPFKTSTLQQQASIRFRFSSDRTMSIAQQLYQGIDLGDGNTVGLITYMRTDSLRVSDEAIKGVREVIASRYGDAYLPVKPNQYEAGKLAQEAHEAIRPTDLSLTPESIQNRLTHDQFKLYQLIYRRFVASQMTPAIFAVTNVTIEAGEGVFKTQGKMLKFDGYRKVLPPAGKQEDALLPPLVPHQILDLHALEPSQHFTQPPPRYNEASLIKALEKENIGRPSTYATIIQKIQERNYVEQKDRRFYATNLGMVVTDLLVEHFPKMLDLKYTSHIEDELDRIMSAEARMVQVLDEFYHPFQDALKVAETRMPKVQIPSDKVCPTCGAPMVEKYNKAGKFLGCSRYPDCTTIMSADGTLKKAAVETEYQCLKCGKPLVMREGKRGEFLSCSGYPECKETYQLDEDGRLIPTREETDYICSKCGKPMLKRQGPRGPFLGCSGYPKCKNTIQLDDQGQPVKTIEIDVKCPKCGGPMAIKQSWRGPFLGCLNYPKCRGTAPIPPELKESHPELFVNTRAEDPIKAALKSLTIDEPCSKCGKPMVARQGKKGFFLGCTGYPKCREVREPDEATLERIQQAVAAAEGLTAGSPAAT
(1424) DNA topoisomerase 1 [Methylotenera mobilis JLW8]
1
MSKLLIVESPSKAKTLKKYLGSDFEVLASYGHVRDLIPKNGAVDTENQFAMKYDIIERNSKHVDAIAKAVKNADSIYLATDPDREGEAISWHIAEILKSKKLLKNKLMKRVVFHEITKGAVEHAIAEPRDISMPMVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLDALKHQHGFKAKLVQLNNQKVEQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTLQQEAVRKLGFTTSRAMRVAQQLYEGVDVGGGTVGLITYMRTDSFSLATEAVMQIRDYVKKNFDTEYLPKSPVMYKTKSKSAQEAHEAIRPTDISRTPTSVRQYLNDEQFKLYEMIWKRALACQMAPAKFDAVSVDLSVGSDANLFRATGQTLVFPGFIAVYMEGSDDEEEEAESKLPNLETGEILTVEKIYGEQHFTEPPPRYSEASLVKVLEEYGIGRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTKYVDYDFTANLENALDSVAEGERDWVPLMDEFWQDFNQQIHNKADVERPGNELIDEACPKCGKPLQKQLSRFGSFIGCTGYNDTPKCDYKRSIDGTANAGTDPVSIGVDAATSKEIYLMNGPYGPYLQVGMAVEGEKKKPKRVSIPKEIALADVNLETANMLLSLPRDLGLHPETNKKIIANIGRFGPYINHDAKFKSIPKNLSVFSIDLDGAVALLAQAHTGPAPLCSLGSHPTEDGQIEVFAGRYGPYVQHGKLRATLPKSIEPESLTMEEALELLSAKAAKDAPAKKAPAKKAAAKKTVAASEDKPAAKKAAPKKATTKKAAPKKATAKKSE
(1426) DNA topoisomerase 1 [Treponema caldaria DSM 7334]
1
MAAGTKKKQDKKKTLVIVESPAKAKTIEKYLGTEYMVKASMGHLIDLPKSRLAIDVDHDFEPEYITVRGRAKLLKELQGDAKKAEMVLLASDNDREGEAIAYHLQNAIQEKAESTPIKRIVFNEITPLAIKEAVNKPADINEALVNAQKARRVLDRLVGYNLSPLLWKKVKNGLSAGRVQSVALRLICDREREVESFIPEEYWTLDADFKKGKSAFTAQLVSWKGEKPVLPNEKAVQELIEQLKQTKAEVVDRKESEKTIRPKPPFTTSKLQQAAANRLGFTSKKTMQIAQQLYEGVNIGSSRVGLITYMRTDSVRISQAALTDVRNWIAEHYPKDLPQEAISYSVEKKAQDAHEAIRPTYVTYTPDAVKEYLTRDQLKLYTIIWERFVSSQMNPARSKTISLDIACGDGIFRISGSKLIEKGFYRVIKVLTSKEEKDTSLPEVSIGEQLEIVKFYPEQHFTQGPSRYTDATIVKTLEEKGIGRPSTYAPIISVLLERYYVSRSNKQLVPTMLGRMISDMLVEYFPNVVDVGFTATMESKLDQVEENKVSWPQMIREFYDPFSKRVQEVQQTLESYKGSLDEKTEFTCELCGKPMVKKLGRFGYFLACSGFPECKNTKSIPLAKCPRPGCTGDIVARKNKGRGKEFYGCTRYPECDFITHYKPLSINCPKCGWFLVEKYDKQNGTHKACINPDCDYLHSAEDEAGSEHDGED
(1427) DNA topoisomerase 1 [Ehrlichia chaffeensis str. Arkansas]
1
MSLIIVESPSKAKTISKYLGSKYKVVASFGHIRDFPAKSGSVDPDKDFAMTYEIISKSEKYVNKLIQVANKETQGIYLATDPDREGEAIAWHIIEVLKENNAIDDNVVINRMVFNEVTKSAILESIKRPRSINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRESDIEKFITQEYWDIEAKCCNTEGKQFSAFLSCYAGKKLEKFDIKNEEDAQKLSEEVRSRSYSVINVEKKHTKRNPYPPFITSSLQQEASTKLGFTAKNTMLIAQKLYEGIDVGGEIVGLITYMRTDGFYIADEALEHIRSIIVSMFGKEYLPESARKYVKKVKNAQEAHEAIRPTNITITPGSLSNYLTPEQLKLYDLIWKRTVASQMNSAVIDQVIVELGSLDKVVTLRATGSSLFFDGFYKVYGHGEDDDSKNNMLPLLQKNDKCPLDEVVPHQHFTNPPARYNEASLVKKMEEIGIGRPSTYASIISVLQDRQYVILNQKRFFPTERGRIVNVFLVNFFSRYVEYDFTADLEEKLDLISNGKINWKEVLHQFWFLFIDNVNSVKKLEFTEVLKVISCEMENYIFSSDKSESSRVCPVCNDGTLELNISKNGIFLGCSKYPECKYTKNVGSGIVDDTDNTQYPKILGIDAATGQEIYLKKGPYGLYLQIGNDKSGKRAAIPKNIDANLLDLQMAEKILSLPISLGTHPDTGQEIKLGLGKFGAYILYGGKYFSVKNEHNFLDISIENAINIIANNSTSGVIKSLGITEDNKEVFLCKGRYGFYLKYDKLNVALKKDTDIEQISLSDAIKLISEKL
(1428) DNA topoisomerase 1 [Rhodobacter sphaeroides 2.4.1]
1
MAVVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPPKDGSVDPEHEFAMTWEVAADSKKHVRAIADALKTDDTLILATDPDREGEAISWHLQEALASSLKKGKTVRRVTFNAITKSAVTEAMKAPREVDTALVEAYLARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVCLRLIVEREMEIEAFRAREFWTVSAVLATPRGQEFEARLTVLGGKKLEKFDLATSEAAELAVQAVTSRPLKVASVEAKPASRNPSAPFMTSTLQQEASRKFGMGAKQCMSAAQRLYEAGHITYMRTDGIDMAPEAVMAARDEIKRRFGANYVPDSPRMYKNKAKNAQEAHECIRPTDMSASPEKLGLTDTDQRKLYELIWKRTLASQMAAARLERTTVEIASPDGQVGLRATGQVVLFDGFLKVYEEGRDDRSDGDEDDEGRLPQIMANEAVEKKSITPEQHHTQPPPRYTEATLVKRMEELGIGRPSTYASIVSTIQDREYVRKDKNRLIPEDKGRLVTAFLANFFRKYVEYDFTADLEGELDDVSAGERNYKEVLARFWRDFSAAVAETADLRIGEVLDKLDEFLAPHLYPPRPDGSDPRICPTCGSGRLHLKTARGGGAFIGCGNYPDCRYTRPISVTGDEENAISPDGKLLGHDEDGAPISLRSGRFGPYVQKGEVTAEVPKPPRASLPKGWAPDTVDLDRALMLLNLPRLVGSHPEDGQPVEAAIGRYGPYVKHGSTYANLPDVEEVFTIGMNRAVEVLAQKAAGRRGASAPAQPIKELGEHPDGGLLAVMPGRYGPYVKWGKVNATIPKGIEPEAITLEEALALVAEKAGKAPKKKAPARKAKAEEGAPKKAAPKKAAAKTTKTAAKKPAAAKSTAKKKAAPDTDAA
(1430) DNA topoisomerase 1 [Alkaliphilus metalliredigens QYMF]
1
MAKSLVIVESPAKAKTIEKFLGKRNYIVKASVGHVIDLPKSKLGVDIDKDYEPQYITIRGKGPVLKEIRTEAKKAKRIYLATDPDREGEAISWHLANALNIDKNEACRIEFNEITKNAIKSAIKTPRKINHDLVDAQQARRVLDRLVGYKISPLLWQKIRRGLSAGRVQSVATKMIKDREVEINAFQPEEYWSLILQVQNMQKEKFEVKFQSDHLGNKDIKSEDEINIIINKIKDKQLMITEVKQGEKKRNPSLPFTTSTLQQEASNKLGYSTKKTMSLAQQLYEGIELGKEGSVGLVTYIRTDSTRISEEASQHVAQYITEKIGEHYLQKSTIVKKGKKSVQDAHEAIRPTDVTRSPDVMKPYLKKDQYKLYKLIWERFVASRMEPALFDTLSITLDVEGVTFKANGSRLRFEGFLKVYSLASRSEDTDLPVLNKDELTSIVEIDPKQHFTQPPPRYTEASLVRAMEEQGIGRPSTYSPTIATILSRGYVEREGRNLLPTELGILVTGILEDFFSQIIDVHFSAELENQLDEIEEGKKGWKSLIEDFYPSFEEMLKVAEEHIEEIHLVEESDEICDQCDAPMVIKHGRYGKFLACSSYPDCTFTKPIVHKIDVKCPKCEDGEIVERKSKKGRLFYGCSGFPSCRFVSWAKPINEKCPQCNEILAHKKTKKSEKITCTNSECKYERLIEDENEK
(1432) DNA topoisomerase 1 [Streptococcus equi subsp. zooepidemicus ATCC 35246]
1
MCQLVTKTATKSKQETKRSATKKKSAAAKKNLVIVESPAKAKTIEKYLGRQYKVVASVGHIRDLKKSSMSIDFDNHYEPQYINIRGKGPLINSLKKEAKNAKKVYLASDPDREGEAISWHLSHILGLDPDDNNRVVFNEITKDAVKEAFEGPRKIDMDLVDSQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDREHEIKAFVPKEYWSIDGLFKKGTKKFQASFYGLNGKKMKLNTNDDVKLVLSQLSSDDFMVSKVEKKERRRHAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGISLGPNGTQGLITYMRTDSTRISPVAQNDAAGFIVERFGSQYSKHGNRVKNATGAQDAHEAIRPSNVNHTPEAIAKFLDKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLEQNGVLFVANGSQMKFDGYMAVYNDSDKSKMLPEMAEGEVVKKVTLTPEQHFTQPPARYSEASLIKTLEENGVGRPSTYAPTLDVIQRRYYVKLAAKRFEPTELGEIVNQLIVEFFPDIVDVKFTADMEDKLDQIEIGKEAWQNVIDQFYKPFVKELTKAETEIEKIQIKDEPAGFDCELCGHPMVVKLGRFGKFYACSNFPECHHTKAITKEIGVSCPACQQGQVIERKTKRNRIFYGCDRYPECDFTSWDLPVGRSCPKSGDYLVEKKIRGGKQVVCSNEACDYKEEIVK
(1433) DNA topoisomerase 1 [Finegoldia magna ATCC 29328]
1
MANKKLVVVESPTKAKTIQKMLGSGYKVVATIGHLRDLPKSKLGIDIENDFEPRYINVRGKANVINALKKDYKNSQKIFLATDPDREGEAISWHLCYLLGINPKEENRVKFQEITKDSVKEAIKKPEAIDLKLVDAQQARRVLDRIVGYSISPLLWKKVKSGLSAGRVQSVALRLICEREKEIREFEPEEYWSIHANLSKDKLDFDSELYYSKSDKSNKINIKNKDEADKILNDLSDKFVVDSIKQQKKARKPYAPFTTSTLQQEAYKKLYFQTSKTMRIAQQLYEGISLGSEGSVGLITYMRTDSTRISQVCVNDCLDIINELYGKQYATRGYDYSKKKKGSQDAHEGIRPSSVKRRPNEIKKYLTEDQYKLYKLIWERTVASQMKDARYLSTSIDFDNNGYTFRSNGNVVIFDGFTRVYSLNTKDSELPELKDREAISSNEIEPKQHFTKPKPRYTEASLVKTLEEDGIGRPSTYASIISSILSRNYVELKEKKFYTTEIGEKVCEFVVKYFDSIINEKFTAEMENELDNIAENDVEWKKVIRDFYNGFNEDLVNAKNAQDKFKVKDEPIGRKCPECGNDLVIKHGRNGKFIGCSAFPECKYTETIVKDTKVKCPKCGHRIIEKVSKRGKVFYGCENYPNCDFALWDKPTGEKCPECGSLLVHRKNRRGESVLCSNEKCNYKKLEK
(1434) DNA topoisomerase 1 [Acetobacterium woodii DSM 1030]
1
MIKTLVIVESPAKAKTIKKYLPKGFEVEATMGHVIDLPKSRIGINIENNFAPEYIKIRGKAALLKSLKSAAKKADQVYLATDPDREGEAISWHMANFLEIDLTTKCRIEFHEVTKKAVNAAIENKREIDIDLVNSQQARRILDRLVGYSLSPFLWKKVKKGLSGGRVQSVVTRIIVDREEEIEAFIPEEYWNLELLLKKTDDPIEFISKFYSEDGKKKTITIAEEAQRLEKIVDANAIIVDKVKKRIRYQKPPVPFTTSTLQQEAYKVLGYTTQRTMRLAQQLYEGVEIKGSGLTGLITYLRTDSTRIADEAVLESKAYIKQHFGDEYLGSEKKVGKKKNVQDAHEAIRPSSIMLTPEKAKESLEPDQYRLYKLIWERLLCSQMSDAQYYVTDVDIACNNLIFKTKGETQKFDGFTRVNRNPNKSEDSILPELSVGDDLIRLKTTKEQKYTKPPARYTEASLVKILEEKGIGRPSTYAPTIATIKNRDYVEVIEKHFKPTELGVTVTHLMKEYFSDVVNISFTADMEDRLDSVSEGKTDWVELLRNFYGDFEKALTNAQEKAEAVTIADPESDEDCELCGRRMVIKKGKYGRFLACPGFPECKNTKPFFEKTGGICSLCGGDIVKRTSKTGRTFYSCNNYPDCDYMNWDMPIPEKCPVCGSTLFQKGLGKRKSIYCDKKDCGYKAAPKE
(1435) DNA topoisomerase 1 [Staphylococcus aureus subsp. aureus T0131]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKVEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGDITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDCPKCNQYLVENKKGKTTQVICSNCDYKEAAQK
(1436) DNA topoisomerase 1 [Flexistipes sinusarabici DSM 4947]
1
MANVKSNQSPQKKGKNLVIVESPAKARTIERYLGRDFTVMASVGHVRDLPKNELGVEIEDNFTPKYKTIKGKKKIIDALKSAAKEADKIYLATDPDREGEAIAWHIATALKTKADNTYRVQFNEITKQGVNEGIKEPGRINMNRVNAQQSRRILDRLVGYKVSPLLWKPLKYGLSAGRVQSVALRLICEREEEIEKFVPKEYWTLDGYFKKSAGVPESKGEAVKARLEKKNGKKIEIPDEKKVREILNDLENKEAKVADVAKKELRQSPAAPFITSTLQQDANRKLGFTAKKTMMLAQQLYEGISLGSEGPVGLITYMRTDSTRVSSESVKQAKAFITKHFGEKFLGKGRSAKSQKKKAGTQDAHEAIRPTNVDKSPDNIKNFLTNDQYKLYKLIWDRFVASQMAPALFDQSTITITVGDYEFITKGKILKFPGFMKLYVESKENGENNEDSIIYDVEKDEKLEVKNYEEKQHFTSPPPRYSEARLVKTLEQKGIGRPSTYASIISTIIERNYVLLEEKKFRPTELGRIVNKLLISNFTNLFNAEFTAEMEKELDQVESGSKEWVELLNEFYKDFRKELNKAEEKFDADLTIDEKCPKCGKKLIIKYGKNGSFIACSGYPDCRFSCNFERDENGKIRLTDDKNGKSTGLKCEKCGSELVIKQSRCGEILACSAYPDCKNIKSFLRLKDGTLKVIEPGEKLEEKCPKCESELVVKSGKNGIFAACSSYPDCNYTANIKVDEDGNLKPQILKIDTVKCEKCDAEMVLKRSRRGSFFACPNYPDCKNTKAAVTNEDGLVTVKQKKAKSNTE
(1437) DNA topoisomerase 1 [Francisella sp. TX077308]
1
MAKNLVIVESPAKTKTIKKYLGNNFDILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKSAKNAENIYLATDPDREGEAISWHVQEVLKNARLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVNAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFVKKDYWSLTADIFKQKQIFANLTEFDGTKVEQFTFTAEKDAENAKATITKDANGFLIVEGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGMDLGNGESVGLISYMRTDSTNLSNDALNDIRSFIESKFDKDMLPSKPRVFGKKSQNAQEAHEAIRVTSASKTPESMKPYLTTDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENEKHKFRVTGTVIVDAGFLKIYNVEKDEDEKESNDEQTLPKFEKGEKVPLKDIITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQRDYAEVEKRRFIPTDKGRVVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLTVLNSFWKPFIERINKIAEDVSRKDVVQEELDEDCPECGSKLSSRLGKNGRFIGCTNYPTCKYTRRVDSDGKEIEKEEPTVVEDRKCPECGSNLHIKQGRYGKFIGCSNYPTCKHMEPLEKPKDTGVVCPKCNKNNIVEKKSRKGKVFYACSGFPKCKNAYWYPPIKEECPKCKSPILLHKTTKKDGEQKACPNPECDYAVPWEENK
(1490) DNA topoisomerase 1 [Thermoanaerobacter tengcongensis MB4]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASQGHVRDLPKSQLGVDIENNFAPKYITIRGKGEIIEKLKKEAKDAEKIFLATDPDREGEAISWHIAQLLDLDIDKPCRIEFHEITKNAVQAAIKNPRKIDLNLVNAQQARRILDRLVGYKISPILWKKIKRGLSAGRVQSVAARLVCDREREIEAFVPEEYWNITAVLFDEKTSSKFEAKFYGREEEKIELKNREEVDKIINSLSEEYVVYKVKTGTKKRNPPPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGIEIKGEGSVGLVTYIRTDSTRVAKEAKEEAYRYITEKFGKEYANPDAEYSSKKANVQDAHEAIRPTSVFREPEIIKDSLTPDQYKLYKLIWDRFIASQMMPAIYDTVAMDIKNNGYIFKASGSSVKFLGFMTVYVEGSDFQEEEEEKTLPVLKEGTKVRLEELKPTQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTIATLLERGYVVKDKKVLKPTELGFIVTDALKEFFSEIVDVGFTAEMEEQLDKIEEGKVEWYEVVGDFYRDFYKTLKVAEEQMEKVELEEEVEVTDIKCEVCGRPMVVRKGRYGKFLACSGFPECKNTKPLLEKVGVKCPKCGGEIVKRRSKKGRVYYSCENAPQCDFVLWDKPVNEKCPVCGSLMVEKNTKNGIVIKCSNPECGYQKETN
(1491) DNA topoisomerase 1 [Gloeobacter violaceus PCC 7421]
1
MMRLLICESPGKIKTFKAILGAGWDVQASLGHVMELANDGADHLGFDVGPEAITCRYVPRGERGMATLKKLRTAAAKAQEVYLATDPDREGEAIAWHLARELRLKSPRRIRCTQITEGAVRTALQSPGRLDMDLVSAQRARQCLDKLVGYKVSPLLWNATGGKSAGRVQSATLHFVCEREREIIAFVPVDYWSVWVEYAPGWRAYYQGDVQETPESTEATDDAKSNKEAPPAESTRVLSEAEADRLVALARSHPHAVERVERRTVTKIPPAPFTTSTLQQAAGALLSYNPERTMGIAQQLYEGIDLPTGRKGLITYMRTDSVEVAPEFVEQARTYLQINDPDNLPARSATHRSRAGAQQAHEAIRPTDVSLTPRTIRAHLSEEQLRLYDIVWRRAVASQCAPARLAKTKILTRSGPVHWQALGMTVAFAGYTRYWNDLEAALALPALEAGQNLELLRSAHEKKRTQPPPRYSEPKLVQLMERKGVGRPSTYASTIKTLKERAYVELQGRALVPTELGLATDALLGRTLPELVDSAFTARMETGLDAIAASREPWEKYLIGWNTDYLVPAVARARAAIAAEFPKRPAAPRTAQAPQISRTPCPRCRQALSKVPSKKVKRGYFLKCPACADLVMFWNPWRKIWELPKPKTDPQTP
(1492) DNA topoisomerase 1 [Chromobacterium violaceum ATCC 12472]
1
MPTSLLIVESPSKAKTLKKYLGPDFEVLASYGHVRDLVPKNGAVDPEKDFAMKYQLIARNSKHVDAIVSAVREADHVYLATDPDREGEAISWHLVQILNSKKLLKDKTAQRVVFHEITKNAVLDAIQNPRDIAQDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIKAFVQQEYWSVHLDSHKSRTKFSAKLTTLGGKKLDQFDIPNEAEQASVLARLQGLPATVGSIEKKKKSRSPAAPFTTSTLQQEAVRKLGMTTDRAMRTAQQLYEGMDIGQGTVGLITYMRTDSVALANEAVEEIRGYIGLKWDADYLPKNPAVYKSKAKNAQEAHEAIRPTSILRTPEMVKPFLTTDQFKLYDMIWKRTLACQMAPAKFDTTSVDIMVGEGVFRASGQVQTFAGFLAVYEEDVDDAEDEDNAKLPLLTEGEDLPVDKLYGEQHFTQPPPRFSEASLVKALEEFGIGRPSTYASIISTLKDREYVILDKKRFLPTDTGDIVNKFLTEHFAQYVDYNFTAKLENQLDEIANGGRQWVPVMDTFWKGFKKQIDEKESISRAEVTTESLDEDCPKCGKPLSIKFGKRGRFIACTGYPECDYTRNMGETAEQAAEEAEAPTVIEGRSCPDCGGELHIKKGRYGKFIGCANYPKCKHIEPLEKPRETGVTCPECKTGQLIERKSRYGKLFYSCNTYPKCKYATWNPPIAEPCPQCNWPILTIKTTKRRGTEKVCPQKECGYAEQIAPPEGKDAAPAEEA
(1493) DNA topoisomerase 1 [Lactococcus lactis subsp. lactis IO-1]
1
MPTSTKSKTKKTTKKKTTRKRVTPGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIENDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAISWHLAHILNLPLEEKNRVVFNEITKDAVKNAFKEPRQIDVDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPEEYWSIDGEFKKGTKKFKASFWGIDGKKHPLKTNEDVIKVMERLDGPDFNVDKVEKKERRRNAPLPYTTSSMQQDAANKLNFRTRKTMMVAQQLYEGLTLGSQGHQGLITYMRTDSTRISPVAQSAAHNYIADQFGEKYSKHGSKVKNASGAQDAHEAIRPSNVFNTPDAIAKYLDKDQLKLYTLIWNRFVASQMVAAIFDTVKVNLSQNGVIFIANGSQVKFDGYLRIYNDSDKSNMLPEMEENETVKKANVKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLETIQKRYYVRLSAKRFEPTELGEIVNKLIVEFFPNIVNTEFTAEMEKDLDEVEEGKRQWIEVVDQFYKPFAKELENAEEGMEKIQIKDEPAGFDCDVCGSPMVIKLGRFGKFYACSNFPDCRNTKAIVKEIGVKCPLCHEGNIIERKTKKNRIFYGCDRYPECEFTSWDKPIGRDCPKSGHFLVEKKVRGGGKQVVCSNDECDYQEEKQK
(1494) DNA topoisomerase 1 [Niastella koreensis GR20-10]
1
MAKNLLIVESPAKAKTIEKILGKDFEVKSCFGHIRDLEKEEMGIDIKNGYQPRYKVPADKERVVKELKSLANKSDEVWLATDEDREGEAISWHLCEVLGLDPSTTKRIVFHEITKPAIQKAVTSPRLLDMNLVNAQQARRVLDRIVGFELSPVLWRKISARGSNLSAGRVQSVAVRLIAEREREINAFQATSTFKIEALFTTPDITGKNVTFVAEGKKYDTAENAEKFLQTCIGAKYKVNDIQVKPGKKSPAAPFTTSTLQQEASRKLGYGVKRTMTLAQRLYESGNITYMRTDSVNLSDTAMAEIRKQVTGQYGNNYYQPRKYKNKNESAQEAHEAIRPTYMENSTIDDPDCKRLYELIWKRTMASQMADAELEKTIAKIEISTNKEELTASGEVLKFDGFLKVYREDRDEEDITDDEQQEGMLPPLTVNQQLPLNEMKAIERFSRPSPRYTEASLVKKLEELGIGRPSTYAPTINTIQERKYIEKRDKEAVKRNFRILTLKEDKISKVTEQENTGAEKSKLFPSDLGLVVTDFLKQYFDDIMDYGFTARIENEFDEVAAGKLKWNNMIDDFYLPFKKDVDNTIETAERAKGERELGIDPQSGKKITARIGRFGPMVQIGDANEEEKPRFAGLRRGQSIETITLEEALKLFELPKTLGEHEGQEIVVNMGPFGPYIKFGEQNISMPRGIDPNDVNMEKALEFIADKQKADAPIAHYDNKPVTKGTGRFGPFIKWNNMYINVPKKGYDFENLTQDDIDKLIEGKIKKEENRYIQNWPDEKISIENARWGPVLKFGKKILKVGRKADDTKYTAEELVSVPLDDVKKMIEAQVPNAFASKKAAAKKAPGKKAAPKKDATKKKAAPKKK
(1497) DNA topoisomerase 1 [Helicobacter hepaticus ATCC 51449]
1
MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDHMEIVEKIKVASKKAKVTYIATDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITHSLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQRGLSAGRVQSSALKIIVDREREIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAMLEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVETNFGSMGVITYMRTDSLNIAKEAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAIRPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDALFEIQNIIFTPHNQTHLIEFKASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSMESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGLEDKLDEIAQAKMNWESVLWEFYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRKSKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGEPMIKKFGRNGEFIACSGYPKCKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKCPQCGGISVEREYRKKQVRECLKCKHRIEI
(1499) DNA topoisomerase 1 [Bacteriovorax marinus SJ]
1
MKRASPFHLNKDVIMASSEAVEETKSSKKTAKKTAKASSKKKTTKKKTTTSKKKTAKKKTAKTTKKKTTKKRDLGDYSLVIVESPSKAKTIKKYLGKGYQVVASNGHIKDLPKSKLGVDIKENFQIDLVPITGKKDKIERIQELAKDATAIYLAPDMDREGEAIAHHLAEEIGKKKKMYRVVFNAVTKSAVNNAIENPTELNKSMYESQQTRRILDRLVGYKISPILWDKVQRGISAGRVQSVALRIIVEREDEINAFEPEQWFSIHGVCEKDAQKFEVKYYGESATKKTDLTEKDLVDKILSDVKGKSLDVIDVKKKERKQNPTPPFTTSKLQQEAANKLGFTAKRTMMTAQKLYEGIQLTEHGMQGLITYMRTDSVRTAPEAMGALREFILDKYGKDYLSVEPIEYKKKGSSKVQDAHEAIRPTNLAFTPDSVRGDLEPDQQKLYELIWNKFISSQMSQAIIDQTTVMMEREGHFFKANGSIIKFPGFRTVYLEAAAEKRSRKGGDDEDDNDAGEVKSGLLPVINTGESFTPIEGPTEQEHWTSPPPRFNEASLVKSLEEFGIGRPSTYAAIISNIQDRGYVEKTENRFLPTELGIVVCRMLVESFPNVMDIKFTAGVEELLDQIEDGTIKYKKVLKEFWKEFEVTLEKAKEEMKNLKKQLIPTGINCLKCEDGEYHIKWGRNGQFFACSNYPDCNSTQDFKKHLDGSYEILPKNWFHDNCPNCQKRLEVKKGKYGRFVRCEDYPQCDTTLPYTLDITCPECNVGKFAEKKSRYGKIFYGCSNYPNCENASWTKPYVQDCPSCGYGIMGFKETKRDGKHLECAKCKFKLEWEQTKYGKEELEKQRQEEEALKGSH
(1500) DNA topoisomerase 1 [Syntrophobacter fumaroxidans MPOB]
1
MSKSLLIVESPTKAKTLGRYLGKDFIVKASVGHVKDLPKNRLGINLEKDFQPEYQVIRGKKKVISELHEAAAKSGAIFLGPDPDREGEAIAWHIAEEIGATDKPVYRVLFYELTRKAIQEALAKPDRLNRELYEAQQARRILDRLVGYMISPILWQKVKRGLSAGRVQSVALRLICAREKEIRDFDSREYWTITALLGTQASADAPAKSASRRFKAELFRCGKKKCTISTGEEARELVDRLRPLDYRVSKVERRKKKRHPAPPFITSTLQQEAARKLHFSARQTMNVAQRLYEGLELGKEGAVGLITYMRTDSTRLSADAVQAVRDYIAGHWDKAYLPAKPAAYKSKAGAQGAHEAIRPTDVNRTPETVAGFLTKEQLKLYTLIWKRFTACQMAPAVLDQTSVDIAAGDYVLRASGSIVEFPGFMTLYVEGRENGDEDSETEGLLPELKEGEVLRLEDLKADQHFTQPPPRYTEASLIKELEDLGIGRPSTYATILSTILDREYAVVRKKSLFPSELGWLIDGLMVENFPSVVDVDFTAKMEKSLDEIEQGQHPYRNLLAEFYEQFSKTLESARTNMVNLKAVGRRTDLQCPQCGLPLHIRWSRNGPFLACSGYPDCRFSSDYRRDEKGNIEPVAEESTGETCEKCGRPMILKKGRFGNFLACSGYPACKNTKAPGTGIPCPREGCSGELVERVSRGGRHFFGCSRYPECKTAFSGRPVPGKCPSCGTGPLIEKGGKGGSVKRVCVNPSCKYVETVPAAADRKAAKD
(1502) DNA topoisomerase 1 [Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1]
1
MSDYLVIVESPAKAKTIGKYLGSKYTVKASMGHVRDLPKSQLGVDVEHGFEPKYITIRGKGDVIKALREASKKAKKVYLAADPDREGEAIAWHLQHLLDLNPDDDCRVVFHEITKDAVKQAFQHPRKINLDLVNAQQTRRILDRLVGYKLSPLLWRKVKKGLSAGRVQSVALRLIVDRENEIRAFQPEEYWTVDAHGQVHGKKLVARFHGYGEEKTPLPNEEAVRELLARVEGHSLVVRRVRKSERKRNPAAPFTTSSLQQEAARKLGFRAYKTMQIAQQLYEGLDVPGEGTVGLITYMRTDSTRIAQSAQEEARAYIRQSFGEDYVPDRPRQYAKNEDAQDAHEAIRPTSVMRHPDRLKDHLSRDQYRLYKLIWERFVASQMESAILDTTSVDLEANGAWFRATGSVVRFPGFMALYTEGRDDESEEEEGKLLPPLEEGDVVQVKTWKPEQHFTQPPPRYTESSLVKAMEELGIGRPSTYAPTIDILLKRGYVTLDQKRFVPTELGEIVVNILKEHFPQLIDVSFTADMESRLDKVEEGHANWIELLDQFYHDFEKDLKKAESALGHVELKEEVSDVRCEKCGRLMVYKTGKYGKFLACPGFPECRNTKPVLKEISVSCPKCGKPLVERRGKSRKVFYGCSGYPECDYVLWQRPTGQVCPVCGHPMVEKGGKGKTVVVCSNEKAHPMVATEAQAK
(1503) DNA topoisomerase 1 [Agrobacterium vitis S4]
1
MNVVVVESPAKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVLPDQDFEMLWEVDTASAKRMKDIADAMKGADALFLATDPDREGEAISWHVLDLLKKKKVIGDKPVKRVVFNAITKKAVLDAMAAPRDIDGDLVDAYLARRAMDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRENEIERFVSEEYWNLSALLKTPRGDEFLARLVSADGKRLQARSVGNGDMANRLKDLLDGANYVVESIEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIEAARSAITQQFGPRYMPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDQVRRYLDADQLRLYDLVWKRGIASQMASAEIERTTAEILADKAGEKAGLRAVGSVIRFDGFIAAYTDHREEGEKSDDDDEDGRLPEINAREALAKQKVNATQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATLKTLSDREYVVIDKRKLIPEAKGRLVTAFLESFFTRYVEYDFTADLEEKLDKISAGELNWKDVLREFWQNFFAQIEGTKELRVTNVLDALNEALAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNFTRQLSADGGTEAEAVGNEPKALGEDPTTGEQITLRSGRFGPYVQRGDGKEAKRSSLPKGWSPTDVDFDKALSLLSLPREVGLHPETGKMMTAGLGRYGPFVLHDGTYANLDGIEDVLTIGLNRAVTVLAEKQANPGGRGRAAPAALKEIGDHPDGGAITVRDGRYGPYVNWGKINATIPKGMDPQAVTMEEAIALIVERAAKEGSGKTKAKPAAKSASAKKAPAKKPAAKATKADADDAADAKPKKAAAKPKATKPKAKPAAKTEKA
(1510) DNA topoisomerase 1 [Desulfotomaculum ruminis DSM 2154]
1
MSKTLVIVESPAKAKSIGKYLGRNFTVKASMGHVRDLPKSQFGVDIDQEFSPKYITIRGKGDIIKELRSAVKKSDRILLASDPDREGEAIAWHLTKLLDIDEQSPCRIEFNEITKNAIQQAVKNPRPIDQDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREDEIQAFIPEEYWTLMGKFVKSGKSPFEAKLHKYKNKKIEIPNQEMMDKILGDLKGASYQVATVSKKEKQRNPAAPFTTSSLQQEASRKLNFTSRKTMVVAQQLYEGLDLGKEGPAGLVTYIRTDSTRVSETASEEAKKFILDRFGPAYVPKQPRQTVAKGKVQDAHEAIRPTSIERDPENIKQYLTNDQYKLYKLIWSRFLASQMASAVMDTTSLDIAAGDYVFRATGSVIKFPGFMQVYIEGNDDGSKEEERLLPELSEGDKVEAKNLTPKQHFTQPPPRYTDATLVKILEEKGIGRPSTYAPIVDTIQKRGYVVRENKQFYPTELGIVVIDLLKNYFPDIINIEFTAEMEEKLDKVAEGDERWVGILKDFYQPFQETLENADEKIGKVQVADEVTDEKCELCGRNMVIKLGRYGKFLACPGFPDCRNTKPLLEPTGVGCPKCSGEMVLRRSKKGRKFYGCSRYPECDFVTWDVPTQEKCPQCGGMMVEKNSRGKEKRTECINEKCPGKEYKASEQTKKEAGAVSGKTAAKAGKKTPQRNRKKANPSG
(1512) DNA topoisomerase 1 [Methylobacterium radiotolerans JCM 2831]
1
MKVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDGSVDPEQDFRMVWELADRGASRVSEIAKAVKGADKLILATDPDREGEAISWHVLEALTARKALKGIPVERVTFNAITKASVEQAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEARLVGADGKRIQRLDVGTGEEAAAFRRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDARRVIGKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIWTRTMASQMESAELERTTVDVTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLEEQLDRVSNAEIDWRAVLRDFWRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGSNPRTCPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSATGIDGDGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFLQLGEASTEKGAEKPKRSSLPKGLSPSDVDLNKALALLALPREVARHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRLAADPGRPLGKDEASGRDLVVKAGKYGPYVTDGEVNATLPKTMSAEALTLDEAIALVNAKRAAGGGKPAKRGAARKSSARAASGDKPAAKKTATKKPAAKKAATKKSSSG
(1515) DNA topoisomerase 1 [Agrobacterium fabrum str. C58]
1
MNVVVVESPAKAKTINKYLGSGYKVLASFGHVRDLPAKDGSVLPDQDFEMSWEVDSASAKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLKKKRVLGDKPVKRVVFNAITKKAVLDAMANPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFVSEEYWNISALLKTPRGDEFEAKLVSADGKRLQSRGIKTGEDANRLKALLEGATYVVDTVEAKPVKRNPGPPFTTSTLQQAASSRMGFGASRTMQVAQKLYEGIDIGGETVGLITYMRTDGVQIAPEAIDAARLAIGEQFGERYVPEKARFYSTKAKNAQEAHEAIRPTDFTRTPDQVKRYLDADQLRLYDLIWKRGIASQMASAEIERTTVEILADKNGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDDEGRLPQINARENLAKQKINASQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLKTLSDREYIVIDKRKLIPHSRGRLVTAFLESFFTKYVEYDFTAALEEKLDRISAGELDWKQVLRDFWKDFFAQIEDTKELRVTNVLDALNEVLAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNYTRQLTSDGAEADAAASNEPKALGADPMTGEELTLRSGRFGPYIQRGDGKEAKRSSLPKGWKPEDIDHEKALALINLPRDIGKHPETGKMISAGLGRYGPFLLHDGSYANLESIEDVFSIGLNRAVTVIAEKQAKGPGRSGTPAALKELGDHPDGGAITVRDGRYGAYVNWGKVNATIPKGQDPASVTLDESLVLIAERIAKTGTGGKPAKAKKTTAKKADGEAAAKPKATKAKAATKSKAAAKPKAAAKTKKAAE
(1517) DNA topoisomerase 1 [Kosmotoga olearia TBF 19.5.1]
1
MSKKLVIVESPAKAKTIGRYLGKDYEVTSSKGHIRDLPESEFGVDLNSLTPTYRILKGKEKVVKQLKEKAKGKEVLLASDMDREGEAIAWHVAQILGLPKTKKNRIIFSEITENAIKRAVKNPRTIDMNKVNAQVARRILDRIVGYKLSPLLWKTVSRGLSAGRVQTVALKFISDLESKIAAFKPHKFYKIFMRVGEQKIQLLEINGKKFSNKSIRTEEERDKILNELKQSVFVVSSIETTRKKIKPPEPFITSTMQQTAINELGWSASKTMKVAQQLYEGIDTPEGHIAFITYMRTDSTRISEEAKEKAKVFILEKFGEKYLGTAKTKKSRKKNVQDAHEAIRPTYPERTPEEVKAKKLLSGDHLRLYALVWKRFFASQMAAAEYDVTTIKIADENGKYVFKYTTRNCVFDGFERILKKTNGNHETAIVPEGKTIKPDTFLWEEDQTKPPARYTEASLVRELEKKGIGRPSTYATIISTLLERKYVVKSGRELRPTLLGNIVADFLGKSFPDIINEKFTANMEEELDEIENAKRQWKEVVLRFYENFAQDLNKLEQDIKNGKLKIEYPTDRKCDCGGEFKVVFGRYGGYLKCSECGKNQSLDMTVFAPIIEGKVILHDIIETNNKKNELDETCPECGSKLVIRKGRYGSFIACSAYPKCTYTRDIYVDAKCPECGGSVKKMRSKKGKTYFKCVDCGKMFWREPAGKKCEVCGDPLFFKFKRRSKKVLYCEKCKKEFPINE
(1522) DNA topoisomerase 1 [Bacteroides xylanisolvens XB1A]
1
MQKNLVIVESPAKAKTIEKFLGKDFKVLSSYGHIRDLKKKEFSIDVEKNFTPSYEIPADKKALVNTLKTEAKDAETVWLASDEDREGEAIAWHLYEVLKLKPENTKRIVFHEITKSAILKAIEQPRDIDLNLVNAQQARRILDRIVGFELSPVLWRKVKPALSAGRVQSVAVRLIVEREREIHAFQTEAAYRITAVFLVPDTDGKLVEMKAELARRIKTKEEAKAFLNACQGASFAIDDITTRPVKKTPPAPFTTSTLQQEAARKLGYTVAQTMMLAQRLYESGFITYMRTDSVNLSEFATTGSKDAIIKMMGDRYVHLRHFETKTKGAQEAHEAIRPTYMENQSVEGTAQEKKLYDLIWKRTIASQMADAELEKTTATITISGSSDVFTAIGEVIKFDGFLRVYRESYDDDNEQEDESHLLPPLKKGQKLEHGPIIATERFTQRPPRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVEKGNKDGEERQFNVMTLKDRQIKDENHTEITGAEKAKLFPTDTGTVVNDFLTEYFPDILDFNFTASVEKEFDEIAEGEVKWTSIMKNFYDKFHPSVENTLAIKTEHKVGERILGEEPGTGKTVSVKIGRFGPVVQIGTVEDEEKPRFAQMKKGQSMETITLEEALELFKLPRTLGEYEGKSVSVGVGRFGPYVLHNKVYVSLPKTLDPMEITLEEAEQLILEKRQKETERHIKKFEEEPELEILNGRYGPYITYKGSNYKIPKDIVPQDLSLASCLELIKLQDEKGPATTKKGRFAKKK
(1524) DNA topoisomerase 1 [Tannerella forsythia ATCC 43037]
1
MQKKLVIVESPAKAKTIEKFLGKDYRVMSSYGHIRDLKTKEFSIDIENDYAPQYVIPAEKKKLVADLKKASQEATEVLLASDEDREGEAIAWHLAEVLDLNPQNTQRIVFHEITKNAILHALDTPRSLDIHLVNAQQARRVLDRIVGFEVSPILWRKVKPALSAGRVQSVAVRLIVEREREVNDFVAEASYRVIATFILPDGKTLLKAELNRRLKDKDEVDRFLKACREASSEFIIDDISKKPLKKSPAPPFTTSTLQQEAARKLGFSVSQTMMVAQRLYESGFITYMRTDSVNLSSLALNTAKEAIFREYGEKYHQLRKYHTKSKGAQEAHEAIRPTYMDHPAINGNAQEKKLYDLIYKRTIASQMADAELERTTISIGIGKMKDKFLATGEVVKFDGFLHVYRESADDEGEGEQENGLLPAVQVKDVLGVQEITATERFTQRPPRYTEASLVRRMEELGIGRPSTYAPTIQTIQNREYVVRGDKPGEERSFHAVTLKNGTITEAEKKEIVGADRNKLLPTDIGTVVNDFLMEYFPDIMDYNFTASVEKEFDAIAEGELVWTKALDKFYRFFHPIVEKTAAVKTEHKVGERQLGIDPKSGEPVFVKIGRYGPIVQIGLANPNDKQAPKPRFASLMKGQSIETISLEEALELFNLPRVIGTFEDKEMTAAIGRFGPFVRHDNQFVSIPKTLSPYSITAEEAIALIEEKRNKEAQRYIKKFEEEPGLEILNGRYGPYITFDKANYRIPKGVEAASLTLEECKKIIAEADEKPAKRKGAKKK
(1526) DNA topoisomerase 1 [Clostridium acetobutylicum ATCC 824]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIDDNYNPKYITIRGKGELLDKLKKAAKKCDKIYLATDPDREGEAISWHLSKVLKIDESEKCRIEFNEITKNAIKTAIKCPRKININLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMVCSREKLINDFKPEEYWSIDAQVYKQSKKDKFTIRLTSFKGKKIKINNEEENEQIINSIKKDEFKVENVKEGTKNKNTLPPFTTSTLQQDANKKLNFSTKKTMSVAQQLYEGIDVKGHGTIGLITYMRTDSVRVSKEAQEAANDYILNEYGKEYLPPSPKLYKSKKNIQDAHEAIRPTYIELTPGMVKSSLKDDQYKLYNLIWSRFMASQMANCILNTLSIEIKNGEYTFRASGSNVKFEGFMRVYKYNIEEDEHNEKIPLLQKGDLLHTDKIDGKQHFTQPPARFTEASLVKTLEENGIGRPSTYAPIISTLIDRKYVKKEKKAIFPTELGNIVDNILSDYFKQIIDIEFTADMENKLDNVEEGKENWKEIVDEYFKPLKEAIDIAEKEVAKITIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVEKLKVKCPKCGGDVIVRRSKKGRKFFGCSNYPDCDFVSWFEPTEENCPNCGSFMVKKFSKAKGYYLQCSNQECKYEKSNPDPDKK
(1528) DNA topoisomerase 1 [Desulfurobacterium thermolithotrophum DSM 11699]
1
MGKKKLLIVESPAKAKTIQRYLGKDFIVKASMGHVIDLPEKEFGVDIEKDFKPKYVTIKGKDKVLKEIRKAAKESEEVLLATDPDREGEAISWHIANALKRIKKEGIYRVRFHEITKKAIEEAIKNPDKIDENKVNAQQARRILDRIVGYTISPLLSKKFKKALSAGRVQSVALRLICDREEEIRKFVPKEYWTVEGIFRKETSKFPAKLFAVDGKKLDKFDIPDKNSANQLIDRAKKAVFVVTRVERKERKRKPYPPFITSTLQQEASKRFGFPAKLTMQIAQQLYEGIDLGKERVGLITYMRTDSTRVSDEAVKEVRNFIEENFGLEYLPKTKRSYETKTPKSAQDAHEAIRPTSVFRTPESVKKYLTSEQYKLYELIWKRFVASQMKDAVFNTVSADIEGNGLLFRATGSTLKEEGFLKVYPVEFEEKLLPDLNEGDKVEQEDIKGIQHFTEPPPRYTEGTLVKALEEEGVGRPSTYATIISNIIQRGYVEKEKQKLKPTELGEFINDILKKLFPKIVDVKFTANIEEELDKIEEGKKEWIELLKEFYFGEFKELLEKAERELKSLKGEEIGRECPKCGAPLLKIHGKYGTFIACSKYPECKYKESLKGEPKKTGEICPKCGGELVIKNGKYGKFIACANYPKCKYTAPLTYGKCPKCKEGDIVERRSKKGKKFFGCSRYPECDFISNKPPSEAKK
(1530) DNA topoisomerase 1 [Symbiobacterium thermophilum IAM 14863]
1
MPKSLIIVESPAKAKTIEKFLGRKYAVKASMGHVRDLPKSQLGVSVENDFEPKYITIRGKGDILKELRESARKADRVYLATDPDREGEAISWHLAQVLKLPLDEPLRIEFHEITKDAIQRAIKQPRPIDLNRVEAQQARRVLDRLVGYKLSPLLWRKVRRGLSAGRVQSVAVRLIVDREREIQAFQPEEYWTLDARLSTAFAQSFSARYWGMGEQKADLKTQDQVRAVVHQVAGDRLPAGNAAVSGEGTPGDPFTEVLDLAGEGLVLQVRSVKRREKKRNPAYPFTTSSLQQEASRKLGFSVRRTMAVAQQLYEGLPLGEEGHTGLVTYIRTDSTRIADEAARAAAEFIERQYGKDYVPERRREPDRRAGEQGAHEAIRPTDVTRTPESVKPYLTPDQYRLYRLIWERFLASQMAPAVLDTVTVELVAGEHVFRASGQSIRFPGFMKVYIEGEDDDGQREEGDDLLPELAEGQQVTLQTLEARQHFTQPPPRYSEAMLVKALEERGIGRPSTYAPIIGTIQTRGYVEKRDKRFYPTELGVLVTDILKEYFPDIIDVEFTAHLEGKLDEVEEGRVNWRELIRRFYGPFEETLKQAEEKVGGFELEDEVSDVPCEKCGRLMVVKHGRFGKFLACPGFPECKSTKPILEETGVTCPACGTGRIVERKSKKGGRRFYGCTNYPDCNFVSWEKPVNRLCPECGAPYLVEKRIKELGLSHVCKQPDCGYVEPVESMEEVHA
(1533) DNA topoisomerase 1 [Geobacter daltonii FRC-32]
1
MPQHLVIVESPAKAKTIEKFLGPDYKVLASFGHVRALPSKQGSVDIEHDFEPKYAVLPESKKHIDAIKKELKQADVLLLATDPDREGEAISWHLLAALGLDKKPNIDIKRVVFHEITKGAIVNAVENPRGISHELVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFVEQEYWTIGADLSTAGKQNFTANLVEADGKKLGKFDIPGKEAADKLIEILDKATYSVEKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSIAQKLYEGIDIGEGTIGLITYMRTDSVVLSQQALDEAHQVITSLYGKEYALAKPRVFKNKAKNAQEAHEAIRPTYISKTPVELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVEISAGKGYKFRVAGTVIRFPGFMKLYIEGVDDETEEKEGVLPPLNEGDSLQLRDLLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYARLDKKRFFPEDVGMVVSELLVNHFTKYVDYNFTASLEEELDQVSRGEKKWKPLLHEFWQPFHNLLKQKEGEVNKSDLTTEATDEICPECGKPLVVKLGKFGKFFACSGYPECKYIRPLDKDKKESAEPVFSEEKCEKCGSQMLIKEGRFGKYLACSAYPACKNMQPLVKPKGTGIKCVECGEGELTEKKSRYGKMFYSCNRYPQCKFALWDLPVEKPCPKCGFPLLVKKVYKREGEFLKCPKDGCDYKEGGKEK
(1536) DNA topoisomerase 1 [Candidatus Koribacter versatilis Ellin345]
1
MAKGLVIVESPAKAKTIQKYLGKGYEVEASLGHIKDLPKKGLGVDIENNFDTEYVVIPGKEKVVAKLKKLAKDADAIYLAPDPDREGEAIAAHLAEELGDGDGKKKKKTDSKPFYRVTFNEITKKAVQEAFAKPREIDRNLVDAQQTRRILDRLVGFQVSPLLWDKVRRGLSAGRVQTVALRLIVEREREIKAFVSKEYWTIDAHLHGQKPPDFDARFTGIDGEKLEVGNEEESKKIVDQLDNAEWSVRSVDNRERRRNAAAPFTTSKFQQDASRKLGMSVKRAMMIAQHLYEGVELGEEGTVGLITYMRTDSTRVSNEALTEVRELIGTSYGPQFLPESPNVYKQKKDAQGAHEAIRPSSVAHTPDDLKAYLKDDEMKVYKLIWQRFVASQMAPAVFDQTTVDIDAKADRTYNFRVTGSVLKFEGFLKVYEESKEGKDEEDDALKHKLPPLVEGQTLTLKAIKPEQHFTEPPPRYNEASLVKELEEQGIGRPSTYAAILSTIQDRGYVQKTPGRGGKFFPTEIGMVVTDLLVANFKDIFDTKFTSRMEEELDEVEDGQKKWTDTLKEFYDKFETNLDYAQKHMENIKRMEKPTDEKCERCGSPLVIKWGKHGSFYACSSYDKKDPNSCTFTKENPIDLPDLDTADVQETEQEEYCENCGRGMVLKRGRFGQFMACTGYPECKTTRRLDQAKKIPDVPLDEKCPECTRPLVLRHGRFGEFVSCSGYPECKWIKQNFVGVKCPQCKEGEIVEKKARRGNFFYGCARYPKCDFTSANKPVAQPCPKCGSEYVLEKKLKSGTYLTCPNNKATASEEPKRRGKKKAAETENAVKCDYSVKIAEPENTDEPEKSADVA
(1537) DNA topoisomerase 1 [Streptococcus pneumoniae TIGR4]
1
MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNNEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKMALCQL
(1538) DNA topoisomerase 1 [Pelagibacterium halotolerans B2]
1
MKVVIVESPAKAKTINKYLGKDFEVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDTNSKKRLADITRALKGADELILATDPDREGEAISWHLLDALKAKKAIKADMPVKRVVFNAITKDAVTTAMQHPRDIDAPLVDAYLARRALDYLVGFTLSPILWRKLPGSRSAGRVQSVALRLVTEREEEIERFKPQEYWSVIPTLNQTGKSFATRLYSVDGDKTDKLAIKTGEDAQGLKTAIEKGNFKVASVDRKPTKRNPYAPFTTSTLQQDASSRLSLSPSRTMQIAQRLYEDGLITYMRTDAVQMAPEAIEAARRVIGKEFGSEYVPEKPRFYSTKAKNAQEAHEAIRPTDLGKHPDTLRNLDPDQHKIYQLIWRRALASQMRSAEIERTTADIDVLAAGRAITLRATGSVVTFPGFLGVYGVEKTDEDDEDGKDLPALNVGDTPALENVAIEQHFTQPPARYTEASLIKKMEELGIGRPSTYAATLKTLQDRDYIKLEKRAIMPEDRGRLVTAFLQSFFTKYVEYGFTAGLEEELDEISAGEIDYKEVLRRFWKDFSHQADEIKDLRVSEVLDALNDLLGHHIFPERPDGTDPRLCPTCGTGQLSLKLGKYGAFIGCSNYPECRHTQQLAESATGQASEAAQGDGVLGADPETGAEIYLKTGRFGPYVQLGEDAKDAKRSSIPKGWDAGSMDLEKALKLLSLPREVGLHPEDGKPISAGIGRYGPFVLHEKTYANLPDVEEVFTVGLNRAVDLIAQKRAGGGRGGRGAAVAAIQTFEHDDGPITVRAGRYGPYVNQGKVNATLPKDLAPEAVTLEKALELIAAKGGSKSKAKAKPKPAAKKPAAKKTATKKPAAKKKAEA
(1539) DNA topoisomerase 1 [Bartonella henselae str. Houston-1]
1
MNIVIVESPAKAKTINKYLGSQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAAAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDVLRQKKVLKDKPVKRVVFNAITKKSVLDAMNNPRDIDTSLVNAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTDLKTIRNDGFQARLTMFNQKKIGKLDIQSQEQADQIRLMLEKAKYHALSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEMAGLITYMRTDGVQIAPEAIDSARKVIHESFGSDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRIPNQVRNFLDSDQAKLYELIWKRAVASQMRSAEIERTTVEIEAQQGENYANLRATGSVIRFDGFLSLYTDQRDEENNEENETTRLPQINTGEELTKEKVDAIQHTTEPPPRYSEASLIKKLEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRDFWDGFNASITNIQELRITNVLDVLNVTLAPLAFPVREDGSDVRSCPLCTNGQLSLKLGRYGAFVGCSNYPECKYTRQLGTDPGEENEAIRNDEPVILGVDPKTGKDVTLRNGRFGPYIQLGESKEAKRAGLPKEWQAEKITLEKALSLISLPREIGIHPETGKTITATIGRYGPYLTHDGKYAPLLNVDEVFDIGINRAVTVLAEKQENKTKRSRTTTAALATLGNHPDGGVVTVRNGRYGPYVNWGKVNATLPKDKDPINVTLSEALELISVKASGKKTTLKRASTKTKET
(1542) DNA topoisomerase 1 [Bartonella grahamii as4aup]
1
MNIVIVESPAKAKTINKYLGSQYKVVASFGHVRDLPAKDGSVLPDRDFSMKWDIDSSAAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDVLRQKKVLKDKPIKRVVFNAITKKSVLDAMNNPRDIDTSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSVTTQLKTIRNDSFQARLTMFNQRKIGKLDIQSQEQADQIRFMLEKSQYHTLSVEAKPTKRNPLPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGETAGLITYMRTDGVQIAPEAIDSARKVIHETFGKDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRNPSQVRNFLDSDQAKLYELIWKRAIASQMRSAEIERTTVEIEAQQGENRANLRATGSVIRFDGFISVYTDQRDEENNEENETTRLPQVNTGEALTKEKVESVQHTTEPPSRYSEASLIKKLEELGIGRPSTYASTLATLCDRGYIVIDKRKLIPDAKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRDFWDGFNASISNIQELRITNVLDVLNVTLAPLAFPEREDGSDVRSCPLCKNGQLSLKLGRYGAFVGCSNYPECKYTHQLGTDTGEENEAVRNDEPVILGIDPETGKDISLRNGRFGPYIQLGESKEVKRAGLPKEWQAENVTLDKALALLSLPREIGVHPESGKTITATIGRYGPYLSHNGKSARLLHADEVFDIGINRAVTVLAEQQENKTKQSRATPAALAILGEHPEGGTITVRNGRYGPYVNWGKINATLPKDKDPISVTLPEALELISAKASSKKTTSKRASSKTKAKIKET
(1546) DNA topoisomerase 1 [Selenomonas sputigena ATCC 35185]
1
MPTAQKKTPQEKNREVVGQAEKKEGKRAAGKGAAKTAAVEKPAAKKSAVKKASAKKTATKKSAARDSTATTSAAEKKPAAKKSAPKKTVAKKTVAKKTVAKKTAAKKTAAKKEAPQTLVVVESPAKAKTIEKYLGKKYMVRASMGHLRDLPKSQFGIDVENDFAPKYINIRGKGDLIKALKKDAKHAAKVYLASDPDREGEAIAWHLAHILGIDPNENCRIVFNEITKPAIQAAVKEPYPINLDRVDAQQARRMLDRIVGYKLSPLLWRKIKKGLSAGRVQSVTVKLICDREKEIQAFVPEEYWTVGMKLKKGRGAQFAAELATVDGKKLALHSKEETSALVKDMAKQSFSVKEVKKRERRRNPVAPFTTSSMQQDASRKLGFTSRRTMMIAQQLYEGVELGRRGPVGLITYMRTDSTRLSDLALDEVRGYVGTSFGADYLPEKPNIYAAGKKAQDAHEAIRPTSVENTPELMEKYLSREQLRLYTLIWQRFVASQMTPAVFDTVSVSVAAGERYIARASGSTLKFPGFLAVYADNKKEKDVLLPELAAGEALSLLDLLPEQHFTEPPPRYNEASLVKTLEEEDIGRPSTYAPIIETILARGYVVRQDKHFQPTDLGFLVNDMLEEHFKDIVDVQFTAGLENELDEIAEGKVDKNDLLRGFYEPFEKTLEEADEAIGEVEIPEEVSDVICEKCGRNMVVKQGRYGKFLACPGFPDCRNTKPLLKDTGVPCPKCGGRIVERRSRRGQAFYGCENYPACDYVTWDQPLTEKCPECGAFMLRHRYKNGRILPYCSNEECKTRIDHPINKEIEKSRARLEAKKAKEAAAAEKAAEAEATT
(1547) DNA topoisomerase 1 [Selenomonas sputigena ATCC 35185]
1
MPTAQKKTPQEKNREVVGQAEKKEGKRAAGKGAAKTAAVEKPAAKKSAVKKASAKKTATKKSAARDSTATTSAAEKKPAAKKSAPKKTVAKKTVAKKTVAKKTAAKKTAAKKEAPQTLVVVESPAKAKTIEKYLGKKYMVRASMGHLRDLPKSQFGIDVENDFAPKYINIRGKGDLIKALKKDAKHAAKVYLASDPDREGEAIAWHLAHILGIDPNENCRIVFNEITKPAIQAAVKEPYPINLDRVDAQQARRMLDRIVGYKLSPLLWRKIKKGLSAGRVQSVTVKLICDREKEIQAFVPEEYWTVGMKLKKGRGAQFAAELATVDGKKLALHSKEETSALVKDMAKQSFSVKEVKKRERRRNPVAPFTTSSMQQDASRKLGFTSRRTMMIAQQLYEGVELGRRGPVGLITYMRTDSTRLSDLALDEVRGYVGTSFGADYLPEKPNIYAAGKKAQDAHEAIRPTSVENTPELMEKYLSREQLRLYTLIWQRFVASQMTPAVFDTVSVSVAAGERYIARASGSTLKFPGFLAVYADNKKEKDVLLPELAAGEALSLLDLLPEQHFTEPPPRYNEASLVKTLEEEDIGRPSTYAPIIETILARGYVVRQDKHFQPTDLGFLVNDMLEEHFKDIVDVQFTAGLENELDEIAEGKVDKNDLLRGFYEPFEKTLEEADEAIGEVEIPEEVSDVICEKCGRNMVVKQGRYGKFLACPGFPDCRNTKPLLKDTGVPCPKCGGRIVERRSRRGQAFYGCENYPACDYVTWDQPLTEKCPECGAFMLRHRYKNGRILPYCSNEECKTRIDHPINKEIEKSRARLEAKKAKEAAAAEKAAEAEATT
(1550) DNA topoisomerase 1 [Enterococcus sp. 7L76]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQKNGLKLSIASTSPSKKN
(1552) DNA topoisomerase 1 [Ehrlichia canis str. Jake]
1
MSLIIVESPSKAKTIGKYLGSKYKVVASFGHIRDFPAKSGSVNPDKDFAMTYEIISKSEKYVNKLIQVASKETHGIYLATDPDREGEAIAWHIVEVLKENNAIDDNVVINRMVFNEVTKNAILESIKHPRSINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRESDIEKFVTQEYWDIEAKCQNVEGKQFSAFLSYYAGKKLEKFDIKNEEDAKRLAEEVKSRNYSVVKVEKKHTKRNPYPPFITSSLQQEASTKLGFTAKNTMLIAQKLYEGIDVGGEIVGLITYMRTDGFYIADEALDHIRSIIVSIFGKEYLPASARKYVKKVKNAQEAHEAIRPTNITITPDSLSNYLTPEQLKLYDLIWKRTVASQMNSAIIDQVVVELASSDKVVTLRATGSSLFFDGFYKVYGHNEDDDNKNNMLPLLQVSDECPLNEVIPHQHFTIPPARYNEASLVKKMEEIGIGRPSTYASIISVLQDRQYVILNQKKFFPTERGRIVNIFLVNFFSRYVEYDFTADLEEELDLISNGKINWKKVLHKFWFLFIDNVNSVKKLEFTEILKVISCEMENYIFSSDKSETGRVCPACNDGTLGLNISKNGIFLGCSGYPECKYTKNVGGDLVDDVDNVQYPKVLGIDTATCQEIYLKKGPYGVYLQIGSDKNGKRAAIPKNMNANLLDLQMAEKILNLPISLGTHPETCKEIKLGLGKFGAYILYEGKYFSIKNESNFLDVKLEDAIDIIANSSTNGVIRSLGISEDNKEVLLCKGRYGFYLKYDKLNVALKKGTDVEQMSLSDAMKLISEKK
(1553) DNA topoisomerase 1 [Mycoplasma crocodyli MP145]
1
MSKFLVIVESPNKVATIKKYLGNDYDVEASVGHIAKMKTSGPYGLGIDFENWEPLYSLESGKKELIKKLKDLAKNAEWVYISTDPDREGEAIGDHLVQYLKISDKYNRIKYNEITKDAILQAISKPANLDEDLVNAQKARRMLDRIIGFRLSQLMKQKLVNTPTNPSAGRVQSIALKLVIDRENEIEAFIPEDYYKLEAHLGQELIANYINMENTSDKRDWIFPNQIDGYKTFFTNIKNNTLTVSSVDVSEKRVGSVTPFKQAVLYRRSQYNSSITQSAAQKLYEGYGDGGLISYPRTDSTRLSQTFIDNARKYVLDKWGQEYIASDVKGFSGDQDAHEAIRPTDLHLTPEIAKAKYSEMTDYEYNVYKLIYINTLQAIMTRPLRVNKSYTLLIDKYTFKMNFSTVKFDGYYVITGQYDQDNNDPNYEINQKIKVNEYKFSDHQTKPRPRYTEGSLIEALDEIKVGRPSTFATTVKILKDREYVINEASALKPTEFGKSVLEKLIFSFSNIINESYTALVEEQLDLIAENKLSKEPVMQDFWQRFDETMNEAINTMERTVLLPISLDEKCPEDAADLLVKRNRKGQKFAGCANYPNCTYTKSIEKPRGFFRKKAV
(1557) DNA topoisomerase 1 [Myxococcus fulvus HW-1]
1
MATRTKKKVEETEAAEEKAPAKKAAAKKKPAARKKTVAKKKTAARRRTKKGDEDALPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREGEAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQISPLLWKKVRRGLSAGRVQSVAVRLIVEREEEIKAFVPEEYWTLDALLEGPSGPPPFKAKLSKVDGKKVELKDRATTEGLVAELQSASFSVAKVDRRERRRNAPAPFITSKLQQEAANRLSFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFLPDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKGFFEAMGEEDMYRLYELIWNRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEGADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVMVEEETTDELCEKCGKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRDGPYVACPNKECDYRREITEQPAGPGGSPEASSAA
(1558) DNA topoisomerase 1 [Bdellovibrio bacteriovorus HD100]
1
MAKKSDATDGIKLVIVESPTKAKTIRKFLGRDYVVESCMGHIRDLPQSAKDIPEKVKKEKWAQLGVNVDKNFEPLYCVPKDKTKVVKNLKDKLEEASELYLATDEDREGESISWHLLEVLKPKVPTKRMVFHEITKDAIQKALKDTREIDFNLVRAQEARRVLDRLVGYTISPLLWKKVAYGLSAGRVQSVAVRLIVERELERVRFKKSSYWGVLAELSKDGVSFESRLQQYKNQRVATGKDFDGLTGQLTAGKDVLVLDEKTAGKLSMDLKSGNWQVTDVEEKPTFRKPAPPFITSTLQQESNRKLGLSSRETMQVAQKLYEQGFITYMRTDSTFLSNEAITASRDCIESKYGKEYLTPQPRNYAAKKVKGAQEAHEAIRPAGNQFMDPDETGLTGTQFRLYDLIWKRTIASQMVDARQKQVSAKITVGDALFGASGMTIEFPGFLRAYVEGSDDPEADLAEREVRLPALKVKDGVKCAKLDPTSHETKPPARYTEASLVQTMEKEGIGRPSTYASVIGTIIDRGYVRKNGTALVPTFTAMIVSKLLSQYLSQYVDLGFTSEMEQSLDNIADGELDWESYLASVYKGPKGLRAMVDNQGDKIDPNEARTMTLEGMDKYKFHVGRYGAYVTTQRDGEDVSASLPDNESPADITPEIAEKLIDQKINGADSLGNDPETDLPVYVLNGRYGPYVQLGDVTPEDDKPKRASLPPGTQPEQVDLAMALSLLQLPKTLGTHPGTGKDIKAGLGRFGPFVVHDGDYRSIPKGESIFNITFEKAMEMLAQPKKGRGRAAPLKELGAHPDSGDAIQVFNGPYGPYIKCGKVNASLPEGATPDTVTLEQAVALINEKGPAKGKGKAKGKAKAAPKAKAAKADGEKPAAKKPALKKAANAKEKAEALGVKKVVTRKSKK
(1560) DNA topoisomerase 1 [Brucella abortus A13334]
1
MGREFRLLYMNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEILRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGRDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEQITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1561) DNA topoisomerase 1 [Streptococcus mutans UA159]
1
MTSKTTTTVKKTSKKRATPKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKNAKQIFLASDPDREGEAISWHLAHILDLDLKGKNRVVFNEITKDAVKNAFVEPRQIDMDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWSIDGFFKKGNKKFQANFYGLDNKKTKLKSNDDVKKVLTRIKNDDFLVDKVEKKERKRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIRLGSNGQQGLITYMRTDSTRISPVAQNDAANYITEHFGAEYSKHGNHVRNASGAQDAHEAIRPSNVNHTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLTQNGVLFIANGSQIKFKGYMAVYNDSDKTKVLPEMIKGETVKKISANPEQHFTQPPARYSEASLIKTLEENGVGRPSTYAPTLETIQKRYYVRLVSKRFEPTELGEIVNSLIIEFFPDIVDVKFTAEMESKLDEVEIGKEEWQKVIDQFYKPFEKEVIKAEEQMEKIQIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVICPICQKGQVIERKTKRNRIFYGCDRYPDCDFTSWNKPIGRDCPKSGDFLVEKKIRGGGKQVVCSNEECDYKEKAVK
(1564) DNA topoisomerase 1 [Caminibacter mediatlanticus TB-2]
1
MAKKLIIVESPSKARTIKNFLGKEYEVIASKGHIRDLPKTSFGIKIEEDKFIPQYRVTKDHQSVAKELKEKAKKAETIYIATDEDREGEAIGFHIAHVIGKDPSSLPRIVFHEITKTAIKNALKNPRKLDIDRVNAQQARRLLDRIVGYKLSPLLNKKIQKGLSAGRVQSAALKLVVDREREIKEFIPKEYWSIEGIFKEVEGNLIKYNGKKLEKFDLKTRDEAEKIVNELKPLEYEVSKIEKKTTTTKSPAPFMTSTLQQVASSELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQEAAINFIKENIGSEYAEAKTYTTKNQTAQEAHEAIRPVDVRLTPDDLKNYLSKDELKLYSLIYNRFLASQMKDAKFETQNIYLTNEKGEFKISGKKLIFDGFYKVYGKRGADTLLPEFKEGEKLKPEEIKATQHFTKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEIKDKKLHPTEIAFNVIETLEKHFPDIVDAKFTANMEEMLDEIARGNKDWQEMLKEFYNPFMKLIEKGYEEIPSQKIAKPTGELCPECGNPLVIRKGRFGEFIACSNFPKCKYTRPIEEKEEKKVDVKCDKCGADMVIKRGKRGEFLACSNYPECKNTKPLNPPEVLEDVKCPECGGDIIKRKSRRGEFYGCGNYPKCNFISKYRPVNEKCDECGYMMAKRTYRNKEVLECIKCKARKEI
(1566) DNA topoisomerase 1 [Chloroherpeton thalassium ATCC 35110]
1
MPAKKSTTGNVGSAKGKKLVIVESPSKAKTINKYLGKDFAVYASVGHIKDLPKKEIGLDFEHHYEPRYEVIEGKEKVVREMKKLAGEADEIMIATDPDREGEAIAWHIANEVSGAKKPIRRVLFNEITARAVKEAIQETRDIDYSLVRSQQARQAMDKIVGYRISPFLWDTVLRGLSAGRVQSVALRLICEREAEIDAFETKEYWSILADFTTESGEKFTAKLVKQNGKDIEIPNEAEAKRLLDLLNARLYAISEIRRRKTKRNPPAPFTTSLLQQSASNRLGYGSKKTMSLAQQLYEGIEIGSEGAVGLITYMRTDSKRISQDAQEEARKFIQQAFGEDYTPEKPKQYKTSEKAQDAHEAIRPTSVFRKPSDLAPFLSKDQLRLYELIWKRFVASQMSPAELEQTGVDISDHEKEFIFRASGSVVLFDGFLKIFGDQRELDYEERKSTKEEASEEDAPTKLPKNLKEKESLTLDALKENQHFTKPPARYSEASLVKELDNYGIGRPSTYASIISTLLDRKYVELRQRRLNPTELGKDVSRILIANFPELFNVTFTAGMENNLDKVAAGDDDYESLLDNFYKPLEETLGVRKANPILPQNENAEVCDKCGEGRMVVKWTKSGKFLGCSRYPKCKNIKPIAVEKPKPVETGIKCSKCESGRMVVREGRFGKFLACTNYPECESLLNINKKGQVEPPKVPPLTTELACPNCGAPLYLREGKRGLWLGCSKFPKCRGRKSWNDLDDETRAKLEAAHSANLAKHPPVEIKMLDGSPLNLNAKLEDLISNASDFVKGIEESAEAEIDS
(1574) DNA topoisomerase 1 [Flavobacterium branchiophilum FL-15]
1
MAKNLVIVESPAKAKTIEKFLGADFQVESSYGHIADLPSKEIGVDVEDGFKPRYEVSADKRALVAKLKALSKKAEMVWLASDEDREGEAISWHLAEELKLDKKKTKRIVFHEITKNAILKAIDNPREIDYNLVNAQQARRVLDRLVGYELSPVLWRKIKGGLSAGRVQSVSVRLIVEREREIQNFVAVASYSIVAEFVNQAGKSFKAKLPKNFATQKEAEDFLNQNSNSNYTIADIETKPTKKSPAAPFTTSTLQQEAARKLYLPVGITMQLAQRLYEAGLITYMRTDSVNLSQEAMNAAQAEIIKSYGKDFSKPRVFANKSKGAQEAHEAIRPTDMSRHTVAIDRDQARLYDLIWKRTLASQMSDAQLERTNVKIIADNHKEYFTASGEVLLFEGFLKVYLEGNDDDDEEQEGMLPALRVNESLNNQYITATERYTRPAARYTEASLVKKLEELGIGRPSTYAPTISTIINRNYVEKGNLEGQERIYNQMTLKAGKISAKILKENTGSDKGKLVPTDIGTIVTDFLVKNFGNILDYHFTAKVEQDFDEIAEGNIEWAKMMKDFYDKFHPNVKDVEANADRESGERVLGIHPESGKPISVRLGKFGPMAQIGHADDEDKKFASLNKDQNIGNITLEEALNLFLLPKILGNYKDEEIEVSNGRYGPYVRHGAAFISLPRGENPLDVTFERAKTLIDEKALADAPIATYKGENVQKGTGRFGPFIKWNGIFINVSKKYDFDRLSQADVEALIEDKLQKNIDKVIHHWESEGILVEKARWGRSVITKGKIKIELSKDIDASKLTLLQVQEMIAAKTPVKKTPVKKAPANKSTTTKATTTKKTVSKKK
(1578) DNA topoisomerase 1 [Aminobacterium colombiense DSM 12261]
1
MTKKESGKTLVVVESPTKAKTLSKILGSKYTVKASIGHIKDLPKSRIAIDVENNFQPEYILVKGKAKIKNELVKLARGSQKILLASDPDREGEAIAWHLCNILDVDPQTLCRIRFYEVTPKAVKEALKKLEPVDMNRVNAQQARRVLDRLVGYTLSPLLWKKIRYGLSAGRVQSVALNLICEREREIISFVPSEYWHISVLASSLDKTRNYDLKVMSFKNKSFWKEGKPLLISSSEQAEKIASDIAKQELVVKEYKVKEGKRAPLPPFKTSTLQQEAARRLGFSPRRTMRIAQSLFEGVSVPGRGPVGLITYMRTDSLRIAPDAINGARTFISERYEAKYLPAKPNFFASKARSQDAHEAIRPTDVTLTPEILKNVLNSEQHRLYTLIWNRFVASQMASALVANAILDVAAGSYGLRQTGESLIFDGWGAVWPLELKGGQLDPAQPEETLLCQEIEKEQRFTKPAARYSEATLIKTLEEKGVGRPSTYATIVETLYDRGYVEKNEEKRIEPTQLGMTVDDFLLQYFDSKSQSPIVDTGFTAQMEEQLDLIEEDQLQWVEVVRSFWNGFTNTLEEAKKASAVELPEPEPIGEDCPECGKPLVKKRGRFGEFIACSGYPECRYTKPILKTIGVKCPLCGETEGGEVVRRRSKKGKFFYGCSRYPECKYVSWNEPTGEKCKECGASLIRKNKKSLPECPECGWKKEKKGKKENK
(1584) DNA topoisomerase 1 [Anoxybacillus flavithermus WK1]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIQNDYEPKYITIRGKGSVIKELKTAAKKAKKVFLAADPDREGEAIAWHLAHLLDLNTESPCRVVFNEITKDAIKQSFEQPRAINMHLVHAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIQSFQPEEYWTIQGTFMKGNDTFEAQFYRLGSEPFDLKTEQDVQHVLNHIQGNEFVVTAVTKKERKRNPVAPFITSSLQQEAARKLNFRTKKTMMVAQQLYEGIDLGSEGTVGLITYMRTDSTRVSESAQQEAIQYIEQTFGTSYVATEKRKEKQKANAQDAHEAIRPTSVWRHPSAIKPHVTRDQYQLYKLIWERFIASQMAPAVLDTVAIELSNGSVVFRATGSTVKFPGFMKVYVEGTDDPKDEQQRLLPDFVEGERVFSKDIEGKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVTLENKRFVPTELGEIVLDLMMQFFPEILDVEFTAKMEKSLDDIEEGKVEWVRIIDEFYREFEKRLKIAEVEMEKVEIADESADVDCEVCGSPMVYKMGRFGKFIACSNFPQCRNTKAIVKDIGVKCPRCHEGNIVERKSKKKRMFYGCDRFPTCDFVSWDKPINRPCPKCGGMLVEKKGKKSVHIQCTQCEYNEQQ
(1589) DNA topoisomerase 1 [Thermobaculum terrenum ATCC BAA-798]
1
MANKLVIVESPTKAKTISRYLGRGYSIKASMGHVRDLPKSKLGVDTEHDFQPQYLIPRDKSKTVKELKESVASAREVYLATDPDREGEAIAWHLIQATGMDTSKARRVVFHEITPDAVRNAMANPREIDMRLVDAQQARRVLDRLVGYNISPLLWKKVKRGLSAGRVQSVALRLVVDREREIQSFVPVEYWTISADLAKQPAKGRKPSRKDQFRALLVRINDEKVEISNEEQARAIIEALEGATYKVLEVKQREIQRKPAPPFITSTMQQEASRKLNFNARRTMSVAQSLYEGVSLGDEGDVGLITYMRTDSTNVATVAQEEARQVIAQLFGDKYLPEKPPVYTKKAKNAQEAHEAIRPTSVKRHPDAIKQYLTSDQYKLYKLIWQRFIASQMANAIIDGTTVDIAAEPRSGGAPYIFRATGSVIKFDGFLVVYQEGKDDDQEEELGSKALPPMTEGEVLNLIQLLPEQHFTQPPPRYTEASLVKALEEQGIGRPSTYAIILSTLQERYYVVKDGKALVPTELGMLVNDLLVEHFPDIVDVNFTSQMEEELDDIASGERAWVPVIKEFYGPFERKVRIAEEEMQKVDIQDEPAGENCPNCGRPMVFKMGRYGKFIACSGFPECRTTKAIVNRTGVQCPACRQGELVERRSRKGRRSIFYACDRYPDCEFTISAKPLPQPCPACGGLQVEDGKNGQKCIRCDGQGNILQKSA
(1592) DNA topoisomerase 1 [Ehrlichia ruminantium str. Welgevonden]
1
MSLIIVESPSKAKTIGKYLGSKYKVVASFGHIRDFPAKSGSVDPDKDFAMTYEIIAKSEKYVSKLVQVANKETKEIYLATDPDREGEAIAWHIVEVLREKNAINNNIVINRMVFNEITKNAILASVKNPRNINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRENEIEKFITQEYWDIEAKLQNVEGREFSAYLKCYSGNKLEKFDIKNEEDANRLSAEIRQRSYSVSSVEKKHTKRNPYPPFITSSLQQEASTKLGFSAKSTMLIAQKLYEGVDIGGEIVGLITYMRTDGVYISDEAVEHIRSVISSMFGKEYLPESPRKYVKKIKNAQEAHEAIRPTNITITPDSLVSYLTQEQLKLYDLIWKRTVASQMNSAVLDQVIVELSSLDGIVILRALGSSLSFDGFYKVYGHDDDSKNSILPLLNENDHCPLNDVIPNQHFTNPPARYSEASLVKKMEEIGIGRPSTYASIISVLQDRQYVVLNQKRFFPTERGRVVNIFLVNFFNRYVEYDFTADLEEKLDLISNGKIGWKEVLHQFWFLFIDNVNSVKKLEFTQILNAISSEMESHIFPSDVSEVDKMCPVCNVGTLSLNISKNGVFLGCSQYPECKYTKNIGDSTVDNTEVSQYPRVLGSDAASGEDIYLKKGPYGIYLQIGSGKDGKRATLPKDIDLNLLDLEMAKKILSLPISLGMYPDTNSEIKLGLGKFGAYIFYEGKYFSIKKFEGNFLDITLENAIAIIQKNRTNGVIKSLGMSQDNKEVFLCKGRYGFYLKYDKLNIAIKKGIDVEQMSLVDALKLISEKL
(1593) DNA topoisomerase 1 [Ehrlichia ruminantium str. Welgevonden]
1
MSLIIVESPSKAKTIGKYLGSKYKVVASFGHIRDFPAKSGSVDPDKDFAMTYEIIAKSEKYVSKLVQVANKETKEIYLATDPDREGEAIAWHIVEVLREKNAINNNIVINRMVFNEITKNAILASVKNPRNINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRENEIEKFITQEYWDIEAKLQNVEGREFSAYLKCYSGNKLEKFDIKNEEDANRLSAEIRQRSYSVSSVEKKHTKRNPYPPFITSSLQQEASTKLGFSAKSTMLIAQKLYEGVDIGGEIVGLITYMRTDGVYISDEAVEHIRSVISSMFGKEYLPESPRKYVKKIKNAQEAHEAIRPTNITITPDSLVSYLTQEQLKLYDLIWKRTVASQMNSAVLDQVIVELSSLDGIVILRALGSSLSFDGFYKVYGHDDDSKNSILPLLNENDHCPLNDVIPNQHFTNPPARYSEASLVKKMEEIGIGRPSTYASIISVLQDRQYVVLNQKRFFPTERGRVVNIFLVNFFNRYVEYDFTADLEEKLDLISNGKIGWKEVLHQFWFLFIDNVNSVKKLEFTQILNAISSEMESHIFPSDVSEVDKMCPVCNVGTLSLNISKNGVFLGCSQYPECKYTKNIGDSTVDNTEVSQYPRVLGSDAASGEDIYLKKGPYGIYLQIGSGKDGKRATLPKDIDLNLLDLEMAKKILSLPISLGMYPDTNSEIKLGLGKFGAYIFYEGKYFSIKKFEGNFLDITLENAIAIIQKNRTNGVIKSLGMSQDNKEVFLCKGRYGFYLKYDKLNIAIKKGIDVEQMSLVDALKLISEKL
(1595) DNA topoisomerase 1 [Simkania negevensis Z]
1
MAKGKGKTLIIVESPTKVKTLKKFLGNDYHVESSVGHIRDLPKKGFGIDIDNDFEPVYENLPDKKEVISKLKKTAQECDTVFLSPDPDREGEAIAWHIAAILPKGPNVKRVTFNAITKDAVTEAIKHPRDIDLSLVDAQQARRLLDRMVGYKISPLLQRRIKRSGSGSLSAGRVQSVALKLVVDREKEIEAFVPVEYWNIGAILRPKPKERAFPAALYAVDGKKVEKELVKGKDFCTVSNEIEAKKITAALKHSIYTIQKVEKKEKKRHPVPPFITSTLQQEASRHYGFSAQRTMSIAQSLYEGVDLGKEGTEGLITYMRTDSVRIEPEAISAARKLIDGAYGKEYLPPKPKQYSTKKSAQDAHEAIRPTNLNHPPDVIKSSLNIDQYKLYLLIWRRFLASQMNPAIYDTVSCHIETDQKMSLRAVGSIIKFKGFLAVYEEKEDTEEDQPPQEEENLLPDLEEGKTLELIEVTSAQAFTKPPPRFTEASLVKELEKSGIGRPSTYASIMNKIHSRAYTTKERLALKPTELGKIIAQMLEAHFTMIMDIEFTAKMEDELDDIAESKKNWKEFVGGFWEKFVPVMEKAEKEAFVPKIMTDINCPKCGHKLQKIWARDKYFYGCSNYPDCKFTVPIEALEFNKDEYAEDFDWDQPCTKCSSPMQIRFSRFGAFLGCSRYPDCNGIVNIPKKGEIIPDDLPNCPAVGCDGQIKARKSRWGKTFFSCSNYPDCDVIVNEVDQLEVKYQDHPKTPYQKKTKKGGKRAGGSGRAKKLSKELQAVVGEKELTRGEVTKKIWEYIKSHNLQDPSNKRLIVPDEKLEKVFGNSEPLDMFKLAGVLGKHID
(1596) DNA topoisomerase 1 [Methylomicrobium alcaliphilum 20Z]
1
MSNNLVIVESPAKAKTIEKYLGKDFHVLASYGHVRDLVPKEGAVDPEHDFAMKYEIIERNQRHVQAITKAIKQAQALYLATDPDREGEAISWHLYELLKDKKLLKDKPVHRVVFHEITKKAVTEAIAHPAELSIDLINAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSREYWTIDAELSAEEQAFKAKLTHFEGEKVEQFTIDNEERALQVKQTLFDAADGKLLVAKVEKKQRKRNPAPPFITSTLQQEAARKLGFTTKRTMMVAQQLYEGIDIGGETVGLITYMRTDSVNLAAEAIAEIRELIAEKYGAKNVPKSPRDYKTKSKNAQEAHEAIRPTSARRIPVELQKFLSPEQFKLYDLIWKRTISSQMVHATINTVAVDLHCGSERNVFRATGSTIADPGFMAVYLEGKDDTAEGDDKENFLPSLEEGRPVPLNDIIAGQHFTEPPPRYSEASLVKALEEFGIGRPSTYASIISTLQNRDYVTLESKRFYPTDVGRIVNKFLTEHFNKYVDYDFTANLEDELDAVSRGEKDWIPLMRSFWEPFNTLIHEKEESVQRKDVTQEAIDEKCPECGSPLSIRLGRNGRFIGCTNYPECSYTRNLNEDASKSSEPEVVEGRVCPKCESPLVIKTGRYGKFIGCSSYPKCKHIEPLEKPVDTGVECPQCKKGNLLKRKSRNGKIFYSCSEYPKCSYAIWNAPVQENCPECNWPILTLKTTKRRGTEKVCPQKECSYATPYEGDPDDVLGPKG
(1597) DNA topoisomerase 1 [Nostoc sp. PCC 7120]
1
MSTLVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASEIPASVKGEAWAQLGVNVDADFEPVYVVPKDKKKVVTQLKEALKDADELILATDEDREGESISWHLFQLLKPKVPTKRMVFHEITQEAIKKALKDCRNIDEQLVRAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVTKERQRRAFHEGTYWDLKAYLEQSKSPFTAQLTTLAGTKVATGSDFDASTGRITAGRNVVLLSETEAVALQERLTGKPWNVSEVEERPVTRKPAPPFTTSTLQQESNRKLRLSARDTMRIAQNLYEQGYITYMRTDSVHLSEQAIAAARNCVEQLYGKQYLSPQKRQYTTKSKGAQEAHEAIRPAGSTFRTPQETGLGGRELALYDLIWKRTVACQMADSRQTQITVQLQVEDAGFRASGKRIDFPGYLRAYVEGSDDPEAALEDQEVILPSLKVGDHPDCQNIEAVGHETQPPARYTEATLVKTLESEGIGRPSTYASIIGTIIDKGYSQLVNNALIPTFTAFAVTDLLEKNFPDIVDPSFTSKMEQTLDDIADGEVEWLPYLKKFYLGDKGLETLVRERESLIDASKARTVELENLDAKVRIGKYGPYIEVENGDGVVTASIPKDLTPADLDPKQVEIILRQKTVGPDQLGRHPETGEPIYVKIGAYGPYVQLGDKSDENPKPKQASLPKGVTPENITLEKAIGLLSLPRTLGTHPGTGGKIQASLGRFGPYVVHDQGKEGKDYRSLKASDDVLTISLERALELISEPKKTRGSTSSKSKAALRELGTHPEDDAPINIYDGPYGPYIKHGKTNVGLPEGTSMEDVTLATALELLSAKTATAKTTRKTSKTSTTKSKSTAKSSNAATKKKGA
(1599) DNA topoisomerase 1 [Streptococcus mitis B6]
1
MATATKKKKSTAKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTIDGVFKKGTKQFQASFYGVDGKKLKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDYDKNKMLPDMAVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVDYFPDIVNVTFTAEMEGKLDDVEVGKEQWQRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCSSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPDCEFTSWDKPVGRDCPKCGHFLMEKKVRGGGKQVVCSKGDYEEEKIK
(1600) DNA topoisomerase 1 [Desulfovibrio aespoeensis Aspo-2]
1
MPKDLIIVESPAKVKTISKFLGKDYMVDASVGHVRDLPTRDLGVDEENGFTPRYEIIQGKEEVVKRLKAAAKKAGTVYLAPDPDREGEAIAWHVAELLRPVNSNIRRIQFNEITARAVKEALENAQDLNQNLFDSQQARRILDRLVGYKISPILWKNVKRGISAGRVQSVALKLLVEREKERRAFKTDEYWPFKVLLEGGNPPPFWLELHKLSGKAVKPGVNHISTQAEAEALQQTLEAGQFTVDSVQEKQRKRDPLPPYITSTLQQDANRRMGYSAKRTMSVAQRLYEGVELGRHGTTALITYMRTDSVRIAKEAQEAARELIIDRFGADYYPSKPRNFKTKGGAQDAHEAIRPVDVTITPDDVKSSLPSEQHKLYRLIWQRFVASQMAAASFWDTTVLVSAPATEWRAKGERLLFPGFLAAMDKSGTEAETELPKLVEGETLRLNELKKEQKFTQPPPRYSEASLVKTLEELGIGRPSTYAAIISTLLDREYARQEEKRFVPTELGFTVSDQLSEHFHALMDVGFTAQMESLLDDVAAGKQDWAKLLKDFGHDFYPTLEKARTEMARSQQETDIVCENCGKPMSIKFGKTGEFLGCTGFPTCRTIKNFTRDENGAIRIVERETPEETGVECEKCGKPMAIKQSRRGEFLGCTGYPDCKNIVNFQRDENGAISVIESEKLQVVGSCPDCGGELLLKKARTGSRFIACSNYPDCTYAAPFSTGVPCPVEGCAGELVEKSSRRGKIFFSCSAYPKCDYAVWNWPVNEPCPKCGHPILTRKTTKDKGEHLACPQKGCGYTREPDEPADTPDTPDLPDMPDDNA
(1601) DNA topoisomerase 1 [Krokinobacter sp. 4H-3-7-5]
1
MAKNLVIVESPAKAKTIEKFLGSDYKVESSFGHIADLPSKELGVDVDGDFTPKYKVSDDKKKVVKNLKSLAAKADMVWLASDEDREGEAIAWHLEQELGLTPDRTKRIVFHEITKTAILRAIDNPRQIDYDLVNAQQARRVLDRLVGYELSPVLWRKVKGGLSAGRVQSVSVRLIVEREREVLNFEPQASYRVDAEFTTEDGKSFRAKLPKNITTKKKAQEFLEKNLKATFKVDALTKKPAKKSPAPPFTTSTLQQEASRKLYFSVSKTMNMAQRLYEAGHITYMRTDSVNLSKDAKAGAQAEILAAYGKEFHKERNYKGKSKGAQEAHEAIRPTDFSKHSVNMDRDQMRLYELIWKRAIASQMSEAQLERTNVQIASSAGTDNFTANGEILKFEGFLKVYLEGHDDEDEEETGLLPDLKTGETLLNSYITATERFTRPPYRYTEASLVKKLEELGIGRPSTYAPTITTIQNRKYVEKGTVDGKERSYDVLSLENNEIKDRTLTEMVGSDKGKLVPTDVGMVVNDFLVQHFENILDYNFTAKVEADFDDIAEGKQEWTKMMKDFYTDFHPHVKDVEKNAEREVGERILGKDPESGKPVSVRLGKFGPMVQIGSVEDEEKPRFASLGPDQTLANLTYEQAMDLFKLPKVLGTFEEEEVSVNNGRFGPYVKFGATFVSLPKGRDPMDVDLDEAIVYIKEKQKADAPIYTYEDLPVQKGTGRFGPFIKWNGMFINVNKKYDFDNLSDDDIVELIEVKKQKEIDKVLQDFPEEGIRVEKARWGRSNIIKGKTKIELSKDIDAAALTLDEIKAYIEKKAPKKKAAAKKKAPAKKKAPAKKKAPVKKKTTAKKK
(1603) DNA topoisomerase 1 [Maribacter sp. HTCC2170]
1
MAKNLVIVESPAKAKTIEKFLGKDFKVESSFGHIADLPSKELGVDVDNDFKPKYIVDKDKKALVKKLKDLAKKAETIWLASDEDREGEAISWHLSETLGLEKEKTKRIVFNSITKSAIQKAIENPREINYNLVNAQQARRVLDRLVGYQLSPVLWKKIKPGLSAGRVQSVAVRLIVEREREIEAFTAQASFRISAEFKTENGGVFTAKLGKTFTTKEEAESFLNKNIGANFSIGSLDKKPAKKSPSAPFTTSTLQQEASRKLYFSVARTMQVAQRLYEAGLITYMRTDSVNLSGEAINAAKDAIVENYGEQYSTVRNFKGKSKGAQEAHEAIRPTDMTRQSPSLERDQSKLYELIWKRTIASQMSDAQLERTNVKIKASTHANEFTANGEVIKFDGFLKVYMEGIDDEDTSEEHEGMLPAMNIGDALHNNYITATERFSRPPYRFTEASLVKKLEELGIGRPSTYAPTISTIQNRGYIEKGSVEGSERKYIQFVLEAGSIKEKQLTETVGSDKGKMVPTDIGMIVNDFLVSHFSNILDYNFTAKVEEDFDEIAEGDEDWQKVMKAFYKDFHPTVLDVEENADRASGERVLGKDPKTGKQVSVRLGRFGPMVQIGTVDDEEKPQFASLAPDQSLNTITYEEAMDLFKLPRELGVFEGEEIQANVGRFGPYVKFGKKFVSLAKGESAMDVSLERAIELIKEKQKADAPIALYEGKDVIKGVGRFGPFIKWDGMFINVNKKYDFDNLTQANIEELIEAKKQKEIDKLIQEWPEEGIRIEKARWGRHNILKGRVKVELAKTVDATKISLEEAKKLIEKKSPKRKTKAKAKPKAKK
(1605) DNA topoisomerase 1 [Geobacter sulfurreducens PCA]
1
MSQHLVIVESPAKAKTIEKFLGPDYKVLASYGHVRALPSKQGSVDVEHDFEPRYAVLPESKRHIDAIKKELKASDSLLLATDPDREGEAISWHLLAALGVKPEKPPVPVRRVVFHEITKDAIVHAVENPRDISQDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFQSQEYWTIGAELAKEGGQKCTANLVEAEGKKLDKFDIPDQAAADRLVKALENATFTVDKVTKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMATAQKLYEGVAIDEGLVGLITYMRTDSVVLSNQALQEAHQVITSLYGPEYALAKPRFYKNKAKNAQEAHEAVRPTSIARTPAELKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGKGYRFRAAGTVIRFPGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLLKLLPEQHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLLERKYARLDSKRFIPEDVGMVVNDLLTNHFTTYVDYNFTATLEEELDQVSRGEKRWKPLLREFWEPFQGLLKQKEGEVSKADLTTEATDEACPECGKPLVVKLGKRGKFIACSGYKEGCTYTRNIDQGEGREQAEPVLSEEKCDKCGSPMLIKDGRFGKYLACSAYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPGPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
(1609) DNA topoisomerase 1 [Halothermothrix orenii H 168]
1
MGNKSNNTLVIVESPAKAKTISKFLGKGYKVEATMGHVIDLPKSKLGINIDKGFEPRYITIRGKGKVLKKLRKEVKKSKDVLLATDPDREGEAISWHLTRALKIDEDKPRIEFNEITKSAIKNALKNRRPIDKNLVNSQQARRLLDRLVGYKLSPLLWKKVRRGLSAGRVQTVAVKLLCNREKEIESFEPEEYWTISASFNKKDKDFIADLYRISGKKFKINNEKEAKQILEDLNKSKFVVSDIKEKTRKRNPNPPFTTSTLQQRASSILGFSAKKTMYLAQQLYEGIDMGSEGTTGLISYIRTDSTRISREAQKQALDYIKEAFGDKYIPDKVKVYKAKEGSQDAHEAIRPTSVDRTPGKVKKYLNKDQYRLYKLIWERFVASQMSPAQYKQVKVLIKAGDKYIFRAKGSRIIFPGFLRVNTSSQKKDIILPPVKKSERLDVKEIKPEQHFTQPPPRYTEATLVKTLEEEGIGRPSTYAPIISTIISRGYVERQGKQLKPTELGFIVTDLLSKYFPDVTDIEFTAHMEERLDKIEDGKDEWRNVLEDFYSNFSRRLKEASEEMEEVKLEDEVTDEVCEKCGRNMVIKYGRYGKFLACSGYPECKNTKPYVIKTGVKCPQCKEGELVQRKSRKGRTFYGCSSYPDCKFVVWNKPVKEKCPECGGLMVEKNSKKQGRYYLCINKECGYKKEV
(1612) DNA topoisomerase 1 [Arthrospira platensis NIES-39]
1
MSTLVIVESPTKARTIRNFLPKDYQVEASMGHIRDLPPSADEIPEEYKGKTWAGLGVNVEGNFEPIYVIPKDKQKVVKELKKALKQATELVLATDEDREGESISWHLLQVLKPKIPTRRMVFHEITSEAILQALQHCRDLDEQLVHAQETRRILDRLYGYTLSPLLWKKIARGLSAGRVQSVAVRLIVNRERERRAFRQGGYWDLKALLEQGKTEFEAKLITLNGVKVATGSDFDESTGQIAQGRNVVLLDSDQAQALKERLREKLWSVRNIDERSVTRKPAPPFTTSTLQQEANRKLRLSARQTMQVAQGLYERGYITYMRTDSVHLSEQAIVAARNCVEQKYGKEYLSPKPRQYTTKSKGAQEAHEAIRPAGNYFRTPQETELSGNDLKLYDLIWKRTVASQMADSRQTNISVDLQVEDAGFRATGKRIDFPGFLRAYVEGSDDPDAALENQELPLPPLKVGQHPDCKDLEAIGHETQPPARFTEASLVKTLESEGVGRPSTYASVIGTIIDRGYAQIKGNALIPTFTAFAVNSLLEKHFPDLVDIGFTARMENTLDEIATGQADQLPYLQKFYSGDGGLENQVKEQESQIDAKVARTIELENLGDATDGMTYRLCLGRFGPYIEAQKDEEIITASIPQDLTPADLTPELIQELIGQKTEGPEKLGVHPEAGEPIFMLIGPYGPYVQLGEESETNKKPKRVSLPKGLEKDAVTLDVAVSLLSLPRLLGLHPETGAKVKAAIGRFGPYVVHESKEAKDYRSIKAPDDVLTITFERALELLAQPKVGRRGTKKTLTPLRELGEHPEDGEPLNIYDGRYGPYIKHGKINASLPKDQAIETFTLEQALELLKAKAASGSKSKSKSKSTSSTTAKKSTTAKKSTTAKKSTTAKKSTTAKKSTTAKKSTTAKKSTTAKKSSTKGETE
(1615) DNA topoisomerase 1 [Lactobacillus rhamnosus ATCC 8530]
1
MADKKLVIVESPAKAKTIEKYLGRTYKVVASLGHIRDLPKSQMGVDVENNYEPKYISIRGKGDVIKSLKKDAKKASRVYLAADPDREGEAIAWHVSHILGLDPNAKNRVVFNEITKDAVKNAFKTPRGIDMDLVDAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKNFIPEEYWSLDAEFQKGRSKKFSASFYGIKNKKMALKNNEAVQKVLSQIDKAKPFSVTNVVKKERKRFPAPPFTTSTLQQEANRKLGFRTRKTMMLAQQLYEGINLGGKLGTVGLITYMRTDSTRVSNVAKTETSHYLHEKYGEAYAAVKIRQGKLQEGAQDAHEAIRPTSTLRTPESLASVLDKDQMKLYRLIWSRFVASEMTPAIIDTVAVTLNQNDVTFRANGSQMKFEGFTKLYVSSRDSGEKDNVLPPLAVGDAVKMLKTDPAQHFTQPPARYSEANLVKALEENGVGRPSTYAPTIETIQKRYYVKLNARRFEPTELGEIVNSLIVEFFPDIVNIKFTANVESELDSIETGEANWVKVIDQFYKPFEKEVAHAETGIEKIQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKAIVKEIGVICPKCHKGQVVERKSKRNRVFYGCSRYPDCDFVSWDKPVGRDCPVCGHFLVEKKSKAGTQVVCPNNDYKEALQKA
(1619) DNA topoisomerase 1 [Thiomicrospira crunogena XCL-2]
1
MTNLVIVESPAKAKTIEKYLGKGFTVRSSYGHIRDIQKKGMGIDIENGFMPNYEISPDKKKTVTELRKLTKEAETVWLATDEDREGEAIAWHLAEALKLDVNDTKRIVFHEITKTAIQKAIAEPRKVDMDLVEAQQARRILDRIVGFELSPILWKKIRTGLSAGRVQSVAVRLIVEREREIDAFESDYVYRLQGALDILDESQQVVGAVEVKRSAAFKTEEEAQAYLEQVKEAALTVSQLEEKPAKKSPKAPFTTSTLQQEASSKLGFSVKQTMMIAQRLYESGKITYMRTDSVNLSEEAIQKAHDEIVSEFGESYSTTRRYKTKNADAQEAHEAIRPTDFSVKSVTGERNEQRLYQLIWRRAIASQMADAQLKRTNVDIALEGMPAEKLVAKGEVITFDGFLKVYNLDDDAKEGQLPPLKVGQALKLGELLVRQSFSRPPARYNEASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVVKEDREGRQRDYRQLSLTVDGIDASTLTETTGTEKNKLFPTDIAGIVTDFLVKHFGDVLDYKFTALVESEFDTIAQGKESWQEMLTKFYQQFHPRVDAAEDVSREEAGQSRALGNDPKTGKPMFVKIGRFGPYVQLGDGENEEKPTFASLMPGQKMDTLKLEEALELFKLPREVGQMPESFSAKAVDGTEFAVEKGQIIIAKQGPFGPYLEYGPKMYAPIKGFDPLSIELEDAVALIESKIVTEAEKIIKVFPGTDVKILKGRWGPYITDVTTKKNAKIKKDEDALDLSLEECQKRLDEAPEPKKRGRVAAKKKAPAKKAAAKKTTAKKPAAKKPAAKKAPAKKTTRKTPAKKTSDKS
(1623) DNA topoisomerase 1 [Rhodopseudomonas palustris CGA009]
1
MNLVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDADFQMIWEVDPKAASRLNDIAKALKGADKLILATDPDREGEAISWHVLEVMKQKRALKDQQVERVVFNAITKQSVTDAMKHPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRETEIEKFVPREYWSLIATMATPRGETFEARLVGADGKKIQRLDIGTGAEAEDFKKAIEAANFRVATVEAKPARRNPYAPFTTSTLQQEASRKLGFAPAHTMRVAQRLYEGVDIGGETVGLITYMRTDGVQIDSSAITQARKVIAEDFGNAYVPDAPRQYTAKAKNAQEAHEAIRPTDLSRRPSDVSRNLDSDQARLYELIWIRTVASQMESAELERTTVDIEAKAGSRVLELRATGQVVKFDGFLAAYQEGRDDDSEDEDSRRLPAMSENEALKREALAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVRLEKKRLHGEDKGRVVVAFLESFFTRYVEYDFTAGLEEDLDRISNNEVSWKQVLSDFWRDFIGAVDEIKDLRVAQVLDVLDEMLGPHIYPAREDGGDPRQCPSCGTGKLNLKAGKFGAFVGCSNYPECRYTRPLASDSAGDADRVLGTDPDSGLEVAVKSGRFGPYIQLGEAKDYAEGEKPKRAGIPKGTSPSDVDLEMALKLLALPREVGKHPETGQPIKAGIGRFGPYVQHEKTYASLEAGDDVHTIGLNRAVTLIAEKVAKGPSKGRFGSDPGKALGDHPSLGAVAVKKGRYGAYVTAGGVNATIPNDKTEDTITLPEAIALLDERAAKGGGKAKKAPAKKAAAKKASADGEAKPVKKAAAKKAKPKAEGAAASKARAPVAAKTAAKKAAKPKDAAKSSAAKNG
(1624) DNA topoisomerase 1 [Agrobacterium sp. H13-3]
1
MLTDQFQRKNNMNVVVVESPAKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVLPDQDFEMSWEVDSASAKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLKKKRVLGDKPVKRVVFNAITKKAVLDAMANPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVSLRLVCDREAEIERFVSEEYWNISALLKTPRGDEFEAKLVSADGKKLQGRSIKTGDDANRLKALLEGATYIVDTVEAKPVKRNPGPPFTTSTLQQAASSRMGFSASRTMQVAQKLYEGIDIGGETVGLITYMRTDGVQMAPEAIDAARRAIGEQFGDRYVPEKARFYSTKAKNAQEAHEAIRPTDFNRTPDQVKRYLDADQLRLYDLIWKRGIASQMASAEIERTTVEILADKDGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDDEGRLPQINARENLAKQKINASQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLKTLSDREYIIIDKRKLIPHSRGRLVTAFLESFFAKYVEYDFTADLEEKLDRISAGELDWKQVLRDFWKDFFAQIEDTKELRVTNVLDALNEVLAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNFTRQLTSDGSEAEASVSNEPKALGADPMTGEELTLRSGRFGPYIQRGDGKEAKRSSLPKGWKPEEIDHEKALALINLPRDIGKHPETGKMISAGLGRYGPFLLHDGSYANLESIEDVFSIGLNRAVTVIAEKQSKGPGRGRNGTPAALKELGDHPDGGPITVRDGRYGAYVNWGKVNATIPKGQDPTSVTLDESLVLIAERIAKTGTGGKPAKAKKPAAKKADGDTAAKPKATKAKAATKSKTAAKPKAAAKPKKAES
(1629) DNA topoisomerase 1 [Borrelia afzelii PKo]
1
MQKKKLIIVESPTKAKTIKKFLDNSFLVEACIGHIVDLPNNAKEIPKEYKKYEWANISIDYNNGFDPIYIIPSNKKPIVSKLKKLVKTINEIYLATDQDREGETIAFHLKEVLKIKNYKRMIFHEITETAITESLKNTRNIDMNLVNAGEARRLLDRLYGYTISPLLWKKIAYGLSAGRVQSVGLKLLIEKERTRINFKKANYYSILLQCKHEKKDLLLETKLEEIDGKNIAEGKDFTNETGKLKNSAKSIIITQDLMIELEKELENGQKIELISIETKKINIPPPKPFTTSTLQQEINKRLKIGTKQIMQHAQKLYEHGYITYMRTDSHNIAKIAKDKITKIIKNIYGKDYIEKKDRIYKKEKMTQNAHEAIRPSEMFIPNENIEIESKTAKEIYKIIWDRTIISGMKDAIKENIKLTFKYKNLIFKSNFTKIIFDGFLKHTKEKDEHLNINFDLIKKGDIFSIVKMQTSEHETKPPFRYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNTLIPTIKGAAVINLLEKYFPVLIELNFTSNMEEKLDKIAIGKLDKIKYLSKFYNGKKGLKDTVMQLEPKINSSEFRTVIESQNLENKDNSINYTINIGKYGPYLIFKGHNYSIITTTPLENLYKKDEIEKIINEKELKPNILGIDPLTGLNVIFKNTIYGSIVQLGEDTYAPQEYTKKGKPKKLKIIKAKKASAKKIDPENMTLELALKLLSLPKLIGKHPQTNEQIIAATGVFGDYIKTESGSIACSLKKDEKAYDITLDKAISLLNERVNKVGIIVKMIAFSKNKIGNKIYIYKKNDRFYAKIKRKKIDLPDNINLDEINEKYVFNLL
(1630) DNA topoisomerase 1 [Croceibacter atlanticus HTCC2559]
1
MAKNLVIVESPAKAKTIEKYLGKDYKVESSYGHIADLPSKELGVDVEGDFSPKYVVSKDKKDVVRKLKKLAKDAETVWLASDEDREGEAIAWHLFEELDLKSESTKRIVFSEITKTAIERAIKNPRGINYNLVNAQQARRILDRLVGYEISPILWRKVKGGLSAGRVQSVSVRLIVEREREILDFSPVGSYRVDAEFKTEDGASFKAKLPKNFDTKEDAEAFLKDNLNADFKVGDLTKKPAKKSPAPPFTTSTLQQEASRKLYYSVSKTMTMAQRLYEAGMITYMRTDSVNLSDQAKKGAEKEIKKAYGDNFHKSRNYKGKSKGAQEAHEAIRPTDFSKHTISGDSDQVRLYELIWKRAIASQMSDAQLERTNVKVEANTHDKQFTANGEMIKFEGFLKVYLEGSDDEDQEQSGLLPNMKVNDTLVNSYITATERFTRPPARYTEAALVKKLEELGIGRPSTYAPTITTIQNRKYIEKGTVDGVERDYAKLQLKNNKVSEKTMTETVGSDKGKLVPTDVGMVVNDFLVQHFSSILDYNFTAKVEEDFDDIADGNEKWKDMMKDFYKDFHPKVKDVAENAEREVGERILGKDPKTGKPVSVRLGKFGPMVQIGSVEDEEKPLFASLGPNQSLQSITYEEAMDLFQLPKEIGEYNGEKVEVNNGRFGPYVRYGKTFVSLDKGEDPLDVSMDRALELIKAKEKADAPIYHYEDLPVQKGVGRFGPYIKWNGMFINVNKKYDFDNLTNDDIVELIEIKKQKEIDKVVHNWEDEGIRVEKARWGRHNIIQGKIKVEIPKTVDAQKLTLEKAQEYIEKKKPKKKATKKKTTAKKKTATKKKTTTKKK
(1633) DNA topoisomerase 1 [Treponema azotonutricium ZAS-9]
1
MKKEKKPKKEKKYLEKKTLVIVESPAKAKTIEKYLGPSYIVKASMGHLIDLPKSRLAIDVEKNFEPEYITVRGRAKLLKELQGDAKKAETVLLASDNDREGEAIAWHLRNAITAKTDKVPIQRISFNEITPQAIKDAVAHPAAIDEFKVNAQKARRVLDRLVGYNLSPLLWKKVKNGLSAGRVQSVALRLICEREKEVESFIPEEYWTLEADFKVGKSSYTAQLVSWKDAKPELKSEAEVNAIIDIIKNGECVVSDVRETDKSVKPKPPFTTSQLQQTAANRLGFTSKKTMQIAQQLYEGVNMGSSRIGLITYMRTDSVRISQTALDEVREWIGKNFPKELPEKIVEYAVGKKAQDAHEAIRPTYVSYAPDDVKEHLTRDQLRLYSIIWERFVSSQMNNAKTRTVSADIKAGDGIFRIAGTKIIEKGFYQVMKVLSSRDEKGSSYPALKKGDKVKVDDFRPEQHFTQGPARFTDASIVKTLEEKGIGRPSTYAPIISVLLDRYYVVRSNKQLVPTVLGRLINDMLVDNFPNVVDAGFTASMETKLDEVEENTINWPDMIRDFWDPFIDRVDEVGKNLESQKGSLDEPTDKVCEKCGKPMMKKLGRFGYFLACSGFPECRNTKSIPLAKCPKCGGDVVARKTKGRGKEFYGCTNYPDCDFISHFKPLNQVCPKCGQFMVEKYDKKNGNHKACINPECDYLHSSEEEEEK
(1635) DNA topoisomerase 1 [Sulfurihydrogenibium sp. YO3AOP1]
1
MSEKKIVIVESPKKAKEISHFLGKDFIVKATVGHFKDLPENEMGVDLNTYEPKFVIKSQNHKKILSEIKKLAEKSEVIIATDPDREGYAIGFFMYEELKKKAKEVKRAEFHEITKEHIKEKIKNAVPFEKTNFGLFNAFLGRRVGDRIVGYTLSPIASREIGGRFSVGRVQSPAVRLIVEREIEIQNFKPTPYYVLSAVLRATSHVSPLTFTAIYENPKIENKEEAEKIYADIKDEKIATIKKVEKKQVKQSPKPPFTTSTLQQTASTVYRFAPEKTMMLAQDLFESGLITYHRTDSVRISEKAIDGIRNLINKEFGKDYLPEKIRVYKSKNTQADAHEAIRITHFVNLEEQKKLIKEKGLSEDHFKLLKLIYERTVASQMADAIFERTSAAVDIKGYTFKASGSILKFKGYKAVYDLEEEEDKEENQKLPDLKNKDVLTLEKINLEEKFTKPPARYTEGGLVKKLEELGIGRPSTYATIIKTIKERGYVVKENGSLRPTENAFHLIEYLNTRYNWVIDYSFTKKMEDFLDKVEENKKDWKEFVKQLHEKSGSKQNVKISKKMLDYAKDLAEKHGKSIEEIKDDPEKLKEFIDAHAEKNPSQKQIEYAKSLAEKTGLKLTEKELLDRKLLTKWINKAKKEMMKNYQLSEKQKNVLIKYGREDLVNNPVQALKFIKSKLSRYKK
(1637) DNA topoisomerase 1 [Bacillus coagulans 36D1]
1
MDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIDRENEIKSFVPEEYWTIAGSFKKGKDTFQASFYGVDGKKIQLKSEADVKKITGMLKSDKFQVSSVTHKEKKRNPAPPFTTSSLQQEAARKLNFRAKKTMMVAQQLYEGIDLGKEGTVGLITYMRTDSTRISEVAKTEANQYIREKFGENYLRQEERKEKKQANAQDAHEGIRPTSIFRDPGSVKSFLSRDQYKLYKLIWERFMASQMAPAILDTMSATLANGTVLFRASGSKIQFPGFMKVYVEGSDDQQEEGERYLPHLEEGDVVQSESIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALENKRFVPTELGEIVLELIREFFPEIIDVEFTADMEKDLDEIEEGKVPWVQIIDAFYQNFEARLKKAETEMEKIEIKDEETGEMCELCGSPMVYKMGRYGKFMACSNFPDCRNTKPIVKKIGVTCPKCGKGEIIERKTKKNRIFYGCDRYPECDFVSWDKPVGRKCPKCGDMLVEKKLKKGTQIQCVHCDYKEQSVK
(1638) DNA topoisomerase 1 [Thermoanaerobacter mathranii subsp. mathranii str. A3]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFTPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNFTKFEAKFYGTKEDKVELKTKEDVDKVLAALSEEYTVDKIKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYANPGANYASKKANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDIQEEEEKTVPVLQEGTKLLLKELKPTQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDNKNLKPTELGFIVTDALKEFFTKIVDVKFTAEMEEQLDKIEEGQAKWYEVVQEFYNDFYKTLKIAEEQMEEIDIKEEVEVTDIKCEICGRPMVIKKGRYGKFLACSGFPECKNTKPLYEKIGVKCPKCGGEIVRKKSKKGRMYYACENAPNCDFILWDKPVEEKCPVCGSLLIEKNTKNIHILKCSNAECDYQKEVK
(1643) DNA topoisomerase 1 [Rickettsia rickettsii str. 'Sheila Smith']
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDATKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTQVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKAVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCHTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIIIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(1649) DNA topoisomerase 1 ['Nostoc azollae' 0708]
1
MSTLVIVESPTKARTIRNYLPQDYRVEASMGHVRDLPQSASEIPAAVKGEKWAQLGVNIEADFEAVYVVPKDKKKIVTQLKDALKGVDELILATDEDREGESISWHLYQLLKPKIPTKRMVFHEITQEAIKKALQNCRIIDEQLVRAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVTKERQRRAFHEGTYWDLKASLLQEKTPFRAQLVTLGGTKVATGSDFDPATGQITAGHNVVLLNKEQAVELQEQLTGKTWNVNNIEERPVTRKPAPPFTTSTLQQESNRKLCLSARDTMRVAQNLYEQGYITYMRTDSVHLSDQAIAAARSCVEKKYGKQYLSPQPRQYTTKSKGAQEAHEAIRPAGSTFRTPQETGLGGREFAVYDLIWKRTVASQMPDSRQTQITVQLQVEEASFRSSGKRIDFPGYLRAYVEGSDDPEAALEDQEVILPPLKVGDHPTCTELEAVDHETQPPARYTEASLVKTLESEGIGRPSTYASIIGTIIDKGYAHLVSNALIPTFTAFAVTDLLEKHFPDIVDPSFTSKMEQTLDDIATGEAKWLPYLKKFYLGEKGLETLVRERESQIDATTARTVELENLDAKVRIGKYGPYIEVENGEGVVTASIPKDLTPADLDPKQVEVLLRQKTTGPDQVGRHPETGEPIYVKIGTYGPYVQLGDKTDENPKAKQVSLPKGVTAENLTLDMAVGLLALPRTLGVHPATNSRIQASLGRFGPYVVHDQGKEGKDYRSLKAVDNVLTISLERALELLAEPKKGRASSTSKSKAALRELGTHPEDDSPINIYDGPYGPYIKHGKTNVSLPEGQTVETVTLSAALELLQAKASTKSTTRKTTKSTSSKTKSTTKSSMSRAKKKEASN
(1650) DNA topoisomerase 1 [Spirosoma linguale DSM 74]
1
MSKNLVIVESPAKAKTIEGYLGKDFTVKSSFGHVRDLPKDGLAVDVTNGFRPSYEISPDKKKLVSELKSLAKSAEEVWLATDDDREGEAISWHLKEALGLRDNTKRIVFREITKNAILNAIKSPRTIDVDLVNAQQARRVLDRLVGYELSPVLWRKIKGGSTGLSAGRVQSVALRLVVEREREIDKHSAKSSFKVTAQFIVDGNKVLNAELPKNFATAAEARAFLEACVGATFTIKNLETRPAKKSPAPPFTTSTLQQESSRKLSYSVDRTMRIAQNLYEAGKISYMRTDSTNLSQEAIDKAVAEIGTEFGEKYIQTRQFKTKNESAQEAHEAIRPTNFNDRSAGGDRDQKRLYELIWKRAIASQMADAQLERTTVTIGIRFANGATTTFQTNVDDSPFVETPEAIAPNRSFPNELVAQGEVIKFDGFLRVYLESKDDEDDEDAKGMLPPLNIGQGLNLGQMKATEKFTRPQPRYAEASLVKKLEEMGIGRPSTYAPTISTIVNRGYVTKQDKPGQERKYTEYTLQQNQISETSGKETYGSEKAKLFPTNTGIVVNDFLVEYFPDIVDYKFTATVEKEFDEIADGRMNWQTMLQDFYGDFHKNIEDIQGSSVVAFKTGARDLGIDPRSGKKISARLGKYGAYAQIGESTDDEKPQYANLRDGQLIETITLQEALDLFSLPREVGFFEDKPMTIGIGKFGPYVKHDDKYVSLTKEDDPYTIDESRAIQLIQQKRAEAVSEALGEFEGKMVSTGKGRFGPYVKFEDKYVSLPRNESLAGLTLERAIELIQAKRVVEANKYIKEFPENPAVKVINGQYGPYLAIGKRNVKIPKDVDPASLTLEDCLKLGGDEPAAKAPAKKAAATKATATKAAAKPKATATATKKPAATAKKAVTKK
(1655) DNA topoisomerase 1 [Borrelia turicatae 91E135]
1
MQQRKLIIVESPTKAITIKKYLDNSFLVEACIGHIRDLPNSAKEIPEEYKKFEWATLSIDHQNDFKPLYIIPNNKKTVIEKLKNLIKEKDEIYLATDQDREGETIAFHLKEVLQIKNYKRMVFHEITKSAIIDSLNNTREINMNLVNAGETRRILDRLYGYTISPLLWKKIAYGLSAGRVQSVGLQLIIEKEMTRINFKKANYYSITLECKHNKNDIQIKTILEKIKNKNVAESKDFVNDTGALHDPDKTIVIDKTLMNMLTKKLNNTKEIEVISIETKEIKQAPPKPFITSSLQQEVNRRLKIGTKQIMNYAQKLYENGYITYIRTDSYHIAKTAREKIKTIIKQKYGEEYIETNDRLYAKAKMAQDAHEAIRPSELFTSPEQIQIESETAREIYKIIWDRTIESVMKDARKKIIKITLKYENLTFKTSFTTIIFDGFLKNSKEPYENSIIDFSLIKEGDKFVILDVNPEEHETKPPLRYTEASLVQKLEKEGIGRPSTYSTIISTLFEREYIFKHNNTLIPTIKGAAVINLLKKYFPVLIELKFTSHMEENLDKIAIGTLDKIKYLNKFYNGEEGLKNTINKIEPIISPEEFRIVYEYTNNEKFSYKVNLGKFGPYLIFNGNNYAINVTTPLENLYKEDEIKKIISEKEIQPNILGIDPETGLNVIYKNSKYGGIVQLGEDIYAPQEFTKTGKPKKPKIIKAKKMSTKNIEHENITLELALKLLSLPKIIGEYPKTHEKIIATTGVFGDYIKTENNSIICPLKKDIKAYEITLEESIKLLDAKLEKNGIIVKIIPLAKNKVGNKIYVYKQNDRFYAKIKRKKVDLPTDIDLNQIDATYIFGLM
(1657) DNA topoisomerase 1 [Pediococcus claussenii ATCC BAA-344]
1
MPTAKKNLVIVESPSKAKTIEKYLGRSYKVIASLGHIRDLPKSKMGVDIDNNYDPHYISIRGKGDTIKKLRTEAKKAKKVYLASDPDREGEAIAWHLSYLLGLDPKDKNRVVFNEITKDAVKNAFKTPRSIDTSLVDAQQARRILDRLVGYSISPLLWQKVKKGLSAGRVQSIALSLIIKREQEIRDFKPEEYWSIDSEFKKGRSKFNASFYGTGGKKKALKNEKAVQKILKLINPKDDFDVTSVKRKERKRFPSPAFTTSSLQQEANKTLNFRTRKTMMAAQQLYEGINIGKEGTVGLITYMRTDSTRISDIAKHEASVLIHEKYGAEYAAIKPRKGKMPEGAQDAHEAIRPSSVNRTPEDLKEYLSKDQYRLYNLIWSRFMASQMTPEVSDTMAVTIEQNDVQYRANGSKTKFEGFTKVYKTNKEKDNSLPAMEEGDKVKLVSNNPNQHFTQPPARYSEANLVKALEENGVGRPSTYAPTLDTIQKRYYVKLESRRFEPTELGEIVNDIIYEFFPDIVNIDFTAHLETELDEIEEGKEDWVKVVDGYYKPFSKEVDTAQEQIEKVQIKDELAGFDCEVCGSPMVVKMGKYGKFFACSRFPDCRNTQAIVKEIGVTCPKCGIGQIIERKSKRGRLFYGCSRYPDCDFVSWDKPVGRKCPVCHSFLVEKKIKGGKQVVCPNGDYEETPQK
(1659) DNA topoisomerase 1 [Desulfotomaculum reducens MI-1]
1
MSKTLVIVESPAKAKSIGKYLGKNYTVKASMGHVRDLPKSQFGVDVENAFSPKYITIRGKGDILKELRSAVKKVDHVLLASDPDREGEAIAWHLTKLLEIDEETPCRIEFNEITKNAIQAAVKQPRRIDVDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEIQAFIPEEYWTLTGKFLKSAKSPFEAKLHKHKNKKIVIPNQETMDKILAELKGAAYVVSNVTRKERLRNPAPPFTTSSLQQEASRKLNFTSRKTMVVAQQLYEGIDLGKEGPVGLVTYIRTDSTRVSETAIEETRSFIMERFGPAYVPKQPRQVVAKGKVQDAHEAIRPTSVNRDPDSIKQYLTNDQFKLYKLIWSRFLASQMASAVIDTTSMDISAGDYLFRATGSIIKFPGFMQVYIEGNDDGHKEEESVLPELAKGDKVQAKDLTPKQHFTQPPPRYTDATLVKVLEEKGIGRPSTYAPIVETIQRRGYVVRENKQFYPTELGVIVVDLLKNHFPEIINVEFTADMEKKLDQIAEGEQQWAGVLRDFYEPFSQTLETAEEAIGKVQVADEVSEEICEQCGRNMVIKLGRYGKFLACPGFPDCRNTKPLLEPTGVGCPKCEGEMVLRRSKKGRKFYGCSRYPECEFVTWDMPTKEKCTQCGEMMVEKKSRGKEKVLQCVNEHCPSKGEKAASNINGNKKKTVKNNKK
(1661) DNA topoisomerase 1 [Planctomyces brasiliensis DSM 5305]
1
MVAKNDKYKALVIVESPLKAKKIGEFLGKDYVVRASLGHVRDLPSKASEIPAAVKKESWSTLGVNTSEKFEPLYVVPPDKKKLIKELKDLLKDSSELIIATDEDREGESIGWHLVQLLKPKVTVRRMVFSEITKTAIQEAIRNTREINEELVEAQETRRVLDRLYGYTLSPLLWKKIARGLSAGRVQSVAVRLLVRRELERIAFRSGTYWDLKAELKATEGNPFEAVLSTLGGKRLASGKDFDETTGRLKDGSDVLLLGQDEAERLQAQLLESPWKVSDIEERMSNRKPPAPFITSTLQQEANRKLGMSARQTMQTAQRLYENGHITYMRTDSVTLSNEAVQAARGRIEDLYGGDYLSPSPRQYASKSKNAQEAHEAIRPSGTEMKTPEELNLSGPEFKLYSLIWKRTMASQMAEARLKFLNVTIAVGEAEFKATGRQVVFPGFFRAYVEGSDDPEAALDDRDAMLPPLSQEESLDCKQLDPVAHETKPPARYTEASLVRMLESEGIGRPSTYASILSTIQDRGYVRKDGNQLTPTFTAMAVTRLLEDNFPNLVDTQFTAGMEQTLDDISNGQAERLPYLDRFYSGSDGLETQVKSREEQIDPRKACTLELSGLQSNVRVGRYGPYLEKDNDGEPMTASLPQEISPADVNNEMAEKLFELKAKGPESIGMHPEEGLPIFVLSGPFGPYLQLGEQQEDGPKPKRVSIPKNYDPTKVDLDLAVKLMELPRTVGQHPEDGKVVKAGIGRFGPYVQHDGKYKSLGKDNDVLTVGLEEAVELLKQARTKQAPKPLREIGKHPEDESVIAVFEGRYGPYIKFGKLNVTVPKDTDIHSITVEEAVQWIDEKAAKKGVKKKSAKKKAAKKSTKKKAAKKKATKKKAAE
(1663) DNA topoisomerase 1 [Brucella canis HSK A52141]
1
MGREFRLLYMNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYTIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRITNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRNIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1664) DNA topoisomerase 1 [Brevibacillus brevis NBRC 100599]
1
MADTLVIVESPTKAKTIGKYLGSKYIVKASIGHVRDLPKSQMGVDVTHNFEPKYITIRGKGDVLKGLKDAAKKVKKVYLAADPDREGEAIAWHLAQYLGLDMNQPLRVVFNEITKDAIKEAFKHPRHINMDLVNAQQARRILDRLVGYNISPILWKKVRKGLSAGRVQSVAVKLIMDREREIQEFIPEEYWTIASTLISDGKEINAKFYGYGDEKVELHSEDDVAAVLKRMKNKPYVVQKVTKRERKRNPAPPFITSSLQQEAARKLNFRTSKTMRIAQELYEGIDVGNKEGAVGLITYMRTDSTRLSVTAQNEAKEYILEKYGPDYVLSEPRNQAKNENAQDAHEAIRPTGVMRTPDEIKEYLSRDQLRLYRLIWERFLASQMSSAVLDTMSVDIDAGGVTFRATGSKVKFPGFMKVYIEGNDDGTEEESFLPPIEEGQILDQKEIEPSQHFTQPPPRFSEARMLKSMEEMGIGRPSTYAPTLETIQKRGYVALEEKRFVPTELGEIVITLVEEFFPEILNVEFTAHMESGLDNIEAGNTNWVQVLDDFYQDFAKRVVVAEEEMKEVELKVEESDETCELCGSVMVYKLGRFGKFLACSGFPDCRNTKPIVKEIGVKCPQCETGEIIERKSKKSRIFYGCNQYPECDFVSWDKPIARPCPKCSSMLVEKKRKKQGVSIICTKCDYQEEADS
(1668) DNA topoisomerase 1 [Helicobacter bizzozeronii CIII-1]
1
MKANPKKLIIVESPTKAKTIANFLDQNYQVIASKGHVRDLSKYAMGIRIQEDKFIPKYIVDKDHEDIVEQILSLAKSASQIYIATDEDREGEAIGYHIAYLIKENQRTSQTKKMSANQILQETLDLEQQTNHAPSSNPIFHFPRIVFHEITKSAILHALKHPKTLDVYKINAQLARRLLDRIVGFSLSSLLASKIAKGMSAGRVQSAALKIVVDREREIQAFKPLIYYNIEGIFEGCIEASLESYLGEKIKKQSLTDAPDALKMVAHLRAQTYQVQEITHKNKTSPSPPPFMTSTLQQSASTHLGYGPSKTMGIAQRLYEGVATPEGMSGVITYMRTDSLNVAKEAIKAARDFISTTYGAPYLPNKPKTYTAKNKAAQEAHEAIRPTNLNFTPTIAKDYLKPEEYRLYTLIYNRFLASQMTDALFENQTLRLSCADGTFKASGRKLIFDGYHRVLGECDRDKLLPALQKDQSVRLDKLEAKKCSTEPPTRYSEASLIKTLESLGIGRPSTYAPTIALLANRSYVKLENKQLVPTEDAFVVIGILEKHFSEIVDAAFSAGLEDKLDAIASSKASWQQVLFDFYTPFMDKIEAGKAQIASQKSSVPTGEFCPECGLELVQRKGRFGEFVACSGYPKCKFVKPPSEQTPTPLEPCEKCGKPMVLKKGRFGEFVACSGYPQCKNIRSKAPQLKEEKVAGVCPECGGHVVEKRGRRGLFYGCANYPQCQFISNYPPSDQKCPECGYVLVFKAYKRKPSVWACLKCAFTRLADV
(1669) DNA topoisomerase 1 [Pediococcus pentosaceus ATCC 25745]
1
MPAAKKNLVIVESPSKAKTIEKYLGRTYKVVASLGHIRDLPKSKMGVDLENDYEPHYISIRGKGDTIKNLRKEAKKAKKVYLASDPDREGEAIAWHLSYLLGLDPKDQNRVVFNEITKDAVKNAFKTPRSIDMTLVDAQQARRILDRLVGYSISPLLWQKVKKGLSAGRVQSIALSLIIKREQEIKAFEPEEYWSIDSEFKKGRSKFKAAFYGVNNKKMKLPNNDKVQEVLKKIDPKADFDITEVKRRERKRYPAPAFTTSSMQQEANKTLNFRTRKTMMAAQQLYEGINIGKEGTVGLITYMRTDSTRISEVAKHETSLFIHDEFGAEYAATKPRKGKMPEGAQDAHEAIRPSSVLRTPESIKEYLNKDQFRLYNLIWSRFVASQMTPEVSDTMTVKIEQNGVQFRANGSKTKFEGFTKVYKTNKDKDNVLPNLEEGDQVQLVTNNPNQHFTQPPARYSEATLIKALEENGVGRPSTYAPTLDTIQRRYYVKLESKHFEPTELGEIVNEIIYDFFPDIVNIDFTAGLEKDLDSIEEDKEDWVKVVDRYYKPFAKELAKAQEQIEKVQIKDELAGFNCEICGSPMVVKMGRYGKFFACSRFPDCRNTQAIVKEIGVTCPKCHQGQIIERKSKRGRLFYGCSRYPDCDFVSWDKPIARECPVCHSYLIEKKIKGGKQIVCPNGDYEETPQK
(1672) DNA topoisomerase 1 [Caulobacter sp. K31]
1
MIVVVVESPAKAKTINKYLGSGYTVLASYGHIRDLPSKDGSVEPDNDFAMHWEADAKGAKRIGDIVDAMKGADGVILATDPDREGEAISWHVLEVLQKKKAIKDKSVQRVTFNAITKTSVLEAMAHPRDIDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVCLRLIVDRELEIERFKTQEYWSVEADVTAGAEPFVARLVKHENKKLTKFDLNNESSALAAKAAVEKAVFKVAAVEKKPGKRSPAPPFTTSTLQQEASRKLGFSAQRTMQAAQKLYEGIDIGGETVGLITYMRTDGVSVEPEGIAEARSVIGSVYGETYVPETPRYYKAKAKNAQEAHEAIRPTSLKRNPGSLRLESDLGRLYELIWKRMIASQMESARIERTTVDLESADGQTGMRATGQVVLFPGYLAVYEEGRDDEGDEDSARLPMIEEGAAAKVLDARADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASVLTVLRDREYVRMDKQRFIPEDKGRLVTAFLEQFFRRYVEYDFTAALEEQLDLVSDGKLDWKQFLRDFWKDFHAAVGEIAELRTTNVLDALNESLGPHIFPDKGDGSDPRLCPTCGTGQLSLKVGKFGAFIGCSNYPECRFTRQLATAEGEGEAEAADKELGINPATGRAVWLKNGRFGPYVEEPAAEGSGDKPKRSSLPKGWTPAGLDLEKALRLLALPREVGMHPDDGKKITAGLGRFGPFVLHEGTYANLENPEEVFDIGLNRAVALLADKRAGGGRPQRGQAAALADLGVHPEDGKPVKVLSGRFGPYIKHGDTNANVPKGADPAALTLAEAVVLLADRVAKGGGKKPAKKAAAKKAPAKAKAAAATDGGAPAKKAPAKKAPAKATGAKKTAAKKPAAKKAKAEA
(1674) DNA topoisomerase 1 [Dehalococcoides mccartyi 195]
1
MKEKLVIVESPAKARTISKMLGKDFNIMATMGHIRDLPKSTLGVDVENSFTPKYVSLKAKAKVIKELKDAVKNSKAIYLATDPDREGEAIAWHISEVTKANLAKPKRVVFHEITKEAIDKAFKNTRELDMDLVNAQQARRVLDRLVGYKLSPLLWRKVQRGLSAGRVQSVSLKIIVDREREIEKFVSAEYWNIEALLNKKVKSAAFKASLAGYVTKGKLEIHNESEAEQIKKELEVSDYQVLKIKKKSNLRQSPAPFITSTLQQEAWRKLHFSAKQTMVIAQQLYEGLNIEGEGEVGLITYMRTDSTNVARTAVAETRDYISEKYGPAYLPKQARVFSSKVKGAQEAHEAIRPTRIIRTPDLIKKSLSTEQFKLYQLIWQRMMASQMSPAVFDNTTIDIEAKHQPSKTRYLLRTTSSVNTFPGFTIVYIEGKDEDEEAAQSSLPPMEEGEELKLKSLEASQHFTQPPPRYTEATLIKALEQYGIGRPSTYAPTISTIQEREYITKLKGSLKPSELGMLVNDLLVEYFPDIIGIDFTAAMETELDKIATEKLDWVPIIRRFYEPFIKEIEAASEKIEKIKPPEEELDELCPECNAKLVVKRGRFGKFIACSRYTKEEGGCRYTRSYQIKTGAKCPECNSDIVEKYSKKGKIFYGCAGYPNCKFVSFYKPLSKPCPECGALMIKSGKNWAKCTKCGKRKKLEDES
(1684) DNA topoisomerase 1 [Sulfurospirillum deleyianum DSM 6946]
1
MEKSLKNLIIVESPTKAKTIKNFLGKNYTVVASKGHIRDLPKSSFGIKIDNQTFIPEYRVPKDHASVVKEIKELAKEADQVYIATDEDREGEAIGFHIATAIGKDPKSLPRIVFHEITKNAITHALENPRILDESSINAQQARRLLDRIVGYKLSPLLSSKIQKGLSAGRVQSSTLKIVVDREKEIRAFKEEEFWSIDALFNKTIEASLVEFEGEKIEKMSIGNQERAYAIKEKLLKEAFHVALLEKKERESSPSPAFMTSTLQQSASSALGYSPKKTMMLAQTLYEGVKTHQGVQGVITYMRTDSLNVSKEAIEAAREQILSQYGKTYLPEKARFYANKSKGAQEAHEAIRPTILEFTPAIASAYLAPDELKLYALIYNRFLASQMNNARFESQTLIFESQSGKFKASGRKLLFDGFYKVYGDNDKDKLLPDLALKQEVTLSKLDANQHFTEPPSRYSEASLIKKLESLGIGRPSTYAPTISVLSARDYINIEKKQIVPTEVAFQVTELLEQHFPQIVDSSFTSTMEERLDLIAEDKEDWQAILWNFYEPFDAQVAKGKTEIQSQKVIVFTGEMCPECGKELVRRKGRFGEFIACSTYPTCKYTQNLKKVSESAPKEKVTLSVPCPECGGEIIERSSRRGKFFGCGNYPKCKFISNYEPTDKKCPECGYIMAKRELRKKEIYECIKCKHKEEA
(1686) DNA topoisomerase 1 [Lactobacillus salivarius UCC118]
1
MPTTQKPKKKTTKRTRKKNLVIVESPSKAKTIEKYLGSNYKVMASLGHIRDLPKSKMGIDVENGYEPHYISIRGKGDVIKELRKEAKKASHVYLAADPDREGEAIAWHLSYLLGLNPEDKNRVVFNEITKDAVKNAFKSPRSIDMNLVDAQQARRVLDRLVGYSISPLLWSKIKKGLSAGRVQSIALNLIIQREKEIRDFKPEEYWTIDAKFKKGRTKFEADFWGVDNKKKKLSNEKDVKEVIEKIDKDKPFNVINIEQKERKRMPPLPFTTSAMQQTANNNLKFRTQKTMMVAQQLYEGINIGRGGAVGLITYMRTDSTRISSVAKHEAAVFLHENYGEEYAASKPRQGKLSENAQDAHEAIRPSSVERTPEKMAKYLDKDQLKLYTLIWSRFVASQMTPAVFDTMRVDIEQNGVQYRANGSKMKFPGFIKVYKAATSKDNLLPELKVGDEVDMVQNQPNQHFTLPPARYSEATLIRTLEENGVGRPSTYAPTLSTIQKRYYVKLVSRKFEPTELGEIVNSMIEECFPDILNVDFTAHLEDQLDDVEEGKEEWVRIIDEFYQPFSKEVDNAQVKMDKIKIKDEPAGIDCEICGAPMVIKLGRYGKFYACSRFPDCRNTKAIVKEIGVVCPKCHKGQIIERKSKKNRVFYGCSLYPDCDFVSWDKPIGRDCPKCSHYLVEKKTKKGMQVKCSNCDYEEAIQNN
(1688) DNA topoisomerase 1 [Thermoanaerobacter pseudethanolicus ATCC 33223]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKGYANPEANYVSKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVEEFYKDFYKTLKIAEEQMEEIEVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPDCDFILWDKPVEEKCPVCGSMLIEKNTKNVHILKCSNPGCDYQKEVK
(1689) DNA topoisomerase 1 [Veillonella parvula DSM 2008]
1
MSIKRSIVIGEPKAASTSKDTKKKNTKKESTTIKRKVAKESLTPMGIVRDKSVLQTSVPPEQREPRVYNPDGKVLVIVESPAKSKTIEKFLGPNYVVKASMGHLRDLPKSQIGIDIEHDFTPRYSNLVTRKKVIDELVSYADESSAVLLATDPDREGEAISWHLAYILNVDPTSTCRITFNEITKNAVAEALDSPRTIDMNMVDAQQARRVLDRIVGYKLSPLLWKKVCKGLSAGRVQSVAVRLICEREREIQAFVPQEYWTIEGNFETPKKEAFIAELTHIKGEKIDITTESDAQAIVDAIGNEDAVVTNIEKRKRSRKAVPPFTTSTLQQDGVRKLNFGAKRTMMIAQHLYEGLEIGSYGHVGLITYMRTDSTRISKEMQAMAKDFILRNYGEDYYPSKPNVYGSKGSAQDAHEAIRPTSLELTPKMVEPFLSRDELKLYTLIWNRFMASQMAPQQNESTTIELNVKNDYTFKATGSRVIFPGFSAVYEDAKKEDVPQLPALKKNYAAHTVEVLPEQHFTQPPPRYSEASLIKTLEELGIGRPSTYAPILDTIVSRNYVENTNKQFVPTELGFVVVDFLITYFEKIINTGFTRDLEEELDAIASGKDTYVKVLSDFYEVFAQELEDASDVDRIEIASMESDEICELCNSPMVYKFGRYGKFLACSNFPECKNTKPITVGTGVTCPKCKEGEIVERKSRRGRIFYGCNRYPQCDFTLWDKPTHDFCETCGSIMVEKTYKNGTVKKFCSNETCPTRPPKKTRKKKSEASEEPVKESKKSSKAKKEETTIES
(1690) DNA topoisomerase 1 [Brucella melitensis NI]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEILRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYPRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1691) DNA topoisomerase 1 [Brachyspira pilosicoli 95/1000]
1
MATKTKEKKTTKKKLVIVESPAKAKTINRYLGSDYVVLSSMGHLIDLPRSRLAIDVDNGFEPEYITIRGRAKILNDLKKEAKKSEEVLLAADDDREGESIAWHIGNKIRSVNSAVPIKRIVFHEITKDALKEAIDKPRDIDIAKVNAQKARRVLDRLIGYNLSPLLWEKIKRGLSAGRVQNVALLIICNREDEIETFVPVEYWTFGVFLKHKNKEFLAELQKYKGEKPDLKTKEDVDAIMEHLKDKTYTVSSIEIKDRLRNPTAPYTTSKLQQAASTSLGYNSSKTMQIAQTLYEGVSIAGEATGLITYMRTDSVRISPVAQEQARDFIQKEYGSNYLPPEPPNYSVKKNAQDAHEAIRPTNVFLTPDSIKEYLKPEQYKLYKLIWERFVSSQMLPAKMKNTRAVIVAGDCEFAVSSSKIEFDGFMKVLTIDKEDKEKASKMPSLSNGEVCDFVEHNPQQHFTTPPPRYTDASLVKILEESGIGRPSTYAPTIKTIISRHYVQRKGKQLVPTELGKLVNELISENFPELVNINFTAEMESKLDKIEDDNVEWNNILKEFYPHFLDTLKTATENIHNMKDFFNEETDFVCEKCGKKMIKRLGRYGYFIACSGFPECKNTKGISFGICPKCGGDITLKRSKRGREFYGCSNYPKCDFVSWDKPLLEPCPKCNGLMVEKNIKNKGLFKVCIKEDCGYSEEIKEE
(1693) DNA topoisomerase 1 [Pelodictyon phaeoclathratiforme BU-1]
1
MASKPSTPSARNRTLIVVESPSKAKTINKYLGDKYTVFASVGHIKDLPKKEIGLDFDHHYEPRYEIIPGKEKVVHQLKKLAAEADSILIATDPDREGEAIAWHISKEIGVTSKPVSRVLFNEITKTAIIAAIQAPRQIDDRLVRSQQTRQGLDKIVGYKISPFLWNVVLRGLSAGRVQSVALRLICEREAEISRFQIQEYWSIAAEFVTAGKESFKARLIRFEGDKPEIANQKQAEALAALIRKGNFAVREIAPRVQQRKQPLPFTTSLLQQAASNQLGFGSKKTMGVAQQLYEGIDLGKEGTTGLITYMRTDSTRIGEEAIAEARSYINQQFGKEYIGFGGAAKPGKNAQDAHEAIRPTSIFNKPDQVKPYLSADQFKLYELIWKRFLASMMSAAKIEQTRVDVEDSASKFLFRATGSRVLFPGFMRVYDDQKELDYEAQTSTKEEVEKELTVKLPERLAVNEPLALDDLDQKQSFTRPPARYSEATLVKDLDHFGIGRPSTYASIFSTLQDRRYVELEKKKIVPTELGKDVSLILVANFPDLFNVDFTAFMENELDKVASGEDEYEKVLDSFYKPLEAVLHLRKSNPIVPQNSEPVTCEKCGEGLMVVKWTANGKFFGCSCYPKCKNIKAISNNKAKPVDSAILCPSCKEGHMLLRSGRFGTFLACSGYPKCNTLLNLNKQRHIEPMKTPPVLTTLLCPKCGSPLYLRSGKRGLWLGCSKFPKCKGRLAWSTLDEKAQHHWEAIMAEHQKAHPTVQLTMIDGKAVPMTIPVDEIILKAEEAGLITSPSEEIVEITP
(1694) DNA topoisomerase 1 [Desulfosporosinus orientis DSM 765]
1
MSKTLVIVESPAKAKSISKFLGSRYTVKASMGHLRDLPKSQMGVDLENDFEPKYIAIRGRGDLIKELRAAAKSADRVFLASDPDREGEAIAWHLSYLLGLEQTDKIRIEFHEITKQAIQTAIKHSRHIDQDRVDAQQARRVLDRLVGYQLSPLLWRKIKKGLSAGRVQSVAVRLIDDREEEIRAFVSEEYWSLTAELQFAGGKFLAKLVKKSGKKISISNRTEMETVLEELKGKEFKVSDVRTKEKKRLPAPPFTTSSLQQEAHRKLGFSPKRTMMLAQQLYEGLDLGKEGTVGLITYMRTDSVKIADIAQTEAKEWILGNYGGDYYPPEPRQFTTKGRAQEAHEAIRPTLPLRTPDALKGILSRDQLRLYRLIWERFMASQMSVAVVDTLTVESLVDEYLFRANASTVRFPGFLAIYEEGNDDTEAKDEEQNSLTISVSPGEQLKLIKLQEKQHFTEPPPRYTEASLVRKMEEEGIGRPSTYAPTIETIQTRGYVVKEEKQLLLTELGDIVITLLKEHFPDIVNLEFTANLEEKLDLIEEGKAPWKAVVEEYYQPFSVTLAEAEEKIGKVKIEDQVSEEICENCGRNMVIKMGRYGKFLACPGFPECRNTKPLFEEVGTPCPNCSKPLVVRRSKKGRKFYGCLGYPECDFVSWEMPAPEPCPECGQLMVVKSTKRQKKHVCTNRECRHTIVIEEEG
(1699) DNA topoisomerase 1 [Sulfurimonas autotrophica DSM 16294]
1
MNLIIVESPAKAKTIKNFLGKDYDVIASKGHIRDLPKSRFGITLDEETHELVPKYSVAKENAPTVKEIKEKAKKADTIYIATDEDREGEAIGWHIAHAIKKDPLELPRIVFHEITKTAIKHALESARKIDMDMVNAQQARRLLDRIVGYKLSPLLASKIQKGLSGGRVQSSTLKLVVDREREIKAFVPQEYWSIDTVFKTNIDANLIKHKDKKLSKLSIENKEQAETITQSVKNDNFTIAKIETKQRKSSTPPPFMTSTLQQTASSKLGFTPKKTMMIAQTLYEGVKTPDGTSGVITYMRTDSLNLAQEAVGAVRGIIENRYGKKYLPKEPKIYTKKAKGAQEAHEAIRPTMLQFTPEVAQSFLKADEIKLYRLIYERFMACQMEDAIFEQQSIIFKGNENEFRASGRKLIFDGFYAVTGTEDKDKLLPTLKEGEKAEIQSVKPEQHFTEPPSRYSEASLIKKLEAEGVGRPSTYAPTIATLSNRTYVTIEKKQIIPTEIAFTVTEILEKNFPNIVDINFTAEMEEELDEIAEGKVDWQKLLLEFYEKFMKQIEEGKENIVSLKLAKPLGRTCPKCGEHELLLRSGRFGNFIACSGFPKCKYTEQCDEEGNAVEKKETTADEKCDKCGADMIVKNGRNGEFLACSNYPECKNTKSINVEEKVSETPCPDCGGKISLKNSRRGPFWGCENYPDCKFISKFEPTTIKCKEEGCSGVLAPRTYRNKEVYECVKCKARTPKEEIDTKK
(1703) DNA topoisomerase 1 [Nitratiruptor sp. SB155-2]
1
MGKNLIIVESPAKARTIKNFLGKEYEVIASKGHIRDLPKSSFGIKIEEDKFIPQYRVDKEHSQITKQLKELAKKADTVYIATDEDREGEAIGYHIAEAIGKKPQELPRIVFHEITKSAIQKALQNPRTIDMNRVNAQQTRRLLDRIVGYKLSPLLSSKIQRGLSAGRVQSAALKLVVDKEREIQAFKPQEYWSIDAIFNDTIEAALYEYMNKKIGKMDIKNEKEAQAIVDQVKNESFVVAKIEKKKRITKSPAPFMTSTLQQTASSKLGFSPKKTMMIAQKLYEGVQTPKGITGVITYMRTDSLNIAKEAQEAARDLIKKQFGEKYLPKKPKEYATKSKGAQEAHEAIRPTMLDFTPEVAKNYLSADELKLYTLIYNRFLASQMEDAVFETQTIYFKSPSATFKASGRKLIFDGFYKVLGNEDKDKLLPDLKEGEEAKLTKIEANQHFTEPPARYTEASLIKMLESLGIGRPSTYAPTIALLQARNYIELEKRAIKPTEIAFKVIEVLEKHFPEIVDSSFTAKMEEELDEIAEAKKDWQKVLKAFYDPFIELIEKGKKEIKSQKVAIPVGRNCPECGAELVKRKGRFGEFIACSAFPKCKYTEQIESEEKGPQESNEVCEKCGSPMVVKQGPRGSFLACSAYPKCKNTKPLAKNEPKKLDVKCPECGGEIVERFSRRGKFYGCSNYPKCTFVSKFEPVDKQCSECGYMMAKRTYRNKEVYECIKCKHREEVQ
(1709) DNA topoisomerase 1 [Bacillus clausii KSM-K16]
1
MSDYLVIVESPAKAKTIGKYLGKKYVVKASMGHVRDLPKSQMGVSVEDNYEPRYITIRGKGPVLKELKTAAKKAKRVYLAADPDREGEAIAWHLAHSLNIDENSDCRVVFNEITKTAIKDAFKHPRPINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKLITDREKEIQQFVPEEYWSITGTFLLGDEPFEAKFYGRNGKKESLTSEENVNEVLKQIKGKQFAVADVVKKERRRNPVSPFTTSSLQQEAARKLNFRAKKTMLIAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKQETYEYIRSTYGEEYARKGERKQKQDKNAQDAHEAIRPTSVKYEPKQLKEYLSRDQLRLYRLIWERLVASEMAPAIMDTMTVDLENNGVKFRANGSKVKFPGFMKVYIEGNDDNKKEEDRLLPALAKGQQVEKTEVTPNQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVALDEKRFVPTELGEIVLDLIVEFFPEILDVEFTAKMEEDLDSIEDGRDNWISIIDQFYQSFEKRLKVAEEEMEEVEIKDEPAGEDCEKCGHEMVYKMGRYGKFMACSNFPECRNTKAIVKEIGVTCPTCKQGNIVERKSKKRRIFYGCDRYPDCEFVSWDKPISRPCPKCQGLLVEKKSKKGVFVACTSCDYEEEKQ
(1714) DNA topoisomerase 1 [Eubacterium limosum KIST612]
1
MAKNLVIVESPAKAKTIKKYLPKGYEVQATMGHVIDLPKSRIGIDIEDHFKPDYIKIRGKGELLKKIKKEANKADNVLLATDPDREGEAISWHVANFLGIDLDTKCRIEFHEITKRAVNAAIENKRAVDMDLVDSQQARRILDRLVGYSLSPFLWKKVKKGLSGGRVQSVVTRIIVDREEEIAAFVPEEYWGLDLELKKDKDKNIFLSRFYSEDGKKKTIKNAEEAARLEQVVLHNPITVAGVKKRVRKQKPPLPFTTSTLQQEAYKVLGFTTQRTMRIAQQLYEGVEVAGKGLVGLISYIRTDSTRLADEAIAEAKDFIETNYGPDYQQSSAKKTVKKKNVQDAHEGIRPSSVFNLPEEVRDSLEKDQYKLYKLIWDRMVASQMADAEYYVTDVDVACANLLFKTKGEIMKFKGFTAVYRTASSAEKEEANRLPEFEDNEELNLVKINKEQKFTKPPARYTEASLVKILEEKGIGRPSTYAPTIATIKSRDYVEVVEKHFVPTELGITVTHLMKEYFEDIVNLTFTAEMEEKLDKVADGETDWVKLLESFYGGFKKELDHAQEAAAEVTIADPESDEICELCGRRMVIKKGKYGKFLACPGFPDCKNTKPYFEKTGGICPECGGDLVKRTSKKGRTFYSCSNYPNCEYMSWDMPVAEKCPECGQTMFQKGLGKRKKVYCAKCGFEKSADQQ
(1733) DNA topoisomerase 1 [Candidatus Methylomirabilis oxyfera]
1
MPKSLVVVESPAKAKTIEKYLGKGFVVTASMGHVRDLPAKSLSIDIAHDFAPQYEIIAGREKVMSALRKAAKTADAIYLAADPDREGEAICWHLQQELDAAKKPVHRVTFDEITKRAVREAFDHPSTIDQRLVDAQQARRILDRLVGYQISPLLWDKVKRGLSAGRVQSVALRLIADREREIKAFVKTEYWSVDVALEGRTPPSLRAGLYKIDGGRVSLPDQAQTDQVVRELREQEFRITDLTRKEKRRNPVPPFTTSKLQQEAVRKLRFTARRAMQIAQQLYEGIEVGEEGAVGLITYMRTDSVRVSQEAQAEAARYIAERFGQPFVPDRPPAYRSGRGAQEAHEAIRPTSVYRDPVSLRQFLTKDQLALYTLIWSRFVASQMPPALYDVTTVTIQGGRFTLRAGGRHQRFAGFMQVYIEGRDEAPETKPTEAKDETAEETAVEEEAELTLPPLEVGDPLRLLDVTPAQHFTQPPPRFTEATLVKELEERGIGRPSTYAAILSVIQNRDYVVKAQGKFRPTELGGIVVDLLVESFPRVMDYEFTARMETTLDEIEEGQKNWLEEMRRFYEPFSQWVKEAAVGMRNIKAMEEKTEEICERCGSGMVIRWGRFGRFLACTNYPECKGTRELTAELKGEHGTDEDTDVSAEAVTAPCENCGRPMVMKRGRFGPFLGCSGYPECKTIRKLSQAEAASARPAPQPTDEVCEKCGSPMVLREGRFGRFLSCSTYPTCKHIKPIAIGVKCPQCGSPLSERRTKRGRVFYGCTAYPKCAFAIWDRPIQEPCPQCGAAFLVEKKLKGGGVSIRCHAEGCAYAREADTTVQANA
(1736) DNA topoisomerase 1 [Desulfovibrio africanus str. Walvis Bay]
1
MAKNLIIVESPAKVKTIKKFLGRDYMVEASVGHVRDLPPNKIGVDEERGFTPDYKVIPGKQKVVAKLKAAADQAEHIYLAPDPDREGEAIAWHVAHLIGDKNKQVSRIQFNEITSRAVKEALDNPRPLDENLFHSQQARRILDRLVGYKLSPLLWSKVKRGISAGRVQSVALRIIVDRERERQAFRPEEYWVFKALLEGPEPPAFAAELWKVEGKKPSVGSGEQAQVLYDRVKDTPFVVSAIEEKERQRHPSPPFITSTLQQDASRRLGYTAKRTMSTAQRLYEGVELGESGVTALITYMRTDSVRVADEARDAAQAFIVETLGADYYPPKPRYFKTKSGAQDAHEAIRPVDVRVTPESVRKHLPADQYKLYTLIWQRFMASQMAAARLHDTTVTVDSGPAQWRAKGERVLFPGFLKVYGVDEATDEKTEGEGGESTSTKAAMLPKLEKGMQLTVRKLTKDQKFTQPPPRYTEASLVKELEEQGIGRPSTYAAIISTLLDRDYARLEEKKFVPSELGVTVVDLLTKHFQSLMDVHFTAGMEEQLDDVAGGKVNWVELLKHFTGDFYPTLDKAKDEMVQVKGGLETGIVCDLCGKPMNIRFGKNGEFLGCSGYPDCKGIKNFTRDEQGQIQIVERANEMPEKVGTCPDCGKDLVLKRSRTGSRFIACSGYPECKHAEPHSTGVTCPREGCTGQLVEKSSKRGKVFYSCSTYPKCNYATWDWPIAKPCPQCDSKILTIKTTKARGEHVACPEKACRFTRELEPDESVG
(1744) DNA topoisomerase 1 [Thioalkalivibrio sulfidophilus HL-EbGr7]
1
MSKHLVIVESPAKAKTIKKYLGPDFEVMASYGHVRDLVPKEGAVDPDHGFRMNYQVIDRNERHVESIVKALRKADSLLLATDPDREGEAISWHLYELLRERGVLDAKTVQRVVFYEITQRAVKEAIEQPRGLSFDLINAQQARRALDYLVGFKLSPLLWKKIKRGLSAGRVQSPALRMIVEREEEIERFQTREYWTLEADLDKSGQAFNAKLHTLDGKKLDQFDIADEVTASAARNTLLSAADGRLRVARIEKKQRRRNPAPPFTTSTLQQEAVRKLGFSASRAMRVAQQLYEGIDLGAGPIGLITYMRTDSVTLAGEAIAEIRRLIEQRYGRNTLPEHPRQYKTKAKNAQEAHEAVRPTSVMRAPEEVKRHLTTDQFKLYDLIWKRTVACQMQHATLDTVSADLAAGSERHLFRASGSSVRDPGFMAVYQEGKDDAKEESDERILPPLEEGDIVKLEALRAEQHFTEPPPRYTEASLVKALEEYGIGRPSTYASIISTLQQREYVEMDSRRFIPTDIGRIVNAFLTQHFTQYVDYDFTARLEDELDEISRGEKEWVPVMEGFWSSFKEQIEEKEATVTRAEAVQSRELGIDPKSGRPVSVRMGRYGPVVQIGTKDDEEKPRFAGLPPGKKMDAVTLEEALELFKLPRELGETPEGEPVSVNIGRFGPYVKFGSRYASLKPEDDPFSIELPRALELVAEKKEADANKYIRVFDEAGVQVVNGRYGPYITDGNKNARIPKDRDPKSLTLEECQALLAAAPERKGRRGVKKAAPKKKAAAPKKAAPKKKAAPRKKATAKKKAAPKKAAAKKNATSGGESGAGLTR
(1745) DNA topoisomerase 1 [Thermotoga petrophila RKU-1]
1
MNRKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGIDLEKDFEPEFVVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGKKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKTNLSAGRVQSATLKLVCDREREILRFVPKKYHKITVKFDGLTAEIDVKEKKFFDSETLKEIKSIDELVVEEKEVSLKNFSPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKDEARNLITEVFGEDYVGAKGAKRKGNTKIQDAHEAIRPTNVFMTPEEAGKYLNPDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWTTERNTGEFPFEEGESVKPVVVEIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTVVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLQEFYQSFSSVFDRNDRIVIDFPTNQKCSCGKEMRLSFGKYGFYLKCECGSTRSVRNDEIAVIDDGKIFLGRKDSESGSPDGRSIKGKRNLPEKRRKGKKSS
(1747) DNA topoisomerase 1 [Candidatus Liberibacter asiaticus str. psy62]
1
MNVIIVESPAKAKTISKYLGSNYKVLSSFGHIRDLPAKKGSVLPEKEFEMIWNIDPSSQKHLQNIIHAVKSSTILILATDPDREGEAISWHVLDVLRQKNLIEKTKIQRVSFNAITKQVVLNAMKSPRDINLDLVNAYLARRALDYLVGFNLSPILWQKLPGARSAGRVQSVALRLICNRENQIESFVSEEYWSLSVLLETPRNDKFTAHLTDFNGQRIEKKSISNKKEADDLISFVKKATYSVEKIENKPIKRNPWPAFTTSTLQQVASSRLGFSASHTMRIAQKLYEGIDVNGEIVGLITYMRTDGVHMSPDALEAVRRSITSHYGDHYLPEKPRIYSSKSKNAQEAHEAIRPNDFDFLPSKMKQFLDSDQFQLYNLIWKRSVASQMASAKFERTTVNIIATYNDQIGHLRTTGSLLCFDGFLKVWENQYDQEKNSEEDILLPYISANEQLIATETNASQHFTEPPPRYSESSLIKKMEEIGIGRPSTYATILETLYKRKYVIAEKRKILPQNTGRIVTAFLENFFSQYVEYDFTADLEEKLDEISTGKLNWKEVLHEFWEEFIEKIDSIKKLRISNVLDILNDTLSSVIFPPKENNEDSRTCPECHTHSLSLKLSSKYGAFVGCTNYPECKYTRQLTSNPQDIPEMKESVLLGNDLETKESVTLRSGRFGLYVQRGDGKDAKRCSLPKTWKSDSVDYDKAMSLLSLPREIGIHPETQKNIIAGTGKYGYYLNHDGAYTKLESIEQVLTIDLEQAISCITEKKKIEKSSRKNSKNQGHVIGTHPEGGSITVHNGRYGPYLHWKKINASLSKEESPDTVDLEKALKILNIKKQKKL
(1752) DNA topoisomerase 1 [Ketogulonicigenium vulgare WSH-001]
1
MPVVVVESPAKAKTINKYLGSDYQVLASYGHVRDLPPKDGSVDTDEDFAMTWEVDANSKKHIKAIADALKADPNLILATDPDREGEAISWHLVEALTDRKAIKKDTPVSRVVFNAITKSAVTEAMQNPRQVDAPLVEAYLARRALDYLVGFKLSPVLWRKLPGAKSAGRVQSVCLRVIVDREVEIEAFRAQEYWTVAAEIETPRGQIFTARLVTLGGKKLDKFDLGNQVAAEMAVQAVTSRALSVQGVEAKPAQRHPSAPFMTSTLQQEASRKFGMGAKATMSAAQRLYEAGLITYMRTDGIDMAPEAVMAARDAIRDKFGADYLPASPRMYKNKAKNAQEAHECIRPTDMTRGVEQQKIVDADQRKLYDLIYKRTIASQMAAARLERTTVDIGAADGQVGLRATGQVVLFDGFLAIYEEGRDDSTDEDEGRLPQMMQGEALKKLAVTPDQHFTQPPPRYTEATLVKRMEELGIGRPSTYASIVTTIQDRGYVQKDKNRLIPQDKGRLVTAFLENYFPRYVEYDFTAGLEDQLDKVSAGDADYKDVLRQFWRDFSAALNETSELRITDVLEKLNEVLSPIMFPPKPDGSDPRACPNCGNGHLSMRTARSGGAFIGCSNYPECRFTRPFGPPELAEGAIGPDGRLLGHDEGDPITLRDGRFGPYVQRGEATEEVPKPPRASLPKTWSPDEVTLERAVSLLNLPRPVGPHPEDGVLIEAGLGRFGPFIKHGSTYANLKSIDEVFEIGMNHAVELLAQKLAGGRGRTAVAKPLKELGDHPDGGAITVMPGRYGPYVKWEKVNATIPKDIEPEALTIEQALELITAKAGKKPAKKPAKKAATAKAATTKAKAAPKAKTTKAKAASADPAKPKRKTAKAAPDVVEDEA
(1754) DNA topoisomerase 1 [Methylovorus glucosetrophus SIP3-4]
1
MSKLLIVESPSKAKTLKKYLGSDFEVLASYGHVRDLIPKNGAVDPENDYAMKYEVIDRNSKHVDAIAKAVRASDAIYLATDPDREGEAISWHIAEILKDKKLIKDKLIKRVVFHEITKTAVQNAIASPRDISMPLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWTIHLESKKHQHLFDARLVQLDGSKVEQFTVTNETQQAEIVGKLLLASAGKTTVSRVEKKQKNRSPAAPFTTSTLQQEAVRKLGFTTSRAMRIAQQLYEGIDVGNGTVGLITYMRTDSFSMAAEAVMQIRDYIKRNFEPDYLPKSPIMYKTKAKNAQEAHEAIRPTDITRTPQSLKNYLTPEQFRLYEMIWKRALACQMAPAKFDAVSVDLAVGSDANLFRATGQTMIFPGFIAVYMEGQDDAEEEAEAKLPHLETGEVLDVNKIFGDQHFTEPPPRYSEASLVKVLEEYGIGRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTRYVDYGFTANLENELDDIAEGEREWVPVLDDFWQGFNKQLLEKANIDRAEITQEDIGEACPKCGKPLHSRLGRFGKFIGCSGYPECDYIRNTGSNAAASSEPVVMGHDAASDKDILLLNGPYGPYLQLGLPEEGSKKKPKRVSIPKEIPLANVDLEVAMKLIALPRDLGQHPETGKKIVANIGRFGPYVNHDGKFKSIPRSDSVFDIDLPRAVELLAQAKSGPAPLKDLGKHPTEDGNIEVYAGRYGPYVQHGKLRATLPSSEAPEELTMEEALALLAAKAAKEAPAKKPAAKKKTTAAKKPAAKPAAKKTTATKKPATRAKKTAVTES
(1755) DNA topoisomerase 1 [Rickettsia endosymbiont of Ixodes scapularis]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNKVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKDAKDLTEKLKSQNFYVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNVQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVCRESVDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVSLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKAALSNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCPSCKTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPSAIPNENKVLGTNKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPANLNQNDITLDIALKLLSLPLKIGVPKDSGEEIMIGYGKFGPYIKYMGKFISVPKKYDFLNLRLDDAMKLIEDNKRS
(1756) DNA topoisomerase 1 [Parvularcula bermudensis HTCC2503]
1
MQVVIVESPSKAKTINKYLGSDYKVLASYGHIRDLPSKNGSVDPEADFSMIWESDARSKKHVSDIVDAVKAADGVILATDPDREGEAISWHLLEVLDKKKALKDKSIQRVAFNAITKRAVEEAIANPRTIDQDLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLICERELEIEKFIAEEFWTLEANVSADDSPQFAARLVKLDGTKVEKFTLTTEEDGSRAKKAVEDAQFLIKSVEAKPTRRNPAAPFTTSTLQQEASRKLGFNARRTMQTAQRLYEGITIGGETTGLITYMRTDGIDMAPEAVMAVRDEIKSTFGADYLPSSPRMYKSKQKNAQEAHECIRPTNFARHPDALKQLDQDQYRLYDLIWKRAMACQMETARLEQTTIDIESRDGKTGLRATGSVVVFDGFLKLYAEGRDDTEDEKDRSLPKVSEGSDAQVTDPTPEQHFTQPPPRFTEASLVKRLEELGIGRPSTYASIISTLQDRSYVTMDKNRFIPDDKGRIVTAFLENFFGRYVEYDFTAKLEETLDDISNGEMAWKAFLRRFWDEFHARVEDMSDLRISEVLDALNEALGPHIFPQREDGRPPRECPTCGEGELSLKVGRYGAFIGCSRYPECKHTRPLGQSEQGNAPAEDRQLGVDPDTSQAVWLKSGRFGPYVQLGEPDPDTKEKPKRSSIPKSWDAASLDFDKAMKLLALPRDVGPHPEDGEMIEASLGRYGPYVKHGKLYANLESIDDVFDIGINRAVAVLEDKKANPRGRGRSAAKPQRELGNHPDTDELVAVYDGRYGPYVKHQKTNATIPQGVDPAEITLEQALELISAREAKKPTKKKKTAKKKSAKKPAKKKTTKKAAKKATKKTTNSAGKD
(1757) DNA topoisomerase 1 [Sideroxydans lithotrophicus ES-1]
1
MATNLLIVESPAKAKTLKKYLGKDFEVLASYGHVRDLIPKTGAVDPDDNFAMKYETIARNAKHVDAIAKAAAEADHIFLAPDPDREGEAIAWHISELLKGKRALKGKTMQRVVFYEITQSAVREAVAHPREISIPLVNAQQARRALDYLVGFNLSPLLWRKIRPGLSAGRVQSPALRLIVERELEIEKFKSQEYWSVHLDSQKNSIPFKAKLYQFQGKRMEQLTIGSQAEYDAIHAKLVDAKLPPKVVRVEKKGKQRSPAAPFTTSTLQQEAVRKLGMTSDRTMRTAQSLYEGVDIGGQTIGLITYMRTDSVNLANEAVAEMREYIKDNFAGDYLPVKQPVYKSKSKNAQEAHEAIRPTSILRTPDSLRDHLNIDQMRLYEMIWKRTLASQMSPARFDTVSVDIRLSSDDTLFRASGQTLVFPGFIGVYMEDVDDAEEEDSAKLPPLVEGDVLPVDKLYGEQHFTQPPPRFSEASLVKALEEYGIGRPSTYATIISTLQAREYATLDKKRFMPTDVGRVVIKFLNEHFTRYVDYGFTANLEDELDDISEGKRDWIPVLNEFWKGFNKLISEKKDVDRPGTEILEETCPKCGKPLSKRLGKRGSFIGCTGYPECDYTRSLGGEEDAGESRKELGQHPDTNQLVLLLRGPYGPYVQLGEMIEGEKTKPKRVSWPKELPLEQADLPSALKLLSLPREVGAHPETGKKVIVNIGRFGPYIGHDGKFKSIPRTDSIFDIGLDRSVELLAQARSGGATVLRTLGEHPDDKAPIEVCSGRYGPYVRHGKINATLPKDVTPEAVTLEEALEMIAAKAAKGGTGKAKTTRKPAAKKAAAKPKTTKEKAAAKPKTTVKKATVKTATAKTTVRKVAAKPAAKKTTKK
(1758) DNA topoisomerase 1 [Haliangium ochraceum DSM 14365]
1
MADQQAISKKRANDPANQADAADDNTSAKGATSEKSASKKAASPSKKTSTKKASTKKTAKKASTKKASTKKTTKKASAKKASAKKTAKKASAKKTTKKASAKKASAKKSASQEAAEDEGESAPKRTKSRSKATKQGKALVVVESPAKARTIGKYLGPDYTVKASVGHIKDLPKNKIGVDVDQAFEPEYVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAWHIAEEIKPINDNIKRILINEITKKGVNHAIANPTVLDTNKTDAQQARRILDRLVGYEISPILWKKVRRGLSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHRWDGAKAEPKTEAQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEASRKLRFSAKRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQGTYGPEFLPAKPHTYKSPKRAQDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYTLIWQRFVASQMAPAVYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAADQDKLLPHLEEGMAIHFDAIRPEQHFTQPPPRFTEASLVKELEERGIGRPSTYASIISTITDRGYVERREARFFPTELGAIVNDLLVESFPKIMDVDFTAAMEADLDKVEEGERDWRELLGGFYEPFRGNIEHAKENMRDVKREEIPTDHVCEKCGAPMVIKWGRNGSFLACQAYPDCRNTKEINRNPDGSFEIVPEQTTDETCSECGAPMVVKRGRFGAFLACSTYPECKNTQPISLGVDCPKDGCGGFLTEKRSRRGKPFYGCSNYSKTGCDFVTWDRPIAEACPVCEASFLVKKETRRGTTVRCLSCDYKTEQAGESAA
(1759) DNA topoisomerase 1 [Tetragenococcus halophilus NBRC 12172]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHVRDLPKSKMGIDVENNYEPYYITIRGKGDVIKDLKKHAKKAERVYLASDPDREGEAIAWHLSYILGLDPHDKNRVVFNEITKDAVKEAFKEPRTIDLDLIDAQQARRVLDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDREKEIRNFTPEEYWSIDGNFKKGRKKFKANFWGLDGKKKKLPNEDAVKEVTQRISGKDYNVTKVEKKERKRNPAAPFTTSSMQQEAARKLNFRTGKTMMVAQQLYEGISLGKGGTTGLITYMRTDSKRISDTAKQEATDFIEQTYGKNYAAHSNKKLKNAQGAQDAHEAIRPTSAMRSPEEIGKYLDKDQLKLYRLIWSRLIASQMKPAILDTVKATLDQNGVIFVANGSKVKFKGFMEVYVEGRDDGKKDKENVLPELASGDIVQSEDITPNQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLQTIQKRYYVKLTQKRFEPTELGEIVDNLIEDFFPEIVDASFTAGMEEDLDHIEEGKEEWVKVIDRFYQPFEKELETAEEKMEKIEIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECRNTKPIVKEIGVTCPKCQKGQVIERKSKKNRIFYGCDRYPDCDFISWNKPIGRNCPKCDHYLVEKKKKASKQVVCSNCDYKEDEQK
(1763) DNA topoisomerase 1 [Streptococcus oralis Uo5]
1
MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILDLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEINAFQPEEYWTIDGVFKKGTKQFQASFYGMNGKKMKLTTNEEVKEILSHLTSKDFTVDQVDKKERKRNAPLPYTTSTMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASYINDRFGSKYSKHGSKIKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTGAIFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMAVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWQRVIDAFYKPFSKEVAKAESEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGNSMLVAISQTAVTHKLLSKRLESSVQAVIKDKSSNEKPSVIVSSMVAIAIQNVNLLPGTNQLDVIVQNADTSLWRKRSVAVVNRLYVVMATTKKRKLNNTKSPENKFQALFT
(1768) DNA topoisomerase 1 [Thermomicrobium roseum DSM 5159]
1
MAGKTTKKTTKKTTAATSETTTKKTTRGTSRADGQALVIVESPAKARTIARFLGPGYTVKASMGHVRDLPKSKLGVDVAQNFQPTYTVLKEKLPVVKELQESVQRARELILATDPDREGEAIAWHLIEATRAHDKPVRRIVFHEITEEAIREALAHPRGIDMRLVNAQQARRVLDRLVGYEISPLLWRKVKSGLSAGRVQSVALRLVVDREREIQAFVPQEYWTIEVDLVPTGNGAQEPVPFAAALVRVRGEKPDLPNEEAARAVARELEASQYWVVSIKERQKQRRPAPPFITSTLQQEAGRKLRFPVSLTMQLAQQLYEGVELGPEGSVGLITYMRTDSTQVAASAQQRAREVIAARWGADFLPERPPVYAKKAKGAQEAHEAIRPTDPARDPESVRPYLTPRQYQLYRLIWERFIASQMAPAIYDTVTVEIAAGPTVGADAPYLLRATGSVVRFPGFLVVYREERDEDEVDELDQRPLPPLATGEVLRLLAVRPEQHFTQPPPRYSEATLVKTLEELGIGRPSTYAPTIETLKQRRYVVVEDRKLVPTELGMLVTDLLVQHFPDVVDVGFTSRLEEELDEIAAGERDWVPVVREFYEPFHRQVEEAEQTMERVRLADQPSGEVCELCGRPMVIKESRFGRFLSCSGFPECKNKRPLLEKIGVRCPQCGEGEIVVRRSRKGRTFYGCSRYPDCDFVSWERPTGERCPQCGGVLVVSVRRGQESVRCSSCSYRPAEEKAPVEA
(1771) DNA topoisomerase 1 [Micavibrio aeruginosavorus ARL-13]
1
MSASNLVIVESPSKAKTINKYLGPDYEVLASYGHVRDLPPKDGSVDPENGFAMLWELGDRAAKPVNDIRRAVKKAKALYLATDPDREGEAISWHVQELLKDEKLLEGKQVFRVTFNEITKKAVQEAFKNARDLDAPLVEAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRLICERESEIEKFRADEYWTIEARLHNRDGAPFTARLTHLSGNKLDKLDIGSEAQATAAANRIRGKNLVVQNVEKKQVRRFPPAPFITSTLQQEASRKLGFGASQTMRLAQRLYEGTEINGDTVGLITYMRTDGTTLSEDAVTQCRDVIKSNYGPKYLPDAPRLYKSKAKNAQEAHEAIRPTDLSRTPDEVRMYVDDQMARLYELIWKRTMASQMENAVMDQVGADISDGTTDVVLRATGSTVAFDGFLTLYQEGQDDDETDEENRRLPVLDKGDATKLIDVAQDQHFTQPPPRYSEASLVKKMEELGIGRPSTYASILQVLQDRDYVRLDKKRFIPEDRGRLVTTFLSKFFTRYVDYDFTATLEEELDAIAAGQAHWKDALAQFWKDFSKAVGDTKNLTITEVIDNLDAELGPHFFPVVEHGKDPRICPACNEGRLSLKLGKFGAFIGCANYPDCRYTRPLVVPSADENAEGGEAGGESGLAAQLANAPKILGHDPVTGRAVSLRRGPYGPYVQIDPPEAPPAPAVEEKAPEVEDGTAKKGKGKAKKKKETAEKPKRQGVPKGLKLEDIDLAAALKLLELPREVGLHPETKEMIKAGIGRFGPFLVHQGSYTSIPKGDDVLTIGINRAVDLIAAKAERAANGGGRRGGWGKKKAKADGDDAAPKKTAAKKKAPDKKAAAKKPAAKKTAAKKPAAKKTATKKPAAKE
(1774) DNA topoisomerase 1 [Acidobacterium capsulatum ATCC 51196]
1
MSKSLVIVESPAKAKTINKYLGKDFQVEASIGHIKDLPKNKLGVDVEKGTFEPELIVIPGKEKVVDKLRKLATKVDTIYLAPDPDREGEAIAAHLEDELKAVVKKPEAIRRITFNEITPKAVTAALDHARSVDRNLVDAQQTRRVLDRIVGYQISPLLWDKVRRGLSAGRVQTVALRLIVEREQQIKAFKPVEYWTIDAVLKTGGNPQEFTAHFIGIDGERARVETVDAPALPDQKLTDEVVAQLHKADWSVREVERKERKRNAPAPFTTSKLQQDASRQLGFNVKRTMGVAQRLYEGIEIGGDAVGLITYMRTDSTRVAPEAIEAVRGYIQKKVGKDYLPAAPNAFKSKKDAQDAHEAIRPADPNLHPDDIRKYLSDEQYKLYRLIWRRFVASQMMPAIFDQTTVEIAARADRRYDFRVTGSVMKFDGFLRVYEEVKEKKDADDEALANKLPALNNGDRLALSALKPEQHYTEPPPRYNEASLVKELEERGIGRPSTYATIINTIQDREYVQKMGGRTGRFIPTEIGTVVTGLLVKNFPYIFDTKYTARLEEELDDIEDGKERWTDLLNGFYDHFEDELKDAATNMEDIKRMEKPTDQKCDICGSPLVLKWGKFGSFYACSAYDKKKKDGCTFTKENYEAKPNLAAPSDEAEQEEEYCENCGRVMVLRNGPWGPFMACPGYNEDPPCKTVRRLNQKQQQKPPQPLDEKCPKCGEQLVLRHGQYGEFISCSGYPKCKYIKQNTIGMKCPQCKVGEIVEKKARRGNFFYGCSEYPKCDFTANYKPVDRKCPECGSAYLMEKTLKSGVYLVCPNNKKPSAEEETTTKRKKKGDTGEGVSCSFTERIGDAPSEAPAATATKPAAKPTAKTHGPVVEELAKV
(1775) DNA topoisomerase 1 [Chlamydophila pneumoniae LPCoLN]
1
MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDKQEVINHIRKLAAKCEKVYLSPDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEALKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEKARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGVDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAHEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQITPAIYDTLAVQITTDTEIDLRASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDVLIKEEVSQEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHKGKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAEDTPWDSPCPLCGGVMKVRHGRYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSEYPECSVIGNSIDAVITKYSGTEKIPYKKKTPIKKKSSAKTTKAAKAPSKKGKAKSSVKKSSEKKTGPLFLPSPDLAKMIGNEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATIIGPNPIDMFQLSKHLSQHLTKVSNDESSASS
(1776) DNA topoisomerase 1 [Caldicellulosiruptor bescii DSM 6725]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINKLKKYAQEAEKVYLATDPDREGEAISWHLATILGLDTNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRILDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDVQEFKAKFYGDKKGKIELKNQDHVQKIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRVSEEAQQAARSLIVQKFGKEYLPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSVYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEALKPIKLESKQHFTQPPSRYTEATLIKALEENGIGRPSTYAPTIQTILERGYVAKEDRFLKPTELGRIVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVKKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPVKNCPKCGSLMFEKGKKGNKKLVCSNENCAYQEKTGEKGE
(1780) DNA topoisomerase 1 [Mahella australiensis 50-1 BON]
1
MANNLVIVESPAKAKTISKFLGRGYKVEASMGHVRDLPKSQMGIDIEHGFEPKYITIRGKGEIVDKLKKQAKAVDRVLLATDPDREGEAISWHLAQLLDIDMDKACRIEFHEITKNAIKDALKHVRPIDKNLVDAQQARRVLDRLVGYSISPLLWRKIRKGLSAGRVQSVALRLICDRQQEIDNFVPQEYWTLTALLASDKGETLEARFYGKDTKKQELKDKESVDAIIKDINGSDFIVEKIERGQRKRKASAPFVTSTLQQEAARKLRFTAKKTMAVAQQLYEGVELGKEGMVGLITYMRTDSVRVSQEARREARNYIAERFGDNYVPDKPNEFRNRKGTQDAHEAIRPTYINYTPDYVKSFLSRDQYRLYELIYNRFIASQMSDAVYDTISVTIKAGDYVFKASGSTLIFPGHLALYMEGQDDDNDDKEQKLPPLEEGQRLILKKWMPEQHFTQPPPLYTEASLVKMLEEKGIGRPSTYAPIISTIVERGYVVREKRTLKPTELGILVNDMLKEHFPDIVDVSFTAQMEQMLDDVEEGQKDWHNIISEFYFPFKSVLDKADQSIEKVDVPDEQSDVICEKCGRRMVIKQGRYGKFLACPGFPECRNTKPLLEELKVTCPKCGGHIQIKRSKRGRKFYGCENYPKCDFVSWDEPTGELCPECGYPVVIKYSKNGRKYTRCSNKDCKYTGQKLAGEAK
(1784) DNA topoisomerase 1 [Laribacter hongkongensis HLHK9]
1
MPANLLIVESPSKAKPLKKYLGADFEVLASYGHVRDLVPKNGAVDPEHDFAMKYQIIAKNAKHVDAIASAVREADNIYLATDPDREGEAISWHLLQILQSKKLLKDKNVQRVVFHEITQNAVLDAVAHPRNILQELVDAQQARRALDYLVGFKLSPLLWKKIRRGLSAGRVQSPALRLICEREAEIRAFETREYWSVHLDSHKGRQKFSARLTDWLGRKLDQFDIPDETSQAGILAALAGKPASVTAVEKKKKSRSPAAPFTTSTLQQEAVRKLGMTTDRTMRTAQQLYEGVDVGQGQVGLITYMRTDAVVLSNDALTEIRYYIGEHFDADYLPKSPVSYKNKSKNAQEAHEAIRPTSIFRTPESVKPFLTPEQFKLYTMIWKRTLACQMAPAKFDTTAVDITVGDGVFRASGQVLTFPGFIAVYQEDKDSDDAAAGDDDEARLPVLEVGDELPVDKLYGEQHFTQPPPRYSEASLVKALEEYGIGRPSTYASIIKTLKDREYVTLEKKRFEPTDTGDIVNKFLTEHFEQYVDYNFTARLEDQLDDISNGKRQWVPVLDSFWQGFKKQLEEKEGISRAEVTTQQLDEACPKCGKPLNIRFGKRGRFIGCTGYPECDYTRNLNETAEEAAAAAAAEQEELVVIEDRVCPEDGGQLVIKKGRFGKFIGCANYPKCKHIEPLEKPRDTGVTCPVCKTGHLVEKKSRYGKLFYSCNTYPKCTYAVWNPPVAENCPQCGWPVLTIKTTKRRGTEKVCPQKECGWSEVIAPPAGKDEAPAD
(1786) DNA topoisomerase 1 [Campylobacter hominis ATCC BAA-381]
1
MKNLVVVESPAKAKTIGKFLGDNYNVIASKGHIRDLPKKTFGIKINEKHFEPVYEISEDHAKIVSEIKKLAKKADQIYLATDEDREGEAIAYHIATAIGKEPANLPRIVFHEITKTAIENAIKNPRALDTASVNAQQARRLLDRIVGYKLSPLLSQKIQKGLSAGRVQSSALKIVVDREREINAFKPEKFYTVNMIFKKDLEAEFVKFKNKKIEKMSIKTAKEADEIVQILCDEKFEVSKIESKDRKTNPYPPFMTSTLQQNASTALGFSPKKTMNLAQSLYEGVNAPNGGAITYMRTDSLNIAKEAIVSVRDMIKNEFGSEYLPKSANFYATKSKGAQEAHEAIRPTDLKFTPAIAAKSLPKDELRLYTLIYNRFVASQMNPCVSEIQNVFAKSGSSLFKILGRKVKFDGFYKIYGENDKDKILPDFKIGDELKVQNLKSVENQTEPPARYSEASLIKKLESLGIGRPSTYAPTLSLLISRKYVNTEKKQLVPTEIAFKIVEMLEQNFNNIVDSEFTSKMETKLDEIAEKSADWQEILADFYYPFMEKIAIGKKNIKSQKVAEPIGEKCPECGGELLKRNGRFGEFIACSNFPKCRYSRNLSGEQKIKKEPAKIGVKCPECGGEIVERVSKRGKFYGCSNYPKCNFISNYKPTNEKCPECGEMLFKKSLKKGDFLYCAKCKFQKAIDD
(1788) DNA topoisomerase 1 [Dictyoglomus thermophilum H-6-12]
1
MSKEKLIIVESPAKAKTIEKILGKDFKVLASYGHIRDLPEKELGVDIENGFKPKYVLLPSRKKIIDTIKDLSKKVEKLYLATDPDREGEAIAWHLVETLKLPKDKFTRIEFHEITPRAIQEAIRNPRDIDLDKVEAQQARRILDRLVGYELSPLLWEKVRRGLSAGRVQSVALKLICEREEEIEKFVPEEYWYIYGEFEDKDKIIYGKLVFYKEEEITIRNEKEAKRLIEVLNNLEYKIDRVVIKEEKKTPPLPFITSTLQQEASRRLGFPVSKTMKIAQSLYEGVDIGDERVGLITYMRTDSTRIAPEAREEAVTYIESVFGKEYVGKERKERKKLGMQDAHEAIRPTSVLRTPEKVKKYLTEDQYKLYKLIWERFLASQMANALYDVIEIDIKGGDYTFVSKGRKLKFAGFMSLYTEKEEEEEEEVNVDYIPQEGSDIDLINLTPKQFFTQPPPRYTEATLVRTLEKYGIGRPSTYATIIETLKERKYVEVSKKELVPTTLGKVVNEFLTKQFPHLIDVKFTAKMEEDLDKIESGEVKAIEVLEKFYPSFKEELERVSKNFGKIQVVEKTDEFCPICGRELVIRENKHGKYYACSAYPECKYTKPIYEEAHGKCPLCGGIVVKKKARKTGKVFWGCINYPNCSFASPYEPLDEKCPQCGSVLLKGNGFKKCSNENCNYIVWVGRRKRWKKSK
(1789) DNA topoisomerase 1 [Synechococcus elongatus PCC 7942]
1
MPKLVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASDIPTELKGEKWSNLGVDVENNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESISWHLLQLLQPRVPTKRMVFHEITQEAIQAALKNCRDVDQRLVHAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTLAGQRLATGNDFDESTGQIIAGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTTRKPAPPFTTSTLQQESNRKLRLSARETMRVAQSLYERGFITYMRTDSVHLSQQAIEAARSCVEQMYGKNYLSPQPRQFTTKSKNAQEAHEAIRPAGNTFRLPQETGLSGAEFALYDLIWKRTIASQMAEARQTMLSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAALEDREILLPALKVGDRPTCQELAAIGHETQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSNTLTPTFTAFAVTALLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFYRGDRGLEEQVKLRESEIDPAAARTVALEGLPAKVRIGRFGAYLEAEADGEPIKANLPKELTPADLDVQRVETLLRQKTEGPDQLGTHPETDEPIYLLTGAYGPYVQLGAATEEKPKPKRASLPKGMSLETISLEQAVGLLSLPRTLGEHPETGRRIQAGLGRFGPYVVCDLGGGEKDYRSLKADDDVLTIDLDRALELLAQPKKSRGRGKEPIREVGLHPDDQAPIQIFEGPYGLYLKHGKVNASLPEDEKPETISLETAVAALAAKAGQAKAKGGRRSTGTPKSGETKARTTKTTKKTTTRRTTSR
(1790) DNA topoisomerase 1 [Synechococcus elongatus PCC 7942]
1
MPKLVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASDIPTELKGEKWSNLGVDVENNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESISWHLLQLLQPRVPTKRMVFHEITQEAIQAALKNCRDVDQRLVHAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTLAGQRLATGNDFDESTGQIIAGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTTRKPAPPFTTSTLQQESNRKLRLSARETMRVAQSLYERGFITYMRTDSVHLSQQAIEAARSCVEQMYGKNYLSPQPRQFTTKSKNAQEAHEAIRPAGNTFRLPQETGLSGAEFALYDLIWKRTIASQMAEARQTMLSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAALEDREILLPALKVGDRPTCQELAAIGHETQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSNTLTPTFTAFAVTALLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFYRGDRGLEEQVKLRESEIDPAAARTVALEGLPAKVRIGRFGAYLEAEADGEPIKANLPKELTPADLDVQRVETLLRQKTEGPDQLGTHPETDEPIYLLTGAYGPYVQLGAATEEKPKPKRASLPKGMSLETISLEQAVGLLSLPRTLGEHPETGRRIQAGLGRFGPYVVCDLGGGEKDYRSLKADDDVLTIDLDRALELLAQPKKSRGRGKEPIREVGLHPDDQAPIQIFEGPYGLYLKHGKVNASLPEDEKPETISLETAVAALAAKAGQAKAKGGRRSTGTPKSGETKARTTKTTKKTTTRRTTSR
(1792) DNA topoisomerase 1 [Mesorhizobium loti MAFF303099]
1
MDVVVVESPAKAKTINKYLGKNYKVLASFGHVRDLPAKDGSVRPDEDFAMSWAVDTASGKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLKQKRALKDKPVSRVVFNAITKSSVLEAMANPRQIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFIREEYWQIAAILGTPRNETFEARLTAFERKKLQKLDIANKAQADDIKAMLEGATFKALSVEAKPTKRNPGPPFTTSTLQQAASSGLGFSATRTMQVAQRLYEGMEIGGETTGLITYMRTDGVQMAPEAIDAARDAIAKEFGPKYLPEKPRFYTTKAKNAQEAHEAIRPTDFMRTPASVRQYLDSDQMRLYELIWKRAIASQMQPAEIERTTVEIEAVNGARTAELRAVGSVVRFDGFIAAYTDQKDDDAEDEENRRLPEIRAGEQLARQAINATQHTTEPPPRYSEATLIKKLEELGIGRPSTYTAILKTLEDRDYVTIDKRRLVPQAKGRLLSAFLESFFERYVEYDFTASLEEKLDEISDGKLAWKDVLRDFWKDFSGAVADIKELRVTDVLDALNEELAPLVFPAREDGSNPRICPKCGTGNLSLKLGKFGAFVGCSNYPECSFTRQLGDAANPNGENGGGDDGTKVLGKDPYTAEEITLRSGRFGPYLQRGDGKDAKRSSLPKGWTPETIDHEKALALLALPRDIGKHPETSKMISAGLGRYGPFVLHDGTYANLDSIEDVFSIGLNRAVTVIAEKQSKGKGGRNGGTPAALKELGDHPDGGGKIVVRDGKYGPYVNFGKVNATLPKGKDPQSVTIEDALALIAEKEAKGGGGKKPFRKAAAAKAPAAKKTAARKPAAKKKG
(1801) DNA topoisomerase 1 [Mycoplasma synoviae 53]
1
MNKLVIVESPNKVKTIQKYLGNDYNVISCVGHIYKMKTSGPFGLGIDFENWEPLYEFDSTKKKVGKELKDSLKKAQMVYIATDPDREGESIGENLVSYLKLNDNYKRVTYNEITKDAILKAFDNPHDLNWALINAQKSRRMLDRIIGFRLSKLLQSKLQNAPSNASAGRVQSIALKLVIDREREILAFVPTKYWKLNAFLLNENSLKAQYFNEENSSGQKEWIFESQIKEVKEFFEKLKDKKVKVTKINVTEKKNKALVPFKQAAIYKRSPYSAAMTQSTLQKLYEGYGDGGLISYPRTDSTRLSQTFVNQAKKFIESKYGSDFVSSEVKGFTGDQDAHEAIRPTDLNLLPENLEKLYPTISSNEVNLYKLIYEHTLKALIKPPVIKSKQYIYQVDKYLFKNSFATVTFQGYYCVSAPEEKQEKDPNFEINQEVTVNNFAFEDLETKPTPRYNDGSLIEALDDIKVGRPSTFASTVKIIKDRQYVEVLDSNAIKPTDFGMIVLDKLVNNFPEIINEKYTAEVEGQLDLISENKLEKNQVMHDFYTKFNELYDQVASTMEKTRLEDNFLDEDCPDCSGKLLIRLNRKKQKFIGCKSFPNCTYTRSYEDPDAKKRYYRNYKNTNKSN
(1802) DNA topoisomerase 1 [Dichelobacter nodosus VCS1703A]
1
MSYKHLLIVESPAKAKTLHKYLGNDYEVLASYGHVRDLIPKNGAVEPENDFAMNYELIERNAKHVAQIEKALKNADELLLATDPDREGEAISWHLFELLQEKGVLAEKTVKRVVFYEITQRAILQAVSAPRDIEMNLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSPALRMIVEREREIDAFQAQEFWNITAHCQQKEEPFLAELTLFAGEKLEQFSFTDEQKTQTAIETLKKQAQGQLTVIDIVSKERKRNPAAPFTTSTLQQEAARKLRSSAQKTMRVAQKLYEAGYISYMRTDSVHLAQEAIEACRLLIEQQYGAVYVPPTPPVYTTKSKNAQEAHEAIRPTDITLEAAMLSAEMGADERQLYDLIRKRTLASQMAAAVMEQTSVDLSAGDTQNIFHATGSIIKFAGFMSVYLEDREESAEENMNLLPKMDIGDVIVLTDIIGSQHFTAPPPRFSEASLIKALEEYGIGRPSTYASIISTLQNREYVESSNRRFVPTTIGKVVNDFLTNHFQRYVDYDFTADLEDELDAIARGEQEWKPLLKDFWAQFKAQIEKKSEISREEVMQARELGMDPKTGKTVTARFGRFGPFVQIGSKDDAEKPLFASIPEDWDFEKISLENALELFKLPRNLGKTEEDEEIVINNGRFGPYVRFGRKFVSLPKDEDPLTISKERALELIALKKEEDRKKHIKEIKNGDDILQVLNGRFGPYVTNGSINASIPKHIEPAALTLEDALALLEKAQERKVNRKKKATEKTSEKKAKTTKTAKKAAPKKSTAKTKSTKQAEKGINHD
(1809) DNA topoisomerase 1 [Geobacillus sp. WCH70]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDINNGYEPKYITIRGKGPIIKELKTAAKKAKKVFLAADPDREGEAIAWHLANMLDLDIHSDCRVVFNEITKDAVKESFQHPRPINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIKQFQPEEYWTIQAEFVKGNETFTASFYGVDGQKLELKKEADVAAILQRINGNHFTVTSVAKKERKRNPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVSESARQEALSYIEATFGKEFVAQEKRKEKKNANAQDAHEAIRPTSAFREPEKVKPYLTRDQFRLYKLIWERFIASQMAAALLDTMSIELENEGVIFRASGSKVKFPGFMKVYVEGTDDQTDEQDRLLPDLQEGETVFSKDIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVLELMLEFFPEIIDVEFTAKMEKNLDEIEEGKVEWVKVVDEFYQEFEKRLQTAEKEMKEVEIKDEPAGVDCEVCGSPMVYKMGRFGKFVACSNFPECRNTKPIVKEIGVKCPKCREGNIVERSSKKKRIFYGCDRFPQCDFVSWDKPLARPCPKCGGLLVEKKLKKGVQVQCTACDYEEAPQS
(1811) DNA topoisomerase 1 [Magnetococcus marinus MC-1]
1
MTAVVIVESPAKAKTINKFLGRGYKVVATYGHIRDLPSKNGSVDTEHGFAMKYSVPKDSTKRVDELAKAVKGAEQVLLATDPDREGEAISWHVYEVLNEKKLLENVQVKRVVFHEITKTAIQDAVAHARDVDMDMVNAQQARRALDYLVGFNLSPLLWRKVRRGLSAGRVQSVALRLVCEREAEIQAFEAREYWSITALAAQAAQSAPRPFEARLAVADGEKLSKFSIGDEAYAKRLIKAVEKRPLYVSEIEKKQSKRNPAPPFITSTLQQEASRKLGFSAKKTMTVAQRLYEGMEVPTADGGKETVGLISYMRTDSVNLANEAIESIRKQIEIRYGKEYLPKSPRKYKSSAKNAQEAHEAIRPTDVIRTPEMLREILEKDQFRLYELIWKRTVACQMAQAKIDKVAANLSVDSQDPNAAYRFRATGSSVAFAGFMKVYMEGKDEVSAQDREDDDDDNESILPPLEVGQQLEQKSLDARQHFTEPPPRYTEATLVKVLESYGIGRPSTYAPTMSTLQDRGYVKLDARKFYPEDVGMVVNSYLTKHFSTYVDYNFTANLEDQLDAVSRGEKSWVPLMEDFWQPFIQQITLKDETTSKEEVTTEQIDEPCPKCGAPLSIKLGRFGKFKACTGYPECKHTEPLNKEEEVSRPEPELTDIPCDKCGKPMLIKEGRYGKYYGCSGAPECKNNQPLNKPRDTGVACPSCGQGTFLEKKSRRGKIFYSCSNYPKCKQALWDEPLEIPCPKCQAPFVTKKVTKTRGTEHICVAEGCDYKEVVEAPIKTSKQ
(1814) DNA topoisomerase 1 [Chlorobaculum parvum NCIB 8327]
1
MASKSATPSAKNRTLIVVESPSKARTINKYLGDNYTVYASVGHIKDLPKKEIGIDFDNHYEPRYEVIAGKEKVVRQLKKLAGEANEVLIATDPDREGEAIAWHISNEIEFAKKPVYRVLFNEITKNAIIESVNNPKQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVYRGLSAGRVQSVALRLICERENEIEAFEPQEYWTIYADFTTESGETFRTKLVKVKGKKPEIGSGEQAEAIVSAIRDRLFAVSEIVPKVLQRKQPLPFTTSLLQQAASNQLGFGSKKTMRAAQQLYEGIDLGSEGATGLITYMRTDSTRVSGEAIAQAHDYISQQFGEEYKGFGGQGKAGKNAQDAHEAIRPTSVYRTPESLRKHLSADQFKLYELIWKRFVASMMAPAKIEQTRVDVEDHQKEFVFRATGNKVLFPGFFKVYNDQQELEYEAQKSTRDEVEKEQMVKLPEKLSVEEQLRMSELDRKQSFTRPPARFTEASLVKELDNYGIGRPSTYAAIFSTLQERRYVELQKKKIVPTELGRDVSTILVANFPDLFNVKFTAEMEDELDKVASGDDEYEKVLDSFYRPLETVLSHRKSDPLIPQNREAERCDKCGEGHMIVKWTSSGKFLGCSNYPKCKNIKALATNKAKPKETGVKCPVCGEGHMLLRNGRFGPFLACSNYPKCNTLLNLSKQRHIEPIKTPPFTTDLECPKCGAPMYLRTGKRGLWLGCSKFPKCRGRLSWNSLDEATQTRLEKTMDEHLAAHPSVAITMLDGTPAPMNLPIDDIIIRAEDAGLINAPSEEVESEASA
(1815) DNA topoisomerase 1 [Sulfurimonas denitrificans DSM 1251]
1
MNLIIVESPAKAKTIKNFLGKEYEVIASKGHIRDLPKSRFGITVDENSHLIPAYSVAKENAATVKEITTLAKKSDIIYIATDEDREGEAIGWHIAHAIKKDPAELPRIVFHEITKTAIENALLNARKIDMDMVNAQQARRILDRVVGYKLSPLLSSKIQKGLSAGRVQSSTLKLVVDREREIRAFVAEEYWTIDTLFAKDIEASLISHMGEKLSKLSITNKADASSIVKSVKEDSFIISKIETKERRSATPPPFMTSTLQQVASSKLGFTPKKTMMVAQTLYEGVKTPSGTSGVITYMRTDSLNLAHEALTAVRGLIESRFGKKYLPAEPKIYTKKAKGAQEAHEAIRPTMLAFTPEVAASFLKPDEIKLYRLIYERFVSCQMNDAVFEQQSIIFSGANNEYKAIGRKLTFDGFYALTGAEDKDKLLPSLSEGQSAQIQKIESTQHFTEPPARYSEAALIKKLESEGIGRPSTYAPTIATLSNRTYVTIEKKQIIPTEMAFTVTEILEKNFSNIVDLSFTANMEEKLDEIAEGQNDWQKLLSDFYGDFLAQVEEGKTNIVSLKMATPLGRACPKCGEELLLRSGRFGEFIACSAFPKCKYTEQVEGEKKEGEENAQSSSSDEICDKCGKEMVTKNGRNGPFLACSGYPDCKNTKSINVEEKTSETPCPDCGGKISLKNSRRGPFWGCENYPTCKFISKFEPSKYKCRESGCDGALAFRVFRGKEIYECIKCKAKTPAQEIVAE
(1817) DNA topoisomerase 1 [Sinorhizobium meliloti 1021]
1
MFQRMSMNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLILATDPDREGEAISWHVLDLLRKKKVIGDKPVKRVVFNAITKKAVLDAMAEPRDIDASLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLPPKAIGNGEEANRLKSLLDGASYVVESVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIEAARQAIGSQFGERYLPEKPRFYSTKAKNAQEAHEAIRPTDFDRTPDQVRRFLDGDMLRLYDLVWKRGIASQMASAEIERTTAEIVADNAGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDEDGRLPEINARENLAKQKINASQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATVTTLIDRDYVEIDKRKLVPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLRDFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRICQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSNGDAEAAAANEPQSLGKDPHTGEEITLRNGRFGPYVQRGDGKEAKRASLPKGWTPAAIDHEKALALLSLPRDIGPHPESGKMISTGIGRYGPFVLHNGTYANLESVEDVFSIGLNRAISVLADKQSKGAGGGRASAAALKELGEHPDGGAITVRDGRFGPYVNWGKVNATLPRGKDPQSVTVEEALALIAEREAKGGVTKGKAAKGKPTGGKSAGTKSAKAASAGTAKAEKPKSAAKTKTKAAAKAKKD
(1820) DNA topoisomerase 1 [uncultured Termite group 1 bacterium phylotype Rs-D17]
1
MSKYLVIVESPTKEKTISKILGKDFTVKSSYGHIRDLPKNKLGIDIEDNFKPTYKNISKSKKLISDLKKKAENSDKIYLATDFDREGEAIAWHLKEALKLPESKISRITFHEITTEAILKAVKHPRNLDMKLVNSQQARRILDRLVGYKLSPLLWKKVKPGLSAGRVQSVAVMLICKREEEFKSFIPVEYWSIEAELSKLEENTTPFKSLLFSKNDVKFDKLSVKNKEQSDETLKELEGAKYIVKSVETKQRKRSPYAPYTTSTMQQDASRKLGFSASKTMSAAQKLYEGVHIGNSTNAGLITYMRTDSLNIAKSVQSETLKFIEYSYGSNFLPKIPRIYKTKTKGAQEAHEAIRPISPNRIPSEVKQYLSEDELKLYNLIWKRFLASQMADAVYNTVTAEILAKDYLFKSLESTLIFDGFLKVYNADDDEKETKKLPSLKSGEQLNLLRLLPLQHFTEPPPLYDVASLIKALEEHGIGRPSTYAPTIKTILDRLYVHLDGKKFVPTNRGIVVNNVLKDHFGNIINVEFTASVEEKLDKIAEDKAVWQNVLKDFYKPFKKDLSEAEKNLQKQKVQAQQTSEICPNCGKNMVIRYSRKVQFLGCSGYPECKTTLSLDKDGKIAAAPRETDMKCDKCGSHLIKKTGFAGKQYLSCKNYPECKTLYNINKDGNKIIYPEPEHTDIKCNKCGSEMLKKIGKRGPFLTCSAFPKCRNLQWIKTNKTPKSKTYKTVKLSEKKTTKK
(1821) DNA topoisomerase 1 [Candidatus Puniceispirillum marinum IMCC1322]
1
MKVVIVESPAKAKTINRYLGDGYKVLASYGHVCDLPSKDGSVSPENDFEMKWQISSGSEKHLKEITSALKNADKLILATDPDREGEAISWHVLEQLKAKKLVNDMPVERVVFNEVTKSAILTAMDNPRALDEELIDAYRARRALDYLVGFSISPVLWRKLPGSKSAGRVQSVALRLICEREAEIEAFITDEYWSVDTRMAKADGREFTARLTHIDGEKLGKLDIPNEAAAKAAEAKINAADLSVKTIETKRVKRNPSPPFTTSTLQQEASRKLGFSASRTMQIAQRLYEGINIGSDTTGLITYMRTDGVQLGKESIAALRDDIGSRFGNRYLPDSPRIYKTKAANAQEAHEAIRPTDITRDPEAMRSFLDHDQFRLYELIWKRTISSQMQSAELDQTGVDITDPAGTVTLRANGQVMVFDGYLSVYMESQDDKDEKDETRSNLLPEMKEGENLDTQNVSPEQHFTQPPPRFTDASLVKRMEELGIGRPSTYASIIQVLQNRDYVVKDRNRFIPEDRGRLVSTFLGNFFDRYVEYDFTAQLESQLDEVSAGRLDWKALLANFWRDFKSAIDGTKDLTITNVLDVLDEELGPHFFKADENGALMRSCPNCDDGRLGLKLGKFGAFVGCSNYPDCKFTRKLTDSDGTEDDAPVGDKNLGIDPATELPVFLRKGPYGPYVQIGDPETKKPKRASLPKGESAAAIDLDRALSLLALPREVGAHPETGDMIQAGLGRFGPYLKYQGGFTSLPADDDLLTVGINRAVDLLAESAKKKGRVLGAHPAKGDVYVKAGRYGAYVEHNKLRATLPKDVDIADVTLEQAIELLAEKAAKTPAKKPAKKAAAKKKAAPKKKAATKKKATAKKSAKKDS
(1827) DNA topoisomerase 1 [Helicobacter felis ATCC 49179]
1
MGKNTKLIIVESPTKAKTIAHFLDNSYEVIASKGHVRDLSKYAMGIKVQDNKFIPKYAIDKDHEEIVAQILQKAKNAQEIYIATDEDREGEAIGYHIAYLIDQAGNRSKDPLIEMRALEEQSQTKNPHPIFAFPRIVFHEITKTAILHALKHPKTLDVHKINAQLARRLLDRIVGFSLSSLLASKISKGMSAGRVQSAALKLVVDREREIKVFKPIIYYEITGTIAQASVSLQSYRHEKIKKQGLRDSKEALEMVANLSAQTYQVQEISTKEKNTPSPPPFMTSTLQQSASNQLGYSPSKTMSIAQKLYEGVMTSEGVSGVITYMRTDSLNIAKEAIESARVFIEQTYGAPYVPKKPKVYTSKNKSAQEAHEAIRPTNLAFTPAIAKDYLKPEEHKVYTLIYQRFLASQMSDARLESQSVSFACESLGAVFKASGHKLLFEGFYKVLGNGDKDTLLPSFTLHQEVRLEKLEAKECSTQPPARYSEASLIKTLESLGIGRPSTYAPTIALLLSRDYVSLQQKQLTPTPNAFSVIEILEKHFSEIVNATFSAGLEDKLDAIASHELNWQDMLLKFYTPFMAQIEEGKIQIASQKVSAPTGESCPKCGAPLVQRTGRYGVFVACSAYPKCKFIKSEVVQTEDLGVCEKCGAPMVSKRGRFGTFVACSAYPTCKNIRNEESKNTPALAKCPQCGGDVRAKRGKRGMFYGCDNYPSCKFISNYKPAPKPCPECGGLCVMKIYKTKPSVQECLQCHIQVEIEGEQV
(1830) DNA topoisomerase 1 [Brucella suis VBI22]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRITNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRNIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1832) DNA topoisomerase 1 [Gluconobacter oxydans 621H]
1
MTDVVVVESPAKAKTINKYLGSGYTVLASFGHVRDLPPKDGSVRPDENFAMSWQTDERGAKQISAITKALKGAKNLYLATDPDREGEAISWHVRSVLEEKKLLKNVDVHRVTFNEITKSAVTAAMAAPRELDRPLIDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFRPKEYWTVTGGFTTPGKAAFQARLTHLKSEKLDQFDLNNEQLAFGARDTVLGGQFTVRSVERKRTKRNPPPPFTTSTLQQEASRKLGMSAQTTMRTAQQLYEGVDLRGETTGLITYMRTDGVTMAKEAIGSIRGHIGKAFGDEYVPDYPRSYSTKAKNAQEAHEAIRPTDVFLTPQQVAHALTPEQKKLYELIWKRSVASQMQSAELDQVAVTLADASGQTLLRATGSTIAFDGFLKLYIEGRDDTKAEDEDGKLLPPMKEGDRLTTGAVEAEQHFTQPPPRYSEASLVKKMEEIGIGRPSTYASILGVLRDRNYVRLDARRFVPEDRGRLVTAFLTSFFERYVDTGFTASLEEQLDDISGGRADWHDVMAAFWHDFSAAVAQTKDLKISDVIDALDEDLGPHFFPPRPDGADPRVCTSCGTGRLGLRLGKFGAFIGCSNYPTCQFTRRLVAEEGDTEGLNDGPKVLGQDPETGEDVTIRRGPYGLYIQRGEPNPEDKKAKPKRTTIPKGLDGNTMTLEQALGLLSLPRLVGLHPETGEKIEAGLGRFGPYVKMGAIYGTLDKDDDVLTVGLNRAVDALAKKLASIRNLGPHPKDGEPVMIRKGRFGPYAQHGQLIANLPKGQDMDEVTLDEAVALLAEKGKPLKGGAKKTSAKKAAPKAAKAKKNVAAAEGDETAPKKVTKRSPAKSATKTKTTTPRKRKTVSDTSSEG
(1834) DNA topoisomerase 1 [Carboxydothermus hydrogenoformans Z-2901]
1
MKKLVIVESPAKAKTIGKFLGKEYVVKASMGHIRDLPTYRFGVNIEKDFAPTYEIIRGKKELIKELKEEAAKAEKVYIASDPDREGEAIAWHVKEVLDLEDNGDLRIEFNEITKDAVLQAIANPRGIDYNRVYAQQARRILDRIVGYKLSPLLWRKIKKGLSAGRVQSVAVRLICEREEEIEKFVPEEYWSLTAHLEAEKKPFKAKLSKYQNRKIEIKNKDEVERIIAEVSQRDFKVVKITKKLTKKSAPEPFITSTLQQEASKRLNFSAKKTMQIAQALYEGLEIGEYGVTGLVTYIRTDSTRVAEEAKAKAAAYIKNTFGEEYVGTEKKTKAPKGKIQDAHEAIRPTDIEKDPEKIKQYLTPDQYKLYKLIWERFVASQMSDAQYDVTTVDIEAGDYLFRATGSILRFPGFTKIYQVEEEEGEKEEKEKLPALMEGQSLTLLKLEPKQHFTEPPPRYTEATLIKALEEKGIGRPSTYAPILETILKRGYVEKDKKQLKPTELGRIVVDLLKEHFPDIIDVEFTAEMEEKLDQIEEGEKNWIEVLRNFYEPFNETLRQSYEKIEKIILPLEETEEKCPNCGRNLVVRTSRFGKFLACPGYPECKFIKPFVQKTGATCPRCGGEIIVKKSKKGRVFYGCSNYPSCDFVSWDLPSSKKCPNCQSVMVEKRPKKKPPYLLCTNPDCKHTEPLEEVQ
(1837) DNA topoisomerase 1 [Bacillus pumilus SAFR-032]
1
MADYLVIVESPAKAKTIERYLGKKYKVKASMGHIRDLPKSQLGVDTEHDFEPRYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLSSDCRVVFNEITKDAIKDSFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDRENEINEFKPEEYWTIDGTFLKGKESFEASFFGVNGKKHPLKTKEDVKEILSKLKGSKFSVEKVTKKERKRNPAVPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAIEEVSAFIDQTYGKNFLNTTKRTVKKNENAQDAHEAIRPTSTLRKPADVKHVLSRDQLRLYKLIWERFVASQMAPAVLDTMSVDLDNNGLTFRANGSKVKFPGFMKVYVEGKDDQLEEKDKMLPDLKEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFIPTELGEIVLNLIIEFFPEIINVEFTAKMEKELDSVEEGTIEWVRIIDSFYQDFAKRVEKAEAEMQEVEIEPEYAGVDCEECGHPMVYKMGRYGKFMACSNFPDCRNTKPIVKDIGVKCPTCHEGNIVERKSKKRRIFYGCDRFPECEFVSWDKPIERKCPKCENMLVEKKLKKGMQVQCVNCDYKEEQQK
(1841) DNA topoisomerase 1 [Petrotoga mobilis SJ95]
1
MPKKSTKSKGNSEESKYVVIVESPSKAKTIERYLGKEYKVIASKGHIRDLPKKEFGVDIEHDFEPIFQVIPGKEKVIQEIKKETKGRKVLLASDMDREGEAIAWHLSQILDLDPKEKNRIIFSEITKNAIKNSISNPQSLDLKKVDAQIARRILDRLVGYKISPLVWKVLKDYKTSAGRVQSAALKLIVDKERKIFIFKPKKYFNIYLEYKGQNIPLTKEDGKKIKPESITKIKKDQIFEYLKDKDFKLVNVEEKESIRKPPLPFITSTLQQAAVSTFNWASSKVMKIAQELYEGVETSEGSIAFITYMRTDSTRVSNEAQQAAINYLEKNYGKDYVGHYLSKNKKSNVQDAHEAIRPTDINMDVNNAKRLISSDHLKLYTLIWNRFMASQSAPSRYLEKTYTIEDNTNKYAFEITSKKCIFDGFEKFWNPNNKEVNFEIGKNDKITYDQLKFEEKETNPPNRYTEATLIKELESKGIGRPSTYATIISTLLQRKYVSKIAKSTLRPTTTGFVVTDFLETYFPEIVDVKFTANMEEDLDKIEDGKNKSKVVLEQFYKEFETFLSTASNNIKNKKEILHYESDVPCEKCGKNMKLNFGRYGLYLSCEECKETQKIPAESFGVTIKEKLYIKEYLQETLKIDKEENKIDEKCPICGGDLILKHGKFGEFIACSNYPECKYTRNVKARGKCPNCGGDIVKLKSKKGKTYFKCNSCSTMYWNEPSEYSCPNCGETLFYKTSKGKEKLYREKDKAYFDIEEIKQLTK
(1844) DNA topoisomerase 1 [Fervidobacterium nodosum Rt17-B1]
1
MAKSETKKTTKSSSSNEKADKTKKKQSQSSSQIIDNSNVSKVIIVESPAKAKTIENILGKEYKVISSKGHIRDLPQRDFGVDLKSLDVVFEIIPGKEGVVEQIKNTVKGKEVLLASDPDREGEAIAWHLATILNINGKNRITFSEITPKAIQEAVKSPREIDMKKVNAQLARRVLDRIVGYKISPLLWKIIKDAKSAGRVQSAALKILCERERERIKFVPQKYYKVWIEIAGLKANLTKIGNKKLKPTDITKEIADDVLKNVKSVNLIDIDVKEVKKNPPLPFITSTLQQDASSKLGFPVAKTMKIAQELYEGIDTPEGHIAFITYMRTDSTRISDEAKEAAKELISKKFGEDYLGDEIRKTSKEKSKAKVQDAHECIRPVNVNLLPEEAQKLLDKDHYRLYELIWKRFIASQMSSAIYKQYSYDFKSGDYIFEASIRERIFDGFESVYSTDNEISEEHKELKIGESYDVLPKTAEAETTPPDRYSEASLVKILESEGIGRPSTYATIIQTLLNRKYIIRNRKTLIPTVLGFVVNDYLEKKFPDIVDKGFTAEMEKQLDEIENGTAQWKDVIKNFMKEFGRDLENAGKEFFTINFETNKICETCKEPYHLRVGKYGLYLNCQKCNTNKSVKIDELGVLLEGKMYFIEEKDEKTEDESDTTQDEANEKKSGYSSKKNYYRYKTSSRKSAKNQSKQTNKSKKSK
(1846) DNA topoisomerase 1 [Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica)]
1
MEKNLVIVESPAKAKTIEKFLGKGFSVKSSIGHIRDMPKKNMGIDIENNFAPTYEITTDKKKVVADLRKAVKAAEKVYLATDEDREGEAIAWHLLEALNLPKDTPRIVFHEITESAITHAIVEPRTVDYQLVDAQQARRIIDRLVGFEISPVLWRKISGARSAGRVQSPVMRLVVEREREISQHITNSTYKVKAELTSEGGGLFEVKLSKEFESKKKVLDFINAFLSANLTVTSIEKKSYKRSPKPPFITSTLQQEASQKLGFSVKQTMTLAQNLYREGFITYMRTDSFTLSEIAIDVTGQIIVKEFGSEYHHIRRYKTKDTSAQKAHEAIRPTNLTKPSIFGIEDQAAKLYSLIYKRTLACQMSDAQLQKTQIKINISGLDEKFLANDEILTFPGFLRVYDYFSSENKLLPDLNKEDMLSLASFKARESFSRAKPRYTEASLVKKIEEMGIGRPSTFATMVSTVQDRNYVTKETREGVERGYQLIEIKDNQIIQSQPSEVTGAEKNKLFPTNVAYLLTDFLVKYFNNIIDYEFTAKLENDFDAIATQNISWQGVVKNFYTPFHKKIEDAADISREETHGMRELGTDPKSGKLVSVRFGRYGAFAQIGHKDDEDKPIFASLRDSLDIESITLDEALELFNMPRTVGETDDFGTIKANYGRFGPYIEYDKKYVSLKEDIPEKVSLEKALELIAYKEKFDAERIIKTFDDSNIKVLKGRFGPYIWNGKKKGKGQKNITIKKVFGNKNPVDLTLKECKKAVSGKIKAKAKPRKKKKVIKK
(1847) DNA topoisomerase 1 [Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]
1
MKLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGSVNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLSPILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQMASAKLERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRADQHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEPWLFPDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYPECKYTRGFGQGEDGVDDNEPVLLGYMPENSDDDGYMAFSDQGDILPANTASASETGVTDGGIAANAAFSGKGNSASHTDRDDLPFDPDEPASSTGNVASSQSRMTGDETASSGNSRDSSAHGVSTTAGIDAESQAGISNQALAGKNNAGRTAVSDNKGNNSSSTIAAARKGGSTDDNATVSDPDGDIGSGASSSGQDADNRLLSHRNGDIDSRAIPADHKDSSSDQNASHALSPDRNSDDASVSNSDKKIDSKAVSTGHDVGNAITSDNSPSDNVAHLASTPSSATSSVKVALETENNDTAASKADEQAKEEEESRKARAVTRRTGRFGPYIQLGEGKNAKRVSVPRDVNPREVDFSLASRLLALPREIGLHPESGKMIIAGTGRYGPYLNCDGKYARLSSTEELLDIDIDRAVVKLAEAAQNKGRTGATLSREPLKVFGDSPVTEKPVQLMNGRYGPYVTDGETNASLPKDTTPESLTFEEALALLEARAKMPKKKKTKKAAAKKPAAKKTTTKKAAPKKATTKTATPKSATTDNATSEDGDATPAKSPAKKAVAKKTTAKKPASKSATKKAPSSKTTAAKKTSKATPKDEVAE
(1848) DNA topoisomerase 1 [Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]
1
MKLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGSVNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLSPILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQMASAKLERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRADQHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEPWLFPDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYPECKYTRGFGQGEDGVDDNEPVLLGYMPENSDDDGYMAFSDQGDILPANTASASETGVTDGGIAANAAFSGKGNSASHTDRDDLPFDPDEPASSTGNVASSQSRMTGDETASSGNSRDSSAHGVSTTAGIDAESQAGISNQALAGKNNAGRTAVSDNKGNNSSSTIAAARKGGSTDDNATVSDPDGDIGSGASSSGQDADNRLLSHRNGDIDSRAIPADHKDSSSDQNASHALSPDRNSDDASVSNSDKKIDSKAVSTGHDVGNAITSDNSPSDNVAHLASTPSSATSSVKVALETENNDTAASKADEQAKEEEESRKARAVTRRTGRFGPYIQLGEGKNAKRVSVPRDVNPREVDFSLASRLLALPREIGLHPESGKMIIAGTGRYGPYLNCDGKYARLSSTEELLDIDIDRAVVKLAEAAQNKGRTGATLSREPLKVFGDSPVTEKPVQLMNGRYGPYVTDGETNASLPKDTTPESLTFEEALALLEARAKMPKKKKTKKAAAKKPAAKKTTTKKAAPKKATTKTATPKSATTDNATSEDGDATPAKSPAKKAVAKKTTAKKPASKSATKKAPSSKTTAAKKTSKATPKDEVAE
(1849) DNA topoisomerase 1 [Thioalkalimicrobium cyclicum ALM1]
1
MKNLVIVESPAKAKTIEQYLGKDFVVRSSYGHIRDLSKKGMGIDIPNRFLPSYEVSPDKKKTVTELRKLAKEADAVWLATDEDREGEAIAWHLAEALNLNVAETKRIVFHEITKPAITQAVANPRQVDLNLVNAQQARRILDRVVGFELSPILWKKIRTGLSAGRVQSVAVRLIVEREREIDAFTPVSSFKVSGELYTLNAQGQPDEMLPVKRLAAFDDEASAQAYLASLTGATFSVAQLDQKPAKRSPKPPFTTSTLQQEASQKLGFSVKQTMVIAQRLYESGKITYMRTDSVNLSEVAIGQAKDVITKRFGANYSHPRRYKTKQADAQEAHEAIRPTDFSVTEVGGERNEQRLYQLIWARALASQMSEAELLRSQVDIAIAPSNNELLVAKGEVVTFEGFMKVYNLDGQKDQDVLLPALKVGQNLQPVLLQAKQSFSRAPARYNEASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVIKEDREGSPRAVRLLSWQAGQVKAETLEEITGSEKNKLFPTDIAGIVNDFLVKNFGQVLDFQFTAQVEAKFDQIAMGQQAWQDMLEDFYHKFHPNVELAETLSREEAGQARLLGNDPKTGKPMLVKIGRFGPFVQLGDGENDEKPTFASLKPGQKMDTIKLEEALELFKLPRVLGDMPEAYHAAAADGTPFGVEQGQTITAKQGPFGPYLEYGEKQFAPIKGYDPLSITLEEAVLVIEAKIQADADKIVRSFPSTDVKILKGRWGPYITDTVTKVNAKIAKDEDPMELTLEECQTRLAAAPPPKKRGRAAAAKKPAAKRAPAKKTTTKKVTAKK
(1859) DNA topoisomerase 1 [Thermotoga sp. EMP]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGVDLEKDFEPEFAVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGRKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITVNFDGLTAEIDVKEKKFFDAETLKEIKSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPEEAGKYLNSDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFPFEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFDRNDRIVVDFPTNQKCSCGKEMRLSFGKYGFYLKCECGKTRSVRNDEIAVIDDGKIFLRRKDNESGTSDGRSVEGKGNLPEKRRKGKKGS
(1860) DNA topoisomerase 1 [Streptococcus salivarius 57.I]
1
MATATTTKTKTKTTKKTTAKKATKKRATPKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINELKKEAKKAKQVFLASDPDREGEAISWHLSHILGLEPDDKNRVVFNEITKDAVKNAFVEPRAIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGAFKKGAKKFQASFYGLDGKKLKLNNNDDVQAVLSRITSDDFNVDKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGINLGSGAQGLITYMRTDSTRISPVAQNQAAEFITERFGSKYSKHGSKVKNSSGAQDAHEAIRPSNVFQTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVTLSQNGVIFTANGSQIKFDGYMAVYNDSDKNKMLPDMAEGDTVKKVVTTPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVKLVAKRFEPTELGEIVNSLIVEFFPDIVDVKFTAEMEGKLDKVEIGKEQWQKVIDEFFKPFQKELEKAEEGIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVTCPTCGKGQVIERKTKRNRVFYGCDRYPDCEFTSWDIPVGRNCPKSGDYLVEKKVRGGGKQVICSNEECDYKESIVK
(1861) DNA topoisomerase 1 [Acidithiobacillus caldus SM-1]
1
MGQQLVVVESPAKAKTIEKYLGKDFTVLASYGHVRDLLPKEGAVDTEHGFAMRYAEIERNRRHVDAIAKALRSADALWLATDPDREGEAISWHLVELLREKGLLKDRAVHRVVFHEITQKAVREAIAHPREIAGDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLVCEREDEIEAFVRQEYWTIGAHLRRGEDPFTARLTHWQQQKLEQFDIVDGERAEEIRQAILADIAAGGLRVRKVERKNRQRQPAAPFTTSTLQQEASRKLGFSASRTMRVAQQLYEGVSIGTETVGLITYMRTDAVNLAEEALTSLRSFILGHYGADFLPAEARRYQTKSKNAQEAHEAIRPTDVQRTPEKLRGVLERDLWRLYDLIWKRAVACQMAAARLDLVAADLDADSHWTLRANGSTVTFPGFMAVYLEGRDEAAEEDEERLLPPLREGESVAVDAVLGEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVEVQQRRFVPTDLGRVVGRFLIQHFERYVDYGFTAAMEDELDAIARGEKQWQPVLAQFWGPFHELLEEKANVSRQEATSEALDEDCPECGKKLLVKLGRHGRFIACSGFPECHYARPLDGPRDAPEPVGRDCPDCGQPLVYKTGRYGRFISCSAYPQCKYIEALNKPKGTGITCPQCKVGELVEKRSRYGKIFYSCDTYPKCSYALWGPPLQRPCPRCAWPILYQKSTKRRGEELVCPQAECAFHFPAAAEDAEVQRLLADYTPPPPKDDADAAARPRRAAKTVKKAAAGPKSAAAAKTVRSKPTSRTANKSKTSKKPTVKA
(1863) DNA topoisomerase 1 [Campylobacter lari RM2100]
1
MKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDENFKPEYRISSDHSTLVKELKEKAKNAKQIYLATDEDREGEAIAYHIAKAINKDENSLPRIVFHEITKSAIENALNNPRHLDINSVNAQQARRLLDRIVGYKLSPLLNQKIQKGLSAGRVQSAALKIIVDREREIKAFTPLKYFSIDVIFKKDLEAELVEFQGQKIEKFTITNEDRAKLIFENCKNAKFKINNIESKDRKITPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVKTHQGIMGVITYMRTDSLNIAKEALEQVRKLIKDEFGKEYLPAKANIYTTKAKGAQEAHEAIRPTNLSFTPKLASEFLEKDEARLYTLIYNRFLASQMNPAISQTQNVYAKSNEASFKISGRKILFDGHYKVYGDMDKDKILPNLKLEDTLNIQNIEFNSHFTEPPSRYSEAGLVKKLENLGIGRPSTYAPTISLLSARDYVRIDKKQLIPNEIAFNVIEVLEQNFSDIVDSDFTFKMEESLDEIAEGKLDWQELLREFYFPFMRKIDEGKKNIKSQKTITKIDETCPDCGGELAIRKGRYGEFIACLNFPKCKYSRNLKQENKNEEKTQIKQVNSIGLTCPECKKGEIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGENLIIKELKKGTFLECLKCKIKKEI
(1867) DNA topoisomerase 1 [Herpetosiphon aurantiacus DSM 785]
1
MDHKLVIVESPAKAKTIQKYLGAGYRVMASMGHVRDLPKSKIGIDIDNDFSPVYEISEGKDKLIAELKREIKTADAIYLATDHDREGEAIAWHILQAANIGKRKPVYRITFNEITKDSIQHAIRNPREIDANLVDAQQARRVLDRLVGYKISPILWAKVRRGLSAGRVQSVAVRMVVEREREIESFVPKEYWTIEADLSPAGLKKLGKHDIFRAILHARNGKKLDKFAIPSKDAADAVLAALEGANYLVGTVTRKDKRRSPAPPFITSTLQQEASRKLGFSSKRTMQVAQKLYEGVDIGGKDGTVGLITYMRTDSTNVSVDAQTEARTLITELYGKEYVPAKPNIYKTKAKGAQEAHEAIRPTSVVRRPDQLKTALGRDEFRLYDLIWKRFMASQMAAAIFDSTSVDIGAGAGIKTAAGAPFTFRATGSVLKFNGFLAVYNVSLDEGDEDEDKEALLPPLNEGQALDLHDLFGEQHFTTPPPRYTEATLVKQMESEGIGRPSTYAPTISTIVAREYVELVEKKLMPTTLGRVVTDLLVEHFKDIVDYNFTSDMEQRLDDIAEGQRRWVPVLREFYDPFAVRLHAAETEMRNVKREEIKTELPCPQCGTHLVIKWGRNGEFLACSRYPECSWTGDLERDGDGGIHIASQPEIFGNTNCPECDNPMSLKKGRFGPFLACNNYPTCKGIRKVRAQGKDFVVIPPPKPTEEKCPKCNRPMVQKEGKFGPFLSCTGYPECRSIVRLTPNDAPTCPQCGEGKVVAKRARGGRTFFSCTRYPDCTYASNALPVAVSEEVA
(1868) DNA topoisomerase 1 [Staphylococcus epidermidis RP62A]
1
MADNLVIVESPAKAKTIEKYLGKRYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIRGKGPVVKDLKKHAKKAKKIFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKDSFKHPRGIEMDLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKSKFTAKFLHYKNKPYKLNNKDDVQRITEALNGDQFEITNVNRKEKTRYPAHPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISTSAKSEAQQYINDKYGEQYVSQRKSSGKQGDQDAHEAIRPTSTMRTPDDMKAFLTRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNDIKFRANGQTIKFKGFMTLYVEAKDDKENDKENKLPQLDKGDKVTATKIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFIPTELGEIVYEQVKEYFPEIIDVEFTVNMETLLDKIAEGDMNWRKVIGDFYNSFKQDVERAESEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPKCNEGDVVERKSKKNRIFYGCSRYPECDFISWDKPVGRDCPKCHHYLVNKKKGKSSQVVCSNCDYEEEVQK
(1876) DNA topoisomerase 1 [Rickettsia conorii str. Malish 7]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSHKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKAVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(1884) DNA topoisomerase 1 [Anaplasma marginale str. St. Maries]
1
MGVVIVESPSKAKTISKYLGGKYKVVASFGHVRDFPAKSGSVDPDDDFRMIYEIIPKSEKYIDKIVKTVSSEKSGIYLATDPDREGEAIAWHIVEVLRERSAIGEDVAVNRMVFNEVTKRAVNAAINDCRSINMDLVHAQQARRVLDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICEREHEIEQFDSKEYWDIEVLLKNNSGEKLTATLKHYNGEKLDKFAIPDADSANAIAEHVRNGTYHVASVEAKQTKRNPYPPFITSSLQQEASTKLGFSAKNTMMVAQKLYEGVDIGGETVGLITYMRTDGFYISTEAISYIRDTIKMQFGDKYLTKSPRQYVKKVKNAQEAHEAIRPTDITMTPDSLAKYLSDDQLKLYDLIWRRTMASQMESAVIDQVIVDIQSKDGSVVLHAVGSSLGFDGYQKVYGTDDDDKRKMLPQLKVGEACNLVEVSPNQHFTQPPPRYSEASLVKKMEEIGIGRPSTYAAIISVLQERGYTQLEQKKFVPSERGRIVNAFLTNFFSRYVEYDFTANLEEELDLISNGNMAWKEVLRRFWHKFISDVSTVKGIEVSEILKSITKDLEGYAFSSSSGEVVDRSCPGCGEGELMLNIGKYKAFLGCNRYPECKYTRGIGGESGVCRDEFPKVLGLDDATQEEIVLKNGPYGEYLQLGDNAQGKRVAVPQGIQEITLDVAKKLLSLPIVLGNYPDTAQDIKLGTGRFGPYVLYGGTYFSVKGREDFWNLTLEEAVDVINSQAQKKSRLLGLHDNGKEIYVCKGRYGFYLKCGDKNVAIKGKSDDITLEEAVSLLNQKA
Taxa distribution
Family tree
1