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Taxon : Thermoprotei
Informations
Name
Thermoprotei
Rank
class
# topoisomerases
73
Lineage and sub-taxa
Lineage
Archaea
>
Crenarchaeota
>
Thermoprotei
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(402) Reverse gyrase 1 [Sulfolobus tokodaii str. 7]
6
MLKVYYTFGCPNCGGPIDDEHLLAGVPCSKCLPGRVENLDYRVIYDLLVKNSTLKGYAEYFYDNETFEEIVRIFKRVIGNEPWNLQKYWIKRLAKSESFSLSAPTGLGKTTTLLVYSLFFSNTTLYVVPTNSLKDQICERLRNMGAKVSCNDVKEEYINVATFNRILRHYDNYVSLQPKLVIVDDSDMILKSGKTTEVMAKILGISEEIFQYAISLIRLKRILKFNEDDKELKNKIVELEYKIGSWKPFVQFLVASATLRPKGIKQQALRTLIGFEPSTIQTYLRNIADLYYQGVDIEAILDKISDNGGLLLVSKEYGREKMLELKEIIEKRGYSTGLAISGRKFLNKFTEGKIDYLIGSASYYGVAVRGLDEPKRLKYVIFYGIPKIRLNLTDALNNPSLIVKIGELLNIDVKDIRRKLLFLSPPEFQILRYSLMKDEELSGKLKDIKVNLINIKEKIWDVLKSDNIKKLKADTFLVTENNGKYYVYIPDTVTYIQASGRSSRIISNGLTFGISIVLVDNIDLLDILSQKLKKIIPNFMFKNINEVDIRELKSLAVSSREVSTSQKKKINIKTILLIVESPTKAKTIARLFGRPSRREVHGIPVYETIILVNDEILITNIIATKGHITDLTTENIGYYGVEVGNNEFNAYYSPIYKCYNCGKTFTIKSNTCPYCGSVFISSSEKVVSALRKLSTEVDEIYIASDPDQEGEKIAYDVAMLISPYNKNIYRIKYHEITRNGILNAILNKGKINMNLVKSQIVRRIEDRWIGFELSLALKSMFYERNHGSGRVQGPVLSWIVERTKEYKKNYGWILYIKLGDYAIKKFFRIKEEANKFIEKLNIKINLISERKEIQNPLPPFTTDSLLMDAYDKLGIGSQIVMKIAQDLFESGLITYHRTDSTHVSALGISIAKEYLESKNLNDSFSGRSWGNEGTHEAIRPTSSMDTESLIKDIEDNPNKYFIKFTKYHLRIYDLIFRRFIASQMKPAEVTYSKFEIFINGEKLEVELPTKISGGFSIIYPLKTYVVSEKYSTYLTKGSIIPLFTYAEIIKNMKEKEIGRPSTYAKTISALIRHGYVVESKRKALLIATNKGIKAYEFLSSCCSDLISENRTKLLLQKIDKIANGDVNVDYVLEDLHKEITQISGKLVNSLKLDTNV
(951) DNA topoisomerase [Sulfolobus tokodaii str. 7]
3
MNCYPKNYILVIAEKSKAAKKIAEALSDKPTTCKKYSVSYWVVNYKGKVNVVAPAAGHLFNLYGDSSFPIFSMDWKPLWEIDDSAKYTKKYYNLLKDLSKYAIEYINACDYDIEGSVIGYMIIKHFGDLKKAKRMKFSALTKQDIQKAYSNLSPLDYNMINAGIARHKVDWIWGINVSRALMLAVSSVTKKRVTLSAGRVQSPTLIHVVENEIARELYIPLPVYRVRVKIKIGNETFSLSLNRTFEYKEEAQEFANKIKKSRAVVDEVRIEEKPLTRPSPFNLGDLQAEAGRILGYSPYYVERLAEELYLDGLISYPRTNSQKIPPSVDIKSIVNGLEANFKNLVGLVRNITKGEYIVRQGSKDDPAHPAIYPTGNRITEKLGIKQYKLFELITRRFLASISRDAIMITQKIIIRFKDVDISDEITRQKIKFKGWLLLYPYHSVKDEELLDVKEGEEVKIESVSVKMDLAKPDVKRYNKVQLLKWMETSNLGTEATRGKIIETLFNRKYLSQKRGTIYPTSLGIVIVEVLKDYFKDLTSIELTSKMEEKLNEILDGKETVEGVVAETINTLRIYLDNYNKYKDQIGIKLAKILGLMKYKKCKFCDLEAEYDNLCKYHYNAYMKLKETLKVWKERTKLEDKDILKKIYSSKTTGKYIKDMISEMM
(1877) Reverse gyrase [Vulcanisaeta moutnovskia 768-28]
6
MEKQPIVIYRKACPNCGGDITSDRLGAGLPCYKCLPEVAKKVANTIEVLNTLEKLGTINRLKSLSNLINEYNEFMNMFKKVVGTNMWGAQRLWTRRLIKGKSFAIVAPTGSGKTTFGMMASLYIALRKRSKVLIVVPTSTLAYDVHRRLSEYSGKMNSNIRIIMASSILYKQELIDAMNAIENGDFDILIITNAFLPRHMDLLRKYRFSLIFVDDVDSVLKASSKNIDRLLLLLGINEEALHKALTVVDLMKKLRKAIRFRASDEEINKLKEDIKKLSTELSNYVKSNNIGILIASGALTRIRRTARLFLFREFLGFETGGRAEGLRNVVDAYTRPKDSLVSAAVEIVKRLGGGGIIYVPPDLREIIDELSEKLNNNGIKAAAYLKPSKSLLNDFVDGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMKFRIKLEEFTPMRYLMFLFNIRNIVPQYLRNDVDRVIARLRNLTALNQEQVNNLLMAIEENRELSGFDKYAADVIKDAVDLVNKLLSDPGIRRAIEQSNEVGLEYRGNDLYVIIPDLTTYIQGSGRTSRLYVGGVSLGLSVLIVDNEKVFNGLVRNLRYRLEDVKVQDINEINIDELMKKIRNERELIRNIMLGRIPNQFLEKDPLRTAFVIVESPTKARTIANFFGVPTRRETGPLVIYEATLGNLYLLITATKGHMWDLIPAAPADVKSFSSFLRSEKLLDYYGILRAGNNFVPIYGTIKRCPVGGETYTEDINVCKIHGAELIDAMDIVNAVRDIATEVDQVMIGTDPDAEGEKIAWDVYMMLRPYVGNIARIEFHEVTKKAIIDAIMNPRTISLSMVGAQLVRRIEDRWIGFGLSQIVQEKFGRRTLSAGRVQTPVLGWIIERYDESRKDKIYTVTMTLSNGIKIRLGIPPDKEELVKTLKALHRNKAVDAVIKVAVTKVGETEEELNPPPPYTTDALLRDSANILGLSVEQTMAIAQELFESGLITYHRTDSTRVSSVGIGIAKEYISEKVSSDYFVGRTWGGKEIGAHECIRPTRPIDSDDLRNLLNTGLLQLAIKVTANHLRVYDLIFKRFIASQMKSAKVMKEKLRISVYFNGVDTHDEEIERISKILEPGFTRFWGYLEGKEYQELTPGEYNVTSIDYIKKVSRTLPLREGDIIAMMKERGIGRPSTYAKIVDVILKRRYALVVGRRTRYVVPTNLGRQVYKFLTEDNKEFSDLVSEERTRMVEKHMDDVEVGERDYMDVLNELFNEAISKGILKENVIS
(322) DNA topoisomerase [Vulcanisaeta moutnovskia 768-28]
3
MIIDSLVVAEKDSVARAIAKYLAQGSISIRRIYGIKAYWFTRDNRQWVSIGLKGHIMNVDFSEELNKWHSVEPSKLFDVEPILVIRGDDLNYVRALTHLGASANTVYLALDADPEGEAIAYEAMFVIRNVNPGAVFKRVLFSAVTRNAIIEAFNSPTNLNPGLAKRVFTRMVLDLTLGAVFTRALTLSVEKIDRKALSRGSFLSYGPCQTPVLNLVVQRALERENFKPEKYYTLHIIVDADGKRIMLDHDGVFKDRQEAEKILNLVRSMAKAKVIIASYKEDFLGPPVPLDTIELERRASRFLNIRPKAALDIAEELYRHGYISYPRTETTIYPPTLSLKQVLLELTHGEHGDYAKTLLGMTIKPTRGNSNDGAHPPIYPTRGVSRQELLRYFKNERYWKIYDLVVRHFMATLSPPARIERQRIVVEVVDHRFSTDGLRMIDKGYLVIYPFESPSEKVLPRVKLGDELSIIKAWVEERETEPPPYLSESELLRLMRKYGIGTDATMQDHIHTNIIRGYFRVRNKQCIPTPLGKAVINVFSKTGGELIDPWFRSRMEKALMEITSGSLRPTDVLFTFKSEARKIYEKFMNRQNEVAMELIKALKESLSKTNRNSNRKVS
(863) Reverse gyrase [Pyrobaculum aerophilum str. IM2]
6
MEVPLVAYLHSCPNCGGPITSDRLASGLPCRECLPDGAKAGSIKQVITALRKRKALQGLAWVEAYLRGYEEFAEFFKRIVGFEMWGAQRLWARRFVRGKSFAIVAPTGSGKTTFILIATLYSAKQGKRALLIFPTSALAHQAYKKLLTFAERGGVSLKALAYHSLLTEREKKEALEALERGDFDVLVTTSAFLPKRFELLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDAVLNTALEVINLTKQLRKAEVAGDLKEVERLDQEMAKLRAKLREEVQRLKLGVFVASGALAKARRTVRLLLFREILGFDVGGRAEGLRNVVDLYVEASDNVIEQTLALVKRLGPGGIIYVQDRELGEAIVERAREAGLAVEHFFRPRRGVLESFERGELAALVGLASSRSALVRGIDLPHVIRYVIFVGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLAGDARYKADRLIGQLKRLAPYALSVQEALKKASEGAELSSFDRHAVDVVKSAVEFVNSLLQNEEIRKAIETSSEVKLAYIDGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDPKVFHALKRELSLRFDEAEFKHLGEADLDKILADVDRDRKTIRDIMEGRLVPAARGVDLMRTILMVVESPTKARTIANFFGRPSLIISEGIPIYEVSTGDAVLMVTASLGHIYELPTSLNKIDQRQREVLAKWFGDFKHGNYDGENYAVIVKEYGFVPVYNKIWRCRGAVYVDDIDIPPGCKPLDVLEAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVQDIRRVEFHEVTRRAILNALANPRGVNFSLVKAQIVRRVEDRWIGFGLSKILQANFKNPNLSAGRVQTPVLGWIVNTYEESLKNRVYNVELQLNDVDIRLQVPRDVLDVLRKKKRVAIKLVARERRQVNPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGIAIAREYIVRKFGEGVFKPRSWGEAEEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQLTKSHYQLYDIIFRRFMASQMEPSVVEVAKYNVEIDGHVIQLERTVGVAYMGFQTLYQLTPVEPELPTGTLDVVIKRYRVVRRVLSQADVLALMRQRGIGRPSTYAHILQVLAKRYYVYVTGRTKLMIPTKRGREIFRFLKEAFGKLVSEDRTRLIEQYMDAIEVGKARYEEVIAELYDEFRKEVLPHLAS
(207) DNA topoisomerase (TopA) [Pyrobaculum aerophilum str. IM2]
3
MKLIVAEKRSVAQSIAKFLGRSYKSQKLYGVSVYRFNYGGGEAVAIGLSGHIMDFDFAARQNVWTWLPPEELFNATPILVLRGETLKYVKALKSLATKADEVYLALDADVEGEAIAYETALVVKMVNPRARLYRVRFNAVTYKEIVSAFQKPTYIDLKKVEKVFTRMQVDLTLGAVFTRFLTLTVRNSLNKGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKAVVEIGSSKVEMSADAKFKTKGEAEAIAATIKRGVVKIAVYKPHYVEPPEPLETVELERRASRWLGINSKKTLDIAEELYRAGYISYPRTETTIYPPTLDLKEVLEELTAGEHGPYALELLRKGFKPTRGDSDDGAHPPIYPTKGATRAEIFKVFGKAGGHAWAVYDLVVRHFLATLSPPALVEKQKIVVSFGKIELSAEGQRTIDEGYWRIYPWERQPEKPLPRVAPGEPARAVEIRVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIYTNIKRGYVKLVKGKCIPTALGISLATSLFQYAPELIEPTVRAKIEKSLNSIVKDGVSPAKLIAEIKLEFSKYYQNLKAKREEIKKALETALYSIQQQSRG
(898) DNA topoisomerase [Pyrobaculum calidifontis JCM 11548]
3
MKLIVAEKRSVAKAIAQFLGGSYRAQRVYGVPAYFFNYGGEAVSLGLMGHIMDFDFAARENVWTWIPPEQLFHATPLLVIRDEAAQYVKALQSLARRADEVYLALDADVEGEAIAYEAAIAVRAVNRRARLYRVKFNAVTPKDIRAAFQKPDTLNLKLVEKVFTRMQIDLTLGAVFTRALTLSVRNSLEKGQFLSYGPCQTPVLGIVVNRELERINFKPEKYYVIKAVVDIGGHRVEMGSEVRYKTRAEAEAAASLIKRGVVKAAVYRPHKVEPPEPLETVELERRASRWLGINSKKTLDVAEELYRAGYISYPRTETTIYPPSLDLREVLQELAKGEHGEYARGLLKAGFRPTRGDSDDGAHPPIYPTKGATKDELYRRFGKAAAYAWPIYDFVVRHFLATLSPPAVVEKQKIVVSFGKIELEAEGQRTLDEGYWRIYPWERQAEKPLPVVKPGEAAYAVKVSVVERETQPPPPMTESELLALMKKYGIGTDATMQDHIHTNVKRGYMRLQKGKCTPTPLGMALATALFQYVPELIEPTVRAKIERALNSIVRDGVPPAKLAAEVKAEFAKYFEKLQQHRREIKEALEKALNSSP
(632) Reverse gyrase [Pyrobaculum calidifontis JCM 11548]
6
MDIPLVVYLHSCPNCGGPVTSDRLAGGLPCRECLPEVVKAGGIADVVRALRRRRALKGLAWVDEYLRRYEEFSSLFKAAVGFEMWGAQRLWARRFVRGRSFAIVAPTGSGKTTFILVATLYAAREGKRALLIFPTSALARQVHQRLLSYAEKAGVSVRAVAYHSLLTEKEKKEALGAVEGGDFDVLIVTSAFLPRYFDLLKRFKFDFVAADDVDSILRATSKNIDRILRLLGVSDEVLKLALDVINAVKELRKAEIAGDLKEVERLDAEVTALRAKLQEEARRLKLGIFVASGALARARRTTRLLLFREILGFDVGGRAEGLRNVVDVYVEQGKDVVGQVVELLKRLGPGGIVYVQDRELGLAIVERAVGESLAVEHFLRPRRGVLERFERGELAALVGLASARSALVRGIDLPHVIRYVVFVGVPKYKFRVRLEEFSIPAYLTFFYNVRAVLSGELRYKVDRAIGQLKRLAPYALSVQEALKKAAEGQELSSFEKHAVDVAKGAVELANSILSDEELRRAIDSSTEVRLAYIGGELYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVVDDWKVFTALQRELKLRFDEAEFKRLDEVDLSAVLAEVDRDRRTIREIMEGKAVVTGGRELMRTLLMVVESPTKARTIANFFGRPSMLLVDGVPVYEVSTGDAVLMVTASLGHIYELPTSLDRISKEEREVLRRWFGDFRRGDYDGGEYAVLATEGGFVPVYNKIWRCRGAVYVDDVDVPPDCRPLDVLAAIRNLAVEVDAVLIGTDPDSEGEKIAFDLYLGLRPYVADIRRVEFHEVTRRAIISALANPRGIDYSRVKAQIIRRIEDRWIGFGLSKILQREFGSPNLSAGRVQTPVLGWVVTTYEESLRQRMYNVELQLDDVDLRLQLPQEALKALRERRRVAIRKAGAETRVVNPPPPYTTDELLRDAVNRLGLSADYAMRIAQDLFESGLITYHRTDSTRVSAAGIAVAREYITKRFGEGAFRPRTWGEEAEGAHEAIRPTRPIDVEELRGLVNAGVLQLAIRLTRSHYQLYDLVFRRFMASQMEPSEVEVERYEVEIDGYVAQVERVVDIKRQGFQVMYQVTAVEPGLPTGTIEVTVKRYRVIRRILSEADVLALMRQRGIGRPSTYARILQVLAKRYYVYVAGRRRLMVPTKRGIEVYHYLEQKFGKLVSEDRTRLIEQHMDAVEQGKAKFEEVLGELFDEFKTEVLPNLSGASPKS
(471) Reverse gyrase [Vulcanisaeta distributa DSM 14429]
6
MEKQPLVIYRRACPNCGGDITSDRLASGLPCHRCLPDVPKKVASTIEVLNMLEKLGTINRLRSLANLVNEYNEFADMFRKIIGTNMWGAQRLWARRIIKGKSFAIVAPTGSGKTTFGMIASLYVALKRRGRVLIVVPTSTLAYDVHRRLSDYVNKMGVNVRIVMASSILSKQELTEAMKTIEDGNFDILIVTNAFLPRHMDLLSRYRFSLIFVDDVDSVLKASSKNIDRLLLLLGINEEALRKALTVVDLMKKLRKAIRFRASEEEINKIREDIKRLNAELTNYIKSNNIGILIASGALTRMRRTARLFLFREFLGFETGGRAEGLRNVVDVYVRPRDSLISTAVDIVKRLGSGGIIYVPPDLRDIVDELLEALNKNGVKAASYLKPSKSLLNDFVEGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMRFRLRLEEFTPIRYLMFLFTIRNVVPQYLRNDIDRVVARLRNLTALNQEQINNLLKAIEENKELSGFDKYAADVIKEAVDLVNKLLSDPNIRKAIEQSNEVGLEYRGGELYVIIPDVTTYIQGSGRTSRLYVGGVSQGLSVLIVDNEKVFNGLIRNLRYRLEDVKIQDINEVNIDDLMKRIRSERDLIRNIMLGKIPNQFLEKDPLRTAFVIVESPTKARTIASFFGVPTRRNVGPLIIYEATLGNLYLLITATKGHMWDLIPAGPADVKELAPALRAGKIIDYYGILKTGNNFVPIYGTIKRCPVGGETYTEDVDVCKIHGVKLVDAMDIVNAIRDIATEVDQVMIGTDPDAEGEKIAWDVYMMLRPYVSNIVRIEFHEVTKKAIIDAITNPRAISLSMVGAQLVRRIEDRWIGFGLSQIVQEKFGRRTLSAGRVQTPVLGWIIERYDESRRDKVYSVTMTLSNGVKVRLNIPPDKEELIKALKAMHRNKSTDVEVKVRVTKVGEEEEELNPAPPYTTDALLRDSANILGLSVEQTMAIAQELFESGLITYHRTDSTRVSTVGIGIAKEYISERVGADYFVGRAWGGKEIGAHECIRPTRPIDSDDLRNLINTGLLQLAIRVTANHLKVYDLIFRRFMASQMRSARVLKEKLRISIYLNGANVHEEEVERVSKILEPGFTKVWGYIEGREYQELMPGEYGITSIDYIKKVSRTPPLREGDIIAMMKERGIGRPSTYAKIVDVILKRRYALVVGRRTRYVVPTNLGRQVYKFLTEENKEFSDLVSEERTRIVERHMDDVEVGERDYMDVLNELFNEAVSKGILKENVIT
(1660) DNA topoisomerase [Vulcanisaeta distributa DSM 14429]
3
MIIDSLVVAEKDSVAKAIAKYLAQGSISVKKVYGVKSYWFTRGGRQWVSIGLKGHMMDVDFPEELNKWHSVEPSKLFDAEPILVIREDTISYVRALSRLGASASVVYLALDADSEGEAIAYEAMLVIRNANPRAVFKRVLFSAVTKSDIIEAFNSPTSLNPGLAKRVFTRMILDLTLGAVFTRALTLSVEKTDKNALARGSFLSYGPCQTPVLNLVVQRALERENFKPEKYYTLHIIVNVNGVRVTLNHDGTFKDKQEAERVLSLVRGKARAMVIIANYKEDFIEPPVPLDTIELERRASRFLNIRPKAALDIAEELYRHGYISYPRTETTIYPPTLSLRQILLELTHGEHGDYAKTLLGMSIKPTHGDSNDGAHPPIYPTRGVTRQEILRYFKNEKYWKIYDLVVRHFLATLSPPARVERQKIVVEISGHRFSVDGLKIIDKGYLTIYPFESPSEKVLPRVRVSDELSIVKAWIEERETEPPPYLSESELLRLMKKYGIGTDATMQDHIHTNVIRGYFKIRNKQCIPTPLGKAVISVLSKTGNELIDPLFRSRMEKALMEITSGSLKPDDVLFTFKNEARKIYEKFINRQREVAMELIKALKDSLSKGNKGAGGKAS
(165) DNA topoisomerase [Thermofilum pendens Hrk 5]
3
MSYKAVIVAEKNSVARAIASFLGGSSVRRFRVERVPAYEFLWEGGKHLSIGVSGHILDFDFPEEYNKWESVDPRVLFFTNPVLVTREGAYIYVRALKTLARQTSTVILALDADVEGEAIAFEVMRIMKSVNPELEFRRAWFSAVTKSDILEAFRKLREPNENLANKAFARMVVDLTIGASFTRILTLSARRNGGVMPRGSFLSYGPCQTPVLYLVVKRELEREQFKKKKYYVLRVRFRSQEGVFTASATFEDQEKAKSALDSVKRTGVGVVVSAEFNAVEVEPPVPLNTVYLESRASLFLNLRPKETLSIAEKLYSFGYISYPRTETTIYPPTLNLRGIASMFTRWEDAGWYVAKVLAKGFTPTRGREDDKAHPPIYPTRSASREEITRRFGEKAWKVYEYVVRHFLATISENAVVERQRVVVKVGELSLQSEGRKLVYAGFYNVYKYSVPKDEPLPYVVEGEEVEVEDAKIEARTTQPPPYLSESELLALMKKYGIGTDATMQEHIHTNIERRYFVVKNKRCIPTPLGRTLALALYETVPELVLPEVRGKMEASLSKIATGERTPEEVVNEMRSEFLEYYDRLVERIDYVSKKIVEGLKMVFQDEKQQARAGSVGEERSRSTRTHRKGKK
(1767) Reverse gyrase [Thermofilum pendens Hrk 5]
6
MKALYKSLCPNCHGDISDFRLEKRLPCRQCLPEKDAELFLSSETSRAPDPFFEHLERLVKVLGKSGKLLHLEELYSVERDLADFQAFFRKAVGSRPWSAQKTWARRVLRNTSFVILAPTGVGKTVFGIVMALFLASRGKKSYIVLPTTTLAQQVFEKATLFARKVAVNEGGIVVYHGGLPQSKKEEVLSRVSGGDFSVLITTSQFLSRNFDKLERVRFDFVFVDDVDSIIKSSKNIDRILRLLGFTQDEISVALEIIRERVRLARRLRNGASTSDVYERLEELRRKLAEYTGKGGPRGVLVVSTATGRPRGLRIRLFRELLGFEIGSRGELFRNVVDTYVVVDRDEEVVRQVATLASRLGRGGLVFAPAGTGEEFLESLAEALEKSGLRVGRFYGNHNKRKLLEEFSGGNLDVLVGVASYYGTLVRGLDLPHVVRYAIFAGIPHFKFSIKLEDVPPLRLLQIASNVRVVASRDDQAVIDRLVAYVRNWLQNMEPGEYMALTQCLSEGSCHEKYSRLVESINHLRSIVEKYLSSKEYLERLSKETSLTVVSEDGQLKLLLPDVLTYIQASGRTSRLYARGVSKGLSIVVTGNGLLFEKFAKFSRLYSSDIEWKPLSEVDLDLLVREIDEEREIIRRILSGEVSAELAGDLVKSVLVVVESPTKARTIASFFGKPSRRRVGPLVAYDIAFSGYILTIVATQGHIFDLTTNAYSYNSSKDLYGVLVLDAYGASKHYRFVPVFNTIKRCMNCGAQFTEYAVEDVPRQHVQKVEVEKRCPRCGSTNVFDKAEIVEALRKLASEVEEVFVATDPDTEGEKIAWDVYLSLAPYVRVIKRVEFHEVTRRAFEEALRNPRSINDRMVEAQLVRRIEDRWLGFSLSQKLQECRGHKWLSAGRVQTPVLGWIVENSEKARRKKVVFILELSRRGAEGEKLRVIVDNARLDGQSPAAVSNKIKEEGVTVSIVSREEKTLPPPPPFTTDTLLREANQVLGLDVDRTMRIAQDLFESGLITYHRTDSTRVSDLGISVARTYITERFSEEYFAPRRWGEGGAHECIRPTRPLDVDSLMQMIRQGILQVQVNFTRDHIRLYDLIFRRFIASQMPPAKVVEAKAVVKGPYFEKEITFIESIIEKAEGFTKILPLRTRQIPEGKYDVLLSTYKRVSEVPLYTQADVIRLMKERNIGRPSTYSKIVRTLLDRNYVVEVKGGRLVSTRLGKKVYEFLSVNFGDVVSENKTADVLRRMDEIEEGRADYLDVLAEFYEEVQSKVIEKNADCDILTAPNGKHLEDR
(1325) Reverse gyrase [Thermoproteus uzoniensis 768-20]
6
MDFRVLPALYLHSCPNCGGAVESYRLAEGLPCSECLPEEVAGSDIRRVIENLRRRNALRGLAPLADVLRRYEEIANLFEKVVGFRMWGAQRLWARRLAAGKSFAVVAPTGSGKTTFLLISALYMTSRGKALLVFPTSALAYQAYKKLLDYSSRAGLAPRIVTYNTMLKPQEREEALKRIEAGDFDILVITSAFLPKYFELLARHKFAFVATDDVDSVLRATSKNIERLLKLLGATDEVLGKAFELIELGKKRGKAVLAGDEKEAERIEREIEKAREELRRIKAELRLGVFVASGALAKARRTARLLLFREILGFDVGGRAEGLRNVYDLYVKMAEDPKTQVAELVKRLGGGGIIYVLDKDFGKDLVQHLQASGIKAEHFFRPRRKVLEAFEQGQLSVLVGLASPRSALVRGIDLPHVIRYVVFVGIPKYKFRVKLDEFSVPAFLSFLYNVRAILPQDLRFRADRLIAQLRRIAPYSARLDKILKEGASNSFEEYVLGVAKSAVEFVASLLSRDDIRKAIEASTEIKLTYIGEQLYVLLPDVTTYIQGSGRTSRLYAGGLSRGLSVVLVDDEKVLNALIREMELRFDDVRFEELSKADLDGILKSVDEDRENIRRILSGMLKPEELASRDLMKSILLVVESPTKARTIASFFGRPNMLIIGGMPAYEVSTGDSMLTVIATMGHIYELPTNLQRVAEDERRKIWRLVKPVAAGPYSPMDYSVVKTEAGYVPIYNRIYKCPGSSYVDDLDVPEGCKPLDMISTLRELASEVDAVYLGTDPDSEGEKIAYDVYLILRPYVGLIKRIEFHEVTRRAIMNALASPRDVNLSMVAAQIVRRIEDRWLGFGLSRKVQEAHGLAFLSAGRVQTPVLGWIVERYENSKAERKFDVVLKIGDGQIRLALPEDVYKALKENRKARISLLEEKTETIQPPPPYTTDEYMRDAVNKLGISAEEAMSIAQDLFESGFITYHRTDSTRISTTGIGVAREYVARRHGADAFRPRTWSAGEEGAHEAIRPTRPIDAEELRGLVAAGVIQPTIRLTRNHYAAYDLIFRRFMASQMREAEVVVARYALLLDGFNAEVRRVVEVKNEGFLAEYRSVELEPRLPTGEVDVEIAYAKRLVELLSQADVLRMMRERGIGRPSTYAKILEVLSRRGYVVVRGRRKFMIPTKRGIEIYRYLRENYGKLVSEERTRLIEKYMDDVENGRKNYVAVLDELFTEFLQEVLTRQ
(1621) DNA topoisomerase [Thermoproteus uzoniensis 768-20]
3
MLIVAEKRSVAQAIAKYLGGTYSSFKVSGVSAYRFKYDGASAVSLGLSGHILDFDFPQEMNRWGAVDPARLFDEAVVLTPRPETLKYLYALRSLARGQDVVYLALDADSEGEAIAYEVVLQVRVVNPAARFKRVRFNAVTKAEITRAFARPVDLDLKVVEKVFARMASDLTIGAAFTRLLTLSVRREDSSALPFGKFLSYGPCQTPVLGLVVSRELERLNFKPEEYFVVRAVVGTGGGEVEMRSKPFKRREEAEAALAAARKAEGRIAEARYEKAEVRPPVPLETVELERRASRWLNIRAKAALDIAEELYRLGYISYPRTETTIYPPTLDLRAILEELRNTPFGQYAEDLLRRPFTPTRGRSDDGAHPPIHPTRGAGRGEIEARLGQRGWKIYELVVRHFLATLSPPAVVERQRIAAAFGPLVLEAEGRKVISKGYWTVYPYEEEEEEPLPYVKRGDPAELLSAKIERRLTEPPPRMTESELLKLMRKYGIGTDATMQDHIHTNVLRGYMRIAGGKCIPTPLGMSLATALMKHARPIIDPEVRSKMEAALQEIAAGRMDPSKVVAAIREEFKKYYKFLEDKKAEIAGELVKALKEGPDRKQ
(1125) Reverse gyrase [Thermoproteus tenax Kra 1]
6
MDFKTIRAIYLHSCPNCGGAVDSSRLAQGLPCSECLPRALKLENLKSVIQALKSEGSLKELATLDEVLRRYEELNVLFEKVVGFRMWGAQRLWAKRLAAGKSFAVVAPTGSGKTTFLLVSSLYMARGGKVLLVFPTSALAYQAYKKLLDYSARANYSGRIISYNTMLREQEREEALKRIEEGDFDILIITSAFLPKYFDVLAKYKFIFIATDDVDSVLRATSKNIERLLRLLGATDEALNLALDIIELNKKRARQMLGGDEKGLEESDVEIKRKREELRRLKARLKLGVFIASGALAKARRTTRLLLFRELLGFDVGGRAEGLRNVYDVYAKLSEDPRAQVAALVKRLGSGGIIYVQDKDLGRELVEYLKGEGIKAEHFFRPRRKVLEAFERGELDALVGLASARSALVRGIDMPHVIRYVIFVGIPKFKFRVKLDEFSAPAYLAFLYNVRGVLPQELKFKADRLIAQLRRIAPYTAGLEKVLTEGPKNSFEEYLLNVVKSAVEFVGLILSRDDVKRAIETSTEVKLTYIDGQLYVLLPDVTTYIQGSGRTSRLYAGGLSRGLSVILVDDEKVLHALRRELELRFDEVKFYDLAETDLDKILREVDSDRETIRRILSGSFKPEELSARDIMKSVLLVVESPTKARTIASFFGRPNMLIVGGVPAYEVSTGDMMLTVIATMGHIYELPTSLAKIEPSEKERVLRAVGRTLSEIYSPEDYAVFKTEDGYIPVYNRIYKCPGASYVDDTEVPENCQPLDIISTLRNLASEVDLVLLGTDPDSEGEKIAYDVYLALRPYVGSIKRIEFHEVTRRAIVNALSSPRDVNLPMVAAQMVRRVEDRWIGFGLSRRVQEAHGLAFLSAGRVQSPVLGWIVERYQSSRAERKFDVTIELEDGSIRLTLPEDSYKALKSEGRVRIKRLEGREVVLQPPPPYTTDEYMRDAVNKLGITAEQAMAIAQDLFESGFITYHRTDSTRVSATGIGIAREYISKRFGADLFKARPWATGEEGAHEAIRPTRPIDAEELRGLVAAGVIQPTIRLTRNHYAAYELIFRRFMSSQMREALVRVEKYEVEAGGYKAEVERVVEIKEEGFLRMYRTVEEARPLREGESPIKITYAKRHVELLSQADVLRLMKERGIGRPSTYAKILEVLSKRGYVVVRGRRKFMIPTKRGIEVYQYLKSNFGKLVSEERTRLIERFMDDVENGRRDYRAVLDELFEEFIEEVLKR
(1842) Topoisomerase (DNA) III alpha [Thermoproteus tenax Kra 1]
3
MLIVAEKRSVAQAIAKYLATSYSYFKISGVMAYRFKYKDRQAVSLGLSGHILDFDFPQELNKWNALEPVELFDKITVLVPRDETIKYLYALRALARDEDEVYLALDADSEGEAIAYEVVLQVRAVNPRARFKRVRFNAVTKKDIVQAFERPVELDLKVVEKVFARMVSDLTIGAAFTRLLTLAVREVDNKALPFGKFLSYGPCQTPVLGLVVSRELERLNFKPEEYYVVKGIVETEAGSFEARSRPFKAREEAEAAVRAARVSLGKVIEARFEETRVKPPAPLDTVELERRASKWLNIRAKAALDTAEELYRRGYISYPRTETTIYPPTLDLRAVLEELTNTQFGQYAERLLRGPISPTRGNSDDRAHPPIYPTRGATKAEVERALGTRAWKLYEFVVRHFLATLSPPAIVERQRIAVAFGPLVLEAEGRRIIERGYWEIYPYEEEEDRRLPRVQAGVWARMVSAKIEKKKTEPPPRMSESELLRLMKKYGIGTDATMQDHIHTNVIRGYMRIVGGRCVPTKLGMTLASSLMNHARPIIDPTVRSKMEAALQDIAVGRADVKKVLETIRGEFKTFYKGLYEKRQEIARELVKVLREETRNGPRSDV
(75) Reverse gyrase [Staphylothermus hellenicus DSM 12710]
6
MVELKHIHGYYRYSCPNCAGENSDLRLIYKAPCDKCIEEELFDQIRENISKKSYKEILETYYKVLQKHNKLKKRFESLYKFEEKLEKFEEFFSRATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYLSKKQIMIQKNRASRKKVYLVFPTTPLLLQAEKKLRKLAEQARIPVCQEENHDQTCLNIISIHGRVSKKKREKLLEEIKSGNFDILLSTNMFMHRNYELLLGKKYELIVMDDVDAILRSGKAIRILFYLLGLTDQEINEAIEYLKARQRLAFRLSEEKRRELEQKLETLEKRIEKYKRKIGTIVIVSSATGKPRGIYPRLFRILLNFEAGSKAEAIRNIVDTYTYPEESIEQTIIKLAKKLGNGGLIFVPIDKGVEYAETIAELLKKNGINAEAFHAKKAVKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFSTRLETPSPTDVLRIFTILRDVLEGEEKRKAEILIGRISLRLRRLSQGALMKLKEDFIKKLQGEEVEEYPLLSMLIEALSMARELLSKPEIWEKLKQKGDVALIQEDGKSYILIPDVATYIQASGRTSRLYPGGITKGLSIVIVDDQRLLNGLTKRMRWLYEEFDMRRLDEVDLDNLMKEINEERRKVKMILEGKIEAEKTLELTKSALLIVESPNKARTIANFFGKPSIRILENGMPVYDVTTGDYVLSIIASIGHVYDLVVDDGLYNYGVRLVGDKFVPVYTDIKRCNKCGYQFTAETNTCPKCGGRDISRKLDIVETLRELANEVDTVFIGTDPDTEGEKIGWDIKVLLEPYAREIKRVEFHEITRRAILNAIRNPRDFDMKLVEAQIVRRIEDRWLGFALSKKVQKYFWPKYCVEALIPSLYKMIRKKKKKIEKMPNCCVENRNLSAGRVQTPVLGYIIERYRDHNDVSKYKYLLTIKIDDNRLRVDIDRSVLENIGTTSPRDLIGYRVEVLEGDRKEEIINPPPPFTTDTLLEEASMRLGLSTTRTMEIAQELFELGLITYHRTDSIRVSDAGINVAKQYLEEKLGEKAKEVFKPRTWGTGGAHEAIRPTRPIDADRLAELIREGALILARPLTRLHYLVYKLIFNRFIASQMIPAKIVKQILKIRINGYEKNVERVIGIIEKGFLEFYQTVNIEEEVKPGTYPIVDVEELKPPLARYHDVIKWMKIKGIGRPSTYAKIIQTLIDRRYVNVSKRVKALIPTRRGIMVYEEFLNKYYRDVVGVDVTRELEKKMKEVEEGVRDYQEVLWEIYNELRTKIIDNPIVNKELERQWSMYCGQTEYSK
(1720) Reverse gyrase [Staphylothermus hellenicus DSM 12710]
6
MEKILDPIYKNLCPTCSGDVFANSLWDFGVCGKCSGETRNSFNALTLYRAFKEDLEDFTSFFRKATGNLKPWGAQLTWVKRLLNGENTVIVAPTGMGKTTLLVVYSVYVAKNYGKKVLFFAPTRALAKQIYNRIIEAAENVCGTCINILFYDSGLSKKRREEILLKIKNNEYDILVLTNHFLNRHYDLIDPSHIGLIVIDDVDSLMRSSKNILRLMKLLGFHEELIEKAKKRNSIIWKLMLSKSLNKEEDYRRYIEELIEIEAEIDKLLRNTSRKQVVIASATGRMKGTYAKVMRDLLRIDVSGITVYGRNITDTYLLINDYVSDADNIIEVIKILGPGALIFISPRHPLKKKLLELVKLLREKLEERGYRVAEANPSTIKKFIRGEYDFLIGSSSYYGVSVRGIDAPETIKYVLFIGTPLFTVELGSFLASPNMLIRVSLMLSEVLGDQRYRGMASAIRRLVFPLNSGEIKLLSMLLKNKITINDLGKDSRVAKVYEQILGFYNEIRKSLEELLSKKKVVNMNTITFYHADNKFYALIPDVMTYIQASGRCSRLYLGRMTHGLSLVVEYEFLSNLVNGLSLKMNMFSHGFVFKDISNVDLYGERKLIEKTRRELKGPVLTYRNILVVVESPTKAKTIARFFGKPVRRKIGSISVYEIPFVKDSEVIHLNIVATRGHLFDLTTDPSIPNHGVLIEDHRISPVYTSIKRCRICGHQFTYGDRCPRCGSTSFTDSYEVVNVLRKLAQEADEVYIATDPDIEGEKIAYDVYLTIKGFVDKVWRIELHEITLNEFLNALENKRDINRKLVEAEIYRRVLDRIIGFSLSQELWRKYSKKWLGAGRVQTPVLGWIIDHYNEYVSNKCRKIIYITEHKGFKFSICIDLKDKDLYKEMRSVDHVTLVLKNSRIETFNPPPPYTTDELLYDASRIGIPSSLTMKIAQELFESGLITYHRTSYHYVSSAGISVASKYLENKDLMKHFHPSHWGNKGAHEAIRPVHPLDREDLEKAVVEGIVAPTIPLTWLHYRVYDLIFKRFISSQMNPYKALIGEYDVVINNKVVKTLVLPIEIVEDGFNIIMGSKTYSFLKGHDRVNISIKDIKAMVTSTKPLCSEGGLVKLMKEHGLGRPSTYSKIISSIVRHGYVIRSKKRGFLIPTKTGIEVYNYLSNSFPELVSIDTTRDMEMRIDLIAKGEMRAADEISRVLDRIRRYKLPLSIREVVAEASA
(1275) DNA topoisomerase 1 [Staphylothermus hellenicus DSM 12710]
3
MKVKAKKSIIDYILSYSKKQEKEHVKAEEKTLPRKVTEKAKIKITRNIWDLTGKIVVIAEKPKAANKIALALSKNPIRKSIYGIPYYMIKTKNGLIIVASAAGHLYGLHTDQYGYPVFRYEWKPLYQIGHKAKHTKKFITALSKLCSNADYYVNACDYDIEGSVIGYLIIYFHGDLEKSLRAKFSSLTIGELRESFRKLTSLDWEMIEAGLCRHELDWIWGINISRALMSSVKMASGKRVILSAGRVQTPTLRYIVEKDIERRLFIPLPQYSLSINISKNNYEIHVEYKGKAVETKKKAKEIIKDIKNTGYLTVKKYEEKKYWLNPPPAFNLGDLQEEAARIYRFSPYKTQSIAEKLYLDALISYPRTNSQKLPPTLNYKGIMNKLSRINNYKELISNLLVETRGVLKPVQGPKDDPAHPAIYPTGVKPKDLGKDEWKIYDLIVRRFLAAFASRARISHRIVYLEYPKDPSMVFMASGRKILELGWLRYYPFSMPEERFLPRFQHGEKVKITKASIRKTYTKPPEKISRIKILRWMENVGIGTEATRARIIEILFNRKYLRSVGGRVEATDLGLGIIEVLMEYFPEITSVSLTRYFEGEMEKIRLGIRRRDEVVRDAKNTLIKLIVSFDKKKYQIGKTLSYRLGYLTPTNKCMLCNREAYKNNLCKYHYQALNTIVKTYEEWKRREGVDWDKYLSSIKKLKSTGKWIVEVIQNFEKIKYSHSK
(1183) DNA topoisomerase [Metallosphaera sedula DSM 5348]
7
MKLVITEKPSVALDIARALGKPTRRQGYLEVGEYLVTWTYGHLLEIGEIAPKRWNLKDLPIFPEKFEYDLIKGKESQFKVVRKLLEGADAVINCGDAGREGELIVRELLEFTGYRGKVLRLWTSEALTRDVVLRELRRLRPSSEFDSLYYSALARQNGDWIVGINLTRLVTLKAGGGEVWSVGRVQTPTLAMIVKRDREIEAFKPEIYYVVLAGFEGEMKGVMLRNGEEARLAREEAEQVVNALKSVRSGRVEKVDVERREERPPLLHSLTSLQREANTLYGLSAKRTLDVAQSLYEEWKLISYPRTDARYLGEGNRDLVKDVLRKLGRGELVPRVDRVGKRVFDSSKLTDHHAIIPLDRPPENLPAIHRKVYDLVYRKFVGAFMDDYVYELQRVFIRLDGELFLVEGKRNLQLGWMELYPHEDNPLKIPSGEVRKEWVKAEERQTKPPARFTEASLLREMERLGLGTPATRAGIIETLLERGYVERRGKSLYSTDKGRELVDKLGDSKVVSPDMTAEWERQLEEIYVKRLGEKGYQEFMEGIRRFTREEVERLMKREFKVERRATPEMLRLARAVSRDLGVKLEGTGMEEVKRFLDENLPKMRITCKCGGEVVGFSRGWKCRKCGTVVWREIAGKKITFRQAKSLFQGKELKMKGFRSRTGKRFSATVYLEDGKVKFKFE
(1748) Reverse gyrase [Metallosphaera sedula DSM 5348]
6
MITSVFHSSCPNCQGPLEDYRALAGLPCTSCMPGSVDSFKDLPQEEKIKVVYNILVNNGKLGKYWELYYTTEMYNEIINYFKQVTGNEPWSLQRLWLRRLGERENFSLSAPTGMGKTTTLITYSTYLSKGVLYIVPTKSLQEQICSKIGAISSVSCGKVDPNTISVLTVSYVNKNYDHMKDYRPNFIAVDDADAIIKSGKTTDKLVELMGIPKDVYEDAMRLVRLRRMLYLKDNKDEIVEKIALLERKIQSFTGIIAQLVVASATLRPKGVKQKALRHISGFDISTAQTYARNIVDSFTFSSLEEVVQKLGPGGLILVSREYGKEKMKEIKESLTSLNFRVELAVSGRKFLQDFSDGKTDILVGSASYYGVAVRGIDEPKRLKYVLFYGVPKSRTRAEESVKNPFTLLRVSRLLGIQVPEEEILGLSPAEAQAIKIAMITGQSLEGRLGALLEKMKVLVEEAQEALRKVDGTITGETFQISRKGREVFIEYPDIITYLQGSGRSSRLLNGGLTQGLSVILVDDQVIFELFKRKMNFLIPGFAPVNFEALELDRVKEEIERTRREGGNKVEIKTGLLVVESPTKAKTISRLFGFPARRSVGGVPVYETVIVEGNRVYILDVMATKGHVTDLTLEEKGYYGVEIKGDKISPLYSHIYRCASCKRSVSKEVETCPYCGSNLISSSLSTINAMRKLALEVDQIFIATDPDTEGEKIAYDVAVNVSPYNPNIMRIRYHEVTRSGIVEALRSGSTLDMNTVNSQIVRRIEDRWIGFELSKLLKLRFGDRNHGAGRVQTPVLGWIVKRTTEYKQRMGWILNVKVGNYVYREFHREKPNIPDSTVEVEVLEEREETLLPPPPFSTDDLLIDAYRWYRIPAERVMRLAQDLFESGLITYHRTDSHHVSGKGMEIAKEYLEKVNLSQEYQPRGWGNEGTHEAIRPTRPLDVDSLKREIAENPTMLSVKFTWAHFALYDMIFRRFMASQMRESKGTIRKYRMKLGESIWEVELLVRMSGGFSNLYTYRLYDVPVGKVNAEINVVRGSDVKLLTYADVIKDMKEKRIGRPSTYAKTIQSLLRHGYVIESKRKAVLVATKKGINAYEFLSKFPDLTSEEVTADLLSKMDAISSGSLEPTTVLLPVLRELQGLETLPKSEQEI
(1035) Reverse gyrase [Metallosphaera sedula DSM 5348]
6
MNADERLPDVVYMGSCPNCGSDITSVRLGKGSVCERCLGEEIDIGSLQQLVEILQNAGTIKSLLREKNILEEERKVIDLFKRVIGSEPLGPQRSWIIRALRGESFPIIAPPGLGKTTFGIVMSLYYASRSEKSLMIFPTRTLVSQVVQKIQEMGKSLDFTPRLVYYVSGLTQSKKDELSKSLAEEDFDIFISTSRYVIQHLDEINKINYKYLFVDDVDAVLKSGKSSLTILKLMGFSDENVTKVRELLKTSRDNTSSFDEIRKIRERFAKDRVAIFSSATITRSNPVFTSLMGFKPGGATIYLRNVIDSYIIGTDIVSQTVELVKRLGPGGLVFVPVDKGLNFAREISQKIDFLKASVVSSNTTKKLEEFEQGSIDVLIGVATHYGLLVRGIDIPWRVRYAIFAGIPKFRFKLGETMHPLAMLRILTLLSVVLKDPEITRILRFVKYRLRRTSTAALAMLAKAVKDGALEDRTMIRAYEIVNTYLKDKRIVEAISKFGDISFSGDYISIPDYLTYIQASGRTSRLYGGHLTTGLSVLLVDDMILFDLLKKKLSFILDDMKWNPLDLDSQKIGDRDLQEIVKQIDKERAEIIRRRKIEPISMPMEKIKTVLLIVESPNKAKTISNFFSRPSIRDFDGLRVYETVIGDKILMVTSSGGHVYDLTTKDLGVYGVEVKSNGDVNVIPFYNTLKRCENGHQFTEYAEGGKCPICMSTNVRDKRSAINVLRRLVLEADEVLIGTDPDVEGEKIAWDLYLNLKPFNSNIFRAEFHEVTRRAITEALNSPRTFSINMLRSQLVRRIEDRWIGFKLSNKLKEEFWKEYCTKTLGNKDCDTENRNLSAGRVQTPVLGWVISRYEEYLRTKRTMYVAKAGNLNILIPKQQGIRKNSKIKIVIQSAERKQDTLGPFPAYTTDTYLSDASGFFFISAQEAMRIAQDLFENGLITYHRTDSTRISNVGIGIAESYLKDLLGERYREIFVPRSWGEGGAHEAIRPTRPLNGEQLRAMVEQGEIEPSKRLTYNHYRLYDMIFRRFLSSQLVPLVVEKEILQISAKKGDETLKLESDTLEIVTNVRLSKDVPIPSEILYIPFRSIGETLLTQIKDKLPAEIDAVITSSFQKSDHALYTQGELVSLMKQRKIGRPSTYAFIISTLLKRGYVFETMKVKRLIPSKLGQHVYEFLNSRYSNFVSEDRTRSLLERMDLIEEGKEDYRQVLKQLYNEIQDIR
(575) Reverse gyrase [Metallosphaera cuprina Ar-4]
6
MNVSDDIPNIVYIQSCPNCGSNITSLRLVQGLTCENCLADGKIKINELSELISILEEQNKIRLLQNEKNILNEEKNVVQLFRKVVGTGPIGPQRSWIIRALRGESFAIVAPPGLGKTTFGIIMSLYFASKSQKSLMMFPTKTLVSQVVQKIQEMSKLLDQPPRVLYYSSGITRSKKAEFNKSLNERDFDVLISTSRYVMENLDELNKIKYRYLFIDDVDAVLKSSKSSITILKLMGFNDDNIGKARELLRLSRDDKSSFEEIRKIRKKFMGERITIFSSATITKSNPVFTSLVGFKPGSATIYLRNVIDSFVVEENPVIQVNQIVNKLGPGGLIFVPIDRGLKYAHEIEKGIEGLNVSVLSSNSTKKLEEFENGSLDILIGVATHYGLLVRGIDIPWRVRYTLFAGIPKFRFKLGETMHPLAMLRILTILSVILKDPNVTNTLKIVKYKLRKISTAALAMLAKSVKEGDLEDRNLIKAYEIVNYYLKQKNVIEQISRFGDVSVNGDYISMPDYLTYIQASGRASRLYGGHLTTGLSVLLVDDTTLFELLKKRLSFILENLSWSPFDIENETVGGIGLKDIIKKIDSERSEIMRKREMGTISQSLGRIKSVLLIVESPNKAKTISNFFSRPSIREFEGLRVYETVMGDKILMITASEGHVYDLTTKEIGIYGVEVHSGDDSHIDAIPFYNTIKKCENGHQFTEYGEGCICPICGSKNIRDKQRSISALRELAMEVDEVLIGSDPDVEGEKIAWDLYLNLRPFNNRIYRAEFHEITRRAITESINSPRNFSVPMLRSQLVRRIEDRWIGFKLTSKLKEEFWRKYCTEFTSRNDCEAGNRNLSAGRVQTPVLGWIKNRYEEYKSTKKKVYVARFNGFSVLVPVQPGIRKNTKVKIIIEDLQRKQETIGPFPAYTTDTYLADASTFYLIPTQESMRVAQDLFESGLITYHRTDSTRISNVGINVAETFLKDMIGEKYKEIFVPRSWGEGGAHEAIRPTRPLNAEQLRVMIEQGEIEPSKRLTFNHYRLYDMIFRRFLSSQLVPLVVEKEVVKISCKKGETTLSLDSNVVEQVVKVSLQKDVGLPSDNLYIPFRSVSTSLDKVVRGTLPFELEATLTNSFIKSNSLLFTQGELVSEMKNKGIGRPSTYSSIISTLLRRGYVFESMKSKRLIPTRLGEEVYKFLSYKYGKFVSEDRTKDLLKRMDDIEEGKGDYRQVLKELYNEIKGIR
(695) Reverse gyrase [Metallosphaera cuprina Ar-4]
6
MITSVFHSSCPNCQGPLEDYRALAGLPCTNCLAGDEEPFRDLPQSEKIKAVYNLLVNNNKLAKYWELYYTAEMYDEVINYFNQVVGKEPWSLQKLWLKRLGERENFSLSAPTGMGKTTTLVAYSSYLSKGVLYIVPTKSLQEQICSKIGSISSVSCGYVDRDGISVLTVSYVNKKYESIKDYRPTFIAVDDADAIIKSGKTTDKLVELMGIPKDIYEDAMRLVRLRRSLYLKEDKDEILEKITKLERKIQGFTGAIAQLVVASATLRPKGIKQKALRYISGFDLSNTQTYARNIVDSFSCSSIEEVVQRLGPGGLILVSREYGKEKMREIKDKLTSNNFNVELAISGRKFLQNFSEGKTDILIGSASYYGVAVRGIDEPKRLRYVLFYGVPKSRARAEEAIRNPFTLMKIARLFGVNVPEDEILSLSPAEAQAIKISIIKGQVLPGKLGEVQKKLEDKISEVQEFLKSVNGIVRGETFLISRRGKDVFIEYPDVITYLQGSGRSSRLLNGGLTQGLSVILVDDQILFDLLKKKMNFIIQGFNPVQFESLNVDSITKEIERTRREGGNKIDISTGLMIVESPTKAKTISRLFGFPSRRTIGGVNVYETVIVDGNKVYILDVMATKGHMTDITLEDKGYFGVDVKNDVITPLYSHIYRCVSCKRVVSKEIDVCPYCGSSLINSSLSIVNAMRKLAMEVDEVFIATDPDTEGEKIAFDISVSVSPYNPKVRRIKYHEVTRSGIVEALRTGTSIDINTVYSQIVRRVEDRWIGFELSKLLKSKFNEGNHGAGRVQGPVLGWIVNKTREYKERIGWLLYIKVGNYVYREYHKTKPAIPDGPVQVEVVGERVETLQPPPPFSTDDLLIEAYRWFKVPAERVMRIAQDLFESGLITYHRTDSHHVSGKGIEVAKEYLEKMNFTQDLQPRSWGPEGAHEAIRPTRPLDLESLKKEIGENPMLMSVKFTWSHFAIYDMIFRRFMASQMKEAKGVFKRFAMRMKDRSWEADLLTEMEGGFSRLYKYRTYDIPIGEINPEINLSRGSDVKLLTYADVIKEMKEKNIGRPSTYAKTVQSLLRHGYVVESKKRSVLIATKKGINAYAFLSKFEDLISEKVTADLLAKMDSIVTGKAEPTSILLTVFDNLRSLEALPQSEQEI
(344) DNA topoisomerase [Metallosphaera cuprina Ar-4]
7
MRLIIAEKPSVARDIAKALGKPVRKEGYLVVGENLVTWTYGHLLQIGDLAPRKWDLKDLPFFPERFWYKAIPGKERQLKVVGTLLSKASEVVNCGDAGREGELIVREVLDYLGFKGRVLRFWTSEALTPEVVRREFMRLRDSSEFDDLYFSALARQNGDWIVGINLTRLVTLKAGGGEVWSVGRVQTPTLAMIVRRDEEIESFKPETYYVILGKFEGIEGVMLRDGVEARLGKDEAERTVSKLEKESFARVLKVDKEERSERPPLLHSLTSLQREANVLYGFTAKRTLDLAQRLYEEFKLISYPRTEARYLGDNNKGLAKEVLKRLGREELIPRVDRVGKRVFDSSRLTDHHAIIPLDKAKDDLPRQERMIYDLVLRKFLGAFMEDYEYEVQRLYLQLDGEIFLSQGKRNVRLGWMELYPHEDNPIPLPSGSVRKDEVRVEARQTKAPPRYTESTLLREMERLRLGTPATRAGIIETLIERDYVRREGKTLRSTGKGRELVKKLASSKVTSPDMTSEWEKELEEIYVKRRGREGYDEFIGKIKEFTREEVVKLLKEEFKVENRATPEMLSLAKMVSKDLGVEVPGTGMEEVKRFLDEYLPKRRITCKCGGEVRAFERGWKCVKCKSVVWREIAGKRITFKQAKALFEGKELKMRGFKSRSGKRFSAVVYLEDGKVKFKF
(372) Reverse gyrase [Pyrobaculum islandicum DSM 4184]
6
MDVPHVVYLHSCPNCGGPITSDRLAAGLPCYECLPKEPQAKAIGEVVEALRRRKALKELARVAEYLREYNKFSAFFKEIIGYEMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFILVATLYMALRGKKTLLIFPTSALAHQAYKKLMSFAEKVGASVKTLAYHSLLTEKEKDEVLAAIERGEFDVLIITSAFLPRRFDLLSRYKFEFIAADDVDSILRATSKNIDRILKLLGVSDEVLKTALDIISLTKQIRKAEVVGDLKEVERLEQELSSARAKLQEEVRKLKLGIFIASGALAKARRTTRLLLFRELLGFDVGGRAEGLRNVTDVYIDMSQDVVMQTIEILKRLGPGGIVYVQDRELGIAIAEKAKERGLSVEHFFKPRRGILESFEKGEIYALVGLASPRSPLVRGIDLPHVIRYVVFVGVPKYRFRVRLEEFSIPAYLTFLYNVRTVLTGELRYKADRLIGQLKRLAPYAISVQEALRKASEGAELTGFDRHVVDVVKSAVDFVNNLLMRDDLRQAIESSTEVKLTRIDDEFYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDKKVFHALKRELKLRFDEAEFKHIDEVDLNAVLAEIDKDRKAIRDILEGRVTPATKGVELLKTVLMIVESPTKARTIANFFGRPSLIVTDGVPIYEVSTGDAVLMITASLGHIYELPTSLKRIDSRQREILAKWFGEFKYDSYNGEEYAVIVKEGSFIPVYNKIWRCRNAVYIDDTDVPPDCKPLDVLSAIRNIAIEVDTVLIGTDPDSEGEKIAFDLYLGLRPYVSDIKRVEFHEVTRRAILNALANPRDINYSLVKAQIVRRVEDRWLGFGLSKILQTKFGNPNLSAGRVQSPVLGWIVKTYEESLKNRVYNVDLQLDAAYCVEPSSCVLRLQIPGDILQTLKKKKRVAIKKESEEERVVNPLPPYTTDELLRDAVNRLGLSADYAMKVAQDLFESGLITYHRTDSTRVSAAGIAIAKEYITKRFGEGVFKPRSWGEATEGAHEAIRPTRPLDVEELRGLVNAGVIQLAIQLRREHYQLYDWIFRRFMASQMEPSVVKAIKYVIEIDGHSLELERVVETIRPGFQQLYPLTPVEPELPTGTIEVAIKRYRVVRKVLSQADILALMRQRGIGRPSTYARILQVLAKRYYVYVVGRRKLMVPTKRGIEVYHFLENNFSNLVSEERTRLIEQYMDAIEVGNAEYEGVLKELFDEFTREILSRAPLT
(1250) DNA topoisomerase [Pyrobaculum islandicum DSM 4184]
3
MILIVAEKRSVAQAIARYLGGTYKVEKIYGVSAYRFLYGNREAVALGLSGHIMDYDFTARQNVWSWLPPEELFKTSPILVLREEAIKYVRALRSLARKAEEVYLALDADSEGEAISYEVALVVRLVNKNVKIYRVRFNAVTYKDIKIAFQNPTKLDLKQVEKVFSRMQIDLTLGAVFTRFLTLTVRDLLEKGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKAVVEIRGYKIEMSADVRFKTRKEAEAVATTIKRGVVKAAIYRPHYIQPPEPLETVELERRASRWLGINSKKTLDIAEELYRAGYISYPRTETTIYPPTLNLREILQELIRGEHSRYVEELLLRGFRPTRGDSDDGAHPPIYPTKGATKSEIYKTFGKIGDNAWAIYDFVVRHFLATLSPPAQVEKQKIVVDFGKIQLEVEGQRTIDEGYWRIYPWERQSDRPLPRVYVGDEVHAIKVEVVERETEPPPPMSESELLALMKKYGIGTDATMQDHIYTNIKRGYMKLQKGKCIPTKLGETLAITLFQYTPELIEPTVRARIERAIQGIVKNGISPNRLIQEIKSEFEKYYNDLKKHRDEIRRALETVLNSKARERSGTY
(509) DNA topoisomerase type IA central domain protein [Pyrobaculum neutrophilum V24Sta]
3
MDLIVAEKRSVAQAIARYLGGSYKSGRLYGVPFYSFTYLGREAAALGLSGHIMDYDFTARENVWTWIPPEELFRATPVLVFRPETANYVKALRSLAKKAERVYLALDADVEGEAIAYEAALVVKLVNRRAEIYRVRFNAVTYRDVRSAFQKPTKLDLRQVEKVFTRMQIDLTLGAVFTRFLTLTVRNSLERGRFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKALVEIGGHAVEMASTERFKTRREAETAAASVKRGVVKTAVYRQHAVQPPEPLETVELERRASRWLGISSKKALDTAEELYRAGYISYPRTETTIYPSTLDLREVLKELAGGEHGPYAEELLKRGFKPTRGDSDDGAHPPIYPTRGATQGEIYKVFGKLGRQAWAIYDLVVRHFLATLSPPALVEKQRIVATFGGVELEAEGQRTIEEGYWRIYPWERQRDKPLPRVEAGEAAKAIRVEVVERETEPPPQMSESELLALMKKYGIGTDATMQDHIHTNVKRGYMRLQRGKCIPTKLGEALATALFQYAPELIEPTVRAKMEKALQDVVRGAAAPTRLIQEIKDEFERYYKALKERRQDLKTTLETALKSMSEDGSGGG
(1187) Reverse gyrase [Pyrobaculum neutrophilum V24Sta]
6
MDLPYVVYLHSCPNCGGPITSDRLAAGLPCRECMPKEPRAASLREVVEALRRRRALRELSWVADYLREYSDFSSFFARVVGYEMWGAQRLWARRLVRGKSFAVVAPTGSGKTTFVLVSALYMAGRGRRALLIFPTSALAHQAHRKLLGFAERAGLNVRVVAYHSLLGEKEREEALAAVERGDFDVLVVTSAFLPRRFDLLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDEVLKTALDAINLAKQLRKAEVAGDLKEAERLERELASLRAKLQEAVRGLKLGVFIASGALAKARRTTRLLLFREILGFDVGGRAEGLRNVVDLYVEAAHDVVQQTIDLLRRLGPGGIVYVQDRELGMAVAAKAREEGLAVEHFFRPRRGVLERFESGEVAALVGLGSSRSALVRGIDLPHVIRYVVFVGVPKFRFRVRLEEFSIPAYLTFLYNVRSVLAGEARYRADRLIGQLRRLAPYALSVQEALKKAAEGAELTGFDRHAVDVVKSAVEFVNGLLAREDIRRAIETSTEVKLAYIDGELYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVVDDQKVFQALRRELKLRFDEAEFKHINEVDLGAVLEEVDKDRRAIRDIMEGRVSPAARGVDLLKTVLMIVESPTKARTIANFFGRPSLIIADGVPIYEVSTGDAVLMVTASLGHIYELPTSLKRVDPAQRAVLAKWFGDLKHDGYDAEEYAVIVKEEGFIPVYNKIWRCRGAVYVDDADVPADCRPLDVLSAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVSDIRRVEFHEVTRKAVLNALANPRGVSYPLVKSQIVRRVEDRWLGFGLSKLLQAKFSNQNLSAGRVQTPVLGWVVETYEESLRNRVYNVDLQLDDVDLRLQIPGDVLQVLRKKKRVAIRKTGEEERAVNPPPPYTTDEMLRDAVNKLGFSADYAMRIAQELFESGLITYHRTDSTRVSTAGIAIAREYVAKRFGEAAFRPRPWGEAAEGAHEAIRPTRPIDVEELRGLVNAGVLQLAVQMTRSHYLLYDLIFRRFIASQMEPSVVKVAKYAVEIDGHVLEIERAVDIVSQGFQQLYPVTAVEPELPTGTLDVAVKRYRVVRRILSQADVLALMRQRGIGRPSTYARILQVLAKRYYVYVAGRRKLMIPTKRGAEIYHFLRENFGSLVSEERTRLIEQHMDAIEVGKARYEEVLKELFDEFRRDVLPRLAYFST
(1045) DNA topoisomerase [Pyrobaculum arsenaticum DSM 13514]
3
MILIVAEKRSVAHAIAKFLGGRYKLEKIQGVAAYRFNYGGREAVALGLSGHLMDFDFTARQNVWTWIPPEELFASQPLIVYRPETMKYIRALRTLAARAHEVYLALDADVEGEAIAYEAALLVRLVNPRAKIYRVRFNAVTQREITNAFRNPTHINLRMVEKVFTRMQVDLTLGAVFTRFITLAVRHSLDRGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVVKALVEIGGHRIEMSADVRFKTRKEAEEAAATINRGVVKAAVYRPHHVNPPVPLETVELERRASRWLGINSKRTLDIAEELYRAGYISYPRTETTIYPPTLDLREVLQELASGHLGSYADELMRRGFRPTRGDSDDRAHPPIYPTRAATKGEVAKAFGKLAPQAWAIYDFVVRHFLATLSPPAVVEKQKIIVSFGKLEMEAEGQLVVDEGYWRIYPWERQSSKPLPRVSPGDPARAVKVDVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIHTNVRRGYMKITKGKCIPTDLGIALATSLFQFAPQLIEPTVRAKIEKALNSIVTDGTPPARLIYEIKKEFEEYYKALKARKEEIKKALETALNSSRNSQRG
(992) Reverse gyrase [Pyrobaculum arsenaticum DSM 13514]
6
MVPLVVYLHTCPNCGGPITSDRLVLGLPCRECLPEGTKAGSIREVVAALRRRRVLKGLAWVDAYLRGYEGFTEFFKKVVGFDMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFVLVAALHVAKEGKKALLIFPTSALAHQAYRKLLVFAERAGVSVRALAYHSLLSDREKKEVLDAVQRGEFDVLVVTSAFLPKYFDMLKAFKFDFVAADDVDSILRATSKNIDRILRLLGVSDSVLSTALEVINMTKQLRKAEVAGDLKEMERLSQQIAELRAKLHEEARRLRLGIFIASGALAKARRTLRLMLFREILGFDVGGRAEGLRNVVDLYTEASGDVVEQAVELLKRLGPGGIVYVQDRELGMAILERAKAEGLAVEHFFRPRRGVLESFEKGELVALVGLASSRSALVRGIDLPHVIRYVVFVGVPKFRFRVRLEEFSIPAYLTFLYNVRAVLASDLRYKADRLIGQLKRLAPYALSVQEALKKAAEGAELNGFDKHAVEVVKSAVEFVNSLLEREEIRKAIETSTEIRLTYVGGELYVLVPDVTTYIQGSGRTSRLYVGGLSKGLSVMIVDDAKVFQALRRELKLRFDEAEFAHIKEVDLDKVLQEIDRDRRIIRDIIEGRVAPERRSVELMKTVLMVVESPTKARTIANFFGRPSLLVAEGVPIYEVSTGDTVLMITASLGHLYELPTSLDRIEARQREMLLKWFGDFKTDGYDGGQYAVLVKEGAYIPVYNKIWRCRGGVYVDDVDVPPECKPLDVLEAIRNVAVEVDTVLIGTDPDSEGEKIAFDLYVSLRPYVQDIKRVEFHEVTRRAIINALANPREINFSLVKAQIVRRVEDRWIGFGLSKILQNKFQNPNLSAGRVQTPVLGWVVKTYEESLRNRMYNVDLQLEEGELRIQISREALDVLRKKKRVAIKLAGREVRSLNPPPPYTTDELLRDAVARLGLSADAAMRIAQDLFESGLITYHRTDSTRVSAAGVAIAREYITKRFGEDLFKPRTWGEEREGAHEAIRPTRPIDVEELRGLVNAGVIQLAIRPTRAHYQLYDLIFRRFMASQMGPSTVEVAKYQLEIDGYVVDIERVVGIKEMGFQTLYQVSRVEPELSTGTIDVVIKRYRVVRRILSQAEVLALMRQRGIGRPSTYARILQILSKRYYVYVTGRAKLMVPTKRGIEIYHYLEEAFGPLVDEERTRLIERHMDMIEEGKAKYDDVLNELFTEFRKEILPHLSA
(1708) DNA topoisomerase [Ignicoccus hospitalis KIN4/I]
3
MKGHILVIAEKPKAAEKIANALGKPIVKRKYGVPYWELTNGKKIVVVPAAGHLFGLAPLGKGFPVFDYEWRPLYEIEKGASHTKKYIALISSLSPGSSLYVNACDYDVEGSVIGYIIIERFGDPRRSKRMVFHALTPDEIRRAWNSLRPLDWEMINAGLARHELDWIWGINVSRALMHAYRVATGKSKSLSAGRVQSPTLKEVVERELAVQCFVPEPYFSVSLSAKGVSLEPTLKFETKDEADHFISNCLGKVVDVIVNDERLSPPHPFNLPDLQMEAARLYGFSPSKTQSIAEELYLDAYISYPRTNSQKYPKDLDYANILKGIASVPQYRPLTKALFKETRGRFSPNNGPKDDPAHPAIYPTGKPPKNLSPDHMKVYDLIVRRFMATLASESVYEVTKVVIEVNGQTFKAVGRRVKWKGWTLYYPFSAPQEKSLPSFTKGESLQVKCTRRLQYTKPPERYTKAKIVKWMERVGIGTEATRARIVETLFKRGYLKNVGSKVYATDLGIGVALVLSKFFPEIVSVELTRRFEEDMKKIMMGVERKEKIVEEAKKFMRMILAKYKPHMREVGEYLAYSLGEMEPPGRCAVCWRVAEEDGLCVVHKRARDELYAKYPVWRRRLGLSFEEYLKKVTTLKQAGTAAKEVAKALLSEPTFKG
(1264) Reverse gyrase [Ignicoccus hospitalis KIN4/I]
6
MYASYRRSCPSCGGEIEDVNLSLGLPCDKCLRVVGLESLKLDPSKKDSPSVRRRLIELGGPLGESLKLEEELESLEKVFQEVLGAPMWSAQRAWALRALRGESFSIVAPTGMGKSTLGALLSVYLSHKKKKKSYIIVPTTPLVDMMFRKVSAFAEAFGVRAVYFHSKMSPSQRKEMKERLLSGDFDVLITTSRFLINNLDLLKNYEFGFVFVDDVDSVLKSPKNVDRILMVLGLQESDVKRLEEVDKELSRKAQVLTKLQDLQKRYQLLKEMRELEEELEDLKRKVKGNLIVSSATGRAKGNRVRLFTRLLGFTPGGVGEGVRNVVDSYSRSSDVVEVVKKLGKGGLVFVPADLGAKGAEEVAEALRAAGVAAEVATSERIGVIKDFEEGRVEVLVGVATHYGVLVRGIDLPHVVRYAVFVGVPRFKFKLKLEEPSPMTIYRLCSLAARFFEECASLYAKLRKWVQRLGPAGLQSVEEALKEGSASTPASKDFMEAYTKLKEIIEKTDFIEKLKESGEVDVVAEDSLYVLIPDAATYLQASGRTSRLYAGGVTKGLSVVLVDSEPLFRGLKKRLAWVVEEWKEFESLNLSELLKEIDEDRKKVLKVIRGELKVEEVRDLMKTVLMIVESPNKARTITSFFGRPSVRQVKGVKVYEVTLGDKLLYVAASGGHVYDLVEEADPCNEEPCMLFGIRVKDVPEEVLSSIKRCAVCGHQFSGDVKECPRCGSPFIKDAKDVVDGLRELAQEVDEVLIGTDPDTEGEKIGWDLKNLISPFAKKIRRAEFHEITKKAILKALENPRDFDMGYVWSQMVRRAEDRLTGFTLSPKLWFELWPQLCEVSKEMKKKLLGCPLTRNLSAGRVQTPVLGWVIQRYEEYAKSKKKFYIIRFDGRELEFSEDELRGFSKKLAIDGKVKILKVEEEVEELKPLPPYTTDTMLEDASKLGLDPSRAMRVAQDLFEMGFITYHRTDSTRVSDAGIAVAREWITSKFEGLFAPRRWGEGGAHEAIRPTRPLSAEDLKRLIEEGMITPPRELSKQHFMLYDMIFRRFMASQMKEAKVKKAVYEITVEEGGAVVGKKVLEKYVERVFDGFLLVYPIVKIESLPEGEYEVKEVRAVSRHTVPLYTQADLIRLMKERGLGRPSTYAKIVSTLLERRYVTLSKVGKKLVPTVRGYAVYSYLTGKVVGAGWVRKALEVIINPEGKSKYFQKLVEEEATRRLEKVMDEIAEKKDEKMYINVLKDIIEETKVIPFLSDKGAQPSLR
(1683) Reverse gyrase [Ignicoccus hospitalis KIN4/I]
6
MIEAVYQRSCPSCGGDVERERLLAGLPCSKCSEPRGLLAWKEVLEEEYEAFANFFKKAYGFELWGPQRAWAKLALSGSDAVLLAPTGTGKSTFLAALSSFLKRKGKRVLYVVPSKSLEEQVKERLAEEVDVITMRRLVRDPRAYRGYDVYIFDDVDSVMKSPKSATALIIALGLEEAVPIVNEMVDIIKKGLSDEGRRGRYEELKGELERLKDKKGSQVIMASATAGGGSLTAKLILSLLGLSPASAPPAIRYVDDVKMFHEDPVEGAAEVVRYFTSEGLKGIVFVHEGFPIEEVERALRERGVAAEVVKSGKLKALKKLEKGELDAVVAYSSRYGVAARGIDMPDVIRFAVFVRPPFKKFDLERGLNNPLTLLRVMKKLEMKEDTVKLFKMLSKLSEVELALLRRAMEEGGELEGFLGDALSALKEMKGKVLERLKGEKVVDKGFVVKDGKVFLLDPKTYLQASGRTSRLTPKGMTHGVSVVVYDDEDLMKAFEESLKDRVEFKEELVTPKGPKPVKAKNVLIVVESPTKAKTFARIMGGGGKVEVGGVAAHLAVHEFGGEALFAFIVATKGHLFDVTLDEVGTYGVELGEPVRVYYAPINRCRRCNLAWASSDPRCPKCGLPAESSSKVVEALRRLATVVDEVYLATDPDEEGEKIAWDVMAMIYPFNSNIKRMKYYEVTLRGLHEALSFLTTVDEGTVRSQIVRRLDDRLVGFAVSERLKAAFGDPNHGLGRVQGPVLKFVVERAKARKASAGYSVTLHLSNGDTLRLFVKTKEEALKLASVEEVKILKVEEEVEELKPLPPYTTDTMLEDASKLGLDPSRAMRVAQDLFEMGFITYHRTDSTRVSDAGIAVAREWITSKFEGLFAPRRWGEGGAHEAIRPTRPLSAEDLKLDFALNGMSFEALRLYDMIFRRFMASQMKEAKVRKVKVVYEVAGKRVESAWVAEILEPGWTSVWNIKTKDIKLEKVAKVVSSEVRRASLVQLPKVFEVIRWMKERGVGRPSTYAKTVENLRRHGYVVITPNNYVVSTKKGVAVAEYVERNFPELAEAEYTRRLEEAMELAKSDFWGAFNNTLRAFRALASLES
(597) Reverse gyrase [Ignisphaera aggregans DSM 17230]
6
MSGINIVFDLGGKGDEELLKIPRGIYLGLCINCGGPIEDNRIIYRNACSKCMNSKDLVEVRDLEELAKHVTSLNPNGRLNYILTLNKFVKEFEEFFQKSIGSKPWSLEISWALRVAQHQSFAMIAPTGVGKTTFGLVMTLFLSYKYGKKVYIIVPTTVLVEEYEKRLWQFSEKLGITLKIIAASSKIHGKRKIELEESIASGSFDILITTSAFLQRNFNDVFKKMLSNNIKMDLIFVDDVDAIIKGSKAIDMVLQLLGFSEEDISNGYKMIDLRRRLLQCENARESSRCYIDGKPIDVIYEELQKKVLEKRERCGILIVASATGRARGKRIKLFRELLGFSIGTAIEVNRNVVDAYIPIDNPAEIIDRLVSIIKILGSGGLIYVPLDLGQEYAVKLATELNSRGIRAGVVISGKSEDLKKFIENELDVVVGVATYYGLLVRGIDIPERIRYAIFVGVPRHKISLTRIEYYPQTLLRLLSVLVDVVEDQMKDRVLRNIAYLRRILRRISPNRIFDIVERLKKGEKVEDELAGIITNAYKLVNELLSDSKIIDRLKKHERVSIIEEEGQLYILIPDAPTYIQASGRTSRLFMGGITRGLSIIFVDDTRLLRGLEERIRVYIDDFRFQSFNEINLEEILKQIDEDRRIVNLIKRGLLEEVIHIPKFSFSRSILFIVESPNKARTIASFFGRPTIREIDGLRVYEVDIGNAHLLIASSGGHVFDIVEEELSENNIYGVQRTVENGKQLFLPIYGYLKRCSVCGAQFVKGTVCPICGSTRIRSSEKIINALQKIALEVDEVIIATDPDSEGEKIGYDMAIALAPYAKIIRRAEFHEVTRKAILSSLYNPRGLKLSLIEAQIVRRIEDRWLGFALSDYVTKRFKELKLESREGRLSAGRVQTPVLGRVIEIYINRLRTQRKYKIFSIGNISLEIPVEDLKKIFGDELKRISKERVEIVLKLLSHEIVNLNPMPPFTTDELIVEAQRQLGIDAVETMRIAQDLFELGFITYHRTDSTRISSTGISIAHEYLLNKFGDLGKELFVPRTWGEGGAHEAIRPTRAMDVDMIQEIIAEQLIELPIRLTNRHLRIYDIIFRRFIASQMKSAKVERNRFEAILKIDGIEVAKQHIEIISNIVEPGYTLIYMPFKTVFLPHGSIALKPLHIKTAILSDVKLPTQGDLVKWMKDVGIGRPSTYAKIVEILLRRGYTFRHRKGSVLIPSITGIIIYNILAGTMLPSIEVDEEEFINILQKHPSIRKYNPEALRQTLAEILRNLSIGIRNMVSVERTRMLYNKMQEIEEGRLSYINVLSELFREMCSNVINMISSEAIEICKS
(1762) DNA topoisomerase [Ignisphaera aggregans DSM 17230]
3
MNIKDYILVIAEKPKSAEKIAYALGNPKKYRINGVPVWFVMRGTSRFVIAPAAGHLYTLHTESKGFPVFDYKWVPKYIVEPESIFTRKYLNVLSMLAKNAKEYINACDYDIEGSLIGYMIIKNIGDIKRSKRAKFSSLTASEIVRAFNNLLPLDYNMIEAGYCRHILDWLWGINVSRMLMSIYRSVFNEKRILSAGRVQSPTLSYVVNIDLQRKTHVPVPYAYPSIKIFIDNKIFKLIPIDSPFNSLSDAKEYLENIKRDPRATVLDIIVRDERIEPPHPFNLPDLQSEAHRIYGFTPYKTQKLAEDLYLEALISYPRTNSQKLPPTLNNREILEKLSQNIVYRTLVKTLLAETRGILRPNNGPKEDPAHPAIYPTGEGTLKGLSKDHIKLYDLIVRRYLATFANPAVVQYVRIEFIVHGRRYYLSTNIVRSRGWLQYYPYIHFNGEEISLKLLRKGLQIPIHEAKIVIHFTKPPHLPSKISLVKWMEEKGIGTEATRAEIVETLFKRGYLYMRGRGSGVSELGILISFLLKDYVEELISVELTRKFEERLNMILNMKAKCDDIVEEAKEMLLKYINRVKSLDIQTLRAEISKYIEMSDNNGRRCMICKRSVYANNLCIFHNIALENIRSAYETWRKFGFSWTQYLEKLLKLKSTGSYVKEVCRHLIKQGEF
(919) Reverse gyrase [Ignisphaera aggregans DSM 17230]
6
MTLAIYRHGCPYCGSSIYVGEDSWSCENCEMINRFRHGNSYVDVWFKEIRDFIEFFRMATGFSPWSLQTYWIKRLLSGESFAMVAPTGIGKSTLLGVYALYRAYFYRSKIYIITPTREIAKQFYSKISEYLRTISKNFHGADKLRIIFYDSSSKNHKDILKLINENMFDILITSSSFLSRHHVIVDSSKIDIVIADDLDSIMRNSKSVDRVLKILGFDEKIVNLAMELVKLKQSFYVAKLAKSQESVENIRRKIIEMEAILKNEVAKRNTQLVVASATGRSAGMKALILKELLGFDSGAIFEYWRNIVDIYSQIDDKMMIYIKEIIEKMKSGIIFVSSPYKDYIDVIVKKLMDMNIKVAVVKSGNKAVDKFRRGEVDVLIGSSSYYGILVRGLDEPQRIKFVIFIGLPQIMKELWNSLSNIRLLYMIAKCLNEQGIDLSNDIKTLINIIQSSSPAQLILLSKALNGREYPNDLRDKVEELAKIRDRVYEEAKKFLDTNGKLVINNYGILVKLGHRYVILKPDPYTYIQASGRCSRLFNGIKTFGVSIVFENYKELIELMEKKMKRFVDGFRFINLSDADIDEYVLRAESTRSLNFSGDGTIDIRKGISTALIIVESPTKAKTIASMFGKPAKKVYGNVIVYESIIPISRDKVYVSMIVATLGHITDLVTDEGLYGVRVNNDRYIPIYDFITKCRRCGAQIVGIYDECPYCNSIDVQSSNTIYNVLKKLALEVDNIFIATDPDTEGEKIAFDIYNLLYPINKNLFRIEFREITKNAVLEALKNPRRIDIKRVKAQMTRRIIDRWIGFELSMVLQDKFNKPWLGAGRVQSPVLLWVARRYKEYIDSIGYILYCDLYGYKIKIYLGNNVDRNYVEKIMDRISNEGLEVKDVEIIERTIQPPPPFTTDSLLYEASNKYGYSASKIMAIAQSLFEQGLITYHRTDSTRISSLGLSIAREALAKENLLEYYVPRQWNVENNAEDAHEAIRPTNPINADELIELIMRGELGIITRISDDHLKIYDLIYRRFLASQMKPARVLVLRANIGIDKYFTNIEAIIDIIEKGFMSIYPLKIYPDLRNLEKTTFIKPNKIFVKKGSAIGLYRVADLIRMLKEKGIGRPSTYAKAIDNNIRHGYIILSKKVKATIPTKLGKEISEIIEQRYINLVGDKVTYELEREIDLIERGLRDMNYVLNRVRQAIDIIINTEGNNIIQLFSDTETVNISDNRVELISSE
(363) DNA topoisomerase [Pyrolobus fumarii 1A]
3
MVAGGCRPPRGYGLIIAEKPKAAAKIAEALGGRYARRCTAYGVPYWVLRVDGRLFVVAPAAGHLYGLYTDERGFPVFTYRWVPLDVAEGAKHARKFLALLATLCRDASIYINACDYDVEGSVIGYMIIRNLGDVRRAYRMKFSALTPTDIRRAFRRLEPLDWPMIEAGLARHELDWLWGINVSRALMEAVKLVTGKKVVLSAGRVQSPTLVEAAKREARRRLHVPYPRFNVQVWLAGREGRLKLTIASREKLIEAKRIADRVAARGYAFVSSVAGRREYVKPPPAFNLSDLQMEAARLYGYSPAFTQEIAEQLYLDGLISYPRTNSQKLPHTLDFRGILEGLASIPAYTQLVKRLLLETRGVLRPVQGPKEDPAHPAIHPTGAVPRRKLNRAEERIYDLIVRRFLAAFSKPAVVERVTATLDFGVVRVNVSGTRVLEEGWYVYYPFSRPKDDIPRVSRGERLRVERVVVETVYTEPPEAYTKAKLVRWMEEVGIGTEATRARIVETLFDRGYLRLSGGYVTVTDLGFAVAEVLEKFFPKLTSVAMTREFERLLEDIRRGIRRRAEVVEEAKRVLSLLLEDYKKRAMRDAGLMLAKSLRLVEAERPCVICGRESVDGRLCRFHLEALEALKRGFVEWRRRLGGIGWEEYLERVASLRETGMWVRDVAKYLLETGLAP
(1020) Reverse gyrase [Pyrolobus fumarii 1A]
6
MAGDGWRLHGVYWYACPHCGGPIGDDRLYHRLPCARCLPDDRLSLLEPNPDGTYDPRRVAELLEPREDSPYLALAELEREVERAEAFFEKAMGSRFWSVQRTWLRRVLRGKSFAAIAPTGIGKTTFGTFTAVYLAATRGVKSYIVVPTTPLVEQVEERARRFAEAIDPGVRIVAIHSRLPRKELKRRMDAYRNCDFDVLITTSSFMLRHVDEIISVLEGKCGQRFYLVFVDDVDSVLKSSKSVDAVLKIVGFSDEDIKAGWELLKLRREIARLSARARSKGEIDPRLAELIEKARELEKRFEGKRRCVCGRCNHRDCVSVLVVSSATGRPRGTRVRLFSVLLGFEAGSRPELYRNIVDTYVKPRDGIEEEVVRLVKRLGDGGLVYVPVDKGASYAERLAQLLSDAGVRAEPFTARNPDALERFRRGETQVLVGVAIYYGVAVRGLDLPERIRYAVFAGVPRHKFSARFEDPHPTNIMRVLGLLAEHAPDDVRSEAEKLLARLRRIVRRLSAAALQKLAEELRSGEVSSDAARLFQEALRFVREALSRSDVWEALEKAPDVAIVREGDKSYIMIPDVATYIQASGRTSRLYAGGITKGLSVIVVDDDRLLEGLRRRLRWYIGEAEIRPLEEVDLDKLLREIDEDRRRVRDVLSGRVKPEYLELVKTALLIVESPNKARTIARFFGRPSVREIAGLRAYEVSTGDYVLTIVASGGHIYDLAKTYYPLDVIPSWWLREFNFEGRVASIDEFVTGFDWSSAENKHGVFVAKRGSVRYLPVYTPLVRCPDCGFQSAANPSLAPNEEQTIRDVIKARLGKDVDPFDEKSLPRYCPRCGSPSVRTSLPVIEALRELASEVDMVMIGTDPDTEGEKIGWDVAALIAPFANKLVRVEFHEVTRKAILEAIRNPRPFNPRLVEAQTVRRVEDRWIGFTLSPILWRDFWLNYYCPRMTERLRKRLEAIRAKIRALRRRGMRVPDELKKRMERIEALLRACEGPNRNLSAGRVQTPVLGWVIDRWSRFSGEQKACAARRGLPSEECPRLQVTVSSDGVRVVFEAPGSLAPRLRPGTLVELVEVGREVVEENPLPPYTTDTMLADAWDKLRLPAPVAMQLAQELFEMGFITYHRTDSTRVSDAGIAVAREYIRQKWGEEGLEKLFRPRRWEPPRLIGVEAAHEAIRPTRPIDADTLRRLIEEGVIETPRPLTKRHLALYDLIFRRFIASQMAPARVELQVLEVRLGGEKLVEVKRRAKIVEEGFLMIYKPWEVEGEAPAGEYRVVSVRGRPETWPLTQAEVVRMMKERKIGRPSTYARIVETLHQRKYVKTLPKTGWLMPMPRGRLVYKYLAEELGSKIPVVRNMISEERTRELLEQMDLVEEGKVDYQVLLDEVYRELLEVEKALKELTGGTPTPPK
(1324) Reverse gyrase [Pyrolobus fumarii 1A]
6
MAKLTLLYEAGCPNCRGRIDEERLIKGLPCWECLPLLPEAERYLSGLDWRERVLAVARLLEEHGKLEGWAWLAREEDELSIFERFFERATGSRPWSVQRQWARRLLRRESFAITAPTGTGKTTLLAVYALYSAVNGSRVYYLLPTSSLAKQVAERLQLLAHNAAVRKRIVYYHSLLRASEKRAQLEAIENGEYDILVTTTAFLSRRWGLLERTMFDTIIVDDVDAILRDSVNVERILMLLGAKPDEIRAATRLVKLSLRVRANPALARRYASEIEELKRVVNGVAGRLGQLVVASATGRARGFKRLVLGKLLGLSVGSIAGYARNIAEYKLLASSPEDAIEKLVETVAKMGPGGLVFVAKPLGVETAKLVVNRLGERGVRAGLAIAGKRVIEKFERGEYDVLVGVASYYGVMVRGLDMPYRVAYALFLEPPFNRTPIEKALQSPRRILALAKALDVEGYREYARILSKMTPDEVELLRAVLQGRLEAGGRLAEAAEKARSLASAILEKLRSVTSEVPAGYSILTVSSSGAYVATPDPYTYIQASGRTSRLIKGYMTRGVVIVVSSAPLLLERFEDRLARLLAGFELREYNEKEVLEELEKAWESRRAPAVSRSALRMNIETSLVIVESPTKARLIAGFWGKPARKEYDGVNVYETVAYNPKSGKTHVMLIVSVKGHVYDLTEEPVGKHGVILEGSDVKPVYAPIVRCRDCGAQHAIVAEQCPECNSVNIEDKRRIIELLRKLAPLVDTVYIATDPDYEGEKIAWDIYTLLKPYAKNIKRIEFHEVTKKAILEALANPRDVNRRLVEAQVVRRVEDRWIGFELSQHLWKVFNARWLGAGRVQTPALGFLVERLEEWKKGRCYALIARLPWGRVKLCYPDSRTAREALREALEKGVEVEILEANIVSLTPPPPYTTETLLYDASRLLGYTAEKTMRLAQELFENGLITYHRTDSTRVSDAGIAIAKSYMQRRGHAKLLMPRHWGEGGAHEAIRPTMPLDADELRDAIAEGEVRIVTRLRESHYKLYSLIFARFMASQSIPARVERVRLRVTVGNVSVEDVVARKVIEAGFLTFYPHVIPVYNVQEGRVKPMGARIVRTSTVRLYTHGELVMEMKRSGIGRPSTYAKIIEALKRHGYVVESRYRKYLVPTSMGRRVYQYLVTEFRPLVSLERTRLVESLMDSVASGEAEACRVLLELLEEVEGMVARVEAGRGAGLGENLAA
(1174) Reverse gyrase [Thermosphaera aggregans DSM 11486]
6
MLTYVLNPLYRSSCPVCGGDLTSRDIEEYGKCSKCRSRLDSSLNVFTLNKIIEDEVEDFEEFFKTATKGLTPWGAQKTWIKRILSGENTVLIAPTGMGKTTLLVAYALFASSRGKKILYITPTRALGKQIHARISGDAGSEHSVFYDSGLSKRRKQTLLEKIGKGDFKILVITNSFLGRNFDLLSKHEFDIIIVDDVDSLLRSEKNILRLLLLLGFNEEVVQLAKKRLQLLWRLMVSKSLNNEESYYSIVKEYLDLDAKIEASLKTLKRRQLIVASATGRIKGLMGRILKDLLQVDVSGITIYGRDVTDSYFLRSLDEASRELAALVKTLGPGCVIYVSPRHPFKQQLVKLSEDLRSILEREGFKIADATPANVLKLVSRQVDVLIGSASYYGSGVRGIDAPQSIKYVVFLGTPVFTVSLDSFLSNPNMLARILIELAEKTGIKSLREKAYTVRRLVYYLSPGETRLLRNVLKGKIPEEAVKPHEKLYSKYVELKTLYSETIREVEKYLDVNTVLEAGSITLLKSRDGYVALIPDAMTYIQASGRVSRLYGGRMTHGLSLILETPLLSNLVKGLEMKLKLINKDLGFRELEELDLSVEKEMAESTRTRSGEWLLKYRSVLIVVESPTKAKTIARFFGKPVSRRIGDVNVYEIPVKIGEEIVDLNITATRGHLYDLTTDPYTDNYGIIVETGLVTPVYETIKRCRVCGTQFTHEASCPRCGSGVFSDQKAIVNALRKLASEVDEVLIATDPDIEGEKIAYDVYLAVLPVNSNVWRIELHEITLQEFLKSIERKRSVDRNKVLAEIYRRSLDRLVGFSLSQDLWSRFGKRYLGAGRVQTPVLGMIIQRYREYVEGRCRKIELSLGSPLNTKYSVCVDNNSSLVDEARRAGKILLRKEGEEVVEIAPKPPYTTDEFLVDAARRGIPVSLAMKIAQELFEAGLITYHRTDSKYVSATGVSIASKYLASKNLRNLFKPSHWGEPGAHEAIRPVYPYDADDLMKAFTEGLIPLTIPLTGLHYSLYDMIFKRFIASQMKPFKAVKARFSLWVNGISLGTMEVYTRIVEEGFNAVAGIKTHEALGSVEEAEVPVKEVKTSISSRTFLYSEGDLVALMKKTGIGRPSTYSKIISSIERHGYIVKSRKKLKLIPTKTGVMVYDYVSTAYPDLTSIELTRRMEDLIDEISMGRLNAAEVIMDLIQSLSTRSLITVKTVNTFSSQL
(625) DNA topoisomerase [Thermosphaera aggregans DSM 11486]
3
MNNIYSTIGRGPGFTSIWDLKGKVLVIAEKPKAARKIAEALSQRYFVRNINDVTYFEIRDGPRQIIVASSVGHLYGLTTQEEGYPVYTYQWVPLYVVEKKKAHSYNYLEALRKLCTTSNYFVNACDYDIEGSVIGYLIIKFNGDPGRAYRAKFSSLTLSELREAFRRLTQLDYEMIEAGLCRHELDWLWGINVSRAIMRTVESFSKKKIILSAGRVQTPTLKYVSDIEKERNLFIPIPVYSVVPTIVKDGVKITLELINSPIRTKKDAYALAERIRREGFLTVESYVEHTTSVAPPPPFNLGDLQEEAARIYGYSPSKTQSIAEQLYLDALISYPRTNSQKLPSGLDFKSLLTKISQISNYSALVSDLLKETKGYLKPVEGDKEDPAHPAIYPTGVRPVKLSSEQWAVYDLIVRRFLAAFAGNAIIYRSTAKFALPGENIVFQATGQGIEDLGWYKYYPFHKPSVKVLPRFRNGERVEVVEVSVKTAYTRPPQRISKIGMLRWMESVEIGTEATRATIIEKLFERKYLVNTSRGVAVTDLGLGIVETLEIFFPELVKVELTRHFEKLMNDIKKGVVKREQVITEARNTLDMLIKKFNEKKETVGQILSSRLGIYTPPNKCAICNREEFSNGLCTYHYKANEQINKVYEEWKEREGVSFKEYLERIKKLKSTGKWVIEVIEHFYGGK
(221) Reverse gyrase [Thermosphaera aggregans DSM 11486]
6
MSNLLNPYGFYRHACPNCGGEISDHRLFYKAPCEKCLSEGDFKKTLKRIRSEGLRDYKSIIEAYYKDLKNPEGLRQLLDEEVALEDFEEFFERATRGNKLWSAQRTWARRVLKKKSFSIIAPTGTGKTVFSLVISLYTVAKSQRGDRRRVYLVFPTLPLLLQAESKVKHFATNAGLKICEDRAEESCIRILVAHGRSDKKSKEELMEQVRNGDFDILLSTSAFFHRNFELLKNKDFALIVMDDVDAVLKSGKAIRKLLNLVNVTDDAINDGLNLIKLRQRIVFSSGEEKEKLSAEIEELEKKIARVKSEIKTTLVVNSATGRPRGIYPKLFKVFLDFEAGSKPEAIRNIVDAYIEADDPENALLEIASKLKDGFLVFVPVDRGVEYADKIAELLKAHGLKSESFHAKKKIDVLNDFARGELNCLVGVATYYGVMVRGIDLPERVKYVIFLGVPRHKFSTALEEISPTDLLRIISVLRDIAPEESKRELESLVGRLSNRLKRISQGALFKLREDFAKRLKGEHVEETVLIKELLRAYELARELLRDEEIWRKLSNLGDVGLLWENGRQYLLIPDVATYIQASGRCSRLYPGGITKGLSVIIVDDKRLLNGLNKRLRWIFEGVSIANLRELELEKLITEIEQERVIVGKILRNEYRPEGQVDLIKSALLIVESPNKAKTIANFFGKPSVRVLGKSLQAYEVTIGDYVLSIVASAGHVYDLVVDLQENYGVRRVGSRFIPVYTDIKKCVNGHQFVDETDKCPRCGTSRVVRKADIVSALKELAREVDLVLIGTDPDSEGEKIGWDLKVLLEPYAREVRRVEFHEVTRRAILEAIRNPRSFDTRLVGAQIVRRVEDRWIGFSLSEIVQKYAWTSYCFENLKDKGHDCCRENRNLSAGRVQTPVLGYIIKRYRDKEDKSLYKYRLLAEKDGEKISFTIDRAQAVNAGLVSILEKNNKRRKKDKNYPPLVIKERELIVEAKNPPPPFSTDALLEEASKSLGLATTRTMEIAQDLFEMGLITYHRTDSTRISEAGLTVARQYLEERYGDKYRDVFQPRTWGEGGAHEAIRPTRPIDADRLAELVREGVIVLTGRLTRQHILVYDLIFRRFIASQMKPAKIGKQVLTVSINGVEAVVERVVEVVEKGYLEVYQDVKLETRITEGEGRITEVVEVKPPMARYHDVIRWMKENGIGRPSTYAKIIQTLLDRRYVDVTKKHKALRPTERGIFIYRFLDEKFKEVVSVETTRRLEKDMSDIEEGRVEHMKILEKLYNELREKILDNPIIKELEDEYSERCGRKSDAA
(1831) Reverse gyrase 2 [Aeropyrum pernix K1]
6
MPGGVNAVYMGLCYNCGGNIDEDRLEKGLPCARCLPSPPRRATPLTVYRALKKAGTLGAYSWEYLSIREVERFEAYFAAKSGSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYVAAVKRGRVLYLVPTENLVRQVYAKLDQVEPGIATAYYSRMPAKARESSLEKIASGGARLIVATTGFLSRRFDLLHPQYKFDLAIVDDVDSLLRNSRNVERILLLTGFSEETVEAAHSLVKARLKLYRALHSGASESIVSRLEQEIAQLEARLRLSLSEASPGQLVIASATGRPRGVKHLLFKELLGFEVGGGSDYLRNIVDAYVVDSDPVGRTAEIVSALGDGVIVFVSQRLGKDVARAIAGRLEGMGVSTALALTGARRPVEAFARGEARVLIGMASRYGVIVRGLDLPERSKYAVFLGAPSAKTHLLEALYSPRRMLAFLSIAQEKGVEWAGEAFRRLSRLLEKVIDTSIVSLAARGKLEAQGPAGEAAGIISETAPRLVDWLVAEARLQGGLLRVGGLVVDARGPIPYLVVPDAPTYIQASGRVSRLYRGVMTRGLSIVVDEAPEYVEALGERLKWTTSSRLRPLSEVDMEKLRREIEESRRGKGRRVRVKTTLLVVESPTKARTIAWFWGRPGKRRIGRSVIYEASVSDPETGDVHILQITSTRGHLTDLTTDSVGSKYGVDEDGGGYRAYYSTIKRCLDCGAQHTSSSPFCPRCGSPRQVDSKSVVEILRKLASEVDEIVIATDPDREGEKIAWDVFLAVRPYNPNVRRGRFHEVTPRAVIEALRSGESVEKSLIEAQKVRRIVDRWIGFHLSTHLKLKFSKPWLGAGRVQTPVLGWIVDRYREWQDTRGYLVIFKLSSGGRTSYFTQNRLEVENLKRVEWLEVVDIAGKTEERNPPPPYTTDEYLYDASRKLGLSAGLAMKIAQDLFESGLITYHRTDSTRVSPTGVKLALEYLASRGLEGEAQPRGWGEGGAHEAIRPVRPIDAQDLERAVLSGSIRIPIRLTRLHIRVYDMIFRRFIASQMKPATLDIVEATLQAGETVFNHAGVARVRGGYALVNPPRVEEWLARLSPGDRIDVEDVLVVKSSLKRLYRAGDIVKMMREHGIGRPSTYAKAIEQNRRHGYVIESKKMRYLIPTKTGVSIYDYLSNGFKKLVSVDTTRRLEEALERVEKGVEKPEAVLASVWRMVDEAVSLHAATGDVMGQSEA
(1272) DNA topoisomerase 1 [Aeropyrum pernix K1]
3
MVAEKPKAAAKIAYALSDGRGVLRCSEYGVPYWIVRRDGAAIVVAPSAGHLFGPHTDSRGFPVFDFEWRPIFEFDRGAGYLSKFYRMLSRILPGASLYVNACDYDIEGSVIGFKIIEAFGDVNRARRMKFSTLAPQDIRRAYARMERLDVEMIEAGMARSEMDWLWGINVSRALMEAARRAAGRRVILSAGRVQSPTLVEAYRRWREINLHVPKASVAVKITAEKGGGVFDARPHGWKPQSLETARSIKSELRKNPWLAVEEVRSERSILRPPPAFNLGDLQKEANRILGLPPLRTQSIAEELYLEALISYPRTNSQKLPPSINYRAILDKLAHGPLGREARELLKETGGVLRPVQGSKDDPAHPAIHPTGEKPSQRLSKEHMAVYELIVRRFLAAFSREAIVSKSSVLLRDFQGRVWRAEGLRVEDLGWLKYYHYSTPGEKPMPPLDRGDKARVVRVDVRVEWSQTPVRLDKASLLRWMESVNIGTEGTRARIIETLYKRGYLEGSRKSEVTPLGEAVAVIIQTLFPELSKPDLTRRFESMIEDIRSGRRTRQEVIDMSKKTISKLLESFLDRLDTAVREIGVSLGSVEVEAACHLCGRKAVSAVSGYRLCSHHMEAFDRLRKALPNLASTISSTPREALEAIARGRSRAGAWVRDVAALALRDDGLYKALL
(1407) Reverse gyrase 1 [Aeropyrum pernix K1]
6
MASARAASRGVYRYLCPNCGGPNSEERLSRGLPCPRCLPRLPRKGVSGWTGLARLLRREGTLGAGVKAMASLEEEARSLWRFFEKAVGSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAASLFYACKKGMRSYIVLPTTTLAANVARKLESMVESTGCGRVRLLVIHSKLKTSERREAMERFEKGDFDILVTTAAFARKYADRLSGYRFRLVFVDDVDAVLRSARSVDAILKIVGFDEEAIEKGLEVLRLQREQARLVGLLQSQREEVREEARKKLLEVKRRLERLEAEIEARRGRTASLIVSSATGRPRGARVRLFRVLLNFEAGGRGDIGLRRVIDSYTHPTDGVAEKVVELVRRLGTGGLVYVPIDMGVEYAERLAEELRRAGVKAEAYHAKKPLELLDRFAEGEIDVLVGVANYYGTLVRGLDLPARVRYAVFAGVPRHKFGSDIGDPHPSRLLRLLSILAESRIEEVASAARSHMGRLRRMLRVLSPAALQMIAERVARGEVEGGYDRQVLEAYQFLREALARDDVWESLRELDVGIVREGGRTYILVPDPATYLQASGRTSRLYAGGITLGLSVVVVDNEPVMRGLMKRVSWMAEVDWRRFEDLDLQSILREIDEDREKVRRVVKGLYRGVELVRTALLVVESPNKARTIARFFGQPSVRLLPGGGRVYEVATGDKILMIMASGGHVFDLVVRVDGRDLEAAGGEPEHAIFGVLRYRLGGNGAAAYTPVYTSIKRCLDCGYQFVDEASRCPRCGSELIRNSLSTVEDLRRVAWEADEVYVGTDPDTEGEKIGWDVALALRPYAPDIKRLEFHEVTKKAILEALSNPRSFDDNLVDAQVVRRVEDRWIGFTLSPLLWCDFWPRYCKRVLEEYGEKRPHMDRERCAKYKAYYNLSAGRVQTPTLGWVVDRTLAYRKKVWLYRVVHDSQLLFAVRSDDPEVPESVKRVLDNWVKHHKKTGIEPWLDVKAVVEKEEWTALPPPPPYTTDTMLRDANRLLGLGSAEAMRIAQDLFEWGLITYHRTDSTRVSDRGMQVAREWLETRFGGLAGQLYRPRRWGEGGAHEAIRPVRPIDVERLQLLVEEGVIELPGTLTRRHLRLYDLIFRRFMASQMREADALRVVYRLRVPELDGYTLTLERVVEIGRPGDAEGVTRGFTLVWPYVRPQPRLVEGREAWIRARVEGRQVPKAYPYTEGEIVEEMKTRGIGRPSTYAKIVETLFRRRYVIEVSREEGRGAGFVVATSRGINVYNYLTEELRSADEEEYGGRIAGILRRVPSLVSEDRTRELERQMDMVEKGDASRDDVLESVFNEISDLALLLNIEHPIKHRSRAEGNTQGNTWVSNFVACAVKSPEVSRVWGAGVG
(1348) DNA topoisomerase [Hyperthermus butylicus DSM 5456]
3
MVRAGYCSAGFGYTLVIAEKPKAARKIAEALSDKPIACKLGGIPYWIVTWMGTRYVIVPAAGHLFGLTTDKHGFPVFEYYWAPLWAVDSSSAHTRRFLEAIKKLARHAVRFVNACDYDIEGSVIGYNILRALGVEKRALRAKFSALTRQDVRRAFSRLERLDWDMINAGLARHELDWLWGINISRALMESLRSVTGRSKVLSAGRVQSPTLVEAVSRTIKRNLFVPLPYFTVTATVELGGKARRLQVASFELRSEAQRVARQLRATGYLVVREYSEYVERIPPPYPFNLGDLQVEASRILGFSPYYTQKLAEELYLEGLISYPRTNSQKIPPTIDISAIVQALVRQTRYRELVEYLLRATRGVLRVNNGPKEDPAHPAIHPTGEPPHSGLSKNHLRLYDLIVRRFLASMAPPAVLVRARLILSAEGLGSASITGVRIVSPGWMQIYYWAKPSEEYIPRLYRGQRIQVKSVSVQTSYTQPPELHTKTSLVKWMESKGIGTEATRARIVELLFERGYLRSEGGRVQATELGLTVANILQTYFPDITSVELTRRFEELLEAIRMGKVSKDAVISEARRFLAGILSEFKVKSMHAVGMELAYSLGLLKPPRQCPICGRRAEGEYCSYHEAAIRKIVEAYHEWRRRTGITCREYLEKLAAMRSTGKWVREAAKYLLARNVCPKGLTA
(324) Reverse gyrase [Hyperthermus butylicus DSM 5456]
6
MGELSTDYYERIETIGRLLAENGRLRGYWYLYSSTSQLREFEEFFEKLTGHKLWSAQRTWAKRMLQGESIAIVAPTGVGKTTLLSVYAVYRASQGLKVYYLLPTENLARQVTRKLETLSSRLGGGIRVVSYYSSLPKRAKEESLRTIEERSYDILVTTTAFLSRRWSLIEGIRFDSILVDDVDAVLRNSKNIDKLLQALGFSVEAIEAAYNLVKKKIMATIAKTSGNIKRYEKLLQDIEQLEAILSQELVKTTPGQLVIASATGRAYGLKPKLFRELLGFDIGRVYDYTRSIANLYKIVNDPVAEAVSLVTRMGGGGLVFVAKRFGKNVARRIAEMLNERGIRAAVALAGRRVLDRFASGEYDVLVGVASYYGVIVRGIDMPERIHYTVFVGVPSQAIEAGKALLSPHRIARSAVELSLEGAEELARRLSKLAPNEVTVLRIALERGERLEGRLGEILEMLLETRRKLLHAIEELVSIEGSVAVGGALYRFEDGKLVAILPDAPTYVQASGRASRMYGSAMTHGISIVLDVDEILVRLLAEKLKRFLEDVRFEELSSEKLAKELEKARASRRGGVGKKVDIETCLIVVESPTKAKTIAGFFGRPVRRRIGSVVVYETTFYNPVSGKIHVAAIAATAGHVYDLTIDDEGIYGVELGKNGVSPIYKPIKRCLSCGHQFSSSSQVCPRCGSSNIVSKEDVIGALRQLAIENEVVYIATDPDVEGEKIAYDIYLLLRPYARKIMRIELHEITRSELNRALANPREVDVRLAEAQMVRRIEDRWIGFGLSQHLWQVFGKNWLGAGRVQTPVLGWIIERYSEWRSNLGYNLYIRLPGGPLVKIHYDSASGAREAAAAAENGVRVVSVEEEVVEINPPPPYTTESLIYDASRLYGYPAQKTMRVAQELFEAGLITYHRTDSTHVSGLGQHIARLYLESREDAELLQPRSWGPQGHHEAIRPTRPIDAEALRRMVALGDLRVPVTLRESHYRLYDLIFRRFIASQMKPAKLKRRRIRLEVAGSQVEIEVYTAALREGYHKYYPYPRLHMALDSVKPGDVLRPERILVRRGSTVYLYTHGEIVSLMRERGLGRPSTYAKIIDALERHGYVIESKYRRRLVPTKLGIEVYEYLESRYGSLVSEERTRKLYRDIEEIASGNKSPVEVVNELLAELSELLETSLRQYTGEVKALG
(523) Reverse gyrase [Hyperthermus butylicus DSM 5456]
6
MKNYGGGAAARGVYLYSCPNCGGPVGDDRLSLGLPCPKCLPERTPAESVLDVAEALEKLGRLRRGSELEYYARVEREAREAEALFEKATGSRLWSAQRTWVKRVLKGKSFAAIAPTGVGKTTFGVLMAVYFAWRGEKSYIVVPTTPLVRMVEEKALKLADAAGVPARIIALHGRLPQKVKKELTMRVEEGDFDILITTSQYMIRNAEWLAGLRKRWGKGFRFVFVDDVDAVLKSGKSVDAVLRVVGFTPEEVELGWKLLQLQRQLVVASRRAQEQFLKELARLRQQARRKGKRLSAEEVRRLRRRIFEERLGRLYEELRRVEERLAEARRRAAVLVVSSATGRPRGSRVRLFQALLGFQAGSAGEAIRNIVDAYTYPGPEGIEAKVLELVKRLGDGGLVYVPLDKGAEYAERLAEYLREHGIAAEAFTSRNQAALDRFRAGETKVLVGVAVYYGVAVRGLDLPERIRYAVFAGVPRLKFSARFEDPHPVSILRALAVLAEHAPRDVADRAQALLGRLRAIVRRLSQAALAKIAEELRSETPASEYTRAFVEALEWLRGVLRREDVWEALEAADDIAVVREDGRAYILVPDVATYIQASGRTSRLFAGGITRGLSVVVVDDERLLNGLMRRTRWLVEAEWKRFEELDLPRLLREIDEDRERVRAIIEGRVKPEFMELVKTALLIVESPNKARTIASFFGRPSARQIGPLRVYEVSTGDYVLLVAASGGHVYDLVKPSTPKETVSPDWLLDQLSGSVEGYNWDTARNIHGVLAAEGGERRFLPVYAPLARCLACGHQWTISPEDYNPAEGRGELRCPICGSPLVKSSWDIVEALRDIATEVDVVLVGTDPDTEGEKIGWDIASLIRPAARSIVRIEFHEITRKAIVEALHSLRDFDQRLVEAQIVRRVEDRWIGFTLSPILWTKFWPWYCSWRLKRRLVQGRRMKNLQTALNAMERLASLAEECRRPNYNLSAGRVQTPVLGWIVEHTIGSKYLRIPLYRLQLEHNGSRLEVDVRGDEVSEEIRRALEETHRRLEEALKSHNVLEALEELEKLRRSKRRVILAVNQALREGGAVKARVSKVEEWEEELKPLPPFTTDAMLAEAAARLGIPAPEAMRLAQDLFELGLITYHRTDSTRVSDAGIAVARDYLRYRYGEEKLSEVFQPRRWGTGGAHEAIRPTRPIDAETLRRLVEEGALQLARPLTSRHYRLYDLIFRRFMASQMKPARVRKQKAVVELEFSIPGEKPVRIVREVEKTVEILEPGWLDIYPVVRTEQRLVEGDYRMAGISTRVWSPVQLLTQADVVRMMKERGIGRPSTYAKIIDTLQRRAYVVTSPRRGTMIATSRGIGVYDFLMKRFGSLVSEETTRKLQEIMDRIEEGLANYEDVLSQVLEELRGALEKPESGLTGDEARKLLPV
(164) Reverse gyrase [Acidilobus saccharovorans 345-15]
6
MCPNCGREITADRLEKGLPCAVCLPREPKSGDILEIGLELAKEGKLKGYSSLYLMEKSFRDFSKFFEEKYGFKLSSAQRSWARRLLSEESFSIVAPTGVGKTTLLMAYAAFKVMQEGYKVMYLVPTENLVAQTAGRLASMLGDKVAFYYSSLPKAQRSQMLDKITRGDYSVVVITPGFMVKNFDMLKKQSPFNLMIVDDVDSLLRNSKNIDRALILIGFDEDSIATAFKIVQEKLELVTLEASGRSEERIRQLQSDISSLSLKLSEKVLEGPKGQLVIASATGRPRGVKHLIFRELLGFEIGGGTDYLRNVVDTFLITASPVDSVVSLAKKLGKGGLIFISQAYGKAYVKELMDKLAGAGVKAVQAISNSRRAVEKLSSGEVDVAIGLASRYGALVRGIDLPEVIRYAIFLGTPAIKVELKTALLSPRRLLRALIFLEEKDSSFKEYREKLENLLKNFNVESNILSAAIRGEIEAKGRLEVLRELVLEASAKAVQALSNMIVKDGQVLRIGTMVLRREGPSIWLYSPDAPSYLQASGRTSRLYHGTMTKGLSVIVDNMKELVDAMEDRLRWMSQATFVEFNSVNLEDVTREIEASRSEKGERKQVNIVTELIVVESPTKAKTIANFWGRPAKRSEGRVSIYETTVVDQETGTVHLITITASKGHIYDLVIEGSDEVGNSLFGVRFNNAIQPVYTTIKRCLSCGYQFTENVDRCPRCGSTAIIDSKGIADTLRKLATQVDRVIIMTDPDREGEKIAWDLYLTMRPYNQNIYRSAFHEVTPRAFMEALRLPGSIDVNLVNAQMARRIDDRWIGFVTSQYLWLKMNKNWLGAGRVQTPVLGWIIDRYNEYKEVMGYKVRGLLPSGTPVIFYTKSSEEAEEASKLNVAVAVTEKVWTEDVNPMPPYTTDEMIFDASAKLGYSAELTMKLAQDLFYSGLITYHRTDSTRISEAGMAVAKQYLESHGLAQYYKPRSWGAGGAHEAIRPTRPLNAEEVERAILDGSLRVPMALSGAHYRLYQLIFERFMASQMAPATLEKASVTLRLGNLTQSMEVVIAVVKEGFTAIMRPKLETWVLRETNKEYEVPLTNVVMFKGSLIQPYRSGDLVMLMKKKNIGRPSTYAKVIEANLRHGYAVETKKLKFLIPTRLGIEVYRLLSSSPFSDMLNEEASRRLEESLDAIESGSQDAGSFIMSVREELFRKLSEANLRLR
(1265) DNA topoisomerase [Acidilobus saccharovorans 345-15]
3
MRSSRDCNIPQYYDVIIAEKPKAADKIAHALGSPFRCAIGRVPIYILNVNGTNIVVVSSAGHMFGPSTGVEGLPVTMIRWEPLWRFDRRSKYLRPYYEVLSRLVPKARYFINACDYDIEGSTIGYKIIEAFGDKSRAKRMKFSSLTAAELRQAFRRLQPLDVNNAMAGIARAELDWLWGINISRLLMKSYREVTGERLSLSAGRVQTPTLAEAIRRWVKINTHVPIPQPSLTARLLHKGVEFTAYPLGWSVSTVKEAREVAKEVKEGMYMEVISLSRASESVRPPPPFNLTDLQKEAARIYGLSPYKTQEVAEDLYLAALISYPRTNSEKLPPTLNYREVLDSIGRQPKYRGLVGDLLRETGGVLRPREGPADDPAHPAIYPTGEQPTRLDRVHETVYDLIVRRFMAAFAPPATLSTVSAVLTDVKARRWEARGLNVAERGWLKYYPFHKFDESQLPTLNRGDRPLVRSITVKVSWSGPGLRLSRLSLLEWMEANDLGTKGTRARIIETLYKRGFITSRGSHAEITNLGYAVYKVLSEVAPELMSVSLTRDFERMLDEISMGKASREEVVSRAKKYISELVERQLNSNNIKVMGTYLAEFIGKVRPRSRCAICGRPTDGQSLCELHLAAKSNLEKSIDEVARRLGVSKEEALRRISNNRLAGKWVRDVAALMISGKERP
(85) DNA topoisomerase [Desulfurococcus kamchatkensis 1221n]
3
MVSKSIRIWDLKGRILVIAEKPKAAKKIASALSPTHNAKRIGSITIYEVDSYSSSIIIASSVGHLYQLHTSLRGYPVYSYEWIPLHLTDPSKKYIREYLEVLGKLCRGVDYYVNACDYDIEGSVIGYLIIKFNGDERKAFRARFSSLTIEELRKAFNNLTRLDYEMIEAGLCRHELDWIWGINVSRALMKAVEDAVGERIILSAGRVQTPTLKYVVDKVVERNLFIPLPQYNINITVEKNGEKIRLEYTGNPVEKERDARDIVEKIRGYKYLIVSKVEKKHHILHPPPPFNLGDLQKEAARLYGFSPAETQSIAEQLYLDALISYPRTNSQKLPPTLDYRRILENISSIKSYRNLVESLISETKGVLTPVEGEKEDPAHPAIYPTGVVPGRLTEKQWAIYDLIVKRFLAVFAPPAKIVYYVVKATTPSHEYVFETKGQVIEEYGWLKYYNFHNYHAGKIPVLKEGELLNIVKATASESYTKPPKRLTKTDLLRWMESVEIGTEATRAQIIEKLFERKYLYQHQKSSGIDVSEIGFGVVEILEKFFPDLLSVELTRKFEKEMDSIRSGVKRRSEVLEEARRVLTELLGKFDRNRIEAGKQLALRLKIIQNTRKCRVSSCYREGVVNGLCSHHANAVKLVREYYGEWSRRKDITFNEYIDKLRKSKLTGKWVKEVIESELT
(848) Reverse gyrase [Desulfurococcus kamchatkensis 1221n]
6
MPGAFNPLYKGFCPVCGGDILSSEVELRGFCSRCANSGLTSILRDIASSGLGDFEEFFRRASNGLSVWGAQKIWAKRLVSGENTVLIAPTGMGKTTLLIIYSLYAARRGKRVVYITPTRTLLTQIHRRLVEAAERTGINGVNLIAYDSSMSKKKREEVLSRIEKGEYSILVATNGFLSRKSELLSRSRPDIVIADDVDSVVRSEKNVLRLLRILGYSDEVIELAKKRISLLWRLMVNKAFNNNDKYAELVKEYIEVDSLIEKTLSSTRHAQFIVASATGRMKGLMGRILKELLHVDISGVTIYGRDVTDAYMLIKPGELHGELVRIIEKLGPGGIIYIAPHHPFKNMLKEELDKAVNILADKGFRIGDATPGNVARLIKGELDILTGSASYYGSSVRGIDAPEAIRYVVFIGSPVFATSLESLLANPGMMIRVLLELVDSNDARNRVLELRRLLYTLTPGEVRLVKLALTGKILEEALQASEKLYSKYQVIKQYYRETLERTRSILDEKGIMDIGTLTLVRAGGDYYALIPDVMTYIQASGRTSRLYGSRMTHGLSIVFEYRALYNTVKGLEARLKGLNKELVFIDLASVDLDSEIKAIESSRRNNDSSPGMSYRSILVVVESPTKAKTIARFFGKPVARKLGDVTVYEIPVKIGGEIIHLNIVPTRGHIFDLTTGEEGYYGVVIADNRVTPVYEYIKKCRLCGTQFTTGDHCPRCGSRLFSDSRTIVAALRKIAGEVDEVYIATDPDIEGEKIAYDVYLAVKYYNEKVWRIELHEITLQEFLKAINNKRGINQRLVEGEIYRRVLDRLVGFKLSQELQGIYGLRFLGAGRVQTPTLGLVIDRYEEYMRNKCKKIRFKLGSPLNIIYSVFMGKNSEVIRELKTAKMLKLVRVGREIVTITPKPPYTTDELLSDAAKLNLHTGIVMSIAQQLFEAGLITYHRTDSHYVSNTGIGIAMKYIEGKKLEDYARPSHWGSPGTHEAIRPVYPYDLDDLLKAVSEGVINTVIPLTGMHLKLYDLIFKRFISSQLKPFKAVKSIYAVYFGEFKLGEIELLTNIVEEGFNVFEKTRVYKELDAVESIEVPVEEISVVDSSKSPLFTEGELVSLMKKLGLGRPSTYSKIIESIKRHGYVFVSKKRLKLIPSKRGIEVYGYLRDRYPELVSIEATRRLEESIDKIINGEVDALVYLTDIGSRLNMFHSINMVNRGDFASTSS
(709) Reverse gyrase [Desulfurococcus kamchatkensis 1221n]
6
MINLKTLLENFREFKPHGIYRHACPNCGGPIDDYRLIFKAPCSKCLNEARFKAVIKDLNGEITRFQLLKLYYDKLNKKLKKSGDLKKLMDNERMLNDFEDFFEKAIGFKMWSAQRMWARRILKGLSFSIVAPTGMGKTVFSLIATLYLVSHSRSKNREQRFYLVFPTTPLLLQAERKIKDFSRNLGINVCMDDNWGSNCLRILCIHGQQGKKEKEAALTRLKEGDFDILLTTSKFMHKYYELLKNKNFKLIVMDDVDAVLKSGKAIRRVLNIIGIEDEYIDKALTLIKARSKLAVLSSEEKSKLEKEVESLEKEISTVKQNINTILLVNTATGRPRGIYPKLFKIFMNFEAGSKPEAIRNIVDTYIESIRDIEEKMVELALKLRDGLLIFVPVDRGVEYAEKIASLLKEKGLNAEAFHSGKPAKLLDAFARGEINILVGVATYYGVMVRGIDLPERVKYIMFIGVPRHKFTPELEELSPRDLLRILSVLRDASEGERKEAIDRLIGRLSSRIRRMSPGALMMIREELAKKLRGEPVEETPFLRDAMEAYKIIKEELSKDETWHKISSLGDIGVIREGNKYYMLIPDVATYIQASGRASRLYPGGITRGLSITLVDDKRLLNGLVKRMRWIFEDFNMVSLDQVNLEELTRQIEEERRRVAEVIREGIKTTTQVEPVKTALMIVESPNKAKTIANFFGKPSIRVVKDVLQAYEVTVGNYVLSIVASAGHVYDLITDNPGESMGENLYGVLKIENRFIPVYTDIKKCSNGHQFTDEVIDNTNECPKCRINGKVSHVTRKLDIVKALRELAEEVDVVLIGTDPDAEGEKIAWDLRVLLEPYASDIKRIEFHEVTRKAILNALKNPRDFDLKLVESQIVRRIDDRWLGFSLSEKVQKYAWLKYCSEYLKNKTVKEEKDDSELHEFDCCTQNRNLSAGRVQTPVLEYIVKETEERRKPERWSYRIKIYVEDVGDFVEVTIPYIDAEELGVIKSLNKKKLLPVEIIVIGEDVEEVNPLPPFTTDALLEEASRSLRLSAVRAMEIAQNLFETGLITYHRTDSTRVSDTGISIARQYLEEKYGEKAQFYFKARMWGEGGAHEAIRPTRPIDADRLLELIKEGVLTLSVKFTKDHIRLYDLIFRRFIASQMRPAKLRKLKFKVVIKNREYYSEVYTEAVEKGYLEVYKNIELVQGIRLKPSEPGGRINGKIHEGEVIKPPMLRFHDVVRWMKENGIGRPSTYAKIIQTIIDRRYVIVSGETKALIPVERGRYVLKFLKDHYGDIVSVDTTRRLEDLMEKISRGERDYQEVLEEIYREVKNIVLENKDINDSLEKEYNERCASTT
(1360) DNA topoisomerase type IA central domain protein [Caldivirga maquilingensis IC-167]
3
MDKLIVAEKNSVAKAIAQYLAEGGYTLRRIGIVPVYFFKVNGEYWASMGLRGHILDFDFEHSYNNWNRVEPGKLLDLEPVMVIRGWDRPYVTALVELSKQAREIILALDSDVEGEAIAYEVMLVTRLRKPTLRFRRALFSAVTRDDIRRAFSKLTTINVNLARKVFTRMVIDLKYGATFTRLLTLSAKSSKAPLNRGEFLSYGPCQTPVLNLVVQRALERENFKPEVYYKIKLIIEANGELIELESIDKFKNLKEAQEALSRVKAGKAVVKNIEAKRVHVNPPKPLETVELERRASRFLNIRSKQTLDAAEELYRQGYISYPRTETNIYPPTLDLRGILRNLTSTSTYGQYARHLLAGELRPTAGKDNDNAHPPIHPVKAADKPELMARFRDFKYWLIYDLVVRHFLATLSPPALIEEQRLTVDAGGVLFEASGLRIINDGYFTIYPFERPRANPLPLSALRIGMQVTVKDAKVVKRKTTPPPYLSESELLRLMRKYGIGTDATMQDHIHTNVKRRYFKIIKGQCVPTPLGKALITSLSKYAPTLIDPNFRSRMESMLSLIGSGKEMPDSVRRRLEEEAARVYTSMKPNSNQLGEELAKALRSMVNEKGA
(4) Reverse gyrase [Caldivirga maquilingensis IC-167]
6
MRDNKGDGGSGEPLVLYHGMCPNCGGPVTSDRLRDGLPCHVCLPEGSRLRAASLRVVLSELNREGRLVRLRDIFNYLMKYDEFSELFRKATGTSMWGAQRFWAKRLIKGKSFAIIAPTGSGKTTFGLVASIYVASKGGRVLMVFPTSTLAYQVYKRALTYRDSAAVNIKVITYNGLLSEKDKSEVLNAIKAGDFNILIVTNAFLPKGMEILSKYRFDLVFVDDVDSVMKASSRNIERLLQLLGVPREAIDKALEIAKISDFKEREGKVSELRRILEGRRIGSLIVSGMLTRTRRTARAALFREILGFDVGGRAEGLRNVVDLYIKPKGDLKVIILDLIRRLGDGGIIYVPTDLGREFAEELSKFLNDNGINAGLYLKPKRKLIEGFEDGSIPVLIGLATSRSALVRGIDLPHRIRYVVFAGVPKIRFRLSLKEFNPGRYIMLLSSLRVIAPSEYKTRIDKTVSSLRNIMNLSQDRINKIIEAIERGESLQGFDKYASEVISNAIKLAQDLLNRDDVREAMSKSIVNIQRMGDDIYVILPDSPAYIQGSGRTSRMYLGGITHGLSVLIVDNEAVFNSLSRDLRYRLVDFQFINYEEFNVDALLKTINEERELIRQIMTGNVPQSISQVDPLKSVLVIVESPTKARTIANFFGKPSTRVLGSLIVYEVTSGNLLLNIIATKGHVVELATEQYAQSVSSDVDYVTKFISSVTRNYYSVLKIDGNFIPIYSTIKRCPTCGRSFTDDVSKCPFDGTPLVDSSGVIEMLRDLATEVDLVLVGTDPDSEGEKIAWDVFNMLRPFVQDIRRIEFHEVTKRAILNALANPRGVNGNMVKAQLVRRIEDRWIGFGLSSYLQRAFNDRNMSAGRVQTPVLKWIIERYIEYRRNRVIRLIVRKRISDGKVLEVSFDKVTNGDETARVRHDLRDVAKDKKGLRIIITKLSESEEEVNPPPPFTTDSMLTEATARLRAGTEEVMRLAQELFEMGLITYHRTDSTRVSAVGISVAKEYLTNRFGEGVFTAREWGMGEEGAHECIRPTRPIDSEELRSLIDSGVLKLKLTNRHIALYDLIFRRFMASQMQSGLVKKVKVEVKLMRNGDMLSSRVDEFVTSVIRNGFLAIYPTIRVTQFPESSMELPVTEEDEVIVKTVHTTYPYREGDIVAEMKRRRIGRPSTYAKIIETLKRRGYVKALGSTKVLIPTKRGVAAYICLSNDKDVAKLYLSTRRNKVQENTEFESLLKQCNVNFKCLISEDRTRMVEEHMDNIENGDEDYLTVLHELFNEAVKYGIMPQN
(775) Reverse gyrase [Desulfurococcus mucosus DSM 2162]
6
MLRSVDPLYKGFCPVCGGDVSASELELYGSCKKCSRSSLTPVLRDIVAGDLDDFSGFFSKATNGLSIWGAQRIWSKRLVSGENTVLIAPTGMGKTTLLIVYSLYAARRGKRVVYIAPTRVLLTQVYRRILDAASRIGLADSMILMYDSSAGKKKREEALARIKQGDYRILVVTNSFLSRKTDLLLPVKPDVVIADDVDSIVRSEKNIVRLLRILGYTDEVVELAKKRISLMWRLMVNRAFNSEEKYAEAVKEYIEVDSELEKKLAETPRSQFIVASATGRMKGLMSRVLKELLHVDISGVTIYGRDVTDSYLLIKQGDSGRGVAELIERLGPGGLIYVAPRHPFKKELEEILGNVLKTLSSKGYRIGEATPGNVMKLVKGDLDLLVGSASYYGSSVRGIDAPEAIRYVVFIGSPVFAVKLEALLANPNMMIRALLEIANLAGDPGARGKAADLRRLVYTLSPGELRLVKLALSGKIPEETLSSSERLSSRYPEIKNYYAETLAKVKSILDERHVVEMGSITLVSVDGDYLALIPDVMTYIQASGRTSRLYGLRMTHGLSIVVEYEPLANTVRGLEARLKAINRELGFTDLRGVNLEHELELIASTRRGGGASNGLKYRSILVVVESPTKAKTIARFFGKPVARRLGDVSVYEIPVKLGDEIVHLNIMPTRGHIFDLTTDNEGYYGVLINEGGVSPVYESIKRCRLCGTQFTSGETCPRCGSRVFTDSKTVVAALRKIAGEVDEVYIATDPDIEGEKIAYDVYLAVKYYNEKIWRIELHEITVQEFLKALGSKRGINTLLVEGEVYRRVLDRLIGFKLSQELQSMHGLRFLGAGRVQTPVLGLVIERYRSFLRNRCKRVSFKLGAPLNTVFTILVDKGSELPSKLKDARVLKLVRTRREEVVVSPKPPYTTDELLADAARLGLPAGTAMMIAQQLFEAGLITYHRTDSHYVSNTGISVAVKYMEEKGFSRVARPSHWGSQGTHEAIRPVHPYDVDDLLKAIAEGLVNVVIPLTGLHLRLYDMIFKRFISSQMKPFKSVKSTFAVYYDGLKLGEVELLTRIVEDGFNLFEKVKVHSELDDVESLDVSVEDVVIADSSRIPLYTEGELVSLMKQLGLGRPSTYSKIIENVRRHGYVIASKKRLKLIPTKRGMEVYEYLVSRYPDLVSVETTRRLEESIDRIGKGEVDARTLLTEVCSRLNIWGKPVEGATSISS
(925) DNA topoisomerase [Desulfurococcus mucosus DSM 2162]
3
MVSGVEPWMSRGVRIWDLKGRVLVIAEKPKAARKIAEALSPGYVTRRIGSIPVYEINAYGSMILVASSVGHLYELNTGVKGYPVYSYEWVPSHLVNPGKRHAREYLEVLKKLCRGVDYYVNACDYDIEGSVIGYLIIKFNGDEEKALRAKFSSLTREELRQAFNNLAKLDYEMIEAGLCRHELDWLWGINVSRALMKAVEDATGRRIVLSAGRVQTPTLKYVVEKTVERNLFIPLPQYRVTVTAERNGEEVVLEYAGNPVEKHGEARSIVERVRRQGYLIVEEVEGKTYVLKPPPPFNLGDLQEEAARIYGFSPAKTQAIAEQLYLDALISYPRTNSQKLPPTLNYRGILDNLASIGKYSGLVASLLSETRGVLKPVEGEKEDPAHPAIYPTGMKPGGLTDEQWAVYDLIVRRFLAVFAQPARLTHYTVKAVTPSRDAVFKASWQRVEEQGWMKYYGFHTYKSSRAPGLVKGDKLGVVKVSMRESYTKPPKRLSKIDVLRWMESVEIGTEATRAQIIEKLFERKYLFLESKGIGVSDLGFGVVEVVERFFPDLLSIELTRRFEKEMDAIRRGLRSRGQVLEEAKRILTAMLGEFDENRVEAGRQLAVRLGVAEPSRGKCRISSCKREAVEEGLCRHHASAARLIHEYYVEWSRRKEIGFDEYVEKLRKSRNTGKWIKEVIEAGVVKAPRFP
(1012) Reverse gyrase [Desulfurococcus mucosus DSM 2162]
6
MPDLPGSPSLPDGFKTHGVYRHACPNCGGPISDYRLIFKAPCEKCLRDEEFRGIVELAGKRGGIDRFQLLRLYAESSREGALRELVKREEMLRDFEAFFEKATGFKMWSAQKTWARRVLKGLSFSIIAPTGMGKTVFSLVTALYITQRARREGDPRGWRSYLVFPTTPLLLQAERKLRAFAENLGVSICSNDNWDNGDCIRILCIHGHLGKRDRETAMNRLKEGSFDILLTTSAFIHRNYELLKGKGFRLIVMDDVDAVLKSGRAVRRLLGIIGVEEEHIEKALTLVKARSRLVAASGEERARLEEEIRGLENEVSSVRSRINTMLLVNSATGRPRGMYPKLFKVFMGFEAGSKPEAIRNIVDSYVEPQGGIEEELVKLVLTLRDGVLVFVPVDKGVEYAERIVELLREKGLRAEAFHSKTSIELLDAFAKGDVNVLVGVATYYGVMVRGIDLPERVKYVVFAGVPRHRFSSMLEALSPTDILRVLAVLRDIAEGEKRDLIERLLGRISSRLRRMSPGAVLRLREELARKIRGESVEETPLLSTLFEAYKVIAEEFSKEETWQRISGLGDVGILKENDKYYMLIPDVATYIQASGRASRLYPGGITKGLSIVVVDDKRLLNGLVRRMRWIFEDFTMTPLSQVNLEELMKQIEEERRRVSEVIKGGTAAGTWVEPVKTALMVVESPNKARTIAGFFGKPSVRIVGNILQVYEVTIGSYVLSITASAGHVYDLVTDKSLPEAEGAEALYGVLRVDGRFIPVYTDIKKCSNGHQFTEELGGNTVECPRCKMDNKQSHVIRKLDVIKALRELAEEVDVVFIGTDPDAEGEKIAWDLRVLLEPYANEVRRIEFHEVTRKAILNALREPRDFDIRLVESQIVRRIDDRWLGFSLSEKVQKYAWMDYCLRYLFHKRGLVEKSTCCRPNGNMSAGRVQTPVLGYIIEETDARSRPERYVYRMKIYIERIGDLVEVSIPYIDAKNAGIVDTVKKRPHPVEVEVVSEEEVQLNPPPPFTTDSLLEEASRTLGLPATRTMEIAQDLFETGLITYHRTDSTRVSDTGVKIARQYLEDKYGEKAPHYFKPRTWGEGGAHEAIRPTRPIDSDRLVELVKEGVLSLPLRLTRDHVRLYDLVFRRFIASQMEAAKLRKLVLRVYIGDRSYETEIYTEAVWKGYLEVYENVRLLGRELGLKPGERVEAEIHDGNRVTPPRLRSHDVIRWMKEQGIGRPSTYAKIVQTLIDRGYVRVTGKVKALIPTERGRSVFNFLGKYYGNVVSVDTTRRLEELMEDISKNTVEYQSALEGIYREVTTAVIGNHRVNELLEKMYREKCSEEK
(1704) DNA topoisomerase [Acidianus hospitalis W1]
3
MFNLTGPSGFPVFEVEWKPLWEIDKKSYYTRKYLILLQRLCKYAKEYINACDYDIEGSVIGYMIIKNFGDLKKAKRMKFSSLTKEELIKSFNNLQPLDYNMVNAGIARHIVDWLWGINVSRALMNAVKDTSKKSVILSAGRVQSPTLIEVVKRHLDRETFVPLPYFKIELKIRLGNIINTVYLDQEFHNIDDVESLITRLKKDKLIVDKNILNKDKIIRPPPFNLGDLQLEAGRLFGLSPYRTERVGEELYLDGVISYPRTNSQKIPPTININEIVTGLSQRFGKLVDELNLMTKGKFIVRQGNKDDPAHPAIYPTGVIPKKLGKQESEVYELIVRRFLASISRDAEVTRQRIILEFEKEKLKLQLDFQKITYEGWLKIYPYHRFENEELVNVNEGSEVEIISIKPKLLLAKPSTRFTRVSLLKWMEDVKIGTEATRGKIIETLFQRKYVVTKRSYIYPTKLGIIVSEVLEKYFNELTDVKMTADMEDKLDEIIYGKKNKDEVINEVKDKISKYFEKYNEEKKIIGLELAKGLNLVAYNKCKLCDFEAMKDGLCKYHLIAKEKLDEAIKIWEDRTGYDIKMILKYIKGSKSTGKLISDLLSI
(18) Reverse gyrase [Acidianus hospitalis W1]
6
MVTSVFLKACPNCGGPLEDYRALAGLPCSKCLPGDISPFKNLSIDEKIRLIYNILVHENKLKGYWNLYYYHQLSQEIIDYFKKITGKEPWSLQKLWLRRLVEGSSFSMSAPTGMGKTTTIIVYSTYLQNSNKNVLYIVPTKSLMQQICEKMEKIGDKTSCGKVGSGISIVTVNYINRNFEEIKEYRPDFVAVDDADAIVKSGKTVDRLVTLMGIPQEVYEDAIKLVKLKRLLAIEEKRDEIETKIAEIESRISKYYGTASQLVVASATLRPKGIKQKALKYITGFDVSTAQIYARNIIDAFTSSSVVDIVNKLGSGGLILVSKEYGKDKIKEVNESLKELGFKTAIALSGRKFLEKFSSGEIDIIIGSASYYGVAVRGIDEPKRLKYVIFYGVPKSRVRLSQAIYNPYTLLKISKLFNVNIDDNLILSLSPSEAQLIKLAFLKSQKLTGKLGEIQKILEGKIDEVKSALKAVSNEVISDTFLIRKIGKEFYIEYPDAITYLQGSGRSSRLLNGGLTLGLAITIIDDFKLYEMLKRKLQYMIYNFNPTNFDSLDIGKVKNEIERSRNDKNEELHISTGLMIVESPTKARTIAKMFGAPARRNIAGVPIYETVIVDGNNVHILDIVATKGHVADLTTENIGYYGVEIRNEDKYPYYSPLYRCMNCKRVFSQEIDKCPYCGSTLISSSMSTINAIRKIAMEVEKVYIATDPDVEGEKIAFDVAANISAYNPNIYRVKYHEVTKKGILEALANPMNIDLNLVKSQIVRRIEDRWVGFELSKLLQIKFSNRNFGAGRVQTPVLGWITKRTEEYRKNMCYVASIKLGNYTHKVFLDNKNVKIDKVIVKKMEDKDDIILPLPPYTTDSLLIDAYNLYKLPAERVMKIAQELFESGLITYHRTDSIHVSNKGIEIAKEYLDKKGLIKSFIPRSWGNEGTHEAIRPTRPIDAEELKKEIEDNPQAYFIKFTWAHFAIYDMIFKRFLASQMKEAIGKYTKYQIKVLDNVSEITVLTSIKGGFSDVLKPRIYEIPEGEIQVNPIITKGSKVRLYTYAEVIKEMKDKNIGRPSTYAKIIQTLMRHGYIVESKKKYALIATKKGINVYNYLNSKFSSLVSESTTAELLEKMDMIAGGKLNADNVLTEILGQIKSLVTSLNSEQQI
(1812) Reverse gyrase [Acidianus hospitalis W1]
6
MSEELPNLVYMNSCPNCGGEITANRLYKGSACEKCVKEDIQFNSVYDLALYLLKNKNLVNLRSSYEILKELKEVERLFKRVLGSPPLGPQRSWIVRALRGESFAIIAPPGLGKTTFGILMSLYFAEKQRKTLMIFPTKTLVNQVVQRIQEMSKSLEEVPKLAYYYSGITQSQKGELNKILESGDFDIFISTSRYIINNVDYISTKDYKYLFVDDVDSVLKSSKSASAVLKLVGFTEDDIQNVRELLRKSKNSEEVYDEIRKIREKKTGDKIAIFSSATITKGNPVFSALMGFRPGSAVIYLRNVIDSYVQLPSATDEEIIDIVNKIVNKLGSGGLIFVPIDKGVSFANEIASNISGLKAEAISSTSITKLDKFEKGEIDVLVGVATHYGILVRGIDIPWRIRYAIFAGIPRFRFKIGETMHPLAMLKMLTLISLVSKDEEVTKILRIVRNKLRRISPAALVMLANSVKSGKIEDKYIQEAYDLTNKYLRNEEILEKIAEIGEISINNRYISSPDYLTYIQASGRTSRIFGGELTTGLSVLLVDNPRLFELLNRRLSIVLDEVSWNPFDIDNNKIGNNNLHEILKRIDSEREKIRKIKKEGLLTSASVKNIKTVLFIVESPNKAKTISNFFSKPSIRVFNGAIIYETVIGDKVLMVTASGGHVYDLTTKNIGIHGIEVRKNSNLEFIPYYNTIKRCNNGHQFTEYAEGNKCPTCGSTIIKDKIDVINSFRQLALEADEILIGTDPDVEGEKISWDLYLALRPYNPNIKRAEFHEVTRRAIVEAINNSRQFSIPLLQSQVVRRVEDRWIGFSLSTKLQTVFWPQYCSEVLKRTDCGENKNLSAGRVQTPVLGWVINRYNKYNETKRTVFVVKFLNSLSVLVPKQADLDKNDVKVIVYNISKSSETFGPMPPYTTDEMLSDASNLYGISAPEAMRVAQDLFEMGLITYHRTDSTRISNTGIAVAENYLKEILEDKYKEIFKPRTWGEGGAHEAIRPTRPLDENQLRALIEEGELELPKRLTLNHYRIYGLIFSRFISSQIVPLNVDKLKFNIKVLSNGKELKVENPEMDLITNVSLPGGIEVSKLSLYYPRSYFASRDSSYSDTIKKLEECIKSGQCEFTGSIASSFVKSDYQLYTQGELITEMKNKKIGRPSTYATIIATLLKRGYMLESKKVKRLVPSKLGINVYNFLTSKYSKFVSEERTRQLLELMDLIEDGKEDYRQVLKQLYDEIQSIG
(510) Reverse gyrase [Pyrobaculum sp. 1860]
6
MDIPLVVYLHSCPNCGGPITSDRLALGLPCRECLPEGSKAASIREVVAALRRRRALRGLAWVDAYLRSYEEFSAFFKEVVGFEMWGAQRLWARRLVRGKSFAIMAPTGSGKTTFILVATLYLAGGGRRALLIFPTSALAHQAHKKLTAFAERAGRRVKALAYHSLLTEQERREVLEALERGDFDVLVTTSAFLPRRFDLLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDSVLNAALEVINLAKQMRKAEVAGDLKEVERLDQQIASLRARLREEVGKLKLGVFVASGALAKARRTVRLLLFREILGFDVGGRAEGLRNVVDLYAEAGGDLAGQVVELLKRLGPGGIVYVQDRELGETIAERAREAGIAVETFFRPRRGVLERFERGELAALVGLASSRSALVRGIDLPHVIRYVVFAGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLSGDLRYRADRLIGQLKRLAPYTLSVQEALRKAAEGGELSSFDRHSVEVVKSAVEFVGDLLRREEIRRTVETSTEVKLAYINGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVLVDDAKVFHALRRELKLRFDEAEFRRLDEVDLGKVLEEVDRDRRAIRDIIEGRAAPAATGVELMKTILMIVESPTKARTIANFFGRPSLIIADGVPIYEVSTGDAVLMVTASLGHIYELPTSLARIEQRQREVLAKWFGDFKHDGYNGEDYAVIVTKSGFVPVYNKIWRCRGGVYVDDVDIPQNCKPLDVLESIRNIAVEVDTVLIGTDPDSEGEKIAFDLYMGLRPYVSDIRRIEFHEVTRRAILNALASPRGVSFPLVKGQIVRRVEDRWIGFGLSKVLQERFGNPNLSAGRVQTPVLGWVVKTYEESLRNRMYNVDLQLDDVDLRLQIPRDVLDVLRKKKRLAVKLLGRESRVVNPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGVAIAREYIVKKFGEGAFKPRTWGEEGEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQPTRSHYQLYDLVFRRFVASQMEPSVARVAKYELEVDGHVLTLERVVDIERQGFQVVYQVTPVEPELPTGTIDVVVKRYRVIRRVLSQADVLALMRQRGIGRPSTYARILQVLAKRYYVYVTGRSKIMVPTKRGIEVYHYLENTFSKLVDEERTRLIEQLMDAIEAGKAVYEEVLQELYNEFKINVLPSLSKT
(215) DNA topoisomerase (TopA) [Pyrobaculum sp. 1860]
3
MILIVAEKRSVAQAIAKYLGRSYRVQRIHGVPVYSFSYGGREAAALGLSGHIMDFDFAARQNVWTWLPPEELFNATPLLVVRREALDYVKALRALAAKADEVYLALDADVEGEAIAYEAALVVRSVNKRAPIRRVLFNAVTPREITAAFQRPTKLDLKKVEKVFTRMQIDLTLGAAFTRFLTLAVREHLERGRFLSYGPCQTPVLGMVVTRELQRRNFKPEKYYILKALVEVEGHRIEMSSDVRYKSREEGERAAASVKHGVVKTALYKPHEVEPPEPLETVELERRASRWLGINAKKTLDIAEELYRAGYISYPRTETTIYPQTLDLREILRDLAETEHGPYAEELLRRSFKPTRGDSDDGAHPPIYPTKGATKAEIMKIFGKAGAQAWAIYDFVVRHFLATLSPPALVEKQKIAAAFGGVEMYAEGQRVISEGYWRIYPWERQRDKPLPRVSPGAPARAIKVEVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIHTNVKRGYMKLAKGRCVPTDLGIALATALFQHAPELIEPTVRAKIEAALNSIVRNSTPPPKLIAEVKAEFRTYYENLKARREEIKKALLNALNTHRQ
(539) DNA topoisomerase [Sulfolobus solfataricus P2]
3
MNLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVSYWIIKDHNSSKYVIVPAAGHLFGLKGESGFPVYDADWKPLWEIDKNSYYTKRYYQLISSLSKYALGFINACDYDIEGSVIGYLIIKNLGDIKKAKRMKFSALTKSDILSAFRNISALDYDMINAGIARHKIDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVNSEIERNLFIPLPKFTVSIIVKIKDYSLNIKVNKEFEKITEAKEFLNKLINKTVKVVEVENRVRLLERPSPFNLTDLQIEAGRIYGISPYNVERIAEDLYLDGLISYPRTNSQKIPSTISIYNIIKGLENSSYRKLVDLVRKITGGKYVVKQGIKDDPAHPAIHPTGEAPKNLPNSKFKIYDLIARRFLGSVSADAKLSNTIYTLKVSDFPLEFTVSYTKILERNWLDIYHFHNVKEDKPIFLSKGDEGKIVDGKVNISLSKPTSRYTKVSLLKWMESSNLGTEATRGRIIEILVKRKYLTNNGRYIIPTKLGFYIAEILNKFFPDIVDVRMTADMESKLEMIKTGKVLESKVIKENIEKLNKFIEEYKVNKDKVGESLAKALGLIKIVKCKYCDLEQYKDGLCKYHYEAKVRLLDAVEIWKERTKYDHKKILKRISSSKSTGKYVKDIVTYMLSSE
(7) Reverse gyrase 2 [Sulfolobus solfataricus P2]
6
MINVMYKNSCPNCGGDISGDRLLNGLPCEACLPYINGIDDVDHISKVKTLYNILLNNDKIKNYWNLYYNITTFETVFKYFRDKTGYEPWSLQKLWLRRLASNQSFTMSAPTGLGKTTTLMTYSVFIGQDVVYIVPTKSLMEQVCKRLEKLGAQVSCGKIDQKKVSVITISYLNKNADSIVSLKPNFVVIDDADAVIKSGKTTDRLVSLLGIPKDVYESAIQLIRLRNKYYFSNEYTEEVKEKIRELELKIAEFKDKISQLVIASATIRPKGIKQKALRLLTGFEPSSIQLYARNIIDAYTENLDLSIVKELGSGGLILVSKEYGRSKLNEIKKYVEDLGFNAKLAISGRKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIRAKLFDALSNPFTLLRVGKLIGIDFSKLQNKILILNPSEVQLLKFSIIKGESINYHKLEQLRQELLYYMSLVKDKLKEKVEDTLISDSFVITKQNGNYYIVYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDRHIFEILEKKMQKLFPNTTFTSLSNTNLSEIKIKLEDSRKEEGNRVHFNISTGLLIVESPTKAKTIAKMFSRPSVRIRNKVPVYETIIVDGNQIYVLDIVASKGHIVDLTLEDIGYYGIKVEDDGTIKPYYDLIKKCLDCNKIFSSASDKCPYCGSANLQSAQTTINLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVYRVVYHEITKKAILEALRNPKKINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVNKTIKYKSAMGHVVYIDIAGYSIKKYFSEKRKVEEYINNLQVARIEKISEEKILLSPLPPFTTDTLLIEANMKYKLPANLVMKIAQDLFEAGLITYHRTDSTHISSVGIEIAKEYLQKQALIKEFVPRSWESSEEGAHEAIRPTRAIDVNELIQEIEENPYKYSIRFSKLHLLIYDLIFKRFIASQMSHAVGTKSRYLIKLGKDDNVDVELLSNAEGGFIKVYPVKVYNLPVGEIQPKVNITKGSSEQLLSYSDVISLMKSKGIGRPSTYAKTIENLMKHGYIVSSKRKSYLIATNRGISVYQFLSSKFYDLVSESTTSRLMTKLDDIALSKLNASTVLLEIFSEISTLVNPLKSEQNV
(334) Reverse gyrase [Sulfolobus acidocaldarius N8]
6
MLKVNYLFGCPNCNGSISVDRLHAGIPCETCLPGAVEKLDIRTIYDLLVKYSTLKGYSELYMDLEMYDDILRLFKKIVGGEPWSLQRYWLNKLVRGESFSLSAPTGVGKTTTLIVYSVYSHTTSLFVVPTKSLRDQICEKLKKIGHLVSCNKPEEDKVNVVTFHSINKNIDEFVRIKPKLLMVDDADMILKSGKTTERIAKVLQIPQEVFDDTIKMLRLKRMLRFKEDEDLINQVRELESKILGYKSSVQFIVSSATLKPKGYKQMALRFLVGFEPSTIQIYNRNVIDSFTYSNNVNELVKEIGDVGGLILVSKDYGKKYVDQITDNLNAEGYRAMKAISGRKFLEKFSNGDVDFLVGSASYYGVAVRGIDEPKRLKYVIFYGVPKTKLPLEDSLNNPLTALKIGELLKLDVTEYRKRLIYLSPAELQAVKIALRNKVSLNGKLGDLVEDLTKLKDIILDTIKANKIDKLVSDSFVIKKDTNKHYIFFPDIITYIQGSGRSSRIMNGGLTLGLSVVLVDDLELFDILNKKLRRIAEVTFMNFDELKLDEVREKLNKSRSDGSGGRSMNFKTALLVVESPTKARTISKIFGRGVRREIYGIPVYETIIIDDHSNTIIYTNIIASKGHLTDLTTEELGYYGVEINDKDIVVNYSPLYRCMSCGKTITKKVSTCPYCGSSMINSSEKIVNAIRLISTEVDEVYIATDPDQEGEKIAYDIYSLISPYNQNIFRISYNEITKTAVLNAIKSKAKINESLVKAQIARRIEDRWIGFELSSVLRSALNDNNNGTGRVQGPVLKWVVGKTSEYKANIGYVVDINIGDYVVRKFFKTKKDAETFISQLNVKVTKIAERTSTIDPLPPFTTDSLLIDAYSKFRINSSLAMKVAQELFEAGLITYHRTDSIHISPYGISIAREYLEKIGSNDFVGRSWGNEGAHEAIRPTRSMDVEELRKEIEENPFQFGIKFTWAHYRLYDLIFRRFIGSQMSSATATYTTYEININGELYTVELPTKVHGGFSSIYGIRVYNLDESHLTTRIRKGSLVSLLTYADVIRLMKDTNIGRPSTYVRTVQSLIRHGYVVESKKRSFLIATNKGQKVYEILNKYFSDMVSESRTSHLITKIDKINRNELSAEDVIMDLLNEIKNIKLVNPLQSEQYV
(746) Reverse gyrase [Staphylothermus marinus F1]
6
MEKILDPIYKNLCPTCRGDVFANSLWDFGVCGKCSDEPGNSINAVTLYHAFKEDLEDFTHFFGKATGDLNPWGAQLTWAKRLLNGENTVIVAPTGMGKTTLLIVYSVYVAKNYNKKVLFLAPTRALAKQIYTRIIEAVKNVCGTCINVLFYDSGLSKKRREEVLLKIKNNEYDILVLTNHFLIRHYDLLDPNHIGLIVIDDVDSLMRSSKNILRLMKLLGFREELIEKAKKRNSIIWKLMLSKSLNKEEDYRKYIEELIEIEAEIDELLRNSSRKQVVIASATGRMKGIYAKVMRDLLRIDVSGITIYGRNITDTYLLISDHVRDTDKILGFIETLGPGALIFISPRHPLKKNLIELVGLLRRKLEEKGYRVAEANPSTIKKFVRGEYDFLIGSSSYYGVSVRGIDAPETIKYVLFIGTPLFTVELGSFLASPNMLIRVSLMLSEVLGDQRFRGVASTIRKLVFPLNNGEIKLLSMLLKNKITINDLGKDSRIVKVYEQILDFYNDIRKSLEELLSKKKVVDMNTITFYHDNNKFYALIPDVMTYIQASGRCSRLYLGKMTHGLSLVVEYDFLSNLVNGLSLKMNMFSRGFGFKDINDIDLYEEKKLLEKTRKELKGLVLTYRNILVIVESPTKAKTIARFFGKPVRRKIGSISVYEIPFVKDSEVIHLNIVATRGHLFDLTTDPSIPNHGVLIENNRISPVYTSIKRCRVCGYQFTYGDRCPRCGSTSFTDSYEVVNVLRKLAQEADEVYIATDPDIEGEKIAYDVYLTIKGFVDRVWRIELHEITLNEFLNALENKRNINLKLVEAEIYRRVLDRVIGFSLSQELWRKYSKNWLGAGRVQTPVLGWIIDHYNKYVSNKCRKIIYITEREGLKFSICIDLKDRDLYEKMRSVEYVTLVLKNSRIETFNPPPPYTTDELLYDASRIGIPSTLTMKIAQELFESGLITYHRTSYHYVSSAGISVASKYLENKNLSKHFHPSHWGNKGAHEAIRPVHPLDREDLEKAVVEGIITPTIPLTWLHYRIYDLIFKRFISSQMNPYKALISEYDVVINNEIVKTLVLPIEVVEEGFNIVMRPKTYGFLKGHDRIDISIKDIKTMITSTKPLCSEGGLVKLMREHGLGRPSTYSKIISNIVRHGYVIRSKKRGFLIPTKTGIEVYDYLSNSFPELVSIDTTRDMEMRIDLIAKGEMRAADEISRVIDRIRRYKLPLSIREVVAEASA
(926) Reverse gyrase [Staphylothermus marinus F1]
6
MVELKHIHGYYRYSCPNCGGEDSDLRLIHKAPCDKCIEEELFYRIRENIGEKSYKEILETYYRMLLKNNKLKKRFEFLYKFEEKLEKFEKFFSEATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYLSKKQIMIQKNRISRKKIYLVFPTTPLLLQAEKKLRKLAEQEKIPVCQEEDSDQTCLNIISIHGRVPKKKREKLLEEIRSGNFDILLSTNMFMHKNYELLLDKKYELIVMDDVDAILRSGKAIRILFYILGLTDQEINEAIEYLKLRQRLALKLSEEERRELEEKLETLEKRIEKYKRKIDTVVIVSSATGKPRGIYPRLFRILLNFEAGSRAEAIRNIVDTYTYSKESLEQTIIRLAKKLGDGGLIFVPIDKGVEYAETIAELLKKHGINAEAFHAKKAVKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFSTRLESPSPIDVLRIFTILRDVLEGEEKRKAEILIGRISLRLRRLSQGALMKLKEDFMKKLQGEEVEEYPLLSLLMEALSMARELLSKPEIWEKLKQKGDVALVQEDGKSYILIPDVATYIQASGRTSRLYPGGITKGLSIVIVDDQRLLNGLIKRMRWLFEEFDMKRLDEVDLDKLMKEINEERRKVKMILEGRIEVEKTLELTKSALLIVESPNKARTIANFFGKPSIRILENGMPVYDVTTGDYVLSIIASIGHVYDLVVDDGLYNYGVRLVGDKFIPVYTDIKRCNKCGYQFTAETNTCPKCGSRDISRKLDIVETLRELANEVDVVFIGTDPDTEGEKIGWDIKVLLEPYAREIKRVEFHEITRKAILNAIRNPRDFDMKLVEAQIVRRVEDRWLGFALSKKVQKYFWPIYCFKVLHPLLNKYVREGKRITDKMPFCCIENRNLSAGRVQTPVLGYIIRRFKEHNDESKFRYLLTIKINDSRLRVDIDRSVLEIIGITSHRNLIGYRVEVREEDRKEEIINPPPPFTTDTLLEEASIRLGLSTTRTMEIAQELFELGLITYHRTDSTRISDAGINVARQYLEEKLGEKAKEVFKPRTWGVGGAHEAIRPTRPIDADRLAELIREGALILARPLTRLHYMVYKLIFNRFIASQMIPAKIVKQVLKIRMNGYEKKVERVIGIIEKGFLEFYQTVNVEEEVKPGTYPVVDVEVLKPPLARYHDVIKWMKTNGIGRPSTYAKIIQTLIDRKYVNVSKRVKALIPTKRGTMVYEEFLDKYYKDVVSVEVTRELEKKMKEVEEGIRDYQEVLHEIFNELKTKIIDNPVVNKELEQKWSKHCGQIESSK
(636) DNA topoisomerase 1 [Staphylothermus marinus F1]
3
MGDKAKKSIIDYILSYSEKQKKKPVKTKEKTSSKKAIEKTEIQITHNIWDLIGKIVVIAEKPKAANKIALALSRNPIRKSMYGIPYYLIKNRHSSIIVASAAGHLYGLHTDQYGYPVFKYEWKPLYQIDPKAKHTEKFIMVLSKLCSNADYYVNACDYDIEGSVIGYLIIYFHGDLEKSLRAKFSSLTIEELRESFRKLTSLDWEMIEAGLCRHELDWIWGINISRALMSSVKIASGKRVILSAGRVQTPTLRYVVEKDIERRLFIPLPQYSLSINIFKNNYEIHVEYKGKSVETKKNAKEIIDEIKRTGYLIVKKYEEKIYTLNPPPAFNLGDLQEEAARIYGFSPYKTQSIAEKLYLDALISYPRTNSQKLPPTLNYKAIMNKLSRINNYKELVSNLLVETKGVLKPVQGSKDDPAHPAIYPTGVKPKDLGKDEWKIYDLIVRRFLAAFASKARISHRIVYLEYPKDPSMVFQASGQKILDLGWLRYYPFSKPEERFLPKFQYGEKVKIVKASIRKTYTKPPEKINKIKILRWMENVGIGTEATRARIIEILFSRYYLRSVGGRVEATDLGLGIIEVLMEYFPEITSVSLTRHFEEEMEKIRLGVKRREEVVKDAKNTLIKLIVSFDKKKYQIGKTLSYRLGYITPINKCILCNREAYKNNLCKYHYRALNTVIKTYDEWKRREGVDWNKYLSSIKKLKSTGKWIVEVIQNFEKIKYSPSE
(608) Reverse gyrase [Sulfolobus islandicus Y.N.15.51]
6
MTSIDKVPPSIYTRSCPNCGGNVSSQRLFNGSACESCLKEDKEFNNLSDLINILSENNTLKNLNQLYNILEEYKEVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYNATRNRKSIIIFPTRTLISQTVDKLAKFSESYSYSPRILYNKQSSTQTENVLEQLKSGDFDIFVSTSRYVIQNLSELSNVKFDFIFVDDVDVALKSGKSAKAILRLVGFTDEDIQTTMKLLRENIGDEEKFGKIQEIRENKLKDKIVIFSSATISRGNPTLSSLMGFRPGSSVIYLRNIYDSYIDLTQTCKERDVDECTLGTVIRVLKRLNDGTLIFVPIDKGVQYAEYLASNLRDHGINAESVASSSISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIGEYMHPLALTRLLNLVYLVKNDDKIRGLLSYIRKRLRRISPAALAMLAKDIREGKIDDERLKEAYSLVNEYLKDTEFLKKISAVGDLVIEGDYILMPDYLTYIQASGRTSRLYGANLTTGLSVLLIDNLRLFELLNKKLNLILDEVKWYPLDIDADRLGQVSLSDIVTKITEERENLSKMKKEGRVESSAINVKTTLFIVESPNKAKTISNFFSRPSTRSYGKLRVYETVLGDRILIVAASGGHIYDLITEDDNERYDGNYVYGVLVKDNKFVPIYSTIKKCEKGHQIVKDLSENKCPICGSKIVADKTEVVDILRKLALEADEVLIGTDPDTEGEKISWDIYLAIRPFNSNIKRAEFHEVTRRAILNAIKNPREFNDNLVKSQIVRRIEDRWIGFKLSRKLQTEFWEQHCKSISKENTECKENRNLSAGRVQTPVLDWIVNRYQKYNENKKKYLIIESQDKSVFPFSILASKKNGLSKKTQLFIQIVDINTKEEDFGPLPPYTTDTLLTDAANLLRIPASETMRIAQDLFELGLITYHRTDSTRISNVGISVAESYLKSKQVDISKVFRPRSWGEGGAHEAIRPTKPLDETMLKASIEQGDLELSKQLTFNHFRVYNLIFRRFITSQLPPLIVTKQIVKIKAYTDDNTELDLDEGKKEFVIGYRLKEGDEFRQVLQEAIYTTFKPYQPIDEKMKGKELIGKVTSTLNKSDVQLYTEGELISEMKSKQIGRPSTYAVIISTLKKRRYIIESKNLKKIIPTKLGMAVKEYLMEKYKQVVSEKRTVKLLEKMNEVEEGKVDYLVLLKELYNEIQTIS
(973) DNA topoisomerase [Sulfolobus islandicus Y.N.15.51]
3
MNLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVNYWIIKDHDNNKYVIVPAAGHLFGLQGKSGFPVYDVDWKPLWEIDKNSYYTKRYYQLISSLSKYALGFINACDYDIEGSVIGYLIIKYLGDTKKAKRMKFSALTKSDILLAFRNVSTLDYDMINAGVARHKIDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVSSEIERNLFIPLPKFTVSVIVKIKDYSLNIKINKEFEKLAEANEFLNRLINKTVKVTQVENKIRILERPPPFNLTDLQVEAGRIYGISPYNVERIAEDLYLDGLISYPRTNSQKIPSTINIYNIIKGLENSSYRKLVNLVRKITGGKYIVRQGVKDDPAHPAIHPTGESPKNLPNNKFKIYDLIARRFLASVSADAKLSNTIYTLKVADFPLEFSVSYTKIPERNWLDIYHFHNVREDNPILLSKGDEGIISDGKVNISLSKPTSRYTKVSLLKWMESSDLGTEATRGRIIEILVKRRYLTSNGRYIVPTKLGFYIAELLNKFFPDIVDVRMTADMENKLEMIKTGKILESEVIKENIEKLNKFIEEYKANKDRVGESLAKALGLIKIVKCKFCDLEQYKDGLCKYHYEAKTKLLDAVRIWEERTKYDHKKILKRISSSKSTGKYVKDIVTYMLNMNDESHANLKR
(1701) Reverse gyrase [Sulfolobus islandicus Y.N.15.51]
6
MINVMYKNSCPNCGGDISADRLLNGLPCETCLPYINGIDGVDIISKVKALYNILLNNDKIKNYWNLYYNITTFEIVFKYFKDKTGYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFIGQDVVYIVPTKSLMEQVCKRLEKLGAQVSCGKVDQRKVSVITISYLNKNANSITSYKPNFVAIDDADAVIKSGKTTGRLVSLLGIPNDVYESAIQLIRLRNKYYFSNEFTEEIKEKIRELELKIAEFKDKISQLVIASATIRPKGIKQKALRLLTGFEPSSIQLYARNIIDTYTDNLDLSIVKELGSGGLILVSKEYGRSRLNEIKKYVEDLGFNAKLAISGRKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFDALSNPFTLLRVGKMIGVNFSELQNKILVLSPSETQLLKFSIIKGETINYQKLDQLRQELLYYISLVKDKLKEIGEETLISDNFVITKQNTNYYIIYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDKHIFEILKKKMQKLFPNTNFTSLSNINLSEIKTKLEESRKEEGNRVHFNISTGLLIVESPTKAKTIAKMFSRPSVRVINKVPVYETIIVDGNQIYVLDVVASKGHIVDLTLEDIGYYGIKVEDSGIIKPYYDLIKKCLDCNKTFSITSDKCPYCGSTNVQTAQTTINLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVYRITYHEITKKAILEALRNPMKINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVDKTMKYKSSMGYVVYIDIAGYSIKMYFSERKKMEEYINNLQVVKIEKISEEKILLSPLPPFTTDTLLIEANMKYKLSANLVMKIAQDLFEAGLITYHRTDSTHISSVGIEIAKEYLQKQGLIKDFVPKSWESSEEGAHEAIRPTRAMDVNELIQEIEENPYKYSIRFSKLHFLIYDLIFRRFMASQMSHAVGTKSRYLIKLNKDDNINTELLSNAEGGFIKVYPVKVYNLPLGEVKPKVNTGKGSSEQLLSYSDVISLMKSKGIGRPSTYAKTIENLVRHGYIVSSKRKSYLIATNRGISAYQFLSSKFYDLVSEGTTAKLMSKLDDIALSKLSASTVLLEIFSEISTLVNPLKSEQNV
Family distribution
Taxonomy tree
Thermoprotei