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Family 6
Informations
Name
6
# topoisomerases
112
Sub-families
No subfamilies.
Topoisomerases
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Name
Family
Sequence
(4) Reverse gyrase [Caldivirga maquilingensis IC-167]
6
MRDNKGDGGSGEPLVLYHGMCPNCGGPVTSDRLRDGLPCHVCLPEGSRLRAASLRVVLSELNREGRLVRLRDIFNYLMKYDEFSELFRKATGTSMWGAQRFWAKRLIKGKSFAIIAPTGSGKTTFGLVASIYVASKGGRVLMVFPTSTLAYQVYKRALTYRDSAAVNIKVITYNGLLSEKDKSEVLNAIKAGDFNILIVTNAFLPKGMEILSKYRFDLVFVDDVDSVMKASSRNIERLLQLLGVPREAIDKALEIAKISDFKEREGKVSELRRILEGRRIGSLIVSGMLTRTRRTARAALFREILGFDVGGRAEGLRNVVDLYIKPKGDLKVIILDLIRRLGDGGIIYVPTDLGREFAEELSKFLNDNGINAGLYLKPKRKLIEGFEDGSIPVLIGLATSRSALVRGIDLPHRIRYVVFAGVPKIRFRLSLKEFNPGRYIMLLSSLRVIAPSEYKTRIDKTVSSLRNIMNLSQDRINKIIEAIERGESLQGFDKYASEVISNAIKLAQDLLNRDDVREAMSKSIVNIQRMGDDIYVILPDSPAYIQGSGRTSRMYLGGITHGLSVLIVDNEAVFNSLSRDLRYRLVDFQFINYEEFNVDALLKTINEERELIRQIMTGNVPQSISQVDPLKSVLVIVESPTKARTIANFFGKPSTRVLGSLIVYEVTSGNLLLNIIATKGHVVELATEQYAQSVSSDVDYVTKFISSVTRNYYSVLKIDGNFIPIYSTIKRCPTCGRSFTDDVSKCPFDGTPLVDSSGVIEMLRDLATEVDLVLVGTDPDSEGEKIAWDVFNMLRPFVQDIRRIEFHEVTKRAILNALANPRGVNGNMVKAQLVRRIEDRWIGFGLSSYLQRAFNDRNMSAGRVQTPVLKWIIERYIEYRRNRVIRLIVRKRISDGKVLEVSFDKVTNGDETARVRHDLRDVAKDKKGLRIIITKLSESEEEVNPPPPFTTDSMLTEATARLRAGTEEVMRLAQELFEMGLITYHRTDSTRVSAVGISVAKEYLTNRFGEGVFTAREWGMGEEGAHECIRPTRPIDSEELRSLIDSGVLKLKLTNRHIALYDLIFRRFMASQMQSGLVKKVKVEVKLMRNGDMLSSRVDEFVTSVIRNGFLAIYPTIRVTQFPESSMELPVTEEDEVIVKTVHTTYPYREGDIVAEMKRRRIGRPSTYAKIIETLKRRGYVKALGSTKVLIPTKRGVAAYICLSNDKDVAKLYLSTRRNKVQENTEFESLLKQCNVNFKCLISEDRTRMVEEHMDNIENGDEDYLTVLHELFNEAVKYGIMPQN
(7) Reverse gyrase 2 [Sulfolobus solfataricus P2]
6
MINVMYKNSCPNCGGDISGDRLLNGLPCEACLPYINGIDDVDHISKVKTLYNILLNNDKIKNYWNLYYNITTFETVFKYFRDKTGYEPWSLQKLWLRRLASNQSFTMSAPTGLGKTTTLMTYSVFIGQDVVYIVPTKSLMEQVCKRLEKLGAQVSCGKIDQKKVSVITISYLNKNADSIVSLKPNFVVIDDADAVIKSGKTTDRLVSLLGIPKDVYESAIQLIRLRNKYYFSNEYTEEVKEKIRELELKIAEFKDKISQLVIASATIRPKGIKQKALRLLTGFEPSSIQLYARNIIDAYTENLDLSIVKELGSGGLILVSKEYGRSKLNEIKKYVEDLGFNAKLAISGRKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIRAKLFDALSNPFTLLRVGKLIGIDFSKLQNKILILNPSEVQLLKFSIIKGESINYHKLEQLRQELLYYMSLVKDKLKEKVEDTLISDSFVITKQNGNYYIVYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDRHIFEILEKKMQKLFPNTTFTSLSNTNLSEIKIKLEDSRKEEGNRVHFNISTGLLIVESPTKAKTIAKMFSRPSVRIRNKVPVYETIIVDGNQIYVLDIVASKGHIVDLTLEDIGYYGIKVEDDGTIKPYYDLIKKCLDCNKIFSSASDKCPYCGSANLQSAQTTINLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVYRVVYHEITKKAILEALRNPKKINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVNKTIKYKSAMGHVVYIDIAGYSIKKYFSEKRKVEEYINNLQVARIEKISEEKILLSPLPPFTTDTLLIEANMKYKLPANLVMKIAQDLFEAGLITYHRTDSTHISSVGIEIAKEYLQKQALIKEFVPRSWESSEEGAHEAIRPTRAIDVNELIQEIEENPYKYSIRFSKLHLLIYDLIFKRFIASQMSHAVGTKSRYLIKLGKDDNVDVELLSNAEGGFIKVYPVKVYNLPVGEIQPKVNITKGSSEQLLSYSDVISLMKSKGIGRPSTYAKTIENLMKHGYIVSSKRKSYLIATNRGISVYQFLSSKFYDLVSESTTSRLMTKLDDIALSKLNASTVLLEIFSEISTLVNPLKSEQNV
(18) Reverse gyrase [Acidianus hospitalis W1]
6
MVTSVFLKACPNCGGPLEDYRALAGLPCSKCLPGDISPFKNLSIDEKIRLIYNILVHENKLKGYWNLYYYHQLSQEIIDYFKKITGKEPWSLQKLWLRRLVEGSSFSMSAPTGMGKTTTIIVYSTYLQNSNKNVLYIVPTKSLMQQICEKMEKIGDKTSCGKVGSGISIVTVNYINRNFEEIKEYRPDFVAVDDADAIVKSGKTVDRLVTLMGIPQEVYEDAIKLVKLKRLLAIEEKRDEIETKIAEIESRISKYYGTASQLVVASATLRPKGIKQKALKYITGFDVSTAQIYARNIIDAFTSSSVVDIVNKLGSGGLILVSKEYGKDKIKEVNESLKELGFKTAIALSGRKFLEKFSSGEIDIIIGSASYYGVAVRGIDEPKRLKYVIFYGVPKSRVRLSQAIYNPYTLLKISKLFNVNIDDNLILSLSPSEAQLIKLAFLKSQKLTGKLGEIQKILEGKIDEVKSALKAVSNEVISDTFLIRKIGKEFYIEYPDAITYLQGSGRSSRLLNGGLTLGLAITIIDDFKLYEMLKRKLQYMIYNFNPTNFDSLDIGKVKNEIERSRNDKNEELHISTGLMIVESPTKARTIAKMFGAPARRNIAGVPIYETVIVDGNNVHILDIVATKGHVADLTTENIGYYGVEIRNEDKYPYYSPLYRCMNCKRVFSQEIDKCPYCGSTLISSSMSTINAIRKIAMEVEKVYIATDPDVEGEKIAFDVAANISAYNPNIYRVKYHEVTKKGILEALANPMNIDLNLVKSQIVRRIEDRWVGFELSKLLQIKFSNRNFGAGRVQTPVLGWITKRTEEYRKNMCYVASIKLGNYTHKVFLDNKNVKIDKVIVKKMEDKDDIILPLPPYTTDSLLIDAYNLYKLPAERVMKIAQELFESGLITYHRTDSIHVSNKGIEIAKEYLDKKGLIKSFIPRSWGNEGTHEAIRPTRPIDAEELKKEIEDNPQAYFIKFTWAHFAIYDMIFKRFLASQMKEAIGKYTKYQIKVLDNVSEITVLTSIKGGFSDVLKPRIYEIPEGEIQVNPIITKGSKVRLYTYAEVIKEMKDKNIGRPSTYAKIIQTLMRHGYIVESKKKYALIATKKGINVYNYLNSKFSSLVSESTTAELLEKMDMIAGGKLNADNVLTEILGQIKSLVTSLNSEQQI
(69) Reverse gyrase [Nitratiruptor sp. SB155-2]
6
MIDLVYKGLCPNCGGDICSDRLDKGLLCKRCMPKEGEPCEVLKEGEFVKVCEVEQRSVEFEAFFKEKNGFLLRQIQKSWAKRFFLGHSFALLAPTGVGKTTFGLSLASFLDQKSYLLFPTQLLVNQAVEKLRLLGIEPLFYDSGFSKSKKDEVKAKIASGDFEILVTTTAFFYKNFDSIPKAFGFVFIDDVDSILKSARNIDKVMLLLGFSQEDIDAAMQFIDHKIKGDLSYEEFEQWQAKIEAIRSHAKAQLIVSSATANPRSRRVGLFRELLGFEVSRPSITVRNVEDLYEKPEKLWERSVELVERLGRGGLLFLPGNETKERLQEFLAFLEQKGVKAQSYEDFDAKAFEEGEVEVLVGFASYRNPLARGIDMPATIRYALFVGVPKLEFTLDITKHTSLYFFLLALLPVIRNHPNFHQFMQYVNYLKRLVRVPTERLNEKAKARVQTIYHDILAILDEELIDAINKTPDVSLVKEDEYFKIITADVTGYIQASGRTSRLYVGGLSKGLSYLLVDSEKTFSSLQKKVRWFSEEIVFKSAKEADIDAILKIIDEDRKKIALALQGKFQEAKEFFTTSLVIVESPNKARTIANFYGKPMVRDLGGIRVYEVAKEGKILSITASKGHVVDLQKQEGVYGVLRQEHFIPLFEPIDENKRRIIEALRRIGVEVQDVYIATDPDVEGEKISYDLQLLTKPYNHTVQRAEFHEVTKRAFDEALSHPRDFDENLVKAQLVRRIADRWIGFSLSQMLQKKLQKSWLSAGRVQSAVLEWIVLREKEAKEKIFVVHVSFRGLEAEFVFDEKQKAKDFYERLEVVEVRFIQKETKELFRTPFTTDAMLYAASSELHFSPQKTMQLAQDLFESGFITYHRTDSTRISSVGIAIAKEYIQSRFGQDYFVPRSHSKAGGAHEAIRPTKAMDAQELEQFLQMQNSNLTQDHLKLYDLIFKNFIASQMKSAKIEEIAAQVEAFDQKTTIRFYDEIVEHGIDLILPVQLHQLQEGRYAVQKELLTRSKVPKYSYADVIRLMKERGIGRPSTYAITIQKLQERHYIVQRRGILYPTKLGQEVYEELRKNPEVYTFVNEHYTKELEALMDRVEKGEVSYEEVVESLYLQLKERIEF
(75) Reverse gyrase [Staphylothermus hellenicus DSM 12710]
6
MVELKHIHGYYRYSCPNCAGENSDLRLIYKAPCDKCIEEELFDQIRENISKKSYKEILETYYKVLQKHNKLKKRFESLYKFEEKLEKFEEFFSRATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYLSKKQIMIQKNRASRKKVYLVFPTTPLLLQAEKKLRKLAEQARIPVCQEENHDQTCLNIISIHGRVSKKKREKLLEEIKSGNFDILLSTNMFMHRNYELLLGKKYELIVMDDVDAILRSGKAIRILFYLLGLTDQEINEAIEYLKARQRLAFRLSEEKRRELEQKLETLEKRIEKYKRKIGTIVIVSSATGKPRGIYPRLFRILLNFEAGSKAEAIRNIVDTYTYPEESIEQTIIKLAKKLGNGGLIFVPIDKGVEYAETIAELLKKNGINAEAFHAKKAVKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFSTRLETPSPTDVLRIFTILRDVLEGEEKRKAEILIGRISLRLRRLSQGALMKLKEDFIKKLQGEEVEEYPLLSMLIEALSMARELLSKPEIWEKLKQKGDVALIQEDGKSYILIPDVATYIQASGRTSRLYPGGITKGLSIVIVDDQRLLNGLTKRMRWLYEEFDMRRLDEVDLDNLMKEINEERRKVKMILEGKIEAEKTLELTKSALLIVESPNKARTIANFFGKPSIRILENGMPVYDVTTGDYVLSIIASIGHVYDLVVDDGLYNYGVRLVGDKFVPVYTDIKRCNKCGYQFTAETNTCPKCGGRDISRKLDIVETLRELANEVDTVFIGTDPDTEGEKIGWDIKVLLEPYAREIKRVEFHEITRRAILNAIRNPRDFDMKLVEAQIVRRIEDRWLGFALSKKVQKYFWPKYCVEALIPSLYKMIRKKKKKIEKMPNCCVENRNLSAGRVQTPVLGYIIERYRDHNDVSKYKYLLTIKIDDNRLRVDIDRSVLENIGTTSPRDLIGYRVEVLEGDRKEEIINPPPPFTTDTLLEEASMRLGLSTTRTMEIAQELFELGLITYHRTDSIRVSDAGINVAKQYLEEKLGEKAKEVFKPRTWGTGGAHEAIRPTRPIDADRLAELIREGALILARPLTRLHYLVYKLIFNRFIASQMIPAKIVKQILKIRINGYEKNVERVIGIIEKGFLEFYQTVNIEEEVKPGTYPIVDVEELKPPLARYHDVIKWMKIKGIGRPSTYAKIIQTLIDRRYVNVSKRVKALIPTRRGIMVYEEFLNKYYRDVVGVDVTRELEKKMKEVEEGVRDYQEVLWEIYNELRTKIIDNPIVNKELERQWSMYCGQTEYSK
(103) Reverse gyrase [Thermosipho africanus TCF52B]
6
MPVNLKFDHSCINCEKINTDDRNLKGLPCIKCLPNETNDYINSLITTNKLYKLEKYIRFENEFKDFFNFFVEKTGLKLNGYQKLWTKRVLLSKSFTMIAPTGLGKTTFGILMAIWLAKKEKKSILIFPTITIVKQVVEKIKKLDKTIKVLYYNSNMKKSEKEDFEKRFKKDDYKILIVSTQFISKRKEELKNKFFDFVFIDDVDSVLKSSKNIETIIMLTGVPENIINETLKKLKSGQKPEIKDLKKGILVVSSATARPKGIRPLLFRYIFNFNLGKPSFFSRNIIHIRYKNKEINQLIELLKILNDGIIIYAENENEAKKLKEALKKNNIEAGTSWENFEESFEKFKNGKLNILIGISSYYGKLVRGIDLPEKIKAVIFWGIPKFRIEKEDLILPDIYTYVQATGRTSRLFKGNLLKGASFVFEENDEIFEKLSSRLFWITDEEFYNYNDIDIKKLANELNESRKNIQNKELEFSSKLIIVESPTKAETLAKFFGISSIRSLNGLISFESITKEGLITITATKGHTYDLITREGYHGVEFSNNTFIPIYNTIKKCKDCGYQFVDNYDKCPKCNSKNIDDKLSVLKALRELSLEVDEILIASDPDVEGEKIAYDILQYIYPVNSNIKRIELHEITRNAFLKGIDEKREIKENLVKSQIIRRIEDRWIGFELSQKLQTNFKRTLSAGRVQSTVLGWIIQREKEYKNSIKKFTSFTFENGLKVEFEGIHENATLKIENIYEDTIAPPAPFNTSTILSEISKKYKLSVNEIMSILQNLFENGFITYHRTDSTRISKTGQAVAEKYFKLINKPHLYKPKSYGNEGAHEGIRPVKPISPEELKDMIKEKIINLDKKHLLIYKEIFNRFLASQSKEIKVKKARLNIITENSKKSEEIITEILEDGWNIFMPIKVIQIMDENKVTDRKVYNKHTVPLFTQATIIEEMKSKNIGRPSTYAKIISVLFERKYIFEDKYKRIIPTKLGKIVYNFLNSKYNKFINEETTRTLEKIMDEVEKGIKEFQQTLHEIYNEIKGGIK
(133) Reverse gyrase [Caminibacter mediatlanticus TB-2]
6
MLEAIYKNRCVRCLGDITSLRLSRGEFCDKCMQEIENLENCNELLNFKKFCEANKKLEEFNNFFKEKTGSTLNSIQKMWAKRYFLDNSFSLLAPTGIGKTTFGLLLSAFVNNSYIIFPTKLLVSQAIERFKLWGIEVLAYTGKKNEKEKIKNGEYNILITTTQFLYKNKKLINKNFDLVFVDDVDSILKSGKKIDDILGLLGFNEEDLQKAMELINKKEYEKISEIAKKKRGNLIVSSATANPKSKRILLFKYLLGFEVSRPNLTLRNIEDLFDEKFSWELSIEWIKKLGIGGLLFLPGNETKEKLYEYLEFLNNKGIKAYSYEEFNDHIDEFKKGECYFVGFASYRNPLARGIDLPQAIRYTLFVGVPKMEFNLNEDNFRSLYLILLSVFPYLMKNNLLDKKEAIEFQNYINFMKKYVFYTILHPKIEEKLRLISTKIKILIKKYENEIKNSPEISFDGEKIITADITGYIQASGRSSRFFNGHLTKGLSLVLVDNKKAFFSLQKKLKWFSEAQFKRVDEVNLEEILEEVEESRKIKKEIKLKTSFVVVESPTKAKTISSFFGKPSKRIINGVSVYEILLEDRNLVIAASVGHDFDLVEDEGDFGVIKKYIPIFKVLGEKDNILKALNLTSSEVEEVYIATDPDREGEKIAFDLTLNNKPFNLNIKRAEFHEITKYAFEDAIKNPREVDLNLVASQFVRRIADRWIGFKVSLYLQKLLKNAHLSAGRVQTPVLKWICERTSKLKEKIYIVRIIFDEIKVDFEFEDKKEAENFYNSLGEYIEIKKISSKEESLLEKPFNTSELLKEASIKLRFSPQKTMQLAQELFENGLITYHRTDSHRISSLGMSIAKEYIKENFGEEFIKLRSFEEGGAHEAIRPTSSMDSEDLRSFIAFKNLELNNEHIKLYDLIFRKFIASQMKEAKVLKETYDILGKNEEFITKIIEDGFNLIYPIKVYNVNEGKKKIEKLKLQKSKYPPYTYADIIELMKQKGIGRPSTYAITIEKLLDRKYVVEKNGYLFATKLGFKVIDIVFNSEYKEFLDEEYTAFLEEIMDKVEKGEVNYKIILEELYQKVILNQK
(164) Reverse gyrase [Acidilobus saccharovorans 345-15]
6
MCPNCGREITADRLEKGLPCAVCLPREPKSGDILEIGLELAKEGKLKGYSSLYLMEKSFRDFSKFFEEKYGFKLSSAQRSWARRLLSEESFSIVAPTGVGKTTLLMAYAAFKVMQEGYKVMYLVPTENLVAQTAGRLASMLGDKVAFYYSSLPKAQRSQMLDKITRGDYSVVVITPGFMVKNFDMLKKQSPFNLMIVDDVDSLLRNSKNIDRALILIGFDEDSIATAFKIVQEKLELVTLEASGRSEERIRQLQSDISSLSLKLSEKVLEGPKGQLVIASATGRPRGVKHLIFRELLGFEIGGGTDYLRNVVDTFLITASPVDSVVSLAKKLGKGGLIFISQAYGKAYVKELMDKLAGAGVKAVQAISNSRRAVEKLSSGEVDVAIGLASRYGALVRGIDLPEVIRYAIFLGTPAIKVELKTALLSPRRLLRALIFLEEKDSSFKEYREKLENLLKNFNVESNILSAAIRGEIEAKGRLEVLRELVLEASAKAVQALSNMIVKDGQVLRIGTMVLRREGPSIWLYSPDAPSYLQASGRTSRLYHGTMTKGLSVIVDNMKELVDAMEDRLRWMSQATFVEFNSVNLEDVTREIEASRSEKGERKQVNIVTELIVVESPTKAKTIANFWGRPAKRSEGRVSIYETTVVDQETGTVHLITITASKGHIYDLVIEGSDEVGNSLFGVRFNNAIQPVYTTIKRCLSCGYQFTENVDRCPRCGSTAIIDSKGIADTLRKLATQVDRVIIMTDPDREGEKIAWDLYLTMRPYNQNIYRSAFHEVTPRAFMEALRLPGSIDVNLVNAQMARRIDDRWIGFVTSQYLWLKMNKNWLGAGRVQTPVLGWIIDRYNEYKEVMGYKVRGLLPSGTPVIFYTKSSEEAEEASKLNVAVAVTEKVWTEDVNPMPPYTTDEMIFDASAKLGYSAELTMKLAQDLFYSGLITYHRTDSTRISEAGMAVAKQYLESHGLAQYYKPRSWGAGGAHEAIRPTRPLNAEEVERAILDGSLRVPMALSGAHYRLYQLIFERFMASQMAPATLEKASVTLRLGNLTQSMEVVIAVVKEGFTAIMRPKLETWVLRETNKEYEVPLTNVVMFKGSLIQPYRSGDLVMLMKKKNIGRPSTYAKVIEANLRHGYAVETKKLKFLIPTRLGIEVYRLLSSSPFSDMLNEEASRRLEESLDAIESGSQDAGSFIMSVREELFRKLSEANLRLR
(221) Reverse gyrase [Thermosphaera aggregans DSM 11486]
6
MSNLLNPYGFYRHACPNCGGEISDHRLFYKAPCEKCLSEGDFKKTLKRIRSEGLRDYKSIIEAYYKDLKNPEGLRQLLDEEVALEDFEEFFERATRGNKLWSAQRTWARRVLKKKSFSIIAPTGTGKTVFSLVISLYTVAKSQRGDRRRVYLVFPTLPLLLQAESKVKHFATNAGLKICEDRAEESCIRILVAHGRSDKKSKEELMEQVRNGDFDILLSTSAFFHRNFELLKNKDFALIVMDDVDAVLKSGKAIRKLLNLVNVTDDAINDGLNLIKLRQRIVFSSGEEKEKLSAEIEELEKKIARVKSEIKTTLVVNSATGRPRGIYPKLFKVFLDFEAGSKPEAIRNIVDAYIEADDPENALLEIASKLKDGFLVFVPVDRGVEYADKIAELLKAHGLKSESFHAKKKIDVLNDFARGELNCLVGVATYYGVMVRGIDLPERVKYVIFLGVPRHKFSTALEEISPTDLLRIISVLRDIAPEESKRELESLVGRLSNRLKRISQGALFKLREDFAKRLKGEHVEETVLIKELLRAYELARELLRDEEIWRKLSNLGDVGLLWENGRQYLLIPDVATYIQASGRCSRLYPGGITKGLSVIIVDDKRLLNGLNKRLRWIFEGVSIANLRELELEKLITEIEQERVIVGKILRNEYRPEGQVDLIKSALLIVESPNKAKTIANFFGKPSVRVLGKSLQAYEVTIGDYVLSIVASAGHVYDLVVDLQENYGVRRVGSRFIPVYTDIKKCVNGHQFVDETDKCPRCGTSRVVRKADIVSALKELAREVDLVLIGTDPDSEGEKIGWDLKVLLEPYAREVRRVEFHEVTRRAILEAIRNPRSFDTRLVGAQIVRRVEDRWIGFSLSEIVQKYAWTSYCFENLKDKGHDCCRENRNLSAGRVQTPVLGYIIKRYRDKEDKSLYKYRLLAEKDGEKISFTIDRAQAVNAGLVSILEKNNKRRKKDKNYPPLVIKERELIVEAKNPPPPFSTDALLEEASKSLGLATTRTMEIAQDLFEMGLITYHRTDSTRISEAGLTVARQYLEERYGDKYRDVFQPRTWGEGGAHEAIRPTRPIDADRLAELVREGVIVLTGRLTRQHILVYDLIFRRFIASQMKPAKIGKQVLTVSINGVEAVVERVVEVVEKGYLEVYQDVKLETRITEGEGRITEVVEVKPPMARYHDVIRWMKENGIGRPSTYAKIIQTLLDRRYVDVTKKHKALRPTERGIFIYRFLDEKFKEVVSVETTRRLEKDMSDIEEGRVEHMKILEKLYNELREKILDNPIIKELEDEYSERCGRKSDAA
(246) Reverse gyrase [Thermotoga petrophila RKU-1]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEESPSDIYGALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIIQGKSFTMVAPTGVGKTTFGMMTALWLAEKGRKSALIFPTVALVKQTLERLQKFSDGKVKILGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIKKAFSAIKQGRIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISTRSKEKLIELLEIFRDGILIFTQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKLNILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLEFDRAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLEMTIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEESETNWKELVHEVEESRKRIEGELTDTSKSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVVLFTATRGHVYDLVTRGGIHGVEEEDGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPATRSLRRIEMHEITRYGFKKARENVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEVEEERNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLKKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMVEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIATVELNGKRLGIEQIIEVLKNGWNLFVPLTVSPRFEHRNYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRLGVKVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(270) Reverse gyrase [Pyrococcus sp. NA2]
6
MKAIYRGMCPNCGGAITDERLSSKNPCEGCLAEPIVLQDYDKLIEAIRNALKLRDTLKDWEELYRLNKEVSEVEELFERATGFRFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYFATKGKKSYIVVPTTPLVIQTVKKIKAMLERAKLNVNLVYYHGNLKKKEKEEALEKIRNGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLMLGFSEEMINKAWEIIKLKKQLAKLLQNEGKEEEVEKLNREIEKAEREIEAYKKNNNIGILIVASATGTARGDRIKLYRELLGFEVGSGRSVLRNIVDTYLIPEKSIEEHVEELLRKLGKGGLIFVPIDRGIEYAEKLTEYLKKKGFRVELVSAKSKKGIELFENEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEDKRAEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKSAVEFLRAVLKDEEVIKRIAENPFLSLKEIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVVIVDDEKVFNGLLRQMRWRFVEFEMKRFDEVDIDDVLREIDEDRKKVRMVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRKIGDLVAYEVSIGDRMLTILASGGHMFDLVTTEGYHGVLMLKRNGKPYFVPIYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIREARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLVLENGISITIENAKGNVSEVTVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSTHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPVDTGRLIQLIRDGIITLPRNLTRDHFRLYDLIFRRFIASQMKPAKVIYEEAIISTPFGDVEVEGYIDVIYDGWSRIKPLPLKKIPKLEKGQVIKVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLMSKYKPLVNEERTRQLEKIMDMVEEAKADYQDVLNELYDEIKAYVK
(271) Reverse gyrase [Thermodesulfatator indicus DSM 15286]
6
MLFLVAHACPNCGGTISDERLNRGLPCSKCLPVPTEQDVCQALEEKGQLKRLSLFCNALSELDKFRHYFQKAVGFWPSSLQETWIKRLLLRESFAILAPTGTGKTTFGLLTSLYFAGKVLILVPTRLLAQQIGERLEEFSQKTGIKRQILAYLGKKKDKETFASQNFDILVCTTAFFYKHLDELLDLDFEFVFIDDVDSFLKRSAHIDKLFKLLGFSEREIALALKPQKTEKDFEKLEAIRKRHAGKKILLMSSATLRPRTTRVLLFRYLLGFEVQRAVSSLRNVVDAYKDMSSSDLAGLLQKAAELVKILGPGGLLFLSQSYGKDQVENVVEFLRAKGFKVLSYLELSPKEIMAQMETGDFDVAVGLAHLANPLVRGIDLPYILRYALFLGVPKHVIPTKVDLLPRSLFNVLANIIGILDEEERLKAMADLQYLRRYLTLTQENLPKYPRILERLKEIKAFVDNKFKDEAFLERLSKSEDVFLVKEGEELFLVVGDTATYIQASGRVSRLTAHGLLKGLSVVLVEDLRAFRSLERRLRFQLGEEFSFVPLENLDLKELSCELTEVRQLKRNAKGASRDFIKTALVVVESPHKAKTIASFFGKPAVRKVGEAFVYEIPAEDKVLMITASLGHVFNLSRRRGFFGVFKENSRFVPMFDSIKICEPTKEQLVDPEEVKTRCPEGRIYDKRELLESLRKLAFEIEEVYIGSDPDAEGEKIAYDLLIEMRPFNSNIRRLEFHEVTSRAFREAIKNPEEFNLNRVKAQLTRRVVDRWVGFVLSRKLWEAFGRKRLSAGRVQTPVLGWVIERADEAKQKKALISFKLFNETFNLTIEDLKLARRVFEALDELSWEILEQKEEEKNPFPPYTTDTVLQDASQRLKFSTRETMNLLQDLFENGLITYHRTDSTRISEAGRYQVAKPYITEKFGEDYFYPRAWGEGGAHEGIRPTRPRDVHEIRLMLANGLLTLAEPERALKLYDLIFKRFMASQMRPALVEKTIIRFSLPFYNWEEEIITQILRDGFEKLYPTFKVVSLSPQAGLQEKGYKLVPKVELFTEGTLVQEMKRRGLGRPSTYAEIVTTLIQRKYVKVLPGGRLTPTRLGREVYEFLRKNYPQYTDEALTRELEEAMDLIEEGKLDYQKVLAEAYRIRRLLSGEPEEHAFEERLTTYQRDF
(276) Reverse gyrase [Caldicellulosiruptor saccharolyticus DSM 8903]
6
MATGAKYYHSCINCGGINSDTRNQKGLPCEKCLPFENNMNILESLKEHNSLKDYAYFWNFQNEYKEFEKFFVSKVGKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWMAKNGKKVALIFPTVSLVEQTHQRLLEFANKEPKENVKILSYKSSMKRTEKDEFEKNFENGEFDILIVSSQFISKRKDDLAKKVFSLVFVDDVDAILKSSKNIDTLLQMIGIDQKTIDKTFENLKKGVKYPEQKQNGTSSTPSKGILIVSSATAKPQGLKPLLFRELLGFEIGRFTFSVRNITNIRIAGKSKVKLLETIKILNDGILLFVENEEEGKDVTNFLENEGISVGKTWEDFEKSFEEFKDGKLKILCGIYSYYGKLVRGIDLPLRIKYSIFWGTPSFRFSTDIEKAPRFVLERVFSDYLEEHPKLKSFFKNIDKYQVERLREVVKKYIPQDRWTDFIKKSFSNLKISDEGQIFFPDVFTYIQGSGRTSRMLGSSLTKGVSILFEDDDLLFESLRSRLMFLLDEEWKTEDEVCFEDLIKEVEMSRNEALIDERSSDLKSRLMIVESPTKAETISRFLEKASTRRYGRLSVYESVTPDGILLITASKGHVYDLDTKTGVHGVEISNGNFIPYYNSIKRCTSCGTQFTDEYSSCPKCGSDKIDDKKEILKVLREIAAEVDEILVATDPDVEGEKISWDISQYLKPVNPNLRRIEMHEITKFGFESAIKNQRDFNANLVKSQIVRRIEDRWVGFELSSKLQKNFQSYNLSAGRVQSTILGWIIEREKEYAKSQKEFTFVRFENGFGFEAEGKIDGDKVLVDVVEENEKELETILPFNTPTLLSYASQKLNLSVQEIMEILQFLFEHGFITYHRTDSNRISLTGQNMARLYLEKIGKKDLFVGRSFGSEGAHEAIRPVKPISPLELKELSSERLAQGLTANHIKVYELIFNRFFTSQMKNPLVRYQKLIFRFDKQEIEKEMPIEVIEEGWLLFSPIQIFSKFESGEYQIIEKKNYKKHTTPLFTQAMLIDEMKQKNIGRPSTYAKMVEILFKRGYVFEDQYRRIRSTALGRKVYSYLAQHYQDYINEETTRDLERLMEVVEIGEKDYQSVLSSLYEELTKIMQR
(293) Reverse gyrase [Desulfurobacterium thermolithotrophum DSM 11699]
6
MKLAEFHRMCPNCGGIISDERLKAGLPCEKCLPKELFYTNRKEICNALGNKLQDFKKICLLDEFTENYVKFFKEKTGFTPWTLQVMWARRVALSKSFTMIAPTGVGKTTWGLVTSAYLSGKVYILVPTKLLVLQTVEKLSKLTNKKIVAYTGKKSEKGTIQSGNFEILVTTTNFLYRNFEIIPKPFDFVFVDDVDSLLKSAKNVDKVIRLLGFTEEDISIAEKVLELKSLVAKFGEKVDRKLIEKLKKLENFLEKRKSEIKNVLVVSSATSQPKSKRVKLFRELLGFEVGKSATALRNVEDVLIYTDKDYLEETVKIIKKYGKGVFVFISEDLGKDYVEEVVNFLNKKGISTVSYENFSSENQGNFIDGKIQAVVGIASYRNPLARGIDLPQAVRYAVFLGVPKLEFNLKLSLAPVKLFGILLVLRELIEDKTKVMSYLSYLKKYLSLKKELLDKYPKVKEKLEEIKGFLESYLSNKEFLEKVRASEDISLKEKNGELFVVVGDATGYVQASGRTSRMFAGGLTKGVSLMLVDDLKALNSLKKRLSIFLEDLNFKVLDYDKGKELAEKFGFELIDEEKLNKIFKTVDEDRKRVKEILEGKIKAETKNLVNTALIVVESPNKARTIANFFGKPVRRKVLDIDVYEINIGDRLLLLTASKGHVFDLTVRDGLWGVKEEESSYIPVYDTIKYCTKCFEQTTEPFCSKCSGKPDVDKITVVRALREVGLEIDEVYIASDPDTEGEKIGWDIGTVIKPFQKKVRRMEFHEVTKWAFMEALKTPKEIDENLVKAQIVRRIADRWVGFALSQHLWKVFKKHWLSAGRVQTPVLGWVIKRYEESKEKKGIIVVETKAGSFRFEFDNLEEFQKIAIDKVEIKVKEKSIFEKNSLPPFNTGELLKEASNNLGISAEETMNIAQALFESGFITYHRTDSTRVSTAGMGVAKEYISQKFGAEFIKLRSWGDGGAHECIRPTRPLDAESLKALVLVSGSSSKMTKNHFRIYDLIFKRFMASQMIPTKVEKCKLLVKLLPVEKEEEEERIAKIVKNGWNLIQPLNLEPLSVELKKEKTYYFEIISYVKKKVPKVFPYTQGELIEEMRKKEIGRPSTYAKIVQTLLDRKYIIEKGKFLYPTKLGIEVYNYLSEKFPDYTSEEFTRELENIMDKVERGEEDYQKVIENLKPILEIRYS
(324) Reverse gyrase [Hyperthermus butylicus DSM 5456]
6
MGELSTDYYERIETIGRLLAENGRLRGYWYLYSSTSQLREFEEFFEKLTGHKLWSAQRTWAKRMLQGESIAIVAPTGVGKTTLLSVYAVYRASQGLKVYYLLPTENLARQVTRKLETLSSRLGGGIRVVSYYSSLPKRAKEESLRTIEERSYDILVTTTAFLSRRWSLIEGIRFDSILVDDVDAVLRNSKNIDKLLQALGFSVEAIEAAYNLVKKKIMATIAKTSGNIKRYEKLLQDIEQLEAILSQELVKTTPGQLVIASATGRAYGLKPKLFRELLGFDIGRVYDYTRSIANLYKIVNDPVAEAVSLVTRMGGGGLVFVAKRFGKNVARRIAEMLNERGIRAAVALAGRRVLDRFASGEYDVLVGVASYYGVIVRGIDMPERIHYTVFVGVPSQAIEAGKALLSPHRIARSAVELSLEGAEELARRLSKLAPNEVTVLRIALERGERLEGRLGEILEMLLETRRKLLHAIEELVSIEGSVAVGGALYRFEDGKLVAILPDAPTYVQASGRASRMYGSAMTHGISIVLDVDEILVRLLAEKLKRFLEDVRFEELSSEKLAKELEKARASRRGGVGKKVDIETCLIVVESPTKAKTIAGFFGRPVRRRIGSVVVYETTFYNPVSGKIHVAAIAATAGHVYDLTIDDEGIYGVELGKNGVSPIYKPIKRCLSCGHQFSSSSQVCPRCGSSNIVSKEDVIGALRQLAIENEVVYIATDPDVEGEKIAYDIYLLLRPYARKIMRIELHEITRSELNRALANPREVDVRLAEAQMVRRIEDRWIGFGLSQHLWQVFGKNWLGAGRVQTPVLGWIIERYSEWRSNLGYNLYIRLPGGPLVKIHYDSASGAREAAAAAENGVRVVSVEEEVVEINPPPPYTTESLIYDASRLYGYPAQKTMRVAQELFEAGLITYHRTDSTHVSGLGQHIARLYLESREDAELLQPRSWGPQGHHEAIRPTRPIDAEALRRMVALGDLRVPVTLRESHYRLYDLIFRRFIASQMKPAKLKRRRIRLEVAGSQVEIEVYTAALREGYHKYYPYPRLHMALDSVKPGDVLRPERILVRRGSTVYLYTHGEIVSLMRERGLGRPSTYAKIIDALERHGYVIESKYRRRLVPTKLGIEVYEYLESRYGSLVSEERTRKLYRDIEEIASGNKSPVEVVNELLAELSELLETSLRQYTGEVKALG
(328) Reverse gyrase [Thermotoga thermarum DSM 5069]
6
MPLAIYKEFCPNCGGEIEAERLEKGLACSKCIPDEISETELCEILARKSELKNYSWVCCLKSLERQFCDFFTKNLGFEPWALQRLWAKRVLSGESFTLIAPTGVGKTTFGIAMANFLPGKAYILLPTRLLVEQVAERCKTFKAKKVVAYTGKTSERKTIEAGDYEILVTTNMFLATNFELVQDQRFSFIFVDDVDSLLKSGKNIDRVLKLLGFTDEEISQAWQKVSGKLLEEKEEETMEEEEENILEESSQEDEFNEENVLQTKGKGILVVSSATLKPKTQRVKLFKSLLGFNVTPVKLTIRNVCDAVEWVDGPQQALYRLADWIRFFGKGGLVFVNREMGKDGVTTVVDFLKQQGINVSSYEELDLESMRNGLIDVAVGIATYNNALVRGVDLPEVIRYAIFIDSPKISFAIEQFDNPRNFVPLLLALREVVEDKSKIDLYLERLRRYQVFKFEKQLPKPLLEIAEYLRKNLNDESIVEKLEKAETIGLQRKEGKLFITFGDAANYLQASGRTSRLYPGGISRGISLILVWDKKAFHSLVQRLRLFYEEVDFLSADQVNWEEELKNVDADRKKIREIKKQFKPSEQLSLKSTLVIVESPNKARTISHFFGVPQQRILNGLHFWEILTGDRLLSITASIGHTVDLIEREEIYGVSKANGHFVPIYSTIKTCSKCGQQTTSEICSCGKQPDKDKLTLIKALQQVAPQFDEIIIATDPDMEGEKIGYDLMVALKPFNSNIVRAEFHEVTRQAFLKALNSPRELSKDLVKAQITRRILDRWVGFYLSQELWKAFKKYNLSAGRVQTPVLGWVIDRTNSARQKKAKLQISVKSILEGKTAALIYEHEDINFAKQLVSMLQQAQVTLEDVGQETENPPAPYNTASLLSEMGAFASAVDIMNTLQELFEQGLITYHRTTSTRVSQTGIKLAEEFLKQMGLHQIFHPRTYGTEGAHECIRPTKLLNVDDLKLWIHTGRVKFENQNLALQLYGRILNRFLASQSAPAVVQKSKLTIKLPDWSYEWTLTTKIIEPGFRTILPAKVFDLKPPLKVVWTTLRLVAKELPFTQGSLVQQMRERGLGRPSTYATIVQTLLDRKYVEERNGYLYATPLGYKVYHWLRTNYPQLTDESLTRKMEDVLDEIEAGNADYQSFLSEFYRDFLQKVFENKT
(334) Reverse gyrase [Sulfolobus acidocaldarius N8]
6
MLKVNYLFGCPNCNGSISVDRLHAGIPCETCLPGAVEKLDIRTIYDLLVKYSTLKGYSELYMDLEMYDDILRLFKKIVGGEPWSLQRYWLNKLVRGESFSLSAPTGVGKTTTLIVYSVYSHTTSLFVVPTKSLRDQICEKLKKIGHLVSCNKPEEDKVNVVTFHSINKNIDEFVRIKPKLLMVDDADMILKSGKTTERIAKVLQIPQEVFDDTIKMLRLKRMLRFKEDEDLINQVRELESKILGYKSSVQFIVSSATLKPKGYKQMALRFLVGFEPSTIQIYNRNVIDSFTYSNNVNELVKEIGDVGGLILVSKDYGKKYVDQITDNLNAEGYRAMKAISGRKFLEKFSNGDVDFLVGSASYYGVAVRGIDEPKRLKYVIFYGVPKTKLPLEDSLNNPLTALKIGELLKLDVTEYRKRLIYLSPAELQAVKIALRNKVSLNGKLGDLVEDLTKLKDIILDTIKANKIDKLVSDSFVIKKDTNKHYIFFPDIITYIQGSGRSSRIMNGGLTLGLSVVLVDDLELFDILNKKLRRIAEVTFMNFDELKLDEVREKLNKSRSDGSGGRSMNFKTALLVVESPTKARTISKIFGRGVRREIYGIPVYETIIIDDHSNTIIYTNIIASKGHLTDLTTEELGYYGVEINDKDIVVNYSPLYRCMSCGKTITKKVSTCPYCGSSMINSSEKIVNAIRLISTEVDEVYIATDPDQEGEKIAYDIYSLISPYNQNIFRISYNEITKTAVLNAIKSKAKINESLVKAQIARRIEDRWIGFELSSVLRSALNDNNNGTGRVQGPVLKWVVGKTSEYKANIGYVVDINIGDYVVRKFFKTKKDAETFISQLNVKVTKIAERTSTIDPLPPFTTDSLLIDAYSKFRINSSLAMKVAQELFEAGLITYHRTDSIHISPYGISIAREYLEKIGSNDFVGRSWGNEGAHEAIRPTRSMDVEELRKEIEENPFQFGIKFTWAHYRLYDLIFRRFIGSQMSSATATYTTYEININGELYTVELPTKVHGGFSSIYGIRVYNLDESHLTTRIRKGSLVSLLTYADVIRLMKDTNIGRPSTYVRTVQSLIRHGYVVESKKRSFLIATNKGQKVYEILNKYFSDMVSESRTSHLITKIDKINRNELSAEDVIMDLLNEIKNIKLVNPLQSEQYV
(353) Reverse gyrase [Archaeoglobus veneficus SNP6]
6
MVEAIYAGLCPACGGDLKTSEAKTGKCSRNIPLCRFAGDEVVEEFIEFFRNAIGEPRAVQKFWARRILRGESFAAVAPTGIGKTSFGAAMALFLATKGKKSYIILPTTLLVEQVAESLAKYGEKAGVKVSLNNSDGITVLYYHGRMGKAEKEKFFELIQNADILVTTTQFLSRHFESIKRTFDFVFVDDVDAILKASRNVDRVLMLLGFRKTKKGWEGEARGVLMVSTATAKKGQKIKLFRQLLNFDVGSSTHAVRNIEDIAVEKDDVETIASILEMMGTGGIIYARNTQDAEMLYEALKEKFKIGIVTSGRKKDYELFESGEIDYLIGTAYYYGTLVRGLDLPERIRFAVFVGAPTFTVKLEDVESASPGIIRILALIFRDSEEVKEYLSILPVIDKPEHEKELAELRKILKKLVEEGKAKEKDVVVRKGEVIFPDLRTYIQGSGRTSRLFAGGITKGASFLLESDEEVRNAFVERAKHYDIEFKRMEEVNFEELIKEINESRVAFRRRKEAGDVVKPTLFIVESPTKAKQISRFFGQPSVKAFDGIIAYEVPTAKRVLLVSASLGHVTDLITNRGFHGVEVNGHFVPVYASIKRCRQCGYQFTEERQNCPKCGSEDIDDSKRRIEALRKLAHDAGEVIIGTDPDAEGEKIAWDIQNLLAGCGEIRRAEFHEVTRRAVSEALENLRSVDENLVKAQIVRRIEDRWIGFVLSQKLWKAFGSTNLSAGRAQTPVLGWVIERAEQHREKKVIGFIRDLELSIEGLKAKKARLRIRLIEEKEEEKTPLPPYTTDAMLRDANAILKIPAKEAMAIAQTLFESGLITYHRTDSTRVSEAGMRVAREYLGEDFVAREWFAEGAHECIRPTRAVDKNTLQRLIQENVIAVEDITWRHLALYDLIFRRFMASQCKPYTVRVCRYLVEANGISVEEERVIDARGKAYELYKAVWVRKPLPEGEVEVDVEVRRVPKVPLYTQSDLIQLMREKGIGRPSTYATIIDKLFQRNYVVERNGRVMPTKRGMDVFGYLVRRYAKFVSEERTRILEEKMDAVERGELDYLKALEELYAEIKEITA
(372) Reverse gyrase [Pyrobaculum islandicum DSM 4184]
6
MDVPHVVYLHSCPNCGGPITSDRLAAGLPCYECLPKEPQAKAIGEVVEALRRRKALKELARVAEYLREYNKFSAFFKEIIGYEMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFILVATLYMALRGKKTLLIFPTSALAHQAYKKLMSFAEKVGASVKTLAYHSLLTEKEKDEVLAAIERGEFDVLIITSAFLPRRFDLLSRYKFEFIAADDVDSILRATSKNIDRILKLLGVSDEVLKTALDIISLTKQIRKAEVVGDLKEVERLEQELSSARAKLQEEVRKLKLGIFIASGALAKARRTTRLLLFRELLGFDVGGRAEGLRNVTDVYIDMSQDVVMQTIEILKRLGPGGIVYVQDRELGIAIAEKAKERGLSVEHFFKPRRGILESFEKGEIYALVGLASPRSPLVRGIDLPHVIRYVVFVGVPKYRFRVRLEEFSIPAYLTFLYNVRTVLTGELRYKADRLIGQLKRLAPYAISVQEALRKASEGAELTGFDRHVVDVVKSAVDFVNNLLMRDDLRQAIESSTEVKLTRIDDEFYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDKKVFHALKRELKLRFDEAEFKHIDEVDLNAVLAEIDKDRKAIRDILEGRVTPATKGVELLKTVLMIVESPTKARTIANFFGRPSLIVTDGVPIYEVSTGDAVLMITASLGHIYELPTSLKRIDSRQREILAKWFGEFKYDSYNGEEYAVIVKEGSFIPVYNKIWRCRNAVYIDDTDVPPDCKPLDVLSAIRNIAIEVDTVLIGTDPDSEGEKIAFDLYLGLRPYVSDIKRVEFHEVTRRAILNALANPRDINYSLVKAQIVRRVEDRWLGFGLSKILQTKFGNPNLSAGRVQSPVLGWIVKTYEESLKNRVYNVDLQLDAAYCVEPSSCVLRLQIPGDILQTLKKKKRVAIKKESEEERVVNPLPPYTTDELLRDAVNRLGLSADYAMKVAQDLFESGLITYHRTDSTRVSAAGIAIAKEYITKRFGEGVFKPRSWGEATEGAHEAIRPTRPLDVEELRGLVNAGVIQLAIQLRREHYQLYDWIFRRFMASQMEPSVVKAIKYVIEIDGHSLELERVVETIRPGFQQLYPLTPVEPELPTGTIEVAIKRYRVVRKVLSQADILALMRQRGIGRPSTYARILQVLAKRYYVYVVGRRKLMVPTKRGIEVYHFLENNFSNLVSEERTRLIEQYMDAIEVGNAEYEGVLKELFDEFTREILSRAPLT
(381) Reverse gyrase [Thermococcus kodakarensis KOD1]
6
MKAVYREMCPNCWGRISDERLVMRNPCEECLDEPVHADSYFQLVSAVRNALKLRGTLKEWEKIYQLENQTREIEEFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHALKGKKSYIVVPTTPLVIQTVRKIEGIMENANADVRLAYYHGNLRKKEKEEMLERIKNEDYDILVTSAQWLARNYEEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFTDEIIQKAWEIIRLKKQMSRYLNGNSEDRNEKLNGLNREIEKLQREIEKFKRKNKIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTKDIKEHVEELLTRLGKGGLIFVPVDQGLGYAEELANYLSEKGFKIELVSSKNKKALEKFENGEADYLIGSATYYGSLVRGIDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSEEDRRQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLRDEEVLRKLAEDPFISLVKEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEFKMVPFEELDLDEILRQIDEDREKVRLVMEGKISAKVKDLVRSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEISVGDRMLTILASGGHMFDLVTNEGYHGVLIQNEGDMLKFIPVYDTLKRCRDCGHQFVDWEKKGVCPRCGSTNVRDALENVIAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRIEFHEVTRPAIMKAIQEARDVNENRVNAQIVRRIEDRWIGFELSQELQRVFESYNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTIELGKDGKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTLVSLADGRIMEIKDAVEKSEGNLLSVNGLKPKEAKALKFWEIDWNGPLKVIKLKNGHEIKATPDHGLLVMREGKLGWVSAKNVREGDYVAFAYNTGHRGRDEYTLLKLMIKLGITDVMVELDEEYFNEKVAPIVRERISTSTKYKYLRRRVLPLYLLQEWGLDDYEAHVKSLYRQRAGSKPIPNFKLDGRFWYVFGLVLGDGTLRDSKVLISQTPLKDVKSVLEDVFPFLRVFETTNQVGFSNSIIAEVFRRLGARKGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNDRKGPNFRGILTSKRGDVLRMLSVYLYQIGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYLRIRRAQFDEAYSVYRASRRAFEGDLLPVAPVFGKLKFKNGTKNRILKETGIDVWNWLKRPEGEIPRDKLSKVLEYAEESPEKEFLKSLVEAGVTWVKVKGVEEELYTGKLYDFTTTTENFLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPRPWGEEGAHEAIRPTRPIDTGRLMQLIRDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKAELEGYVEIIEDGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVETLMRRGYVVETKGRKKLLPTEKGIKVYHYLVSKYRDLVSEERTRELEEIMDRIEEGIEDYIKVLGELYSEIQRYVSG
(382) Reverse gyrase [Thermococcus kodakarensis KOD1]
6
MKAVYREMCPNCWGRISDERLVMRNPCEECLDEPVHADSYFQLVSAVRNALKLRGTLKEWEKIYQLENQTREIEEFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHALKGKKSYIVVPTTPLVIQTVRKIEGIMENANADVRLAYYHGNLRKKEKEEMLERIKNEDYDILVTSAQWLARNYEEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFTDEIIQKAWEIIRLKKQMSRYLNGNSEDRNEKLNGLNREIEKLQREIEKFKRKNKIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTKDIKEHVEELLTRLGKGGLIFVPVDQGLGYAEELANYLSEKGFKIELVSSKNKKALEKFENGEADYLIGSATYYGSLVRGIDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSEEDRRQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLRDEEVLRKLAEDPFISLVKEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEFKMVPFEELDLDEILRQIDEDREKVRLVMEGKISAKVKDLVRSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEISVGDRMLTILASGGHMFDLVTNEGYHGVLIQNEGDMLKFIPVYDTLKRCRDCGHQFVDWEKKGVCPRCGSTNVRDALENVIAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRIEFHEVTRPAIMKAIQEARDVNENRVNAQIVRRIEDRWIGFELSQELQRVFESYNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTIELGKDGKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTLVSLADGRIMEIKDAVEKSEGNLLSVNGLKPKEAKALKFWEIDWNGPLKVIKLKNGHEIKATPDHGLLVMREGKLGWVSAKNVREGDYVAFAYNTGHRGRDEYTLLKLMIKLGITDVMVELDEEYFNEKVAPIVRERISTSTKYKYLRRRVLPLYLLQEWGLDDYEAHVKSLYRQRAGSKPIPNFKLDGRFWYVFGLVLGDGTLRDSKVLISQTPLKDVKSVLEDVFPFLRVFETTNQVGFSNSIIAEVFRRLGARKGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNDRKGPNFRGILTSKRGDVLRMLSVYLYQIGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYLRIRRAQFDEAYSVYRASRRAFEGDLLPVAPVFGKLKFKNGTKNRILKETGIDVWNWLKRPEGEIPRDKLSKVLEYAEESPEKEFLKSLVEAGVTWVKVKGVEEELYTGKLYDFTTTTENFLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPRPWGEEGAHEAIRPTRPIDTGRLMQLIRDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKAELEGYVEIIEDGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVETLMRRGYVVETKGRKKLLPTEKGIKVYHYLVSKYRDLVSEERTRELEEIMDRIEEGIEDYIKVLGELYSEIQRYVSG
(392) Reverse gyrase [Thermovibrio ammonificans HB-1]
6
MKVAEFHRMCPNCGRIISDKRLKAGLPCERCLPEFLKWKEREEICEAIEELQNFQQICRLDRFVKEFTEFFKEKTGFTPWSLQIMWAKRVALKKSFTMIAPTGVGKTTWGLVTSAFVKGKVYVLVPTKLLVLQTVERLKKLTDKKVVAYTGKKREKETIASGEFEILVTTTNFLYRNFEIIPKPFDFVFVDDVDSLLKSAKNVDKVIMLLGFTEEDVELAMKVIDLKAKAAKSSGRELQKLLERIKRLEKHLERRREEIDRVLVVSSATSQPRSKRVKLFRELLGFEVGKSATALRNVEDVLIFTEKDELQLAVETVKKFGKGVFLFVSADRGREYVDRVVETLNSNGIPAVSYEEFTPENQQRFVNGEIWAAVGISSYRNPLARGIDLPQAVRYALFLGVPKMEFGVKLSLSPVKLFGLLLVLRELFSEEELPKVNGYISYLKRYLTLKEELLDRYPKIKSRLQEIKEFLEAHLSNPEFLKKIRESETVSLKEKNGELVLVVGDAAGYVQASGRTSRMFAGGLTKGVSLMVVDDVKALNSLRKRVMLFLEDVEFKVLETDKGKEFAGKLGLPTITEEELKAVFKQVDRDRKRVREILEGKVTPETKSLVTTALVVVESPNKARTIANFFGKPVRRRVKDVDAYEINIGNKLLLLAASKGHVFDLTVRDGVWGVKEEDGHYIPVYDTIKYCTKCNEQTTENFCTKCEGRPDVDKITVVEALRELGLEIDEVYIASDPDTEGEKIGWDVGCNLKPYQMNMKRMEFHEITKWAFLKALEEPREIDENLVKAQIVRRVADRWVGFSLSQHLWKVFNRRWLSAGRVQTPVLGWVIERFEESKEKIGLLTVECEGVSFTFKLEEPQKLKEVKADKVKVKVREVSVTEKNPKPPFNTGELLKEAADRLKLSAERVMEVAQELFESGFITYHRTDSTRVSTAGMGVAKEFITERFGPQFVKLRPWGEGGAHECIRPTRPLDAEGLRTLVTVSGSTVKMERDHYAVYDLIFRRFIASQMVPAEVERVKAEVKLLPDELQKEEEFTTKITKDGWNLILPQIEVTELPFEPTEGESYYLPVKAVHKRLIPKVLPYTQGELVEEMRKRRIGRPSTYAKIVQTLLDRKYVVERRHRLYPTKLGIEVYNYLAENFPHYTSEEFTRELEELMDKVERGEADYQKIIEELKPVLQFANVDPKQTVGE
(402) Reverse gyrase 1 [Sulfolobus tokodaii str. 7]
6
MLKVYYTFGCPNCGGPIDDEHLLAGVPCSKCLPGRVENLDYRVIYDLLVKNSTLKGYAEYFYDNETFEEIVRIFKRVIGNEPWNLQKYWIKRLAKSESFSLSAPTGLGKTTTLLVYSLFFSNTTLYVVPTNSLKDQICERLRNMGAKVSCNDVKEEYINVATFNRILRHYDNYVSLQPKLVIVDDSDMILKSGKTTEVMAKILGISEEIFQYAISLIRLKRILKFNEDDKELKNKIVELEYKIGSWKPFVQFLVASATLRPKGIKQQALRTLIGFEPSTIQTYLRNIADLYYQGVDIEAILDKISDNGGLLLVSKEYGREKMLELKEIIEKRGYSTGLAISGRKFLNKFTEGKIDYLIGSASYYGVAVRGLDEPKRLKYVIFYGIPKIRLNLTDALNNPSLIVKIGELLNIDVKDIRRKLLFLSPPEFQILRYSLMKDEELSGKLKDIKVNLINIKEKIWDVLKSDNIKKLKADTFLVTENNGKYYVYIPDTVTYIQASGRSSRIISNGLTFGISIVLVDNIDLLDILSQKLKKIIPNFMFKNINEVDIRELKSLAVSSREVSTSQKKKINIKTILLIVESPTKAKTIARLFGRPSRREVHGIPVYETIILVNDEILITNIIATKGHITDLTTENIGYYGVEVGNNEFNAYYSPIYKCYNCGKTFTIKSNTCPYCGSVFISSSEKVVSALRKLSTEVDEIYIASDPDQEGEKIAYDVAMLISPYNKNIYRIKYHEITRNGILNAILNKGKINMNLVKSQIVRRIEDRWIGFELSLALKSMFYERNHGSGRVQGPVLSWIVERTKEYKKNYGWILYIKLGDYAIKKFFRIKEEANKFIEKLNIKINLISERKEIQNPLPPFTTDSLLMDAYDKLGIGSQIVMKIAQDLFESGLITYHRTDSTHVSALGISIAKEYLESKNLNDSFSGRSWGNEGTHEAIRPTSSMDTESLIKDIEDNPNKYFIKFTKYHLRIYDLIFRRFIASQMKPAEVTYSKFEIFINGEKLEVELPTKISGGFSIIYPLKTYVVSEKYSTYLTKGSIIPLFTYAEIIKNMKEKEIGRPSTYAKTISALIRHGYVVESKRKALLIATNKGIKAYEFLSSCCSDLISENRTKLLLQKIDKIANGDVNVDYVLEDLHKEITQISGKLVNSLKLDTNV
(403) Reverse gyrase [Pyrococcus yayanosii CH1]
6
MKAIYRGMCPNCEGRISDERLSMKNPCESCLDEPVGEQVYFDLIKAVRDALKLKGTLKEWEEIYKLNKAVKDVEKFFEKATGFTFWSAQKTWVKRLVRGRSFSIIAPTGMGKSTFGAFMAIYFAQKGKKSYIVVPTTPLVIQTVRKIRTMAERAGVEVNLAYYHGNLKKKEKEDMLAKIRDGNFEILVTSSQFLATRFDELLKDKKFDFIFVDDVDAFLKASKNIDRSLILLGFTEDVIAKAWEIIKLKKQLAKLLQRGNIEDIERLNSQIERLEEEIEAFRQKNNVGVLIVASATGSARGDRIKLYRELLGFEVGSGKSVLRNVVDSYLIPEKPVEDVVAELLQKLGKGGLIFVPIDKGIEYAEKLTEFLKERGFRVELVSARSKKGLELFERGEVDHLVGVATYYGTIVRGLDLPHLIRFALFTGIPKFRFSLDLEQPTIYRVLGLMSEIIEFLPEEDRRTGEKLYSRLRKIIRNVPQFELMKIEEALAEGLPLEGFQNHVLEIFREAVEFLRRVLKNEIVLKKIAEDPFLSLKREGDKWFIEIPDVRTYIQASGRTSRLFAGGITKGLSVLIVDDEKVFNGLVRQMRWRFTEFKMIPFEELDLEEVLKEIDEDREKVKLVMEGKISAKVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGDLVAYEVSIGDRMLTILASGGHMFDLVTNEGYHGVLIQKKEGRPFFIPVYDTIKRCRDCGHQFVDWEEKGACPRCGSKNVHDALENVKAMREIAQEVDEILIGTDPDTEGEKIAWDIRNVLAPYAPVIKRIEFHEVTRPAILKALREARDVNENRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWVIQRYKEFTESETDFLNITLENGLSITLEGAKGKVGEVIVEDVQVEERDVNPLPPYTTDTMLQDASRILGFSAPYAMQLAQDLFEAGLTSYHRTDSIHVSNTGIEIAKEYITQEIGEGYFQPRPWGQEGAHEAIRPTRPIDTGRLIQLIRDGIITLPKNLTRDHFRLYDLIFRRFIASQMKAARVLYEKAIINAGLGKAEVEGYLEVLFDGWSRIKPLPLKQLPKLEPGQRIKVKELKHWRAPKVSLYTQGDLIALMKERRIGRPSTYAKIVQTLLQRGYVVETKGRKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEELMDMVEEARADYQEVLNDLYKEIQTYVR
(406) Reverse gyrase [Persephonella marina EX-H1]
6
MSAIPIVYKDICPNCGGEITAERLEKGLLCESCLPEEIPREDICGILGYGRFVSICELWDKVNDFKSYFKGIINNDLWSIQETWTKRFFLNISYALLAPTGIGKTTFGLVLSKYLSEKEGKKTYLIFPTQVLVNQAYDRLVSFGMDPEKLLAYSTKFAKTKKKQEELKEKIKNNQFDILITTTMFLYKNIDIIPKGEFSLVFVDDVDSVLKSAKNIDKILMLLGFSEEDIQDTLKFITFKQKIFRQGQPEEKDLEIFNRWQEKINRISQKRKGVLIVSSATSNPRSKRVNLFRELLGFEVGRPSLTLRNIEDLYEKPDDVWETSVERIKKLGSGGLVFLSSSETRETLERYVKFLNEKGINAISYEDLMDSLEKFRSGEIPVVVGFASYRNPIARGLDLPDVIRYALFVGVPKLQFNIRFEEEFIHLYYFMLTLTPFLIKKKLIDPQEVRQLYEYINFLKVYAFIPEEKLDREKAERLREIQVYVKSIVEKPEVFDQIKDSPEITLKKTDEGFILITADVTGYIQASGRTSRLYAGGLTKGLAYLLVDDDKAFYSLQKKVRWFSEDIQFKPADQVDLEKILKEIDQDRENVRKVLSGEIIVEERQSFKTTVVIVESPNKARTIANFFGKPLRRKLKGIDAYEIAIGDKFLTIIASKGHIFDLNKEEEYFGVRKNSHFIPVFEPIDEGRKHIIEGIRELDLEVQEVFIATDPDTEGEKISYDLYLLSKPYNFNVKRAEFHEVTKKAFLEAVENYRDIDKNLVKAQLLRRISDRWIGFTISQYVQEKLHRHYLSAGRVQTPVLEWIIERTDQAKQKIAVVRVFIDNIPVEFSFEDRNRAKWFYQNIQFVIVSVKEKKEEKLFVRPFSTDTMLTASARELGFSPQETMSLAQDLFEAGLITYHRTDSIRVSDAGVFVAKEYIQENFGSEYIKIRTYSTYEGAHECIRPTRAVDADELRSMVYTMNLQGITRKHIRLYDLIFRQFIASQMREAVVEKVVYSVRAFDEEVETDLITDIIQHGYDLILPIRTDKLPEGKVDIKKKSYHLKPKVSYYTFGEIIKEMKEKGIGRPSTYAITVQKLLDRHYIIERRGYLFPTKLGRQVMELIKRREDIYRFVNESFTKELESLMDRIEQGKADYEKELEKLFKELEEKKLFFKVEIGKYSYEE
(431) Reverse gyrase [Pyrococcus abyssi GE5]
6
MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIRS
(432) Reverse gyrase [Pyrococcus abyssi GE5]
6
MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIRS
(471) Reverse gyrase [Vulcanisaeta distributa DSM 14429]
6
MEKQPLVIYRRACPNCGGDITSDRLASGLPCHRCLPDVPKKVASTIEVLNMLEKLGTINRLRSLANLVNEYNEFADMFRKIIGTNMWGAQRLWARRIIKGKSFAIVAPTGSGKTTFGMIASLYVALKRRGRVLIVVPTSTLAYDVHRRLSDYVNKMGVNVRIVMASSILSKQELTEAMKTIEDGNFDILIVTNAFLPRHMDLLSRYRFSLIFVDDVDSVLKASSKNIDRLLLLLGINEEALRKALTVVDLMKKLRKAIRFRASEEEINKIREDIKRLNAELTNYIKSNNIGILIASGALTRMRRTARLFLFREFLGFETGGRAEGLRNVVDVYVRPRDSLISTAVDIVKRLGSGGIIYVPPDLRDIVDELLEALNKNGVKAASYLKPSKSLLNDFVEGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMRFRLRLEEFTPIRYLMFLFTIRNVVPQYLRNDIDRVVARLRNLTALNQEQINNLLKAIEENKELSGFDKYAADVIKEAVDLVNKLLSDPNIRKAIEQSNEVGLEYRGGELYVIIPDVTTYIQGSGRTSRLYVGGVSQGLSVLIVDNEKVFNGLIRNLRYRLEDVKIQDINEVNIDDLMKRIRSERDLIRNIMLGKIPNQFLEKDPLRTAFVIVESPTKARTIASFFGVPTRRNVGPLIIYEATLGNLYLLITATKGHMWDLIPAGPADVKELAPALRAGKIIDYYGILKTGNNFVPIYGTIKRCPVGGETYTEDVDVCKIHGVKLVDAMDIVNAIRDIATEVDQVMIGTDPDAEGEKIAWDVYMMLRPYVSNIVRIEFHEVTKKAIIDAITNPRAISLSMVGAQLVRRIEDRWIGFGLSQIVQEKFGRRTLSAGRVQTPVLGWIIERYDESRRDKVYSVTMTLSNGVKVRLNIPPDKEELIKALKAMHRNKSTDVEVKVRVTKVGEEEEELNPAPPYTTDALLRDSANILGLSVEQTMAIAQELFESGLITYHRTDSTRVSTVGIGIAKEYISERVGADYFVGRAWGGKEIGAHECIRPTRPIDSDDLRNLINTGLLQLAIRVTANHLKVYDLIFRRFMASQMRSARVLKEKLRISIYLNGANVHEEEVERVSKILEPGFTKVWGYIEGREYQELMPGEYGITSIDYIKKVSRTPPLREGDIIAMMKERGIGRPSTYAKIVDVILKRRYALVVGRRTRYVVPTNLGRQVYKFLTEENKEFSDLVSEERTRIVERHMDDVEVGERDYMDVLNELFNEAVSKGILKENVIT
(480) Reverse gyrase [Caldicellulosiruptor owensensis OL]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEKCLEDDHLTENVFELLKGRGLLKDYQIYWNFHQSYKMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFSALHGKKSALVFPTISLAQQSFEKLNQFKSKIKNADAIRILLFNSSMTKSEKEEFEQRFLSQDFEILIVSSQFISKRKDVLSKMFFNLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLKNKNKENGQNTNLNTLKDKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSREKLLEIINILKDGILLFVNTEEEGKEIVKFLAENGVKIGTTWSNFDEEFELFKEGKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPSFRFSVDMDKAPRFVLERVFVEYLEDHPKLKEYFKNVETLQTEKLRQLVLKYISAESYNKIVQEIFSHLKITDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMDESEANFESLMVEVEESRKSRNEGFNVNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEFHDGKFIPYYNSIKRCTKCYTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNTKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFQSYNLSAGRVQSTILGWIVEREKEYAKSERTFTMLKLENGYNLEIEGEEECKRVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRNFGDEGAHEAIRPVKPISPEELKELVYEKYAQGVSQNHIKVYQLIFNRFLSSQMKNPKVLFQKVCFKIADKEIVKDIPVKIEEEGWLHFLSMQIYPLFENKDYSVTDRRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSLKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILSELFNDLKNLLEN
(488) Reverse gyrase [Thermococcus gammatolerans EJ3]
6
MKALYREMCPNCGGRISDERLYMRNPCESCLNEPIVVDSYFELVSAVRDALLKANRLKEWERIYRLESESREIEDFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSVYYATKGKKSYIVVPTTPLVIQTIRKVQAIIERTGLDVKLAYYHGNLRKKEKEEMLAKIEGGDYDILITSAQWLARNFDEKLKGRHFDFIFVDDVDAFLKASKNIDRSLLLLGFTEEIIGKAWEIIRLKKQMARYLNGNSEDKNDRLKELNEAIEKLQREIEEFKRKNDIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPSKDVKEHVEELLRKLGKGGLIFVPIDQGLSYAEELVNYLREKGFAVELASSKNKKAVERFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLGEVMDFLDDEDRKTAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENDFHKTVLNVFRELVEFLREVLKKEDVLRRLAEDPFVSLVKEEGKWFIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFTEFKMVPFEELDLEKLLKEIDEDREKVKLVMEGKISSKVKDLVKSALMIVESPNKARTIANFFGKPSKTRIGELVAYEVSVGDKMLTILASGGHMFDLVTNEGYHGVLIEREEDMFKFIPIYDTIKRCRDCGYQFVDWEERGVCPRCGSRNVHDALENVKAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRVEFHEVTRPAIMKAIREARDVNEARVEAQMVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTVELGKDGKDVEPPEYVTVEEVQLEERELNPSPPYTTDAMLRDASTFLKLSAPETMRLAQDLFELGLITYHRSDSTHVSSTGIEIAREYITSELGEEYFKPRPWGEEGTHEAIRPTRPIDTGRLMQLIRDGVIQLPRNLTRNHYRLYDMIFRRFMTSQMVPAKVLYEKAVINAGVGKVELEGYVEILKDGWTKLRSPPMRQLPKLEQGAKLKVVESKKWKAPKVSLYTQGDIIALMKERGIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTEKGIKVYHYLVSKYRELVSEEKTRELEEKMDLIEEGKLNYLDVLNELYREITCEIKKEGCS
(510) Reverse gyrase [Pyrobaculum sp. 1860]
6
MDIPLVVYLHSCPNCGGPITSDRLALGLPCRECLPEGSKAASIREVVAALRRRRALRGLAWVDAYLRSYEEFSAFFKEVVGFEMWGAQRLWARRLVRGKSFAIMAPTGSGKTTFILVATLYLAGGGRRALLIFPTSALAHQAHKKLTAFAERAGRRVKALAYHSLLTEQERREVLEALERGDFDVLVTTSAFLPRRFDLLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDSVLNAALEVINLAKQMRKAEVAGDLKEVERLDQQIASLRARLREEVGKLKLGVFVASGALAKARRTVRLLLFREILGFDVGGRAEGLRNVVDLYAEAGGDLAGQVVELLKRLGPGGIVYVQDRELGETIAERAREAGIAVETFFRPRRGVLERFERGELAALVGLASSRSALVRGIDLPHVIRYVVFAGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLSGDLRYRADRLIGQLKRLAPYTLSVQEALRKAAEGGELSSFDRHSVEVVKSAVEFVGDLLRREEIRRTVETSTEVKLAYINGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVLVDDAKVFHALRRELKLRFDEAEFRRLDEVDLGKVLEEVDRDRRAIRDIIEGRAAPAATGVELMKTILMIVESPTKARTIANFFGRPSLIIADGVPIYEVSTGDAVLMVTASLGHIYELPTSLARIEQRQREVLAKWFGDFKHDGYNGEDYAVIVTKSGFVPVYNKIWRCRGGVYVDDVDIPQNCKPLDVLESIRNIAVEVDTVLIGTDPDSEGEKIAFDLYMGLRPYVSDIRRIEFHEVTRRAILNALASPRGVSFPLVKGQIVRRVEDRWIGFGLSKVLQERFGNPNLSAGRVQTPVLGWVVKTYEESLRNRMYNVDLQLDDVDLRLQIPRDVLDVLRKKKRLAVKLLGRESRVVNPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGVAIAREYIVKKFGEGAFKPRTWGEEGEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQPTRSHYQLYDLVFRRFVASQMEPSVARVAKYELEVDGHVLTLERVVDIERQGFQVVYQVTPVEPELPTGTIDVVVKRYRVIRRVLSQADVLALMRQRGIGRPSTYARILQVLAKRYYVYVTGRSKIMVPTKRGIEVYHYLENTFSKLVDEERTRLIEQLMDAIEAGKAVYEEVLQELYNEFKINVLPSLSKT
(523) Reverse gyrase [Hyperthermus butylicus DSM 5456]
6
MKNYGGGAAARGVYLYSCPNCGGPVGDDRLSLGLPCPKCLPERTPAESVLDVAEALEKLGRLRRGSELEYYARVEREAREAEALFEKATGSRLWSAQRTWVKRVLKGKSFAAIAPTGVGKTTFGVLMAVYFAWRGEKSYIVVPTTPLVRMVEEKALKLADAAGVPARIIALHGRLPQKVKKELTMRVEEGDFDILITTSQYMIRNAEWLAGLRKRWGKGFRFVFVDDVDAVLKSGKSVDAVLRVVGFTPEEVELGWKLLQLQRQLVVASRRAQEQFLKELARLRQQARRKGKRLSAEEVRRLRRRIFEERLGRLYEELRRVEERLAEARRRAAVLVVSSATGRPRGSRVRLFQALLGFQAGSAGEAIRNIVDAYTYPGPEGIEAKVLELVKRLGDGGLVYVPLDKGAEYAERLAEYLREHGIAAEAFTSRNQAALDRFRAGETKVLVGVAVYYGVAVRGLDLPERIRYAVFAGVPRLKFSARFEDPHPVSILRALAVLAEHAPRDVADRAQALLGRLRAIVRRLSQAALAKIAEELRSETPASEYTRAFVEALEWLRGVLRREDVWEALEAADDIAVVREDGRAYILVPDVATYIQASGRTSRLFAGGITRGLSVVVVDDERLLNGLMRRTRWLVEAEWKRFEELDLPRLLREIDEDRERVRAIIEGRVKPEFMELVKTALLIVESPNKARTIASFFGRPSARQIGPLRVYEVSTGDYVLLVAASGGHVYDLVKPSTPKETVSPDWLLDQLSGSVEGYNWDTARNIHGVLAAEGGERRFLPVYAPLARCLACGHQWTISPEDYNPAEGRGELRCPICGSPLVKSSWDIVEALRDIATEVDVVLVGTDPDTEGEKIGWDIASLIRPAARSIVRIEFHEITRKAIVEALHSLRDFDQRLVEAQIVRRVEDRWIGFTLSPILWTKFWPWYCSWRLKRRLVQGRRMKNLQTALNAMERLASLAEECRRPNYNLSAGRVQTPVLGWIVEHTIGSKYLRIPLYRLQLEHNGSRLEVDVRGDEVSEEIRRALEETHRRLEEALKSHNVLEALEELEKLRRSKRRVILAVNQALREGGAVKARVSKVEEWEEELKPLPPFTTDAMLAEAAARLGIPAPEAMRLAQDLFELGLITYHRTDSTRVSDAGIAVARDYLRYRYGEEKLSEVFQPRRWGTGGAHEAIRPTRPIDAETLRRLVEEGALQLARPLTSRHYRLYDLIFRRFMASQMKPARVRKQKAVVELEFSIPGEKPVRIVREVEKTVEILEPGWLDIYPVVRTEQRLVEGDYRMAGISTRVWSPVQLLTQADVVRMMKERGIGRPSTYAKIIDTLQRRAYVVTSPRRGTMIATSRGIGVYDFLMKRFGSLVSEETTRKLQEIMDRIEEGLANYEDVLSQVLEELRGALEKPESGLTGDEARKLLPV
(544) Reverse gyrase [Pyrococcus horikoshii OT3]
6
MKAIYRGMCPNCRGAITDERLSNKNPCEGCLSEPILSEDYNELIVAVRNALKLRGTLKDWEELYRLNKEVSEIEELFEKSTGFKFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYFATKGKKSYIVVPTTPLVIQTVKKIESMLEKANVSVRLVYYHGNLRKKEKEEALEKIRNGDFDILITSSQFLATRFKELLKDKKFDLIFVDDVDAFLKASKNIDRSLIMLGFSEEIIGRAWEVIKLKKQLAKLLQNEKKNEEEIEKLNKEIEKIEDEIEEYKRRNKIGILIVASATGSAKGDRIKLYRELLGFEVGSGRSVLRNIVDTYLLPEKPIEEHVVELLRKLGKGGLIFVPIDKGIEYAEELTDYLKSQGFKVELVSAKNKKGLELFEKGEIDYLVGVATYYGTLVRGLDLPHLIRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEEKKSEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFHNHVLEVFKQSVEFLREVLKDEEVIKKIAENPFLSLKEIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFDIKKFEEVNLKEVLKEIDRDREKVKLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRKIGDLTAYEVSIGDKMLTILASGGHMFDLVTNEGYHGVLILKNNGKPYFVPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLAPYAPNIKRIEFHEVTRPAILRAIREARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGIILENGINVTIENAKGEVREVEVKDVIIEEKDVNPLPPYTTDTMLQDASRFLGFSATKTMQLAQDLFEAGLCVTPDTLVSLSDGRIIEIREAVENSEESLLGINGLKPKEAKALKFWEIDWDGPIKVIKLKNGHEIKATPDHGLLVMRDGKIGWVSAKNIREGDYVAFIYNLGHRGGKKYTLPQLLKELGISEYENSSSQELNNREQEMDSKQISIELDERFWYIFGVILGKGTLKGDKVVIFQKDVKPVIEEALPFVRIFESADHIGFSHLILAEVFRRLGVGEGKLHSLVFGLREEYINAMIAGYFDASGTFLRRAVLTSKRGDILRMLSVYLYQIGIVNNLRRDEHAGVWELIISDLEKFREKIYPYLRIKKSQFDKVYSISKNEGDFLPVASIFRKLKFRDGFKNRILDEEIPRDEVAKVLEYAEDSPEKEFLNSLVEARVTWVRVEKIEERHYTGKLYDFTTTTENFISNGIVSHNCTYHRTDSIHVSNTGIEVAKEYITQEIGEEYFTPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITIPKNLTRDHFRLYDLIFRRFMASQMKPAKILYEKAIISTPFKDVEVEGYIDVLYDGWSKIKSLPLRQIPKLEKGQRLRVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLITKYKDLVSEERTRQLEKIMDMVEEAKADYQDVLNELYEEIKRYVR
(548) Reverse gyrase [Fervidobacterium nodosum Rt17-B1]
6
MIEAIFKNLCPNCGGDITSERLLNGLLCEKCLPQQVSKEFLCEHIKEEKYDLCSLKERYNDWEKVFRKFIGFDPWELQKFWARKLLLGRSFALLAPTGIGKTSWGLATALYFSKKGKRSYIILPTKLLILQSYEKLKDKVKESDLLVFGLDESNKEREEKKKRLANGDFKILITSSMFLYKNVDLIPKDFAFIFVDDVDSFLKTAKNIDKALYLLGFDEKDISFTMNYIKMKRTQANEEKVKAMQEEVRKIASKAKGVMVVASATSDPKSERIRLFKELLSFDVGRPIFYLRNVEDVYEEVENLDDALVRTVKRLGKGGLVFLSSDFGKERVDYIKNLLESNGIKTETYENLSPEVLEKYRKGEIEVLIGISSYRNPLARGLDMPEVIRYAVFYGVPKIVVNLDIEGNVKHLLLALSSIRPLIARDKDLEEKVSLVDKWMKALKKFSSMPNPPVDKVNELKNEIKNFILSKEIHEKISNSDEVVLRQEDEKWILVVSDITGYLQASGRTSRLYVGGISKGLSYILVDDKKVLNNLLKKSRWWFSTDITFKEARSINIDEILRQIDEDREKVRRKEGRRDDFLKPVLVIVESPHKAWTIANFFGKPISRNVNGQELYEVITEDKYLVITASFGHVLDLNKEIGYFGVIEKEKFIPVYEPIDKKERMIEGIRDASKEFDMILVATDPDTEGEKISWDLKNLCTPFVKEIRRMEFHEITKKAILNALKESRNVNENLVKAQVVRRISDRWVGFELSQLIQKVFSKSSLSAGRVQTPVLGWVIERAKENRKKIHIVSVKRYGLDIKFEFEDKQKAQKFYNGLKYIQINKSSEKIQEKSPLPPYTTDALLKDASEKYKISVSRTMEILQELFERGFITYHRTDSTRVSDVGISVAKSYIAEQFGEEYFKGRTWGEGGAHECIRPTRVLDVEDIKSMIYSGELEDFTPDHLKIYDLIFKRFISSQMRNVVVKSCDITVKAFDKEQTFEIYEEIIQEGYNKIFPIKLTKIPTGEVVVVNYKSFYSVPKVPLFTQGTLVEEMKKRGLGRPSTYATIVSRLLERGYVVEKEGYLIPTPLGEKVYKFLNSSPEKFKFVREDFTRELEQLMDKVELGEEDYQKILKNLKMEIERI
(550) Reverse gyrase [Thermotoga sp. EMP]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEKDYQATLRLLYEEIKSLMEEG
(561) Reverse gyrase [Methanocaldococcus sp. FS406-22]
6
MIPMIYKEMCPNCNGEITSERLAIGVCEKCLKEKNVFEKLKLCEKLREEKTLKELKSYCIIWNEFKEFEEFAKSLGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGILMSLFLAKKGKRCYIILPTTLLVKQTYEKMLSLVEKNNLNIKVVAYHSELSTKEKKEAKERIENNDYDVLITTSNFLTKNMPNCRFDFVFVDDVDALLKASKNIDRTLKLLGFDEEIINEAYKIIYLIKIGKIEDAMKKREILKEKVAKIKHGCLIIASATGKSYGDRVKLYRELLDFEIGFGMNKLRDVVDIYDEEFSKEKILEYIKLFGSGGIVFVSIDYGVEKAQEIEKYLLDNNIKAKLIHSKDKKGFDDFREGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRLKEYINSLKEKGELKEDIDIEGKTEEEIRQIITEKLKIKNFSLRKEDDEYLLLIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDEKEIFEALKKYMLFMYESEFKRIDEINLEELIKKIDEDREKIKVGRAKGKVPDLLKSVLMVVESPNKARTIANFFGKPSVRKINNRNVYEVCIGDLNLIITASGGHVFDLVTKEGFYGVKIEDNLYIPIYTSIKKVNGEQFTDQKDLEELIRQLMEKGEKVNAMDAKENVEIIREIADEVDAIFIATDIDTEGEKIGYDIAINALPFNKNIYRVGFNEITKRAILKAVESFKKGDKLELDENKVRGQIVRRIEDRWIGFRLSQKLWEVFDKNYLSAGRVQTPVLGWIIERYNEHKIKVPYLSLKLENDIYIGKIWEDEFDKDEVEVEVKVYEKEIPPLPPFTTDTLLEEATKRFGLSTDEVMSIAQELFELGLTSYHRTSSTRVSLDGMRVAREYLKLNNMEDYLKNREYFMEGAHECIRPTKPMDTEELIEFLKENNIKLTKNHIKVYDLIFRRFIASQMKEAVVEYEEIYIKDLDEKVEGYIDIKFDGWSRIYNLKLKKLPRIEKSTLKVLDKKLRKIPKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSRDKNKLIPTKLGIDVYNYLISNYPHLISEERTRELEEIMDKIENGEVDYLEVLKALHEEILSIK
(575) Reverse gyrase [Metallosphaera cuprina Ar-4]
6
MNVSDDIPNIVYIQSCPNCGSNITSLRLVQGLTCENCLADGKIKINELSELISILEEQNKIRLLQNEKNILNEEKNVVQLFRKVVGTGPIGPQRSWIIRALRGESFAIVAPPGLGKTTFGIIMSLYFASKSQKSLMMFPTKTLVSQVVQKIQEMSKLLDQPPRVLYYSSGITRSKKAEFNKSLNERDFDVLISTSRYVMENLDELNKIKYRYLFIDDVDAVLKSSKSSITILKLMGFNDDNIGKARELLRLSRDDKSSFEEIRKIRKKFMGERITIFSSATITKSNPVFTSLVGFKPGSATIYLRNVIDSFVVEENPVIQVNQIVNKLGPGGLIFVPIDRGLKYAHEIEKGIEGLNVSVLSSNSTKKLEEFENGSLDILIGVATHYGLLVRGIDIPWRVRYTLFAGIPKFRFKLGETMHPLAMLRILTILSVILKDPNVTNTLKIVKYKLRKISTAALAMLAKSVKEGDLEDRNLIKAYEIVNYYLKQKNVIEQISRFGDVSVNGDYISMPDYLTYIQASGRASRLYGGHLTTGLSVLLVDDTTLFELLKKRLSFILENLSWSPFDIENETVGGIGLKDIIKKIDSERSEIMRKREMGTISQSLGRIKSVLLIVESPNKAKTISNFFSRPSIREFEGLRVYETVMGDKILMITASEGHVYDLTTKEIGIYGVEVHSGDDSHIDAIPFYNTIKKCENGHQFTEYGEGCICPICGSKNIRDKQRSISALRELAMEVDEVLIGSDPDVEGEKIAWDLYLNLRPFNNRIYRAEFHEITRRAITESINSPRNFSVPMLRSQLVRRIEDRWIGFKLTSKLKEEFWRKYCTEFTSRNDCEAGNRNLSAGRVQTPVLGWIKNRYEEYKSTKKKVYVARFNGFSVLVPVQPGIRKNTKVKIIIEDLQRKQETIGPFPAYTTDTYLADASTFYLIPTQESMRVAQDLFESGLITYHRTDSTRISNVGINVAETFLKDMIGEKYKEIFVPRSWGEGGAHEAIRPTRPLNAEQLRVMIEQGEIEPSKRLTFNHYRLYDMIFRRFLSSQLVPLVVEKEVVKISCKKGETTLSLDSNVVEQVVKVSLQKDVGLPSDNLYIPFRSVSTSLDKVVRGTLPFELEATLTNSFIKSNSLLFTQGELVSEMKNKGIGRPSTYSSIISTLLRRGYVFESMKSKRLIPTRLGEEVYKFLSYKYGKFVSEDRTKDLLKRMDDIEEGKGDYRQVLKELYNEIKGIR
(596) Reverse gyrase [Nautilia profundicola AmH]
6
MLHIIYKNECPRCGGDISSVNLNKGMFCDECMKSKKKEWNLENCENLLNYEKYCIADKKVNEFNEFFKFKCGNELNSIQKMWAKRFFLDNSFALLASTGIGKTTFGLLLSAFVKNSYILFPTKLLVAQAAEKYKKWGIEFVAYMGKKSEKELIEKGEYDILITTTQFLYKNRSLIKRNFELIFVDDVDSILKSGKKIADILTLLGIDKNSIEKTYELIKNQKYSEIKSVSKKGNLIVSSATANPKSKKILLFKYLLGFEVSRPNFNLRNIEDLYDENYSWDHSVKWINELGRGGLLFLPGNETKDTLYEYIDFLNTKNIKAYSYEDFEKHLEEFKEGKCFFVGFASYKNPLARGIDLPEYIKYTLFVGVPKIEFNLKDENFRAFYFIMLSLLPYLVKNNLSQKEVSEIQNDLNYLKKYIYLSKINVNTQQKIADILIRFKNTVKKYEDIIKTAENISFDGEKFIIADVTGYIQASGRSSRFYKGHLTKGLSLLLVDNKKAFYSLKKKLKWFGEIEFKNVEDVDIKKVLTEIEKSRTENVKTEFKTSFVIVESPTKAKTISSFFGNPSKRIINNVAVYEVLSQDRVLIIAASIGHDFDLVKDEGVWGVKDLIPIFHVLENKDKILQTLNINANEVEEVYAATDPDREGEKIAFDLTMINKPYNMNIKRIEFHEITKQAFEEALSIPREIDLNLVKSQLFRRITDRWVGFKISLYLQRLLNNTHLSAGRVQTPVLKWICERTGLLKEKIYVVIIRFNNVSIDFEFDTKQEANEFFNSLKESVYIKKLSSNTEVMFEKPFNTPDLLKEASNKLRFSPQKTMQLAQELFEKGFITYHRTDSYRISDTGKAIAKTYILENFSKDYLKFRNFESKGAHEAIRATTSMDADELRSYMLERNILLSEEHLRLYDLIFRKFIASQMKEAKVLKEKFLILLKEKSFITEIVENGYNLIYPINIYIISEGENKIVKELRQKPKAAPYTYAEVIEEMRSKGIGRPSTYAIIIEKLLKRKYITDKNGYLFATKLGFRIIKEVYKSDFKDFVSEEFTAELENIMDKIEEGKTEYEKELKKLFSLLF
(597) Reverse gyrase [Ignisphaera aggregans DSM 17230]
6
MSGINIVFDLGGKGDEELLKIPRGIYLGLCINCGGPIEDNRIIYRNACSKCMNSKDLVEVRDLEELAKHVTSLNPNGRLNYILTLNKFVKEFEEFFQKSIGSKPWSLEISWALRVAQHQSFAMIAPTGVGKTTFGLVMTLFLSYKYGKKVYIIVPTTVLVEEYEKRLWQFSEKLGITLKIIAASSKIHGKRKIELEESIASGSFDILITTSAFLQRNFNDVFKKMLSNNIKMDLIFVDDVDAIIKGSKAIDMVLQLLGFSEEDISNGYKMIDLRRRLLQCENARESSRCYIDGKPIDVIYEELQKKVLEKRERCGILIVASATGRARGKRIKLFRELLGFSIGTAIEVNRNVVDAYIPIDNPAEIIDRLVSIIKILGSGGLIYVPLDLGQEYAVKLATELNSRGIRAGVVISGKSEDLKKFIENELDVVVGVATYYGLLVRGIDIPERIRYAIFVGVPRHKISLTRIEYYPQTLLRLLSVLVDVVEDQMKDRVLRNIAYLRRILRRISPNRIFDIVERLKKGEKVEDELAGIITNAYKLVNELLSDSKIIDRLKKHERVSIIEEEGQLYILIPDAPTYIQASGRTSRLFMGGITRGLSIIFVDDTRLLRGLEERIRVYIDDFRFQSFNEINLEEILKQIDEDRRIVNLIKRGLLEEVIHIPKFSFSRSILFIVESPNKARTIASFFGRPTIREIDGLRVYEVDIGNAHLLIASSGGHVFDIVEEELSENNIYGVQRTVENGKQLFLPIYGYLKRCSVCGAQFVKGTVCPICGSTRIRSSEKIINALQKIALEVDEVIIATDPDSEGEKIGYDMAIALAPYAKIIRRAEFHEVTRKAILSSLYNPRGLKLSLIEAQIVRRIEDRWLGFALSDYVTKRFKELKLESREGRLSAGRVQTPVLGRVIEIYINRLRTQRKYKIFSIGNISLEIPVEDLKKIFGDELKRISKERVEIVLKLLSHEIVNLNPMPPFTTDELIVEAQRQLGIDAVETMRIAQDLFELGFITYHRTDSTRISSTGISIAHEYLLNKFGDLGKELFVPRTWGEGGAHEAIRPTRAMDVDMIQEIIAEQLIELPIRLTNRHLRIYDIIFRRFIASQMKSAKVERNRFEAILKIDGIEVAKQHIEIISNIVEPGYTLIYMPFKTVFLPHGSIALKPLHIKTAILSDVKLPTQGDLVKWMKDVGIGRPSTYAKIVEILLRRGYTFRHRKGSVLIPSITGIIIYNILAGTMLPSIEVDEEEFINILQKHPSIRKYNPEALRQTLAEILRNLSIGIRNMVSVERTRMLYNKMQEIEEGRLSYINVLSELFREMCSNVINMISSEAIEICKS
(608) Reverse gyrase [Sulfolobus islandicus Y.N.15.51]
6
MTSIDKVPPSIYTRSCPNCGGNVSSQRLFNGSACESCLKEDKEFNNLSDLINILSENNTLKNLNQLYNILEEYKEVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYNATRNRKSIIIFPTRTLISQTVDKLAKFSESYSYSPRILYNKQSSTQTENVLEQLKSGDFDIFVSTSRYVIQNLSELSNVKFDFIFVDDVDVALKSGKSAKAILRLVGFTDEDIQTTMKLLRENIGDEEKFGKIQEIRENKLKDKIVIFSSATISRGNPTLSSLMGFRPGSSVIYLRNIYDSYIDLTQTCKERDVDECTLGTVIRVLKRLNDGTLIFVPIDKGVQYAEYLASNLRDHGINAESVASSSISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIGEYMHPLALTRLLNLVYLVKNDDKIRGLLSYIRKRLRRISPAALAMLAKDIREGKIDDERLKEAYSLVNEYLKDTEFLKKISAVGDLVIEGDYILMPDYLTYIQASGRTSRLYGANLTTGLSVLLIDNLRLFELLNKKLNLILDEVKWYPLDIDADRLGQVSLSDIVTKITEERENLSKMKKEGRVESSAINVKTTLFIVESPNKAKTISNFFSRPSTRSYGKLRVYETVLGDRILIVAASGGHIYDLITEDDNERYDGNYVYGVLVKDNKFVPIYSTIKKCEKGHQIVKDLSENKCPICGSKIVADKTEVVDILRKLALEADEVLIGTDPDTEGEKISWDIYLAIRPFNSNIKRAEFHEVTRRAILNAIKNPREFNDNLVKSQIVRRIEDRWIGFKLSRKLQTEFWEQHCKSISKENTECKENRNLSAGRVQTPVLDWIVNRYQKYNENKKKYLIIESQDKSVFPFSILASKKNGLSKKTQLFIQIVDINTKEEDFGPLPPYTTDTLLTDAANLLRIPASETMRIAQDLFELGLITYHRTDSTRISNVGISVAESYLKSKQVDISKVFRPRSWGEGGAHEAIRPTKPLDETMLKASIEQGDLELSKQLTFNHFRVYNLIFRRFITSQLPPLIVTKQIVKIKAYTDDNTELDLDEGKKEFVIGYRLKEGDEFRQVLQEAIYTTFKPYQPIDEKMKGKELIGKVTSTLNKSDVQLYTEGELISEMKSKQIGRPSTYAVIISTLKKRRYIIESKNLKKIIPTKLGMAVKEYLMEKYKQVVSEKRTVKLLEKMNEVEEGKVDYLVLLKELYNEIQTIS
(626) Reverse gyrase [Thermotoga maritima MSB8]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(627) Reverse gyrase [Thermotoga maritima MSB8]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(632) Reverse gyrase [Pyrobaculum calidifontis JCM 11548]
6
MDIPLVVYLHSCPNCGGPVTSDRLAGGLPCRECLPEVVKAGGIADVVRALRRRRALKGLAWVDEYLRRYEEFSSLFKAAVGFEMWGAQRLWARRFVRGRSFAIVAPTGSGKTTFILVATLYAAREGKRALLIFPTSALARQVHQRLLSYAEKAGVSVRAVAYHSLLTEKEKKEALGAVEGGDFDVLIVTSAFLPRYFDLLKRFKFDFVAADDVDSILRATSKNIDRILRLLGVSDEVLKLALDVINAVKELRKAEIAGDLKEVERLDAEVTALRAKLQEEARRLKLGIFVASGALARARRTTRLLLFREILGFDVGGRAEGLRNVVDVYVEQGKDVVGQVVELLKRLGPGGIVYVQDRELGLAIVERAVGESLAVEHFLRPRRGVLERFERGELAALVGLASARSALVRGIDLPHVIRYVVFVGVPKYKFRVRLEEFSIPAYLTFFYNVRAVLSGELRYKVDRAIGQLKRLAPYALSVQEALKKAAEGQELSSFEKHAVDVAKGAVELANSILSDEELRRAIDSSTEVRLAYIGGELYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVVDDWKVFTALQRELKLRFDEAEFKRLDEVDLSAVLAEVDRDRRTIREIMEGKAVVTGGRELMRTLLMVVESPTKARTIANFFGRPSMLLVDGVPVYEVSTGDAVLMVTASLGHIYELPTSLDRISKEEREVLRRWFGDFRRGDYDGGEYAVLATEGGFVPVYNKIWRCRGAVYVDDVDVPPDCRPLDVLAAIRNLAVEVDAVLIGTDPDSEGEKIAFDLYLGLRPYVADIRRVEFHEVTRRAIISALANPRGIDYSRVKAQIIRRIEDRWIGFGLSKILQREFGSPNLSAGRVQTPVLGWVVTTYEESLRQRMYNVELQLDDVDLRLQLPQEALKALRERRRVAIRKAGAETRVVNPPPPYTTDELLRDAVNRLGLSADYAMRIAQDLFESGLITYHRTDSTRVSAAGIAVAREYITKRFGEGAFRPRTWGEEAEGAHEAIRPTRPIDVEELRGLVNAGVLQLAIRLTRSHYQLYDLVFRRFMASQMEPSEVEVERYEVEIDGYVAQVERVVDIKRQGFQVMYQVTAVEPGLPTGTIEVTVKRYRVIRRILSEADVLALMRQRGIGRPSTYARILQVLAKRYYVYVAGRRRLMVPTKRGIEVYHYLEQKFGKLVSEDRTRLIEQHMDAVEQGKAKFEEVLGELFDEFKTEVLPNLSGASPKS
(647) Reverse gyrase [Dictyoglomus thermophilum H-6-12]
6
MIEAIFKGLCPNCGGDITAERLLAGLLCEKCLPEKVPQEALCNHIKEQDYDLCTLRKRYSEWEKIFRNFVGFEPWELQKFWAKKLLLGRSFALLAPTGIGKTSWGLATSLYFAEKGKKSYIILPTRLLILQSYEKLKGKIREKDLLVFGLDENKKEKEEKRERLQEGDFKILITSSMFLYKNVDAIPRDFAFIFVDDVDSFLKTAKNIDKALYLLGFSEEDINFTMSYIRMRRNGGDQENIKEVQEKVREIAKKARGVMVVSSATSNPKSERIRLFKELLSFDVGRPIFYLRNVEDVYEETNDLNKTLVERVKRFGKGGLVFLSSDFGKEYVDDIKNLLISEGITAESYDNLTPEVLEKYQKGEISVLIGISSYRNPLARGLDLPEVIRYAIFYGVPKIVVNLDIEGNVRHLLVALASIRPLIARDKNLEKHIANVDRWMKNLKKYSAVLNPPKDKVDELRNTIKAFILSPEIYEKIKSADDIAIREENGKWILVVSDITGYLQASGRTSRLYVGGISKGLSYILVDDRKVFNNLVRKSRWWFSTDIVFKEASTVDIDDIFRQIDEDRERIRRKEGRRDDFLKPVLVIVESPHKAWTIANFFGRPISRNVNGQELFEVITEDKYLVITASFGHILDLNKEIGYFGVIENGKFVPVYEPIEEKERIISGIRDASKEFDMILVATDPDTEGEKISWDLKNLCAPFTKEIRRMEFHEVTKKAILNSLKESRDVDENLVKAQVVRRISDRWVGFELSQLIQRIFSKNYLSAGRVQTPVLGWVIERAKENKKRIYIVVIRKDGLDLRFDFENKDEAQDFYNNLKYIQIIKDAEKIEEKGPLPPYTTDAILKDASDRFKLSVSRTMEVLQELFERGFITYHRTDSTRVSDTGINLAREYISEQFGEEYFRGRTWGEGGAHECIRPTRVLDVEDIKAMIYSGELEGFTPDHLKIYDLIFKRFIASQMRNVVLKGYEVVVKALDKEQRLELYEEILQDGFDKIFPVKLTRLPDGEIDVINNKFFYSIPKVPLFTQGSLVEEMKKRGLGRPSTYATIVSRLLERGYVIEKNGYLIPTPLGEKVYQYLNSDQERFRFVREDFTRELEELMDKVETGEKDYQAILRSLRNELKKV
(656) Reverse gyrase [Archaeoglobus fulgidus DSM 4304]
6
MIPVVYSNLCPVCGGDLESKEIEKHVCFRKKRSLCLFPEDFLLKEFVEFFRKCVGEPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFLALKGKRCYVIFPTSLLVIQAAETIRKYAEKAGVGTENLIGYYHGRIPKREKENFMQNLRNFKIVITTTQFLSKHYRELGHFDFIFVDDVDAILKASKNVDKLLHLLGFHYDLKTKSWVGEARGCLMVSTATAKKGKKAELFRQLLNFDIGSSRITVRNVEDVAVNDESISTLSSILEKLGTGGIIYARTGEEAEEIYESLKNKFRIGIVTATKKGDYEKFVEGEIDHLIGTAHYYGTLVRGLDLPERIRFAVFVGCPSFRVTIEDIDSLSPQMVKLLAYLYRNVDEIERLLPAVERHIDEVREILKKVMGKERPQAKDVVVREGEVIFPDLRTYIQGSGRTSRLFAGGLTKGASFLLEDDSELLSAFIERAKLYDIEFKSIDEVDFEKLSRELDESRDRYRRRQEFDLIKPALFIVESPTKARQISRFFGKPSVKVLDGAVVYEIPMQKYVLMVTASIGHVVDLITNRGFHGVLVNGRFVPVYASIKRCRDCGYQFTEDRESCPKCGSENVDNSRSRIEALRKLAHDAEFVIVGTDPDTEGEKIAWDLKNLLSGCGAVKRAEFHEVTRRAILEALESLRDVDENLVKAQVVRRIEDRWIGFVLSQKLWERFNNRNLSAGRAQTPVLGWIIDRFQESRERRKIAIVRDFDLVLEHDEEEFDLTIKLVEEREELRTPLPPYTTETMLSDANRILKFSVKQTMQIAQELFENGLITYHRTDSTRVSDVGQRIAKEYLGDDFVGREWGESGAHECIRPTRPLTRDDVQRLIQEGVLVVEGLRWEHFALYDLIFRRFMASQCRPFKVVVKKYSIEFDGKTAEEERIVRAEGRAYELYRAVWVKNELPTGTFRVKAEVKSVPKVLPFTQSEIIQMMKERGIGRPSTYATIVDRLFMRNYVVEKYGRMIPTKLGIDVFRFLVRRYAKFVSEDRTRDLESRMDAIERGELDYLKALEDLYAEIKSID
(695) Reverse gyrase [Metallosphaera cuprina Ar-4]
6
MITSVFHSSCPNCQGPLEDYRALAGLPCTNCLAGDEEPFRDLPQSEKIKAVYNLLVNNNKLAKYWELYYTAEMYDEVINYFNQVVGKEPWSLQKLWLKRLGERENFSLSAPTGMGKTTTLVAYSSYLSKGVLYIVPTKSLQEQICSKIGSISSVSCGYVDRDGISVLTVSYVNKKYESIKDYRPTFIAVDDADAIIKSGKTTDKLVELMGIPKDIYEDAMRLVRLRRSLYLKEDKDEILEKITKLERKIQGFTGAIAQLVVASATLRPKGIKQKALRYISGFDLSNTQTYARNIVDSFSCSSIEEVVQRLGPGGLILVSREYGKEKMREIKDKLTSNNFNVELAISGRKFLQNFSEGKTDILIGSASYYGVAVRGIDEPKRLRYVLFYGVPKSRARAEEAIRNPFTLMKIARLFGVNVPEDEILSLSPAEAQAIKISIIKGQVLPGKLGEVQKKLEDKISEVQEFLKSVNGIVRGETFLISRRGKDVFIEYPDVITYLQGSGRSSRLLNGGLTQGLSVILVDDQILFDLLKKKMNFIIQGFNPVQFESLNVDSITKEIERTRREGGNKIDISTGLMIVESPTKAKTISRLFGFPSRRTIGGVNVYETVIVDGNKVYILDVMATKGHMTDITLEDKGYFGVDVKNDVITPLYSHIYRCVSCKRVVSKEIDVCPYCGSSLINSSLSIVNAMRKLAMEVDEVFIATDPDTEGEKIAFDISVSVSPYNPKVRRIKYHEVTRSGIVEALRTGTSIDINTVYSQIVRRVEDRWIGFELSKLLKSKFNEGNHGAGRVQGPVLGWIVNKTREYKERIGWLLYIKVGNYVYREYHKTKPAIPDGPVQVEVVGERVETLQPPPPFSTDDLLIEAYRWFKVPAERVMRIAQDLFESGLITYHRTDSHHVSGKGIEVAKEYLEKMNFTQDLQPRSWGPEGAHEAIRPTRPLDLESLKKEIGENPMLMSVKFTWSHFAIYDMIFRRFMASQMKEAKGVFKRFAMRMKDRSWEADLLTEMEGGFSRLYKYRTYDIPIGEINPEINLSRGSDVKLLTYADVIKEMKEKNIGRPSTYAKTVQSLLRHGYVVESKKRSVLIATKKGINAYAFLSKFEDLISEKVTADLLAKMDSIVTGKAEPTSILLTVFDNLRSLEALPQSEQEI
(709) Reverse gyrase [Desulfurococcus kamchatkensis 1221n]
6
MINLKTLLENFREFKPHGIYRHACPNCGGPIDDYRLIFKAPCSKCLNEARFKAVIKDLNGEITRFQLLKLYYDKLNKKLKKSGDLKKLMDNERMLNDFEDFFEKAIGFKMWSAQRMWARRILKGLSFSIVAPTGMGKTVFSLIATLYLVSHSRSKNREQRFYLVFPTTPLLLQAERKIKDFSRNLGINVCMDDNWGSNCLRILCIHGQQGKKEKEAALTRLKEGDFDILLTTSKFMHKYYELLKNKNFKLIVMDDVDAVLKSGKAIRRVLNIIGIEDEYIDKALTLIKARSKLAVLSSEEKSKLEKEVESLEKEISTVKQNINTILLVNTATGRPRGIYPKLFKIFMNFEAGSKPEAIRNIVDTYIESIRDIEEKMVELALKLRDGLLIFVPVDRGVEYAEKIASLLKEKGLNAEAFHSGKPAKLLDAFARGEINILVGVATYYGVMVRGIDLPERVKYIMFIGVPRHKFTPELEELSPRDLLRILSVLRDASEGERKEAIDRLIGRLSSRIRRMSPGALMMIREELAKKLRGEPVEETPFLRDAMEAYKIIKEELSKDETWHKISSLGDIGVIREGNKYYMLIPDVATYIQASGRASRLYPGGITRGLSITLVDDKRLLNGLVKRMRWIFEDFNMVSLDQVNLEELTRQIEEERRRVAEVIREGIKTTTQVEPVKTALMIVESPNKAKTIANFFGKPSIRVVKDVLQAYEVTVGNYVLSIVASAGHVYDLITDNPGESMGENLYGVLKIENRFIPVYTDIKKCSNGHQFTDEVIDNTNECPKCRINGKVSHVTRKLDIVKALRELAEEVDVVLIGTDPDAEGEKIAWDLRVLLEPYASDIKRIEFHEVTRKAILNALKNPRDFDLKLVESQIVRRIDDRWLGFSLSEKVQKYAWLKYCSEYLKNKTVKEEKDDSELHEFDCCTQNRNLSAGRVQTPVLEYIVKETEERRKPERWSYRIKIYVEDVGDFVEVTIPYIDAEELGVIKSLNKKKLLPVEIIVIGEDVEEVNPLPPFTTDALLEEASRSLRLSAVRAMEIAQNLFETGLITYHRTDSTRVSDTGISIARQYLEEKYGEKAQFYFKARMWGEGGAHEAIRPTRPIDADRLLELIKEGVLTLSVKFTKDHIRLYDLIFRRFIASQMRPAKLRKLKFKVVIKNREYYSEVYTEAVEKGYLEVYKNIELVQGIRLKPSEPGGRINGKIHEGEVIKPPMLRFHDVVRWMKENGIGRPSTYAKIIQTIIDRRYVIVSGETKALIPVERGRYVLKFLKDHYGDIVSVDTTRRLEDLMEKISRGERDYQEVLEEIYREVKNIVLENKDINDSLEKEYNERCASTT
(711) Reverse gyrase [Ferroglobus placidus DSM 10642]
6
MIPVKYANLCSVCHKDVTWEELEKSYCRFKKLPQCSSFLDKIYKEFEEFFKKIIGEPRSIQKFWAKRVLSFESFAAVAPTGIGKTSFGSAMALFLALKKRKSYIILPTTLLVAQVVENLKKYCEKAGIDCGLNEEKEVTIAYYHGKLKEKDKFFEILEKNSFDILVTTTQFLPRYFEKLNGKIFNFIFVDDVDAVLKASRNVDRILKLLGFRYKNGKWEGKPKGVLMVSTATAKKGQKVKLFRELLNFDVGTSTHAVRNIDDVYVERADVEAVKEILRKMGSGGLIYARSSEEAEELYNSLKDEFKVGLVTAQRKKDFVLFERGEIDYLIGTAYYYGTLVRGLDLPERIRFAVFFKAPVFRVRIEDIDTISPGMVRVIALIFKEDERVKKFIPYLPKITEGTKEFEELKSILKKVIAERKKEVKDFVLREGEVIFPDVRTYIQGSGRTSRLFAGGITKGASFLLEDDEDVLKAFVERARYFDIEFKKIDEVDFESLIREINESREKFRRRAEFKDVIKPTLFIVESPTKARQISRFFGQPSVKVIGDENDVHVVAYEVPTPERILIVTASLGHVTDLITNRAFHGVEVNGIFVPIYASIKRCRDCGYQFTEERENCPKCESSNIDDSKKRIEALRRLAKETGEVIIGTDPDSEGEKIAWDIKNLLSGCATIKRAEFHEVTRRAVTEALANLRDVDENLVKAQIVRRVEDRWIGFILSQKLWEVFKNRNLSAGRAQTPVLGWIIQRAEENKKKKTVAFVKELGLSLEGIAKKELELEIELIEKKEEERTPLPPYTTDSMLRDANAILKMSAKDAMQIAQELFEHGLITYHRTDSTRVSEVGLRIAKEYLGEYFTPREWFAEGAHECIRPTRAIDRDTLQRLISEGIIVVENFTWRHFALYDLIFRRFMASQCKPYKVVVAKYRIKADGKEFEEERIIKAEGRAYELYKSVWVRNELPTGKIKVEAEIRRVPAAPLYTQSDVVALMKERRIGRPSTYATIVDKLFQRNYIIEKGGKLVPTKLGYSVYEYLINNYRSFVSEERTRLLEEMMDKVERGEADYFETLKEMYNEVKQI
(726) Reverse gyrase [Thermococcus sibiricus MM 739]
6
MKAIYKGMCPNCEDKISDERLYKKHPCEICLEDEITSDTYFDLISGIREGLRVRNRIKQWEGVYSLEKKLIEAETLFKNATGFTFWSAQKTWVKRLVKGKSFSIIAPTGMGKSVFGAFMSIYYAKYGKKSYIILPTTPLVTQTIKRVKTFAENTGIDVNLAYYHGNMKKKEKEEMIQKIQTGDFDILITSGQYLARNFDLIKDKKFDFIFVDDVDAFLKASKNIDRSLILLGFNEEMIQKAWEIIKLKKLMAKYLNGNRKDKNEQLKELNKQINIIEKEIREFKDKNKIGVLIIASATGSARGDRIKLYRELLDFEVGSGRSALRNVVDSYLFPENSIEEHVKELLKVLGPGGLIFVPIDQGIAYAERLTNYLQDLGFKVELISARNKKGLQRFENGEVDYLVGVATYYGSIVRGLDIPHLIRYAIFTGIPKFRFSIDLEQPTIYRVLGLMSEVMDFLENEDRKNAEKLHAQIRRLIRNIPQFEILKIEEALAEGLPLEGFSNHVLKVFKEAVQFLRMILKKEDVLKRIEEDPFISLKKEENKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVIIVDNEKVFNGLKRQMRWRFAEFEMRPFHELELEKLLQEIDADREKVKFLLEGKIAEKTKDLVKSALMIVESPNKARTIANFFGHPSKRRIGDLVAYEVSIGELMLTILASGGHMFDLITNDNYHGVLIKEKEGKLYFIPIYDTLKRCRECGHQFVDWESKGVCPRCGSNDVRDVLENVKAMREIAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPTIKRIEFHEVTRPAILKALKEARDINEGRVNAQIVRRIEDRWIGFELSQKLWEVFENPYLSAGRVQTPVLSWIIQRYKEFVESEINFVQLTLENDLSVVLEDVKDGVEEVVVEDVHLEEKEINPLPPYTTDTMLQDASRFLKFSTDYTMRLAQDLFEVGLLTYIRTDSTHVSNVGIEVAKEYITDEIGEEYFVPRKWGEEGTHECIRPTRPIDTGRLMQLLRDGVITLARGLTRDHFRLYDMVFKRFMTSQMKATKVLYEKATIDARIAKAEVEGYVEILYEGWTKLRNLPLKKLPKLEKGQKIKVKETKKWKAPKVPLFSQGDIIALMKEHKIGRPSTYAKIVKTLLDRHYVIETKGRKKLVPTELGTKVYHYLITKYKDLVSEERTKQLEELMGLIEEDKIDYQEVLTELYKEIKKYTA
(746) Reverse gyrase [Staphylothermus marinus F1]
6
MEKILDPIYKNLCPTCRGDVFANSLWDFGVCGKCSDEPGNSINAVTLYHAFKEDLEDFTHFFGKATGDLNPWGAQLTWAKRLLNGENTVIVAPTGMGKTTLLIVYSVYVAKNYNKKVLFLAPTRALAKQIYTRIIEAVKNVCGTCINVLFYDSGLSKKRREEVLLKIKNNEYDILVLTNHFLIRHYDLLDPNHIGLIVIDDVDSLMRSSKNILRLMKLLGFREELIEKAKKRNSIIWKLMLSKSLNKEEDYRKYIEELIEIEAEIDELLRNSSRKQVVIASATGRMKGIYAKVMRDLLRIDVSGITIYGRNITDTYLLISDHVRDTDKILGFIETLGPGALIFISPRHPLKKNLIELVGLLRRKLEEKGYRVAEANPSTIKKFVRGEYDFLIGSSSYYGVSVRGIDAPETIKYVLFIGTPLFTVELGSFLASPNMLIRVSLMLSEVLGDQRFRGVASTIRKLVFPLNNGEIKLLSMLLKNKITINDLGKDSRIVKVYEQILDFYNDIRKSLEELLSKKKVVDMNTITFYHDNNKFYALIPDVMTYIQASGRCSRLYLGKMTHGLSLVVEYDFLSNLVNGLSLKMNMFSRGFGFKDINDIDLYEEKKLLEKTRKELKGLVLTYRNILVIVESPTKAKTIARFFGKPVRRKIGSISVYEIPFVKDSEVIHLNIVATRGHLFDLTTDPSIPNHGVLIENNRISPVYTSIKRCRVCGYQFTYGDRCPRCGSTSFTDSYEVVNVLRKLAQEADEVYIATDPDIEGEKIAYDVYLTIKGFVDRVWRIELHEITLNEFLNALENKRNINLKLVEAEIYRRVLDRVIGFSLSQELWRKYSKNWLGAGRVQTPVLGWIIDHYNKYVSNKCRKIIYITEREGLKFSICIDLKDRDLYEKMRSVEYVTLVLKNSRIETFNPPPPYTTDELLYDASRIGIPSTLTMKIAQELFESGLITYHRTSYHYVSSAGISVASKYLENKNLSKHFHPSHWGNKGAHEAIRPVHPLDREDLEKAVVEGIITPTIPLTWLHYRIYDLIFKRFISSQMNPYKALISEYDVVINNEIVKTLVLPIEVVEEGFNIVMRPKTYGFLKGHDRIDISIKDIKTMITSTKPLCSEGGLVKLMREHGLGRPSTYSKIISNIVRHGYVIRSKKRGFLIPTKTGIEVYDYLSNSFPELVSIDTTRDMEMRIDLIAKGEMRAADEISRVIDRIRRYKLPLSIREVVAEASA
(775) Reverse gyrase [Desulfurococcus mucosus DSM 2162]
6
MLRSVDPLYKGFCPVCGGDVSASELELYGSCKKCSRSSLTPVLRDIVAGDLDDFSGFFSKATNGLSIWGAQRIWSKRLVSGENTVLIAPTGMGKTTLLIVYSLYAARRGKRVVYIAPTRVLLTQVYRRILDAASRIGLADSMILMYDSSAGKKKREEALARIKQGDYRILVVTNSFLSRKTDLLLPVKPDVVIADDVDSIVRSEKNIVRLLRILGYTDEVVELAKKRISLMWRLMVNRAFNSEEKYAEAVKEYIEVDSELEKKLAETPRSQFIVASATGRMKGLMSRVLKELLHVDISGVTIYGRDVTDSYLLIKQGDSGRGVAELIERLGPGGLIYVAPRHPFKKELEEILGNVLKTLSSKGYRIGEATPGNVMKLVKGDLDLLVGSASYYGSSVRGIDAPEAIRYVVFIGSPVFAVKLEALLANPNMMIRALLEIANLAGDPGARGKAADLRRLVYTLSPGELRLVKLALSGKIPEETLSSSERLSSRYPEIKNYYAETLAKVKSILDERHVVEMGSITLVSVDGDYLALIPDVMTYIQASGRTSRLYGLRMTHGLSIVVEYEPLANTVRGLEARLKAINRELGFTDLRGVNLEHELELIASTRRGGGASNGLKYRSILVVVESPTKAKTIARFFGKPVARRLGDVSVYEIPVKLGDEIVHLNIMPTRGHIFDLTTDNEGYYGVLINEGGVSPVYESIKRCRLCGTQFTSGETCPRCGSRVFTDSKTVVAALRKIAGEVDEVYIATDPDIEGEKIAYDVYLAVKYYNEKIWRIELHEITVQEFLKALGSKRGINTLLVEGEVYRRVLDRLIGFKLSQELQSMHGLRFLGAGRVQTPVLGLVIERYRSFLRNRCKRVSFKLGAPLNTVFTILVDKGSELPSKLKDARVLKLVRTRREEVVVSPKPPYTTDELLADAARLGLPAGTAMMIAQQLFEAGLITYHRTDSHYVSNTGISVAVKYMEEKGFSRVARPSHWGSQGTHEAIRPVHPYDVDDLLKAIAEGLVNVVIPLTGLHLRLYDMIFKRFISSQMKPFKSVKSTFAVYYDGLKLGEVELLTRIVEDGFNLFEKVKVHSELDDVESLDVSVEDVVIADSSRIPLYTEGELVSLMKQLGLGRPSTYSKIIENVRRHGYVIASKKRLKLIPTKRGMEVYEYLVSRYPDLVSVETTRRLEESIDRIGKGEVDARTLLTEVCSRLNIWGKPVEGATSISS
(802) Reverse gyrase [Thermococcus onnurineus NA1]
6
MKAVYREMCPNCLGRISDERLCLKNPCNECLDETAHADSYFELITAVRNALQLKGTLKEWERIYELESGVREVEAFFENATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMALWHATKGKKSYIVVPTTPLVIQTVKKIQAIAEKSGVQINLAYYHGNLRKKEKEEMLAKIENDDYQILVTSAQWLARNFDEKLKGRRFDFIFVDDVDAFLKASKNIDRSLLLLGFTEEVINKAWEIIRLKKSMAKYINGRAEDRDERLKELNREIEKLQREIEEFKEKNGVGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLMPTKDIKEHVEELLTRLGKGGIIFTPIDQGLAYAEELVNYLRGKGFRIELVSSKNKKAIERFEKGEADYLIGSATYYGSLVRGLDMPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLTEVMDFLNDEQRREAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIDNSFHNHVLNVFRELVEFLRKVLRDEEVLRKLAEDPFISLKEEGGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFTEFKMTPFEELNLDEILRQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGNRMLTILASGGHMFDLVTNEGYHGVLIEEKDDMLKFIPVYDTIKRCRDCGHQFVDWEEKGICPRCGSTNVRDALENVKAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILRAIEEAREVNEGRVNAQLVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFTESETYFLGLTLENELSVTIELGKDAKEVEPPEEVLVEDVSLEERELNPAPPYTTDAMLKDASTFLKLSASETMRLAQDLFELGLITYHRTDSTHVSNTGIEVAKEYITQEVGEEYFRPRPWGEEGTHEAIRPTRPIDTGRLMQLIRDGIIQLSKNLTRNHYRLYDMIFKRFMTSQMKSAKVLYEKAIIDAKVGKAEIEGYVEVIEDGWTKLRSPPMRQLPRLEKGVSLKVVEAKKWKAPKVPLYTQGDIIALMKERKIGRPSTYAKIVQTLLQRYYVIETRGRKKLVPTDQGIKVYHYLISKYKELVGEEKTRELEEIMDMIEENKTDYQEVLRGLYSEIREYLK
(810) Reverse gyrase [Caldicellulosiruptor lactoaceticus 6A]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEQCLSQEQISKNIFESLKKKGTLKDYQIYWNFQQNFDTFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEAFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFENLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILSELFNDLKNLIEN
(827) Reverse gyrase 1 [Aquifex aeolicus VF5]
6
MIKAIFDTLCPNCGGEISAERLLKGLPCEKCLPEEVNREEVCQKLENGSFKEFCELLSELKDWEDFFKEILGTSPWSLQKSWARKVFLGRSFAMLAPTGVGKTTFGLSMASYLAKQGKKSYIILPTQLLVEQVSERIKTFGVDEDRLIVWGKLSEKKKKELKERIQKGDFDILITTSMFLYKNYEILPKDFSFIFVDDVDSFLKTAKNVDKVLYLLGFSEEDIHKAFELIRLKEKPNKSEEDWEEIKKRSEELREIAKKKKGVLAVSSATGNPRSNRIKLFRELLGFEVGKPSVLLRNIVETYEETQNLKETLLKRVKEFGKGGLVFVSSDYGREAVEEVKKFLESHGVKAVTYEEDLKLFEKGEAQVAIGISSFKNPLARGIDLPHVVRYAIFYGVPKIRVPLKVETSVSHLLWALLSLRPIILKDEKLKSEVKKVDTWIQRLRRYSFLSDDFVEERPDLKDRIENLRKEVQEFLLREDIVEKIKNSEELTLRLGEEGFELVVADVTGYLQASGRTSRMYAGGLTKGLSHVLVDDRRAFKNLEKKVRWFNQDINFKKIEEVDLKEVLREIDEDRKKVREILEGKVKAEQKEHVKPVLVVVESPNKARTIANFFGKPMGRKIGGIDVLEVMVGDLYIMITASLGHVFDLVKDKEFHGVIAKNGEYVPIYEVIEGKENIVKGLRELAQEVDTVLIGTDPDTEGEKIGWDLGALLSPYIPNVERIEFHEVTRKAIKHAVENPRDFNENLVKAQLVRRIADRWVGFEVSRIVQQAFDKHWLSGGRVQIPVLGWIIEREKLYRKKKHVVQITFKENGRWLRLGFEFQDKKEAKEFYENLKEIDVEVLEEREELKNPPPPFTTDTMLKEASDRYRISVPKLMQLAQELFEYGLITYHRTDSTRVSDVGIGVAKEWISEELGKELFYPRVWGEGGAHECIRPTKPLDVEDLRSMMLAGQLQNLTREHLLLYELIFKRFMASQMKPVKVKTKKVKVKALGREQELILTTEILEEGFNKVYPLELQPDLKGSVYVEDKKELKSVPMAYLYTQGSLVEEMKRRGIGRPSTYATIVSKLLERGYVIERHGFLIPTKLGKQVYEFLKSREKIMPFVSEEFTRKLEELMDKVEEGKEDYLQVLDELYKKVNEFEKANV
(845) Reverse gyrase [Methanocaldococcus infernus ME]
6
MPVPMIFKEMCPNCGGEISSERLTIGVCENCLPEDIRLEKLELCKKIEVKNLKNYCKVWREFKEFEDFVKSLGYKLLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGVLISLYLASKGKRCYIILPTTLLVKQTYERITKIIEEKNLKINVVAYHSELKNREKREAKEKIENNEFDILITTSSYLTKNMPKAKFDFIFVDDVDALLKSSKNIDRTLMLLGFSEEHINLASKIVFLIRIGKFEDAMKLREELKEKIKDVKHGCLVIASATGKSYGDRVKLYRELLNFEVGFGMNKLRDVTDLYDDKLSVEEIVRYVKKLGDGGLIFVSMDYGVEKAKEIEERLLEEGVKAKLIHSKDKKGFEDFKEGKLEVLIGVASYYGVLVRGLDMPERVRYSLFYGIPKFKIKLREYVRKLVEEGKLKEEIEIEGKSLEEIENIVREKLKIRNFSLREEDDIYLLLPDVKTYIQASGRTSRMTEFGLTKGLSIVLSDDKKLLEYLSKYMIFMYESEFKHVSEVNLEEIIKEIDEDRERLRREKRKKEVPDLLKSVLMVVESPNKARTIASFFGKPSVRKINNRNIYEVCVGDLNLIITASGGHVFDLVTKEGFYGVKIEDNLYIPIYCSIKKVDGEQFTDQKDIEELIKENVNFMDSKENIEIIREIADEVDAIFIATDIDTEGEKIGYDIALNVMPFNNSIYRVGFNEITKRAILRAVEAFKNKEKLELDENKVKGQVVRRIEDRWIGFRLSQKLWEVFGKNYLSAGRVQTPVLGWIIERYNEHREKVNLLSLRLEEDIYVSKVFDGEFDREEVNIEVKIYERKIEPQPPFTTDTLLEEATKRFNLSVDEVMSIAQDLFELGLCTYHRTSSTRVSLDGMRVAKEYLKLNGLEDYLKNREFFMEGAHECIRPTKPMDTEELIEFIKENNIRLTKNHIKVYDLIFRRFMASQMKEVLVEYEEIYIKELDEKIEGYIEVKFDGWSKLYWLKLKKLPRVEKDKLKVLEKSVRRIPKVPLYDEGEVVKLMKERKIGRPSTYAQIIKKLLDRGYVIKSKDKGKLVPTKLGIEVYNYLITNYPELISEKRTRELEEIMDKIENGEIDYIEVLNELYKEILSIT
(846) Reverse gyrase [Thermococcus barophilus MP]
6
MKAIYREMCPNCEDRISDERLYKKHPCDVCLDREIQAEIYFDLITGIREALKLRRTLKHWENIYKLEKKLREIEDLFEKATGFNFWSAQKTWVKRLIKNKSFSIIAPTGMGKSVFGSFMALYYAKKKKKSYIVLPTTPLVVQTIKRVKTFAERAGIEINLAYYHGGMKKKEKEEMTEKIMSGDFDILITSAQWLARNFDEMLKDKRFDFIFVDDVDAFLKASKNIDRSLILLGFTEEIIQKAWEIIRLKKQMAKFLNGNSPDKQEQLKELNKQINKLEREIRKFKRENKIGVLIVASATGSARGDRIKLYRELLDFEVGSGRSALRNVVDSYLFPEKSIEEHVEELLTKLGKGGLIFVPIDQGISYAEKLTQYLQEKGFKVELVSARNKKGLEKFENEEIDYLVGVATYYGTIVRGLDLPHLIRYAIFTGVPKFRFSLDLEQPTIYRVLGLMSEVMEFLDEEDRREGERLYARLRRLIRNIPQFELMKIEEALAEGLPLEGFHSHVLEVFKQSVEFLRRVLKKEEVLKRIEEDPFVSLKEEEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDNEKVFNGLKRQMRWRFAEFEMKPFEELNLEELLREIDSDREKVRLILAGKISEKTKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDRMLTILASGGHMFDLVTTEGYHGVLIEERDGKLYFIPVYDTIKRCRDCGHQFVDWEERGVCPRCGSRNVRDALENVIAMREIAQEVDEILIGTDPDVEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKALNEARDVNEFRVNAQLVRRIEDRWIGFELSQKLWEVFESRNLSAGRVQTPVLGWVIQRYKEFVESETDFMALTLENGLSVTLEGVKDEVNEIIVEDVQIEEKEINPFPPYTTDTMLQDASRFLGFSAPHTMQLAQDLFELGLITYHRTDSTHVSNTGIEVAKEYISEEIGEEYFAPRKWGEEGAHECIRPTRPIDTGRLMQLLRDGIITLARGLTRDHFRLYDMIFKRFMASQMKAAKVLYEKAVIDARIAKTEIEGYVEIIFDGWTKLRAPPLKQLPRLEKGQKLKVIEVKKWRAPKVSLYTQGDLIALMKERKIGRPSTYAKIVKTLLDRHYVIETKGRKKLVPTELGTKVYHYLISKYKELVSEERTRQLEELMDLVEENKADYQEVLSNMYEEIKQYILK
(848) Reverse gyrase [Desulfurococcus kamchatkensis 1221n]
6
MPGAFNPLYKGFCPVCGGDILSSEVELRGFCSRCANSGLTSILRDIASSGLGDFEEFFRRASNGLSVWGAQKIWAKRLVSGENTVLIAPTGMGKTTLLIIYSLYAARRGKRVVYITPTRTLLTQIHRRLVEAAERTGINGVNLIAYDSSMSKKKREEVLSRIEKGEYSILVATNGFLSRKSELLSRSRPDIVIADDVDSVVRSEKNVLRLLRILGYSDEVIELAKKRISLLWRLMVNKAFNNNDKYAELVKEYIEVDSLIEKTLSSTRHAQFIVASATGRMKGLMGRILKELLHVDISGVTIYGRDVTDAYMLIKPGELHGELVRIIEKLGPGGIIYIAPHHPFKNMLKEELDKAVNILADKGFRIGDATPGNVARLIKGELDILTGSASYYGSSVRGIDAPEAIRYVVFIGSPVFATSLESLLANPGMMIRVLLELVDSNDARNRVLELRRLLYTLTPGEVRLVKLALTGKILEEALQASEKLYSKYQVIKQYYRETLERTRSILDEKGIMDIGTLTLVRAGGDYYALIPDVMTYIQASGRTSRLYGSRMTHGLSIVFEYRALYNTVKGLEARLKGLNKELVFIDLASVDLDSEIKAIESSRRNNDSSPGMSYRSILVVVESPTKAKTIARFFGKPVARKLGDVTVYEIPVKIGGEIIHLNIVPTRGHIFDLTTGEEGYYGVVIADNRVTPVYEYIKKCRLCGTQFTTGDHCPRCGSRLFSDSRTIVAALRKIAGEVDEVYIATDPDIEGEKIAYDVYLAVKYYNEKVWRIELHEITLQEFLKAINNKRGINQRLVEGEIYRRVLDRLVGFKLSQELQGIYGLRFLGAGRVQTPTLGLVIDRYEEYMRNKCKKIRFKLGSPLNIIYSVFMGKNSEVIRELKTAKMLKLVRVGREIVTITPKPPYTTDELLSDAAKLNLHTGIVMSIAQQLFEAGLITYHRTDSHYVSNTGIGIAMKYIEGKKLEDYARPSHWGSPGTHEAIRPVYPYDLDDLLKAVSEGVINTVIPLTGMHLKLYDLIFKRFISSQLKPFKAVKSIYAVYFGEFKLGEIELLTNIVEEGFNVFEKTRVYKELDAVESIEVPVEEISVVDSSKSPLFTEGELVSLMKKLGLGRPSTYSKIIESIKRHGYVFVSKKRLKLIPSKRGIEVYGYLRDRYPELVSIEATRRLEESIDKIINGEVDALVYLTDIGSRLNMFHSINMVNRGDFASTSS
(863) Reverse gyrase [Pyrobaculum aerophilum str. IM2]
6
MEVPLVAYLHSCPNCGGPITSDRLASGLPCRECLPDGAKAGSIKQVITALRKRKALQGLAWVEAYLRGYEEFAEFFKRIVGFEMWGAQRLWARRFVRGKSFAIVAPTGSGKTTFILIATLYSAKQGKRALLIFPTSALAHQAYKKLLTFAERGGVSLKALAYHSLLTEREKKEALEALERGDFDVLVTTSAFLPKRFELLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDAVLNTALEVINLTKQLRKAEVAGDLKEVERLDQEMAKLRAKLREEVQRLKLGVFVASGALAKARRTVRLLLFREILGFDVGGRAEGLRNVVDLYVEASDNVIEQTLALVKRLGPGGIIYVQDRELGEAIVERAREAGLAVEHFFRPRRGVLESFERGELAALVGLASSRSALVRGIDLPHVIRYVIFVGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLAGDARYKADRLIGQLKRLAPYALSVQEALKKASEGAELSSFDRHAVDVVKSAVEFVNSLLQNEEIRKAIETSSEVKLAYIDGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDPKVFHALKRELSLRFDEAEFKHLGEADLDKILADVDRDRKTIRDIMEGRLVPAARGVDLMRTILMVVESPTKARTIANFFGRPSLIISEGIPIYEVSTGDAVLMVTASLGHIYELPTSLNKIDQRQREVLAKWFGDFKHGNYDGENYAVIVKEYGFVPVYNKIWRCRGAVYVDDIDIPPGCKPLDVLEAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVQDIRRVEFHEVTRRAILNALANPRGVNFSLVKAQIVRRVEDRWIGFGLSKILQANFKNPNLSAGRVQTPVLGWIVNTYEESLKNRVYNVELQLNDVDIRLQVPRDVLDVLRKKKRVAIKLVARERRQVNPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGIAIAREYIVRKFGEGVFKPRSWGEAEEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQLTKSHYQLYDIIFRRFMASQMEPSVVEVAKYNVEIDGHVIQLERTVGVAYMGFQTLYQLTPVEPELPTGTLDVVIKRYRVVRRVLSQADVLALMRQRGIGRPSTYAHILQVLAKRYYVYVTGRTKLMIPTKRGREIFRFLKEAFGKLVSEDRTRLIEQYMDAIEVGKARYEEVIAELYDEFRKEVLPHLAS
(887) Reverse gyrase [Thermodesulfobacterium geofontis OPF15]
6
MLFYVAKGCPNCKGIISDERLTKELPCEKCLPEKEKPSLSNFSDICKILYSQNSLKDLKPFCEVEKKIELFKKVFKNLLNTFPSSLQIGWAKRFFLGESFAIVAPTGTGKTTFGLISSLFTPKKALIIVPTKVLVKQTEEKLNQYLAKIKEPLLKNKIILAYTGSNKEKELLEKGKFDIFICTSAFLHRNFELLKNIDFSLIFVDDVDSFLKNSKNVDNLFLLLGFSKKEIELALKRDKEEKDYEDLLKIKEKHKKSIKQLIISSATLKPKTNRVLLFQNLLGFEITRFVSTLRKVIDTYIPVDLNDKKNKDEVFYQLLKVAENLIANLKEGGLIFVEESFGKSYVEVTTDYLRNKGFKVISYLEADEEELLNALKNKKVDVAIGLCHIGNPLVRGIDIPEVLRYALFLGVPKHIFPLSKSKEGFSLSISPQFLQSILISLMPLFDEEEKIIALSHINYLRRYLTLKEEQVMQYEGLYKKILNIKEFIEKKLNDPDFLENLKKSEEVFLEVDDEGNYYVIVGNASSYLQASGRVSRLTTRGLLPGLSIILVDNFKALNSLKKRLRFYLGEEVELKEVDLEKVLILDKEIREERQKLTKEKIDFKNYLLIVESPHKAKTIANFFGKPSVRRIKSVFIYEIPMENNLLSVCASLGHVFDLSRKIGIFGIIKDNNHFYPVFNTIKIDKINKEQFVDEEEIRNRDEIFDKAEIIEVLRTLSFCADQVFIASDPDAEGEKIAYDLYINLKPFQPNIKRLEFHEVTAKALRSALENPQEINIARVKAQLARRVADRWVGFSLSQQLWKVFKKSRLSAGRVQTPVLGWIIERAELAKQYKYRISFSLNGYKLSLEIEDEALAKKILEELPKNLEIKVLRYFEDELSPPPPYTTDTVLEDAFHFFRFSSSYTMQLLQELFELGLITYHRTDSTRISETGRYQVAKPYIIQTLGEEYFYPREWFSEGAHEGIRPTRPWDLAEIKLRVAHGLLTFKNPKDSFKLYDIIFRRFMASQTRKTKVLKGTFEFKLPSYSWEEDLILDIKEPGYEYFWTKPQIFKLKESLYPENIQYSKVPKVFLYNQGTLIQEMKKRGLGRPSTYAEIVSTLLQRYYVYELKNGSLVPTPLGKEVYNYLKSNYSEYVSEEFTRELEKFMDEVEEGKRDWEEICFKLLPLLNFLNISFSN
(890) Reverse gyrase [Thermococcus sp. 4557]
6
MKAIYREMCPNCLGRISDERLINKNPCSECLDDTVTADSYFDLITAVRSALKLRGTLKEWERIYSLENGLREVEGFFEKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHATRGKKSYIVVPTTPLVVQTARKIRKIAENAGVEVNLAYYHGNLRKKEKEEMLAKIQNEDYGILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDEVIGKAWEIIRLKKQMSKYLNGRAKDREERLKELNAQIAELQRDIEEFKRENPIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVADTYLKPSKDIKEHVEDLLTMLGRGGIIFTPIDQGLGYAEELADYLRERGFRIELVSSKNRKAIERFENGEADYLIGSATYYGSLVRGLDMPHLIRYAIFTGVPKFRFSIDLERPTIYRALGLLSEVMDFLSDEDRKQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLKDEEVLRKLAEDPFISLKEEDGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLLRQMRWRFTEFKMVPFKELDLDEVLRQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVLVDEKDGMLKFIPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSTNVRDALQNVKAMRELAQEVDEILIATDPDTEGEKIAWDIMNVLSPYTPNIKRIEFHEVTRPAIMRAIEEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWVIERYKEFTESETYFMGLTLENDLRVTIELGKDGKGIEPPEYVTVEDVQLEERELKPSPPYTTDAMLKDASTFLKLSAPEAMRIAQDLFEMGLITYHRTDSTHVSNTGIEIAKEYITQELGEEYFKPRPWGEEGTHEAIRPTRPIDTGRLMQLIRDGILQLPKNLTRNHYRLYDMIFKKFMTSQMKAARIIHERAVIDAGIGKTEVEGYVEVVEDGWTRLRSPPMRQLPMLEKGARLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVQTLLQRYYAIETRGRKKLVPTDQGIKVYHYLISKYKDLVNEEKTRGLEEMMDRIEEGSVDYQEVLNALYRELQGYLGNGKPQ
(909) Reverse gyrase [Methanocaldococcus jannaschii DSM 2661]
6
MIPMIYKEMCPNCNGEITSERLAIGVCEKCLKEENVFEKLKLCEKLREEKTLKNLKDYCIIWNEFKEFEEFVKDLGFELLSIQKMWAKRVLKNKSFSIVVPTGVGKSFFGILMSLFLAKKGKRCYIILPTTLLVKQTYEKISSLTEKNNLNIRVVAYHSELSTKEKKEVKERIENNDYDVLITTSNYLTKNMPKCKFDFVFVDDVDALLKASKNIDRTLKLLGFDEEIINEAYKIIYLIKIGKIEDAMKKREILKKKISKIKHGCLIIASATGKSYGDRVKLYRELLDFEIGFGMNKLRDVVDIYDEEFSKEKILEYIKLFGSGGIVFVSIDYGVEKAQEIEKYLLENNIKAKLIHSKDKKGFDDFREGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRLKEYINSLKEKGELKEDINIEGKTEEEIRQIITEKLKIKNFSLRKEDDEYLLLIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDEKEIFEALKKYMLFMYESEFKRIDEVNLEELIKKIDEDREKIKVGRAKGKVPDLLKSVLMVVESPNKARTIANFFGKPSVRKINNRNVYEVCIGDLNLIITASGGHVFDLVTKEGFYGVKIENNLYIPIYTSIKKVNGEQFTDQKDLEELIKQLMEKGERVNAMDAKENIEIIREIADEVDAIFIATDIDTEGEKIGYDIAINALPFNRNIYRVGFNEITKRAILKAVESFKKGEELSLDENKVKGQVVRRIEDRWIGFRLSQKLWEVFNKNYLSAGRVQTPVLGWIIERYNEHKIKVPYLSLKLENDIYIGKIWEDEFDKDEVEVEVKVYEKEIPPLPPFTTDTLLEEATKRFGLSTDEIMSIAQELFELGLCLTPDTYVVLGDGRIETIEDIVNAKERNVLSLDLDNLSIKIDTAIKFWKLRYNGNLSKITLSNNYELKATPDHCLLVLRDNQLKWIPAKDIKENDYIAMPFNYKVERKPISLLNLLKYLDITDVLIEFDENSTIFEKIAEYIRNNIKTSTKYKYLRNRRVPLKYLIEWNFDLDEIEKEAKYIYKSVAGTKKIPLFKLDERFWYFAGLVLGDGSIQDSKIRIAQTPLKDVKSILDETFPFLHNWISGNQVIISNPIIAEILEKLGMRNGKLNGIIFSLPESYINALIAGYFDTDGCFSLLYDKKAKKHNLRMVLTSKRRDVLEKIGIYLNSIGILNTLHKSREVYSLIISNKSLETFKEKIAKYLKIRKEAFINGYKTYKKEHEERFECDLLPVKEVFKKLTFEKGRKEILKDSKIHIENWYKEKTNNIPREKLKTVLRYANNSEHKEFLEKIVNGDISFVRVKKVENIPYDGYVYDLSIKHNQNFISNGVISHNCTYHRTSSTRVSLDGMRVAREYLKLNNLEDYLKNREYFMEGAHECIRPTKPMNTDELIEFLKENNIKLTKNHIKVYDLIFRRFIASQMKEAVVEYEEIYIKDLDEKVEGYVDIKFDGWSRIYNLKLKKLPRIEKSSLKVLDKKLRKIPKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVVKSKDKNKLIPTKLGIEVYNYLINNYPHLISEERTRELEEIMDKIENGEVDYIEVLKALHEEILSIR
(919) Reverse gyrase [Ignisphaera aggregans DSM 17230]
6
MTLAIYRHGCPYCGSSIYVGEDSWSCENCEMINRFRHGNSYVDVWFKEIRDFIEFFRMATGFSPWSLQTYWIKRLLSGESFAMVAPTGIGKSTLLGVYALYRAYFYRSKIYIITPTREIAKQFYSKISEYLRTISKNFHGADKLRIIFYDSSSKNHKDILKLINENMFDILITSSSFLSRHHVIVDSSKIDIVIADDLDSIMRNSKSVDRVLKILGFDEKIVNLAMELVKLKQSFYVAKLAKSQESVENIRRKIIEMEAILKNEVAKRNTQLVVASATGRSAGMKALILKELLGFDSGAIFEYWRNIVDIYSQIDDKMMIYIKEIIEKMKSGIIFVSSPYKDYIDVIVKKLMDMNIKVAVVKSGNKAVDKFRRGEVDVLIGSSSYYGILVRGLDEPQRIKFVIFIGLPQIMKELWNSLSNIRLLYMIAKCLNEQGIDLSNDIKTLINIIQSSSPAQLILLSKALNGREYPNDLRDKVEELAKIRDRVYEEAKKFLDTNGKLVINNYGILVKLGHRYVILKPDPYTYIQASGRCSRLFNGIKTFGVSIVFENYKELIELMEKKMKRFVDGFRFINLSDADIDEYVLRAESTRSLNFSGDGTIDIRKGISTALIIVESPTKAKTIASMFGKPAKKVYGNVIVYESIIPISRDKVYVSMIVATLGHITDLVTDEGLYGVRVNNDRYIPIYDFITKCRRCGAQIVGIYDECPYCNSIDVQSSNTIYNVLKKLALEVDNIFIATDPDTEGEKIAFDIYNLLYPINKNLFRIEFREITKNAVLEALKNPRRIDIKRVKAQMTRRIIDRWIGFELSMVLQDKFNKPWLGAGRVQSPVLLWVARRYKEYIDSIGYILYCDLYGYKIKIYLGNNVDRNYVEKIMDRISNEGLEVKDVEIIERTIQPPPPFTTDSLLYEASNKYGYSASKIMAIAQSLFEQGLITYHRTDSTRISSLGLSIAREALAKENLLEYYVPRQWNVENNAEDAHEAIRPTNPINADELIELIMRGELGIITRISDDHLKIYDLIYRRFLASQMKPARVLVLRANIGIDKYFTNIEAIIDIIEKGFMSIYPLKIYPDLRNLEKTTFIKPNKIFVKKGSAIGLYRVADLIRMLKEKGIGRPSTYAKAIDNNIRHGYIILSKKVKATIPTKLGKEISEIIEQRYINLVGDKVTYELEREIDLIERGLRDMNYVLNRVRQAIDIIINTEGNNIIQLFSDTETVNISDNRVELISSE
(926) Reverse gyrase [Staphylothermus marinus F1]
6
MVELKHIHGYYRYSCPNCGGEDSDLRLIHKAPCDKCIEEELFYRIRENIGEKSYKEILETYYRMLLKNNKLKKRFEFLYKFEEKLEKFEKFFSEATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYLSKKQIMIQKNRISRKKIYLVFPTTPLLLQAEKKLRKLAEQEKIPVCQEEDSDQTCLNIISIHGRVPKKKREKLLEEIRSGNFDILLSTNMFMHKNYELLLDKKYELIVMDDVDAILRSGKAIRILFYILGLTDQEINEAIEYLKLRQRLALKLSEEERRELEEKLETLEKRIEKYKRKIDTVVIVSSATGKPRGIYPRLFRILLNFEAGSRAEAIRNIVDTYTYSKESLEQTIIRLAKKLGDGGLIFVPIDKGVEYAETIAELLKKHGINAEAFHAKKAVKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFSTRLESPSPIDVLRIFTILRDVLEGEEKRKAEILIGRISLRLRRLSQGALMKLKEDFMKKLQGEEVEEYPLLSLLMEALSMARELLSKPEIWEKLKQKGDVALVQEDGKSYILIPDVATYIQASGRTSRLYPGGITKGLSIVIVDDQRLLNGLIKRMRWLFEEFDMKRLDEVDLDKLMKEINEERRKVKMILEGRIEVEKTLELTKSALLIVESPNKARTIANFFGKPSIRILENGMPVYDVTTGDYVLSIIASIGHVYDLVVDDGLYNYGVRLVGDKFIPVYTDIKRCNKCGYQFTAETNTCPKCGSRDISRKLDIVETLRELANEVDVVFIGTDPDTEGEKIGWDIKVLLEPYAREIKRVEFHEITRKAILNAIRNPRDFDMKLVEAQIVRRVEDRWLGFALSKKVQKYFWPIYCFKVLHPLLNKYVREGKRITDKMPFCCIENRNLSAGRVQTPVLGYIIRRFKEHNDESKFRYLLTIKINDSRLRVDIDRSVLEIIGITSHRNLIGYRVEVREEDRKEEIINPPPPFTTDTLLEEASIRLGLSTTRTMEIAQELFELGLITYHRTDSTRISDAGINVARQYLEEKLGEKAKEVFKPRTWGVGGAHEAIRPTRPIDADRLAELIREGALILARPLTRLHYMVYKLIFNRFIASQMIPAKIVKQVLKIRMNGYEKKVERVIGIIEKGFLEFYQTVNVEEEVKPGTYPVVDVEVLKPPLARYHDVIKWMKTNGIGRPSTYAKIIQTLIDRKYVNVSKRVKALIPTKRGTMVYEEFLDKYYKDVVSVEVTRELEKKMKEVEEGIRDYQEVLHEIFNELKTKIIDNPVVNKELEQKWSKHCGQIESSK
(946) Reverse gyrase [Caldicellulosiruptor kristjanssonii I77R1B]
6
MATGAKYYHSCINCGGINTDIRNENGLPCEQCLSQEQINDIYESLKKMGTLKDYRLYWNFQQNFDMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANAVKILLFNSSMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFLIDMDKAPRFVLERVFVEYLDNHPKLKGYFKSVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWVEENGVDFKNLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLDFLPMQIYPLFENKDYGITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLQELYNDISALVND
(954) Reverse gyrase [Candidatus Korarchaeum cryptofilum OPF8]
6
MIPAAFLGLCPGSEIFKTHERSSCLEEDLRAISEELKDYKKFFESCIGSPPWEAQLMWAKRALARRSFAAIAPTGVGKTVFGLITGSYFAHKGFGKSYMLFPTSLLVDQAHYNLLNYSKCSGKQIRVISYRSGMKGKEEFLSALESGDFDILLTTSQYLSANHELIRKSVNKFSFIFVDDVDSFLKNSKNVDKVLQLMGFDQEDIWNAMRGREVEKRTDSVLVVSTATGRPGQRASLFRSLLGFEVGIMRPELLRNIADIYTRERSELNSFMRRMGSGFLLFLANMDLADEALELVESAGFRGEVMHGYEEDKVRDFSEGRLDCLIGASKPYGVLVRGIDLPKRIRYVIFYGAPRFEITLREVSEMEDPSIISLFSSLSRALGSEERKLAMKLRRNPSKEDIGRARQIIEDILKDEEKISSISSLADVIIDVRGRRILIPDIRTYLQGSGRTSRLYPGGITRGASLVWDEDPVLTSFIKKARAQEIDFLHLREVDLEKLRSEIDESRRIISSLKKGYELANLLKTALFIVESPSKARTIASFFGRPSRRFLDGLMAYEVTTGDYVLTIVASGGHIVDLTTTMGYHGVLIEDGTYVPAYTSIKRCNSCGHQFTDMDRCPRCGSTDLRDSRSVVESLRRLSFEASRVIIGTDPDTEGEKIAWDIYQLIMDSSGEIYRAEFHEVTKRAIIEALKSLRGINERMVEAQIVRRVEDRWIGFELSAEVQKRFGKRNLSAGRAQTPVLGWVIDRYREHQNKKVVSIIKGDGLLLRVDGRVGEEGASKIWIRELKIEEEVVKPPPPFTTDAMIGEANRVLRMSANMTMQLAQFLFETGLITYHRTDSPRVSDAGFRVASLVLGEDFVPRKWGEGGAHECIRPTKPLSAKELIDYVKEGIIAVEGLSKDHIRLYDLIFRRFIASQSRDGTLVKQVASVRVGESEFEVTRLVEARGGWIDWYPFLHITEPRLKEGMVDVIIEHQTVPSVPLYTQSNLVALMKERGIGRPSTYATIVEKILQRGYVIERNQKLIPTKLGIEVYNFLRDRFPDLISEERTRTLERKMDSIEEGAADYQELIDELYKEIREKIGKFIH
(962) Reverse gyrase [Methanotorris igneus Kol 5]
6
MVPIIFKNMCPNCHSDIESLRLDKGLTCKNCMEDDSVSNICKYLAEKNTLKALEDYCKLKNELKELEDVAERCGFKLLSIQRMWAKRVLKNKSFSIVAPTGVGKSVFGMITAIYFATKNKKSYIILPTTLLVKQTYEKIINMANKAGVEVNVVAYHSELSSEEKRVAKEKIEKKDYNILITTSNYLSKNPIDDKFDFVFIDDVDAFLKASKNIDKSLKLLGFSDEIIKKAYNILYLIRKKKIEDALKEREKLKEMISKINHGCMIVASATGKSYGDKVKLYRELLDFEIGYGMSKLRDVEDIYDENLSMEKILEYIKIFGDGGIIFVPIDYGLKKAEEIEEFLIKNGIKAKLIHSKDKKGFEEFKNGEIDVLIGVASYYGVLVRGLDIPERIRYCIFYGVPKFKIDLEETLKKENENISIEGLNEEELMELVKNTLKIKNFSLRKEDNKYYLLIPDVKTYIQTSGRTSRMTENGLIKGASIVLVDDAEVFEGLKKYMLFMYEGEFKRIDEIDVEKLIEKIDEDRRKLKETKEKNKVPDLLKSALMVVESPNKARTIANFFGKPSVRRINNKKVYEVCIGDWNLIITASGGHIFDLVTKEGYHGVLIGNNSYIPIYGTIKRVNGEQFVDEKNIEELIKRIKEKTNENIVIHDAKENIEILRDLASEVDAVFIATDIDVEGEKIGYDIYLNLKPFNKNIFRIGFNEITKRAIMNAIKIVKEGKSEELSLDENKVRAQVVRRIEDRWIGFELSKKLWDAFNNTYLSAGRVQTPVLGWIIDRYNEYQIKVPYLYLKLEDDISFGTIVDDETAKKIKDKDYVDVEVNVYEKDIYPNPPFTTDTLLEEATKRFGLSSDEVMKIAQELFELGLTTYHRTSSTRVSLDGMRVAREYLEFNDMLDYLKNREYYMEGAHECIRPTKPMDTSELIEFIKNNNIYLTKDHIKIYDLIFRRFIASQMKECKVEYEEITIKDLDTKVEGYTNIIYDGWTKIYNLKLRKLPKIEKNTLKIIEKSIRKVPKVSLYDEGEIIKLMKERGIGRPSTYAQIVKKLFDRKYVLKSKDKGKIIPTKLGIEVYNYLKNNYYNLICEERTRELENVMDKIEKGEVEYIKVLDELLNEIKSIT
(982) Reverse gyrase [Ammonifex degensii KC4]
6
MELFLLAHGCPNCSGSVTDERLAAGLPCPQCLPQAGNNLSLAAVCCALRKENKIRELSPFCRAEEGLKEFELFFRQVTGLNLSPLQRLWAKRFFLEEPFAIIAPPGVGKTTFGLTVSLYNPQKSLILVPTRLLVWQVAEKLSHFAEKAGSKKKILSMTGKAKEKKELMQSEYDILVATTQFFYRHWSEIASHPITLVFIDDVDALLKSSRQVDSLFYFLGYSPEEVERALRSPEGEPREAGKRPQRLLILSSATLKPRTNRVRLFQRLMGFSVQRAVSTQRRVVDCYEEVPDFARALARAAELVRQLGPGGLVLVSPEEGREGVKEATAYLQAQGIEAESYLELTPEELVSRLAEGSLEVAVGLAHPTNPLVRGLDLPHVLKYVIFVGAPSHFFPLDLSPAPGALHGLGLALFPLFTPEEQRQVLRELRYLRPYLNLPADAVSRYPALEKRVQAFASFLKEKLKDPSFWEKIRAAEDLNLREEEGKLYLVLGDATTYLQASGRVSRLTAAGLTRGLAITLCTERRVLLSLKKRLRALTPAEIEFIPLQEVDLAGVMRGIEEDRRRIKAGELADKEGPRTALVVVESPHKARTIASFWGKPGIRRVKGVLAYEIPADERHLIITASLGHVFNLSRQQGFFGVLTFNHHFLPVFDTIKIYRETGEELVDPEEVARYPEGTVWDKQEILRGLQHLAFEVDEVYIASDPDAEGEKIAYDLYLSLRPFNPHIYRLEFHEVTPSAFRRALENPGQVNLYRVQAQLTRRVLDRWVGFCLSRRLWQKFGNRHLSAGRVQTPVLGWVVARAEEGRQRKARLTFSLGEATFTLEVPDRELGQKIFGELEKLSWEILEISEEERSPLPPFTTDTILTEAAHRLRLSAPVTMKLLQELFELGFITYHRTDSTRVSETGRFLVAKPFILQHYGEELFHPRSWGEGGAHEAIRPTRPMTEAELRWMVGAGLVDLSQERALELYGLIFRRFMASQMAPARVRKAKVRFRVPSYAWETEVVVEQIAPGFALLWPNFSVTELRPEARLTGKEYRELPLAEPYTEGTLVQEMKRQGIGRPSTYAEIVATLLNRGYLVVRGGRLYPTRLGFKVYRYLKENFPEYADTALTREIEAAMDLIAEGKEDYQEVLQKLYKVREILA
(992) Reverse gyrase [Pyrobaculum arsenaticum DSM 13514]
6
MVPLVVYLHTCPNCGGPITSDRLVLGLPCRECLPEGTKAGSIREVVAALRRRRVLKGLAWVDAYLRGYEGFTEFFKKVVGFDMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFVLVAALHVAKEGKKALLIFPTSALAHQAYRKLLVFAERAGVSVRALAYHSLLSDREKKEVLDAVQRGEFDVLVVTSAFLPKYFDMLKAFKFDFVAADDVDSILRATSKNIDRILRLLGVSDSVLSTALEVINMTKQLRKAEVAGDLKEMERLSQQIAELRAKLHEEARRLRLGIFIASGALAKARRTLRLMLFREILGFDVGGRAEGLRNVVDLYTEASGDVVEQAVELLKRLGPGGIVYVQDRELGMAILERAKAEGLAVEHFFRPRRGVLESFEKGELVALVGLASSRSALVRGIDLPHVIRYVVFVGVPKFRFRVRLEEFSIPAYLTFLYNVRAVLASDLRYKADRLIGQLKRLAPYALSVQEALKKAAEGAELNGFDKHAVEVVKSAVEFVNSLLEREEIRKAIETSTEIRLTYVGGELYVLVPDVTTYIQGSGRTSRLYVGGLSKGLSVMIVDDAKVFQALRRELKLRFDEAEFAHIKEVDLDKVLQEIDRDRRIIRDIIEGRVAPERRSVELMKTVLMVVESPTKARTIANFFGRPSLLVAEGVPIYEVSTGDTVLMITASLGHLYELPTSLDRIEARQREMLLKWFGDFKTDGYDGGQYAVLVKEGAYIPVYNKIWRCRGGVYVDDVDVPPECKPLDVLEAIRNVAVEVDTVLIGTDPDSEGEKIAFDLYVSLRPYVQDIKRVEFHEVTRRAIINALANPREINFSLVKAQIVRRVEDRWIGFGLSKILQNKFQNPNLSAGRVQTPVLGWVVKTYEESLRNRMYNVDLQLEEGELRIQISREALDVLRKKKRVAIKLAGREVRSLNPPPPYTTDELLRDAVARLGLSADAAMRIAQDLFESGLITYHRTDSTRVSAAGVAIAREYITKRFGEDLFKPRTWGEEREGAHEAIRPTRPIDVEELRGLVNAGVIQLAIRPTRAHYQLYDLIFRRFMASQMGPSTVEVAKYQLEIDGYVVDIERVVGIKEMGFQTLYQVSRVEPELSTGTIDVVIKRYRVVRRILSQAEVLALMRQRGIGRPSTYARILQILSKRYYVYVTGRAKLMVPTKRGIEIYHYLEEAFGPLVDEERTRLIERHMDMIEEGKAKYDDVLNELFTEFRKEILPHLSA
(999) Reverse gyrase [Sulfurihydrogenibium azorense Az-Fu1]
6
MIYAIFEKLCPNCHGEISSYRLEKGLPCKKCLPDEDLDVCQHVKPGDIKQLCHLQDTLQTWQEHFQTYIKSKPWNLQNTWAKRVFLKHSFVLLAPTGIGKTSFGISMASFLAKQGKKSYILLPTKLLVKQVYEKVKNFGVDKKDILAIGLEKSNKEKEENKERLKNADFKILITTSMFLYKNFEIYPRDFEFIFVDDVDSFVKTAKNIDKALYLLGFTQEDIEKALILIKLKAKPNKTQEDWDKINQLTEYLQKQRKKITGVLIVSSATSKPRSNRVKLFRELLGFEISSPTFYLRNIVDSYDEEYSFEKLLYWINKLGKGGLVFIPSDKGKEFVDEVVEKLNKHKIKAVSYEELDDKNLKKFEEGKIQVLVGISSYRNPLARGLDLPHVIRYALFYGVPKISISLKLEENLSHMLWALTSIRSYVIKKFPEITIKINQWITQLQKYQNLTLDFIQNNPQLKEKIENLQKEIRDFFQRPEVLEVLKSSDEIVLKQKEDGYYLIVSDATGYLQASGRTSRLYAGGITKGLSLILIDEKSAFKHLNKRVKWFSEEIEFVNINQVNLDQLIKQIDEDREKVRNFLTNSTKTISSSDLLKPTLIIVESPTKAKTIANFFGKPVRRKINQTEVLETSTEGRYLMITASLGHILDLVKNIAYHGVIVEDKEIIPIYETIEGKEETVENLRRLAIENMEILLGTDPDAEGEKISWDLQDLLKPILKNIKRIEFHEVTKKAITKAINDPRDINENLVKAQIVRRVADRWVGFEYSQLLQKEFQKNWLSAGRVQTPVLGWIIKRQQEASKKIYVINVSIPVEDKKFSFEITFETKEEAEKFYQNLKEVEVVVEKRYEEVENPPPPYRTDTLLKDASDKFRFTLPQTMDLAQTLFELGYITYHRTDSIRVSDAGIYLAKEIITQEFGENYFKPRVWGEGGAHECIRPTKNITPEDLESLMLSKQIEGLSYNHIKLYKLIFNRFIASQMIPVKVEMADIVIKALNFEIKETIKTKVLQDGWNLVLGIETRPLIEGKIDVQEYKNLLQRPKAYLYTHGEIVKEMKEKGIGRPSTYATIIAKLLERGYVIERKGFLIPTNLGKTVYNFLTNKPNLKEFLSEEFTRKLEEIMDKVEEGKEDYITVLKDLFVKVRKIS
(1006) Reverse gyrase [Methanocaldococcus vulcanius M7]
6
MIPMIYKGMCPNCEDEIRSERLEVGVCEKCLPIDKKLEKLELCKNLKKEKTLKNLEKYCSVWNEFKKFEEFVKRLGFELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGIIMSLYLTKKGKKCYIILPTTLLVKQTHDRILSLIEKCKLNINVISYHSDLSTKEKKEAKEKIENGDYDLLITTSNYLAKNDINNKFDFIFVDDVDSLLKASKNIDKTLKLLGFDEELIKEAYKIIYLIKIGKIEEALKKREELKRKVSNINHGCLIIASATGKSYGDKVKLYRELLDFEIGFGMNKLRDVEDIYDEEFKKEEVLEYIKIFGSGGLVFVPIDYGVEKAEEIEKYLLENNIKAKLIYSKDKKGFEEFRKGEIDVLIGVASYYGVLVRGLDMPERVRYAVFYGIPKFKIKLKEYIDKLIEKGVLKENIDIENKSEDEIRHIVKEKLKMKNFSIKLENGEYFILIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDDKDIFEYLRKYMLFMYESEFKKIDEVDIRELIKKIDEDREKIKSGRSSGKTPDLLKSVLMVVESPNKARTIANFFGKPSVRKIKNRNVYEVCVGDLNLLITASGGHVFDLVTKEGFYGVKIEDNIYIPIYASIKKVNGEQFTDQKDLEDVIKQLMEKGEKITNIIDAKDNIEIIREIADEVDALFIATDIDTEGEKIGYDIALNALPFNSEIYRVGFNEITKRAILRAVESFKKGEELSLDENKVKGQIVRRIEDRWIGFRLSQKLWEVFNKNYLSAGRVQTPVLGWIIERYNEHKIKVPYLSLKLEGDIYIGKIWEGEFDKEEVSVETTTYEKELPPMPPFTTDTLLEEATKRYHIGTDEIMSIAQDLFELGLCLTPDTHIVLGDGRIKTIEEIVKSREKKEILSLDLDRKSIICDKIISFWEIKFSGNLKKITLQNNYEIKATPDHHILTLKDGRLKWIPAKNIKEGDYVVMPFNYNYKIRRSHPPSKIFEKIKKIVEIDNFNDVREPEFWYNLGLLFGNDRLSLQGSEKEHLVEELFSLKEDYINAFIAGYLDARGTFLKRGKEINIATFSKNKSILEKIGIYLHSIGILTMIQEHNGYFLVIDNKFLTTFTEKIVKYTKTKNLKEFCRTVIENKNKNKNVKKSNKKIKVGNIYNDVIFIKVKKVEDLFYDGYVYDLSIKCNENFISNGIISHNCTYHRTSSTRVSIDGMKVAREYLKLNNLEHYIKNRDYFMEGAHECIRPTKPMDTDELIEFLRENNIKLTKNHIKIYDLIFRRFIASQTKEAILEYEEIYIKDLDEKIEGYVDIKFDGWSRFYPLKLKKLPKIEKNSLKVLEKKLIKVPKVPLYDEGEVIKLMKERGIGRPSTYAQIIKKLLDRKYVIKSKDKNKLIPTKLGIEVYNFLIENYPHLISEERTRDLEEIMDKIERGEVDYLEVLKVLHEEILSIE
(1012) Reverse gyrase [Desulfurococcus mucosus DSM 2162]
6
MPDLPGSPSLPDGFKTHGVYRHACPNCGGPISDYRLIFKAPCEKCLRDEEFRGIVELAGKRGGIDRFQLLRLYAESSREGALRELVKREEMLRDFEAFFEKATGFKMWSAQKTWARRVLKGLSFSIIAPTGMGKTVFSLVTALYITQRARREGDPRGWRSYLVFPTTPLLLQAERKLRAFAENLGVSICSNDNWDNGDCIRILCIHGHLGKRDRETAMNRLKEGSFDILLTTSAFIHRNYELLKGKGFRLIVMDDVDAVLKSGRAVRRLLGIIGVEEEHIEKALTLVKARSRLVAASGEERARLEEEIRGLENEVSSVRSRINTMLLVNSATGRPRGMYPKLFKVFMGFEAGSKPEAIRNIVDSYVEPQGGIEEELVKLVLTLRDGVLVFVPVDKGVEYAERIVELLREKGLRAEAFHSKTSIELLDAFAKGDVNVLVGVATYYGVMVRGIDLPERVKYVVFAGVPRHRFSSMLEALSPTDILRVLAVLRDIAEGEKRDLIERLLGRISSRLRRMSPGAVLRLREELARKIRGESVEETPLLSTLFEAYKVIAEEFSKEETWQRISGLGDVGILKENDKYYMLIPDVATYIQASGRASRLYPGGITKGLSIVVVDDKRLLNGLVRRMRWIFEDFTMTPLSQVNLEELMKQIEEERRRVSEVIKGGTAAGTWVEPVKTALMVVESPNKARTIAGFFGKPSVRIVGNILQVYEVTIGSYVLSITASAGHVYDLVTDKSLPEAEGAEALYGVLRVDGRFIPVYTDIKKCSNGHQFTEELGGNTVECPRCKMDNKQSHVIRKLDVIKALRELAEEVDVVFIGTDPDAEGEKIAWDLRVLLEPYANEVRRIEFHEVTRKAILNALREPRDFDIRLVESQIVRRIDDRWLGFSLSEKVQKYAWMDYCLRYLFHKRGLVEKSTCCRPNGNMSAGRVQTPVLGYIIEETDARSRPERYVYRMKIYIERIGDLVEVSIPYIDAKNAGIVDTVKKRPHPVEVEVVSEEEVQLNPPPPFTTDSLLEEASRTLGLPATRTMEIAQDLFETGLITYHRTDSTRVSDTGVKIARQYLEDKYGEKAPHYFKPRTWGEGGAHEAIRPTRPIDSDRLVELVKEGVLSLPLRLTRDHVRLYDLVFRRFIASQMEAAKLRKLVLRVYIGDRSYETEIYTEAVWKGYLEVYENVRLLGRELGLKPGERVEAEIHDGNRVTPPRLRSHDVIRWMKEQGIGRPSTYAKIVQTLIDRGYVRVTGKVKALIPTERGRSVFNFLGKYYGNVVSVDTTRRLEELMEDISKNTVEYQSALEGIYREVTTAVIGNHRVNELLEKMYREKCSEEK
(1020) Reverse gyrase [Pyrolobus fumarii 1A]
6
MAGDGWRLHGVYWYACPHCGGPIGDDRLYHRLPCARCLPDDRLSLLEPNPDGTYDPRRVAELLEPREDSPYLALAELEREVERAEAFFEKAMGSRFWSVQRTWLRRVLRGKSFAAIAPTGIGKTTFGTFTAVYLAATRGVKSYIVVPTTPLVEQVEERARRFAEAIDPGVRIVAIHSRLPRKELKRRMDAYRNCDFDVLITTSSFMLRHVDEIISVLEGKCGQRFYLVFVDDVDSVLKSSKSVDAVLKIVGFSDEDIKAGWELLKLRREIARLSARARSKGEIDPRLAELIEKARELEKRFEGKRRCVCGRCNHRDCVSVLVVSSATGRPRGTRVRLFSVLLGFEAGSRPELYRNIVDTYVKPRDGIEEEVVRLVKRLGDGGLVYVPVDKGASYAERLAQLLSDAGVRAEPFTARNPDALERFRRGETQVLVGVAIYYGVAVRGLDLPERIRYAVFAGVPRHKFSARFEDPHPTNIMRVLGLLAEHAPDDVRSEAEKLLARLRRIVRRLSAAALQKLAEELRSGEVSSDAARLFQEALRFVREALSRSDVWEALEKAPDVAIVREGDKSYIMIPDVATYIQASGRTSRLYAGGITKGLSVIVVDDDRLLEGLRRRLRWYIGEAEIRPLEEVDLDKLLREIDEDRRRVRDVLSGRVKPEYLELVKTALLIVESPNKARTIARFFGRPSVREIAGLRAYEVSTGDYVLTIVASGGHIYDLAKTYYPLDVIPSWWLREFNFEGRVASIDEFVTGFDWSSAENKHGVFVAKRGSVRYLPVYTPLVRCPDCGFQSAANPSLAPNEEQTIRDVIKARLGKDVDPFDEKSLPRYCPRCGSPSVRTSLPVIEALRELASEVDMVMIGTDPDTEGEKIGWDVAALIAPFANKLVRVEFHEVTRKAILEAIRNPRPFNPRLVEAQTVRRVEDRWIGFTLSPILWRDFWLNYYCPRMTERLRKRLEAIRAKIRALRRRGMRVPDELKKRMERIEALLRACEGPNRNLSAGRVQTPVLGWVIDRWSRFSGEQKACAARRGLPSEECPRLQVTVSSDGVRVVFEAPGSLAPRLRPGTLVELVEVGREVVEENPLPPYTTDTMLADAWDKLRLPAPVAMQLAQELFEMGFITYHRTDSTRVSDAGIAVAREYIRQKWGEEGLEKLFRPRRWEPPRLIGVEAAHEAIRPTRPIDADTLRRLIEEGVIETPRPLTKRHLALYDLIFRRFIASQMAPARVELQVLEVRLGGEKLVEVKRRAKIVEEGFLMIYKPWEVEGEAPAGEYRVVSVRGRPETWPLTQAEVVRMMKERKIGRPSTYARIVETLHQRKYVKTLPKTGWLMPMPRGRLVYKYLAEELGSKIPVVRNMISEERTRELLEQMDLVEEGKVDYQVLLDEVYRELLEVEKALKELTGGTPTPPK
(1030) Reverse gyrase [Caldicellulosiruptor bescii DSM 6725]
6
MATGAKYYHSCINCSGINTDTRNEKGLPCEKCLKDDHLTENVFELLKGRGLLKDYQIYWNFHQNYKMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTVSLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEEFEKRFISCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAVLKSSKNIDTLLQMIGFSEDEIEKATERLRSKNRENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLDNSIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFSIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEILQTEKLRQLVSKYISKEDYSKIVNKIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKVSRKIQNDDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALRNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLDVPRIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGNEGAHEAIRPVKPISPEELKELAYEKYTQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFKINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSLTDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLLELYNDISVLLNN
(1035) Reverse gyrase [Metallosphaera sedula DSM 5348]
6
MNADERLPDVVYMGSCPNCGSDITSVRLGKGSVCERCLGEEIDIGSLQQLVEILQNAGTIKSLLREKNILEEERKVIDLFKRVIGSEPLGPQRSWIIRALRGESFPIIAPPGLGKTTFGIVMSLYYASRSEKSLMIFPTRTLVSQVVQKIQEMGKSLDFTPRLVYYVSGLTQSKKDELSKSLAEEDFDIFISTSRYVIQHLDEINKINYKYLFVDDVDAVLKSGKSSLTILKLMGFSDENVTKVRELLKTSRDNTSSFDEIRKIRERFAKDRVAIFSSATITRSNPVFTSLMGFKPGGATIYLRNVIDSYIIGTDIVSQTVELVKRLGPGGLVFVPVDKGLNFAREISQKIDFLKASVVSSNTTKKLEEFEQGSIDVLIGVATHYGLLVRGIDIPWRVRYAIFAGIPKFRFKLGETMHPLAMLRILTLLSVVLKDPEITRILRFVKYRLRRTSTAALAMLAKAVKDGALEDRTMIRAYEIVNTYLKDKRIVEAISKFGDISFSGDYISIPDYLTYIQASGRTSRLYGGHLTTGLSVLLVDDMILFDLLKKKLSFILDDMKWNPLDLDSQKIGDRDLQEIVKQIDKERAEIIRRRKIEPISMPMEKIKTVLLIVESPNKAKTISNFFSRPSIRDFDGLRVYETVIGDKILMVTSSGGHVYDLTTKDLGVYGVEVKSNGDVNVIPFYNTLKRCENGHQFTEYAEGGKCPICMSTNVRDKRSAINVLRRLVLEADEVLIGTDPDVEGEKIAWDLYLNLKPFNSNIFRAEFHEVTRRAITEALNSPRTFSINMLRSQLVRRIEDRWIGFKLSNKLKEEFWKEYCTKTLGNKDCDTENRNLSAGRVQTPVLGWVISRYEEYLRTKRTMYVAKAGNLNILIPKQQGIRKNSKIKIVIQSAERKQDTLGPFPAYTTDTYLSDASGFFFISAQEAMRIAQDLFENGLITYHRTDSTRISNVGIGIAESYLKDLLGERYREIFVPRSWGEGGAHEAIRPTRPLNGEQLRAMVEQGEIEPSKRLTYNHYRLYDMIFRRFLSSQLVPLVVEKEILQISAKKGDETLKLESDTLEIVTNVRLSKDVPIPSEILYIPFRSIGETLLTQIKDKLPAEIDAVITSSFQKSDHALYTQGELVSLMKQRKIGRPSTYAFIISTLLKRGYVFETMKVKRLIPSKLGQHVYEFLNSRYSNFVSEDRTRSLLERMDLIEEGKEDYRQVLKQLYNEIQDIR
(1047) Reverse gyrase [Methanothermococcus okinawensis IH1]
6
MIPIIYKEMCPNCNGEITSERLEIGVCERCLKEEKVFEKLELCKKLREEHTLNNLKNYCNTWKEFKEFNKFTKSLGYELLSLQKMWAKRILKNKSFSIVAPTGVGKSFFGILISLFLAKKGKKCYIILPTTILVRQNYEKILSLIENKLNINIIAYHSELSAKEKKKAKENIKNNNYDLLITTSNFLVKNIPNTAFDFIFVDDVDALLKASNNIDKTLKLLGFNEDIINEAYDIIRLIKIGRLNDALKKRKTLKNKISKIKHGCLVIASATGKSYGRKVKLYREILDFEIGFGMNKLRDVIDAYDEEFSKEKILEYIKLLGKGGIVYVSKDYGIEKAQEIEKFLLKKGINAKLIHSKDKKGFDEFKNGNIGVLIGMASYYGILVRGLDMPERVRYALFYGIPKFKIKLKEYIDDLKNKGKLKEDVDIEGKTKEEIKQILIEKLKIKNFSLRKDNNNNEYNLLIPDIKTYIQASGRTSRMTEFGLTKGVSIVLVDEKEIFEYLEKYMLFAYESEFTSIDNIDIKELIKKIDKIREKIKLGRAQGGVPDLLKSILMVVESPNKARTIANFFGKPSIRRMNNRNIYEVCVGDLNLIITASGGHVFDLVTKEGFYGVIINNISIPIYSSIKKVNGKQFIDQKDLEELLSVKKVEETNIMDSKDNIYIIREIADEVDAIFIATDIDTEGEKIGYDIFLNVLPFNKNIYRVGFNEITKRAILNALESFKKGDKLNLNENKVKGQIVRRVEDRWIGFRLSQKLWEVFNKHYLSAGRIQTPVLGWIIDRYNEHKIKVPYLSLKLENDIFIGKVWEKEFDKKEVKVEVKVYEKEFHPLPPFTTDTLLEEATKRFKISSDEVMNISQELFELGLSTYHRTSSTRVSFDGMRVAREYLKLNNLEDYLKNREYFMEGAHECIRPTKPMDTYELIEYLKENNIKLSKNHIKIYDLIFRRFIASQMKKAVVEYEEIYIKDLDEKIEGYIDIKFEGWSNIYNLRLKKLPKIEKNSLKILDKKVKKIPKVPLYNEGDIVKLMKEKCIGRPSTYATIIKKLLDKGYIIKSRAENKLIPTKLGIEVYDYLITNYFSLISEERTRALEETMDKIENGKVDYLEVLKELHNEILCIN
(1081) Reverse gyrase [Hydrogenobacter thermophilus TK-6]
6
MIKSLLLKLCPNCGGDITAERLIKGLPCQNCMPDEDKNLCEALKEGSLKKLCTALEQVSDWEKLFEKHIKSKPWSLQVSWAKRVLLGSSFALLAPTGIGKTSFGISMALYLASKGKKSYIVLPTKLLVKQVSARLKKMGADKKLLLAFGDEEGKKKEENKERLTKGEFLILVSTSMFLYKNYHLIPRDISFVFVDDVDSFLKTAKNIDKALYLLGFKEQDVEKAMNLIRIKEKFKKTEEDWEKIRELSNEIKSISEKVKGVLVVSSATSNPKSSRVKLFRELLGFEIGTPTFYLRNIVDAYADYQELSLAEWIRKLGKGGLVFVSSDKGKEEVEKLIRELEKANISAVSYEDMDESKLSDYERGKVDVIVGIASYRNPLARGFDMPHVVRYAIFYGVPKIVLSLQFEKNLSHLLWALASIRPYIAKHIKDYINRVDDWIVRLKRYQYISDQYMEDKKDLKERIEKLREEVKNFLMKEEVLRLLETSEDITLRFKDGDYQMVLSDATGYIQASGRTSRMFAGGITKGLSITLIDDKRAFNHLKKKVRWFSEDINFVPVSSVDLDSLLSQIEEDRKKVKRYLSGEAATERPDLLKPVLIVVESPNKAKTIANFFGKAVRRRIGQHEVLETSLEDRYLMITSSLGHILDLNKEAGFHGVYVNSQIVPVYESIEGKEEVINSLRRMSVEVSEVLVATDPDTEGEKIGWDIMELLKPYVKDIKRMEFHEVTKKAIVKAIKEPREFNVNLAKAQVVRRVADRWIGFEFSQYLQQAFGKNWLSAGRVQTPVLGWIIEREKEYRKKIYKVVVRVEKDGKLFRVEFSFENKEEAREFYNKLNYLEFEVLETKEEFKNPPPPYTTDSLLKDASDRYRFSLPKTMQLAQTLFELGFITYHRTDSTRVSDQGISVAKEYIKEELGEAYSHPRTWAEGGAHECIRPTKPLDTEELRSIVLSGQVEGIGKEHLMLYELIFRRFMASQTRPVKVRTLEVLIRALSSEQRHTLVVDVLEDGWDKFLHLETHPTLEGKVYVEDKKELRELPKAFLYTHGELVQDMKKKGIGRPSTYATIVEKLLERGYIIERKGFLIPTKLGKEVYEYLSKREEIKGFLSEEYTRELENLMDMVEQGSANYENILKNLYRSIMFLEPALEVER
(1082) Reverse gyrase [Hydrogenobacter thermophilus TK-6]
6
MIKSLLLKLCPNCGGDITAERLIKGLPCQNCMPDEDKNLCEALKEGSLKKLCTALEQVSDWEKLFEKHIKSKPWSLQVSWAKRVLLGSSFALLAPTGIGKTSFGISMALYLASKGKKSYIVLPTKLLVKQVSARLKKMGADKKLLLAFGDEEGKKKEENKERLTKGEFLILVSTSMFLYKNYHLIPRDISFVFVDDVDSFLKTAKNIDKALYLLGFKEQDVEKAMNLIRIKEKFKKTEEDWEKIRELSNEIKSISEKVKGVLVVSSATSNPKSSRVKLFRELLGFEIGTPTFYLRNIVDAYADYQELSLAEWIRKLGKGGLVFVSSDKGKEEVEKLIRELEKANISAVSYEDMDESKLSDYERGKVDVIVGIASYRNPLARGFDMPHVVRYAIFYGVPKIVLSLQFEKNLSHLLWALASIRPYIAKHIKDYINRVDDWIVRLKRYQYISDQYMEDKKDLKERIEKLREEVKNFLMKEEVLRLLETSEDITLRFKDGDYQMVLSDATGYIQASGRTSRMFAGGITKGLSITLIDDKRAFNHLKKKVRWFSEDINFVPVSSVDLDSLLSQIEEDRKKVKRYLSGEAATERPDLLKPVLIVVESPNKAKTIANFFGKAVRRRIGQHEVLETSLEDRYLMITSSLGHILDLNKEAGFHGVYVNSQIVPVYESIEGKEEVINSLRRMSVEVSEVLVATDPDTEGEKIGWDIMELLKPYVKDIKRMEFHEVTKKAIVKAIKEPREFNVNLAKAQVVRRVADRWIGFEFSQYLQQAFGKNWLSAGRVQTPVLGWIIEREKEYRKKIYKVVVRVEKDGKLFRVEFSFENKEEAREFYNKLNYLEFEVLETKEEFKNPPPPYTTDSLLKDASDRYRFSLPKTMQLAQTLFELGFITYHRTDSTRVSDQGISVAKEYIKEELGEAYSHPRTWAEGGAHECIRPTKPLDTEELRSIVLSGQVEGIGKEHLMLYELIFRRFMASQTRPVKVRTLEVLIRALSSEQRHTLVVDVLEDGWDKFLHLETHPTLEGKVYVEDKKELRELPKAFLYTHGELVQDMKKKGIGRPSTYATIVEKLLERGYIIERKGFLIPTKLGKEVYEYLSKREEIKGFLSEEYTRELENLMDMVEQGSANYENILKNLYRSIMFLEPALEVER
(1117) Reverse gyrase [Methanothermus fervidus DSM 2088]
6
MYRAIYKGMCPNCGKEIDDSRLNAKNPCKSCVEKKLQCEDYHELLEKIEEYLKENNNLYGWKEIYELHRDLKDIENLFEKATNSKFWNIQKTWFIRLIKGESFPIIAPTGVGKSIFGIFASLYYALKNKKSYIIVPTTSLVLQTVEKIKKFMEKTQIKVNLAFYHGKLKEKEKMKNKIENDDFDILVTTSQYLAINFDILKNKKFDFIFIDDVDAFLKSSRNIDRSLILLGFSEEIIEKGWELIKLKERGPKRNSEQIKKIENKIKEFKEKNKIGNLVVASATIKVKNKRIKIYRELLNFEITGEVPTIRNMVDSYIKTDEKIEKHLVKLLNILGNGGIIFVPTDQGIEKAKKIENYLKNNGFKVKLVSSADKTGIKEFKEGKIDYLVGVATYYGVLVRGLDIPERVRYTIFTGVPKHRFVINLDSPRLYSIIILLRVLIDVLKGNYKRKAESLYTKLQKIPKYKIKEIEKKLENGHADSRITKIYDDSVKFVRKIFKKEEIRKKIFSNEFLSMEIQNNKLCIKFPDLRTYIQASGRASRLFAGGITHGLSVVIIDDEKVFEGLKRQYKWQFQKHEFKAFEKLKLKKILNKIDEDRKKVKAIKKHGKFEIKNIVKSALFIVESPNKARTIANMFGNIGKRRIGRLTVYETNIGNRILMIVATGGHIFDLVNDEGFHGIKIENGHFIPIYDTIKRCRECGNQFVNNNGSTCPKCKSNDIIDTFENILVMRELAQEVDEVLIGTDPDVEGEKIAWDVMNVLSPYTSNLKRVEFHEVTRSAILKAIKEASKINIKRVEAQIVRRIEDRWIGFELSQKLWEEFDNTYLSAGRVQTPVLGWIIKRYNDFRKSETYFTKLTLENRMEIILEGKKETDYLEVKKVNKEEKDINPNPPYTTDTLLTDASRILGFPTTKTMRLAQDLFEMGFVTYIRTDATYVSDVGNIIARDYIKNEIGEKYFKARKWGKEGAHECIRPTRPIDSEKIIQLIRNNVIRTTKKLTSDHLRLYNLIFKRFMASQMTPVNLHYQKIVLGIDDEEIEIEGYTDIIDPGWTKIVRLPMKKLPEVKEGQKIKIKEIKTWKAPKISLFTEGDVIEKMKKSGIGRPSTYSKIVNTLLDRRYVIKTKLKKKLLPTKLGVNVYNYLIHTYEKLVSEERTRELEKVMDEIEEGSRNYQEVLNSIYEEIKQFV
(1120) Reverse gyrase [Candidatus Caldiarchaeum subterraneum]
6
MKSIYASLCPNCGGAITDEELIGNGVCSRCVSQDGRLKPGKYTKALELEERYREFADFFSRVVGSPPWSLQRTWIRRTFLGRSFSIVSPTGTGKTTFFIAMAIYQASKGKKSYIIVPTSLLAQQIHERALSMAAKHGEKAPKIAGYFSGMKKSEAEEMLQKIRDEEFNILVTTDRFLNTRFELLRGKKFSFIFVDDVDSFLKSARNIDKVLLLMGFDEEEIERQLSLVSRRSEKNEAGEHASREIAKPDSILLVAGATAKGRRTKRIQLFRRLLNFEPGGSIEFVRNISNMYLRPSKNMWEQVAELVKTHGGGCLIFVPQTAGVESAKELAKFLNSQGISAYAYERMDAKMLGRFELGEYDVLVGVASRRSPLARGIDLPERIRYVIFAGVPRRELNVSWREHRPSMLLSLLRNLYSILREKNESELVQVTGMLKKCVPTDREVLEIVREGLESSRQPEGFAGYVYSAVTRAHQLLKTYIGEEELRRVAENLDMRLRVDENGVSIILPDIDGYIQASGRSSRMYAGGITRGISILIVDDEKAFRGISRALETIYEETFQEYTLEQAREEFKQCDRDRQFLREIRTGSARLESLDILSSSLIVVESPTKARTLAYFFGKPARRVVDGLTVYESVGEGYVACLTACQGHLVDITTSQGFHGVWVHDGEFVPMYVDIRRCSKCGEQFTDSEVCPNCRSDKYFTKLSIIESLRKLALEFDRVFIATDPDTEGEKIGYDLYVSIWPFNKRIERLELHEITRKALRDAFKSPRSISLPLVEAQVVRRIEDRWVGFELSRRLWEFFGEKHLSAGRVQTPVLGWIIQRMEEAKKKRLVASMTFEDGSELMLDSIEDVDVVKRLYAEGVLNVEVADVKYVETVVPAVKPYTTDSLLRDASIFLRLSAAEAMDAAQTLFESGLITYHRTGSTYVSSTGLSVARNYLEENFPGLFVARHHGEPGAHECIRPTKPLSRKQLELYLQSGLIRVPMRIGDREFMLYDLVFRRFMASQMKDALVQRQICKLMILGKTYDIERIVDVIEPGFLHLYQVIKTVKALEPGVHRVLNLQIKSMQAVPFFREGDIIALMRERGIGRPSTYAQVLNLLYKRRYIFNDNGRVLATKLGKTIYGYLVSNFGSFVSEALTRRLEELMESIESGKVSYQEVLKELYRETLQISKTPARAA
(1125) Reverse gyrase [Thermoproteus tenax Kra 1]
6
MDFKTIRAIYLHSCPNCGGAVDSSRLAQGLPCSECLPRALKLENLKSVIQALKSEGSLKELATLDEVLRRYEELNVLFEKVVGFRMWGAQRLWAKRLAAGKSFAVVAPTGSGKTTFLLVSSLYMARGGKVLLVFPTSALAYQAYKKLLDYSARANYSGRIISYNTMLREQEREEALKRIEEGDFDILIITSAFLPKYFDVLAKYKFIFIATDDVDSVLRATSKNIERLLRLLGATDEALNLALDIIELNKKRARQMLGGDEKGLEESDVEIKRKREELRRLKARLKLGVFIASGALAKARRTTRLLLFRELLGFDVGGRAEGLRNVYDVYAKLSEDPRAQVAALVKRLGSGGIIYVQDKDLGRELVEYLKGEGIKAEHFFRPRRKVLEAFERGELDALVGLASARSALVRGIDMPHVIRYVIFVGIPKFKFRVKLDEFSAPAYLAFLYNVRGVLPQELKFKADRLIAQLRRIAPYTAGLEKVLTEGPKNSFEEYLLNVVKSAVEFVGLILSRDDVKRAIETSTEVKLTYIDGQLYVLLPDVTTYIQGSGRTSRLYAGGLSRGLSVILVDDEKVLHALRRELELRFDEVKFYDLAETDLDKILREVDSDRETIRRILSGSFKPEELSARDIMKSVLLVVESPTKARTIASFFGRPNMLIVGGVPAYEVSTGDMMLTVIATMGHIYELPTSLAKIEPSEKERVLRAVGRTLSEIYSPEDYAVFKTEDGYIPVYNRIYKCPGASYVDDTEVPENCQPLDIISTLRNLASEVDLVLLGTDPDSEGEKIAYDVYLALRPYVGSIKRIEFHEVTRRAIVNALSSPRDVNLPMVAAQMVRRVEDRWIGFGLSRRVQEAHGLAFLSAGRVQSPVLGWIVERYQSSRAERKFDVTIELEDGSIRLTLPEDSYKALKSEGRVRIKRLEGREVVLQPPPPYTTDEYMRDAVNKLGITAEQAMAIAQDLFESGFITYHRTDSTRVSATGIGIAREYISKRFGADLFKARPWATGEEGAHEAIRPTRPIDAEELRGLVAAGVIQPTIRLTRNHYAAYELIFRRFMSSQMREALVRVEKYEVEAGGYKAEVERVVEIKEEGFLRMYRTVEEARPLREGESPIKITYAKRHVELLSQADVLRLMKERGIGRPSTYAKILEVLSKRGYVVVRGRRKFMIPTKRGIEVYQYLKSNFGKLVSEERTRLIERFMDDVENGRRDYRAVLDELFEEFIEEVLKR
(1174) Reverse gyrase [Thermosphaera aggregans DSM 11486]
6
MLTYVLNPLYRSSCPVCGGDLTSRDIEEYGKCSKCRSRLDSSLNVFTLNKIIEDEVEDFEEFFKTATKGLTPWGAQKTWIKRILSGENTVLIAPTGMGKTTLLVAYALFASSRGKKILYITPTRALGKQIHARISGDAGSEHSVFYDSGLSKRRKQTLLEKIGKGDFKILVITNSFLGRNFDLLSKHEFDIIIVDDVDSLLRSEKNILRLLLLLGFNEEVVQLAKKRLQLLWRLMVSKSLNNEESYYSIVKEYLDLDAKIEASLKTLKRRQLIVASATGRIKGLMGRILKDLLQVDVSGITIYGRDVTDSYFLRSLDEASRELAALVKTLGPGCVIYVSPRHPFKQQLVKLSEDLRSILEREGFKIADATPANVLKLVSRQVDVLIGSASYYGSGVRGIDAPQSIKYVVFLGTPVFTVSLDSFLSNPNMLARILIELAEKTGIKSLREKAYTVRRLVYYLSPGETRLLRNVLKGKIPEEAVKPHEKLYSKYVELKTLYSETIREVEKYLDVNTVLEAGSITLLKSRDGYVALIPDAMTYIQASGRVSRLYGGRMTHGLSLILETPLLSNLVKGLEMKLKLINKDLGFRELEELDLSVEKEMAESTRTRSGEWLLKYRSVLIVVESPTKAKTIARFFGKPVSRRIGDVNVYEIPVKIGEEIVDLNITATRGHLYDLTTDPYTDNYGIIVETGLVTPVYETIKRCRVCGTQFTHEASCPRCGSGVFSDQKAIVNALRKLASEVDEVLIATDPDIEGEKIAYDVYLAVLPVNSNVWRIELHEITLQEFLKSIERKRSVDRNKVLAEIYRRSLDRLVGFSLSQDLWSRFGKRYLGAGRVQTPVLGMIIQRYREYVEGRCRKIELSLGSPLNTKYSVCVDNNSSLVDEARRAGKILLRKEGEEVVEIAPKPPYTTDEFLVDAARRGIPVSLAMKIAQELFEAGLITYHRTDSKYVSATGVSIASKYLASKNLRNLFKPSHWGEPGAHEAIRPVYPYDADDLMKAFTEGLIPLTIPLTGLHYSLYDMIFKRFIASQMKPFKAVKARFSLWVNGISLGTMEVYTRIVEEGFNAVAGIKTHEALGSVEEAEVPVKEVKTSISSRTFLYSEGDLVALMKKTGIGRPSTYSKIISSIERHGYIVKSRKKLKLIPTKTGVMVYDYVSTAYPDLTSIELTRRMEDLIDEISMGRLNAAEVIMDLIQSLSTRSLITVKTVNTFSSQL
(1180) NEQ434 [Nanoarchaeum equitans Kin4-M]
6
MKIYYNNVCPNCSGRISNERLIKGLPCENDYPYEEGTIEQVYEYLKENNKLKDWANIYNIEKAKKEFEEFFYKAVNNKPWSAQRAWFIRAYKGYSFSIIAPTGMGKTTFALVNALYWGKKGKKVYIIVPTRTLVKQLYEKINVFAERVGFDNIIVAYYGNNKQKKEAKELIKDGAFSILITSNQFLSRNFDLLKNNYFDIIFADDVDSIMKSSKNIDRILYLLGFSETTIEKAMQLIKLKISGKDLEKIRKMEEQLKELVRKEQRGILIAASATGSMRGLRVKLFRELLGFEVGAAKTTIRNIIDVYTEMRDYKKQTLELIKKLGNGGLVFVPTDYGIEKAEEIAQYLKENNIKAEAFYSGKSIELLDKYANKELDVLVGVAHYYGLIVRGIDLPHVVKYAIFVGIPRFRFSAKEKETKIGRILLLASTLSDYADEEFKKKLNTTYNMIKRVSTGALKMVEEAIEQNKELDGFLEELRKNIIYLRDKSFELINREDIIKKLEENPFIALERGDGINILIPDVKTYIQASGRTSRMYPGGITKGLSIILSDNEKLLRALEFKLKLLGIDLHPGSSS
(1187) Reverse gyrase [Pyrobaculum neutrophilum V24Sta]
6
MDLPYVVYLHSCPNCGGPITSDRLAAGLPCRECMPKEPRAASLREVVEALRRRRALRELSWVADYLREYSDFSSFFARVVGYEMWGAQRLWARRLVRGKSFAVVAPTGSGKTTFVLVSALYMAGRGRRALLIFPTSALAHQAHRKLLGFAERAGLNVRVVAYHSLLGEKEREEALAAVERGDFDVLVVTSAFLPRRFDLLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDEVLKTALDAINLAKQLRKAEVAGDLKEAERLERELASLRAKLQEAVRGLKLGVFIASGALAKARRTTRLLLFREILGFDVGGRAEGLRNVVDLYVEAAHDVVQQTIDLLRRLGPGGIVYVQDRELGMAVAAKAREEGLAVEHFFRPRRGVLERFESGEVAALVGLGSSRSALVRGIDLPHVIRYVVFVGVPKFRFRVRLEEFSIPAYLTFLYNVRSVLAGEARYRADRLIGQLRRLAPYALSVQEALKKAAEGAELTGFDRHAVDVVKSAVEFVNGLLAREDIRRAIETSTEVKLAYIDGELYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVVDDQKVFQALRRELKLRFDEAEFKHINEVDLGAVLEEVDKDRRAIRDIMEGRVSPAARGVDLLKTVLMIVESPTKARTIANFFGRPSLIIADGVPIYEVSTGDAVLMVTASLGHIYELPTSLKRVDPAQRAVLAKWFGDLKHDGYDAEEYAVIVKEEGFIPVYNKIWRCRGAVYVDDADVPADCRPLDVLSAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVSDIRRVEFHEVTRKAVLNALANPRGVSYPLVKSQIVRRVEDRWLGFGLSKLLQAKFSNQNLSAGRVQTPVLGWVVETYEESLRNRVYNVDLQLDDVDLRLQIPGDVLQVLRKKKRVAIRKTGEEERAVNPPPPYTTDEMLRDAVNKLGFSADYAMRIAQELFESGLITYHRTDSTRVSTAGIAIAREYVAKRFGEAAFRPRPWGEAAEGAHEAIRPTRPIDVEELRGLVNAGVLQLAVQMTRSHYLLYDLIFRRFIASQMEPSVVKVAKYAVEIDGHVLEIERAVDIVSQGFQQLYPVTAVEPELPTGTLDVAVKRYRVVRRILSQADVLALMRQRGIGRPSTYARILQVLAKRYYVYVAGRRKLMIPTKRGAEIYHFLRENFGSLVSEERTRLIEQHMDAIEVGKARYEEVLKELFDEFRRDVLPRLAYFST
(1198) Reverse gyrase [Dictyoglomus turgidum DSM 6724]
6
MIEAIFKNLCPNCGGDIASERLLAGLLCEKCLPKEVPQEVLCNHIKEEDYDLCSLKKKYGEWERVFKSFVGFEPWELQKFWAKKLLLGRSFALLAPTGIGKTSWGLATSLYFAKKNKKSYIILPTKLLILQSYEKLKDKIREEDLLVFGLDDTKKEKEEKRERLEKGDFKVLITSSMFLYKNVDIIPKDFGFVFVDDVDSFLKTAKNIDKALYLLGFSEEDINLTMSYIRMRKNGEEEVKRMQEEVRKIAKKAKGVMVVSSATSNPKSERIRLFKELLAFDVGRPVFYLRNVEDIYEEVEDLNKTLVERVKRLGKGGLVFLSSDFGKEYVDEVKNLLINEGISAESYDNLTPEVLEKYQKGEIFVLIGISSYRNPLARGLDLPEVIRYAIFYGVPKIVVNLDLEGNVRHLLIALASIRPLVARDKNLEKHVANLDRWMKTLKRYSSMLNPPRDKVEELRNIIKAFILSPEVYEKIKSADDIAIREENGKWVLVVSDITGYLQASGRTSRLYVGGISKGLSYILVEDKKVFNNLVRKSRWWFSTDIIFKESNTVNLDEILKQIDEDREKIRKKEGRRDDFLKPVLVIVESPHKAWTIANFFGRPISRNVNGQELFEVITEDKYLVITASFGHILDLNKEIGYYGVIENGKFIPVYEPIEGKEKIISGIRDASKEFEMILVATDPDTEGEKISWDLKNLCSPFTKEIRRMEFHEVTKKAILNSLKEYRDVDENLVKAQVVRRISDRWVGFELSQLIQRIFYKNYLSAGRVQTPVLGWVIERAKENKKRVYLVLIKKDGLDLRFEFENKDEAQKFYNELKYIEVTKETEKVEEKSPLPPYTTDAVLKDASDRFKLSVSRTMEVLQELFERGFITYHRTDSTRVSDTGINVAREYINEQFGEEYFRGRTWGEGGAHECIRPTRVLDVEDIKAMIYSGELEGFTPDHLKIYDLVFKRFIASQMRNVILRGYEVLVKAIDKEQKLDVYEEVVQNGFDKIFPIKLAKIPEGEIDVVNNKFFYSIPKVPLFTQGSLVEEMKKRGLGRPSTYATIVSRLLERGYVIEKNGYLIPTPLGEKVYQYLNSDQEKFRFVREDFTRELEELMDKVENGERDYQEILKSLRNELEKV
(1218) Reverse gyrase [Caldicellulosiruptor kronotskyensis 2002]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEKCLKDDHLTENVFELLKGCGLLKDYQIYWNFHQNYKMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTVSLAQQSFERLNQFKSKIQNTDVIRILLFNSSMKKSEKEEFEQRFLSQDFEILIVTSQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNRENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENSIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFSIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEILQTEKLRQLVSKYISKEDYSKIVNKIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFDSLKSRLMFLLDEEWMEENEVDFESLMEEVKESRKIQNDDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITQDGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKDILKTLRELALEVDEVLIATDPDVEGEKISWDISQYLKPANSNIKRIEMHEITRYGLDSALKSPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKNYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEEECKKVEAEVVEQKIEEIPAPAPFTTSSLLSLASQKLNLGVQQLMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKILVQKVHFRINDIEIVKDIPVKVEEEGWLEFIPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLQELYNDISVLLNK
(1219) Reverse gyrase [Pyrococcus furiosus DSM 3638]
6
MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS
(1220) Reverse gyrase [Pyrococcus furiosus DSM 3638]
6
MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS
(1233) Reverse gyrase [Thermotoga naphthophila RKU-10]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLLEESPSDIYRALLERKTLKEYRFYHDFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLAGKGKKSALIFPTVTLVKQTLERLQEFADEKVKILGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIKKAFSAIKQGRIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVERLVSVARNITHVRISTRSKEKLIELLEIFRDGILIFTQTEEEGKELYEYLRRFKFNVGETWSEFEKNFEDFKSGKLNVLIGVQAYYGKLTRGVDLPERIKYAIFWGTPSMRFSLELDRVPRFVLARVLKEMGLIKVQENPDVEGLRKMAKERLSQEEFVEKVKEIFRGAVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEESEANWKELIHEVEESRKRIEGELSDKSKSLLIIVESPTKAETISRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEEDGKFVPVYNSLKRCRDCGYQFTEDRNECPVCSSKNIDDKTETLSALREISLEVDEILVATDPDVEGEKISWDVTQYLLPATRSLRRIEMHEITRHGFKKARENVRFVDFDLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLLLENGVNLEVEGKITDDVVAVVELKEVEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLKKIGKEDIFTGRSWSTEGAHEAIRPVKPIDARELEEMLEEGLITDLTKKHLRVYELIFNRFLASQSAAVKVRKQIVTVDVDGNRVGIEQIIEVLKNGWDFFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFSQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDRYKRVRPTRLGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(1248) Reverse gyrase [Nanoarchaeum equitans Kin4-M]
6
MLRLEEIDLDTIKKELDEERKKVEEIMKGNIPTEIKDLIKMVLFIVESPNKARTIANFFGKPSVRRIGNIKAYETTTGKYILTIVATKGHLFELTLKEEGVYGVLKEKEYVPIFSPIKKCLDCGHQFVDEDKCPRCGSENIDDASDRIKVLRDLAQEADIVLIGTDPDAEGEKIAYDVYSIIRPYNKNIYRAEFHEVTRQAIIKALEEIRDINTNRVKAQLVRRIEDRWIGFALSQRLWSRFKKKTLSAGRVQTPVLGFIIKRYEEYKKNRAHYYAVKTSDFEVTFISDDPLEKYDKTIKIEKIEEKESEKKPLPPYTTDSLLRDAVIELRLSVDKIMALAQNLFEWGLITYHRTDSTHISNLGIQIAQTYIENTFGKEYFYPRHWGEEGTHEAIRPTKPIDTETLIKMLREGDIQIQGITKEHIRLYDLIFRRFIASQMKPFIAIETKFNAVWSNLNTTIEGITDIKENGWNLIKPIKLLAIKEGEYEVIDVKHWIGSKVPLYTQADVIELMKEQNIGRPSTYATIVKKLFERYYVIEKNQRLIPTERGIKVYQYLTERFGHLVDVKLTADLLEKMDRIENGELDYMDVLRSFKKELIEIWKTKETKYIADGIYKWKEYSVPAIVYERYEKILKRKKVYPEYLTPWSRAIYNALPLDNEIEKQTLALAIEKDFEILTKKPILREYKKKYEHLKNLVDQLL
(1264) Reverse gyrase [Ignicoccus hospitalis KIN4/I]
6
MYASYRRSCPSCGGEIEDVNLSLGLPCDKCLRVVGLESLKLDPSKKDSPSVRRRLIELGGPLGESLKLEEELESLEKVFQEVLGAPMWSAQRAWALRALRGESFSIVAPTGMGKSTLGALLSVYLSHKKKKKSYIIVPTTPLVDMMFRKVSAFAEAFGVRAVYFHSKMSPSQRKEMKERLLSGDFDVLITTSRFLINNLDLLKNYEFGFVFVDDVDSVLKSPKNVDRILMVLGLQESDVKRLEEVDKELSRKAQVLTKLQDLQKRYQLLKEMRELEEELEDLKRKVKGNLIVSSATGRAKGNRVRLFTRLLGFTPGGVGEGVRNVVDSYSRSSDVVEVVKKLGKGGLVFVPADLGAKGAEEVAEALRAAGVAAEVATSERIGVIKDFEEGRVEVLVGVATHYGVLVRGIDLPHVVRYAVFVGVPRFKFKLKLEEPSPMTIYRLCSLAARFFEECASLYAKLRKWVQRLGPAGLQSVEEALKEGSASTPASKDFMEAYTKLKEIIEKTDFIEKLKESGEVDVVAEDSLYVLIPDAATYLQASGRTSRLYAGGVTKGLSVVLVDSEPLFRGLKKRLAWVVEEWKEFESLNLSELLKEIDEDRKKVLKVIRGELKVEEVRDLMKTVLMIVESPNKARTITSFFGRPSVRQVKGVKVYEVTLGDKLLYVAASGGHVYDLVEEADPCNEEPCMLFGIRVKDVPEEVLSSIKRCAVCGHQFSGDVKECPRCGSPFIKDAKDVVDGLRELAQEVDEVLIGTDPDTEGEKIGWDLKNLISPFAKKIRRAEFHEITKKAILKALENPRDFDMGYVWSQMVRRAEDRLTGFTLSPKLWFELWPQLCEVSKEMKKKLLGCPLTRNLSAGRVQTPVLGWVIQRYEEYAKSKKKFYIIRFDGRELEFSEDELRGFSKKLAIDGKVKILKVEEEVEELKPLPPYTTDTMLEDASKLGLDPSRAMRVAQDLFEMGFITYHRTDSTRVSDAGIAVAREWITSKFEGLFAPRRWGEGGAHEAIRPTRPLSAEDLKRLIEEGMITPPRELSKQHFMLYDMIFRRFMASQMKEAKVKKAVYEITVEEGGAVVGKKVLEKYVERVFDGFLLVYPIVKIESLPEGEYEVKEVRAVSRHTVPLYTQADLIRLMKERGLGRPSTYAKIVSTLLERRYVTLSKVGKKLVPTVRGYAVYSYLTGKVVGAGWVRKALEVIINPEGKSKYFQKLVEEEATRRLEKVMDEIAEKKDEKMYINVLKDIIEETKVIPFLSDKGAQPSLR
(1324) Reverse gyrase [Pyrolobus fumarii 1A]
6
MAKLTLLYEAGCPNCRGRIDEERLIKGLPCWECLPLLPEAERYLSGLDWRERVLAVARLLEEHGKLEGWAWLAREEDELSIFERFFERATGSRPWSVQRQWARRLLRRESFAITAPTGTGKTTLLAVYALYSAVNGSRVYYLLPTSSLAKQVAERLQLLAHNAAVRKRIVYYHSLLRASEKRAQLEAIENGEYDILVTTTAFLSRRWGLLERTMFDTIIVDDVDAILRDSVNVERILMLLGAKPDEIRAATRLVKLSLRVRANPALARRYASEIEELKRVVNGVAGRLGQLVVASATGRARGFKRLVLGKLLGLSVGSIAGYARNIAEYKLLASSPEDAIEKLVETVAKMGPGGLVFVAKPLGVETAKLVVNRLGERGVRAGLAIAGKRVIEKFERGEYDVLVGVASYYGVMVRGLDMPYRVAYALFLEPPFNRTPIEKALQSPRRILALAKALDVEGYREYARILSKMTPDEVELLRAVLQGRLEAGGRLAEAAEKARSLASAILEKLRSVTSEVPAGYSILTVSSSGAYVATPDPYTYIQASGRTSRLIKGYMTRGVVIVVSSAPLLLERFEDRLARLLAGFELREYNEKEVLEELEKAWESRRAPAVSRSALRMNIETSLVIVESPTKARLIAGFWGKPARKEYDGVNVYETVAYNPKSGKTHVMLIVSVKGHVYDLTEEPVGKHGVILEGSDVKPVYAPIVRCRDCGAQHAIVAEQCPECNSVNIEDKRRIIELLRKLAPLVDTVYIATDPDYEGEKIAWDIYTLLKPYAKNIKRIEFHEVTKKAILEALANPRDVNRRLVEAQVVRRVEDRWIGFELSQHLWKVFNARWLGAGRVQTPALGFLVERLEEWKKGRCYALIARLPWGRVKLCYPDSRTAREALREALEKGVEVEILEANIVSLTPPPPYTTETLLYDASRLLGYTAEKTMRLAQELFENGLITYHRTDSTRVSDAGIAIAKSYMQRRGHAKLLMPRHWGEGGAHEAIRPTMPLDADELRDAIAEGEVRIVTRLRESHYKLYSLIFARFMASQSIPARVERVRLRVTVGNVSVEDVVARKVIEAGFLTFYPHVIPVYNVQEGRVKPMGARIVRTSTVRLYTHGELVMEMKRSGIGRPSTYAKIIEALKRHGYVVESRYRKYLVPTSMGRRVYQYLVTEFRPLVSLERTRLVESLMDSVASGEAEACRVLLELLEEVEGMVARVEAGRGAGLGENLAA
(1325) Reverse gyrase [Thermoproteus uzoniensis 768-20]
6
MDFRVLPALYLHSCPNCGGAVESYRLAEGLPCSECLPEEVAGSDIRRVIENLRRRNALRGLAPLADVLRRYEEIANLFEKVVGFRMWGAQRLWARRLAAGKSFAVVAPTGSGKTTFLLISALYMTSRGKALLVFPTSALAYQAYKKLLDYSSRAGLAPRIVTYNTMLKPQEREEALKRIEAGDFDILVITSAFLPKYFELLARHKFAFVATDDVDSVLRATSKNIERLLKLLGATDEVLGKAFELIELGKKRGKAVLAGDEKEAERIEREIEKAREELRRIKAELRLGVFVASGALAKARRTARLLLFREILGFDVGGRAEGLRNVYDLYVKMAEDPKTQVAELVKRLGGGGIIYVLDKDFGKDLVQHLQASGIKAEHFFRPRRKVLEAFEQGQLSVLVGLASPRSALVRGIDLPHVIRYVVFVGIPKYKFRVKLDEFSVPAFLSFLYNVRAILPQDLRFRADRLIAQLRRIAPYSARLDKILKEGASNSFEEYVLGVAKSAVEFVASLLSRDDIRKAIEASTEIKLTYIGEQLYVLLPDVTTYIQGSGRTSRLYAGGLSRGLSVVLVDDEKVLNALIREMELRFDDVRFEELSKADLDGILKSVDEDRENIRRILSGMLKPEELASRDLMKSILLVVESPTKARTIASFFGRPNMLIIGGMPAYEVSTGDSMLTVIATMGHIYELPTNLQRVAEDERRKIWRLVKPVAAGPYSPMDYSVVKTEAGYVPIYNRIYKCPGSSYVDDLDVPEGCKPLDMISTLRELASEVDAVYLGTDPDSEGEKIAYDVYLILRPYVGLIKRIEFHEVTRRAIMNALASPRDVNLSMVAAQIVRRIEDRWLGFGLSRKVQEAHGLAFLSAGRVQTPVLGWIVERYENSKAERKFDVVLKIGDGQIRLALPEDVYKALKENRKARISLLEEKTETIQPPPPYTTDEYMRDAVNKLGISAEEAMSIAQDLFESGFITYHRTDSTRISTTGIGVAREYVARRHGADAFRPRTWSAGEEGAHEAIRPTRPIDAEELRGLVAAGVIQPTIRLTRNHYAAYDLIFRRFMASQMREAEVVVARYALLLDGFNAEVRRVVEVKNEGFLAEYRSVELEPRLPTGEVDVEIAYAKRLVELLSQADVLRMMRERGIGRPSTYAKILEVLSRRGYVVVRGRRKFMIPTKRGIEIYRYLRENYGKLVSEERTRLIEKYMDDVENGRKNYVAVLDELFTEFLQEVLTRQ
(1329) Reverse gyrase [Aciduliprofundum boonei T469]
6
MIPVIYGELCPQCHDKLSWKEIENNLCENTGKELSRTRESEIYGEFEKFFVEKFGSKPRAIQRMWARRVLAGKSFAAIAPTGIGKTSFGILMSMFLARKGKKSYLLVPTTIILKDMVKKFEDLGEDIAFYHSKMKGEEKKGMENRIKEGKFNILITTTAYLARNHKNLYGKFFHFIFVDDVDSLLKRSKNLEKVLKILHKKGVLMVSTATGTKGYNTKILRDKLGFDVGNMRNAVRNIEDIYASKDTLKDILNAMGSGALIFAPTAKEAKTLADRIGDKAGLVIEKDKRAYDDFQAGKLDYLVGVSTPYGSLIRGIDMPDRIRYVIFYGIPRFKINAENLDDFGDKLMLSLAYGLRDYGFDEYIKNRNVKEIREKLKSILQNRKDIRGEDFIYKNGHIIFPDVKTYIQGSGRASRLYAGGITKGASFLLDGDDMVEIFLQRAELYGIEFKSLEDVDIESLKREIDRDRRRIAEKVEEKDVITPSLFIVESPNKAKHIAHFFGKPNLRIIGNAVVYEVAVGDRVLTIAPSLGHTVDLSTTQGYYGVVIKTGLFIPVYSPIRKCRDCGYQFTEGNKCPVCGSEDIYNAREQIEILRRLAYECEDVIIGTDPDTEGEKIAWDLRNLLSPFAKSIKRAEFHEVTKDAIIKAIRESREFDENLVKAQIVRRIEDRWIGFELSHILWNLFGKKNLSAGRAQTPVLGWIIERYEKSKEIREEYFIKGTDVKSPWKENVLAKVEKIGDEVKDYVVPPYTTDEILKDANTILGLGAREAMNILQDLFESGLITYHRTDSTHVSQEGMSIAKKYLGEDFRPRRWGKEGAHECIRPTKPWSAEDIRRFVNEGILNLEIQDEALRVYDLIFRRFMASESVGKIRISKYKVSAKGKVLEIPLIVEAYGKSVELYPYRIKVYRPLPTGMVRIEVEKRKIKLAPYTQADVIRLMKDRKIGRPSTYATIISKLFKRDYIVERSGKLIPTRIGIEVYSFLSTNYGKFVSEERTRILERKMEDVENGNRDYLYVLNELYEEIGKIRGN
(1330) Reverse gyrase [Aciduliprofundum boonei T469]
6
MIPVIYGELCPQCHDKLSWKEIENNLCENTGKELSRTRESEIYGEFEKFFVEKFGSKPRAIQRMWARRVLAGKSFAAIAPTGIGKTSFGILMSMFLARKGKKSYLLVPTTIILKDMVKKFEDLGEDIAFYHSKMKGEEKKGMENRIKEGKFNILITTTAYLARNHKNLYGKFFHFIFVDDVDSLLKRSKNLEKVLKILHKKGVLMVSTATGTKGYNTKILRDKLGFDVGNMRNAVRNIEDIYASKDTLKDILNAMGSGALIFAPTAKEAKTLADRIGDKAGLVIEKDKRAYDDFQAGKLDYLVGVSTPYGSLIRGIDMPDRIRYVIFYGIPRFKINAENLDDFGDKLMLSLAYGLRDYGFDEYIKNRNVKEIREKLKSILQNRKDIRGEDFIYKNGHIIFPDVKTYIQGSGRASRLYAGGITKGASFLLDGDDMVEIFLQRAELYGIEFKSLEDVDIESLKREIDRDRRRIAEKVEEKDVITPSLFIVESPNKAKHIAHFFGKPNLRIIGNAVVYEVAVGDRVLTIAPSLGHTVDLSTTQGYYGVVIKTGLFIPVYSPIRKCRDCGYQFTEGNKCPVCGSEDIYNAREQIEILRRLAYECEDVIIGTDPDTEGEKIAWDLRNLLSPFAKSIKRAEFHEVTKDAIIKAIRESREFDENLVKAQIVRRIEDRWIGFELSHILWNLFGKKNLSAGRAQTPVLGWIIERYEKSKEIREEYFIKGTDVKSPWKENVLAKVEKIGDEVKDYVVPPYTTDEILKDANTILGLGAREAMNILQDLFESGLITYHRTDSTHVSQEGMSIAKKYLGEDFRPRRWGKEGAHECIRPTKPWSAEDIRRFVNEGILNLEIQDEALRVYDLIFRRFMASESVGKIRISKYKVSAKGKVLEIPLIVEAYGKSVELYPYRIKVYRPLPTGMVRIEVEKRKIKLAPYTQADVIRLMKDRKIGRPSTYATIISKLFKRDYIVERSGKLIPTRIGIEVYSFLSTNYGKFVSEERTRILERKMEDVENGNRDYLYVLNELYEEIGKIRGN
(1407) Reverse gyrase 1 [Aeropyrum pernix K1]
6
MASARAASRGVYRYLCPNCGGPNSEERLSRGLPCPRCLPRLPRKGVSGWTGLARLLRREGTLGAGVKAMASLEEEARSLWRFFEKAVGSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAASLFYACKKGMRSYIVLPTTTLAANVARKLESMVESTGCGRVRLLVIHSKLKTSERREAMERFEKGDFDILVTTAAFARKYADRLSGYRFRLVFVDDVDAVLRSARSVDAILKIVGFDEEAIEKGLEVLRLQREQARLVGLLQSQREEVREEARKKLLEVKRRLERLEAEIEARRGRTASLIVSSATGRPRGARVRLFRVLLNFEAGGRGDIGLRRVIDSYTHPTDGVAEKVVELVRRLGTGGLVYVPIDMGVEYAERLAEELRRAGVKAEAYHAKKPLELLDRFAEGEIDVLVGVANYYGTLVRGLDLPARVRYAVFAGVPRHKFGSDIGDPHPSRLLRLLSILAESRIEEVASAARSHMGRLRRMLRVLSPAALQMIAERVARGEVEGGYDRQVLEAYQFLREALARDDVWESLRELDVGIVREGGRTYILVPDPATYLQASGRTSRLYAGGITLGLSVVVVDNEPVMRGLMKRVSWMAEVDWRRFEDLDLQSILREIDEDREKVRRVVKGLYRGVELVRTALLVVESPNKARTIARFFGQPSVRLLPGGGRVYEVATGDKILMIMASGGHVFDLVVRVDGRDLEAAGGEPEHAIFGVLRYRLGGNGAAAYTPVYTSIKRCLDCGYQFVDEASRCPRCGSELIRNSLSTVEDLRRVAWEADEVYVGTDPDTEGEKIGWDVALALRPYAPDIKRLEFHEVTKKAILEALSNPRSFDDNLVDAQVVRRVEDRWIGFTLSPLLWCDFWPRYCKRVLEEYGEKRPHMDRERCAKYKAYYNLSAGRVQTPTLGWVVDRTLAYRKKVWLYRVVHDSQLLFAVRSDDPEVPESVKRVLDNWVKHHKKTGIEPWLDVKAVVEKEEWTALPPPPPYTTDTMLRDANRLLGLGSAEAMRIAQDLFEWGLITYHRTDSTRVSDRGMQVAREWLETRFGGLAGQLYRPRRWGEGGAHEAIRPVRPIDVERLQLLVEEGVIELPGTLTRRHLRLYDLIFRRFMASQMREADALRVVYRLRVPELDGYTLTLERVVEIGRPGDAEGVTRGFTLVWPYVRPQPRLVEGREAWIRARVEGRQVPKAYPYTEGEIVEEMKTRGIGRPSTYAKIVETLFRRRYVIEVSREEGRGAGFVVATSRGINVYNYLTEELRSADEEEYGGRIAGILRRVPSLVSEDRTRELERQMDMVEKGDASRDDVLESVFNEISDLALLLNIEHPIKHRSRAEGNTQGNTWVSNFVACAVKSPEVSRVWGAGVG
(1506) Reverse gyrase [Thermotoga neapolitana DSM 4359]
6
MAVNLKYHHSCINCRGVNTDERNERGLPCEVCLPEESPSDIYEALLERRTLKDYRFYHRFWREYEDFRNFFKEMFGKNLTGYQRLWAKRTILGKSFTMVAPTGVGKTTFGMVASLWLARKGKKSALIFPTVTLVKQTLERLRNMSEDAKIIGFYSSMGKEEKKKFEESFEKDDYHILVVSTQFVSRHREELSRKKFDFVFVDDVDAVLKASRNIDTLLMMVGIPENVIKKALSAIKQGKIYERPDNLKTGILVVSSATARPRGIRPLLFRDLLNFTVGRLVSVSRNITHVRISRKSRERLVELLRVFRDGVLIFTQTEEEGRNLVDYLKGQGIRVEGTWERFEENFDAFKNGDIDVLVGVQAYYGKLTRGVDLPERIKYVIFWGVPSMKFPLELDRAPKFVLTRLLRESGLIKGREVNEEELRKLAKSHFSQEEFVERVKEIFRGSAVRGEELIIPDIYTYIQASGRSSRILNGVLVKGLAVIFEEDEEIFESLRTRLLLVAEEEILEESEVDWEKLIREVEESRKSLKKEFSDTSRSLLIVVESPTKADTISKFLGKSSSRRERNILVHEAVTDEGIILFTATRGHVYDLVTRGGIHGVEEKNGIFVPVYNSLKRCRSCGYQFTEDREECPICSSKDLDDKTETLRALREISLEVDEILVATDPDVEGEKISWDVTQYLIPANGSLKRIEMHEITKYGFKKARESVRFVDFNLVKAQVVRRIQDRWIGFELSGKLQKQFGKPNLSAGRVQSTVLGWIVDREEEYRKSEKNFTLITLENGAQLEVEGKVSVDAISVSKVEETEEDIAPPPPYTTSSALSEISQKLRLGVQETMDILQDLFEKGFITYHRTDSIRVSLEGQNVARSYLRKIGKEELFTGRSWSTEGAHEAIRPVKPIDDKEIEEMMEEGLITDLTKKHLRVYSLIFNRFLASQSSPVKVKRQSVFFDVEGKELKKEYVVEILKDGWNLFMPLTISPRFEHRSYRILERKIYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFKRGYVYEDKYRRIRPTKLGVMVYSFLKERYERFVTEETTRRLEEIMDRVEKGEEDYQSTLRLLYEEIKSLTEEG
(1567) Reverse gyrase 2 [Aquifex aeolicus VF5]
6
MALELIERGCPNCGGVISSDRLEKGLPCSKCLPKPTEEKVCDALEELKTLKYLKPFCDTDKSLERFINFFEKAVGAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMSLFLKGRVLAIFPTRLLAQQAGDRLSELAQKVGVNKKILIYQSKKNIREQFLNGDWDILLGTNMFLHKNFENLINFKFKLIFIDDIDSFLKRGKNVDYLFKLLGFSGEEIKLALKENKTQRDYDRLARIRKRKRDTVLIVSSATLKPRGKRAYLFRNLLGFDVQKAITTLRNIVDVAEPVKDLEEALEKSVELIKKLGKGGLVYLSVFYGKDKVQEVKEFYRKHGINAVSYLDYKPEELYQILEKGEFDVAVGISHITNPLVRGIDLPHIIRYAVFLDPPKHVFPTELTLSPPLLHGLLLTLLNLFEGDDRLKAIQYVMYLKRYLTLREEQLDNYPRIKERVEEIKNFLENYLKDENFLKKIKESEDISLVPKEGKLYIVVGDANSYIQASGRTSRFIAGGMTKGLSVVYYSDPKAFYSLKKRLALYYMTQEIEFKRLSEVDLNKLIKEIDEDRKRAREILQGKGVAQIKDLFKTTLVIVESPNKARTIAGFFGKPQMRLVEDSVAYEVPLGDRLLVITASLGHVLDLVTDKGFFGVLDDTYPYLPVYDTIKICRETHEQHTEYEYLKKRCKGKIEDKLEIIKGVREVSYEVDEVFIATDPDAEGEKIGYDLYLLSKPFNFNIKRAEFHEVTPKAFREAIQNPREVDLNLVKAQLVRRILDRWVGFTLSHILWDAFGKKWLSAGRVQTPVLGWVIKRYEESKEKKGEILLHVNDFPLKIEIEDLMFAKEIFKDLELADISLSNPQEEEKRPLPPYTTDTVLEDANEKLHLSAHKTMKILQELFEAGYITYHRTDSTRVSDAGKYLVAKPYITKMFGEEYFYPRSWGEGGAHECIRPTRPLEPKDLEFMITAGIAEFEDPENALKVYELIFKRFMASQMRPAKVITEEIILKLPYFEWKERVVTEVKEHGFDLMYPTFKVFPKKEKLEITHKEFREVPKVYPYTQGTLIQEMKRRGLGRPSTYAQIVQTLLERHYVVEEKGFLIPTDLGREVYEYLTKHFPEWTSEELTRKLEEAMDKIERGELDYMEVLKEVHRIKVLLKEEKAFKK
(1572) Reverse gyrase [Sulfurihydrogenibium sp. YO3AOP1]
6
MIASIFKNLCPNCGGDITSERLYKGLPCDRCLPQEPKEEVCDVLKKGKFKILCDIDDEVSNWQNFFSKHIGSHPWSLQITWAKRFFLNCSFALLAPTGIGKTSFGLSVASYLTQKNKKSYIILPTKLLVNQTVKKLTQIFKLKEDQILFFGEENKKEKEAKLERLKDGDFSVLITTSMFLYKNHDKIPKDFSLVFVDDVDSFLKTAKNIDKALYLLGFDEKDINLALEVIKLKAKQNKTDEDWNKINQLTEKLRKIEAKRKGVLIVSSATSNPKSNRIKLFRELLGFEVGTPTFYLRNIVDSYDDIENHELSELIKKLGKGGLVFIPSDKKKEYVEEVKEYLTKKGVKAATYEEIDDEILKKYENGKIDVLIGISSYRNPLARGIDLPHVIRYAIFYGVPKIVLSLKFEANLSHLLWALSSIRAYILKKFPQYAIQIDKWITQLKKYQYLTEEFLQNNPNLKEKVDNLRLEVGQFLNSEEIINLLKESNEVTLRKDEDGYKLVVSDVTGYLQASGRTSRMYSGGITKGLSVILIDDKKAFNHLQKRVRWFSDDIEFVDFKSIDLAKILKEIDSDREKVRKILKGEIKFEKVESILKPVLIVVESPNKARTIANFFGKAVRRRVNDHEILETSIDDRYLMITASLGHILDLNKELGYYGVFVKDHIVPVYESIEGKEEIIESIRSVSFESLEVYVASDPDTEGEKIGWDVELLLKPYVKNIQRMEFHEVTKKAIINAIKNPRDFDENLVKAQIVRRVADRWVGFEYSQLLQKAFGKNWLSAGRVQTPVLGWIIEREKERKQKIYRITITLQQDSKKLELDIDYQNKQDAENIFNNLNNIEIIVKEVKEEDKNPLPPYRTDTMLKDASDRYRFSLPKTMELAQDLFELGYITYHRTDSTRVSDVGIALAREYIEEAFGKDYFQARVWGEGGAHECIRPTRAMETEELKSMILSGQYEGLTFDHIKLYDLIFKRFIASQMRAVKFKAKDVIIKGFGFELEKVLHTDIIQDGWNKILPAELHPDLEGIIDISNNKQFKIMPKAFPFTHGELVFRMKERGIGRPSTYATIIAKLLERKYVIEKKGLLFPTSMGIKVYQYLNSLKHVREFLSEEFTRKLEELMDEVEIGEKDYQAILFELFEKIKIRRDN
(1607) Reverse gyrase [Methanocaldococcus fervens AG86]
6
MLVLLMIPMIYKEMCPNCNGEITSKRLEIGVCEKCLKEEKAFEKLKLCEKLREEKTLKNLKNYCNIWNEFKEFEEFVKDLGFELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGILMSLFLSKKGKKCYIILPTTLLVKQTYEKMISLIEKNNLNVKVVAYHSELSTKEKKEAKERIDNNDYDILITTSNFLAKNMPNNVFDFIFVDDVDALLKASKNIDRTLKLLGFDDEIINEAYKIIYLIKIGKIESALKKREFLKKKISKINHGCLIIASATGKSYGDRVKLYRELLDFEIGFGMNKLRDVADIYDEEFSKEKILEYVKLFGSGGIVFVSIDYGVEKAQEIEKFLLKNNIKAKLIHSKDKKGFDDFRNGEIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRLKEYINSLKEKGELKEDIDIEGKTEEEIREIIVEKLKIKNFSLRKEDGEYLLLIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDEKEIFEALKKYMLFMYESEFRKIDEINLEELIKKIDEDREKIKLGRAKGKVPDLLKSVLMVVESPNKARTIANFFGKPSVRKINNRNIYEVCIGDLNLIITASGGHVFDLVTKEGFYGIKIDNNLYIPIYASIKKVNGEQFTDQKNFEKLIKQLMERGERVNAMDAKENIEIIREIADEVDAIFIATDIDTEGEKIGYDIALNALPFNKNIYRVGFNEITKRAILKAVESFKKGEELSLDENKVKGQIVRRIEDRWIGFRLSQKLWEVFNKNYLSAGRVQTPVLGWIIERYNEHKIKVPYLSLRLENDIYVGKIWEEEFNKDEVEVEVNIYDKEISPLPPFTTDTLLEEATKRFGLSADEVMAIAQELFELGLTTYHRTSSTRVSLDGMRVAKEYLKLNNLEDYLKNREYFMEGAHECIRPTKPMDTEELIEFLKESNIKLTKNHIKVYDLIFRRFLASQMKEAVVEYEEIYIKDLDEKIEGYIDVKFDGWSKIYNLKLKKLPKVEKNSLKILEKKITKIPKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVTKSKNKGKLIPTKLGTEVYNYLINNYPNLISEERTRELEEIMDKIENGEVDYLEVLKALHEEILSIK
(1634) Reverse gyrase [Thermoanaerobacter tengcongensis MB4]
6
MALATGAKYYHSCINCGGINTDTRNEKGLPCEVCLPFEDGDVLKGLKLNNSLKGYEKYWNLNQQYKEFEEFFFSKINKKPTGYQRFWAKRLLLSKSFTLVAPTGVGKTTFGLISALWIAKKGGKVALVFPTVSLVEQAAKRLIEFSKEDEDVNILFYTSSLKKKEREKFEKNFSEGNYDILVISSQFISKRKEQLSQKVFDLVFVDDVDAVLKSSKNIDTLLNMIGISQKAIDSTLDNLKKGNNSDKIQIEEKAPKGRLIVSSATAKPKGIKPLLFRELLGFEIGRFTTSARNITNVRIKEKSLEKLLYIINLLKDGILLFVPTEEEGKEIANYLEEHGVKLGKTWEDFEKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFSTKLENAPRFILERNFQDYLENNPKLKAYFKDLQRLSTEKLRKSVEKYISPETWEKLIQKNFPTTKFDKEKNLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFEEDDSLFELLKARLLYLTEEEWTEEGEIEHLVKEAEETRKAISTDSSSKDMKSRMIIVESPTKAQTISKFLEKSSTRRYGSLMVHESITQEGILLLTASKGHLYDLETKTGLHGVEINDGRFIPYYNSIKRCSSCGAQFTDELPRCPYCNSDKIDDKKKILEALRDIAMEVDEVIIATDPDVEGEKIGWDISQYIKPVNKNVQRIEMHEITKFGFDKAIRNRRNCDVNLVKSQIVRRIEDRWVGFELSLRLQKNFQNSNLSAGRVQSTVLGWILEKEIEHSKSKKTVTQFTLDNGFKFEVDGKIDVDEVEVEIVEEKEQALSPLPPFNTPSLLTAASQQFKLPVQQIMEILQTLFELGFITYHRTDSTRISSTGQKIARSYLEKIGKITLLSEREWGKEGAHEAIRPVKPISPEELSEFITEKIAAYLSPMHIKVYSLIFNRFMASQMTSPVVINQKILIKNGSFQVEREVPVKLQEEGWNIFNPITVYTPFEEKKYSVVSKRTYTTHTVPLFTQASLIEEMQKRNIGRPSTYAKIVDILFKRKYIIEDVYKRLRTTALGRKVYSYLSERYMNYINEETTRQLEKLMESVETGEKDYQSVLKNLYEELNEILIKN
(1658) Reverse gyrase [Caldicellulosiruptor hydrothermalis 108]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEECLAQEQLNENIFESLKKKGSLKHYQLYWNFQQIYSMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFSALHGKKSALVFPTISLAQQSFERLNQFKSKIQNADAIRILLFNSSMTKSEKEEFEQRFLSQDFEILIVSSQFISKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKNKSNEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFEFFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEYLQTEKLRQLVSKYISYEDYSKIVNKIFSHLKLTDDGKLIIPDVPTYIQGSGRTSRMFGMNLTKGVSILFEEDDTIFESLKSRLMFLLDEEWIDESEVNLESLIMEVEESRKSRNEDFNVNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWIGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSERTFTLLKLENGYSLEIEGEEECERVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISATGQNIARMFLEKVGKKELFLPRSVGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKIEEEGWLEFLPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILQELYNDISVLLNK
(1675) Reverse gyrase [Caldicellulosiruptor obsidiansis OB47]
6
MATGAKYYHSCINCGGINTDTRNENGLPCEQCLSQKQINDIYKSLKKMGTLKDYQLYWNFQQNLNAFKMFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANTVKILLFNSLMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRTKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLAENGIKIGTTWSNFDEEFELFKEEKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPRFRFSVDMDKAPRFVLERVFVEYLEDHPKLKEYFKNVEILQTEKLRQLVLKYISAESYNKIVQEIFSHLKITDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKESRKIQNNDFYQIDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIEDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNINLVKSQIVRRIEDRWVGFELSSKLQENFQSYNLSAGRVQSTILGWIVEREKEYAKSERTFTMLKLENGYNLEIEGEEECKRVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKEFFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIRVYQLIFNRFMSSQMKNPKVLFQKVCFKIADKEIVKDIPVKIEEEGWLHFLSMQIYPLFENKDYSVTDRRSYKKHTIQLYTQSSLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILQELYNDISELLNK
(1683) Reverse gyrase [Ignicoccus hospitalis KIN4/I]
6
MIEAVYQRSCPSCGGDVERERLLAGLPCSKCSEPRGLLAWKEVLEEEYEAFANFFKKAYGFELWGPQRAWAKLALSGSDAVLLAPTGTGKSTFLAALSSFLKRKGKRVLYVVPSKSLEEQVKERLAEEVDVITMRRLVRDPRAYRGYDVYIFDDVDSVMKSPKSATALIIALGLEEAVPIVNEMVDIIKKGLSDEGRRGRYEELKGELERLKDKKGSQVIMASATAGGGSLTAKLILSLLGLSPASAPPAIRYVDDVKMFHEDPVEGAAEVVRYFTSEGLKGIVFVHEGFPIEEVERALRERGVAAEVVKSGKLKALKKLEKGELDAVVAYSSRYGVAARGIDMPDVIRFAVFVRPPFKKFDLERGLNNPLTLLRVMKKLEMKEDTVKLFKMLSKLSEVELALLRRAMEEGGELEGFLGDALSALKEMKGKVLERLKGEKVVDKGFVVKDGKVFLLDPKTYLQASGRTSRLTPKGMTHGVSVVVYDDEDLMKAFEESLKDRVEFKEELVTPKGPKPVKAKNVLIVVESPTKAKTFARIMGGGGKVEVGGVAAHLAVHEFGGEALFAFIVATKGHLFDVTLDEVGTYGVELGEPVRVYYAPINRCRRCNLAWASSDPRCPKCGLPAESSSKVVEALRRLATVVDEVYLATDPDEEGEKIAWDVMAMIYPFNSNIKRMKYYEVTLRGLHEALSFLTTVDEGTVRSQIVRRLDDRLVGFAVSERLKAAFGDPNHGLGRVQGPVLKFVVERAKARKASAGYSVTLHLSNGDTLRLFVKTKEEALKLASVEEVKILKVEEEVEELKPLPPYTTDTMLEDASKLGLDPSRAMRVAQDLFEMGFITYHRTDSTRVSDAGIAVAREWITSKFEGLFAPRRWGEGGAHEAIRPTRPLSAEDLKLDFALNGMSFEALRLYDMIFRRFMASQMKEAKVRKVKVVYEVAGKRVESAWVAEILEPGWTSVWNIKTKDIKLEKVAKVVSSEVRRASLVQLPKVFEVIRWMKERGVGRPSTYAKTVENLRRHGYVVITPNNYVVSTKKGVAVAEYVERNFPELAEAEYTRRLEEAMELAKSDFWGAFNNTLRAFRALASLES
(1685) Reverse gyrase [Thermocrinis albus DSM 14484]
6
MIGAVFKNLCPNCGGDIGADRLQRGLPCERCMPQEGDPCHLLTEGQLRIWCDVEKKEEDWEKHFERCVGSKPWSLQKTWAKRVFMGHSFALLAPTGVGKTSFGLAMASFLAKEGKRSYIILPTRILVEQVVHKLQERFRLKEEDLLYFGDDSKKQKEEKRERLKEGRFKVLVTTSMFLYRNYQDIPSGFSFIFVDDVDSFLKTAKNVDKALYLLGFSEEDIDLAMRVIQLKTKRQKTDEDWEKIKEISQKLMEKRGEGVLVVSSATSNPRSNRVKLFRELLGFEVGTPTFYLRNVVDAYQEGTHNFLDWVKRLGGGGLLFVSSDKGKEEVDRVVNILRGEGISAVSYEELKEETLKDFEEGKIQLLVGIASYRNPLARGLDLPHVIRYALFLGVPKIVISLKFETNLSHLLWALSSIRSYIVKKLPQHMQKVDNWISQLRRYQYLTEEFVEERPDLKERLDQLRSQIGEFLSSEELVRIMSESEEITLRKTEEGYQLVVSDATGYLQASGRTSRMYAGGVTKGFSLIFVDDKKAFHHLVKKVRWFSDDINFLPVEGLDVEKIMEEVDADRSNVRAFMKGDVSVSSSDLLKPVLIVVESPNKARTIANFFGKAVRRRVGQHDLLETSVEDRYLMITASLGHVLDLVKEGGFHGVLMEKGVTPMYEVIEGKEYVVESLRRMASESMEVLIATDPDTEGEKIGWDLMQLLKPYNHSIRRMEFHEVTKKAILRALKEPRDINENLVKAQIVRRVSDRWVGFEFSQILQQAFGKSWLSAGRVQTPVLGWIIEREKEYRQKIYKVQVLIRDEKGRLKLELDFEDRKTAEAFFKELSYIEVTVKDQKEELRNPPPPFRTDTLLKEASDRYRFSLPKTMALAQTLFELGFITYHRTDSVRVSDYGMSIAREYIEEELGKEYVHTRQWGEGGAHECIRPTRPLEPEELRSMVLSGQVEGLTKEHILLYELIFRRFMASQTRAVKVKVKDVVIKALDRSVELSLVTDVLQDGWNKFLDLELNPDIPPRLDVRELKQMKKQPKAYLYTHGELVQEMKRRGIGRPSTYATIVEKLLERGYVIEKRGFLIPTKLGKKVYEYLRKREEIKAFLSEDFTRRLEEVMDRVEEGKADYEEVLKGLYRDIIKVEAIMEVTR
(1701) Reverse gyrase [Sulfolobus islandicus Y.N.15.51]
6
MINVMYKNSCPNCGGDISADRLLNGLPCETCLPYINGIDGVDIISKVKALYNILLNNDKIKNYWNLYYNITTFEIVFKYFKDKTGYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFIGQDVVYIVPTKSLMEQVCKRLEKLGAQVSCGKVDQRKVSVITISYLNKNANSITSYKPNFVAIDDADAVIKSGKTTGRLVSLLGIPNDVYESAIQLIRLRNKYYFSNEFTEEIKEKIRELELKIAEFKDKISQLVIASATIRPKGIKQKALRLLTGFEPSSIQLYARNIIDTYTDNLDLSIVKELGSGGLILVSKEYGRSRLNEIKKYVEDLGFNAKLAISGRKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFDALSNPFTLLRVGKMIGVNFSELQNKILVLSPSETQLLKFSIIKGETINYQKLDQLRQELLYYISLVKDKLKEIGEETLISDNFVITKQNTNYYIIYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDKHIFEILKKKMQKLFPNTNFTSLSNINLSEIKTKLEESRKEEGNRVHFNISTGLLIVESPTKAKTIAKMFSRPSVRVINKVPVYETIIVDGNQIYVLDVVASKGHIVDLTLEDIGYYGIKVEDSGIIKPYYDLIKKCLDCNKTFSITSDKCPYCGSTNVQTAQTTINLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVYRITYHEITKKAILEALRNPMKINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVDKTMKYKSSMGYVVYIDIAGYSIKMYFSERKKMEEYINNLQVVKIEKISEEKILLSPLPPFTTDTLLIEANMKYKLSANLVMKIAQDLFEAGLITYHRTDSTHISSVGIEIAKEYLQKQGLIKDFVPKSWESSEEGAHEAIRPTRAMDVNELIQEIEENPYKYSIRFSKLHFLIYDLIFRRFMASQMSHAVGTKSRYLIKLNKDDNINTELLSNAEGGFIKVYPVKVYNLPLGEVKPKVNTGKGSSEQLLSYSDVISLMKSKGIGRPSTYAKTIENLVRHGYIVSSKRKSYLIATNRGISAYQFLSSKFYDLVSEGTTAKLMSKLDDIALSKLSASTVLLEIFSEISTLVNPLKSEQNV
(1720) Reverse gyrase [Staphylothermus hellenicus DSM 12710]
6
MEKILDPIYKNLCPTCSGDVFANSLWDFGVCGKCSGETRNSFNALTLYRAFKEDLEDFTSFFRKATGNLKPWGAQLTWVKRLLNGENTVIVAPTGMGKTTLLVVYSVYVAKNYGKKVLFFAPTRALAKQIYNRIIEAAENVCGTCINILFYDSGLSKKRREEILLKIKNNEYDILVLTNHFLNRHYDLIDPSHIGLIVIDDVDSLMRSSKNILRLMKLLGFHEELIEKAKKRNSIIWKLMLSKSLNKEEDYRRYIEELIEIEAEIDKLLRNTSRKQVVIASATGRMKGTYAKVMRDLLRIDVSGITVYGRNITDTYLLINDYVSDADNIIEVIKILGPGALIFISPRHPLKKKLLELVKLLREKLEERGYRVAEANPSTIKKFIRGEYDFLIGSSSYYGVSVRGIDAPETIKYVLFIGTPLFTVELGSFLASPNMLIRVSLMLSEVLGDQRYRGMASAIRRLVFPLNSGEIKLLSMLLKNKITINDLGKDSRVAKVYEQILGFYNEIRKSLEELLSKKKVVNMNTITFYHADNKFYALIPDVMTYIQASGRCSRLYLGRMTHGLSLVVEYEFLSNLVNGLSLKMNMFSHGFVFKDISNVDLYGERKLIEKTRRELKGPVLTYRNILVVVESPTKAKTIARFFGKPVRRKIGSISVYEIPFVKDSEVIHLNIVATRGHLFDLTTDPSIPNHGVLIEDHRISPVYTSIKRCRICGHQFTYGDRCPRCGSTSFTDSYEVVNVLRKLAQEADEVYIATDPDIEGEKIAYDVYLTIKGFVDKVWRIELHEITLNEFLNALENKRDINRKLVEAEIYRRVLDRIIGFSLSQELWRKYSKKWLGAGRVQTPVLGWIIDHYNEYVSNKCRKIIYITEHKGFKFSICIDLKDKDLYKEMRSVDHVTLVLKNSRIETFNPPPPYTTDELLYDASRIGIPSSLTMKIAQELFESGLITYHRTSYHYVSSAGISVASKYLENKDLMKHFHPSHWGNKGAHEAIRPVHPLDREDLEKAVVEGIVAPTIPLTWLHYRVYDLIFKRFISSQMNPYKALIGEYDVVINNKVVKTLVLPIEIVEDGFNIIMGSKTYSFLKGHDRVNISIKDIKAMVTSTKPLCSEGGLVKLMKEHGLGRPSTYSKIISSIVRHGYVIRSKKRGFLIPTKTGIEVYNYLSNSFPELVSIDTTRDMEMRIDLIAKGEMRAADEISRVLDRIRRYKLPLSIREVVAEASA
(1748) Reverse gyrase [Metallosphaera sedula DSM 5348]
6
MITSVFHSSCPNCQGPLEDYRALAGLPCTSCMPGSVDSFKDLPQEEKIKVVYNILVNNGKLGKYWELYYTTEMYNEIINYFKQVTGNEPWSLQRLWLRRLGERENFSLSAPTGMGKTTTLITYSTYLSKGVLYIVPTKSLQEQICSKIGAISSVSCGKVDPNTISVLTVSYVNKNYDHMKDYRPNFIAVDDADAIIKSGKTTDKLVELMGIPKDVYEDAMRLVRLRRMLYLKDNKDEIVEKIALLERKIQSFTGIIAQLVVASATLRPKGVKQKALRHISGFDISTAQTYARNIVDSFTFSSLEEVVQKLGPGGLILVSREYGKEKMKEIKESLTSLNFRVELAVSGRKFLQDFSDGKTDILVGSASYYGVAVRGIDEPKRLKYVLFYGVPKSRTRAEESVKNPFTLLRVSRLLGIQVPEEEILGLSPAEAQAIKIAMITGQSLEGRLGALLEKMKVLVEEAQEALRKVDGTITGETFQISRKGREVFIEYPDIITYLQGSGRSSRLLNGGLTQGLSVILVDDQVIFELFKRKMNFLIPGFAPVNFEALELDRVKEEIERTRREGGNKVEIKTGLLVVESPTKAKTISRLFGFPARRSVGGVPVYETVIVEGNRVYILDVMATKGHVTDLTLEEKGYYGVEIKGDKISPLYSHIYRCASCKRSVSKEVETCPYCGSNLISSSLSTINAMRKLALEVDQIFIATDPDTEGEKIAYDVAVNVSPYNPNIMRIRYHEVTRSGIVEALRSGSTLDMNTVNSQIVRRIEDRWIGFELSKLLKLRFGDRNHGAGRVQTPVLGWIVKRTTEYKQRMGWILNVKVGNYVYREFHREKPNIPDSTVEVEVLEEREETLLPPPPFSTDDLLIDAYRWYRIPAERVMRLAQDLFESGLITYHRTDSHHVSGKGMEIAKEYLEKVNLSQEYQPRGWGNEGTHEAIRPTRPLDVDSLKREIAENPTMLSVKFTWAHFALYDMIFRRFMASQMRESKGTIRKYRMKLGESIWEVELLVRMSGGFSNLYTYRLYDVPVGKVNAEINVVRGSDVKLLTYADVIKDMKEKRIGRPSTYAKTIQSLLRHGYVIESKRKAVLVATKKGINAYEFLSKFPDLTSEEVTADLLSKMDAISSGSLEPTTVLLPVLRELQGLETLPKSEQEI
(1767) Reverse gyrase [Thermofilum pendens Hrk 5]
6
MKALYKSLCPNCHGDISDFRLEKRLPCRQCLPEKDAELFLSSETSRAPDPFFEHLERLVKVLGKSGKLLHLEELYSVERDLADFQAFFRKAVGSRPWSAQKTWARRVLRNTSFVILAPTGVGKTVFGIVMALFLASRGKKSYIVLPTTTLAQQVFEKATLFARKVAVNEGGIVVYHGGLPQSKKEEVLSRVSGGDFSVLITTSQFLSRNFDKLERVRFDFVFVDDVDSIIKSSKNIDRILRLLGFTQDEISVALEIIRERVRLARRLRNGASTSDVYERLEELRRKLAEYTGKGGPRGVLVVSTATGRPRGLRIRLFRELLGFEIGSRGELFRNVVDTYVVVDRDEEVVRQVATLASRLGRGGLVFAPAGTGEEFLESLAEALEKSGLRVGRFYGNHNKRKLLEEFSGGNLDVLVGVASYYGTLVRGLDLPHVVRYAIFAGIPHFKFSIKLEDVPPLRLLQIASNVRVVASRDDQAVIDRLVAYVRNWLQNMEPGEYMALTQCLSEGSCHEKYSRLVESINHLRSIVEKYLSSKEYLERLSKETSLTVVSEDGQLKLLLPDVLTYIQASGRTSRLYARGVSKGLSIVVTGNGLLFEKFAKFSRLYSSDIEWKPLSEVDLDLLVREIDEEREIIRRILSGEVSAELAGDLVKSVLVVVESPTKARTIASFFGKPSRRRVGPLVAYDIAFSGYILTIVATQGHIFDLTTNAYSYNSSKDLYGVLVLDAYGASKHYRFVPVFNTIKRCMNCGAQFTEYAVEDVPRQHVQKVEVEKRCPRCGSTNVFDKAEIVEALRKLASEVEEVFVATDPDTEGEKIAWDVYLSLAPYVRVIKRVEFHEVTRRAFEEALRNPRSINDRMVEAQLVRRIEDRWLGFSLSQKLQECRGHKWLSAGRVQTPVLGWIVENSEKARRKKVVFILELSRRGAEGEKLRVIVDNARLDGQSPAAVSNKIKEEGVTVSIVSREEKTLPPPPPFTTDTLLREANQVLGLDVDRTMRIAQDLFESGLITYHRTDSTRVSDLGISVARTYITERFSEEYFAPRRWGEGGAHECIRPTRPLDVDSLMQMIRQGILQVQVNFTRDHIRLYDLIFRRFIASQMPPAKVVEAKAVVKGPYFEKEITFIESIIEKAEGFTKILPLRTRQIPEGKYDVLLSTYKRVSEVPLYTQADVIRLMKERNIGRPSTYSKIVRTLLDRNYVVEVKGGRLVSTRLGKKVYEFLSVNFGDVVSENKTADVLRRMDEIEEGRADYLDVLAEFYEEVQSKVIEKNADCDILTAPNGKHLEDR
(1812) Reverse gyrase [Acidianus hospitalis W1]
6
MSEELPNLVYMNSCPNCGGEITANRLYKGSACEKCVKEDIQFNSVYDLALYLLKNKNLVNLRSSYEILKELKEVERLFKRVLGSPPLGPQRSWIVRALRGESFAIIAPPGLGKTTFGILMSLYFAEKQRKTLMIFPTKTLVNQVVQRIQEMSKSLEEVPKLAYYYSGITQSQKGELNKILESGDFDIFISTSRYIINNVDYISTKDYKYLFVDDVDSVLKSSKSASAVLKLVGFTEDDIQNVRELLRKSKNSEEVYDEIRKIREKKTGDKIAIFSSATITKGNPVFSALMGFRPGSAVIYLRNVIDSYVQLPSATDEEIIDIVNKIVNKLGSGGLIFVPIDKGVSFANEIASNISGLKAEAISSTSITKLDKFEKGEIDVLVGVATHYGILVRGIDIPWRIRYAIFAGIPRFRFKIGETMHPLAMLKMLTLISLVSKDEEVTKILRIVRNKLRRISPAALVMLANSVKSGKIEDKYIQEAYDLTNKYLRNEEILEKIAEIGEISINNRYISSPDYLTYIQASGRTSRIFGGELTTGLSVLLVDNPRLFELLNRRLSIVLDEVSWNPFDIDNNKIGNNNLHEILKRIDSEREKIRKIKKEGLLTSASVKNIKTVLFIVESPNKAKTISNFFSKPSIRVFNGAIIYETVIGDKVLMVTASGGHVYDLTTKNIGIHGIEVRKNSNLEFIPYYNTIKRCNNGHQFTEYAEGNKCPTCGSTIIKDKIDVINSFRQLALEADEILIGTDPDVEGEKISWDLYLALRPYNPNIKRAEFHEVTRRAIVEAINNSRQFSIPLLQSQVVRRVEDRWIGFSLSTKLQTVFWPQYCSEVLKRTDCGENKNLSAGRVQTPVLGWVINRYNKYNETKRTVFVVKFLNSLSVLVPKQADLDKNDVKVIVYNISKSSETFGPMPPYTTDEMLSDASNLYGISAPEAMRVAQDLFEMGLITYHRTDSTRISNTGIAVAENYLKEILEDKYKEIFKPRTWGEGGAHEAIRPTRPLDENQLRALIEEGELELPKRLTLNHYRIYGLIFSRFISSQIVPLNVDKLKFNIKVLSNGKELKVENPEMDLITNVSLPGGIEVSKLSLYYPRSYFASRDSSYSDTIKKLEECIKSGQCEFTGSIASSFVKSDYQLYTQGELITEMKNKKIGRPSTYATIIATLLKRGYMLESKKVKRLVPSKLGINVYNFLTSKYSKFVSEERTRQLLELMDLIEDGKEDYRQVLKQLYDEIQSIG
(1829) Reverse gyrase [Archaeoglobus profundus DSM 5631]
6
MIPAIYKNLCHVCGNDFDTEEAEKGVCKKKNRIMCRFYEDFIVEEFFKFFEKIVGEPRAIQKFWAKRILRGESFAAVAPTGIGKTTFGSAIALFLALKGRKCYIILPTALLVKQVVENLEKFCEKLDLKAGFNELGDPTILYYHSDIKKDERERFFKLLEEGKFNILVTTAQFLPRYFPQMKHLRFNFIFVDDVDSVLKASKNVDRILQLLGFYYDANEKKWKGKARGCLMVSTATAKKGQKVKLFRELLNFDVGTSTHAVRNIEDVAINSEDINILRQILKKMGTGGLIYARTTEEAEKLYEILKDEFKIGIVTAGRKKDFDLFAEGEIDYLIGTAYYYGTLVRGLDLPERIRFCVFYGAPVFRVRVEDVDTASVGIIKVLAMIFRDNEEVKKFIPYLAVIDKRPEDLEQLKSILKKLIEQGEVKERDIVVRKGEIIFPDIRTYIQGSGRTSRLFAGGITKGASFLMEEDPEIFNAFIERAKFYDIEFKSLEDVDFEKLIKEIDESRERYRRREQFDIIKPTLFIVESPTKARQIARFFGQPSVKVFEENGELQLVAYEVPTPEHVLIVTACIGHVTDLITNMGFHGVITNGKFIPIYASIKRCRDCSYQFTEERDECPRCGSKNVDDSKRRIKALRKLAHDVDLIIIGTDPDSEGEKIAWDLRNLLAGCGEIRRAEFHEVTRRAVVEALKNLRNIDENLVKAQIVRRVEDRWIGFVLSQKLWEVFGDRNLSAGRAQTPVLGWVIQRYEEYKQKKKVAIIRDFDLTLDVEDSKEELELEIELLEEREEERVPLPPYTTDTMLRDANAILKIPAKDAMKLAQDLFESGLCVTPDTYIIMHDGCIKRIDEIFEGEKVLGLNDFHEKDAHVLKFWRIPYKGTIKEITLDNNYRIKATPDHGLFVYRDGKFGWVSAKNIRVGDYVAVAFNTNVERRNDLSLLKLLAELGITDICVEFKENSKLFEKLREKIVGIATSTKYKYLKNRVIPLKYLIEWNVNLQEVEREAKAIYRQRPSAKKIPIFKLNADFWYLVGLVMGDGTVRDGKVAIAQTDVKKVESIVKDILPFIQTWTSGMQVFFANSIIAEILKRLDVRGKLNGLVFSLPEEWINAMIAGYIDTDGCISLMFDKRTGKHNLRIAISSKDREKLEKVGYYLHSIGILNTLHEDKRNGVWTLIVSNRSLKTFKEKIGKYLRIKKERFERAYEVYTNEHKQFESDLVPFGKLFKLLKFKRGIKNKVLKEFGIDVWNWNDCVCIPREKLRKIVELAEDSDIKTFLLELLNANVTWIKVKDVKDRYYNGYVYDVTTTTSNFFANAMLNHNCTYHRTDSTRVSEVGLRIAREFLGDDFVARDWFMEGAHECIRPTRPISKDTLQRLIQEGVIQVEGITSRHLALYDLIFRRFMASQCKPYRVKVARYLIRYDGKEVEEERVLEAEGKAVELYKWCVWVKPALPTGKVKVKAEIRTVPKAPLFTQSDIVRLMKERGIGRPSTYATIVDRLFMRNYVIEKNGRVIPTKRGIDVFNYLASNYGKFVSEERTRLLEEKMDAVERGELDYFKALQELYEEIREIA
(1831) Reverse gyrase 2 [Aeropyrum pernix K1]
6
MPGGVNAVYMGLCYNCGGNIDEDRLEKGLPCARCLPSPPRRATPLTVYRALKKAGTLGAYSWEYLSIREVERFEAYFAAKSGSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYVAAVKRGRVLYLVPTENLVRQVYAKLDQVEPGIATAYYSRMPAKARESSLEKIASGGARLIVATTGFLSRRFDLLHPQYKFDLAIVDDVDSLLRNSRNVERILLLTGFSEETVEAAHSLVKARLKLYRALHSGASESIVSRLEQEIAQLEARLRLSLSEASPGQLVIASATGRPRGVKHLLFKELLGFEVGGGSDYLRNIVDAYVVDSDPVGRTAEIVSALGDGVIVFVSQRLGKDVARAIAGRLEGMGVSTALALTGARRPVEAFARGEARVLIGMASRYGVIVRGLDLPERSKYAVFLGAPSAKTHLLEALYSPRRMLAFLSIAQEKGVEWAGEAFRRLSRLLEKVIDTSIVSLAARGKLEAQGPAGEAAGIISETAPRLVDWLVAEARLQGGLLRVGGLVVDARGPIPYLVVPDAPTYIQASGRVSRLYRGVMTRGLSIVVDEAPEYVEALGERLKWTTSSRLRPLSEVDMEKLRREIEESRRGKGRRVRVKTTLLVVESPTKARTIAWFWGRPGKRRIGRSVIYEASVSDPETGDVHILQITSTRGHLTDLTTDSVGSKYGVDEDGGGYRAYYSTIKRCLDCGAQHTSSSPFCPRCGSPRQVDSKSVVEILRKLASEVDEIVIATDPDREGEKIAWDVFLAVRPYNPNVRRGRFHEVTPRAVIEALRSGESVEKSLIEAQKVRRIVDRWIGFHLSTHLKLKFSKPWLGAGRVQTPVLGWIVDRYREWQDTRGYLVIFKLSSGGRTSYFTQNRLEVENLKRVEWLEVVDIAGKTEERNPPPPYTTDEYLYDASRKLGLSAGLAMKIAQDLFESGLITYHRTDSTRVSPTGVKLALEYLASRGLEGEAQPRGWGEGGAHEAIRPVRPIDAQDLERAVLSGSIRIPIRLTRLHIRVYDMIFRRFIASQMKPATLDIVEATLQAGETVFNHAGVARVRGGYALVNPPRVEEWLARLSPGDRIDVEDVLVVKSSLKRLYRAGDIVKMMREHGIGRPSTYAKAIEQNRRHGYVIESKKMRYLIPTKTGVSIYDYLSNGFKKLVSVDTTRRLEEALERVEKGVEKPEAVLASVWRMVDEAVSLHAATGDVMGQSEA
(1877) Reverse gyrase [Vulcanisaeta moutnovskia 768-28]
6
MEKQPIVIYRKACPNCGGDITSDRLGAGLPCYKCLPEVAKKVANTIEVLNTLEKLGTINRLKSLSNLINEYNEFMNMFKKVVGTNMWGAQRLWTRRLIKGKSFAIVAPTGSGKTTFGMMASLYIALRKRSKVLIVVPTSTLAYDVHRRLSEYSGKMNSNIRIIMASSILYKQELIDAMNAIENGDFDILIITNAFLPRHMDLLRKYRFSLIFVDDVDSVLKASSKNIDRLLLLLGINEEALHKALTVVDLMKKLRKAIRFRASDEEINKLKEDIKKLSTELSNYVKSNNIGILIASGALTRIRRTARLFLFREFLGFETGGRAEGLRNVVDAYTRPKDSLVSAAVEIVKRLGGGGIIYVPPDLREIIDELSEKLNNNGIKAAAYLKPSKSLLNDFVDGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMKFRIKLEEFTPMRYLMFLFNIRNIVPQYLRNDVDRVIARLRNLTALNQEQVNNLLMAIEENRELSGFDKYAADVIKDAVDLVNKLLSDPGIRRAIEQSNEVGLEYRGNDLYVIIPDLTTYIQGSGRTSRLYVGGVSLGLSVLIVDNEKVFNGLVRNLRYRLEDVKVQDINEINIDELMKKIRNERELIRNIMLGRIPNQFLEKDPLRTAFVIVESPTKARTIANFFGVPTRRETGPLVIYEATLGNLYLLITATKGHMWDLIPAAPADVKSFSSFLRSEKLLDYYGILRAGNNFVPIYGTIKRCPVGGETYTEDINVCKIHGAELIDAMDIVNAVRDIATEVDQVMIGTDPDAEGEKIAWDVYMMLRPYVGNIARIEFHEVTKKAIIDAIMNPRTISLSMVGAQLVRRIEDRWIGFGLSQIVQEKFGRRTLSAGRVQTPVLGWIIERYDESRKDKIYTVTMTLSNGIKIRLGIPPDKEELVKTLKALHRNKAVDAVIKVAVTKVGETEEELNPPPPYTTDALLRDSANILGLSVEQTMAIAQELFESGLITYHRTDSTRVSSVGIGIAKEYISEKVSSDYFVGRTWGGKEIGAHECIRPTRPIDSDDLRNLLNTGLLQLAIKVTANHLRVYDLIFKRFIASQMKSAKVMKEKLRISVYFNGVDTHDEEIERISKILEPGFTRFWGYLEGKEYQELTPGEYNVTSIDYIKKVSRTLPLREGDIIAMMKERGIGRPSTYAKIVDVILKRRYALVVGRRTRYVVPTNLGRQVYKFLTEDNKEFSDLVSEERTRMVEKHMDDVEVGERDYMDVLNELFNEAISKGILKENVIS
Taxa distribution
Family tree
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