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Name	1
# topoisomerases	668
Sub-families	No subfamilies.

Topoisomerases

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Select all	Name	Family	Sequence
	(1) DNA topoisomerase 1 [Owenweeksia hongkongensis DSM 17368]	1	MPKNLVIVESPAKAKTIEKYLGKDYQVESSYGHIRDLVKKDMGIDVENNFAPSYAISSDKKEVVKKLKALAKKADTVWLASDEDREGEAIAWHLAEALGLNTLTTNRIVFHEITKGAIERAIQNPRTIDQNLVDAQQARRILDRLVGYELSPVLWKKVRAGLSAGRVQSVAVRLIVEREREIQNFESTSYFRVAAIFSNKEGKSFKAELNKRFDTEKEAKDFLEKCKSYKFSIGDIDTKPAKKSPAAPFTTSTLQQEAARKLYFNVGQTMSVAQRLYESGQITYMRTDSVNLSDEAMSLAENEIKKSYGKEYAKRRKYSNKSKGAQEAHEAIRPTDMSKHSGGADDQQRKLYDLIWKRTLASQMSDAQLERTVLKIETPEEKLEFVARGEVIKFEGFLKVYLEGTDDEDVEEQEGMLPAMSKGESLDNDNIIATQRFTQHPPRFTEASLVKKLEELGIGRPSTYAPTISTIQKREYIQKSDLEGTKRNYTQLILKDSKIAEKTLSETTGADKNKLMPTDIGSVVNDFLVEHFKKVLDYNFTAKVEAQFDEIASGNEKWAQMIDEFYSDFHPHLKDVEENSERASGERLLGQDPESGKNVYARIGRFGPMVQIGEADNEEKPKFASLQKTQSIDTITFDEAMDLFQLPRTLGEYKGEEIQANVGRFGPYVKFGDKFISLDKGENPMDTTLDRAIELIVAKEKADAPIAEYENLPVQKGVGRFGPFIKWNGIFINVNKKYDFDNLTQANIEELIEDKKKKEREKVIHNWEDAGIRLEKARWGRFNLIKGKVKVELPKTTDAAAFTLEEAESIIEKNAPKKKAKPKAKTKAAPKKSRAKK
	(2) DNA topoisomerase 1 [Pedobacter heparinus DSM 2366]	1	MAKNLLIVESPAKAKTIEGYLGKDFLVKSSYGHIRDLVKGDMAIDTANNFAQTYEVPSDKKQVVAELKKLAKDAEMVWLASDEDREGEAISWHLYETLGLKENKTKRIVFHEITKPAILKAIETPRSIDYNLVNAQQARRVLDRLVGFELSPVLWKKIKPSLSAGRVQSVAVRLIVDREREVNKFNAAAAFKITAEFVTGNGKELVKAELPQRFEKEADAEKFLNDCAGAGFSVDSLETKPAKRNPAAPFTTSTLQQEASRKLGYSVSRTMQIAQRLYESGRITYMRTDSVNLSETALQAAASEIRSAWGDKYHQPRTYKTKSAGAQEAHEAIRPTYFNQHTVPGDSSEQRLYELIWKRAIASQMSEALFEKTTAQIGISTRKEQLIAEGEVLKFDGFLKVYLESSDEEDAEDSEGNNMLPALSRGQALTLKVMNATERFSRPPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVVKEDRDGRQRSFAAIELSNGSVTKKTKTEITGAEKGKLFPTDIGEVVNDFLVEHFKGIVDFNFTANVEKEFDEIAQGLQEWTKMLHSFYTPFHLEVENTLETADRANGERLLGLDPATGKNVYTKVGRFGPLVQIGENDDEEKPRYASLSKSQSVGTVTLEEALEQFKLPFSLEDYQGKEVSVGVGRFGPYVKWGDAFISVPKNEDPLSIDQARAIEIIGEKITADAPVAHYQGMPVTKGTGRFGPFIKWNDLFINVPKAYNFDRLSQQDIEELIGKKIEKEANRFIQQWPAEKIAIENGRWGPFIRFGKEMLKLRKNPATNDKYTPEELASIALDEVKKLIVEQVPNAFEPKKKAAAKKTGAAKKAPAKKKAVAKK
	(3) DNA topoisomerase 1 [Oenococcus oeni PSU-1]	1	MVTKKKKAKKLVIVESPAKARTIENYLGRDYEVLASMGHIRDLPKSQLGVDTEHNYEPKYINIRGKAPLINSLKKAAKSASAVYVASDPDREGEAIAWHLGHILGLPDGGKNRVTFNEITKPAVKEAFKHPRGIEQDLVDAQQARRVLDRLVGYSISPILWQKVKRGLSAGRVQSVALGLILDKEKEIAAFVPKEYWSLNANFKAGKHEFSAEFYGTDGKKVKLDNQKSVSKILKRIDSSKDFKITDISTKESKRNAPNPFTTSSLQQTANSQLNYHARKTMQIAQGLYEGISLPKIGHVGLITYMRTDSTRLSETAQEMAKKFIVDKFGKEYYHRHNVVKKSENVQDAHEAIRPTDAERTPESLKEILTRDQYRLYNLIWSRFIASQMSEQKLENQSLMIEQNKTVWRATGIKVLFEGWTMALKTSSTKNNILPALKIGDLVQMVNNLPEQHFTQPPARYTEASLIKALEELGVGRPSTYAPTMDTIQRRGYIGFDQKKIVPTDLGDIVQDVVVKSFPEVTDKQFTSKIEDELDKVETGNVKWQKVIDEFYKPFSKEVDAAIENLEKVPIYDRIAPELCDICGSLMVIRRSRRGEFYACSRFPDCHGTKSIVEEIGMKCPKCGIGEVVIKRTKRGRIFYGCSRYPDCDFASWTKPKKNEETEENNETK
	(6) DNA topoisomerase 1 [Borrelia burgdorferi B31]	1	MQNKKLIIVESPTKAKTIKKFLDESFLVEACIGHVVDLPNNAKEIPKEYKKYEWANISIDYNNGFNPIYIIPSNKKPIVSKLKKLVKTINEIYLATDQDREGETIAFHLKEVLKIKNYKRMIFHEITETAITESLKNTRNIDMNLVNAGEARRILDRLYGYTISPLLWKKVAYGLSAGRVQSVGLKLLIEKEKTRINFKKANYYSILLQCKHEKKNLLLEAKLEEIDGKNIAEGKDFVNETGKLKNIAKTTIITQDLMIELEKELKNGQKIELISIETKKIKIPPPKPFTTSTLQQEINKRLKIGTKQIMQHAQKLYEHGYITYMRTDSHNIAKIAKDKITKIIKNKYGKEYIEEKDRIYEKEKMAQNAHEAIRPSEIFIPNETIEIESKTAKEIYKIIWDRTIISGMKDAIKENIKLTFKYKNLIFRSSFTKIIFDGFLKHTKEQDEHLNINFDLIKKGDTFSIVKMKTSEHETKAPFRYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNTLMPTIKGAAVINLLEKYFPVLIELNFTSNMEEKLDKIAIGKLDKIKYLSKFYNGKKGLKDTVMQLEPKIDSSEFRTVIESQKIENKNSINYTINIGKYGPYLIFKGHNYSINAKTPLENLYKKDEIEKIINEKELKPNILGVDPLTGLNVIFKNTIYGNIVQLGEDTHAPQEYTKKGKPKKLKIIKAKKASTKKIDPENITLELALKLLSLPKPIGKHPQTNEQIIAATGVFGDYIKTESGSIACSLKKDLKAYDITLDKAISLLNERANKVGIIVKTITFSKNKIGNKIYIYKKNDKFYAKIKRKKIDLPDNINLEEINEKYVFSLL
	(8) DNA topoisomerase 1 [Porphyromonas asaccharolytica DSM 20707]	1	MANQKNLVIVESPAKAKTIGKFLGADYKVLSSYGHIRDLKPSSFSVDVEHHFAPIYEIPADKQRLVSELRKAAKGSDIVWLASDEDREGEAIAWHLYQVLDLKDKETHRIAFHEITKSAIQHAIQNPRSINENLVDAQQARRVLDRIVGFELSPVLWRRVGPSLSAGRVQSVAVRLIVEREREILAFQPETSFAITTRLETKGGDTFSATLPENLPSEEAARQLMQRAIDSQSTFAVQQVEQKPGRRSPSAPFTTSTLQQEASRKLGMSVSNTMRVAQALYERGLITYMRTDSVNLSSLALHDAETVILEQWGADYYQRRHYHAKSKGAQEAHEAIRPTYLRNATIQGTKQEQALYDLIRKRTLASQMADARIERTIAQIASQGADSVRLEARGEVIVFDGFISAYTESRDDEEDTSGNVLPKLREGDSLQLREIEGRQSFTKPKPRYTEASLVRKMEELGIGRPSTYAPTIQTIQNREYVRRGESQGESRDVLYLNWQHGAGNTTIKSHKQKERYGGDRGRLVPTDMGIVVTDFLMENFSRVVDYNFTADVEEHFDKVAEGEAHWQDLIGTFYDKFHPIIEEQSQSGAKRYTGERLLGTDPVSGKPVIARIGRYGPMVQIGEAPDSSLPEEERERLKPRFASIPSNLLIETITLEEALKLFDLPRTVGEFEGGDVVAAVGRFGPYLRHKGAFTSIPKSSGLTPEEITLQEAIELIEEKRRKDAASLLKSFPEDPDIVIRDGRWGAYIKVGKKNYKLTKEQKAEPTKLTYAEVVAIIAEQDNETPKKGRATAKKATSTSKKSTTKKTTSTAKKAAPKRSAASKS
	(9) DNA topoisomerase 1 [Desulfotomaculum kuznetsovii DSM 6115]	1	MSKTLVIVESPAKAKSIGKLLGKKYTIKASMGHVRDLPKSQFGVDVEHGFTPKYITIRGKGEIIKELRTAVKKADRVLLASDPDREGEAIAWHLANVLEIDENAPCRIEFNEITKQAVQNAVKAPRPIDYNRVNAQQARRILDRLVGYKLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEINAFVPEEYWTLTAVFTRRGKDPFEAKLYKIGDKKAEIKNQAQIEEILKELKGVSYRVVKITRREKTRQPAPPFTTSSLQQEAYRKLNFTARKTMMVAQQLYEGLELGKEGPVGLVTYIRTDSTRVAVQAQMDARAYIQEKFGPGYVPEKPRQVAARGRAQDAHEAIRPTAVEREPEAIKQYLTPDQYKLYKLIWSRFVASQMSPAIIETTSIDITGGHYTFRAAGSVVKFPGFTRVYVESRDDETKEEEGVLPALSEGEALEVKSLTPKQHFTQPPPRYTDATLVKALEEKGIGRPSTYAPILETIIKRGYVVREKKQLVPTELGMVVVDLLKKHFPDIIDVEFTAQMEESLDRIEEGEMDWVRVIQDFYGPFQETLARAEEEIGQVTVSDEVSEEICEQCGRNMVVKMGRYGKFLACPGFPECRNTRPLLEPTGVPCPQCKGELVVRRSKKGRKFYGCSRYPDCDFVVWDEPSGEKCPRCGGILVIKKGRGEQEELECVNEQCRYRVDREKKAGSNGEAARDVAAGSKLVEEKPSFDSWHNDALLPLMRAKSGRTATRGTGGRS
	(17) DNA topoisomerase 1 [Bacteroides fragilis NCTC 9343]	1	MQKNLVIVESPAKAKTIEKFLGKDFKVLSSYGHIRDLKKKEFSIDIEKNFKPKYEIPAEKQELVNKLKEEASKAETVWLASDEDREGEAISWHLYEVLKLKPENTKRIVFHEITKTAILKAIEQPRDIDINLVNAQQARRILDRIVGFELSPVLWKKVKPALSAGRVQSVAVRLIVEREREIQAFKSEASYRVTAVFLVPDADGKLVEMKAELARRLKTKKEAQKFLESCKAATFSIEDIVTRPVKKSPAAPFTTSTLQQEAARKLGFTVAQTMMVAQKLYESGLITYMRTDSVNLSEYATEGSKVAIAQMMGDQYVHPRHFATKTKGAQEAHEAIRPTYMENQTIEGSAQERKLYDLVWKRTIASQMADAELEKTTATIGISNGNDKFTATGEVIKFDGFLRVYKESYDDDNEQEDESHLLPPLKKGQMLEHQGIVATERFTQRPSRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVEKGDKPGEERSFDILTLKDNQITDIKHTEIVGAEKSKLLPTDIGTVVNDFLTEYFPNILDYNFTANVEKQFDEIAEGDKKWTSIMKDFYKDFHPSVETTLATKTEHKVGERILGEEPKTGKPVSVKIGRFGPVVQIGTADDTDKPRFAQMKKGQSMETITLEEALDLFKLPRKVGEFEDKTVTIGTGRFGPYVYHNSKYVSLPKTYDPLEVTLDEAIELILAKREAEAKKHIKKFDEDAEMEILNGRYGPYIAYKGNNYKIPKDVVPVDLNYQTCLEIIKLQSEKAENAPKRGRYAKKK
	(19) DNA topoisomerase 1 [Deinococcus maricopensis DSM 21211]	1	MSTLVIVESPSKAKKIQAYLGAGYTVRASLGHIRDLPASKADIPARYAAEPWARLGIHVQDSFRPLYVISRGKAKVVRELRELARGANRVLLATDPDREGEAIAWHLMVALGLKGSVERMTFHEITREAIQAAARATRPLDYALVGAQEARRTLDRLVGYGVSPTLWTAVGPKLSAGRVQSAALAALAAREHARMAFVPADYWRVTARVGAGRPFTAVVLSVNGQRLATPKDFDAGTGQLAADALLMTPEQADRLVAFLRARDATVTGVERAPYTSRPPAPFTTSTLQQEASKALKFSPKHSMDVAQRLYENGFITYMRTDSPALSDEALQAAREAATALFSEGSVPARPRTYAARGANAQEAHEAIRPAGRSFRAPDDTPLTGDERALYDLIYRRTVASQMTDLTGTRTVMHLKVGAVALGATGRVVHDPGFTRLYQDASEGDGDETQALPDAEVGAVLPVRDAAAEERKTPAPGRFTEASLVRALERAGVGRPSTYASILSTLDARGYTRVVRRQLTVTWVGLLVSAYLAGSFADLVDAGFTASMEADLDRIAGGALTREAYLTRFWSEGLAGTIGRAGRAAPVLTVPRVPGATVTVQDGTPLLRLHGRSAPLPADLVPDDLTPDVAEQVLNGERKAAQRASGGKRARSGGARTSRARSSRKAARPK
	(20) DNA topoisomerase 1 [Pseudovibrio sp. FO-BEG1]	1	MESPAKAKTINKYLGKDYTVLASYGHVRDLPPKDGSVLPDDDFAMSWSVDSKSQKRLSDIASAVKEADRLILATDPDREGEAISWHVLEVLKKKRVLKDKKVERVVFNAITKSSILEAMKNPRELDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCQRENEIETFLSQEYWSILANLNTPENAPVQARLTGFDGQKITRLDIKNEQEATTIKQMLDGANFSVSNVESKPQRRNPYAPFTTSTLQQEASRKLGFAAARTMQVAQKLYEGANIGGETTGLITYMRTDGVQIAPEAITSARGVIASRYGDEYVPEKPRMYSSKAKNAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIWKRTIASQMESAVLERTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESKRLPPMTRGDSLGRKGIEANQHFTEPPPRFTEATLVKKMEELGIGRPSTYAATLQTLRDRGYVELDKKRLIPQDKGRLVTAFLEDFFNRYVEYDFTASLEDQLDKISAGDLEWKAVLRDFWNPFHEICDEVIKRSNTEVLDALNETLKAHVFPDKEDGSDPRKCPKCDTGRLSLKVSRFGAFVGCSNYNKDKKDGKEPNENPPHCDYTRQLTSGGDSDAGAAADGPQVLGIDPETGLEVSLRTGRFGPYVQLGEEAKPKRSSLPRGWSTADLDLEKALQLLSLPREVGTHPEDGKTISAGLGRFGPFVLHDGTYANLDSPDEVFSVGINRAVTLLAEKRAKGGGRGAAAKPLKELGNHPDGGAINVYSGRYGPYVKWEKINATLPKDVAPEAVTLEQAIELVNAKAATKGKKKAPAKKAAAKKTTAKKAAPKGALKEFGDHPDGGAMELRDSGRLGVRIKWGKEFVSLPKGTDPETVTREQAIELINAKKG
	(21) DNA topoisomerase 1 [Chlamydophila pecorum E58]	1	MSRQIQFMKKSLIIVESPAKIKTLKKFLGGNFVFASSIGHVVDLPAKEFGIDVDHDFEPLYQVLPEKQEVIRQIQKLAEQCDKVYLSPDPDREGEAIAWHIANQLPAHLSVQRVSFNAITKRAVTEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIQVLLQDPKTKKSFWAHLYSVEGKKLEKELPKEKTENDVLLINSKERAQKYADLLESASYKVVRIEAKEKRRHALPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGIDINEDTVGLITYMRTDSVRVDPEALHSVRSYIHTAFGSEYLPEKANVYSTKKMTQDAHEAIRPTDIHLSPESLAGKLSEDQHKLYSLIWKRFVASQMAPAIYDTLAVQISTDVHIDLRASGSLLKFKGFLVVYEEKSDDENDQEDLHPLPPLHAQDLLNKERVSAEQAFTRPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWEQFLPVVTTAEKEAVIPRITTDIECPKCHQGKLIKIWSKNGYFYGCSAYPDCDHRTSEEELSFKKEDYAADTPWDSPCPICQSPMKVRHGRYGSFLGCENYPTCRGTITLRKHGEEAEQEDPVPCPALGCSGKLLKKRSRYNKNFYSCSEYPHCSVIGNSIDAVLTKYTGTPKTPYEKKPSKKEAKKSTKTIKKAPAVKKASASTKNSPLLVPSPALASMIGDAPLSRGEATKKVWEYIKAHNLQSPENKKLLLPDEKFSAIIGNAPIDMFALPKLLSAHLKKKEG

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