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Family 3
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Name
3
# topoisomerases
321
Sub-families
No subfamilies.
Topoisomerases
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Name
Family
Sequence
(11) DNA topoisomerase 1 [Mycoplasma hominis ATCC 23114]
3
MENKIMIVESPNKVNTIQKIVGDNIKVLSSIGHILKMSTSGIGGLGIDFENWEPKMVIDPSKRKIVSELKEAAKNASEVLIATDPDREGEAIANNLVNTLKVQDKYKRVKYNEITPDAINYAIENPLTIDENLVNAQKARRILDRIIGFKLSQLIQRKVKNTPTNPSAGRVQSIALKLVVDKEEEIAKFIPTLYSKIEAHTADEQIANFVYRDNLDFVGENEWIKREKVDDILAQLNQNKSLKVIDFKKSIRSEAMVVPFKQSILYKESQYSSATVQIAAQKLFEMGLISYPRTDSTRLSSIFIEKSQKFIAQKYGKEYIATEIKGFSGDQDAHEAIRPTDISLLATEAQQKFNLSNEETNVYKLIYEKTLMALMATPKREIYQYELKNGQYNFKMSYSKIIFDGYYKIFDKKQESIIPNYKVGDIIKVLEFVKLDKETKAPARYNDGSLIKMLDDIKVGRPSTFATTVKIIKDRLFVETKNNSLYPTDYGKLVLEKLIQGFPTTINEEYTASVENQLDLISEGLSDYKVLLKDFWNNFNLQLQNVNETMETDFLPQEILQEKCPLCGHDLLYRYTKSKHQKFIGCSNFSSCRYIRNIDNEKPKFFKRRYNK
(13) DNA topoisomerase 1 [Halalkalicoccus jeotgali B3]
3
MDLIITEKDNAARRIAAILSGESAEVERQNGVNVYRWGGKRCIGLSGHVVAVDFPSEYSDWRDVEPVELIGAAVEKTPTQENIVRTVRLLARDANRVTIATDYDREGELIGKEAYEIVRDVNDGAEIDRVRFSSITDGEVHSAFDDPDEIDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGDDFISVGRVQTPTLKLIVDREREIEAFDPEAYWEIFANLVKGEESFDAQYFYRDEDGNEAERVWDGQRAEAVYETLREASEARVESVSRRTRTDAPPAPFNTTQFIRAASSIGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPEDLDPRELLDAFTGNRTFGEDAETLLEREEITPTEGDEETTDHPPIHPTEELPTKGELSDAEWEVYELVVRRFFATVADSARWEHLKVVLEVGEHRLKANGKRLVEPGYHAVYPYFSTNENVVPDVEEGESLALTEIRIEDKETQPPRRYGQSRLIETMEEMGIGTKSTRHNTIEKLYDRGYIENDSPRPTKLATAVVEAGEEYADRVVSEAMTAQLEDDMQAIAAGEKDLDEVAGESREMLERVFDDLMESREEIGDHLQKSLKADKTLGPCPESGHDLLVRRSRRGSYFVGCDGYPDCEYTLPLPNTGKPLILEATCEEHDLRHVKMLAGRGTFVHGCPQCKADEADEEEDRVIGACPECGEGSIPPSSRDGEDPAATAEDGQPVEADGGELAIKQLRNGSRLVGCTRYPDCDYSLPLPRRGDIEITDERCEEHGLPELLVHSGDEPWELGCPICNYREYQERENDSGTDLESIEGVGAKTAEKLAAAGVESVSDLQDAEAETVANEVEGISADRVRKWQAKAG
(14) DNA topoisomerase 1 [Halalkalicoccus jeotgali B3]
3
MDLIITEKDNAARRIAAILSGESAEVERQNGVNVYRWGGKRCIGLSGHVVAVDFPSEYSDWRDVEPVELIGAAVEKTPTQENIVRTVRLLARDANRVTIATDYDREGELIGKEAYEIVRDVNDGAEIDRVRFSSITDGEVHSAFDDPDEIDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGDDFISVGRVQTPTLKLIVDREREIEAFDPEAYWEIFANLVKGEESFDAQYFYRDEDGNEAERVWDGQRAEAVYETLREASEARVESVSRRTRTDAPPAPFNTTQFIRAASSIGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPEDLDPRELLDAFTGNRTFGEDAETLLEREEITPTEGDEETTDHPPIHPTEELPTKGELSDAEWEVYELVVRRFFATVADSARWEHLKVVLEVGEHRLKANGKRLVEPGYHAVYPYFSTNENVVPDVEEGESLALTEIRIEDKETQPPRRYGQSRLIETMEEMGIGTKSTRHNTIEKLYDRGYIENDSPRPTKLATAVVEAGEEYADRVVSEAMTAQLEDDMQAIAAGEKDLDEVAGESREMLERVFDDLMESREEIGDHLQKSLKADKTLGPCPESGHDLLVRRSRRGSYFVGCDGYPDCEYTLPLPNTGKPLILEATCEEHDLRHVKMLAGRGTFVHGCPQCKADEADEEEDRVIGACPECGEGSIPPSSRDGEDPAATAEDGQPVEADGGELAIKQLRNGSRLVGCTRYPDCDYSLPLPRRGDIEITDERCEEHGLPELLVHSGDEPWELGCPICNYREYQERENDSGTDLESIEGVGAKTAEKLAAAGVESVSDLQDAEAETVANEVEGISADRVRKWQAKAG
(16) DNA topoisomerase 1 [Archaeoglobus veneficus SNP6]
3
MGWLIITEKHNTARRIASILFNDVKQLKKYGVSYYHSPSSNAYVVGLKGHIVELDFPKEYNSWKNVPLRSLLRAELVKEVKEKGIARLLKELAREVDRVTVATDYDREGELIGFEALEIVKQVNPDVKVDRAKYSAITPADIKKAFSNPSKVDINLAKAAETRQRIDLIWGAVLTRLISISSGRMGRDFLSVGRVQSPTLRLIVEREKEIENFRPTPYWEIVAEFCNGECFTAKHVERFTDVAKAKAAFKKIGNTAAVRTFEKKERKEARPTPFNTTEFLREASKFMSPDRAMNVAETLYMNGYISYPRTDNTIYPPTLNLKAIATSFLNSDFEKEAKIVLSQPSIKPSRGKKESKDHPPIYPTAVAKKGELSKEEWTIYELVVRRFLATLAPEAIWEVKRVEIDANGELFRATGRRLLSPGWRAIYIYSKAEEVSIPDLTVGQILRIKNKELLEKETKPPGRYTTGNLIRIMEKLGLGTKSTRHEIIKKLYSRKYVYGNPLRPTQTAFAVIEALKSNAETITLPDMTSKLEKDMDAIAEGKLSDEEVVEESVRFLDEILSNIDVKELSKSLREGVKKDKVVGKCPECGRELVIRKTKGKKRFIGCSGYPACSFTLPLPQNGTLYITAKECEKHSIKKIKIRTKKGYWDLGCPYCNYLEWKAKQDKA
(30) DNA topoisomerase III, putative [Candida dubliniensis CD36]
3
MKILCVAEKPSIAKAVANILGGGRTSLRDSSEKFIKNYDFTFTFKPEDGPCQVTMTSVVGHITNLEFESAFAWGKCVPGRLFDADILTVITKKAVHENIAKEARNADKLMIWTDCDREGEYIGFEIMNAAKKYNRNLELNNIWRAKFSHLERNHIIRAAKNPVNLDMSAVAAVSCRMEVDFRVGTSFTRLLTDQLRQKGIIDGTQVASYGTCQFPTLGFVVDRYKRVKNFIPEPFWHIEVETRKENKKTVFNWVRGHFFDKLYVVMLYEQCCKSGEYGIISKIESKRKPNFRPFPLTTVELQKDCARFFKMSAKAALEAAEKLYNQGFLSYPRTETDRFAKETDFRSLLEVHKQDSRWGSYTTELLSQGYQVPRSGSHDDKAHPPIHPIKYVSLDTLKSINEKKVYEYVVRRFIACCSKDAVGMQTVATLKWGDEFFTANGLMVLEKNYLDVYIYKKWESSKQLPKFTEGERIKLASGVLKEGKTSPPNHMTEPELIALMDANGIGTDATIAEHIHKIENRGYIAKSKKGKNEFIVPSLLGMGLIDGLDKMEFEDISLSKPFLRKSLERSLEEIATGSRSKVDVLNTTISVYLDAFGVCSHQILVLCNECRRVLRGNSSNNNNNNSNNNT
(32) DNA topoisomerase 1 [Methanothermus fervidus DSM 2088]
3
MTLVNEVIICEKPQAAEKIANSLSSSTKKKKYKNVPYWEIKKTDKKILVVPAVGHLYTLAPSNKKKDYFFDLEWTPVYLVDKKRKYIKNYIDAIKKLGKKADRYIHACDYDIEGTLIGYNVLRYCIGKKSLKKSLRMKFSTLTKRDIRKAYENLTSIDYGQVNGGITRHFLDFLFGVNISRALMNSIQNSTKKFVKLSAGRVQTPTLSILVDREREIKKFKPKTYWVIEAKTKFFTAKFKEQKIFDKNKALKIVKECKNKNAIVKSVKITKRYRNPPVPFDLTTLQSEAYRLFGFSPRKTQSLAQNLYLGGYISYPRTSSQKLPPSIDYEKIFEGLSKNPKFERYISKLSKPFKPYEGKKTDEAHPAIHPTGVMPKNLNEDESKLYELIVHRFIAVFADKAKIANLRGVLSINDYEFIFNKQKIIKEGWMSFYPYTSVKNEEFPEIKEGDKLKIEKIIKEEKKTKPPARYTAASLIKEMEVRGLGTKSTRAEIISALYDRKYIEGRKIKVKPLGIKIINILKKYCKKITSEKLTREFEKKIKRIIKGEINKENVITEAKNEVKDILNSIEDKQKEIGEELYNAYKKSKIIGKCKCGGNLIIRYSQKYKKRFVGCSNYPACKVTYSLPKNAIILESKCKRCGLPLISYGNPRRVACLNPKCGKKIDEEKIVGKCPKCGNDLIIKSGRYGKFVGCKGFPKCKYVRSI
(37) DNA topoisomerase 1 [Methanohalobium evestigatum Z-7303]
3
MHLIIAEKHIAAKRIAAILAPKKPKKVRVSGVDTYEYEDNEDDKIVMGLSGHIVELDFPKEYNNWQKVNAEDLIDAELITKPTQVKIVAALKKLGKKASKVTIATDYDGEGELIGVEALDIIKKVNQDIQFDRVKYSAITEKEIKNAFSNPVNVDFNLADAGHSRQVIDLVWGASLTRYISLSAGRLGKMFLSVGRVQSPTLALIVDREKEREAFVPDPYWEVYATLANSNGEEFVTQHKTQRFWDKNQVNSVVDKLKDCKTAEVTSVEKSTKQDKPPSPFNTTEFISAANSVGFTASNAMRIAETLYTNGYISYPRTDNTVYPDSLDLRNLIAMFKSGQFKQYAQYLLNKSNLVPTRGKKETQDHPPIYPTSAAKKSELNEDEWKIYEMVVRRFFATFADPAKWETMKVKFDIGSEEFRAKGARLISPGWRWFYPYNSPEDKILPPLKKGEVLTVKSSKVADKETQPPGRYGQGRLVRIMEELGLGTKATRHEIISKLFSRAYVHSNPLQPTKTAFAVIDALENYAPTITKHEMTSKLEEDMEKISEGKIKEDEVLKESRDMLKSMFSELESNRDNITQSLRNGLREDKVIGTCPECESRLMVRRSKRGSRFIGCDGYPDCTFSLPLPKSGQIIVTDKVCEDHGINHIRVNIPGKRPWNLGCPHCNFIEWQKEQENNKNKQKDTTPKSITEINGIGKVTAEKLENAGVSSVEELANADAVELSKQTNLSVKKIKNWQEYVA
(55) Putative DNA topoisomerase III [Leishmania major]
3
MGRNVLMVAEKPSLAESIATILSNGSCSRRTRALPVYEYPGNFMGSPAYFKVTSTTGHVFSCDFTSQHQNWDRTDEEQLFTAPITWKDTSGKVTHHLEHEAQGCDTLVLWLDCDREGENICFEVMQVVRREIYSHHNIFRAHFSAITAEEIFQAFRNLGKPNKNISDAVTCRQELDLKVGVAFTRFQTKYFQGKYGDLDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVASRGGALLQFEWDRGRLFDETMARLILQRITKNGKVATVVNVSVSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAENLYIRGYISYPRTESTAYPSSFNLAGTLAQQKNHSMWGAYVTTLLQQGHARPKAGKDAGDHPPITPMRSASPGELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFSISGKVVEDPGFTEIMPHARVEDDRMPTGVHKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKNGIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEEYVTHIAEGRAQLDDVLSYSLDLFFAKFKFFKEHIDVFDALMGASFSAISAAGKPITRCGNCMRYLKHLDTRPQRLYCPYCEVTFALPQGGAIKPYSSFTCPIDNFELVICHIEGGKSFPICPHCYNNPPFEDMRPAIQHHDRGYGGGAATTMAPSTRHMACDECRHPTCEHSLATNYVCDCVDGSCAGSMAFVPRTAGQWKVCCNKCPMMIKLPPTAQRVYVTSEECSECAANCLDIMFPEGKSVLPNRKDRIVACIFCHPGLSPLCEEVRGRIGNFRRIGGAAAGGRGGRGGRGRGRGRGRGNREDRR
(57) DNA topoisomerase [Leishmania mexicana MHOM/GT/2001/U1103]
3
MPTWLNVAEKPSVAKEMAQSLSGGNCRTAQSQSRFNPVYEFKFEGKTMLVTSVAGHLMEDQFPPNTKNWSTYPFQGLFSAPITKYVRADLEPVKKNLEALASRAETLVLWLDCDREGENICFEVMQVVQSKRPQVQVKRAHFSALTARDLLNAVHNLKLPDKRLSDAVEARQEMDLRIGAAFTRYQTVKFRHLFAAIPGVLSFGPCQFPTLGFVVRRYWQQQGFVPEDFFTLQLQHGDTKFHSSRGSMYDQVAATLIYEDMLQAAAADGHKGRITNVQQRPSHRRPPVPLATVVMQKLAATHLRITSERCMTLAESLYQEGLISYPRTETDSYTFQESELLELVRVQTANADVAEYATAMLADIATHVRPPLRGGHDDKAHPPIHPTKAWNATQDERGRLYNLIVRHFLASLSPDAVAATTQVSAEFGGELFSAGGTTILQRGWLDIFPYERWNNTCIPNYQIGDMFQPTAVPLKKGCTSAPPHLTETHLISLMDSNGIGTDATIAQHIKTVLDREYVRREGQSLVPTTLGIALASAYESLGLASLLQPQLRAQMELAMGDIANGAATKEQVVAAAVQLYEEIFSRLMANTNAFYEELKRYLQPAVETDACAVEATVVKANFIPCGTCGGPMDLVERAGERDREVWSVRCHACNKMHRVPNGRLNTLEPVSPPHTCPLCGFLALRVANREKQTSYHVCPHCFGSPPKAWSVSAKGAASAAAPFPDVEAAAEFRCFQCTADCPLAKGLEAIGITTCIACCQHELRLRSGAKGFFLSCRGYPSCHLRVSLPAAASVKPSPSQRCPACSAVLLTFDFSGRQGVPGLNMLDAICVRCDARIKDYITVKGMPTGDPNASAAPNSAASVASTASGTYTLPSVKPSSARRSVRGGGQRGGHGADAAATNTSSGGVDTVCGCGAPAKQFVSRKEASRGKRFLTCANRQCSFFQWLD
(67) Autophagy-related protein [Komagataella pastoris GS115]
3
MRSQFKDEHPFEKRKAEAMRIRYKFADRIPVICEKVEKSDIPEVDKRKYLVPCDLTVGQFVYVIRKRIKIPSEKAIFIFIDDILPPTAALMSKVYEEHKDEDGFLYVLYSGENTFGDIPGVEEIE
(73) DNA topoisomerase [Acidithiobacillus caldus SM-1]
3
MSTVVIAEKPSMARAIQEGLGQQANRYEITNAFGHILEQAEPDAYLPGDVPKTAKGKKIWRMQDLPILPAEWKKFPKRDAKDQLAKIGALLKSADTVINAGDPDREGQLLIDEILEHFHYRGKVLRVWLKALDAENVRKAFAALESNEKYRPLKDAAEARSQSDWVVGMNLTRAVTVKSGDLFSIGRVQTPTLAIVVRRDLEIENFVPKDYFEVFAQCRHAQGAFLAKWEPSSTDGPGFDEEGRLIDKRLAEAIAQKAKGAGKVARFEAKEQKQSAPLPYSLSALQKVASSRFGMSAQQVLDTCQSLYEKKITSYPRTDCRYLPEEQLVDAPRILGKLPIPDGIRPLLNPRQKHVAWNNAKITAHNAIVPTGEPARGLSDAEAKLYDLIWKSYVALFLPDYRYRALSATIALGGESWKATGRQDIDLGWKKLFGAQALEDDEDADAARAPLPVMQTGDPVQGDGGKVEARQTKPPARFTDGSLIDAMSNIHKFVTDPQAKAKLKETSGLGTEATRASVLETLLQREYLQKKGKQLISTPKGRALIAYLEKQRLGSFADPVTTARWEDVLGMVAEGKVPMQKFTTAVTQEVAKAIEVLKSGSAMAGGGNATQQPLRAQPCPICGGDAVVRRLQSKKNRKVFFWSCSNRDAHPLLQDDNGKPGKPFEERKEDSGPPGPACPHCAGTATRTKTTSTGKTYYRCPSCQAAFWPDREDPQRLGAPWPPAENGGRRGSGATRSSSAKRSSGGDPSAPKTRSSTGGKKSASSGARGGKGRKSG
(81) DNA topoisomerase I [Olsenella uli DSM 7084]
3
MKLVVTEKNDAAQQIARLLSTVGKPKADKVYDTPVYRFTREGEEWVTIGLRGHIMAPDFPSELHYSKREGWFAVSEGGEVLPAQIPDTLLRPPYESKRKPFLKDGIDIKGWKVPSLPYLVWAPIEKLPAERGIIRALKNLAKKADSIVIGTDFDREGELIGSDALRQMRQVAPDVPVSRARYSAFTKAEIDHAFANLVDLDQDLADAGESRQYIDLIWGAVLTRYLTMARFGGFGNVRSAGRVQTPTLALVVEKERERQAFVPEDYWVLSGMLAPAGTADEDARFKATHTTARFKDQAAAQAAWSHVRDARTATVTAVEKRSRTTRPPAPFNTTSLQTAAASEGISPARTMRLAESLYMDGLISYPRVDNTVYPKSLDLRGCVRMLSQVPQYRAACRELLDAGPLHATRGKQETTDHPPIYPTAAADPGKLEGAAWKLYNLIARRFLATLSQASVSEGTKVAFDVSGEPFSASGTVLVKPGFRAIYPYGLRKDEQLPPLEVGDSCDVVSMALDAKQTEPPARYSQGRLIQEMEKRNLGTKSTRASIIQRLYDVKYLKNDPVEPSQLGMAVIDALTQYAPHITSAGMTAQLEDDMTKVAEGTDTQDEVVTHSRSLLASMMDALIEHKDDLGDAIADAVTADAKVGVCPKCGKDLVMKTSAKNRSSFVGCMGWPDCDVTYPVPKGRISPIEGEGGVCPECGAPRVKVQPFRQRAYETCINAACPTNREPDVVVGECAVCKAAGNHGDLVAHKSERTGRRFIRCTNYDVCNTSYPLPQRGEIHATGKVCEHCGAPLVEVITQRGPWRICVNMDCPGKEKKSARGTRKAGGAKAAGGKGASRG
(85) DNA topoisomerase [Desulfurococcus kamchatkensis 1221n]
3
MVSKSIRIWDLKGRILVIAEKPKAAKKIASALSPTHNAKRIGSITIYEVDSYSSSIIIASSVGHLYQLHTSLRGYPVYSYEWIPLHLTDPSKKYIREYLEVLGKLCRGVDYYVNACDYDIEGSVIGYLIIKFNGDERKAFRARFSSLTIEELRKAFNNLTRLDYEMIEAGLCRHELDWIWGINVSRALMKAVEDAVGERIILSAGRVQTPTLKYVVDKVVERNLFIPLPQYNINITVEKNGEKIRLEYTGNPVEKERDARDIVEKIRGYKYLIVSKVEKKHHILHPPPPFNLGDLQKEAARLYGFSPAETQSIAEQLYLDALISYPRTNSQKLPPTLDYRRILENISSIKSYRNLVESLISETKGVLTPVEGEKEDPAHPAIYPTGVVPGRLTEKQWAIYDLIVKRFLAVFAPPAKIVYYVVKATTPSHEYVFETKGQVIEEYGWLKYYNFHNYHAGKIPVLKEGELLNIVKATASESYTKPPKRLTKTDLLRWMESVEIGTEATRAQIIEKLFERKYLYQHQKSSGIDVSEIGFGVVEILEKFFPDLLSVELTRKFEKEMDSIRSGVKRRSEVLEEARRVLTELLGKFDRNRIEAGKQLALRLKIIQNTRKCRVSSCYREGVVNGLCSHHANAVKLVREYYGEWSRRKDITFNEYIDKLRKSKLTGKWVKEVIESELT
(101) DNA topoisomerase [Methanosarcina barkeri str. Fusaro]
3
MTIVAFAEKNKAASQIASILGEGEVERITVEGLPVYEFKWKGEEWLVMGLSGHIMNYDFPEQYNKWKEVNPGVLLEIDPQKLVTRTDYAAAVKNLAKRANKIVLACDYDREGENIGFEAKTLAEKVTNVPIERARFSSLSPKEVKKAFESLINPDYNMAMAAEARQILDLKMGAAFTRFVTLSVRERARTKDILSIGPCQTPTCGFVYEREKAIRAFQAKDFWKITAIFSAESGKEGGKEGRKEGRKEGKKERGDFEGTHRAGNIHDKEKAAEIFKRLKGTKEGLVAKKTVKETKTSPPNPLNTTEFLKRASKFLGISPELALEVAEQLYLAGFTSYPRTETNKYAEDFDFKSLVFDFARQKEYKPFAESILIAPIVPKNGEKDAHDHPPIHPIRAASRGEVSSAVNIPQAPEVYNLIARHFLANLMPAAVFEKTHLHLLVNEEPFDSSGTVLKDSGWLEAYPFENKKDKLLPFVEEGQKVGVKKLSNTKSKTSPPKKLTEAELLTLMDKNGIGTKATAPTHIETNKKRGYLETKGKTISILDTGFTLMDGLSLTVPILVKPEIRAKIEALIQEVEDGKKEFEAALYEGTTLIKEMYAQLEANKKELTSSIAGTIKDEAALEDKKNYIGTCKACGHVLRIVQTDSGRFVGCTGYPDCRNSYPLPKAGALTVLRSKECKKGGVAVLKVGNKYNWAVGIGPCFTCDLEKECYPPETVGPCPECDGSMFLINFKDTRFLGCTKRCGYTHSVPKTGKLTILDKTCETCGWKLFRLKDGDRPEEEFCINRRCTEGRKYWKKPGKGAETRIKEKASVSRPAASSVAKQAASSATSSAASPEVTQAKRKTSKVSAAGLKKSK
(112) DNA topoisomerase 1A [Leishmania infantum]
3
MLRRSVRALEKLVIVESPNKVIKVEGLLSDPKVIPDWSFNNSKLRAISTGAEKAIAMATTGHFMSLKELTWSPQSSSPASRVTSADFPSNGLLVSFSLEWELIPGRRIQDTVSHYIEEKADNLTEIIVATDPDREGELIAVHAQNLIRSMFPQLNVPFTRAYMHSITAEGIRRAMEERHEAFDYNLANAAEARHAMDRIFGFLGSSVVRYANPQMRSIGRVQTPALILIKDREDKIKSYLDSHASTFEIQAVCYFTSKHNRRFSQVVKVTPAHKGGAAPVDWSDEATVKQRCEQWALNLATHFSVSPGAKPQETVTPPPKPFTMATLIARANRQLHYSSDMVSLCLQDLFQMGYITYPRTDSTRIDESILPSIYAAVRREHGKRLLQEQDGPSKSGSRRSTAQKEAADANVEDAHEAIRPTNIDTTVEELGAVSAPMKHIYDLVRRNTMAVHMIPMKTERIVVLVACKAANGEEVEFELQGKHVVEPGWSAAFRGSKGTATPVTETDQDMEAVEDGGVVVPSISDDEFKAIMDFATQRGGGTGVKKGSMQLESAQVAENRPSPPLPFSEGGLIEQLKNNGVGRPSTYPMIVKTLLARNYITVKKGRCETTPVGRMLVDTSRATFPSIVDIGFTSAFEKKLDRIAKPGSAKEWALPPNVSDADYVLSSFISNFLNYVTEATKAHRVAITTRSLVLQQEKRVASNTPMSPTDFQANLVKEAKRVLTQVPDLVDNMKSYRTFTALQNSLNDYLRRNFPPSAAAVTPASSSGTARSYGSSSSSEKKKESHGATWKVDKKTPRRFRAKPKKPKK
(113) DNA topoisomerase III [Azospirillum brasilense Sp245]
3
MAVMATLIITEKSSQAKDLRAALGDRYGRILPAEGHLLRLAEPDEVNPDWKRWSPTLLKPDGLYPTKPDSGGNKTAKLAAIKAALKGCDQVILATDCDREGQLIGQEILEHLGFRGRVQRALFTAQDPKTIRDAFAKLKPNNELRPLYEAAVARQQADQIFNLSLTRTATKTLLAPGTRGVIGIGRVKTPTLSIVCLRELEIRNFKPEDYFEVVATATAAGGSFLMRHAPPPKDRIKDRARAEAIARAADGHGGPLSVTVEDRRQAPPKLYDLPALQKTCGQRWGWTADRTLEVAQELYDGEGKKLITYPRAEARYLSENQIADVPAIAGALTRLRGFAHLDISRPVIRRGKSGHFCDKALEGVSHHAIVPNVNVLDDLESRLNRLTDDEKRLYALICRSYLAAVMPDYEYRQTTVLMNVPVEGKPVVFRAVGRIPLKLGWKAAFGSAETDGKPDEKEEEQTLPPLTDGEPARLSEPRVEAKRTQAPPRYNEGTLVDAMQNAWRFVEDLALRDRLKEAKGIGTPATRAEIIKGLRRQNLLGADGKWLVPTPAGLQLFETLRGAAPTLVDPGTTALWEMRLDEVVVGRADFRSVIDGIADEAERLIGVLVGNQGSAVDLGVRGGPIRAGRGAGRRRSTSPRAAGAPPRPRTRKAAAAAVGVDGEAPKTPRRSRKAKAAPEVPGSIGPVADAVPPSPAAPSIGARRKAPTDKMVAFARSLADRKGVELSDTVLQDFDSCRQFLDQHAR
(117) DNA topoisomerase 1 [Thermococcus kodakarensis KOD1]
3
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVSYYEFTRDGKKVIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKQADEFVVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNMEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVEREKEIQNFEPKPYWVIKMLLEKNGGQYTAVYEKEKVWDEEEAKKIVEEAKKGPAFVEKVEVKQQNRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQKLYEKGYCLHPDSLIPTPQGVKRIKELPEKGEVFALDFDLKLSRARYRLLERDADEPMYKVTLSDRTELYLTADHPVLVYRDDQLIFVPAEELRENDQVVLFINRSEYSPRTESPTLLGFLLENATSMKDYILYDPEFGGVLRNRIKDAGLKTEILWRFRIREPTYYKYLRGKMPVPIVRFLLEEGVVSIEELREVFRGFSYSTSLTPISFEFSEEFWYLFGLVAGDGHLAKKGAITIPAKDRTEDTVKAVKEIANSLQVPFAFDEKYKMIILRSKSLTRLFELLGCPYGNKTEIFRIPGEIMAKPEWMAAFLAGYYDADGHIGTKPTGGKKSHSPQIVLTSKNRMAIYTVKQMWQLLGVGTYLWEKKDRNGNFMAYELKVYSRDAWRFYEVMKNHLRIKRKDLEHVKEVAIRKRKAYSHHYSVLNVKSWEGKIKSSNVLWKKFDMSNQTAHGRGISLDKLQRIVDYLTDTDLRRIAMGDVYVLGIRSIEKFHYRGKVYDLVVDQYHNFIANGVVVHNCSYPRTSSQKLPKNLNFRSIIQNLAKLPEYKPFAHELLGKESLKPVEGKKDDPAHPAIYPTGELPKPGELTKDEGNLYDLIVRRFLALFMEPAVRETMKVVINSNNHRFILSGARTLKEGWLKVYGKYVKFDEVILPAFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIKVTPLGMRVVEALEKNVPDIVSVELTRAFEEKMEEIMAGKADKDQVIEESKEQLIKILQVFKEKELDIGKMLLESTGTGVTTSKEAAKKTGAVKDANDEEKSDGKAGEGTTPKAERKPLVVGKCPKCGGDLVIRYNRKTGKRFVGCSNWPKCDVTYPILQRGQVIPTEKTCCNGAPVVKIREKGREYEICLDMNCKDWKKK
(124) Topoisomerase IA [Methanopyrus kandleri AV19]
3
MASSSKETMVIIAEKPSLAGTIAGFLRGSWDGRKLLGFGRYRGRRFAITSLSGHVLEWWPKDDPGFRHPDYFPDPGDFELRPIDGKERFLRAVERVVKRYAGCRADRVIVATDNDAEGELIGWEVLVWLKRQGGLDDPECARRMRFSAYTREDVLRALEGALRGERIDPSLAYSALARTIADWLYGIPLTRRLSLCNDDIVSVGRVQTPTLKLVVERERERRKAQKKRRYYWILQAETPIGELRTEEKFKDGRRARELASEIESIRVVEVRRERRSVRPPTPFNLTTLQRAAGKILRISPKRTLDLAQRLYEEGMITYPRTATNRYPSTFDHEELLRKLRNAHPDALRDFQRTGRRSEPVSGKEYDGAHPPITPTGRRKYIRGKLAWRLYDLIVRRYLATLSEDALVVKWRIVAEHPGTGTRFVMEGTEVERDGWYSVYPWEKPRESTMPDVSEGDELPANVNASRRRKPLPRRYSQSRLVAKMKKLGLGTESTRAEIVKKLFDRGYVKRAGSGVAPTKRGERLVELLEDRVPELVSVELTRRIEREMEEISELPPKRARERLERVAREIRETVRRNSKKLKSAKVV
(126) DNA topoisomerase 1 [Acidithiobacillus ferrivorans SS3]
3
MSALLIVESPKKAQHIGHILGNGWQVKATLGHIRDLPVTGEAAYVRPPDFAMRYEILDTKHKEIVSGLRAAAQSADAVYIATDPDREGEGIAWHVCQVLKIKPGEAKRVSYQEVTETAIRKALLAPRPVNMRLVAAQEARRALDRMVGWEVSPVLSNSIGAKASAGRVQSPALALVVERERAIKSFKPTAFYQVLAHMPGKDGVSGWRASWIDGTKEGEYFQDKAFAQALADALPSMPLVVSKAESKPVRRAPAPPFTTSSMQMDGARALKVGVEDIMKAAQALFDNGHITYHRTDSPNLSEEGEGLLRAALEKTGLPVVDKPRRWKAKGDAQEAHEAVRPTKPMLEEAGEDANQRALYQLIRKRALASQMPDAIYQQTSCTLNGGTFHWRDLSHPALFRAVGSVLTDPGWRALYTESEDEGEGKETEAANPVPKLSVGDKLKAERGEMVSKKTKAPPRYTESTLIKALEDHGVGRPSTYASIIKVLYKRDYMKRKGKAPALYATDLGEQVVDALRPFDFAGLEYTRLIEESLDLITEGKMPPRDLLAKSYADIQSTIATMPKGADNSQPCPVDGCGGTVSRRESKKKKGSFFWACSNRDNHNLLQDKDGTPGEPFGDKVESNTDGPACPECGKPTGRYETSNRHGFFRCAKGHGTWWDDKGAIGKLWETLPAGKGGKAKPEAAAKKSAGKPARKRTGKPAARRSTIMD
(140) DNA topoisomerase [Methylobacterium sp. 4-46]
3
MFFFEKPSAMRELQRFFRAPTTVCIAAEGHLLAAQEPAEIRPAWKAWRFEDLPIAVDEIPLCCGQSRSGASHAARIAAIRRALDGVERVIIATDPGREGSMIAWEVLEHLGYRGRVDRLRLGALDEVSIRRAFAALGRDPDSGERDYAAYQEALCRRYEDWHLGLNGTRAVSLRLRPAAFREPWRFGGVQTPTLALLADLERRIRDFVPREFFRIALPVATVSGAELTLWHAPKERIFAREEAEAIAAAARGWAGPLAVAERDVRRPPPRLFSKDTLARRCAKSFGFDPQRTASLAQDLYDRGFLSYPRTESEHLPESQSGDAPAVLAALGASLPDLAGLVPAPGAVVLRRGPRGHYVKDPGEHHAIVPLRKVPRPGEVGPEAWRLWELVAKAFLAAHLPDGIDARTTVSAEVATALGPKRFAVTGSVVRAPGWRAVYGAEAEDEEPVPGKAKREDEPSAGRLPPVAPGEAARAGEARVEGAMTEPPRRITRGELPVVMGRLIDQVEDPALKRALENPANPNEPRGLGTAATRDAVLPKLEKSGYVVLGGALPADARAGAGGNAPRRRRDTPGRADRGGGGARGRDPTITVTEAGLAFIDAVRRVFPAYGDPVGRAVFEADLAEIGRAATRAEAVSRAETFRQRTRARLDALIAAVAGLERAAVEGPAAAPAGRPPSDAMVAFATALAARKNLPLPRGVARDAAVCRRFLDAHAEKREPTAPGAPRPPTPAMLRYAESLAREAGLPDLPEEARTEFAACRAFLDAHARPAPAEARERAGPRRPGAGRPRRRPARSPRARTAGTALGEPA
(151) DNA topoisomerase [Clostridium ljungdahlii DSM 13528]
3
MKSLIIAEKPSLAMSIVKSIGSMERNNGYFENKNYIVTFAYGHLLQLYDVDDYFGREKTKWTLKELPFVPKEFKFRLRKDEGVKKQYEIIKSLIKRNDVQEIVNCGDADREGEVIVNNIIFRAFEEEHVTKPVKRLWLPEQTRQTIIQSLKDLRDDIEYKNLYDEGLARTYLDWSYGINLTRYLSIKSGSFLPVGRVLIPIVKYVYDRDEKIENFKPETYFEIGAVINKDNLHIKTKLKDRKFAANERDKAEKLLNNLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKEEKMSLDDTLKNLQKLYEAGYTTYPRTNTEYLAENEKDRIKSVIAAVKENFNADISFKDNKKIFNSKKVESHSAITPTIKIPRKEKLSEGEKKVYTAIKNRFISNFLNEETIIEETSVVIKIDDEIIQLKGNVIKSPGFLKYEKSKRENELPQFVEGEELDTKLSVDQKETQKPGRVTESELNNFLKNPFKKQEVEDLEGENDDEEYKLILEGCEIGTVATRAGIIKNAKKYEYIKELKGHLECENKGKKLIEALEKLKIDLNKEKTVEFGKQLKKVYKEEIGINEIIDKVKDELNSIVQNGNKIKIEKLYLYNNKSDSKIKIESIGKCPVCHEGEVVENKSGYGCNRWKEGCKFFVGNKIAGKEILKTHVKKLIKDSKTNVIKGFKGKSGKKFNASLVIDKEGKIVFNFENEVLGKCPCCGHDIVEGKNAFGCSNWKEGCKFTIWKNDKYLACMGKKPTKTMVCELLKNGKVKIKGLKGKDGNIFDAYLMLIKNENENKDKYPYKWKMQITK
(165) DNA topoisomerase [Thermofilum pendens Hrk 5]
3
MSYKAVIVAEKNSVARAIASFLGGSSVRRFRVERVPAYEFLWEGGKHLSIGVSGHILDFDFPEEYNKWESVDPRVLFFTNPVLVTREGAYIYVRALKTLARQTSTVILALDADVEGEAIAFEVMRIMKSVNPELEFRRAWFSAVTKSDILEAFRKLREPNENLANKAFARMVVDLTIGASFTRILTLSARRNGGVMPRGSFLSYGPCQTPVLYLVVKRELEREQFKKKKYYVLRVRFRSQEGVFTASATFEDQEKAKSALDSVKRTGVGVVVSAEFNAVEVEPPVPLNTVYLESRASLFLNLRPKETLSIAEKLYSFGYISYPRTETTIYPPTLNLRGIASMFTRWEDAGWYVAKVLAKGFTPTRGREDDKAHPPIYPTRSASREEITRRFGEKAWKVYEYVVRHFLATISENAVVERQRVVVKVGELSLQSEGRKLVYAGFYNVYKYSVPKDEPLPYVVEGEEVEVEDAKIEARTTQPPPYLSESELLALMKKYGIGTDATMQEHIHTNIERRYFVVKNKRCIPTPLGRTLALALYETVPELVLPEVRGKMEASLSKIATGERTPEEVVNEMRSEFLEYYDRLVERIDYVSKKIVEGLKMVFQDEKQQARAGSVGEERSRSTRTHRKGKK
(175) DNA topoisomerase 1 [Pyrococcus abyssi GE5]
3
MILVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDFFGYPIFDIEWVPVYIAEKNKDYAKDYIKALSVLAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPKPYWVIKLVIEKNGQKLVANYEKDKIWSEEEAKKIVTEVKKSKARVSNIEVKRQKRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTESQKLPKNLNFRLIIQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPGPGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPHKFMLSGARTVKQGWLSVYGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFERKMDLIMQGKLTKEEVIEEAKVKLTKILEEFKKRELEIGLELARIVVGDVKDEIKEEKPIVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIRDKGRDIEICLDIKCKKW
(176) DNA topoisomerase 1 [Pyrococcus abyssi GE5]
3
MILVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDFFGYPIFDIEWVPVYIAEKNKDYAKDYIKALSVLAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPKPYWVIKLVIEKNGQKLVANYEKDKIWSEEEAKKIVTEVKKSKARVSNIEVKRQKRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTESQKLPKNLNFRLIIQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPGPGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPHKFMLSGARTVKQGWLSVYGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFERKMDLIMQGKLTKEEVIEEAKVKLTKILEEFKKRELEIGLELARIVVGDVKDEIKEEKPIVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIRDKGRDIEICLDIKCKKW
(181) Reverse gyrase [Thermus sp. CCB_US3_UF1]
3
MIPTRYAAYCPNCGGEAESERLAAGLACARCQPDPQKPPLPGALAHFAAQEKALADWTRFFTAQVGAPPWPRQRAWAARVVQGRSFAMLAPTGIGKTTFGLLTASWLAREGRRSYLVFPTRLLVAQAAERLRALGAPFAAYTGKPREKEALLEGGRPIGLFTVAFLHKNHARLPRPVDFLFVDDVASLLKSARNVDRVLGLLGFAPEDVEKGLALIRLRRRHPEEAERRAERLRGKARGVLAVASATARPHSPRVHLFRELLGFEVGTPSFALRKVADLYEEAFGLSQEELWARGAEWAGRLGKGGLFFLPGDLPKEAALDLARFLRARGLRAKAYLEPEALEAFRRGEADLLVGFASWRNPLPFCPSWRTQGLRPWSEASPGGPGSRRRRSPPCEKPSWSGSPTPPSAPAWRKAPRWGSPSWGKSPSWSSPTSPATSRPRGGRAASPRRGSPRASPSSSPRTGRPSPPSCAGSATSWRRRLSPWPRRTSRPS
(191) DNA topoisomerase III, putative [Plasmodium falciparum 3D7]
3
MARLKVLNVAEKPSVASSIAEILSKGRPNKIKSCSKYNPVFTFDYKIKNDIWYMYVTSVTGHLTDQKFDDRYKNWHNTDPQELFDAEITVYVEKDKKNIENNLKKYSKECNMLILWLDCDREGEHICFEVINACRITNRKLIIHRAQFSAVTEKDIIHAINNLKEPNKNLAYSVDVRREIDLRMGSIFTRFMTIRYIELVKHETSIISYGPCQFPTLGFVVNRYLDIKNFKNEYYWSIKMKYVYNNDEINPMDDENNYDDHDDEQMDSDSDESDSYYTNNDDSNNYSDETDDYYGDEKKKKKKKKTKKKKKKKNSTKKKKKKKKNKINNNNKKNKHNNVVDFTWSRIRLFDHLAVILIYEELLKNPLCKITNVYESETRKYKPYPLNTLQMTKLVSIYFKISSKECMMLAEKLYNKGYISYPRTETNYFPDSMNLHKIINELRKNDNFGWYANKLCEEHKYQKPRKGKMNDKAHPPIHPVKNMNKSLKVEEKEWKLYEFICKHFLAVCSNDAIGYNTKVTAKIQEEQFFCKGLKIKEKNYLEIYTYEKWNDKIIPSFQVDDEFYPTSLLIEEGITQPPKYLSESNLLTLMDKFSIGTDATMHEHIENIQKRNYVIKNSKSLFIPTNLGIALVQSYKKFKDIGIDLTDPSLRAKMEKDMSLVASGVKQKNEIIRNYIDIMKYIYQEIYNRIDVLDKNIHYYLNNPDQLSYT
(199) DNA topoisomerase 1 [Pyrococcus yayanosii CH1]
3
MILIIAEKPNVARKIASALAEGRPVKKSIYGVPYYELTRDGKRLIVAPAVGHLYGLAPKRDFFGYPIFDIEWVPVYVAEKGKEYAKDYIKALSVLAKRAKEFVVATDYDTEGEVIGYTALKYACGVDPRKAKRMKFSALTKRDLLKAWYNLEPTINFGMAGAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQNFVPKPYWIIKLILEKNGRKLTATYEKDKVWDEEEAKRIVQEARKGYAIVENIDVRRLQRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQSLYEKGYCLHPDSLIPTPDGIKKIAELPKEGEVLALDFNLKLSRARYRLLERDADELMYKVTLGDRTELYLTADHPVLVCRDDKLIFVPAEELKESDQVVLVIAREGFKGRENPPTLLDFLLENARTMKDYILYDPEFGKDLRRRLKERGLKVEVMAEFNIRESTYYNYLRGKMPVPIAKFLLDKGVISREELRSVFRGFAYSTSLSPISFEFSEEFWYLYGFVVGSSYTVKNGALVISAKEREEDIVRAIREVANSLGVPFRYDAKYKLIIIRSKSLTRLFELLGCSYGNKTRTFRIQGIVVSRPGWIAAFLAGYCDADAHIRVKPTGSRKSLSPQIVLTSKNKEVIYTIKLMWQLLGVRTYLLEKKDKNGVVYELKVYPKDVPRFYEVLRSFLIVKRKDLERVIEIVAGKRAINIEETAIPLTDEDLRRIATGDVYLLKVNGIEKFRYRGKVYDLVVEDYHNFIANGVVVHNCSYPRTSSQKLPKNLNFGAILQGLSKLPEYRPFAHMLLGKEVLKPVEGKKEDPAHPAIYPTGEVPKPGELTKDEQNLYDLIVRRFLALFMEPAVRESVKVTIKAGSHRFILSGARTVKEGWLRVYGKYVKFDEVLLPGFRRGEPVRVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVVETLEKHVPEIVSVELTREFEEKMELIMNGKLTKEAVIEEAKERLLKILEEFKRKELEIGRELAKIVIGEDLVEDKREDIVVVGKCPKCGGDLVVKYNRKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCDGTPIVIIREEDGREYEICLDIRCRKGKGR
(201) DNA topoisomerase 1 [Daucus carota]
3
MKSNPGITVIKQNASNVMEKTLKEEGQSRSNSEDSDDDKPLSHKLSSGALNGNSHHIRMGSNLSCPSPYTSPKPRIIKGPEDEMLLSSELQLNAGASNAESSDSDESKPLASELEDPSSSLNKRPLIQPKNSDPSPSKKAKLSEPSAPTNRKLKTAEQEEAAADDDPSISNRNKKSTTPASKVSDKKKRPDVSASVNKVDFSKSLKVPLVLVKGRNGQPLVHNGVIFPPLYKPHGVKMLYRENPVDLTPEQEEVATMFAVMLETEYMTKPKFRENFMSDWRKILGEKHIIQNLEDCDFTPIYEWHQREKEKKKQMSTDEKKAIKEGKDETRKEKYMWAVVDGMSREKVGNFRVGTTRVVQRSWRASKDPQVKKNVYSQIDITINIGKDAPIPEPPIPGERWKEIRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGKVTREKYEKSRKLKDYIEGIRAAAYTKDFASKDSKKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVETKRPNILKFDFLGKDSIRYQNEVEVEPRVFSAIEQFRSGKEGGDDLFDQLDTSKLNAHLKELMPGLTAKVFRTYNASITLDEMVRCKLLSRETKGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMVRLNEKIEELKGLLKELQEDLTRVNKGKPPLKNSDGKPKRNLNLKRYKGKLLKLIQKLRKWSETRRLSVTKKIAQTNTKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHDVPIEKIFNKSLLAKFAWAMDVVLIFRF
(207) DNA topoisomerase (TopA) [Pyrobaculum aerophilum str. IM2]
3
MKLIVAEKRSVAQSIAKFLGRSYKSQKLYGVSVYRFNYGGGEAVAIGLSGHIMDFDFAARQNVWTWLPPEELFNATPILVLRGETLKYVKALKSLATKADEVYLALDADVEGEAIAYETALVVKMVNPRARLYRVRFNAVTYKEIVSAFQKPTYIDLKKVEKVFTRMQVDLTLGAVFTRFLTLTVRNSLNKGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKAVVEIGSSKVEMSADAKFKTKGEAEAIAATIKRGVVKIAVYKPHYVEPPEPLETVELERRASRWLGINSKKTLDIAEELYRAGYISYPRTETTIYPPTLDLKEVLEELTAGEHGPYALELLRKGFKPTRGDSDDGAHPPIYPTKGATRAEIFKVFGKAGGHAWAVYDLVVRHFLATLSPPALVEKQKIVVSFGKIELSAEGQRTIDEGYWRIYPWERQPEKPLPRVAPGEPARAVEIRVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIYTNIKRGYVKLVKGKCIPTALGISLATSLFQYAPELIEPTVRAKIEKSLNSIVKDGVSPAKLIAEIKLEFSKYYQNLKAKREEIKKALETALYSIQQQSRG
(210) DNA topoisomerase [Mycoplasma putrefaciens KS1]
3
MKVLVLLESPSKISKIQQYLQQSFPNNQYTVLASGGHIAKIADKGTWGLGIDFQTMQPEFVLEKTRSKIVSEIKKEGKKADLIVLASDPDREGEAIAWHLAKLFEDQDKEIKRATFNEITKEAVSEAFNNLREIDMNLVQAQFARQMLDKIIGYLVSKSLQKSTGLMSAGRVQTPALNILATRDEIIKKFKETLYKKIFVIDKLKTIRLVLTKDKNDRLVNTEKTYYITDQQAKEIVEELTEIYKCTDYKSTAFETRSFKPYSTAGLLQDGFSKLKLSAGQITLAAQKLYELGYITYIRTDSVKYSDHFIKDAKEYINKNYSEELFKEPVAGKKDLNSQEAHESIRPTDIWLTPEKAKLEIQDTVQQRVYSLIWWNSIKSLMKGPSGFNHRWTFKNNNYEFKQSWQEVLDLGYQAIKHSSSDENIELNEDEEVEEILKQKPRFEFNKGFELKLSKKHIKVEDAKTNPPKMFNQASLIKELKNLGIGRPSTYNPILTKLKDRQYIEYPRSKPITVTTKGYEANNFLYQHYKDFFNLNYTAEMEEKLDRIIEGDFDYQLWLSEIFASLDKKVKEEISQVTTDVLCPRCKQANLTFIKSKFNRGRGCSNFTKTGCGYREYEQPDGTWKEYVPAAKEQDSKQEKN
(212) DNA topoisomerase 1 [Mycoplasma mobile 163K]
3
MAEKVVIVESPNKVKTISKYLGKDYEVLASVGHIVKLPASGKFQLGIDLENWEPQYVLDPTKKKVVSELKKAVKNAKEVFIATDLDREGEAIGENLVHFLNLEDKYSRIRYGEITKNAILTAMENPTKLDLNLVNAQKARRMLDRIIGFRLSKLMASKLSNYPTKPTAGRVQSIGLKLIIDRENEIKAFEPEKYHTLEAKISEDVVAEYFNSNHDGDHRSWIYPKDIEKIKKEIKGPLEVKSIKTGQRTEAQITPLKQSVVFRKVQGSSNVIQSAMQRLYEGYDEGGLISYPRTDSTRLSQTFINESKKYIEKKFGKQYFSESIKGVAGDQDAHEAIRPTDVSLTPEMAVAKYGIEGAELRVYTFIYNTTLQALMKSPIRSTLRYELENNSHKFKLSSSKVIFDGYYVIDGYDRDKELPIYTEGQKIEVKQYVYSDHETKPPARYNDGTLIQMLDDLKIGRPSTFAATVSKLKERLYVKAEATNLEPSDFGFQVLEKLLISFPGTINEEYTAKVEADLDLIAENKIDYKKVLQDFWDLFSETLDTAYLTLERTILIPEQVGEECPDDGGVLIYKNSRRGDRFIACANWPECTFTRSIAKKKWFNKKKSTEEIN
(215) DNA topoisomerase (TopA) [Pyrobaculum sp. 1860]
3
MILIVAEKRSVAQAIAKYLGRSYRVQRIHGVPVYSFSYGGREAAALGLSGHIMDFDFAARQNVWTWLPPEELFNATPLLVVRREALDYVKALRALAAKADEVYLALDADVEGEAIAYEAALVVRSVNKRAPIRRVLFNAVTPREITAAFQRPTKLDLKKVEKVFTRMQIDLTLGAAFTRFLTLAVREHLERGRFLSYGPCQTPVLGMVVTRELQRRNFKPEKYYILKALVEVEGHRIEMSSDVRYKSREEGERAAASVKHGVVKTALYKPHEVEPPEPLETVELERRASRWLGINAKKTLDIAEELYRAGYISYPRTETTIYPQTLDLREILRDLAETEHGPYAEELLRRSFKPTRGDSDDGAHPPIYPTKGATKAEIMKIFGKAGAQAWAIYDFVVRHFLATLSPPALVEKQKIAAAFGGVEMYAEGQRVISEGYWRIYPWERQRDKPLPRVSPGAPARAIKVEVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIHTNVKRGYMKLAKGRCVPTDLGIALATALFQHAPELIEPTVRAKIEAALNSIVRNSTPPPKLIAEVKAEFRTYYENLKARREEIKKALLNALNTHRQ
(218) DNA topoisomerase 3 [Dictyostelium discoideum]
3
MTKRILNVAEKPSAAKEIAAILSNKRATVREGFSKYNKLWDFKYNILNFNDCEMTFTSVTGHLMEIDVVEQFKPWASCDPIQLFDAPIRKTVPSDKEPLKKTLEREIKKADILILWLDCDREGENIAFEVLEVCKNAKKKFEFYRAHFSAIIPREIDRACKNLAKPNEKDSIAVDTRMEIDLRIGAAFTRFQTLYLKKFKIISNSDNQPKTTTPANGNILNNSNNNSSGKEIISYGPCQFPTLGFVVERYFRIVNFKPEDFWHLSVVHEKMDTSSGKMIPVTFSWCRNRLFDYTAAFILYEKCLDNTEATVVDVTSKESRYRPVPLTTIELQKAASKKLRISSVQTMQYAEELYTKGLISYPRTETDSFQAGTDLKGLIGNQASNPEWGAYASRLINNNQFVYPKSGKNNDNSHPPIHPTSSATGLSGNLKKIYDFITRRFLACCSEESVFANTTVTIDIQGERFSETGTMVLKLGYLEVYPFDKRNDKLIPTYQKGERFTPKRIDLTKGTTVAPHYITEAELLTAMDNNKIGTDATMATHIQTIQDRFYVKKNESNQFVPSNLGVSLVASYELMGFEFSKPNLRAAIEADVDKISRGQKTKQEVLLSTIEKYKQLYQLANQNINCFDRSFREYYEPADPKGGEFRVLVSQFSRCGKCNGKMQYKSDQNPEAPKRILFCPQCIDTFDLPKNGDISQLVTSMGVPQNCPICQYQVLSVRNPINDKSYTICPKCRNSPPDPIHKKPFHCFQCTFNCNLATGNKQQQQQQQQQQQQTNYNRNNNNNNTNSARPITTRTTRTTTQHRTFTASNNNFNNNNRNSDRNNNNFIF
(223) DNA topoisomerase 1 [Mycoplasma mycoides subsp. mycoides SC str. PG1]
3
MKVLVLLESPSKIEKIKHYLEEGFPENQFVVLASGGHINSIADKGAWGLGIDLETMQPNFVIESSRKKIISQIKKEGKTADLIILASDPDREGEAIAYHLANLFKDHTNIKRITFNEITSEAITNAFNNLRDVNMNLVNAQISRQILDKIIGYLVSKSLQKSTGLMSAGRVQTPALNILTTRDMLIKNFKEVLYKKIFVIESKRAINLNLNKDKNNVLVNTEKTYYIDEKQAKIIVDELGEVYRCTDYKSTAYETRSFKPYSTAGLLQDGFTKLKLSTSQITLAAQKLYELGYITYIRTDSVKYSSQFINEVKDYISKNYSSDLFKDPIVGKKDQNSQEAHESIRPTNIWLTPEKASLEIEDNLLKRVYNLIWWNSIKSLMKGPSGFNHRWTFNNNGYEFKQSWQEVKDLGYQAIKHSSSDENIELTNDGEEIVQSKNDKPEYQFNDDFEINISKKFIKIEDAKTNPPKMFNQASLIKELKNLGIGRPSTYNPILTKLKDREYVEYPKSKPIVVTNKGYSANEYLYDHYLDFFNLNYTAEMEEKLDEITKGDFDYVNWLKDIYTALNFKVKKEIGEAKTEAICPRCGANLVYIKSRFNRGRGCSNFTITKCGYREYEQPDGTWKEYVKEEKTTENNTKKENKE
(236) DNA topoisomerase [Clostridium botulinum A str. ATCC 19397]
3
MSKLLLAEKPSVARNIGEALGCKTRKNGYLEGNGYIVTWAFGHLLTLYDCKDYDHKLALWSFQNFPYIPTEFKYKVKNDGKNRNVVDAGAKKQLEIIKELINRGDVEEIISATDYDREGELIALLIFNYLKANKPIYRILINEWTPTEIKKGLKDLKKNEEMISLQDAGVSRQLADWVIGINFTSIATMKYTRGKGNLLNIGRVLMPTLKIIYDREIEIKNFKVEEFYELEATFKNKKGEYKGKFFYEKKEKFPNKKIMEKLKAEIKDKSGLVTEKTIEIKKENPPSLFNLSNLQGYITSKYKGFTADKVLKVAQSLYEKKHITYPRTESTALEESIKDKAKKVLEVLKNDLPFKDEIIFNTSKKVFNNAKVESHSAIMPTYIIPKNLTPDERLVYDAIKNRFISQFMKEAQYENTEIVTTVPGENYERLFKTKGKILKCKGWLKLYKEKKKDELLPPIEKDDEVEIKSLKIISKKTKPPAHHTEKTLLKAMETCGKNTKQSEDNEEESNILYGYSIGTAATRAETINKLKYAGYITPKGKSLLITDKGTKLIETFPIRELLDTDYTGKLEKKLYDMEKGKFKKEDFLKEIFNFTVNGVNKIKNIRSNVICDTRVKKDK
(238) DNA topoisomerase 1 [Natronomonas pharaonis DSM 2160]
3
MELIVTEKDNAARRIAEILSDGSASTERRNGVNVYRWGDKRCVGLSGHVVGVDFPPEYEDWRDVQPVELVEADVVKKPTQENIVRTLKQLAGEADRATIATDYDREGELIGKEAYELIREEADIPIQRVRFSSITENEVKEAFATPDDLDFDLAAAGEARQIVDLLWGAALTRFLSLSANQLGDDFISVGRVQSPTLKLIVDREREIEAFDPDDYWELFADLAREGTTFEAQYFYREDGTEQERVWDESGAETAFETLRNAGTAVVESVRRRRRTDEPPEPFNTTQYISAANGIGLSAQRAMSVAEELYTAGYITYPRTDNTVYPDDLDPEALLSAFTDHYLFADDAEMLRSADDIEPTAGDEETTDHPPIHPTGEIPNKDDLSDDEWEVYELVVRHFFATVADAAEWEHLKVVADADGCSLKANGKRLVEPGYHEVYPYRSTSENHVPAVEEGEQLAIEDARIEEKQTQPPRRRGQSRLIEELESRGLGTKSTRHNTLQKLYDRGYIESDPPRPTKLAMAVVEAAEQFADRIVDEEMTAQLESDMQAIVDGEKDLEAVTEESRALLGRIFDELHDSREEIGEHLQESMKADRMLGPCPECGEDLLIRRSRKGSYFVGCDGFPDCRYTLPLPSQGEPTVIDEACTEHDLNHVKMLAGRSTFVHGCPQCKADEADETDDRIIGDCPDCGDNADGELAIKQLRSGSRLVGCTRYPECEYSLPLPRRGDIEVLDERCADHDLPHLRVVDNGDDPWELGCPICNYTEYREQQAASAIEDLDGVGQKTAEKLADAGIESLSDLRGADAEAVANEVQGVSEDRLREWQAEANVSASAD
(241) DNA topoisomerase 1 [Methanohalophilus mahii DSM 5219]
3
MHLIIAEKQIAARRIASILSPKKPQKKRISGIDSYEFGNDEKTIVIGLSGHIVQLDFPPAYNNWQKVEAKELVDAELIITPTHAKIVSALKKLGKKATKVTIATDYDREGELIGVEALNIVKGVNESIEYERAVYSAITPAAIKEAFENTTKIDFNLADAGHSRQVIDLVWGASLTRFISLASRRLGKQFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYVDLSKNGEIFKIRHKNTRFWEKEEANRVFRLIGNEALVSSLETSTKEDKPPTPFNTTEFIRAANSIGFTPANAMRIAESLYTNGYISYPRTDNTVYPSTIDLREQIEMFSKGHFSEYAKKLLAKKELKPTKGKKETTDHPPIFPASVAKKAQLKEDEWKLYELVVRRFFATFAENAEWETMKVRFDINEEEFRANGSRLVKPGWRWYYPYNAPEDRLIPALEEGEILPVNDKEILDKETNPPGRYGQGRLIKMMEDMALGTKATRHEIISKLYSRAYVHGNPLQPTQTAYAVVEGLENYAPTITRPDMTSSLEEDMDRIAEGNTSEENVLQQSRDMLTDVFKELEDNREKISESLREGLRKDKIIGKCPDCGCDLIVRRSRRGSRFIGCEGYPDCTFSLPLPKSGHILVTDKTCDKHSLYHIKVKGQKKRAWDLGCPYCNYLEWKEEQKKEKAATPRPEKISDIPGIGKVTEEKLNSAGISTVDELENSDANEISKTTNIPLGKIIRWQEAVAY
(245) DNA topoisomerase [Clostridium sticklandii DSM 519]
3
MSYPEKYDIKYKAWRLHDLPFLPEEYKYEIIANVQKQFDIIKEQMNRDDVTTIYVCTDSGREGEYIYRLVDMMVDAKSKEKKRVWIDSQTEDEIKKGVKNAKPLEAYDNLADSAFLRAKEDYLMGINFSRLLTLCYGRTLAKKLEKDHIVIAVGRVMTCVLGMIVNREREIRDFVKLPYYKIQALFEFEGSIDYDAEWKAVEGSKYHLSNQIYKEVGFTDKALAETFVNELKTSKEKPVIEDVKKKKETKNPPLLYNLAELQNELSKKLKQSPDQTLKIAQNLYEKKLITYPRTDARVLSTAVCKEILSNLKGLTQLDKVASLDEKDKTLPEYALEVINSNKHKGLEKTKYVNDKAITDHYAIIPTGQGLSTYNKLPGIEKEVYILIVRRFLAIFFPPAIYNQLSITTKLEDERFFSTSKVCTSEGFQVILNDEKKEDDSKQDKAEILKKLKKGQTVLVKELDIKESETTPPKRYNSGSIILAMENAGKLIEDDELREQIKGSGIGTSATRAEILSKLEKIDYISLNKKTQILTPTTLGESIYDVVAGSIPSLLRPELTASWEKGLSMIASGDIKNDEYMKKLESYIQKNTSRVLTLTKNTNVKNKASEIDKTPLGSCPLCKDGKIKENSKAYFCTNWKQSCNFTLWKNSLPELKEDISRDLVKELLASDKNSIKVHTSENKDIHIKFKESGNGELEITKSH
(254) DNA topoisomerase 1 [Methanoregula boonei 6A8]
3
MHLIVAEKNISAHRIAQILAGGTRVIEKKDAGVSTYSFGDTITVGLRGHVVEVDFEPGYENWRSEKYTPRSLIDAKTIKVPTEKRIVSLVQKLARHADRVTIATDFDTEGELIGKEAYELVRAVNKNVKIDRARFSAITAQEIGSAFANTTDLDFALAAAGEARQSIDLMWGASLTRFISLAAKRGGNNILSVGRVQSPTLSMIVDREKEIEKFVPEKYWQLGLLTEKAGEQIEARHTNGRFKDQKAAELARDRTKEPLVVTEVREGTKQDRSPSPFDTTTYIVAAARLGFSAANAMRIAEELYMNGYISYPRTDNTVYPASLDLNGVLATIRNSPFTKDVDWIISHRRAEPTRGKKSSTDHPPIYPTGVATREGIGDDAFRIYELVLRRFLATLAPDALWKTLKVNFEAGGETYTVTGGLLLEPGWHAVYPFSEAKETILPAFVTGEKLPIRKVNLEEKETLPPARYTQSKLIQRMEELGLGTKSTRHEVIARLVSRKYIEGNPLRPTLVGRVVTEALEQNADTITKPEMTQTIESHMQQIKESKRTRDDVIAESRSMLHKAFDQLEANEQVIGNDIRDRTAEELNLGRCPACGGTLAIKHMRGSTQFIGCSRYPECTFNIGLPVTQWGWAVRTDDICDKHHLHFVRLVRKGARPWDIGCPLCHHISSNAESLTEIPSMDEALLEKARSKHIYTVAEIARSEPDALAKSLDLPLEKAGKLKSEAGIVLEKLRRRSECRKFLRNHLIPRKGRSYAKIMEALGQSGVTDLASLAHATPATLQQAGIGETEARDLLTEARLTHNSQLLKGTGIPAVSLKKYLEAGVSGPEDFVSTGAEKLATLTGMSTGTINRHLALVCEYLHRPVPLAVPKAKLAKGRKELLSVKGLAATTADKLIGAGVISGDLLLAADTKKLAASTGIDEEKLRGYQALMKKKKENAIIRI
(259) DNA TOPOISOMERASE I (OMEGA-PROTEIN) [Corynebacterium glutamicum ATCC 13032]
3
MTIGILTEKASAAKNFAKALGGPSGTYNGEKYVIAAASGHLYEFVEPEEMVPPSYADKIGGYWDLAKLPWDETQFLWSREQKHGAANTIARIKKTLSSCTTIVIGSDIDPTGEGDLLAWEIIAELGLDTKKIQRMEFVDEAPASIQQAFINRRDVTSMHDEPNYLKAEFRSRFDLLSMQWTRGATKVLETTGRRAVLRNGRLKSAMVAIVGQGLDAYNDYKKIPFYQNRFIDDHGVSYVNPEEPRYKTCDEVPQLYKASAVECYEKSMKKTAPPRLLDLASLSALLSKEGFSAKNVLKTYQQMYEAQVVSYPRTEDKTITPEQFKELAPLVDKIAGLVGVNPADLTHRQPRSTHVKPKGAHGANRPGLNVPTSIAAVKTTYGVLGQRIYEVLAKSYLTMLAEDYLYEHQKGRVVDYPAFLGTANVPKSLGWKGIFDVDAEADDDAAGSDAAQQGIGTRAEPEVFEGFPQRPPHPSMTWLMKQLDKHDVGTGATRTSTYAEVTAGKSALLKETRGKVTMTDAGQLNYLLLPGTHIGDLKLTERVYADMAAVAAGEKTAEQALEPVKQWVEEDIATMTRNAKNIPQELGKKLMTTTFTPSVKHSGTWNGEQVSFKKVYCGHEFSDAECEALLRGEELTITDAMIGGQITTVTGKLAHQSFNKDGKTIKFFGFKGQVDRIASADPAVYAVGVWKVEGEKIRFKRVWGGHKFTDKEIADLLEGREIAFDAMSKAKKPYTARGSLQRGEYNGNSFVGFQLAPRD
(260) DNA TOPOISOMERASE I (OMEGA-PROTEIN) [Corynebacterium glutamicum ATCC 13032]
3
MTIGILTEKASAAKNFAKALGGPSGTYNGEKYVIAAASGHLYEFVEPEEMVPPSYADKIGGYWDLAKLPWDETQFLWSREQKHGAANTIARIKKTLSSCTTIVIGSDIDPTGEGDLLAWEIIAELGLDTKKIQRMEFVDEAPASIQQAFINRRDVTSMHDEPNYLKAEFRSRFDLLSMQWTRGATKVLETTGRRAVLRNGRLKSAMVAIVGQGLDAYNDYKKIPFYQNRFIDDHGVSYVNPEEPRYKTCDEVPQLYKASAVECYEKSMKKTAPPRLLDLASLSALLSKEGFSAKNVLKTYQQMYEAQVVSYPRTEDKTITPEQFKELAPLVDKIAGLVGVNPADLTHRQPRSTHVKPKGAHGANRPGLNVPTSIAAVKTTYGVLGQRIYEVLAKSYLTMLAEDYLYEHQKGRVVDYPAFLGTANVPKSLGWKGIFDVDAEADDDAAGSDAAQQGIGTRAEPEVFEGFPQRPPHPSMTWLMKQLDKHDVGTGATRTSTYAEVTAGKSALLKETRGKVTMTDAGQLNYLLLPGTHIGDLKLTERVYADMAAVAAGEKTAEQALEPVKQWVEEDIATMTRNAKNIPQELGKKLMTTTFTPSVKHSGTWNGEQVSFKKVYCGHEFSDAECEALLRGEELTITDAMIGGQITTVTGKLAHQSFNKDGKTIKFFGFKGQVDRIASADPAVYAVGVWKVEGEKIRFKRVWGGHKFTDKEIADLLEGREIAFDAMSKAKKPYTARGSLQRGEYNGNSFVGFQLAPRD
(262) DNA topoisomerase type IA central domain protein [Desulfovibrio salexigens DSM 2638]
3
MRLFIAEKRDVALAISQALGGPDRPTGAAFQVNGDRITWLWGHVLRLTDPEEHDERYKLWDLNTLPMKWPVTYAPESKHVDHLKKIIELAHQADELVNAGDPDPEGQRLVDEVIEFAGLLEKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAVCDQRYGYNLTRCYSTLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQIDMPSQLVEAEYIPADDAPVDEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPLPYNLLALQADAAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQALTPAFGDMAEYAAPNLKSKAFNSKKVTAHHAIIPTMNVPELGKLNEDERRIYTLIVKLYIAQFYLPAEFVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHKLQQNDSGTVESAESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDESGGIGTPATRDSHIETLFRRGFVAEKSKKVISTELGREFHDALPEFAVKPDMTALWHEKQKQIEAGELNYLQLIEEVDGSVAQEIARVKREGINIKSSAVQCPKCKTGFLKPRKGPKGKFWGCSAYPDCNATFPNKAGKPDLKAKPAKKLAASKEHKCPDCGKGLIRRPAKRKGLFWWSCSGFPECKFRCFDEKGKPKLES
(274) DNA topoisomerase type IA central domain protein [Clostridium cellulovorans 743B]
3
MSKVIIAEKPSVAKNIAEALKSNIRKDGYLEGNGYYITWAFGHLLQLYDAKDYDEKMAKWKMDNFPFIPKAFKYKVKNDSKKKDKPDAGAKKQLKIIEELINRNDVDMVISACDYDREGQIIGDIITGYLKVKKPVYRLLQNEWTADEVIKGMEKIKPNTEMKSLRDAGISRQWADWTIGINLTSVATLKYQRGKGNPLNIGRVLLPTLKIIYDRDKEIANFVPDNYFKLNATFKTSDNIEYEGAYIEKEQEKEQEKFKEREKLDEISKKMKGCTGVIVDKQTEKKKEYPPYLFNLSNLQGYITSKYKGWTSDKVLKVAQGLYEKKYITYPRTASVVLEESLADRAAKVLNTLKKSLPFQEEVKFIKNKRIFDNSKVESHSAIIPTYLEPKTLSGDEEKVYSAIKNRFIAQFMPIAESEETKIFTRIKNFDLDGIFISKGKVQIVEGWKKVEKIESKDTILPFVNINDEVDTIKTKVSAHSTKPPKRHTEKTLLRVMETCGKKFDEEQSDQMMDAILSGFSIGTPATRAETIKKLKDIGYIYTEGKNLICSELGVKLVETFPIQELFDLEYTGRLEKTLADMEKGKVEKEDFLKLIFDFTTNAINQIKGDKENVINQYEGELVKGESLGKCPCCGNDVIEGKIGFGCSNWRSGCKYVVWKEDKFLMSMGKKITKDMVMSLLADGKVAIKGLKSRKGNIFDASLSYEKNKDNDYFSWKMEFLNSQESKNRT
(281) DNA topoisomerase [Streptococcus pasteurianus ATCC 43144]
3
MNAEVIVAPAVGHLVERINPYTNFENWEMANLPALPDGFAYEPKKDTAKRFKAIKQSVKEVDAIIIGTDPDREGEAIAYRILELIPGALRKIKYRLWANSLTKKGLEQAFSKLKNPKDSINYFHEADARGDADWLVGFNLSPFVTIKMKEEGYLDKKDHSMSVGRVQTPIVSLIVRNDEAIENFKPSPYWQLKLIDPEAKVTFGNDIKYQSKAEAELMLQQLANIAIVKTVTSEEKVQEAPKLYNLTNFQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFAYLVEHIDDYQMAIHKQLETPNRSPRKNYVNDKKVLEHYAIIPTENIPDLNELSDDEKLIYQKVVFRTLLMFAPDYRYQSTSVILDNHGLEFKASGTVTKDNGWRNYLAAKKEDKELPHYQEGKNLVVDCKLLEEMTKPPTRITEQILLKKLLPKYNLGTSATRDGMIDLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVNKIKWAITKQIEKGKQI
(296) DNA topoisomerase 1 [Methanococcus voltae A3]
3
MTGLIICEKPNVAKKIADALGKPKKKSQSKVPYYEVDTKGKTYYVASAVGHLYTLIEKNKTKFGDYPTYDIDWAPASTVEGKEYVQKYINVLKKLSKDANEYYVATDWDIEGELIGYHALHHACGQDIAKRMRFSSLTKKEILKSFENTDSIDFGLVDAGDSRHKIDWFFGINISRALMQAISSAKRWKTMSTGRVQGPALAFLVEKELEIQKFVPVPYWVINANLKNENENNEVPLIATHEIDKFWDEEEANKAYGNVEGQKEAIVEEIKKTKKKIKPYPPFDLGALQREAHNAFRYSPKRTQEIAQKLYEKGYCSYPRTSSQKLPKDMEYMNEVLGKLLKSKEYGKYASEILEKNLKPIEGKKDDPAHPAIHPVDVPKEALPDDEQKLYNLIARRALAAYWDDAEREYSKITVDINGEKFKLSGSRTTHEGWHEIYYFTKFDENELPELKKGKVLPIESTEKLAKETKPPKRYTMASIIKELENRHLGTKATRADILEKLTKRGYVIEDGSLSVTELGIGVIETLKKYCPEIVEETLTRDLEDKLEKIQDHKIKKEQVIDETKVKLSQILDEFRKKEKEIGKELVEKIDSTNRSLQLIGKCKCGGDLIIIKYKGKSRFVGCSNYPDCDITYPLPQKGAIKVPNKVCEVCGLPIINYMGKDLCVNIECSSRISEEDKKILEKIENEKEEEKICPKCGGTLTIKRGAFGVFRGCSNYPECKYTENLKGESNEKEIVGKCPKCGSDLVKRKGRFGEFIGCSNYPKCRHTEKILKEGEEGKEPKKATKKTTTKKTATKKTTTKKTATKKTTTKKTATKKTTKKTPAKKKE
(298) DNA topoisomerase 1 [Archaeoglobus profundus DSM 5631]
3
MWLIVAEKDKSARRIARILFKDVKVLKKNQVNYYFSPSNKAFVLGLKGHIVEYDFPEELNNWRRTPLEALLKAKFVVKVKEKNVVKTLLELAKDAERVTIATDYDREGEFIGLTAVKLIQKVNPGVKIERVRFSALTPVDVRRAFENPTSLDLNLAKSAEVRHKVDLLWGAILTRLLSLSANRLGRDFLSVGRVQSPTLRLIVEREEQIKSFKSKYYYNAFVKVRGIYAKRKFEKEEEAKAVLESINTLKVLSFKKSVVEEKKPIPFNTTEFLKEASKFMKPDKAMAIAENLYMEGYISYPRTDNTVYPKTLNLKKLVEMFLSSDFKDHAEFVLKHGIEPSRGRKETSDHPPIHPTAVASKDELSKDEWTIYELVVKRFLATLAPKAKWEVKRVEFEQGFKAMGKKLIFAGWRLIYDYSKPEESYIPDFKVGEVLVVEEKKIKKEKTKPPSRYTTGTLIKVMESLGLGTKSTRHEIIKKLYDRKYIYGNPIRPTNLAFAVINALKETAEVVTLPDMTAKLERDMTAIAEGRIDEKDVLKESVVFLSRILKSVDRERLGSIIKEGIEKDREEEMEKNAIGSCPECGGVLLVKRANKRFIGCSNYPKCKFSRPLPQKGRLVTTSKVCEKHGVKILRIVEKDRKWEFCPLC
(322) DNA topoisomerase [Vulcanisaeta moutnovskia 768-28]
3
MIIDSLVVAEKDSVARAIAKYLAQGSISIRRIYGIKAYWFTRDNRQWVSIGLKGHIMNVDFSEELNKWHSVEPSKLFDVEPILVIRGDDLNYVRALTHLGASANTVYLALDADPEGEAIAYEAMFVIRNVNPGAVFKRVLFSAVTRNAIIEAFNSPTNLNPGLAKRVFTRMVLDLTLGAVFTRALTLSVEKIDRKALSRGSFLSYGPCQTPVLNLVVQRALERENFKPEKYYTLHIIVDADGKRIMLDHDGVFKDRQEAEKILNLVRSMAKAKVIIASYKEDFLGPPVPLDTIELERRASRFLNIRPKAALDIAEELYRHGYISYPRTETTIYPPTLSLKQVLLELTHGEHGDYAKTLLGMTIKPTRGNSNDGAHPPIYPTRGVSRQELLRYFKNERYWKIYDLVVRHFMATLSPPARIERQRIVVEVVDHRFSTDGLRMIDKGYLVIYPFESPSEKVLPRVKLGDELSIIKAWVEERETEPPPYLSESELLRLMRKYGIGTDATMQDHIHTNIIRGYFRVRNKQCIPTPLGKAVINVFSKTGGELIDPWFRSRMEKALMEITSGSLRPTDVLFTFKSEARKIYEKFMNRQNEVAMELIKALKESLSKTNRNSNRKVS
(326) DNA topoisomerase [Clostridium novyi NT]
3
MEKSLFITEKPSVAMEFVKLLNIKETKKDGFIESDNAIFTWCVGHMVTMSYPEAYDENLKIWSLKTIPFLPKEFKYELIPSVLKQFNVVKSLMLREDVKTIYVCTDSGREGEYIYRLVDMMVGVEGKDKKRVWIDSQTEEEIKRGIKEAKPLSEYDSLSDSAYLRAKEDYLLGINFSRLLTLIYGKTVSNIIGEDRVVIAVGRVMSCVLGMIVERELQIRNFEKTPFYKINGSIEIEENLGYECEFKAIEKSKYFESPKLYNDGGFKEKKDAEKLIEEIRIESKDNTAIIEKISKKKETKNPPLLFNLAELQNECSKNFKISPDETLNIIQELYEKKMLTYPRTDARVLSTAIAKEINKTISKLLRFKENEKVNNACKNILEKKLYVGLEKTKYVDDKKITDHYAIIPTGEGLESYRSLKPFQRNIYDLVVRRFLAIFYPPAIYSKITVETKIGEEYFFTTEKVCVTRGYLDILEEAQKDEKEKNLDFLNKLKKGTIVKIDELTIKEGKTSPPKRYTSGSIIIAMENAGKLIEDDELREQIKGSGIGTSATRAEILKKLERIEYIKVNNKTQIITSTTKGEVIYRVIRSSMPSLLNPKLTASWEKGLSMVVDREITPEVFMNKLENYINKNISNVVDNNRVINTNYLISGLEENNKKKIDEEKIDDVLGVCPICKKGTIVKNNKGYGCNNWKEGCKFFVAEICGVKIPVGEIKNLIKYGKTNIINGFKSKKGNEFRARLILKDNKVQLSFD
(332) Putative DNA topoisomerase III [Leishmania braziliensis]
3
MGRNVLMVAEKPSLAESIATILSSGSCSRRTRALPVYEYMGSFMGSPAYFKVTSTTGHVFSCDFTSQHQNWDRTEEEQLFTAPIVWKDTSEKVTHHLEHEAKGCDTLVLWLDCDREGENICFEVMQVVRREIYNNNSIFRAHFSAITAEEIFHAFCSLGRPNKSISDAVTCRQELDLKVGVAFTRFQTKYFQGKYGDLDASVVSYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVASRSGAVLQFDWDRGRVFDETMARLILQRITKNGKVATVTNMSVSSDTRPRPTGLNTVDLMKIASKALGIGPHYVMTIAENLYIRGYISYPRTESTAYPPSFNLVGALAQQKNHPIWGGYVTALLQGGHVHPKAGKDAGDHPPITPMRSASPGELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFSISGKVVEDPGFTEIMPHARVEDDRMPTGVNKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKNGIGTDASISTHINNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEEYVTHIAEGRARLEDVLSYSLDLFFSKFKFFKEHIDIFDGLMGASFSAISATGKPITRCGNCMRYLKHLNTRPQRLYCPYCEVTFALPQGGTVKPYSGFTCPIDNFELVVCHIDGGKSFPICPSCYNNPPFEELPSALQHHNRGNGGGATAKAAPSTRHMACDECRHPTCEHSLATNYVCDCVDGSCPGSMAFVPRTAGQWKVCCNACPMMVKLPPTAQRVYVTAEECAECAANCLDIMFPEGKSVLPNRKDRIVACIFCHPGLSPLCEEVRGRVGNFRRIGGAAAGGRGGRGGRGRGRGRGRGNREDRW
(335) DNA topoisomerase 3-beta-1 [Homo sapiens]
3
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARRPPGKPNPRRPKDKMSALAAYFV
(336) DNA topoisomerase 3-beta-1 [Homo sapiens]
3
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARRPPGKPNPRRPKDKMSALAAYFV
(337) DNA topoisomerase 3-beta-1 [Homo sapiens]
3
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARRPPGKPNPRRPKDKMSALAAYFV
(338) DNA topoisomerase 3-beta-1 [Homo sapiens]
3
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARRPPGKPNPRRPKDKMSALAAYFV
(339) DNA topoisomerase 3-beta-1 [Homo sapiens]
3
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARRPPGKPNPRRPKDKMSALAAYFV
(340) DNA topoisomerase 3-beta-1 [Homo sapiens]
3
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARRPPGKPNPRRPKDKMSALAAYFV
(343) DNA TOPOISOMERASE III [Encephalitozoon cuniculi GB-M1]
3
MRILNVAEKPSVARSISSILSKELNVRRGLHQYCPNIHFDYGNQMVFTSVLGHLLSSDFEEKSRWDEVDPEVLFTDRIVKHVQPEFVKVKENIEREALKCDMVIIWTDCDREGENIGRQIRDIVLKVKKIDVRRARFSGITLRDVESALRNLGEINEAEAEAVEVRIELDLRIGSAFTRLQTLSLGRARQGKKILSFGPCQVPTLGFVVERARERESFVPEIFWTLKFKAMHKGFKDEFTWRRGPVFDRNCVVCFFNSLSGEDARIVSREVKEKTKYRPLPLRTVELQKKCSSYFRLSGHKVMEIAEGLYNRGYISYPRTETDVFDRKFDFKHILGKLCKDSKVGEYASKLMGEFNHPRNGKNNDMAHLPIYPLKEGSGLSGSDRDIYDFVSRRFLGCIAKDAKGLETRYELKIGLEMFDLSGIRVIERNYLEVYYYDKWDDKEVGDFAVEEIVSGDLEIDEGETSAPKYLSEAELIGLMDKNGIGTDATIHEHIQKIQERGYAVKVAEEIRPLNLGTALIEGYERFGLNVGKPELRKSLEVSLKKISDGEIDGKSVVYEGVMAYRGIYAILKRNIGEFASILSRGIEADASGVTPWGSIGPKGGGKGRCRKVEGRGGIAKAIGKGEEAKGVECSCRVEAKMLKVKKGNNAGKEFYCCGKTPKSCYFFQWSTDEKSKGEEELKCFCGFEPQLLVANTESNRGRKFYKCKKAYKPCKFFQWET
(356) DNA topoisomerase 1 [Haloarcula marismortui ATCC 43049]
3
MRLIITEKDNAARRIAEILSEGGASANRRNGVNVYRWGNTRVVGLSGHVVGVDFPEEYNDWRDVEPVELIDADVTKEPTQENIVTTLKQLAREADEATIATDYDREGELIGKEAYELIREETDAPVDRVRFSSITEREVRDAFANPDDIDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGDDFISVGRVQSPTLKLIVDREREIQAFDPEDYWEIFADLQKNGSGFEAQYFYDDDGKEAERVWVEDDADDAYADLTNVDAATVTSVRRRTRTDSPPTPFNTTAFISAASSLGYSAQQAMSIAEELYTTGYITYPRTDNTVYPDDLEEDALLDEFVGAGHFGEDAEALLEQDDITATEGDEETTDHPPIHPTGEIPPKADLSDDEWEIYELVVRRFFATVAEAATWEHLRVVADAGGRSLKANGKRLVEPGYHEVYPYSSASENHVPDVEEGEELAISEVRMEAKQTQPPRRYGQSRLIQTMEDKGLGTKCLTADSDVLVRSENGDIERQTVDSLFSDGQVVLADGDTDIAVSKETPTVLSLDEATERVSEQESTLVSERPLRDDESVRTIETSRGAVTVTDDHPMYIRQDGEVTVRPASDIEAGTDLVAARRPPDTMVEPSDETVLSWETFAADCDKHSKLYGVDCGTELAAQRAARDESQTAFAERYGSYGSAVGKYERGEKDVPVWLLGELDIRPDRIHGLNYETSFENPFPLEWSPELAQVIGCLLGDGSIHRNDDENVVDVRYHNTDEALIERFARDIERLFDIEPTVTDRPGRESHHKRKYQVDVPSAVGRVLVCVLEAVTENGTPGLPDAVRPAFVGALFDDEGHISREGKAFISNTDHTLLTGVGEMLAEMGIETKLAPDQHKLHIRGRRNLEQFLDRIPIASDEKFYRGLDALDAYDVTTRKAELLEAIRQEPKTSAALAQTLGVTRGSVNKYLRELRESGHIEKQIEGSNRSLDENRTVQYVAADFEGSVYATLRGEPSSVTVEDVERREYDGPVYDLTVSENAPNFAVNGGAVVHNSTRHNSIEKLYDRGYIEGDPPRPTTLAMAVVEAAEEFADHVVSDEMTAQLEADMTAIANGEATLDDVADESREMLKRVFDELRDSREEIGEHLQESLKADKTLGPCPKCGEDMLVRRSRQGSYFVGCDGFPECRNTLPLPSTGEPQVLEDHCEEHDMHHVKMLAGRDTFVHGCPRCEAEKADESEDEVIGPCPECGSEHDGDLAIKHLRSGSRLVGCTRYPDCDYSLPLPRNGDISVTEAFCEEHDLPELVIDADSDDPWELGCPICNYEEYQARTAIEDLEDLNGIGSATAEKLGDAGVDSLAALREADPDIVATEVQGVSATQVRDWQDELEA
(362) DNA topoisomerase 1 [Pyrococcus horikoshii OT3]
3
MILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKRDVFGYPIFDIEWVPVYIAEKGKEYAREYIKALSVLAKRVREFIVACDYDTEGEVIGYTALKYACGVDPRVAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKLIFEKNGQKFTANYEKDKIWEEEEGKRIVLEVKKSIPRVSNVEIKRQKRTPPHPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFSSYPRTESQKLPRNINFRMIIQNLAKMPQYRPYAHILLGLPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEEKLYDMIVRRFLAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVKKGWLSVYGKYVKFEEVTLPEFFIGERIKVIQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGRLTKEEVIEEAKERLTKILEEFKKRELEIGIELAKIVVGEDEVKPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIREEDGREFEICLDINCKDWKAKSH
(363) DNA topoisomerase [Pyrolobus fumarii 1A]
3
MVAGGCRPPRGYGLIIAEKPKAAAKIAEALGGRYARRCTAYGVPYWVLRVDGRLFVVAPAAGHLYGLYTDERGFPVFTYRWVPLDVAEGAKHARKFLALLATLCRDASIYINACDYDVEGSVIGYMIIRNLGDVRRAYRMKFSALTPTDIRRAFRRLEPLDWPMIEAGLARHELDWLWGINVSRALMEAVKLVTGKKVVLSAGRVQSPTLVEAAKREARRRLHVPYPRFNVQVWLAGREGRLKLTIASREKLIEAKRIADRVAARGYAFVSSVAGRREYVKPPPAFNLSDLQMEAARLYGYSPAFTQEIAEQLYLDGLISYPRTNSQKLPHTLDFRGILEGLASIPAYTQLVKRLLLETRGVLRPVQGPKEDPAHPAIHPTGAVPRRKLNRAEERIYDLIVRRFLAAFSKPAVVERVTATLDFGVVRVNVSGTRVLEEGWYVYYPFSRPKDDIPRVSRGERLRVERVVVETVYTEPPEAYTKAKLVRWMEEVGIGTEATRARIVETLFDRGYLRLSGGYVTVTDLGFAVAEVLEKFFPKLTSVAMTREFERLLEDIRRGIRRRAEVVEEAKRVLSLLLEDYKKRAMRDAGLMLAKSLRLVEAERPCVICGRESVDGRLCRFHLEALEALKRGFVEWRRRLGGIGWEEYLERVASLRETGMWVRDVAKYLLETGLAP
(374) DNA topoisomerase 1 [Rubrobacter xylanophilus DSM 9941]
3
MRLIISEKANAARKIAQFLAEGPVKEGKHRSVPYHTFTWRGEECVSVGLKGHVLNPEYPEEYSNWQKVDPRELIDARILKSVSEKGVAAAVRSLAKKADRVIIATDFDREGELIGVEALSLAFEANPALMDHVERARFSALTKGEVTRAFENLVEVSRELADAGEARQDIDLIWGATLTRWVSRAVKRYGSAFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQNGGGPFVARHARGRFKEEAEARRALENLSETAVVTEVRQREATRPAPAPFNTTAFLTAAANIGVSPSRAARIAEDLYTEGYISYPRTDNTVYPESLDLREVLGFLAEVEGVGDYAGRLLGAGRLTPTRGRRQTTDHPPIYPTGRASRAELREDQWKIYQLVVRRFLATLSGPAKTLRTTLRFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEELPRLSEGDEVRVAEAELLAKETQPPGRYGQGRLIRLMEDLGLGTKATRPGIIQNLYDRGYIHGDPIVPTETGMAVAKALKDFASEIASHEMTARLEKSMDAISEGRVSKDSVVEESRELLRRVYDHLESSEEKFADIVWNGIRGDETLGPCPNCGRNLVVRRNRRNRKRFAGCEGYPECRTTFPLPQKGDIIPLGTACEACGLPEIKVLGGRRPWVTCINMDCPKKQEQRRSREETQAGGEEPSEGQRDRKRLEKSTT
(378) DNA topoisomerase [Cryptococcus neoformans var. neoformans JEC21]
3
MRVLCVAEKPSIAKSITEILSGGRWDTRNGRHQYIRNYDFLYNLAPPLGNGRGANFTVTAVLGHLTSSDFDDDHRKWGSCDPFALFDAPVITFVDQKLKTVESNLQIEARNADILMIWTDCDREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQANDLDMRQADAVATRISLDLKVGSAFTRLTTMTLQVRVPDLAEQLISYGPCQFPTLGFVVEQYTRVQAFVPETFWYIFVALEREHEDGEPSTVEFRWKRNHLFDLDLAAVLYEQCTVNPQTRVLKVESKPATKWKPLPLTTVELQQSGSRLLHMTPKRILDLAEKLYQKGIVSYPRTETDQYDPKFDFNSLIQKQTLDNQWGAYAQKSKPRNGRKNDKAHPPIHPTAHAGNLEGDERRVFELITRRFLASCSTNAEGQNTTVEISIADEIFSTTGLVVLRRNYLEVYPYDKWATHALPNFEEGEVFIPDVIDLKEGTTSRPSLLTEADLVGLMDKNGIGTDATIAEHIAKIIERGYVTEKQEARIKYLVPSTLGIGLVEGFNAIGFDRSLSKPHLRRETEHRMQLICDGVRGKREILQTTIEEYKEVFVKARREFQTVIDCVENYLHGAGEAQEALRAAARGGRGGRGTRGARGARGGRGTGGRGRGGGGVVAPRGGRDDDNDDDDDDDDDQGPPRGGVRERARGAATTRGRGTSTARGRAGAAGAGTAAGRRAGSPTFGKNGGRMEIWHARLALVNHEQPVLNRRHPKDKKPRIGTIPLLRKMAYLRVNVALMRLSPQSKQRSTVLMILISAVVVLMEVILTTEEEEGVEPQEVCASCLKGTP
(390) DNA topoisomerase 1 [Methanosaeta thermophila PT]
3
MHLIIAEKHDAAKRISEILAGKKPTVTKVSGIDTFRFDDRVVIGLSGHIVGLDYPECYNNWHKVDYRDLIRAEIVSRPTQERIVSALRKLGREADRVTIATDYDREGELIGVEALCILQEVNPSIKADRVRFSAITKSEILRAFAQPEEVDFNLAASGEARQIIDLVWGAALTRFISITSGRLGKEFLSVGRVQSPTLALIVDREKEIESFQPKPYWEIYADLEKGIRVRHSKSRIWTRDEVDRILNSLSDVARVRSISKGERRDRPPTPFDTTSFISAASSIGFTAANAMRIAESLYTNGYISYPRTDNTVYPPSIDLRSLLEMLSSGPFREDALELMKGSITPTKGKRSTTDHPPIYPTSVADKDDLKEDQWKIYELVVRRFFATLSGECVWETTSISFDIGDEVFRANGSRILDLGWRRYYPYSRAEENVLPPLREGEGLKVLSHEVLSKETQPPARFGQGRLVKLMDELGLGTKSTRHDIISKLYARAYIHGNPIRPTKTAYAVVDTLQRHAPAITKPEMTRTLENDMLKIAERKITKGEVIEESRQMLEAVFDELLAHRKEIEDSLREGLRVDRIVGKCRLCGSDLIIRRGRRGARFVGCSGYPECRFTLPLPRGGMIVVTERRCETHDMNHIRIINRGKRPWDLGCPYCNFNNWQAKKGSKTQRMPELDDISGIGPKSRERLESAGIKTLEALVSTDPASISESTGISIKKIISWQESARSIIHKGEQGGEVPGSSTC
(394) DNA topoisomerase [Gallionella capsiferriformans ES-2]
3
MKQTVKVTTNPAARNTFYLCEKPSQARTLAKVLGAEKGRDQMHFAEGVVIGHAYGHMLNLAKPETYIGTGPWCLDNLPILPKTWVWQVKDEHREHFDNLGKYLSQADLVVLATDPDEEGEVIGRQILQAHNYSGQVLRLWMSALETESLKKSLQNLRPLSETDHFYQAGRVRHEMDWLFGMNLSRAFSVLLKSKANIGRVKTRLLNEIVTNDQQAENVIQDGYETAYVMLGDTLLELIQADQPCDHIVNFKKLAGAQCGIYRNDKSCNYTDEMGVPLVTPRPLPYTLTALLADSADIGIPLDEGYKAVQKLYESGAISYPRTNSTKLPGTSSDDFAVHHAIVTMRDDLPTGMTEEATRIFELIRLNELYQRNQLITIDRTQTIEIGGEYFSSREEWKTISFDSPDRALLKNQNILANQKKLAIYKTGDEFPVKVRLTRENYGKPTYFTESSLLRMMAEKGIGTESTRVAAITNLIKEKLIDVTPQTDHEGVPCTQARTLRSTTLGRNLISRLPEVVTGQEMEAQLQQALKAMRDGHSDESAHLMRTATWLTQTIHEAA
(397) DNA topoisomerase 1 [Ferroglobus placidus DSM 10642]
3
MWLIVTEKNQTAKRIAQILFGSFQTKKKYGVNYYLNGDACVVGLKGHVVEYDFPPEYNDWKRVELKSLLNARIVRVVKEKSIVRLLEELAKKADRVTIATDYDREGELIGLEAVQIIKRVNPDVRIDRVKFSAITPEEIRKAFSSPGKINVNLAKAAETRQIIDLLWGAVLTRLISLSSGRLGRDFLSAGRVQSPTLRIIVDREKEIREFKPEPYWEITAKFERGVEAKIPRRFKDKEEAKRVYEKIGDGVVKSFEEVERVEKKPIPFNTTEFLKEASKFMPPDKAMAIAENLYINGYISYPRTDNTVYPQSLNLKKLVKMFLGSEFDKEARIALEDMKPSRGKKETKDHPPIHPTALAERKELSKDEWIIYELIVRRFLATLAPDAVWMVRKAEIISGGEKLVASGKELIKSGWRAIYIYSKAEDVFLPKLRVGERLKLLSKKLHEKKTKPPSRYSTSSLIKLMEKLNLGTKSTRHEIIRKLYSRGYVRGNPVKPTETAFSVVEALKKLYEPITLPDMTAKLEEDMNKIEEGKVDPKLVVKESVEFLRRVLESADKEELSKILSEGINKDKIVGSCPECGGNLVVKKAKGRFVACSNYPDCKFSLPLPQKGSLYVTAKTCKEHGMKFVRIKPKKGKSWEFCPYCSYLSWINR
(408) DNA topoisomerase 1 [Halorhabdus utahensis DSM 12940]
3
MRLIVTEKDNAARRIAEILSDDSASGERRNGVNVYKWGGQRVVGLSGHVVGVDFPPEYAEWRDVEPAELIDADVVTTPTRENIVATLRSLARKADEVVIATDYDREGELIGKEAYELIREETDAPVERVRFSSITEREVQKAFENPDEIDFDLAAAGEARQIVDLIWGAALTRFLSLSAKQLGNDFISVGRVQSPTLKLIVDREREIEAFDPDDYWEILADLAKDGQGFEAQYFYDDDGSEAERVWDEAAAEAAYADLSESGTATVTEVRRRTRTDDPPAPFNTTAFISAASSLGYSAQRAMSLAEELYTDGYLTYPRTDNTVYPDDLDPEELLGAFEGSYEFGDDAASLLDQDEIEPTRGETESTDHPPIHPTGELPDRDEVGADAWEIYELVVRRFFATVAEPATWAHLRVVAEAAGRSLKANGKRLLEEGYHAVYPYSSAGETFVPEVSEGDKLSIDAVELEAKQTQPPRRYGQSRLIQHMEEMGIGTKATRHNIVEKLYDRGYVEDDPPRPTKLAEAVVSAAEEYADHVVSEEMTAQLEADMTAIAEGEATLEEVTAESREMLGEIFEELRESRTEIGEFLQESLKADRTLGPCPECGEDLLVRRSRQGSYFVGCDGFPECRFTLPLPSTGEPQVTDETCEDHDLRHVKMLAGRDTFVHGCPRCKAEAADESEDEVIGHCPECGDSAAPEGQRNEGGEAAEGEGGKLAIKHLRSGSRLVGCTRYPDCDYSLPLPRRGEIVVTDERCEDHDLPHIEIHDGDDDDPWELGCPICNYEEFQARNAVENLEDLDGVGPATAEKLQDAGVADPEDLHEVDPDAVAGEVQGVSADRIREWQDELAA
(412) DNA topoisomerase [Burkholderia glumae BGR1]
3
MRLWIFEKPSMAKAVIPHLPKPHTRHEGYYETGDGYVSWLAGHVMEQVQPGDYDERWGKFPWAFEDLPIIPKDWKLKVSEDKKGQVKIIETLLKKCTSIVNGGDADREGQLLVDEVLLHFGNTKPVARIHLSAMDPTSVKKAIASLEDNATFRPLYEAGLGRQRADWLVGMNMSRAYTILAKKQNYPGVLSVGRVQSPTLALVVKRDREIDGFVPKDFWTVEAQFADPGQSALPFWSRWLPPGLSLESAEKQADVDAKGEADEDEEGDEIEGEGGTVTGQRPAWLDEQNRIINKAVADQIAANVQAAGQGTVTRYVNKPAEEQPPLPFELTGLQTALNGKYGYSAKEVLDTCQELYLQGHTTYPRSDCPYLPVSQHAEAPDVLDAIARGAPHLASLAANANVTIRSRVWNDSKVTEHHALIPTRQAPDWSTMTEIKRRTYEMIAQRYLAQLYPNCQVDKAKVEVSIAGERFAASGRVVKDPGWRVVFQGEAQATDAKKAKDATPTLPVLTEQGPVNRLAVRVDAKRTTPPPRYTEGSLLTAMKHVHRTVTDPVERKKLKALDGIGRSATRAGIIEMIIKRGFVEVKGKQLVATVVGKILVDALPAKLTDPGMTARWEALLDAIAKKQIPLHAFMAKQEEAIGELVAAARVSTLPTIPPDAMPARKPYTGSSTPRPAPDGAKKCPKCKKGYLVPRTVKNGPKAGQTFHGCNNYPECKHSVWPK
(417) DNA topoisomerase 1 [Methanosaeta concilii GP6]
3
MHLIIAEKHDAAKRIAQILSGNKPRPYRIGGVEAFKFDDKVVMGLSGHIVGVDYPPGYNNWQKVDCKELIRAEIVVRPINDKIVNALRSLGKEADRITVATDYDREGELIGVEALKIAKEANPRLREDRVRYSAIVKDEILKAFKNAGKVDYDLAASGEARQIIDLVWGAALTRYISLTSGRLGKEFLSVGRVQSPTLALIVDREKEIQSFVPKPYWEIYADLERDLRVQHARGRIWEKDEVDSIVARLGPVGIIRSIQTKPRVEKPPAPFDTTSFISAASGIGFSAANAMRIAEWLYVNGFISYPRTDNTVYPPSIDLVALTRLFLKGEFSKEAEKLLGGKMVPTRGKRSTTDHPPIYPTAPVNKSELKEEQWKIYELVVRRFFATLAESCVWDATSLKVDIGPEPFRASGARLVEPGWRYYYPYSKAEERILPALKEGERLRVLGHSVEAKETQPPARYGQGKLIKLMDELGLGTKSTRHDIISKLYARAYVQGNPMRPTNTAYAVVDTLQKYAPTITKPEMTQTLEKDMTQISEQKIKEDEVIEESRVMLTSVFDELSCNQEDIGQSLKDGLRTDKIVGTCEKCNSELIIRRGHRGSRFIGCSGYPECRFTLPLPRSGAVVVTDKVCEKHGMFHIRIINKGKRPWDLGCPHCNFLDWQAKKALELAEGKESGEGKGAKARPAKKTVRGSGAKAAKKASGPSNADGDGLARLPGIGPKTLEKLASAGIKTSGELAGANAKSLAAKTGLSEKKIAAWKSAAKALS
(423) DNA topoisomerase [Eubacterium limosum KIST612]
3
MKDLILAEKPTVAVNIAKAVGMTSRKDGYFENSQYVITFAVGHLLELYDVKDYHPEYGEKWEISHYPFVPDTFKYKIAESTRKQFKIVKDLILSDEIQEIISATDNDREGQLIADLIFRYLGVKKPIRRLITNEWTTDAIRYGLKNTVPNKSKQSLFYAGLVRQQMDWLLGINLTSVATLKLLKNGTGKDTLHIGRVILPTLKLVYDREMNVKNFKSIPIYYLNAYVKDVSGEEIIFRYIEGDEKIYKFDHDSHLVQILRLINTETAVVVGYECSEKKMNPQRLFSLPTLQGHITTKYEGWSSDKVLKIAQKLYENKLITYPRTDSVYLDETLKENMSMVLNIHKIESQYAEMLQFKDTKRIFNSEKVESHSAITITKEKPRGLSQDEHIVYEAIRNRFLEQFMPLAIDEEVEVTLAFEGKVPSEDGAFLFSAKSIVERSPGWRLIENRNATKKETLLTRMRENESVTIDRVMVNKGETKPNPLHTEETLIKAMLQCGKKYKTEDELETSILSGFTIGASSSRAAVIKKLFDSDYVIKKGKSLVTTDRGKSLIQAFPVKSLFNVETTGKMEMRLKDIEEGKADPRAYLEDVKIKTKEYVQMILETEQFVLNAGEDISIKELRCPKCGKPLHKTKSGVGCTGYEKEGNGCDFFIANPFAGKTLSNRQIALLVINKKTPIIRGFKSKKDTKFDAMLALNHQYEIKFEFQKSETDLACPLCGKPLKRNKAGMGCSGWKEGCKFMIFNPYCGKRLSDNQIEQLIKRGHTGEIKGFKKKSGNGTFSAILYLDDSDQYKVKMKFE
(441) DNA topoisomerase [Carnobacterium sp. 17-4]
3
MDQSMGHTVILAEKPSQAQAYAESFGKFSKKDGYIVLNSSNDVITWGFGHLVELASPEEYKDEWKKWNMKELPIIPEIFKFKVGQGKAKQFNVVKKLLQEADQIIIATDSDREGENIARSIINQAKAGNKEIKRLWINSLESDEIQKGFSDLRDGREFYSSYIEAQTRQISDWLVGINLSRMYTLSLQKKGINEGVFSVGRVQTPTLYMIYTRQKQIENFIPEPFFELHATVKAENGLFKAKYSKKFSTKKELQELIQKHGLLASNPGMISSVETKRISQPSPFLFSLSDLQSLVNKKYKVSPSDTLKHVQSLYEAKLVSYPRSDCRYITDSEFRYLLERIEGYQGILNHTIKEPNTSKRKRYVDGSKVQEHYAIIPTKKVPTQKALEKLPSIQREIYFTILRRSMAMFETDYKYDETTVTVDIKTVPFISKGKVILDKGWQRLEYGASKKSNKETTSELPLVKKGELVEADLNTSEGFTSPPKTYTEGTLITAMKTCGKELENEEEKEILKATEGIGTEATRANVLETLKKQNYIEIQKNNVTVTQKGEILCQAVENTLLSSPEMTAKWETYLKKIKNEDGTQQAFLDSIQKFIAHTLDSSAQVIEKRDWSTHTNSINHLSQKTIGKCPVCGQMMIDKGKFYGCSGYSNGCTFTLPKRYVGKTLSEATLKKLLDTRETQLLKGFKKKTGQTFSAALILTEDNKLLFKPYEKTEKK
(446) DNA topoisomerase [Eubacterium rectale ATCC 33656]
3
MGKSLIITEKPSVAQEFAKVLRVSGRNDGYIENGEYVISWCVGHLVGLVYPESYDMKYKKWRLEDLPFLPKEYKYDVIDSVRKQYNIVHALLQREDIDRVYWAGDAGKEGQTIEENIRNFGGVREGMEELRVWIDSQTEEEILRGIKEAKPMSAYANLGKSGIMRTIEDYAMGINFSRVMSVKYGNLLNDAAGTRSYTAIAVGRVMTCVLGMVVIREREIRNFKETPFYRVIGRFTDAGVEAEWKAVEGSRYFESPLLYKENGFKEEKDALALIEELNGKQAKIKSIVKNITKKRAPLLFNLAELQAECSKKFKISPDETLQVAQDLYEKKLTTYPRTDARVLSSAVAKEIGKNIGRLKGFEPTADFVEHIMQKRLYTNIADTQYTDDSKVTDHYAIIPTGQLTELSGLTSLQRAVFELIVRRFLSIFYPPAEYENVKLVVDVDKESFFASSKVLKSEGYLQVANPPKKKSFEESNARILGKNSETADSTDENSTANGSNDEIVVNPKVMLELADKLKAGDEIACQGYNIKFGKTSPPKRYTSGSMVLAMENAGQLIEDEELREQIKGSGIGTSATRAEIIQKLVRIGYLNLNKKTQILTPESLGEMVFEVVYMTVPALLNPKMTANWEKGLDGITRGTVDFWEYRGKLESFIRKETEKMIEQNLRPEIADRISSFAGKNARGAAARRKIGVKCPVCGGEIVTTPFGYGCANYKNDKSGCNFNIGQVAGLDIPEEQVKKLIEEGITDTIRGFKSKSGKRFDACLKLNKDEQTNKVSATFDFENVKPQKVEGIVCPDCGGDIYVSPYGYRCANYNRQTEDGCHFFVGRIADKQLSQVQFLELMANGRTETIKGFKSKSGKRFNACLVLKKEPVTEGSEKMHTVVAFDFDNVEDEIIKDVVCPLCGGQIKKTSFGYGCVNYKGDEPGSCRFSVGQIAGKTITAANLKQLLNDKKTETIRGFKSKSGKRFDACLVLKEDENKKLSVQFDFDHVEPKTVKDVVCPKCGGKIQVAPFGFVCENNRRDDPESCRFMVGKVASVKIKESVLKELLTKKKTEVISGFVSKTGMKFDAPLKLTEDGDIAFDFPEKPKPIETNVLCPKCGRPLKKTQWKYECECGFNVWHTVAKVELSEEILTELFTTGKTKKKVTGFTSKAGNVFDTCLKFENDQISFDFDNPGEEEVQSTAEVHNNADAHNNADAQSNADAYNNADTQSNTDAHNNAEVQSTADDAPDETTLNEMGIPEEFLAGFDMAADSVQADDVSEAALAAAHELFGE
(450) DNA topoisomerase 1 [Mycoplasma hyopneumoniae J]
3
MEKLIIVESPNKINTISSYLDSSYKVTACVGHITNLAKTGQFGLGIDINTWTPSYVLDKTKKKTIDEIKKLAKQAKTVIIATDADREGEAIGASLVEHLAITDKYQRIKYNEITKTAILEALENPGELNQNLINSQQTRRMLDRIIGFRLTALLKNKIKNPPKNPAAGRVQSFALSLIFDREKEIREFIPEKYFNLEVKINDENGNFFDTIYCNQQNEAKKVNWINSEEELSEIIAEIKENPYLIFKKYSKATRKDPKVIPLKQATIFKKMSQYSSASVSNALQKLYEGYGDYGLISYPRTDSTRLSQTFIEKGKEFIIKNFGPKYFTKSIKGFAGDQDAHEAIRPTNLELSPELAREKYHLGQIEFQIYQLIYQTTIQALMRSPERKITNLTFKTPIKDHIFSYSYSEFTFDGYYKATEKPSLKFKPEFSDIESLISKKFQVDKNFDNSIKSSLHQTKPPAHFRDGTLIEKLDDEKVGRPSTFAISVKKLKDHLYVDSESKSLVLSDFGKIVYENLKIISPEIIDAKFTAQVEEELDLIAQGKQDYKKYLDSMWSKIENTIEKAVEVEKVIMEARTTGEKCTECDADLVYRYNRKTNQRFIGCSSFPNCRFIKVDENAKKVYRFRKRNTKILTNK
(461) DNA topoisomerase 1 [Methanocaldococcus jannaschii DSM 2661]
3
MAEIMTALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKENKEFGFYPVFDIKWVPASVDKGKEYVNKYIKALKKLSKDADEFYIATDWDIEGELIGYHALKYCCGREKAKRMRFSSLTKKEIVRAFENPDEIDYGLVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFIPKPYWVIEALLKDNLKAIHEKEKFWNEKEAKNVYEKIKDEKSAKVVEIKKTKRKLKPLPPFDLGTLQREAYSYFKISPKETQEIAQKLYENALISYPRTSSQKLPKDRKYLEDILNIIKNHPVYGKWAERILKENLKPVEGKKEDPAHPAIHIVDIPKEELSEKEKEIYDLIARRTLAAFWDNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDEIELPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKRGLGTKATRAEIIDKLIKRGYVIDDGSLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVLDEAEKRLRKILEEFKKKEEDIGIYLIKNLDATNKKAKIVGKCPKCGGDLILIRHKKGRFVGCSNYPECDVKYSLPDKGRIKIPNKVCDACKSPILKIGDREICINPECPLKQVEVKEEDRICPKCGAKLILKKGVYGAFYGCSNYPKCKYTEPINKKEVVGKCPKCGGDLVVREGKFGKFVGCSNYPKCRYTEKLKLNEKEEK
(472) DNA topoisomerase 1 [Methanoculleus marisnigri JR1]
3
MHLIIAEKNISANRIAQILAGNEKVRATKDGSVSTYSFDTKTVVGLKGHVVEVDFEPGYTNWRSETHTPRTLIDAGIVKKPTEKKIVNLIQKLSRKADLVTIATDYDTEGELIGKEAYELVRAVNPNVRINRARFSAITPAEIRTAFENLTDLDFDLAAAGEARQTVDLMWGASLTRFISLAARRGGTNILSVGRVQSPTLAMIVEREREIESFVPQTYWMLSLATEKDGVTIEARHTAGRFTDHEAALAAEAGTKEPLVVTDVKEGQKNDRAPTPFDTTTFIVAASRLGLSAANAMRLAEDLYMNGYISYPRTDNTVYPKSLNLNAILNTLKGGVFDKDVAWVQQNRRPVPTRGKKESTDHPPIHPTGSATREALGQDRWKVYELVVRRFLATLSPDANWATTRCTFDASGEAYKATGGRLLYAGWRRIYPYSEAKENILPVLAPGERLPIKNVNLEEKETQPPARYSQSRLIQVMEELGLGTKSTRHEVIGKLVSRRYVEGNPLRPTLVGRAVIDALDNHAETITEPEMTQTLEEHMQLIKQSQRSRDDVVTESREMLHRVFDKLEAHKSEIGTEIMEQTAEEHTVGPCPDCGHDLRIRHIGVSQFIGCTGYPECRFNISLPGSTWGKAIRVEATCPEHNLSHVRLIRKGARPWDIGCPLCSHITSNVEALRMMPSMTDDLMQRLHAQHIYTVSEIAGMQPEDLAKAVDVGTKEAVELAREAEDALEVLRRRSELRKFVRKIVPPRRGRSHAKIIKNLLGQGIGDIHALSVAEPAALKKAGIPEAAGAELLEAARGLCNERALREAGVPAVSLKKYQAGGVATLDDFCYLPIPYLASKTGINPETVHKHVDLVCRHLGRPAPQKISRTVFERGRKELLEVPGLGEATVDRLYLAGIYDAATLRVADPEEVSSVTGIPKARLRDYIGHLK
(506) DNA topoisomerase 1 [Halogeometricum borinquense DSM 11551]
3
MSKGPELIITEKDNAARRIADILSGESAEADRINGVNVYKWGGKRCIGLSGHVVGVDFPPEYNDWRDVEPVELIDAPIDKHPTQENIVAALRRLARNARRVVIATDYDREGELIGKEAYELVRDVNEDVPVDRVRFSSITDREVTEAFDNPDGLDFNLAAAGEARQIVDLVWGAALTRFLSLSARQLGDDFISVGRVQGPTLKLIVDREREIEAFDPEDYWELFADLQKDSESFEAQYFYLDEDGNEAERVWDGDDAEEAYETLRNVEAATVDSVRRRTRTDDPPAPFNTTQFIRAAGSLGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPEDLDPRELLDAFTANRTFGDDAQNLLEQEEIEPTAGDNETTDHPPIHPTGELPSRSDLTEDEWDVYELVVRRFFATVAESAKWEHLRVVADAGGLSLKANGKRLVKAGYHEVYPYFNSSESFVPDVAEGESLAVTDTEIEEKQTQPPRRYGQSRLIETMEKMGIGTKATRHDVIQKLYDRNYIESDPPRPTRLARAVVEASEEFAELIVSEEMTAQLEADMQAIARGDASLDDVTAESREILEDVFEGLMESGDEVGKHLQKSLKADKTVGACPESDHDLVVRKSRRGSYFIGCDGYPDCTYTLPLPSTGKPLIMDEECDEHGLSHVKMLAGRKTFVHGCPLCKAEEADAEEDLIIGDCPECGAGAESETPQNGDGETDGEHGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGDIEVTDEECEEHDLPEIRITYDDSDREPWDLGCPICNYRAYQAEQAGGDELQSVKGIGEKTAEKLKAAGIEDVPSLKEAEPDALADLVDGVGPDTVRKWQSAAD
(507) DNA topoisomerase 1 [Halogeometricum borinquense DSM 11551]
3
MSKGPELIITEKDNAARRIADILSGESAEADRINGVNVYKWGGKRCIGLSGHVVGVDFPPEYNDWRDVEPVELIDAPIDKHPTQENIVAALRRLARNARRVVIATDYDREGELIGKEAYELVRDVNEDVPVDRVRFSSITDREVTEAFDNPDGLDFNLAAAGEARQIVDLVWGAALTRFLSLSARQLGDDFISVGRVQGPTLKLIVDREREIEAFDPEDYWELFADLQKDSESFEAQYFYLDEDGNEAERVWDGDDAEEAYETLRNVEAATVDSVRRRTRTDDPPAPFNTTQFIRAAGSLGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPEDLDPRELLDAFTANRTFGDDAQNLLEQEEIEPTAGDNETTDHPPIHPTGELPSRSDLTEDEWDVYELVVRRFFATVAESAKWEHLRVVADAGGLSLKANGKRLVKAGYHEVYPYFNSSESFVPDVAEGESLAVTDTEIEEKQTQPPRRYGQSRLIETMEKMGIGTKATRHDVIQKLYDRNYIESDPPRPTRLARAVVEASEEFAELIVSEEMTAQLEADMQAIARGDASLDDVTAESREILEDVFEGLMESGDEVGKHLQKSLKADKTVGACPESDHDLVVRKSRRGSYFIGCDGYPDCTYTLPLPSTGKPLIMDEECDEHGLSHVKMLAGRKTFVHGCPLCKAEEADAEEDLIIGDCPECGAGAESETPQNGDGETDGEHGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGDIEVTDEECEEHDLPEIRITYDDSDREPWDLGCPICNYRAYQAEQAGGDELQSVKGIGEKTAEKLKAAGIEDVPSLKEAEPDALADLVDGVGPDTVRKWQSAAD
(509) DNA topoisomerase type IA central domain protein [Pyrobaculum neutrophilum V24Sta]
3
MDLIVAEKRSVAQAIARYLGGSYKSGRLYGVPFYSFTYLGREAAALGLSGHIMDYDFTARENVWTWIPPEELFRATPVLVFRPETANYVKALRSLAKKAERVYLALDADVEGEAIAYEAALVVKLVNRRAEIYRVRFNAVTYRDVRSAFQKPTKLDLRQVEKVFTRMQIDLTLGAVFTRFLTLTVRNSLERGRFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKALVEIGGHAVEMASTERFKTRREAETAAASVKRGVVKTAVYRQHAVQPPEPLETVELERRASRWLGISSKKALDTAEELYRAGYISYPRTETTIYPSTLDLREVLKELAGGEHGPYAEELLKRGFKPTRGDSDDGAHPPIYPTRGATQGEIYKVFGKLGRQAWAIYDLVVRHFLATLSPPALVEKQRIVATFGGVELEAEGQRTIEEGYWRIYPWERQRDKPLPRVEAGEAAKAIRVEVVERETEPPPQMSESELLALMKKYGIGTDATMQDHIHTNVKRGYMRLQRGKCIPTKLGEALATALFQYAPELIEPTVRAKMEKALQDVVRGAAAPTRLIQEIKDEFERYYKALKERRQDLKTTLETALKSMSEDGSGGG
(524) DNA topoisomerase [Methanohalophilus mahii DSM 5219]
3
MTIVVFAEKNKAAAKLATILSGGNSTREHVADLPVYSFVAKGDEYKIIGLAGHITSYDFDPAYRDWKAIDPAVLLTADPIKNITKKNYERAVRQLAKQADSIVLACDYDREGENIGFEARDIALQVKKVPVKRARFSSLSANEVQKAFNNLVEPDTNLALSADTRQILDLRMGAAFTRFMTLAVREEAYTKNILSIGPCQTPTCGFVYEREKTIRDFQPEDFWKIEAVFQAGSSEFEGVHRKGNIRDVELAKKIYEKLQGTREAIVFRLNIKEKQINPPYPLNTNEFLKRASKFLDISPEKALEIAEQLYLAGFISYPRTETNRYPEDHDFKSMLKNLLRIDEYAPFAENLLKTTVSPRNGKKDGHDHPPIHPIKAVSEKQIKNAVKLDNSWKVYDLIVRHFLANLMDPALFEKTHMEVHVKDEPFDCKGSVMKSEGWKQVYPFEISKEKLLPHVQEGDKVAVNKLTNTKSQTTPPKRLTEAELLTLMDKHGIGTKATAPSHIETNKKRGYFEIKGKTISMLDTGFNLMDALGVSVPILIQPEIRAKIEGLIEDVEKGIKSFDEAISEGTVLIQKMYTRLKSGKGDIVLRIAGSIKDEKLAEDKKNHIGKCDKCGRTLSIIRTDKGRFVGCSGYPQCRNTYPLPRKGSLDVMRSRECKKGGFAVLKVGGGKYYWSVGVGPCFNCEKQKLCFPPTVIGKCPTCGCDMILIETKDSKFLGCARRCGFTCSYPQKGRVTLRDETCDECGWRIVRVKEPKKDGRHYCINRKCNQKFKNLL
(531) DNA topoisomerase [Methylobacterium extorquens AM1]
3
MPQRLFIAEKPALGRAIATALATLSGARPSAGRGFIEVGGDCVTWTIGHAYDTAEPGDYSSTWDKWSLDVLPMLPERWKLVPNAEIADQIAVLKDRIRRYDHFVNVGDAEREGQLIVDEILIENGVDPFSPKVSRVWVSSFVEKDVAAAVAGAFPNSQKKSLYEAAVARQRADWLLGMNMSRVFGLMVQQSGARGFRVSVGRVQTPTLKLVVDRDWQIENFKAVDHFAPSITFVHENGTFKAAWQFPADTKGLDPEGRLLDKAVAQALVQKIAGKTGTVESYSETPKSTSPPLPFALSTLQKACSQKFGLTAQQTLDVAQELYEKHKAITYPRSDSQHLPNSVHTDEADGILRNLAGVRELADAAGRANPKLKSPAFDDKKVTDHHGIIPTSEASASKLAAMGEIERKVFLLIARTFVAQFHPDFRYVSSAATVLCEGERFKATGTRVVDQGWKTVFGAEEADEEEEAEGTLPSMKMKDPVDAKAGSIDPKRTKPPAHFDDGTLVEAMAKIHLYVQDQEVRKRLRENDGIGTEATRASMIEKLIRAKYLERRTKGKRKILVSTDAGRQLVDLLPSDLVAPDTTAMWESFLERVKGGEFTLAQFMDRQTQFVRKRVQTAIAAGAIQVKGFSVEPLEGHGTECPHCRAGHLVTQLWPFDDEYKGRRFLRCDNWVKDRADNCRYKTPPEGYKEREKLEGEGNPCPACGKGVLKGGVVRKEGPNRGRPFLMCSEVDREKPDSCQHFEWKDETPCPSCGKGVLKRGVVRKEGPNKGRPFAMCSAVDRTNPDGCQHFSWLDEKAAKGPKIKGEGELCTVCGKGTMMRRTGRTSGKPFLSCSNWKQGASDSCDNRVFPDDGGRRPAGGASAAPAARPRGGRPSPGGGKRSFAKAR
(539) DNA topoisomerase [Sulfolobus solfataricus P2]
3
MNLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVSYWIIKDHNSSKYVIVPAAGHLFGLKGESGFPVYDADWKPLWEIDKNSYYTKRYYQLISSLSKYALGFINACDYDIEGSVIGYLIIKNLGDIKKAKRMKFSALTKSDILSAFRNISALDYDMINAGIARHKIDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVNSEIERNLFIPLPKFTVSIIVKIKDYSLNIKVNKEFEKITEAKEFLNKLINKTVKVVEVENRVRLLERPSPFNLTDLQIEAGRIYGISPYNVERIAEDLYLDGLISYPRTNSQKIPSTISIYNIIKGLENSSYRKLVDLVRKITGGKYVVKQGIKDDPAHPAIHPTGEAPKNLPNSKFKIYDLIARRFLGSVSADAKLSNTIYTLKVSDFPLEFTVSYTKILERNWLDIYHFHNVKEDKPIFLSKGDEGKIVDGKVNISLSKPTSRYTKVSLLKWMESSNLGTEATRGRIIEILVKRKYLTNNGRYIIPTKLGFYIAEILNKFFPDIVDVRMTADMESKLEMIKTGKVLESKVIKENIEKLNKFIEEYKVNKDKVGESLAKALGLIKIVKCKYCDLEQYKDGLCKYHYEAKVRLLDAVEIWKERTKYDHKKILKRISSSKSTGKYVKDIVTYMLSSE
(557) DNA topoisomerase III-like protein [Clostridium perfringens str. 13]
3
MKKVIIAEKPSVARNIADAFNIKKRKDGYFEGEEYLITWAFGHLLQLFDAKDYDENMKGWRMEKFPFIPEVFKYKIKQDSLNRNIIDKGAEKQIKIIKGLIDREDVDGIISATDFDREGQVIADEIFLYFSEKKPVYRLLLNEWTPDEVKKGMEKLKPNEEMQSLQDAGIGRQWADWIIGINLTSVTTIKYKLNDGQILNIGRVLLPTLKIIYDRDKEIENFKSSAYYKLNGTFKTSKNEEFEGTYYENNSEKFEDKKVLDEIKEKIKDKNAEIIEKQTERKKEYPPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKFITYPRTGSMALEESLVDRTRNVLEKLKVGLPYEEQIKFVQNKRVFDNSKVESHSAIVPTYMKPNNLTQDERIVYTAVKNRFLMQFMPVAEFEETKITSKINDKEVKGVFISKGKVQLIEGWRVVEKIDSKDTILPMVNEKEIVDLVDSKINKVTKKPPKKHTEKTLLRVMETCGKSFKEDAEEDSEEMMASILSGFSIGTPATRAETIKKLKDVGYITTKGKSLTCTELGRTIVEIFPVKELLDLEYTGRLEKTLSDIERGKVKKEDFLNLIKNFTIEGVKAIKNDDSMAKHFKVEAPEGVEVLGKCPNCGNPVIEGERGFGCVNWKNGCKYTIWKNDKYIASFGKQVTPQMVKLLLANGKVGFRNLKSKKGNTFAAYFIYEKDEEKGYFTWKMEFI
(591) DNA topoisomerase 1 [Chlorocebus aethiops]
3
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKLEEEEDGKLRKPKNKDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPDSVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKEQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
(592) Dna topoisomerase i (Omega-protein) [Leuconostoc kimchii IMSNU 11154]
3
MPNYLILTEKPSAAANFVKALGGKTGTFNNFTYKITNLRGHVMTLKDPEEMVAEDLKKQYKSWLVKHLPWDLNDFSWERTYIRQRNMRTGKTESTKKIIDELKKEAKTGYDAIVIATDTDPSGEGELLAWEALDAIKWRGQVLRANFMDESATGVKTAMMNLRDVSDKQQDGEYIKGESRNRWDFASMQLTRIATTAAKKQGFKVVAREGRLKSVIVWQIYAQLLAIKNYVKKPYFEVKFKDPAGHIFGRVTPDGDVIPWRFSTKNDAQKDMTQYHESAVANEKHQTRTQAPGKLLDLAGLAAILAPRGFSAKEVLSTYQKMYEAQVVSYPRTEDKTVTPEQFNELLPKIDQIAQLVQVDTRLLTHRQPRPTHVKKQGAHGANRPGENIPTSLTSLTKFGPSAQAIYDILAKNYLAMLAEDYVYDHVTADLQDYPRFKTAFNIPIEMNFKAVYDSQRAVKVEDEVEDDNSGQLGPNAQPYLYEGANKKPQTPTTKWIMAFLEKHHVGTGATRVSTLSDMSRGTKSMIKETRGKLMLTETGNVSAVMVKDTWIASPKITKRLFEMMDQVGQFEITMPKLLDSITQVVEHDMPIMLSNADELELLLGKPKPALKRPVTEKITGVFKGEEITFAKSWSGHSFTDDELTKLLNGDEISFDAKSKRGKSYTAIGKMAKQTFKGRTFYGFKLNPK
(593) DNA topoisomerase type IA central domain protein [Ruminococcus albus 7 = DSM 20455]
3
MKKLIICEKPSLAKNVRDAIAHRENVQRVGNKDLYYYESSSYVITFCFGHLLTLGEPEKYIAEGETAVLPIIPANFRLFPNDKDCARQYSLIKKLMDMPEIDGIIHCGDADREGEIIVRNVLRVARNTKPVYRLWLPEQTESTILKALSSLENDSKYDDLANAGYARTFVDWLFGYNLSRYLMQKANVRKGWGVGRVIIPIVDTVYQRELEIRNFVSTPYFQLHGETEKDGIKVTITDKEKFDTQEQAQLRLTELSSGVYRVGSIDTKKAVVTPPKMFSLDTLQGKLSKDLGMTLDKSMPIIQSLYDKKFITYPRADTEYFAEEEKADVFAVADKMNAVYSLDLEHKVSKKIFDSSKVESHSAIRPTLNFPTNESGLSDDEQKVYNTIVKRFCAVFAPPCTVNRTVIVFTDGTHEFKIKGDTPLTPGFRRYEPPKKTNDNDEDNKMLPSFSPGELVSFSWVIDNKMTKAPPRYTIDSLNAYLKAPFAKSSSAQDNDDSPADDSELYEAVKKGMEIGTVATRTGLITKCVKTYKYLDIKQGKYYCTEKGEAFIGYLHQLNIDLFTERNIEFNMMIKSVELGKETMQHSIDKTADELRRIIAQDVTVCSAQKFTDSNSLGKCPFCGSDVLDGTKNFYCSAYKSGCKFVIFKNTYCHFSFVKDGKEINYTKPMSLTKSNCKALLSSGSTTVSIEEKNGKGKYKIGVTFKPDNKHEFVGIERIREKKKEG
(601) DNA topoisomerase 3 [Caenorhabditis elegans]
3
MKRALFVAEKNDVAKGVAAILSNGTANRREGRSKFNKIYTLNTELFGQQTAISVTSVSGHMMNFQFHENMSNWQTASMVELFRAPVRHVVTPEMKLIEQTLREQAQRHDILVVWTDCDREGEAIGAEIVKVCRDSNRRLDIFRARFSEITKAAITRAARNLIRLDEKTVAAVDCRSELDLRIGSAFTRLQTLHLRNRFRDLLGQNDTSQVISYGSCQFPTLGFVTDRYKMIENFVSEPFWKLIVEHTRESHKVEFLWDRNRLFDRDTVDILHDECKETKEAHVEKVAKKPKSKWRPQALDTVELEKLGISKLRMSAKQTMQVAEKLYSKGFISYPRTETNKFPAGLNLTPLVQQQTQSNIWGDFANEVLQNGVNPRNGRKSDEAHPPIHPLKFTEKHQLQGDDWKVYELVVRHFLACVSQDAQGEETMVNLTVGTEKFHASGLRIRDMGYLKVYVYEKWGNRLLPTYTEGERFTDFELKIGDGKTQAPDFLTEADLISLMDKYGIGTDATHAEHIEKIKTREYIGVRPDGKLIPSFLGLALVDGYDDMGFAMSKPDLRANLEIGLKEICDGRRQKQEVLDEQIGKYRAIFVESERKIGVLSQSLQRYLDKNNQAGGGPGGPGGGGGPPRGPGGGGGGGPTGPPAPPKPPAKPRGRPPRKSISPAVKNGHDDPENDTIVTLSEVFGSMSNPKPARKPRAPRKSAAPKEQEEEEEVFCQCPEPMRAVTKVVQKEGPNKGKKFYTCSLPYTSSEKCNFFKWA
(602) DNA topoisomerase 3 [Caenorhabditis elegans]
3
MKRALFVAEKNDVAKGVAAILSNGTANRREGRSKFNKIYTLNTELFGQQTAISVTSVSGHMMNFQFHENMSNWQTASMVELFRAPVRHVVTPEMKLIEQTLREQAQRHDILVVWTDCDREGEAIGAEIVKVCRDSNRRLDIFRARFSEITKAAITRAARNLIRLDEKTVAAVDCRSELDLRIGSAFTRLQTLHLRNRFRDLLGQNDTSQVISYGSCQFPTLGFVTDRYKMIENFVSEPFWKLIVEHTRESHKVEFLWDRNRLFDRDTVDILHDECKETKEAHVEKVAKKPKSKWRPQALDTVELEKLGISKLRMSAKQTMQVAEKLYSKGFISYPRTETNKFPAGLNLTPLVQQQTQSNIWGDFANEVLQNGVNPRNGRKSDEAHPPIHPLKFTEKHQLQGDDWKVYELVVRHFLACVSQDAQGEETMVNLTVGTEKFHASGLRIRDMGYLKVYVYEKWGNRLLPTYTEGERFTDFELKIGDGKTQAPDFLTEADLISLMDKYGIGTDATHAEHIEKIKTREYIGVRPDGKLIPSFLGLALVDGYDDMGFAMSKPDLRANLEIGLKEICDGRRQKQEVLDEQIGKYRAIFVESERKIGVLSQSLQRYLDKNNQAGGGPGGPGGGGGPPRGPGGGGGGGPTGPPAPPKPPAKPRGRPPRKSISPAVKNGHDDPENDTIVTLSEVFGSMSNPKPARKPRAPRKSAAPKEQEEEEEVFCQCPEPMRAVTKVVQKEGPNKGKKFYTCSLPYTSSEKCNFFKWA
(617) DNA topoisomerase 1 [Methanobacterium paludis]
3
MHEVIICEKPKAAEKISSALSKGAAKKHYKKVPYYEFEENGKKTTVLTAVGHLYSLAPKDKKQDKLFDVEWVPLYEKDKKKKYVKNYIDAIKKLSKDADTFVHACDYDIEGTLIGYNALKYACGDESLKNVMRMKFSTLTDEDILKAYKKPMELDFKQVDSGIARHVLDFFFGVNMSKHLTDSVMKATKRYIQLSAGRVQTPTLSILVDREKEIKEFIPVPYWLIKADLDVTGVKEGITADHKKGKILEKKDADAILVECKGKDAVITEVNLRKTTKTPPFPFDLGSLQSEAYGVFGFSPRKTQQIAQNLYTEGYTSYPRTSSQKLPKSIGYDKILKKLSYSSAFGNHVAQLKKPYKPNEGKKTDEAHPAIHPTGVLPKELSTDYRKLYELIVYRFISVFGENATLETMKTTLTIGKEEFNFSRKRMSKMGWMGHYPFRKIEEDYFPTMNKGETLNVKEVRAEDKETKPPARYNQASLIRELEKRGLGTKSTRANIIDILFSRKYVEGKKITVNKLGEQLIDTLRKYSKKITSEELTREFETKLEGIMEGKDKKDKIIDEARVEVSSILDDIEKNKLKIGEELYKSYRESRVVGKCKCGKNLILIDSPRGSTFVGCSGYPECKSTYSMPRGATVLKTTCEECGLPMISFGKPRQRACLDPKCGKDGREPTNEVVGKCPDCGSDLIKRSGRYGEFIGCSGFPKCRFTKSIDDDGGKTAAKTTGAPKKTVAKKAATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKNAKKTK
(625) DNA topoisomerase [Thermosphaera aggregans DSM 11486]
3
MNNIYSTIGRGPGFTSIWDLKGKVLVIAEKPKAARKIAEALSQRYFVRNINDVTYFEIRDGPRQIIVASSVGHLYGLTTQEEGYPVYTYQWVPLYVVEKKKAHSYNYLEALRKLCTTSNYFVNACDYDIEGSVIGYLIIKFNGDPGRAYRAKFSSLTLSELREAFRRLTQLDYEMIEAGLCRHELDWLWGINVSRAIMRTVESFSKKKIILSAGRVQTPTLKYVSDIEKERNLFIPIPVYSVVPTIVKDGVKITLELINSPIRTKKDAYALAERIRREGFLTVESYVEHTTSVAPPPPFNLGDLQEEAARIYGYSPSKTQSIAEQLYLDALISYPRTNSQKLPSGLDFKSLLTKISQISNYSALVSDLLKETKGYLKPVEGDKEDPAHPAIYPTGVRPVKLSSEQWAVYDLIVRRFLAAFAGNAIIYRSTAKFALPGENIVFQATGQGIEDLGWYKYYPFHKPSVKVLPRFRNGERVEVVEVSVKTAYTRPPQRISKIGMLRWMESVEIGTEATRATIIEKLFERKYLVNTSRGVAVTDLGLGIVETLEIFFPELVKVELTRHFEKLMNDIKKGVVKREQVITEARNTLDMLIKKFNEKKETVGQILSSRLGIYTPPNKCAICNREEFSNGLCTYHYKANEQINKVYEEWKEREGVSFKEYLERIKKLKSTGKWVIEVIEHFYGGK
(630) DNA topoisomerase [Streptobacillus moniliformis DSM 12112]
3
MKLIIAEKGSLGRNIAQAIGIIKKNEGYIECKNDFVVTNAIGHLLELKQPKDYEENVGKKWREYTLPFIPNNFVYEVKDDVGVKKQLNVIKGLMKKADLIINCGDADREGQIIVDNLLKFNVNKAPVKRLWLPEQTEETIRKELNNLKDNSDYYNLQQEGYARAYMDYLLGHNLTIMFTNLSGKMLNAGRVLVPIVKYIYDRDKEIKNFIVEKYYSVENENIVKLISSNKFKTIEEAKIYSNKLNSKKAKVIGIDSKEVKKQSKKLFSLSTLQSELSKKYKINFANSLKIIQELYEKGYLTYPRTNTEYLSENEKGKVNDILGVLNNEDLEFKDSKKVFDDSKIESHSAITITTKIPGELSVEQDKVYKMVYNRFLSNFVKEDCIVSETTMIIKVDEEEFKLKGFVVKQLGFMKYEPKEYKDKLPGLNLNDEFDIEFRSVEKETTPPSKVNESELSKFLKNPFKKEKNATEEEIYKDILEGIEIGTEATRTGIIDKCVKIGYLTLDNGVFDVTELGIFFINKLIEYDINFFKEKSVEFSKLQKKVYKNEMKLEEVIKKVEYELKAIVERTKDVKMPNIERKIEDIKGVVEINTKNGKCYKGLFNNEEVWLYPIMKYFNNELKITKSIAEKLCKGNYVEFELDYKGKKYMQKLRIVRNGKYINFKSKN
(636) DNA topoisomerase 1 [Staphylothermus marinus F1]
3
MGDKAKKSIIDYILSYSEKQKKKPVKTKEKTSSKKAIEKTEIQITHNIWDLIGKIVVIAEKPKAANKIALALSRNPIRKSMYGIPYYLIKNRHSSIIVASAAGHLYGLHTDQYGYPVFKYEWKPLYQIDPKAKHTEKFIMVLSKLCSNADYYVNACDYDIEGSVIGYLIIYFHGDLEKSLRAKFSSLTIEELRESFRKLTSLDWEMIEAGLCRHELDWIWGINISRALMSSVKIASGKRVILSAGRVQTPTLRYVVEKDIERRLFIPLPQYSLSINIFKNNYEIHVEYKGKSVETKKNAKEIIDEIKRTGYLIVKKYEEKIYTLNPPPAFNLGDLQEEAARIYGFSPYKTQSIAEKLYLDALISYPRTNSQKLPPTLNYKAIMNKLSRINNYKELVSNLLVETKGVLKPVQGSKDDPAHPAIYPTGVKPKDLGKDEWKIYDLIVRRFLAAFASKARISHRIVYLEYPKDPSMVFQASGQKILDLGWLRYYPFSKPEERFLPKFQYGEKVKIVKASIRKTYTKPPEKINKIKILRWMENVGIGTEATRARIIEILFSRYYLRSVGGRVEATDLGLGIIEVLMEYFPEITSVSLTRHFEEEMEKIRLGVKRREEVVKDAKNTLIKLIVSFDKKKYQIGKTLSYRLGYITPINKCILCNREAYKNNLCKYHYRALNTVIKTYDEWKRREGVDWNKYLSSIKKLKSTGKWIVEVIQNFEKIKYSPSE
(637) DNA topoisomerase 1 [Halopiger xanaduensis SH-6]
3
MELIITEKDNAARRIADILSGGTYDSSRENGVNVYEWGGKRCVGLSGHVVGVDFPDEYSDWRDVEPAELIDADVEKTATKENIVATLRIFARKATSVTIATDYDREGELIGKEAYEIVRDVNEDVPIRRVRFSSITENEVQEAFENPDDLDFDLAAAGEARQIIDLVWGAALTRFLSLSAGQLGNDFISVGRVQSPTLKLIVDREREIQAFDPEDYWELFADLAKDDTTFESQYFYRDEDDNEAERVWEEAAAEEVYDTLSQRDSATVVDVNRRTRTDAPPTPFNTTQFIRAAGALGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPEELLDDFVGHPTLGESAEDLLEADEIQPTEGDEETTDHPPIHPTGEIPARGDVSDDEWEIFELVVRRFYATVAEAAVWEHLKVVSEVEDYRLKANGKRLVEPGYHDVYPYFSTAENYVPDVEEGEELALSDVELEEKQTQPPRRYGQSRLIETMEDMGIGTKSTRHNTLEKLYDRGYIESDPPRPTKLAMAVVDAAENYADRVVSEEMTAQLEADMDAIASGEAGLEDVTDESREMLEEIFANLAESREEIGDHLRKSLKDDKRLGPCPECGEDLLVRNSRHGSYFIGCDGYPDCENTLPLPSTGKPLILESECEEHGLNEVKMLAGRQTFVHGCPLCKAEDAGEGPVLGECPDCGEEHDGDLAVKTLQSGSRLVGCTRYPDCEYSLPLPRRGEIEVTDERCDEHDLPELVVHSGDEPWELGCPICNYQEFQARESDSGSDLEALDGLGAKTVEKLADAGIESIDDLTEADPDAVAEDVDGVSADRIRNWQAEA
(650) DNA topoisomerase 1 [Mycoplasma leachii 99/014/6]
3
MKVLVLLESPSKIEKIKHYLEENFPENEFVVLASGGHINSIADKGTWGLGIDLETMQPNFVIESSRKKIISQIKKEGKTADLIILASDPDREGEAIAYHLANLFKDHTNIKRITFNEITSEAITNAFNNLRDIDMNLVNAQISRQILDKIIGYLVSKSLQKSTGLMSAGRVQTPALNILTTRDTLIKNFKEVLYKKIFVIESKRAINLNLNKDKNNVLVNTEKTYYIDENQAKAIVDELGEIYRCTDYKSTAYETRSFKPYSTAGLLQDGFTKLKLSTSQITLTAQKLYELGYITYIRTDSVKYSSQFIGEVKDYISKNYSSDLFKDPIVGKKDQNSQEAHESIRPTNIWLTPEKASLEIEDNLLKRVYNLIWWNSIKSLMKGPSGFNHRWTFNNNGYEFKQSWQEVKDLGYQAIKHSSSDENIELTDDGEEIVQSKNDKPEYQFNDDFEISISKKFIKIESAKTNPPKMFNQASLIKELKNLGIGRPSTYNPILTKLKDREYVEYPKSKPIVVTNKGYSANEYLYDHYLDFFNLNYTAEMEEKLDEITRGDFDYVNWLKNIYNALNFKVKKEIGEAKTEAICPRCGANLVYIKSRFNRGRGCSNFTITKCGYREYEQPDGTWKEYIKEEKNIDDNTKKENKE
(653) DNA topoisomerase 1 [Methanothermobacter thermautotrophicus str. Delta H]
3
MRSLSGKMHEVIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHLYSLRPRQSNEEHFFDLEWAPIHEIDKKKGYVKDYLNVIRKFAAGADRYIHACDYDIEGTLIGFNALKYGCGEEALRKTSRMKFSTLTREEIQRAYKNPIEVDYGQVDSGAARHILDFIFGVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRDFKPVPYWIIRAELGEGIIAESKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKPPVPFDLGTLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYEKILKNLAKNPRFGVHIERLRGPLKPHEGKKEDDAHPAIHPTGLLPSELSKDEKKVYDLIVHRFISVFGEDAILQTMKVELEIGEEEFSFSRKRVSKAGWMESYPYTKMEDEEFPEISGGDSLAVRSVSADERETKPPARYNEASLIRELERRGLGTKSTRADIIAKLYDRKYIEGKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELEDIMRGKISKDRVIDEAITEVRSILSDIEENLRDIGKELYRAYQDSRVVGECPACGGKLVIKYSPRNRSTFVGCSSYPDCRTVYSLPRGASVLKSLCEKCGLPMISYGRPRQRACLDPKCGKKKSEVEEVVGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCSVDEVPEG
(660) DNA topoisomerase 1 [Haloarcula hispanica ATCC 33960]
3
MRLIITEKDNAARRIAEILSEGSASASRQNGVNVYRWGNTRVVGLSGHVVGVDFPEEYNDWRDVEPVELIDADVTKEPTQENIVTTLKQLAREADEATIATDYDREGELIGKEAYELIREETDAPVDRVRFSSITEREVRDAFANPDDIDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGDDFISVGRVQSPTLKLIVDREREIQAFDPEDYWEIFADLQKNGSGFEAQYFYDDDGKEAERVWVEDDADDAYADLTGVNAATVTSVRRRTRTDSPPTPFNTTAFISAASSLGYSAQQAMSIAEELYTTGYITYPRTDNTVYPDDLEEDALLDEFVGAGHFGEDAEKLLEQDDITATEGDEETTDHPPIHPTGEIPPKVDLSDDEWEIYELVVRRFFATVAEAATWEHLRVVADAGGRSLKANGKRLVEPGYHEVYPYSSASENHVPDVEEGEELAISEVRMEAKQTQPPRRYGQSRLIQTMEDKGLGTKSTRHNSIEKLYDRGYIEGDPPRPTTLAMAVVEAAEEFADHVVSDEMTAQLEADMTAIANGEATLDDVADESREMLKRVFDELRDSREEIGEHLQESLKADKTLGPCPKCGEDMLVRRSRQGSYFVGCDGFPECRNTLPLPSTGEPQVLEEHCEEHDMYHVKMLAGRDTFVHGCPRCEAEKADESEDEVIGPCPECGVAPAEQRGDGGEAAEAEGGELAIKHLRSGSRLVGCTRYPDCDYSLPLPRNGDISVTEAYCEEHDLPELVIDADSDDPWELGCPICNYEEYQARTAVEDLEDLNGIGSATAEKLGDAGVDSLAALREADPDIVATEVQGVSATQVREWQDELEA
(663) DNA topoisomerase I [Methanocella arvoryzae MRE50]
3
MHLIITEKHDAASKIAAILFKDRTPERINGVPAYRSKAADALVIGLAGHILELDFPEAYQKWSAFPPRELIRAQVVTYPSKKDLVGALATLATKVTRVTIATDYDREGEMIGVEAYNIIKKISSPTFDRVRYSSFTKEEITKAFASPTAVDFDLAAAGECRQEIDLVWGAALTRFVSIAGNKFGKDFLSVGRVQTPLLALIVDREKEIQAFTSKPYWEIVATLLKEDRSFTASHKRGRFDKKEEAAAIHKKLGKTAVVKDVKADRKKEQPPIPFNTTEFVKAASALGFTAASAMQIAEALYINGWISYPRTDNTVYPDTLNLKDLLGIFKTSPDFAKSALELLAMPSITPTRGKVETKDHPPIYPVACAMRKDLDDRQWKLYELVVRRYFATLSPACEWETIKAEIDISGEPFAANGKQLAVPGWRKHYPYGLQKDELLPPLKAGDPLLVRKADLLEKKTEPPKRYGQGKLVQMMEDLGLGTKATRHEALAKLYQRGFIEGNPPQPTATGISLIDALKAYASAITSNAMTSKLERDMDAIAASQLKKAAVAKESREMLDKVFDQLEKNRLEIGRILRSGFAADSDIGPCPLCGSALVVRERKSDKNKFIACSGFPNCRNTYNVPPGTLKFDKTVCEKHRLHHVKVTPPSTKGPDGKAVRGKAYDFGCPACRKENPSVMPPCVKTCKPDLRAMIPHGRESGELVTTEAHRVTGLPQRHRDAQRFTEIFTIIIMMLTLRLQLLFFCPSRYPITSPVTIPVPLQQGSGRG
(675) Topoisomerase IA [Cryptobacterium curtum DSM 15641]
3
MKLIVTEKNDAAEKISELLGAGRPKKDKVYSTPVYRFTHQGEEWVTIGLRGHILEVDFAQRLVWSKRAGWRGVGATGEALDAEVPADLPTPPFKKKKPFSEDGVDLKAWKMEALPYLTYAPIEKLPKEKDIIRSLKNLAKKADSVVIATDFDREGELIGSDALSQIHEANPLLPVSRARYSAFTKQEITTAFDNLVQLDGNLAQAGASRQDIDLIWGAVLTRYLTTVKFAGYGNVRSSGRVQTPTLALIVEKERERLAFVPEDYWQIRGAFAVGDESFTAPHATARFKVEAEARSAMDRVQNAHSATVSAIEKKTRRVAAPAPFNTTSLMAAAAAEGIRPARCMRMAESLYMDGFISYPRVDNTVYPASLDLAEVVHMLEGNPAYRPYCAQLLSQGPLHATRGKKEETDHPPIYPTNVATPDTLPAAEFKLYNLIARRFLATLSDAALIEGTKVSLDVAGEPFTAKGDVLKEAGFRAIYPYGLKKDEQLPTLNQGEQISFEGATLEQKQTEPPARYSQGRLIQEMEKRGLGTKSTRHSIIERLYTVKYIQNDPIEPSALGMAVCDALGQWAPHITTADMTAELDREMDAIAAGRKTREDVVTHSRDLLSEQLSELIPHSEQVKDALADAVAADAYVGKCPRCGKDLQLRVSQKTRSMFIGCAGWPDCEVTYPLPKGRIEATDTPCPVCGMPQVKVSPFRAKPYLHCIDPQCASNQEPELVVGKCPTCKANGIDANLVARKNPRTLKRSITCENFDECETRYPLPQYGTLEATDEVCEHCGAPMVTVVTNRGPWKLCPNFNCPGKVEAETAQKAASSQSRRSGSRRSRAKATKGK
(685) DNA topoisomerase, type IA, central domain protein [Methanocorpusculum labreanum Z]
3
MHLIIAEKNIVAERIAAFLAGKAKVQVTRDGAAAHYVFDDTVVMGLRGHVVEVDFVEGYNNWRSVEHPPRSLINADIVKKPTEKKIVGLMQKFGKKATRVTIATDYDTEGELIGKEAFELIRAANPKVPIDRARFSAITKDEIVKSIKEATSLDFNLASAGESRQIIDLVWGASLTRFLSITAHRGADSILSVGRVQSPTLAMIVDREREIEAFVPTKYWMLSLATEKSGIGVEARHVHGRFTDSAEAKAAYDATVEPLRVTDVITGHKVDRAPTPLDTTALIVGASRLGISASYAMNRAEDLYMRGFISYPRTDNTAYPKSLKISEQLAIFAHGAFSKEAGYVKDHLRSVPTRGKKETTDHPPIYPTSLANREEIGDDVSWKLYEFIVRRFFATICIDAEWETMKVNLLAGSEPYTITGGRILEAGWRGIYPYSKAEENLLPAFTLGETLPLLAKTSDEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVISKLSGRKYIEGNPMKPTIVGRAVTESLEEFAGTITEPTMTKTLEEHMGDIAAGTKTINAVLSESRKMLTGIFDDLEKNEAAIGRDLMERTREEQTIGPCPVCGKPLRIKRVGSSQFIGCSGYPDCTFNTGLPPATWGNAIKMDEVCGIHGLNHVQLLRKGAPAWKIGCPLCSHIKSNTESFLLMPGMTAEGVQKLNAVHIYTLSELISRGPEELSKSLGLSKSEAEKLIREAGSVLALLKKRTELKKFVSSHVAPKRGRGHSKVSAALISLGVVDVEALSRADPKDLLETKLSEAEAASLVAEAKSMVNISRMKEYGVPAITLKKYVNAGFDDPEKFISVHPAGLSLATGVSVTTICNHQKLVAEKLCRPCPEKISKAAFEEGIAPLRKKAEPELLTPLALAGVYSPDLLVKADAKTLAKVTGIDEKQIVNLQKYAQKVLEK
(691) DNA topoisomerase 3-alpha [Mus musculus]
3
MIFPVTLLAFQWHRRPGGRALSRAAMEVAFRGVRKVLCVAEKNDAAKGIADLLSNGRMRRKEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFIDIKKTLERETHHCQALVIWTDCDREGENIGFEIIHVCKAVKPNLRVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEVFHKIKVTHDHKDGTVEFNWKRYRLFNHTACLVLYQLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGGPTPRNGSKSDQAHPPIHPTKYTSGLQGDDRRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLIILARNYLDVYPYDHWSDKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICEGKKDKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERTEMAQQEEIYPAMPEPVRKCPQCNKDMVLKTKKSGGFYLSCMGFPECRSAVWFPDSVLEASRDNSVCSVCQPPPVYRLKLKFKRGSLPPAMPLEFVGCIGGCDETLKEIFGLRFPRALPRASQPSGHLQASQALNRMDSSQHNLSQPLVNRHTRPSKTVAQALLPPTTAGESNSVTCNCGREAVLLTVRKQGPNQGRHFYKCSNGDCNFFLWADSSHSTGGGTPTSASGPPGSSVGCPSSVGSHMDGFGSLGSDSDGGTPCLCGQPAVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENVAPGSFAAPAWPGGRGKAQRPEAASKRPRAGSSDAGSTVKKPRKCSLCHQPGHTRTFCPQNR
(697) DNA topoisomerase [Alkaliphilus metalliredigens QYMF]
3
MSKSLYIAEKPSVALEFAKTLNIKGNKKDGFIESNEAVVTWCIGHLVTMSYPDKYDDKYKKWVLKDLPFLPNKYKYEVIKNVKKQFDIIKTLMKRTDISTIYVCTDSGREGEYIYRLVDEMVNVKGKTKKRVWIDSQTEEEIKKGVKNAKPLDEYDNLANAAYLRAKEDYLMGINFSRLLTLSYGSALSKRLGKKYVVIAVGRVMTCVLGMVVQREREIREFVKTPYYKIISNFQLDQSMDYDGEWKAIESSNYYMSDLLYKDIGFKEVKSAEKFIRELKEDNTELTAVVETIKKKKETKNPPLLYNLAELQNELSKKLKINPDETLKVAQKLYEKKMITYPRTDARVLSNAVAKEIHSNLKGLLRVKQSCQLEPGDEGINDFIQKIVNEGLYKELQKTKYVNDKAITDHYAIIPTGEGLGSFNRLTDYEKETFLLIVRRFLAIFYPPAIFSQLSITTKIKTESFFTTSKVCIQEGYLEILNDGKKDGASSLDKEETLKKLKKGQTVKINKLEIKESETTPPKRYSSGSIILAMESAGKLIEDEELREKIKGSGIGTSATRSGILNKLQQISYIALNKKTQILTPTSLGESIYDVVDESIPSLLKPELTASWEKGLGMIANGEIQCDEYMIKLEAYIRKNTQKVLKLSNQPNLLNSRSIKSTTNKGNQDTKGKRVGRLALGKCIACETGEVLENSKAFYCSNWKQNCKFTVWKDSLKRYEQEIDEEMIKALLEKGQIDKVSIVLPQTNEKCTASLEFKDNKKGELQLKNVTPTTE
(698) DNA topoisomerase 1 [Methanosphaerula palustris E1-9c]
3
MHLIITEKNIAADRIAHILAGKTYVEVKKDGGVSTYSFNDTVVVGLRGHVVEVDFEPGYTNWRSEVNTPRSLISARTIKAPTDKKIVTLIQKLTKKADHVTIATDFDTEGELIGKETYDLVKAVKPDVRVDRSRFSAITEEEIQTAFAAPAELDFALAAAGEARQLIDLIWGASLTRFISLAAHRGGKNILSVGRVQSPTLAMMVDREKEIEAFVPEPYWVLTVDSNKDGEPVLARHTTARFTDVAIAEEAKEATRAPLMVTEVKEGSKVDRAPTPFDTTGFIVAAGRLGFSAANAMRIAEDLYMHGYISYPRTDNTIYPRSLDLNGVLKTLQKTELSSAVIWVMANRRPVPTQGKKSTTDHPPIHPSGAATRAELGDERWKIYELVVRRFLATLSPDARWMTMKVLFTAGNEPYTTTGATLLEAGWRTVYPYSDATEHPLPRFAVGDSLPIEQVNLDRKETQPPPRYTQSRLIQQMEELGLGTKSTRHEVIGKLVGRKYIEGNPLRPTLVGRAVIESLEDHAAAITRPDMTQTIDAHMQQIKERKRTRDDVVTESRAMLNRAFDELEEHQSQIGEDIMGRTVEEMILGPCPVCGSDLRIHHIRNSSQFIGCTRYPDCRFNIGLPLTQWGWAIRTDTVCPTHHLNHVRLIAKGSRPWDIGCPLCHHIESNQETMVLIPSMTEEILGRLQQHHIYTVHEVADAPPEALASAAEISSTAAEHLKSEGEAVLGLLRLRSELRKFVRKQVPPRRGRSHAKIMKHLHANGINTIADLAKADPTLLRTAGVGEKEVTSLLMQAKEYCNDKTLRAIGVPAISLKKYYAAGIQSPEDFCRYHPVYLSVKTGISPDTTFRHAEMVCIAQNRPVPRKVTRAMLERGRAELLTIPGLGETTIEKLYSGGVIDGMTLASADPAALASHSGIPLKKVQEFQSRLPGSSQAS
(703) DNA topoisomerase [Gallus gallus]
3
MNFQARLLASCGVRMLPQPWRGFSRAAEGPAVQRIRKVLCVAEKNDAARGIADLLSNSRMRRREGFSKFNKIYEYDYQMFGQNVTMVMTSVSGHLLAHDFKLPFRKWHSCNPLALFDAEIEKYCPENYVDIKRTLEREVQQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVFRARFSEITLHAVRRACENLTQPDQKTSDAVEVRQELDLRIGAAFTRFQTLRLQKIFPDILADQLISYGSCQFPTLGFVVERFKAIQAFVPEAFYKIKVTHDHEDGNVVFNWKRNRLFNHTACLVLYHMCMEDPIATVVEVGSKPKSKWRPLPLDTVELEKLASRKLKINAKETMRIAEKLYTQGFISYPRTETNIFPKELNLSALVQHQTQDPNWGAFAQRILDQGGPTPRNGTKSDQAHPPIHPTKYTANLQGNEQRLYEFIVRHFLACCSQDAKGQETTVEIDIANERFVAQGLMILARNYLEVYPYEKWSDKVIPLYQKGSRFQPTTVEMVDGETSPPLLLTEADLIALMEKHGIGTDATHAEHIETIKTRMYVGLTADQRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICEGKKDKSIVLHQQVQKYKQVFIEAVARANKLDQALAQYFGEATEIVEQEEVYPAMPVSIRKCPQCNNDMVLKTKKNGGFYLSCTGYPACKTAVWFPDFVLDVAKDESICAVCKPHPVHRLKFKFKRGSVPPTMPLDFVGCIGGCDQMLKELLDLRYSHRSSQSGQSASQQANQLQVNNSFNRANSENRRVGGTTNMATGHLLYLSSTRAPRPAPSAAPDDGNNAVVCNCGNEAMLLTVRKEGPNQGRQFYKCSANTCNFFLWSDQQSEDRSNAAPRGSAPPRAFGARGPANSQRPGGKRGPEHFGSSNNSSSGDSTVCRCDQPAVTRTVQKDGPNKGRQFHTCSKPREQQCGFFQWADENVAPGASGDFSFNHFGSSEYSRELGSKAKRPSNLSHGATAKKPRTCSICHQPGHTKKTCPLDH
(718) DNA topoisomerase 1 [Methanosaeta harundinacea 6Ac]
3
MHLIIAEKHNVAKRIAQILAGSKPKVKRVHGIEAFYFDDKVVMGLSGHIVGVDYPPGYNNWQKVDYRDLIHAEVVTRPTQGKIVSALHDLGKDADRITIATDYDREGELIGVEALRIAEDANPTIKADRVRFSAITKGEIQDAFESPGEVDFDLASSGEARQVVDLIWGAALTRFISITSGRLGKGFLSVGRVQSPTLALIVDREKEIEAFKPQPYWEISACLEKDLRVKHEKGRIWEGDLARSIFEELGEVATVVSIKEKTRTDRPPAPFDTTAFISAASGIGFSAANAMRIAEWLYTSGFISYPRTENTVYPKTLDLRALVSIFKKGPFREDAERVLSGPMVPTRGKRFSTDHPPIYPTAPAAKADMKPDQWKIYELVVRRFLATLSGPSRWIVMNVRVEIDGQPFRATGARQIEAGWRACYPYSKAAEEILPQLSEGEKLRVLGKELEEKETQPPSRYGQGRLVKLMDELGLGTKSTRHEIISKLYARAYVQGNPMKPTNTAYAVVEALQQHSPNITKPDMTRTLEEDMTKIANGHVGEEAVIEESRSMLDAVFDDLLRHQEEIGTTLREGLRTDKIVGLCQICGHELIIRRGRRGSRFIGCAGYPDCTFTLPLPKFGMIVVTDKACEEHGMQQIRIINKGKRPWDLGCPKCNFDQWQAKKAEEAKKKTEVDLLAKIPGIGPKTLEKLGAAGVKTALDLAGAEAEALAEKTGLTKKKISSWQLLAKTMVNEAQSC
(720) DNA topoisomerase [Methanosarcina acetivorans C2A]
3
MTVVAFAEKNKAAAQIASILGDGEVDKISVEGLPAYEFKWKGEEWLVMGLSGHIMNYDFPEQYNKWSEVNPGTLLGVDPEKFVTRAEYATAIKKLAKRADKIILACDYDREGENIGFEAKTLAEEVTDVPVARARFSALSPKEVRKAFESPVDPDHNLAMAAETRQILDLKMGAAFTRFVTLSVREKARTKDILSIGPCQTPTCGFVYEREKAIRAFKAKDFWKITAIFGAKGGDFEGTHRAGNIHDKEKAAEIFKRLKGAKEGFVVKKTVKEAKTSPPNPLNTTEFLKRASKFLGISPEVALEVAEQLYLAGFTSYPRTETNKYADDFDFKTLLFDFARQKEYKPFAESILSAPIVPKNGDKDAHDHPPIHPIRVAAKGEISAAVTIPHAAEVYDLIARHFLANLMPAAVFEKTHLHLQVREEPFDSSGTVLKDAGWLEVYPFENKKDKLLPFVEEKEKVDVKKLSNTKSKTSPPKKLTEAELLTLMDKHGIGTKATAPTHIETNKKRGYFETKGKTVSILDTGFTLMDGLSLTVPILVRPDIRAKIEALIQEVEDGKKEFEAALAEGTALIKEMYAQLEANKKELTSNIAGTIKDEAALEDKKNYIGTCKACGHVLRIVQTDTGRFVGCTGYPDCRNSFPLPKTGALTVLRSKECKKGGAAVLKVGNKYNWAVGIGPCFKCELEKECYPPETVGPCPECDGSMFLISFKDSRFLGCTKRCGYTHSVPKTGKLTLLDKTCETCGWKLFRLKEEEKPELDFCVNRRCPEGRKYWKQAGSRTEPRDQAKVAAASSVPAPKVRAGRTPEAKSTPETRSMPRKAESPASGRVSKLSSTASRRKESK
(722) DNA topoisomerase 1 [Mycoplasma bovis PG45]
3
MSYKLVIVESPNKVETIKKYLGDDFNVMASVGHIARLSKKGSMGLGIDMEKWEPEFEIDPTKKDVVKHLKAAVKDADFVYIATDPDREGEAIGDHLVKYLKCKEGKYARIKYNEITKDAILYSVENPTKLDQNLIDAQKTRRMLDRIIGFRLSQLMQKKLSNSPATPSAGRVQSIALKLVVDREKEIESFVPRDYYSVEALISDSLIASIYMSKHNASEKTWVFPEEIESVKKSIDIEPTNILVVKDIKESKKTLPALTPFKQAVLYKRSPFSSSITQASLQRLYEGFGDGGLISYPRTDSTRLSHTFVNATKNYISIKYGDEYVLDKVKGFKGDQDAHEAIRPTDITLLPDEAKNKYDLNNYDYQIYKLIYEHTLMCLITPPLRANKTYKFLKDKLDFRLNVSWVLFDGYYVVKGEMNENCDPDYKIGQTVNVKEFKIENKETKPPARYSEGSLIEKLDDIKVGRPSTFATTVKIILNREYVKSENSALVPTDFGKLILDKLIQGFPDIINEGYTAEVENQLDLIATNKIAVQPVMEDFYNKFKNNYENAAQNLDHTSMSLQKVDETCPNDNGNLVIRRNKRGDKFIACDNFPRCNFTKSYDDGSNKKRFYRKKVK
(733) DNA topoisomerase 1 [Anabaena variabilis ATCC 29413]
3
MPKRLLVVESPGKVKKLSQILGSEWIVRASCGHIRELSDEGEDALGFSMDGGSVQCHYVPRDQRSKETIQQLKSAAKQVSEVVLATDPDREGETIAWHLKEVLGLREPKRVVYTEITASAVQSAIAHPRKLDLNLVGAGLCRDCLDKLVGYKGSPLVWALNNGAKSVGRVQSSTLHLICQREREIQSFVPQDYWSVWVDYVEGFRAFYKGAVNTRSDSPETEVEIHDDAAGNSTTAPESTRVLAEAEANRLVEEARRHPHQIVQYEGKIANRQPPPPFITSTLQQAAGSKLKFAPEKTMQLAQKLYEAGLITYMRTDSVMLSPEFCESARQWLEQNDPQNVPKQVARHRSSKTAQQGHEAIRPTDVFRPSAQLRIELSTDEFNLYVMIWKRAIASQCRPAQLRKTVVITQSGQILWQARGQVVEFLGYTRYWPNLSKDTLLPTLQQGQMVTLENAGHEKKQTQPPPRYSEPKLVQLMERKGIGRPSTYSPTIATLKKRGYVELTKDNLHPTNLGLEVDTFLQKALPDLLEAEFTAKMENALDAIAEGKQPWQIYLTTWNQNYFAPALAKAKTIAVDSGNPTKTFPPRQYDTSRTRCPDCNNFLSKIPSSKLKKKYFLKCTSGCENTVLFWSEFSKTWQAPRTKDDKMAENGQKNHLSPATKLPTQLTAYPCPVCKRPLEEYTYTKDGQKKTMLRCSASSSRTDKKHQDVAYFHTAKGWWSPKFGEINK
(750) Putative DNA topoisomerase III [Leishmania infantum]
3
MGRNVLMVAEKPSLAESIATILSNGSCSRRTRALPVYEYTGNFMGSPAYFKVTSTTGHVFSCDFTSQHQNWDRTDEEQLFTAPITWKDTSGKVSHHLEHESQGCDTLVLWLDCDREGENICFEVMQVVRREIYNHHSIFRAHFSAITAEEIFHAFRNLGKPNKNISDAVTCRQELDLKVGVAFTRFQTKYFQGKYGDLDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVASRGGALLQFEWDRGRLFDETMARLILQRITKSGKVATVVNVSVSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAENLYIRGYISYPRTESTAYPPSFNLAGALAQQKNHSMWGAYVTALLQQGHARPKAGKDAGDHPPITPMRSASPSELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFSISGKVVEDPGFTEIMPHARVEDDRMPTGVHKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKNGIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEEYVTHIAEGRAQLDDVLSYSLDLFFAKFKFFKEHIDVFDALMGASFSAISAAGKPITRCGNCMRYLKHLDTRPQRLYCPYCEVTFALPQGGTIKPYSSFKCPIDNFELVICHIEGGKSFPICPHCYNNPPFEDMRPAIQHHHRGYGGGAAATTAPSTRHMACDECRHPTCEHSLATNYVCDCVDGSCAGSMAFVPRTAGQWKVCCNKCPMMIKLPPTAQRVYVTFEECPECASNCLDIMFPEGKSVLPNRKDRIVACIFCHPGLSPLCEEVRGRIGNFRRIGGAAAGGRGGRGRGRGRGRGRGRGNREDRR
(762) DNA topoisomerase 1 [Mesoplasma florum L1]
3
MAKYLVLLESPSKVEKIKHYLEKNFQEDSFEVLASGGHINRIADSGPWGLGIDLQTMTPTFKIETTKKKNVSEIVKAGKSADKIILASDPDREGEAIAWHLANLFAKDNKEIKRITFNEITESAVVKAFGEMREIDIDLVNAQLSRQMLDKIIGYMVSNSLQKSTGLLSAGRVQTPALKILVDRDKIIKAFVETIYKKIFVMDSKQNVKLFLYKDDNNLVVNDPKNYYISEEQSKVIINNLGEDYKCTKYKAKEFEVRSFKPYSTASLLQDGFSKLRMSAAQITVAAQKLYEAGLVTYIRTDSNRYSSDFVLEAKNFINKNFKGDLFKEAVPVRTQANAQEAHESIRPTDLNQRPENISSQIEDKNMIRLYNLIWWNTVKSLMKGPSGFYHNWTFWNNGYEFKQSWKEVLDLGYNKLDKFETDEDVELDENDDEISNDDEIKPPFEFKENYVFSINKNAIVTEEAKTSPPRMFNQASLVRELKDLGIGRPSTYTPTLSKLKEREYAIPHRGKPFEVTEKGYQAEEFLYNKYEDFFNVNYTAKMEENLDEIAEGKFDYKDWIKTIYEDLNASVKAQIQEAKTSDIKCPRCHEGNLVFIKSKFGRGRGCSNFTTTKCGYREYEQRDGSWLEYVAKPKETK
(764) Topoisomerase I [Helicobacter pylori F32]
3
MKDSVIIIESPNKVAKVKEITGAKVFATIGHFMQLKSYDENNNFKPTFEYDSQKKKRIFEIIEACKNKKVYIATDPDREGYAIGYHFYEKIKKIASSIYRAEFFEITPSGINKGLQNALLFENTNKQMYQSALARRVADMLLGFTLSPYLGKALGQMKGSSAGRVQTPCLKLIVDRDREIEKFKALPENEKVSYQIQAKINDNANREVIIKHCDEKGEEIKFNDKEEALKLFESLKDNKACLLKDLKISVVETKPKKPFITSTLLERASSELGLGIAEVQSLAQSLFEAGLITYIRTDAESLSVEFLNEAESFYLPIYKEVYQKREYKAGKQSQAEAHEAIRITHPHKYEDLESIVYNAGITNQDALKLYRLIFERTIESQGKNAIYDKQDLLFKIKNEYFKCSAKSLKSTGFLAMFSKKELENDDESNDDKEDKEKEQNAQFNLKIDDMLSLNDLVLATIKRNAPSPYKEASFVKLLENKGIGRPSTYASYLSTLLKREYISISQDKKHTITPTHKGKRVIEVFENAYQFIIDLTYTKQMEEVLDEIVENKSSYLDFLQNLATKCPKIEKLERNDDEIKPSSEGQITYIENILRDLQLDLSEEFKNYKEDNRIAKAFLDRYIKEHEFFEKNNKKASSSNNNEIRPATPKQINFAEILAKKHNVKLPKDYKSNIKVCGDFINEYHKK
(768) DNA topoisomerase 1A [Leishmania major]
3
MLRRSVRALEKLVIVESPNKVIKVEGLLSDPKVIPDWSFNNSKLRAISTGAEKAIAMATTGHFMSLKELTWSPQSSSPASGVTAADFPANGLLVSFSLEWELIPGRRIQDTVSHYIEEKADNLTEIIVATDPDREGELIAVHAQNLIRRMFPQLNAPFTRAYMHSITADGIRRAMEERHEAFDYNLANAAEARHAMDRIFGFLGSSVVRYANPQMRSIGRVQTPALILINDREDKIKSYLESHASTFEIQVVCYFTSKHHQRFSQVVKVTPARKGGAAPVDWSDKATVKQRCEQWALSSATHFSVSPGAKPQETVTPPPKPFTMATLIARANRQLHYSSDMVSSCLQDLFQMGYITYPRTDSTRIDESILPSIYAAVRREHGKRLLQEQDGPSKAGVRRSTAQKEAADANVEDAHEAIRPTNIDTTVEELGAVSAPMKHIYDLVRRNTMAVHMIPMKTERIVVLVACKAANGEEVEFELQGKHVVEPGWSAAFHGSKGTATPVTETDQDVEAVEDGGVVVPSISDDEFKAIMDIAAQRGGGTGVQKGSMQLESAQVAENRPSPPLPFSEGGLIEQLKNNGVGRPSTYPMIVKTLLARNYITVNKGRCETTPVGRMLVDTSRATFPSIVDIGFTSAFEKKLDRIAKPRSTKELALPPNVSDADYVLSSFISNFLNYVTEATKAQRVAITTRSLALQQEKRAASNTPMSPTDFQANLEKETKRVLTQVPDLVDNMKSYRTFTALQNSLNDYLRRNFPPSAAAMAPASSSGTARSYGSSSSSSSSTKKKESYGATYRVDKKTPRHFRAKLKKAKK
(783) DNA topoisomerase 1 [Xenopus laevis]
3
MSEDHVQNDSQIEAVFRVNDSHKHKKDKEHRHKEHKKDKDREKSKHNNSEHRDPSEKKHKDKHKNNDKHREKDGEKHRERDGEKHRDKNGEKHRDGEKHKEKDIEKHKEVEKHRVKDGEKHKEKDVEKHKEKDVEKHRDGEKHKHRDKDREKKKEEKMKSSSGGVKVKKENGFSSPVRVKDEPEDQGFYVSPKENKAMKRPREDDEDYKPKKIKSEDDKKGKKRKQEEEDIKPKKKSKAKGNEEGVKKKKVKKEEEEKWKWWEEERHRDGIKWKFLEHKGPVFAPPYEPVPDNVKFYYDGNLVKLSPKAEEVATFFAKMLDHEYTTKDIFRKNFFKDWKKEMTTDERNLITNLSKCDFNAMSLYFKEQSEARKNMTKEEKLKIKAENERLLQEYGYCIMDNHKERIANFRIEPPGLFRGRGDHPKMGKLKKRIMPEDIIINCSKDSKIPVAPAGHKWKEVRHDGKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKMCVEKIRNTYKEDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLFQELDGQEFVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPDDDLFDRLNTSILNKHLQDLMEGLTAKVFRTYNASITLQQQLDELTNSDDNVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQGKIDAKKDQLADARREFKSAKADAKVRRDEKTKKLVESKKKAVQRIEEQLMKLEVQATDREENKQIALGTSKLNYLDPRISVAWCKKYGVPIEKIYNKTQRKNLLGPSIWQTTTSNFNAEQRCFS
(784) DNA topoisomerase [Streptococcus gallolyticus UCN34]
3
MVSSLKYLLLAEKPDQAKKYATALGNPKNEKGVWRVQSSVLNAEVIVAPAVGHLVERINPYTNFENWEMTNLPALPEGFSYEPKKDTIKRFNAIKKAVKEVDAIIIGTDPDREGEAIAYRILELIPEALRKIKYRLWANSLTKRGLEQAFANLRSPTDSINYFHEADARSDADWLVGFNLSPFVTIKMKEEGYLDKKDHSMSVGRVQTPIVSLIVRNDEAIENFKPSPYWRLKLIDSEAEVIFSNDIKYQSQMEAEQVLQQLANTAVVKTVTSEEKAQEAPKLYNLTNLQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFSYLVDHIEEYQKAINKQLETPNRSPRKNYVNDKKVLEHYAIIPTENIPDLSELSDDEKLIYQKAVFRTLLMFTPDYRYQSTSVILDNHGLEFKATGTVTKDKGWRGYFAVKKEDKELPHYQEGQEVIVDCNLLEEMTKPPTRITEQILLKKLLPKYHLGTSATRDGMIDLIQDKGYVTKHKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVNKIKWAITKQIEKGKQL
(788) DNA topoisomerase 1 [Methanocella arvoryzae MRE50]
3
MHLIITEKNITAKKIAQILFGKGTKETKVEGVSVYSSGDTSIVGLSGHIVNIDFPEQYNNWSVTAPKDLIRAETEMRYTHKKIATALKKLSKDATSVTIATDYDREGELIGVEAYRIISGFKPDIKFDRAKFSAITKPEIDRAFSNRVPLDFNLAAAGEARQKIDLVWGAALTRYISLTCGRLGKSFLSVGRVQTPLLALLVDREKEIKAFVSTPYWEIYATLGNGTDFTAKHECNRFEDKKKADSVRAKLGSTGTVVEYKKDARSDAAPIPFSTTEFIRAASSIGFSAANAMRIAENLYVNGWISYPRTDNTVYPSSLNLRDVLQNFAAGEFGEYARKLLAMKTLVPTRGKKETTDHPPIYPVSSAKKSDMADDEWRVYELVVRRFFATLAPAATWETRNTTVDISGEKFKASGSKLTEAGWRYYYPYGMPKEEVLPALEVGETLKVKKIEMPEKMTQPPTRYGQGRLVKMMEDLGLGTKSTRHEAIQKLYARNYVHGNPPQPTNTAIAVVDALERYADLITKPDMTSKLEQDMDLIADGKIKEDAVVDESQNMLETIFGVLDKNHDEIREVLFDGLREDKILGKCQTCGSDLMVRKSKKGGRFIGCTGYPNCTFSLPLPPSGTIVATNKVCERHGLSHIKITTGGKKPWELGCPQCNFEEWQKKKKEAAAAPGEATTGTATAPKKSAPKKVMAKTGGSDENTAEPKKPAARKAAPKKKVIEKAPEA
(795) DNA topoisomerase 1 [Mycoplasma pulmonis UAB CTIP]
3
MLNYLNMNKLVIVESPNKIKAISKYLGKDYVVKASVGHIAYLPASGAYGLGIDLENWQPLMKMDPEKRAICKELKEAADKSELVYIATDPDREGESIGQNLVDILKLKNYKRIVYNEITEQAIKNAINNPKMLDENLITAQKTRRMLDRIIGFRLSKLMKHKFSNIPSAPSAGRVQSIALKLVIEREKLVENFVAQKYFNIIANLDQDYQALLYLEENQGDKNWINEDQVDKIYNSLSGKLTIKKIKHSTRKDSKATPFKQAVLYKRSSLTSTQVQSASQKLFEGFGDDGLITYPRTDSTRLSQYFIENAHKYIEKTYGLEYVSKEIKGFAGDQDAHEAIRPTNLELTPEKARSKYNLKREEYETYKLIYNNTLQAIMSVPIREITSYTLEDNGNIFKFYESKILFDGYFKAIGFPEIKAPYSQNKKLQEDDIIEVQEYIKQEKTTKPPARYNDGSLIEALDNIKVGRPSTFATTVNILKKRGYVDQIERELIPTNFGKEVNEKLITGFPTIINEDYTASVEKNLDEIAEGKSDHKILMSEFWNLFEKNIDDAYKTMEKTILIPSFVGENCPLDNQPLVYRKNNYGKGRYIACSAYPKCSFTRSEQKFNFFKKTFLKDRLNEEQK
(805) DNA topoisomerase 1 [Rattus norvegicus]
3
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSDKHKDKHKDRDKEKRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKLEEEEDGKLKKPKNKDKDKKVAEPDNKKKKAKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARKDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
(806) DNA topoisomerase I [Methanocella paludicola SANAE]
3
MHLIITEKHDAANKIAGILFPDRSAERHGGVTVYRSKAAGAAVVGLAGHIVALDFPGEYSRWSAHPPSTLIGAPIVSVPTKKDIIGALASLAPSATKVTIATDYDREGELIGVEAYNIIHRLTKAPFERVHYSSFAKQEIEQAFARPVPLDFNLAAAGECRQEIDLVWGAALTRFVSLAGNKAGKDFLSVGRVQTPLLAIIVDREKEILAFVSKPYWELVATLLKGQEAFTAGHAKGRFDKKEEAAAIHKKLGKTALVKGVLRDRKKEPAPVPFSTTEFLKAAASIGYSAASAMQVAEELYINGWISYPRTDNTVYPATLDLRQTVGMFKASPEFAKSALELLGQKTLTATRGKVESKDHPPIYPVACASKTQMDERKWKLYELVVRRFFATLSPPCEWEMVKASIDISGEPFISDGKRMSAPGWRKHYPYGMPKDEVIPPLAVGDVLAVKKVDLLEKKTEPPRRYGQGKLIETMEKLGLGTKATRHEALSKLYNRGYIEGNPPKPTQTGITLIDALKAHAGAITSPGMTARLESDMDGIAESRLRKDDVTGESKAMLRTIFDQLESHRADIGRTLRAGSAMDSPIGPCPKCGSPLVIRETKADKRKFIACTGFPECRNTYNVPPGTLKFDKKACEKHKLHIVKVTPPSIIDSQGKKVKGKPYEYGCPACKKEAFYKPP
(816) DNA topoisomerase 3-alpha [Drosophila melanogaster]
3
MKAVLTCFRPVVASHRRYCANPGQAMKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHMMQLAFQVSYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREGENIGYEIIDVCRAIKPNISVYRATFSEITTVAVRRALQQLGQPDKRQSDAVDVRTELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTLGFVAERYKEIEAFVSEPFWKIKVLHTIDDLTVEFNWARNRLFDKEACENYLLLCLAEPDPRALVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMTIAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIEWGPNPRNGNKSDQAHPPIHPTKLAENLQGNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNYLDVYVYDKWSAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEKHGIGTDATHAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQLRAEFELDLKLICQGQKDPKVVLTEQIAKYKQAYQQITDKITAMDAKISARINETPAANSAVQEGADGSAPSHGIIQSIFQCPKCNEAPLALKPKKNQQGWYIGCNNFPDCKNAVWLPTECKDASVLDECCPTCGDGYRMLKFRLSTPYYRGVFGTPSGWYKTCLPCDNLFRTTFNINLDSVKKVGGIVGEVRGGGGGPGPGPGGGGSGRGAGSGGWSSGPGGGGSGGGGGSGGWGSGTGGGGSGGWGSGTGGGGLGGGKGKKPGGESKKSATKKPPNEPKPKKTKEPKAAPNKKTSSKSSGSIRSFFTSAAPTNSASNGLDEFFDSNDGFEDAMLAAAESVESSSQPKTISMVPLDDDIAAAFAADDDAEFEALVNGGTMPTESNGDQQLDKSLSEWIKEQDKADERPMLWGTRERASLGTAAPTPPPKPAAKRPRWDSVERDSTPPSSVPESETVLCTGCQQPARQNTVRKNGPNLGRLYYKCPKPDECNFFQWADEPPSSAKSKNSTGSAPQSTTSWGSNRVVTLPSIQQSNSQRGQSSMRSNSSSTVTITQTKTKQQERNTATPGDGEEVMCNCGQLASQLTVRKDGPNQGRPFYACPTREKSCGFFKWGDEDQNQGASSTSWGSANRNPPGRSQPTAITSDGPKTRRCGLCRKEGHTRNKCPRKDEFDM
(817) DNA topoisomerase 3-alpha [Drosophila melanogaster]
3
MKAVLTCFRPVVASHRRYCANPGQAMKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHMMQLAFQVSYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREGENIGYEIIDVCRAIKPNISVYRATFSEITTVAVRRALQQLGQPDKRQSDAVDVRTELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTLGFVAERYKEIEAFVSEPFWKIKVLHTIDDLTVEFNWARNRLFDKEACENYLLLCLAEPDPRALVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMTIAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIEWGPNPRNGNKSDQAHPPIHPTKLAENLQGNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNYLDVYVYDKWSAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEKHGIGTDATHAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQLRAEFELDLKLICQGQKDPKVVLTEQIAKYKQAYQQITDKITAMDAKISARINETPAANSAVQEGADGSAPSHGIIQSIFQCPKCNEAPLALKPKKNQQGWYIGCNNFPDCKNAVWLPTECKDASVLDECCPTCGDGYRMLKFRLSTPYYRGVFGTPSGWYKTCLPCDNLFRTTFNINLDSVKKVGGIVGEVRGGGGGPGPGPGGGGSGRGAGSGGWSSGPGGGGSGGGGGSGGWGSGTGGGGSGGWGSGTGGGGLGGGKGKKPGGESKKSATKKPPNEPKPKKTKEPKAAPNKKTSSKSSGSIRSFFTSAAPTNSASNGLDEFFDSNDGFEDAMLAAAESVESSSQPKTISMVPLDDDIAAAFAADDDAEFEALVNGGTMPTESNGDQQLDKSLSEWIKEQDKADERPMLWGTRERASLGTAAPTPPPKPAAKRPRWDSVERDSTPPSSVPESETVLCTGCQQPARQNTVRKNGPNLGRLYYKCPKPDECNFFQWADEPPSSAKSKNSTGSAPQSTTSWGSNRVVTLPSIQQSNSQRGQSSMRSNSSSTVTITQTKTKQQERNTATPGDGEEVMCNCGQLASQLTVRKDGPNQGRPFYACPTREKSCGFFKWGDEDQNQGASSTSWGSANRNPPGRSQPTAITSDGPKTRRCGLCRKEGHTRNKCPRKDEFDM
(818) DNA topoisomerase 3-alpha [Drosophila melanogaster]
3
MKAVLTCFRPVVASHRRYCANPGQAMKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVSGHMMQLAFQVSYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREGENIGYEIIDVCRAIKPNISVYRATFSEITTVAVRRALQQLGQPDKRQSDAVDVRTELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTLGFVAERYKEIEAFVSEPFWKIKVLHTIDDLTVEFNWARNRLFDKEACENYLLLCLAEPDPRALVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMTIAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRDWGAFAQRVIEWGPNPRNGNKSDQAHPPIHPTKLAENLQGNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNYLDVYVYDKWSAKQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEKHGIGTDATHAEHINTIKERGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQLRAEFELDLKLICQGQKDPKVVLTEQIAKYKQAYQQITDKITAMDAKISARINETPAANSAVQEGADGSAPSHGIIQSIFQCPKCNEAPLALKPKKNQQGWYIGCNNFPDCKNAVWLPTECKDASVLDECCPTCGDGYRMLKFRLSTPYYRGVFGTPSGWYKTCLPCDNLFRTTFNINLDSVKKVGGIVGEVRGGGGGPGPGPGGGGSGRGAGSGGWSSGPGGGGSGGGGGSGGWGSGTGGGGSGGWGSGTGGGGLGGGKGKKPGGESKKSATKKPPNEPKPKKTKEPKAAPNKKTSSKSSGSIRSFFTSAAPTNSASNGLDEFFDSNDGFEDAMLAAAESVESSSQPKTISMVPLDDDIAAAFAADDDAEFEALVNGGTMPTESNGDQQLDKSLSEWIKEQDKADERPMLWGTRERASLGTAAPTPPPKPAAKRPRWDSVERDSTPPSSVPESETVLCTGCQQPARQNTVRKNGPNLGRLYYKCPKPDECNFFQWADEPPSSAKSKNSTGSAPQSTTSWGSNRVVTLPSIQQSNSQRGQSSMRSNSSSTVTITQTKTKQQERNTATPGDGEEVMCNCGQLASQLTVRKDGPNQGRPFYACPTREKSCGFFKWGDEDQNQGASSTSWGSANRNPPGRSQPTAITSDGPKTRRCGLCRKEGHTRNKCPRKDEFDM
(850) Topoisomerase IA [Leuconostoc citreum KM20]
3
MPNYLILTEKPSAAANFVKALGGKNGQFDTFTYTITNLRGHVMTLKDPEEMVSEDLKKQYKSWLIKHLPWNLNDFNWARTYIRQRNLRTGKVASTKQLVDDLKKEAANGYDAIVIATDTDPSGEGELLAWEALEAIKWRGQVLRANFMDESVKGIQTSMQHLRDVSDKNQDGEYIKGESRNRWDFASMQLTRIATTAAKKQGFKVVAREGRLKSVIVWQIYAQLEAIKRYVKKPYFEVKFKDLAGHIFGRITPEGDVIPWRFDSKAVAQQDLLQYHESAVTNERYQTRTQAPGKLLDLAGLAAILAPRGFSAKEVLSTYQKMYEAQVVSYPRTEDKTVTPEQFNELLPKIDQIAQVVHVDTALLTHRQPRATHVKNQGAHGANRPGENVPTDLATLTKFGASAQAIYEVLAKNYLAMLAEDYVYDHVTANLTDYPIFKTAYNVPVQLNFKAVYDSQRAIKVDDDDETAVMGQLGPTAQPYLYEGANKKPQAPSTKWIMAFLEKHNVGTGATRVSTLSDMSRGTKAMIKETRGKLTLTETGNVSAVMVKGTWIASPKITKRLFEMMDQVGRFEMTMPKLLDSVTQVVVHDMPIMVANAEQLETLLGQPKIKPKRPVSEKTTGQFKGEEITFAKEWSGHVFTDEELTKLLNGAEISFEAKSKRGKLYTATGTMAKQTYKGRTFYGFKLKPKPKK
(851) DNA topoisomerase [Bacteroides vulgatus ATCC 8482]
3
MIAIVTDRPNVGREIARVLGAGRKENGYMTGNGYMVTWTYGNMLSLAMPKDSGTARVEREDLPLLPPSVLTVRHVKTDTGWNPDINAVLQLKVIAKVLNACDTIIAATDASREGEMLFRHLYGFLGCKQPCLRLWISSLTDEAITEGMANLLPCDRFDNLFLAADSRNRADWLLGVNSSHAICKAVGFGNNSLGRVQTPVLAEICRRYRERENHMPADSWPVFISLCKNDRILKMRHVDDLVARREALALYEDCKAAKNARITAVRKRTEEIGAPALYNLAELQKDANRYHGLTAIQVQEIAQSLYEKRLISYPRTSSRLLPGDVYDTLPPVMEKMLSRKEFRQYAGMVDLAAPQDSIGAQDTMEHHAIIITGIQPGKLGREEMQVYTLIVGRVLETFMPPCKVEYTTVDAVCAARKFRIRTYRILEKGWLGIFEREHIVAKGCMPCPMLPEFFQEEILPVAGCSLIHKKSLPVSPYTDEELVDYMDKAGLGTVSTRTNILRTLLERKYIRYSGKYVVPTPKGLFLYETVRGMKVADASLTSGWETELARIERGELSQEEFLDGVLETVNEVTGEIFRNHPVEKRPQGTI
(858) DNA topoisomerase [Bacteroides salanitronis DSM 18170]
3
MEHTLILTDKPEVGKTIARIIGADKRGNGYMAGGGYIVTWTFGNMLSLAMPKDYGKARVERKDFPLVPRPFQLMVKHVRTDNGWIPDINAVKQLKVIEKLLPECSRIIAATDASREGELLFRQLYRYLGCSLPVLRLWISSLTEQAVREGMKRMQPLEMYDGLFRAGDCRAKADWLLGMNASYALCRATGLGNHSLGRVQTPVLAAISGRYRDRENHIASDSWHIYVSTAKEGIPFKLRSVDTFHDRDRAGEFHRDCSHAGGLRITTVTRWVKELPPPALYSLGELQKDAGRYYGLTVCEVHDIAQSLYEKKLISYPRTSCRTLSPDVAAMLPDIMGKMLAWDGLKAYVQEAGIDPTCLPEHVVGYDSAAHPAIIATGVCPGRLELDRREMQVYLLVVGRMLETFMPPCKVECTTVDAVCAALRFRADTFRIVEQGWHGIFGRKGDIAPEDAVFLTLPDISAGETLPVPACSLVRRRSLPPPPYTDAQLVEYMEKAGLGTSSTRAAILHTLLDRKYIRYSGKYIVPTRKGLYIYETVRGMKIADPSLTSGWEAQLEDMEQGKLAQETFLKEVSRLAGEVTDEIFRLCGSKGEKSEDDTV
(865) DNA topoisomerase 1 [Methanoplanus petrolearius DSM 11571]
3
MHLIIAEKNIAAQRIAGILAENKKPSVKREEGVNTYSFDDKVAIGLRGHVVEIDFEPGYSNWRSETHTPKSLIDAGTIKKPTEKRIVQLIKRLAKKADHVIIATDFDREGELIGKEAYEIVRAANKTVPIKRARFSAITKQEITSAFANPAELDFNLAEAGEARQVVDLIWGASLTRFISLAAKRGGNNILSVGRVQSPTLAMIVDREKEIEAFVPEPYWMISLDSETEEEKFEARHTEGKFWDKESAERSLKGTKEPLTVIDIKEGTRADHAPTPFDTTAYIVAASRLGLSASNAMRIAEELYMNGYISYPRTDNTIYPSSLDLKGILTELKKSPFKREVEWVSANMRPSPTRGKKSSTDHPPIHPTAAASKGDMDETAWKVYELVVRRFLATLSPDARWKTLKYTFDAGGEPYASTGQRLDYEGYRIVYTYSQAKEQALPVLAAGEKLPILDIRLEEKETLPPPRYSQSKLIQVMEELGLGTKSTRHDVIGKLFSRRYVEGNPLKPTLVGRAVTESLEDHAGLITKPDMTRTLEEHMEEIKKSILSKDSVVQESREMLHEIFESLEANQEDIGSEIMDKTAEERVVGKCPVCGKSLMIRTTKGMAQFIGCTGYPDCSFNIGLPSGQWGKAIRDNKICEIHGMNHIRLVRKGSPPWDLGCPLCNHISSNLETLNMIPSISKDLISNLHSHNIYTVYEIANENPEKLSKVTGISKEDSEKLIREADEVLELLRKRSELKKFVRKIIPPKRGRSHAKVLNMFFDAGIVDMESLARADKKTLEKMKLSAEEAESLSHEARLVYNKALLKEYGVPAVSLKKYFDAGFVTPEDFCYIHPAYLSAKTGLNIDTVYKHAAIVCEATGVRLPEKVSKKELESGRIELLSIEGLGEAMLEKLYMAGIVSRKKLCSADPEQISKLTGIPSEKITYFQEECK
(871) DNA topoisomerase [Clostridium cf. saccharolyticum K10]
3
MAKALYIAEKPSVAQEFANALKISGRRADGYIESETAVVTWCVGHLVTMSYPEEYDIKYKRWSLETLPFLPAEFKYQVIDGVKKQFQTVSTLLNRSDIDTIYVCTDSGREGEYIYRLVAQMAGVHGKKEKRVWIDSQTEEEILRGIREAKELKEYDNLAASAYLRAKEDYLMGINFSRALTLKYGPSISSFLRSKWTVVSVGRVMTCVLGMVVRREREIRNFVKTPFYRVIGTFTRESMKISAEWRAVQGSRYFQSPFLYRENGFKEREKAEELIAWLSAEGPVTGTVFSVEKKKETKNPPLLYNLAELQNDCSKMFKISPDQTLKIVQELYERKLVTYPRTDARVLSTAVAKEIGKNLSGLKGFSPCASFAAEVLQGTAWKTIAKTRYVNDKQITDHYAIIPTGQTGAVRNLPSLNAKVYELIVRRFLSIFYPPAVYRKYSLEIAAKTEHFFANFKILKEPGYLKVADVSGIRKKDENAEGTKDTAGAAGESSGEQSAGDSRQEETVIGDEAFAAMLEKLKKGMTLDLSGLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLMSISYLSLNPKTQVITPTLLGELIYEVVNASIRQLLNPELTASWEKGLTYVAEGSITEKEYMEKLERFVAGRTYGAVHTANQAGLRRQFELAAASYKGAEKLPGKGAASAEKAGKNVKNSRKKSAKTGGTINEKN
(879) DNA topoisomerase 1 [Methanosarcina barkeri str. Fusaro]
3
MHLIVTEKNIAARRIAAILAPKNPKKDRVSGVDVYRYEIVSDEEKQETVVVGLSGHIVGIDFPKEYNNWQKVESKTLINADIITTPINRKIVTALKGLGKKASRVTIATDYDREGELIGVEALNIIKQVNPDVPFDRVRYSAITPKAIEAAFSNATDVDFNLADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLSVGRVQSPTLSLIVDREKERNVFVPTPYWEIYAELQNTEGKTFSAQHSTRRFLDKKEATKAFKKLGKKAELKGIEKGKKTDQPPAPFNTTGFISAANSIGLSPANAMRIAEALYTNGYISYPRTDNTVYPETLDLRAQIEIFKEGPFKEYADALLEKAELIPTRGKKETTDHPPIFPASLAKESDLKEDEWKVYELVVRRFFATFAGPSEWETMRLKLDINGEEFKANGARLVEQGWRWYYPYNAPEDRLFPELHEGDSLKVIKKDMQDKETQPPGRYGQGRLINIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVMDTLEKYSPTITKPDMTKLLEENMDRIAEGKIKEAAVLEESRDMLKQVFSELDKNREKIVESLQAGLREDKIIGTCSSCGNELIIRRSKRGGRFIGCNNYPNCTFSLPLPRSGQIIVTDKVCEVHGLHHIRIINSGKRPWDLGCPQCNFIEWQKTQQEEQAQQPKKEKPKSIKDLEGVGKATAGKLEEAGITSVEALAEADPVELAKAIKTSVKRVKSWQVSCNGIVTVEGNSTAEGNSTVKGNCTVEDA
(883) Putative DNA topoisomerase [Methylobacterium extorquens AM1]
3
MADLFVIEAPFKAQLLEGILRELHVDAKVQATRGHFMSMPGKLRPLGIDCRMREFMRVPANPEVFMRLRDMARSADNLYIATDADQEGDVIAWDVYEAVRDIHPSPARVRLKSMDHASIREAIAAAGPVEKAAAVPGRARGIIDRMIGGVFGSPEVPAGRVSTAILGLVASRGLSVTKVRLAAPSKDRGRPWLAEFDLAAPLDLPTAERLAKLDLPPLGSRGSPVVHPTKPSHTGDILVRAGDRLDISPAEAAASLQRSYEAGRMSYPRAGSRGMTPETAKQIAGIFRKSGWTAVKTENFAAKGEDETHEAPHPIGAVDPRLNPGRLGQDEGVRTLVAADLVKAGMEHKRETAFAQDLAPFLRAQGLPGEVADFVAGLRPGRDGATLTWHREHGPAYPGQEVWARSGIERRRPDTVLLEAVVKAGLGRPSTWPRHVQTFMDRGLADDDLKLTPRGRAWVEGSYAPLLDPRLSAAIEVACERVDPSLFDDPDREPWEVMVDQIVNLLPPSVRDPLREAVAHEPPRQKIDWVGKLDARPDLVGRLAQYVSRPEYAPDL
(891) DNA topoisomerase [Methanosarcina mazei Go1]
3
MTVVAFAEKNKAAAQIASILGEGEVDKISVEGLPAYEFKWKGEEWLVMGLSGHIMNYDFPEKYNKWSEVDPGTLLGVDPEKFVTRKEYEAAIKNLAKRADKIILACDYDREGENIGFEAKTLAEEVTDVPVARARFSALSPKEVRKAFENPVDPDHNLAMAAEARQILDLKMGAAFTRFVTLSVREKARTKDVLSIGPCQTPTCGFVYEREKAIRAFEAKDFWKITAVFAAKGGEFEGTHRAGNIHDKEKAAEIFKRLKGAKEGLVVKKTVKEAKTSPPNPLNTTEFLKRASKFLGISPEVALETAEQLYLAGFTSYPRTETNKYADDFDFKSLVFDFARQKEYKPFAESILSAPIVPKNGEKDAHDHPPIHPIRAAARGEVSSAVNIPQAAEVYDLIARHFLANLMPAAVFEKTHLHLQVKEEPFDSSGTVLKEPGWLEVYPFENKKDKLLPFVEEKERVDVKKLSNTKSKTSPPKKLTEAELLTLMDRHGIGTKATAPTHIETNKKRGYFENKGKTISILDTGFTLMEGLSLSVPILVKPDIRSKIEALIQEVEDGKKEFEAALADGTVLIKEMYAQLEANKKELTSNIAGTIKDEAALEDKKNYIGTCKACGHVLRIIQTDSGRFVGCTGYPDCRNSFSLPKTGALTVLRSKECKKEGAAVLKVGNKYNWAVGIGPCFKCEFEKECYPPETVGPCPECDGSMFLISFKDNRFLGCTKRCGYTHSVPKTGKLTLLDKTCETCGWKLFRLKEEVEGNESLEEDICINRRCTEGIKYWKKVGPRSGARAQGKISADSGAELGARSTARNKERTTARRVSKTVSVADSRKDRK
(898) DNA topoisomerase [Pyrobaculum calidifontis JCM 11548]
3
MKLIVAEKRSVAKAIAQFLGGSYRAQRVYGVPAYFFNYGGEAVSLGLMGHIMDFDFAARENVWTWIPPEQLFHATPLLVIRDEAAQYVKALQSLARRADEVYLALDADVEGEAIAYEAAIAVRAVNRRARLYRVKFNAVTPKDIRAAFQKPDTLNLKLVEKVFTRMQIDLTLGAVFTRALTLSVRNSLEKGQFLSYGPCQTPVLGIVVNRELERINFKPEKYYVIKAVVDIGGHRVEMGSEVRYKTRAEAEAAASLIKRGVVKAAVYRPHKVEPPEPLETVELERRASRWLGINSKKTLDVAEELYRAGYISYPRTETTIYPPSLDLREVLQELAKGEHGEYARGLLKAGFRPTRGDSDDGAHPPIYPTKGATKDELYRRFGKAAAYAWPIYDFVVRHFLATLSPPAVVEKQKIVVSFGKIELEAEGQRTLDEGYWRIYPWERQAEKPLPVVKPGEAAYAVKVSVVERETQPPPPMTESELLALMKKYGIGTDATMQDHIHTNVKRGYMRLQKGKCTPTPLGMALATALFQYVPELIEPTVRAKIERALNSIVRDGVPPAKLAAEVKAEFAKYFEKLQQHRREIKEALEKALNSSP
(899) DNA topoisomerase 1 [Thermococcus barophilus MP]
3
MVTLIIAEKPNVAKKIAYALAERKPIRKTLYGVPYYELSRDGKKIIVAPAVGHLYTLAPKTKTYGYPIFDIEWVPVYVAEKGKSYAKDYIKALRELAKRADEFIVACDYDTEGEVIGYTALKYACGVDPKKAKRMKFSALTKRDILKAWYNLEPTINFGMADAGIARHILDWYWGVNLSRALTHAIKRASGKWMILSTGRVQGPTLKFLVEREKEIANFKPTPYWVIKMTLEKNGKQYTATYEKERILDEEEAKRIVQEAKKGPAFVEKVEVKQQKRNPPHPFDLGTLQREAYSAFGYSPKKTLDIAQRLYEMGICSYPRTSSQKLPKNLNYKYIIQSLAKIPEYKPFAHELLGKPQLKPVEGQKDDPAHPAIYPTGELPKPGELTQEEKNIYDLIVRRFLAAFADPAVREIMKVIINSNNHHFILSGARTVKEGWLKIYGKYVSFDEVILPKFREGEPVKVIQIKREKKKTKPPARYSPASVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIRVTPLGMKVVEALEKNVPEIVSVELTREFEEKMDEIMKRKLSKDRVIEEARGQLIKILREFKAKELDIGKELMEKLLEREKNKKSKKKTAKELTAEEEEAIKNAVENHEKKSNNLIIVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPSCDVTYPLLQRGKIIPTGKVCPECNAPVVKIKEGKKEYEVCLDMKCKKKMDKNKY
(904) DNA topoisomerase 1 [Methanosalsum zhilinae DSM 4017]
3
MHLIIAEKNIAAKRIASILAPKKPKQSRVNGVDTYQFKNKEETVVIGLSGHIVTVDFPPQYKNWQKVESRELIDAEIVTVATHSKIVSVLKKMAKKATNVTIATDYDREGELIGVEALNILKKANPDLKFDRVRYSAITPKEINDAFSNPVSIDFNLAAAGHSRQVIDLVWGASLTRYLSLVSGRLGNMFLSVGRVQSPTLAIIVDREKERDEFVPKPYWEIDALLEDKNKNEVLASHSKGRFWDKDEADTVMEKVNKARKAVVSQIRKSSKTDKPPTPFNTTELISAASSIGFTASNAMRIAESLYTNGYISYPRTDNTVYPASLDLRAQIEIFSSGIFKEYANELLKKKELIPTRGKKESTDHPPIYPASYAKKSELNEQEWKLYELVVRRFFATFAEPARWETMRIKFEINEEEFKSSGARLVNAGWRWYYPYNAPEDRLLPQMEEKDILSVEKIDMVDKETKPPGRYGQGRLIRLMEELGLGTKATRHETISKLYSRTYVHGSPLIPTKTAYAVIETLEKYAPTITKPDMTSKLEQDMDKIAEGEITENDVIDESREMLQSIFSEFEKCQDKIAESLRAGLREDKIVGSCPECNSKLSIRRSRRGSRFIGCSNYPDCTFSLPLPKSGQIIVTDKSCDEHGLYHLRIISKGRRPWNLGCPQCNFLEWQKSQNNENQEKNEKVTSKNAHKKTVPASKKKSDKVTEISGIGKVTAEKLDEAGIVKIGDLLNADATEISRKTNISVKKIKNWQKIAVPDRQN
(912) DNA topoisomerase [Leptotrichia buccalis C-1013-b]
3
MKKLIIAEKPSLARNIASALDIRVNKEGYMENEKYIVSWAFGHLFKLRDVDGYVGEKRKWSEVKLPFFPKEFEFELKNDLGIKKQYKILKNLINSKEVDEIVNAGDADREGQIIVDIIINAIKTDKKIKRLWLPEQTEETIRKAINNLEDNFKYRNLHNEGLARTYMDWLMGINLTRYISLKANMLFPVGRVLIPVIKYIYDRDLTIKNFSPEKYFTIESETMCNGTLLKLICDKKYNLLELEKAKNYSYELNRNKGIVKDITEKEIILNPPKLFSLSKLQSKLSKEKKISFAKSLETIQKLYEKGFITYPRTNTEYLAEEEKDKVRELIKLYSDYRLEFKDSKKIFDSSKIESHSAVMPTLKIPDMNSLNLEEKIIFETIRNRFISNFLKEQAIINQTEIKIAVGNEIFNLKGKSVKQEGFLKYENQKVDNKLPYFEISQEIDIDFKVVDKLTVSPKKVTEENLSNYLKNPFRKEKKQEDEDDTQEYREIMKGVEIGTEATRTGIIENAKKYGYITSEKQNFSITEKGIKLIELLDLLHINLYAEKTVEFSMLQKDIYNNRKNISDIIEKTENELQNIINQDVEVEKFEKEMEVIGKCPKCNSNIYENSKSYYCSNYKNGCKTSLWKEANYFGQKIKINKDNAKKLLSGEQVVFKIKSKSGKEYNAHFGIEVNGDYLNLQRKDFIKIEK
(913) NEQ324 [Nanoarchaeum equitans Kin4-M]
3
MDWLKLYKEFYKFEDNPFKEGQTIEGQAKIIKEKTKPPARYNEATLLKKMESLNLGTKSTRALIIDILFKRNYVKGKSIYITPLGEKVIEVFEKYLPQIIDVELTRKMEEYLEKIEKGHLEYREKAIEEAKQIIKEVTKEIKEKEKEIGKELYDVYLKARNSQDSRSRKRGT
(918) DNA topoisomerase [Peptoclostridium difficile 630]
3
MKLVLAEKPSVAKTIASFLGAKTRQDGYFEGNDYIITYAVGHLVSLYDMKDYDKDKYSGSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVINATDNDREGELIAFLIFLLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAAGYTRLITDWLIGINFTSVATLKYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYYEIEGHFKAEAGEYKGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAPKLFSLTSLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASKASQTLDKLKVGLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPKSLSKDEQLVYDAIKDRFVANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKNDLLPLVNKDDVVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDTTVLSGYSIGTSATRADVLKKISQVGYVKKKGKSYSITELGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGKYTRKEYLTNIISFIYQNVNIIKQDASKNINTEAYTFDSKTKKFTKTKEKKQKKDVTNTEKEVAISKDSNNKKEVKNGDENQSLGKCPICQGDVLEFDKGFACKNHKECKFVIWKNDKYLSLYKKKVNKTMVKNILKKGETKVKSLTAKNGNKFDATLKYDKNPDTGYFNWKIEFDN
(920) DNA topoisomerase I-like [Leuconostoc gasicomitatum LMG 18811]
3
MTNYLILTEKPSAAANFTKALGGKTGVFNDFTYKIANLRGHVMTLKDPEAMVAEELKKQYKSWLVKHLPWNLSDFSWARTYIRQRNMRTGKVESTKKLIDDLKKESKSGYDAIVIATDTDPSGEGELLAWEALDAIGWRGQVLRANFMDESVSGIQKAMHQLRDVSDKMADGEYVKGESRNRWDFASMQLTRIATTAAKKAGFKVVAREGRLKSVIIWRVYQQLDAIKNYVKTPYFEVKFKDPAEHVFGRVTPQGDVIPWRFATKEEAEIDFSQYHKTDVINEKHQTRTQAPGKLLDLAGLASILAPRGFSSKEVLSTYQKMYEAQIVSYPRTEDKTVTPEQFNELLPLIDQIADVVGVDKMLLTHRSPRTTHVKSQGAHGANRPGENLPKTTQSLVKFGASGPAIYEVLAKNYLAMLAEDYVYDHVTANLKDYPEFKTAFNRPLKMNFKLVYDSQKAIKVEEEEEENSTASQLGPQARPYLHEGANPKPQTPTTKWIMAFLEKHNVGTGATRVSTLSEMSRGIKAMLTETRGKLGLTETGQVSAIMVKDTWIASPKITKRLFEMMDQVGQFDMTMDQVLDSVTKVVEHDMPIMLDNAEQLETLLGKPKQVPKKKVTEKMTGLFKGEEITFAREWSGHIFTDDELTKMLNGAEISFQSKSKRGKIYTATGKLAKQTFKGSTFYGFKLNPKAKK
(925) DNA topoisomerase [Desulfurococcus mucosus DSM 2162]
3
MVSGVEPWMSRGVRIWDLKGRVLVIAEKPKAARKIAEALSPGYVTRRIGSIPVYEINAYGSMILVASSVGHLYELNTGVKGYPVYSYEWVPSHLVNPGKRHAREYLEVLKKLCRGVDYYVNACDYDIEGSVIGYLIIKFNGDEEKALRAKFSSLTREELRQAFNNLAKLDYEMIEAGLCRHELDWLWGINVSRALMKAVEDATGRRIVLSAGRVQTPTLKYVVEKTVERNLFIPLPQYRVTVTAERNGEEVVLEYAGNPVEKHGEARSIVERVRRQGYLIVEEVEGKTYVLKPPPPFNLGDLQEEAARIYGFSPAKTQAIAEQLYLDALISYPRTNSQKLPPTLNYRGILDNLASIGKYSGLVASLLSETRGVLKPVEGEKEDPAHPAIYPTGMKPGGLTDEQWAVYDLIVRRFLAVFAQPARLTHYTVKAVTPSRDAVFKASWQRVEEQGWMKYYGFHTYKSSRAPGLVKGDKLGVVKVSMRESYTKPPKRLSKIDVLRWMESVEIGTEATRAQIIEKLFERKYLFLESKGIGVSDLGFGVVEVVERFFPDLLSIELTRRFEKEMDAIRRGLRSRGQVLEEAKRILTAMLGEFDENRVEAGRQLAVRLGVAEPSRGKCRISSCKREAVEEGLCRHHASAARLIHEYYVEWSRRKEIGFDEYVEKLRKSRNTGKWIKEVIEAGVVKAPRFP
(927) DNA topoisomerase 1 [Ustilago maydis 521]
3
MNSIQVKNEPMLASFASTSTNGKAKRSAKPSLFSGSEVSSDDDEEKPLAKRPKVEDSDSDAPLTSTVSSQNGVQKRSGSSNNDDNDDDSDSDSDAPLTALVKKSNGSDDDEDDDDDDDEGDDDDEEDDDDDDDDDDKPLSKSSKSNRKPPKTMSITGSGEKKWDVLIHKGPRFPDPYQPLPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNAIFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARKREIEERKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHPKAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVFLDATSNFKTNSDREKFEKARKLDTVVKQIRRDVNKNLKSKVRHERQIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCEHAQIKMPDTIHLEFLGKDSMKFEEDLKITNPDVFKNIAMFLKSNGMKDKSGNYVRKKPSDPIFCAPESGSGKMQPLQPNSVNQFLSKYMKGLSAKVFRTYNASVTFQGLLEQTEEWLKSRPNAAEREINQTNLRLAYNEANRQVAILCNHQKTVNPMLLNRNLERTQDKIFQIRYEIMKEQQKILTFHKVSELKKEFKVKEHPFMKQFDKIMQKQDLDAEKVKQYEEQMISDKKSKLESTFKRQQSELQYQLEQKGLTGDDGTPKKGKKAKNVEEEVRSSIKGFKDKKQVDEELKALNETAKRLEKERKTNKSQATSCNFVSSAKKILSKYEMIKKQEAELVNKNNTSDVALSTSKLNYIDPRITLAWLKEWDDRLSDLGQGKAAPKKKVKKEEEENDIKPKKKDAKGAASKKRAAKTGLANSTGDSEKMELGLQVMNISQFFANALQKKFKWAASGDDGRDISAKWVFVKDAQSKMRKLDSAERKGQKGGSMAAMTDAADSKEAQPKVNCVLKKQTSADRKMSKPIKAVDKTEESDDDLSSDSSDDEDKPLAAVV
(928) DNA topoisomerase 1 [Ustilago maydis 521]
3
MNSIQVKNEPMLASFASTSTNGKAKRSAKPSLFSGSEVSSDDDEEKPLAKRPKVEDSDSDAPLTSTVSSQNGVQKRSGSSNNDDNDDDSDSDSDAPLTALVKKSNGSDDDEDDDDDDDEGDDDDEEDDDDDDDDDDKPLSKSSKSNRKPPKTMSITGSGEKKWDVLIHKGPRFPDPYQPLPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNAIFNRNFFDDFKTDLKKYPPRDGTQIKSFDKLDFRDMYNYWRSLKDAELERKKALAPSARKREIEERKAEETKWKICLVDGVEQRVGNVNVEPPGLFLGRGAHPKAGKVKRRISPGDITINHSADHPAPQPPAGMGDWAEVVEKKDVTWLAYWKENINGQYKYVFLDATSNFKTNSDREKFEKARKLDTVVKQIRRDVNKNLKSKVRHERQIATIVWLIDNFSLRAGNEKGEDEAETYGVCSLRCEHAQIKMPDTIHLEFLGKDSMKFEEDLKITNPDVFKNIAMFLKSNGMKDKSGNYVRKKPSDPIFCAPESGSGKMQPLQPNSVNQFLSKYMKGLSAKVFRTYNASVTFQGLLEQTEEWLKSRPNAAEREINQTNLRLAYNEANRQVAILCNHQKTVNPMLLNRNLERTQDKIFQIRYEIMKEQQKILTFHKVSELKKEFKVKEHPFMKQFDKIMQKQDLDAEKVKQYEEQMISDKKSKLESTFKRQQSELQYQLEQKGLTGDDGTPKKGKKAKNVEEEVRSSIKGFKDKKQVDEELKALNETAKRLEKERKTNKSQATSCNFVSSAKKILSKYEMIKKQEAELVNKNNTSDVALSTSKLNYIDPRITLAWLKEWDDRLSDLGQGKAAPKKKVKKEEEENDIKPKKKDAKGAASKKRAAKTGLANSTGDSEKMELGLQVMNISQFFANALQKKFKWAASGDDGRDISAKWVFVKDAQSKMRKLDSAERKGQKGGSMAAMTDAADSKEAQPKVNCVLKKQTSADRKMSKPIKAVDKTEESDDDLSSDSSDDEDKPLAAVV
(930) DNA topoisomerase 1 [Thermococcus onnurineus NA1]
3
MVTLIIAEKPNVARKIAYALAEGRPVRKTIGKVPYYEFTRDGKRIIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNLESTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMVLEKNGQQYTAVYEKERILDENEAKRIVEEAKKGPAFVEKVDVKQQNRHPPVPFDLGTLQREAYSAFGYSPKKTLELAQKLYERGLTSYPRTSSQKLPKNLNFRSILQNLAKLPEYKPFAHELLGKERLKPVEGKKDDPAHPAIYPTGELPKPGELTKDEANLYDLIVRRFLALFMEPAVREIMKVIINSNGHRFILSGARTIKEGWLKVYGKYVKFDEAILPAFKEGEPVKVLQIKREKKKTKPPARYSPAAVIKRMEDLGIGTKATRAQILETLYSRGYIEGKKKIKVTPLGMRVVEALERNVPDIVSVELTRAFEEKMEEIMAGKADKDRVIEESKEQLIKILQQFKEKELDIGKVLMETTGTGVTTSKENAKRAGTVKELSETEEKDVKKTIEKGEKTPLVVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLLQRGRIIPTNKTCCDGAPVVKIREKGREYEICLDMNCKDWKKGKK
(933) DNA topoisomerase 1 [Thermoplasma volcanium GSS1]
3
MQDYFRVIIAEKVDAGRRIAYFLSNGTAKARRVKGLSYIEFESNGKKTLLIPLSGHIVEADFPENFSNWEKTDLKELIDADIVKKVKNKSAYQTLSSFKGKADEIIIATDYDREGELIGVEALDIIKEGQEKVLRAKFSSLVGQEIRNAFEKPIDVNYNLADAADARESIDLIWGAVLTRFFSLATGRLGRYFLSAGRVQTPTLAIVVEREREIENFKPQTFWTISITFQKEGEFQAAYEKKLFDKDVANSVFSSINGRDGTVIKFEKHEESIRRPTPFSTTEFLREASRIGIMPTKAMSIAESLYTRGLISYPRTDNTVYPRAINLRNVLQKFSKSKYSNYVEEILGWEKIIPSRGRTETTDHPPIYPVEMPKEELKGDYARIYDLILRRFISTLYRDGRKTVKEAEIDVNGYKFLARGSQTTDLGWMAVYGYSSRDEFMPDLSEGEILHGTNWLLNEDQTKPPPRYDMASLLKKMEDLNLGTKSTRHDIIGKLIDRGFIEGNPVRPTGLGIAFIDAVKSVNSSIADPDMTAKLEQDMDKIERSLMSKQEVVDESKKMLHSVLGDFINKADDVKSIINTGINAGEAMGKCPFHPDHNLILSKDKFTYRIRCEVDGCRIDFKIKKNGSISLMDQLCPVCGLPLIKIIRRGQSPEVKCIDPGCAYNKEKEDFGECPKDGGRLILRQSRYGKRFLGCSNYPKCTVTYPLPQKGKIEKTGEKCPICGAPLLEAVNGKRRWKFCPNISCEYNKKKSNKVEEKKAGRRKKDASKS
(937) Putative DNA topoisomerase [Lactobacillus brevis]
3
MSIVVLTEKSSQIDPYAKALGTPKKKQGSVWVHSALLNADVQFVAASGHLFKLDGPEDYNDAWRDRSNYEQLPMVPQKFKARIKDARARASFNRIKQAITAADEVILATDPDQQGEVIGREILQRIPGGMEKCQRRLLNSSLTAKGALRSFENLVPMAKQEHLGAAGFLQNRLNWLIGMNLSRVGGIQLKKRGYYFPVAAGTVKTPTLALVVANDQEIKHFKEAPYWQIELTDQANQQRFKAQPSRHFSIEDEAKQALAQVTDTLTIKSVDQVEQHRLPPKLFNLTALQGYAAKKWGYSGTEVLETMEHLYKDLAITSYPRTESTVIEDAEFDYLKANFNDYAATLNLKMAMQVPDARPEFVKTTTDGHPALIPTDKVADLSQLTERERRCYGAVVKRTLLMFAGDCVLDKTVVKGTLGTEQIYEATGQQFKDLGWTEFDVVKTENRELPSYQQGQQVKIETSLVEGKTKVPQRITEGMLFSKLFPKYNLGTPATRAGIVSELIEKNHYIEVKGKRRELYPTSEGINMVAFWQGTLLTDLKLAKSWQDIFDKVIQGNMQPDRYQEQMVEALTDIVADYRTKKPDLPIAPKPHTSYEFKPLTPAVKCPKCHRGELGLLVATNAKNNQFYACSQKKCHFSLPNKYSGIALTSELVRQLATKKQTDWLPEVKSSQGKVYRNQVAFILAEKLKLQWTFKQTAKKTERTD
(944) DNA topoisomerase type IA central domain protein [Atopobium parvulum DSM 20469]
3
MILVVTEKNDAAQQIARLLSESGKPEADKVYNTPVYRFRRGGEDYVAIGLRGHILQPDFPLALKFDKEEGWYGETAEGEHLPADVPDGLERPPYKVKRKPFMADGVDLKGWKIPSLPYLIWAPVDKQPAEKEIIRALKNLAKKAESVIIGTDFDREGELIGSDALAQVLSVNPNLAVFRARYSAFTKTEIETAFNNLVDLDYNLAAAGESRQYIDLIWGAVLTRYLTTARFGGLGNTRSAGRVQTPTLALVVERERERLAFKPEDYWVISGVASPEDDDEATFKMVHQTARFWDQAEADTVYDVVKDQTQATVVEIESRSRKQQPPAPFNTTSLQAAAAAEGISPARTMRLAESLYMDGLISYPRVDNTVYPSSLDLKDCVRTLSAVPQYAPTCKKLLGQPKLHATRGKQESTDHPPIYPTAAANPDSLQPAAWKLYNLIARRFLATLMGPATMSGTKITLDVAGQPFVANGTVLAEPGFREIYPFGLKKDDQIPDVGEGEIVSIKSLSLDAKQTEPPARYSQGKLIQEMEKRGLGTKSTRASIIDTLYQRKYLKNDPVEPSQLGMAIVDALSQFAPHITSPDMTAELESDMTSVAEGKDTRDGVVTHSRSLLAGMIDVLIDHKEDLSEAIADAVTADAKVGTCPKCGKDLVAKSSLKTRGSFVGCMGWPDCDVTYPLPQGRVEPLEGEAGVCPECGAPRVKVQPFRQRAYETCINPACPTNSEPDLIVGECPTCKANGKHGDLVAHKSERTGKRFIRCTNYEECETSYPLPARGKLEKTDEVCPDCGAPMVVVTTQRGPWKLCPNYDCPGKEKKTAPRRGARKSTKSTKSTKAAKK
(951) DNA topoisomerase [Sulfolobus tokodaii str. 7]
3
MNCYPKNYILVIAEKSKAAKKIAEALSDKPTTCKKYSVSYWVVNYKGKVNVVAPAAGHLFNLYGDSSFPIFSMDWKPLWEIDDSAKYTKKYYNLLKDLSKYAIEYINACDYDIEGSVIGYMIIKHFGDLKKAKRMKFSALTKQDIQKAYSNLSPLDYNMINAGIARHKVDWIWGINVSRALMLAVSSVTKKRVTLSAGRVQSPTLIHVVENEIARELYIPLPVYRVRVKIKIGNETFSLSLNRTFEYKEEAQEFANKIKKSRAVVDEVRIEEKPLTRPSPFNLGDLQAEAGRILGYSPYYVERLAEELYLDGLISYPRTNSQKIPPSVDIKSIVNGLEANFKNLVGLVRNITKGEYIVRQGSKDDPAHPAIYPTGNRITEKLGIKQYKLFELITRRFLASISRDAIMITQKIIIRFKDVDISDEITRQKIKFKGWLLLYPYHSVKDEELLDVKEGEEVKIESVSVKMDLAKPDVKRYNKVQLLKWMETSNLGTEATRGKIIETLFNRKYLSQKRGTIYPTSLGIVIVEVLKDYFKDLTSIELTSKMEEKLNEILDGKETVEGVVAETINTLRIYLDNYNKYKDQIGIKLAKILGLMKYKKCKFCDLEAEYDNLCKYHYNAYMKLKETLKVWKERTKLEDKDILKKIYSSKTTGKYIKDMISEMM
(952) DNA topoisomerase 1 [Methanocella paludicola SANAE]
3
MHLIVTEKNITARKIAQLLLGSAKERKVDGVSVYEGDDTAVVGLSGHIVNIDFPDEYNNWQSTAPKDLIWANTEMRYTQKKIATALKKLAKEATHVTIATDFDREGELIGVEAYHIIKDAAPAAKFDRARYSAITRQEIEHAFANTVPIDFDLAAAGEARQKIDLVWGAALTRYISLTCGRLGNSFLSVGRVQTPLLALIVDREKDIKAFTPTPYWEIYATFTNGEEFVAGHTGNRFTEKAKAEGIMARLGRTGKVADYKKEPRVEYPPIPFSTTEFIRAAASIGFSAANAMRIAENLYVNGWISYPRTDNTVYPASLNLKEIVAQFAGGEFGKYAQRLLEQSSFKPTRGKKETTDHPPIYPVASARKSEIKADEWRVYELVVSRFFATLAPPAEYEVRNVCVDVNGERFKATGSMLSTPGYRLYYPYGMAKEELLPELSVGQELAVKNAAMDEKLTKPPVRYGQGKLVKMMEDLGLGTKSTRHEAIQKLYARNYVHGNPPVPTNTAFAVVGALEKYADLITKPDMTSRLESDMDSIAEGKIKEEAVVQESQGMLETIFDDLDKNHNDIREVLYEGLREDRRIGKCPSCGKDLYVRKSKKGGRFIGCEGYPECNFILPLPRMGTIIVTEKNCDKHGISHIRIVNGGSKPWDLGCPQCNYEEWQKKNAAEKVTPVRKSSEPAKKPARKTTKKKAADDKGAPLVKS
(957) DNA topoisomerase 1 [Natrialba magadii ATCC 43099]
3
MELIITEKDNAARRIADILSGGTYDSSRENGVNVYEWGGKRCVGLSGHVVGVDFPSEYSDWRDVEPVELIDASIEKTATKENIVATLRILSRKATRVTIATDYDREGELIGKEAYDIVREVDEEVPIRRVRFSSITENEVQDAFDEPDELDFDLAAAGEARQIIDLVWGAALTRFLSLSAGQLGNDFISVGRVQSPTLKLMVDREREIEAFDPEDYWELVADVAKGSEAQRASETSSGDEPRESEAFEAQYFYRDEDGNEAERVWEEAVAEDVFETLSQRDTATVVDVNRRTRTDSPPAPFNTTQFIRAASALGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPEELLDDFVGHPTLGESAESLLEADEIEPTEGDEETTDHPPIHPTGEIPSRGDVSDDEWEVFELVVRRFYATVAEAAIWEHLKVVAEVAAHRLKANGKRLDKAGYHDVYPYFSTTENYVPDVSEGEEITITDVELEDKQTQPPRRYGQSRLIETMEDMGIGTKSTRHETIQKLYDRGYIESDPPRPTKLAMAVVEAAENYADRVVSEDMTAQLEQDMDAIASGEAGLEDVTNESREMLEEIFANLADSRDEIGDHLRKSLKDDKRLGPCPECGEDLLVRRSRHGSYFIGCDGYPDCENTLPLPSTGKPLILDEECEKHDLNEVKMLAGRQTFVHGCPLCKAEDAGEGPVLGDCPECGDEHGGELAVKTLQSGSRLVGCTRYPDCEYSLPLPRRGEIEVTEEYCGEHDLPELVIHSGDEPWELGCPICNYQEFQARESESGSDLESLDGVGAKTVEKLAAAGIESLADLTEADPDSIAEDVDGVSADRIRNWQASA
(958) DNA topoisomerase 1 [Natrialba magadii ATCC 43099]
3
MELIITEKDNAARRIADILSGGTYDSSRENGVNVYEWGGKRCVGLSGHVVGVDFPSEYSDWRDVEPVELIDASIEKTATKENIVATLRILSRKATRVTIATDYDREGELIGKEAYDIVREVDEEVPIRRVRFSSITENEVQDAFDEPDELDFDLAAAGEARQIIDLVWGAALTRFLSLSAGQLGNDFISVGRVQSPTLKLMVDREREIEAFDPEDYWELVADVAKGSEAQRASETSSGDEPRESEAFEAQYFYRDEDGNEAERVWEEAVAEDVFETLSQRDTATVVDVNRRTRTDSPPAPFNTTQFIRAASALGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPEELLDDFVGHPTLGESAESLLEADEIEPTEGDEETTDHPPIHPTGEIPSRGDVSDDEWEVFELVVRRFYATVAEAAIWEHLKVVAEVAAHRLKANGKRLDKAGYHDVYPYFSTTENYVPDVSEGEEITITDVELEDKQTQPPRRYGQSRLIETMEDMGIGTKSTRHETIQKLYDRGYIESDPPRPTKLAMAVVEAAENYADRVVSEDMTAQLEQDMDAIASGEAGLEDVTNESREMLEEIFANLADSRDEIGDHLRKSLKDDKRLGPCPECGEDLLVRRSRHGSYFIGCDGYPDCENTLPLPSTGKPLILDEECEKHDLNEVKMLAGRQTFVHGCPLCKAEDAGEGPVLGDCPECGDEHGGELAVKTLQSGSRLVGCTRYPDCEYSLPLPRRGEIEVTEEYCGEHDLPELVIHSGDEPWELGCPICNYQEFQARESESGSDLESLDGVGAKTVEKLAAAGIESLADLTEADPDSIAEDVDGVSADRIRNWQASA
(960) DNA topoisomerase [Bacteroides xylanisolvens XB1A]
3
MEGPFTREMLPLAVPSGLAVRRTRTEDGFRDDPVAVRQLEVIRRLLREADGAVTATDTSREGQMVARNLYDYLGFKGKTERLWLSSLTDKAIRKAFLDLRPDSLYEGLYLAGRARREADRIIGYNASLALGMAAGKKNHSLGRVQTPVLALVSRRYLENRDFNAVPYYRLELSVLKDGKELVFTCPEKYTQQQEAVAARNRIAASRVATVIQAERKETVEEPPLLHDLASLQKEANLRMGLTAGQTASALQRLYEGGYISYPRTSCRYIRKDMPEDMPTLLSLLKDDPCFARHAETPEGRVLSARAADDGKVTGHHAIIITENIPGKLPLDEQNLYRMVAGRMLEAFSGDCTKEEADVRIECGGILFEAGYRRTVHAGWKNVHNGTGKEEDTMFPSWGQDEVLPVTDISVRSVETCPVPLFTEASLLSEMERCGLGTPSTRAGVIELLIARRYVERQGCGLLPTPKGLEVYEAVRNKLIADPEMTARWEKDLQEIERGELDADVFIQKVGKYARQIVEELSAVRFEHPGPPRHRCPKCGMETLTLHRKVARCGDPDCAFLLFRTFNARELTDGEMLCLLEGKKTDFLPFVSRKGKPYEASLKMDENYRIEMTFRDIPVERQPLPAGDPSVMQAADIPVETPHPGQLP
(961) DNA topoisomerase [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)']
3
MVVATKGHIKDLPPKSYGVDLSNQFEPEYEWLKGKKSLFTTITTKAKKCSLIYIASDPDREGEIIAKHCFDELSKLKKPIYRLRLKEITKEELQSQIQKKIGLDQQEIESQIARRVIDRIFGFEVSPDLWKHLKIPSLSAGRVQSTVLHWICEREKEIQNFSKENYFQLKLIGTLNENPIELKYQSKEKLKQEEIQTILNEIQILPDPSRLKNIVLSNLKIKKIKRNPPKAFSTASLLESSFRALQFDSKKTMRLAQSLFEGKKLHAGETVGLITYMRSDSTRVSESKQDLGEKYLKEHYPNLLWEGSRNQGKQKKFSQDAHEAITPINPSLSPEQIKSFLTLDEWKLYQLIWERFLTSLLKPEIGEEIVYEFPIGKHIFEHSFETISDPGFKNFPRPKEKREKISLNAKIGDLFFYESYSVEEKETEPPQRYTQGKLIQKMEDTGVGRPSTYATILETLKLRKYIVEYKKNIGPSQLGLKVDSYLFLNFFDLIGESFTKDLESKLDQITDEKASRVKLVANFYDQLKQILKSPRKKMVSIGKENQSKVKYDTDEKQTLSEKVKNGKGSEKKGNTKNQNQSLTYIENKTCPKCLDGYVKTKLGKNGKTIYFCSRYPHCDYITYDN
(964) DNA topoisomerase 1 [Mycoplasma agalactiae PG2]
3
MSYKLVIVESPNKVETIKKYLGENYNVMASVGHIARLSKKGSMGLGIDMSKWEPEFEIDPAKKEIVKQLKTAVKDADFVYIATDPDREGEAIGDHLVKYLKCKEGKFARIKYNEITKDAILYSVENPTQLDQNLIDAQKTRRMLDRIIGFRLSQLMQKKLSNSPATPSAGRVQSIALKLVVDREKEIENFVPRGYYSIEALISDSLTAEIYMPKHIAAEKTWVFPDELESVKKSIDILPSNILVVKDIKESKKTLPALTPFKQAALYKKSPFSSSITQASLQRLYEGFGDGSLISYPRTDSTRLSHTFVNATKNYISIKYGDEYVLDKVKGFKGDQDAHEAIRPTDITLLPDEAKNKYDLNNYDYQIYKLIYEHTLMCLITPPLRANKTYKFAKDKLEFRLNVSWVLFDGYYIVKGEMNESVDPDYKIGQLVSVREFVIEGKETNPPARYSEGSLIEKLDDIKVGRPSTFATTVKIILNREYVRSENAALVPTDFGKLILEKLIQDFPDIINEGYTAEVENQLDLIATNKISVAPVMEDFYSKFKNNYESASQNLDHTSMSLQKIDESCPNDNGNLVIRRNKRGDKFIACDNFPKCNFTKSYDDGSNKKRFFRRKAK
(971) DNA topoisomerase 1 [Dictyostelium discoideum]
3
MEVKQEILTPMKVEKTNGNVPTPPPTTTTTTVMDDDLFDDEASPPQPNKKLKAENGSIKKLTPTPKPAPVTPKPTAAVNGKKPIPKKKPVDSSSDSDSSDSSSDSDSDSSDSDSDSSSSDSSSSDSDVPKKKPISKIPNKPSGTVSKTSKNSPKTTTTTTTTTTTVKSKPAPKVKPEQSSSDDSSSDSSDDSSDDSSSDSSSEEEKPKKKPSKKPAAVKKEITVKKETTTTTKKTPVKKEVEVKKETKTTTTKKVKKEESDDDGEDEKTTTKKKTTTRKRKLKEEEEGEEEEEEGVNKWWDKEDDEDDGTKWTTLIHNGPVFPPAYVPHGIKFMYDGKVVKLTPKQEEVATFYANYLETDHVKKQAFKDNFFKEFKGLLTSEQKEIVKKMDKCDFSHIHTHLKTKKEQRKARSKEEKDAETAEKKKIQEKHGFATIDGFKEKVGNYMIEPPGLFLGRGQHPKTGMLKQRIMPSDVTLNIGEGEVIPPSPIPGEKWKEIVHNNTVTWLAFWRESVNGGFKYVWLAPSSKIKGQADRKKFEVARGLKNCIGDIRKGYQKSFNDESTEKRQLAVALYLIDFLALRVGNEKGEDQADTVGCCSLRVEHIKLESNNTITLDFLGKDSMRYLNTVQIREDAYKVLKTFVKGKKPTDLLFDSLTVTQLNNHLKKQMTGLSAKVFRTYNASITLQKELDKMDTKEFQSIDEKILFYNRCNREVAILCNHQKAPPKNLAETMSKIDEKIQELRDLQDLCRIKIGKTPKSQQEDIESREAERLPKLIQLAITNKKDKDKEKTDKEISFDVKAAFEKSRTLPDAKGKIKEKIAKYEEQIKKQEILKTGKDELKTVALGTSKINYLDPRITVAWCKKNKVPVDKIFTKSLRDKFPWSDVGTDYIF
(973) DNA topoisomerase [Sulfolobus islandicus Y.N.15.51]
3
MNLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVNYWIIKDHDNNKYVIVPAAGHLFGLQGKSGFPVYDVDWKPLWEIDKNSYYTKRYYQLISSLSKYALGFINACDYDIEGSVIGYLIIKYLGDTKKAKRMKFSALTKSDILLAFRNVSTLDYDMINAGVARHKIDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVSSEIERNLFIPLPKFTVSVIVKIKDYSLNIKINKEFEKLAEANEFLNRLINKTVKVTQVENKIRILERPPPFNLTDLQVEAGRIYGISPYNVERIAEDLYLDGLISYPRTNSQKIPSTINIYNIIKGLENSSYRKLVNLVRKITGGKYIVRQGVKDDPAHPAIHPTGESPKNLPNNKFKIYDLIARRFLASVSADAKLSNTIYTLKVADFPLEFSVSYTKIPERNWLDIYHFHNVREDNPILLSKGDEGIISDGKVNISLSKPTSRYTKVSLLKWMESSDLGTEATRGRIIEILVKRRYLTSNGRYIVPTKLGFYIAELLNKFFPDIVDVRMTADMENKLEMIKTGKILESEVIKENIEKLNKFIEEYKANKDRVGESLAKALGLIKIVKCKFCDLEQYKDGLCKYHYEAKTKLLDAVRIWEERTKYDHKKILKRISSSKSTGKYVKDIVTYMLNMNDESHANLKR
(983) DNA topoisomerase 1 [Ureaplasma parvum serovar 3 str. ATCC 700970]
3
MQKDLIVVESPNKIKSIQSYLGDSYNVIATCGHLRELAKKSGYDPKTYDLKWEIIKTTNKKLSKKQQIKTIIDLAKKSNNIYLATDPDREGEAISWHVYDLLPKKDKERVKRITFNEITQKAILKSIDEKHDIDFNLVDSQFARRILDRVIGYKLSGLVKKNLHGLSAGRVQSIALLFVVERELERRSFVKEEWYQIEGIIEKNIFVSLRKIPYDVELYNQKDNSDSDLKFLHKKDAQRVIDDLSDIFKVYSIDDLKITKGDVQLPLTTDKLLQIASNNFGWSANKTTLIAQQMFEGLEINNQQLALITYPRTDSERLSDDFLQEANAFIENNFGKEYLENFKNKKINRKEVNIQDAHEAIRPVDINLKPEEIKDYVSLDIYKLYNLVWNKTLSALMKVPTFNKQVIRFINNEYKFYTAYKTIRTLGYWILDFYKKQRDELEFQPPIINVGDEFKKEKIDLIQKETTPPPYYTEASLIAALKNAGVGRPSTYATMATIGTTRGYINKDKSKLIPTELGIKVIQELKEAFPKVISIKFTSEMEERLDVIANGKLFWKDLVSTFIPIFEEEVKQAYTKIEKVPDEKINRLCPICAHDLLIKRSRMNTRFIACSNFPTCRFTESLEKPEILNELCPNCSKSLVKRKNRKNKYFIGCTGYPECNFIRNLDESNNDKNDFNQ
(1005) DNA topoisomerase 1 [Halomicrobium mukohataei DSM 12286]
3
MELIITEKENAARRIAEILSDGAATAERENGVNVYRWGTKRCMGLSGHVVGVDFPPEYSDWRDVEPAELVAADVVKSATQENIVATLRKLARRADEATIATDYDREGELIGKEAYELIREETDVPVDRVRFSSITDREVREAFANPDEIDFDLAAAGEARQVIDLVWGAALTRFLSLSARQLGDDFISVGRVQSPTLKLIVDREREIQAFDPEDYWEIFGDLQGDDAAFEAQYFYDDDGSEAERVWDEATAESVYEDLAALDAATVTSVRERTRTDAPPEPFNTTAFISAAGSLGYSAQRAMSLAEELYTAGYMTYPRTDNTVYPEDLEPDELLDEFVGSSTFGEDAESLLEQDEIVPTEGDEETTDHPPIHPTGELPPRGELDDDEWEIYELVVRRFFATVAEPAKWAHLRVVAEAAGHSLKANGKRLLEPGYHAVYPYSSASENVVPAVSEGDALTMSDVSLDAKQTQPPRRYGQSRLIKKMEDFGLGTKSTRHNTIEKLYDRGYIEGDPPRPTTLAEAVVEAAEEFADRIVSEEMTAQMEADMSAIASGEATLDEVTAESREMLDRVFEELADSREEVGDYLQESLKADKTLGPCPECGEDLLVRRSRQGSYFVGCDGFPECRFTLPLPSTGEPQVLDDSCEDHGLNHVKMLAGRDTFVHGCPRCEAEKADETDDEVIGACPECGEGAAPEEQRGEGGDSEAQSASDHSSGQSPREETAEAHGGKLAIKRLRSGSRLVGCTRYPDCEYSLPLPRNGDIVVGEDRCAEHDLPEISIVDDEDDDDPWELGCPICNYAEYQARNAIDDLEDLNGIGGATAEKLAAVGIDEPADLRAVEPDEIAANVQGVSASQIEDWQAELAD
(1008) DNA topoisomerase 1 [Mus musculus]
3
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKERRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRLRDEDDADYKPKKIKTEDIKKEKKRKSEEEEDGKLKKPKNKDKDKKVAEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
(1009) DNA topoisomerase 1 [Mus musculus]
3
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKERRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRLRDEDDADYKPKKIKTEDIKKEKKRKSEEEEDGKLKKPKNKDKDKKVAEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
(1010) DNA topoisomerase 1 [Mus musculus]
3
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKERRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRLRDEDDADYKPKKIKTEDIKKEKKRKSEEEEDGKLKKPKNKDKDKKVAEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
(1011) DNA topoisomerase 1 [Mus musculus]
3
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKERRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRLRDEDDADYKPKKIKTEDIKKEKKRKSEEEEDGKLKKPKNKDKDKKVAEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
(1022) DNA topoisomerase 1 [Haloterrigena turkmenica DSM 5511]
3
MELIITEKDNAARRIADILSGGTYDSSRENGVNVYEWGGKRCVGLSGHVVGVDFPDEYSDWRDVEPVELIDASVEKTATKENIVATLRILARKATRVTIATDYDREGELIGKEAYDIVRDVDEEVPIRRVRFSSITENEVQSAFDDPDDLDFDLAAAGEARQIIDLVWGAALTRFLSLSAGQLGNDFISVGRVQSPTLKLIVDREREIQAFDPETYWELFGDLTKEDTTFEAQYFYRDEDDNEAERVWEEAVADEVYETLAERDSATVVDVNRRTRTDTPPEPFNTTQFIRAAGAIGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPEELLDDFVSHPTLGESAESLLEADEIVPTEGDEETTDHPPIHPTGEIPSRGGDVSDDEWEVYELVVRRFYATVADAAVWEHLKVVTEVDDYRMKSNGKRLVEPGYHDVYPYFSTSENYVPDVTEGEELALTDVELEEKETQPPRRYGQSRLIETMEDMGIGTKSTRHNTLEKLYDRGYIESDPPRPTKLAMAVVDAAENYADRVVSEEMTAQLEQDMDAIASGEATLDDVTDESREMLEEIFANLADSRDEIGDHLRKSLKDDKRLGPCPECGEDLLVRRSRHGSYFVGCDGYPDCENTLPLPSTGKPLILESECEDHGLNEVKMLAGRQTFVHGCPLCKAEDAGEGPVLGTCPECGDEHDGELAVKTLQSGSRLVGCTRYPDCEYSLPLPRRGEIEVTDERCDEHGLPELVVHSGDDPWELGCPICNYQEFQARESDSGSDLEALDGVGAKTVEKLADAGIESLDDLTEADPDAVAEDVDGVSADRVRTWQAKA
(1031) DNA topoisomerase 1A [Leishmania donovani BPK282A1]
3
MLRRSVRALEKLVIVESPNKVIKVEGLLSDPKVIPDWSFNNSKLRAISTGAEKAIAMATTGHFMSLKELTWSPQSSSPASRVTAADFPSNGLLVSFSLEWELIPGRRIQDTVSHYIEEKADNLTEIIVATDPDREGELIAVHAQNLIRSMFPQLNVPFTRAYMHSITAEGIRRAMEERHETFDYNLANAAEARHAMDRIFGFLGSSVVRYANPQMRSIGRVQTPALILIKDREDKIKSYLDSHASTFEIQAVCYFTSKQNHRFSQVVKVTPAHKGGAAPVDWSDEATVKQRCEQWALSSATHFSVSPGAKPQETVTPPPKPFTMATLIARANRQLHYSSDMVSLCLQDLFQMGYITYPRTDSTRIDESILPSIYAAVRREHGKRLLQEQDGPPKSGSRRSTAQKEAADANVEDAHEAIRPTNIDTTVEELGAVSAPMKHIYDLVRRNTMAVHMIPMKTERIVVLVACKAANGEEVEFELQGKHVVEPGWSAAFRGSKGTATPVTETDQDMEAVEDGGVVVPSISDDEFKAIMDFAAQRGGGTGVKKGSMQLESAQVAENRPSPPLPFSEGGLIEQLKNNGVGRPSTYPMIVKTLLARNYITVKKGRCETTPVGRMLVDTSRATFPSIVDIGFTSAFEKKLDRIAKPGSAKEWALSPNVSDADYVLSSFISNFLNYVTEATKAHRVAITTRSLALQQEKRVASNTPMSPTDFQANLVKETKRVLTQVPDLVDNMKSYRTFTALQNSLNDYLRRNFPPSAAAVAPASSSGTARSYGSSSSSVKKKESHGAACKVDKKTPRRFRAKPKKPKK
(1045) DNA topoisomerase [Pyrobaculum arsenaticum DSM 13514]
3
MILIVAEKRSVAHAIAKFLGGRYKLEKIQGVAAYRFNYGGREAVALGLSGHLMDFDFTARQNVWTWIPPEELFASQPLIVYRPETMKYIRALRTLAARAHEVYLALDADVEGEAIAYEAALLVRLVNPRAKIYRVRFNAVTQREITNAFRNPTHINLRMVEKVFTRMQVDLTLGAVFTRFITLAVRHSLDRGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVVKALVEIGGHRIEMSADVRFKTRKEAEEAAATINRGVVKAAVYRPHHVNPPVPLETVELERRASRWLGINSKRTLDIAEELYRAGYISYPRTETTIYPPTLDLREVLQELASGHLGSYADELMRRGFRPTRGDSDDRAHPPIYPTRAATKGEVAKAFGKLAPQAWAIYDFVVRHFLATLSPPAVVEKQKIIVSFGKLEMEAEGQLVVDEGYWRIYPWERQSSKPLPRVSPGDPARAVKVDVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIHTNVRRGYMKITKGKCIPTDLGIALATSLFQFAPQLIEPTVRAKIEKALNSIVTDGTPPARLIYEIKKEFEEYYKALKARKEEIKKALETALNSSRNSQRG
(1048) DNA topoisomerase 1 [Methanocaldococcus sp. FS406-22]
3
MTALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERNGKKIIVASAVGHLFTLVEKENKEFGSYPVFDIKWVPASVEKGKEYVNKYIKALKKLSKEADEFYIATDWDIEGELIGYHALKYCCGKEKAKRMRFSSLTKKEIVKAFENPDEIDYGLVDAGESRHIVDWYFGINLSRALMNAIRAVNRWKTMSIGRVQGPALAFLTERELEIKKFVPKPYWVIEALFKDNLKAIHEKEKFWDEKEAKSVYEKIKNEKFGKVVEIKKTKRKIKPLPPFDLGTLQREAYSYFKISPKETQEIAQSLYEKGLCLHPDTLILLPDGIKKIKDLDDEGEVLCLNKDLKLTKSKYKLLKRTIKEKLIKITLNDGTELITTKEHPILVYRDELIFIPAEKLKENEQVVMFINNSEKTFKIKKTKFIDFILENKKYSHHYSIICTSDWKNKFKSGIAKKFDLSNQLSKNKGLSLDRLRKLSNYIIDRDLKRIANGDVYIQKIKKIEEIEYEGEVYDLTVKDYHNFIANGIVVHNCSYPRTSSQKLPKDRKYLEDILNIIKNHPVYGKWAERILKENLKPVEGKKEDPAHPAIHIVDIPKEELSEKEKKIYDLIARRTLAAFWDNAEREYLNVKVDIKGEKFKLSGSRTVKEGWHEIYYFPKFDEIELPALKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKKGLGTKATRAEIVDKLIKRGYVIDDGSLKVTDLGISVIETLKKFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVLEEAEKRLRKILEEFKKKEEDIGIYLIKNLDATNKKAKIVGKCPKCGGDLILIRHKKGRFVGCSNYPECDVKYSLPDKGRIKIPNKVCEACKSPILKIGDREVCINPECPLKQVEVKEDDRICPKCGAKLVLKKGIYGAFYGCSNYPKCKYTEPINKKEVVGKCPKCGGDLVVRDGKFGKFVGCSNYPKCKYTEKLKSNEKEK
(1074) DNA topoisomerase [Clostridium kluyveri DSM 555]
3
MKLILAEKPSLALNIVKSIGNMNRNDGYFENRDYLITFAYGHLLRLYDVDNYFKRGKTKWNLDELPFVPEDFKFKIREDKGVKKQYEVIKNLIRRNDVTEIVNCGDADREGEVIVNNIISRIFKEENINKPVKRLWLPEQTTQTIRQELRNLKDNRDYKNLYNEGLARTYLDWTYGINLTRYLSIKSQTFLPVGRVLIPIVKFIYDRDRAIENFKPETYFEIGAVIKKDNLEIKAKLKDRRFSADEREKAANLLNSLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKQFKMSLDDTLKHLQKLYECGFTTYPRTNTEYLAENEKGKIKSIIEVMKEKFNVDIDFKDKKKIFDNNKVESHSAITPTTKIPEIEKLSEDEKKVYTAIRNRFISNFLNEETIIEETYVIIRIVDEVIELKGNVIKQTGFLKYENIKKENELPDFVEDEKLDTKLSVDEKQTQKPNRVTESELNNFLKNPFKKKEIQDLENTNDDEEYKMILEGCEIGTVATRAVIIKNAQKYEYIKEVKGHFECENKGIRLIDVLKRLNIDLDKGKTVEFGKQLKGVYKNDIEINTIIYNVKSELNNIIRKGDEIKIDRIESKKYESMGVCPICGKGNIMANKFGYGCSRWREGCKFFIGKQIAGKNISESMAKKLIKNKKTNVIKGFKSKNGKSFDAVLTIKDENVAFDFSSESKGLGTCPVCGKGNVIANKSGYGCDKWKEGCKFFIGSKIASKSITESMVKKLLKDKKTNLIKGFKSKNGEVFDAFLIIKDSKIVFDFKE
(1080) Topoisomerase IA [Slackia heliotrinireducens DSM 20476]
3
MKLVVTEKNNAAQRIAELLGVKKPKSDKVYNTPVYRFERDGEEWVSIGLRGHILEPDFVPTITYKRNKGWLATPDDGASYKVDIPSFLPKPPFKTKRKPFLADGVAIGGSWKMDALPYLVYAPIQKNPKEKDIIRSLKNLAKKADDIIIATDFDREGELIGSDALSCIREVNTTAPVSRARYSALIKPEITHAFENLVELDMNLAHAGESRQEIDLIWGAVLTRYLTIVKFAGYGNVRSSGRVQTPTLALIVERERERMAFVPEDYWVIKAKFSDGIEPFEATHKEGRFKTQEAADAVMNAVNGAQFGTVSGIEKRKRTVSAPTPFNTTGLMAAAAAEGLSPARTMRLAESLYMAGYTSYPRVDNTVYPSSFDLPAMVKTLSEVPAYEPYCRQLLAKGTLTPTRGKQESTDHPPIVPMQAASPDKLQPAEWKLYNLIARRFLATLSDAAVIEGTKVSVDVNDETFITRGDVVVKPGFRAIYPYGAKKDTILPQLNEGQQVDFLGATCEQKQTEPPARYSQGKLIQEMEKLGLGTKATRHSIIDRLYNVKYIQNDPIEPSQLGIAVCDALGRFAPQITSPGMTAELEKDMNQIADGDKTQKEVVDLSRDILNDVLKELMPHSEEVASALGDAVAADAYVGTCPKCGKDLQMRASNKTKSMFIGCSGWPECDVTYPLPKGKVEVVEEKCPVCGMPQIKVTAFRSKPRVQCIDPNCDSNQEPDVIVGACKACAEKGLDKKLIAQRNPRTLKRFIRCENYEECGVSYPLPQHGELKATEEVCPDCGAPMVIVTTGRGPWKLCPNFDCPGKEKEEGAEDKKAPAKRTTRKTATKKTTRKTSK
(1083) DNA topoisomerase 1 [Mycoplasma suis KI3806]
3
MRELMFVESPAKIKSISKYLSGRNLKVFATYGHIRELSKGWLNFGPDNFEIKWSNIERKISYENKKVSIIEAIKNEAKQASKIYLSTDPDREGEAIAWHIYSILGKEHQKKCSRAVFNEITESAVKYSLENTRQLDQAQINSYLARVLLDRWIGFNLSSYVRKKVGGQSAGRVQSIALKFLADRDEEIKSFQPKNWFILKVQLQVGLTITLFKLSEAAESQVVLSPHGKKGVVSFQKKEDLERIINDHLDDHYILEEIGEKKLETSSPPEVLKTSTLFELAINKLGLKAEDVRRVAQSLYEGINLGGETISLITYPRTDRSSVSEEFLKLVKKFILKEYGETYWVEEGTLKKKSIMGKKEIFIQGAHEGIRPTDVELTPQKLSKLLSTSSLEFQLYRLIWSYTVASFFPSSRNEKRRYVFENQGNFFYASESSEVFDGYKYILRENGLLESREKSEFDFKQLIKNNKYLSKEDIIMEERNSPPSKYSEATLIKALENKGIGRPSTYPLISEIVRTRNYANFKNKKFEITELGYKVSKDLDQNFSNFISYDYTRTMEEELDNISKLKTDWKKFLEGVFIAWNDSLKGAEKAEIVKDKSCPECGSQCVYKFSRKNHNKFIGCIDFPKCKFVENIEQPQKEVELLDKLCSECKSPLAKKKNRWGNEFISCSNYPKCKYIERNKQEYETVENSFCPECNSQLVYKNSKRKGNKFIACSGFPNCRYSSTLEGKRIESKGNSKSNKPPEKLDRKCPKCKKNYLQIKMSRKGTKFISCSGYPRCKYVEWMDKEGETENKSS
(1088) DNA topoisomerase 1 [Methanotorris igneus Kol 5]
3
MVALIICEKPSVAKKIAEALGKPKKKSIYGVPYYELERNGKKILVASAVGHLFTLVEKKEGKFGEYPVFDIDWVPASIEEGKKYVENYIKALKKLSKEADEFYVATDWDIEGELIGYHALYYCCGKKNAKRMRFSSLTKKEIVKAFENPDTIDFGLVDAGDSRHKVDWYFGINVSRALMEAIRAVKRWKTMSTGRVQGPALAFLVERELEIKRFVPKPYWVISALLDEKLNATHEKEKFWDEKEANQVYKKIKDVKEGIVVEVKKRKKKIKPNPPFDLGTLQREAYRIYKFSPKKTQEIAQRLYEKSLCSYPRTSSQKLPKDKKYLEDVLSIIKNHPIYGKYAERILKENLKPIEGKKEDPAHPAIHIVDIPKEKLSEEEEKIYDLIARRTLAAFWDDAEREYCNITIDIGGEKFKLSGSRTVKEGWHEIYYFTKFDEIELPPLKKNEKIKVEKINIERKETKPPKRYTVASIIKELESRKLGTKCLTPNTLIKVEIDNIIKYIKIENLFELLNDRFKDGNVEFAINNKNIKCFSYDTDEIKSIFKYISKRKLEKNESVYKIEFEDGSFIEVTEEHPILIYDGDGEFKYIRAKDLKKGMKTISSIKYDDKEGDVICTWEKFIEICNEKSKLYGISEDIGKIREKLGMSKYKFAKKYGLSCSSVWKYEKNKRIPIYLFKKLDLKKPNYIASTNKNVIIKNPFPLKISSSLVRILAHLIGDGSIDKEKIKRENCYDFRYHNTNIDLIKQFVEDIERVFGIKLTIKKAKKRKNQKLKYYVQVPSVVGRIISILFKEVIEKNAPKIPKEFYPEFIGALFDDEGCAIEKEGKAFISNTNLELLKDVKEMLLELGIKSRIDEKQFKLFIKGRKNIQKFLNIIPFISVDKKQKLINALSNKYKWKDCSVVKKEKEIIKVLGLYGAIDLNELSKKTKLPASVVREYIKEFIKNGIVEEIVSDNKKIVYTLKIPPHKTFYRYIGEKVINKDFITKTISNIKKINYNGYVYDIINSEYSNFIANNIVVHNSTRAEIIDKLISRGYVVDDGSLRVTDLGIAVIETLKKFCPEIIDEKMTRDLEEKLELIQSGKIKKEDVLKEAEEKLREILKKFKEKEKEIGKELVSKIDSTNKKLKTIGKCKCGGDLVIIRTKDKKRFVGCTNYPECNITYSLPKKGRIKVLNETCESCGLPVIGIDGQKLCINPECPSKMPKENIEDLKESINNGKKICPKCGGKLVIKNGIYGAFLGCENYPKCKYTEKIKKNNGEVVGKCPKCGGDLVKKNGKYGEFIGCSNYPKCRYTEKFKK
(1094) DNA topoisomerase 1 [Cricetulus griseus]
3
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKIRASGDAKIKKEKENGFSSPPRIKDEPDDDGYFAPPKEDIKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKLEEEEDGKLKKTKNKDKDKKGAESDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNVITNLSKCDFTQMSQYFKDQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVSCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
(1095) DNA topoisomerase 1 [Cricetulus griseus]
3
MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKEKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKIRASGDAKIKKEKENGFSSPPRIKDEPDDDGYFAPPKEDIKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKLEEEEDGKLKKTKNKDKDKKGAESDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPEGVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNVITNLSKCDFTQMSQYFKDQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVSCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
(1096) DNA topoisomerase [Gallionella capsiferriformans ES-2]
3
MKQAVKVTTNHSARNTFYLCEKPSQARTLAKVLGAEKGRDQMHFAEGVVIGHAYGHMLNLAKPETYIGTGPWCLDNLPILPKTWLWQVKDEHREHLDNLGKYLSQADLVVLATDPDEEGEVIGRQILQTHNYSGEALRLWMSALETESLKKSLQNLRPLSETDHFYQAGRVRHEMDWLFGMNLSRAFSVLLKSKANIGRVKTRLLNEIVTNDQQAENVIQDGYETAYVMLGDTLLELIQADQPCDHIVNFKKLAGAQCGIYRNDKSCNYTDEMGVPLVTPRPLPYTLTALLADSADIGIPLDEGYKAVQKLYESGAISYPRTNSTKLPGTSSDDFAVHHAIVAMRDDLPAGMTEEATRIFELIRLNELYQRNQLITIDRTQTIEIGGEYFASREEWKTISFDSPDRALLKNQNILANQKKLAIYKTGDEFPVKVRLTRENYGKPTYFTESSLLRMMAEKGIGTESTRVAAITNLIKEKLIDVTPQTDHEGVPSTQARTIRSTKLGRDLISRLPEVVTGQEMEAQLQEALKDMRVGQSDESTHLKHTGAWLTKTIREAA
(1109) DNA topoisomerase III [Azospirillum lipoferum 4B]
3
MATLIITEKSSQAKDLRAALGDRYGRILPAEGHLLRLAEPDEVDPAWKRWSPTLLKPDGLYPTRPDQGGNKAAKLQAITAALRACDEVILATDCDREGQLIGQEILEHVGYRGKVRRALFTAQDPKTLRDAFSALKPNDSMRPLYEAAVARQQADQIYNLSLTRTATKTLLAPGTRGVIGIGRVKTPTLAIVCLRELEIRNFKPEDYFEVVATASVAEGSFQMRHAPAPKDRIKDRATAEAIARAADNHRGPLTVTVEEKRQVPPKLYDLPALQKTCGQRWGWTADRTLAVAQELYDGDGKKLITYPRAEARYLSENQIADVPAIVGALTRLRGFAHLDIARPVIRKGKSGHFCDKALEGVSHHAVIPNVNVLDDLESRLVRLTDDEKRLYALICRSYLAAVMPDYEYRQTSVTMPVPMPTPGGTKPVAFRAVGRIPLKLGWKAAFGSAESDDRSGGKPEEEAEQTLPPLTDGEPATLSDPKLEAKRTQAPPRYNEGTLVDAMQNAWRFVEEPSLRDRLKEAKGIGTPATRAEVIKGLRKQNLLGADGKWLVPTPAGLHLFETLRAAAPTLVDPGTTALWEMKLDDVVTGRADFRRVIDAIATEAERLIGALVGQRGTLLDLGMPAPKARFARRGTGGRTTGAAAGAAKPVRRRTRKAEAPVEGGAAAPKPRRVRKAKAPASAPPTSAQADNGRPAAPATAPAPPNGLRRREPTERMVAFARSLAERKGIDLPDPCLRDFDQCRSFLDQHAR
(1110) DNA topoisomerase 1 [Halorubrum lacusprofundi ATCC 49239]
3
MSRGPELIITEKDNAARRIADILSGESATAERENDVNVYKWGGKRCIGLSGHVVGVDFPAEYNDWRDVEPVELIDAPITKEPTQEGIVAALRKLARNASRVVIATDYDREGELIGKEAYELVREVNEDAPIDRVRFSSITDNEVNEAFANPDELDFDLAAAGEARQVIDLTWGAALTRFLSLSARQLGEDFISVGRVQGPTLKLIVDREREIKAFDPEAYWELYGNLTKSGGDPFEARYFYLNDEGNEAERVWNGDVAEVLTEAFDAADEAVVDDVRRRTRTDDPPTPFNTTAFIRAAGSLGHSAQRAMSLAEDLYTAGYVTYPRTDNTVYPEDLDPRELIEELSVASTFGKDAKSLLEQEEIEPTEGDEETTDHPPIHPTGELPSASDLSEDEWEVYELIVRRFLATCAEPATWERLRVVALANDEATAIAERADGLAALRNPEEASGPGDLVADGGLRLKANGKRLLEAGYHDVYPYRSSDERIVPDVEVGETLALTDRRTDAKETQPPRRYGQSRLIEEMEKRGVGTKATRHRTLEKLYDRNYIESDPPRPTRLAEAVVEAAEEFAEHVVSEEMTAQLERDMQAIAAGEKGYDEVTEASRELLNRVFDDLTESREAVGDHLQKSLKADKTLGPCPECGSDLLVRKSRQGSYFVGCDGYPDCEYTLPLPSSGKPLLLDETCEEHELRHVKMLAGRKTFVHGCPQCKADEADEQEDEVIGACPECGEEHGGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGEIEVTDEICEEHGLPHLRVHSGDEPWELGCPICNYREFTARQEGSELQTVEGIGEKTAEKLKDAGVDGVDDLKSIDPDELAADVDGVGADTVRDWQAKAD
(1119) DNA topoisomerase 1 [Methanospirillum hungatei JF-1]
3
MHLIIAEKNIAANRIAQILSGKDKVSAKKEGGVNVYTFGDKISIGLRGHVVEVDFVEGYTNWRSQERPPRSLIDAETIKRPTEPAIVKLIHKIAKKANRVTIATDFDTEGELIGKEAYELVRAVNPKVPIDRARFSAITKEEINRAFSEPSDLDFDLAAAGEARQVVDLIWGASLTRFISLAAKRGGGNILSVGRVQSPTLAMIVDREKEIESFIPEPYWEISLTTEKDGQSIIARHAEGRFTDKKLADAAYAGTKDPLVVTEVKEGKRVDRAPTPFDTTQFIVAAARIGYSAANAMRVAEELYMNGFISYPRTDNTIYPPSLNLDNILTTLEKTKFARDVAWVRKNRRTKPTEGKKSSTDHPPIHPTGVATEEQLGENWKLYELVVRRFLATLSPDAEWATMRIGMDATGQNYVATGSRLTEAGWRTVYPYSEAKDSILPVVKKGEKLKIQDLNLEEKQTQPPPRYSQSKLIQVMEELGLGTKSTRHEVIQKLISRKYIEGNPLRPTLVGKAVTESLEAHASTITRPDMTQKLEQAMEAIKVRNKSRDGVVDDSRKMLHQVFDELEPNEAVIGQEIMGQTDEELTIGPCPVCGKDLRIRRKGGSQFIGCNGYPDCTCNISLPGTMWGSAVRTKKVCEVHNLFHVSLIAKGARPWEMGCPLCQLIEQQKEHYAKMPAMTEALQQKLLDAKIFSLYELSKLEPAVLAKKLGITKKQAETLIHEANDVLDLIRRRSECKKFMKQFVPPKRGRSHTKVMNGFTESGINCIGDIASATIESLKKTGLSEEEAKTLKSEAISLIAKNQLKDIGIPAVSLKRYQEAGFLTPEDIASAHPAYLAFKTGISIETVGKHATLITQSLGKPDPVKISKKAFESGKIELTSLPGVGESTLEHLYRAGIFDKKSLISADPAKVAKSGGLSKDHLKKLQAAAVV
(1128) DNA topoisomerase [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
3
MTTVILAEKPSQARAYAVAFTQSQKGEGQIKVADPILPADTVITYGFGHLVEMALPEAYDASYKRWSLKKLPIFPDQYKYLVSRDKKKQFNIVANLLKRADTIVIATDSDREGENIAWSIMRQAGIDLKQKHLFRLWINSLEKAAIREGFQNLRPGWDYYYRYKEAQTRQISDWLVGMNGSPLFTLLLRKQGIKGTYSIGRVQTPTLYMVYKRDQEIANFKPEKYWLLMADFWQGRKKFTGRLLPETKFKSPAELEQFLLAKGGSLGKQTGRVAKVDKEQKSQASPRLFSLSSLQTEANRRYHASASQVLQAVQNLYENKFLSYPRTDCNYITDNEYAYLAQNLDRYQGLLPNSAEVKEQMKPLKAEKRYVDSGKVQEHHAIIMTKTVPSQAQMGKMSKLEGQVYGLVLRRTLEMFLKAYVYEKTTALINVGQLTFKASGNVSVNLGWKILEGPVKDAQLPSLEVGQELTAKLKEQEEETKPPAKFTEGSLITAMKTAGKTLDDEDAQATLKDVEGIGTEATRASTIEILKKRGYMQSRQNKLSVTPEGTILCKVAEAEPLLVSAQMTAQWEKALKQVGAKERSQDNFLGQIKKFISKMITEVPGKIQVDQGLQEEAQTRQAKTAAIGPCPVCKQGEITDKGKFYGCSNYRGGCHFTLPKKFAGKNMGKRIVKTLISKGKTDKLDGFISKKSGQRYSAKLQLEGDKLSLVFD
(1130) DNA topoisomerase 1 [Aciduliprofundum boonei T469]
3
MNILVIAEKRNAAQRIAKILSGGRYETIKKGRNAYYSFTKGKDRYFVVPLRGHILHMDYPDKFKRWSLGDLQRLVDEEPIKIIKEKGIANILRTLAKDADMLIIATDYDREGELIGVESLSITNFKGPVKRAKFSALTEREIENAFSNLVDVNYNLASAAETRQKIDLAWGASLTRFISLASSRRGKDYLSVGRVQSPTLALIVKREKEIENFVPTPYWNIKGLFFKRRNFSGMHISNPFWKEEEVMEVYEKVKDTKSAKVLDFVQEDRKIRPPIPFNTTEFLSEATKLGFSAAKAMRLAEELYMGGYISYPRTDNTVYPKTLSINSILKSLEKSKFKEEALKLQKERRRYPTRGKKESTDHPPIVPTRGANLEGDKGKIYELVVRRFMATLAQDLEYRESKVKLAVKDEIFEAKGKELVNEGWLYYYPYVRFEEEKIPILRIGDEVKVKKIEIERKETRPPARYTQSSLIREMEKLNLGTKSTRAEIIQKLFERGYVRGNPIRPTQLGKALIESLEGNNVDVIKPDMTARLEMDMDEIEKGSKAPEFVVKESREMLKKILSSLEENRSTVGSNIKSSMRREIGECPDGGKLIYLERKRLVVCENDGETKYYNLPKTGHIEFLDKKCPICGLPLIKIIRRGQSPEIRCLNSKCEYNRKKDIVGKCPKCGGDLVIRQSKNGKRFIGCSNYPKCDVTYSLPQRGKIIPTGEVCPYCGAPLLILRKKGKKDWKFCPNIKCEYNRRNKDEK
(1131) DNA topoisomerase 1 [Aciduliprofundum boonei T469]
3
MNILVIAEKRNAAQRIAKILSGGRYETIKKGRNAYYSFTKGKDRYFVVPLRGHILHMDYPDKFKRWSLGDLQRLVDEEPIKIIKEKGIANILRTLAKDADMLIIATDYDREGELIGVESLSITNFKGPVKRAKFSALTEREIENAFSNLVDVNYNLASAAETRQKIDLAWGASLTRFISLASSRRGKDYLSVGRVQSPTLALIVKREKEIENFVPTPYWNIKGLFFKRRNFSGMHISNPFWKEEEVMEVYEKVKDTKSAKVLDFVQEDRKIRPPIPFNTTEFLSEATKLGFSAAKAMRLAEELYMGGYISYPRTDNTVYPKTLSINSILKSLEKSKFKEEALKLQKERRRYPTRGKKESTDHPPIVPTRGANLEGDKGKIYELVVRRFMATLAQDLEYRESKVKLAVKDEIFEAKGKELVNEGWLYYYPYVRFEEEKIPILRIGDEVKVKKIEIERKETRPPARYTQSSLIREMEKLNLGTKSTRAEIIQKLFERGYVRGNPIRPTQLGKALIESLEGNNVDVIKPDMTARLEMDMDEIEKGSKAPEFVVKESREMLKKILSSLEENRSTVGSNIKSSMRREIGECPDGGKLIYLERKRLVVCENDGETKYYNLPKTGHIEFLDKKCPICGLPLIKIIRRGQSPEIRCLNSKCEYNRKKDIVGKCPKCGGDLVIRQSKNGKRFIGCSNYPKCDVTYSLPQRGKIIPTGEVCPYCGAPLLILRKKGKKDWKFCPNIKCEYNRRNKDEK
(1132) DNA topoisomerase III [Azospirillum sp. B510]
3
MATLIITEKSSQAKDLRAALGDRFGRILPAEGHLLRLAEPDEVDPAWKRWSPTLLKPDGLYPTRPDQGGNKAAKLQAITTALRACDEVILATDCDREGQLIGQEILEHVGYRGKVRRALFTAQDPKTLRDAFAALKPNDSMRPLYEAAVARQQADQIYNLSLTRTATKTLLAPGTRGVIGIGRVKTPTLAIVCLRELEIRDFKPEDYFEVVATANVAEGRFLMRHAPAPKDRIKDRATAEAIARAADQHRGPLTVTVEEKRQAPPRLYDLPSLQKTCGQRWGWTADRTLAVAQELYDGDGKKLITYPRAEARYLSENQIGDAPAIVGALTRLRGFAHLGEHMDVRRPVIRKGKSGHFCDKALEGVSHHAVIPNVNVLDDLESRLGRLSDDEKRLFALICRSYLAAVMPDYEYRQTGVTMPVPVPPPEGARTEGAKPVAFRAVGRIPLKLGWKAAFGSAETEDRSGGKPEEEAEQTLPPLRDGEPATLTDPKVEAKRTQAPPRYNEGTLVDAMQNAWRFVEDPALRDRLKEAKGIGTPATRAEVIKGLRKQNLLGADGKWLVPTPAGLHLFETLRAAAPTLVDPGTTALWEMKLDEVVTGRADFRGVIDAIAGEADRLIGALLGQRGTMLDLGQPAAKTRFTRRRTGATRAASAQTGAPAAPKGRRTRKATVVPADGAAMPPKPRRTRKAKEAAVAPPVTGSAVAQPMESQAGPEARRRREPTERMVAFARSLAERKGIALPDPCLRDFERCRSFLDEHAR
(1147) DNA topoisomerase 1 [Pyrococcus sp. NA2]
3
MILVIAEKPNVARKIAGALAEGRPIKRTMFGVPFYELFRDGKKVIVAPAVGHLYGLAPKQDFYGYPIFEIEWVPVYMAEKGKEYAKDYINLLSVLSRRVREFIVACDYDTEGEVIGYTALKYACKVDPKIAKRMKFSTLTKGDLIRAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWIILSTGRVQGPTLKFLVDREREIQSFVPKPYWVIKMVIEKGGKKLVATYEKDKVFDEAEAKRIVEETRKGKAIVEKVEVKRQNRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQSLYEKGYCLHPDSLILTPSGIKKIRELPEKGEVLALDFNLKLSKAKYRLLERDADEPMYRIILSDGTELYLTGDHPVLTYREGRLIFIPAEKLKENDKVVLLNGGYKDTYSLSFLLEEASMDDYIIYEKSFGEVIKTRMTNEMKEIYSYLNGKIPIPVLRFLIEKKIVSEEEIFKVFRGFSYLDSQLPINDRFWHLIGMIIAIGYKLENDNVILLPSKEITNRVIEHVEALGIPFVYDGERLVLKSKSLSRLLKIIGDKVIPPKKDWMISLIKGYQEVNGLRFRDKELAYKLKVMFQLLGVRTRLKRGTTYELVIDSEHEPEVEEGPDAPRVANGDVYILEIKSIDKFHYRGKVYDLVVEDYHNFIANGVIVHNCSYPRTSSQKLPKNLNFRFIIQNIARMPEYRPIAHELLGKEVLKPVEGKKEDPAHPAIYPTGEIPEPGELTRDEWNLYDLIVRRFLALFMEPAVRESMKVIINANGHRYILSGARTVKEGWLRAYGKYIKFDEVILPLFFRGERVRVLQVRRERKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVVETLEKYVPEIVSVELTREFEEKMELIMQGKLTKEEVIEEAKERLTKILQKFKEKELEIGIELAKIVVGEDVKLPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQKGEIIPTNKTCCNGAPVVIIREEDGREIEICLDMNCKWPKSY
(1151) DNA topoisomerase 3 (DNA topoisomerase III) [Campylobacter hominis ATCC BAA-381]
3
MKLFIAEKPALAKSIAAGIDGEYKNGDGFFQKGENIITWAFGHLLELYMPEDYDENFKKWDLKDLPLKIDEFKYKPIQSSKEQLKIICNLIKRSDVDTIINCGDADEEGQILIDEILKYANNKKPVLRLLLHDLTEKGVRSELKNMKSNNDFSNLSECGFARSIADWIVGINLTRAYTTKAQNNGYKGVISVGRVQTPILGLVVSRDLEREGHKSSFYYTLTGKFKTHQAEILANLKTDEKITDENEANEIKNICLGKNGILNVTNENKLEYPPLPYNLLNLQADCSKKFNFKPDKTLKITQDLREKYKCITYNRSDCEYLPVNMWESSTNVLNSIKSNLSDFENIIKNADPNLKSRAFNDEFITAHFAIIPTETTFDFNSMSKDEQNVYKLISKRYIAQFYEPMQYLQTNIEILINDYKFTTSKKKITKNGYLSLFSGENDSEQKNDDEVENSFDLSLLESGNCQTLNIEINKKQTKPKPYYTMPTLLKDLTSISKYVKDEKIKTLLKEKDKDKKGENGGIGTPATRSEHIKNLFEREYIREEKKSIISTKKGRDLIALAPKILSTPDMTALWYEQQLEIQNGNLSKDDFLNRVFDEVEEQIELIKNNALLDKNFNGIDKTYPCKCGKGFLQKRHSQKTGKDFWGCSNWKNGCSEIYPDLNGKPNIPKYFCPKCGSALNRWKNKKGDGYYWSCSGWKTKGCQIGFINDKNGKPEI
(1152) DNA topoisomerase [Clostridium perfringens str. 13]
3
MKKLVIAEKPSLAMNIVKALNSSESFERKDGYFESENYIISFAFGHLFKLYNIEEYTGEDKGAKWRNDILPFIPKEFKFSIKDDVGVKKQYKILEELIKSNRVDEIVACGDADREGEVIIRLIINNVFNNNSINKKVTRLWLPEQTTQSILYGLNNLKDIDTYNNLANEGFTRTFLDWLVGVNLTRYVTVKSKHLFPVGRVLVPIVQAIYERDKSIENFVPETYYQIESNEKTNDEIIKLVVKELAFTKSEFIKAKSFADELNTYEAIVISKDTKKVKKQPSKLFSLSKLQSLLSKKYKMTFKESLELIQKLYEKGFVTYPRTNTEYLAEAEKGKVKEIIDILCSEGYNLEFKDKKTIFDDSKIESHSAITPTVKIPKEDELKGKMLDVYNTIKNRFISNFLIEETLIDRTIIRIEVGDLEFSLKGDVIVQKGFLEYEPIKKDENTLPNLNVGDKINTNFKAIEKVTQAPGKMTTEMLSNYLKNPFKNYEIENEEEDYKAILDGLEIGTEATRTGIIENAKKYKYISENKSVLSIEPLGRKLIETLDKLNVNLSKEKTVEFSRILKKVYKNELNIDRAVDLISNELKSILEDSKNIEIEAIKEEKEVIGKCPRCGKNIYETSKSFSCEGYKDEPKCQFNIWKEDKFFKDKGKKVTKSIAKNLLAGKKVKMTGLKKKDGNGTYDAFVSLNDTGKYVNYKLDFSK
(1154) DNA topoisomerase 1 [Nostoc sp. PCC 7120]
3
MPKRLLVVESPGKVKKLSQILGSEWIVRASCGHIRELSDEGEDALGFSMDGSSVQCHYVPRDQRSKETIQQLKSAAKQVSEVVLGTDPDREGETIAWHLKEVLGLREPKRVVYTEITASAVQSAIAHPRKLDLNLVGAGLCRDCLDKLVGYKGSPLVWALNNGAKSVGRVQSSTLHLICQREREIQSFVPQDYWSVWVDYVEGFRAFYKGAVNTRSNSPEAEVEIHDDAAGNSTTAPESTRVLAEAEANRLVEEARRHPHQIVQYEGKVANRQPPPPFITSTLQQAAGSKLKFAPEKTMQLAQKLYEAGLITYMRTDSVMLSPEFCESARQWLEQNDPQNVPTQVARHRSSKTAQQGHEAIRPTDVFRPSAQLRIELSTDEFNLYVMIWKRAIASQCRPAQLRKTVVITQSGQILWQARGQVVEFLGYTRYWPNLSKDTLLPTLQQGQMVTLENAGHEKKQTQPPPRYSEPKLVQLMERKGIGRPSTYSPTIATLKKRGYVELTKDNLHPTNLGLEVDTFLQKALPDLLEAEFTAKMENALDAIAEGKQPWQIYLTTWNQNYFAPALAKAKTVTVDSGKTTKTFPARQYDTSRTRCPDCNNFLSKIPSSKLKKKYFLKCTSGCENTVLFWSEFSKTWQAPRTKDDKMAENGEKNHLSPSTKLPTQLTAYPCPVCKKPLEEYTYTKDGQKKTMLRCSASSSRTDKKHKDVAYFHTAKGWWSPKFGEIT
(1158) DNA topoisomerase I [Helicobacter bizzozeronii CIII-1]
3
MQKPDVIIIESPNKIKKIASITGAKVLATIGHFMELEGIEGENFKPKFAYRADKKQQIYAMIEQCKGKRVYIATDPDREGYAIGKMFYEKIKNVAKEVFRAEFHEITESGINKGLQSALLFANTNSNHYESFLARSVSDHYIGFTLSPYLGDCLQQRKGNSVGRVQTPCLKLIVDRDKEIEAFKALPESQKVSYQIQAKIYDTHNREVILRHCNGEGKEIKYESQEQALAMLAPLKECKVALVLDIKHFTISSPPPKPFITSSLLKVGSTQLGLSTQQIQEHAQKLFEAGLITYIRTDAETLSQEFLYKAEKFYQPIYTNLYERRAYKAKNSQAEAHEAIRITHCHKFEDTQDILAQAGIADNQAQALYTLIFQRTLESQGKSAVYAKQDLQFKIKDHFFKCSVRSLKQAGYLDMFRHTEQAKSAEQAENEQNAHLDLKTDSTISLLSLDIAPIQKHAKSAYVEASFIEVLEKNGIGRPSTYASYLPKLTQREYIQITPDKKRIVNATHKGKQVISVFEASPYSWIVDTQFTALMEELLDKIVRQECSYVEYMQMIAQRCPQMPSQTPREEYPTRAPRESQVKYVQDILRDLKMELPSEFADYARDDKITKAFLDKFIPKHKEAREKAKQEGHYLGDNTPASKPATAKQVAFAESLSQKHNVKLPKDYKSNMQVCSGFIEEWKGK
(1165) Putative DNA topoisomerase III [Leishmania mexicana MHOM/GT/2001/U1103]
3
MGRNVLMVAEKPSLAESIATILSNGSCSRRTRALPVYEYMGNFMGSPAYFKVTSTTGHVFSCDFTSQHQNWDRTDEEQLFTAPITWKDTSGKVTHHLEHEAQGCDTLVLWLDCDREGENICFEVMQVVRREIYNHNNIFRAHFSAITAEEIFHAFRNLGKPNKNVSDAVTCRQELDLKVGVAFTRFQTKYFQGKYGDLDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVATRGGALLQFEWDRGRLFDETMARLILQRITKNGKVATVANVSVSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAENLYIRGYISYPRTESTAYPPSFNLAGTLAQQKNHSMWGAYVTALLQQGHARPKAGKDAGDHPPITPMRSASPGELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGEFFSISGKVVEDPGFTEIMPHARVEDDRMPTGINKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKNGIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEEYVTHIAEGRAQLDDVLSYSLDLFFSKFKFFKEHIDVFDALMGASFSAISATGKPITRCGNCMRYLKHLDTRPQRLYCPYCEVTFALPQGGAIKQYSSFKCPIDNFELVICHIEGGKSFPICPQCYNNPPFEDMRPAIQHHHRGYGGGAAATTAPSTRHMACDECRHPTCEHSLATNYVCDCVDGSCAGSMAFVPRTAGQWKVCCNKCPMMIKLPPTAQRVYVTSEECLECAANCLDIMFPEGKSVLPNRKDRIVACIFCHPGLSPLCEEVRGRIGNFRRIGGAAAGGRGGRGGRGRGRGRGRGNREDRR
(1168) DNA topoisomerase [Clostridium beijerinckii NCIMB 8052]
3
MAKVIIAEKPSVAKNIADAFNVKTRRDGYFEGNGYYITWAFGHLLQLYDAKDYDENMKGWRFEKFPFIPEHFLYKVKCDSVDRTVEDKGAKKQLGIIKSLIDKEDVDGIVSATDFDREGQVIADELFGYFKVKKPIYRLLLNEWTPDEVKSGMESLKDNKEMQPLQDAGIGRQWSDWIIGINLTSVSTLKYKFEENKTINIGRVLLPTLKIIYDRDKEIENFTATTYYKLVSNFKTSANEEFEGLYYENDSEKFEKKEDLDKFISRLEGATAKIIDKQTELKKEYPPYLFNLSNLQGHITSKYKGWTSDKVLKVAQSLYEKKLTTYPRTASVVLEESLKDRAKKVLNTLKAGLPYEKDIKFSTSKRIFDSSKVESHSAITPTYIKPSGLSSDEKIVYDAIKNRFIMQFMPIAEFEETKVTLKANVSEMNGIFVSKGKVKLVEGWKVVEKIESKDVILPKIEIDETVDIVDSKVNSVTKKPPKYHTEKTLLRVMETCGKGIEGKDEDSEEMMQAILSGFSIGTPATRAETIKKLKDIGYLKTKGKNLMCTELGRNLVETFPVKELFDLEYTGRLEKTLSDIEKGKFAKSEFIKLITDFTIQSVELIKKDDAALSRFKVEIPKDSENIGPCPVCGNPVIEGEKSFGCSNWKNGCKYTIWKDDRYIASFGKKISKEMVELLLKNGKVGFRNLKSKKGNTFSAYFKYEKNEESGYFNWKIEFIDNK
(1184) DNA topoisomerase 1 [Mycoplasma capricolum subsp. capricolum ATCC 27343]
3
MKVLVLLESPSKIEKIKHYLEESFPENEFVVLASGGHINSIADKGAWGLGIDLETMQPNFVIESSRKKIISQIKKEGKTADLIILASDPDREGEAIAYHLANLFKDHTNIKRITFNEITSEAITNAFNNLRDIDMNLVNAQISRQILDKIIGYLVSKSLQKSTGLMSAGRVQTPALNILTTRDTLIKNFKEVLYKKIFVIESKRAINLNLNKDKNNVLVNTEKTYYIDENQAKTIVDELGEIYRCTDYKSTAYETRSFKPYSTAGLLQDGFTKLKLSTSQITLAAQKLYELGYITYIRTDSVKYSSQFIGEVKDYISKNYSSDLFKDPIVGKKDQNSQEAHESIRPTNIWLTPEKASLEIEDNLLKRVYNLIWWNSIKSLMKGPSGFNHRWTFNNNGYEFKQSWQEVKDLGYQAIKHSSSDENIELTDDGEEIVQSKNDKPEYQFNDDFEISISKKFIKIESAKTNPPKMFNQASLIKELKNLGIGRPSTYNPILTKLKDREYVEYPKSKPIVVTNKGYSANEYLYDHYLDFFNLNYTAEMEEKLDEITRGDFDYVNWLKNIYNALNFKVKKEIGEAKTEAICPRCGANLVYIKSRFNRGRGCSNFTITKCGYRKYEQPDGTWKEYIKEEKNIDDNTKKENKE
(1190) DNA topoisomerase 1 [Methanococcoides burtonii DSM 6242]
3
MHLIIAEKHIAAKRIAKILAPKEPKQVRVSGMDTFEYKNPDAEDRIIVMGLSGHIVQLDFPKAYNNWQKIDANELIDAEVITTPTHVKIVAALRKLGKEATHVTIATDYDREGELIGVEALNIIRKVNPDVEFDRVFYSAITKTEIEGAFANPASIDFDLADAGHSRQVIDLVWGASLTRYLSISAGRLGKLFLSVGRVQSPTLALIVDKEKERQAFVSKPYWEVNATLKDNDDALVNVQHKNSKFWEKEEADAVMEVIGDKASVSSVDSSKKTDKVPTPFNTTEFIGAASSIGFTASNAMRIAESLYTNGFISYPRTDNTVYPASIDLRAQIEIFSKGPFREYAQKLLAKDELVPTRGKKETTDHPPIYPASLAKKSELNEQDWKLYELVVRRFFATFADEAEWETMKVRFDISGEEFKANGARLVHQGWRWYYPYNAPQDRLLPALSEGDILDVTGKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYVHGNPLQPTKTSFAVIEALEKYAPTITKHDMTSQLEEDMDSIAEGKVKEDNVLKESRTMLHEVFTELANNSENISESLRAGLREDKVIGECSECGSKLMVRRSKRGSRFIGCNGYPDCNFSLPLPKSGQIIVTEKTCEEHGINHVKIINPGKRPWELGCPQCNFIEWKKTQEEEKAKQPKVPIPDKITDVPGIGKVTAEKLKNAEINTIDELRQANAIELSKATSLPAGKIMKWQELVT
(1191) DNA topoisomerase [Leishmania donovani BPK282A1]
3
MPTWLNVAEKPSVAKEMAQSLSGGNCRTVPSQSRFNPVYEFKFEGKTMLVTSVAGHLMEDQFPPNTKNWSTYPFQGLFLAPITKYVRADLEPVKKNLEALAGRADTLVLWLDCDREGENICFEVMQVVQSKRPQVQVKRAHFSALTARDLLNAVHNLKLPDKRLSDAVEARQEMDLRIGAAFTRYQTVKFRHLFAAIPGVLSFGPCQFPTLGFVVRRYWQQQGFVPEDFFTLQLQHGDTKFHSSRGSMYDQVAATLIYEDMLQAAAAEGHKGRITNVQQRPSHRRPPVPLATVVMQKLAATHLRIPSERCMTLAESLYQEGLISYPRTETDSYTFQESELLELVRVQIANADVAEYVAAMLADIATRVRPPLRGGHDDKAHPPIHPTKAWNATQDERGRLYNLIVRHFLASLSPDAVAATTQVSAEFGGELFSTGGTTILQRGWLDIFPYERWNNTCIPNYQIGDTFQPTAVPLKKGCTSAPPHLTETHLISLMDSNGIGTDATIAQHIKTVLDREYVKREGQSLVPTTLGIALASAYESLGLASLLQPQLRAQMELAMGDIANGAATKEQVVTAAVQLYEEIFSRLMANTNAFYEELKRYLQPAVETDACAVQATVVKANFIPCGTCGRLMDLVERAGERDREVWSVRCHACNKMYRVPNGRLNTLEPVSPPHTCPLCGFLALRVANREKQTSYHVCPHCFGSPPKAWSVTAYGSAGAAAPLPDVEAAAEFRCFQCTADCPLAKGLEAIGITTCIACRQHELRLRSGANGFFLSCRGYPSCHLRVSLPAAASVKPSPSQRCPACSAVLLTFDFSGRQGVPGLDMLDTICVRCDARIKDYIAVKGMPTGGANSSAVPSSAASVASTASRTYTLPSVKPSARRSVRGGGQRGGSGGDAAAANTSSGGVDPVCGCGAPAKQLVSRKEASRGKRFLTCANRQCSFFQWLD
(1199) DNA topoisomerase I [Bacteroides thetaiotaomicron VPI-5482]
3
MIAILTDKPNVGKEIARILGAHTREDGYMSGNGYMVTWTFGNMLSLAMPKDYGMDRPERGDFPINPAPFRLMVKHIKTDTGWIPDINAVLQLKVIEKVFDACESIIAATDASREGEMVFRYLYRYLECRKSYRRLWISSLTDEAVLEGMDNLRPGSLYDHMFLAADSRNKADWVLGLNASYALCQATGTGNNSLGRVQTPILAAISSRYRERENHIATDTFPVFISLCKNNTLLKMRCTEEFTDREAAARLYSDCKLAGHARVTAVSRQVREIEPPALYNLTELQKDANNYYGMTAGKSLEIAQKLYEKKLISYPRTAGRFLPRDVYDKLPRIMEKILNRKEFRPYVRSMGINIFDLPDKVVDEGQAAEHHAIIITDTYPEGLNREEMQLYMMIIGRMLEAFMPVCRAEYTTVDAVCAARNFRCHACRIIEKGWFGIFERESVIAGREYGFSPIPQLENGETAAVTGCSLIHRKDLTVSAYTDAELITYMDTAGLGTAATRTGILQTLIDRKYVRYSGKYIIPTRKGLYIYETVRNMKIAETALTSGWEAQLARMERGKLTQEEFMKGVLKLSREVTEDIFRKCER
(1203) DNA topoisomerase 1 [Pyrococcus furiosus DSM 3638]
3
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTANYEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELWYLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLELAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
(1204) DNA topoisomerase 1 [Pyrococcus furiosus DSM 3638]
3
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTANYEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELWYLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLELAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
(1208) DNA topoisomerase 1 [Methanocaldococcus fervens AG86]
3
MTALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKENKEFGTYPVFDVKWVPASVDKGKEYVNKYIKALKKLSKEANEFYVATDWDIEGELIGYHALKYCCGREKAKRMRFSSLTKKEIVKAFENPDEIDYGLVDAGESRHIVDWYFGINLSRALMNAIRAVNRWKTMSIGRVQGPALAFLTERELEIKKFVPKPYWVIEALLKDNLKAIHEKEKFWDEKEAKNIYEKIKDEKTAKVLEVKKTKRKIKPLPPFDLGTLQREAYSYFKISPKETQEIAQNLYEKALISYPRTSSQKLPKDRKYLEDILKIIKEHPIYGKWVGRILKDNLKPVGGKKEDPAHPAIHIVDVPKEELSEKEKKIYDLIARRTLAAFWDNAEREYLNIKIDIKGEIFKLSGSRTVKEGWHEIYYFPKFDEVELPPLKKNDIINIEKITITRKETQPPKRYTVASIIKELEKKGLGTKATRAEIVDKLIKRGYVVDEGSLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVLEEAEKKLRKILEEFKKKEKDIGTYLIKNLDSTNKKAKIVGKCPKCGGDLILIRYNKSRFVGCSNYPECDVKYSLPDKGRIKIPNKSCEACKSPILKIGDKEVCINPECPLKYVEVKEENKKCPKCGGDLILKKGIYGAFYGCSNYPKCKYTEPVNKKEKEVVGKCPKCGGDLVIREGKFGKFAGCSNYPKCKYTEKLKIVEKEEK
(1225) DNA topoisomerase [Chromohalobacter salexigens DSM 3043]
3
MRLIIAEKPSLARAIADALPTAPQRHEGYLVCGETCISWCVGHLLEQAPPDAYDARYQQWRLDHLPIVPRQWKLIPRSKARAQLAVIRKLLKRADTVVHAGDPDREGQLLVQQVIAHLGWRGSISRLLVSDLNRPAVRQALQCIEDNARYQSLFEAAEARSRADWVYGINLSRAWTLTGRQAGYQGVLSVGRVQTPVLGLIVRRDLDIEAFTPRPFYPLWADLKVEHGTLRAWWQPQAPHPLDEQGRLLERAPAEALAAHLPGAEGHLSELQSKRQTQSAPLPYSLSALQVDAARRYKLPAKRVLDICQTLYERHQLITYPRSDCRYLPEGHFAAAKKTLDTACAQDATLRGWYQGADFSRRSRAWNDKQVGAHHALAPTGRTFDASRLTGDEANVFRLIARNVLAQFYSPLVTRDVKAAFSIHGEHFRAQGREILEPGWKPLFTTRDEAPPLPALHEGEAARVVDCAVEDRQTRPPDPFTDASLIKAMMNIARYVDDATVKRTLRDTDGLGTEATRAGIMETLVTRGYIVRQQGALRATRTGRALIQALPDTATRPERTALWEQRLADIAEGRGDADAFLDALVGDVRQLLDQADAARMRQALATTGGAEPSSPSRGKKRGTRRGSGDASSSPRRRAGKSTARRRTSSKKGQT
(1226) DNA topoisomerase [Methanohalobium evestigatum Z-7303]
3
MSIVAFAEKNKAAAQIASILSEGNFERTTLEGVNVYEFKKDGKQWRIMGLSGHIMTYDYPQEYNNWKDVDPGVLIDTMPEQFITKQAFANAISRLAKDSDEIILACDYDREGENIGFEAKSIAEKVCNSPIKRARFSSLSTGEIKKAFQNPVEPDVNLANSAKARQILDLKMGVAFTRYITLSVQQKARTKGVLSIGPCQTPTCGFVYEREKAIKEFEPRDFWKIEAVFTHNDIDFQGTHRTGKFFDKQKADAVYNKISDCKTGQVTNKKVKETKSSPPYPLNTNEFLKRASKFLGLNSDRALEIAEQLYLSGFTSYPRTETNKYANDFDFQSRVAELTKKAHKELALEVFKNSEDGFNPRNGTKDAQDHPPIHPIKSANKGDINNAVNDSKGWDVYDLIVRHFLANLMQPAVFEKTRIEISVNDEIFDATGTVKKESGWIWVYPFEAKNDKILPEIEINEKLKINKITNTNSQTTPPKRLTESELLTLMDKNGIGTKATAPTHIETNKKRGYFETKGKSISILDTGFTLMDALDKSVPLIVKPEIRARVEQLIQDVEDGKKSLDGAINEGTALIKQMYSQLTSNKDEMVSQIAGTIYDESVAADSDNYIGKCSECSRVLRIVTTDNGRFVGCTGYPECKNTYPLPKKGALNIMKSRECKKGAPAVIKVGNKYHWAVGIGPCFKCDMENECFPPEIVGQCPNCDGYMFLIKTKDSRFLGCTNKCGYTQSVPKSGRLTILDDTCECGWNIVRVKEKEKEAKEFCVNRKCINKL
(1236) DNA topoisomerase 1 [Methanococcus vannielii SB]
3
MTGLIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGEDIIVASAVGHLYTLQEKEKTKFGDYPVYDIEWVPASTLDDKKYIQKYIDTLKKVSKEASKFYVATDFDIEGELIGYHALSHACGQKNAHRLRFSSLTKKEIIKSFENPNQIDFGLVDAGDSRHKIDWYFGINVSRALMQAVSSAKRWKTLSTGRVQGPALAFLVDKEIEIKNFIPTPYWVLEAVLDNNLKALHELEKFTDEKRAKEAYEKVKNEKEALVTEIKKTLKSIPPNVPFDLGALQREAHNVFRFSPKKTQEVAQKLYEKGYCSYPRTSSQKLPDDKAYMDEVLKNLSKNKEYSKYIELILSEGRKPVDGKKDDPAHPAIHAVDVPKENLPDDELKLYELIARRTIALYLDDAKREYSKISLEINGEPFKLNGSRTIEEGWHELYYFTKFDEIELPTLKKKDLLRINEIAFEEKETKPPKRYTMASIIKELEKRTLGTKATRADILEKLTKRGYVIDDGSLTVTELGIGVTETLRKFCPEIVEETLTRDLENKLELIQDKKIKKETVIKETKDKLTKILGEFKLKEKEVGNELVEKLDSTNRSMQVIGKCKCGGDMIIIRTKGKKRFVGCSNYPECEITFPIPQKGRIKVINEVCKTCENPIIGLDSIKICVNPDCKTRISEEDRKEMEKAALEEKSCPKCGGKLSIKKGPYGVFRGCENYPKCKYTEKLNGESNEKEVIGKCPKCGNDLLKRKGRFGDFIGCSNYPKCRYTEKIEKKKEGDLEDKIEVTKEKVKAKETLKSEKNLDKTLDNPKPKRTKTASKKKKEELKN
(1243) DNA topoisomerase 1 [Mycoplasma genitalium G37]
3
MIKNLVVIESPNKVKTLKQYLPSDEFEIVSTVGHIREMVYKNFGFDENTYTPIWEDWTKNKQKNPKQKHLLSKFEIIKSIKAKASDAQNIFLASDPDREGEAISWHVYDLLDQKDKAKCKRITFNEITKKAVVDALKQPRNIDLNWVESQFARQILDRMIGFRLSRLLNSYLQAKSAGRVQSVALRFLEEREKEIAKFVPRFWWTVDVLLNKENNQKVVCANKSIPLVLREINPELSASLKLDFEAAENVSGIDFLNEASATRFANQLTGEYEVYFIDEPKIYYSSPNPVYTTASLQKDAINKLGWSSKKVTMVAQRLYEGISVNGKQTALISYPRTDSIRISNQFQSECEKYIEKEFGSHYLADKNKLKRHKKDEKIIQDAHEGIHPTYITITPNDLKNGVKRDEFLLYRLIWIRTVASLMADAKTSRTIVRFINQKNKFYTSSKSLLFDGYQRLYEEIKPNTKDELYIDLSKLKIGDKFSFEKISVNEHKTNPPPRYTQASLIEELEKSNIGRPSTYNTMASVNLERGYANLVNRFFYITELGEKVNNELSKHFGNVINKEFTKKMEKSLDEIAENKVNYQEFLKQFWTNFKSDVKLAENSIQKVKKEKELVERDCPKCNQPLVYRYTKRGNEKFVGCSDFPKCKYSEFSNPKPKLTLETLDELCPECNNKLVKRRTKFNAKKTFIGCSNFPNCRFIKKDNAAEFKQ
(1244) DNA topoisomerase 1 [Mycoplasma genitalium G37]
3
MIKNLVVIESPNKVKTLKQYLPSDEFEIVSTVGHIREMVYKNFGFDENTYTPIWEDWTKNKQKNPKQKHLLSKFEIIKSIKAKASDAQNIFLASDPDREGEAISWHVYDLLDQKDKAKCKRITFNEITKKAVVDALKQPRNIDLNWVESQFARQILDRMIGFRLSRLLNSYLQAKSAGRVQSVALRFLEEREKEIAKFVPRFWWTVDVLLNKENNQKVVCANKSIPLVLREINPELSASLKLDFEAAENVSGIDFLNEASATRFANQLTGEYEVYFIDEPKIYYSSPNPVYTTASLQKDAINKLGWSSKKVTMVAQRLYEGISVNGKQTALISYPRTDSIRISNQFQSECEKYIEKEFGSHYLADKNKLKRHKKDEKIIQDAHEGIHPTYITITPNDLKNGVKRDEFLLYRLIWIRTVASLMADAKTSRTIVRFINQKNKFYTSSKSLLFDGYQRLYEEIKPNTKDELYIDLSKLKIGDKFSFEKISVNEHKTNPPPRYTQASLIEELEKSNIGRPSTYNTMASVNLERGYANLVNRFFYITELGEKVNNELSKHFGNVINKEFTKKMEKSLDEIAENKVNYQEFLKQFWTNFKSDVKLAENSIQKVKKEKELVERDCPKCNQPLVYRYTKRGNEKFVGCSDFPKCKYSEFSNPKPKLTLETLDELCPECNNKLVKRRTKFNAKKTFIGCSNFPNCRFIKKDNAAEFKQ
(1245) DNA topoisomerase 1 [Mycoplasma genitalium G37]
3
MIKNLVVIESPNKVKTLKQYLPSDEFEIVSTVGHIREMVYKNFGFDENTYTPIWEDWTKNKQKNPKQKHLLSKFEIIKSIKAKASDAQNIFLASDPDREGEAISWHVYDLLDQKDKAKCKRITFNEITKKAVVDALKQPRNIDLNWVESQFARQILDRMIGFRLSRLLNSYLQAKSAGRVQSVALRFLEEREKEIAKFVPRFWWTVDVLLNKENNQKVVCANKSIPLVLREINPELSASLKLDFEAAENVSGIDFLNEASATRFANQLTGEYEVYFIDEPKIYYSSPNPVYTTASLQKDAINKLGWSSKKVTMVAQRLYEGISVNGKQTALISYPRTDSIRISNQFQSECEKYIEKEFGSHYLADKNKLKRHKKDEKIIQDAHEGIHPTYITITPNDLKNGVKRDEFLLYRLIWIRTVASLMADAKTSRTIVRFINQKNKFYTSSKSLLFDGYQRLYEEIKPNTKDELYIDLSKLKIGDKFSFEKISVNEHKTNPPPRYTQASLIEELEKSNIGRPSTYNTMASVNLERGYANLVNRFFYITELGEKVNNELSKHFGNVINKEFTKKMEKSLDEIAENKVNYQEFLKQFWTNFKSDVKLAENSIQKVKKEKELVERDCPKCNQPLVYRYTKRGNEKFVGCSDFPKCKYSEFSNPKPKLTLETLDELCPECNNKLVKRRTKFNAKKTFIGCSNFPNCRFIKKDNAAEFKQ
(1250) DNA topoisomerase [Pyrobaculum islandicum DSM 4184]
3
MILIVAEKRSVAQAIARYLGGTYKVEKIYGVSAYRFLYGNREAVALGLSGHIMDYDFTARQNVWSWLPPEELFKTSPILVLREEAIKYVRALRSLARKAEEVYLALDADSEGEAISYEVALVVRLVNKNVKIYRVRFNAVTYKDIKIAFQNPTKLDLKQVEKVFSRMQIDLTLGAVFTRFLTLTVRDLLEKGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKAVVEIRGYKIEMSADVRFKTRKEAEAVATTIKRGVVKAAIYRPHYIQPPEPLETVELERRASRWLGINSKKTLDIAEELYRAGYISYPRTETTIYPPTLNLREILQELIRGEHSRYVEELLLRGFRPTRGDSDDGAHPPIYPTKGATKSEIYKTFGKIGDNAWAIYDFVVRHFLATLSPPAQVEKQKIVVDFGKIQLEVEGQRTIDEGYWRIYPWERQSDRPLPRVYVGDEVHAIKVEVVERETEPPPPMSESELLALMKKYGIGTDATMQDHIYTNIKRGYMKLQKGKCIPTKLGETLAITLFQYTPELIEPTVRARIERAIQGIVKNGISPNRLIQEIKSEFEKYYNDLKKHRDEIRRALETVLNSKARERSGTY
(1259) DNA topoisomerase 1 [Mycoplasma haemofelis Ohio2]
3
MKHDLMLIESPNKIATISKYLKGTNIKVIATIGHFREIDGRYYKPLGFDLETYDVKWKNDSEKVVKGKKIDIIKEINKAADASENIYLSTDPDREGEAISWHIFSILSEKNRKKCQRVVFNEITKRAIEQSLLNPRQLDQNQINSYLTRKLLDRCIGFKLSDFTHKTIGGQSAGRVQSIALKFLKDKDREIKSFVPEHWFNLKIFLDNGLELTLKEVSPEFKVDLHPTLKNGFVNFLKEEDAKLVEQSLLKDYKLVSIDDPKREITKPPKAFKTSTMQEKAINKLGMSSSVVERTAQRLYEGVQIDGETLALITYPRTDREDLSLTFVEEAKSFILGNYSEVYWGSQRAIKKGNNDSLVQGAHEGIRPTDINITPDSIRGKIPPNELKLYTLIWTYAVASLMADAVYENTLYKFENNRHKLTANCRVEKFDGFKILFRKFFPNSDDGDPSFPSNLEINKSYSEGNKEMKKVDKKPPSPYTEASLIKSLDSEGIGRPSTYSHIVNIVLQREYAVRKEGKLIVTEFGSSVADALEKYFPDIMKYDYTRNMEKELDNISENKTEWKSFLKDTFGSFFEVLKVANEKAFKESMLGRQCPKCQSELCNRYSKNGNKFISCSAYPKCDYIENVKEEGTLLDEECPECHSKLERKKSKSNSEFVGCSNYPKCKYIKRDVEVLDKKCPNCDHDLVKKKNRWGSFFVSCSNYPTCKYSRSLKGNDDK
(1263) DNA topoisomerase 1 [Methanosphaera stadtmanae DSM 3091]
3
MSELIICEKPKVAEKVAKALSDSPVKNSYKRVPYYEFTNGNGTKITVLSAVGHLFSLKAKNKKDKRLFDVEWVPLSETDKSKKYVKNYIDTIKKFSKDADRFIHACDYDTEGTLIGFNALRYICGEDSIDKSFRMKFSALTKKDLIESYSNAYPLKEDKSWVDSGETRHVLDFLFGVNISKSMTDSVLNVTNRYVQLSAGRVQTPTLAILTEREKEIQKFIPEPYWLIKAKLQKSIVADHKKGKIFDKKEVDAILKNCKGKDATVEKITNRKTKKDLPVPFELGTLQSEAYAQFGFTPRKTQQIAQNLYVEGYTSYPRTSSQKLPESLGLPNILSQLSKHPKYKDKISQLEQPYKPHEGKKTDEAHPAIHPTGTLPKDISEDYQKIYDLITYRFISIFGKPAEMESIKVELDIGGEPFSFSRQRISKEGWLSLDPYQYKKVKNEEFPEIKEGQTTKAKVASEEKETKPPARYNQASIIRELEKRGLGTKSTRANIVSILYTRKYVEGKKIEVSQLGQQIINTLEKYSERITSEQMTREFETDISNIKENEITEATVIEDAKKELNGILDSIDDNIEDIGKELYGAYEQSRVVGKCGCGGNLIIISSPRGGKFVGCSNYPDCKKTYSLPAGANVLKTTCEKCGLPLISYGKPRQRACLDFECANGGQKSTNDVVGECPDCGKDLIKRMGRFGEFIGCTGFPKCRFTSSIDDFEKSKKESEKKD
(1265) DNA topoisomerase [Acidilobus saccharovorans 345-15]
3
MRSSRDCNIPQYYDVIIAEKPKAADKIAHALGSPFRCAIGRVPIYILNVNGTNIVVVSSAGHMFGPSTGVEGLPVTMIRWEPLWRFDRRSKYLRPYYEVLSRLVPKARYFINACDYDIEGSTIGYKIIEAFGDKSRAKRMKFSSLTAAELRQAFRRLQPLDVNNAMAGIARAELDWLWGINISRLLMKSYREVTGERLSLSAGRVQTPTLAEAIRRWVKINTHVPIPQPSLTARLLHKGVEFTAYPLGWSVSTVKEAREVAKEVKEGMYMEVISLSRASESVRPPPPFNLTDLQKEAARIYGLSPYKTQEVAEDLYLAALISYPRTNSEKLPPTLNYREVLDSIGRQPKYRGLVGDLLRETGGVLRPREGPADDPAHPAIYPTGEQPTRLDRVHETVYDLIVRRFMAAFAPPATLSTVSAVLTDVKARRWEARGLNVAERGWLKYYPFHKFDESQLPTLNRGDRPLVRSITVKVSWSGPGLRLSRLSLLEWMEANDLGTKGTRARIIETLYKRGFITSRGSHAEITNLGYAVYKVLSEVAPELMSVSLTRDFERMLDEISMGKASREEVVSRAKKYISELVERQLNSNNIKVMGTYLAEFIGKVRPRSRCAICGRPTDGQSLCELHLAAKSNLEKSIDEVARRLGVSKEEALRRISNNRLAGKWVRDVAALMISGKERP
(1272) DNA topoisomerase 1 [Aeropyrum pernix K1]
3
MVAEKPKAAAKIAYALSDGRGVLRCSEYGVPYWIVRRDGAAIVVAPSAGHLFGPHTDSRGFPVFDFEWRPIFEFDRGAGYLSKFYRMLSRILPGASLYVNACDYDIEGSVIGFKIIEAFGDVNRARRMKFSTLAPQDIRRAYARMERLDVEMIEAGMARSEMDWLWGINVSRALMEAARRAAGRRVILSAGRVQSPTLVEAYRRWREINLHVPKASVAVKITAEKGGGVFDARPHGWKPQSLETARSIKSELRKNPWLAVEEVRSERSILRPPPAFNLGDLQKEANRILGLPPLRTQSIAEELYLEALISYPRTNSQKLPPSINYRAILDKLAHGPLGREARELLKETGGVLRPVQGSKDDPAHPAIHPTGEKPSQRLSKEHMAVYELIVRRFLAAFSREAIVSKSSVLLRDFQGRVWRAEGLRVEDLGWLKYYHYSTPGEKPMPPLDRGDKARVVRVDVRVEWSQTPVRLDKASLLRWMESVNIGTEGTRARIIETLYKRGYLEGSRKSEVTPLGEAVAVIIQTLFPELSKPDLTRRFESMIEDIRSGRRTRQEVIDMSKKTISKLLESFLDRLDTAVREIGVSLGSVEVEAACHLCGRKAVSAVSGYRLCSHHMEAFDRLRKALPNLASTISSTPREALEAIARGRSRAGAWVRDVAALALRDDGLYKALL
(1275) DNA topoisomerase 1 [Staphylothermus hellenicus DSM 12710]
3
MKVKAKKSIIDYILSYSKKQEKEHVKAEEKTLPRKVTEKAKIKITRNIWDLTGKIVVIAEKPKAANKIALALSKNPIRKSIYGIPYYMIKTKNGLIIVASAAGHLYGLHTDQYGYPVFRYEWKPLYQIGHKAKHTKKFITALSKLCSNADYYVNACDYDIEGSVIGYLIIYFHGDLEKSLRAKFSSLTIGELRESFRKLTSLDWEMIEAGLCRHELDWIWGINISRALMSSVKMASGKRVILSAGRVQTPTLRYIVEKDIERRLFIPLPQYSLSINISKNNYEIHVEYKGKAVETKKKAKEIIKDIKNTGYLTVKKYEEKKYWLNPPPAFNLGDLQEEAARIYRFSPYKTQSIAEKLYLDALISYPRTNSQKLPPTLNYKGIMNKLSRINNYKELISNLLVETRGVLKPVQGPKDDPAHPAIYPTGVKPKDLGKDEWKIYDLIVRRFLAAFASRARISHRIVYLEYPKDPSMVFMASGRKILELGWLRYYPFSMPEERFLPRFQHGEKVKITKASIRKTYTKPPEKISRIKILRWMENVGIGTEATRARIIEILFNRKYLRSVGGRVEATDLGLGIIEVLMEYFPEITSVSLTRYFEGEMEKIRLGIRRRDEVVRDAKNTLIKLIVSFDKKKYQIGKTLSYRLGYLTPTNKCMLCNREAYKNNLCKYHYQALNTIVKTYEEWKRREGVDWDKYLSSIKKLKSTGKWIVEVIQNFEKIKYSHSK
(1280) DNA topoisomerase III [Candidatus Caldiarchaeum subterraneum]
3
MTSTSDKDTMDGEKLIIVAEKASVARAIKAVVSAAKANAVVSSVRGHMMEADLPDGYEWGAKHPFEIIKLRKVVDKISDNRVFEQLVKVFSGGGVLVIATDNDSEGELIGYEILQVYRRVTGGEPVVYRMRFNSVDRRELFASLRNLEKGLNMRWVEKARFRQIFDLVTGAAFTRLLTLSTRRLAPVRVISWGSCQTPTLNFVVEREKEIQQFKPQKYWVIEATLRKASGEEFKAATQQIWNRDEAEQVFEKARKAGEAVVTSYTKSEKTLPRPLPMRTDDVLRDLTRITGVSANRLLSMMEELYAEGYISYPRTDTNRYRRGFDFQTPLKAVTAADALRDAKPDKAEPDPRNGSRDDGAHPPIYPVATFRGSGVLMQIWEYIACRFYANAFFDDAVQSTAKAEIGIDGIAFSAEGSSVTKQGYLQVFSYFRPRDKPLPELMVGEKLQIIDVTIREDETKPPPRLTEADLLRLMEKNGIGTDATRASFPQLITERNYAVRAGRFFKPTPLGMALIESLAEADTRLITPETRRLVEDYMAKIERGETSFQESLEQSLSLYEELLRRCSDKIDEISRRLAQHVKPFARKRQRKKKGEPSLMNSNKLNK
(1281) DNA topoisomerase III [Candidatus Caldiarchaeum subterraneum]
3
MTSTSDKDTMDGEKLIIVAEKASVARAIKAVVSAAKANAVVSSVRGHMMEADLPDGYEWGAKHPFEIIKLRKVVDKISDNRVFEQLVKVFSGGGVLVIATDNDSEGELIGYEILQVYRRVTGGEPVVYRMRFNSVDRRELFASLRNLEKGLNMRWVEKARFRQIFDLVTGAAFTRLLTLSTRRLAPVRVISWGSCQTPTLNFVVEREKEIQQFKPQKYWVIEATLRKASGEEFKAATQQIWNRDEAEQVFEKARKAGEAVVTSYTKSEKTLPRPLPMRTDDVLRDLTRITGVSANRLLSMMEELYAEGYISYPRTDTNRYRRGFDFQTPLKAVTAADALRDAKPDKAEPDPRNGSRDDGAHPPIYPVATFRGSGVLMQIWEYIACRFYANAFFDDAVQSTAKAEIGIDGIAFSAEGSSVTKQGYLQVFSYFRPRDKPLPELMVGEKLQIIDVTIREDETKPPPRLTEADLLRLMEKNGIGTDATRASFPQLITERNYAVRAGRFFKPTPLGMALIESLAEADTRLITPETRRLVEDYMAKIERGETSFQESLEQSLSLYEELLRRCSDKIDEISRRLAQHVKPFARKRQRKKKGEPSLMNSNKLNK
(1326) DNA topoisomerase 1 [Archaeoglobus fulgidus DSM 4304]
3
MVMSWLIITEKDNTARRIASILFKDVKTLKKGRVSYYHSPSNDAYVVGLKGHIVELDFPKELNNWTKTPLEKLLQAELVKKVKERTISSILKEIAKKADRVTVATDYDREGELIGVEALEIVKSVNPTVKVDRVRYSAVTEKEIRSAFSKPVKVDFNLANAALARQKIDLIWGATLTRLISVHSGRMGKDFLSVGRVQTPTLRLIVDRELEIQNFKPEKYYEIFAEFEGFIAKHPKRYGSKEEAEKLFAKIGETAKVEEFTRRRMEENRPTPFNTTEFLREASKFMSPHKAMNIAETLYMNGYISYPRTDNTVYPPTINLIEIVSALSSVFPREAQIVLSQDKITPSRGRRETKDHPPIYPTGVAKRGELSKDEWTIYELVVRRFLATLAPKAVWDVRRVVLDSNGVKFVANGRQLVEAGWRDIYIYSKAEETELPLLKKGDVLRILKKRLEEKETKPPGRYSASSLIKMMEKLNLGTKSTRHEIIQKLVSRRYIHGNPFRPSETAFSVINVLKETAETITLPDMTAKLENEMDLIAEGKKREPEVVDESREMLLQILRAIDYRKLSKDLREGVKKDKIVGKCPECGGELVVRQSKAGKRFIGCSNYPDCTFTLPLPQNGTLYITAKQCKEHEIKEVKIRTKKGYWNLGCPYCNYLNWKKENS
(1327) DNA topoisomerase 1 [Thermococcus sp. 4557]
3
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVGYYEFTRDGKRIIVAPAVGHLFSLAPKVKTYGYPIFDIEWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVIGYTALKYACGIDPSRAKRMKFSALTKKDLLKAWYNLEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWQVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMLLEKNGEQYTAVYEKERILDEDEAKRIVEEAKKGPAFVEKVEVKQQKRNPPVPFDLGTLQREAYSAFGYSPKKTLELAQKLYERGLTSYPRTSSQKLPKNLNFRPILQNLAKLPEYKPFAHELLGKERLKPVEGKKEDPAHPAIYPTGELPKPGDLTKDEQNLYDLIVRRFLALFMEPAVREIMKVVINSNSHRFILGGARTVKEGWLKVYGKYVKFDEVILPAFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKRMEDLGIGTKATRAQILETLYSRGYIEGKRKIKVTPLGMRVVEALEKNVPDIVSVELTKAFEEKMAEIMAGKADREDVIEESKNQLIKILKVFKEKELDIGKMLMETTGTGATTSKTAARKAGAVKELSGEEEKAVKKAVDGGERRKEPLVLGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLLQRGEIIPTDKTCCGGAPVVKIREKGREYEICVDMNCRDWKKGKK
(1333) DNA topoisomerase [Arabidopsis thaliana]
3
MSRRGGGPVTVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDREGENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQEIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPEEFWTINCSHQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRFESWGGSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWLPGPTLEASVTTNVCQSCGPGPVYKILFKFRQIGIPPGFDVNHLGCVGGCDDILKQLIDICGTGSRSQARRTPGTAPSNNIQGSNTRQSNVCIHCQQRGHASTNCPSRVPASRNSRPTATNPRNDESTVSCNTCGSQCVLRTANTEANRGRQFFSCPTQGCSFFAWEDSINNSSGNATTGSNSGGSGRRGSRGRGRGGRGGQSSGGRRGSGTSFVSATGEPVSGIRCFSCGDPSHFANACPNRNNSNGNYF
(1334) DNA topoisomerase [Arabidopsis thaliana]
3
MSRRGGGPVTVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDREGENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQEIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPEEFWTINCSHQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRFESWGGSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWLPGPTLEASVTTNVCQSCGPGPVYKILFKFRQIGIPPGFDVNHLGCVGGCDDILKQLIDICGTGSRSQARRTPGTAPSNNIQGSNTRQSNVCIHCQQRGHASTNCPSRVPASRNSRPTATNPRNDESTVSCNTCGSQCVLRTANTEANRGRQFFSCPTQGCSFFAWEDSINNSSGNATTGSNSGGSGRRGSRGRGRGGRGGQSSGGRRGSGTSFVSATGEPVSGIRCFSCGDPSHFANACPNRNNSNGNYF
(1335) DNA topoisomerase [Arabidopsis thaliana]
3
MSRRGGGPVTVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDREGENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQEIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPEEFWTINCSHQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQTRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRFESWGGSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYATKDANTRFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMALRKNRDGNFMVGCMNYPQCRNAVWLPGPTLEASVTTNVCQSCGPGPVYKILFKFRQIGIPPGFDVNHLGCVGGCDDILKQLIDICGTGSRSQARRTPGTAPSNNIQGSNTRQSNVCIHCQQRGHASTNCPSRVPASRNSRPTATNPRNDESTVSCNTCGSQCVLRTANTEANRGRQFFSCPTQGCSFFAWEDSINNSSGNATTGSNSGGSGRRGSRGRGRGGRGGQSSGGRRGSGTSFVSATGEPVSGIRCFSCGDPSHFANACPNRNNSNGNYF
(1344) DNA topoisomerase 1 [Mycoplasma pneumoniae 309]
3
MSKNLVVIESPNKVKTLQKYLPNDFEIVSTIGHIREMVHKNFGFNEADYSPVWEDWTKSKKKFSSLSFKGNLKGKKLLSKYDIIKSIKEKASKATNIYLATDPDREGEAISWHVYDVLDEKDKSKCQRITFNEITKNAVLDALKNPREIDQSWVQSQFARQILDRMIGFRLSRLLNNYLSAKSAGRVQSVALRFLEEREQEIRSFVPRFWWTLDVLLNPKAEGVREACANRSIPIVLREINPALRAGLKFEEEKSVSGIDFLDEASAKKFGEQLKGVFEVYNIDETKHYSSSPNSAYTTASLQKDAINKLGWSSKKVTLIAQHLYEGVSINGEQTALISYPRTDSTRLSAQFQQSCKEYILNHYGEKYLSNRIVSAKGKKGEKIIQDAHEAIHPTDMNITPEMVKNAIKKDEFLLYRLIWIRTVASLMADCKKSHTHIRFINDGNKFYASSKSLVFDGYRKIYEHFENKESNDLYIDLDKIRVGDRFMAKDIKITARQTHPAARYTQASLIEALEKSNIGRPSTYNTMASVNLDRGYASLNKHAFHVTQLGEQVNEELSKHFGKIINKEFTKNMEKSLDEIAENKKNYQEFLRDFWSNFKEEVKLAEGSIQRVKKEKEFVGRDCPSCASPLLYRYTKRGNEKFVGCSKFPNCKYNEFSQNKPNLTLEKLEELCPECNSQLVKRRTKFNPNKTFVGCSNFPRCRYIKKDNAS
(1345) DNA topoisomerase [Leishmania infantum]
3
MPTWLNVAEKPSVAKEMAQSLSGGNCRTVPSQSRFNPVYEFKFEGKTMLVTSVAGHLMEDQFPPNTKNWSTYPFQGLFSAPITKYVRADLEPVKKNLEALAGRADTLVLWLDCDREGENICFEVMQVVQSKRPQVQVKRAHFSALTARDLLNAVHNLKLPDKRLSDAVEARQEMDLRIGAAFTRYQTVKFRHLFAAIPGVLSFGPCQFPTLGFVVRRYWQQQGFVPEDFFTLQLQHGDTKFHSSRGSMYDQVAATLIYEDMLQAAAAEGHKGRITNVQQRPSHRRPPVPLATVVMQKLAATHLRIPSERCMTLAESLYQEGLISYPRTETDSYTFQESELLELVRVQIANADVAEYVAAMLADIATRVRPPLRGGHDDKAHPPIHPTKAWNATQDERGRLYNLIVRHFLASLSPDAVAATTQVSAEFGGELFSTGGTTILQRGWLDIFPYERWNNTCIPNYQIGDTFQPTAVPLKKGCTSAPPHLTETHLISLMDSNGIGTDATIAQHIKTVLDREYVKREGQSLVPTTLGIALASAYESLGLASLLQPQLRAQMELAMGDIANGAATKEQVVAAAVQLYEEIFSRLMANTNAFYEELKRYLQPAVETDACAVQATVVKANFIPCGTCGRLMDLVERAGERDREVWSVRCHACNKMYRVPNGRLNTLEPVSPPHTCPLCGFLALRVANREKKTSYHVCPHCFGSPPKAWSVTAYGSAGAAAPLPDVEAAAEFRCFQCTADCPLAKGLEAIGITTCIACRQHELRLRSGANGFFLSCRGYPSCHLRVSLPAAASVKPSPSQRCPACSAVLLTFDFSGRQGVPGLDMLDTICVRCDARIKDYIAVKGMPTGGANSSAVPSSAASVASTASRAYTLPSVKPSARRSVRGGGQRGGSSGDAAAANTSSGGVDPVCGCGAPAKQLVSRKEASRGKRFLTCAHRQCSFFQWLD
(1348) DNA topoisomerase [Hyperthermus butylicus DSM 5456]
3
MVRAGYCSAGFGYTLVIAEKPKAARKIAEALSDKPIACKLGGIPYWIVTWMGTRYVIVPAAGHLFGLTTDKHGFPVFEYYWAPLWAVDSSSAHTRRFLEAIKKLARHAVRFVNACDYDIEGSVIGYNILRALGVEKRALRAKFSALTRQDVRRAFSRLERLDWDMINAGLARHELDWLWGINISRALMESLRSVTGRSKVLSAGRVQSPTLVEAVSRTIKRNLFVPLPYFTVTATVELGGKARRLQVASFELRSEAQRVARQLRATGYLVVREYSEYVERIPPPYPFNLGDLQVEASRILGFSPYYTQKLAEELYLEGLISYPRTNSQKIPPTIDISAIVQALVRQTRYRELVEYLLRATRGVLRVNNGPKEDPAHPAIHPTGEPPHSGLSKNHLRLYDLIVRRFLASMAPPAVLVRARLILSAEGLGSASITGVRIVSPGWMQIYYWAKPSEEYIPRLYRGQRIQVKSVSVQTSYTQPPELHTKTSLVKWMESKGIGTEATRARIVELLFERGYLRSEGGRVQATELGLTVANILQTYFPDITSVELTRRFEELLEAIRMGKVSKDAVISEARRFLAGILSEFKVKSMHAVGMELAYSLGLLKPPRQCPICGRRAEGEYCSYHEAAIRKIVEAYHEWRRRTGITCREYLEKLAAMRSTGKWVREAAKYLLARNVCPKGLTA
(1352) DNA topoisomerase 1 [Mycoplasma arthritidis 158L3-1]
3
MDQKVLIVESPNKVKTIQQYVGSDYNVVSSVGHILKLSTSGVDGLGIDFTNWEPMMIQDRTKAKVIKALKDATKNAKEVLIATDPDREGEAIAQNLVDTLKLSKIYRRIKYNEITAEAIKEALENPQMIDDNLVKAQKTRRMLDRIIGFRLSQLMKRKVKNAPSLPSAGRVQSIALKLVCDKEKEIKAFIPIKYNKIQAKISEDVIADFYYPTNSDFKNDNTWILPEKIDSIVAELNKNKSLLVKDFKVSQRKESQITPFKQSVLYKEAKYSATTVQISAQKLFEMGLISYPRTDSTRMSDTFIAKAREYIKEKFGENYVASDIKSFSGAQDAHEAIRPTDIYLIPQVAKTKYDLGEVESYIYTIIYNKTMSSLMTPPVREIYRYELVNGLYYFKMSYSKVIFDGYYRVLNFEEPKPLPKYEIGEAIPVLEFTRFDKETQPPARYNEGSLIKMLDDIKVGRPSTFASTINIIKKRLFVETINGALHPTVFGEVVLKKLIEGFPNTITEEYTAQVEEELDEVSEGKADYKILLEDFWNRFQRSYDDASKTIEISIMPQEFLERSCPRCGSTLLYRNNSKKHTKFIGCSNFPACRYSENADGTPTGQKTYKPRYYKKSSKAN
(1360) DNA topoisomerase type IA central domain protein [Caldivirga maquilingensis IC-167]
3
MDKLIVAEKNSVAKAIAQYLAEGGYTLRRIGIVPVYFFKVNGEYWASMGLRGHILDFDFEHSYNNWNRVEPGKLLDLEPVMVIRGWDRPYVTALVELSKQAREIILALDSDVEGEAIAYEVMLVTRLRKPTLRFRRALFSAVTRDDIRRAFSKLTTINVNLARKVFTRMVIDLKYGATFTRLLTLSAKSSKAPLNRGEFLSYGPCQTPVLNLVVQRALERENFKPEVYYKIKLIIEANGELIELESIDKFKNLKEAQEALSRVKAGKAVVKNIEAKRVHVNPPKPLETVELERRASRFLNIRSKQTLDAAEELYRQGYISYPRTETNIYPPTLDLRGILRNLTSTSTYGQYARHLLAGELRPTAGKDNDNAHPPIHPVKAADKPELMARFRDFKYWLIYDLVVRHFLATLSPPALIEEQRLTVDAGGVLFEASGLRIINDGYFTIYPFERPRANPLPLSALRIGMQVTVKDAKVVKRKTTPPPYLSESELLRLMRKYGIGTDATMQDHIHTNVKRRYFKIIKGQCVPTPLGKALITSLSKYAPTLIDPNFRSRMESMLSLIGSGKEMPDSVRRRLEEEAARVYTSMKPNSNQLGEELAKALRSMVNEKGA
(1361) DNA topoisomerase 1 [Haloquadratum walsbyi DSM 16790]
3
MSQGPELIITEKDNAARRIADILSGDSATADREQGVNVYKWGGKRCIGLSGHVVAVDFPQEYSDWRDVEPVELIDAPIEKNPTKQNIVTTLKKLARRARRVIIATDYDREGELIGKEAYELVRRVNESTPIDRVRFSSITEESVTTAFENPDDLDFNLAAAGEARQVIDLVWGAALTRYLSLSAGQLGSDFISVGRVQGPTLKLIVDREREIEAFDPEDYWELFVDLTQADKPIEVSTDDTAAEFEAQYFYHADDGTEAERITEESTAKTVFETLESASIAHVDSVKRRTRTDEPPAPFNTTQFISAAGSIGYAAQRAMDIAEDLYTAGYITYPRTDNTVYPDELDPRELIEALTNGSRFGSDARDVLDQETLSPTTGDEETTDHPPIHPTDELPKPSELDDDKWEVYELIVRHFLATVSNPATWEHLRIVAIVDDTYSIKSNGRRLLNPGYHAVYPYSNATESLIPDIEDGETLRLIDSRIEAKQTQPPRRYGQSRLIETMESMGIGTKSSRHNVIQKLYNRGYIESDPPRPTQLARAVVEAAEEFAELIVSEEMTAQLETDMQAIAEGEETLESVTSASRSILTDVFKKLMNTDAEIGDHLQRSMKADKTIGPCPQCEGDLITRKSQAGSHFIGCDSYPDCEYTLPLPSTGKPHILETVCDVHNLQQIKMLAGKRSFVHGCPLCEAEAADEQADRVIGTCPECNAHADGELAIKRLRSGSRLVGCTRYPDCEYSLPLPRQGEIDVTDNICDEHALPALQILEADENTTKDKTTKESDDIWELGCPICNYREYQSDQTDSSTLESVHGIGAKTAEKLKDAGVDTVSALKSAEANTLADRVDGVSVDRLRKWQSTAD
(1376) DNA topoisomerase 3 [Saccharomyces cerevisiae S288c]
3
MKVLCVAEKNSIAKAVSQILGGGRSTSRDSGYMYVKNYDFMFSGFPFARNGANCEVTMTSVAGHLTGIDFSHDSHGWGKCAIQELFDAPLNEIMNNNQKKIASNIKREARNADYLMIWTDCDREGEYIGWEIWQEAKRGNRLIQNDQVYRAVFSHLERQHILNAARNPSRLDMKSVHAVGTRIEIDLRAGVTFTRLLTETLRNKLRNQATMTKDGAKHRGGNKNDSQVVSYGTCQFPTLGFVVDRFERIRNFVPEEFWYIQLVVENKDNGGTTTFQWDRGHLFDRLSVLTFYETCIETAGNVAQVVDLKSKPTTKYRPLPLTTVELQKNCARYLRLNAKQSLDAAEKLYQKGFISYPRTETDTFPHAMDLKSLVEKQAQLDQLAAGGRTAWASYAASLLQPENTSNNNKFKFPRSGSHDDKAHPPIHPIVSLGPEANVSPVERRVYEYVARHFLACCSEDAKGQSMTLVLDWAVERFSASGLVVLERNFLDVYPWARWETTKQLPRLEMNALVDIAKAEMKAGTTAPPKPMTESELILLMDTNGIGTDATIAEHIDKIQVRNYVRSEKVGKETYLQPTTLGVSLVHGFEAIGLEDSFAKPFQRREMEQDLKKICEGHASKTDVVKDIVEKYRKYWHKTNACKNTLLQVYDRVKASM
(1377) DNA topoisomerase 3 [Saccharomyces cerevisiae S288c]
3
MKVLCVAEKNSIAKAVSQILGGGRSTSRDSGYMYVKNYDFMFSGFPFARNGANCEVTMTSVAGHLTGIDFSHDSHGWGKCAIQELFDAPLNEIMNNNQKKIASNIKREARNADYLMIWTDCDREGEYIGWEIWQEAKRGNRLIQNDQVYRAVFSHLERQHILNAARNPSRLDMKSVHAVGTRIEIDLRAGVTFTRLLTETLRNKLRNQATMTKDGAKHRGGNKNDSQVVSYGTCQFPTLGFVVDRFERIRNFVPEEFWYIQLVVENKDNGGTTTFQWDRGHLFDRLSVLTFYETCIETAGNVAQVVDLKSKPTTKYRPLPLTTVELQKNCARYLRLNAKQSLDAAEKLYQKGFISYPRTETDTFPHAMDLKSLVEKQAQLDQLAAGGRTAWASYAASLLQPENTSNNNKFKFPRSGSHDDKAHPPIHPIVSLGPEANVSPVERRVYEYVARHFLACCSEDAKGQSMTLVLDWAVERFSASGLVVLERNFLDVYPWARWETTKQLPRLEMNALVDIAKAEMKAGTTAPPKPMTESELILLMDTNGIGTDATIAEHIDKIQVRNYVRSEKVGKETYLQPTTLGVSLVHGFEAIGLEDSFAKPFQRREMEQDLKKICEGHASKTDVVKDIVEKYRKYWHKTNACKNTLLQVYDRVKASM
(1378) DNA topoisomerase 3 [Saccharomyces cerevisiae S288c]
3
MKVLCVAEKNSIAKAVSQILGGGRSTSRDSGYMYVKNYDFMFSGFPFARNGANCEVTMTSVAGHLTGIDFSHDSHGWGKCAIQELFDAPLNEIMNNNQKKIASNIKREARNADYLMIWTDCDREGEYIGWEIWQEAKRGNRLIQNDQVYRAVFSHLERQHILNAARNPSRLDMKSVHAVGTRIEIDLRAGVTFTRLLTETLRNKLRNQATMTKDGAKHRGGNKNDSQVVSYGTCQFPTLGFVVDRFERIRNFVPEEFWYIQLVVENKDNGGTTTFQWDRGHLFDRLSVLTFYETCIETAGNVAQVVDLKSKPTTKYRPLPLTTVELQKNCARYLRLNAKQSLDAAEKLYQKGFISYPRTETDTFPHAMDLKSLVEKQAQLDQLAAGGRTAWASYAASLLQPENTSNNNKFKFPRSGSHDDKAHPPIHPIVSLGPEANVSPVERRVYEYVARHFLACCSEDAKGQSMTLVLDWAVERFSASGLVVLERNFLDVYPWARWETTKQLPRLEMNALVDIAKAEMKAGTTAPPKPMTESELILLMDTNGIGTDATIAEHIDKIQVRNYVRSEKVGKETYLQPTTLGVSLVHGFEAIGLEDSFAKPFQRREMEQDLKKICEGHASKTDVVKDIVEKYRKYWHKTNACKNTLLQVYDRVKASM
(1394) DNA topoisomerase [Streptococcus macedonicus ACA-DC 198]
3
MKYLLLAEKPDQAKKYANALGNPKNDKGVWRVQSSVLNAEVIVAPAVGHLVERINPYTNFENWEMANLPALPEGFSYEPKKDTIKRFKAIKKAVKEVDAIIIGTDPDREGEAIAYRILELIPGALRKIKYRLWANSLTKKGLEQAFSSLKNPKDSVNYFHEADARGDADWLVGFNLSPFVTIKMKEEGYLDKKDHSMSVGRVQTPIVSLIVRNDEAIENFKPSPYWQLKLIDPEAKVTFGNDIKYQSKAEAEQMLQQLANIAVVKTVTSEEKVQEAPKLYNLTNFQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFAYLVEHIEDYQKAINKQLETPNRSPRKAYVNDKKVLEHYAIIPTETIPDLSELSDDEKLIYQKVVFRTLLMFTPDYRYQSTSVILDNHGLEFKATGAVTKDKGWRNYLAVKKEDKELPNYQEGQTITVECKLLEEMTKPPTRITEQILLKKLLPKYNLGTSATRDGMIDLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVDKIKWAITKQIEKGKQI
(1397) DNA topoisomerase [Picrophilus torridus DSM 9790]
3
MTLNLIIAEKMDAGRRIAYILSKKTSKQKRSKGSFYIEFESNNERNVLVPLSGHVLEADFPSDFKDWLKSDLNLLIDSRIVYNVKNQRAINTLKNFKDADNIIIATDYDREGELIGTEVLKFLNAKNIKRAKFSALTEKEINDAFSNTINVDYNLADSAQAREEIDLIWGAVLTRFFSIASNRLWKDFISVGRVQTPTLGLIYKREMEIRSFVPEKYYKIKITFNKNRDFDAYYNNELKDRKTAEKIFSEVKNMPGRVKSFDKEEYYIYRPAPFNTNEFLREASYLGISPARAMNIAEKLYMQGLISYPRTDNTVYNKSINLKSIVEKLKKSEFSMEADLVLSQEKILPSRGKTEATDHPPIYPVSVPSKELTGDYKKIYELIVRRFLATLYKNAVAVRSTALIDVNGHDFISEGNIIKENGWYDIYKYKSYREYFVPDLEKNEVLNGRDYELQEKETEPPRRYDVSSLLKAMESLNLGTKSTRHDIIDKLYSRNFVTGNPVKITPLGEGFIKSIIDTNPRISEPEMTAELEMDMDKIASGTKTKDDVVNESRRMLHSVLNDFQGRTSEINKTINDYLNTGESLGRCPLDGNELFLIKYRDHYKIKCGDENCRIDFNIYSNGRIQLNDSKCPVCSLPMIKIIRKGQSPEVKCIDPACDYNKEKDIYGTCPADGGNLVLRQSRYGKRFLGCSNYPKCTVTYPLPQKGILKKTDKKCQYCGAPIIVLINGRRHFEFCPKIDCEFNRGGKIEKNKV
(1414) DNA topoisomerase III [Burkholderia vietnamiensis G4]
3
MKRLFIAEKPAMARDIAKHMGGRMTKKVGYVEVDMGGGVVNIVASCIGHLLKQAEPADYVKDLEFPGTFADLPILPDQWKLQIAEKKSAQVTLLRRLLRECDEVVNAGDPGREGQLIIDELLEFCGNRKPVKRILLNSLDSATVKRELANLQDNTRFKPIYQAGLGRQRADWLVGMNLSRAYTILGRRAQYRGVLSVGRVQSPTLALVVRRDRAIETFVPRDYWAVKALVRVDGGEFWARWKKPEPAPEWLDEEGRIVVQAEAERIVRATQGQTGQITRFETKPGKEEPLLPFSLATLQIFASAKWGYSAKEVLDACQYLYSEKKCFSYPRTDARHLVVALQAQIPDTLSAIAQTLSMLSPACAKADSSILGKAWDDSKVGEHYALIPTSEAADFASLTPIQQNLYRAVAQRYITLFYPDCLIERTSVEATVAQEVFAASGRVVKSEGWREVYAGEAPEPETPDANGKVAEEKEDEQRFPQMSLGQSAKAAQTVSEQKRTKPPTRMSDSSLLLAMTNVHQLVKDPQLRQRLQSSKGIGTSATRAAIIENLVEKGLLLREGKTLISSSAARVLIDALPATLLDPALSAMWENALDLVAAGKAPLDLFMQKQEAWLRQLLEKAQATGLGALSDAPLANANAGGASRGSGSGSRAGSSSGGSRSAGTSRSSSGSTASSRSAPQTGAGQNAGSGSRTPAPREIGHESSKTAPSAAVKACPECKTGKMVVRQARSGPSAGKPFLGCTNYPRCKHAERMPEKEPAR
(1419) DNA topoisomerase I [Coriobacterium glomerans PW2]
3
MVLVIAEKNIAAKKIAQLLADGAPKTDKVYSTQVYRFSVDGEEWVSMGLAGHILAPDFPEAILFDAERGWYSLTDDGEILPADVPDGLARPPYDSKRRPYLPDGINIKSWKVDSLPYLTWAPVVKHPAEKEIIRVLKNLAKKADSIIIATDFDREGELIGADALSQVREVAPDVPVARARYSALIKGEVCGAFDNLVELDRDLADAGESRQHIDLIWGAVLTRYLTLAKFGGFGNVRSAGRVQTPTLALVVARERERLAFVPEDYWQIRGIGASGDTAFKIAHATARFTDEQKAKTAFAHVQGKTSGTIVKVATRARKQAPPAPFNTTSLQAAAASEGISPARTMRIAESLYMSGLISYPRVDNTVYPPSEDLAAIVSGLAASSPALAPVCKKVLAGPMKPTRGKTETTDHPPIHPTGQGSPESLDGGQRKLYNLIARRFLATLMGPATIENTKLSIDVAGEPLTASGDVLVTAGFREAYPYGLKRDEQLPPLSAGDVIEVRDLALEAKQTEPPARYSQGRLVQEMEKRGLGTKSTRASIIERLYQVRYLKNDPIEPSRLGMAIIDALAAYAPRITTPDMTAELDGDMTKVAEGADTEAHVVDHSRALLAGLIDNLIDHKDDLGEAISDAVTADAKVGVCPTCGRDLVMKASAKTRGNFIGCMGWPECDVTYPVPSGVKLEPIEGDDGVCPECGAPKIKCKPFRSKAYEVCVNPRCPTNYEPDLKVGECAVCAEAGRHGDLIAHKSERSGKRFIRCTNYDECAVSYPLPARGKLQATGETCEHCGSPIVVVETARGPWRICVNMDCPGKEKRPARGRRGTAAASKPAAKKTAAAKKSAAKKSPAKRKPAAKKTAAAKKTAAAKKSASSR
(1439) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1440) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1441) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1442) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1443) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1444) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1445) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1446) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1447) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1448) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1449) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1450) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1451) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1452) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1453) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1454) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1455) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1456) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1457) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1458) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1459) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1460) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1461) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1462) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1463) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1464) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1465) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1466) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1467) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1468) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1469) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1470) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1471) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1472) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1473) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1474) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1475) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1476) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1477) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1478) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1479) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1480) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1481) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1482) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1483) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1484) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1485) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1486) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1487) DNA topoisomerase 3-alpha [Homo sapiens]
3
MIFPVARYALRWLRRPEDRAFSRAAMEMALRGVRKVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVTHDHKDGIVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCPVCQPHPVYRLKLKFKRGSLPPTMPLEFVCCIGGCDDTLREILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQHPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCNCGQEAVLLTVRKEGPNRGRQFFKCNGGSCNFFLWADSPNPGAGGPPALAYRPLGASLGCPPGPGIHLGGFGNPGDGSGSGTSCLCSQPSVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENTAPGTSGAPSWTGDRGRTLESEARSKRPRASSSDMGSTAKKPRKCSLCHQPGHTRPFCPQNR
(1488) DNA topoisomerase [Streptococcus infantarius subsp. infantarius CJ18]
3
MKYLLLAEKPDQAKKYANALGNPKKDKGVWRVQSSVLNAEVIVAPAVGHLVERINPYTNFENWEMANLPALPDGFAYEPKKDTAKRFKAIKQSVKEVDAIIIGTDPDREGEAIAYRILELIPGALRKIKYRLWANSLTKKGLEQAFSKLKNPKDSINYFHEADARGDADWLVGFNLSPFVTIKMKEEGYLDKKEHSMSVGRVQTPIVSLVVRNDEAIENFKPSPYWQLKLIDPEAKVTFGNDIKYQSKAEAEQMLQQLANIAVVKTVTSEEKVQEAPELYNLTNFQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFAYLVEHIEDYQKAINKHLETPNRSPRKNYVNDKKVLEHYAIIPTETIPDLSELSNDEKLIYQKVVFRTLLMFTPDYRYQSTSVILDNQGLEFKATGAVTKDKGWRNYLAVKKEDKELPDYQEGQTITIECKLLEEMTKPPTRITEQILLKKLLPKYNLGTSATRDGMIDLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVNKIKWAITKQIEKGKQL
(1496) DNA topoisomerase 1 [Ureaplasma urealyticum serovar 10 str. ATCC 33699]
3
MQKDLIVVESPNKIKSIQSYLGDGYNVIATGGHLRELAKKSGYDPKTYDLKWEIIKTTNKKISKKQQIKAIIDLAKKSDNIYLATDPDREGEAISWHVYDLLPKKEKERVRRITFNEITQKAILKSIDEKHDIDFNLVDSQFARRILDRVIGYKLSGLVKKNLHGLSAGRVQSIALLFVVERELERRAFVKEEWYQVEGTIEKNIFVSLRKVPYDVELYNQKENGDSDLKFLHRKDAQRVIDELGDIFKVYNVDDLKITKGDVQLPLTTDKLLQMASNNFGWSANKTTLVAQQMFEGLEINNQQLALITYPRTDSKRLSDDFLLEANKFIEDNYGNDYLENFKNKKINKKEENVQDAHEAIRPVDINLKPEEIKEHVSADIYKLYNLVWNKTLAALMKVPTFNKQVIRFISNEYKFYTSYKTIRTLGYWVLDFYKKQRDELKFQPPVINVGDEFKKENIELVQKETTPPPYYTEASLIAALKNAGVGRPSTYATMATIGTTRGYINKEKGKLIPTELGIKVIQELKEAFPRVISIKFTSKMEDRLDVVANGELFWKDLVSSFIPVFEEEVKQAYTKIEKVPDEKINRLCPMCEHDLVIKRSRTNAQFIACSNFPTCRFTESLEKPEILDELCPTCSEPLIKRKNRKNKYFIGCTGYPQCNYIRNVNESNNDKNNSDQE
(1505) DNA topoisomerase [Methanococcoides burtonii DSM 6242]
3
MTTVVFTEKNKAAAQISTILSGGSAKRSIVDGVSVYEFQRDGSLWKIMGLAGHIMGYDYPEEFHNWRDVDPAALLDTDPVKQINKASFGSAILKISKGADLLVLACDFDREGENIGFEAKSIAEKVSDATVKRARFSSLSKSEIEKAFNDLVEPDENMAMSAEARQILDLKMGASFTRFVTLSVRERARTKGVLSIGPCQTPTCGFVYERELAIRKFDSRDFWKIEGVFTGKGADIIGVHRGGHIYDKEKAAAIFKKLKGCKTAVISKKTVKEMNTNPPFPLNTNEFLKRASKYLGVSPDQALEIAEQLYLSGFTSYPRTETNMYADDMDFASILKGFTKGDYQDFALLLLSQKAIVPRNGKKDGHDHPPIHPIKAGSRMEVERAIKMPRAWDVYDLIVRHFIANLLPPAVFEKTRFEITMEDELFDSTGSIQKNAGWLAVYPFEKPQDKILPALDLGEVLDVKKITNIKSQTTPPKRLTEAELLTLMDKHGIGTKATAPSHIETNKKRGYFEVKGKTIAILDTGFTLMDALNSSVPILVKPDIRSSIESLIQDVEDGNKKFELALEEGTSLIKEMYSQLLSNRDLMVTRIAGTITDEAVEADKKSHIGKCNECERVLRIVSTDKGRFVGCTGYPQCKNTFPLPKTGALAVQRSRTCKKGGAAVLKVGSKYFWAVGIGPCFSCDMEKECYPPEIVGECPACDGQTFLITTKDSRFLGCTKRCGHTQSVPKNGRLTITDKVCEGCGWRLLRVKEQGKDAKEYCANRKCEVAAQMRSSYRKK
(1507) DNA topoisomerase [Eubacterium siraeum 70/3]
3
MIVIYAEKYSLGRTIAEALGAYKKTVNPKEPSIAHWSLNLNGEEAILCHGAGHLCGLAPAEDYNESYKFWSFDNYPIIPEHFITRVKDNNYSRLAYDYVKQFFDKADLIINATDADREGELIFAYLYEVLHCTVPYKRVWITDLTPFKIRKAFAELRPAKDMKPLENAGRIRSATDWLVGINTSVAATLKFGGTDNVFACGRVKMPTLAMIVKREREIRNYVKKPFYKIVANIEATDGAKFTAEAADKYDTETAAKAVIDEIKLNTAKAIKVEVLQKQTAAPLLYNTTHLLADLSKCTDLTIDMLTKLVQSLYENRLITYPRTSSEHLTDAMKDETVKIIKLLFEMPEFAKYAIPVDNFAPCTRRHYDDSKVDSHTAITPTALVPNDLSGMSENERKAYTLLALSIIRTVYPKAVTENVKAVFQIDNQLFTATGTNIISPGWFAVDATPKVIGLPEIVKDNDYKVIGFDVKEGQNEPPKYYTDATLLTAMELAGDNIEDEQTRNLIKLEKRGLGTAATRQGIIKELYEKGYIARRTKKNGNMIKGIMPTEKGMYIIDALEKTVPDMLSVDMTSDMEMELDKIARGKSDGNDFLNNYKKLVAKWVELIKNSDTSAMAGNTLICPLCSKPLIKKKVGWCCTGYSKDNPDSCRFYIANEICGKKISDVIAKELTLKRSTSIIKGFTSQSGKTFDAKLTIKADNTIGFEFPERLKCPVCGKEMIKSSKGWVCTGYKNGCNFFIAGTICGKCITDTIATMLCANKRTRIINGFTSKSGKAFSAALIVKDGKIDFDFPAQSQKRSK
(1509) DNA topoisomerase [Streptobacillus moniliformis DSM 12112]
3
MKLIIAEKGSLGRNIAQAIGIIKKNEGYIECKNDFVVTNAIGHLLELKQPKDYEENVGKKWREYTLPFIPNNFVYEVKDDVGVKKQLNVIKGLMKKADLIINCGDADREGQIIVDNLLKFNVNKAPVKRLWLPEQTEETIRKELNNLKDNSDYYNLQQEGYARAYMDYLLGHNLTIMFTNLSGKMLNAGRVLVPIVKYIYDRDKEIKNFIVEKYYSVENENIVKLISSNKFKTIEEAKIYSNKLNSKKAKVIGIDSKEVKKQSKKLFSLSTLQSELSKKYKINFANSLKIIQELYEKGYLTYPRTNTEYLSENEKGKVNDILGVLNNEDLEFKDSKKIFDDSKIESHSAITITKKIPGDLSVEQDKVYKVVYNRFLSNFVKEDCIVSETTMIIKVDEEEFKLKGSIIKQLGFMKYEPKEYKDKLPGLNLNDEFDIEFRSVEKETTPPFKVNESELSKFLKNPFKKEKNVSEEEMYKDILEGIEIGTEATRTGIIDKCVKIGYLTLDNGVFDVTELGIFFINKLIEYDINLFKEKSVEFSKLQKKVYKNEIKLEEVIERVREELRAIVERTKDIKAPKFEEKLKDGVIEINTKNGKCFKGVFNGEEVWLYPNMKYFDNQLKITKSTAEKLCKGKSVEFELEYKGKKYMQKLKIEKNERYINFVK
(1520) DNA topoisomerase 1 [Methanococcus aeolicus Nankai-3]
3
MTDLIICEKPNVSKKIADALGKPKKKSNDGVPYYEIERNGKKIIVASAVGHLYTLEEKKSDEKGKNKGRNSFGRYPIFDIRWVPASTIKGKEYVQKYINTLNKLSKKSNDYYIASDWDIEGELIGYHALRYCCNEDNAKRMRFSSLTKKDIIKAYEQPDNIDFGLVDAGDTRHRLDWYYGINMSVALMQCIRSVNRWHTMSTGRVQGPALSFLVDRELEIRKFVPVPYWVIDANLKDGLIAIHEKDKFWDEKEANTIYNKIKDEKEAIVANVKKTKKTIKPNPPFDLGALQREAHRIFKFSPKKTQEIAQKLYEKAICSYPRTSSQKLPKDDNYINDILNKVVNHNIYGKYAKSIIEEGRKPIEGKKDDPAHPAIHFVDTPKEELPPEEQKLYDLIVRRTLAVFWDNAEREYSNISLDIGGEIFKLSGSRTIKEGWHEIYYFTKFDETELPALRKNNKIVVEKINIEEKETKPPKRYTMSSIIKELENRELGTKSTRADIVEKLVKRGYLIEDNSLTVTDLGIGVIEVLKKYCPEIIDEQMTRELEKKLDRLQKRTIKKETVLKDAEKKLTAILNEVKKKEKEIGAELVEKVDATNKTLQTIGKCECGGDLGIIRIKNKRRFVGCSNYPECTIAYPLPAKGRIKIPNEVCEVCGKPMLLIDNQKLCVNTDCPSKISEEDKKELEKLEKSEKPCPKCDGTLTVKKGVYGVFLGCSNYPKCKYTEKLHSKKEDSEITVVGECPDCGGDLVIKKGRFGEFIACSNYPKCKHTEKIKKDGKSNAKATKTEKTETKTTKKKSTKGSTTKEKKKPDNSNEVGECPDCGGDLVIKKGRFGEFIACSNYPKCKHTEKIKKD
(1521) DNA topoisomerase [Veillonella parvula DSM 2008]
3
MRLFIAEKPSMAREISKCLPENKNIQKRNGYFIQGDDVVTWVVGHVLHQAEPGDYDDKYIRWRPQDLPIVPAEWKLLVTDSSRQQFEIVKDLIDKADVIVNAGDPDREGQLLVDEVLYYVGNTKPVQRILLNALDEKSIRSALDDLRDNKDFHNLYQSALARARADWLIGMNLSRAYTLSERYKGNKVTLPIGRVKTPTLALVVRRERELAAFKPVDYFTVKVLYNHPNGVFWATWQPTDEQKGLDPDGRLINKAIADSLVEQLQSGPDGVIKAVTKSKKKDVQRLPLSLSSLQVLAGKAFSYDPQTVLDTAQKLYEKKLTTYPRSDCEYLPPNQYDDRNAILNNLQNAGDERLAQWAADADRSIKSRAWNEKKITAHHAIIPTTVACNINSLSQEERNIYFLISQAYIAQFYGEHIYEQTKIVVEQCKEEFVANGRVVIEEGWKLLYKRHKSKSTTDNDEPDLTDERGAESDPKKEIIEETDHLPAVKKNDTVLYTDSSVEAKQTKPPSRFTPSTLLQAMKEIHKFVKNEDLKKQLKAVSGIGTEATRANIIDELISRGFMKTSGKKQVLSPTETGYLLVDALPEELLYPDETAVWEERLALMSEGEDTLDSFLADQIKFLKLLIDKLGFDKVINSDQMMPNVVRTITSQNRKRPMDSESVDLSSLPVCPKCKKGRLQQRNGKFGAFLGCTNYPTCKHTQPVEGDTSSVEGNIEVSDEDKQYKCPRCNVGYFVKQEVRGRTNWICSNRSQCKTQCSDVDGVPSIYVNKSNIT
(1532) DNA topoisomerase 1 [Methanosarcina acetivorans C2A]
3
MHLIVTEKNIAARRIAAILAPKSPKKERVSGVDVYRYELGKGKSRQETAVVGLSGHIVGIDFQKEYNNWQKVDARALIDAEITTTPINRKIVTALRTLGKEADRVTIATDYDREGELIGVEALNIIKKVNPEVPFDRVRYSAITPKAIDAAFTNPTSVDFDLADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLSVGRVQSPTLSLVVDREKERNIFVPTPYWEIHVELETKAGETFSAQHSTRRFLDKEEATAVFKKLGKKAELKEIEKGTKSDLPPTPFNTTGFISAANSIGLSPANAMRIAESLYTNGYISYPRTDNTVYPETLDLRAQIEIFTEGPFKEFADALLEKAELVPTRGKKETTDHPPIYPASLAKESELKEEEWKVYELVVRRFFATFAGPSTWETMRLRLEINAEEFRANGARLLEPGWRWYYPYNVPEDRLFPELSEGEILKVIKKEMLDKETQPPGRYGQGRLINIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVVETLEKYSPTITKPDMTKLLEENMDLIAEGKIKEDTVLEESREMLQQVFSELDKNRDKIIESLQAGLREDKIIGNCSLCGNELMIRRSKRGSRFIGCSNYPNCTFSLPLPKSGQIVVTDKQCETHGLHHIRIINAGKRPWDLGCPQCNFIEWQKTQKEKQAQQPKKEKPKTIKDIEGVGKATAGKLEEAGITSVEALAEADPIELAKTIKTSVKKVKTWQISCNGGIVEDL
(1534) DNA topoisomerase [Bacteroides salanitronis DSM 18170]
3
MYHFLFPYGKPVWEEIKKTEFIMIAILTDKPSVGKEIGRIIGATKVKNGYVEGNGYMVTWTFGNMLSLAMPKDYGIQRLERDDFPFIPSEFGLMVRHIRTNNGWIPDIDAVLQLKVIEKVFQNCDTIIAATDASRDGEMTFRYVYQYLNCTQPCFRLWISSLTDESVRKGMEELKPDSFYDSLFLAADSRNKADWILGVNACYAMCKATGLGNNSLGRVQTPVLAAICRRYRERENHISSDSWPIYISLQKEGILFKMRRTQDILNKESAVMFFQDCKLAQKAQITNVSHSIREVLSPELLDLTQLQKEASIRYGLTAPEVYDIAQSLYEKKLISYPRTSSRYLTEDVFDSLPPIMTRLLSWELFPVSEKTSSIDIYTLPRHVINAKKVNVHHAIIITGIHPGNLSEKEMLVYRLIAGRMLEAFMPPCRIETTSVEAICAAQKFKAEHTRVIEAGWHDVFMRSDTVSQSGFSVNELPWLDKGDTLKVCGCNLVHKKQLPVSPFMDAELVEYMEQNGLGTVSSRTNIIRTLINRKYIRYSGKYIIPTPKGMFTYETIRGKKIADTSLTTDWEKQFAELENGMTTGQEFLDRIKVLAKEMTDDIFNTYSQRKE
(1541) DNA topoisomerase 1 [Mycoplasma penetrans HF-2]
3
MDKLLIIESPNKIKTLTKYLGKDYEIIATIGHIRDLNQFGMGFDADFEPKWVIPSVKKNSKNKNEVSKKEIVEKLKKSASKAKEIYIATDPDREGEAIAWHVYEVLDAASQKKCKRITFNEITKNAILESLNHKRDIDINWVQSQFARRIIDRLIGFKLSKLLQTKLKADSAGRVQSVALKFIEDREKEIRNFVAENWWTLDVMLEDNNSLILKSIDPNLKNIKLSEKKFSTSGLDIADEESANNLLNALDKKFKVKSIEEPSFYSSYPKSPYKTSTLQQDAINKLGWNSKKITLIAQHLYEGVEVDGNQIALISYPRTDSLRLSDTFVQSAFKFIEETYGKDYVGKYQVKSSANDANTQDAHEAIRPIDPYLTPQELKNKISKDEFALYQLIYNRTVASLMAAAKFKKVTIKFDNNNCEFYTFSRECLFLGFKKLYVEDNEDEENKLIDLNNYPVGKEFKSKVMEVKKHETQPPQRYTQATLIGDLESAGVGRPSTYSSMANIALERGYAVTDKKAYVMTDIGKIVVDQLEKFFPDIINKDFTKKMEEHLDQIASGNEEWKSWLKKFAPGFDEEVKKAYDTMEKISDEKVGRECPKCGKDLLYKRARRGGSKFIGCSGYPECTHLEPLEKPEELEISCPECGSKLLKRKSKRQQVFVGCSSWPKCNYIISDKLFDKHMKETPDKPLPSKKELEEIRAARLPKWKKN
(1570) DNA topoisomerase 1 [Methanobrevibacter ruminantium M1]
3
MHEVIISEKPKSAEKIAKALSPNAQKKKYNRKINYWEFEENGKKTTVLSAVGHLYSLTSASSRDRLGFDLTWVPAYEVEKQKYTRDYINAIKKLSKGADKFVHACDYDVEGTLIGYNALKYACGNNAEAKASRMKFSTLTKKDIVEAYNTMRDIDIRQVDHGIARHMLDYYYGMNISSALMKAVRASSSRFISLSAGRVQTPTLSILVDREKEIQSFVPEPYWMIKAKSDYDIIADHVEGKIFDEERAKKIYADCQGADADVTSVKVTESIRKPPIPFNLGGLQSEAHTVFGFSPKRTQVAAQNLYVGGYTSYPRTSSQKLPESLDFKNIFAGLAKDPEFKKHIFDLPAKLKPNEGKKTDAAHPAIHPTGVLPSNLSADEAKIYSLIVYRFISVFSENSKLETMKVNLKVADEKFTFSRKRVSYEGWLKHYPFKKQENDAFPPINKGDQLKIHKILVEEKETKPPARYNEASLIKELEKRELGTKATRADIVAKLYDRKYIEGKKIEVKPLGINIIDTLNEYCKDLTSEELTREFERELEGIDTDKYTKEQILENGEKEVKTILAEINQNKKQIGEKLYGAYQETNVVGECSCGGKLIKRYSPRTKNTFVGCSNFPKCKVTYSLPKGANMLKKTCPTCGLPMISIKKASGKGRDHVCLDSNCGKDVSRRQAPEVVGKCPECGKDLLKRSGRYGEFVGCSGFPRCRFTCSVDELNNLGKDKNKEDVKENKGVSKKIVRSEAK
(1577) DNA topoisomerase 1 [Acaryochloris marina MBIC11017]
3
MSRLLIVESPGKIKKLRSILGSGWQVRASVGHIRQLANTGTGNLGFEAKNGQITCSYEPRDDRAKKTIADLKTAAKQADEIFIASDPDREGEVIGWHIAQVLGIKKPKRVVYQEITERAVQQAIAHPKSLDMDLVEAGRCRDCLDKLVGYRGSPLIWRLNNGAKSVGRVQSATLHLICQREREIQVFVPQDYWSVFVEYSEGFKAFYHGSMTGNEPDETTIEDAGSEAKTEESTRVTSQAAADALVEIAQAHPHHILSIEGKITPKKPPAPFTTSALQQAAGSRLKFSPEQTMQVAQKLYETGLITYMRTDSVILSPDYCAAAKKWLEQNDADNVPKKVAKQKGGKQTQEGHEAIRPTDIFKPSAELKQFLPEEQFKLYVLIWTRALASQCKPAQIRKTIVISQSGEVQWKAKGNLVEFKGYSKYWKDIKADTELPTLQPQQSLTLAQADSQQKQTQPPARYSEPKLVQLMEKKGIGRPSTYAPTIKTIKARGYVDLIKGKLQPTQIGMEVDQFMGGALPELLEAEFTAQMESSLDAIAQGNQEWQNYLIDWNRSYFAPALAKALKELPEPTGNYGGKVLQKSRTKCPGCSHPMSKVPSKKVKKKYFLKCENGCTADNGRGLVMFWSDRDKNWQVPQAKSDQPTPPAELTDYPCPACQQKMEIYSYHKDGQTKQMLRCSDPKARSDKKHKNAVYFQSKGRWWSPKYGELE
(1579) DNA topoisomerase 1 [Thermococcus sibiricus MM 739]
3
MTTLIIAEKPNVAKKIAYALAERKPIRKTIGKVPYYELTRDGKKIIVAPAVGHLFSLAPKERTYGYPVFDIDWVPVYLAEKGKSYTKDYIKALKELAKQADEFVIACDYDTEGEVIGYTALKYACGVEPSKAKRMKFSALTKQDLLRAWYNLEPTINFGMADAGITRHILDWYWGVNLSRALSSAIRKSSGKWHVLSTGRVQGPTLKFLVDREKEIENFVPTPYWVIKMILEKNGEQYTANYEKDRILNEEEAKRIVEEAKKGPAFVEKIEITQQKRSPPYPFDLGTLQRESYSAFGYSPKKTLEIAQKLYEKGYCLHPDSLIPTPKGVKKIEELPKEGEVFALDFDLKLSRARYRLLERDADELMYKVTLSDRTELYLTGDHPVLAYRDDRLIFVPAEELKDDDQVVLLINPWKFQSASETPKLFDFILKNASSMKDYILYDQSFGSVIRNRIKKAGLKVEILWKFKIKEPTYYKYLRGKMPVPVFKFLIERGVISKEEAREVFKGFSYSTSLSAVSFEFNEDFWYLYGFVVGDCHLDKRGQITIGARDRTEETIMAIQEVANSIGVRFAYDSRYKIIRLGSKSLVRLFELLGCPYGNKMKIFEIPGEVMAKPGWMASFLAGYYDADSHIGTKSTGGRKSLSPQIVLTSKNRRAIYTVKLMWQLLGVGTYLWERKDKNGNLMAYELKVYSRDSLKFYEIMKDHLRVKRCDLEKVRNAAIRKRKSYSHHYSVLKVTDWNGKLKSNKKLWKEFDISNQTAHGRGISLDKLRRIRDYLTDEDLRRIATGDVYILGIKSIEKFHYCGKVYDLVVEDYHNFIANGVVVHNCSYPRTSSQKLPKNLNFRSIIQNLAKIPEYKPHAHELLGKGILKPVEGKKDDPAHPAIYPTGEVPKPGDLNKDEQNLYDLIVRRFLAAFAEPAIRESMKIIINSNKHHFILNGSRTIKEGWLKIYGKYVKFDEVILPKFEKGEKVNVIQIKKEKKKTKPPARYSPASIIKKMEDLGIGTKATRAQILETLYSRGYIEGKKKIKVTPLGIKVIEALENNVPDIISVELTREFEQKMEEIMARKLKKERVIEESKTALIKVLKEFKNKEGEIGKKLLETFLENEKNKKSKRKNVKELKPEEEKVIQVEADFENKGKEKIIVGSCPKCGGDLVVRYNRRTGKRFVGCSNWPNCNVTYPLLQRGQIIPTGKTCSECGNAPIIKIKERNREYEVCLDMNCNKNRKKK
(1585) DNA topoisomerase [Treponema succinifaciens DSM 2489]
3
MLIIAEKPNVAKEFADALSCRKTGGIYSGKDTTITNCKGHLFNLEEPKHYTSEIFPIIPERFDYRENPKTSEQTKIVISLLKKHRNEEILIATDADREGEVIARECLLMAGITDFSRIKRFWVSQALTTEVIKDGIRNAKPLSEYNVLSAQGFARQHADWLVGMNFSRYISRAANTKLPVGRVQTAILNAISERCDAIKNFRSEKYFEHYGIFRPTRVGSGNTECTGIYFENNTTKFPDDSRSQKLKECIGKKAVLKEKREEEKSIEPPQLYNLNSAQKDAFKFFGYSANETLSIIQSLYDDLKCVSYPRTPSKVMGSGNVELCRNVFDELCKAYPKYRQLAASEDFSVSNKRCFNDKKLEAHHALIPLKALPENADEKQMNIYTLILERFMAAFLPEAKYIQQVYILEVGGNTFKISGKKTTESGWKNFTDILSDRHVSVQSKETESEEQSLDGIDWNSLVLSKTETKEKWTKPPKYFNEASILSFMENPKPDRHVSVHNEQNEKLTGLGTPATRHTFIPKLTANGYIELQNKNFICTRLGETLLSALRNSSLKQIADISATTQWEKELAENPETFEKKMKDFVRQAVSTEIKIDHIGITENEIKCPACGKPVKESAKNWFCTGYKDGCKFKSLWKETRGTKFAKSDIKALCEGKKTSLKKCMKKDSGNYECRFILNKENSWEIEPLFEKRNKK
(1621) DNA topoisomerase [Thermoproteus uzoniensis 768-20]
3
MLIVAEKRSVAQAIAKYLGGTYSSFKVSGVSAYRFKYDGASAVSLGLSGHILDFDFPQEMNRWGAVDPARLFDEAVVLTPRPETLKYLYALRSLARGQDVVYLALDADSEGEAIAYEVVLQVRVVNPAARFKRVRFNAVTKAEITRAFARPVDLDLKVVEKVFARMASDLTIGAAFTRLLTLSVRREDSSALPFGKFLSYGPCQTPVLGLVVSRELERLNFKPEEYFVVRAVVGTGGGEVEMRSKPFKRREEAEAALAAARKAEGRIAEARYEKAEVRPPVPLETVELERRASRWLNIRAKAALDIAEELYRLGYISYPRTETTIYPPTLDLRAILEELRNTPFGQYAEDLLRRPFTPTRGRSDDGAHPPIHPTRGAGRGEIEARLGQRGWKIYELVVRHFLATLSPPAVVERQRIAAAFGPLVLEAEGRKVISKGYWTVYPYEEEEEEPLPYVKRGDPAELLSAKIERRLTEPPPRMTESELLKLMRKYGIGTDATMQDHIHTNVLRGYMRIAGGKCIPTPLGMSLATALMKHARPIIDPEVRSKMEAALQEIAAGRMDPSKVVAAIREEFKKYYKFLEDKKAEIAGELVKALKEGPDRKQ
(1625) DNA topoisomerase [Fretibacterium fastidiosum]
3
MRLFIAEKPSLARAIAAVLPQPQRASRLYIEAGNDVVAWAAGHLLEQAMPEQYDEKYKRWNLADLPIIPEEWKMLVKKESRDLFDNLKTLLKKADSVVNAGDCDREGQLLIDEILEHCKYKGPVQRILISDTNPDAVKKALAELKPNEDFRGDRDAARARSQADWLHGMNMTRLYTKLAEKNGYDGGPLRIGRVKTPVTALVVRRDLEIESFVPKPYWTLQAQIQVKEGAFWAGWRPKEEQTGLDEEGRLVDKATGEELASRLKGKPAVITKYESKKQSVKPPLGYSLPKLQMAASRKHDLSPSRVLEVCQKLYEQGVLTYPRSDCEYLPEGHQDEAEKVLAVIDALSSLKRPDELNTARKTPVFNGKKVEEHHAIIPSASCRASKPLEGDEPLIFELVARRYLVFFMPDHEYMQTSITAEVEGETFVASGRRVLAEGWKAVERNDEPEKNDDKEDREEEQAALPVVSEGEKGECRDTKLQEKQTKAPARFTEASLLRAMNEVHKFVADPKVKKILRETDGIGTAATQAGILKDLITFGQLQKQKKQLISTPAARSLIQALPEAITLPDLTALWETKFRAIKEGTLSIEDMMEQMATTIRESIAQAGSVSVQGSGEKKPVKATKKTAPKAGKGDVKCPKCGAKMVLRNGKNGPFWGCGNYPTCRATADDDGGKPVFKKQH
(1651) DNA topoisomerase 3-beta [Drosophila melanogaster]
3
MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPEVTLEWARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIAERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGDIQTPRKGKDAGDHPPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTKVMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDETYALPIGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLGGCNTCTNANCPHSLNTLGISSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSDKSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPVRSGGGFRGGKAGRGGGGMGGAAFGSGGAVTAGGGPNAGGGVRGSRVAKDKMGQLASYFV
(1652) DNA topoisomerase 3-beta [Drosophila melanogaster]
3
MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPEVTLEWARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIAERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGDIQTPRKGKDAGDHPPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTKVMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDETYALPIGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLGGCNTCTNANCPHSLNTLGISSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSDKSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPVRSGGGFRGGKAGRGGGGMGGAAFGSGGAVTAGGGPNAGGGVRGSRVAKDKMGQLASYFV
(1653) DNA topoisomerase 3-beta [Drosophila melanogaster]
3
MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPEVTLEWARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIAERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFGEEARSILGDIQTPRKGKDAGDHPPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLIDAGFTKVMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGIGTDASIPVHINNICQRNYVHIENGRKLMPTTLGIVLVHGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDETYALPIGNVKVYREFKCPLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLGGCNTCTNANCPHSLNTLGISSCVECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSDKSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPVRSGGGFRGGKAGRGGGGMGGAAFGSGGAVTAGGGPNAGGGVRGSRVAKDKMGQLASYFV
(1660) DNA topoisomerase [Vulcanisaeta distributa DSM 14429]
3
MIIDSLVVAEKDSVAKAIAKYLAQGSISVKKVYGVKSYWFTRGGRQWVSIGLKGHMMDVDFPEELNKWHSVEPSKLFDAEPILVIREDTISYVRALSRLGASASVVYLALDADSEGEAIAYEAMLVIRNANPRAVFKRVLFSAVTKSDIIEAFNSPTSLNPGLAKRVFTRMILDLTLGAVFTRALTLSVEKTDKNALARGSFLSYGPCQTPVLNLVVQRALERENFKPEKYYTLHIIVNVNGVRVTLNHDGTFKDKQEAERVLSLVRGKARAMVIIANYKEDFIEPPVPLDTIELERRASRFLNIRPKAALDIAEELYRHGYISYPRTETTIYPPTLSLRQILLELTHGEHGDYAKTLLGMSIKPTHGDSNDGAHPPIYPTRGVTRQEILRYFKNEKYWKIYDLVVRHFLATLSPPARVERQKIVVEISGHRFSVDGLKIIDKGYLTIYPFESPSEKVLPRVRVSDELSIVKAWIEERETEPPPYLSESELLRLMKKYGIGTDATMQDHIHTNVIRGYFKIRNKQCIPTPLGKAVISVLSKTGNELIDPLFRSRMEKALMEITSGSLKPDDVLFTFKNEARKIYEKFINRQREVAMELIKALKDSLSKGNKGAGGKAS
(1665) DNA topoisomerase 1 [Mycoplasma fermentans JER]
3
MNNLVIVESPNKVETIKKYLGSDYDVIASVGHIAIMSTRKGEQGLGIDLENWEPFYSLDNSKKNVIKNLKEAIAKADVIYIATDPDREGEAIGDHIVNFLIEKDRNKNKKKYYRIKYNEITKEAIQKAIQNPTELDQNLINSQKARRMLDRIIGFKLSQLMQKKISNSPRTPSAGRVQSIALKLVVDREDEINAFVPRGYHKVEAKLNETLSASIYIDKHPAAEKNWVYPEELEKVKEQISIEPINVLEVEDIKEARKTLAKYTPLKQAVLYKKSPLTSKQTQIAAQKLYEGYGDGGLISYPRTDSTRLSQHFLNIARSYIKNKFGEEYILQEIKGFAGDQDAHEAIRPTDINLLPEVAKAKFNLDNSEYIVYKLIYEHTLMSLINPPIKANKTYTFKKNKLTFKANVSKTIFPGYYLVKNENEDIEDPNYQIQQKVDVLEYQITNHETKPPARYTEGSLIEALDNIKVGRPSTFATTVAVNLERKYFENIDKSLHPTEFGRLVLSKLLDGFPDIINEGYTAEVEEQLDLIASNKTTVQPIMYDFWKRFNKTYENATETLELTAIALEYLNEKCPDDGGELIVRNNKRNDTKFVGCANFPKCHYARSVEGEENKRPKRRWFFKKKK
(1666) DNA topoisomerase [Leishmania major]
3
MPTWLNVAEKPSVAKEMAQSLSGGNCRTVPSQSRFNPVYEFKFEGKTMLVTSVAGHLMEDQFPPNTKNWSTYPFQGLFSAPITKYVRADLEPVKKNLEALAGRADTLVLWLDCDREGENICFEVMQVVQSKRPQVQVKRAHFSALTARDLLNAVHNLKLPDKRLSDAVEARQEMDLRIGAAFTRYQTVKFRHLFAAIPGVLSFGPCQFPTLGFVVRRYWQQQGFVPEDFFTLQLQHGDTKFHSSRGSMYDQVAATLIYEDMLLAAAAEGHKGRITNVQQRPSHRRPPVPLATVVMQKLAATHLRIPSERCMALAESLYQEGLISYPRTETDSYTFQESELLELVRVQISNADVAEYATAMLADIATRVRPPLRGGRDDKAHPPIHPTKAWNATQDERGRLYNLIVRHFLASLSPDAVAATTQVSAEFGGELFSTGGTTILQRGWLDIFPYERWNSTCIPNYQIGDAFQPTAVPLKKGCTSAPPHLTETHLISLMDSNGIGTDATIAQHIKTVLDREYVKREGQSLVPTTLGIALASAYESLGLASLLQPQLRAQMELAMGDIANGAATKEQVVAAAVQLYEEIFSRLMANTNAFYEELKRYLQPEVETDACAVQATVVKANFIPCGTCGRLMDLVERAGERDREVWSVRCHACNKMHRVPNGRLNTLEPVSPPHTCPLCGFLALRVANREKQTSYHVCPHCFGSPPKAWSVTTYGCVGVAASLPDVEAAAEFRCFQCTADCPLAKGLEAIGITTCIACRQHELRLRSGANGFFLSCRGYPSCQLRVSLPAAASVKPSPSQRCPACSAVLLTFDFSGRQGVPGLNMLDTICVRCDARIKDYIAVKGMPTSGANSSAVPSAAASVASTASGTYTLPSVKPSARRSVRGGGQRGGRGGDAAAANTPSGGVDPVCGCGTPAKQLVSRKEASRGKRFLTCANRQCSFFQWLD
(1670) DNA topoisomerase [Methanosalsum zhilinae DSM 4017]
3
MTTVVITEKNRAAEQIARILSNGKYKRIRIESIPVYEFSSGNQSWKIMGLAGHIMGYDYPSAYKDWRAVDPGTLLDIEPEKKVLKEEYASVIRKLANEASEIILACDYDREGENIGFEAKDIASKVSDVSFKRAKFSSLSPEEINRAFNSLVEPDVNMAMAAEARQILDLKMGVAFTRFITLSVREYVRTKKILSVGPCQSPTCGFVYERERTIRDFKPTDFWKIEALFNSGETNFPGSHRKGKIFNKDEAMSVYRKIKDCSSGSICERNVKESSVNPPNPLNTNELLKRGSNFLGISPENTLKIAEDLYLAGFISYPRTETNKYSKEFKFAEIIDEFRNGHYNDCVSLLPGDIHPKNGKKDSHDHPPIYPIKSASKKDVMKLSENPDYWNIYDLIVRHFFANLMPPAIFEKTHLAVLVKDEIFDSKGSVMKDAGWMQVYPFEKSSDKLLPRLQMGDGVNIEEISCNMSQTTPPKKLTEAELLTLMEHNGIGTKATASGHIETNKKRGYFENRGKTVSIMDRGFVLMDALNESVPSVIKPEVRARIESLIQDVESGNMDIDSAVLEGTDLIKKMYSCLSEGKDRLASKVVAAISDEAAQEDKKNFIGYCSQCNRILKIIKTDNGRFVGCTGYPQCKNTYPLPRKGALSILRSSECRRGGAAVIKVGKKYHWAVGIGPCFTCEFEKECFPPEIIGDCPECDGSMFVIQTEKSRFLGCTKRCGYTQSLPDKGRLTINEDKCENCGWNILRVKEMKKDALVICINRKCKKRYNKC
(1677) DNA topoisomerase 1 [Candida albicans]
3
MNSSDEEDIALSRLAKKSSSITSASTYEDDEDDDIPLAKKSRKKRVESDYEEDEDEVPLKKLSNGRAKKQVKTETKVKKEPKSANKSKSTSKKDTKVKKEKTTVKKESKATSTKVKEESKTQSDSQASVKSETPEEDQGYKWWEVNQEEEGDGYIKWQTLEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFEKLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVSEQVTLNLGKDAKIPEPPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFETARKLRDHVDSIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSLRYEHVTLKPPNKVIFDLLGKDSIRFYQEVEVDKQVFKNLRIFKKSPKQPGDDLFDRINPSLVNRQLQNYMKGLTAKVFRTYNASKTMQDQIDIIENEGTVAEKVAKFNAANRTVAILCNHQRTVSKTHGDSVQRINDKLKKFMWQKIRLKKMILQLEPKLKKKDSKYFEEIDDLIKEDIEHIHHTIIKRQREQAKKKLERDNEKLKLEGKPLLTESDIKDKLDKIDELEKEYQKELKTGKPIVTKNATVEKLKQQIETLENRILNVSIQLKDKEDNSEVSLGTSKMNYIDPRLIVMFSKKFDVPIEKLFTKTLREKFIWAIESADENWRF
(1678) DNA topoisomerase 1 [Candida albicans]
3
MNSSDEEDIALSRLAKKSSSITSASTYEDDEDDDIPLAKKSRKKRVESDYEEDEDEVPLKKLSNGRAKKQVKTETKVKKEPKSANKSKSTSKKDTKVKKEKTTVKKESKATSTKVKEESKTQSDSQASVKSETPEEDQGYKWWEVNQEEEGDGYIKWQTLEHNGVMFPPPYEPLPSHVKLYYNNKPVNLPPEAEEVAGFYGAMLETDHAKNPVFQKNFFNDFLEVLKECGGCGVEIKKFEKLDFSKMYAHFEKLREEKKAMSREEKKRIKEEKEKEEEPYRTCYLNGRKELVGNFRIEPPGLFRGRGAHPKTGKLKRRVVSEQVTLNLGKDAKIPEPPAGHQWGEIRHDNEVTWLAMWKENISDSLKYVRFANNSSVKGQSDFKKFETARKLRDHVDSIRKDYTKMLKSEKMQDRQMATAMYLIDVFALRAGGEKGEDEADTVGCCSLRYEHVTLKPPNKVIFDLLGKDSIRFYQEVEVDKQVFKNLRIFKKSPKQPGDDLFDRINPSLVNRQLQNYMKGLTAKVFRTYNASKTMQDQIDIIENEGTVAEKVAKFNAANRTVAILCNHQRTVSKTHGDSVQRINDKLKKFMWQKIRLKKMILQLEPKLKKKDSKYFEEIDDLIKEDIEHIHHTIIKRQREQAKKKLERDNEKLKLEGKPLLTESDIKDKLDKIDELEKEYQKELKTGKPIVTKNATVEKLKQQIETLENRILNVSIQLKDKEDNSEVSLGTSKMNYIDPRLIVMFSKKFDVPIEKLFTKTLREKFIWAIESADENWRF
(1679) DNA topoisomerase 1 [Methanobrevibacter smithii ATCC 35061]
3
MNEVIICEKPKSAEKIAKALSSKAKKNVFNKKVKYWTLERDGKDITVLSAVGHLYSLTPDNPKDKVYFDLHWAPLFEIDKKYKNYTKDYVRAIKKYAKDADSYIHACDYDIEGTLIGYHALKYGCGDDALKKSSRMKFSTLTKKDIVEAYENRIPIDRHQVDSGVARHILDFYFGVNISKALMKSVSAAKKRFLKLSAGRVQTPTLSILVDREKEIKKFVPKPYWLIKALLDGEIEADHVDGKIFDKTRAEEIFSNCENSDAAVDKIKYSNSTTKPPVPFNLGGLQSEAYNVFGFSPKKTQTIAQSLYTAGYTSYPRTSSQKLPESLDFKSIFLQLSKNSEFRTHISALPAKLKPNEGKKEDAAHPAIHPTGILPDKLDKDELKIYELIVYRFISVFFEAATFETMSTTLDIGGEKFKFRRRRVTHKGWLEHYPFKKIDNEEFPDVKEGDSIIVKEIVSEEKETKPPARYNQASLIKELEKRELGTKATRADIIDKLYDRKYITGNKIEVNQLGENIIDTLSEYCSNLTSEELTRDFENKLEGIDNDKATRESVVAEGEKEVKVILGDIDKNKVKIGSQIYDAYQESNIVGKCKCGGNLVKKYSPKNKSTFVGCSNYPDCKATYSVPKGANFLKKTCKTCGLPIISFGKPRQHACLDPNCGKENTKPREMKVVGVCPSCGKELIKRSGRYGEFVGCRGFPKCRFTCSLDELKDKVQ
(1702) DNA topoisomerase III, putative [Leishmania donovani BPK282A1]
3
MGRNVLMVAEKPSLAESIATILSNGSCSRRTRALPVYEYTGNFMGSPAYFKVTSTTGHVFSCDFTSQHQNWDRTDEEQLFTAPITWKDTSGKVSRHLEHEAQGCDTLVLWLDCDREGENICFEVMQVVRREIYNHHSIFRAHFSAITAEEIFHAFRNLGKPNKNISDAVTCRQELDLKVGVAFTRFQTKYFQGKYGDLDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRLVPVASRGGALLQFEWDRGRLFDETMARLILQRITKSGKVATVVNVSVSNDTRPRPTGLNTVDLMKIASRALGIGPHYVMSIAENLYIRGYISYPRTESTAYPPSFNLAGALAQQKNHSMWGAYVTALLQQGHARPKAGKDAGDHPPITPMRSASPSELSGDEWRIFEYITRHFIASVSPDCRLIKTKITIELGGELFSISGKVVEDPGFTEIMPHARVEDDRMPTGVHKGDSFQLSDVRLQAGQTQPPSYLTESDLIGLMEKNGIGTDASISTHVNNIVERGYCSVQAGRVMKPSKLGIVLIHGIKAIDPELVLPLVRSRVEEYVTHIAEGRAQLDDVLSYSLDLFFAKFKFFKEHIDVFDALMGASFSAISAAGKPITRCGNCMRYLKHLDTRPQRLYCPYCEVTFALPQGGTIKPYSSFKCPIDNFELVICHIEGGKSFPICPHCYNNPPFEDMRPAIQHHHRGYGGGAAATTAPSTRHMACDECRHPTCEHSLATNYVCDCVDGSCAGSMAFVPRTAGQWKVCCNKCPMMIKLPPTAQRVYVTSEECPECAANCLDIMFPEGKSVLPNRKDRIVACIFCHPGLSPLCEEVRGRIGNFRRIGGAAAGGRGGRGRGRGRGRGRGRGNREDRR
(1704) DNA topoisomerase [Acidianus hospitalis W1]
3
MFNLTGPSGFPVFEVEWKPLWEIDKKSYYTRKYLILLQRLCKYAKEYINACDYDIEGSVIGYMIIKNFGDLKKAKRMKFSSLTKEELIKSFNNLQPLDYNMVNAGIARHIVDWLWGINVSRALMNAVKDTSKKSVILSAGRVQSPTLIEVVKRHLDRETFVPLPYFKIELKIRLGNIINTVYLDQEFHNIDDVESLITRLKKDKLIVDKNILNKDKIIRPPPFNLGDLQLEAGRLFGLSPYRTERVGEELYLDGVISYPRTNSQKIPPTININEIVTGLSQRFGKLVDELNLMTKGKFIVRQGNKDDPAHPAIYPTGVIPKKLGKQESEVYELIVRRFLASISRDAEVTRQRIILEFEKEKLKLQLDFQKITYEGWLKIYPYHRFENEELVNVNEGSEVEIISIKPKLLLAKPSTRFTRVSLLKWMEDVKIGTEATRGKIIETLFQRKYVVTKRSYIYPTKLGIIVSEVLEKYFNELTDVKMTADMEDKLDEIIYGKKNKDEVINEVKDKISKYFEKYNEEKKIIGLELAKGLNLVAYNKCKLCDFEAMKDGLCKYHLIAKEKLDEAIKIWEDRTGYDIKMILKYIKGSKSTGKLISDLLSI
(1708) DNA topoisomerase [Ignicoccus hospitalis KIN4/I]
3
MKGHILVIAEKPKAAEKIANALGKPIVKRKYGVPYWELTNGKKIVVVPAAGHLFGLAPLGKGFPVFDYEWRPLYEIEKGASHTKKYIALISSLSPGSSLYVNACDYDVEGSVIGYIIIERFGDPRRSKRMVFHALTPDEIRRAWNSLRPLDWEMINAGLARHELDWIWGINVSRALMHAYRVATGKSKSLSAGRVQSPTLKEVVERELAVQCFVPEPYFSVSLSAKGVSLEPTLKFETKDEADHFISNCLGKVVDVIVNDERLSPPHPFNLPDLQMEAARLYGFSPSKTQSIAEELYLDAYISYPRTNSQKYPKDLDYANILKGIASVPQYRPLTKALFKETRGRFSPNNGPKDDPAHPAIYPTGKPPKNLSPDHMKVYDLIVRRFMATLASESVYEVTKVVIEVNGQTFKAVGRRVKWKGWTLYYPFSAPQEKSLPSFTKGESLQVKCTRRLQYTKPPERYTKAKIVKWMERVGIGTEATRARIVETLFKRGYLKNVGSKVYATDLGIGVALVLSKFFPEIVSVELTRRFEEDMKKIMMGVERKEKIVEEAKKFMRMILAKYKPHMREVGEYLAYSLGEMEPPGRCAVCWRVAEEDGLCVVHKRARDELYAKYPVWRRRLGLSFEEYLKKVTTLKQAGTAAKEVAKALLSEPTFKG
(1722) DNA topoisomerase [Leishmania braziliensis]
3
MPTWLNVAEKPSVAKEMAQSLSGGHCRTVQSQSRFNPVFEFNFEGKTMLVTSVVGHLMEDQFPPNTKNWSTYPFQGLFSAPISKYVRTDLEPVKKNLEALATRADALILWLDCDREGENICFEVMQVVQSKRPQVQVKRAHFSALTARDLLNAVHNLKLPDKRLSDAVEARQEMDLRIGATFTRYQTVKFRHLFAEVPGVLSFGPCQFPTLGFVVRRYWKQQGFVPEDFFTLQVQHGDTKFYSSRGSLYDQVAATLIYEDMLQAAAAEGHKGRITNVQQRPSRRRPPVPLATVIMQKLAATHLRISSERCMTLAESLYQEGLISYPRTETDSYTFQESELLELIRLQIANPDVAEYATAMLADIAARVRPPLRGGHDDKAHPPIHPTKAWNATRDERGSLYNLIVRHFLASLSPDAVAATTRVSAEFGGESFSTGGTTIVQRGWLDIFPYERWDSTCIPNYQIGDTFEPTAVLLKKGRTSAPPHLTESRLISLMDSNGIGTDATIAQHIKTVLDREYVRREGQSLVPTTLGIALASAYESLGLASLLQPQLRAQMELAMGDIANGAATKAQVVAAAVQLYEEIFSRLMASTGAFYEELKRHLRLAAETDTHAVQVTVVKDNFIQCGTCGRHMDLVERAGERDHDREVWSVRCRGCNKMHRLPNGRLNTLEPVNPPHTCPLCGFVVLRVTNREKQTSYHVCPHCFGSPPRAWNVTGCGTAGADALLPDIEAAAEFRCFQCTADCPLAKGLEAIGITTCIACHQHELRLRPGPNGFFLSCRGYPSCHLSVSLPAAASVKPSPSQRCPACNAVLLTFDFSGRQGVPGLNMLDTICIRCDARIKDYITVKGFLTGGASSSAMPSSAASVASTVTGTYTLPSVTSSARRSGRGGGQRGGRSGGAAAGEANMSTGRVDTVCGCGMPVKQLVSRKEASRGKRFLTCASRKCAFFQWLD
(1724) DNA topoisomerase 1 [Haloferax volcanii DS2]
3
MSRGPELIITEKDNAARRIADILSGETASAERMNGVNVYKWGGKRCIGLSGHVVGVDFPPEYNDWRDVEPVELIGAPVEKHPTQENIVAALRRLARRAGKVTIATDYDREGELIGKEAYELVRDVNEDVPVDRVRFSSITNREVTEAFENPDDLDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGNDFISVGRVQGPTLKLIVDREREIDAFDPEDYWELFSKLTKDADGDAESFEAQYFYLDDDGTEAERIWDEDDAEEAYQTLLGVEAAEVSSVNRRTRTDTPPAPFNTTQFIRAAGSIGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPRELLGAFEGDRRFKEDAESLLEQEEIEPTEGDNETTDHPPIHPTGELPSASDLSDDEWDVYELVVRRFFATVAEDAVWEHLRVVAEVEGLSLKANGKRLLEAGYHDVYPYFNSSESFVPDVEEGESLVLSDTHLDAKQTQPPRRYGQSRLIETMEQMGIGTKATRHDVIQKLYDRGYIESDPPRPTRLARAVVEASEDFAKLIVSEEMTSQLESDMLAIARGEATLEDVTEESKEMLGEVFEGLMESREELGKQLQDSLKADKTVGTCPDCGGDLVVRKSRRGSYFIGCDSYPDCTYTLPLPSTGKPLIMEESCEDHDLHHIKMLAGRKTFVHGCPLCKAEEADEEDDLVIGTCPECGEEHDGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGDIEVTDESCEEHDLPELRITYEGDREPWELGCPICNYREYQAQQNGEGGSELESINGIGAKTAEKLKDAGIEDVKTLKASEPDDIAAKVEGVGADTVRKWQTAAD
(1725) DNA topoisomerase 1 [Haloferax volcanii DS2]
3
MSRGPELIITEKDNAARRIADILSGETASAERMNGVNVYKWGGKRCIGLSGHVVGVDFPPEYNDWRDVEPVELIGAPVEKHPTQENIVAALRRLARRAGKVTIATDYDREGELIGKEAYELVRDVNEDVPVDRVRFSSITNREVTEAFENPDDLDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGNDFISVGRVQGPTLKLIVDREREIDAFDPEDYWELFSKLTKDADGDAESFEAQYFYLDDDGTEAERIWDEDDAEEAYQTLLGVEAAEVSSVNRRTRTDTPPAPFNTTQFIRAAGSIGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPRELLGAFEGDRRFKEDAESLLEQEEIEPTEGDNETTDHPPIHPTGELPSASDLSDDEWDVYELVVRRFFATVAEDAVWEHLRVVAEVEGLSLKANGKRLLEAGYHDVYPYFNSSESFVPDVEEGESLVLSDTHLDAKQTQPPRRYGQSRLIETMEQMGIGTKATRHDVIQKLYDRGYIESDPPRPTRLARAVVEASEDFAKLIVSEEMTSQLESDMLAIARGEATLEDVTEESKEMLGEVFEGLMESREELGKQLQDSLKADKTVGTCPDCGGDLVVRKSRRGSYFIGCDSYPDCTYTLPLPSTGKPLIMEESCEDHDLHHIKMLAGRKTFVHGCPLCKAEEADEEDDLVIGTCPECGEEHDGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGDIEVTDESCEEHDLPELRITYEGDREPWELGCPICNYREYQAQQNGEGGSELESINGIGAKTAEKLKDAGIEDVKTLKASEPDDIAAKVEGVGADTVRKWQTAAD
(1726) DNA topoisomerase [Gallionella capsiferriformans ES-2]
3
MKQAVKVTTNHSARNTFYLCEKPSQARTLAKVLGAEKGRDQMHFAEGVVIGHAYGHMLNLAKPETYIGTGPWCLDNLPILPKTWLWQVKDEHREHFDNLGKYLSQADLVVLATDPDEEGEVIGRQILQAHNYSGEVLRLWMSALETESLKKSLQNLRPLSETDHFYQAGRVRHEMDWLFGMNLSRAFSVLLKSKANIGRVKTRLLNEIVTNDQQAENVIQDGYETAYVMLGDTLLELIQADQPCDHIVNFKKLAGAQCGIYRNDKSCNYTDEMGVPLVTPRPLPYTLTALLADSADIGIPLDEGYKAVQKLYESGAISYPRTNSTKLPGTSSDDFAVHHAIVTMRDDLPTGMTEEATRIFELIRLNELYQRNQLITIDRTQTIEIGGEYFSSREEWKTISFDSPDRALLKNQNILANQKKLAIYKTGDEFPVTVRLTRENYGKPTYFTESSLLRMMAEKGIGTESTRVAAITNLIKEKLIDVTPQTDHEGLPSTQARTLRSTKLGRDLIRKLPEVVTGQEMEAQLQQALKEMRGGQSDESTHLMRTDAWLTQTIREAV
(1731) DNA topoisomerase 1A [Leishmania braziliensis]
3
MLRRSVRAFEKLVIVESPNKVIKVEGLLSDPKVIPDWSFSNSKLRTISTGPEKAIAMATTGHFMSLKELTWSPQLSRPAPGVTATDFPAKGLLVSFSLEWELIPGRRIQDTVSHYIEEKADNLTEIIVATDPDREGELIAVHAQNLIRRMFPKLSVPFTRAYMHSITADGIRRAMAERHEAFDYNLANAAEARHAMDRIFGFLGSSVVRYANPQMRSIGRVQTPALILISDREDKIKSYLDSHASTFEIQAMCHFTSKHDQRFSQVVTVTPAHKGGAAPVVWRDKVTVMHRCEQWALSSATQFSVSRTAKPQETVTPPPKPFTMATLIAKANRQLHYTSDMVSSCLQDLFQMGYITYPRTDSTRIDESILPSIYAAVRREHGKRLLQEQDGAARPSSRRSAAQKETANTNVEDAHEAIRPTNIDTTVEELGAVSAPMRHIYDLVRRNTMAVYMIPMRTERIVVPVTCRATNGEEVEFELQGKHVVEAGWSAAFRGDKGAVAPMAETDQDVQALEDGGIIVPNISDDEFKAIMDVADQRGGAGVKKGNLRLEAAQVSENRPSPPLPFSEGGLIEQLKNNGVGRPSTYPMIVKTLLARNYIMVNKGRCETTPVGRMLVETSRSTFPSIVDIGFTSAFEKKLDRIAKPGCVKELALPPNVSDADYVLSSFISSFLNYVTEATKAQRVAITTRSWTLQQEKSGVSSTPTDFQANLDKEKNRVMAQVPDLVDNMKNYRTFTALQNSLNDYLRRNFPPSATAVTSVSPSGIARSYGSSSTKKRSYGVTCKAAKKTPRRSHAKLKK
(1737) DNA topoisomerase 1 [Methanosarcina mazei Go1]
3
MHLIVTEKNIAARRIAAILAPKSPKKERVSGVDVYRYEIGSGENRQETAVVGLSGHIVGIDFPKEYNNWQKVDARDLIDAEITTTPINRKIVTALKSLGKEADRVTIATDYDREGELIGVEALNIIKKVNPKIPFDRVRYSAITPKAIEAAFSNPTNVDFNLADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLSVGRVQSPTLSLIVDREKERNIFVPTPYWEIHVELEDAAGETFSAQHSTRRFLDKEEASKVFRKLGKKAELKEIEKGTKTDQPPTPFNTTGFISAANSIGLSPANAMRIAESLYTNGYISYPRTDNTVYPDTLDLKAQIEIFKEGPFKEYANTLLEKPELVPTRGKKETTDHPPIFPASLAKESDLKEDEWKVYELVVRRFFATFAGPSIWETMRLKLDIEGEEFRANGARLLEPGWRWYYPYNAPEDRLLPELKESDLLKVIKKEMLDKETQPPGRYGQGRLINIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVMDTLEKYSPTITKPDMTKLLEENMDKIAEGKIKEEAVLEESREMLKQVFSELDKNRDNIIESLQAGLREDKIIGDCSLCGNELMIRRSKRGSRFIGCSNYPNCTFSLPLPKSGQIIVTDKLCEAHGLHHIRIINQGKRAWDLGCPQCNFIEWQKTQKEEQAQQPKKEKPKSIKDLEGVGKATAGKLEEAGITSVEALAEADPVELAKTIKTSVKKIKNWQTSCNGGAVEDL
(1741) DNA topoisomerase 1 [Halobacterium salinarum R1]
3
MELIVTEKNNAARRIADILSEGGASTTQTAGVNVYEWGGRRCIGLSGHVVGVDFPPEYNDWRDVEPAELIHADVVKDPTQEDIVNALQRLAREADDVVIATDYDREGELIGKEAYELVREVNEQAPVNRVRFSSITDTEVRSAFADPDDIDFDLAAAGEARQIVDLMWGASLTRFLSLSAGQMGEDFISVGRVQSPTLKLIVDKEREIEAFDPDDYWELFADLRKDQTTFEAQYFYEDPADGTEAERVWNEGDADAAFDALRQAGEAVVDSVSRRTRTDDPPAPFNTTQFIRAAGSLGYSAGRAMSIAEDLYTAGYITYPRTDNTVYPDDLDERDLLEAFQQTVFGDDADSLLDQDRLSPTSGDEETTDHPPIHPTTDFPDRNQLSEDEWAVYELVVRRFFATVAAPAEWAHLRVTADADGESLKANGKRLVEAGYHAVYPYYDSSENHVPPVEEGDTLAITDARLDAKQTQPPRRYGQSRLIETMESMDIGTKSTRHNTIEKLYDRGYIENDPPRPTTLAEAVVEAAEDYADVVVSEEMTSQLEADMTAIADGETTLDDVTTESREMLDRVFDELTASRAEIGDHLRTSLKADKSLGPCPECGDTLLLRQSRTGSHFVGCDGYPECQFTLPLPSTGDPLVMDAVCEDHDLHDVKMLAGRNTFVHGCPLCAAEAADESEDRLIGPCPDCGEPHGGELAIKQLQSGSRLVGCDRYPDCEYSLPLPRRGDIEVTETYCDEHALPELVVHDGEDDDPWELGCPICNYEEYQARQRQQGLEALDGVGPKTAAKLESAGVEDVGALADADPEGIADAVSGVSADTIREWQAQAD
(1761) DNA topoisomerase [Clostridium tetani E88]
3
MNLAKVIIAEKPSVAKNIADALNIKTRKDGYFEGKEYLITWAFGHLLQLYDAKDYNEIMKGWRLEKFPFIPMNFKYKIKQQNNNKNITDEGAEKQINIIKSLIERENVEAIISATDLDREGQIIGDELFSYLQIKKPIYRLLLNEWTPDEVKNGMKNLKCNEDMKFLRDAGISRQWSDWIIGINLTSVATLKYNIEDNKILNIGRVILPTLKIIYDRDKEIENFKATTYYKLLANFKTKKDKEFEGTYYEKNSEKFQDKSYLKIIEDLLKNKTYNIVDKHVEKKKEYAPYLFNLSNLQGYVTSKYKGWTSDKVLKVAQSLYEKKFITYPRTSSSVLDESLEGRAKKVLETLKKGLSYENQIRFNKSKRIFDSSKVESHSAITPTYIKPSKLTRDEEIVYIAIKNRFIMQFMPIAEFEETKITIKANDEDVKGEFLSKGKVQIVEGWRIVEKIETKDTILPLVEVKEKVDAVNSKIKTVTKKPPKHHTEKTLLRVMETCGKSFKDDENSEEMMNAILSGFSIGTAATRADTIKKLKDIGYIEAKGKSLICAPLGRTMIEIFPVKELLDLEYTGKLEKTLSDIEKGKFGKKEFMDLIYEFTNRAVELIKSDNSMLNKIKINLPEGVENLGKCPQCGNPVIEGSKGYGCSNWKNGCKFTIWKNDKYIQSFGKKVTKDMVKILLEKGRVGFRNLKSKKGNVFTAYFTYENNKEKGYYSWKMHFIN
(1762) DNA topoisomerase [Ignisphaera aggregans DSM 17230]
3
MNIKDYILVIAEKPKSAEKIAYALGNPKKYRINGVPVWFVMRGTSRFVIAPAAGHLYTLHTESKGFPVFDYKWVPKYIVEPESIFTRKYLNVLSMLAKNAKEYINACDYDIEGSLIGYMIIKNIGDIKRSKRAKFSSLTASEIVRAFNNLLPLDYNMIEAGYCRHILDWLWGINVSRMLMSIYRSVFNEKRILSAGRVQSPTLSYVVNIDLQRKTHVPVPYAYPSIKIFIDNKIFKLIPIDSPFNSLSDAKEYLENIKRDPRATVLDIIVRDERIEPPHPFNLPDLQSEAHRIYGFTPYKTQKLAEDLYLEALISYPRTNSQKLPPTLNNREILEKLSQNIVYRTLVKTLLAETRGILRPNNGPKEDPAHPAIYPTGEGTLKGLSKDHIKLYDLIVRRYLATFANPAVVQYVRIEFIVHGRRYYLSTNIVRSRGWLQYYPYIHFNGEEISLKLLRKGLQIPIHEAKIVIHFTKPPHLPSKISLVKWMEEKGIGTEATRAEIVETLFKRGYLYMRGRGSGVSELGILISFLLKDYVEELISVELTRKFEERLNMILNMKAKCDDIVEEAKEMLLKYINRVKSLDIQTLRAEISKYIEMSDNNGRRCMICKRSVYANNLCIFHNIALENIRSAYETWRKFGFSWTQYLEKLLKLKSTGSYVKEVCRHLIKQGEF
(1769) DNA topoisomerase [Nanoarchaeum equitans Kin4-M]
3
MIIIAEKPSVAKRITFSLTTNYKLISKNPPQYYFKIDSKPVIVIPAAGHIYNLDTNQRGYPVFDYFWNVEKGKTKFAKAFSKYKNEKEVIVATDYDLEGELIGYNILRFALNKTNAKRMVFSALTPKDLREAFFNLRESIDKNLAIAGETRHIIDWLYGINLSRALTYALRHYVKDVTLSIGRVQGPTLRLVYEREKEISNFIPEEYYRVVFIHKNYKFYYIEKLKNLERAKEIAKCKELKIVRVKEEKVYLPPPHPYNLSAIQQDAYKFYKISPKDTLLILQKLYTNGYISYPRTSSNILPESLDYRYILEKLKLWGYSYYISYLLKKPILKPNNGNIEDAHPAIYPTGIIPKGLSKKESLIYDLIVRNFIATFMDKALIIKFKVYGRCDKYLFVYEGQSYGNSSGK
(1773) DNA topoisomerase 1 [Methanocaldococcus infernus ME]
3
MILIIAEKPSVAKKIANALGKAKKKKIYDVPYYEVDYNGKKIVVASAVGHLFTLVEKNKSFSYPTFEIKWAPAYIEKGKSYVKNYIRALKELSKYADEIYIATDYDIEGELIGYHALKFCCGRDKGKRMKFSSLTKREIIKAFENPISMDYGLVDAGESRHIVDWYFGINLSRALMHAVKALNDWKILSIGRVQGPTLYFLAEREKEIKEFKPKPYWILEAYLKNLKAIHEKEKFWDEEEAKKIYEKVKDAKYGEVVKVERRVSKIKPPVPFDLGTLQREAYNYFKFSPKKTQEIAQSLYEKGLCLHPDTLILLPDGVKKIKELKEEGEVLCLNHNLKLTKSRYKLLKRTVREKLIKITLNDGTELITTREHPILVYRDKLLFVPSERLKEKEQIITLGHQNKELSLDNYLINEDLKRISEGDVYISKIKKIEEIEYEGEVYDLVVDKFHNFIANGIVVHNCSYPRTSSQKLPKDWSYLENILKTLKNSEYWKFAERIIEEKRKPIEGKKDDPAHPAIHVVDYPKNKEELSKEELKVYDLIARRTLSAFWDEVEREHINAKISINDELFKASGSKTVKEGWHVIYHFPTFEELNLNLKEGEKVKVEKIKLVKKETKPPKRYTLSSIIKELEKRNLGTKATRAEIVDKLIKRGYIKVSKNGSLEVTDLGASIVEVFKRFCPEIVDEKLTRELEDKLENIQMKKINKDLVLEEAKKRLIEVLKKFKEKEVEIGKNLTNKEVVGTCPRCGSPLVVKEGKYGKFIGCTNFPKCKFTKSLE
(1782) DNA topoisomerase 1 [Methanothermobacter marburgensis str. Marburg]
3
MHEVIICEKPKSSEKIAGALFPDAERKKYRKVSYWEYSEGNKRVTIVSAVGHLYSLRPSKPGEEHFFDLEWAPLHEIDKKKNYVKDYLNVIKKFAAGADRYIHACDYDIEGTLIGFNAIRYGCGEDALQKTVRMKFSTLTREEIQSAYEKPIELDCGQVDSGAARHILDFIFGVNISRSLMKSVKEATNRFIKLSAGRVQTPTLAILVEREKEIREFEPVPYWIIQAELESGIVAESRRGKIFQRPLVDEVLERCSGSDASVRGVKVRDTVRKPPVPFDLGSLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYRKILDRLSEDPRFGAHIEGLSEPLKPHEGKKVDDAHPAIHPTGLLPSDLSSDERKIYELIVHRFISVFGEDAVLQTMRVDLEIGGEEFSFSRKRVSKRGWMDSYPYTRIEDEVFPDISEGDVMGVVGVSTLEKETKPPARYNEASLIRELEKRGLGTKSTRADIIAKLYDRKYIEGKKIRVSPLGENIIDTLTKYCEKITSEELTRQFERELEEIMEGKISRDRVVDEAIEEVKSILSDIERNMKDIGRDLYKAYQDSRVVGECPACGRNLVIKYSPRNKSTFVGCSGYPDCRTVYSLPRGASVLKSRCEKCGLPMISYGRPRQRACLDPSCGKKESKGEEIVGKCPECGSDLIKRSGRYGEFVGCKGFPRCRFTCSVDDVPAA
(1787) DNA topoisomerase [Methylobacterium nodulans ORS 2060]
3
MARASADRTLFFFEKPSAMRQLQRFFKAPTTICVSAEGHLLAAQEPAAIRPAWKAWRFDDLPIALDEIPVAYARNRSGASHAGRIEAIRGALQGVDRVIIATDPGREGSMIAWEVLEHLGYRGRVERLRLGALDEVSIRRAFAALAREPDSGERDYAAYLEALCRRYEDWHLGLNGTRAVSLRLRPPAFREPWRFGGVQTPTLAILADLERRIRDFVPRDFFKVAMPVETETGAALTLWHAPKERIFDRAEADAIREAAAGWSGPLSVVQKDVRRPPPRLFSKDTLARRCAKRFGWDPQRTAATAQDLYDSGFLSYPRTESEHLPESQSGDAAAILAAIAGCLDDVAELVPAGEAIVVRRGPRGHYVKDPGEHHAIVPLRKVPRRGELGPEAWRLWELVAKSYLAAHLPDGIDARTTVAAEVATPPGPKRFAVTGSVVRAPGWRAVYGSEAEDEDPVPGKARRDDEPTTGRLPPLRDGAAARATDATVETAVTEPPRRITRGELPVVMGRLIDQVEDPVLRRALENPANPNEPRGLGTAATRDAVLPKLEKSHYVVLAKGKDPAITVTEAGLAFIDAVRRVFPAYGDPVGRAVFEADLAEIGRAPSRAEAVRRAEEFRQRTRARLDALIAAVAGSERLAVAAPSPDGAGRPPTPAMVAFATALAARKGLRLPRGLKQDAAICRRFLDAHAEQREAAAPGAPRPPTPAMRRYAEALARENGLDKLPDDAATDFSACRRFLDAHAAPRPDAPAKPSPRKPAPRRRTRPPAGADRHADTSN
(1795) DNA topoisomerase [Clostridium lentocellum DSM 5427]
3
MKKVIIAEKPSVAKNIADAFDIKTKRDGYYEGEDYLITWAFGHLLQLYDAKDYDESMKSWRLEKFPFIPEEFKYKVKSDGKNKAIEDVGARKQLNIIKDLIDREDVESVISATDFDREGQVIGDEIFLYFNEKKPIYRILLNEWTPEEVKKGISQLRPNEEMKSLQDAGIGRQWADWMIGINLTSVATVKYNSGSKKILNIGRVLLPTLKIIYDRDKEIEQFEASTYYKLLANFKTSQDEVFEGTYYEKDEEGKDNEKFDNKATLESMVELIKNKPAQIVEKQVEKKKEYAPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKYITYPRTGSLALEESLKGRTKKVLDTLKIGLPYEGQICFADHKRIFDNSKVESHSAIVPTYIIPKSLTPDEQVVYNAVKNRFLMQFLPIAEFEETKLITKIIDVPEESLKGVFISKGKVQLVEGWRIVEKFEAKGTKEGKENKDTLLPQVTQDELVEMKNANVAEVTRKPPKAHTEKTLLRVMETCGKSFKGDEKEEGKEESEEDTLKMMASILSGFSIGTPATRAETIKKLKDAEYIRAKGKSLVCTDLGKALVETFPAKQLLDLEYTGRLEKTLSDIEKGKFQKDEFLSMIKAFTEEAVEAIKNDTRVLSGTKVEVPKNMEPVGVCPVCGNAVVENEKAFGCVNWKSGCKYTIWKNDKYITMLGKNVTRQMVELLLKNGKVGFRNLKGRNGNTYAAYLKYVKNDQTGYFNWEQEFI
(1797) DNA topoisomerase type IA central domain protein [Eggerthella lenta DSM 2243]
3
MKLVVTEKNDAAQKIADLLGVKKPKADKVYSTPVYRFDVDGEEWVTIGLRGHILEPDFAPTMVYKKRGGWQGVTEEGETLPAELPASLPKPPFKKKKPFTEDGVELKSWKMDALPYLVYAPINKLPKEKEIIRSLKNLAKKADSVIIATDFDREGELIGSDALSCIQEVNPTAPVSRARYSAFTKEEITHAFDNLVELDVNLASAGASRQDIDLIWGAVLTRYLTLVKFAGYGNVRSSGRVQTPTLALVVARERERLAFVPEDYWVIRGAFGADPDSFEAPHATARFKAEAEAQAVMAHVEGATRATVASVEKKKRTVQPPAPFNTTSLMAAASAEGLSPARTMRIAESLYMDGYISYPRVDNTVYPSSLDLADTVKAISGNPAYAPYCKELLAKGKLTATRGKKETTDHPPIYPTAKATPDDLAPADYKLYNLIARRFLATLSEAAVIEGTKVTLDVNAEPFVAKGDVLVKPGYRAIYPYGLKKDEQLPALSEGETVAFNGAVCTKKQTEPPARYSQGKLIQEMEKLGLGTKSTRHAIIERLYAVKYCMNDPIEPSQLGMAVCDALDKFAPHITHPEMTAELEEEMDNIAEGRTTKAQVVDTSRNLLSEQLASLLPHSEEVKEALADAVAADAYVGPCPKCGKDLQLRASQKTRSMFIGCAGWPDCDVTYPLPKGKVEAVPEPCPTCGMPQVKVTAFRSKPRTICIDPHCSTNQEPDVVVGECPACKEKGIQAKLIAQKNPRTLKRFIRCENYDDCGTGYPLPQYGALTATEEVCEHCGAPMVIVTTARGPWKLCPNFDCPGKEQKEDEKGAKGAKGTAAKKPAAKAPAKKPAAKKAPAKRAPAAKKD
(1799) DNA topoisomerase 1 [Thermococcus gammatolerans EJ3]
3
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVSYYEFTRDGKKVIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKNYAKDYIKALATLAKRADEFIVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNLEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVEREKEIQNFKPKPYWVIKMILEKNNSQYTATYEKDKIWDEEEAKRIVSEAKKGPAFVEKVEVKQQKRNPPVPFDLGTLQREAYSAFGYSPKKTLELAQRLYERGLSSYPRTSSQKLPKNLNFRSILQNIAKLPEYKPFAHELLGKGTFKPVEGKKEDPAHPAIYPTGELPKPGELTKDEQNLYDLIVRRFLALFMEPAVRESMRVIINSNGHRFILSGARTLKEGWLKVYGKYVKFDEVILPQFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIKVTPLGMRVVEALEKNVPDIVSVELTRAFEEKMEEIMAGKAKRDEVIEESKEQLIKILKVFKEKELDIGKMLLETTSKDSVKVEKSSEISGTSSRSGASKGENAKSSESSRKRLVLGKCPKCGGDLVLKYNRKTGKRFVGCSNWPKCNVTYPILQRGEVIPTGKTCCNGAPVVKIREKGREYEICLDMNCKEWKK
(1823) DNA topoisomerase [Macaca mulatta]
3
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAYGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEIMPWQSVPLEESLPTCQRGDTFPVGEVKMLEKQTSPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVSVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCSVVAHCFENAHRVRVSTDTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARRPPGKPNPRRPKDKMSALAAYFV
(1833) DNA topoisomerase 1A [Leishmania mexicana MHOM/GT/2001/U1103]
3
MLRRGVRALEKLVIVESPNKVIKVEGLLSDPKVIPDWSFSNSKLRAISTGAEKAIAMATTGHFMSLKELTWSPQPSSPASGVTAADFPANGLVVSFSLEWELIPGRRIQDTVSHYIEEKADNLTEIIVATDPDREGELIAVHAQNLIRRMFPQLNVPFTRAYMHSITAEGIRRAMEERREAFDYNLANAAEARHAMDRIFGFLGSSVVRYANPQMRSIGRVQTPALILINDREDKIKSYLDSHASTFEIQAVCYFTSKHNRRFSQMVKVTPGRKGGAAPVNWSDKATVEQRCEQWALSSATHFSVSPGAKPQETVTPPPKPFTMATLIARANRQLHYSSDMVSSCLQDLFQMGYITYPRTDSTRIDESILPSIYAAVRREHGKRLLQEQDGPSKPGSRRSTAQKEAADANVEDAHEAIRPTSIDTTVEELGAVSTPMKHIYDLVRRNTMAVHMIPMKTERIVVLVMCRAANGEEVEFELQGKHVVEPGWSAAFRGSKGTVTPVTETDQDVEAVEDGGVVVPSISDDEFKAIMDVAAHRGGGTGVKKGSMQLESAQVAENRPSPPLPFSEGGLIEQLKNNGVGRPSTYPMIVKTLLARNYITVNKGRCETTPVGRMLVDTSRATFPSIVDIGFTSAFEKKLDRIAKPGSAKEWALPPNVSDADYVLSSFISNFLNYVTEATKAHRVAIATRSLTLQQEKRAASAMPMSPTDFQANLEKEAKRVVTQVPDLVDNMKSYRTFTALQNSLNDYLRRNFPPSAAAMMPASSSGTARSYGRSSSSSTKKKGSYGATYKADKKTPRRFRTKLKKPKK
(1842) Topoisomerase (DNA) III alpha [Thermoproteus tenax Kra 1]
3
MLIVAEKRSVAQAIAKYLATSYSYFKISGVMAYRFKYKDRQAVSLGLSGHILDFDFPQELNKWNALEPVELFDKITVLVPRDETIKYLYALRALARDEDEVYLALDADSEGEAIAYEVVLQVRAVNPRARFKRVRFNAVTKKDIVQAFERPVELDLKVVEKVFARMVSDLTIGAAFTRLLTLAVREVDNKALPFGKFLSYGPCQTPVLGLVVSRELERLNFKPEEYYVVKGIVETEAGSFEARSRPFKAREEAEAAVRAARVSLGKVIEARFEETRVKPPAPLDTVELERRASKWLNIRAKAALDTAEELYRRGYISYPRTETTIYPPTLDLRAVLEELTNTQFGQYAERLLRGPISPTRGNSDDRAHPPIYPTRGATKAEVERALGTRAWKLYEFVVRHFLATLSPPAIVERQRIAVAFGPLVLEAEGRRIIERGYWEIYPYEEEEDRRLPRVQAGVWARMVSAKIEKKKTEPPPRMSESELLRLMKKYGIGTDATMQDHIHTNVIRGYMRIVGGRCVPTKLGMTLASSLMNHARPIIDPTVRSKMEAALQDIAVGRADVKKVLETIRGEFKTFYKGLYEKRQEIARELVKVLREETRNGPRSDV
(1854) DNA topoisomerase 1 [Methanococcus maripaludis X1]
3
MTGLIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKTKTKFGDYPVYDINWVPASTLDEKKYIQKYIDALKKVSKDANKFYVATDWDIEGELIGYHALNFSCGQKNAHRLRFSSLTKKEILKAYENPNEIDFGLVDAGDSRHKIDWYFGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALLDNDLIAVHELEKFWDEEQANKAYEKVKGQKQATVSDVKKSMKTIPPNPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEKGYCSYPRTSSQKLPDDKAYMDEVLKNLSKNKNYKPYIETILNENRKPISGKKDDPAHPAVHAVDVPKEKLPDDELKLYELIARRTIALYWDNAKREYSKINLDINGETFKLSGSRTVEEGWHEIYYYTKFDEVELPELKKNDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYVIEDGSLTVTDLGIGVTETLRKYCPEIVEETLTRDLEDKLELIQDKKIKKEEVIQETKDKLTKILGEFRLKEKEIGTELVDKLDSTNRSLQIIGKCKCGGDMIIIRTKGKKRFVGCSNYPDCEVTFPLPQKGRIKVLNEVCEKCQNPVIGLDRIKICVNPDCSTRISEEDKKEIEKAEKEEKICPKCGNKLLIKKGPYGVFRGCENYPKCKYTEKLNGESNEKEIVGKCPKCGSDLYKRKGRFGEFIGCSNYPKCRHTEKIDKKKEDTPGETKAETKKEAKPKTTKKAAPKKTATKTTKTTAKKTATKKTTTKKATAKKTAEK
(1858) Topoisomerase IA [Leuconostoc sp. C2]
3
MPNYLILTEKPSAAANFVKALGGKTGTFNNFTYKITNLRGHVMTLKDPEEMVAEDLKKQYKSWLVKHLPWDLNDFSWERTYIRQRNMRTGKTESTKKIIDELKKEAKTGYDAIVIATDTDPSGEGELLAWEALDAIKWRGQVLRANFMDESATGVKTAMMNLRDVSDKQQDGEYIKGESRNRWDFASMQLTRIATTAAKKQGFKVVAREGRLKSVIVWQIYAQLLAIKNYVKKPYFEVKFKDPAGHIFGRVTPDGDVIPWRFSTKNDAQKDMTQYHESAVANEKHQTRTQAPGKLLDLAGLAAILAPRGFSAKEVLSTYQKMYEAQVVSYPRTEDKTVTPEQFNELLPKIDQIAQLVQVDTRLLTHRQPRPTHVKKQGAHGANRPGENIPTSLTSLTKFGPSAQAIYDILAKNYLAMLAEDYVYDHVTADLQDYPRFKTAFNIPIEMNFKAVYDSQRAVKVEDEVEDDNSGQLGPNAQPYLYEGANKKPQTPTTKWIMAFLEKHHVGTGATRVSTLSDMSRGTKSMIKETRGKLMLTETGNVSAVMVKDTWIASPKITKRLFEMMDQVGQFEITMPKLLDSITQVVEHDMPIMLSNADELELLLGKPKPALKRPVTEKITGVFKGEEITFAKSWSGHSFTDDELTKLLNGDEISFDAKSKRGKSYTAIGKMAKQTFKGRTFYGFKLNPK
(1862) DNA topoisomerase 1 [Methanocaldococcus vulcanius M7]
3
MTALIICEKPSVAKKIANALGKPKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVENENNEFGKYPIFDIKWVPASVDKGKEYVNKYIKALKKLSKEADEFYIATDWDIEGELIGYHALKYCCGREKAKRMRFSSLTKKEIVKAFENPDEIDYGLVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFIPKPYWVIEALLKDNLKAIHEKEKFWDEKEAKSVYEKIKDEKSAKVVEIKKTKRRIKPLPPFDLGTLQREAYSYFKISPKETQEIAQRLYERALISYPRSSSQKLPKDRKYLEDILNIIKNHPIYGKWAEKILEKNLKPVEGKKDDPAHPAIHIVDIPKEELSEKEKKIYDLIARRTLSAFWDNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDEIELPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKRGLGTKCLTAKTLIKVKIDNEIKYMEIEKLFELLNEKYKEKNIELAVNNKDIKCFSFNYKDEVESSFKFISRRKLEKDESVYRIEFEDGSFIEATEEHPILIYDNGDFRYVKANDLKKGMKTISFTDNKDFITKTISNIRKINYNGYVYDIINSEYLNFIANNIVVHNSTRAEIIDKLIKRGYVVDDGSLKVTDLGISVIETLKRFCPEIVDEKMTRDLEEKLEKIQFRKIKKDEVLDEAENKLRKILEEFKEKEEDVGTYLIKNLDATNKKAKIVGKCPKCGGDLILIRHKKSRFVGCSNYPECDVNYSLPDKGRIKIPNKVCNACKSPILKIGDREICINPECPLKQVEIKEEDRICPKCGAELILKKGVYGAFYGCSNYPKCKYTEPINKKEKEIVGKCPKCGGDLVVREGKFGKFIGCSNYPKCKYTEKLKENEKKENKKGEDKT
(1873) DNA topoisomerase 1 [Candidatus Korarchaeum cryptofilum OPF8]
3
MTTLILTEKPNVAKRIASILSEGAKAKREGKVYYYEFDTGGERYYVAPAAGHLLELDYPPGKWEYPSIVPPERLVLKEIKGKREYLKILEKLGKLSNRIIVATDLDSEGSSIALEIIKALNWEGKEILRMEFSSLTKEEIRSSFRDLKPFDYPRAYAGWVRRVIDLEWGANVSRGLTLSTRRKGWVRVLSSGRVQGPTLSMIVKREREIREFVPKKYYTVIVKVDKGFSLELAPPKGEERIWDQDYARRAAESVKDTLIARVKSDERKLSPPPPFDGTSLQVEVSAITGLTPRQIADRTSGIAQKLYEAGLISYIGTESQKYPKSWKKKDFVDMVKLIASYSPLKEEAEFVLGDMREAAVEGKKDDPAHPTIHVVGVPEERLEGKYREVYEIIARRNLATLAQDALIKRIRVESNVDGFIFRASGLSVLREGWLRVYPYARMEEFPEVEDSEELRVVEVKIEEKETQPPKRYSHISLIKEMERLGLGTKNTRVQIIDILKSRGYLEEGSFKPTRLGEAIVEVLESFVPALTNPELTAKLERGMNEIELGKLDPSNFLKESLDELSAIMDEFKRNELKISERLYEGLREYRSGSLGKCPECGGDLNMRKSSYGYFIVCSNYPEKCDVKFNLFKNERFEGKFCECGLPLVSGRIKTKSNRGRGYTRCIANCDRTPLRCAKCGGPMVAKQGKFGVYLKCENCGSTNFFRVRKH
(1878) DNA topoisomerase 1 [Methanothermococcus okinawensis IH1]
3
MTDLIICEKPNVAKKIASALGNPKKKSNNGIPYYELERNGKKIIVASAVGHLFTLEEEKTGEKKKFGEYPVFNIKWVPASTIKGKEYVQKYINTLKKLAKEADEFYIASDWDIEGELIGYHALYYCCGKNDAKRMRFSSLTKNEIIKAYENPDRVDFGLVDAGDSRHRVDWYYGINVSRALMQSIRAVNRWQTMSTGRVQGPALSFLVDRELEIKKFVPKPYWVIGAHLKNELLAIHEKDKFWDEKEANEIYNRIKDEKEAIISSIKKTKKKIKPNPPFDLGTLQREAHRIFRFSPKKTQEIAQKLYEMGICSYPRTSSQKLPKDDNYIKDILTKVSNHGDYKKYAELILRENRKPIEGKKSDPAHPAIHVVDVPKELLNDDEKKLYDLIVRRTLAAFWDNAEREYINVVLNIDGENFKLSGSRTIKEGWHEIYYFTKFDEKELPSLRKNDKIPVEKITIERKETKPPKRYTMASIIKELESRELGTKATRADIVEKLVKRGYLIDDGSLKVTDLGIAVIETLKKYCPEIIDEKMTRELEKKLDRLQKRTIKKENVLKDAENKLRAILEEVKKKEKEIGKELVEKIDTTNKSLKTVGKCECGGDLIIIKTKGKKRFIGCTNYPECKKTYPLPQKGRIKILNETCEICGAPIISIDNQKVCINPECPSKISNEDKKEMEKAEKSEKICPKCGGKLVVKKGIYGAFLGCENYPKCRYTEKLNNKTKTEKAEKVVVGKCPECGGDLIMRKGRFGEFIGCSNYPKCRYTEKIKNEKTKTKKEKK
(1885) DNA topoisomerase 1 [Thermoplasma acidophilum DSM 1728]
3
MDGFRIIIAEKADAGRRIAYFLSGGQVKSHRAKGTSYLEFEYNGSKTYLIPLSGHIVEADFESGYSDWNKIDLSDLIDARIVKNIKNKVAYQTLQAFRGKVEEIVIATDYDREGELIGVEALDIIKEGKEEIRRAKFSALTKNEILDSFKNLIGVNYSLADAADARESIDLIWGSVLTRFFSVTTGRLGKSFLSAGRVQTPTLAIVVDREREIQSFRPERYWTISITFDKDGQFKARYPENIKDQDTAEKIYEAIKGKNGRVSSYTSKEDHIRRPAPFSTTEFLREASRIGIMPTKAMSIAENLYMRGLISYPRTDNTVYPRSINLKSVLKKLENTAYSKYVKEIETFDRILPSRGRIETTDHPPIYPVDSPKEQLKGDYGRVYDLILRHFLSTLYRDGKKTVAEAEIYVNGYTFKAAGQHTTDRGWTEIYGYDPKDVYLPELTEGEDLKAIDWNIQREETKPPPRYDMSSLLKKMEELNLGTKSTRHDIIGKLIERGFIEGNPVKPTPLGMAFIDAVRSVNSHIADPEMTAKLEEDMDRIEKNEMSKNDVVEESKKMLHEVLSHFLTKTADVKDIITKGINAGQEIGDCPFHEGKKIMVIRDRFTYTVRCEDPSCKINFRIKRNGSITLSDQKCPVCGLPMIKIIRKGQSPEIKCIDPDCSYNRENEDYGECPADHGRLVLRQSKYGKRFLGCSNYPKCTVTYPLPQMGRITKTGEVCPYCGAPILALSRNGRKWKFCPNMQCEYNKKRKPEAAVEKSVRKKGRNASKS
Taxa distribution
Family tree
3