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Taxon : Bacteria
Informations
Name
Bacteria
Rank
superkingdom
# topoisomerases
1579
Lineage and sub-taxa
Lineage
Bacteria
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(170) DNA topoisomerase 1 [Sinorhizobium fredii NGR234]
1
MNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLILATDPDREGEAISWHVLDLLKKKKVIGDKPVKRVVFNAITKKAVLDAMADPRDIDISLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLQPKAVGNGEEANRLKALLDGASYVVESVEAKPVKRNPGPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDVGGETVGLITYMRTDGVQMAPEAIDAARRAIGSQFGTRYLPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDEVRRFLDGDMLKLYDLIWKRGIASQMASAEIERTTAEIAADNGGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDESGRLPEINARENLAKQKINATQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATISTLVDRDYVEIDKRKLMPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLREFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRTCQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSNGDAEAAVSNEPQSLGKDPHTGEEITLRSGRFGPYVQRGDGKDAKRASLPKGWTPATIDHEKALALLSLPRDIGKHPETGKMISTGIGRYGPFVLHDGTYANLESVEDVFSIGLNRAVSALADKQSKGAGGGRTAAAALKELGEHPDGGVMTVRDGRFGPYVNWGKVNATLPKGKDPQSVTVEEALALIAERAAKGGVSKGKAGNGKAARGRSSTAATKSTAAKAEKPKAAAKAKSKTAAKAKKG
(1016) DNA topoisomerase 3 [Shigella flexneri]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIA
(1727) DNA topoisomerase 1 [Shigella flexneri]
9
MGKALVIVESPAKAKTINKYLGCDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(1015) DNA topoisomerase 3 [Shigella flexneri]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIA
(1033) DNA topoisomerase 1 [Shigella flexneri]
9
MGKALVIVESPAKAKTINKYLGCDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVHKDHALTLVELTPVHHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGRATGWSAFYVDGKWVEGKK
(1790) DNA topoisomerase 1 [Synechococcus elongatus PCC 7942]
1
MPKLVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASDIPTELKGEKWSNLGVDVENNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESISWHLLQLLQPRVPTKRMVFHEITQEAIQAALKNCRDVDQRLVHAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTLAGQRLATGNDFDESTGQIIAGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTTRKPAPPFTTSTLQQESNRKLRLSARETMRVAQSLYERGFITYMRTDSVHLSQQAIEAARSCVEQMYGKNYLSPQPRQFTTKSKNAQEAHEAIRPAGNTFRLPQETGLSGAEFALYDLIWKRTIASQMAEARQTMLSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAALEDREILLPALKVGDRPTCQELAAIGHETQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSNTLTPTFTAFAVTALLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFYRGDRGLEEQVKLRESEIDPAAARTVALEGLPAKVRIGRFGAYLEAEADGEPIKANLPKELTPADLDVQRVETLLRQKTEGPDQLGTHPETDEPIYLLTGAYGPYVQLGAATEEKPKPKRASLPKGMSLETISLEQAVGLLSLPRTLGEHPETGRRIQAGLGRFGPYVVCDLGGGEKDYRSLKADDDVLTIDLDRALELLAQPKKSRGRGKEPIREVGLHPDDQAPIQIFEGPYGLYLKHGKVNASLPEDEKPETISLETAVAALAAKAGQAKAKGGRRSTGTPKSGETKARTTKTTKKTTTRRTTSR
(1789) DNA topoisomerase 1 [Synechococcus elongatus PCC 7942]
1
MPKLVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASDIPTELKGEKWSNLGVDVENNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESISWHLLQLLQPRVPTKRMVFHEITQEAIQAALKNCRDVDQRLVHAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTLAGQRLATGNDFDESTGQIIAGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTTRKPAPPFTTSTLQQESNRKLRLSARETMRVAQSLYERGFITYMRTDSVHLSQQAIEAARSCVEQMYGKNYLSPQPRQFTTKSKNAQEAHEAIRPAGNTFRLPQETGLSGAEFALYDLIWKRTIASQMAEARQTMLSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAALEDREILLPALKVGDRPTCQELAAIGHETQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSNTLTPTFTAFAVTALLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFYRGDRGLEEQVKLRESEIDPAAARTVALEGLPAKVRIGRFGAYLEAEADGEPIKANLPKELTPADLDVQRVETLLRQKTEGPDQLGTHPETDEPIYLLTGAYGPYVQLGAATEEKPKPKRASLPKGMSLETISLEQAVGLLSLPRTLGEHPETGRRIQAGLGRFGPYVVCDLGGGEKDYRSLKADDDVLTIDLDRALELLAQPKKSRGRGKEPIREVGLHPDDQAPIQIFEGPYGLYLKHGKVNASLPEDEKPETISLETAVAALAAKAGQAKAKGGRRSTGTPKSGETKARTTKTTKKTTTRRTTSR
(937) Putative DNA topoisomerase [Lactobacillus brevis]
3
MSIVVLTEKSSQIDPYAKALGTPKKKQGSVWVHSALLNADVQFVAASGHLFKLDGPEDYNDAWRDRSNYEQLPMVPQKFKARIKDARARASFNRIKQAITAADEVILATDPDQQGEVIGREILQRIPGGMEKCQRRLLNSSLTAKGALRSFENLVPMAKQEHLGAAGFLQNRLNWLIGMNLSRVGGIQLKKRGYYFPVAAGTVKTPTLALVVANDQEIKHFKEAPYWQIELTDQANQQRFKAQPSRHFSIEDEAKQALAQVTDTLTIKSVDQVEQHRLPPKLFNLTALQGYAAKKWGYSGTEVLETMEHLYKDLAITSYPRTESTVIEDAEFDYLKANFNDYAATLNLKMAMQVPDARPEFVKTTTDGHPALIPTDKVADLSQLTERERRCYGAVVKRTLLMFAGDCVLDKTVVKGTLGTEQIYEATGQQFKDLGWTEFDVVKTENRELPSYQQGQQVKIETSLVEGKTKVPQRITEGMLFSKLFPKYNLGTPATRAGIVSELIEKNHYIEVKGKRRELYPTSEGINMVAFWQGTLLTDLKLAKSWQDIFDKVIQGNMQPDRYQEQMVEALTDIVADYRTKKPDLPIAPKPHTSYEFKPLTPAVKCPKCHRGELGLLVATNAKNNQFYACSQKKCHFSLPNKYSGIALTSELVRQLATKKQTDWLPEVKSSQGKVYRNQVAFILAEKLKLQWTFKQTAKKTERTD
(1078) DNA topoisomerase 1 [Streptococcus gordonii str. Challis]
1
MYKLVTKTSKKSTTKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSTMSIDFENNYEPQYINIRGKGPLINDLRKEAKKAKQVFLASDPDREGEAISWHLAHILNLDEKEKNRVVFNEITKDAVKNAFKEPRQINMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEINAFKPEEYWTIDSTFKKGSRQFQASFYGINGRKMKLTNNDEVKEVLSLLKGDDFKVESVERKERRRNAPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAANYITDRFGAKYSKHGSKIKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMNVKIEQNGVQFTANGSQVKFDGYLAIYNDSDKNKMLPDMEKGDTVKRVNTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVKLVSKRFEPTELGEIVNSLIVEFFPGIVNVKFTAEMEAKLDDVEVGKEQWQKVIDEFYRPFEKEVAKAESEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVTCPQCQKGHVIERKTKRNRIFYGCNRYPDCDFTSWDKPVGRNCPKCDHYLVEKKVRGGGKQVVCSNGDYEEEKVK
(1565) DNA topoisomerase 1 [Clavibacter michiganensis subsp. sepedonicus]
8
MYGVPCRGPRRTSPRIGSDPSGHASRTPGRSSVPMNAYIRSHVPGTKKLVIVESPAKAKTIAQYLGSGYEVQASVGHIRDLIEPKNLPPELKKGTLGKFSVDVENGFEPYYVVSDQKKKTVADLKRALKDADELFLATDEDREGEAIAWHLLQVLKPKVPVKRMVFHEITKEAIERARDSTRDIDTALVDAQETRRILDRLYGYEVSPVLWRKVGPGLSAGRVQSAATRLVVDRERERLAFVTASYWDLTASLSPLEQELPFDARLVRIDGARIATGRDFDDKGALKNDSRPLDASSAEALAEALRDPSVPLKVQSVESKPYTRRPAAPFTTSTLQQEAARKLRFSARQTMSVAQSLYENGYITYMRTDSPSLSQQAINAARKQAAELYGPETVPDKPRLYAGKSKNAQEAHEAVRPAGETFRTPQQLASTLRGNDHKLYDLIWKRTIASQMADAKGSTASVVIAAGPTSAGEVAEFAASGTVITFRGFLAAYEESRDEERHGAAEPREAKLPDLKKGQDLRLVDVDAKGHETSPPPRYTEASLVKTLEELGIGRPSTYAAIISTIVDRGYVTPRGTALVPNWIAFSVVRLLEEFFTELVQYDFTAGMEDDLDRIAEGAAERVDWLKGFYYGNDAHKGLRPTIDNLGEIDAKEINSLRIADDITLRIGKYGPYLEVHEEGAAADATPRRVNLPEDLAPDELTAAKARELIDAPVVTDRVIGINPDNGKQVVAKDGRYGPYVTELDPEPEPEAAPAAAADGVDPATGEVLESASTTTTAAPAKKAPAKKPAAKKAAAVKPRTASIFKSMDLATVDLETALRLLDLPRVVGEDPETATPITAQNGKYGPYLKKGTDSRSLTSEEQIFEIDLPGALEVFAQPKYGARRPSSALKEFDADPVSGKGIKVKDGRFGPYVTDGETNATIPKSESVEDIDFDRAVELLADKRAKGPAKPKAKAKAPAKAKAKAPAKAKAPAKPGAAAKATGTTAAATKAAATRAANKAAAAAATASDAT
(1211) DNA topoisomerase 3 [Saccharophagus degradans 2-40]
10
MRLFIAEKPSLGRAIADVLPKPHSRGDGFIRCGNGDVVSWCIGHLLEQAEPEAYNPVFKQWRLEHLPIIPDQWQLKPKSKTRKQLTALRKLVKEATCIVHAGDPDREGQLLVDQVIDFLGVKGAKRESVQRCLINDLNPAAVKRSLDTLRSNKEFIPLATSALARSRADWLYGINMTRAYTLQGRKVGYEGLLSVGRVQTPILGMVVERDRAIEEFVSKPFYEVLAHLTTLTGEPTAFTAKWLPSEACEPYMDEDGRVLSKKLAQNVIARITGENGVVEKVDKKAKAQAAPLPYNLSSLQIDAAKRFGFAAQKVLDICQNLYEKHKLITYPRSDSRYLPADHWHQANDVLQAISANVAELVQSVSGANSKLKSKAWNDAKVDAHHAIIPTAKKVSFSSITSEEQKVYSLIARQYVCQFYPKWEYSDTVIHLKIAGGQFVSKARLTHKQGWKVLFERKGGEPNPKDDDEFPSLTLPDLHVGQSVACRQGELLEKQTQPPKYFTDASLLAAMTGIARYVTDPDIKKILKDTDGLGTEATRAGIIELLFKRNFLVRKGKQIHSTPAARGLVAALPSSATTPDMTAQWELVLNAISIREAQYTTFMKPLVASLQTLIAESQRNLPIGLKGVAAKPKAFKRRRKVKAKSV
(543) DNA topoisomerase 1 [Saccharophagus degradans 2-40]
9
MEKSLVIVESPAKAKTINKYLGNKFVVKSSVGHIRDLPTSGGAKSTVDPKERAKQAALTRKMSPEEKAIHREKKSREQLINRMGINPEKNWEARYEILPGKEKVVEELKKLAEEADTIYLATDLDREGEAIAWHLQETIGGDPDRYRRVVFNEITKTAIQKAFEKPSMLDLNRVNAQQARRFLDRVVGYMVSPLLWEKIARGLSAGRVQSVAVRLVAEREREIRAFIPEEYWDIAAQLDTPKGERAGFDVKKYQGNVFRPVNEKEAMEAVERLKASAFKVTSREDKPTQSKPTAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSAEAVETCRGFILDTFGEKYLPEAPISYSSKEGAQEAHEAIRPSDVTRRPDSLTDMERDAQRLYTLIWNQFVACQMTPAQFTSSNIVVTASDYELRARGRVIRFDGFLRVMPAIAKKDEDKILPDVKVGETLNLHQLDPSQHFTKPTARYTEASLVKELEKQGIGRPSTYAAIISTIQDRGYVHVENRRFYADKMGDIVTERLTESFSDLMDYSFTAKMEESLDVVAEGKKDWLSLLNNFYDDFMQKLDAAKAADTGMRRNEPVETNIECTNCGRNMQIRTGTTGVFLGCSGYNLPPKERCKNTMNLVAGEEAVNIDEDDEAESKQLRQKRRCKICNTAMDSYLLDETRKLHICGNNPDCSGYEVEAGSFKIKGYEGPVIECDKCGQDMQLKSGRFGKYFGCTSESCSNTRKLLRNGEAAPPKMDPVKMPELKCEKVDDTYVLRDGASGIFLAASQFPKNRETRAPLVKELLPHKDEIDPKYDFLMKAPLQDNNGLDTIVRYSRKTKEQYVQTEVDGKATGWKAFYEGGKWVISDEQKPKKPAKKAATKTKAKPKAKAKAKKDE
(1706) DNA topoisomerase [Burkholderia cenocepacia J2315]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDDFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPQAIRDGFANLRSDSDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFIPRDYWEVKAEFACAGGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLSTVQSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEFRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIPEVEELLQKKEIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMGKLLADGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDAETVTEGAEEKPAPARKTAARKTTARKTGS
(479) DNA topoisomerase 1 [Mycobacterium avium 104]
8
MADPKLKENTSGGNGSRRRLVIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPEKKHTVSELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPTFAARLTSVDGLRVATGRDFDSQGQLRKADEVIVLDEPQATELAAGLQGAQLSVASVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSGSAINAARTQARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSLRIGGQAGDRQVVFSASGRTITFPGFLKAYVETVDELAGGEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERRTDWLNNFYFGGEHGVADSIARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVGKNGPYLERMVTGDDGEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHEIVAKDGRYGPYVAEVLPEPPPDDDDGSGAPAKKGKKPTGPKPRTASLLRTMDLQTVTLEDALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRGNDSRSLATEEQLFDITLEEALKIYAEPKRRGRQGAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQRAAELLADRRARGPAKRTAKKTSRKAPAKKAAKRG
(1352) DNA topoisomerase 1 [Mycoplasma arthritidis 158L3-1]
3
MDQKVLIVESPNKVKTIQQYVGSDYNVVSSVGHILKLSTSGVDGLGIDFTNWEPMMIQDRTKAKVIKALKDATKNAKEVLIATDPDREGEAIAQNLVDTLKLSKIYRRIKYNEITAEAIKEALENPQMIDDNLVKAQKTRRMLDRIIGFRLSQLMKRKVKNAPSLPSAGRVQSIALKLVCDKEKEIKAFIPIKYNKIQAKISEDVIADFYYPTNSDFKNDNTWILPEKIDSIVAELNKNKSLLVKDFKVSQRKESQITPFKQSVLYKEAKYSATTVQISAQKLFEMGLISYPRTDSTRMSDTFIAKAREYIKEKFGENYVASDIKSFSGAQDAHEAIRPTDIYLIPQVAKTKYDLGEVESYIYTIIYNKTMSSLMTPPVREIYRYELVNGLYYFKMSYSKVIFDGYYRVLNFEEPKPLPKYEIGEAIPVLEFTRFDKETQPPARYNEGSLIKMLDDIKVGRPSTFASTINIIKKRLFVETINGALHPTVFGEVVLKKLIEGFPNTITEEYTAQVEEELDEVSEGKADYKILLEDFWNRFQRSYDDASKTIEISIMPQEFLERSCPRCGSTLLYRNNSKKHTKFIGCSNFPACRYSENADGTPTGQKTYKPRYYKKSSKAN
(627) Reverse gyrase [Thermotoga maritima MSB8]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(91) DNA topoisomerase 1 [Thermotoga maritima MSB8]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGVDLEKDFEPEFAVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGRKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITVNFDGLTAEIDVKEKKFFDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPEEAGKYLNSDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFPFEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFDRNDRIVVDFPTNQKCSCGKEMRLSFGKYGFYLKCECGKTRSVKNDEIAVIDDGKIFLGRKDSESGSPDGRSVEGKGNLSEKRRKGKKGS
(90) DNA topoisomerase 1 [Thermotoga maritima MSB8]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGVDLEKDFEPEFAVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGRKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITVNFDGLTAEIDVKEKKFFDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPEEAGKYLNSDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFPFEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFDRNDRIVVDFPTNQKCSCGKEMRLSFGKYGFYLKCECGKTRSVKNDEIAVIDDGKIFLGRKDSESGSPDGRSVEGKGNLSEKRRKGKKGS
(626) Reverse gyrase [Thermotoga maritima MSB8]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(1175) DNA topoisomerase 1 [Deinococcus radiodurans R1]
8
MGGPSVGQPQGKGPAGAAGRCVYAHRNFKPPAKVLTMPMPKTSPSKTLVIVESPAKAKTIEKYLGQGYAVESSVGHIRDLPRSAADIPEKYKGQAWARLGLDVEHDFQPLYVVSPEKKQKVAQLRKLAAEADEIILATDDDREGESIAWHLYQELKPKVPVKRMVFHEITREAIQAAIAAPRQIDRNLVEAQEARRAVDRLYGYEVSPVLWRKVAPKLSAGRVQSVATRMLVERERERMRFVAATWWDVVVTAQALTAQAGEQTFPARLTEVQGERLAAGKDFDPLTGQLRPGAGVRLLGEAEALAISEGLKGQTLKVLTAEEKPFTSRPPAPFITSTLQQEGSRKLRMSAQTTMRTAQRLYEGGYITYMRTDSTNLSSEAVNAARGQVKDMYGAPYLSPQPRVYAKKSKNAQEAHEAIRPAGSTFRTPEQLRGELSGDEWRLYDLIWKRTVASQMSDARGRSLRVRLGGQTASGQTADSVPVVLNASGRTIDFPGFLRAYVEGSDDPAAALEDRDTPLPPLKXGDAVRAQDVKAEDHETQPPARYTEASLVQALEGAGIGRPSTYASILGTIQDRGYALKKGTALVPSWTAFATSALLEHHFGTLVDYDFTAKMEEDLDEIAGGREHRVPYLRRFYLGEEGEGMALKPLIERQMGEIDARGIATIKVPKLEGSGIEVRVGRYGPYMQRGEDKANLPEGMTPDELTLEVAEELFSRPQGDRVLGEDPESGHPVLARAGRYGPYVTLGNENPPLRSASLFPGEKLEDMTLERALQLLTLPRLIGTSEGEEVWAHNGKFGPYLKRGSDSRSLATHEQLFTVTLPEAEALFQQPKFRGRGVAAAPLATYEYEGRTPILLKSGRFGPYLTDGEKNATLRKGEDLNTLDPQRARDILEERGKEPQKKPGKAGTKKAAASKAPAKAAASKTAPKKAAAKPAAKKAAPKKAASKSAKTPAAKAAPLTWAQLKPFVGVLSEPERALVTATREQGRKVEDVAPELGLDVKKAKGMALQASKKLNQAARGG
(1605) DNA topoisomerase 1 [Geobacter sulfurreducens PCA]
1
MSQHLVIVESPAKAKTIEKFLGPDYKVLASYGHVRALPSKQGSVDVEHDFEPRYAVLPESKRHIDAIKKELKASDSLLLATDPDREGEAISWHLLAALGVKPEKPPVPVRRVVFHEITKDAIVHAVENPRDISQDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFQSQEYWTIGAELAKEGGQKCTANLVEAEGKKLDKFDIPDQAAADRLVKALENATFTVDKVTKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMATAQKLYEGVAIDEGLVGLITYMRTDSVVLSNQALQEAHQVITSLYGPEYALAKPRFYKNKAKNAQEAHEAVRPTSIARTPAELKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGKGYRFRAAGTVIRFPGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLLKLLPEQHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLLERKYARLDSKRFIPEDVGMVVNDLLTNHFTTYVDYNFTATLEEELDQVSRGEKRWKPLLREFWEPFQGLLKQKEGEVSKADLTTEATDEACPECGKPLVVKLGKRGKFIACSGYKEGCTYTRNIDQGEGREQAEPVLSEEKCDKCGSPMLIKDGRFGKYLACSAYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPGPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
(1126) DNA topoisomerase 3 [Vibrio cholerae O1 biovar El Tor str. N16961]
10
MTRLFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKKWNMADLPIIPEQWQLRPRKSSSQQLTVVRKLLKEATQIIHAGDPDREGQLLVDEVIDYCKVPKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSALARSRADWLYGMNMSRAYTLLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFTLDALIPYQNGTEYFDIRARWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESEQDQTKQAAPLPYSLSALQIDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPKEHLAQAPDVVAAIANNAQEMVTAVNDADLSLRSKAWNDSKVDAHHAIIPTPKKASVNALSGHEMKVYQLIARQYLMQFYPAAIYAEAKLVFNIAGGIFIAKGRQLLSAGWKVLTGQQDEQEECVDKVPPLPVGIVLQCREGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKILRETDGLGTEATRAGILDTLFKRGLLQRDNKLIKSTPAGRGLIHALPSEATYPDMTAHWEHQLQAIAEKGQAYQPFMQTLQGRLEQLIEQVQVAPVPVSLQALPAVSKPAFKRTRRAPKSKARTYKA
(1611) DNA topoisomerase 1 [Vibrio cholerae O1 biovar El Tor str. N16961]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKASTTDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQPNVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHIVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECDKCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVLRDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFSRKEKEHYVRTETEGKPSGWMAVYQEGKWLVTDKRKNAK
(442) DNA topoisomerase 3 [Photorhabdus luminescens subsp. laumondii TTO1]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGDNQFVTWCIGHLLEQAEPDAYDNRFARWSLVDLPIIPEKWQLKPRPSVEKQLNIIQTLLEKADEIVHAGDPDREGQLLVDEVLDFLKLDAVRRKNVRRCLISDLNPQAVTRAVDRLRDNRDFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPILGLVVRRDEEIEHFVPKDFFEVKAHIVTPKDERFIAIWQPSESCIDFLDEEGRLIHRPLADHIVTRITGQPAYVISYQDKRESEVAPLPFSLSSLQIEAAKRFGLNAQQVLDICQRLYETHKLITYPRSDCRYLPDEHFAGRHAVLNAISIHATKLLPQELLEIDRKNRCWDDKKVDAHHAIIPTARSSHINLTDSEANIYGLIARQYLMQFFPDAIFRKCVIELEIAGGKFIAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKGDELLCERGEVVERQTQPPKPFTDATILSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKREFLYKKGRHIHATPAGRALIHVLPDMAALPDMTAHWESRLTQISEKQFRYQDFMGPLEETLQQLIWQAKQNRNLTAFRDLPPLPVKDKKGKKIKAPKNTKRAAP
(1735) DNA topoisomerase 1 [Photorhabdus luminescens subsp. laumondii TTO1]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSASQKSSSSSTDKSKKKVKKDEKAVLVNRMGVDPYRGWEANYQILPGKEKVVAELKSLAEKVDHVYLATDLDREGEAIAWHLREVIGGDGDRFSRVVFNEITKNAIKQAFDNPGELNIHRINAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPVEYWQLHADLLAKGEISLHMEVTHQQGKPFKPVNSEQTQAAVSLLEKARYKVLDREDRPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALDMVRDYISDNFGDKYLPEAANTYSSKENSQEAHEAIRPSSVDIVAEQLKDMDVDAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFELRAKGRTLRFDGWTKVMPVLRKGDEDHTLPVVEIGTELDLQQLIPSQHFTKPPARYSEASLVKELEKRSIGRPSTYASIISTIQERGYVRVESRRFYSEKMGEIVTDRLEENFNELMSYDFTARMEDQLDQVASNKVEWKGVLDEFFTDFSEQLDVANKEPEEGGMRPNPMVITSIECPTCQRSMGIRTATTGVFLGCSGYALSPKERCKQTINLIPENEILNVLEGDEAETNALRARRRCKKCGTAMDSYLIDSQRKLHVCGNNPACDSYEVEEGEFRIKGYDGPVIECDKCGAEMHLKMGRFGKYMGCTNETCKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKERLPEKLRYLADAPVVDAEGNKTVIRFSRKTKQQYASSEKNGKATGWSVFYVDGKWVEKDKK
(564) DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family [Myxococcus xanthus DK 1622]
7
MLAEKPSVARDIARVLGANERGEGWLRGNGYVVTWAIGHLVGLAQPHEIRADWKKWSRALLPMLPADWPLVVSKETRSQFEVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKCRKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSRADWLVGMNLSRLYTLAHGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALYKGTWFRSGPDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMAPPLLYDLTELQRHANRLHGFSAQRTLEVAQALYEKHKLLSYPRTASRHLSRTVADTLPEVVNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVRLSPDEQRVYDLVCRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPRLKSEGRKGEDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAMESAGRALDEKELADAMRETGLGTPATRAAIIEVLLDREYLRRRGKVMEATEKGIHLIQVVHPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAPQRPPRNEVLGAPPGAGWGQGGAAQVASEGAAAAHGAGAGARGPGGQGAFAESSAERFGDASAGGAGRGRQGAFTEASAERFADAAPGVQGQGRPGALSEASEPLFGTRRSRTSGSVGRSEPHGEPLSSTMSPGGGAASRLPRADGTGWNAGAWENTGAARAPVNRARTPASAASTGQRPERVRRAPTAPEALRPLLKEAFGFSDFRPYQEAVCRAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQVARLQSLGFAADRIHSGRDRAMSRQVCADYLEDRLDFLFIAPERLGVPGFVEFLARRTPALIAVDEAHCISQWGHDFRPDYRLLGARLPLLRPAPVVALTATATPDVQRDIVQQLGLQGPGGKARTFIHGFRRTNIAIEVRELNPGARGDAIQGLLEDEENRPAIVYAATRKHAEQLADQLAGEFPAAAYHAGLQPSERDRVQAEFLRGSLEVIVATTAFGMGIDKADVRTVIHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYIDRRTHEFFHRRDYPEAYVLERLFKSTAPQLEPKAVLQGRVRGDPEVFDKALEQLWIHGGVVMTPDETVMRGKPGWSASYSAQRDRKLLHLEQMGRYAEAHGCRMKQLVGHFGDTQDSGEPCGLCDVCAPEDCATLRFAEPTSAERHWLERILESLQERDGQATGRLHRELFGESLPRRDFERLVGGLVRAGLTRLEVDSFDKDGQVISFQRLALTDEGRRTRAVDPQRVVLPLPLEKAAKRKRGKGAEKGTAKRATAKKRTVRAKAGAATRRTASESDEEDSPTHWRANAPSKSTAGAPRASRSTGAPSGSASGRRAAAEPSPKMVEALKAWRLAEARKRRVPAFRILTDRVLEAIASACPENGSELMAIHGVGPSLTERYGAQILSLVARRS
(996) DNA topoisomerase 1 [Myxococcus xanthus DK 1622]
1
MGIERGTGMADAETDILTAEQQACLALWAVPGLGPRTLVALRAFADGSLAPLAATPVRDWVSQAPVSSQVRRKLASVERLAPVAWRVWEACRASGMKVAFQGQAAYPERLAEVEDAPPVLFYRGVPGLPRRRLAMVGSRHPDQGFLPFARRFARQVAASGVGVVSGAASGVDRACHWGALDEGGETWAFLGSALDALDTAQARLLPHFLDRGGVFFSELPPGVRASTTTFPRRNRLISGASDAVLVLRAGKDSGSLYTAEAGRAQGRPVFAMPGDVRQEEAAGCNALLRNGEAAVCLGPDDVWRVLKVDPLAAVPPGTMGSWEDLSAEAKGGLRDVGPGSPELRRGAGRQHLLTGGARQRAGGVGIDGAGHPAPRKAVRENLGRRVMATRTKKKVEETEAAEEKAPAKKAAAKKAAKKKPAAKKKTAAKKTAARRRTKKGDEDELPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREGEAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQISPLLWKKVRRGLSAGRVQSVAVRLIVEREDEIKAFVPEEYWTLDALLEGPAGPPPFKAKLSKLDGKKVELKERVFTESLVAELQTASFSVAKVDRRERRRNAPAPFITSKLQQEAANRLSFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFLPDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKPFFEAMGEEDMYRLYELIWKRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEGADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVMVEEETTDEVCEKCTKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRDGPYVACPNKECDYRREITEQPGGPGGSPEASSAA
(815) DNA topoisomerase 1 [Lactobacillus johnsonii NCC 533]
1
MPTKRKNKKNLVIVESPHKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGVDVEHDYEPKYISIRGKGDTIKELKSEAKKAKYVYLASDPDREGEAIAWHVAHALNLDPKEHNRVAFNEITKDAVKNAFKNPRTIDMDIVDAQQARRVLDRLVGYSISPILWQKVKKGLSAGRVQSIALKLVIDRENEIKNFKPEEYWTIDADFEKGSEKFKGAFYGIKGKKQELPNNEAVQDVLKRIDKRKNFEITKVVKKERRRQPAAPFTTSTMQQEANKRLGYRTRRTMRIAQSLYEGVNLGKGSVGLITYMRTDSKRIANVAKHEASKFIHEEYGENYAAVKPQHFKNDADAQDAHEAIRPTSAFRTPASVKEYLTTEEYRLYTLIWSRFIASQMTPAVYDTVRADIEQNDVTFRTTGSKLKFAGFTKVYDNQKEKSNELPELNEGDKVKLKKTDDRQHFTQPPARYTEASLVRTLEENGVGRPSTYAPTIDTIQKRYYVKLEGRSIVPTELGEIVDKLIEEFFPDIVNVDFTAQLENDLDGVEVGKKNWIKVVDEYYKPFSKELDKADQQIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKIGVTCPKCGKGEVIEKKSKRNRKFYGCSRYPDCDFVSWDQPIGRNCPNDGHFLVQKKNKKGLVILCPNGDYREEPEEN
(1339) DNA topoisomerase 1 [Gluconacetobacter diazotrophicus PAl 5]
1
MTDVVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDENFAMDWQADERGSRQMAAIAKALRGARHLYLATDPDREGEAISWHVRAMLEEKNLLKGVDVQRVTFNEITKSAIRAAMAQPRDLDQPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIESFRAREYWTVAAQFTTPGGAAFTARLTHLAGCKLDQFDLHDEAGAMAAKAAVEAGRFAVQSVERRKVRRNPPPPFTTSTMQQEASRKLGMGAQGTMRTAQQLYEGIDLGGETVGLITYMRTDGVQMAGEAIAAIRGHIGESFGAPYVPEKARIYSTKAKNAQEAHEAIRPTDVSRTPAQMARYLNDEQRRLYELIWKRSVASQMQSAELDQVIVEIADAGGAATLRATGSMIAFDGFLKLYSEGRDDAAPKDEQDDDSRMLPPMRERDALKTGEVAADQHFTQPPPRFSEASLVKKMEEIGIGRPSTYASILTVLRDRNYVRLDARRFVPEDRGRLVTAFLTSFFERYVDTQFTAGLEEQLDDISGGRADWRDVMSAFWQDFSRAVDQTKDLKISDVISALDADLAPHFFPAHPDGSDPRVCTACGTGRLGLKLGRYGAFIGCSNYPTCQFTRRLVVDPKEDGEADTLKDGMRLLGQTPGGEDVTVRRGPWGLYVQQGEPDPEDKKAKPRRATIPRGIEGDKITLDQALGLLSLPRVVGIHPETGEQIEAGLGRFGPYVKMGAVYGSLDKDDDILTVGLNRAVDVLARKLASVRTIAPHPKDGEPVIVRKGRFGPYIQHGTMVVNVPRGEAMEDVTLDQAVALLAEKGKPLKPKGKAAAKKAPARKTAARKAPAKTAAKKAAPDGDADTQARAAKPPARKAAARKTPAGKATGKTAKGKAEPGEGAGPRTRRTATEAG
(45) DNA topoisomerase 1 [Gluconacetobacter diazotrophicus PAl 5]
1
MTDVVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDENFAMDWQADERGSRQMAAIAKALRGARHLYLATDPDREGEAISWHVRAMLEEKNLLKGVDVQRVTFNEITKSAIRAAMAQPRDLDQPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIESFRAREYWTVAAQFTTPGGAAFTARLTHLAGRKLDQFDLHDEAGAMAAKAAVEAGRFAVQSVERRKVRRNPPPPFTTSTMQQEASRKLGMGAQGTMRTAQQLYEGIDLGGETVGLITYMRTDGVQMAGEAIAAIRGHIGESFGAPYVPEKARIYSTKAKNAQEAHEAIRPTDVSRTPAQMARYLNDEQRRLYELIWKRSVASQMQSAELDQVIVEIADAGGAATLRATGSMIAFDGFLKLYSEGRDDAAPKDEQDDDSRMLPPMRERDALKTGEVAADQHFTQPPPRFSEASLVKKMEEIGIGRPSTYASILTVLRDRNYVRLDARRFVPEDRGRLVTAFLTSFFERYVDTQFTAGLEEQLDDISGGRADWRDVMSAFWQDFSRAVDQTKDLKISDVISALDADLAPHFFPAHLDGSDPRVCTACGTGRLGLKLGRYGAFIGCSNYPTCQFTRRLVVDPKEDGEADTLKDGMRLLGQTPGGEDVTVRRGPWGLYVQQGEPDPEDKKAKPRRATIPRGIEGDKITLDQALGLLSLPRVVGIHPETGEQIEAGLGRFGPYVKMGAVYGSLDKDDDILTVGLNRAVDVLARKLASVRTIAPHPKDGEPVIVRKGRFGPYIQHGTMVVNVPRGEAMEDVTLDQAVALLAEKGKPLKPKGKAAAKKAPARKTAARKAPAKTAAKKAAPDGDADTQARAAKPPARKAAARKTPAGKATGKTAKGKAEPGEGAGPRTRRTATEAG
(157) DNA topoisomerase III [Bacillus halodurans C-125]
7
MGAVVVIAEKPDQGMKLAAPFPHRNKRGYVEVAPCDQFPAGAFFTWAVGHLCELCPPEQYDPSWKKWTLEALPLIPQSFVHRVSRGKKDQFQVIRSLVHRKEVTEIVMAGDAGREGELIVRLILKQCRVKKKTSRLWLSSLTKQAVVSGFHQLKSAESTEPLYHEALSRSCADWLIGMNVTRAYTLLLKKKGVDSLFSTGRVQTPTLALIVKREKEIEAFESKPFWEVKATFRVQGHEYEGIWHKDRETRLFDQPMAEAIAAFCRGKQGKVTKVKKETKTLKPPYLFNLSSLQATANKRFTFSPKKTLDVAQKLYVKGHISYPRTDSSFLTAEEGKAAKRIVQLLKQEDAYASLFPLDRDNLLQDRRYVNQSKVTDHYAIIPTDDVPKVQTLAKDEQLLYDLIVRQFLAAHMREAKIAYTEVETLVDERATFLTKGKQLLDQGWKQIIGLSKDDKDEDIPPLEEGWTGDVKHADVREGKTKPPSRYTEGQLITLMKTVGKHVEDDELEKVLMRTEGLGTEATRAGIITLLKDRQYIEIKKNVVYATEKGKLLIEALGPSLLASPEMTAKWEQRLFEIGRGQADAHAFMEQVKKLSDHLVKEAHQRANTWDFSSFDQEALEEKTKKRKKRRPTYVGSCLACDGKLLDRGEFYGCTNYEAKSCRFTISKTILGKRLSQANVKKLLQGETTNVIKGLKKGSDTFDAKLYWDKEKKKLGFQPVES
(1137) DNA topoisomerase 1 [Bacillus halodurans C-125]
1
MADYLVIVESPAKAKTIGKYLGKKYTVKASMGHVRDLPKSQMGVDIEDEYSPRYITIRGKGPVLKELKSAAKKVKRVYLAADPDREGEAIAWHLAHSLDIDETSECRVVFNEITKQAIKDAFKSPRPINMDLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIDREKEIQAFEPEEYWSIQGTFALDGEPFEAKFYGTNGKKVELKSEDDVNNVLAKLKGDQFHVDSVQKKERKRNPVSPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKAETKEYIESKFGKEYAQNGTKAVKKDKKSQDAHEAIRPTSVERDPKSLKEYLSRDQLRLYKLIWERLVASQMAPAIMDTMTVDLSNEGVLFRATGSKVKFPGFMKVYIEGNDEGKKEEDRLLPNLQEGQTVTKEEIEPSQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQKRGYVALDERRFVPTELGEIVLELMTEFFPEILDVEFTAKMEDDLDSIEEGKQQWIKIIDDFYKGFEERLKVAEEEMKEVEIKDEPTGEMCEKCGHEMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPKCEKGEIVERKSKKRRVFYGCNQYPECDFVSWDKPIARSCPKCSSYLVEKRTKKQVQVQCSSCDYKEEAN
(469) DNA topoisomerase [Desulfitobacterium hafniense DCB-2]
7
MGKTLIIAEKPSQAREYAKTLGVKGKREGYFENDEYIISWCIGHLFELKAPENYMDLPKVGKRWSIRRLPVLPRLGEFQYGLKSGTAKQFKVLQGLLRSPEVQQVICGTDADREGQLLFQEVWDAVGSKKPLFRLWISSLTQEAIREGMSKLRPVGEVEGLAQAGYGRSYGDWDFGMNLTEGFTALFGSFDPVRKKPNVISIGRVQTPTLALVVEQEWAIENFVPVAYVEVEAEFASGQGSYKGKWFDPAVKNTRDKNQETDNAQMMLDLDRGKEIVAKVQGKPGRIRSVKDKETKEPHPLLFDLTSLTVSASKRYGFGAEKVLKIAQSLYEKKAITYPRTDCNYLPPDMLPKLKVHLQALEQSPFASWVKEALDNPLPGGKRVINEITAHHAIIPTTEKMIPNLSPDERKIWEMIVLRFLCIWFPPARYAEKEVVTVVEEEFFLTKGKTLLESGWKKIENTEKYTEGSGLQLPLLQQNEEVVTRSCQALQKETKPPKRYTQGDLIKAMEGAGKEIEDETLRRQLKGKGLGTVATRGAIIENLLDRGYLLQQQKVLVPTAKGTELIRLIKERLPRAQLLISAEMTGQMEYELAQVERGELPLSRYMEKVEEAIRGIIEELRHYEATRGKKPLAFAPQKAGASGRKSKSNLEEKPQELPVQAKVTKAAKTRQESPASAAEENLGICPSCGGGVVEREKGYGCQNWKNGCPFILWKNPICGKVLTPAQVKSLLKKGKTNLIKGFRSKNGSVFAAYLVWEDPSSGKLKFEFENNDRAKPG
(616) DNA topoisomerase 1 [Desulfitobacterium hafniense DCB-2]
1
MAKTLVIVESPAKAKSISKFLSNNYTVKASMGHLRDLPKSQMGVDVDNDFEPKYIAIRGRGDLIKELRAAAKTANKILLASDPDREGEAIAWHLGHLLGLDLAEKCRIEFHEITKPAITAAIKHPRQIDSSKVDAQQARRVLDRLVGYQLSPFLWRKVKKGLSAGRVQSVAVRLICDREEEIREFIPEEYWTLTASLKSEGGVFSAKLARKGEHRIAIASEEEMQKVLQELADQTYRVKDVRTKEKKKQPSPPFTTSSLQQEAHRKLNMSPKRTMMLAQQLYEGIELGKAGGIGLITYMRTDSVRISETAQEEAKEFIAEHYGADYYPPEPRQFKSKGRAQEAHEAIRPTSILRTPDSVKEFLSRDQLRLYRLVWERFLASQMSAAVLDTLTVEVEAGEYLFRANASTVRFPGYLAVYEDGQDENDDQEEGTLAANIQPDESLNVLQLQEKQHFTEPPPKYTEASLVRKMEEEGIGRPSTYAPTIETIQSRGYVAKEGKQLSPTELGEIVVSILKEYFPEIVDLEFTANMEKRLDDIEEGALPWKAVIRDFYGPFAESIEEADQVMGKVQIEDKVSEEICENCGRNMVIKMGRYGKFLACPGFPECRNTKPLLEEVGRPCPDCGNPLVIRRSKKGRKFYGCSTYPECEFVSWELPAPEPCPKCGGLMVVKTSKQGQKYVCTNSECRFDKQVEEQAE
(1667) DNA topoisomerase 3 [Desulfitobacterium hafniense DCB-2]
2
MGKSLVLTEKPSVGRDIAKLLGCNQKGNGCFIGSRYIVTWALGHLVTLADPEAYGEKYKQWRLEDLPMLPKDMELVVIKETSKQYAAVKQLLRQPDVEELIIATDAGREGELVARWIIGKAGWKKPIKRLWISSQTDKAIREGFNNLKPGKAYESLYAAAECRAQADWYVGLNVTRALTCKYNAQLSAGRVQTPTLALVVEREKEIQNFVPKGYWTINARVQGFSLSWQDKGNGQNRMFDQRKAEQLVQKLRGHKGQVAEIKKEAKREQPPQAYDLTELQRDANRKYGFSAKQTSSIMQQLYEQHKLVTYPRTDSRYLSEDIVPTLPERLKTIAVGPYSELARRVLRTKITPTKRLVDNSKVTDHHAIIPTEQTVFLNKLSPEEAKIYDLIVRRFIAVLSPAFEYEQTTVKVEIQGELFTAKGKIVKQKGWRSVYEGREAADEEADHEEQEQNLPDLQPKQTLEVLDLKLLPGKTKPPKRYTEATLLSAMEHPGQRVNDEALRETLEKTSGLGTPATRADIIEKLFSSFYMERNGKEIVPTSKGIQLIGLVPSELKSPELTAKWEQQLSEISKGREDRQRFIQGIKSYATQLVSEVSGSGRTYRHDNMTRAKCPECGKFLLQVKGKRGEMLVCQDRECGYRQGLSVQSNARCPQCHKKMKLQGEGEHKIFTCACGYREKLSAFNKRREQEGSKGSYNKREVNHYLQKQEKDAPLNTALADALAKLNLPK
(1541) DNA topoisomerase 1 [Mycoplasma penetrans HF-2]
3
MDKLLIIESPNKIKTLTKYLGKDYEIIATIGHIRDLNQFGMGFDADFEPKWVIPSVKKNSKNKNEVSKKEIVEKLKKSASKAKEIYIATDPDREGEAIAWHVYEVLDAASQKKCKRITFNEITKNAILESLNHKRDIDINWVQSQFARRIIDRLIGFKLSKLLQTKLKADSAGRVQSVALKFIEDREKEIRNFVAENWWTLDVMLEDNNSLILKSIDPNLKNIKLSEKKFSTSGLDIADEESANNLLNALDKKFKVKSIEEPSFYSSYPKSPYKTSTLQQDAINKLGWNSKKITLIAQHLYEGVEVDGNQIALISYPRTDSLRLSDTFVQSAFKFIEETYGKDYVGKYQVKSSANDANTQDAHEAIRPIDPYLTPQELKNKISKDEFALYQLIYNRTVASLMAAAKFKKVTIKFDNNNCEFYTFSRECLFLGFKKLYVEDNEDEENKLIDLNNYPVGKEFKSKVMEVKKHETQPPQRYTQATLIGDLESAGVGRPSTYSSMANIALERGYAVTDKKAYVMTDIGKIVVDQLEKFFPDIINKDFTKKMEEHLDQIASGNEEWKSWLKKFAPGFDEEVKKAYDTMEKISDEKVGRECPKCGKDLLYKRARRGGSKFIGCSGYPECTHLEPLEKPEELEISCPECGSKLLKRKSKRQQVFVGCSSWPKCNYIISDKLFDKHMKETPDKPLPSKKELEEIRAARLPKWKKN
(809) DNA topoisomerase 1 [Lactobacillus acidophilus NCFM]
1
MPTKAKSKSKTKKRKKILVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDNYKPKYISIRGKGDTIKELKSEAKKAKEVYLASDPDREGEAIAWHVAHALDLDENAKNRVTFNEVTKDAVKESFKHPRSIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWSIDAEFSKGKDTFKSSFYGIDGKKKELPNNDAVKEVLAKIDKRKNFEVENVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKEGTVGLITYMRTDSKRTSPVAQQEASKFLHENYGAEFAAKSQRHFKNQEDAQDAHEAIRPTSVYRTPESLKSVLTTEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVMFRTTGSKMKFPGFTKVYDNQQEKSVDLPDLQEGDKVKMTKSDNKQHFTLPPARYTEASLVRALEENGVGRPSTYAPTIDTIQRRYYVKLDGRSIVPTELGEIVDTLIEEFFPDIANVDYTAHLENELDEVEDGKKEWVHVVDEYYQPFKKELTKADSEIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKEIGVVCPKCGKGEVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKHSKKGPVVLCPNGDYKEEPQEGETDK
(950) DNA topoisomerase 1 [Rhodobacter capsulatus SB 1003]
1
MAVVVVESPAKAKTINKYLGSDYTVLASFGHVRDLPPKDGSVDPDADFEMKWEVAADSKKHIKAITDALANDDELILATDPDREGEAISWHLQQALASKLKKKKVSRVTFNAITKSAITEAMKAPREVDQALVDAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVCLRLIVEREMEIEAFRAREYWTVTAELTTPRGQTFTARLTVLGGKKLDKFDLTTATDAELAVQAVTSRDLTVKSVEAKPATRNPYPPFMTSTLQQEASRKFGMGAKACMSAAQRLYEAGHITYMRTDGIDMAPEAVMAARDEIKRRFGDKYVPSSPRMYKNKAKNAQEAHECIRPTDMSQSPDKLKLADDQWKLYDLIWKRTLASQMSAAVMERTTVDVGSKDNEVELRATGQVVTFDGFLKIYDQGRDDDEGEDGARLPQIMQGEPAQKGAITPEQHFTQPPPRYTEATLVKRMEELGIGRPSTYASILTTIVDRGYVRKDKNRLIPEDTGRLVTAFLSNYFRRYVEYDFTADLETELDDISAGDRPYRDVLARFWRDFSAALAETADLRIGEVLSKIDEVLGPHLYPARADGSDPRSCPVCSAGRLHLKTARSGGAFIGCGNYPDCRYTRPLSAPADGEAGVLDGKVLGEDEGAQITLRVGRFGPYVQKGEASEEIPKPPRASLPKGWSPESIDLERALQLLNLPRPIGNHPEDGALVEAGIGRFGPYVKHNSTYANLPDVEEVFTIGMNRAVEVLAQKLARGGARGSAAAAQPLKDLGEHPEGGVVQVMPGRYGPYVKWGKVNATLPKGTEPEAMTLEEALPLLEAKASKGGKKAAPKKAAKPAAEKKPAAKKAATKTATKTAAKKPAAKKAAPKKAAPEADVVED
(1113) DNA topoisomerase 1 [Wolinella succinogenes DSM 1740]
1
MKNLIIVESPTKAKTIKNFLGKEYEVIASKGHIRDLPKHNFGIKIEGQSFLPDYKIEKGHEAVVKEIKALAQKAKTIYIATDEDREGEAIGYHISHAIDKDPTTLPRIVFHEITQNAIKHALETPRSINMDMVNAQQARRLLDRIVGYRLSPLISSKIQKGLSAGRVQSSALKLIVDREREIRSFVPVTYFTIEALFEKGIEAELIEFEGEKLEKLSIGESKKANEMVKVLQKESWSITGIEHKRRKTSTPPPFMTSTLQQSASSVLGFSPSKTMMAAQKLYEGVMTHQGVMGVITYMRTDSLNIAKEAQEAARSRIKEVYGERYLPKEPKVYTTKSKSAQEAHEAIRPTLIDFTPQLAAQYLKGDELKLYSLIYNRFLASQMNDAEFELQTILLGSSKGVFKVSGRKLIFDGFYRVMGSEDKDKLLPELQKGEALKLEECKANRHETEPPARFSEASIIKTLEALGIGRPSTYAPTISLLAGRDYIRIEKKQIIPEEVAFKVIEVLEAHFTEIVDSHFTATLEEELDEIAESKKDWQKVLWDFYEKFDAKIALGKKNIESQKVAIPTGEMCPKCGAELVRRMSRYGEFVACSGYPKCKYIKPQESSPEQEGEESEEVCEKCGKPMVKKRGRNGEFLACSGYPDCKNTKSLKKSSTPKKVLEVKCPKCGGEIIERSSRRGNFFGCANYPKCDFISSHEPINEKCQKCGGMMAKRTYRKKEVHECIACKDRIEVEERNEEEK
(1029) DNA topoisomerase 1 [Chlorobium phaeobacteroides DSM 266]
1
MALKSPAASARNRTLIVVESPSKAKTINKYLGDKYTVFASVGHIKDLPKKEIGLDFDHHYEPRYEVIAGKEKVVRQLKKLADESNEILIATDPDREGEAIAWHIANEVEFAHKPVFRVLFNEITKTAIIAAIQQPRQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVLRGLSAGRVQSVALRLICEREAEINGFQIQEYWSIAADFKTDLNETFRTKLIKIKGDKPELSNQKKAETAAAEISERLFAVKEITTRVQQRKPPFPFTTSLLQQAASNQLGFGSQKTMRIAQQLYEGIELGDEGATGLITYMRTDSIRIGTEATAEARNYITAQFGKEYVGYGGAAKAGKNAQDAHEAIRPTSLLRKPESVKHFLSSDQFRLYELIWRRLLTAMMAPAKIEQTRVDVEDREKEFTFRANGSRVLFAGFMRVYDDQQELDYEAQSSTRDDVEKEQTVQLPEKLKEQDKLGLAGLDSKQSFTRPPARYSEATLVKDLDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTELGKDVSLILVANFPELFNVGFTAHMEDELDKVASGDDEYEAVLEKFYRPLETALSLRKSDPIIPQNSATETCDKCGKGQMTVKWTASGKFLGCSRYPSCKNIKPLSSSKAKPKDTGIQCPSCKEGHMLLRDGRLGPFLACSSYPKCNTLLNLGKQRQVEPMKIPPLLTTLVCPKCGAPMNLRSGKRGLWLGCSKFPKCRGRLAWGTLDEEVQRHWETLMTEHQKAHPTVALTMIDGRPVPLTLSVDDIITRAEEAGLIAAVPEEQQELTAE
(547) DNA topoisomerase 1 [Salinibacter ruber DSM 13855]
1
MKRLVVVESPTKARTIREFLPETGYRVEASMGHIRDLPASADQIPSEYKDEDWSRLGVKVTNGFEPLYVVPPDKKEVVRDLKQAVSDADRLYIATDEDREGESIGWHLIHTLDPDVPVERMVFHEITEDAIQRALDDTRDIDQHLVEAQQTRRILDRLVGYSISPLLWRKIKPKLSAGRVQSVAVRLLVQKERERITFVPATYWDLDAQLAKQGIGVEAEMTHLNEVRLASGKDFDEDTGRLKESLTEGEDVVLLDEEQATALAEGLPETRWRIDDIKERTRTKSPFPPFITSTLQQEANRKLNLSSSRTMSVAQSLYENGYITYMRTDSTNLSSEAVEGARRTVAQRYGDEYLSDGVRQYSSSDSAQEAHEAIRPAGSEMKTKDELGLSGIEAALYDLIWKRMLATQTADAKVRYTNVYFDAEVDGDVARFRASGKRLDFPGFFRVLVEGSEDPEAALRDQERPLPPLEVGETAAQSADDDGFQVRSVEPLGHETKPPSRYTEASLVETLEEEGIGRPSTYASIIGTIQQRGYVRKKGSALVPTFTAFATNNLMETQFEPLVDVHFTAEMEDVLDDIARGRKDPTPYLRDFYKGEEGVETRVEQGLDDIDPKQISEMSFPDQWGEYVVRVGKYGAYVEGEMDGATVTASIPDDLAPGDTTEERLREILEEANRGDRVLGIHPEASLPVLLKSGPYGPYVQLGDDEEEDDPKRVSLPPDVEPEDVDFDLGVRIVDLPRTLGEHPDTGKEIEADIGRYGPYVRHEGTFASLQKGDDVLEVGLERALELIRRKEARNEPDRVLGPHPGSDEPVEVWNGRYGPYVKHDGTNASLKDDQSIDDVTMDDALDLLAEKGDEATQKVRE
(1106) DNA topoisomerase 1 [Thermotoga neapolitana DSM 4359]
1
MSKKKKYIIVESPAKAKTIKGILGPEYEVFASMGHIVDLPKSKFGVDLKNDFEPQFTVIKGKEKIVEKIKAISKVGEIFIASDMDREGEAIAWHVARLTNTLGKRNRIIFSEITPRVIKEAVKNPRKIDMNKVHAQLARRILDRIVGYSLSPVLWKNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRVVVKFHGLEAEMITKEKTFLEEDVLKELQSIEELVVEEKTVSRKKFSPPDPFKTSSLQQEAYAKLGFSVAKTMLLAQQLYEGVETKEGHIAFITYMRTDSTRVSDYAKEAARELIEKDFGKEYIGTGRRKKSRTARIQDAHEAIRPTDVFMTPEKISKYLNPDQRKLYELIWKRFFASQMKPSEYEETRFVLRSKDGKYRFKGSILKRIFDGYERVWKTERNVGDFPFEEGEIVKPVEVEIKELETKPKPRYTEGTLVKEMERLGIGRPSTYASTIKLLLSRKYVKKIRGYLYPTVIGSVVMDYLEKKYADIVDISFTAEMEKELDEVEQGKKTDKVVLQDFYRTFSKVFNENDRIIINYPTDQKCSCGKDMVLSFGRYGFYLKCECGKSRSVRNDEVAVIENGKMFIGRKNDEDSTSDGGNVKRKRSLTEKRRKGKKSS
(1506) Reverse gyrase [Thermotoga neapolitana DSM 4359]
6
MAVNLKYHHSCINCRGVNTDERNERGLPCEVCLPEESPSDIYEALLERRTLKDYRFYHRFWREYEDFRNFFKEMFGKNLTGYQRLWAKRTILGKSFTMVAPTGVGKTTFGMVASLWLARKGKKSALIFPTVTLVKQTLERLRNMSEDAKIIGFYSSMGKEEKKKFEESFEKDDYHILVVSTQFVSRHREELSRKKFDFVFVDDVDAVLKASRNIDTLLMMVGIPENVIKKALSAIKQGKIYERPDNLKTGILVVSSATARPRGIRPLLFRDLLNFTVGRLVSVSRNITHVRISRKSRERLVELLRVFRDGVLIFTQTEEEGRNLVDYLKGQGIRVEGTWERFEENFDAFKNGDIDVLVGVQAYYGKLTRGVDLPERIKYVIFWGVPSMKFPLELDRAPKFVLTRLLRESGLIKGREVNEEELRKLAKSHFSQEEFVERVKEIFRGSAVRGEELIIPDIYTYIQASGRSSRILNGVLVKGLAVIFEEDEEIFESLRTRLLLVAEEEILEESEVDWEKLIREVEESRKSLKKEFSDTSRSLLIVVESPTKADTISKFLGKSSSRRERNILVHEAVTDEGIILFTATRGHVYDLVTRGGIHGVEEKNGIFVPVYNSLKRCRSCGYQFTEDREECPICSSKDLDDKTETLRALREISLEVDEILVATDPDVEGEKISWDVTQYLIPANGSLKRIEMHEITKYGFKKARESVRFVDFNLVKAQVVRRIQDRWIGFELSGKLQKQFGKPNLSAGRVQSTVLGWIVDREEEYRKSEKNFTLITLENGAQLEVEGKVSVDAISVSKVEETEEDIAPPPPYTTSSALSEISQKLRLGVQETMDILQDLFEKGFITYHRTDSIRVSLEGQNVARSYLRKIGKEELFTGRSWSTEGAHEAIRPVKPIDDKEIEEMMEEGLITDLTKKHLRVYSLIFNRFLASQSSPVKVKRQSVFFDVEGKELKKEYVVEILKDGWNLFMPLTISPRFEHRSYRILERKIYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFKRGYVYEDKYRRIRPTKLGVMVYSFLKERYERFVTEETTRRLEEIMDRVEKGEEDYQSTLRLLYEEIKSLTEEG
(1788) DNA topoisomerase 1 [Dictyoglomus thermophilum H-6-12]
1
MSKEKLIIVESPAKAKTIEKILGKDFKVLASYGHIRDLPEKELGVDIENGFKPKYVLLPSRKKIIDTIKDLSKKVEKLYLATDPDREGEAIAWHLVETLKLPKDKFTRIEFHEITPRAIQEAIRNPRDIDLDKVEAQQARRILDRLVGYELSPLLWEKVRRGLSAGRVQSVALKLICEREEEIEKFVPEEYWYIYGEFEDKDKIIYGKLVFYKEEEITIRNEKEAKRLIEVLNNLEYKIDRVVIKEEKKTPPLPFITSTLQQEASRRLGFPVSKTMKIAQSLYEGVDIGDERVGLITYMRTDSTRIAPEAREEAVTYIESVFGKEYVGKERKERKKLGMQDAHEAIRPTSVLRTPEKVKKYLTEDQYKLYKLIWERFLASQMANALYDVIEIDIKGGDYTFVSKGRKLKFAGFMSLYTEKEEEEEEEVNVDYIPQEGSDIDLINLTPKQFFTQPPPRYTEATLVRTLEKYGIGRPSTYATIIETLKERKYVEVSKKELVPTTLGKVVNEFLTKQFPHLIDVKFTAKMEEDLDKIESGEVKAIEVLEKFYPSFKEELERVSKNFGKIQVVEKTDEFCPICGRELVIRENKHGKYYACSAYPECKYTKPIYEEAHGKCPLCGGIVVKKKARKTGKVFWGCINYPNCSFASPYEPLDEKCPQCGSVLLKGNGFKKCSNENCNYIVWVGRRKRWKKSK
(647) Reverse gyrase [Dictyoglomus thermophilum H-6-12]
6
MIEAIFKGLCPNCGGDITAERLLAGLLCEKCLPEKVPQEALCNHIKEQDYDLCTLRKRYSEWEKIFRNFVGFEPWELQKFWAKKLLLGRSFALLAPTGIGKTSWGLATSLYFAEKGKKSYIILPTRLLILQSYEKLKGKIREKDLLVFGLDENKKEKEEKRERLQEGDFKILITSSMFLYKNVDAIPRDFAFIFVDDVDSFLKTAKNIDKALYLLGFSEEDINFTMSYIRMRRNGGDQENIKEVQEKVREIAKKARGVMVVSSATSNPKSERIRLFKELLSFDVGRPIFYLRNVEDVYEETNDLNKTLVERVKRFGKGGLVFLSSDFGKEYVDDIKNLLISEGITAESYDNLTPEVLEKYQKGEISVLIGISSYRNPLARGLDLPEVIRYAIFYGVPKIVVNLDIEGNVRHLLVALASIRPLIARDKNLEKHIANVDRWMKNLKKYSAVLNPPKDKVDELRNTIKAFILSPEIYEKIKSADDIAIREENGKWILVVSDITGYLQASGRTSRLYVGGISKGLSYILVDDRKVFNNLVRKSRWWFSTDIVFKEASTVDIDDIFRQIDEDRERIRRKEGRRDDFLKPVLVIVESPHKAWTIANFFGRPISRNVNGQELFEVITEDKYLVITASFGHILDLNKEIGYFGVIENGKFVPVYEPIEEKERIISGIRDASKEFDMILVATDPDTEGEKISWDLKNLCAPFTKEIRRMEFHEVTKKAILNSLKESRDVDENLVKAQVVRRISDRWVGFELSQLIQRIFSKNYLSAGRVQTPVLGWVIERAKENKKRIYIVVIRKDGLDLRFDFENKDEAQDFYNNLKYIQIIKDAEKIEEKGPLPPYTTDAILKDASDRFKLSVSRTMEVLQELFERGFITYHRTDSTRVSDTGINLAREYISEQFGEEYFRGRTWGEGGAHECIRPTRVLDVEDIKAMIYSGELEGFTPDHLKIYDLIFKRFIASQMRNVVLKGYEVVVKALDKEQRLELYEEILQDGFDKIFPVKLTRLPDGEIDVINNKFFYSIPKVPLFTQGSLVEEMKKRGLGRPSTYATIVSRLLERGYVIEKNGYLIPTPLGEKVYQYLNSDQERFRFVREDFTRELEELMDKVETGEKDYQAILRSLRNELKKV
(1881) DNA topoisomerase 1 [Frankia alni ACN14a]
8
MPATRPSSRAAAGRAATGRRPTSRSATGSGGSTGAAAEPTPGSGTRLVIVESPAKAKTIAGYLGPGWQVESSIGHIRDLPRSAADVPAAHKGKPWARLGVDVDNDFEPLYVVTPDKKLQVSKLKALVKEASELYLATDEDREGEAIAWHLLQTLKPTVPVKRMVFHEITPQAIRRAVDNPREIDENLVNAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRVLVERERARMRFRAAEYWNIEGLFGATVARQAWPAGTDGADADATGGGVERTPLPATLVALDGNRIATGRDFAPTGELTTSGVTRLDEAGARALTDRLAQAAFAVRSVETKPYRRSPYPPFMTSTLQQEAGRKLRFSSQRTMQIAQRLYENGYITYMRTDSTNLSETALAAARSQAESLYGPEYVPASPRTYTKKVKNAQEAHEAIRPAGDHFRTPGEVRGELDVDSYRLYELIWQRTVASQMADARGTSATIRLGATSSTGEDAEFSASGKVITFPGFLRAYVEGADDPDAELEDRERRLPDVRQGDPLAVRSLTPRGHTTSPPARFTEASLVKTLEELGIGRPSTYASIIGTIQDRGYVWKKGSALVPSFVAFAVVGLLEDHFGRLVDYRFTATMEDDLDDIAAGTSASTDWLTRFYFGTGDGTDPATAAGLKHLVSERLGEIDAREVNSIPLGKADDGTTVVVRVGRYGPYVQLGEGRASVPDDLAPDELTVARALELLAAPSGDRVLGVDAATGATITAKAGRFGPYVTTDTDPPRTSSLLRTMSLETLTLDDAVKLLTLPRTLGAGADGEEVTAQNGRYGPYVKKGAESRSLESEDQLFTVTLEEALALLAQPKARGRRQAAQTPPLRELGNDPASGKPMVVREGRFGPYVTDGETNASLRKGDAVESITDARAAELLADRRARGPAPAKRAARGTAKTTATKTTATKTTAAKSSAAKTTTAKSTTAKTGAAKSTTAKTAAKSATTKSATTRGAAAKSATTRSGTKSSTAKKVGEESAATGSSAPDDGGGAAEAASGGTRRTD
(276) Reverse gyrase [Caldicellulosiruptor saccharolyticus DSM 8903]
6
MATGAKYYHSCINCGGINSDTRNQKGLPCEKCLPFENNMNILESLKEHNSLKDYAYFWNFQNEYKEFEKFFVSKVGKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWMAKNGKKVALIFPTVSLVEQTHQRLLEFANKEPKENVKILSYKSSMKRTEKDEFEKNFENGEFDILIVSSQFISKRKDDLAKKVFSLVFVDDVDAILKSSKNIDTLLQMIGIDQKTIDKTFENLKKGVKYPEQKQNGTSSTPSKGILIVSSATAKPQGLKPLLFRELLGFEIGRFTFSVRNITNIRIAGKSKVKLLETIKILNDGILLFVENEEEGKDVTNFLENEGISVGKTWEDFEKSFEEFKDGKLKILCGIYSYYGKLVRGIDLPLRIKYSIFWGTPSFRFSTDIEKAPRFVLERVFSDYLEEHPKLKSFFKNIDKYQVERLREVVKKYIPQDRWTDFIKKSFSNLKISDEGQIFFPDVFTYIQGSGRTSRMLGSSLTKGVSILFEDDDLLFESLRSRLMFLLDEEWKTEDEVCFEDLIKEVEMSRNEALIDERSSDLKSRLMIVESPTKAETISRFLEKASTRRYGRLSVYESVTPDGILLITASKGHVYDLDTKTGVHGVEISNGNFIPYYNSIKRCTSCGTQFTDEYSSCPKCGSDKIDDKKEILKVLREIAAEVDEILVATDPDVEGEKISWDISQYLKPVNPNLRRIEMHEITKFGFESAIKNQRDFNANLVKSQIVRRIEDRWVGFELSSKLQKNFQSYNLSAGRVQSTILGWIIEREKEYAKSQKEFTFVRFENGFGFEAEGKIDGDKVLVDVVEENEKELETILPFNTPTLLSYASQKLNLSVQEIMEILQFLFEHGFITYHRTDSNRISLTGQNMARLYLEKIGKKDLFVGRSFGSEGAHEAIRPVKPISPLELKELSSERLAQGLTANHIKVYELIFNRFFTSQMKNPLVRYQKLIFRFDKQEIEKEMPIEVIEEGWLLFSPIQIFSKFESGEYQIIEKKNYKKHTTPLFTQAMLIDEMKQKNIGRPSTYAKMVEILFKRGYVFEDQYRRIRSTALGRKVYSYLAQHYQDYINEETTRDLERLMEVVEIGEKDYQSVLSSLYEELTKIMQR
(1148) DNA topoisomerase 1 [Caldicellulosiruptor saccharolyticus DSM 8903]
1
MKKLVIVESPAKARTIAKFLGKEFKVEASMGHIRDLPKSDLGVDVENNFAPKYINIRGKADVINRLKKSAQEAEKVYLATDPDREGEAISWHLAIILGLDQNDKVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIEKFKPEEYWTLEAVFKKDNQEFKAKFYGSKKGKLELKNQEQVDKIINQIKDKNFKVTKLKISEKKKNPPPPFITSTLQQEASRKLRFTPAKTMMIAQMLYEGVEIKGEGSVGLITYMRTDSTRVAEEAQEAARRIILQRFGKEYVPEKPRVYKTKKDAQDAHEAIRPTYIEKDPESIKDSLTPDQYRLYKLIYDRFLASQMESSIYDSLSAELEVEGYVFKLTGSKLKFAGFMEVYVEGKDTDEEEEENQLPEIFEGEMLKPIKLEKKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKVVTNILKEYFKDIIDIEFTAELEENLDRIEEGKADWVEIVRKFYLPLEKELETARNTMQQIKVDDEETDVVCENCGRKMVIKKGRYGRFLACPGYPECKNTKPYFDYLDVLCPKCGKKLIEKKSKKGKKYFTCESYPECNFIVWERPAKNCPKCNQLMFEKGKKRSKKLVCSNESCGYEEKIVEKGE
(1123) DNA topoisomerase [Clostridium phytofermentans ISDg]
7
MKVGKFMGKSLYISEKPSVAQEFAKALKSNFRKSDGYMESEDSIVTWCVGHLVTMSYPESYDPALKKWSLQTIPFLPKEFKYEVIPSVSKQFQVVKGLLNRSDVDKIYVCTDSGREGEYIYRLVDQMAKVPKNKEKRRVWIDSQTEEEILRGIREAKPLSDYDNLSSSAYLRAQEDYLMGINFSRVLSLKYGYTVNNFLKNEKHSAIAVGRVMTCVLGMVVRREREIREFVKTPFYRVMLTLETSDRTFDGEFKAVEGSKYYLSPLLYKENGFREKQEAEKLITMLTGYESEYETRIENNNKNSYLAKLKQDEESKQLVAEIVSMEKKKENKNPPLLFNLAELQNECSKLFKISPDETLKYTQELYEKKLVTYPRTDARVLSTAVSKEIYKNIKGLTALSQFQPFAEEVLALGSYKNIAKTRYVNDKQITDHYAIIPTGQGFGALSSLSPTAKRVYVSIVKRFLSIFYPPAVYQKIAITTKIDTESFFSSFRVLIEEGYLKVAGYQGNTNTAMQDTDGSAKTSTKTEADGKEKGSDEETEEEKDYDATFFEVIKSLKKGMKLPVRNFTIKEGETAPPKRYNSGSLILAMENAGQLIDDEELRAQIKGSGIGTSATRAEILNKLVKINYLSLNKKTQIMTPALMGELIYDVVNVSIRSLLNAELTASWEKGLTMVSDGTITKDEYIAKLEGFVGRMTEGVKGVNNANLLIPYFEQVAQNYKK
(376) DNA topoisomerase 1 [Clostridium phytofermentans ISDg]
1
MPKYLVIVESPAKAKTIKKFLGNNYEVLASNGHVRDLPKSQMGIDVENGFEPKYITIRGKGDLLAKLRKEVKKADKVYLATDPDREGEAISWHLSQTLKLDDKSASRITFNEITKNAIKNSIKEARDIDMNLVDSQQARRMLDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREEEINDFVPKEYWNLDASFKVKGEKKSLVAKFYGDTKKKISIESKEEMDKILADLKGAQFKITEVKRGERQKKSPLPFTTSTLQQEAAKLLNFSTQKTMRIAQQLYEGVDVKGHGTIGLISYLRTDSIRVSEEADTAAREFIKTQYKPEYVNSQDVNKTTGKKIQDAHEAIRPTYVDLTPVIVKESLSREQFRLYQLIWKRFIASRMQPAKYETSTAKIDGNGYRFTVASSKLIFDGFMAVYASEDEEEENTTSNMMSLSEETQLTFEEFNSSQHFTQAPPHYTEAALVKTLEELGIGRPSTYAPTITTIIARRYVIKENKNLYVTELGEAVNRIMKQAFPTIVDVNFTVNLEALLDGVEDGVVNWKTVVSNFYPDLESAVQDAEKQLEQITIEDEKTDVICSECGRNMVIKYGPHGKFLACPGFPDCRNTKPYFEKIGVACPLCGSDIIIKKTKKGRRFYGCENNPECEFMSWQKPSGKLCPICNGIMVEKGQKLVCVNEGCGHVENKEQN
(321) DNA topoisomerase 1 [Methylocella silvestris BL2]
1
MYVVIVESPAKAKSINKYLGKGYEVYPSYGHVRDLPAKDGSVDPDADFAMLWDVDVKSAKRLNEIARAVKDADKIILATDPDREGEAISWHVLEVLKAKKVLKDKPVERVVFNAITKSAVLEAMQHPRQIDVALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEAFVAREYWSIVAHLRTQADAPFTARLVGADGKKITRLDVGTGAEAAAFKTDLENATFRVAEIEAKPAKRHPSAPFTTSTLQQEASRKLGFAPARTMQLAQRLYEGADIDGETVGLITYMRTDGVDLAPEAITSARSVIARQFGDAYVPKAPRKYTVKAKNAQEAHEAIRPTDLARLPRAVARALEPDQAKLYELIWTRTIASQMESAELERTTVDIEALAGARKLDLRATGQVVRFDGFLKLYQEGRDDEDDDESARLPDMAKDERLKRERIEADQHFTEPPPRFTEATLVKRMEELGIGRPSTYASTLAVLRERDYVRIEKKRLHPEDKGRLVTAFLEAFFARYVGYDFTADLEEKLDRVSNHEIDWKQVLRDFWLDFSGALAGTKDLRTTEVLDRLNEILGPHIFPPKEDGSDPRGCPSCGEGKLSLKLGKFGAFIGCSNYPECKFTRTLAAPDGAEANGGERPGVKSLGVDPDSGEEITLRDGRFGVYVQQGEGEKPKRSSLPPTIAPADLTLEQAIALLSLPREVARHPESKEPIVAGIGRYGPYVQHGKTYANVAKDEDIISIGANRAIDLIVAKESGLTGRRFGASESAPARVLGEHPAGGAVSVKAGRYGPYVTHGKINATLPKEADPTTLTLEGAVALLAAKASGGGAPMQGRLLGDHPSGGPITVRAGRFGAYVNHGKTNATLKRDASAETITLEEAIRLIEDKEAAGGGPRKAAAPKKAAKSSAAAKKAAPNAKNKTAPANDEDPPFEPSPNRKPAAKAAAAAHKKPAAKAAAAKLKQAKQA
(888) DNA topoisomerase 1 [Actinosynnema mirum DSM 43827]
8
MAGSTRTRKSTGGSAGGNRRLVIVESPTKARKIASYLGNGFVVESSKGHIRDLPRGAADVPAKYKGQPWARLGVDVDHDFEPLYIVTPDKKSTVAELKELLKGVDELYLATDGDREGEAIAWHLLETLKPSVPVRRMVFHEITEPAILAAAASPRDLDLSLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERERMKFVTASFWDVSATIDAGAEATPRQFAGRLVSVDGTRLATGRDFGSDGRLKDGVEVKVLDEAHARAIAEGLTGAAMRVASVEEKPYTRKPYPPFMTSTIQQEAGRKLRFSADRTMRAAQKLYENGYITYMRTDSTALSETAITAARAQATDLYGAQYVAKEPRQYTRKVKNAQEAHEAIRPAGEVFRTPGQVARELDSDEYKLYELIWQRTIASQMADARGNTTSVRVAGRTGGGEDVLFASSGRTITFAGFLKAYVETVDSEAGGNADDAESRLPQLVAEQPVSAAELSADGHSTSPPPRFTEPSLIKTMEDLGIGRPSTYASIISTIQDRGYVWKKGSALVPSWVAFAVVGLLEQHFGRLVDYDFTAALEDELDGIAEGRQERTTWLSGFYFGGDVGPESSIGRSGGLKKLVGSSVEEIDAREINSIPLFSDEGGHTVVVRVGRYGPYLEREVDGASQRANLPDDLPPDELSLEIAEKLFATPQEGRSLGNDPATGHEIVAKEGRFGPYVTEVLPEPAEGKKAGKPRTSSLFKSMSLDTVTLEDALRLLSLPRVVGADPESGAEITAQNGRYGPYLKRGTDSRSLTSEDQLFTVTLDEALKIYAEPKKRGRAAAAPPLKELGNDPVSGKPMVVKEGRFGPYVTDGETNASLRKSDNVETLSDERGSELLAEKRAKGPSTKKKPAARTTKAAAKPAAKKPAAKKTPAKSKG
(830) DNA topoisomerase 1 [Stackebrandtia nassauensis DSM 44728]
8
MAQTTKRLVIVESPAKARTIAGYLGDGYMVDSSLGHIRDLPRNAKEVPPKYAKEPWSRLGVDVDNDFAPLYVVNPDRKAHVKTLKDQLAEADELLLATDEDREGEAIAWHLLETLKPKVPVKRMVFHEITKSAITQAVNNPREINRSLVDAQEARRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRIVVERERARMRFVTADYWGITAQLRTKDGADFAANLLSFDGDRVATGKDFDAETGRPKAGVVHLDEAGARGLAARLANVPYTVGKVDNKPYRRRPYPPFMTSTLQQEASRKLRQSSAQTMRLAQRLYENGYITYMRTDSTNLSETALTAARRQAAQLYGERFVPAEPRRYARKVKNAQEAHEAIRPSGDSFRTPSELASELSTEELRVYELIWRRTIASQMTDAVGNSVSVRINVTSATGEDCEFSASGKTITDPGFLKAYVESRDEGEADDAERRLPELERGQALTADSLEPAGHRTQPPARYTEASLVKALEERGIGRPSTYASIMQTIQDRGYVFKRGQALIPAFLAFAVVGLLEKHFARLVDYDFTAGMESELDDIAAGEGRSLEFLRSFYFGGNNAADGTVAASGGLKKLVAEELGRIDARGVNSIPLFTDEQERRVVARVGRYGPYLERFAPTAEPGEPGERVSIPDSLAPDELTQAKAEELYEVGSGERELGEHPETGEIVYAKSGRYGPYVTSGEKSASLLSDMKLKDITLDDAVRLLTLPRLVGVDADGEEVRAGLGPHGPYVVKKRDYRSLETEEQLFTVTLEQAQALLAQPKKRGRQAARPPLKELGTDPATKLTVVIKDGRFGPYATDGETNASLKKTDTIEDITIDRASELLAERRAKAPVAKKAAKKAAKKTTAKKTAKKTVKKAAKKTAKKTTTTKKAAKKSAAKKKTGNPREDA
(1865) DNA topoisomerase 1 [Brachybacterium faecium DSM 4810]
8
MTGGRHLVIVESPAKARTIGRYLGEEYDVKASVGHIRDIPVPRDLPAEMKKGPYGKFGVDVENGFDPYYIVSPDKKKTVAELKKALKDADTLYLATDEDREGEAIAWHLLETLKPKKSLPVKRMVFHEITKDAIRAALENTRDIDASLVDAQETRRILDRLVGFELSPVLWRKIKPSLSAGRVQSVATRLVVERERERMAFVAADYWDITGTFAAEGGADGTQFTAKIATVDGARVATGSDFADDGTLKPRAKNAAVLTAESTQTLVEVLGDAPATVTALESKPYTRRPAAPFTTSSLQQEASRKLRLGARQAMRVAQSLYENGYITYMRTDSVTLSGEAIRASRAQAAELYGSQFVPDKPRYYQNKSQAAQEAHEAIRPAGDHFRTPAEVAGQLSGDEFRLYELIWKRTIASQMADAKGTTSTVELLLENEGRAATFRAAGTVITFRGFLAAYEEGRDASRYKDDEEKGGDKRLPQMEEGQTLDTRALTPDGHTTTPPPRYTEASLVRALEDRGIGRPSTYASTVATVQDRGYVLRRGTALVPSWTAFAVVRLLEEHFGPFIDYDFTAQMEQQLDRMAQGDLARSEYLKNFYLSDGTDGPIGLKPMVDDLGEIDARAINSIEIGEGITLRVGRYGAYVEQFPRDEDGELIEGADPRRANVSDEVAPDELTVEKAKEMLERAKDDGRVLGTDPETGHEIVAKDGRYGPYVTEVLPEAQTADGKKVPKSKQPKPRTGSLLKSMDLSTVTLEDALKLLSLPRVVGTAADGTEITAQNGRYGPYMKKGTDSRSLETEEQIFSITLEEAEKIYAQPKTRGRAAAKPPLKELGTDPTSEKPIVIKDGRFGPYITDGTTNVSLRATEKVEEITEKVAIEKLAEKRAKGPAKKKAPAKRTTTRKKSTTTKK
(1192) DNA topoisomerase 1 [Dyadobacter fermentans DSM 18053]
1
MSKNLVIVESPAKAKTIESYLGQDFTVKSSFGHVRDLPEHDMGVDVEHGFQPSYEISSDKVKVISELKKLAKDAEVWLATDDDREGEAISWHLKEALGLPDNTKRIVFREITKTALRNAIEKPRTIDTALVDAQQARRILDRLVGYELSPVLWKKIRIGKSNLSAGRVQSVAVRIIVEREREIDAFKSKSSFRVTAHFDLGNGKVLNAELAKNIPTEQEAQQFLEKCVGAEFSIRNLEVKPAKKSPAPPFTTSTLQQEASRKLSFSVAQTMTVAQRLYEAGKISYMRTDSTNLSEEALDKSKQQITKEYGIDYYNRRIFKTKSESAQEAHEAIRPTDFSTLLGSSDRNEQRLYELIWKRAIASQMSDAQLERTTATIGISTTSEELVAQGEVIKFEGFLKVYLESSDDEGDEEQKGMLPPLNIGQILKLADMKATERFTRNPPRYTEASLVKKLEEMGIGRPSTYAPTISTILKREYIVKEDRQGFEREFKEITLANEQIKSKVNKEVYGSEKAKLFPTSTGMVVNDFLVSHFQDIVDYSFTASVEKDFDHIADGQLEWQQMIKNFYTPFQKKVAEAREEAIDKSLTSRELGEDPATGKKVSVRIGKYGPYVQIGDVEDEEKPRFASLQKGQLMETITLDEAFELFKLPRQVGFFEDKDMIVNVGKFGPYVKHDGKYYSLAKTDDPMAVTEDRLVEIIEEKRLQDSNRTIKEFAEDPEAKVLNGRYGPYIAFGKKNVKIPKGTEPASLTYEQVLKLAAETPDKPAGRGGARKPAAAKAPAAKKPAAKKAAKK
(678) DNA topoisomerase III [Dyadobacter fermentans DSM 18053]
7
MKVCIAEKPSVAKDIAAVIGAGQRRDGYYEGNGYQVTWTFGHFCTLKEPHDYTERWKSWRLEELPMIPSSFGIKLIDNEGAMRQFGVIETLVRNCEEVINCGDAGQEGELIQRWVLLKAKCNVPVKRLWISSLTEQAIREGFEKLREASQYDNLYAAGSARAIGDWLLGMNATRLFTKKFGGGKAVLSIGRVQTPTLALIVQRQKEIDAFVSEEYWELKTIYRETEFTATIDRIKNVEKANKGLAYLQQHDFEVTAFEKKEGKEGNPRLFDLTSLQVEANKKYGYSAEDTLKHIQNLYEKKFVTYPRVDTTYLSEDLHPKVEGILRELTYYSQFTAPLLANLPIPKSKNVFDDKKVTDHHAIIPTGVLPAHISQDEKRIYDLIARRFIAVFYPECRVSNTTVLGVVGQVEFKATGKQILEPGWRELYANDNASKKEAEEEKVMPIFEVGERGPHEPRVHQGKTSPPKAYTEATLLRAMETAGKQVEDEEMRELMKDSGIGRPSTRANIIETLFKRKYIEKKKKNVFATQTGIDLIDTIQNELLKSAELTGHWERKLRQIEKGEYAMDTFKQELIDMVVKLTHEVKNERARSITIVEEAPVAEKEEKPKKERKPREPKEDIAIETLNCPKCREHLLKKGKTAYGCSNFQACGFKIPFEFLGKKLTDKHIFDLLSKGKTVKIKGLQIPGSPDPIDARLVMNGDFNFEVG
(278) DNA topoisomerase 1 [Beutenbergia cavernae DSM 12333]
8
MPSSARKLVIVESPTKARTITPFLGDDYDVEASVGHIRDLPQPSELPAEMKKGPYRKFAVDVENGFDPYYVVDADKKKKVSELRKKLKAADELYLATDEDREGEAIAWHLLEVLEPKVPVKRMVFHEITREAIQRALEATRDLDTRLVDAQETRRILDRLYGYEVSPVLWRKIGPGLSAGRVQSVATRLVVERERERMAFRSANYWDVRGEFSGGRGETAGTSFSARLTALDGDRVATGRDFDDSGSLTSRAVHLDEAAATALVSALDGVDVVVRSVDTKPYTRRPAAPFTTSTLQQEASRKLRMNSRATMRTAQSLYENGYITYMRTDSVTLSTQAITAARRQAAELYGAEYVPDAPRLYANKSKNAQEAHEAIRPAGDSFRTPAQVASRLSGDEFRLYELIWKRTVASQMADAKGSTASVKLGASAAYPDGATRDAEFSASGTVITFRGFLAAYEEGRDAGRYDEDGDGAGRGSSSGSSAARETRLPDLAQGDQVAAESLTAEGHDTSPPPRYTEASLTAALEERGIGRPSTFAATISVIVDRGYVLRRGQALVPSWLAFSVVRLLEDHFGRLVDYDFTAAMESDLDRIARGEQDRVAWLTRFYFGDEAAGSEGLQQLVSELGDIDARGINSIDLGGGVTVRVGRYGPYLEATGPDGEPQRASVPDDVAPDELTLERARELLATQGEGDRELGTDPATGRTIVARSGRYGPYVTEVIPDDAPAASDDAKPAKRKPAKPKPRTASLLQSMQLEAVDLEQALKLLSLPRVVGVDPESGDEITAQNGRYGPYLKKGTDSRSLETEDQIFDITLEQALAIYAQPKQRRGQRASSALRELGDDPVSGKPVSVKDGRFGPYVTDGTTNATLRKDDEVESITPERAFELLAEKRAKGPAKKRTTARSSSRKAPAKSRS
(1284) DNA topoisomerase 1 [Jonesia denitrificans DSM 20603]
8
MSQGRKLVIVESPAKARTISAYLGADFDVEASVGHIRDLPQPSELPAEMKKSGYGKFAVDVDNGFAPYYEVYPDKKKKVTELRRLLKDADELYLATDEDREGEAIAWHLLEALKPKVPVKRMVFHEITREAIQRALTTTRDLDERLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVPASYWDVTAQFEATQGQDAGGTFQARLTHVDGTRVATGRDFTDRGELKARDVVHLTEDAATTLAQSLTDAPATVASLDTKPYTRRPAAPFTTSTLQQEASRKLRMSSKTAMRVAQTLYENGYITYMRTDSPALSAQAISAARSQAADLYGTEFVPEKPRHYASKSKGAQEAHEAIRPAGDTFRTPAQVANVLSGDQFRLYELIWKRTVASQMADARGSTASVRIDVPGQVDGQTTTATFSASGTVITFRGFLAAYEEGRDVDRYDDGSQSDGRLPHMVEGDPLASRDVSADGHTTTPPPRFTEASLVKALEERGIGRPSTYASTISTIQDRGYVNNRGQALVPSWLAFSVIRLLEEHFSQLIDYDFTAQMESDLDEIAAGQGDRVNWLTQFYFGGAGGDKAGLKELVEGLGDIDAREINTVSLGEGIVLRVGRYGPYIEHLTADTAEGENPPRASVPDDIAPDELTLDVARDLLENQKDGDIELGSDPVSGHMIVAKSGRFGPYVTEIIPEPELDESMSAAAKKKAKAALPKPRTASLFKSHSLTTITLDEALQLLSLPRVVGVDPDTGTEITANNGRYGPYLKKGTDSRTITSEEQLLTITLDEALEIYKQPKRGRGATASAPLRELGVDPTSEKPIVIKDGRFGPYVTDGKTNRTLPKDATVESVTFEQAVELLAEKRAKAPVKRATRTTAKKSTATKKTTTTAAKKTPAKKTTATKKTQS
(870) DNA topoisomerase 1 [Kribbella flavida DSM 17836]
8
MAGATGTKSAAGAPAAAAGRRLVIVESPKKARMIAGFLGSGYVVESSFGHIRDLPKGADEIPAKYKGLPWARLGVNIDDHFDPLYVVPADKKAQIRKLKDLLKDADELYLATDEDREGEAIAWHLLDELKPKVPVKRMVFHEITPKAIQDAVGSARQINDALVDAQEARRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVAIRMVVDRERERIAFRSASYWDLDATLDAGEGKTPRLFPSRLVSVDSRRVAQGRDFAPTGELKSQNTVHLDEPTATALAAALAESRFTVRSIESKPYTRKPYAPFRTTTLQQEAGRKLGMSASQTMQIAQRLYENGNITYMRTDSVTLSDTAITAARAQVRELYGASYLPDKPRVYTSKVKNAQEAHEAIRPAGEVFQTPAQTGLSGPEYRLYELIWMRTIASQMKDAAGNSVSIKIDATASTGENCEFTSSGRVITFHGFLKAYVEGADDPSHETDDRETQIPDVAEGDVLPATEVLASGHETKPPSRFTEATLIAQLEEREIGRPSTYASILGTIQARGYVYKKGNALVPAWLAFAVVRLLEQHFTRLVDYAFTASMEDVLDDVAAGNLQREGVLGRFYFGDDDLEGLQSMVSDLGDIDAREMSTFGVGPPDSGIVVRVGRYGPYVEGPDETRANVPEDLPPDELTVDKAKELLSQPSGVEVELGTTPDTGLKVIAKAGRYGPYVTEVLPEGAPKSAKPRTGSLLKSMSLDTVTLDDALKLLSLPRVVGKDPESGDEITAQNGRYGPYLKKGTDSRSLQSEEQMFDITLDEALKIYAEPKQRGRRAAAPPLKELGEDPESGKPVVVKEGRFGPYVTDGETNATLRKDDSVDTISLLRAAELLADKRARGPVKKTAKKAPAKKTAAKKTTAKKATAKKTAATGATKKTAAKKTTKKAAAKKS
(1387) DNA topoisomerase type IA central domain protein [Pedobacter heparinus DSM 2366]
7
MKIVIAEKPSVGRELAKVFGATTKKDGYIEGKGYSFTWAFGHLLQLAPPQEYGFIGWRRQHLPMLPKKFKLAIRKIKTKDGMVEDPGVRKQLDIIKKLFDEATEIIVATDAGREGELIFRYIYYFLKCKKPFRRLWISSQTDEAIKEGFRNLKPGTDYDTLFNSAHCRSESDWLVGMNATQALSISAGNRSVLSLGRVQTPTLAMICSRFLEIKNFVPQTYYQLAIQLDKDGQLFRAMSVSNFDKKEEAEELLAKIEDVASGFSNGGKILSVEAKPRKEPPPLLHDLSSLQQEANKRKGFTADQTLSLLQGLYESKLVTYPRTGSRYIGDDIFAGVPALIDKVRGHKDFGKQAEFLLTVPLNKRSVNAKKVTDHHAILPTGESPYQLNGDKQAVYDMVVGRMIEAFHQECVKEITKISVESGSLFIANGTVIRAAGWRSVFNESDEEKKDEDNPALPKLKKGEELPVTNKALLEKQTKPKAMYNEASLLKALETSGKDIEDEELRYAMKDSGLGTPATRAAIIETLISREYVSREKRNLVPTTKGLAVYDVVKDQKIAQAELTGQWEKRLEEIRSGASVSDFKAEIADYTKTITNELLAAGLTLAEKI
(2) DNA topoisomerase 1 [Pedobacter heparinus DSM 2366]
1
MAKNLLIVESPAKAKTIEGYLGKDFLVKSSYGHIRDLVKGDMAIDTANNFAQTYEVPSDKKQVVAELKKLAKDAEMVWLASDEDREGEAISWHLYETLGLKENKTKRIVFHEITKPAILKAIETPRSIDYNLVNAQQARRVLDRLVGFELSPVLWKKIKPSLSAGRVQSVAVRLIVDREREVNKFNAAAAFKITAEFVTGNGKELVKAELPQRFEKEADAEKFLNDCAGAGFSVDSLETKPAKRNPAAPFTTSTLQQEASRKLGYSVSRTMQIAQRLYESGRITYMRTDSVNLSETALQAAASEIRSAWGDKYHQPRTYKTKSAGAQEAHEAIRPTYFNQHTVPGDSSEQRLYELIWKRAIASQMSEALFEKTTAQIGISTRKEQLIAEGEVLKFDGFLKVYLESSDEEDAEDSEGNNMLPALSRGQALTLKVMNATERFSRPPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVVKEDRDGRQRSFAAIELSNGSVTKKTKTEITGAEKGKLFPTDIGEVVNDFLVEHFKGIVDFNFTANVEKEFDEIAQGLQEWTKMLHSFYTPFHLEVENTLETADRANGERLLGLDPATGKNVYTKVGRFGPLVQIGENDDEEKPRYASLSKSQSVGTVTLEEALEQFKLPFSLEDYQGKEVSVGVGRFGPYVKWGDAFISVPKNEDPLSIDQARAIEIIGEKITADAPVAHYQGMPVTKGTGRFGPFIKWNDLFINVPKAYNFDRLSQQDIEELIGKKIEKEANRFIQQWPAEKIAIENGRWGPFIRFGKEMLKLRKNPATNDKYTPEELASIALDEVKKLIVEQVPNAFEPKKKAAAKKTGAAKKAPAKKKAVAKK
(1399) DNA topoisomerase 1 [Desulfotomaculum acetoxidans DSM 771]
1
MSTTLVIVESPAKAKSIGKFLGKKYTVKASMGHVRDLPKSQFGVDVEAGFMPKYITIRGKGDTIKELRSAVKKADTVLLASDPDREGEAIAWHLQKLLKIEDNQPCRIEFNEITKQAIQNAVTHPRKIDYNRVNAQQARRILDRLVGYNLSPLLWRKVRKGLSAGRVQSVAVRLICEREEEIDSFEQVEYWTLTGKFLKAKAGFEGKLLKYRGEKLEVSDEESMQKILQALEGSSYVIEKVSRRERSRRPAAPFTTSSMQQEAYRKLNFTARKTMVVAQQLYEGLDLGKEGSTGLVTYIRTDSTRVSGTAKEEAKEYIDKQFGQAYTGEQDGEIKGQKERKIQDAHEAIRPTSVFREPDQVKKFLTPEQYKLYRLIWSRFVASQMSPAIIDTTSVDIAAGEYTFRSAGSIVKFSGFMKVYTEGNDDGQKEEIKTLPELAEGEKLELTELLPKQHFTQPPPRYTDASLIKLLEENGIGRPSTYAPIVETIQKRGYVSRENKQFFPTELGFVVVEMLKEHFPEIIDVEFTADMEKKLDHIEEGDTDWIKILEEFYGPFHETMEKAEEAIGKIELQDEVTEEICELCGRNMVIKFGRFGKFLACPGFPDCRNTKPLLEPTGVTCPLCSGEVVLRRTKKGRKFYGCSRYPECDFVTWDLPTNEKCPSCNSMMVKKSSKNKQMLSCVNQECKLKIEMSEDKK
(48) DNA topoisomerase [Desulfotomaculum acetoxidans DSM 771]
7
MKQLVLAEKPSVARDLSNVLGNFNKGNGYLESDAYIITWAIGHLVTLAEPDDYDAALKKWFLNTLPILPREFKLKPVSATLKQFNIVKSLLHRNDVGDIICATDSGREGELIFRYIYKLTDCQKPFKRLWLSETTPAAVRKGFDNLRPGNDLDRLAFAAEARSQADWLIGINATRAFTVKHNQLLSVGRVQTPTLALIVNREQEIRAFVPEKYWELFALFTKENGQTYIGKWFKKEKKAVENWEIPIQVGQKQTNQNPAASFEAAQGGIPSVMGEAVPSSNGQDKPVAMQTKFAAREAARDIQKKVTGQPGQVVSVEKKDIIEHPPLLFNLNDLQKEANKKFGLSAAKTLSVAQELYESRKLITYPRTDSRCITVEMGKTIPQRLGALAVVAEYENFIHLIKERKAFLNKRYINDSKVTDHTALIPTNVKPDLDKLSSDERRVYDLVVRRFLAAFFPPARYEQTQVITEVKQETFLSRGRVELDKGWKTVYDPVQDKLVDDEQGILPVIENEESVLTTKTDIKEKKTNPPKRYTEAALLSVMEGAGRLLNDEELKEAMRGSGLGTPATRAAIIERLLKVGYIERRKKTLLPTEKGENLIKLVPEQVKSPEMTARWEKALADIEDGQLNPGEFMSGIIEQTRQVVELARRQKTEGEPLRNNRDIIGKCPLCGRPVVEYPKSYSCSDYRAGCQFVIWKVILGKNITVEMARILLEKGRLEKQPGFISKNGKKFDAPLIIRNGRVEFDF
(1746) DNA topoisomerase 3 [Desulfotomaculum acetoxidans DSM 771]
2
MKSLVLAEKPSVAREIARILNCTIKGKGYLEGNKYIVTWALGHLVTLAEPEDYDEKYKTWRTEDLPMLPAEMKTVVIKKTGPQFHIVSKLMKRPDVRELIIATDAGREGELVARWIMKQARCQKPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAICRAEADWLIGLNVTRALTVKYNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANLGKFQAEWRDKSGKHNRFSDCLQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLTELQRDANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGYFAELVKPLTAKPLPINKRLVDNSKVTDHHAIIPTTERANLAALTAEEKNIYDLIVRRFIAVFYPAYSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNLPPLKKGDKVKVLSCKSVKGQTKPPARYTEASLLSAMEHPGKFIEDEILKESVKESGLGTPATRAEIIEKIISSNYVERRGKELIPTAKGIQLVELVPPELKQADLTAKWEQQLHDIAMGKSKRTKFISGIREHAEKIVTTVLNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRGSNLVCPDRSCGHRQVEKETSNRPCPQCKKRRMEIREGKGGKIIVCTHCRYQEKYVLQPKREAKVNIKAYSDSAPLVTNLSILANFKFNGAKEKSD
(903) DNA topoisomerase 1 [Eubacterium eligens ATCC 27750]
1
MHKYLVIVESPAKVKTISKFLGANYKVMASQGHVRDLPKSQMGVDIEHDYEPKYITIRGKGDILAALRKEAKKADKVYLATDPDREGEAISWHLAAALKLEDKDIYRITFNEITKNAVKASLKEARKIDMNLVDAQQARRVLDRVVGYGISPLLWAKIKRGLSAGRVQSVALRMICDRENEIDEFIPEEYWSMEAVLNIKGEKKPLIAKFYGDENGKIEIKNGAQMQDILDEVKKSDFSIESIKRGEKVKKSPLPFTTSTLQQEAAKTLNMSTKRTMNIAQQLYEGVDIKGRGTVGLITYLRTDSTRVADEAKVSSREYISQNYGEKYIPQEANAKKDDKKIQDAHEAIRPTDLNLSPAIVKESLQRDQFRLYQLIWKRFVASQMAPAVYETTSVKIMAGKYRFSVAASKVMFDGFMSVYKNDDDNEENNTLAKGLDENSELSLEDVNGVQHFTQPPAHFTEASLVKALEEQGIGRPSTYAPTISTIIARHYVIKENKNLYISELGNAVNNIMITAFPTIVDVKFTANMESLLDGVAEGTVEWKEIIRNFYPDLKVAIDEAEKELEHVKIEDEVTDVICDKCGRNMVIKYGPHGKFLGCPGFPECHNTKPYLEKIGVPCPKCGKDVIIKKTKKGRTFYGCDGYPDCDFVSWQRPSEKKCPKCGGYMVEKGNKIVCADETCGYVENKNDKEQ
(391) DNA topoisomerase [Eubacterium eligens ATCC 27750]
7
MLQENNNCVIDTEMRDIMGKSVYIAEKPSVAQEFAKALHVNFTRKDGYLEGGDHIVTWCVGHLVTMSYPDAYDPNLKRWSFDTLPFIPKEFKYEVIPAVAKQFNIVKDILTRNDVEYIYVCTDSGREGEYIYRLVRQEAGVKGKKERRVWIDSQTEEEILKGINTAKDISEYDNLSDSAYLRAKEDYLMGINFSRVLTLKYGRNIANYLHLDRAVVSVGRVMTCVLGMVVRREREIRSFVKTPFYRVIGQAQVENSTFDAEWRVSDKSMYAGTPYLYKDNGFKDREKAEELVKFLSDPLPAQGVVDSIERKKETKNPPLLYNLAEIQNECSKLFKISPDETLNIIQELYEKKLVTYPRTDARVLSTAVSKEIHKNIGGLRNFPPVKEIAEHILQNNMQKGIEKTRYCNDKAITDHYAIIPTGQGFNNLKNLSVTAARTYEIIVRRFLSIFYPPAIYQKVSIISDVKNEKLYASFKVLVDEGYLSVAKNSFAKARNDAKVKDDDSVDNKEDNKCDVALFEVLKKYRKGSTITFNGFNIKEGETSPPKRYNSGSIILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLNTIKYISINSKTQIITPTFLGEIIYDVVDNSIRHLLNPELTASWEKGLTGVAEGNITADEYMEKLDGFVSRRTRAVMALRNQVGLVGLFNETAKNYK
(1254) DNA topoisomerase 1 [Anaerococcus prevotii DSM 20548]
1
MAKNLVIVESPTKARSISKMLGRNYKVMATVGHLRDLPKSKFGVDIENNFEPEYIKVRGRAKTINELKKEAKKAENVYLATDPDREGEAISWHLQFLLDLDPEAKNRVEFHEITKENVKNAIKNPRKIDQNLVDAQQARRVMDRIVGYEISPILWKRVKAGLSAGRVQSVALKLIVDKQKEIDDFVPEEYWTITAHHKEGREKFDSEFYGQINKKIKISNENGADKVLNKIDKDKFEVVKITKTKKRRKPQKPYTTSTLQQDASNRLGFSTRFTMQLAQQLFEGIDVGDGSVGLITYMRTDANRISKEIVGEALSYIKEKYGPEYAGKGNTYGGKKKGSQDAHEAIRPTSIRRNPLEIKEYLTDQQYKLYKMIWERVVASQMTDYEFLSTQVLFDNNSLIFKTNGKITLFEGFNKLGANKENENILPELKEGDVISAESIDKDQHFTKPPARYTEASLVKTLEEFGIGRPSTYSATINQIISRNYVELEGRSIFPTDLGKTVNTFLQENFDDVINVEFTREMEDALDNIAEGDRFWKETLKSFYKDFEKDMKGVKKDGKDYKVRDEILEEKCPKCGKPLAIKHGRNGKFIGCTGFPDCNFTKSIVKSTGVKCPECEDGTIIEKVSKRGKRFYGCDNYPKCDFALWDPPTGEKCPECGSLLIHKKNRSTDEIKCSSCDYVKEKRR
(894) DNA topoisomerase 1 [Brachyspira murdochii DSM 12563]
1
MSDTTTEAKVKKTAGRKSKKESKKKKLVIVESPAKAKTINRYLGSDYLVMSSMGHLIDLPRSRLAIDVDHGFEPEYITIRGRAKILNDLKKEAKKAEEVLLAADDDREGESIAWHIGNKIRGVNSAVPIKRIVFHEITKDALKEAIDQPRDIDISKVNAQKARRVLDRLIGYNLSPLLWEKIKRGLSAGRVQNVALLIICNREDEIETFVPVEYWTFGVFLKHKNKEFLADLQKYKGEKPDLKTKQDVEDIMEHLKDKTYTVSSIEVKDRLRNPTAPYTTSKLQQAASSALGYSASKTMQVAQSLYEGVDIAGEATGLITYMRTDSVRISPVAQEQAREFIGKEYGSNYLPAEPPAYSVKKNAQDAHEAIRPTNVFLTPDSIKEYLKTDQYKLYKLIWERFVSSQMLPAKMKNTRAIITAGDCEFSLSSSKIEFDGFMKVLTIDKEDKEKASKMPNLSKDDVCEFVENNPQQHFTTPPPRYTDASLVKILEESGIGRPSTYAPTIKTIISRHYVQRKGKQLVPTELGKLVNELISENFPELVNINFTADMESKLDKIEDDNIEWNNILKEFYPHFLDTLKTATENINNMKDFFNEETDFICEKCGKKMIKRLGRYGYFIACSGFPECKNTKGISFGICPKCGGDITLKRSKRGREFYGCSNYPKCDFVSWDKPLQEPCPKCGGLMVEKNIKNKGLFKVCIKEDCGYSEEIKEDEE
(800) DNA topoisomerase 1 [Sebaldella termitidis ATCC 33386]
1
MAKKLVIVESPSKAKTIEKILGKGYEVEASYGHVIDLPKTKIGVDIENKFEPHYQVIKGKGDILKKLKDKAKKADAVYLASDKDREGEAIAWHISNYIKVPAKTKRIEFNEITKSAINNAIKHPRNIDENLVNAQQARRILDRIVGYKISPLLWKIINKNASAGRVQSVALKLICDLEDEIREFIPQKYWEVTAITDKGIELGIYEIAGKKVDRIFDEKVMKKLKKDLAKKNLEVFKIKVTKKTQRPPLVFKTSTLQQLASSYLGFATSKTMRVAQQLYEGLSINGENVGLITYMRTDSTRISNESMADAGKYIEKNFGKEYVGKYMPAKAKGNVQDAHEGIRPTDINLSPDSIKDSLSAEQYKLYKLIWERFLVSQFSAMKYDQMQINAKNGDYVFRGTINKVTFDGYYKVFKDEDEIKTADFPEIKEGDELVVKELNIKDGMTKPPARFSESSLVKKLEAEGIGRPSTYASIIETLKTRNYAELVDKRFIPTVLGYEVKSELEKHFEKIMNIKFTANMEEELDEIENGSIKWEELMANFYKGLEVDLTKFEKEIQDLQDRRIEADIMCANGTEAMILKTGRFGKYLICESNPDEKVSLKGIQIPKEELEAGKIIVKDKVAEKESEKKGVPTDHFTKDGARIFVKKGRYGEYLESEDYENDEIRMPLPYKIKQEIKKGTAKMQDGMYIIHEELEKMLAEDQRIIEEAGLCEKCGRPFEIKIGRFGRFLACTGYPDCKNIKKIPKK
(145) DNA topoisomerase 1 [Ilyobacter polytropus DSM 2926]
1
MAKKNLVIVESPAKAKTIEKILGKNYEVTASFGHIRDLPKSKIGVDIENNFEPSYSTIKGKGEITKALRALAKKSNKIYLASDPDREGEAIAWHIAHILKLDEGESNRIEFNEITKTAIKDAVKNPRKIDIDRVNAQQARRILDRLVGYKISPLLWKIISSNTSAGRVQSVALKLICDLEDSIKKFVPEVYWEVSGDFTGGINLNLNKIDNKKVDKIKDEEIIKQLKKEIPGKSFEVTSAKISDRSKKPPLPLKTSTLQQLASSYLGFSASKTMRVAQTLYEGLNIDGNQKGLITYMRTDSTRISDEAKESAKVFIEEKYGKEYVGNYTEKKGKGKIQDAHEAVRPTDVLLEPLKIEKHLNTDQFKLYRLIWERFIISQLAPVKFKQFELLTNYDKYQFRGVANKIIFDGYYKVFKGEDAIESVKFPSIKQGDALVLEKLGVKEGITKAPARLTESSLVKKLESEGIGRPSTYASIIETLKKREYVVSEGKSFVPTSLGYEVKENLQENFPHILNVKFTAGMEEKLDRIEEGELDWKETLKEFYDDLSKYLTVFEKKVEEMENRIIVSDVLCPCGKGKMLMKSGRFGRYLKCEDEECKEKFSLKGIDIPKEQIEKGEIIVNEIVQEREKLKRGKPTDVYTDKGANLFLKAGRFGSYLESENFAEDEIRTPLPSEVRKMLAENRVIEKDGVVQLNSILKKIEEEEAELIRKAGPCEKCGSPFEVKRGRWGKFLACTGYPECKNIRKLPNDKKKEANKKK
(1578) DNA topoisomerase 1 [Aminobacterium colombiense DSM 12261]
1
MTKKESGKTLVVVESPTKAKTLSKILGSKYTVKASIGHIKDLPKSRIAIDVENNFQPEYILVKGKAKIKNELVKLARGSQKILLASDPDREGEAIAWHLCNILDVDPQTLCRIRFYEVTPKAVKEALKKLEPVDMNRVNAQQARRVLDRLVGYTLSPLLWKKIRYGLSAGRVQSVALNLICEREREIISFVPSEYWHISVLASSLDKTRNYDLKVMSFKNKSFWKEGKPLLISSSEQAEKIASDIAKQELVVKEYKVKEGKRAPLPPFKTSTLQQEAARRLGFSPRRTMRIAQSLFEGVSVPGRGPVGLITYMRTDSLRIAPDAINGARTFISERYEAKYLPAKPNFFASKARSQDAHEAIRPTDVTLTPEILKNVLNSEQHRLYTLIWNRFVASQMASALVANAILDVAAGSYGLRQTGESLIFDGWGAVWPLELKGGQLDPAQPEETLLCQEIEKEQRFTKPAARYSEATLIKTLEEKGVGRPSTYATIVETLYDRGYVEKNEEKRIEPTQLGMTVDDFLLQYFDSKSQSPIVDTGFTAQMEEQLDLIEEDQLQWVEVVRSFWNGFTNTLEEAKKASAVELPEPEPIGEDCPECGKPLVKKRGRFGEFIACSGYPECRYTKPILKTIGVKCPLCGETEGGEVVRRRSKKGKFFYGCSRYPECKYVSWNEPTGEKCKECGASLIRKNKKSLPECPECGWKKEKKGKKENK
(853) DNA topoisomerase 1 [Halanaerobium praevalens DSM 2228]
1
MAKKKKKLVIVESPAKAKTIKKFLGKDYKVEASMGHVRDLPKSKLGIDLESDFEPNYITIRGKGKTLNKLRKAAKKSKEVYLATDPDREGEAISWHLAYALKLSDQENNRIEFNEITKNAIQNAIKNPRNINKDLVDAQQARRLLDRIVGYRLSPLLWKKVRKGLSAGRVQSVAVKIICKREEEIRDFDEEEYWSLEVELKNDENQTLKADLYRIDNKKYNLATQEEVEQVVEAIKKEEFEIIKVKKRKRKRNPKSPFTTSTLQQRASTKLNFTAKKTMYIAQQLYEGIDIGSSGTVGLISYIRTDSTRLSNEAKKGAKDYILAEFGTDFLKKKKEKSKKNANAQDAHEAIRPTDTQRTPEKIKKHLSKDQFKLYDLIWKRFIASQMSSALYQNISAQFKVGEKYKFRVSGSRLLFPGHLILTGKEKEKDIDLPVLTEGEKYKLIKTNPEQHFTTPPPRFSEASLVKTLEEEGIGRPSTYAPTLSTIESRDYVKKEGRYFEPTELGETVTKLLTEYFPDVTDVEFTAELEKNLDEIENGNKDWKQILRDFYEPFYQRLENARENMESVNIVEETDEVCDKCGSPMVVKYGRYGKFLACSSYPECKNTKPYLVRTGVDCPDCEEGEIIERTSKKGRTFYGCSNYPDCNFMVWNKPVEKPCPKCKSLMVEKTTKAKGKHHKCTNKECGHIEKVD
(739) DNA topoisomerase 1 [Asticcacaulis excentricus CB 48]
1
MNLVIVESPAKAKTINKYLGKDYTVLASYGHVRDLPSKDGSVKPDEDFAMSWEVDAKASKRLSDIADAARKSERVILATDPDREGEAISWHVLEVLNKKKVLKEKVVERVTFNAITKASVQEAMAAPRQIDMELVEAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALKIIVDRELEIEKFKSEEYWTVDAEVSANSPPFTARLNVLNGKKLAKFDLENAEKAEAARKAISLSKFAVESVEQKPGKRTPPPPFTTSTLQQEAARKLGFSAQRTMQTAQKLYEGVDIGGETTGLITYMRTDGVFIDPAAIGEIRKAVGERFGSAYVPSEPRLYKVKAKNAQEAHEAIRPTSIFRRPETLRLEGDQARLYELIWKRTMAAQMEAARVEKTTIDLLNHDKSIGLRSTGQVITFDGYLALYEEGKDDETDEDGGRLPQLRTGTLVDVHDIKPAQHFTEPPPRYSEASLVKRMEELGIGRPSTYASILSVLRDRDYVRMDKNRFIPEDKGRLVTAFLDQFFSRYVQYDFTADLEEKLDLVSAGDLNWKALLREFWQDFHAKAGEISEFRVSEVLDRLNDALAPHIFPDKGDGSNPRACPTCGTGQLSLKTSRFGAFVGCSNYPECKYTRPVGNPENASEVAAASGDRELGRDPETGKVVALKIGRFGPYVQLGEAESKDDKPKRSSLPKAWPPASIDLDRALKLLSLPRKVGDHPEDGKPITAALGRFGPFIEHEKTYANLPSFDEIFEVGLNRAVVLLAEKRANAKGKASTVATLKELGAHPESGDAIQVMAGRYGPYVKCGKVNATIPKDTAPEDVTLEQALALIEAKGGVKKTAAKKTTAKKAAPAKKPATKKATTSKKAPAKKAKAEA
(1638) DNA topoisomerase 1 [Thermoanaerobacter mathranii subsp. mathranii str. A3]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFTPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNFTKFEAKFYGTKEDKVELKTKEDVDKVLAALSEEYTVDKIKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYANPGANYASKKANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDIQEEEEKTVPVLQEGTKLLLKELKPTQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDNKNLKPTELGFIVTDALKEFFTKIVDVKFTAEMEEQLDKIEEGQAKWYEVVQEFYNDFYKTLKIAEEQMEEIDIKEEVEVTDIKCEICGRPMVIKKGRYGKFLACSGFPECKNTKPLYEKIGVKCPKCGGEIVRKKSKKGRMYYACENAPNCDFILWDKPVEEKCPVCGSLLIEKNTKNIHILKCSNAECDYQKEVK
(1418) DNA topoisomerase 1 [Acetobacter pasteurianus IFO 3283-01]
1
MTDVVVVESPAKAKTINKYLGDGYTVLASFGHVRDLPPKDGSVLPDEDFAMKWQSDERGMKQVAAIAKALKGAHRLYLATDPDREGEAISWHVRAMLEERKALKGVDVQRVTFNEITKSAIRYAMEHPRDLDFPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFKPREYWSVIASLLTPAGAAFTARLTHLNGKKLDQFDLHNAELAEAAKKAVEAENLAVKSIERRKVRRNPQPPFTTSTLQQEASRKLGMSAQTTMRTAQQLYEGMDLGGETVGLITYMRTDGVTMAQEAINAIRQHIGQKIGTEYVPAKPRIYTSKVKNAQEAHEAVRPTDVSRTPESVARFLNNDQRRLYELVWKRAVASQMESASLDQVAVDIAGPSGQTVLRANGSIITFEGFLKLYREGRDDTEKAADDDARMLPSMQEKDPLKREKVDAEQHFTQPPPRYSEASLVKKMEELGIGRPSTYASILTVLQDRSYVRLENRRFIPEARGRLVTAFLVSFFERYVDTGFTASLEELLDDISGGRAQWKQVLAAFWNDFSKAVSGTKELTITDVLNALDKDLGPFFFPERADGSDPRVCPSCGTGRLGLKLGRYGAFIGCSNYPECQYTRRLTSDSAEEGDDAALKDGMRLLGQNPETGEDITVRQGPWGLYVQQGEPNPEDKKAKPKRASLPKNINGESITLDQALGLLSLPRLVGIHPETGEPIQAGLGRFGPFVKMGAVYGSLDKDDDVLTIGLNRAVDALAKKLASIRNLGVHPKDGEPVMVRKGRFGPYVQHGQMVATLPRGTDMDAVTLDEAVALLADKGKPLKAKAGAKKKATTTKTAAKKKTATKSTAKADAEGAEKAAPKKKAPAKKKATTTTRKKKAETE
(1061) DNA topoisomerase 1 [Edwardsiella ictaluri 93-146]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKGAASAGDKAKTKAKKNERDALVNRMGVDPYHGWQAHYEVLPGKEKVVSELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDGSRYSRVVFNEITKNAIQQAFSQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEREREIKAFVPEEYWELRADLAVGADVSFQAQVTHYNDKPFKPVNAAQSQAAVTALENARFAVREREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALNMVRAYIGDNFGAEYLPTDANVYASKDNSQEAHEAIRPSDVSVLADDLKGMEADALKLYQLIWRQFVSCQMTAAKYDASTITVQAADYTLKARGRTLRFDGWTRVLPQLRKGDEDRALPAVESGRALDLLQLQPSQHFTKPPARFSEASLVRELEKRGIGRPSTYAAIISTIQDRGYVRTDNRRFYAEKMGEIVTDRLEENFRELMSYDFTAHMEDGLDRVASAQADWKVMLDGFFSDFSQQLEVAEKPPEEGGMRPNPMVLTCIACPTCERQMGIRTASTGVFLGCSGYTLSPKERCKTTINLVPEAEVLNVLEGDDAETNALRAKRRCPKCGTAMDSYLIDNHRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGAEMHLKMGRFGKYMGCTNEACKNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAEAPQQDAQGNATLVRFSRKTKQQYVSSEKDGKATGWTAFFIDGKWVVSEKK
(1169) DNA topoisomerase 3 [Edwardsiella ictaluri 93-146]
10
MRLFIAEKPSLGRAIADVLPKPHRRADGYIQCGDGDVVTWCVGHLLEQAEPDAYDARYARWNLVDLPIVPQKWQLRPKASSAKQLKVIERLLRDAQQVVHAGDPDREGQLLVDEVLDFLALAPEKRRQVQRCLINDLNPQAVARALERLRDNHEFMPLCVSALARARADWLYGINMTRAYTLLGRNAGYNGVLSVGRVQTPVLGLVVRRDEEIAHFVAKDYYEVRAHIVTPSGERFWAQWQPSEACEPHQDEEGRLLNRALAEHVIARIQDKPARVTGYNDKRESEVAPLPFSLSALQIEAAKRFAMSAQQVLDICQRLYETHKLLTYPRSDSRHLPEEHFAGRHAVMAAIATHAPTLANLESVDVQRRNRCWDDNKVDAHHAIIPTARAGGVTLNEDERNIYQLVARQYLMQFCPDAQYRKCVIDLEIEGGGFIAKARFLSQAGWRALLGAKERDDEDEGMPLPVVARDDLLHCERGELMARQTQPPRHFTDATLLSAMTGIARFVQDKSLKKILRATDGLGTEATRAGIIELLFRRGFLHKKGRYIHASQTGSALIHCLPEMAGRPDMTAHWESTLTKISERGCRYQDFMHPLVETLQQLIHQARTAVNPRAFRDLPPIENGRSRRTKGTTASNKRKKA
(1383) DNA topoisomerase [Edwardsiella ictaluri 93-146]
4
MQLYLCEKPSQAKDIARVLGISKRGQGFISADNITVTWAIGHLLEQASPDAYGEQFGKPWRVDVLPVLPDNWKMVVKPQTRDQFTVISKLLKQAGEVIIATDADREGEVIARELLAYCGYRGAVRRLWLSALDEASIREALAGILPGENTAKLYDAGLGRSRADWLIGMNLTRLYTLIARESGVSDVLSVGRVQTPTLAIVVNRDKEIADFVPVPWWQVQVLLEKDGVRFRATWQAAAQYCDDEKRCVNKQAANAVGQLCQQQKGATVLEVSQKRDKTPAPLCFDLGTLQLVCSRKFGMGAKETLAVAQSLYETHKATTYPRTDCGYLPTSMQKEIPEVMGSVAKSDPSVAPVLAQLDRGFVSRVWNDKKITAHHAIIPTRQAFDLSRLSADELKVYQLIRQHYFAQFLPLQESDVTDASFNIGGQLFLAKGKVNVITGWTCLFQKEIQEDPPEDDDMALPALNKGDSCIVNGASVGDKVTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNAGLGTEATRAGVLETLFSRHYLEKKGKHIHATLLARELIAALPETLTSPGMTALWEQALDDIAQGKMSLDTFIQKQLQWTRHLVDKGRADTVKITAPVTPPCPVCKGLTRKRKGKNGDFWGCIRYPECNGIVAGKSGGKGRKIARGKKTVVNTEVELSASQ
(54) DNA topoisomerase 1 [Desulfarculus baarsii DSM 2075]
1
MPKNLLIVESPAKARTIGKYLGPDFIVKASVGHIVDLPPSELGVDLENGFQPHYRVIKGKDKVIKELRAAAAKAGEIFLAPDPDREGEAIAMHIAQQLGRPLESYHRVLFHELTKSAIAKAVAAPAKIDVDRYNSQQARRVLDRLVGYQISPLLWDKVKRGLSAGRVQSVSLRLVVERERAIQAFEPQEYWTVTAMLQGQQPPPFAARLARLAGKKFDPKNEKEAMAGVTAIQGQRFVVEKLTKRQRKQQPAPPFITSTLQQEAYRKLGFAPKYTMGLAQALYEGKQTSEGQMGLITYMRTDSTRLAAEAVATVRALIAARYGQEYLPAKPNAYKSKANAQEAHEAIRPTNAALTPELLEAYLSRDELRLYQLIWNRFVACQMAPAVYDQTQAEIVAGQGLLRASGQVLRFRGFTAVYVEDRDEHGGDEARASAEAKDHDQALPPLPPLDEGQELALQGVEPKQHFTQPPPRFTEASLVRELEEQGIGRPSTYAAILSTIQEKDYVSKDQKRRLIPTELGYLVNDLLVECFPQIMEVGFTAQLEGLLDQVEEGRQDWRGLLADFYGPFQQALGAAKTHMRQIKGKGVETDVKCPLCGKPMAIRLGRNGEFLACSGYPECKSTSDFSRDEKGAIVLQEAAPDPGVACDKCGAAMVVKKGRFGPFLACSAYPQCKNIMALGADGKPVAKPQPEATGEKCPKCGGELVIKPTRSGGRFISCANYPKCNYSKGLSTGVKCPKCGGELVEKRSRRGKPFYGCDNFPTCDYASWDRPIDEPCPQCGHPFLVEKVGKKETVVRCPQPDCNFKK
(651) DNA topoisomerase [Faecalibacterium prausnitzii SL3/3]
7
MVGINASRLFSCLYNQPLAVGRVMTPVLAMTVVREAAIAAFTPEKFYTVDLELTSGCTASSRRIPEKSVAENLLKACRKEMVATIQRITRKEKSENPPPLYDLTTLQRDANRLLGYSAQQTLDYVQSLYEKKLTTYPRTDSCYITDDDEEMLEELTEELEGFLDITSADVDEAVPRTRRTVNREKVTDHHAILPTRSMLQADLDALPKGEQNVLKLIIARTLMAVSKPFRYLETLLTTECAGEEFTAKGKEILEEGWKAVERKVLADILNRKQELTALPNAAENEYGILNAELKEGQTSPPKHFTEDTLLHAMETASADSMPEGVERQGIGTPATRAATIEKLVQKGFLERKGTKKTKVLLPTDKGKALITVMPEEIQSADMTADWEAKLLQIERSEMEPETFMTEIKEMISSLVTTTEAAKGANALMKNKIIGVCPNCGANVVEREKGWFCESNPCRFVLWKDNAFFKRLGKRLDGRMADKLLRDGHVRLKDCKSAKGKTYNATVLLSTEPDGRSKFSLEFEGGC
(1511) DNA topoisomerase [Faecalibacterium prausnitzii SL3/3]
7
MEDAAIREGFANLRPDSDYDALYQSALCRAKADWLVGINATRLFSVLYHKTLTVGRVQTPTLKMLVDRDAKILRFQKEKYYTVGIQSGSLKAGSGRIADAETANSLKEKCTGTTTVCTSVKREKKTEQPPKLYDLTTLQREVNRLFGFTAKQTLDYAQQLYEKKLLTYPRTDSQYLTEDMGQTVRHLVSDLLGLLPFAQRLVLTPDVSRVLNSNKVSDHHAIIPTAEFAKQGFTGLAESECKLMNLVCSKLLCAVAIPHEYETVTAVFSCAGNEFTAKGKTVLVPGWKEIDQRFRSTLKADTEEEVLNTLPELAEGQSFSVTANVSEHFTSPPKAYTEDTLLSAMEWAGAEDMPEDKVNCSAGAREGGLGQAERKGLGTPATRAAILEKLVQIGFVQRKGKQLVPTKDGINLAVVLPESLTSPALTAEWENRLTEIAKGNADPDEFMAEIEAQVHQLVKTYSCISADKQNLFQSERVIIGKCPRCGENVYDGKKNFYCGNRGCQFVMWKNDRFFEQRKKAFTPKIAAALLKNGKAKVKGLYSEKTGKTYDATVLLADTGGKYVNYRVERKE
(1654) DNA topoisomerase III, bacteria and conjugative plasmid [Faecalibacterium prausnitzii SL3/3]
7
MRYKLVIAEKPSVAQSLAAVIGATARKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGEMIFRSVYELADCQKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPVPFYTVALELPGLTVSGERMSDRASAEQMKEACQDAAVAIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVANAMPFCKEIAITCDPHTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACADGEFTAKGKTVKHPGWKALEDACRAKMKDAEPKKEGAEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLSAMETAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIEHGQLAPEEFLAGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQSKECRFAIWKNNKWWTAKKKQPTKAVVSALLKDGCVRVTGLYSEKTGKTYDATVVLEDDGQYANFKLEFDQRKGGSR
(1214) DNA topoisomerase 1 [Faecalibacterium prausnitzii SL3/3]
1
MAKLVIVESPAKAKTIGKYLGDDYEVTASMGHIRDLPASQLGIDVEHGYTPQYISIKGKEKLIKELKSKAKHADGVLLATDPDREGEAISWHLANILGLDPHEPNRVTFDEITKKGVKEGMAHPRAIDEDLFNAQQARRVLDRLVGYKLSPFLWRKVRRGLSAGRVQSVAVRLIDDREKEIENFKPDEYWNVDATLGAGHKSFVARLATDANGKKLLPKSEAEARAIEKGLEGASYVVSELKRGKRAKQPTPAFITSTLQQEASRRLGFTATRTMRAAQTLYEGVDIAGHGMMGLITYMRTDSLRISDEAVAAAKEYIAGAYGEAYICPYKRTWKTKSATAAQDAHEAIRPSVPSLTPDEVDKSISGDTAKLYRMIWSRFMASQMADCQQDTVSVTVSAADYHFKASGYTVTFDGFTALYEEATDEKEKKETNLPPLEQGQVLKLRELKSEQKFTQPPARYTEATLIKALEENGIGRPSTYAPIITTIIDRGYVERDQKKLKPTLLGRAVDGLMLEQFPHIVDVDFSAQMEKNLDKVESGKADWRKTVDDFYQGFEASLEQAEKNMEGKKVKVPDEPSSEVCDLCGRPMVIKVGKYGKFLACSGFPECRGTKRLVKDTGGICPKCGKGRLLERKSSKGRIYYGCECYPDCDFMTWDMPVATKCEKCGSTLFRKGGKLYCAKEGCGFEMPVPKKD
(329) Topoisomerase IA [Ruminococcus bromii L2-63]
2
MAFRLVIAEKPSVAQTIAAALGIKGKQDGYIEGGGYLISWCVGHLVQLAEAAAYGEQYKKMEF
(1286) DNA topoisomerase 1 [Ruminococcus bromii L2-63]
1
MSDLVIVESPAKAKTIKKYLGSGYEVVASMGHVRDLPKSRLSVDIKKNFAPKYEIIKGKEKLVDDLKSAAEKSEHIYLATDPDREGEAISWHLAYILGLPTDETNRVEFNEITKSGVTNGMSNPRSINIDLVNAQQARRILDRLVGYKLSPFISQKIRRGLSAGRVQSVAVRIIVDREEEIRKFKPEEYWSIDAKFIPKGSRKSFSASLYSDENGKIKITNGEQADKIEADLQNAEYVITKVKNGTRKKSPAPPFITSTLQQEASRKLGFQSRRTMKVAQELYEGVDIEGMGATGLITYMRTDSLRISNVAIEEVTEYIKNSYGEKFLPPKPRFFKSRSNAQDGHEAIRPSMPSLTPDSVKASLTSDQYKLYKLIWNRFTASQMADCIQKTTQADIVANGYTFKASGYRVDFEGFTTLYVESKDVEEEKTTQLPPLEKDMIVRCKELKKNQHFTQPPARYTEASLIKALEEYGIGRPSTYAATITTITSHEYVKREGKSLVPTELGEVTTNLMKERFPKIVNVKFTNQMEEDLDKVEKGTEEWHALLDNFYGDFDKTLKKAKADMEGVKLHLKEDETDIICDKCGRQMVVKVGRYGKFIACPGYPECKNIIKYVEKTGVKCPKCGGDVIIKRTKTKRIFYGCSNYPECDFVSWNEPTNEKCPQCGGILFKKKGKKPTLFCATEGCGYTKTADTDDK
(34) DNA topoisomerase [Ruminococcus bromii L2-63]
7
MKLVIAEKPSVGAAIAAVMGANEKRSGYFEGGGYLVSWCIGHLISLADAATYNEQFRKWKYDDLPIVPQEWQFIVASGKEQQFSILKDLMHRSDVTEIINACDSGREGELIFRFVYEQANCKKPFSRLWISSMEASAIREGFSNLKDGRGYDNLYQSALCRAKADWLIGINATRLFSILYHKTLNVGRVQTPTLAMLVNRDYAISSFKKEKYHVVRLDVGGVAALSERQDDEAAARQMKAACEKSQAVCTSLKKEKKTAAPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYPRTDSKYITSDMEGSTKELITGLCAALPFMQGVKLQADLARICDNSKVTDHHAILPTAEFVKTGFSSLAESEKKLMTLVCAKLLCAVAAPYEYEAVTAVFTCGGYTFTAKGRTTLCEGWREIERLSRAASGEQDEDAEPEAVLPPLAEGQTFDNPAAEISERYTQPPKAFTEDTLLSAMESAGKEDTPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLVAILPDSLTSPQLTAEWETRLTGIAKGSDSPADFMRGIEEMTAGLVKTYSAISEDKAKLFTPQREAIGTCPRCGAAVYEGKKNFYCSDRACSFVMWKNDRFFEQRKKAFTKAIAAALLKDGKVKIKGMYSTKTGKTFDGVVLLADTGGKYVNFRVEQNRK
(92) DNA topoisomerase III, bacteria and conjugative plasmid [Ruminococcus torques L2-14]
7
MAQHKLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGELIFRSVYELAGCKKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFQPVPFYTVALELPGLTVSGERMADKAAAKQLKETCRGANVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTSDMADSLPVLVNLVANAMPFRKGIAITCDPQTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACAGGEFTAKGKTVKHPGWKALEDAYRAKMKDAEPKKEGAEKALPELTEGQTLSVAAAIVKEGKSSPPQHFTEDTLLSAMETAGKENMPEEAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIERGQLAPEEFLDGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQNDSCKFAIWKNNKWWDAKKKQPTKAVVSALLNDGCVRVTGLYSEKTGKTYDAAVVLEDDGQYANFKLEFDQRKGGSR
(644) DNA topoisomerase 1 [Ruminococcus torques L2-14]
1
MAHYLVIVESPAKVKTIKKFLGSNYTVAASQGHVRDLPKSQLGIDVENDYEPKYITIRGKGEILATLRKEAKKSDKVYLATDPDREGEAISWHLAAALKLDEKKMRRITFNEITKNAVKASLKAPRDIDMDLVDAQQARRELDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIVADREAEIDAFIPEEYWSLDAQLKVKGEKRPLTAKFYGTEKKKMTIHSKEEMDEILKKLENEEFQITDIKNSERTRKAPLPFTTSTLQQEAAKALNFGTQKTMRIAQQLYEGVDIKGNGTVGVITYLRTDSTRISEEADAAARSYIAETYGEAYVAEGTKTKSADKKIQDAHEAIRPTDITRTPAAIKDSLSRDQFRLYQLIWKRFTASRMQPAKYETTAVKIGAGEYCFTVSTARVAFDGFRSVYVEAEEEKEESNVLVGHLSMDSVLTKEEFDPKQHFTQPPAHYTEASLVKTMEELGIGRPSTYAPTISLILGRRYITKEGKNLYLTEIGEVVNNIMKQSFPSIVDVHFTANMEGLLDMVEEGKVPWKEVIRNFYPDLEEAVEIAEKELEEVKIEDEVTDVICEECGRNMVIKYGPHGKFLACPGFPECRNTKPYLEKIGVPCPVCGKEVVIRKTKKGRKYYGCEDNPECEFMSWQKPSSKKCPECGGYMVEKGNKLVCADEKCGYVETIKKED
(489) DNA topoisomerase [Ruminococcus torques L2-14]
7
MGKSVYIAEKPSVAQEFAKALKLNTKRRDGYLESDEAIVTWCVGHLVTMSYPEEYDPALKRWNLQTLPFIPEEFKYEVIPSVAKQFQIVSGILNREDVDTIYVCTDSGREGEYIYRLVEQEAHVEGKKRRRVWIDSQTEEEILRGIREAKDLSEYDNLGASAYLRAKEDYLMGINFSRLLTLKYGNSISNFLQTKYSVISVGRVMTCVLGMVVRREREIRDFVKTPFYRVLSTIDAQGHTFEGEWRAVKGSRYFESYDLYKENGFKERKKAEELIQYLQTPDDESVNVAGIQRQLGLNCRIESIEKKKEKKNPPLLYNLAELQNDCSKRFKISPDETLRIVQELYEKKLVTYPRTDARVLSTAVAKEITRNLNGLSKYPMAAPYMQDILNFGSYKTLAKTRYVNDKQITDHYAIIPTGQGLNALSTVSSTAKGVYDLIVRRFLSIFYPPAVYQKVAIVTKIKEESFFSSFKVLAEEGYLKVAGIPKKKASQTATKDSSNGNSENTNNDTNDEAGSDSSDQSLDTGLFEVIKSLKKGAVLQVRALDIKEGETSPPKRYNSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLVNIKYLALNKKTQVITPTLQGEMIYDVVDHSIRSLLNPELTASWEKGLNYVAEGSITSDEYMRKLDHFITSRTVGVKGLNNQYQLRACYEKAAGFYPSVNNNKTIGRTKTGNKSK
(473) DNA topoisomerase III, bacteria and conjugative plasmid [Eubacterium siraeum 70/3]
7
MMRYKLVIAEKPSVAQSLAAVIGATARKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGEMIFRSVYELADCQKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPVPFYTVALELPGLTVSGERMSDRASAEQMKEACQDAAVAIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVANAMPFCKEIAITCDPHTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACADGEFTAKGKTVKHPGWKALEDACRAKMKDAEPKKEGAEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLSAMETAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIEHGQLAPEEFLAGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQSKECRFAIWKNNKWWTAKKKQPTKAVVSALLKDGCVRVTGLYSEKTGKTYDATVVLEDDGQYANFKLEFDQRKGGSR
(1507) DNA topoisomerase [Eubacterium siraeum 70/3]
3
MIVIYAEKYSLGRTIAEALGAYKKTVNPKEPSIAHWSLNLNGEEAILCHGAGHLCGLAPAEDYNESYKFWSFDNYPIIPEHFITRVKDNNYSRLAYDYVKQFFDKADLIINATDADREGELIFAYLYEVLHCTVPYKRVWITDLTPFKIRKAFAELRPAKDMKPLENAGRIRSATDWLVGINTSVAATLKFGGTDNVFACGRVKMPTLAMIVKREREIRNYVKKPFYKIVANIEATDGAKFTAEAADKYDTETAAKAVIDEIKLNTAKAIKVEVLQKQTAAPLLYNTTHLLADLSKCTDLTIDMLTKLVQSLYENRLITYPRTSSEHLTDAMKDETVKIIKLLFEMPEFAKYAIPVDNFAPCTRRHYDDSKVDSHTAITPTALVPNDLSGMSENERKAYTLLALSIIRTVYPKAVTENVKAVFQIDNQLFTATGTNIISPGWFAVDATPKVIGLPEIVKDNDYKVIGFDVKEGQNEPPKYYTDATLLTAMELAGDNIEDEQTRNLIKLEKRGLGTAATRQGIIKELYEKGYIARRTKKNGNMIKGIMPTEKGMYIIDALEKTVPDMLSVDMTSDMEMELDKIARGKSDGNDFLNNYKKLVAKWVELIKNSDTSAMAGNTLICPLCSKPLIKKKVGWCCTGYSKDNPDSCRFYIANEICGKKISDVIAKELTLKRSTSIIKGFTSQSGKTFDAKLTIKADNTIGFEFPERLKCPVCGKEMIKSSKGWVCTGYKNGCNFFIAGTICGKCITDTIATMLCANKRTRIINGFTSKSGKAFSAALIVKDGKIDFDFPAQSQKRSK
(1780) DNA topoisomerase 1 [Mahella australiensis 50-1 BON]
1
MANNLVIVESPAKAKTISKFLGRGYKVEASMGHVRDLPKSQMGIDIEHGFEPKYITIRGKGEIVDKLKKQAKAVDRVLLATDPDREGEAISWHLAQLLDIDMDKACRIEFHEITKNAIKDALKHVRPIDKNLVDAQQARRVLDRLVGYSISPLLWRKIRKGLSAGRVQSVALRLICDRQQEIDNFVPQEYWTLTALLASDKGETLEARFYGKDTKKQELKDKESVDAIIKDINGSDFIVEKIERGQRKRKASAPFVTSTLQQEAARKLRFTAKKTMAVAQQLYEGVELGKEGMVGLITYMRTDSVRVSQEARREARNYIAERFGDNYVPDKPNEFRNRKGTQDAHEAIRPTYINYTPDYVKSFLSRDQYRLYELIYNRFIASQMSDAVYDTISVTIKAGDYVFKASGSTLIFPGHLALYMEGQDDDNDDKEQKLPPLEEGQRLILKKWMPEQHFTQPPPLYTEASLVKMLEEKGIGRPSTYAPIISTIVERGYVVREKRTLKPTELGILVNDMLKEHFPDIVDVSFTAQMEQMLDDVEEGQKDWHNIISEFYFPFKSVLDKADQSIEKVDVPDEQSDVICEKCGRRMVIKQGRYGKFLACPGFPECRNTKPLLEELKVTCPKCGGHIQIKRSKRGRKFYGCENYPKCDFVSWDEPTGELCPECGYPVVIKYSKNGRKYTRCSNKDCKYTGQKLAGEAK
(1739) DNA topoisomerase III, bacteria and conjugative plasmid [Alistipes shahii WAL 8301]
7
MKTIIAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGVRGFVRDNLPIIPDTFTLVPRQVRTEKGYKPDSGVVSQIKVIKRLFDTSDQIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRNLEDGSKYDNLYLAAKARSESDWLVGINGTQALSIAAGHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQLHIATDGCGGEVVKFSSSEKWKEKEPAMELYNKVKAAGSATVTKAERKEKTEETPLLYDLTTLQKEANAKHGFTAEQTLEIAQKLYEKKLITYPRTGNRYIPEDVFAEIPKLLAFIGTQPEWKDKVRAKAAPTRRSVDGGKVTDHHALLVTGEKPLFLSKEDGIIYQMIAGRMIEAFSEKCVKDVTNITVECAGVEFIVKGSVIRQAGWRAVYGEDKEETTIPGWQEGDTLTLKASSITEGKTKPKPLHTEATLLAAMETAGKEIEDDALRQAMKDCGIGTPATRAAIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTMRIADVAMTGEWEKELARIERGELSADTFRKEIEAYTREITSELLSCDKLFAHKDSGCACPKCGTGRMRFYGKVVRCDNTECGLPVFRLKAGRTLSDDEIKDLLTDGHTKLLKGFKSKQGKSFDAIVAFDGEYNTTFVFPEKKSKASSPKKRK
(945) DNA topoisomerase III, bacteria and conjugative plasmid [Alistipes shahii WAL 8301]
7
MQVIIAEKPSVAREIAAIVGATNRKDGFIEGNGYAVTWAFGHLVGLAMPQQYGIAGFRRENLPILPSSFILLPRQVREGKEYKADPGVVKQLGILRELFGMAERIIVATDAGREGELIFRYIYSYLECRTPFVRLWISSLTDRAIREGLQHLRPGNEYDNLYLSAKARSEADWIVGINASQALAVAAGRGVWSLGRVQTPTLAIICSRYLENKAFKPAAYFRLKLSTAKEGTEFTVLSTEKFDGREKAEAARAEVIGARTVRVVNVERKETREQPPLLYDLTTLQKEANSRYGFSAEKTLDIAQSLYEKKFITYPRTGSRYISEDVAEEIPALIGNMTRYPRFAEYAGRMDTASLSRRSVDNEKIADHHALLPTENLPSELDADHRIVYEMVAGRMLETFSGACVKENTSLTLQSAGHDFTARGSIMVETGWRAVLNEPVEEKEEDMTLLPDIVQGDELPVKGCVTEQKQTRPRPLHTESSLLAAMETAGRELSDEAEREAMKDAGIGTPATRAAIIETLFAREYVRREKKSLVPTDKGLAVYAVVRDKKIADVAMTGGWELALSKIATGEMDAPTFHRGIEVFASQIAKELLEARIDGAESDTACPRCGRPVVFYPKLAKCQNPDCGLTVWRTVARKELTDKQLAELLTKGKTGTIRGFVKNGGGTFDAALTLDDQFKTSFVFEPRDTPRQGKRNKRK
(142) DNA topoisomerase 1 [Alistipes shahii WAL 8301]
1
MQENLVIVESPAKAKTIEKFLGKDFIVKSSFGHIRDLAKKDLGINIGEGYKPVYEIPGDKKKVVDELTKLAKSKTVWLASDEDREGEAIAWHLTEVLGLPVDRTKRIVFHEITKRAILEAIEKPRTVNMDLVNAQQARRILDRLVGFELSPVLWKKVRPALSAGRVQSVAVRLIVEREREIIAFRSAAYFRVVAQFYAAGDPEKTLFKAELSSRFETEAQAETFLQSCIGATFTVAKAEEKPAQRYPAPPFTTSTLQQEAGRKLGMSVSQTMSVAQHLYEQGLITYMRTDSVNLSQQALAQCKEEITKLYGEKYSRWFNYKTKTKGAQEAHEAIRPSYIERQEIEGTPAEKKLYDLIWKRTVASQMVCAELDRTTITIDMSGSSNQFVAQGEVVRFDGFLRLYSESTDDDQAAESGEGLLPKLTAGDRVLPSQITATERFTSAPARYNEASLVKRLEELGIGRPSTYAPTITTIINRGYVVKQNRDGQKRNYAQLTLTGEKIASKTLSENYGKEKNRLSPTDIGMVVNDYLEEQFGPIIDYNFTASVEKEFDRIAEGDITWDKMIDEFYGPFHKMVDSAITTQTAKTREVRILGNDPKTGHIVKARIGRYGPMVEIEGNEGEKGRFASLKKGQLIESITLEEALELFALPRDLGQLDGEELMVGIGKYGPYVRYGKSFASLAKTDDPYTIGYDRAVEIVRAHQAAAAAANTPMKSFPEDADMLVKNGRYGPYIAYKGKNYRLPKGAKPEELTLDDCLKIVAGSKK
(624) DNA topoisomerase 1 [Pseudoxanthomonas suwonensis 11-1]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPERGFAMRYDLIEKNEKHVEAIAKAARSADDIWLATDPDREGEAISWHIAEILKERGLLDGKPLRRVVFTEITPRAIKEAMTQPRTIAGELVDAQQARRALDYLVGFNLSPVLWRKVQPGLSAGRVQSPALRMIVEREEEIEAFKAREYWSIGAELAHAAQPFSAKLVKLDGQKFEQFTITDGESAEAARLRIQQAAAGALHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVTLGEEGTVGLISYMRTDSVNLSQEAVAEIRDVIARDYGTASVPDKPNTYQTKSKNAQEAHEAIRPTSALRTPGSVARFLTDDERRLYELVWKRAVASQMVPATLNTVSVDLAAGSDHVFRASGTTVVFPGFLAVYEEGKDTKTAEDEDEGRKLPPLKPGERVPLDRIHADQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLLFRKYAEMEGRAFRPTDVGRAVSKFLSGHFTRYVDYDFTARLEDELDAVSRGEEEWVPLMERFWAPFKELVEDKKESLDRTDAGSSRSLGIDPKSGKEVSARIGRFGPMVQIGTVDDEEKPKFASLQPGQSIYSISLEDALKLFDMPRNLGESNGQQVSVGIGRFGPFAKRGSTYASLKKEDDPYKIDLARAVELIEEKEEIARNRIIKEFPGSDIQVLNGRFGPYISDGKLNGKIPKDREPSTLTLEEVQQLLAETGKPARRGFGAKKAVARKAATKTAASKEAAPKKALAKKAPAKKAAKKATRKAAAKKAPAKKAAARATADDAPPF
(379) DNA topoisomerase 1 [Weissella koreensis KACC 15510]
1
MPTTTKDKPKAKKRTTTKRKKNLVIVESPSKAKTIEKYLGSGYKVVASIGHIRDLPKSQMGVDTENDYNPKYINIRGKGDVIKNLKKEAKAAKHVYLASDPDREGESIAWHLAHILDLDTSSEENRVVFNEITKDAVKDAFKRPRQLDMNLVNAQQARRILDRLVGYSISPLLWKKIKKGLSAGRVQSGALGLIIDRENDIQAFQPEEYWELPAEFKKSNKKFKAGFYGLDGQKVKRIPDNEMVQSILKRIDQNQEFDISEVVKSEGKNNPSPAFTTSTLQQAANTQLSFQTRRTMSTAQQLYEGINLGGKEGSVGLITYMRTDSTRISSIAKNDASKFIHEEYGDEYAATKPVQGKLQEGAQDAHEAVRPTSVFRTPKSIKDKLTNDQFKLYQLIWSRFVASQMTAEVIDRVRVTLTQNGVMFRANGATTKFAGYTKAYPAAKAKDNVLPEMVEGGNVKLDKINPEQKFTQPKPRYTEAALVKALEEAGVGRPSTYAATIETLKSRAYVKMDAKKFIPTEIGKMVQDAVRDYFPDVADLKFTAQIEGELDNVETGNEDWVKVVDEFYKPFKGELDIAESEMEKIVVKDKLAGENCEICGAPMLERLGRYGKFFACSRFPDCRNTKTIVKEIGLVCPKCHQGQIIERKTKRGRTFYGCSRYPDCEFISWDKPTEKTLADGTTPKDGEDNKKSKTTKSKKPATKKATKKKAAKK
(5) DNA topoisomerase [Weissella koreensis KACC 15510]
7
MRTIILAEKPTQAVAYSKAFKSSKKREGYIEVSNEYFDGETYITYGFGHLVELYLPEQYDEKYKNWSINNLPIIPDQFKFKTGKGKAEQFKIVKNLLSEADQIIIATDADREGENIAWSIINQSGINPQEKIMKRLWINSLESSAIRDGLTNLHEAKQHYSAYIEAQTREFSDWLVGMNASPLYSLSLRKQGIRGVFSIGRVQTPTLYMIYKRQVEIDNFKPKPYIELLAHVKTGKSEFEAKLDPFIRFDNQDKVKVFLSDNELVLVNKSQSKENNNNFGIINNIIKDKKKQPSPKLFSLSTLQSRANKAFKASAQNTLDAVQSLYEKKFLTYPRTDTQFISDEEFSYLLDNINQYCEFANVTANIAHKEPRKRYVNSKKVQEHHAIIPTRTIPTKNQFMKLTSLEKSIYELVLRTTIAMFLDDLNYDEQVIIVKSGQAQFKAMGRVITTPGWKLLFKTNSKKSSANGEVSLPRVDIGQKVDFDLLDEHKVTVAPSAYTEGTLITAMKNAGRDLADAQKEILKETEGIGTEATRAGIIERLKAKSYIELKDNSLAVTMSGIILCQAVELQPLLNSPELTAQWEMALHEIGQNNRTQASFLKQIEKFILKLINEVPDQIETNQKLTDQINSQKDTNADQYKEHMGICPVCKAGHMIDRGKFYGCSNYNSKEACNFSLPSKWAGKILPKTAIKDLIKKGHTKEISGFKSKAGKSFSAILELVDGKLKFVFDK
(301) DNA topoisomerase 1 [Francisella tularensis subsp. tularensis SCHU S4]
1
MAKNLVIVESPAKTKTIKKYLGNEFEILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKAAKDAQNIYLATDPDREGEAISWHVQEVLKSARLLKDKNIYRVTFNEITKSAVTNAIANPKELSMDLVDAQKARQALDFLVGFNISPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLLEFNNNKVEQFTFTTAEDAENAKAHILKDANGFLIVDGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIQAKYDKDMLPAKPRVFEKKSQNAQEAHEAIRVTAANRTPESIKQFLTNDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHRFRVTGTVIVDAGFLKIYNVEKDEDEKDSDDEQTLPKFEKGEKIILNDVITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQREYVEVDKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLSVLNNFWHPFIERINKISEDVSRKDVVQEELEEDCPECGSKLSLRLGKNGRFIGCTNYPTCKYTRPVDSDPKEVIKEEPIVVEDRKCPKCNSDLHIKQGRYGKFIGCSNYPECKHMEPLEKPKDTGVVCPKCNKNHIVEKKSRKGKVFYACAGFPKCKNAYWYPPIKEECPKCHSPILLHKITKKDGEQKACPNSECDYAVAFETK
(1238) DNA topoisomerase 1 [Cyanothece sp. PCC 7425]
1
MTNLLIVESPGKINKLRTILGSGWEVKASVGHIRELANDGPDSLGFDLGRDRIDCRYIPRNPRAKQAIAALKQAARQAQSVYLASDPDREGETIAWHIAEVLGLKQPQRIVFQEITATAVRTALSRPRPLDLNLVAAGRCRDCLDKLVGYKGSPLVWRLQNGAKSVGRVQSATLHLLCLREREISSFVPQTYWSVYVDYQEGFRAYYHHANQPPDPKASPEGIDEAGSQDSNKESTRVVSREAAEHLVVIARSQPHRVQQVSGQVTSKKPPPPFITSSLQQAAGSRLKFNPEYTMSLAQKLYEAGLITYMRTDSVQLSPEFCTAARSWLQEHDPENVPQRVARQRSSKAAQEGHEAIRPTDVFKSSAELRLQLEDDQFKLYVLIWTRAMASQCKSAQIRKTRILSQSGKVQWQATGQVIEFPGYTKYWKDISADLVLPEVTEGQPLHLETAQHEEKQTQPPPRYTEPKLVQLMERKGIGRPSTYAPTIATLKQRNYVHLLKDKLQPTDLGLQVDAFLETALPDLLKAEFTAAMESSLDAIAEGQQEWQRYLIDWNHTYFEPALQAALNRLPEHKGNTERKPLEKSRLKCPKCGQSMAKVPSQKVSKGYFLKCEVGCQTAAGKAMVMFWSARSKKWQLPEPHTEPQQENSDAKRQQDLQTKQLPVLTEHFCPVCNAYLEEYTYQREGQSKKLLRCSIPDHRQSKCKEATYFLTRQGEWWSKKFGQLE
(1072) DNA topoisomerase 1 [Cyanothece sp. PCC 7425]
1
MSTLVIVESPTKARTIRNYLPPEYRVEASMGHVRDLPKAASEIPAEVKQEKWANLGVNVEADFEPLYVIPKDKKKIVKELQDALKNVDRLLLATDEDREGESISWHLLQLLRPKVPAQRMVFHEITQEAIQAALQNCREIDERLVHAQETRRILDRLVGYTLSPLLWRKIPQAKETDRKLSAGRVQSVAVRLLVNREQQRRLFRKGSYWDLQATLAQHQSPFEARLVNLNGKRLATGSDFDENTGQLFPDRDVVLLNETQAQELQARLQEQTWRVTQLDERPQTRKPAPPFTTSTLQQEANRKLRLSAKDTMRIAQGLYERGFITYMRTDSVHLSEQAIAATRSCVEQMYGREYLSPQPRQYTTKSKGAQEAHEAIRPAGSSFRAPQQTGLEGADLELYELIWKRTVATQMAEARQTLITVQIQVENAGFRANGKRIDFPGFFRAYVEGSDDPDAALENREVILPPLQPGDTPTCRTLEAIAHETQPPARYTEATLVKTLESEGIGRPSTYASIISTIIDRGYAYRQGNALVPTFTAFAVTRLLEKHFPDLVDVGFTARMEQTLDDISTGGVDWLPYLRDFYLGENGLEHQVKEREVQIDPVEARTVELPGLEAKVRIGRYGPFIEVDNGTEPVTASLPLDITPANLDADQVELLLKQKLEGPDKLGIHPETGEPIYLLLGPYGFYVQLGDVSETNKKPKRAALPKGVDKAEVNLGLALDLLSMPRALGLHPETGGKISVGLGRFGPYVLHDQGKDNKEYRSLKKEDDPFTLSLERALALLAEPKTGRGRRSKTKEPLRELGPHPADGEPIRLFNGPYGPYVNHGKVNASLSEGEAPETVTLETALQLLSSKESTKKGTAKSKGTKTSKAAIAASTTTSKSSKASGKTTKTTKTTSRKSSSSQSTTSKNS
(1619) DNA topoisomerase 1 [Thiomicrospira crunogena XCL-2]
1
MTNLVIVESPAKAKTIEKYLGKGFTVRSSYGHIRDIQKKGMGIDIENGFMPNYEISPDKKKTVTELRKLTKEAETVWLATDEDREGEAIAWHLAEALKLDVNDTKRIVFHEITKTAIQKAIAEPRKVDMDLVEAQQARRILDRIVGFELSPILWKKIRTGLSAGRVQSVAVRLIVEREREIDAFESDYVYRLQGALDILDESQQVVGAVEVKRSAAFKTEEEAQAYLEQVKEAALTVSQLEEKPAKKSPKAPFTTSTLQQEASSKLGFSVKQTMMIAQRLYESGKITYMRTDSVNLSEEAIQKAHDEIVSEFGESYSTTRRYKTKNADAQEAHEAIRPTDFSVKSVTGERNEQRLYQLIWRRAIASQMADAQLKRTNVDIALEGMPAEKLVAKGEVITFDGFLKVYNLDDDAKEGQLPPLKVGQALKLGELLVRQSFSRPPARYNEASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVVKEDREGRQRDYRQLSLTVDGIDASTLTETTGTEKNKLFPTDIAGIVTDFLVKHFGDVLDYKFTALVESEFDTIAQGKESWQEMLTKFYQQFHPRVDAAEDVSREEAGQSRALGNDPKTGKPMFVKIGRFGPYVQLGDGENEEKPTFASLMPGQKMDTLKLEEALELFKLPREVGQMPESFSAKAVDGTEFAVEKGQIIIAKQGPFGPYLEYGPKMYAPIKGFDPLSIELEDAVALIESKIVTEAEKIIKVFPGTDVKILKGRWGPYITDVTTKKNAKIKKDEDALDLSLEECQKRLDEAPEPKKRGRVAAKKKAPAKKAAAKKTTAKKPAAKKPAAKKAPAKKTTRKTPAKKTSDKS
(1577) DNA topoisomerase 1 [Acaryochloris marina MBIC11017]
3
MSRLLIVESPGKIKKLRSILGSGWQVRASVGHIRQLANTGTGNLGFEAKNGQITCSYEPRDDRAKKTIADLKTAAKQADEIFIASDPDREGEVIGWHIAQVLGIKKPKRVVYQEITERAVQQAIAHPKSLDMDLVEAGRCRDCLDKLVGYRGSPLIWRLNNGAKSVGRVQSATLHLICQREREIQVFVPQDYWSVFVEYSEGFKAFYHGSMTGNEPDETTIEDAGSEAKTEESTRVTSQAAADALVEIAQAHPHHILSIEGKITPKKPPAPFTTSALQQAAGSRLKFSPEQTMQVAQKLYETGLITYMRTDSVILSPDYCAAAKKWLEQNDADNVPKKVAKQKGGKQTQEGHEAIRPTDIFKPSAELKQFLPEEQFKLYVLIWTRALASQCKPAQIRKTIVISQSGEVQWKAKGNLVEFKGYSKYWKDIKADTELPTLQPQQSLTLAQADSQQKQTQPPARYSEPKLVQLMEKKGIGRPSTYAPTIKTIKARGYVDLIKGKLQPTQIGMEVDQFMGGALPELLEAEFTAQMESSLDAIAQGNQEWQNYLIDWNRSYFAPALAKALKELPEPTGNYGGKVLQKSRTKCPGCSHPMSKVPSKKVKKKYFLKCENGCTADNGRGLVMFWSDRDKNWQVPQAKSDQPTPPAELTDYPCPACQQKMEIYSYHKDGQTKQMLRCSDPKARSDKKHKNAVYFQSKGRWWSPKYGELE
(856) DNA topoisomerase 1 [Acaryochloris marina MBIC11017]
8
MSTLVIVESPTKAKTIRNYLPSGYRVEASMGHVRDLPRTASEIPAAVKGEKWSSLGVNVQSDFEPLYVVPKDKKKIVKELKEALKNSDELVLATDEDREGESISWHLLQLLKPKVPTKRMVFHEITDEAIKAALTNCREVDQRLVRAQETRRILDRLVGYTLSPLLWKKIAPSLSAGRVQSVAVRLLVKRERERRAFRQGSYWDLKAALSKDKSSFESRLVTLADKRLATGNDFDENTGQIIAGRDVVLLNEEETLALQARLTDKTWSVAGVDERPSTRKPAPPFITSTLQQEANRKLRLSARETMRVAQSLYEKGFITYMRTDSVNLSQQAIAAARSCVEDLYGKNYLSPEPRQYKTKSKGAQEAHEAIRPAGQTFRTPKETDLQGAESKLYDLIWKRTVATQMAEARQTHITVHLEVEDAGFRSTGKRIDFPGFFRAYVEGSDDPDAALDDQEVLLPSLKQGDTPECTELSPIGHETQPPARFTEASLVKMLEKEGIGRPSTYASVIGTIIDRGYAQRQANALVPTFTAFAVTALLEQHFPDLVDLSFTARMERRLDGISTGEVEWLPYLSDFYLGDEGLETLVKTRQDQIDPGEARTIDLDNLEAKVRIGRFGPYIETEHEEKPVKASLPKDMTPADLTPEQIEQLLKQKLEGPEKLGFHPEKGEPIYILLGAYGPYVQLGDVTEENKKPKRASLPKGVAMESVTLDMAVELLSLPRLLGQHPDTGCKVQVGLGRFGPYVVHDQGKEGKDYRSLKKEDNLFTISFERALELLAMPKGTRGRRGTKKALKELGSHPEDEAPVNVYDGPYGPYIKHNKTNVSLPEGKKVEDVTLEMALPLLAEKASTKGKKKTSRAKSTTKKKTTKKTTAKKTTTKKTAAKKTTAKKTTKS
(1050) DNA topoisomerase 1 [Thermosynechococcus elongatus BP-1]
1
MSTLVIVESPAKARTIRKFLPPDYRVEASMGHVRDLPRSAADVPPEFRGEEWATLGVNVAAGFEPLYIVPKEKQKVIKELKAALKTADELLLATDEDREGESISWHLLQLLEPKVPVRRMVFHEITEEAIQEALHNCRDVNQQLVRAQETRRILDRLVGYTLSPLLWRKIAPHLSAGRVQSVAVRLLVQRERERLAFRKGQFWDLKATLDQRGTLFPARLVSVGGQRLATGNDFDPTTGQLRNPDAVLLLDEAAANALRDRLLTETWTVTEQEERQQTRKPAPPFTTSTLQQEANRKLHLSAQETMRIAQKLYEEGYITYMRTDSVHLSDQAIAAARSCVEAMYGKAFLSPQPRQYTTKTKGAQEAHEAIRPAGSQFRTPQETGLRDRELELYELIWKRTVASQMADARVTLLTVSITAGDALFRAHGKRIDFPGFFRAYVEGSDDPDAALESQEVMLPVMQVGDILRCQALESVRHETQPPPRYTEASLVKALEQAGIGRPSTYATIISTIQDREYAIRRGNALEPTFTAFAVTALLEKYFPDLVDINFTARMEQTLDDISTGEVQWQPYLESFYLGENGLEQQVKERERTIEATEARAIALPELNAEVVVGRFGPFVVYQNGNGSEPIKASLPQDATPGSLTREQVEQLIRQKLEGPDKLGVHPETGEPIFLLTGRFGPYVQLGEATEANPKPKRASLPKGVSPDEVTLDLAITLLSLPRTLGVHPETGKLIQANQGRFGPYIVHDPEGEKDYRSLKGEDDVYTITLERALELLATPKSSRARAKKQVLAVVGTHPEDGKLVQIFDGPYGPYVNHGKVNASLPEGVTPETMTLEQALLLLAEKAPKKTRRSATATAPKPKSTIKRTSKKTATQTANTSRRKSTET
(52) DNA topoisomerase 1 [Microcystis aeruginosa NIES-843]
1
MSTLVIVESPTKARTISNYLPSGYRVQASMGHIRDLPASAEEIPPAHKDKSWANLGVDVENDFDPLYVVPKTKSKVVKELKEALKGASELILATDEDREGESISWHLLQVLNPKIPTKRMVFHEITKEAIQAALKNCRSIDENLVHAQETRRILDRLYGYTLSPLLWKKISKGLSAGRVQSVAVRLLVQRERERRAFKTANYWDLKATLEKDKNQFESKLVTLNGQKVANGSDFDADTGRLLPGRQVTLLDQATAAALKERIEDKIWRVSHTEEKPTTRKPSPPFTTSTLQQEANRKLGISARDTMRIAQNLYEQGYITYMRTDSVHLSDQAITAARNCVEQMYGKNYLSPQPRQYTTKSKGAQEAHEAIRPAGSSFRLPRETGLSGLEFALYDLIWKRTVASQMADARITQIAVNIQVENAGFRSSGKRIDFPGFFRAYVEGSDDPEAAIDDQEIILPALSVGDTPNCRQLEAISHDTQPPARYSEASLVKTLESEGIGRPSTYATILGTIIDRGYAQMRNKTLIPTFTAFAVVSLLENHFPDLVDPKFTSKMEETLDDIATGSAQWLPYLDRFYRGEKGLESQVKERESQINSSTAKSVILEDLQATIKIGKYGPYLEVSRGDQILTASIPADLTPADLNPEQVETLLRQKTEGPDKLGLHPDSGEPIYLLVGSYGPYVQLGDVSDDNPKPKRASLPKGVKPEDVTLEQAVGLLALPRLLGTHPLTGGKIKASLGRFGPYIVQEQGKEKEYRSLKAGDDVLTITLDRALALLAEPKKTRSARGSTKPPLKELGKHPDDGESVGLYEGPYGVYIKHGKTNAKIPEGETAETLTLEQALVALAAKTTTAKKTTTKKTTSSTTKKTTSPGSKTSKSKTV
(1612) DNA topoisomerase 1 [Arthrospira platensis NIES-39]
1
MSTLVIVESPTKARTIRNFLPKDYQVEASMGHIRDLPPSADEIPEEYKGKTWAGLGVNVEGNFEPIYVIPKDKQKVVKELKKALKQATELVLATDEDREGESISWHLLQVLKPKIPTRRMVFHEITSEAILQALQHCRDLDEQLVHAQETRRILDRLYGYTLSPLLWKKIARGLSAGRVQSVAVRLIVNRERERRAFRQGGYWDLKALLEQGKTEFEAKLITLNGVKVATGSDFDESTGQIAQGRNVVLLDSDQAQALKERLREKLWSVRNIDERSVTRKPAPPFTTSTLQQEANRKLRLSARQTMQVAQGLYERGYITYMRTDSVHLSEQAIVAARNCVEQKYGKEYLSPKPRQYTTKSKGAQEAHEAIRPAGNYFRTPQETELSGNDLKLYDLIWKRTVASQMADSRQTNISVDLQVEDAGFRATGKRIDFPGFLRAYVEGSDDPDAALENQELPLPPLKVGQHPDCKDLEAIGHETQPPARFTEASLVKTLESEGVGRPSTYASVIGTIIDRGYAQIKGNALIPTFTAFAVNSLLEKHFPDLVDIGFTARMENTLDEIATGQADQLPYLQKFYSGDGGLENQVKEQESQIDAKVARTIELENLGDATDGMTYRLCLGRFGPYIEAQKDEEIITASIPQDLTPADLTPELIQELIGQKTEGPEKLGVHPEAGEPIFMLIGPYGPYVQLGEESETNKKPKRVSLPKGLEKDAVTLDVAVSLLSLPRLLGLHPETGAKVKAAIGRFGPYVVHESKEAKDYRSIKAPDDVLTITFERALELLAQPKVGRRGTKKTLTPLRELGEHPEDGEPLNIYDGRYGPYIKHGKINASLPKDQAIETFTLEQALELLKAKAASGSKSKSKSKSTSSTTAKKSTTAKKSTTAKKSTTAKKSTTAKKSTTAKKSTTAKKSTTAKKSSTKGETE
(615) DNA topoisomerase 1 [Gloeobacter violaceus PCC 7421]
1
MSKSLVIVESPAKAKTISKILGKNFVVKASAGHIRDLPQKEMGVNVKNDFEPKYVIIPKKEEVVEELKGAARNADRVYLAPDPDREGEAIAWHLAQILDIPGDRLQRIEFHEITKQAIQNAVAHPRDIDINRVDAQQARRILDRLVGYKLSPLLWKKVQRGLSAGRVQSVAVRLLCDREKEIQAFVSEEYWTVHGRFRQSAQVEATPFSADLVRWSGKKPDLGNETAARAVVEVLTGAASRVDSVKTRERQKEPQPPFITSTLQREGASALGLTVKRTMAIAQQLYEGIDLGEEGPVGLITYMRTDSTRVAEEAQEAAREFILAAYGKSYYPSRRRQYGAKKGAQDAHECVRPTDINRPPDAIKKSLTPDQFKLYRLIWQRFTASQMTAATLETRTVEIAATPTAGRPDALFRVSVTRTIFDGYTRVYEEAREEAATGDEEAAGAAPVLEEGEALTLLTVDPKQHFTQPPARFSEATLVKALEEQGIGRPSTYAPTIGTIQERGYVNKDGRTLIPTDLGMKVNDQLVQHFPNIVDTEFTANMEAQLDEVEKGSQRWTQLLADFYGPFVETLKAADEEMKRVVIVTDHLCESCGRPLLNRYGRFGNFLGCSGYPECDFTHQLTRDNKPVPKDRPAEGISCNQCGHAPMLITYGRYGEYLKCPACGKSQPKSTGITCPKCSKGQIVERRSKMGKNFYGCDQYPDCDFVLWSRPIDKPACPECGSILLYKPRKRGDDMVACSACKFTAPAQEMVGEEEVERQAELLTG
(1491) DNA topoisomerase 1 [Gloeobacter violaceus PCC 7421]
1
MMRLLICESPGKIKTFKAILGAGWDVQASLGHVMELANDGADHLGFDVGPEAITCRYVPRGERGMATLKKLRTAAAKAQEVYLATDPDREGEAIAWHLARELRLKSPRRIRCTQITEGAVRTALQSPGRLDMDLVSAQRARQCLDKLVGYKVSPLLWNATGGKSAGRVQSATLHFVCEREREIIAFVPVDYWSVWVEYAPGWRAYYQGDVQETPESTEATDDAKSNKEAPPAESTRVLSEAEADRLVALARSHPHAVERVERRTVTKIPPAPFTTSTLQQAAGALLSYNPERTMGIAQQLYEGIDLPTGRKGLITYMRTDSVEVAPEFVEQARTYLQINDPDNLPARSATHRSRAGAQQAHEAIRPTDVSLTPRTIRAHLSEEQLRLYDIVWRRAVASQCAPARLAKTKILTRSGPVHWQALGMTVAFAGYTRYWNDLEAALALPALEAGQNLELLRSAHEKKRTQPPPRYSEPKLVQLMERKGVGRPSTYASTIKTLKERAYVELQGRALVPTELGLATDALLGRTLPELVDSAFTARMETGLDAIAASREPWEKYLIGWNTDYLVPAVARARAAIAAEFPKRPAAPRTAQAPQISRTPCPRCRQALSKVPSKKVKRGYFLKCPACADLVMFWNPWRKIWELPKPKTDPQTP
(1545) DNA topoisomerase 1 [Acinetobacter calcoaceticus PHEA-2]
9
MANTSRSASQSTASTAPAAHKRALVIVESPAKAKTINKYLGSQYIVKSSVGHVRDLPTGGSKSTEKKLAARTKLTEAEKEQKASQALVNRMGVDPEHGWEAHYEVLPGKENVVAELKKLAKDADAIYLATDLDREGEAIAWHLREVIGGDDSRYHRVVFNEITKNAIQEAFKQPTRLDLNRVNAQQARRFLDRVVGFMVSPLLWEKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWQVFADTQAKKDDIRLEAVKQAGKTLKLKNKAETDALLDVLKGAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEAGFITYMRTDSTFLSDDAVSMVRAHIENQFGEKYLPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGVERDAQRLYDLIWRQFVACQMTPAEYLSSTLTVEAANVELKAKGRTLVFDGFTRVRGANKSDDDIILPAIKVGEILKLEKLDPSQHFTKPPARFTEASLVKELEKRSIGRPSTYAAIISTIQERGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDKVATGERNWKELLDTFYGDFKKRLTNAQGEHGMRRNQPVEVPAVHCPECSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAALSDDDGAETADLMSKHRCAKCGTAMDSYVIDGGRKLHVCGNNPDCNGFELEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKSGQPAPPRVEPIKMEHLRSTKHDDYFVLRDGAAGLFLAASKFPKIRETRAPKVAELRSVAAQLDPKYQFILQAPDVDPEGNPTVVKFSRKNQSQYVGSETPEGKQTKWSLIYQNGKWVEG
(485) DNA topoisomerase 1 [Candidatus Atelocyanobacterium thalassa]
1
MSTLVIVESPTKARTIRNFLPSEYQVEASMGHIRDLPASASEIPASYKGKSWANLGVDVENNFDPIYVIPKDKKKVVQGLKTALKSVDELILATDEDREGESISWHLLQILKPKVPIKRMVFHEITKDAIQESLENCRDINENLVHAQETRRVLDRLYGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVQKERERLSFQSGEYWNLKVLLKKEEIFFEAKLISISGKKIAIGSDFDPKTGGLAGNRNIILLDEQEANILKEQLKDTNKTWNVVKVEEKKVSNKPFPPFTTSTLQQESNRKLGISARDTMRIAQKLYEEGYITYMRTDSVNLSSEAINAARKCVKKKYGEEFLSPHPRKYTTVSKGAQEAHEAIRPAGNIFLIPKETGLTDQRLSLYDLIWKRTVACQMADAQLTQVSVIIAVENAEFRAYGKRIDFPGFFRAYVEGSDNPEIALENQEIILPYLQEGEHLKCEQVDAISHKTQPPARYTEASLVKILEKEGIGRPSTYASIIGTICDRGYSQMRSKALVPTFTAFAVVSLLETYFPELVDPMFTSKMEQALDEIATGEVLRVPYLEKFYFGDKGLDTQVKVRTDEINPSLAKAINLHNLDTTIKIGKFGPYIEVEQNEKIITASIPADLTPSDLNIDQVTKILKQKTEGPEKIGLHPDIGEPIYLLIGSYGPYVQLGEITEENKKPKRTSLPKSIKPEDVNLEIALGLLALPRLLGTHPDTQASIKVNIGRFGSYVVHDQGKEGKDYRSLKKEDDLLTISFERALELLSQPKLTRGRRTKKPLKELGLHPEDNEPINIYEGPYGVYINHKKINVSLSKKDKIDDITLEKALKLLLKKTPAKKTPAKKTPAKKATAKKATAKKIN
(528) DNA topoisomerase 1 [Pseudomonas aeruginosa NCGM2.S1]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGSSSSKEPAAKGRKSASEAPALSPKEKARRQLVSRMGVDPEHGWKAKYEILPGKEKVIDELRRLAKDADTVYLATDLDREGEAIAWHLREAIGGDESRYKRVVFNEITKKAIQEAFSQPGELDINRVNAQQARRFLDRVVGYMVSPLLWQKIARGLSAGRVQSVAVKLVVEREREIRAFVPEEYWEVHADLGTAKGANVRFEVTREKGEAFKPLNEAQAMAALEKLKASAYSVAKREDRPTSSRPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAIGMVRGFIEDEFGQKYLPGKANVYSSKEGAQEAHEAIRPSDVNLKPTQLSGMERDAERLYDLIWRQFVACQMTPAEYLSTSVSVTAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMKEGENLKLIKLDPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQERGYVTTHNRRFYAEKMGDIVTDRLNESFANLMDYGFTAGMEEHLDDVAQGERDWKHLLDEFYGDFKKKLEVAEVSEKGMRANQPTLTNIPCRECGRPMMIRTASTGVFLGCSGYSLPPKERCKATVNLIPGDEIAADDEGESESRVLRGKHRCPICSTAMDAYLLDEKHKLHICGNNPDCPGYEIEEGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKNGEAAPPKMDAIRMPELKCEKVDDIYVLRDGASGMFLAASQFPKNRETRAPLVSEIIPHKAELDPKYHYLCDAPQKDPDGRPAVIRFSRKTKEQYVQSEVDGKPTGWRAFYDGGKWKVEDKR
(1177) DNA topoisomerase [Pseudomonas aeruginosa NCGM2.S1]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTITWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSVPFWAIDVSLSAEGQAFAAQWVAPDDCTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVGTERVREGPPLLFDLSTLQEVCSRQVGLDVQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLLNTDPSLRPIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSALSEKELAVYRLIRAHYLAQFLPHHEFDRTVAEFSCGQQTLVATGKQVVVKGWRLVLAEPQADEDGDDTARSQVLPPLREGLACQVAEVEIKALKTMPAKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQLIAQYGCVSLSIKLSHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTPKRGASRSRSSGRKGA
(676) DNA topoisomerase 1 [Pseudomonas mendocina NK-01]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGSASATKEPAKRGKAVAGEAPALSPKEKAKRQLFARMGVDPEHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLRESIGGDDSRYKRVVFNEITKKAIQEAFSKPGELDINRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVAREKEIRAFVPEEYWEVHADLGTAKNAKVRFEVVREGGAAFKPVNEAQAMAALEKLKASSYSVVKREDRPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSNDAVEMVRGFIGSEYGDKYLPGKPNLYSSKEGAQEAHEAIRPSDVNLRPTQLSSMERDAERLYDLIWRQFVACQMPPAEYLSTSVTVAAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMKEGEGLKLIQLDPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVTVHNRRFYAEKMGDIVTERLDESFANLMDYSFTATMEGHLDDVAQGEREWKNLLDEFYGDFKKKLEAAEAGEGGMRANQPTLTDIPCRECGRPMMIRTASTGVFLGCSGYALPPKERCKATINLVPGDEIAADDEGESESRVLLGKHRCPICSTAMDAYLLDETRKLHICGNNPDCTGYEIEQGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPSCKNTRKLLKNGEAAPPKMDKVEMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVLEIVPHKHEIDPKYHFLCDAPQKDPDGRPAVIRYSRKTKEQYVQSEVDGKPTGWRAFYDGGKWKVEDKR
(159) DNA topoisomerase 1 [Pseudomonas brassicacearum subsp. brassicacearum NFM421]
9
MGKSLVIVESPAKAKTINKYLGDQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKAAAGEAPALSPKDKARKQLVSRMGVDPEHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEVHADLGTAKGATVRFDVAREKGEAFKPLNEAQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSVDAVAMARTYIESEFGKKYLPDTPNVYSSKEGAQEAHEAIRPSDANTEPSKLSGMERDAERLYELIWRQFLACQMLPAQYLSTTVSVGAGDFELRAKGRILKFDGYTRVMPQITKPGDDDVLPDMAQGDVMKLIKLDPTQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTERLSESFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFKKKLEVAESPDSGMRANQPVMTDIPCLTCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESLVLRGKHRCPICSTAMDAYLLDEKRKLHICGNNPDCAGYEIEEGTYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKSGDAAPPKMDPVKMPELKCEKVNDTYILRDGASGLFLAASQFPKNRETRAPLVMEIVPHKDEIDPKYHFLCEAPQKDPEGRPAVIRYSRKTKEQYVQTEVDGKPTGWKAFYDGGKWTVQDKS
(56) DNA topoisomerase [Pseudomonas brassicacearum subsp. brassicacearum NFM421]
4
MRLFLCEKPSQGKDIARVLGALRRGNGCYNGPGISVTWCIGHLVEAAPPEAYDERFKRWSLDQLPIVPTNWRVDVKADTAAQYKVVKQLLAKTTELVIATDADREGEMIAREILELCHYQGSIRRLWLSALNEASIRKALTGLRPADETERLYHSALARSRADWLVGMNMSRLFTLLAQRSGHHGVLSVGRVQTPTLRLVVDRDREIERFVPMHYWGIDVHLSYQEQLFLAQWVAPDCATDDAGRCIRQAMAQQALQSVRQAQRAQVLDMQMDRIREAPPLPFDLGTLQEVCSRRFGLGVQQTLEIAQSLYETHKATTYPRSDSGYLPESMWDEASTVLDALIISDPSVEALVQSVNRQQRSRAWNDSKVSAHHGIIPTLEPFQIEALSEKERAVYELIRAHYLAQFLPHHEYDRSCALFTCGGHTLRAHGKQIVASGWHRALAPDSTTSDDDSAQRNQILPPLSTGSDCNVSQVELRTLKTQAPKALTQGELIKAMKGVAKLVTDPRLKRTLKETTGIGTEATRANIISGLLNRGYLYMKGRSVRASDAAFTLIDAVPAAIADPATTAIWEQAFDMIENGQMTLDCFIAKQTAWITQLVEHYRTTTLLIHTPGGPNCPLCGASMRQRQGKHGSFWSCSRYPECKGALPVVTKTTLAPRRRKPRHSKPKGY
(1864) DNA topoisomerase [Pseudomonas brassicacearum subsp. brassicacearum NFM421]
4
MQLYLCEKPSQAKDIAAVLGATRRGDGCWLGPGITVTWCIGHLLETAPPDAYDARYKRWVLADLPIVPAQWKMTVKPKTASQYKAVKRLLGEAKELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDEASIRKALAALKPGAETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPIAYWAIDVQLSHEGTAFTAQWRADPDACDDQERCLNQALARDAAMAMSNAASARTLKVRTERLREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQSLYETYKLITYPRSDCGFLPLSQHSEAPAILAALAQADPSLAPLREHLQPQRKSRAWNDAKVSAHHGIIPTAAARNLDKLAGKQRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKQIVEPGWKRALPEALAPARGREAPAPQTLPALAEGRDCAVDEVKPKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTRQAAWMSKHVARCQGMSLTISGPASPAGRGATPWKNKRKPAKRKAGGAPRKASKAKAT
(939) DNA topoisomerase 1 [Prochlorococcus marinus str. AS9601]
1
MDHTLVIVESPTKAKTIRKFLPSNYEVLASMGHVRDLPKGAAEIPASVKKEKWSRIGVNTTEDFEPLYIVPKDKKKVVKELKDALKGATQLLLATDEDREGESISWHLLQILKPKIPTKRMVFHEITKKAINKALDQTREIDMELVQAQETRRILDRLFGYELSPLLWKKVAPRLSAGRVQSVSVRLLVRRERERRSFKKASYWGIKASLVKDNITFETKLFSLKGQRICNGSDFDEQTGKLKEGNKSLIIGEEQVNDLLNTFSSEDWLVSKIEKKPSTRKPVPPFTTSTLQQEANRKLRLSSRETMRCAQGLYERGFITYMRTDSVHLSEQATRAARECVSSMYGKEYLSNSPRQFNSTARNAQEAHEAIRPAGEVFKTPKETNLTGRDLSLYDLIWKRTVASQMAEARLTMINAEISVGYGLFKSSGKSIDFPGFFRAYVEGSDDPSSSLEQQEIILPNLTTGTCLEVTSKESTFHETKPPARYTEAALVKVLEKEGIGRPSTYASIIGTIVDRGYANISSNTLAPTFTAFAVTALLEEHFPDLVDTTFTAKMESSLDEISSGNLEWLPYLETFYKGKNGLEIKVQKTEGNIDGKAYRQVDFEDLPCVVRIGSNGPWLEGTKIDESGNEIQAKGNLPMDITPGDLDIKQVDQILSGPSDLGTDPKTGEKVFLRFGPYGPYVQLGNNDQDKAKPRRASLPKELKTDDLTLDEALVLLSLPRLLGAHPEGGVVEADRGRFGPYIKWIKNENESENRSLKKEDDVFRVDIKRALEILAMPKMGRGGQEVLKDFGKPKEFKEKIQILNGRYGVYLKCGKTNVSIAKDTDIEKFTIDEAVSLLEEKLKDKKGAILKKTKISNKKTSRKKKS
(1597) DNA topoisomerase 1 [Nostoc sp. PCC 7120]
1
MSTLVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASEIPASVKGEAWAQLGVNVDADFEPVYVVPKDKKKVVTQLKEALKDADELILATDEDREGESISWHLFQLLKPKVPTKRMVFHEITQEAIKKALKDCRNIDEQLVRAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVTKERQRRAFHEGTYWDLKAYLEQSKSPFTAQLTTLAGTKVATGSDFDASTGRITAGRNVVLLSETEAVALQERLTGKPWNVSEVEERPVTRKPAPPFTTSTLQQESNRKLRLSARDTMRIAQNLYEQGYITYMRTDSVHLSEQAIAAARNCVEQLYGKQYLSPQKRQYTTKSKGAQEAHEAIRPAGSTFRTPQETGLGGRELALYDLIWKRTVACQMADSRQTQITVQLQVEDAGFRASGKRIDFPGYLRAYVEGSDDPEAALEDQEVILPSLKVGDHPDCQNIEAVGHETQPPARYTEATLVKTLESEGIGRPSTYASIIGTIIDKGYSQLVNNALIPTFTAFAVTDLLEKNFPDIVDPSFTSKMEQTLDDIADGEVEWLPYLKKFYLGDKGLETLVRERESLIDASKARTVELENLDAKVRIGKYGPYIEVENGDGVVTASIPKDLTPADLDPKQVEIILRQKTVGPDQLGRHPETGEPIYVKIGAYGPYVQLGDKSDENPKPKQASLPKGVTPENITLEKAIGLLSLPRTLGTHPGTGGKIQASLGRFGPYVVHDQGKEGKDYRSLKASDDVLTISLERALELISEPKKTRGSTSSKSKAALRELGTHPEDDAPINIYDGPYGPYIKHGKTNVGLPEGTSMEDVTLATALELLSAKTATAKTTRKTSKTSTTKSKSTAKSSNAATKKKGA
(1154) DNA topoisomerase 1 [Nostoc sp. PCC 7120]
3
MPKRLLVVESPGKVKKLSQILGSEWIVRASCGHIRELSDEGEDALGFSMDGSSVQCHYVPRDQRSKETIQQLKSAAKQVSEVVLGTDPDREGETIAWHLKEVLGLREPKRVVYTEITASAVQSAIAHPRKLDLNLVGAGLCRDCLDKLVGYKGSPLVWALNNGAKSVGRVQSSTLHLICQREREIQSFVPQDYWSVWVDYVEGFRAFYKGAVNTRSNSPEAEVEIHDDAAGNSTTAPESTRVLAEAEANRLVEEARRHPHQIVQYEGKVANRQPPPPFITSTLQQAAGSKLKFAPEKTMQLAQKLYEAGLITYMRTDSVMLSPEFCESARQWLEQNDPQNVPTQVARHRSSKTAQQGHEAIRPTDVFRPSAQLRIELSTDEFNLYVMIWKRAIASQCRPAQLRKTVVITQSGQILWQARGQVVEFLGYTRYWPNLSKDTLLPTLQQGQMVTLENAGHEKKQTQPPPRYSEPKLVQLMERKGIGRPSTYSPTIATLKKRGYVELTKDNLHPTNLGLEVDTFLQKALPDLLEAEFTAKMENALDAIAEGKQPWQIYLTTWNQNYFAPALAKAKTVTVDSGKTTKTFPARQYDTSRTRCPDCNNFLSKIPSSKLKKKYFLKCTSGCENTVLFWSEFSKTWQAPRTKDDKMAENGEKNHLSPSTKLPTQLTAYPCPVCKKPLEEYTYTKDGQKKTMLRCSASSSRTDKKHKDVAYFHTAKGWWSPKFGEIT
(1235) DNA topoisomerase [Pseudomonas fluorescens F113]
4
MRLFLCEKPSQGRDIAKVLGASRRGDGCLIGRETTVTWCIGHLLETAPPEAYGDQYKTWSLDHLPIIPAQWRVEVKPKTVAQFKIIKHLLSEATTVVIATDADREGEMIARELLELCNYRGSVERLWLSALNEASIRKALSSLKSSQETFPLYHSALARSRADWLIGMNLSRLFTLLGRRAGYGAVLSVGRVQTPTLRLVVERDRAIASFVSVPYWVVNAHLSSMGQQPFIASWIPPSSGRDEAGRCLQQALASQALQAISSSKTATVVSLRTEHLREAPPLPFDLSTLQEVCSRKLGLGAQETLNIAQALYETHKATSYPRSDCRYLPESMFNEVAAVFDALLRMDPALRPALGSIDQSLRSRAWNDAKVTAHHGIIPTTEPANLGRMSEQERQVYELIRSHYLAQFLPHHEFDRTEVELECSAERLTAVGKQILVQGWKGLLSDNPDDDEPSQKSQVLPALQQGRQCAVDDVELKSMRTAAPKSLTEGDLIKAMKNVAKLVNDPRLKQKLRDTTGIGTEATRAGIIKGLIDRGYLLKKKRALMASATAHTLIEAVPAAVADPGMTAIWEQALDEIEAGRLSLDAFVAKQAHWITQLIANCGALTLSVPVEAGPVCPICNASMLRRKGKSGPFWSCSHYPDCKGTVPISKGIRRP
(411) DNA topoisomerase 1 [Pseudomonas fluorescens F113]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKAAAGEAPALSPKDKARKQLVSRMGVDPEHGWKARYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEVHADLGTAKGATVRFDVAREKGEAFKPLNEAQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSVDAVAMARTYIESEFGKKYLPDTPNVYSSKEGAQEAHEAIRPSDANTEPSKLSGMERDAERLYELIWRQFLACQMLPAQYLSTTVSVGAGDFELRAKGRILKFDGYTRVMPQITKPGDDDVLPDMAQGDVMKLIKLDPTQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTERLSESFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFKKKLEVAESPDSGMRANQPVMTDIPCLTCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESLVLRGKHRCPICSTAMDAYLLDEKRKLHICGNNPDCAGYEIEEGTYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKSGDAAPPKMDPVKMPELKCEKVNDTYILRDGASGLFLAASQFPKNRETRAPLVMEIVPHKDEIDPKYHFLCAAPQKDPEGRPAVIRYSRKTKEQYVQTEVDGKPTGWKAFYDGGKWTVQDKS
(1122) DNA topoisomerase [Pseudomonas fluorescens F113]
4
MQLYLCEKPSQAKDIAAVLGATRRGDGCWLGPGITVTWCIGHLLETAPPDAYDARYKRWVLADLPIVPAQWKMTVKPKTASQYKAVKRLLGEAKELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDEASIRKALAALKPGAETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVAYWAIDVQLSHEGTAFTAQWRADPDACDDQERCLNQALARDAAQAMANATTARTLKVRTERLREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQSLYETYKLITYPRSDCGFLPLSQHSEAPAILAALAQADPSLAPLREHLQPQRKSRAWNDAKVSAHHGIIPTAAARNLDKLAGKQRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKQIVEPGWKRALPEALAPARGREAPTPQTLPALSEGRDCAVDEVKPKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTRQAAWMSKHVARCQGMSLTISGPASPAGRGATPWKNKRKPAKRKTSGAPRKPSKAKAT
(1616) DNA topoisomerase [Pseudomonas stutzeri A1501]
4
MTVTWCIGHLLETAPPDAYDPRYKRWVLADLPIVPERWKMLVKPKTASQFKAVKRLLGECRELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDDASIRKALAALKPGAETFNLYHAALGRSRADWLIGMNMSRLFTLLGRQSGYRGVLPVGRVQTPTLRLVVDRDRSIADFIPVPFWAIDVQLLADGAAFTAQWQAPDDLCDDQGRCLDQARAQQAADAMRNAASARLLKLKTERQREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQALYETHKLITYPRSDCGYLPLSQLGEARAIVAALTQADPTLAALQPHLDLSRRSRAWNDAKVGAHHGIVPTAAARGLERLAGRPRAVYELIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKRVVEPGWKRAMPEALAPARGNREAHAPQSLPALQQGQDYAVGEITLKDQQTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQGLLDRGYLVRQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMPLEEFVAKQSAWMSKLVERCAGLRMTISGPPVAAGRNGKPWKKKRSATPRRGSGARTRKPRAAD
(1234) DNA topoisomerase 1 [Pseudomonas stutzeri A1501]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSANKEPVKRGKAAAAEAPALSPKEKAKRQLIARMGVDPEHGWKAKYEILPGKEKVIEELRRLAKEADTIYLATDLDREGEAIAWHLRESIGGDDSRYKRVVFNEITKKAIQEAFSQPGELDLNRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFVPEEYWEVHADLATAQQAKVRFEVAREKGEAFKPLNEAQANAALEKLKGASYSVTKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAISMVRGFIEGEFGDKYLPEKPNLYSSKEGAQEAHEAIRPSDVNLRPNQLSGMERDAERLYELIWRQFVACQMPPAQYLSTSVTVEAGDFELRAKGRILKFDGYTKVMPQQSKAGEDDVLPEMSKGDAMKLLKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVSLHNRRFYSEKMGDIVTERLSESFNNLMDYGFTAGMEEHLDDVAQGERDWKHVLDEFYGDFRKKLEVAESSENGMRANQPTLTDIPCKVCGRPMMIRTASTGVFLGCSGYSLPPKERCKSTVNLIPGDEIAADDEGESESRVLLGKHRCPICSTAMDAYLLDETHKLHICGNNPDCSGYEIEEGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNAECKNTRKLLKNGEPAPPKMDAVKMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVRELIPHKDEIDPKYHFLLQAPQQDPDGRPAVIRFSRKTKEQYVQSEVDGKPTGWKAFYDGGKWQVEDKR
(1732) DNA topoisomerase 1 [Pseudomonas syringae pv. syringae B728a]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASAAKDPAAKRGKAAAGEGPVLTPKEKAQRQLVSRMGVDPEHGWKAKYEILPGKEKVIEELRKLAKDADIIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSKPGELDIARVNAQQARRFLDRVVGYMVSPLLWQKVARGLSAGRVQSVAVKLVVEREREIRAFNPEEYWEIHADLGTAKGANVRFEVARENGEAFKPLNETQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAVSMARDYIGTEFGKKYLPESPNVYSSKEGAQEAHEAIRPSDVNTHPSKLTGMERDAERLYELIWRQFVACQMLPAQYLSTTVTVAASDFELRAKGRILKFDGYTRALPQMAKPGDDDVLPDMAQGETLKLNKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTGRLSESFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFRKKLEVAEAADGGMRANQPVMTDIPCKVCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLTPGDEIADDDEGESESRVLRGKHRCPICSTAMDAYLLDEKHKLHICGNNPDCTGYEIEEGTYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPDCKNTRKLLKSGDAAPPKMDPVKMPELKCDKVDDTYILRDGASGLFLAASQFPKNRETRAPLVIEIAPHKDEIDPKYHFLCEAPKKDPDGRPAVIRYSRKTKEQYVQTEVEGKPTGWRAFYDGSAWKVEDKR
(422) DNA topoisomerase [Pseudomonas syringae pv. syringae B728a]
4
MRLYLCEKPSQGKDIAAVLGAKTRGDGCIKGNGVAVTWGIGHLLETAPPDAYGEHLKNWSLDTLPILPAEWKVLVKPKTASQFKIVKQLLKQATELVIATDADREGEMIARELIEYCGYRGPIQRLWLSALNEASIRQALNTVKQGSETYPLYLSALARSRADWLIGMNFSRLFTLLGRQAGYTGVLSVGRVQTPTLRLVVDRDRDISNFIPKPFWSVEVQLWTAGQSFLAKWVADEYLVDEEGRCLDQAAAAAALAALKSSQAASTVSVDTKRGKDPAPLPFDLSTLQEVCSAKFGMGVQETLDVAQSLYETHKATTYPRTDCGYLPESMFDEVPMVLDALNRTDPSIGKTLQLIDPEQRSRAWNDKKITGPHHGIIPTLEPANLSAMSEKERKVYELIRAHFLAQFLPTHEYDRTVATFECNAVLLQAVGKRIVIPGWKVLFSASSEEEANDSGGRSQILPVLQIGTRCDVQDLHLKSLKTEPPKAYTEGTLIKAMKTIAKLVKDPRLAQKLKETTGIGTEATRAGTIQGLIDRGSLIKKGSALRATEAAFSLIDAVPPAVADPGTTAIWEQALTMIEQGTLTLDDFIARQSSWITRLVEQYKGTTLSIKVPEGPKCPLCSAKTSQRKGSSGVFWACSRYPECKGTVNIGTGKKKSPGKSAKPRAATVKSS
(655) DNA topoisomerase [Pseudomonas syringae pv. syringae B728a]
4
MRLFLCEKPSQAKDIAAALGATRRGDGCWVGANATVTWCIGHLLETAPPDAYDARYKRWVLEDLPIVPEKWKMLVKPRTASQFKAVKRLLGEATELVIATDADREGEMIARELIEHCRYRGPIQRLWLSALDDASIRKALAALKPGADTFSLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIANFVPAPYWAIDVRLLHDNQAFIAQWRAPSDACDDQDRCLNQALAQQAAQAMRAAASARLVKLRTERIREAAPLPFDLGTLQEICSKKLGLGAQETLDIAQSLYETHKVITYPRSDCGYLPNSQHGEAAGIIAALCKADPALANLSPHLDPQRRSRAWNDSKVTAHHGIIPTAAVRGVERLSGKPRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGHALRAVGKQIVEPGWKRAMPEALAPAKGREAPAPQPLPALFQGCECAVAEVILKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLTKQGKSLCAAPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVAKQAAWMSKQVSRCVGMRMSISGPASPAGVKPPWKKKRKTTTRVAKTATTDTAAKKPRRAVRPAAKA
(959) DNA topoisomerase 3 [gamma proteobacterium HdN1]
10
MKLYIAEKPSLARAIAEALPRPHNRQDSCIQLGNGDCVTWCIGHLLEQAEPDAYDAAYKKWQIAHLPILPEQWQLQPKASTRKQLSALRTLIQSADQLVHAGDPDREGQLLVDEVIHYFKVPAAKRRNMQRLLISDLNPTAVARALTQMRSNQEFTALSTSALARSRADWLYGINMTRAYTLQGQSAGYQGVLSVGRVQTPVLGLVVRRDQVIANFISVPYYEVLAHLLTPAPSETAPSLADPAHPTDSARFTARWQPSEACKPWQDDEGRVLNRALAENVARRITDQPAHVESVEKIPRKLSPPLPYSLSTLQIDAGRRYGMSAQQVLDGCQQLYERHRLITYPRSDSRHLPEDHFAQSNDVLRAIASFGEPLQSACRHANPTLRSKAWDNAKVDAHHAIIPTEKPPQTQSLSDVERKLYEQIARQYVAQFYPAHRYLETQLALRIAGGLFTASARQVQEIGWKTLYARETGHAEDTDALTEIPPLNPGDILHCERGELQEKQTRPPAHFTDASLLSAMTGVSRFVKDPEIRKILKETDGLGTEATRAGIIELLLKRGFVQREGKTLRATPTGTALIEALPESATLPDMTAQWESALEAICQQKIDYHAFIQPLIETLRTLIEQSTQTSPRSFSGLNAPKHTQRTKRKQPAQRFSKRLKSKSPASTGFSKK
(1092) DNA topoisomerase 1 [gamma proteobacterium HdN1]
9
MQKSLVIVESPAKAKTINKYLGKNFIVKSSVGHVRDLPTSGRGETATDSKQRSQKAAATRQLSAAEKEKQKKARAWEALVARMGVDPEHGWKATYQVLPDKQKVVDELRKLAKDCDSIYLATDLDREGEAIAWHLREVIGGDDSRFQRVVFNEITQSAIQEAFASPGRVNENRVNAQQARRFLDRVVGYMVSPLLWAKIGRGLSAGRVQSVAVRLLVEREREIRAFLPEEYWELFAETLTAKKTPLRLEVAREGDKAFRPTDEAQAMAAVKALQHAEYRVANREDKPTRSKASAPFITSTLQQAASTRLGFSVKRTMMLAQRLYEAGYITYMRTDSTNLSAEAVGACREYIEGRYGARYLPDAPNTYASKEGAQEAHEAIRPTDVHLMADQVSGLEKEAQKLYELIWKRFVACQMPPAEYLSTQMTVKAGEFELRAKGRILKFDGHLAVGMPGTRTSDEDIELPDVAVGEVLALKKLDPLRRFTKPPQRFTEASLVRELEKRGIGRPSTYASIISTIQERGYVRVESRRFYAEKMGDIVTDRLSESFDNLMDYGFTARMEEKLDEIAQGNLYWQNVLDEFYSRFSGQLAHAELTEGGMRSNTPVETDIPCPQCGRPMMIRTGATGVFLGCSGYNLPPKERCKGTLNLVPGEEGISATPESDEDESGELEALALRKKHRCKLCATAMDSYLVDEHRKLHVCGNNPDCPGYEVEQGQFKLKGYEGPIVECDKCGSDMQLKTGRFGKYFGCTNEECGNTRKLLRNGEVAPPRESPIPMQHLRCQKHDDFYLLRDGASGLFLAASQFPRHRETRAPTIAELKTVAEQIPEKYQYLLSAPVKDDKGNPAIVRFSRKSREQYVMSESEGKATGWSAVWADGKWVQKPAKE
(737) DNA topoisomerase 1 [Nostoc punctiforme PCC 73102]
1
MIKRLLVVESPGKVKKLSQILGSDWKVLASCGHIRELSNEGDDSLGFVMDGSNVRCNYVPRDQRAKETIQKLKSAVRQVDEVVLATDPDREGETIAWHLKETLGLKEPKRVIYTEITASAVQSAIANPKKLDQNLIGAGLCRDCLDKLVGYKGSPLVWALNNGAKSVGRVQSATLHLICQRENEILAFVPQDYWSVWVDYAEGFRAFYKGTVDSAKDAADQETETNDDAKVGNSPETPESKRVLSEAEATRLVEEAQRHPHQVIHFEGKIVNRQPPPPFTTSSLQQAAGSKLRFAPDKTMIVAQKLYEAGLITYMRTDSVMLSPEFCASARKWLEQNDPQNVPHQVAKHRSSKSAQEAHEAIRPTDVFRPSVQLRLELPDDEFNLYVMIWKRSIASQCRAAQLRKTLVITQSGSLLWSARGQVIEFYGYARYWNNLSKDSVLPSLQQGQALKLENAGHEKKQTQPPPRYSEPKLVQLMERKGIGRPSTYAPTVATLKKRNYVELKKDHLQPTALGLEVDAFLLKALPDLLEAEFTAKMEDALDAISEGKNSWQHYLTSWNQNYFIPALSKAKTVVASSPKGKANVITERKYETSKTRCPECKNFLAKIPSTKVKKKYFLKCTKGCENVVLFWSDFNKTWQPPQTKTVQVENQQKPPVKMTAYPCPVCKKPLEEYSYIKEGQSKKMLRCCDPQARKDTKHKDVAYFSTPKGWWSPKFGELGVKS
(1319) DNA topoisomerase 1 [Nostoc punctiforme PCC 73102]
1
MSTLVIVESPTKARTIRNYLPAGYRVEASMGHVRDLPQSASEIPAAVKGETWAQLGVNVDADFEPVYVVPKDKKKIVTQLKEALKDVDELILATDEDREGESISWHLYQLLKPKVPTKRMVFHEITQEAIKKALKDCRQIDEQLVRAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVTRERQRRAFHEGTYWDLKASLSKEKTPFAAQLVTLAGTKIANGSDFDATTGQITAGRNVLLLNEDQAVALKERLTGKTWSVTEMEERPVTRKPSPPFTTSTLQQESNRKLRLSARDTMRVAQNLYEQGYITYMRTDSVHLSDQAIAAARSSVEKLYGQQYLSPQPRQYTTKSKGAQEAHEAIRPAGSTFRTPQETGLGGRELAVYDLIWKRTVACQMADSCQTQISVQLQVEDAGFRSSGKRIEFPGYLRAYVEGSDDPEAALEDQEVILPNLKVGDHPNCTDLEAVGHETQPPARYTEASLVKTLESEGIGRPSTYASIIGTIIDKGYAHLVSNALIPTFTAFAVTDLLEKHFPDIVDPSFTSKMEQTLDDIATGEAKWLPYLQKFYLGEKGLETLVKERESQIDATTARTVELENLDAKVRIGKYGPYIEVTNGEGVITASIPKDLTPADLDPKQVEVLLRQKITGPDQVGRHPETGEPIYVKIGAYGPYVQLGDKTDENPKPKQASLLKGVTPETVTLEMAVGLLALPRTLGVHPVTGGKIQASLGRFGPYVVHDQGKEGKDYRSLKAADNVLTISLERALELLSEPKKGRSSTNSKSKAALRELGPHPEDGETINIYDGPYGPYIKHGKTNVSIPEGQTVEDITLTEALNLLAAKASTAKSTRKTTKSTNSKSKSTGKSTAKSTTAAKKKVTEG
(733) DNA topoisomerase 1 [Anabaena variabilis ATCC 29413]
3
MPKRLLVVESPGKVKKLSQILGSEWIVRASCGHIRELSDEGEDALGFSMDGGSVQCHYVPRDQRSKETIQQLKSAAKQVSEVVLATDPDREGETIAWHLKEVLGLREPKRVVYTEITASAVQSAIAHPRKLDLNLVGAGLCRDCLDKLVGYKGSPLVWALNNGAKSVGRVQSSTLHLICQREREIQSFVPQDYWSVWVDYVEGFRAFYKGAVNTRSDSPETEVEIHDDAAGNSTTAPESTRVLAEAEANRLVEEARRHPHQIVQYEGKIANRQPPPPFITSTLQQAAGSKLKFAPEKTMQLAQKLYEAGLITYMRTDSVMLSPEFCESARQWLEQNDPQNVPKQVARHRSSKTAQQGHEAIRPTDVFRPSAQLRIELSTDEFNLYVMIWKRAIASQCRPAQLRKTVVITQSGQILWQARGQVVEFLGYTRYWPNLSKDTLLPTLQQGQMVTLENAGHEKKQTQPPPRYSEPKLVQLMERKGIGRPSTYSPTIATLKKRGYVELTKDNLHPTNLGLEVDTFLQKALPDLLEAEFTAKMENALDAIAEGKQPWQIYLTTWNQNYFAPALAKAKTIAVDSGNPTKTFPPRQYDTSRTRCPDCNNFLSKIPSSKLKKKYFLKCTSGCENTVLFWSEFSKTWQAPRTKDDKMAENGQKNHLSPATKLPTQLTAYPCPVCKRPLEEYTYTKDGQKKTMLRCSASSSRTDKKHQDVAYFHTAKGWWSPKFGEINK
(847) DNA topoisomerase 1 [Anabaena variabilis ATCC 29413]
1
MSTLVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASEIPATVKGEAWAQLGVNVDADFEPVYVVPKDKKKVVTQLKEALKDADELILATDEDREGESISWHLYQLLKPKVPTKRMVFHEITQEAIKKALKDCRNIDEQLVRAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVNKERQRRAFREGTYWDLKAYLEQSKSPFTAQLTTLAGTKVATGSDFDASTGRITAGRNVVLLTETEAVALQERLTGKTWNVSEVEERPVTRKPAPPFTTSTLQQESNRKLRLSARDTMRIAQNLYEQGYITYMRTDSVHLSEQAIAAARNCVEQLYGKQYLSPQPRQYTTKSKGAQEAHEAIRPAGSTFRTPQETGLGGRELALYDLIWKRTVASQMADSRQTQITVQLQVEDAGFRASGKRIDFPGYLRAYVEGSDDPEAALEDQEVILPSLKVGDHPDCKNIEAVGHETQPPARYTEATLVKTLESEGIGRPSTYASIIGTIIDKGYSQLVNNALIPTFTAFAVTDLLEKHFPDIVDPSFTSKMEQTLDDIAEGEAQWLPYLKKFYLGDQGLETLVRERESQIDAGKARTVELENLDAKVRIGKYGPYIEVENGDGVVTASIPKDLTPADLDPKQVEIILRQKTVGPDQLGRHPETGEPIYVKIGAYGPYVQLGDKSDENPKPKQASLPKGVTPENISLETAIGLLSLPRTLGTHPATGGKIQASLGRFGPYVVHDQGKEGKDYRSLKASDDVLTISLERALELISEPKKTRGSTSSKSKAALRELGTHPEDDAPINIYDGPYGPYIKHGKTNVGLPEGTSVEDVTLATALELLSAKASTAKTTRKTSKTSTTKSKSTAKSSSTATKKKGA
(1649) DNA topoisomerase 1 ['Nostoc azollae' 0708]
1
MSTLVIVESPTKARTIRNYLPQDYRVEASMGHVRDLPQSASEIPAAVKGEKWAQLGVNIEADFEAVYVVPKDKKKIVTQLKDALKGVDELILATDEDREGESISWHLYQLLKPKIPTKRMVFHEITQEAIKKALQNCRIIDEQLVRAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLLVTKERQRRAFHEGTYWDLKASLLQEKTPFRAQLVTLGGTKVATGSDFDPATGQITAGHNVVLLNKEQAVELQEQLTGKTWNVNNIEERPVTRKPAPPFTTSTLQQESNRKLCLSARDTMRVAQNLYEQGYITYMRTDSVHLSDQAIAAARSCVEKKYGKQYLSPQPRQYTTKSKGAQEAHEAIRPAGSTFRTPQETGLGGREFAVYDLIWKRTVASQMPDSRQTQITVQLQVEEASFRSSGKRIDFPGYLRAYVEGSDDPEAALEDQEVILPPLKVGDHPTCTELEAVDHETQPPARYTEASLVKTLESEGIGRPSTYASIIGTIIDKGYAHLVSNALIPTFTAFAVTDLLEKHFPDIVDPSFTSKMEQTLDDIATGEAKWLPYLKKFYLGEKGLETLVRERESQIDATTARTVELENLDAKVRIGKYGPYIEVENGEGVVTASIPKDLTPADLDPKQVEVLLRQKTTGPDQVGRHPETGEPIYVKIGTYGPYVQLGDKTDENPKAKQVSLPKGVTAENLTLDMAVGLLALPRTLGVHPATNSRIQASLGRFGPYVVHDQGKEGKDYRSLKAVDNVLTISLERALELLAEPKKGRASSTSKSKAALRELGTHPEDDSPINIYDGPYGPYIKHGKTNVSLPEGQTVETVTLSAALELLQAKASTKSTTRKTTKSTSSKTKSTTKSSMSRAKKKEASN
(1849) DNA topoisomerase 1 [Thioalkalimicrobium cyclicum ALM1]
1
MKNLVIVESPAKAKTIEQYLGKDFVVRSSYGHIRDLSKKGMGIDIPNRFLPSYEVSPDKKKTVTELRKLAKEADAVWLATDEDREGEAIAWHLAEALNLNVAETKRIVFHEITKPAITQAVANPRQVDLNLVNAQQARRILDRVVGFELSPILWKKIRTGLSAGRVQSVAVRLIVEREREIDAFTPVSSFKVSGELYTLNAQGQPDEMLPVKRLAAFDDEASAQAYLASLTGATFSVAQLDQKPAKRSPKPPFTTSTLQQEASQKLGFSVKQTMVIAQRLYESGKITYMRTDSVNLSEVAIGQAKDVITKRFGANYSHPRRYKTKQADAQEAHEAIRPTDFSVTEVGGERNEQRLYQLIWARALASQMSEAELLRSQVDIAIAPSNNELLVAKGEVVTFEGFMKVYNLDGQKDQDVLLPALKVGQNLQPVLLQAKQSFSRAPARYNEASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVIKEDREGSPRAVRLLSWQAGQVKAETLEEITGSEKNKLFPTDIAGIVNDFLVKNFGQVLDFQFTAQVEAKFDQIAMGQQAWQDMLEDFYHKFHPNVELAETLSREEAGQARLLGNDPKTGKPMLVKIGRFGPFVQLGDGENDEKPTFASLKPGQKMDTIKLEEALELFKLPRVLGDMPEAYHAAAADGTPFGVEQGQTITAKQGPFGPYLEYGEKQFAPIKGYDPLSITLEEAVLVIEAKIQADADKIVRSFPSTDVKILKGRWGPYITDTVTKVNAKIAKDEDPMELTLEECQTRLAAAPPPKKRGRAAAAKKPAAKRAPAKKTTTKKVTAKK
(955) DNA topoisomerase 3 [Erwinia amylovora CFBP1430]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGSDQVVTWCVGHLLEQAQPDSYNGRFARWSLADLPIVPEKWRLQPRPSVAKQLNVIKGLLSQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKHAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVAKDFFEVRAHIVTPADERFVALWQPSDSCEPYQDDEGRLLHRPLAEHVVARIGGQPAHVTSYNDKRENETAPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRHLPDEHFAGRHAVLNAINIHLPNLTPPGDFNSDQKNRCWDDKKVDAHHAIIPTARSSQVALSDHERQIYCLIATQYLMQFCPDAIYRKCVIELAIAGGKFLAKARFLAEAGWRALLGSKERDEENDGTPLPVVTRGDELLCERGEVLEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRSFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMSPLVETLHSLIQQARQQPAAYAFRGLPAPATDKTKRPRRKTAQKKESET
(568) DNA topoisomerase 1 [Erwinia amylovora CFBP1430]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGTTVKKSTDSTTSKPTKKVKKDEKTALVNRMGVDPFHGWAANYQILPGKEKVVSELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIRHAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELNADLTTPKGVDLPMQVTHQHDKPFRPINRDQTYAAVSLLEKARYVVVDREDKPTGSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMARGYIEEEFGAKYLPKTANLYSSKENSQEAHEAIRPSDVKVQSEQLKDMETDAQKLYQLIWRQFVACQMMPAQFDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDDRTLPAVEVGSELSLQQLLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNQAQWKAVLDKFFGDFSQQLEQAEKDPEEGGMQPNQMVVTSIECPSCSRQMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCGKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEQGEFRIKGYDGPVVECEKCGGEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPRVEELQRFRDRLPEKLRYLADAPAEDAEGNKAVVRFSRKNKQQYVSTEKEGKATGWSAFYVDGKWEVAKK
(79) DNA topoisomerase 1 [Erwinia tasmaniensis]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPISGSTVKKSTDSTTSKTTKKVKKDAKTALVSRMGVDPFHHWEANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIHQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWDLNADLTTPKGIDLPMQVTHQHDKPFRPVNRDQTYAAVSVLENARFTVVDREDKPTSSKPGAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVSMVRGYVEDEFGAKYLPKTANIYSSKENSQEAHEAIRPSDVKIQSEQLKDMEADAQKLYQLIWRQFVACQMMPAQYDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDERTLPAVEVGSELSLQQLLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNEAQWKTVLDKFFGEFSQQLEQAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCDKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEQGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEDCKNTRKILRNGDVAPPKEDPVPLPELVCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPQVEELQRFRDRLPEKLRYLADAPAEDADGNKSVVRFSRKTKQQYVSTEKDGKATGWSAFFVDGKWEVAAKK
(1269) DNA topoisomerase 3 [Erwinia tasmaniensis]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGGDQVVTWCVGHLLEQAQPDSYNSRFARWSLADLPIVPEKWRLQPRPSVAKQLNVIKGLLEQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKRAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVAKDFFEVRAHIVTPADERFVALWQPSDSCEPYQDEEGRLLHRPLAEHVVARINGQPAHVTSYNDKRENDTPPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINLHQPDLSAPTDFNSDQKNRCWDDKKVDAHHAIIPTARSGQVRLTDNEGQIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFLAKARFLAEAGWRALLGSKERDEENDGTPLPVVAKGDALLCERGEVLEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAQWESTLTKISEKQCRYQDFMSPLVETLHSLIHQARQQPAAHAFRGLPPPASDKVKKTRRKTTKKKESEA
(517) DNA topoisomerase [Erwinia sp. Ejp617]
4
MRLFICEKPSQGRDLAAVLGATQRGDGFLAGSGITVTWAVGHLLETAPPEAYGQQYGKPWTLAALPIIPSPWQVVVKKETQHQFKIIERLLRQVDEVIIATDADREGEVIARELLDYCRWEGPVQRLWLSSLDELSIRAALQNLRPGGETLGMYHAGLGRARADWLTGMNLSRLYTLRAAEAGFDGVVSVGRVQSPTLALVVRRDREIAAFVPKPYWQVKAQLSAGGITFPAQWVPAKVYTDEEKRCIHQNIAQQVVQICRQSGEATVTECETKREKASPPLAFSLGTLQQAASRLWDMSPQQVLDTAQSLYEKHKATSYPRTDCGYLPESMREEIPALLDAIGRTDPECLPLLSQLDASLVSRIWNDKKITAHHGIIPTRNAFQLSALSETERQVYMLIRRNYLAQFLPLHESDITRLAFDIGGQLFRTTGRTEVVKGWKVLFGKAEEEGSAADDEAVVALPPLKKDDRCGVTGAEVVQLMTRPPAHYTFATLIGAMMNAAAFVTDVALRKVLKDNAGLGTEATRAGIVEQLLNRRFIVRKSSKLLATDLGSDVIDSLPPQLTEPGMTALWEQALDEVAAGRMSLSDFLQRQTGWTRNLVSQGAQQQVSIRIPPTPPCPLCGGKTRLRKGQKGDFWSCQRYPDCKGVINIGSGKRKSPRKAKSPKPNKN
(407) DNA topoisomerase 3 [Erwinia sp. Ejp617]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGSDQVVTWCVGHLLEQAQPDSYNSRFARWSLDDLPIVPEKWRLQPRPSVAKQLNVIKGLLTQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKRAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVAKDFFEVRAHIVTPADERFVALWQPSASCEPYQDEEGRLLHRPLAEHVVARIGGQPAHVTSYNDKRENETAPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINVHQPNLSPPGDFNSDQKNRCWDDKKVDAHHAIIPTARSSQVSLSDNEQQIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFVAKARFLAEAGWRALLGSKERDEENDGTPLPVVTKGDELLCERGEVQEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMSPLVDTLHSLIQQARQQPAAHAFRGLPASATDKTKRPRRKTAQKKESET
(377) DNA topoisomerase 1 [Erwinia sp. Ejp617]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTVKKSADSTTSKTTKKVKKDEKTALVNRMGVDPFHGWEANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIRQAFDRPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVDREREIKAFVPEEYWELNADLTTPKGVDLPMQVTHQHDKPFRPINREQTYAAVSLLEKARYVVVDREDKPTGSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMVRGYVEEEFGAKYLPKTANLYSSKENSQEAHEAIRPSDVKVQSEQLKDMEADAQKLYQLIWRQFVACQMVPAQFDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDDRTLPAVEVGSELSLQQLLPGQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNEAQWKAVLDQFFGDFSQQLEQAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALSPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCGKCGTAMDSYLIDNQRKLHVCGNNPECDGYDIEQGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPQVEELQRFRDRLPEKLRYLADAPAKDADGNKAVVRFSRKTKQQYVSTEKDGKASGWSAFYVDGKWEVTKK
(437) DNA topoisomerase 1 [Moraxella catarrhalis RH4]
9
MATSKKTTTKAEAALTKANARGKSLVIVESPAKAKTINKYLGKDYVVRSSVGHVRDLPVGGSATKTNKTQDVGLSREEKAQKALVRRMGVDPEHDWAAVYEILPNKTKVIRELKALAKEADKIYLATDLDREGEAIAWHLKEVIGGSDDKYSRVVFNEITKTAIQTAFEHPDQLNIDRVNAQQARRFLDRVVGFMVSPLLWAKIARGLSAGRVQSVATRLVVEREREIRAFVPVEYWKIHTNNTAAGETLNLEAVKKNGKTLKLGNKAQADEVVLALGSSDFIVSAIEEKPTQSRPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSQDALNLVREYITDHFGDDYLPQKPNFYGNKQNAQEAHEAIRPSHVLVKSSQLTGMERDAQRLYELIWRQFVACQMMPARYQSVNLMVAAGDIELKAKGRTLVFDGYTKVQPPAKTDDILLPAVKVGEKLPLIEILPTQHFTSPPARYSEASLVKELESLGIGRPSTYASIISTIQERGYVKLENKRLYAEKMGDIVTERLVESFPDLMDYAFTAGLEDKLDEVAVGEEDWKTVLDRFYHDFKQKLDYAKTTDGMRPNNPTNVPDIHCDLCHRPMQIRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVSAFEFDADDDSAEVNALMEKKRCPKCNTAMDGYIVDGGLKLHICGNNPDCDGHVLEKGVFEIGGATSDTPTIDCDKCDGQMELKTGRFGAYFACRKCDNTRKVLKNGQAAPPRMTPIDMPKLRSQKFDDHYVLREGAAGLFLAASKFPKVRETRPPKLSELREIKDQLEPKFYYLFDAPDTDDVGNPTILRWSRKNQEQYVGSEKDGKATRFALVWRDGAWVQA
(438) DNA topoisomerase 1 [Moraxella catarrhalis RH4]
9
MATSKKTTTKAEAALTKANARGKSLVIVESPAKAKTINKYLGKDYVVRSSVGHVRDLPVGGSATKTNKTQDVGLSREEKAQKALVRRMGVDPEHDWAAVYEILPNKTKVIRELKALAKEADKIYLATDLDREGEAIAWHLKEVIGGSDDKYSRVVFNEITKTAIQTAFEHPDQLNIDRVNAQQARRFLDRVVGFMVSPLLWAKIARGLSAGRVQSVATRLVVEREREIRAFVPVEYWKIHTNNTAAGETLNLEAVKKNGKTLKLGNKAQADEVVLALGSSDFIVSAIEEKPTQSRPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSQDALNLVREYITDHFGDDYLPQKPNFYGNKQNAQEAHEAIRPSHVLVKSSQLTGMERDAQRLYELIWRQFVACQMMPARYQSVNLMVAAGDIELKAKGRTLVFDGYTKVQPPAKTDDILLPAVKVGEKLPLIEILPTQHFTSPPARYSEASLVKELESLGIGRPSTYASIISTIQERGYVKLENKRLYAEKMGDIVTERLVESFPDLMDYAFTAGLEDKLDEVAVGEEDWKTVLDRFYHDFKQKLDYAKTTDGMRPNNPTNVPDIHCDLCHRPMQIRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVSAFEFDADDDSAEVNALMEKKRCPKCNTAMDGYIVDGGLKLHICGNNPDCDGHVLEKGVFEIGGATSDTPTIDCDKCDGQMELKTGRFGAYFACRKCDNTRKVLKNGQAAPPRMTPIDMPKLRSQKFDDHYVLREGAAGLFLAASKFPKVRETRPPKLSELREIKDQLEPKFYYLFDAPDTDDVGNPTILRWSRKNQEQYVGSEKDGKATRFALVWRDGAWVQA
(203) DNA topoisomerase 1 [Psychrobacter sp. PRwf-1]
9
MAKTTAKKTTSTPAASAKGKSLVIVESPAKAKTINKYLGDDFIVRSSIGHVRDLPTSSGVKKKATKTDEKLSKEDKAQQALVRRMGIDPEHGWKAVYEVLPNKTKVIKELKALAKDADKIYLATDLDREGEAIAWHLREVIGGDDSKYQRVVFNEITKSAIQNAFKEPGKLDIDRVNAQQARRFLDRVVGFMVSPLLWQKIARGLSAGRVQSVATRLVVEREREIRAFIPEEYWQIHADTTMKGSENANVAADTPIRLEAVKQAGKVLKLGNKAQTDAVLAVLKPATFVVKEREEKPTQSKPSAPFITSTLQQAASTRLGFPVKKTMMLAQRLYEAGHITYMRTDSTFLSNDALASVRGFIEENYGSKYLPEKPNFYGSKQNAQEAHEAIRPTNANLKSTQLKGVDRDAIRLYELIWRQFVACQMLPAKYKSVNLLVEAGDVELKARGRTMTFDGFTKVMPPAKTDDTLLPDVKQGDELNLIKLDPSQHFTKPPARYTEASLVKELEKKGIGRPSTYASIISTIQDRGYVRLENKRLYAEKMGDIVTDRLTESFPELMDYTFTAGLEDELDHVAQGDQDWKAVLDDFYGDFKTKLEHAKDKDGMRPNDPTDVPDVHCDLCGRPMQLRNGSTGVFLGCTGYNLPPKERCKGTKNLMPVEAFANLDDSEIDESAEVKELMEKKRCPKCSTAMDGYIVDGGLKLHICGNNPDCDGYLLEEGMFEVPGSDAPTIDCNKCDGQMELKTGRFGPYFACNKCDNTRKVLKNGEPAPPRMDPIDMPELKSTKHEDHFILREGAAGLFLAASKFPKVRETRPPKLSELRTIKDKMDDKFQYLFDGPDQDPEGNPTILRWSRKQKEQYIGSESLKTGKATRWGVYWRKGEWVEE
(826) DNA topoisomerase 1 [Psychrobacter cryohalolentis K5]
9
MTKPAAKKSAAPAADKPKGSPKASPKGKSLVIVESPAKAKTINKYLGDDFIVRSSIGHVRDLPVGASKSAKKPATTKKDDSLSKEEKTQQALVRRMGVDPEHDWAAVYEVLPNKTKVIKELKALAKDADKIYLATDMDREGEAIAWHLKEVIGGADSKYERVVFNEITKSAIQNAFKQPSKLDIDRVNAQQARRFLDRVVGFMVSPLLWQKVARGLSAGRVQSVAMRLVVEREHEIRAFIPEEYWQIHADTHIADSKAKKAADAEQIGIRLEATKQGGKTLKLVNKEQTDKVLDVLKANDFIVKEREEKPTQSKPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSGDALAAVRGYIEDSYGAKYVPEKPNFYGNKQGAQEAHEAIRPSNVNMKSTQLKAVERDAIRLYELIWRQFVACQMLPAKYLSVNLFVAADDVELKARGRTLVFDGFTKVMPPAKTDDNLLPDVKKGDKLILDKLDPSQHFTKPPPRFTEASLVKELEKKGIGRPSTYASIISTIQDRGYVKLENKRLFAEKMGDIVTDRLTASFPDLMDYTFTAALEDKLDHVAEGDTDWKDVLDNFYGDFKTTLDRAKEKDGMRPNDPTDVPDVHCDLCARPMQLRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVEAFANLDDAEGDDEAAEVRDLMEKKRCPKCGTAMNGYIVDGGLKLHVCGNNPDCDGYVLEEGKFEVPGSDSPTIDCNKCDGQMELKTGRFGPYFACQQCDNTRKVLKTGEAAPPRMDPIHLPELKSVKHEDYFILREGAAGMFLAASKFPKVRETRPPKLAELREIKDKMEDKFQYLFEGPDEDPDGNPTILRWSRKKKEQYIGSEKNGKATRWGVYWRKGEWVEE
(1437) DNA topoisomerase 1 [Francisella sp. TX077308]
1
MAKNLVIVESPAKTKTIKKYLGNNFDILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKSAKNAENIYLATDPDREGEAISWHVQEVLKNARLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVNAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFVKKDYWSLTADIFKQKQIFANLTEFDGTKVEQFTFTAEKDAENAKATITKDANGFLIVEGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGMDLGNGESVGLISYMRTDSTNLSNDALNDIRSFIESKFDKDMLPSKPRVFGKKSQNAQEAHEAIRVTSASKTPESMKPYLTTDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENEKHKFRVTGTVIVDAGFLKIYNVEKDEDEKESNDEQTLPKFEKGEKVPLKDIITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQRDYAEVEKRRFIPTDKGRVVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLTVLNSFWKPFIERINKIAEDVSRKDVVQEELDEDCPECGSKLSSRLGKNGRFIGCTNYPTCKYTRRVDSDGKEIEKEEPTVVEDRKCPECGSNLHIKQGRYGKFIGCSNYPTCKHMEPLEKPKDTGVVCPKCNKNNIVEKKSRKGKVFYACSGFPKCKNAYWYPPIKEECPKCKSPILLHKTTKKDGEQKACPNPECDYAVPWEENK
(1698) DNA topoisomerase 3 [Enterobacter aerogenes KCTC 2190]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDGRYARWNLLDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQDERFIATWVPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPAIVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAISVHAPDLLPQPVMDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLNDNEEKVYNLIARQYLMQFCPDAVFRKCQIDLDIANGKFVAKARFLAEAGWRALLGNKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRGFLNKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFQLIDQARSTPVRQFRGLVAPGGAKKSFSKGKGKPKGKKPEADIAPESPQ
(1358) DNA topoisomerase 1 [Enterobacter aerogenes KCTC 2190]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERGALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPGGDALPLQVTHKNDKPFRPVNRDETMAAVALLEKALYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGDNFGKKYLPENANQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGEFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPVVNQGDNLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRAENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKQVLDNFFGDFTSQLQTAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFFIDGKWTEAKK
(862) DNA topoisomerase 1 [Acinetobacter oleivorans DR1]
9
MANTSRSASQSTASTAPAAHKRALVIVESPAKAKTINKYLGSQFIVKSSVGHVRDLPTGGSKSTEKKPAARTKLTEAEKEQKASQALVNRMGVDPEHGWEAHYEVLPGKENVVAELKKLAKDADAIYLATDLDREGEAIAWHLREVIGGDDSRYHRVVFNEITKNAIQEAFKQPTRLDLNRVNAQQARRFLDRVVGFMVSPLLWEKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWQVFADTQAKKDDIRLEAFRQAGKTLKLKNKAETDALLDVLKGAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEAGFITYMRTDSTFLSDDAVSMVRAHIESQYGEKYLPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGVERDAQRLYDLIWRQFVACQMTPAEYLSSTLIVEAANVELKAKGRTLVFEGFTKVRGANKSDDDIILPAIKVGEILKLEKLDPSQHFTKPPARFTEASLVKELEKRSIGRPSTYAAIISTIQERGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDKVATGERNWKELLDTFYGDFKKRLTNAQGEHGMRRNQPVEVPAVHCPECSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAALSDDDGAETADLMSKHRCAKCGTAMDSYVIDGGRKLHVCGNNPDCDGFELEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKSGQPAPPRVEPIKMEHLRSAKHDDFFVLRDGAAGLFLAASKFPKIRETRAPKVAELRSVAAQLDPKYQFILQAPDVDPEGNPTIVKFSRKNQSQYVGSETPEGKQTKWSLVYQDGKWVEG
(717) DNA topoisomerase 3 [Klebsiella variicola At-22]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLTDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVATWVPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPALVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADLLPQPVMDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLTDNEAKVYHLIARQYLMQFCPDAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFQLIDQARSTPVRQFRGLAAPGGAKKSFSKGKGKPKGKKAADDAAPPPQ
(972) DNA topoisomerase 1 [Klebsiella variicola At-22]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSTDSTATKGAKKPKKDERGALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVIHKDDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDNFGKKYLPESANQYASKENSQEAHEAIRPSDVSVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPVVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLETAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVASEKEGKATGWSAFFIDDKWTEAKK
(160) DNA topoisomerase 1 [Acinetobacter sp. ADP1]
9
MANAPRSTTKKSTTASSEPAGNKRALVIVESPAKAKTINKYLGSQYIVKSSVGHVRDLPTGGSAKSGEKKPATRAKLTAEEKEQKAQNALINRMGVDPEHDWKAHYEVLPGKEHVVAELKKLASQVDEVYLATDLDREGEAIAWHLKEVIGGDDSRYQRVVFNEITKNAIQEAFKHPARLDTNKVNAQQARRFLDRVVGFMISPLLWEKIARGLSAGRVQSVAVKLVVERERDIRAFIPEEYWQIFADTLSKKDQIRLEAVKQAGKTLKLRNKADTDAVLNLLKDAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEGGFITYMRTDSTFLSDDAVNMVRDHIQQQFGDKYVPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGMERDAQRLYDLIWRQFVACQMTPAEYLSSTLIVDANNVELRAKGRTLVFDGFTRVRGANKSDDDVLLPAVKVGETLKLEKLDPSQHFTKPPARFTEASLVKELEKRGIGRPSTYAAIISTIQDRGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDKVATGERNWKELLDSFYGDFKNRLNMAASTEGMRRNQPVEVPDVACQLCSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAAFSDDDSAETADLMAKHRCAKCGTAMDSYVIDGGRKLHVCGNNPDCDGYEVEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKSGQPAPPRVDPIKMEHLRSVKHDDYFVLRDGAAGLFLAASKFPKIRETRAPKVAELRTVAEQLDPKYQYLLQAPDADPEGNPALIKFSRKNQAQYVGSETPEGKQTKWSLVYQDGKWTEA
(1489) DNA topoisomerase 1 [Acinetobacter baumannii ATCC 17978]
9
MANTSRSASQSTASSASAAHKRALVIVESPAKAKTINKYLGSQYIVKSSVGHVRDLPTGGSKATEKKPAARTKLTEAEKEQKANQALINRMGVDPEHGWQAHYEVLPGKENVVAELKKLAKDADAIYLATDLDREGEAIAWHLREVIGGDDSRYHRVVFNEITKNAIQEAFKQPTRLDLNRVNAQQARRFLDRVVGFMVSPLLWEKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWQVFADTKAKKDDIRLEAVKQAGKTLKLKNKAETDALLDVLKGAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEAGFITYMRTDSTFLSDDAVSMVRAHIESQYGEKYLPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGVERDAQRLYDLIWRQFVACQMTPAEYLSSTLTVEAGNVELKAKGRTLVFDGFTKVRGANKSDDDIILPAIKVGEILKLEKLDPSQHFTKPPARFTEASLVKELEKRGIGRPSTYAAIISTIQERGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDRVATGERNWKELLDTFYGDFKKRLTNAQGEQGMRRNQPVEVPAVHCPECSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAALSDDDSAETADLMSKHRCPKCGTAMDSYVIDGGRKLHVCGNNPDCDGYELEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKNGQPAPPRVEPIKMEHLRSTKHDDYFVLRDGAAGLFLAASKFPKIRETRAPKVAELRSVADQLDPKYQFILQAPDVDPEGNPTIVKFSRKNQSQYVGSETPEGKQTKWSLIYQDGKWIEG
(1590) DNA topoisomerase 3 [Klebsiella pneumoniae KCTC 2242]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDIYDSRYARWNLNDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVATWVPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPAIVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADLLPQPVVDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLTDNEAKVYTLIARQYLMQFCPDAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCERGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLSKKGRYIHSSEAGRALIHSLPEMAGRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQARSTPVRQFRGLVAPGGAKKSFSKGKGKPKGKKAADDTAPPPQ
(730) DNA topoisomerase 1 [Klebsiella pneumoniae KCTC 2242]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTATKGAKKPKKDERSALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVTHKDDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASKENSQEAHEAIRPSDVNVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLATAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVASEKEGKATGWSAFFIDGKWTEAKK
(1417) DNA topoisomerase 3 [Enterobacter asburiae LF7a]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLNDLPIVPEKWRLQPRPSVTKQLNVIKRFLHEASEVIHAGDPDREGQLLVDEVLDYLELAPEKRQQVQRCLINDLNPQAVERAISRLRANSEFIPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPKEERFTATWQPSDACESYQDEEGRLLHRPLADHVVNRITGQPAIVTSYNDKRESEPAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHYAGRHSVMNAIGVHAPDLLPQPAVNPDTRNRCWDDKKVDAHHAIIPTARTSNVNLTENESKVYNLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLEKKGRYIHSTEPGRALIHSLPELAARPDMTAHWESILTQISEKQCRYQDFMQPLVGTLYQLIDQARSTPVKTFRGMVAPGGGAKKPFKKKKSAA
(1116) DNA topoisomerase 1 [Enterobacter asburiae LF7a]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERSALVNRMGVNPWHNWDAQYEVLPGKEKVVNELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDANVTTPGGDALPLQVSHQNDKPFRPENREQTMAAVALLEKARYQVLEREDKPTSSKPGAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESANQFASKENSQEAHEAIRPSDVSVLAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDELSLVDLVPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEANFRELMNYDFTAQMEDSLDQVASHQAEWKKVLDSFFSDFTNQLDKAEKDPEEGGMLPNQMVLTSIDCPTCGRKMGIRTATTGVFLGCSGYALSPKERCKTTINLVPENEVLNILEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKEGKATGWSAFFVDGKWAEGKK
(1591) DNA topoisomerase 3 [Enterobacter lignolyticus SCF1]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLTDLPIVPEKWQLQPRPSVTKQLNVIKRLLQDASEVIHAGDPDREGQLLVDEVLDYLNLAADKRQQVQRCLINDLNPQAVERAISRLRANSEFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPADERFTALWQPSEACEPYQDEEGRLLHRPLADHVVSRISGQPAMVTAYNDKRESEPAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRQAVLNAISVHAPDLLPQPAVDPEVRNRCWDDKKVDAHHAIIPTARSSSVKLSDNEANVYGLVARQYLMQFCADAVYRKCQIDLDIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVEKGAELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLVKKGRYIHSTEAGRALIHSLPEMAGRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFSLIDQARRTPVKQFRGLVAPGGDKKKTFARKGGKRKTAAE
(755) DNA topoisomerase 1 [Enterobacter lignolyticus SCF1]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSATKKSADSASTKTAKKPKKDERGALVNRMGVDPWHDWKAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFVDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPSGEVLPLQVSHYLDKPFRPVTRDETMAAVSLLEKARYSVVEREDKPTSSKPGAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALNMVRGYISDSFGKKYLPESANQYASKENSQEAHEAIRPSDVNVMAEALKDMETDAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDYKLKARGRTLRFDGWTKVMPALRKGDEDRTLPPVKQGDALSLVELQPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKEVLNDFFGDFTRQLETAEKGPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCAKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELHRFRDRLPEKLRYLADAPQEDGQGNKTMVRFSRKTKQQYVASEKDGKATGWSAFFVDGKWQEAKK
(947) DNA topoisomerase 1 [Enterobacter sp. 638]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSASKKSADSTSTKGAKKPKKDERSALVNRMGVDPWHEWEAQYEVLPGKEKVVNELKQLAEKADHIYLATDLDREGEAIAWHLREIIGGDETRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANVTTPAGDALPLQVTHENDKPFRPVNRDHTMAAVAQLEKARYQVVEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVTMVRDYIGENFGKKYLPESANQYASKENSQEAHEAIRPSDVSVVSESLKDMETDAQKLYQLIWRQFVACQMNPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPPVNKGDELSLTELLPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRAENRRFYAEKMGEIVTDRLEANFRELMNYDFTAQMEDRLDQVANHQAEWKNVLDSFFSDFTEQLAKAEKDPEEGGMQPNQMVLTSIDCPTCSRQMGIRTATTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLRMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPLQDPEGNKTVVRFSRKTKQQYVSAEKEGKATGWSAFFIDGKWVEGKK
(224) DNA topoisomerase 3 [Enterobacter sp. 638]
10
MRLYIAEKPSLARAIADVLPKPHRKGDGFIECGKGQVVTWCIGHLLEQAQPDVYDSRYARWNLNDLPIVPEKWRLQPRPSVTKQLNVIKRFLHDAAEIVHAGDPDREGQLLVDEVLDYLELAPEKRKQVQRCLINDLNPQAVERAISRLRSNNEFIPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPKDERFVAVWQPSEACEPYQDEEGRLLHRPLAEHVVNRIAGQPAIVTSYNDKRESEPAPLPFSLSALQIEAGKRYGMSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIGVHTPDLLPQPAVNLETRNRCWDDKKVDAHHAIIPTARASNVNLTENESKVYQLVARQYLMQFCADAMFRKCVIELEIAKAKFVAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKNDELLCEKGEVIERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLIKKGRYIQSTDPGRALIHSLPELAARPDMTAHWESILTKISEKECRYQDFMQPLVGTLFDLINQARTTPVKNFRGMVAPGGAKKPFKKKKSAA
(1627) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhi]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLSVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(150) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(148) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(1628) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhi]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLSVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(149) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(94) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(1228) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(196) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Newport str. SL254]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(1239) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Newport str. SL254]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFMLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1332) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
10
MANWSRPAAVALWLRFVNLMRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAKETGRQTE
(896) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQLLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(500) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
7
MDLYICEKPSQAKDLAGVMKASQRGDGFIHDGGNRVITWAFGHLLELYMPDDYDERYKSWSLETLPIAPDAWRYNVRKSALKQYKIVEGLVKKASTIYISTDFDREGEAIARSLLDQFRYSGPIRRVCLTALDESSIKKALNNVKDGKETVSLYYAALARQRADWLVGMNVSRLYTVLARDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEECSDEQGRCINKAYAEQVSSQVNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGYTAQQVLDAAQALYETHKATTYPRTDSRYLPESQKENIPDILQALILSDQNVSGLVAGADPHRKARVFNDSKVTAHHAIIPTPARTDISAMSEIELNLYDAIRRFYIAQFYSEFEFTKTSIEVQCGRHLFAASGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALLNGTELMNKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGTVDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVATGSGNMSVFMKQISTWICQMVDQLKVAAPVLTKEGSAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQNEACKKTFPDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTMPFKKSDL
(316) DNA topoisomerase 3 [Xenorhabdus nematophila ATCC 19061]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIECGNNQFVTWCVGHLLEQAEPDAYDSRYARWVLTDLPIIPEKWQLKPRPAVAKQLNTIKSLLERASEIVHAGDPDREGQLLVDEVLDFLDLDAEKKQNVQRCLINDLNPQAVIKAVERLRNNREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFVPKDFFEVKAHIVTPSEERFTAIWQPSESCIDFQDEEGRIIHRPLAEHVVARITGQPAIVTAYQDKRESETAPLPFSLSSLQIEAAKRYGLSAQDVLDICQRLYETHKLITYPRSDSRYLPEEHFTGRHAVLNAISVHAAHLLPQDALDTERKNRCWDDKKVDAHHAIVPTARSSQVNLTKNENDIYSLIARQYLMQFFPDAIFRKCTIELDIAGGKFIAKARFLAEAGWRTLLGHKERDEENEGTPLPIVAKGDELLCEKGEMVERQTQPPRPFTDATLLSAMTGIARFVQDKALKKVLRATDGLGTEATRAGIIELLFRREFLYKKGRHIHATPAGRALIHVLPDMAVLPDMTAHWESRLTQISEKQFRYQDFMSPLQETLQQLIRQAKQYRNLKAFRDLPPVPAKGKKGKQLKSSKSKNR
(549) DNA topoisomerase 1 [Xenorhabdus nematophila ATCC 19061]
9
MAKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGAASQKSSISSTDKNKKKVKKDEKTALVSRMGVDPYHDWEANYQILPGKEKVVAELKTLAEKAEHVYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAITQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWQLHADLVAKGEIALRMEVTHEKGKPFKPVNAQQTHAAVSLLEKAKYSVIDREDRPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALDMARGYISTHFGDKYLPKEGNVYSSKENSQEAHEAIRPSNVEVMAEELKDMEADAQKLYQLIWRQFIACQMMPAKYDSTTLTVQAGNFELRAKGRTLRFDGWTKVMPVLRKGDEDNTLPAIEANTELDLQQLFPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVHVENRRFYAEKMGEIVNDRLEENFNELMSYDFTARMEDQLDHVANNEANWKGVLDEFFSNFSEQLDVASKEPDEGGMRPNPMVITSIDCPTCCRAMGIRTATTGVFLGCSGYALSPKERCKQTINLIPENEILNILEGDDAETNALRARRRCKKCGTAMDSYLIDNQRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGSEMHLKMGRFGKYMGCTNEECKNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLHYLAEAPVADPEGNKTVVRFSRKTKQQYVSSEKNGKATGWAAFFVEGSWAVKEK
(1543) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGGSITVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILPGEQTESLWQAGLGRARADWLTGINLTRLYTLKAQEQGFGEVLSIGRVQTPTLALVVNRDNDIARFEQKPYWQVMATLQKDDISFRAKWLPAPDDGDEEKRCIREDIAQRVVQRCQQAQDAVVTELTQKREKTPPPLCFDLGTLQQVASRQWGMGAGQVLTIAQSLYETHKATTYPRTDCGYLPVSMRENIPAVFTALTRTDPAMSAIISQLDASAFSRVWNDSQITAHPAIIPTRHTFDMTKLTADELKVYQLIRHYYLAQFLPAQETDVTDVTFTIGGQVFQAKGRVSVVTGWKALFADEKQAQEQEDNTALPALKKEEISPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRESAGLGTEATRAGIIEALFKRRLLARKKKNLHATQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRRGNSPD
(1717) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
4
MQLYLCEKPSQARDIARVLGVKQRGQGYLFGDSIIVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCHFTGPVRRLWLSALDETSIRQALAAILPGEKTAPLWQAGLGRARADWLTGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMATLQKDDISFRAKWLPAPDDGDEEKRCIREDIAQSVVQRCQQTQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYETHKATTYPRTDCGYLPVSMRENIPAVFTALTRTDPAMSAIISQLDASAFSRVWNDSQITAHPAIIPTRHTFDMTKLTADELKVYQLIRHYYLAQFLPAQETDVTDVTFTIGGQVFQAKGRVSVVTGWKALFADEKQAQEQEDNTALPALKKEEISPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRESAGLGTEATRAGIIEALFKRRLLARKKKNLHATQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRRGNSPD
(50) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSIIVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILPGEKTESLWQAGLGRARADWLMGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVVATLQKDGIGFRVKWLPAPDDCDEEKRCIKEDIAHSVVQCCQEAQNAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDASTLSRVWNDSQITAHHAIIPTRHPFDMTKLTADELKVYQLIRQYYLAQFLPAQETDVTDVTFTIGGQVFQATGRVSVVTGWKALFADEKQAQDQDGNTALPVLKKAETCPVIRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEALFKRRLLARKKKNLHATQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRRGNSPD
(1671) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAAETGRQTE
(284) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1883) DNA topoisomerase 3 [Salmonella bongori NCTC 12419]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWSLADLPIVPEKWQLQPRPSVTKQLNVIKRFLQDAGEIVHAGDPDREGQLLVDEVLDYLQLPAEKRQRVQRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMKAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYALIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPIVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVRQFRGIIAPVGEGKKKSAPRKRPAKKSPPQA
(844) DNA topoisomerase 1 [Salmonella bongori NCTC 12419]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGDALPLQVTHQNDKPFRPVSREQTLAAISLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVSVMAESLKDMEADAQKLYQLIWRQFVACQMTSAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKSDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVIRFSRKTKQQYVAAEKEGKATGWSAFFVDGKWVEGKK
(743) DNA topoisomerase [Serratia plymuthica AS9]
4
MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPWRESVLPIVPTQWKMAIKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHFTGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAREQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRGTLQKGGIAFPANWVPAANYCDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMSANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRAFVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEATFNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELKTLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYLEKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGHLVEKGKTQAVKFTAPPSPPCPTCSGSMRRRAGKKGGGAFWGCSNYPTCQGVINIDAKGGRKAKRYKAKSPTKNKATGSE
(369) DNA topoisomerase 3 [Serratia plymuthica AS9]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGNNDVVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNAIKKLLHDADEVVHAGDPDREGQLLVDEVLDYLALTPEKRHSVRRCLINDLNPQAVERAIDRLRDNRDFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVPKDFFEVKAHIVTPKEERFVALWQPSDSCEPYQDEEGRLLHRPLAEHVLKRIEGQPALVTSYNDKRESDTAPLPFSLSTLQIEASKRFNLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISAHQPDLYPQPVIDSDRRNRCWDDKKVDAHHAIIPTARASKVSLSQDELNVYGLVARQYLMQFCPDAMFRKCVIELDIAGGKFVAKARFLAEAGWRTLLGSKERDEENEGSPLPVVAKDDELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIELLFKRAFLYKKGRYIHSSETGRALIHSLPDIAARPDMTANWEATLTQISEKSCRYQDFMQPLVGTLQELIYQAKQSRASMAFRGLPPSPSAGAKKRKKSAGKAREKSE
(1540) DNA topoisomerase 1 [Serratia plymuthica AS9]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTEDKAKKKVKKDEKTALVNRMGVDPYHGWKADYEILPGKEKVVAELKSLAENADHIYLATDLDREGEAIAWHLREVIGGDEKRFSRVVFNEITKNAIQQAFKQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKNDTALQMEVTHAHDKPFKPVNREQTHAALKLLEKARYTVLDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGDNFGDKYLPKAPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLSVKAGDYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPYVEVGSDLELQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEENFRELMNYDFTARMEDGLDQVANNHAEWKAVLDEFFAEFSEQLETAEKDPEDGGMRPNQMVMTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPETEVLNILEGDDAETNALRARHRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEEGEFRLKGYDGPVVECDKCGSEMHLKMGRFGKYMGCTNETCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADGEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(1816) DNA topoisomerase 3 [Shigella boydii Sb227]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTRQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA
(1810) DNA topoisomerase 1 [Shigella boydii Sb227]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(310) DNA topoisomerase 3 [Shigella flexneri 5 str. 8401]
10
MANWCQRAAVVPWLRSVNLMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIA
(1024) DNA topoisomerase 1 [Shigella flexneri 5 str. 8401]
9
MRRIPGRIKLGKVNMGKALVIVESPAKAKTINKYLGCDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(366) DNA topoisomerase 3 [Yersinia enterocolitica subsp. enterocolitica 8081]
10
MMRLFIAEKPSLARAIADILPKPHRRGDGFIACGSDNMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWRLQPRPSVSKQLNVIKQLLQQADEVIHAGDPDREGQLLVDEVLDYLDLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRIAGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISMHQADLLPLDVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKQNRSPQVFRGLPAAPSGAIKKRKKTSSKTKENKS
(1742) DNA topoisomerase 1 [Yersinia enterocolitica subsp. enterocolitica 8081]
9
MGKALVIVESPAKAKTINKYLGNNYVVKSSVGHIRDLPTSGSASKKSANSTEDKAKKADKPKTKVKKDEKVALVNRMGVDPYHGWKAQYEILPGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKGEVPIQMEVTHAHNKPFKPVNREQTHAALKLLENARYKVLDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPSAPNQYSSKENSQEAHEAIRPSDVNVMAEQLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSELDLQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESGLDQVANDQAEWKAVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVMTSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEAEILNILEGDDAETNALRAKRRCQKCGTAMDSYLIDNQRKLHVCGNNPTCDGYEIEEGEFRIKGYEGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVTDNEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEAKK
(323) DNA topoisomerase 3 [Yersinia pestis A1122]
10
MRLFIAEKPSLARAIADILPKPHRRGDGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPVGPSGAPKKRKKISSKAKESKS
(1303) DNA topoisomerase 1 [Yersinia pestis A1122]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSANSAEEKAKKDDKPKKKVKKDEKVALVNRMGVDPYHGWKAQYEILSGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNISRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLVAKGDIPIQMEVTHAHGKPFKPVNREQTHAALTLLENARYKVLDREDKPTSSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPATPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQRLYQLIWRQFVACQMPPAKYDSTTLTVQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSDLDLQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESGLDQVANDQAEWKAVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVMTSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPDAEILNILEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEAGEFRIKGYEGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLLELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVVDKEGNKTLVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEAKK
(1001) DNA topoisomerase 3 [Yersinia pestis]
10
MMRLFIAEKPSLARAIADILPKPHRRGDGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTACASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPVGPSGAPKKRKKISSKAKESKS
(1798) DNA topoisomerase 3 [Yersinia pestis]
10
MRLFIAEKPSLARAIADILPKPHRRGDGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPVGPSGAPKKRKKISSKAKESKS
(490) DNA topoisomerase 3 [Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGDNQFVTWCIGHLLEQAEPDAYDSRFARWSLVDLPIVPEKWQLKPRPSVAKQLDIIQELLKKADEVVHAGDPDREGQLLVDEVLDFLNLDGEKRKNVRRCLINDLNPQAVAKAVDRLRDNRDFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYRGVLSVGRVQTPVLGLVVRRDEEIEHFVPKDFFEVKAHIVTPKDERFTAIWQPSESCIDFQDEEGRLIHRPLAEHVVARITGQPAYVTSYQDKRESEVAPLPFSLSSLQIEAAKRFGLNAQQILDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISVHTINLLPQDLLEVDRKNRCWDDKKVDAHHAIIPTARNSHINLTDNEANIYGLIARQYLMQFFPDAIFRKCVIELEIAGGKFIAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKGDELLCERGEVVDRQTQPPKPFTDATILSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKREFLYKKGRYIHATPAGRALIHVLPDIAALPDMTAHWESRLTQISEKQFRYQDFMKPLEETLQQLIWQAKQSRNLQAFRDLPPVPVKGKNGKKSKSGKNTKATAP
(1696) DNA topoisomerase 1 [Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSASQKSSSSSTDKSKKKVKKDEKAALVSRMGVDPYRGWEANYQILPGKEKVVAELKSLAEKADHVYLATDLDREGEAIAWHLREVIGGDSDRFSRVVFNEITKNAIKQAFDKPGELNIDRINAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWQLHADLLAKGEISLHMEVTHKRGKPFKPVNSEQTQAAVSLLEKARYKVVDREDRPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALDMVRGYISDNFGDKYLPKTANTYSSKENSQEAHEAIRPSSVDVMAEQLKDMDADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFELRAKGRTLRFDGWTKVMPALRKGDEDHTLPVVEVGTELDLQQLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYSEKMGEIVTDRLEENFNELMSYDFTARMEDQLDQVASNKAEWKGVLDEFFTDFSEQLEVANKDPEDGGMRPNPMVITSIACPTCDRPMGIRTATTGVFLGCSGYALSPKERCKQTINLIPENEILNILEGDEAETNALRARRRCKKCGTAMDSYLIDNQRKLHVCGNNPACDSYEVEEGEFRIKGYDGPVIECDKCSSEMHLKMGRFGKYMGCTNETCKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADAEGNKTVIRFSRKTKQQYAASEKNGKATGWSVFYVDGKWIEKDKK
(147) DNA topoisomerase 3 [Citrobacter rodentium ICC168]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLSDLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEVVHAGDPDREGQLLVDEVLDYLQLAAEKRQQVQRCLINDLNPQAVERAIERLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFIPKDFFEVRAHIVTPADERFIAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPAFVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIGVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSTINLSENEAKVYNLIARQYLMQFCPDAVFRKCVIELEIAKGKFIAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKSTPVRRFRGIVAPGGGSSEKKKSAPRKRAAKKSPPSAEAGL
(1777) DNA topoisomerase 1 [Citrobacter rodentium ICC168]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGDALPLQVTHQNDKPFRPVNREQTQAAVSLLEKARYTVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDSFGKKYLPDSPNQYASKENSQEAHEAIRPSDVTVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLVELIPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHEAEWKAVLDNFFSDFTQQLDKAEQDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVAAEKDGKATGWSAFYVDGKWVEGKK
(814) DNA topoisomerase 1 [Buchnera aphidicola str. Ua (Uroleucon ambrosiae)]
1
MSKSLVIVESPAKAKTINKYLGNEYIVKSSIGHVRDLITRKFKKPTHKSQKYSQSYSLNNKQKTYFIENIGIDPYKDWKAEYSILPGKEKIISELKNIAHKVDHIYLATDLDREGEAIAWHLKEVIGGDSTKFSRVVFNEITKHAIKKAFKNITKINMHRVHAQQARRFMDRIVGYMISPLLWEKISRGLSAGRVQSVAVRIIAEREDIIKKFIPEEYWKLNVSFVLKNQNKIIMDVTHFNNKKFRPNNQNELNIAIEEIKKSSFFIKKFEKKIIYKQAPAPFITATLQQSASLILGFSVKKTMFLAQKLYEEGYITYIRTDSCYLSLNAINKVRKYIKKFYGDAYLSNKYYIHTNKKHSQEAHEAIRPSDIKVKNINTNTINLDAEKLYLLIWNQFIASQMKPAQYQFITIKIFSHLFQLQKQLKIVLFDGWTKMFKEKNENITQIPIIDIGSILNIDNIIINQKFTKPLPRFTEASLVRELEKKGIGRPSTYSVITSKIQERGYVTIKKNKFYAEKMGSILTIRLKKSFSNLIDYNFTANMEKKLDQIAENKLSWINVLNSFFKDFSEKLDQAKKNPEEGGMELNNIVFTSIKCPTCFKKMGIKNAITGVFLSCLGYQDNLKKRCKQTINLIPLNDVLKKKQNNEVTSGFTKLINKCEKCNMFMDSYFINKNIQLHICINNPSCIGYKVEKGNFKIPIWLSKTVECDKCYSNMLLKKGPFGKFFICVNIKCKNTRKILPNGEISDPKLEPIPFPELLCKKSNASFVLREGVSGIFFAASTFPKSRETRSPFIEELAKFQYLLPKKIYYLSKAPIVDDKGNKTIVCFNRKNKEYYVTSKKKGKFTGWSAVFIKNKWCVINQ
(198) DNA topoisomerase 1 [Candidatus Vesicomyosocius okutanii HA]
1
MAKNLVIVESPTKAKTIEKFLGKDFSVKSSIGHIRDMPKKNMGIDIDNNFTPTYEITADKKKVVTDLRKAVKVAEKVYLATDEDREGEAIAWHLLEALNLPKDTPRIVFHEITKNAITHAISEPRIVNYRLVDAQQARRIIDRLVGFEISPILWRKISGARSAGRVQSPVVRLVVEREREISKHIDNSTYKVKAELSSESGEIFKVKLSKEFKSKKQVLAFANILLLANLTITSIEKKPFKRSPKPPFITSTLQQEAFQKLGFSVKQTMILAQNLYRKGFITYMRTDSFILSETAIEAVHKIIVREFGSEYHNTRRYKSKESRAQEAHEAIRPTDLTRSNIFDIEEQAAKLYILIYKRTLSCQMSDAQLQKTKIKINIEGLDEIFIANGEVLVFPGFLRIYDYLLSEDKLLPRLNKGNALNLVNFKARESFSRAKPRYTEASLVKKIEEMGIGRPSTYSTMVSTVQDRNYVTKKNGRGVEREYQLIEIKDNQVIQSQPSEVISGEKNKLFPTNIAYLLTDFLVKYFNNIIDYKFTAKLESDFDTIATQNISWQGVVKNFYIPFHQKIEDAVNISREEIHSMRNLGVDPKSDKPVSVRVGRYGAFVQIGHTDDKDKPTFASFRGLLDIESITLDEALELFNMPRHLGETDNFGTIKANYGRFGPYIQYGKKYVSLKEDIPEEVSLEKALELIKIKEKFDSERIIKIFDGSDIQLLNGRFGPYIWNGKKKGKGQKNITIKKVFGDKPIANLTLEECKKAISGKLKLKKKIVKKEVTKNS
(1021) DNA topoisomerase 3 [Rahnella sp. Y9602]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGNDQVVTWCVGHLLEQAQPDAYDSRFARWSLADLPIIPEKWQLQPRSSVAKQLNVIKRLLLEASQVVHAGDPDREGQLLVDEVLDYLELTPEKRHATQRCLINDLNPQAVERAIERLRDNRDFIPLCVSALARARADWLYGINMTRAYTILGRNAGYNGVLSVGRVQTPVLGLVVRRDEDIENFVPKDFFEVKAHIVTPAEERFVALWQPSDSCEPYQDEEGRLLHRPLADHVVARIAGQPAMVTGYNDKRENDIAPLPFSLSTLQIEGSKAFGLSAQQILDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAIGVHRPDLMPQPAVDTDLRNRCWDDKKVDAHHAIIPTARSSNVNLTDDERKIYGLVARQYLMQFCPDAVYRKCVIDLDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGTPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFRREFLYKKGRYIHSSDTGRALIHSLPDIAARPDMTADWESTLTRISEKSCRYQDFMQPLVATLQNLIMQAKTNRVSSAFRSLPSKPAGAVAKGKSAPKRRKASTKGKEANSDE
(936) DNA topoisomerase 1 [Rahnella sp. Y9602]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKTADSTEEKTKKKVKKDEKTALVNRMGVDPYHGWEAQYEILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQNAFKEPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLLAKKETALQMEVTHHLEKPFKPVNKEQTHAAVSLLEKARYTVVDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVEMVRGYIGENFGDKYLPKAPLQYSNKENSQEAHEAIRPSDVAVISEQLKDMEADAQRLYQLIWRQFVACQMTPAQYDSTTLTVKAGDYSLRAKGRTLRFDGWTKVMPALRKGDEDRTLPAIEVGTDLELQQLLPTQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVHVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMEDGLDQVANNKAEWKAVLDEFFTEFSKQLETAEKDPEEGGMRPNQMVLTSIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLIADAEVLNILEGDEAEANALRAKRRCVKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELKRFKDRLPEKLSYLADAPVADPEGNKSMVRFSRKTKQQYVSSEKDGKATGWTAFFVDGKWVEGKK
(418) DNA topoisomerase 3 [Rahnella aquatilis CIP 78.65 = ATCC 33071]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGNDQVVTWCVGHLLEQAQPDAYDSRFARWSLADLPIIPEKWQLQPRSSVAKQLNVIKRLLLEASQVVHAGDPDREGQLLVDEVLDYLELTPEKRQATQRCLINDLNPQAVERAIERLRDNRDFIPLCVSALARARADWLYGINMTRAYTILGRNAGYNGVLSVGRVQTPVLGLVVRRDEDIENFVPKDFFEVKAHIVTPAEERFVALWQPSDSCEPYQDEEGRLLHRPLADHVVARIAGQPAMVTGYNDKRENDIAPLPFSLSTLQIEGSKAFGLSAQQILDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAIGVHRPDLMPQPAVDTDLRNRCWDDKKVDAHHAIIPTARSSNVNLSDDERKIYGLVARQYLMQFCPDAVYRKCVIDLDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGTPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFRREFLYKKGRYIHSSDTGRALIHSLPDIAARPDMTADWESTLTRISEKSCRYQDFMQPLVATLQNLIMQAKTNRVSSAFRSLPSKPAAAKGKSAPKRRKASTKGKEANSDE
(1587) DNA topoisomerase 1 [Rahnella aquatilis CIP 78.65 = ATCC 33071]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKTADSTEEKTKKKVKKDEKTALVNRMGVDPYHGWAAQYEILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQNAFKEPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLLAKKETALQMEVTHHLEKPFKPVNKEQTHAAVSLLEKARYTVVDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVEMVRGYIGENFGDKYLPKAPLQYSNKENSQEAHEAIRPSDVAVTSEQLKDMEADAQRLYQLIWRQFVACQMTPAQYDSTTLTVKAGDYSLRAKGRTLRFDGWTKVMPALRKGDEDRTLPAIEVGTDLELQQLLPTQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVHVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMEDGLDQVANNKAEWKAVLDEFFTEFSKQLETAEKDPEEGGMRPNQMVLTSIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLIADAEVLNILEGDEAETNALRAKRRCVKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELKRFKDRLPEKLSYLADAPVADPEGNKSMVRFSRKTKQQYVSSEKDGKATGWTAFFVDGKWVEGKK
(1002) DNA topoisomerase [Halothiobacillus neapolitanus c2]
4
MRVYLCEKPSQARDIAAVLGIQSKDKSSITTADGVVTWAFGHLLEQAPPDAYDDSLKRWALASLPIAPTQWKVEVKSSAKDQFKAIATLLKRATEVVIATDADREGEMIARELMAFVGFKGKVQRLWLSALDAASVKKALAALKPSAETAGLYQSALGRSRADWLVGMNLTRAFTLAGCSQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFFEAGQSFSTKWKVPEGAGDDAGRCVDQSIVDAVASKITGKTGTVSQYETKRISENPPLPFSLSTLQKTCSAKFGLGAQEVLDIAQALYETHKATTYPRSDCNFLPEEQFQEASSIVTALAKSDTEVQGIVDLLDFSRKSPAWNTKKITAHHAIIPTQTPPNMDAMSDNERRVYELIRRQYLAQFLPNYEYDRTQIGISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLPALTQGQTLPLSHTEIAAKQTKPPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTEATRAGIIANLIERGFITKKGKQVISSDVGRQLIDALPDSVKSPALTALWEQSLEEIAEGKRELAGFEADVVKFITAIIDQIKKQHADAPAPTRPTADCPTCKAQGQAEKVYSIKKQCHYWHCKACNQWFDDAAGKPVPKAAASSSKTKPAPRKKTTARKAK
(1231) DNA topoisomerase 1 [Halothiobacillus neapolitanus c2]
1
MSQTLVIVESPAKAKTIKKYLGPGYEVLASYGHVRDLIPKDGAVDTAHDFAMNYTLIDKNVRHVDAIKKALKSSDILLLATDPDREGEAISWHLRELLAEAGLLKNKTAQRVVFYEITKKAVQEAVAHPRDLSIDLINAQQARRALDYLVGFNLSPLLWKKINPGLSAGRVQSPALRLIVEREAEIEAFNPQEYWTILADCQADRAAEKSRFNARLLTLDGQKAEQFTLTNETDAQSARSRILEAAAGTLTVRSVEKRERKRNPAPPFTTSTLQQEGVRKLGLSASRVMRLAQELYEGVDIGAGTVGLITYMRTDAVTLSEDALTQIRAHIGDKYGAAYLPASPNRYKTKSKNAQEAHEAIRPTSAAHTPDSVRAFLNKDQFRLYEMIFKRAVASQMTPAVYDQVSVDLAVNDQHSFRANGSTLKFPGFIALYREDEDDASGDNDEDRRLPPLTVGDKIALNDIAADQHFTEPPPRFTEASLVKTLEEYGIGRPSTYASIISTLQAREYVLLDQRRFKPTDMGRVVNGFLTDYFRDIVDYEFTAKLEDDLDAVSRGERDWVPLMREFWTPFHDRVEHTNENVTRQEAAQGRELGIDPKSGKPVSVRLGRFGPFAQIGTKDDEEKPKFASLKRSQSIATITLDEALDLFQLPRKLGETPEGEPVEVAIGRFGPFVKFGKMYASLGKDDDPYTIELPRALEIIEIKKLAEKNRYITQFDNGVSVQNGRYGPYITDGKKNAKIPKDKDPKSLTLEECVALLAAAPEKKSARGKTAAKATAKKTAAPKATAPKTTAKKSTTPRAKKASATDAQAPAKKTPVKKPATARSKKPAATIPE
(1337) DNA topoisomerase 3 [Pantoea ananatis PA13]
10
MRLFIAEKPSLGRAIADVLPKPHRRGEGFIACGNDQIVTWCVGHLLEQAQPDVYDSRYARWSLVDLPIIPEKWRLQPRPSVAKQLKVVEGLLAQADEVVHAGDPDREGQLLVDEVLDYLQLPAEKRSKVQRCLINDLNPQAVERAINRLRENREFIPLCVSALARARADWLYGINMTRAWTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIANFVPKDYFEVKAHIVTPDESRFTANWIPSEACEPWQDEEGRLLKRSLAEHVVARISGQPAIVTAYSDKRENDIAPLPFSLSSLQIEAAKRFGLSAQAVLDICQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAIQSHQPDLTPPADFDADRKNRCWDDKKVDAHHAIIPTARASAVKLNENEQQIYGLVARQYLMQFCPDAVFRKCTIDLDIAGGKFVAKARFLAEAGWRALLGGKERDEENDGMPLPVVAKDDELLCERGEVLAKQTQPPRHFTDATLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFRRSFLHKKGRYIHSTDAGKALIHSLPDLAARPDMTAQWESTLTRISEKACRYDEFMQPLVQTLSGLIQQARQQPSGQAFRGLPSTGQKRPPRKAGRKTKETE
(130) DNA topoisomerase 1 [Pantoea ananatis PA13]
9
MGKALVIVESPAKAKTINKYLGSGYVVKSSVGHIRDLPTSGSTAKKSAETSTDKKVKKVKKDEKAALVSRMGVDPYHGWEADYQILPNKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIRQAFDTPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELSANLTTPKGDDLAMDVTHAGDKPFRPVNHEQTHAALALLEKARFAVTDREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVSMVRGYIEGNFGKKYLPDNANTFASKENSQEAHEAIRPSDVDVVAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVTAGDYKLKAKGRTLRFDGWTKVMPALRKNDEDRTLPPVNVGDELSLQALLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYAAIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMESSLDQVANNQAEWKAVLDRFFSDFSQQLEQAEKDPEEGGMQPNQMVLTTIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCQKCGTAMDSYLIDNGRKLHVCGNNPECDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFHDRLPEKLKYLAEAPATDPEGNKTLVRFSRKTKQQYVASEKEGKATGWSAFYIDGKWQEAKK
(1818) DNA topoisomerase [Pantoea ananatis PA13]
4
MRLFLCEKPSQGRDLAAVLGASRRGEGFMTGNGVTVTWAVGHLLETAPPEVYGQQYGKPWSLSALPILPSRWQVVVKKDTQDQFKVIEKLLRQADEVVIATDADREGEVIARELLDYCGWDGRILRLWFSALDELSVRAALSDLRPGQASVGMYHAGLGRSRADWLIGMNLSRLYTLRAAEAGFEGVVSVGRVQTPTLALVARRDREIAAFVPKPYWQVKATLSASGVSFQASWVPAAVYADEEKRCIHQNIAQQVAQLCRQAGVSTVTEYETKREKEAAPLAFSLGTLQRACGKMWNMSPQKVLDTAQSLYETHKATTYPRTDCGWLPKSMREEIPAVFDAMARTDPSPEFASLLSQLDRGFASRIWNDKKITAHHGIIPTRNAVQLSSLTETERQVYLLIRRNYLAQFLPLCESDATRISFDIGGQLFRTTGRTEVLKGWKVLFTKDEEDKDTAEEDIAGSLPPLSKGAQCGVTDAEVKQLMTQPPAHYTFDTLIGAMMNAAAYVTDLQLRKILKENAGLGTEATRAGIIEQLLSRRFITLKGSKLLATDLGADVIDALPPQLTDPGMTALWEQALDEVAAGRMNLNDFLQRQTAWTSTLVSQGMQQRISIRVPPSPPCPLCGSKTALRRSPKGEFRSCTRYPECKGIISLDSGRRKSPARAKSPKTKKN
(536) DNA topoisomerase 3 [Pantoea sp. At-9b]
10
MRLFIAEKPSLGRAIADVLPKPHRRGEGYIACGNDQVVTWCVGHLLEQAQPDSYDSRYARWNLADLPIIPEKWQLQPRPSVAKQLKVIEGLLAQATEVVHAGDPDREGQLLVDEVIDYLQLPAEKRQKVQRCLINDLNPQAVERAVSRLRENREFIPLCVSALARARADWLYGINMTRAWTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFIPKDYFEVKAHIVTPKDERFVASWVPSDACEPWQDEEGRLLHRPLADHVLERINGQPARVTAYNDKRESEIAPLPFSLSSLQIEAAKRFGLSAQNVLDCCQRLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIQAHQPDMTPPADFNPEQRNRCWDDKKVDAHHAIIPTARASKVNLSENEANIYGLIARQYLMQFCPDAVFRKCVIDLDIAGGKFVAKARFLAEAGWRALLGSKERDEENDGTPLPVVSKGDELLCERGEVLAKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFRRTFLVKQGRYIHSTQAGRALIHALPEMAARPDMTAHWESTLTRISEKACRYDEFMQPLVSTLIGLIGQARQQPSLQAFRGIAASGSASEKKRTRKPARRKMKETE
(702) DNA topoisomerase 1 [Pantoea sp. At-9b]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTARKSADGEKTKPAGKKVKKDEKAALVNRMGVDPWHGWQADYQILPGKEKVVSELKSLAADADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIRQAFEKPGELNIERVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDADLVTPKGDALAMQVTHQGDKAFRPVNREQTYAAVALLQKARYDVLDREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAIAMARSYIDKNFGANYLPAAPNTYASKDNSQEAHEAIRPSDVAVAAEKLKDMEADAQKLYQLIWRQFVACQMVPAQYDSTTLTVGAGDFKLKAKGRTLRFDGWTRVMPALRKNDEDLTLPPVNVGDVLDLKEVLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDSLDQVANNQAEWKGVLDSFFSDFSQQLDQAEKEPEEGGMQPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNVLEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEQGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFADRLPEKLKYLAEAPAADPEGNKTMVRFSRKTKQQYVASEKEGKATGWSAFYVDGSWQEAKK
(535) DNA topoisomerase 1 [Alkalilimnicola ehrlichii MLHE-1]
1
MSKNLVIVESPAKAKTINKYLGKDYKVLASYGHVRDLVPKEGAVDPEHGFAMKYTTIDKNAKHVDTIAKAMKQADALYLATDPDREGEAISWHLYELLKEKGALKDKPVYRVVFHEITPRAIREAMEHPRELSTPLINAQQARRALDYLVGFNLSPLLWKKIATGLSAGRVQSPALRMIVEREEEIEKFISREYWTVEADLARNGEAFPGRLHTLDGQRVKQFDIDNGERAREVEHQLARAAGMALSKSHIDAGEGESPVQSPGTVQVTQVEKKQRRRNPAAPFTTSTLQQEAARKLGFTANRTMRVAQQLYEGIDIGGGVTGLITYMRTDSVNLSQEAVADLRDTIAKRYGEDRLPKAPQVYRTKSKNAQEAHEAIRPTGAFRLPEEVRGKLSDDQFRLYELIWKRAVACQMIPALINTVAVDLACGEGNSFRATGSTIAEPGFMAVYLEGTDDRKPDVGSSERILPPLKEGDKVALERIKPEQHFTEPPPRYTEASLVRALEEYGIGRPSTYAAIISTLQQRKYVELDGKRFRPTDIGRVVNRFLTDHFDRYVDYDFTARLEDDLDAVSRGERDWVPLLEEFWQPFKDKVDEKATISREEVMQSRDLGTDPKTGKPVSVRVGRFGPFVQLGTKDDEEKPRFAGLRPGQSMDKITLEEALELFKLPRDMGETPEGEPMQVNIGRFGPYVRFGNKFVSIKDDDPYTISRERCLELVEEKKRIERERTIRDFEGSDIRILKGRYGPYITNGKKNARIPKDREPESLGLEECEELIAKAPERKGRRRTGGTGRKRSTKA
(715) DNA topoisomerase 3 [Pantoea vagans C9-1]
10
MRLFIAEKPSLGRAIADVLPKPHRRGDGFIACGNDQIVTWCVGHLLEQAQPDSYDSRYARWSLNDLPIIPEKWQLKPRPSVAKQLKVVEGLLAQASEVVHAGDPDREGQLLVDEVLDYLNLPPEKRSKVQRCLINDLNPQAVDRAVNRLRENREFIPLCVSALARARADWLYGINMTRAWTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFEVKAHILTPDGARFVASWIPSEACEPWQDEEGRLLKRALADHVVARITGQPAIVTAYSDKRENDVAPLPFSLSSLQIEAAKRYGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPEEHFAGRRTVLKAIQAHQPQLTPPADFNADRRNRCWDDKKVDAHHAIIPTARSSAVKLSENEQHIYELVARQYLMQFCPDAVFRKCVIDLDIAGGKFMAKARFLAEAGWRALLGSKERDEENDGMPLPVVAKGDELLCERGEVLAKQTQPPRPFTDATILSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFRRGFLVKKGRYINSTDAGRALIHSLPDLAARPDMTAQWESTLTRISEKACRYDEFMQPLVQTLTGLIQQARQQPAAHAFRGLPSTGQKRPVRKTRRKVKETE
(582) DNA topoisomerase 1 [Pantoea vagans C9-1]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSTAKKSADASTDKKVKDASTDKKVKKVKKDEKAALVSRMGVDPYHGWEADYQILPGKEKVVAELKALAANADHIYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVNAALTTPKGDELSMDVTHKGDKAFRPVNRDETYAAVALLEKARYEIVDREDKPTSSKPGAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVAMARGYIESNFGKKYLPETAITYASKENSQEAHEAIRPSDVEVVAEKLKDMEADAQKLYQLIWRQFVACQMTPAKYDSSTITAAAGEFKLKAKGRILRFDGWTKVMPALRKNDEDRTLPAVSVGDVLDLQQLLPGQHFTKPPARFSEASLVRELEKRGIGRPSTYAAITSTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESNLDQVANNEAQWKAVLDHFFADFTQQLELAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCQKCGTAMDSYLIDNERKLHVCGNNPECDGYEIEKGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRSGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFKDRLPEKLKYLADAPAADPEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWQEAKK
(885) DNA topoisomerase 1 [Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum)]
9
MGKSLVIVESPAKAKTINKYLGSHYVVKSSVGHIRDLPKSGSNNKKNASEIIKKQKTEKKMFQDHQSSLIKRMGIDPYHGWKAQYEILSGKEKVVSELKALAAKADHIYLATDLDREGEAIAWHLREVIGGDPQRFSRVIFNEITQNAIQQAFKKPGELNMNRIHAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPQEYWHLEANLLTPQKIMIPMMVSHFEGEPFKPLNREQTYAAVNDLEDAQYVVLDRKDKPTSSKAGAPFITSTLQQAASTRLGFGVKKTMLMAQRLYEAGHITYMRTDSTHLSQDALSMVRNYIQKHFGNRYLISPAYEYGNKKNAQEAHEAIRPSNVDVFSEQLEDMEPDARKLYQLIWRQFVACQMTPAQYDVTTLIVEAKNYQLRAKGRTLRFDGWTKVMPALRKGDEEETLPIIAVGTSMHLEKLIPSQHFTKPPGRYSEASLVKELEKRSIGRPSTYATIISTVQERGYVRIENRRFYAEKMGEIVTNRLEENFRELMNYDFTARMENALDQIAQHQAEWKKVLDEFFSEFSEQLNIAEKDPSEGGMRPNSMVIMDINCPACGQKMGIRTASTGVFLGCSSYALPPKERCKTTLNLISENEILNLLDGDEAETNALRSRRRCEKCETAMDSYLLDTARKLHICGNNPICDGYQMEQGEFRIKGYEGPIVECDKCAHEMHLKVGRFGKYMGCTNEECKNTRKILRNGEVAPPKENPVPLPELLCEKSDAYFVLRDGAAGLFLAANTFPRSRETRAPRVEELQRFKDRLPEKWHYLVEAPLKDTEGNKTFLRFSRKTKEQYISSEKSGKATGWCAFYIDGQWVEGKKRPLVKS
(1163) DNA topoisomerase 3 [Escherichia fergusonii ATCC 35469]
10
MPWLRFVKSMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDTYDSRYARWNLTDLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNNKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRCIVAPDGGEGNKKTSSRKRAAKKSPPADEAGSGAIA
(1194) DNA topoisomerase 1 [Escherichia fergusonii ATCC 35469]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANTTTPSGDALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPAGNKSMVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEGKK
(824) DNA topoisomerase 3 [Escherichia coli NA114]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETYKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTSVRQFRGIMAPGGGEGKKKDSPRKRAPKKSPPSEEAGNGVII
(307) DNA topoisomerase 1 [Escherichia coli NA114]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(1300) DNA topoisomerase 3 [Cronobacter turicensis z3032]
10
MRLFIAEKPSLGRAIADVLPKPHRRGDGFIECGNGQVVTWCVGHLLEQAQPDAYDSRYGRWNLADLPIVPEKWQLQPKPSVAKQLNVIKKLLREAQEIVHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDKLRENREFVPLSTSALARARADWLYGINMTRAYTLLGQNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFVAKDFFEVKAHIVTPAQERFTALWQPSEACEPYQDEEGRLLNRALAEHVVKRIEGQPARVTSYNDKREGEAAPLPFSLSTLQIEASKRFNLSAQAVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLKAIGVHASDLLPQPAVDPERRNRCWDDKKVDAHHAIIPTARSAPASLSDGEAKIYGLIARQYLMQFCQDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGAKERDEENDGTPLPVVAKGDELHCERGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLEKQGRYIHSTPAGKALIHALPELAARPDMTAQWESTLTQISEKQCRYQDFMQPLVHTLYTLIDQARSAPVRQFRGLVAPQQAQKRRAGKGGKKPAARKRSGAQPATE
(1760) DNA topoisomerase 1 [Cronobacter turicensis z3032]
9
MGKALVIVESPAKAKTINKYLGKDFVVKSSVGHIRDLPTSGSAPKKSAESAPTKPAKKVKKDERGALVNRMGVDPWHNWEAQYEVLPGKEKVVSELKSLAEKADHIYLATDLDREGEAIAWHLREVIGGDETRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDALLSTPKSDQLSVQVTHHKDKPFRPVNRQDTEAAVALLKAASYQIVEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVSMVRNYIGEEFGKKYLPENPNQYASKENSQEAHEAIRPSDVSVLAESLKDMENDAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFRLKARGRILRFDGWTRVMPALRKGDEDRTLPAVNQGDKLSLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFPELMNFDFTAQMEDSLDQVANHEAEWRGVLDTFFDDFSRQLDTAEKDPEEGGMRPNQMVLTSIDCPTCGRPMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEVEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFRDRLPEKLLYLADAPAQDPEGNPAVVRFSRKTKQQYVASEKDGKATGWSAFYVDGKWAEGKK
(1411) DNA topoisomerase 1 [Candidatus Moranella endobia PCIT]
9
MGTALVIVESPAKAKTINKYLGKGYVVKSSVGHIRDLPKKSPASKNKNNTCIPDQHTVLIKRMGIDPFHSWKARYEILPGKEKLVTELRALAEEADHVYLATDLDREGEAIAWHLREAIGGDEKRFRRVVFNEITRNAVTQAFENPVVLNMNRVNAQQARRFMDRIVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKSFMPAEYWELHVALQTSQAAQLMMKVTHQQEKPFKPAKQQQLQAAISILEHTDYIVSNRDDKITTSKPGSPFTTSTLQQAASLHLGYRVKKTMLLAQRLYEAGHITYMRTDSTHLSRNALNMARCYISAAFGHSYLPTQPKEYVSKNNSQEAHEAIRPSDVSALAEQLNNMEAEAQKLYQLIWRQFVACQMKPAQYNYTILTVNAGEFQLSAHGRQLMFDGWTKVMPTQHTEKDKRTLPTVKEGNNLTLNKILPSQHFTKPPARYSEASLVKELEKRGIGRPSTYVSIISTIQERGYVHADNRRFYAEKIGEIVTDRLEENFSELMSYDFTAKMEATLDQVATNQQDWKSVLDAFFSKFSQQLKNAEQNPVDGGMRLNQMIMTSINCLVCDRPMGIRTASTGVFLGCSGYQLPPKDRCKNTIHLIPESETLNRFTVGDEETNALRARRRCVKCRTAMDNYVIDSKRKIHVCGKNPLCDGYNIEQGEFIVVAYNGRVVECEKCGFNMQLKFGRFGKYIACTNNNCKNTRKILRNGDVAPPKEDPVLLPELPCYGHSDAYFVLREGAVGVFLAANTFPKYRETRKPLVAELARFRERLPVKLQYLADAPIEDDEGNSTLVRFSRKTKQQYISSEKDGKATGWTAFYVNGKWQVNRKSSGCGP
(462) DNA topoisomerase 3 [Enterobacter cloacae EcWSU1]
10
MRSVNSMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLNDLPIVPEKWRLQPRPSVTKQLNVIKRFLHDATEVIHAGDPDREGQLLVDEVLDYLELAPEKRQQVQRCLINDLNPQAVERAISRLRANSEFIPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPKDERFTAVWQPSDACESYQDEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESEPAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHSVMNAIAVHAPDLLPQPVVNPDIHNRCWDDKKVDAHHAIIPTARASNVNLTENEAKVYNLVARQYLMQFCPDAVFRKCVIELEIAKGKFIAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLEKKGRYIHSTEPGRALIHSLPELAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYELINQARNTPVKQFRGMVAPGGAPKKPFKKKKSAA
(542) DNA topoisomerase 1 [Enterobacter cloacae EcWSU1]
9
MNMGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERSALVNRMGVNPWHNWDAQYEVLPGKEKVVNELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANVTTPGGDALPLQVSHQNDKPFRPENRDQTMAAVALLEKARYQVLEREDKPTSSKPGAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPESANQYASKENSQEAHEAIRPSDVSVLAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDELSLVDLVPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEANFRELMNYDFTAQMEDSLDQVASHQAEWKKVLDSFFSDFTNQLEKAEKDPEEGGMLPNQMVLTSIDCPTCGRKMGIRTATTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELHRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKEGKATGWSAFFVDGKWVEGKK
(231) DNA topoisomerase 3 [Vibrio vulnificus YJ016]
10
MTRLFIAEKPSLGRAIAAALPNPQKKEQGFIRCGNGDIVTWCIGHLLEQVEPDAYDERYKKWNMADLPIIPEQWQLRPRPSASKQLTVIRKLLKEASEVIHAGDPDREGQLLVDEVLDYCKLSQTKKAQTQRLLISDLNLPAVKRALSSLRSNRDFVPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPRDFFTLHALIPYQNGSEPFDIKARWKPSEACQPWQDEEGRVLSRKLVENVASRIANQPATVTESEHKQTKQAPPLPYSLSALQIDAAKRYGMSAQQVLDTCQSLYEKHKLITYPRSDNRYLPKEHYAQAASVSQAIANNAKELSDAVSGADLSLKSKAWNDSKVEAHHAIIPTPKQASVNALSGYEMKIYQLIARQYLMQFYPAATYAEAKLVFEIAGGVFIAKGRQLTFAGWKALTGATEKEEDGADTVPPLAKGTVLTCREGVIKDCKTEPPKHFTEATLLQAMTGIARYVSDKELKKILRETDGLGTEATRAGILDTLFKRQLLSRQGKAILSTPAGRGLIHALPQESTYPDMTAHWEHQLQGMAERNQAYQPFMAALQQRISELMQQVTTSPVPSSLRQLPPVERPAFKRKRRASTSKKTASTATQKRTNKSA
(1105) DNA topoisomerase 1 [Vibrio vulnificus YJ016]
9
MGKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTAGQSTGEKAAAISTKGMSVEEKARIKQKKDRNALIKKMGIDPYHDWAANYQILPGKEKVVSELQKLAKDADFVYLATDLDREGEAIAWHLREIIGGDETRYKRVVFNEITKNAIQQAFQKPGHLNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDIHANTLTQETMPFKLLVAQKSGDAFRPVNEAETKAALAVLQKAQFEVCKREDRPTKSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSQEAVEAVRGYISDEFGSRYLPKAPLVYGSKQGAQEAHEAIRPSDVNIKADALEGVDADAHKLYALIWNQFVACQMTEAEYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDTILPAVQVGDKLNLESLEPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEEKLDKIAEGDVNWKDVLNQFFADFTTDLGRAEEDEAHGGMKPNHIVMTDIQCPTCSRPMGIRTASTGVFLGCSGYALPVKERCKTTINLGDEEGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYLVEHGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHFPELPCSNSDAYFVLRDGAAGLFLAASNFPKSRETRVPLVSELARFAERLPEKYKHLAQAPTQDPDGVEAVVRFSRKTKENYVRTEVDGKPTGWTALYVDGKWEVTDKRKNAK
(64) DNA topoisomerase 1 [Baumannia cicadellinicola str. Hc (Homalodisca coagulata)]
9
MNKALVIVESPAKAKTINKYLGNQYLVKSSIGHIRDLPIHRETVKQQGKTNYQNTLANRMGIDPYNNWFANYEILPGKEKLVNELKALANKAKHIYLATDLDREGEAIAWHIREVIGGDNSKFSRVVFNEITCNAITQAFQSPRELNLHRINAQQTRRFMDRIVGYMISPLLWKKIARGLSAGRVQSVAVKLIVEREREIKQFSPIEYWDLYSYLQGPKDIVLKMQVTHLNNKPFKPINSLQVQSAIALLNNARYIVCCREDKITSSNPNAPFITSTLQQAASTRLGYSVKQTMLVAQRLYEAGYITYMRTDSTKISDEAINIVRNYILDIFGSKYLPNQPNQYLSKKNSLEAHEAIRPSNLHILAEQLENIEEDARKLYQLIWRQFVSSQMMPTQYNYTKINVIAGDFQLSTTGRTLHFDGWSKVMPILHKENEESICQSISVGQILSLQQLISQQNFTKPPLRYTEASLVKELEKRRIGRPSTYMSIIDSIQDRGYVKLNNHRFYAKKIGQIVTDRLAENFSELMNYDFTANMEDTLDKVATNQQDWKNVLDTFFIKLNQQLEKAKKSPTEGGMLPNSIVTTSINCPICGRMMGICTANTGVFLSCSGYKLPPKERCKHTINLISESEWLKKLDNENKSIDTQKVRSRCIKCNNIMDSYYFNNNSMLNICNNNPLCDGYEIEQGLCLLNTDYGTLVPCEKCSANMQLRIGRFGKYIACTNNTCKNTRNILRNGDIAPPKMELIEFPELPCKNSNAYFVLRNGAAGVFLAANTFPKVHETRAPLVEELVKFKDRLPTMLRYLTEAPIQDDQGNKTLVRFSRKKKQQYISSEKEGKATSWKAFFINGHWQVYNKEDQ
(804) DNA topoisomerase 3 [Photobacterium profundum]
10
MTRLYIAEKPSLGRAIAAVLPRPHKNNNGYIETGNGDIVTWCIGHLLEQVEPDAYDEKYKKWNMADLPIIPEQWQLSPRKSVKQQLAVVRKLAKQATDIVHAGDPDREGQLLVDEVIDYVKVSAKKKTEIQRLLISDLNPAAVKRALSTMRSNREFIPLSVSALARSRADWLYGMNMTRAYTLLGQKGGYRGVLSVGRVQTPILGLVTRRDDDIANFKPKPFYEVFALIPYQDMDIRARWKPSEACQPWQDEEGRVLNRQLCENVLKRIKGQPAEVTESERKETRQAPPLPYSLSALQIDAAKRFGMSAVDVLANCQSLYEKHKVITYPRSDSRYLPNEHFKQANDVCRAVASNASELSNACNGANTTLKSKAWNDKKVDAHHAIIPTPKQISPNALSGSESKVYQLIARQYVMQFYPAAIYAEAKLVFTITQGHFIARGRQLMSAGWRELLGRDHAEDKTKVAGNSDQGLTDKVPPLDKGTILTCREGEIKDKVTEPPKAFTEATLLQAMTGIARFVSDSSLKKILRDTDGLGTEATRAGILELLFKRQLLMRQAKNIHATDAGRGLVYALPDEATYPDMTAHWEHQLQDMADKKCAYQPFMDALQQQVSQLMDKVKYSEVPESLRQLTSPESRKPMKKKRYTKSKKS
(801) DNA topoisomerase 1 [Photobacterium profundum]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTGARNAGKKAAAQSTAGLSVEEKARLKKIKDRKSLIGKMGVDPYNDWDAHYEVLPGKEKVVSELQKLAADADFIYLATDLDREGEAIAWHLREIIGGDDARYKRVVFNEITKNAIQQAFEEPGELNIDGVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLIVEREREIKAFTPEEFWDIHANTLTVGKDALRLIVSQQAGKAFRPVNEAQTMAAKSVLDSAEYKVVDREDRPTSSKPSAPYITSTLQQAASTRLGYGVKRTMGLAQRLYEAGYITYMRTDSTNLSNDAVVAAREFIGSEYGENYLPKEAIKYGSKKNAQEAHEAIRPSSVEVQAENLEGMDADAVKLYDLIWRQFVSCQMVPAKYDSSTITVQADEFTLKAKGRILRFAGWTLVQRPSGKNEDTTLPIVHVGDVMILEGVEPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVRVDQRRFYAEKMGEIVSDRLDGSFPDLMDFDFTARMEGNLDKIAEGEKNWKAVLDNFFSDFTTELERAELDEDEGGMKPNNIVVTDIECPTCSRPMGIRTASTGVFLGCSGYALPPKERCKKTINLGDEDGIVNVLEEDVETAALRAKKRCPKCDTAMDAYLIDQDRKLHVCGNNPSCDGYIVEKGEFKLKGYEGPLIECDKCGSDMELKTGRFGKYMGCTNEDCKNTRKILKNGEIAPPKEDPVHLPEIPCTQDSNAYFVLRDGASGLFMAASTFPKSRETRAPLVSELVRFKDRLSPKFYYLAEAPTEDPDGREAVVRFSRKSKENYVRTEVDGKPSGWTGLYVDGKWEITDKRKKPKKEKAEKED
(1744) DNA topoisomerase 1 [Thioalkalivibrio sulfidophilus HL-EbGr7]
1
MSKHLVIVESPAKAKTIKKYLGPDFEVMASYGHVRDLVPKEGAVDPDHGFRMNYQVIDRNERHVESIVKALRKADSLLLATDPDREGEAISWHLYELLRERGVLDAKTVQRVVFYEITQRAVKEAIEQPRGLSFDLINAQQARRALDYLVGFKLSPLLWKKIKRGLSAGRVQSPALRMIVEREEEIERFQTREYWTLEADLDKSGQAFNAKLHTLDGKKLDQFDIADEVTASAARNTLLSAADGRLRVARIEKKQRRRNPAPPFTTSTLQQEAVRKLGFSASRAMRVAQQLYEGIDLGAGPIGLITYMRTDSVTLAGEAIAEIRRLIEQRYGRNTLPEHPRQYKTKAKNAQEAHEAVRPTSVMRAPEEVKRHLTTDQFKLYDLIWKRTVACQMQHATLDTVSADLAAGSERHLFRASGSSVRDPGFMAVYQEGKDDAKEESDERILPPLEEGDIVKLEALRAEQHFTEPPPRYTEASLVKALEEYGIGRPSTYASIISTLQQREYVEMDSRRFIPTDIGRIVNAFLTQHFTQYVDYDFTARLEDELDEISRGEKEWVPVMEGFWSSFKEQIEEKEATVTRAEAVQSRELGIDPKSGRPVSVRMGRYGPVVQIGTKDDEEKPRFAGLPPGKKMDAVTLEEALELFKLPRELGETPEGEPVSVNIGRFGPYVKFGSRYASLKPEDDPFSIELPRALELVAEKKEADANKYIRVFDEAGVQVVNGRYGPYITDGNKNARIPKDRDPKSLTLEECQALLAAAPERKGRRGVKKAAPKKKAAAPKKAAPKKKAAPRKKATAKKKAAPKKAAAKKNATSGGESGAGLTR
(1828) DNA topoisomerase [Thioalkalivibrio sulfidophilus HL-EbGr7]
4
MRVFLCEKPSQGKDIARVLGARQRGNGCYSGSGITVTWCIGHLVEAAPPETYGEQYKQWSIEQLPILPERWRIEVKAKTAAQFKIVKQFVAQAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALTQLKPGGETLPLYFSALARSRADWLIGMNLSRLFTVLGRRSGYQGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWTIDVTLSHAGQSFAASWMPPDGTTDAAGRCLQQPVAQQAADRIRAGRESKVLSVETERVREAAPLPFDLGTLQEVCSRQLGLDVQETLDIAQSLYETHKATTYPRSDSGYLPESMLAEVPTVLDALLATDPGLRPLIDRLDRTQRSRVWNDSKITAHHGIIPTLEPANLSAMSEKELAVYALIRAHYLAQFLPHHEFDRTLVMLDCAGQSLQAVGKRVIVPGWHLALPGKGQDAADDEPAQRSQILPPLDTGARCGVQQVELKALKTLPPKPYTQGELIKAMKGVAKLVTDPRLKQKLKETTGIGTEATRAGIINGLLARGYLVKKGRAIRASDAAFTLIDAVPAAITDPGTTAIWEQALDMIEAGQMTLDTFINKQSAWVAQLVQQYRGTVLSIKLPEGPACPVCGAATRQRNGKNGAFWSCSRYPDCKGTLPAESSTGRRRASRQRRAAPKAS
(1802) DNA topoisomerase 1 [Dichelobacter nodosus VCS1703A]
1
MSYKHLLIVESPAKAKTLHKYLGNDYEVLASYGHVRDLIPKNGAVEPENDFAMNYELIERNAKHVAQIEKALKNADELLLATDPDREGEAISWHLFELLQEKGVLAEKTVKRVVFYEITQRAILQAVSAPRDIEMNLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSPALRMIVEREREIDAFQAQEFWNITAHCQQKEEPFLAELTLFAGEKLEQFSFTDEQKTQTAIETLKKQAQGQLTVIDIVSKERKRNPAAPFTTSTLQQEAARKLRSSAQKTMRVAQKLYEAGYISYMRTDSVHLAQEAIEACRLLIEQQYGAVYVPPTPPVYTTKSKNAQEAHEAIRPTDITLEAAMLSAEMGADERQLYDLIRKRTLASQMAAAVMEQTSVDLSAGDTQNIFHATGSIIKFAGFMSVYLEDREESAEENMNLLPKMDIGDVIVLTDIIGSQHFTAPPPRFSEASLIKALEEYGIGRPSTYASIISTLQNREYVESSNRRFVPTTIGKVVNDFLTNHFQRYVDYDFTADLEDELDAIARGEQEWKPLLKDFWAQFKAQIEKKSEISREEVMQARELGMDPKTGKTVTARFGRFGPFVQIGSKDDAEKPLFASIPEDWDFEKISLENALELFKLPRNLGKTEEDEEIVINNGRFGPYVRFGRKFVSLPKDEDPLTISKERALELIALKKEEDRKKHIKEIKNGDDILQVLNGRFGPYVTNGSINASIPKHIEPAALTLEDALALLEKAQERKVNRKKKATEKTSEKKAKTTKTAKKAAPKKSTAKTKSTKQAEKGINHD
(78) DNA topoisomerase 3 [Dickeya dadantii 3937]
10
MRLFIAEKPSLARAIADVLPKPHRRSDGFIACGEQDVVTWCVGHLLEQAQPDVYDARYARWSLADLPIVPQKWLLQPRPSVSKQLNVIKKLLNQADEIIHAGDPDREGQLLVDEVLEYLSLPEEKRQHVGRCLINDLNPQAVERAVSRLRENREFVPLCVSALARSRADWLYGINMTRAYTLLGRNAGYEGVLSVGRVQTPVLGLVVRRDEEIDNFVSRDYFEVKAHIVTPADERFIALWQPSESCEPYQDEEGRLLHRPLAEHVVKRIEGQPAWVTAYNDKRESETAPLPYSLSALQIEAAKRFGLSAQQVLDVCQRLYETHKLITYPRSDCRYLPEEHFAGRQAVLNAIAAHQPDLLPQPAVDPERRNRCWDDGKVDAHHAIIPTARSARTSLTESESQVYGLIARQYLMQFCADAMFRKCVIDLDIAGGKFVAKARFLAEAGWRTLLGNKERDEENEGMPLPVVEKGDELLCERGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKALKKILRETDGLGTEATRAGIIELLFKRAFLVKKGRYIHSTEAGKALIHALPPMAAHPDMTAHWEATLTQISEKRCRYQDFMQPLTQSLHELIQQARQSGNITAFRGLPPVKRAPPAGRKRRQSRSASTKE
(253) DNA topoisomerase 1 [Dickeya dadantii 3937]
9
MGKALVIVESPAKAKTINKYLGNDFVVKSSVGHVRDLPTSGSGSASKKSAEANGEKAKKAVKKDEKTALVNRMGVDPYRGWQANYEILPGKEKVVSELKTLAQNADHVYLATDLDREGEAIAWHLREIIGGDDKRFSRVVFNEITKNAIRQAFENPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWELHADLLANPDIALQMQVTHHNGKPFRPVNQAQTQAAVSLLEKASYVVAEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALAMARDYIQDEFGKRYLPEAPNLYTSKENSQEAHEAIRPSDVKVLADQLKDMEADAQKLYQLIWRQFVACQMMPAQYDSTTLVVSAGDYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPAIDVGQSLSLEKLLPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMENSLDLVANSQAEWKAVLDEFFAEFSKQLETAEQEPDEGGMKPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLIPEAEVLNVLEGDEAETNALRARRRCSKCGTAMDSYLIDNQRKLHVCGNNPSCDGYEIEQGEFRLKGYDGPVVECEKCSSEMHLKMGRFGKYMACTNESCGNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFRDRLPEKLRYLAEAPVTDPEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYVDGKWVESSR
(769) DNA topoisomerase 1 [Nitrosococcus watsonii C-113]
1
MSKNVVVVESPAKAKTIKKYLGKNFEVLASYGHVRDLMPKEGAVDPEHGFKMKYQAIEKNGRHVNAIAKALKSADSLLLATDPDREGEAISWHLLELLKEEGVLEDKAIQRVVFYEITSQAVNEAVAHPRDISLDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIDAFKVREYWTLEADAAAAKQPFVAKLTHLDGRKLTQFDIENKDQALALVERLTKAAAGELWVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSAKRTMSVAQQLYEGVDIGDGAMGLITYMRTDSVNLANEAVGEIRNFIAERFGQNSLPVKSRTFKTRAKNAQEAHEAVRPTSVYRVPEALKPYLKPEQFKLYQLIWRRTIACQMNHATIDAVAVDLDTQKAAPERGEDARGNIFRATGSTVVDPGFMAVYQEGRDDAKGEEEQRKLPPMKEGDRVALLQIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRDYTVLESKRFQPTDVGRVVNRFLTEHFNPYVDYDFTARLEDELDAISRGEKVWIPVLEEFWGPFSARIQEKEQNVSREEAVQARELGVDPQSSRPVSVRMGRYGPYIQIGSKEDEEKPRFAGLQPGQKMDAITLEEALALFKLPRELGFTPGGERVSVNIGRFGPYVKYDNKYVSLRGEDPHTIPLERALVLIEEKRQADANRVIKVFPDSGIQVLNGRYGPYVTDGERNVRVPKEQAPEELSLEQAQTLIHEAPVKRARRKAGSRKKAKG
(459) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(305) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFLPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEEIYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(348) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Gallinarum/pullorum str. RKS5078]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(192) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Gallinarum/pullorum str. RKS5078]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(985) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEERLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(867) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(771) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLSVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(226) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(205) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(386) DNA topoisomerase 1 [Xylella fastidiosa 9a5c]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPENGFAMRYDLIDKNEKHVEAITKAAKTADSIYLATDPDREGEAISWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRMIASDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFITREYWSIHAECAHPAQHFSAKLIKLDGQKFEQFTITDSDTAAAAQRRIQQVAQGRLHITDVTNKERKRRPAPPFITSTLQQEASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDIIARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVWKRAVASQMIPAILNTTSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPVMKTGENVPLERILTEQHFTQPPPRYTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVDMEGRSFRPTDIGRAVSKFLASHFTRYVDYDFTAHLEDELDAISRGEEEWIPLMKKFWVPFKELVEDKKDSLDKTDAGSVRLLGIDPTSGKEVSGRIGRFGPMVQIGTVDDEEKPRFASLRPNQSIYSISLEEAIELFKMPRVLGEDQSQQVSVGIGRFGPFAKRGSTYVSLKSEDDPYTIDLARATFLINEKEEIARNRIIKNFENSQIQVLNGRFGPYISDGKLNGKIPKDREPASLTLEEAQQLLIDTGKPARKNFSTKKTATKNETRKQTTKKRTTDAKATKKVSDKPVKKQIKKRIAPNITE
(1779) DNA topoisomerase [Xylella fastidiosa 9a5c]
4
MTRRSSAGRWSSCPLFRSSGGSRSNRRPPRNSKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTVLGLQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSVPFWAIDVSLSAGGQAFSAQWVPPDGCTDDAGRCLQQPIAQQAAQQIRAASSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRPIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETTARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIVQYGSTSLSIKVPQGPACPQCGAPTRQRTGKTGPFWSCSRYPDCKGTLPVDSGTSKRGASRPRSSGRKGS
(580) DNA topoisomerase 3 [Haemophilus influenzae R2846]
10
MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGDNDVVTWCVGHLLEQAEPDVYDPKFKQWRLEHLPIIPEKWQLLPRKEVKKQLSVVEKLIHQADTLVNAGDPDREGQLLVDEVFSYANLSAEKRDKILRCLISDLNPSAVEKAVKKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQTGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVQAWVNPESKEEKTPEKSTALFSALWQPSKACEDYQDDDGRVLSKGLAENVVKRITNQPAEVTEYKDVREKETAPLPYSLSALQIDAAKRFGMSAQAVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHNVLNAISTHCEAYQRLPNVISTEQRNRCWNDKKVEAHHAIIPTAKNRPIHLTQEERNIYSLIARQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQTAGWKELLGKEDDTENQEPLLPIVKKGQILHCERGEVMSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLTKKGRNIHSTETGRILIQALPDIATQPDMTAHWESQLTDISQKQATYQQFMHNLNQMLPDLVRFVDLNALRQLSRIKMIKSDRAKPKSAVKKSSKSNGQTD
(1866) DNA topoisomerase 1 [Haemophilus influenzae R2846]
9
MSKSLVIVESPAKAKTINKYLGSQYVVKSSVGHIRDLPTVGSSTGEKAKPISTKGMDAEEKAKIKAEKERNALVKRMGIDPYHDWKANYQILPGKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGNNDRFSRVVFNEITKNAIKQAFEKPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWEVAVLTNNQNKQAIRLDVTDYKGKKFDPKNQKEAQSAVDFLNVSDYVVTDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMARSYIENHFGAQYLPEKPNFYSSKENAQEAHEAIRPSDIRALPESLEGMEKDAVRLYDLIWRQFLACQMPPAQYDSSTLTVSAGDYTLKAKGRILRFDGWTKVLPQIGKNPEDQELPSVTVSEKLALKEVQPTQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNESFGELMNYDFTANMEDTLDKIASGSVNWKTELNQFFKDFSSQLSKAELDELEGGMRPNNLVETDIKCPTCDRNMAIRTASTGVFLGCTGYALPPKERCKTTINLIPEAELLNVLDESSETKALMDRKRCTKCGTAMDSYVIDAHRKIHICGNNPNCDGYLIEEGSFKIKGYDGPVVECDKCGADMHLKLGRFGKYMGCTNCDNTRKILKNGEVAPPKEEPVHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRPVKIAELVQYRERLPEKLAYLADAPQKDPEENEAIVRFSRKEKKQYVTSEKEGKATKWIVDFTNGKWVERKK
(213) DNA topoisomerase 3 [Haemophilus parainfluenzae T3T1]
10
MRLFIAEKPSLGRAIADVLPKPHQRGDGFIKCGNDDVVTWCVGHLLEQAEPDAYDPKFKQWRLEHLPIIPEKWILLPRKEVKKQLSVVEKLIHQADVLVNAGDPDREGQLLVDEVFSYANLSAEKRDGILRCLISDLNPSAVEKAVQKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQAGYDGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFYEVLAWVKEEKTSENPTALFSALWQPSKACEDYQDEDGRVLSLGLAENVVKRITDQPAEVTEYVDKREKETAPLPYSLSALQIDAAKRFGMSAQSVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHKVMNAISQHCQTYQTLPLVVDTEQRNRCWNDKKVEAHHAIIPTANTRSINLSIDEQRIYELIARQYLLQFCPDAEYRKSKIILSIAGGTFVAQARNLQTAGWKELLGKEDEDENQEPLLPIVKKGQILYCERGEVVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLTKKGRNIHSTETGRILISALPDIATQPDMTAHWEAQLTDISQKQASYQQFMFTLNQMLPDLVRFVDFTALRRLSQISKGLSTPATKRKRAVKKSEDLNAEN
(1632) DNA topoisomerase 1 [Haemophilus parainfluenzae T3T1]
9
MSKSLVIVESPAKAKTINKYLGSQYVVKSSVGHICDLPTAGSSTGEKAKPVSTKGLSAEEKNKIKAEKDRAALVKRMGIDPYHDWKANYQILPGKEKVVAELKSLAKKSDHVYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKKAIEKAFQHPAHINMDQVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEFWEIEALTQTSKKEDLRLDVVQYKGKKFEPKNEKEAQSAVDFLNKSHYVVTDLETKPTGSKPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMARSYIESHFGKDYLPAKPNFYSSKENAQEAHEAIRPSDVKMLADHLSGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVMAGDYELKAKGRILRFDGWTKVLPQLGKNPEDQILPAVSLNETLALKTVSPSQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRIENRRFYAEKMGEIVTDRLNQSFTDLMSYDFTANMENVLDQIASGEKNWKAELNQFFKDFSTQLSTAELDELEGGMKPNSLVLTDIDCPTCSRKMAIRTASTGVFLGCSGYALPPKERCKTTINLIPETELLNVLDEASETKALMDRKRCPICGTAMDSYIIDPHRKLHICGNNPNCDGYLVEQGQFKIKGYDGPIVECDKCGSDMHLKLGRFGKYMGCTNCDNTRKILKNGEVAPPKEEPVHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRPAKVAELALYRDRLPEKLRYLADAPQKDPEGNEAIIRFSRKEKHQYVTSEKNGKATKWIVDYIDGKWVERKK
(881) DNA topoisomerase [Haemophilus parainfluenzae T3T1]
4
MKLFLCEKPSQGNDIAKILGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFKKWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLAGFRGQIKRLWLSALDDASIRKALGALKDNEETLPLYYAGLARSRADWLIGMNFSRIYTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQYVIPEQYCDPDGLCLSAQVIQAANQQIRQLGQAKMESVETKRERQNAPLCFALSDLQSEANRLYGLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPKIIQCLLQSDNRLQPLAGMLNLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQFLPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQALPTLKQGQICQISDSEIKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQGLIDKGFLKKKGKSLLATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRHLMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFLGCSAYPNCQHIENFDSKKNTKGAKSSKKTSSKSVSEQISSLRSLLN
(481) DNA topoisomerase [Marinomonas posidonica IVIA-Po-181]
10
MILYIAEKPSLARAIAAALPGPQKKQEGCIWLPNGDCISWCIGHLLEQAEPHIYNPAFKTWQLDHLPIIPSDWQWQEKANTKKQLGILKKLIKQATQLVHAGDPDREGQLLVDEVLHYAKVPAQKLQQTQRVLISDLTPVAVKKSLQQLKSNAEFAALSRSALARARADWLFGLNLTRAYTIRGRQAGYQGVLSIGRVQTPVLGLVVARDTERENFVAKNYYQVWAQITTPENQHFQAKWLPSDACRPYMDEEGRVLNRALAKNVASRIENQPALVSQADYKQKKQPPPLPYNLSSLQIDAAKIFAMSAQQVLDTCQALYERHQIITYPRSDCRYLPTLQHRDAKAIINALSKGSEALAKSTKNANSNLKSKAWNDKQVTAHHAIIPTSQAHKAASLNKTESQIFGLIARQYLMQFYPDYQYLSTLIQLDIAGGKFEAKGSTPVALGWRSLLPTKKKSDHEEEQEQLPNLKKGDSLWCDQGIIRDKVTTPPAAFTDATLLAAMTGISRFVSDKSIKAILKETDGLGTDATRAGIIEILFKREFLIRQGKQIHASQTGRAFADTLPSQLVTPDMTAQWEAQLNAMSLGESRYQDFMAGLTDNLTDLLTQSKSVSTASLQHLPAPKRNPFKKRSATRKRSTKSKAKKPA
(1518) DNA topoisomerase 1 [Marinomonas posidonica IVIA-Po-181]
9
MGKSLVIVESPAKAKTINKYLGNDFVVKSSVGHIRDLPSGKTATSTPQERAKQAALTRKMSPEEKLEYKSRKSRKQLIARMGVDPEDNWHANYEVLPGKEKVVDELKRLAKNADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQSAFETPSELDLNRVNAQQARRFLDRVVGFMVSPLLWAKVARGLSAGRVQSVAVRLIVEREQEIRAFVPEEFWELDAMLSTSSDDMIKFEAAKYQGKEYRPVNQLQSDEHVARLQMAKYLVQSREDKPTKSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVESLRQYILSSFGEAYLPADPIRYSSKEGAQEAHEAIRPSDVNVRVDDLLGMEKDAHRLYDLIRSQFMACQMTPAEYTSTTITVVAEEYEFKAKGRILRFDGYTRAMQTVVKKGEDNILPDVTQGEFLDLKELLPEQHFTKPVARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGDIVTDRLVGSFSSLMDFSFTAQMEERLDEIAEGDKDWIQTLNAFYRDFSNVLAKAESPDDGMMLNEPTPTDVECPTCSRPMQIRTASTGVFMSCSGYALPPKERCKATINLIRGDEAVAVDDEEGESKALINKHRCKICGSAMDSYLMDEHRKLHVCGNNPSCTGYEVEAGSFKIKGYDGPVIECDKCSSEMQLKTGRFGKYFGCTNEECKNTRKLLKSGEVAPPKMDPVPMPDLACQKVEDHYVLRDGATGLFLAASQFPRKRETRAPYVKELIPYMDQIDPKYHFFADAPVADSEGRSTLIRYSRKTKEQYIMTENEGKPTGWKAFYDGGKWVIEEGKKKK
(716) DNA topoisomerase 3 [Actinobacillus succinogenes 130Z]
10
MRLFVAEKPSLARAIADVLPKPHSRGDGFIRCGENDYVTWCVGHLLEQAEPDAYNPSYKQWRLEHLPIVPQKWQLIPRKEVAKQLKIVEKLIHQADELVNAGDPDREGQLLVDEVFSYADLPADKKDKIQRCLVSDLNPNAVEKAVNKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQAGYNGVLSVGRVQTPVLGLIVRRDLEIENFRPKDFFEVLAQIKSEQNPTALSFTALWQPSKACEDYQDEDGRVLSRALAENVIKRITRQPAEVTAYEDKREKQTAPLPYSLSALQIDAAKRFALSAQDVLDTCQSLYEKHKLITYPRSDCRYLPNEHFADRHAVMNAISVHCTAYQTLPSAVNSEQKNRCWNDKKVEAHHAIIPTAKNRAVSLTAREQDIYGLIARQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQIAGWKELIGKEDDDEQLEAPLPVVKKGQMLFCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTEAGRILIQALPDLATQPDMTAQWEAQLNGISQKETSYQSFMFQLTQMLPELVQFVNFSALRRLSAVADRPKPTFKRKARKTADKSAVKSV
(639) DNA topoisomerase 1 [Actinobacillus succinogenes 130Z]
9
MSKSLVIVESPAKAKTINKYLGTNYVVKSSVGHIRDLPTAGASSGEKAKPISTKGLSVEEKSRIKAEKERNALVKRMGIDPYHDWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKNAIKQAFEKPEQLNIDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEFWEVAAELFTVHKAGIRLDVTAFKGKKFAPKNAEQAQSAVDFLAKSDFIVSDLETKPTSSRPRPPFITSTLQQAASTRLGFSVKKTMMLAQRLYEAGYITYMRTDSTNLSRDALGMVRGYIEQNFGDSYLPPKPNFYSSKENAQEAHEAIRPSDVNVSASHLSGMEKDAERLYDLIWRQFVACQMPAAQYDSTTLTVSAGDYELKAKGRILRFDGWTKVLPQMGKNPEDQELPAVALQEKLELGSVQPTQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFAELMNYDFTAGMEDMLDQIANGTKDWKAELNQFFKDFSGQLSQAELDELEGGMKPNSIVPTDIDCPACGRKMAIRTASTGVFLGCTGYALPPKERCKTTMNLIPESELLNVLDSETETKALMARKRCPKCGSAMDSYILDPHRKLHICGNNPNCDGYLVEEGAFKIKGYDGPVVACDKCGADMHLKLGRFGKYMACTNCDNTRRILKNGEVAQPKEEPIHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRESRPAEVAELALYRERLPGKLQYLADAPPKDPDGNDAVIRFSRKEKRQYVSSTDKNGKQTKWIVDFIDGKWIERSKK
(1604) DNA topoisomerase [Glaciecola sp. 4H-3-7+YE-5]
10
MILYIAEKPSLGRAIAQGFSGQQQKSDGYIKLANGDCVTWCIGHLLEQAEPDKYDPAYAKWALQHLPIVPQDWILVPKKGTSKQLSVIKRLLKTATKVINAGDPDREGQLLVDEVITYCKVKRDIIDNAGRLLINDLNLNAVKKSLTNIRPNREFTGLSISALARSRADWLYGLNLTRAYTLLGQRGGYSGVLSVGRVQTPVLGLVVRRDAEIAQFESKPFYDVIATLATQTSPSRQTFTAKWQPSAACEPYQDEEGRVIVKRLAETVVNKTRGQPGIVESYTVKDKQSPPPLPYNLSALQIDASKRYNLSPKAVLNVCQSLYERHQLITYPRSDSRYLPMEHFKDAQNVLSAIKANAPDQKSAVDNANSKLKSKAWNDSKVDAHHAIIPTSRRKALASLSGDEAKIYQLISTQYVMQFYGPHKYQEQVAVVTIAGGTFVAKAKATTDKGWLVLTKQSEAKQEPALPSLVKGQVLDCVDSQLVEKQTSPPKHFTEATLLAAMTGIARYVQDANIKKILKETDGLGTEATRASIIDLLFKRQFMQKSGKEIHATPTGKALVNALPSESTLPDMTAIWEANLDKISQRQMRYQDFMQPLTHTIGELINASQRIGTSQFAGLASTKPAYKKKWRKKKKAS
(829) DNA topoisomerase 1 [Glaciecola sp. 4H-3-7+YE-5]
9
MAKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGKVPPKKPAKELKLLSENKRESYLREHEYRKLVDRMGVDPKDDWAAHYEVLNGKEKVVNELKKLAKNADTIYLATDLDREGEAIAWHLQELIGDPSKDYQRVVFNEITKNAIQEAFSEPGKVNVERVNAQQARRFLDRIVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDVHANLLTAKDSDLRMQVAKYNDKAFKPTNKKQTDTALADLEGAEYKVISRDSKPTQSRPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSKEAVDACRDYIDDNFGAKYLPENALKYGSKEGAQEAHEAIRPSNVLLKSESLSEMERDAQRLYELIWRQFVACQMTPAKYDASTIRVSANGYELTAKGRVLKFDGWTKVQNPQRKKGEEDFLLPDVKEGESLSLKQLDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLESKRFYAEKMGEIVNDRLLENFDNLLSFDFTAKMEQELDEIANGKVSWKDVLNDFYGDFEKKLHLAEKDPDDGGMRLNQAVPTDIECPKCGRPMNVRTASTGVFLGCSGYNLPPKERCTGTMNLTSGDEVIKVDDEEELETELLRSKRRCPICSTAMDSYLVDETRKLHVCGNTPTCPGIEVEMGTFKIKGYDGPIIECDKCGSDMELKNGRFGKYFGCTNEECKNTRKLLRNGEAAPPKEDPVDLPELECTKSDAHFVLRDGASGIFMAAHNFPKSRETRAPLVAELARFRDRISPKFYYLADAPAKDPDGNDTLVRYSRKTKQQYVMSENEEGKATGWSAWYTDNKWTVEDKRKKAK
(721) DNA topoisomerase 3 [Glaciecola nitratireducens FR1064]
10
MIVYIAEKPSLGRAIATGFSGKQQKREGYIELDNGDCVTWCVGHLLEQAEPDKYDAAFAKWSLQHLPIVPDKWQLVPKKNTQKQLTVVKRLLKKATHIVNAGDPDREGQLLVDEVITYCGVKASIIENAGRLLINDLNTSAVKKALQNMRTNREFLGLSISALARSRADWLYGLNLTRAYTLLGQRGGYSGVLSVGRVQTPVLGLVVRRDQEIAHFVSKPFYEVIASLESQNKKTFNAKWQPSKACEPYQDEEGRVLSRKLAQTVVNKTRGQQAKVTDYKVQNRQSPPPLPFSLSVLQIEASKRFNLSPKMVLDVCQSLYEKHQLITYPRSDSRYLPKDQFGQASNVLGAIKSNVPNFASAVDNANPKLKSKAWNDSKVDAHHAIIPTNRSKAIGSFTQYEGKIYQLIANQYLMQFYGPHKYQEQVAKIDIAGGEFVAKGKSSQDLGWLALTKNQNNASDDNKNDTLLPQLNKGELLKCTDSQLMEKQTSPPKHFTEATLLAAMTGISRYVQDRNIKLILKETDGLGTEATRATIIDLLFKRQFMQKVGKEVHATETGKALINALPSETTYPDMTATWEADLDKIAQRQLRYDGFMQPLTESIARLIDNSQQLDSRQFAGLKSSKPTRKKRYFKKKSS
(763) DNA topoisomerase 1 [Glaciecola nitratireducens FR1064]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGLVEPKKPAKELSKWTDKKKAEYLKDYEYQKLVDRMGVDPKQNWMAHYQILQGKEKVVAELKKLAKDADTIYLATDLDREGEAIAWHLQELLGSKGKTYQRVVFNEITKNAIQEAFSDPGVVNINRVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDIHADLSTQKKDALKMLVAKHKGAAFKPINKKQADEAVSALENADYTVTSRESKPTQSRPSAPFITSTLQQAASTRLGYGVKKTMTMAQRLYEAGHITYMRTDSTNLSKDAVEGCRNYIQKNYGDKYFPSNPLTYGSKDGAQEAHEAIRPSNVAVKADSLKEMERDAQRLYELIWRQFVACQMTPAKYDATTIRVEANNYELTAKGRVLLFDGWTAVQPQIKRKGDNELLLPDVKQGDTLKLNELDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVKLDSKRFYAEKMGEIVNDRLVENFSDLISFDFTAKMEQRLDDIAHGETKWKSVLDNFYSEFSEQLENAEKSVEDGGMKLNQAVPVDIECSKCGREMNIRTASTGVFLGCSGYNLPPKEKCTNTMNLTPGDEVIKVDDEEELETEVLRAKRRCDKCGTAMDSYLVDENRKLHVCGNAPSCEGVFVEQGTFKIKGYDGPIIECDKCKSNMELKTGRFGKYFGCTNEECKNTRKLLRSGEAAPPKEDPVFLPELECEKSDAHFVLRDGAAGLFLAAHTFPKSRETRAPLVEELARFRDRISPKFYYLADAPKADPDKNPTIVRFSRKTKQQYVMSEDGKGKATGWSAWYENGKWVADDKRKKAKKEPKK
(1133) DNA topoisomerase 1 [Shewanella frigidimarina NCIMB 400]
9
MESIFFFSRLFGANKTMGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSTSDGTTVTKTAAEVKKLSPEEKAKYKLIRDKQALVARMGVNPDKGWAAKYQILPGKEKVVKELKALAETADQIYLATDLDREGEAIAWHLQEIIGGDPSRYQRVVFNEITKTAIQDAFSKPSVLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDIHAELNTPTAASLKMQVMKYQSAAFEPINEAQAKVAVDALRDATYVVTAREDKATSSKPSAPYITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSKEAVENLREMIAAEFGDKYLPAEPIRYGSKEGAQEAHEAIRPSNVAVQSASLTDMERDAQRLYELIWRQFVSCQMTPAQYDATRLTVTAGDYELKASGRTLRFDGWTRVQPQVSKKNEEDKTLPVVAKGDKLVLETLSPKQHFTKPAPRYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVDNRRFFAEKMGEIVSERLVGSFKELMSYDFTASMEQTLDDVAQGKLDWKKVLDGFYGDFTKQLLLAELDPDEGGMRPNEMVLTDDIKCPTCCRPMGIRTGSTGVFLGCSGYALPPKERCKTTLNLTPGEEAVSDNEDGETEALRAKHRCGKCGTAMDSYLIDETRKLHVCGNNPSCDGYEVEAGQFKIKGYEGPIIECDRCGNNMELKNGRFGKYFGCTNSECKNTRKLLRSGEAAPPKEDPIFLPELKCTKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVQYRDLLWPKYAYLADAPVEDDEGNKASVKFSRKTKEQYVATEVDGKATGWSSKFIGGKWVSESTKKKAKK
(1363) DNA topoisomerase 3 [Shewanella frigidimarina NCIMB 400]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFITAANGDCVSWCIGHLLEQAEPDAYDDAFKSWKLEHLPIVPQTWKLQPKPKTRSQLTVLRKLVKHASSIINAGDPDREGQLLVDEVISYLGVKGDKLNQVQRLLISDLNPQAVKRALGQLRKNREFVPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPLLGLVVRRDDEIADFTPKAFYEVLAHLLTDQQQAFTAKWQPSEACQPYMDEDGRVLAKGLAENVVARINDKPAEVTKIEAKDKRQNPPLPYSLSALQIDAAKRFGLSAKEVLDTCQSLYERHKLITYPRSDSRYLPKEQHALAPKVLDAVLKGASGLIEGCESPNSKLKSKAWDDSKVDAHHAIVPTEKVANLSTLSSNEAKLYQHVARQYLAQFYPAYIYAETAVEVTIAGGLFTTKARQDKTLGWKQLFKRTATVNQASSNSTSSDDDNDDAVLSLPPLVKGQILHCQRGELLQKMTQAPKHFTDATLLGAMTGISRYVTNSEIKKILKETDGLGTEATRAGIIELLFKRGYLVRQGKSILATPVGVGLIRSLPESATTPDMTALWENSLDAISQKRLKYDAFMQPLLSQLDGLITQASSQLPSALQGVASSAPKRSFKKSYKKKAKAKS
(71) DNA topoisomerase 1 [Alcanivorax borkumensis SK2]
9
MGKSLVIVESPAKAKTINRYLGDDFIVKSSVGHVRDLPVSGGSKKSTPQERAKEAAYTRSLPKEERDAYKKKKAKKQLINRMGIDPENGWAAHYEVLPGKDKVVDELKRLAAKADRIYLATDLDREGEAIAWHLREVIGGDEERFDRVVFNEITKKAIQAAFEEPGKLDLHRVEAQQARRFLDRVVGFMISPLLWEKIARGLSAGRVQSVAVELVVEREREIRAFIPEEFWELYSDTHSGDGEALRLQVAKHNGLAFRPNNGDDAAAHKQALENAGRLTISQREQRPTRSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSSDAVAACREWIGEKLGDKYLPDEPLSYSSKEGAQEAHEAIRPSDVRRTSDSLKDMERDAQRLYELIRRQFIACQMPPAEYLSSTLTAIGNGYELKAKGRIMKFDGWTRIQPPASRKGQEDTLLPDVKEGDVLAIDNVDANQHFTKPPARFTEASLVKELEKRGIGRPSTYAAIISTIQDRGYVRQDNRRFYAEKMGDIVTDRLVESFPNLMDYGFTASMEETLDEVAEGRRNWQDVLNEFYKDFVSKLDAAQGEGTGKQAVGGMRANLPTDTDIECPSCGRPMQIRTGSTGVFLGCSGYALPPKERCTATLNLLPGEEAEAVKTDDDEEAETNELRSKKRCQKCGTAMENYLIDEKRKLHICGNNPDCDGYVIEKGEFRIKGYDGPVLECEKCGNDMQLRTGRFGKFFKCTNDECGNTRKLLKSGEPAPPRADPIPMPHLQCQKVDDHYLLRDGASGLFLAASKFPKNRETRPPLIEEIQSVAEQLDPKHAYLAQAPATDPDGNKGVLRYSRKAKEQYVMSEIDGKATGWMAFYRDGKWVEEQAKKKAPAKKKAAAKKKATKKKAAAKK
(1519) DNA topoisomerase 1 [Kangiella koreensis DSM 16069]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSIGHIRDLPTGSQNKKPVDAKERARKAAATRKLSPEQKAKQKALKEKTALFARMGINPEHDWEARYEVLPGKEKVLNELKKFAKDADTIYLATDLDREGEAIAWHLRELLDGKETQFKRVVFNEITKKAIQQAFAKPGDLDMNYVNAQQARRFLDRVVGFMVSPLLWRKISRGLSAGRVQSVAVRLLVEREREIRAFIPEEYWDIHANTLTQSKDDLRLQVNKYQGKNFRPNSEQETNKALEVLKSSSYKVVTREDKPQKSKAPKPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTYLSTDAVDACRDYIKTNIGAEYLPKEANSYSSKEGAQEAHEAIRPSDVTKKVGHLSGMEKDAERLYDLIWRQFVACQMLPAEFDVTSLKVQAGDYELKARGRVMRFDGWTQVLPMQKKNAEDEELPNVKEGELLELKKLDPKQHFTKPPARFSEAALVKELEKRGIGRPSTYASIISTIQDRGYVRIENRRFYAQKIGEIVTDRLVESFSDLLDFSFTATMEKHLDDIASGRQNWKVTLDEFYDEFSQQLKKADEEEGEGGMRRNEAVETDILCDKCKKNHMAIRNASTGVFLGCMGYSLPPKERCKNTVNLIPGEEFIAADEEEEARYLHDKKRCTKCNSTMDDYLVDENTKLYICGNNPDCDGYEIEKGEFKIKGYDGPILECDKCGSEMQLKTGRFGKYFDCTNDDCKNTRKLLKSGQPAPPKADPIPMPELQCEKVDDHYVLRDGAAGIFLAASKFPRNRETRAPAVDELVTVKDKLDPKYKFLGEAPLKDPDGNRTFVKFSRKTGQQYVAGVKEDGKASGWTAFYENGKWVPQK
(33) DNA topoisomerase 1 [Hahella chejuensis KCTC 2396]
9
MTAISTRSKEPSAMGKSLVIVESPAKAKTINKYLGSEYVVKSSVGHIRDLPTSGGKETSSPKERAAEAAKMRKLPAEERESIKKRKARDQLISRMGVDPENDWAARYEVLPGKEKVVEELRRLAKSADQIYLATDLDREGEAIAWHLKESIGGDDSRYRRVVFNEITKSAITEAFKSPGQLDYNRVNAQQARRFLDRVVGYMVSPLLWSKIARGLSAGRVQSVAVRLIVEREREIRAFTPEEYWELHALLSKSKQQAKFQVAKYKGENYRPTNKAQSDKLTALLQTQAFKVVNREDKPSVTKAPAPFITSTLQQAASTRLGFSVKKTMVLAQRLYEAGYITYMRTDSTNLSADAVNACREFIGKKFGDKYLPDNPKTYVSKERAQEAHEAIRPSDINVGANQISGLEKDAEKLYDLIWRQFVACQMENARFLSTSIQVQAGDFELRTRGRLLQFDGFLKVLPAQAKKDDEAELPAFEVNDQLDLDKLEPTQHFTKPAPRYTEATLVKELEKRSIGRPSTYASIISTIQERGYVKLANRRFYAEKMGDIVTDRLTEAFTDLMDYGFTAKMEGQLDEIASGNEGWKQVLNAFYSDFAKKLEKADMEGGMRANQAVQTEIACPTCSRPMQIRTASTGVFLGCSGYALPPKERCKTTINLIPGDEVIRADDEEGEANALRAKKRCPICDTAMDSYVIDETRKLHVCGNNPDCEGYEVEGGQFKVAGYDGPTLECDKCGAEMQLKTGRFGKYFGCTSSTCGNTRKLLKNGEPAPPKMEPVVMPELACDKVDDIFVLRDGASGLFLAASKFPKNRETRAPLVEELIPHKKEIDPKHHYLLEAPTRDPEGNPAIIRFSRKTKQQYVMSEKGGKPTGWSAFYKDGKWVAKDK
(1721) DNA topoisomerase 3 [Shewanella woodyi ATCC 51908]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGHIIAGNGDCVSWCIGHLLEQAEPDAYDPEFKSWKFEHLPIVPDSWKMKAKPKTRSQLTILKGLIKQASQLVNAGDPDREGQLLVDEVIAHFGVKGDKLHQTKRLLISDLNPQAVKRALGQMRSNREFIPLSTSALARSRADWLYGLNMTRAYTIQGRKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFVSKPFFEVLANLSTEHNEHFKAKWQPSEACQAYMDEEGRVLSKGLAQNVVGRITEQPACVVGLDSKDKKQNQPLPYNLSSLQIDAAKRFGMSAKEVLDTCQALYEKYKLITYPRSDSRYLPIEQFSMAPSVIKAVLSGASELVIGPEQPDSKIKSKAWNDKKVDAHHAIIPTEKTANLAGLTPRERQIYLQLARQYLAQFYSPYQYHETLVEVEIAGGKFKTKAKQDKSLGWKQLFAKKGEKLEEKGSAVGDSSDDDLDALQKLPQLKKGQALHSGQGELIEKQTQAPKHFTDATLLGAMTGINRYVTDPEIRKILKDTDGLGTEATRAGIIELLFKRNYLSRSGKSIVATDVGKGLINSLPMSATTPDMTALWESNLDAISRKEAKYINFMSPLVDSLAQLITQAGAQLPTSLQGIKAPKSNFKKRAYSRKKTTKSAAKPSGRRATKVS
(342) DNA topoisomerase 1 [Shewanella woodyi ATCC 51908]
9
MEPIYKFLRLFGADHSMGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSTAEANVATKTPAEVRKMSPEEKAIYKSKRAKQALVTRMGVDPENGWKAKYQTLPGKEKVVKELQALAASADHIFLATDLDREGEAIAWHLQEVIGGDASRYQRVVFNEITKSAIQDAFSKPATLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEKEGEIKAFVPEEFWDIHANLTTLANDALKMEVVKFQEKAFNPVNELQAQTAVSALSQSSFVVAAREDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVDNVREMIGKEYGDKYLPDAPIRYGSKEGAQEAHEAIRPSDVSVHAAGMKDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGEYELKATGRTLRFDGWTRVQTAVKKKNEEDNTLPVVAKGDVLSLEELLPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLIGSFKELMSYDFTASMEQTLDDVAQGELEWKKVLDGFYQDLTKQLDQAELAPEEGGMRPNEMVLTDIKCPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTAGEEAVSENSEDAETDALRAKHRCGVCGTAMDSYLIDETRKLHVCGNNPICGGYEVELGQFKIKGYEGPIIECDRCSNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFMAASTFPKSRETRPPLVEELVKYRELLWPKYAYLADAPVEDDDGNKSTVRFSRKTKEQYVATEVDGKATGWTSKFVDGKWVTESKKKAKPKAKPKAKAKAKS
(907) DNA topoisomerase 3 [Shewanella amazonensis SB2B]
10
MRPPGIFATFTVNSSSAFAPEYPAMILYIAEKPSLGRAIAEVLPKPHKKGEGYIELGNGDCVTWCIGHLLEQAEPDAYSPEYKQWQLAHLPIIPAEWKLTPRSSAKSQLAVVKRLIKQASSLVHAGDPDREGQLLVDEVISHAKVSASKLASTQRLLISDLNPDAVRRALGQLRSNKEFVPLATSALARSRADWLYGLNMTRAYTLQGRKVGYAGVLSVGRVQTPLLGLVVRRDLDIEHFEPKDHYEVLAHITTDKGESFCAKWQPSEACQPYMDEEGRVLSRRLAETVVSRIGGKPALVEHVSHKDKKQAPPLLYSLSALQIDCAKRFGMSAKEVLDTAQSLYERHKLITYPRSDSRHLPKEQLALVPDVLSAVSANAPELLEGAPSPDLHLVSKAWDDSKVDAHHAIVPTGKRTALSQLNQRERQLYLHIARQYLAQFYPNRLLADTEIQLIIEGGSFIARASVERAPGWRVLFQGRSTEQDEAKEPQETDASQKTPLPALNKGDIARCCHGELLAKQTQPPKHFTDATLLSAMTGIARYVSSPDIKRILKDTDGLGTEATRAGIIELLFKRGFLVRQGKSIVASQAGRGLIASLPEVATTADMTALWERQLSDICQRQLSYKGFMTPLVLELEKLIEQAAASLPTALAGVTAAGPKRSFRGRAGKGKGRAPGASAGRGRKSRSSPSGKVAT
(1421) DNA topoisomerase 1 [Shewanella amazonensis SB2B]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSAAEGKASTKSAAEVRKMNPEEKAKYKAQKDKQALVARMGVDPEHGWQANYQVLPGKEKVVKELQSLASSADQIYLATDLDREGEAIAWHLQEVIGGDESRYKRVVFNEITKGAIQEAFSRPTDLNTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREAEIKAFVPEEFWDVHATLSTPAAAELVMEVSRYRNEAFEPVTQSEAMAAVNALEKAAFTVTDREDKATSSKPSAPFITSTLQQAASTRLGFGVKKTMMLAQRLYEAGHITYMRTDSTNLSQEALENVRAHIEKEFGSKYLPESPIRYGSKEGAQEAHEAIRPSNVKVESATLIDMERDAQRLYELIWRQFVACQMTPAVYDATRITAKAGDYELKASGRILKFDGWTRVQPALKKKNEEDNTLPDVQVGDMLSLKALDPKQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVKVENRRFYAEKMGEIVTERLVESFSELMNYDFTAGMEQTLDDVAKGDKDWKGVLDGFYSGFTAKLEKAEAEPDAGGMRPNQMVLTDIPCPTCGRQMGIRTGTTGVFLGCSGYALPPKERCKTTLNLTPGEEAISDSSEDAETDALRAMHRCGKCGMAMDSYLLDETRKLHVCGNNPECDGYEVEKGAFKLKGYEGPIIECDRCGSDMELKNGRFGKYFGCTNESCKNTRKLLKNGEAAPPKEDPIHLPELKCTKSDAYFVLRDGAAGIFLAASTFPRSRETRAPLVEELKKYREALWPKYQYLADAPVEDAEGNKALVKFSRKTKEQYVATEVNGKATGWSAHFKDGKWVESK
(713) DNA topoisomerase 3 [Shewanella oneidensis MR-1]
10
MILYIAEKPSLGRAIADVLPKPHKKGEGFIEDANGNCVSWCVGHLLEQAEPDAYNPDFKSWKFEHLPIVPEKWQLKPKAATRSQLTVLKKLIKQADTLVNAGDPDREGQLLVDEVIAYLGVTGDKLQQTQRLLISDLNPQAVKRALSQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLIVRRDEEIAHFQSKPFYEVLAHLVTDKQQFFSAKWQPSEACQPYMDDEGRVLSKGLAQNVVRRITDKPAKVTQLSTKDKQQSAPLPYSLSALQIDAAKRFGMSAKEVLDTCQSLYERHKLITYPRSDSRYLPTEQHGLASSVLNAITSGAPELVAHSEAPNPRLKSKAWDDKKVDAHHAIIPTEKQPNLGSLSQRERQLYLHIARQYLAQFYPAYCYSETAVEVTIEGGLFKTKARQDKSLGWKQLFAREEGERKDTSNTETFAQDDKDKDEGEYAGQLPPLILGQVLHCNQGELVEKQTQPPKAFTDATLLGAMTGINRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFIQRQGKSIVATEVGKGLINSLPLSATTPDMTALWEASLNGICHKDISYQGFMQPLLGTLHSLIQNAGAQLPSALNGLKGQGFKRAATKKSGYRKAGVRGAAGGKKAGTGAKNARNSAAASSTSTTAKPTVPRRRTSKATAQA
(1060) DNA topoisomerase 1 [Shewanella oneidensis MR-1]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSISDGTEKVKSAAEVKKMSPEEKARYKKVKDHQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQEAFSKPASLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAQLNTPSSEALRMEVVKYLDSAFEPTNEQQALAAVQALSSASFKVIAREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDSVREMIGKEYGAKYLPAEPIRYGSKEGAQEAHEAIRPSNVKVEAAALTDMERDAQRLYELIWRQFVSCQMTPALYDATKLTVKAADYELKATGRILRFDGWTRVQTAIKKKNEEDNTLPAVNEGDVLSLVELEPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQERGYVKVENRRFYAEKMGEIVSERLVNSFAELMSYDFTASMEQTLDDVAKGELDWKKVLDGFYADFTKQLEKAELAPEEGGMRLNQMVMTNIKCPTCGRPMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGIEAISDSEDAETDALRAKHRCGICGTAMDSYLLDEKRKLHVCGNNPVCEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNEECKNTRKLLKNGEAAPPKEDPIYLPELKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYREFLWPKYQYLADAPIADDDGNKAVVKFSRKTKDQYVATEVDGKATGWSAHYVNGKWVSESSAKKAKK
(1252) DNA topoisomerase 1 [Nitrosococcus halophilus Nc 4]
1
MSKNLVVVESPAKAKTIKKYLGKDFEVMASYGHVRDLMPKEGAVDPEHGFAMKYQVIEKNSRHVDAIAKALKKADALLLATDPDREGEAISWHLLELLKERGALEGKSIKRVVFYEITQQAVNEAIAHPRDISSDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIEAFKIQEYWTLEADAAASKHPFVAKLTHLDGHKLGQFDIDNGDRAQALVEQLTKAASGELLVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSTKRTMSVAQQLYEGVDIGDGAVGLITYMRTDSVNLANEAVKELRDFIAGHFGEKSLPAKPKTFKTRAKNAQEAHEAIRPTSVYRTPEELKPHLKPEQFKLYQLIWRRTIACQMNHATIETVAVDLDTRKSVPEKGVSNTGSNIFRATGSTVVDPGFMAVYQEGRDDTKAEEEQRILPPMKEGDRVELVRIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRSYALLENKRFHPTDVGRVVNRFLTEHFNPYVDYDFTARLEDQLDAISRGEKVWIPVLEEFWEPFLGRIQEKEQSVSREEAVQARELGIDPKSGRPVSVRIGRYGPYVQIGSKEDEEKPRFAGLRPGQKMDTITLEEGLALFELPRELGFSPEGEKVSVNIGRFGPYVKYDNKYVSLRGEDPYTIALERALELIQEKKQADANRVIKVFPDSGIQILNGRYGPYVTDGERNARVPKDQAPEKLSLEQAQTLINEAPAKRARRKTGTRKKAKG
(587) DNA topoisomerase 1 [Brucella microti CCM 4915]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1296) DNA topoisomerase 3 [Shewanella sp. W3-18-1]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFIEAANGDCVSWCVGHLLEQAEPDAYNPEFKAWKFEHLPIVPDKWQLTPKAATRSQLTVLKRLVKQASMLVNAGDPDREGQLLVDEVIAYLGVTGDKLHQTQRLLISDLNPQAVKRALTQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDKEIANFQSKPFYEVLAHLATDKQETFSAKWQPSEACQPYMDEEGRVLARGLAQNVVSRISDKPALVTQLVAKDKKQHPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPVEQHNLAPSVLKAISDGAAELLQGADAPDPRLKSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHIARQYLAQFYPAYCYSETTVQVTIEGGLFNTKARQDKSLGWKQLFARQEPNGSKASGNKSTEESAGKDDEEHDEFIGQLPPLKLGQALHCTRGELLEKNTQPPKAFTDATLLSAMTGISRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVSTDVGKGLINSLPLSATTPDMTALWEASLNGICHKETSYQGFMQPLLGTLSTLIQNAGAQLPTALNGLKGQGYRKTASHKSGYRKSYSKKSSSAKGIGTTKNDVSNKYGSQKTSSKSSVTRSTSRSASNSRKSTAAV
(1556) DNA topoisomerase 1 [Shewanella sp. W3-18-1]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSEGNEKVKSAAEVKKMSPEEKAQYKKVKDQQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAQLTTPAEESLRMEVVKHLDSAFEPINEQQALAAVQALSSASFKVISREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALESVRDMIGKAFGAKYLPAEPIRYGSKEGAQEAHEAIRPSNVHVEATDLTDMERDAQRLYELIWRQFVSCQMTPAQYDATKLTVKAGDYELKATGRTLRFDGWTRVQTVLKKKNEEDNTLPFVSQGDVLALKELQPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSERLVSSFADLMSYDFTASMEQTLDDVARGELDWKKVLDGFYADFTKQLEKAERDPEEGGMRLNQMVMTDIKCPTCGRPMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGVEAISENSEDAETDALRAKHRCGICGTAMDSYLIDEKRKLHVCGNNPICEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNEECKNTRKLLKNGEAAPPKEDPIYLPELKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPICDDEGNKAAVKFSRKTKEQYVATEVDGKATGWSAHYINGKWVSESTAKKSKKA
(823) DNA topoisomerase 3 [Shewanella loihica PV-4]
10
MILYIAEKPSLGRAIADVLPKPHKKGEGYITAANGDTVSWCIGHLLEQAEPDSYDPAFKSWSFDHLPIVPQQWKMTPKSKTRGQLSVLRKLVKQASQLVNAGDPDREGQLLVDEVIAYLGVKGDKLEQTQRLLVSDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTLQGRKVGYQGVLSVGRVQTPLLGLVVRRDEAIEHFVSKPFYEVLANLYTQEQAHFKAKWQPSEACQPYMDEEGRVLSRRLAENVVGRITEQPAKVTDLQAKDKQQGQPLPYNLSSLQIDAAKRFGMSAKTVLDTCQSLYEKHKLITYPRSDSRYLPKEQLALAPSVIGAVLKGAGELTAQCAAPDLKIVSKAWNDAKVDAHHAIVPTEKVANLSALTQAEKQIYLQLARQYLAQFYPVYRYHETQVEVEIAGGHFHTKAKQEIALGWKQLFPKRSDDKTDGEGDEALAQLPPLHKGQMLHSGQGELIEKQTQPPKAFTDATLLSAMTGISRYVTNPEIRKILKETDGLGTEATRAGIIELLFKRGFLARQGKSIVSTPVGRGLINSLPESATTPDMTALWESHLDAISRKEAKYLSFMAPLVESLNGLIMQAGAQLPKALQGVEAPKRSFKKRGYGNRRGTATGAKGKASGAKKTAARAASKTRAKTSA
(325) DNA topoisomerase 1 [Shewanella loihica PV-4]
9
MEPIYRILRLFGADHSMGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSSSDASSSTKSPAEVRKMSTEEKAKYKADKAKKALVARMGVDPERGWKAKYQTLPGKEKVVKELQSLAENADHIFLATDLDREGEAIAWHLQEVIGGDPERYQRVVFNEITKSAIQEAFSHPSQLNTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEREGEIKAFVPEEFWDIHAELTTLGNEGLKMQVAKFKGDNFNPVNEAQAMVAVNALKDSKYQVSSREVKATSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDSVRDMIGKEYGDKYLPDAPIRYGSKEGAQEAHEAIRPSDVNVSATSLSDMERDAQRLYELIWRQFVACQMTPAKYDATRLTVTAGDYELKASGRTLKFDGWTRVQTALKKKNEEDNTLPMVAEGDVLALEELLPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLIGSFEELMSYDFTAGMEQTLDNVAQGQLEWKKVLDNFYKGLTAQLEKAELPPEEGGMRPNEMVLTDIACPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSENSEDAETDALRAKHRCDVCGTAMDSYLIDEKRKLHVCGNNPICGGYEVEQGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNSECKNTRKLLKNGEVAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPVADEDGNKAVVRFSRKTKEQYVATEIDGKATGWTAKFVGGKWVSEAKAKPKAKKKA
(522) DNA topoisomerase 3 [Shewanella piezotolerans WP3]
10
MILYIAEKPSLGRAIADVLPKPLKKGEGFIRAANGDCVSWCVGHLLEQAEPDAYSPEYKSWKFEHLPIVPDVWKMKPKYKMRGQISVLRGLVKEATQLVNAGDPDREGQLLVDEIIAHLGVKGNKLTQAKRLLISDLNPQAVKRALGQLRLNREFIPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPILGLVVRRDEEIAHFVSKPFFEVIAHLTAEPQQTFTAKWQPSEACQPYMDEDGRVLSKGLAQNVVGRITGQPATVEKVNAQDKKQNAPLPYNLSSLQIDAAKRFGMSAKTVLDTCQSLYERHKLITYPRSDSRYLPQEQHGMAPSVINTVNKGAPELTQGIDAPNAKLKSKAWNDKKVDAHHAIIPTEKVANLSSLSPAEKQVYLLVARQYLMQFYSAYQYKETQVEIIIAGGLFKTKAKQEIAKGWKLLLKQSKASTSSDSNGQDEDELATIPPLTIGQKLFCDRGQLLEKQTQPPKHFTDATLLSAMTGISRFVTDVEIRKILKDTDGLGTEATRAGIIELLFKRSFLVRQGKTIVATDVGKGLINSLPLSATTPDMTALWENNLDSMSRKETQYQAFMQPLISKLDELITQAGSVLPTALQGVKSPTPFKKKSYARKGGKGQSTTKKNVGKPRMAKS
(854) DNA topoisomerase 1 [Shewanella piezotolerans WP3]
9
MEPIFRFLKLVGANKYMGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSSPDAKVVSKTPAEVKKMSPEEKAEYKSLKAKQALVARMGVDPEKGWKAKYQTLPGKEKVVKELQTLAESADHIYLATDLDREGEAIAWHLQQVIGGDESRYQRVVFNEITKSAIQDAFSQPSVLDTNMVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVRLVVEREGEIKAFVPEEFWDVHAELNTLCDERLKMQVAKFQGKAFNPVNQTEADAAVSALSQSSFVVAGREDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVREMIGKEYGDKYLPEAPIRYGSKEGAQEAHEAIRPSNVKVTAASLSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVAAGDYELKASGRTLRFDGWTRVQTAIKKKNEEDNTLPVVAKGDTVTLQELMPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVDNRRFYAEKMGEIVSDRLVGSFQDLMSYDFTASMEQTLDDVAQGKLDWKKVLNGFYKDFTKQLENAELPPEEGGMRPNEMVITDIKCPTCGRPMGIRTGSTGVFLGCSGYALPPKERCKTTLNLTPGEEAVSESGEDAETEALRAKHRCGICGTAMDSYLIDETRKLHICGNNPTCEGFEVEAGQFKIKGYEGPIIECDRCQNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPDLKCTKSDAYFVLRDGAAGIFLAASTFPKSRETRGPLVEELVKYRELLWPKYAYLADAPVADDDGNLASVRFSRKTKEQYVATDVDGKATGWTAKFIDGKWVAEAKAKAKPKAKAKPKAKPKAKAKPKAE
(629) DNA topoisomerase 3 [Shewanella baltica OS155]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFIEAANGDCVSWCVGHLLEQAEPDAYNPEFKSWKFEHLPIVPDKWQLKPKAATRSQLTVLKRLVKQANTLVNAGDPDREGQLLVDEVIAYLGVTGDKLHQTQRLLISDLNPQAVKRALTQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFQSKPFYEVLAHLATEKQETFSAKWQPSEACQPYMDEEGRVLARGLAQNVVSRISDKPALVTQLVAKDKKQNPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPVEQHSLAPSVLKAISGGAAELLQGADAPDPRLKSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHVARQYLAQFYPAYCYSETTVQVTIEGGLFNTKARQDKSLGWKQLFARQEPNGSKASGNKSTEENAGKDDEENDEFIGQLPPLKLGLALHCTRGELLEKNTQPPKAFTDATLLGAMTGISRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVSTDVGKGLINSLPASATTPDMTALWEASLNGICHKETSYQAFMQPLLGTLSTLIQNAGAQLPTALNGLKGQGYRKTAGNKSGYRKSPYRKASSSAKRTGTASTAKTSTTTSSSAKKSSASSGTRSRTRKVAAEV
(1232) DNA topoisomerase 1 [Shewanella baltica OS155]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSEGNEKVKSAAEVKKMSPEEKAQYKKVKDQQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAELSTPAQEALRMEVVKHLDAAFNPINEQQAMAAVQALSAASFTVLAREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVENLRDMIAKEFGDKYLPAEPIRYGSKEGAQEAHEAIRPSNVHVQAATLSDMERDAQRLYELIWRQFVSCQMTPAQYDATKLTVKAGDYELKATGRTLRFDGWTRVQTALKKKNEEDNTLPFVAQGDVLALKELQPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSERLVGSFADLMSYDFTASMEQTLDDVARGELDWKKVLDGFYADFTKQLEKAELDPEEGGMRLNQMVMTDIKCPTCGRSMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGVEAISENSEDAETDALRAKHRCSICGTAMDSYLIDEKRKLHVCGNNPICEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNSECKNTRKLLKNGEAAPPKEDPIYLPDLKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVQYRELLWPKYQYLADAPVTDDEGNKAAVKFSRKTKEQYVATEVDGKATGWSAHYVNGKWVSETTKKAKKSA
(987) DNA topoisomerase 3 [Shewanella pealeana ATCC 700345]
10
MILYIAEKPSLGRAIADVLPKPLKKGDGFIRAANGDCVSWCVGHLLEQAEPDAYSPEYKSWKFEHLPIVPETWKMKPKYKMRGQIAVLRGLVKEASQLVNAGDPDREGQLLVDEIIAHLGVKGPKLQNAQRLLISDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPVLGLVVRRDAEIAEFISKPFYEVLAHLATDNQQRFSAKWQPSEACQPYMDEEGRVLSKGLAQNVVGRINGQNGTVEKVTAQDKKQNAPLPYSLSALQIDAAKRFGMSAKSVLDTCQSLYEKHKLITYPRSDSRYLPAEQHALAPSVIGAVLNGASELVSGIEQPNSKLKSKAWNDKKVEAHHAIVPTEKTANLQNLNQAEKQLYLQVARQYLMQFYPAYLYKETQVEIIIAGGLFKTKAKQEVALGWKQLLKQNKEKSQSEKQQTDDDEYLANIPALKKGQILLCERGELLEKQTQPPKHFSDATLLGAMTGISRYVTDSEIRKILKETDGLGTEATRAGIIELLFKRNYLTRQGKSILATEVGKGLINSLPLSATTPDMTALWENNLDAISRKEAKYQSFMAPLLISLQQLIEQAGAQLPTSLQGVKSPDSGFKKRRYSGNKSAATTKSATAKKASAKRVSTTKAKRATS
(740) DNA topoisomerase 1 [Shewanella pealeana ATCC 700345]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSSSDAKVVSKTAAEVKKMSPEEKAEYKSLKAKQALVARMGVDPEKGWKANYQTLPGKEKVVKELQTLAASADHIYLATDLDREGEAIAWHLQQVIGGDESRYQRVVFNEITKTAIQDAFSQPSVLDTNMVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAELNTLTDDLLKMQVVKFQGKAFSPVNEVEAQTAVSQLSQSSFVVAAREDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVRDMIGKEYGDNYLPESPIRYGSKEGAQEAHEAIRPSNVKVSAASLSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGDYELKATGRTLRFDGWTRVQTAIKKKNEEDNTLPYVAQGDAVTLKELLPKQHFTKPAPRYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVDNRRFFAEKMGEIVSDSLVGSFEDLMSYDFTASMEQTLDDVAQGKLEWKKVLDGFYKDFTKQLEVAELPPEEGGMRPNEMVITDNIKCPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTLNLTPGEEAVSSGEDAETEALRAKHRCGICGTAMDSYLIDEARKLHVCGNNPTCNGYEVEAGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNTECKNTRKLLRSGEAAPPKEDPIHLPELKCTKSDAYFVLRDGAAGIFLAASTFPKSRETRGPLVEELVKYRELLWPKYQYLADAPVADDDGNLASVRFSRKTKEQYVATDVDGKATGWTSKFVDGKWVTEAKAKPKPKAKAKPKAKPKAKATKAE
(696) DNA topoisomerase 3 [Shewanella sediminis HAW-EB3]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGHIMAANGDCVSWCIGHLLEQAEPDHYDPLFKSWKFEHLPIIPQQWKMKAKPKTRSQLTVLRGLVKKASQLVNAGDPDREGQLLVDEVIAHLGVKGEKLNNTQRLLISDLNPQAVKRALGQMRSNREFIPLSTSALARSRADWLYGMNMTRAYTLQGRKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFVSKPFFEVLANLTTDNKEAFKTKWQPSAACQPYMDEEGRVLAKGLAQNVVGRITNKPAEVTQVLAKDKKQNAPLPYSLSSLQIDAAKRFGMSAKEVLDTCQTLYERHKLITYPRSDSRYLPVEQFQQASQVVSAVSSGAAELLEGMTAPDTKIKSKAWNDKKVDAHHAIIPTEKTANLSQLGARERQIYLQVARQYLAQFYPPYLYSETEVHVLIEGGNFKTKAKQERALGWKQLFGRNSDKQKSNGPDSKNNSDDDEESSQVLPPLVKGQQLHSGMGELVEKHTQAPKHFTDATLLGAMTGISRYVTDPEIRKILKDTDGLGTEATRAGIIELLFKRSFLSRQGKSILSTEVGQGLINSLPMSATTPDMTALWESNLDAICRKEAKYLSFMSPLIASLSELITQAGSQLPSALQGVKAPANSFRKKRYSKSLGSGRKKSTTGSTSRTSATKKRASSKTQTKG
(1874) DNA topoisomerase 1 [Shewanella sediminis HAW-EB3]
9
MGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSSTEAKVATKTPAEVRKMAPEEKAIYKSIKAKQALVSRMGIDPDKGWKANYQTLPGKEKVVKELQKLAESADQIFLATDLDREGEAIAWHLQEVIGGDASRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEKESEIKAFVPEEFWDIHAQLETLNNAALKMQVVKFQDKAFNPVTESQAQTATSALSQSSFVVAARDDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDGVREMIAKEFGDKYLPEAPIRYGSKGGAQEAHEAIRPSDVSVQAASMKDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGEYELKATGRTLRFDGWTRVQTVVKKKNEEDNTLPVVAQGDKLNLQELMPKQHFTKPPARYGEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLVGSFKELMSYDFTASMEQTLDDVAQGELKWKKVLDGFYKDLTKQIEQAELAPEEGGMRPNEMVLTDNIKCPTCDRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSENSEDAETDALRAKHRCDVCGTAMDSYLIDEKRKLHVCGNNPICGGYEVEQGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNDDCKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFMAASTFPKSRETRAPLVEELVKYRELLWPKYAYLADAPVTDDDGNKATVRFSRKTKEQYVATDVDGKASGWASKFIDGKWVSESKKKAKPKAKAKPKEKK
(1369) DNA topoisomerase 3 [Shewanella halifaxensis HAW-EB4]
10
MILYIAEKPSLGRAIADVLPKPLKKGDGFIRAANGDCVSWCVGHLLEQAEPDAYSPEYKSWKFEHLPIVPDNWKMKPKSKMRGQIAVLRGLVKEATQLVNAGDPDREGQLLVDEIIAHLGVKGAKLQNAQRLLISDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPVLGLVVRRDGEIAEFVSKPFYEVFAHLATDNQERFSAKWQPSEACLPYMDEEGRVLSKGLAQNVVGRINGQPATVEKVTAQDKKQNAPLPYSLSALQIDAAKRFGMSAKAVLDTCQSLYEKHKLITYPRSDSRYLPVDQHGLAPSVIRAVLSGASELVSSCDEPNAKLKSKAWNDKKVDAHHAIVPTEKTANLSNLSQAEKQLYLQIARQYLMQFYPAYLYKETQVEIIIAGGLFKTKAKQEVALGWKQLLKLSAKASQEKSSSEKSQTDDDEHLANIPALKKGQILLCERGELLEKNTQPPKHFTDATLLGAMTGISRYVTDSEIRKILKDTDGLGTEATRAGIIELLFKRNYLTRQGKSILATEVGKGLIYSLPQSATTPDMTALWENNLDAISRKEAKYQSFMDPLVNSLQGLIEQAGSQLPTSLQGVKSPDGGFKKRRYSGKKSTTTTKSAIANKTPAKRASTAMTKTKKATS
(984) DNA topoisomerase 1 [Shewanella halifaxensis HAW-EB4]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSSSEAKVVSKTAAEVKKMSPEEKAEYKSLKAKQALVARMGVDPENGWKAKYQTLPGKEKVVKELQTLAASADHIYLATDLDREGEAIAWHLQQVIGGDESRYQRVVFNEITKSAIQDAFSQPSVLDTNMVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAELNTLTDDLLKMQVVKFQGKAFNPVNETQAQTAVSQLSQSSFVVAAREDRATSSKPSAPYITSTLQQAASTRLGYGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVRDMIAKEYGDKYLPESPIRYGSKEGAQEAHEAIRPSNVKVSAASLSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGDYELKATGRTLRFDGWTRVQTAIKKKNEEDNTLPYVAQGDAVTLKELQPKQHFTKPPARFSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSDSLVGSFQDLMSYDFTASMEQTLDDVAQGKLEWKKVLDVFYKDFTKQLEIAELPPEEGGMRPNEMVIADDIKCPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTLNLTPGEEAISEGGEDAETEALRAKHRCGICGTAMDSYLIDEKRKLHVCGNNPTCNGYEVEAGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDAYFVLRDGAAGIFLAASTFPKSRETRGPLVEELIKYRELLWPKYQYLADAPVADDDGNLASVRFSRKTKEQYVATDVDGKATGWSSKYIDGKWVTEAKAKAKPKAKAKPKAKAKKAE
(1636) DNA topoisomerase 1 [Teredinibacter turnerae T7901]
9
MGKSLVIVESPAKAKTINKYLGNQYIVKSSVGHIRDLPTSGSAKTTTDPKARAKQAALTRKMSAEEKEVYKQNKAREQLINRMGIDPDNDWQAHYEILPGKEKVVAELRKLADQADHIFLATDLDREGEAIAWHLQESIGGDPTRYRRVVFNEITKNAIQEAFKSPGMLDINRVNAQQARRFLDRVVGYMVSPLLWEKIARGLSAGRVQSVAVRLVSERESEIRAFIPEEYWEVKAQLDTSKGERAKYEVKRFKDEAFKPVNEAQAMAAKSALEGAAYKVTEREDKPTKSNPSAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVENCRTFIQQEYGDRYLPKAPNVYSSKEGAQEAHEAHEAIRPSDVTTRPNQLSGMERDAERLYNLIWQQFVACQMTSAEFTSSSLKVSAGDYELRARGRVIRFDGFMKVMPPVSRKEEDTLLPDVKVGDMLDLHEILASQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVHVENKRFYANKMGDIVTERLIESFSDLMDYGFTANMEAALDTVAEGDKDWLDLLNEFYADFTVKLEMAQNSAAGMRRNEPVETDIDCGNCGRKMQIRTGSTGVFLGCSGYALPPKERCKNTMNLVSGDEAVNIDEDEDAESRQLRQKRRCKICNTAMDSYLLDEQRKLHICGRNPDCDGYEVEQGVFKIKGYDGPLIECDKCGSDMQLKSGRFGKYFGCTNDECKNTRKLLRNGEAAPPKMDPVDMPELACEKVEDHYVLRDGASGLFLAASQFPKNRETRAPYIKELLPHKDEIDPKYAFLFKAPTQDDNGNDALVRYSRKTKEQYVQTEVDGKATGWKAFYDGGKWQVSGSAKPTKAAPKAKATRKKKS
(1588) DNA topoisomerase 3 [Pseudoalteromonas atlantica T6c]
10
MILYIAEKPSLGRAIAQGFSGQQQKHDGYITLGNGDCVTWCIGHLLEQAEPDKYDPAYAKWALQHLPIVPQDWILVPKKGTSKQLSVIKRLLKTASQVVNAGDPDREGQLLVDEVITYCKVKRDIIDNAGRLLINDLNLNAVKKSLTNIRPNREFTGLSISALARSRADWLYGLNLTRAYTLLGQRGGYSGVLSVGRVQTPVLGLVVRRDAEIAQFKSKPFYEVMATLATQTEQPSQTFTAKWQPSSACEPYQDEEGRVIVKKLAETVVNKTRGQPGVVESYTVKDKQSPPPLPYNLSALQIDASKRFNLSPKAVLTVCQSLYERHQLITYPRSDSRYLPMEHFSEATKVLSAIKANAPEQQSAVENANSKLKSKAWNDSKVDAHHAIIPTSRNKAISSLSGDEAKIYQLIATQYIMQFYGPHKYQEQVAVVTIAGGTFVAKAKATTDKGWLVLTKQNGVAIPENGQTKNEPALPTLVKGQALDCVDSQLVEKQTSPPKHFTEATLLAAMTGIARYVQDANIKKILKDTDGLGTEATRASIIDLLFKRQFMQKSGKEIHATPTGKALIYALPSESTQPDMTAIWEANLDKISQRKMRYQDFMQPLTHTIGELINASQRIDTSQFAGLASTKPAYKKKWRKKKKAS
(634) DNA topoisomerase 1 [Pseudoalteromonas atlantica T6c]
9
MAKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGKVPPKKPAKELKLLSEKKRESYLREHEYRKLVDRMGVDPKNDWEAHYEVLNGKEKVVNELKKLAKNADTIYLATDLDREGEAIAWHLQELIDDPSKDYQRVVFNEITKNAIQEAFSEPGKVNVERVNAQQARRFLDRIVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDVHADLVTAKQSDLRMQVAKYNDKAFKPVNKAQTDAALSDLEGADYKVVSRDSKPTQSRPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSKEAVDACRDYIGDNFGDKYLPENALKYGSKEGAQEAHEAIRPSNVLLKSESLSEMERDAQRLYELIWRQFVACQMTPAKYDASTIRVSANGYELTAKGRVLKFDGWTKVQNPQRKKGEEDFLLPDVKEGESLNLKQLDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLESKRFYAEKMGEIVNDRLLENFDNLLSFDFTAKMEQELDEIANGKVSWKDVLNDFYGDFEQKLHLAEKDPEDGGMRLNQAVPTDIACPKCGRPMNVRTASTGVFLGCSGYNLPPKERCTGTMNLTSGDEVIKVDDEEELETELLRAKRRCPICATAMDSYLVDETRKLHVCGNTPTCPGIEVEEGTFKIKGYDGPIIECDKCGSNMELKNGRFGKYFGCTNEECKNTRKLLRNGEAAPPKEDPVDLPELECTKSDAHFVLRDGASGIFMAAHNFPKSRETRAPLVAELARFRDRISPKFYYLADAPAKDPDGNDTLVRYSRKTKQQYVMSENEEGKATGWSAWYTDNKWTVEDKRKKAK
(681) DNA topoisomerase [Pseudoalteromonas haloplanktis TAC125]
10
MLPKPHKKSDGFITAGNGDVVTWCIGHLLEQAEPEAYNPDYKKWAVEHLPIVPNEWKLVVKSKTRKQFTVVKTLIKKADTLVNMGDPDRVGQILIDEVINHCGVSKAKKTQVLRCLISDLNPAAVKKALNNLRKNTDFIPLATSALARARADWLYGINMTRLCTLQGRQSGYNGVLSIGRVQTPVLGLIVHRDLEIANFVSKPFYEVICTLLTSKGEAYQAKWRPSKACEPYMDEDNRVLSKPLALNVISKVQNKAGKVVNVTQAKKATPPPLPYSLSALQIDAAKRFGMSAQSVLDTCQQLYERHKLITYPRSDCRYLPKEHLNDVKQVVGAIGKSCSALSDAANNANLSLKNKAWNDSKVSAHHAIIPTSKSTDLSRLSPAENNIYELVARQYLIQFYPPFEYVDKQIDTEVSGGLFISKQKDVVSQGWKALFPSKQKSQAESEFSAVSLPNVSKGDEVHCQQADLIEKQTTPPKYFTDATLLSAMTGIARYVTDASIKKVLRDTDGLGTEATRAGIIELLFKRQFLTRKGKDIRATDVGTQLICSLPERMTIPDMTAHWESQLEAISQKEIKYAHFMDPITQSIDTLIAEVKTVTFNGLKGKGTPYKSKKYFKTKTKVNKKNVERL
(1089) DNA topoisomerase 1 [Pseudoalteromonas haloplanktis TAC125]
9
MGKSLVIVESPAKAKTINKYLGNDFIVKSSIGHVRDLPTSGSGKNKVPATKTPAEVRKLPPEEKAAYKKQRDYSNLVARMGIDPDKGWEPHYEILPGKEKVVQELKKLAENADQIYLATDLDREGEAIAWHLQEIIGGEPAKYKRVVFNEITKNAIQQAFETPGELNTDMVYAQQTRRFLDRVVGFMVSPLLWAKVARGLSAGRVQSVAVRLLVEREREIKAFIPEEFWDIHADVKNAESELRLEVAKQADKPFKPVNEAQASAAVKSLENAEYKVISVDEKPSKSRPSAPLITSTMQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKDAVAMCREYVTEQFGEKYLPKDPINYSSKGNAQEAHEAIRPSSVTVLSGHIEGVDADAKKLYELIWRQFVACQMVPAEYDLTTLTVAANDFQLKAKGRVLRFDGWTKVQPAIRKKNEEDQSLPAVTVGETLTLIELDPKQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFFAEKMGEIVTDRLVENFEDLMNFDFTAKMEGRLDDIAEGERIWTEVLDKFYADFSTQLTVAKDEPENGGMRLNEMVETDIECPTCSRKMGIRTASTGVFLGCTGYNLPPKERCTTTMNLVSGDEAVAADSADAEDLETETLMQMKRCPICETAMDSYLIDETRKLHVCGNNPACSGHVVEQGTFKIKGYDGPLIECDKCGADMELKSGRFGKYFGCNNDECKNTRKLLKNGEAAPPKEDPVHITELECEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPKVEELQRFRDRISPKFYYLADAPAQDPDGNLAVVRYSRKNKEQYVMTEVDGKATGWTAHYVAGKWVEEAKKKAAPKKKAAAKKAPAKTKAKAKTKKDDE
(1830) DNA topoisomerase 1 [Brucella suis VBI22]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRITNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRNIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1853) DNA topoisomerase [Colwellia psychrerythraea 34H]
7
MKLYIAEKPSLGRAIAAALPKPQKNHKTHIELANGDVVSWCIGHILAQADPEDYDAELKKWRMESLPIVPQQWQLKPIARTRSQLTVLRKLVKQADEIIHAGDPDREGQLLVDEVIDYFKLSKTKKANIKRLLISDLNLPAVKRALTSLKPNSDFMPLSISALARSRADWLYGINLTRAYTLQGQKTGYNSVLSVGRVQTPLLGLVVRREQEISEFVSKPFFQVQAHIALSSKDAVAFTAKWQPSENCQPYCDEEGRVLVKALAENVVKRIANQPATISNIDSNEKQQAAPLPFNLSQLQISAAKQFSMNAKLVLDVCQALYERHKLITYPRSDCRYLPKEQLKQASGIVNTLANSSLPCNKPAQGANTSFVSKAWNDKKITAHHAIIPTEKSPENINLNTFEKNVYLLIVRQYLVQFYPAYIFQQTKVELLIAGGNFMSQAKTEKQLGWQVLFPKSNKTNNQSKLEHGQEQEQTLPPLTKGQLLHCQQGELIEKHTSPPQSFTDATLLGAMTGISRYVNDAAIKKVLKETDGLGTDATRAGIIDLLFKRGFLQRQGKAITATKVGVALITALPTMATLPDMTAQWEATLTAISEKNANYLSFMQPLTVIVNEMVQGASQQSFSGLPKVAFKPKRGKRTFQKKAVKKAS
(1179) DNA topoisomerase 1 [Colwellia psychrerythraea 34H]
9
MAKSLVIVESPAKAKTINKYLGNDFIVKSSVGHVRDLPHSSTGKKVAAKSPAEVRKMEPAAKAKYKAKRDKQALVNRMGIDPDKNWAADYQILPGKEKVVAELKKLADKADIVYLATDLDREGEAIAWHLKEIIGGEDEKFRRVVFNEITESSIQQAFATPGELSMPGVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEKEREIKAFDPKEFWEIAVDTHASTGEVLTLDVTHENGKAFKPTTEKETNAALAILKPADYAVSKREDRPSKSTPSAPFITSTLQQAASTKLGYGVKRTMGLAQRLYEAGHITYMRTDSTNLSKDAVEMCRKYISDSFGDNYLPENAKTYGSKAGAQEAHEAIRPSNVKLEAAFLEGIEADAKKLYELIWRQFVACQMTAARYTVSTLTISAASFDLKAKGRVMQFDGWTIVHPQLSKGDDTHLPDLQVGEALTLDKIEPSQHFTKPPARFGEASLVKELEKRSIGRPSTYASIISTIQDRGYVRLDKKRFYAEKMGEIVTNSLSGSFEKLMSYEFTSNMEQELDEIAGGSADWKGVLDEFYKNFTKQLSKADQPSEDGGMQTNEPVLTDIDCPTCNRKMGIRTAQTGVFLGCSGYALPPKERCTKTMNLTAGEEAVSILAEDAETEALMAMRRCDKCGTAMDSYLIDETRKLHVCGNNPVCDGIEVEKGEFKIKGYDGPILDCDRCESPMELKSGRFGKYFDCTNEECKNTRKLLASGEAAPPKEDPVQLPELECEKSEAHFVLRDGAAGIFLAAHTFPRSRETRAPKVAELQRFRDRISEKFYYLADAPAEDNEGNLSVVRYSRKTKEQYVMTEIATEEGKPKATGWTAKYIDGKWIEDIPKKKVAKKKAAKKPAAKKKAKTAAE
(84) DNA topoisomerase 3 [Psychromonas ingrahamii 37]
7
MKLYIAEKPSLARAIADALPKPHRKADGCIYVGNGDVVSWCIGHLLTQVDPEAYDPEYKKWKFEHLPIIPENWKLKSTPRTSKQLSILKKLIKQADNLVHVGDPDREGQLLVDEVIHFSGVKGNKLKQVERCLVSDLTTNAVKRSLQQLRSNQEFIALSTSALARTRADWLYGLNLTRVYTLQAQKSGYQGVISVGRVQTPLLGLVARRDKEIEVFVSKPFYEVEAHLTTLKPENVAAFTAKWKPSEACEKYQDHEGRVLVKKLAENVAQRISQQHAVVKSFTAKNKKQVAPLPYNLSALQIDAAKRFSYTALEVLDICQALYEKYKLITYPRSDSRYLPKNHLSQAGSVTRAIANNQPALKKAVSNADISLQSRAWNDKKVDAHHAIIPTDKHQSLTSLDTASQNIYALIARQYLCQFYADYHYGECVAEIEINNGLFISKAKAKISDGWKVLFDKQEKDSYLPALSKGQKLFCDKGEVIEKNTQPPAYFTDATLLAAMSNIARYVKDGELKAVLKETDGLGTEATRAGIIELLFKRLFLQRTGKLIKATETGRKLIESLPEMLTLPDMTAQWEMELNAISQKEQSYQGFVVPLQNQLKSIIEKAIADGPRALANLPSSGNVFKKTYRKKSTKKGTFKKKGS
(1563) DNA topoisomerase 1 [Psychromonas ingrahamii 37]
9
MSKFLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSGSAKKKIEAKGTKSLAGMTPAKKEKEKAKRTQSALVARMGVDPNDHWKANYEILPGKEKVVAELQKLAVDAPIIYLATDLDREGEAIAWHLREVLGGEHQKYKRVVFNEITETAIQEAFEHPTELNIDGVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERERLIKVFNPVEFWDLHADVQDKTKSDLRLEVFKENGKFFKPVTETETLKAVDHLKSAEYKVLSREDKPTTSKPSAPFITSTLQQAASTRLSFGVKKTMMLAQRLYEAGYITYMRTDSTNLSKEAVGSARDFISDEFGKNYLPAEPVVYSSKSGAQEAHEAIRPSDVGQLAALLVGVDRDAQRLYELIWRQFLACQMLPALYDATTLVVQAGDYQLRAKGRTLRFAGWTKVQPVAKTQVDEVQFPELAIGEVLELVELDPKQHFTKPPARFTEAALVKELEKQGIGRPSTYASIISTIQDRGYVKVDKRRFYAVKMGEIVSDRLSENFVELMSYDFTAQMERNLDAIAEGKANWTEQLDDFYQDLTTLLEKAERDPEEGGMRLNEPVIIKEIHCPTCDREMGIRTASTGVFLGCSGYALPPKERCKTTINLVDGEEVVDLLSSEDLETAALMAKQRCPKCDMAMDSYLVDEKRKLHVCGNNPLCDGHLVEYGEFKIKGYDGPVVECDKCGSDMQLKDGRFGKYMGCTNEECKNTRKILRSGEVAPPKEDPVDLPELECEQSDAHFILRDGASGIFLAANTFPRSRETRAPKVAELARFKDRISPKFYYLAEAPQKDPEGNLAVVRYSRKNKEQYVMTEIDKKATGWTAKYIDGKWVEEQTKKRAVKAKK
(1068) DNA topoisomerase 1 [Idiomarina loihiensis L2TR]
9
MAKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTRATETIKSKPAAEVRKMSPDAKAKYQKERDYKRLIARMGVDPENDWEAHYEVLQGKEKVVKELKQLAKKSDEIILATDLDREGEAIAWHLRELIGGDDSRYKRVVFNEITKKAIQEAFQHPAELNTDRVNAQQTRRFLDRVVGFMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWDVHADLNTPADESLRMQVMKQAGKNFRPSNKQETDAALALLKKAGYEITGREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSSEAVDACRELITKDFGKNYLPDDPVRYGAKSNAQEAHEAIRPSDVKVKSESLASVERDAQRLYELIWRQFVACQMVPARYDSTTLTATAGDFELKARGRVMRFAGWTKVMPPASSKKDGDATLPDVKKGDALQLEKLNPEQHFTKPPARYGEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFFAEKMGEIVNDRLIENFTELMNYNFTAEMEQALDDIAAGKRDWKETLDKFYADFKERLEKAELEPTEGGMRENSMVLTDIDCPECGRKMGIRTASTGVFLGCSGYNLPPKERCTKTLNLTPGEEAIEVTDEEERETEALRAKKRCPKCGTAMDSYLIDEKRKLHVCGNNPTCDGQLVEEGTFRIKGYDGPTIECDKCGSEMQLKTGRFGKYFGCTNSECKNTRKLLRSGEAAPPKEDPVPLPELPCEESDAYFVLRDGASGIFLSANTFPKSRETRAVTVKELAKFKDRLPEKFKYLAEAPKEDDDGNDAIVRFSRKNKEQYVVTEIKKKQTGWKAFYRSGKWQVEEK
(1690) DNA topoisomerase 1 [Brucella melitensis NI]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEILRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYPRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1124) DNA topoisomerase 1 [Acidithiobacillus ferrooxidans ATCC 23270]
1
MTKLLIVESPTKAHHIQAMLGSGWSVKATVGHIRDLPIKGDAAYVRPPDFKLNYEITERASKTVPALRAAARDAESVYIATDPDREGEAIAWHVCQVLGIKPGAAKRVTYQEVTEPAIRKAIAAPRTVNMPLVAAQEARRALDRIVGWEVSGPLSNAIGSRASAGRVQTPALSLVVAREQAIRQFKPTPWFQVLAHVAGKDAAPDWRAVWVDGTQEGEYFQDKAHAKALADALPSMALKVTKAETKPVRKPPAPPFTTSSMQMDGARALKAPVDAIMKAAQSLFEHGHITYHRTDSPNLSEEGEGLLRAALKKENLPLVETPRRWRSKGGAQEAHEAIRPTRPMVRQAGENDLEQALYDLIRKRALASQMPDAVYQQTSCTLDGGMFQGRPAVFRAVGSVLKDPGWMALYRETAEDEEGTENPAANPVPRLAVGDAVRAARGECLSKTTKAPPRYTESTLIKALEDHGVGRPSTYASILKNLFAREYIRRKGKSPALYATELGEKIVEALSVFDFSNVDYTREVEADLDRITEGQMRPRDLLAKSFADIQRILDAMPTQARAQGRPCPIEGCDGTVRRLESKRKPGVFFWMCSNRDAHPLLQDNDGEPGAPFAERVEAGDGPACPECGAATSRQETGKGYGYFRCGKGHGSWWDDKGSLGKKWEDRAPAQGAASGPARKNTGSKASSTKRPTKGTRTKARSSIMD
(228) DNA topoisomerase III [Acidithiobacillus ferrooxidans ATCC 23270]
7
MKLYIAEKPSLGKGIAEYLPGSKNKGNGFIQCGVDTVVTWCFGHIFEQEEPDFYTPDDVPTTPKGKKKWRFEELPIFPEQWKKRAKDDAKAQIKVIRALLKKASSVVNAGDPDREGQLLVDEVLEELRWKGPTLRIWLAALDEQSVRKALASLKDNHDYQNLRNSAEARARADWLMGMNLTRAFTLRNSGAGVVSVGRVQTPTLALVVARDEKIEHFKPKDYYVPRINAGFWATWELREDFEGVDAEGYLTDRKAADRLASRAKAEGKATVKDFTSAEKQQQAPLGFSLAELQKVCSAKLGMSAQSVLDAAQALYEEHKAATYPRTDCRYLPEEQHGDAGQILSGLAKAGFADLVKAADSNRKSAIWNTGKVTAHHAIIPTGSMQGSMSPAVAKVYDIIVRSYLAQFYPPYVYRAIKALLTCTSEDWKATANIPVSAGWKAVYGMTDDDNDDTPAQPIPALKKGQVLTVQDADVQAKQTKPPARFTDGSLIEAMSNIHKVVEDEAAKAKLKETSGLGTEATRASIIETLLTRGFLERKGKQILSTQAGRALVHALPKDLTDPVLTARWEDALSSVSEGRVTLQQFEEAQRKFVVRMIEAAKATTVAVGQARPTSGAGRGKSSTGKTRGVGQKTGPACPDCKKLTITLKTKKGDAFFKCEGCQSCWWPDKQDAKKLGTKWGLEKNEYVRREDWISHTQQD
(782) DNA topoisomerase 1 [Acidithiobacillus ferrooxidans ATCC 23270]
1
MAHQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDLQPKEGAVDTEHDFAMRYTPIERNERHVDAIAKALRGADKLWLATDPDREGEAISWHLVELLRERQLLGDKPTQRVVFHEITKKAVQEAIAHPREIAMDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASRLQHAGSAFTGRLTHWQNKKLEQFDIADGDQAQAIRSGMEDDLGRQALRVREVERKSRQRQPAAPFTTSTLQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRTFIDGYYGSEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPESLQGVLERDLWRLYDLVWKRSIACQMAPARLDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDESNRILPPLDVGDEPLVLGIDPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQRRFHPTDLGRVVGRFLINHFERYVDYGFTASMEDELDAVSRGEKQWQPVLSAFWSPFRALLDEKANVSRAEATSEALEEACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAEPVGRDCPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQPKSSGVTCPQCGEGELVEKRSRYGKVFYSCNTYPKCTYAVWGPPVARPCPRCGWPIMIEKSGKRLGEQLACPQSECAFHFPANASDAEIAALLPGYSPPPPREKRAPPAKKAAPARKTTAKTAKKPATEATAVAAQKTAKAKTTSAAAKKPAASKARGPSAGEGKTSPSRKRAAKGASDS
(1438) DNA topoisomerase [Acidithiobacillus ferrivorans SS3]
7
MKLIIAEKPSLAKAIREVVGKEYTVTNAFGHILEQAGPDEYTPAEVPVNPKTSKKRWRLEDLPIFPQTWIKHPKPDAKEQLMKIKGMLKEAALVVNAGDPDREGQLLIDEILEYCGYRGPVQRVWLASLDETSVKKAFANLRDNKEYRTLSQAAEARSQADWVVGMNLTRAWTIKNNGLLSVGRVQTPTLALVVRRDLEIEQFKPRDFFEVIAHCRHQNGEFVVKWRPAVNDGPGFDEEGRLVGRQLADSIAAKAAGHGKIARYDAKDSKQSAPLPFSLSALQKAASAKFGMSANQVLETAQSLYEMKITSYPRSDARYLPEEQYSDAGRILSHLPIPDPLKAKVLANRKHAAWNTGKVTAHHAIIPTGDRAAGLTDAEQKIYDLIWKSYVALFLPDYLYKAISVAVDLGGEQWTTSGRLDMDMGWKALYGASAADDDEDGDGEGKAKLPSMTTGDAIAGQKGEVQAKQTKPPARFTDGTMIEAMSNIHKFVTDATAKAKLKETSGIGTEATRANHLSSIADGKLDPNKFMGAIQQMVREQLGKVTAGVSVSGGKSGGGSGGTKKVGPQCPDCKAATIILKTKTGKPFVKCEKCGSAWWPDRNDPKKLGSKWEARK
(126) DNA topoisomerase 1 [Acidithiobacillus ferrivorans SS3]
3
MSALLIVESPKKAQHIGHILGNGWQVKATLGHIRDLPVTGEAAYVRPPDFAMRYEILDTKHKEIVSGLRAAAQSADAVYIATDPDREGEGIAWHVCQVLKIKPGEAKRVSYQEVTETAIRKALLAPRPVNMRLVAAQEARRALDRMVGWEVSPVLSNSIGAKASAGRVQSPALALVVERERAIKSFKPTAFYQVLAHMPGKDGVSGWRASWIDGTKEGEYFQDKAFAQALADALPSMPLVVSKAESKPVRRAPAPPFTTSSMQMDGARALKVGVEDIMKAAQALFDNGHITYHRTDSPNLSEEGEGLLRAALEKTGLPVVDKPRRWKAKGDAQEAHEAVRPTKPMLEEAGEDANQRALYQLIRKRALASQMPDAIYQQTSCTLNGGTFHWRDLSHPALFRAVGSVLTDPGWRALYTESEDEGEGKETEAANPVPKLSVGDKLKAERGEMVSKKTKAPPRYTESTLIKALEDHGVGRPSTYASIIKVLYKRDYMKRKGKAPALYATDLGEQVVDALRPFDFAGLEYTRLIEESLDLITEGKMPPRDLLAKSYADIQSTIATMPKGADNSQPCPVDGCGGTVSRRESKKKKGSFFWACSNRDNHNLLQDKDGTPGEPFGDKVESNTDGPACPECGKPTGRYETSNRHGFFRCAKGHGTWWDDKGAIGKLWETLPAGKGGKAKPEAAAKKSAGKPARKRTGKPAARRSTIMD
(687) DNA topoisomerase 1 [Acidithiobacillus ferrivorans SS3]
1
MAYQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDLQPKEGAVDTEHDFAMRYAAIERNERHVDAITKALRGAEKLWLATDPDREGEAISWHLVELLRERHLLGNMPTQRVVFHEITKKAVQEAIANPREIAMDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASHLQQAGSDFSARLTHWQDKKLEQFDVTESDQAAAIRSGMEDDLSRQPLRVREVERKSRQRQPAAPFTTSTLQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRDFIGGHYGGEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPEALQGVLERDLWRLYDLIWKRSIACQMAPARMDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDEGNRILPPLNTGDEPQVLDINPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQRRFRPTDLGRVVGRFLTNHFERYVDYGFTASMEDELDAISRGEKQWQPVLSAFWGPFRALLDEKANVSRTEATSEALDEACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAEPVGRDCPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQPKSSGVTCPECGEGELVEKRSRYGKIFYSCNTYPKCNYALWGPPVARACPRCAWPIMIEKSGKRLGEQLACPQSECAFHFPANASDTEIAAMLSDYTPPPPREKRAPPAKKAAPARKAAAKSTRKPAVKAATAANKPAKAETTAAVVKKPSKAKTPAAKKSTSSKNTTSSASEAATPAARKRSVKNVTNS
(981) DNA topoisomerase 1 [Legionella longbeachae NSW150]
1
MSKHLVVVESPAKAKTIQKYLGNDYEVIASYGHVRDLPARKGSVNPDKQFAMTYVPIEKNARHIETIAKILKKSDSLLLATDPDREGEAISWHIYELMKEKNLTKDKTVHRIFFNEITKSAIQDAINHPRTISMDLVNAQQARRALDYLVGFNLSPLLWKKVRRGLSAGRVQSPALRLIVEREEEIESFVAQEYWKILAQCFHANSPFEARLTHYKNEKIQQFTIVNQEQAQQIKEFLIDQAKGSLFVTNIEKKQRKRKPSPPFITSTLQQEAARKLGFTARKTMMVAQQLYEGIDIGTGTVGLISYMRTDSVNLSVEAIEEIRQFITERFGAANCPTSPRAYKTKSKNAQEAHEAIRPTSIKRVPEMVQSSLTTDQYKLYNLIWKRTIACQMADAVLDTVAVDLTCGEGTIFRANGSTVTFPGFLSVYEEGRDDAKDDENDGSLLPVLVVGEKVNVQDILANQHFTEPPPRYSEATLVKALEEYDIGRPSTYATIIHTLQQREYVVVDKKRFFPTDVGRIVNRFLTGYFTRYVDYKFTAELEDTLDAVSRGEKEWIPVLDEFWKPFVQQIKTTDEQVQRKDVTSEVLDEKCPKCEKPLSIRLGKRGRFIGCTGYPECDYTQDIAGQENEKKEPEVIEGRVCPECSSPLHIKVGRYGRFIGCSNYPQCKHMEPIEKPADTGVDCPKCHQAKILQRKSRKGKIFYSCGNYPKCDYALWNEPINQPCPKCNWPILTVKESKKFGRQILCPQEGCGHSTKEE
(1371) DNA topoisomerase 1 [Coxiella burnetii RSA 493]
1
MVKSLVVVESPAKAKTIEKYLGKDFKVMASYGHVRDLIPKEGAVDPEDHFKMHYQAIERNIRHMDAIAKALKPCHNLYLATDPDREGEAIAWHVKQMLESRNGLKDKKFSRVVFHQITKKAVQHAIENPRDISMDLVNAQQARRALDYLVGFNLSPLLWKKIRPGLSAGRVQSPALRLIVEREIEIENFESQEYWTIHADCHAQQQPFDARLIEFQGEKLEQFSIVNEKQAHETRDAITQAANGKLTVAKVVKRERKRNPAPPFITSTMQQEAARKLGFSASKTMQIAQQLYEGVNLGEEGAMGLITYMRTDSVTLASEALQEIRQLIEEKYGQENVPEQTRIYKTKSKNAQEAHEAIRPTSAFRTPENLKKYLNSDQLKLYTLIWKRTIACQMIEATLHTVAVDLKAPNAIFRANGSTIVKPGFISVYQETFDDKKKEEESDSKMLPPLEEGQTVDVNEIKSEQHFTEPPPRYTEASLVKALEEYDIGRPSTYASIIATLKNRKYVDVDNKRFIATDVGRIVNRFLTHYFTKYVDYGFTAKLEDELDDIARGEKTWIPVLETFWSPFKNLVDVTEKTVKRSDVTQEKIDEKCPKCSAQLSIRLGRRGRFIGCTAYPDCDYTRNLTEIAAEAQAVLEGRQCPECQSNLIIKMGRYGKFIGCSGYPNCKYMEPLEKPKDTNVTCPKCKKGTILQRKSRRGKIFYSCARYPDCDYALWNEPVAEACPKCGWPILSIKTTKSRGTEKVCPQKSCNFIEAYDGDKPSLD
(448) DNA topoisomerase 1 [Alteromonas sp. SN2]
9
MAKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGKVEPKKPAKELKTYSEEDKQEYLRRHEYLKLVDRMGVDPEQNWKAHYQVLQGKEKVVNELKRLAKDADTIYLATDLDREGEAIAWHLQELLGSKGKTYQRVVFNEITKNAIQEAFSDPGEVNVARVNAQQARRFLDRVVGFMVSPLLWKKIARGLSAGRVQSVAVRLVVDREREIKAFVPEEFWDIHADLTSEQKAALRMLVAKHEGKAFKPVNKAQADKALEDLNGAKYLVESRESKPTSSRPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQEALDNCRAYIDDNFGSQYLPESPNRYGSKEGAQEAHEAIRPSSVKVNAAHLGDMERDAQRLYELIWRQFVACQMTPAKYDATTIRVGAGNYELTAKGRVLKFDGWTRVQPQLRKKGEEELMLPDVQKGDVLNLNALDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLENKRFYAEKMGEIVNDRLMENFDDLMSFDFTANMEQQLDDIAEGNKDWKDVLNLFYSDFYGKLLNAEKAPEEGGMRLNQAIPAGITCDKCGREMNVRTASTGVFLGCSGYNLPPKERCTNTMNLTPGDEVVKVDDEEELETEALRAKKRCPICSTAMDSYLVDETRKLHVCGNTPTCEGTLVETGTFKIKGYDGPIIECDKCGSDMELKNGRFGKYFGCTNEECKNTRKLLRNGEAAPPKEDPVDLPELPCEKSDAHFVLRDGASGIFMAAHNFPKSRETRAPKVEELARFRDRISEKFYYLADAPQKDPEGNLAIVRYSRKTKQQYVMSENEAGKATGWSAWYNDGKWETQAASKPAAKTKAKAKKK
(51) DNA topoisomerase 1 [Stenotrophomonas maltophilia R551-3]
1
MPKHLLIVESPAKAKTINKYLGKDYTVLASYGHVRDLIPKEGAVDPDNGFAMHYDVIDKNEKHVDAIAKAAKSADDILLATDPDREGEAISWHIAEILKERGLVKDKPMQRVVFTEITPRAIKEAISQPRAIASDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIAAECAHPSQHFNAKLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGALHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVAIGDEGTVGLISYMRTDSVNLSQDALAEIRDVIARDYGIASLPDQPNTYQTKSKNAQEAHEAVRPTSALRTPAQVSRYLTDDERKLYELIWKRAVACQMIPATLNTVSVDLSAGSDHVFRASGTTVVVPGFLAVYEEGKDNKSAEDEDEGRKLPAMKPGDRIPLERIVADQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVEMEGRSFRPSDVGRAVSKFLSSHFTRYVDYDFTAKLEDELDAVSRGEEEWIPLMSRFWEPFKELVEDKKESVDRAEASGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEEKPKFASLRPGQSMHTITLEDALELFLMPRALGEDKGEDVSVGIGRFGPFAKRGSTYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKEFEGSDIQVLNGRFGPYISDGRMNGKIPKDREPASLTLAEVQQLMEETGKPVRKGFGKKAAAKKAPAKKAAVKKEAAPKKAAAKKAPAKKTVKKAAAKKAPAKKAVKKAAK
(941) DNA topoisomerase [Marinobacter aquaeolei VT8]
7
MHLYIAEKPSLARAIAAALPGPHEKGQGWIRCGKGPDAATVSWCIGHLLEPAEPARYNPAWKKWRIEDLPMFPEPWQLTPKDSVRLQFKVLEALVRKADLITHAGDPDREGQLLVDEVLRYLGTKAPVKRILINDLTPKAVARAIQNPRDNREFRPLSHSALARQRADWLYGINLTRFYTLSYQTRGEQGVFSVGRVQTPVLGLVVDRDNTIEHFQPKPWYRVEATFQASEPEADQRPFIARWLPGDEFQDHLDEENRLLDKSVAEQIVAAISGRPGRIDEARFRDRPEPPPLPLSLSALQIEAGRLYRMGAKDVLDTAQNLYERHQLITYPRSDSRYLPEEHFSQREAVIRAIARVAPDLSGFCEKTGTERRSAAWNDQKVDAHHAIIPTVRPAPNGKLSSAEQKIYDLISRFYLMQFAPDAVHREGRLTVAIQDYRFRATETAVIEPGWKTLEIRKREPGQEPEKAPLPRLEKNEPVLCTDPQTNERKTQPPQHFTDATLLSAMTNIARFVADNELRKTLRETDGLGTEATRAAIIDTLFRRDYLFREKRFIRATDKGKSLIAALPESIRTPDRTAVWEATLEGVRRGEEDPRAFLESLKDEIRGFMAQAPAAGLANTETPGTAIHCPKCRAPMVEREGKFGAFFACTRYPACKGTRPLEDHQPEDGTSQKPVPCPHCFSPLVRRKSNKGWFWGCSNFPGCRQTVDDHNGRPAVDLRNST
(135) DNA topoisomerase 1 [Marinobacter aquaeolei VT8]
9
MGKSLVIVESPAKAKTINKYLGSDFIVKSSVGHIRDLPVSGSGSQSDPKERAKQAAATRKMSPDEKAEHKKRKAREQLVARMGVDPDHDWSARYEILPGKEKVVSELKRLAKSADHIYLATDLDREGEAIAWHLQETIGGEPDKYRRVVFNEITKRAIQEAFKDPGNLDNNRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVRLIVEREREIRKFVPEEFWQLHADLAAEGAKDPVRFEVTRYIDKPYRPVNEAQSKEHVERLKAGGFKVAKREDKPTRSRPSAPFITSTLQQAASNRMGFSVKKTMMLAQRLYEAGFITYMRTDSTNLSQDAVVSCREFVQKQFGERYLPEKPRVYGSKEGAQEAHEAIRPTDVARRPTDITGLEKDAEKLYDLIWRQFIACQMADAEFLSTSIVVANGDYELRTRGRIVKFDGFLKAAPQSTKKDEDVALPDIKVDQPLDLKKLDPTQHFTKPAPRYTEASLVKELEKQGIGRPSTYASIISTIQDRGYVKLQNRRFYAEKMGEIVTERLAESFPNLMDYDFTARLEDELDEIAEGEVQWKKVLNDFYAKFRNQLESAEKTDGGMRANTPTETDIPCPSCGRNMQIRVASTGVFLGCSGYSLPPKERCKTTINLVSGDEVVSADDDVEGEGETRLLRKKRRCPKCGTAMDSYLIDEKRKLHVCGNNPDCSGYEVEEGTFRIKGYDGPTLECDKCGSEMQLKTGRFGKYFGCTNSECKNTRKLLKNGEPAPPKMDPVPMPELKCDKVDDTYVLRDGASGLFLAASKFPKNRETRPPLVMEIKPHRKEIDPKYDYLMDAPEKDPEGNPTVIRYSRKSKEQYVMSEKDGKATGWSAWFENGRWVPRDKKK
(1322) DNA topoisomerase [Haemophilus ducreyi 35000HP]
4
MRLFLCEKPSQGNDIAKVLGATKRGDGCLSSGNGQVFVTWGIGHLVEQLNPEQYHPEWKKWSLETLPIIPGQWQLAPKKETKKQYNIVIKLIKQASEVIIATDIDREGETIARELLELAGFKGKIQRLWLSALDDASIRKALALLKPNHETLPLYYAGLGRSRADWLIGMNFSRLFTLLAQQQGYQGKPLSVGRVQSPTLALVVNRDREIQNFVPKNHFTLSALLYSGQQNFTAQYVIPEQYCDEDGLCLSQQTIQAVNQQVQQAGVMKVESVETKREKQSAPLLFALSDLQSEANRLYGLGAQQVLDIAQSLYETHKATTYPRTDCGYLPESQLAEAPQVIKSLISSDSRLQPLTSKLNLTQKSRAWNDKKITAHHGIIPTAVKVDIGKMSEEEFRLYDLIRRRYLAQFLPVSQSDKTQIVLKCGVHTFISRGNVLIATGWKMLCGAPMTKRNGKNGQFWGCTAYPDCQHIENIGKSTARRKGTANSQNISQQIANLRKLVQ
(1513) DNA topoisomerase 3 [Haemophilus ducreyi 35000HP]
10
MMRVFLAEKPSLARAIAEVLPKPHIRGDGYIQCGEHDYVTWCIGHLLEQAEPDAYDERFKTWRMEHLPIIPQQWKLIAKKQTAKQLKVVEKLVKKAEILVNAGDPDREGQLLVDEVFNYLNVPASKKSQIQRCLVSDLNPTAVSKAINKLQNNCDFIPLATSALARARADWLYGINMTRAYTLQGRWVGYQGVLSVGRVQTPVLGLIVRRDLEIEHFTPKDYFEVLAHIIVPTTQERFTAHWQPSKACEDYQDEEGRVLSRALVENVVKRISDQTACVTDYQDKTESEIAPLPYSLSALQIDAARRYGLSAQAVLDICQTLYETHKLITYPRSDNRYLPNEHYNERFNVVAAIAHHLTEYQQKPEVVNLALRGRCWNDKKIEAHHAIIPTARQGNLRLTENEKRIYRLIACQYLMQFCPDAEYSKRKITLDIAGGTFIAQARNLVTAGWKALLGKEDCDEMIEPLLPAVQKAQRLHCEKREIISKKTQLPRHFTDASLLSAMTGIARFVQDKQLKKILRETDGLGTEATRAGIIELLFKRGFVTKKGRNIQSTETGRVLISALPDIATQPDMTAQWEMQLKQISQKQVSYQQFMHQLTTKLPELLHTDRQKLQKLNIITPLKLPAKRTHTKASIMADEK
(444) DNA topoisomerase 1 [Haemophilus ducreyi 35000HP]
9
MGKSLVIVESPAKAKTINKYLGSDYIVKSSVGHIRDLPKSGSEKAEKVKPISTKGLTAEQKAKVKADKARAALVKRMGIDPYHDWKANYQILPDKDKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGKEEHFSRVVFNEITKNAIQKAFEKPEQLNLDRVNAQQTRRFLDRIVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWDILANTLAENGRLPLALTSYKGKKFVAKNQTEADNAVKALQCCEFVVSDIDKKPTSSKANAPFITSTLQQTASTRLSFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALTMVREYVENHFGTDYLPAKPNFYSSKENAQEAHEAIRPSDVRVKMSDLKGMEKDAERLYDLIWRRFVACQMPPARYDSTSLTITAGDYELKAKGRVLRFDGWTKVLPIQGKTAEDQELPAVMLNEKLTLAEIIPSQHFTKPPAHFSEAALVKELEKRGIGRPSTYATIISTIQERGYVRTENRRFYAEKMGEIVTDRLDESFSDLMNYDFTANMEETLDQIAKGNKNWKEALNSFFSDFSEQLSKAELDELEGGMKPNSLVVTDIDCPTCARKMAIRTASTGVFLGCTGYALPPKERCKTTMNLILEAELFNVLDEESEAKALLARKRCPKCGSAMDSYIIDPTRKLHICGNNPNCDGHIVEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMACTACDNTSKILKNGEVAPPREEPTHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELALYRDRLPAKLQYLADAPQQDPEGNQAIIRFSRKEKRQYVTSEKEGKATKWIVDFIDGKWLERHK
(842) DNA topoisomerase 3 [Pasteurella multocida 36950]
10
MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGADDYVTWCIGHLLEQAEPDAYDPKFKQWRLEHLPIIPEKWQLIPRKDVHKQLTIVEKLIHQADILINAGDPDREGQLLVDEVFSYANLSVDKLNQIQRCLISDLNPSAVEKAVNKLQSNRNFIPLATSALARARADWLYGINMTRAYTLRGRQAGYQGVLSVGRVQTPVLGLIVRRDLEIENFKPKDFFEVLAHIQAETPEKITALSAQEKADIPQFKALWLPSKACEDYQDEEGRVLSLGLVENVVKRIAQQPAEVVEYVDKREHESAPLPYSLSALQIDAAKRYGLSAQEVLDICQRLYETHRLITYPRSDCRYLPEEHFAERTKVFQAISRHISDYQPLPDILNPEQKNRCWNDKKVEAHHAIIPTAKNTPVNLNQREWQIYHLIARQYLMQFCPDAEYRKSKITLNIAGGSFIAQARNLQVAGWKQLLGKEDSDEQQEPLLPVVKKGQILFCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTETGRILIQALPDVATQPDMTAHWESQLTSISQKEMSYQQFMSTLTNFLPELMRYVNFAALRQLSQVEKPPSFSKKTSAKSKKRPT
(914) DNA topoisomerase 1 [Pasteurella multocida 36950]
9
MSKSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAIQQAFEKPEQLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEYWEIDVLTQTQAKQALRLAVTQFKGKKFEPKNATQAQSAVDFLQHADYVVSDLETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALKMVRGYIQSHYGESYLPSKPVFYSSKENAQEAHEAIRPSDVNTLAEQLTGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVRAGEYELKAKGRILRFDGWTKVLPTMSKNAEDQVLPDVQLNEKLHLEHVLPEQLFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNQSFTALMNYDFTANMENILDQIANGEKNWKTELNQFFKDFSQQLSQAELDELEGGMKPNSLVPTDINCPTCGRKMAIRTASTGVFLGCSGYALPPKERCKTTMNLIPEAELLNVLDEASETKALMERKRCPKCGTAMDSYLIDPERKIHICGHNPNCDGYVLEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMGCTSCDNTRKILKSGEVAPPKEEPTHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELALYRDRLPEKLRYLADAPQHDPEGNDAIVRFSRKEKRQYVTSEKNGKATKWIVDYLGNQWVERKK
(876) DNA topoisomerase [Pasteurella multocida 36950]
4
MKLFICEKPSQARDLAGVLGATSKGEGLLATADKSIIVTWGFGHLVEQYQPEDYDEAWKRWAFETLPIIPAQWKMTPKKESKKQYSVVIGLIKKATSVVIATDADREGEMIARELLDLAGYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLMAQAKGYSGKPLSVGRVQSPTLTLVVNRDREIANFVPKSHYALAVQLTTTSGETFVAGLAVPEQYLDESGLCLDSRVIQQAEAQIKQTGLAKVVTVETKREKKSPPLLYALSDLQGECNRLFGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQFSDVPNVIRSLVASDSGLQTLLPKLNLRQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLEMDKTVATLQSSGHTLVARGNVIVAQGWRILFGKNVDEETGNDDEKQGLPVLTKNQQCNVTHSEVRTLQTKPPAHYTEGTLLDAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKGFLLKKKKSLVASAEAVALIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDAFMQKQEAFVKQLIGSCMQQGMSLGNIEIRKCSECGKPMRKINHAKGTFWGCTGYPDCQHKEADKKVKSASNKSAKKSSNLNVLDQLNKLRSQL
(49) DNA topoisomerase 3 [Aggregatibacter actinomycetemcomitans D11S-1]
10
MRLFIAEKPSLGRAIADVLPKPHQRGDGFIKCGENDCVTWCVGHLLEQAEPDAYDARFKQWRLEDLPIVPQKWQLIPKKETHKQLKTVEKLVQQADVLVNAGDPDREGQLLVDEVFSYLNLSAEKRNAIQRCLISDLNPSAVEKAIKKLQPNRDFVPLATSALARARADWLYGINMTRAYTIHGRQAGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVLAWVRDPKGEKTPEKPTALFSALWQPSKACEDYQDDDGRVLSRALTENVVKRIADQPAEVTDYTDKREKETAPLPYSLSALQIDAAKRFGMSAQEVLDTCQRLYETYKLITYPRSDCRYLPQEHFADRMAVMNAISSHLSQFQPLPEIIDPEQKNRCWNDKKVEAHHAIIPTAKNRPVGLTSAEQNVYFLIARQYLMQFCPDAEYRKCKITLNIAGGTFVAQARNLQIAGWKQLWGKEDSDDEQQDALLPVVKKGQILHCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTEAGRILINALPDVATQPDMTAHWESQLDGISRKQASYQQFMENLTQLLPELLHYINFSALRELSRHNSGVKKQGIKKKTSRITKS
(825) DNA topoisomerase 1 [Aggregatibacter actinomycetemcomitans D11S-1]
9
MSKSLVIVESPAKAKTINKYLGNNYVVKSSVGHIRDLPTVGSSTGEKAKAISTKGLSAEEKQAIKHKKEQEALVKRMGIDPYHSWKANYQILPGKEKVVAELKSLAKKVDHIYLATDLDREGEAIAWHLREVIGGDDERYSRVVFNEITKNAIKQAFEHPEHLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLIVEREREIKAFVPQEYWEVSVLTNTPKGDEIRLDVVQFKGKKFEPKNAEQAQSAVDFLSKSDYVISDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMVRGYIEKQYGQTYLPAKPNFYSSKENAQEAHEAIRPSDINVGLDDLAGMEKDAVRLYDLIWRQFVACQMPAAQYDSTTLTVTAGDYSLTAKGRILRFDGWTKVLLQQSKSAEDQALPAVSVNDKLNLSEVQPQQYFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFADLMNYDFTANMEDVLDQIASGDKNWKTELNQFFKDFSTQLTKAELDELEGGMRPNNLVETDICCPTCGRNMAIRTASTGVFLGCTGYALPPKARCKTTINLVPEAELLNVLDDASETKALMERKRCPKCGTAMDSYIIDPHRKLHICGNNPNCDGYLVEEGKFKIKGYDGPIVECDKCGGDMHLKLGRFGKYMACTQCDNTRKILKNGEVAPPKEEPIHFPELKCEKSDAYFVLRDGAGGVFMSAHNFPKSRETRAPKVAELALYRERLPEKLSYLADAPQTDPEGSEAIIRFSRKEKRQYVTSEKNGKATKWIVDFVDGKWVERKK
(628) DNA topoisomerase 3 [Mannheimia succiniciproducens MBEL55E]
10
MRLFVAEKPSLARAIADVLPKPHQRGDGFIKCGKNDCVTWCVGHLLEQAEPDAYNPMFKQWRLEHLPIVPKKWRLIPRKEVAKQLKTVENLIHQADQLVNAGDPDREGQLLVDEVFNYANLSTDKRNAIQRCLVSDLNPAAVEKAVKKLQPNTNFIPLATSALARARADWLYGINMTRAYTIRGRQAGYNGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFFEVLAHIQTEDETPQKFTALWQPSKACEDYQDDDGRVLSLGLAENVVKRITGQPAEVTEYTDKREKETAPLPYSLSALQIDAAKRFAMSAQDVLDTCQRLYETHKLITYPRSDCRYLPNEHFAERMPVLNAISTHCKEYQPLPEVLNTEQKNRCWNDKKVEAHHAIIPTAKNRPVNLNSQELNIYTLIARQYLMQFCPDAEYRKSKISLKIAGGNFVAQARNLQIAGWKELLGKEDENEQLEPSLPIVKKGQQLFCEKGEVISKKTQPPKPFTDVTLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSSEAGRILIQALPDMATQPDMTAQWEAQLDGISRKQASYQQFMATLTELLPELVQFVNFSALRKLSAVANNPKPKNFKKKAKIAQSTETKKEV
(87) DNA topoisomerase 1 [Mannheimia succiniciproducens MBEL55E]
9
MSKSLVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTAGASTGEKAKPVSTKGLTAEEKQALKTEKEKNALVKRMGIDPYHGWKANYQILPGKEKVVADLKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDNRFSRVVFNEITKNAIKQAFEKPEHLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPQEYWEVAVVTKTADNQKITLDVAEYKGKRFDPKNETEAQSAVDFLAKSDYIVSALETKPTTSRPRAPFITSTLQQTASTRLNFSVKKTMMLAQRLYEAGYITYMRTDSTNLSRDALNMARSYIERNFGEKYLPEKPNFYSSKENAQEAHEAIRPSDVNISMNDLQGMEKDAVRLYDLIWRQFVACQMPAAQYDSTTLTVKAGDYELKAKGRILRFDGWTKVLPQLGKSAEDQELPALNVHNKLALDEIQPSQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFAHLMSYDFTASMEDMLDQIATGKKDWKTELNQFFKDFSGQLTTAELDELEGGMKPNSLVLTDIQCPTCGRPMAIRTASTGVFLGCSGYALAPKDRCKTTINLIPEAELLNVLDDASETKALMERKRCPKCDTAMDSYIIDPHRKIHICGNNPNCEGYLIEQGTFKIKGYDGPIVECDKCGSDMHLKLGRFGKYMACTACDNTRRILANGEVAPPKEEPIAFPELKCEKADAYFVLRNSAVGVFMSAHNFPRVRESRPAKVAELAQYRERLPEKLQYLADAPQQDPEGNPAIISFSRKEKHQYVTSEKNGKKTKWIVDYIDGNWIERKK
(785) DNA topoisomerase 3 [Oceanimonas sp. GK1]
10
MILYIAEKPSLARAMAEVLPKPQQKGDGFIRLANGDVVSWCIGHLLEQAEPDAYDPAFKQWRREHLPIIPDDWKLVAKPNTKKQLAVLKKLLKEADSIVHAGDPDREGQLLVDEVISYCNVPAAKREAVQRCLISDLNPAAVKKSLATLKPNKDFVPLSVSALARSRADWLYGINMTRLCTLAGRSTGYNGVLSVGRVQTPVLGLVVRRDRDIADFRPKPFYEVLALLQTDSKAQFRAKWQPSEACQPWQDEEGRVLSRALAENVIRRITGQPGRVLAADNKRQRIPPPLPYNLSALQIDAARRFGLSAKQVLDLCQGLYERHKLITYPRSDNRYLPAEHFGQGPAVLAAIAAVCPGLSQAVAAADTGIRGRAWNDARVEAHHAIIPTTRHTDGARLSGTERQIYELIARQYAAQFYPHQELDEKKVELEIAGGRFVARARQQQVAGWKALFTQGKADEEEDDELQAQLPALKTGDTVQCLQGELQEKQTQPPRPFTDATLLSAMTHIARFVTDGELKKILRDTDGLGTEATRAGIIELLFTRGFLERRGRQIHATETGSRLVDSLPASATTPDMTARWEAVLDAISRKQAGYRQFMEELQGQLPMLIDSVKPDAFRGLQGGKPPRKRRGPVRRRARG
(1804) DNA topoisomerase 1 [Oceanimonas sp. GK1]
9
MSKSLVIVESPAKAKTINKYLGRNYVVKSSVGHVRDLPTAGSAGGKKPAARKTDTKQLSPEEKARLKKEKEHKALIARMGVDPEHGWKADYQVLPGKEKVVSELQALAEKADTVYLATDLDREGEAIAWHLKELIGGDDSRFKRVVFNEITKSAIQDAFSQPAELNLNRVNAQQARRFLDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEKEREIKAFVPEEYWDIQAALSNEQQLALSMMVAKYQGKEFRPTNEADAMAAVTALRASSFEVASREDKPTQSKPPAPFITSTLQQAASTRLSFGVKRTMMLAQRLYEAGYITYMRTDSTNLSQEAVASVRDFIEQHHGSAYLPESANVYGAKANAQEAHEAIRPSDVTLSADQLDGMEADAKRLYDLIWRQFVACQMTPAQYDSSTITVRAGDYELKARGRILRFAGWTRVLSPQSRKGEDTELPAVQAGETLSLNELTPKQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVADRLQESFAELMNYDFTAQMESKLDEIAGGKLDWTQVLDAFYAEFSDELEKAEQPAEEGGMRANQMVLTDIDCPACGRKMGIRTATTGVFLGCSGYALPPKERCKQTINLIPGDDFVLANDEEAETDALRAKHRCSKCGTAMDAYLIDDKRKLHVCGQNPDCDGYELEQGQFKLKGYEGPVIDCDRCGAEMQLKSGRFGKYMACTSEACKNTRKILKNGEVAPPKEDPVHLPELPCSQSDAYFVLRDGAAGLFMAASNFPKSRETRAPLVEELVRFKDRLPAKFRYLAEAPTEDPDGNKAVVRFSRKNKEQYVMTEVNKKATGWTAHYVDGKWQQHQKGKK
(186) DNA topoisomerase 1 [Tolumonas auensis DSM 9187]
9
MGKALVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTSGSASTSANKEGVKKATKPSAADKAQKEYSSLVSRMGIDPEHGWKARYEILPGKEKVVAELRALAAQADIIYLATDLDREGEAIAWHLRELIGGDESRFKRVVFNEITKTAIQEAFSHPGLLNIERVNAQQARRFLDRVVGYMVSPLLWKKIARGLSAGRVQSVALRLIVEKERDIKAFVPEEYWDIHADTQTPTRETLRLQVTAQQGKTFDPKNEQQAMAAVQTLKNAAYQVRDREDKPTSSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVVTVREYIEQQFGKKYLPKEPLTYGSKANAQEAHEAIRPSNVEVKADTLKDMEADAVRLYDLIWRQFVACQMTPAQYDTSTLTVTAADFELKAKGRILRFAGWTKALPPMGRKGDDIELPAVNAGDVLQLIKLDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLVESFADLMSYDFTAQMENSLDNIAQGKLDWHKQLDEFYAEFKSDLQKAEGEAGGMRSNQMVLTDIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKQTINLVPGDEYIAADSEDGEVDALLAMHRCKKCGTAMDSYVLDATRKIHICGNNPDCDGYEIETGQFRLKGYEGPVVECDRCGSDMQLKTGRFGKFMACTNAECKNTRKILKNGDVAPPKEDPVFLPELKCSKSDAHFVLRDGAAGLFMAASTFPKSRETRAPLVAELLRFKDRLAPKHQYLAEAPVADPEGNPTIVRFSRKTKEQYVASEVEGKATGWAAYYTNGRWQVSAGKGK
(1681) DNA topoisomerase [Tolumonas auensis DSM 9187]
4
MRLFLCEKPSQGKDIGRLLGARQRGNGCLNGPGVVVTWCIGHLVEAAPPEAYDEQLKRWTIEQLPIIPQHWRVEVKPKTAAQFKVVKDLLSKATELVIATDADREGELIAREIIDLCGYRGPIQRLWLSALNDASIHAALGKLKPSGDTLPMYHSALARSRADWLVGMNLSRLFTLLGRRAGYDGVLSVGRVQTPTLRLVVDRDREIAAFVSVPFWSIEVALSCTGQTFTAQWLPPSASTDDAGRCLQEPVAQQAVQRIRAAGAAQMVSVETERMREGAPLPFDLGTLQEVCSKQFGLDVQETLEIAQSLYETHKATTYPRSDSGYLPESMHAEAPTVLDSLLKTDPSLRPIIDQLDRTQHSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAAYRLIRAHYLAQFLPPHEFDRTTARFSCGDQTLQAVGKHVVVPGWRLVLAEPQPDDAGDDAAPRSQVLPALHQGLACQVAGVDLKALKTLPPRPYTQGELVKAMKSVAKLVSDPRLKQKLKDSVGIGTEATRANIIGGLLNRGYLIKKGRAIRASDAAFTLIDTVPAAIADPGTTAVWEQALDMIETGQLALDTFIDKQAAWVTQLIAQYRGTSLSIKIPEGPACPQCGGATRQRSGKSGPFWSCAKYPDCKGTLPIESGKRAAPRKRRGGPKAS
(163) DNA topoisomerase [Marinobacter adhaerens HP15]
7
MHLYIAEKPSLGRAIAAALPGPHQKGQGWIRCGTGENAATVSWCIGHLLEPAEPARYNPAWKKWRQEDLPMFPDKWEVMPKDSVQQQLKVLESLIRQAKTIIHAGDPDREGQLLVDEVIRYFGASAPVQRILINDLTPAAVARAIQSPRDNREFRRLSHSALARQRADWLYGINLTRFYTLSYQRQGEQGVYSVGRVQTPVLGLVVERDTTIEHFQPKPYYRIEARFRAQEEEADQQTFTARWQPNEQFQDYLDEENRLLNREVAEQIADSVRNRPGTITESRFRDRSEAPPLPFSLSALQIEAGRLFRMGAKDVLDTAQNLYERHQLITYPRSDCRYLPEGHYSQREQVIRAIARVAPDLEEACNGADLGRRTSAWNDKQVDAHHAIIPTSRPTPNGKLSDAEEKIYGLISRYYLMQFAPDAVHREGKLTVRVSEHEFRATETAILVPGWKTLELKLREARKEPEKAPLPRLEKGEPVFCDDSSLSERKTQPPQHFTDATLLSAMTNIARFVTDTELRKTLRETDGLGTEATRAAIIDTLFKRDYLYRDSRHIRATDKAKALISALPESVSKPDRTAVWEANLESIRRGEGDPRKFLDTLKEEIRGFLDRPQGRPTVDSESIGTTSPEAQPHCPKCRAPMLEREGKFGRFFACTRYPDCRGTRPLEEATPQDGTGQKPIPCPHCFSPLVRRKGKKGWFWGCSNFPGCRQTLDDDNGKPSVRLRKST
(1173) DNA topoisomerase 1 [Marinobacter adhaerens HP15]
9
MGKSLVIVESPAKAKTINKYLGSDFIVKSSVGHIRDLPVSGSGSQSDPKERAKQAAITRKMSPEEKAVHKKRKSREQLVARMGVDPDQDWSARYEILPGKEKVVSELKRLAKSADHIYLATDLDREGEAIAWHLQQTIGGEPEKYRRVVFNEITKRAIQEAFKDPGTLDNNRVNAQQARRFLDRVVGYMVSPLLWAKLARGLSAGRVQSVAVRLIVEREREIRKFVPEEFWQLHADLASAKADQPVRFEVTRHEDKPYRPVNEQQSSDHVSRLKAGTFKVAKREDKPTRSRPSAPFITSTLQQAASNRMGFSVKKTMMLAQRLYEAGFITYMRTDSTNLSQDAINSCRAYIEKQFGDKYRPEKPRVYGSKEGAQEAHEAIRPTEVSRRPADISGLEKDAEKLYDLIWRQFIACQMSDAEFLSTSIVVANGDYELRTRGRIIKFDGFLKAAPQAAKKDEDIALPDIKVDEVLDLKKLDPTQHFTKPAPRYTEASLVKELEKQGIGRPSTYASIISTIQDRGYVRLQNRRFYAEKMGEIVTERLSESFPNLMDFDFTARMEDELDEIAEGDVEWKKVLNDFYGRFRQQLEKAESGEDGGMRANTPTETDIPCPSCGRNMQIRVASTGVFLGCSGYSLPPKERCKTTINLVSGDEVVSADDDVEGEGETRLLRKKRRCPKCGTAMDSYLVDETRKLHVCGNNPDCSGYEVEKGTFRIKGYDGPTLECDKCGSEMQLKTGRFGKYFGCTNAECKNTRKLLKNGEPAPPKMDPVPMPELQCQKVDDTYVLRDGASGLFLAASKFPKNRETRPPLVMEIKPHRKEIDPKYDYLMDAPERDPEGNPTVIRYSRKSKEQYVMSEKDGKATGWSAWYVNGKWQPQDKKK
(1049) DNA topoisomerase [Halomonas elongata DSM 2581]
7
MRLIIAEKPSLARAIANALPASPRREEGALVAGDTVVTWCLGHLLEQAPPDAYDPALKTWRLDSLPILPDHWKLMPRPKARGQLAVIRRLLKSADQVVHAGDPDREGQLLVQEVIEHLGWKRDVARLLVSDLNPPAVKRALERLEDNRRYASLYRAAQARARADWLYGINLTRAWTLVGRQAGHDGVLSVGRVQTPVLGLVVRRDAEIRDFEPRPFFVLWVDLVVSRGQLRAWWVPGDTHRLDDQGRLLDRAPAAALADRLPGAEGRLDSLASRDKRQAAPLPYSLSALQVDAARRHGLSAKAVLDVCQRLYERHQLITYPRSDCRYLPEEHFAQAQRTLSGACRNDETLSRWLAGADFSRRSKAWDDKKVGAHHALAPTGKPADLDRLSRQEADVFRLIARNVLAQFYPALQTREVKAEFLIAGERFRARGQEVLEPGWKPLFTTRDEAPPLPPLSEGEACRVEQAGVEDRETRPPEHFTDASLIKAMMNIARYVDDPAIRRTLRDSDGLGTEATRAGIIETLLERGYLVREGKSLKASRLGSALIASLPEAVGRPERTAQWEQRLANIAEQDDAPAPFLEGLIDDLRGLLGHADAGRVRSALSEARGPEPKASKPARGRGRSTKRGSGQRRQGKGTRRAAGGKRQ
(346) DNA topoisomerase 1 [Halomonas elongata DSM 2581]
9
MGKSLVIVESPAKAKTINKYLGNEYIVKSSVGHIRDLPTSGSGKAASDPKERARQAAATRKMSAEEKAEYRKRKAHDQLIRRMGIDPDHGWEAEYVVLPGKEKVVAELKKLADKADNVYLATDLDREGEAIAWHLRETIGGDESRYRRVVFNEITKNAIQEAFEDPGQLNMPRVEAQQARRFLDRVVGFMLSPLLWAKIARGLSAGRVQSVAMRLIVEREREIRAFVPEEFWDVHADLSPRDGNGETVRFELARQDGKTFRPTSETETLERIAALREANLVITSREDKPTRSRPNAPFITSTLQQAASGRLGFSVKKTMTLAQRLYEAGYITYMRTDSTNLSQEAVAGARDYIGEAYGKPYLPETPNRYTSKEGAQEAHEAIRPSDVTRRAGDLAGMERDAERLYELIWRQFVACQMTPAEYLSTTLTVEASGYELRAKGRVLKFDGYTRVMAPMGRKDEDQSLPDLAEGTALTLEALDPQQHFTKPPARYTEASLVKELEKKGIGRPSTYASIISTIQDRGYVRLENRRFYAEKLGDIVTERLKESFPDLMDYSFTARMEDSLDEVAEGQRRWRELLDAFYAEFREELKVAESEEGMRPNQPVPTDIECPTCGREMQIRTASTGVFLGCSGYNLPPKERCKTTMDLLPGDEAVAADAGEEAETDALRAKHRCPKCGTAMDSYLIDEQRKLHICGNSPDCDGHEVEEGRFRIKGYDGPTIECDKCGSEMQLKSGRFGKYFGCTNDTCKNTRKLLRNGEVAPPKMDPIPMPELACQKVEDHYVLRDGASGLFLAASKFPKNRETRPPLVVELQAHADELPEKYRYLLDAPSADPDGRPAQIRFSRKTKEQFVMTDDNGKATGWKATFADGRWQVEDKRK
(704) DNA topoisomerase [Halomonas elongata DSM 2581]
4
MSRLFLCEKPTQARDIAKVLGASEKGNGCLKGRGITVTWGFGHLLEQANPEAYDPALKRWSMESLPILPTQWKLEVKPSAKKQFTVVKKLLSSASEVVIATDADREGEMIAREILEACQFSGGVSRLWLPALDEASIRKALGDIRPGESTRLLYHAALGRSRADWLVGMNLTRAFTMRAKQLGYDLLLSVGRVQTPVLKLVVDRDREIANFVPKPFWEVVAVFQAEGGTFQAKWQPADDDVLDESGRCINQSAAQAVVARCQGLPGQVTTLETTRKREAPPLAMDLGTLQQTCSKRWGYGAQQVLDIAQALYETHKATTYPRTDCRYLPLSQLDDAQQVVTALLTSDGELAPVVQSLDLTRKSRVWNDSKITAHHGIIPTTSPCDTSKMSEAEWNVYDLVRRHYLAQFLPPHEYDHTDVALEVAGERFATTGRQVQVEGWKVLFRNVQQDDAAGDEATAKTSSQALPPLQAHANVPQSSLDLVSKTTTPPKPFAEGTLIGAMKNAARFEPNPKLKARLKESAGIGTEATRAGIIETLLKRKFLTKKGRAIVATATGRQLIDALPEVVTNPGMTALWEQALDSVAAGELSLEDFMAKQQTLVERLIEQAKSATINLPQEPAKSKACPECGAPMKKRKNDYGSFWGCTKYPDCKGMVKIGSGKKRQGKGRKASNG
(1318) DNA topoisomerase 1 [Xanthomonas oryzae pv. oryzae KACC 10331]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNSFAMRYDLIEKNEKHVEAIARAAKGADDIFLATDPDREGEAISWHIAEILKERGLLKDKPMQRVVFTEITPRAIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIDAHCRHPSQAFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALSEIRDVIARDYGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVPGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTAKLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGTDPVSGKEVSARIGRFGPMVQIGSVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKDFEGSDIQVLNGRFGPYISDGKLNGKIPRDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVKDSAPKKPAAKKTATKTAASKTAAKKAPAKKAAAEKGTKRVVKKTVSKAAD
(31) DNA topoisomerase 1 [Xanthomonas campestris pv. campestris str. ATCC 33913]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNGFAMRYDLIEKNEKHVEAIARAAKSADDIYLATDPDREGEAISWHIAEILKERGLLKDKTMQRVVFTEITPRAIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIDAHCRHPSQPFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALAEIRDVIARDFGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVAGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTANLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGADPVSGKEVSARIGRFGPMVQIGTVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKEFDGSDIQVLNGRFGPYISDGKLNGKIPKDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVKDSAKEAKDAAKKTAAVKKVATKTAAKKAPAKKAAKKATKRVVKKAVSKAAG
(1596) DNA topoisomerase 1 [Methylomicrobium alcaliphilum 20Z]
1
MSNNLVIVESPAKAKTIEKYLGKDFHVLASYGHVRDLVPKEGAVDPEHDFAMKYEIIERNQRHVQAITKAIKQAQALYLATDPDREGEAISWHLYELLKDKKLLKDKPVHRVVFHEITKKAVTEAIAHPAELSIDLINAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSREYWTIDAELSAEEQAFKAKLTHFEGEKVEQFTIDNEERALQVKQTLFDAADGKLLVAKVEKKQRKRNPAPPFITSTLQQEAARKLGFTTKRTMMVAQQLYEGIDIGGETVGLITYMRTDSVNLAAEAIAEIRELIAEKYGAKNVPKSPRDYKTKSKNAQEAHEAIRPTSARRIPVELQKFLSPEQFKLYDLIWKRTISSQMVHATINTVAVDLHCGSERNVFRATGSTIADPGFMAVYLEGKDDTAEGDDKENFLPSLEEGRPVPLNDIIAGQHFTEPPPRYSEASLVKALEEFGIGRPSTYASIISTLQNRDYVTLESKRFYPTDVGRIVNKFLTEHFNKYVDYDFTANLEDELDAVSRGEKDWIPLMRSFWEPFNTLIHEKEESVQRKDVTQEAIDEKCPECGSPLSIRLGRNGRFIGCTNYPECSYTRNLNEDASKSSEPEVVEGRVCPKCESPLVIKTGRYGKFIGCSSYPKCKHIEPLEKPVDTGVECPQCKKGNLLKRKSRNGKIFYSCSEYPKCSYAIWNAPVQENCPECNWPILTLKTTKRRGTEKVCPQKECSYATPYEGDPDDVLGPKG
(20) DNA topoisomerase 1 [Pseudovibrio sp. FO-BEG1]
1
MESPAKAKTINKYLGKDYTVLASYGHVRDLPPKDGSVLPDDDFAMSWSVDSKSQKRLSDIASAVKEADRLILATDPDREGEAISWHVLEVLKKKRVLKDKKVERVVFNAITKSSILEAMKNPRELDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCQRENEIETFLSQEYWSILANLNTPENAPVQARLTGFDGQKITRLDIKNEQEATTIKQMLDGANFSVSNVESKPQRRNPYAPFTTSTLQQEASRKLGFAAARTMQVAQKLYEGANIGGETTGLITYMRTDGVQIAPEAITSARGVIASRYGDEYVPEKPRMYSSKAKNAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIWKRTIASQMESAVLERTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESKRLPPMTRGDSLGRKGIEANQHFTEPPPRFTEATLVKKMEELGIGRPSTYAATLQTLRDRGYVELDKKRLIPQDKGRLVTAFLEDFFNRYVEYDFTASLEDQLDKISAGDLEWKAVLRDFWNPFHEICDEVIKRSNTEVLDALNETLKAHVFPDKEDGSDPRKCPKCDTGRLSLKVSRFGAFVGCSNYNKDKKDGKEPNENPPHCDYTRQLTSGGDSDAGAAADGPQVLGIDPETGLEVSLRTGRFGPYVQLGEEAKPKRSSLPRGWSTADLDLEKALQLLSLPREVGTHPEDGKTISAGLGRFGPFVLHDGTYANLDSPDEVFSVGINRAVTLLAEKRAKGGGRGAAAKPLKELGNHPDGGAINVYSGRYGPYVKWEKINATLPKDVAPEAVTLEQAIELVNAKAATKGKKKAPAKKAAAKKTTAKKAAPKGALKEFGDHPDGGAMELRDSGRLGVRIKWGKEFVSLPKGTDPETVTREQAIELINAKKG
(1747) DNA topoisomerase 1 [Candidatus Liberibacter asiaticus str. psy62]
1
MNVIIVESPAKAKTISKYLGSNYKVLSSFGHIRDLPAKKGSVLPEKEFEMIWNIDPSSQKHLQNIIHAVKSSTILILATDPDREGEAISWHVLDVLRQKNLIEKTKIQRVSFNAITKQVVLNAMKSPRDINLDLVNAYLARRALDYLVGFNLSPILWQKLPGARSAGRVQSVALRLICNRENQIESFVSEEYWSLSVLLETPRNDKFTAHLTDFNGQRIEKKSISNKKEADDLISFVKKATYSVEKIENKPIKRNPWPAFTTSTLQQVASSRLGFSASHTMRIAQKLYEGIDVNGEIVGLITYMRTDGVHMSPDALEAVRRSITSHYGDHYLPEKPRIYSSKSKNAQEAHEAIRPNDFDFLPSKMKQFLDSDQFQLYNLIWKRSVASQMASAKFERTTVNIIATYNDQIGHLRTTGSLLCFDGFLKVWENQYDQEKNSEEDILLPYISANEQLIATETNASQHFTEPPPRYSESSLIKKMEEIGIGRPSTYATILETLYKRKYVIAEKRKILPQNTGRIVTAFLENFFSQYVEYDFTADLEEKLDEISTGKLNWKEVLHEFWEEFIEKIDSIKKLRISNVLDILNDTLSSVIFPPKENNEDSRTCPECHTHSLSLKLSSKYGAFVGCTNYPECKYTRQLTSNPQDIPEMKESVLLGNDLETKESVTLRSGRFGLYVQRGDGKDAKRCSLPKTWKSDSVDYDKAMSLLSLPREIGIHPETQKNIIAGTGKYGYYLNHDGAYTKLESIEQVLTIDLEQAISCITEKKKIEKSSRKNSKNQGHVIGTHPEGGSITVHNGRYGPYLHWKKINASLSKEESPDTVDLEKALKILNIKKQKKL
(1624) DNA topoisomerase 1 [Agrobacterium sp. H13-3]
1
MLTDQFQRKNNMNVVVVESPAKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVLPDQDFEMSWEVDSASAKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLKKKRVLGDKPVKRVVFNAITKKAVLDAMANPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVSLRLVCDREAEIERFVSEEYWNISALLKTPRGDEFEAKLVSADGKKLQGRSIKTGDDANRLKALLEGATYIVDTVEAKPVKRNPGPPFTTSTLQQAASSRMGFSASRTMQVAQKLYEGIDIGGETVGLITYMRTDGVQMAPEAIDAARRAIGEQFGDRYVPEKARFYSTKAKNAQEAHEAIRPTDFNRTPDQVKRYLDADQLRLYDLIWKRGIASQMASAEIERTTVEILADKDGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDDEGRLPQINARENLAKQKINASQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLKTLSDREYIIIDKRKLIPHSRGRLVTAFLESFFAKYVEYDFTADLEEKLDRISAGELDWKQVLRDFWKDFFAQIEDTKELRVTNVLDALNEVLAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNFTRQLTSDGSEAEASVSNEPKALGADPMTGEELTLRSGRFGPYIQRGDGKEAKRSSLPKGWKPEEIDHEKALALINLPRDIGKHPETGKMISAGLGRYGPFLLHDGSYANLESIEDVFSIGLNRAVTVIAEKQSKGPGRGRNGTPAALKELGDHPDGGPITVRDGRYGAYVNWGKVNATIPKGQDPTSVTLDESLVLIAERIAKTGTGGKPAKAKKPAAKKADGDTAAKPKATKAKAATKSKTAAKPKAAAKPKKAES
(1515) DNA topoisomerase 1 [Agrobacterium fabrum str. C58]
1
MNVVVVESPAKAKTINKYLGSGYKVLASFGHVRDLPAKDGSVLPDQDFEMSWEVDSASAKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLKKKRVLGDKPVKRVVFNAITKKAVLDAMANPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFVSEEYWNISALLKTPRGDEFEAKLVSADGKRLQSRGIKTGEDANRLKALLEGATYVVDTVEAKPVKRNPGPPFTTSTLQQAASSRMGFGASRTMQVAQKLYEGIDIGGETVGLITYMRTDGVQIAPEAIDAARLAIGEQFGERYVPEKARFYSTKAKNAQEAHEAIRPTDFTRTPDQVKRYLDADQLRLYDLIWKRGIASQMASAEIERTTVEILADKNGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDDEGRLPQINARENLAKQKINASQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLKTLSDREYIVIDKRKLIPHSRGRLVTAFLESFFTKYVEYDFTAALEEKLDRISAGELDWKQVLRDFWKDFFAQIEDTKELRVTNVLDALNEVLAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNYTRQLTSDGAEADAAASNEPKALGADPMTGEELTLRSGRFGPYIQRGDGKEAKRSSLPKGWKPEDIDHEKALALINLPRDIGKHPETGKMISAGLGRYGPFLLHDGSYANLESIEDVFSIGLNRAVTVIAEKQAKGPGRSGTPAALKELGDHPDGGAITVRDGRYGAYVNWGKVNATIPKGQDPASVTLDESLVLIAERIAKTGTGGKPAKAKKTTAKKADGEAAAKPKATKAKAATKSKAAAKPKAAAKTKKAAE
(1503) DNA topoisomerase 1 [Agrobacterium vitis S4]
1
MNVVVVESPAKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVLPDQDFEMLWEVDTASAKRMKDIADAMKGADALFLATDPDREGEAISWHVLDLLKKKKVIGDKPVKRVVFNAITKKAVLDAMAAPRDIDGDLVDAYLARRAMDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRENEIERFVSEEYWNLSALLKTPRGDEFLARLVSADGKRLQARSVGNGDMANRLKDLLDGANYVVESIEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIEAARSAITQQFGPRYMPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDQVRRYLDADQLRLYDLVWKRGIASQMASAEIERTTAEILADKAGEKAGLRAVGSVIRFDGFIAAYTDHREEGEKSDDDDEDGRLPEINAREALAKQKVNATQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATLKTLSDREYVVIDKRKLIPEAKGRLVTAFLESFFTRYVEYDFTADLEEKLDKISAGELNWKDVLREFWQNFFAQIEGTKELRVTNVLDALNEALAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNFTRQLSADGGTEAEAVGNEPKALGEDPTTGEQITLRSGRFGPYVQRGDGKEAKRSSLPKGWSPTDVDFDKALSLLSLPREVGLHPETGKMMTAGLGRYGPFVLHDGTYANLDGIEDVLTIGLNRAVTVLAEKQANPGGRGRAAPAALKEIGDHPDGGAITVRDGRYGPYVNWGKINATIPKGMDPQAVTMEEAIALIVERAAKEGSGKTKAKPAAKSASAKKAPAKKPAAKATKADADDAADAKPKKAAAKPKATKPKAKPAAKTEKA
(994) DNA topoisomerase 1 [Sinorhizobium fredii HH103]
1
MTMNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLKKKKVIGDKPVKRVVFNAITKKAVLDAMADPRDIDISLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNIVALLKTPRGDEFEARLVSADGKRLQPKSIGNGEDANRLKALLDGASYVVESVEAKPVKRNPGPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDVGGETVGLITYMRTDGVQMAPEAIDAARRAIGSQFGPRYLPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDQVRRVLDGDMLKLYDLIWKRGIASQMASAEIERTTAEIAADNGGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDEDGRLPEINARENLAKQKINATQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATISTLVDRDYVEIDKRKLMPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLREFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRTCQVCGTGKLSLKLGKYGAFVGCSNYPDCNYTRQLSSDSNGDAEAAVSNEPQSLGKDPHTGEEITLRSGRFGPYVQRGDGKDAKRASLPKGWTPATIDHEKAIALLSLPRDIGKHPETGKMISTGIGRYGPFVLHDGTYANLESVEDVFSIGLNRAVSALADKQSKGAGGARGRTAAAALKELGEHPDGGAMTVRDGRFGPYVNWGKVNATLPKGKDPQSVTVEEALALIAERAAKGGVSKGKSAKGRSAATKSTAAKAEKPKAAAKAKSKTAAKAKKG
(389) DNA topoisomerase 1 [Sinorhizobium meliloti AK83]
1
MNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLILATDPDREGEAISWHVLDLLRKKKVIGDKPVKRVVFNAITKKAVLDAMAEPRDIDASLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLPPKAIGNGEEANRLKSLLDGASYVVESVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIEAARQAIGSQFGERYLPEKPRFYSTKAKNAQEAHEAIRPTDFDRTPDQVRRFLDGDMLRLYDLVWKRGIASQMASAEIERTTAEIVADNAGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDEDGRLPEINARENLAKQKINASQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATVTTLIDRDYVEIDKRKLVPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLRDFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRICQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSNGDAEAAAANEPQSLGKDPHTGEEITLRNGRFGPYVQRGDGKEAKRASLPKGWTPAAIDHEKALALLSLPRDIGPHPESGKMISTGIGRYGPFVLHNGTYANLESVEDVFSIGLNRAISVLADKQSKGAGGGRASAAALKELGEHPDGGAITVRDGRFGPYVNWGKVNATLPRGKDPQSVTVEEALALIAEREAKGGVTKGKAAKGKPTGGKSAGTKSAKAASAGTAKAEKPKSAAKTKTKAAAKAKKD
(330) DNA topoisomerase 1 [Paracoccus denitrificans PD1222]
1
MPVVVVESPAKAKTINKYLGDDYTVLASFGHVRDLPPKDGSVDPEADFAMKWEVASESKKHVKAIRDALAADPNLILATDPDREGEAISWHLLETLAPALKKGAEVSRVTFNAITKAAVTEAMANPRQIDQPLVDAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVALRVIVDREMEIEAFKAREYWSVHARLATPRGDEYDATMTVFGGKKLERFDIASEEQAKLAVAAITSRDLRVASVAAKPASRNPWPPFMTSTLQQEASRKLGLGARACMSAAQRLYEAGHITYMRTDGIDMAPEAVMAARDAIKARFGAEYLPKSPRMYKNKAKNAQEAHECIRPTDMMLSPDRLPVSDKDQKALYDLIWKRTIASQMESARMERTTVEIGSADGQVGLRANGQVMLFDGFLRVYDQGRDDEEDEDSRRLPSIEEGERAEKRSVTPEQHFTQAPPRYTEATLVKRMEELGIGRPSTYASIVTTIQDRDYVRKEQNRLIPEDKGRLVTIFLLKYFPRYVSYDFTANLEGELDDISSGERAYREVLRRFWRDFTAALEGTSELRITEVLDAIDEALAPHLYPPRADGSDPRECPLCHKGRLHLKTARSGGAFIGCSNYPDCRFTRPISSPDAEVVGDAVLGVDNGDEISLKNGRFGPYVQRGEATAENPKPPRASIPKGWDLASVDLERALALLSLPREIGSHPEDGVPVEAGIGRYGPYVKHGAKYANLPDVDEVFTIGMNRAVEVLASKQVRGRAAVAAPLAELGEHPEGGSVQVMSGRYGPYVKWGKVNATLPRDLEPGAVTLERALELIAEKAAKSGKKPAKKAAAKKPAAKKPAAKKPAAAKAKKAG
(1266) DNA topoisomerase 1 [Rickettsia heilongjiangensis 054]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKAIIHAVENPRKLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTEKLKSQKFHVDKIEKKQQKRQPQPPFITASLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDKAEEENKMLPPLKEQEPLKTKKVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKPA
(1207) DNA topoisomerase 1 [Rickettsia peacockii str. Rustic]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKTGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTQVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAVRKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGTLEWKAALNNFWSGFNHNIESVNEQNITEIISYVQKALDYHLFGENKESKICPSCHTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(623) DNA topoisomerase 1 [Sinorhizobium medicae WSM419]
1
MSWRRYWRAWSPKQLFQRMSMNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKASDGLILATDPDREGEAISWHVLDLLRKKKVLGDKPVKRVVFNAITKKAVLDAMAQPRDIDASLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLPAKAIGNGEEANRLKTLLDGASYVVESVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGIDIGGETVGLITYMRTDGVQMAPEAIDAARQAIGSQFGERYLPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDQVRRFLDGDMLRLYDLVWKRGIASQMASAEIERTTAEIVADNAGKRAGLRATGSVIRFDGFIAAYTDMKEDGEQTDDGDEDGRLPEINARENLAKQKINASQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATVTTLIDRDYVEIDKRKLLPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDRISAGELNWKDVLRDFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRICQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSSGDAEAAASNEPQSLGKDPHTGEEITLRNGRFGPYVQRGDGKEAKRASLPKGWTPATIDHEKALALLSLPRDLGPHPETGKMISAGIGRYGPFVLHNGTYANLESVEDVFSIGLNRATSVLADKQSKGAGGAGGRTGAAAVKELGEHPDGGAITVRDGRYGPYVNWGKVNATLPRGKDPQSVTVEEALAFIAERAAKGGVTKGKTAKGKSAGRKQAGTKTAKAAGTATAEKPKRAAKTKTKSAAKAKKD
(659) DNA topoisomerase 1 [Roseobacter denitrificans OCh 114]
1
MPVVVVESPAKAKTINAYLGDDYTVLASYGHVRDLPPKDGSVNPDADFEMLWEVGYDSRKHVKAIADALKEDNALILATDPDREGEAISWHLQEALTKRKSIKKDTPVSRVVFNAITKAAVTEAMQNPRQVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVTLRLIVEREMEIEAFRAREYWSVKALLATPRGQEFEAKLTVLAGKKLDRFDIENQTQAELAVQAITSRDLSVKSVEAKPANRNPSAPFMTSTLQQEASRKFGMGARQTMSTAQRLYEAGYITYMRTDGIDMAPEAVTAARDAIKTLYGSKYVPEKPRIYKNKAKNAQEAHECVRPTDMMTKAEDLKTTDADQRKLYDLIWKRTLACQMEAARMERTTAEIASEDGQVGLRATGQVMLFDGFLRVYEEGRDDVAVVDDDDKRLPQIDQGDRLDKRTVTPEQHFTQPPPRYTEATLVKRMEELGIGRPSTYASVVTTIQDREYVRKDKNRLIPEDKGRLVTAFLSNYFRKYIGYDFTADLEDQLDTVSAGNADYKEVLGRFWRDFSAAIAETADLRITEVLEKINEVLEPHLFPPNEDGSDPRLCPNCGAGRLSMRTARSGGAFIGCSNYPECRYTRAFGPPGEEDDSGIPPEGKLLGEDGDDKIYAFKGRFGPYVQRGEVTEDNKKPPRQSIPKDWPPEDVDLPQALKLLSLPREIGPHPEDGIMVWANIGRYGPYLKHAPSTSDRGGTNANLESIEEVFTVGMNRAVQLLAEKVASRGRRGGAAKTLRDLGEHPEEGGPVAIMEGKYGPYVKWDKINATLPKDSDPAELTMEAAIALIDEKAASKGKKRRKAAPKKAAAKKTATKKAAPKKTAAKKKAPAKKAKE
(1205) DNA topoisomerase 1 [Ochrobactrum anthropi ATCC 49188]
1
MNVVVVESPAKAKTINKYLGSNYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSSKRLADIVKALKDSDGIILATDPDREGEAISWHVLEVLNQKKALKGKTVKRVAFNAITKKAVLDAIANPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVADRESEIERFIREEYWNIAALLKTPRNDGFTARLTAVDGKKLGKLDIKNGEQATAIRTMLEGASFKALSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIGKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRYLDDDQARLYELIWKRAIASQMQAADIERTTVDIEAVNSSRSAMLRANGSVTKFDGFLAAYMDHREEEDDDEDSAKLPEIRSGEALAREKIDATQHSTEPPPRYSEASLIKKMEELGIGRPSTYAATLATLRDREYITIDKRKLIPEPKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKDVLRDFWRDFSGNVDDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGMLSLKLGKYGAFVGCSNYPECKYTRQLGGDANGESAAADEPKSLGKDPFTGEEITARTGRFGPYVQRGEGKEAKRASLPKGWTVDTLDHEKAVALLSLPRDIGQHPETGKMISAGIGRYGPYVSHDGTFANLENAEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGSITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKSKKTPARKASASTEKKAAAKKPAAKKAPAKAKSTAKPKAKSKAETVEE
(1623) DNA topoisomerase 1 [Rhodopseudomonas palustris CGA009]
1
MNLVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDADFQMIWEVDPKAASRLNDIAKALKGADKLILATDPDREGEAISWHVLEVMKQKRALKDQQVERVVFNAITKQSVTDAMKHPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRETEIEKFVPREYWSLIATMATPRGETFEARLVGADGKKIQRLDIGTGAEAEDFKKAIEAANFRVATVEAKPARRNPYAPFTTSTLQQEASRKLGFAPAHTMRVAQRLYEGVDIGGETVGLITYMRTDGVQIDSSAITQARKVIAEDFGNAYVPDAPRQYTAKAKNAQEAHEAIRPTDLSRRPSDVSRNLDSDQARLYELIWIRTVASQMESAELERTTVDIEAKAGSRVLELRATGQVVKFDGFLAAYQEGRDDDSEDEDSRRLPAMSENEALKREALAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVRLEKKRLHGEDKGRVVVAFLESFFTRYVEYDFTAGLEEDLDRISNNEVSWKQVLSDFWRDFIGAVDEIKDLRVAQVLDVLDEMLGPHIYPAREDGGDPRQCPSCGTGKLNLKAGKFGAFVGCSNYPECRYTRPLASDSAGDADRVLGTDPDSGLEVAVKSGRFGPYIQLGEAKDYAEGEKPKRAGIPKGTSPSDVDLEMALKLLALPREVGKHPETGQPIKAGIGRFGPYVQHEKTYASLEAGDDVHTIGLNRAVTLIAEKVAKGPSKGRFGSDPGKALGDHPSLGAVAVKKGRYGAYVTAGGVNATIPNDKTEDTITLPEAIALLDERAAKGGGKAKKAPAKKAAAKKASADGEAKPVKKAAAKKAKPKAEGAAASKARAPVAAKTAAKKAAKPKDAAKSSAAKNG
(1366) DNA topoisomerase 1 [Oligotropha carboxidovorans OM4]
1
MNLVIVESPAKAKTINKYLGSSYEVLASYGHVRDLPAKNGSVDPDANFQMIWETDPKAASRLNDIAKALKGADKLILATDPDREGEAISWHVLEVMKQKRALKDQKVERVVFNAITKQSVTEAMNNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREIEIEKFVAREYWSLVATLATPRNDTFEARLVGADGKKIQRLDIGTGAEAEDFKKALETAAFTVSLVEAKPARRNPQAPFTTSTLQQEASRKLGFAPSHTMRIAQRLYEGIDIGGETTGLITYMRTDGVSIAPEAIPALRKVIAEEYGSNYVPSAPRQYTSKAKNAQEAHEAIRPTDVSRRPAKLKARLDNDQYRLYELIWMRAIASQMESAELERTTVDITAKAGARTLELRASGQVVKFDGFLAVYQEGRDDDPEDEESRRLPAMSEGEALKRESLAVTQHFTEPPPRYSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLSAEDKGRVVVAFLQKFFARYVEFDFTADLEEQLDKISNNEVAWKNVLSDFWRDFIGAVDEIKDVKVSEVLDVLDAMLGEHIYEPRADGGDPRQCPSCGTGRLNLKAGKFGAFVGCSNYPECRYTRPLAASSGTSDRVLGKDPKTNLDVAVKAGRFGPYIQLGEPNDYAEGEKPKRAGIPKNMSPADVELDLAIKLLSLPRDVGPHPEDGEIITAGIGRFGPFVRHGKTYASLEAGDDVYTIGLNRAVTLIAEKIAKGPSRRFGADPGKEVGDYPARGGKIMLKKGRYGAYVTIDGINATIPDDKEPDQITLEEAIALIEARAAKGGKAKRAPKKAAAKKAAPKKKATAKKKADSEPESGAKPAKKAATRTAPKARTSTAKPAAKTAAKAKPTAKKSAGKARG
(184) DNA topoisomerase 1 [Hyphomicrobium sp. MC1]
1
MNVVIVESAAKAKTINKYLGSGYKVIASYGHVRDLPAKDGSVEPDHDFNMHWEVDTKSQKIMREIAEAVKKADKLILATDPDREGEAISWHILQILNQKKALGKDTEVERVAFNAITKQSILAALKEPRKIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVCDREAEIEAFKTEEYWTIEALLSTAKNEDVRSRLVAIDGTALKKLDIKDEATATAIRKALLGQDFRIASVEKKATKRNPFPPFTTSTLQMDASRKLGFSAKQTMQIAQRLYEGVDIGGETVGLITYMRTDGVQIVPEAVSQIRDVISAEYGKNYTPFAREYKTKAKNAQEAHEAIRPTDPRRKPDQVRKHLEKDQAALYDLIWKRTIASQMAAADIEQTTAEIDVKGSDGKAYGLRANGSVLMFDGFLKVYEEGRDDRVRTIEKGKDDTADEDDDSRRLPPLAVGDRLKDKEISADQHFTQPPPRFSEATLVKRMEELGIGRPSTYASTMAVLVDRDYVRIEKKRLIPEDKGRLVIAFLESFFKRYVEYDFTADLEEKLDLISNDELEYKQVLRDFWRDFMAAVGEIKDLRVGDVLEALNEMLGPHVFPDKGDGSDPRLCPKCGTGRLSLKISGKYGAFIGCGNYPECNYTRQLTQSSDGDAAALDGKILGYNDDGLAVTMKTGRFGPYIQLGEAEGDEKPKRSSIPRGIDAATLDFERAMQLLSLPRDVGEHPDEGGMITAGLGRFGPFIVHEKDGAKTYVNLESLEDVFTVGLNRAVTLIAEKRAGGGKSRFQRNAPKVVKDLGQHPSEGGAVQVLEGRYGPYVTHNKVNATVPKAKNPAELTMDEAVALINERTANGGGKKGKPARGAKAKAAKDDKPAKAPKADKAAAPKAAKKPAATKTAAAKAEKAPAKKAPATSAGAKKLARAKA
(396) DNA topoisomerase 1 [Hyphomicrobium denitrificans ATCC 51888]
1
MNVVIVESAAKAKTINKYLGSGYKVIASYGHVRDLPAKDGSVEPDHDFAMQWEVDSKSQKIMREIADALKNADKLILATDPDREGEAISWHILEILNNKKALKKGTEVERVAFNAITKQSILAALKEPRKIDEPLVEAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIEAFKTDEYWTIEALLTTSRGDDVKTRLVAIEGTALKKLDIKDEASATAIKAALEGRDFRVASIEKKAAKRNPYPPFTTSTLQMDASRKLGFSAKQTMQIAQRLYEGVDIGGETVGLITYMRTDGVQIVPEAVSQIRDVISAEYGKQYTPFAREYKTKAKNAQEAHEAIRPTDPRRKPDQVRKYLEKDQAALYDLIWKRAIASQMAPADMEQTAVEIEAKGSDGKNYGLRANGSVLLFDGFLKVYEEGRDDRFRYIEKGKDDPEGEDEDRRLPALAEGDHLKDKEISADQHFTQPPPRFSEATLVKRMEELGIGRPSTYASTMAVLVDRDYVRIEKKRLVPEDKGRLVIAFLESFFKRYVEYDFTAELEEKLDLISNNELAYKEVLRDFWRQFIASVGEIKDLRVGDVLEALNEMLGPHVFPDKGDGSDPRLCPKCNQGRLSLKISGKYGAFIGCGNYPECNYTRQLSQSANNGEAALDGKVLGYNDDGIAVALRTGRFGPYIQLGEATGDEKPKRSSIPKGIDAATLDFEKAMQLLSLPRDVGVHPTEGGMITASLGRFGPFILHEHDGAKTYVNLGNVEDVFTIGINHAVTLLAEKRAGGGKSRFQRNAPKVLKDLGAHPSEGGPVQVLEGRYGPYVTHNKVNATVPRGKDPSALTMDEAVALIAERIANGGGKKSKASRSSAKPKAAKAAKPAKGEAAPAAKRTAKPAAAKKAAPAKKSAAKPAAKKLAKAKA
(1146) DNA topoisomerase 1 [Rhodomicrobium vannielii ATCC 17100]
1
MNIVIVESAAKAKTINKYLGADYKVIASYGHVRDLPAKDGSVLPDNDFEMTWEVEADSNRIVNEIAKAVKGADRLILATDPDREGEAISWHLLKILEQKRALNGVSVERVAFNAVTKDAILTAMKNPRKIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVVDREAEIEAFRTREYWTVEAALKNGGGDAFTARLVARAGKKLDKFDIPNEALAHAYRDAIKGQSYRVDSVDAKDHKRNPAPPFTTSSLQQEASRKLGLSPRQTMQIAQKLYEGIDIGGETVGLITYMRTDGVQIVGEAIAQARGQIESQFGARYVPSAPRIYKTKAKNAQEAHEAIRPTDFGRQPDKLRGLSAEEARLYKLIWQRAVASQMASADIERTTAEISVPGKDGVPYGVRATGSVVKFDGFMRLYEEGRDDTDDEDSARLPPLKQGEALKDSGVTAAQHFTEPPPRYTEATLIREMERLGIGRPSTYASTMAVLREREYVKLEKKRLVPEDKGRLVTTFLEAFFKRYVEYDFTAYLEDRLDQISDGKLDWKALLREFWQDFIGAVTDIKDLRVTQVLDALNELLGPHIFPAKEDGGDPRLCPLCNQGQLSLKIGKFGAFVGCSNYPECRYTRQLKTGENGNGDGAAPAGDTVLGNDPETGLAVCLKNGRFGPYIQLGEGGDGEKPKRASIPGGMGLADVDFAYALKLLALPREVGPHPETQKTIMAGFGRYGPYVEHDGKYVKIDAEEVFTIGLNRAVTVIAEGGTGGKGRAPKTEPIKVLGEHPEKGGKMEVLAGRFGPYIKWGKVNATIPKGTEPQDVTVDEAVRLIAARIEAGDGKKGRGKPTKSAKAPAKEKKPAKAKTADAGDEAEAPKKAKTAAPKKAAANGKAKSSAKEKSAKADEADKKPKAKASAKKTTSKAAGGTT
(1538) DNA topoisomerase 1 [Pelagibacterium halotolerans B2]
1
MKVVIVESPAKAKTINKYLGKDFEVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDTNSKKRLADITRALKGADELILATDPDREGEAISWHLLDALKAKKAIKADMPVKRVVFNAITKDAVTTAMQHPRDIDAPLVDAYLARRALDYLVGFTLSPILWRKLPGSRSAGRVQSVALRLVTEREEEIERFKPQEYWSVIPTLNQTGKSFATRLYSVDGDKTDKLAIKTGEDAQGLKTAIEKGNFKVASVDRKPTKRNPYAPFTTSTLQQDASSRLSLSPSRTMQIAQRLYEDGLITYMRTDAVQMAPEAIEAARRVIGKEFGSEYVPEKPRFYSTKAKNAQEAHEAIRPTDLGKHPDTLRNLDPDQHKIYQLIWRRALASQMRSAEIERTTADIDVLAAGRAITLRATGSVVTFPGFLGVYGVEKTDEDDEDGKDLPALNVGDTPALENVAIEQHFTQPPARYTEASLIKKMEELGIGRPSTYAATLKTLQDRDYIKLEKRAIMPEDRGRLVTAFLQSFFTKYVEYGFTAGLEEELDEISAGEIDYKEVLRRFWKDFSHQADEIKDLRVSEVLDALNDLLGHHIFPERPDGTDPRLCPTCGTGQLSLKLGKYGAFIGCSNYPECRHTQQLAESATGQASEAAQGDGVLGADPETGAEIYLKTGRFGPYVQLGEDAKDAKRSSIPKGWDAGSMDLEKALKLLSLPREVGLHPEDGKPISAGIGRYGPFVLHEKTYANLPDVEEVFTVGLNRAVDLIAQKRAGGGRGGRGAAVAAIQTFEHDDGPITVRAGRYGPYVNQGKVNATLPKDLAPEAVTLEKALELIAAKGGSKSKAKAKPKPAAKKPAAKKTATKKPAAKKKAEA
(503) DNA topoisomerase 1 [Mesorhizobium ciceri biovar biserrulae WSM1271]
1
MDVVVVESPAKAKTINKYLGKNYKVLASFGHIRDLPAKDGSVRPDEDFAMSWAVDTASGKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLKQKRALKDKPVSRVVFNAITKSSVLEAMANPRQIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFIREEYWQIAALLGTPRNENFEARLTAFDRKKLQKLDISNKAQADDIKSMLEGATFKAVSVEAKPTKRNPGPPFTTSTLQQAASSGLGFSASRTMQVAQRLYEGMEIGGETTGLITYMRTDGVQMAPEAIDAARDAIAKEFGPKYLPEKPRQYTAKAKNAQEAHEAIRPTDFMRTPASVRQYLDSDQMRLYELIWKRAIASQMQPAEIERTTAEIEAVNGSRTAELRAIGSVVRFDGFIAAYTDQKDDDAEDEENRRLPEIRAGEQLARQAINATQHTTEPPPRYSEASLIKKLEELGIGRPSTYTAILKTLEDRDYVTIDKRRLVPQAKGRLLSAFLESFFKRYVEYDFTASLEEKLDEISDGKLAWKDVLRDFWKDFSGAVADIKELRVTDVLDALNEELAPLVFPAREDGSNPRICPKCGTGNLSLKLGKFGAFVGCSNYPECSFTRQLGDAANPNGENGGGEDGTKVIGKDPYTSEEITLRSGRFGPYLQRGDGKEAKRSSLPKGWTAESIDHEKALALLSLPRDVGQHPETAKMISAGLGRYGPFVLHDGTYANLESIEDVFSIGLNRAVSVIAEKQLKGKGGRNGGTAAALKELGDHPDGGGKIVVRDGKYGPYVNFGKVNATLPKGKDPQSVTMEDALALIAEKEAKGGGGKKPFRKAAAAKAPATKKVAAKKPAAKKPAAKKKG
(662) DNA topoisomerase 1 [Mesorhizobium opportunistum WSM2075]
1
MDVVVVESPAKAKTINKYLGKNYKVLASFGHVRDLPAKDGSVRPDEDFAMSWAVDTASGKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLKQKRALKDKPVSRVVFNAITKSSVLEAMANPRQIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFIREEYWQIAAILGTPRNEAFEARLTAFERKKLQKLDISNKAQADDVKAMLEGAAFKALSVEAKPTKRNPGPPFTTSTLQQAASSGLGFSATRTMQVAQRLYEGMEIGGETTGLITYMRTDGVQMAPEAIDAARDAIAKEFGPKYLPEKPRVYTTKAKNAQEAHEAIRPTDFMRTPASVRQYLDSDQMRLYELIWKRAISSQMQPAEIERTTVEIEAVNGSRTAELRAVGSVVRFDGFIAAYTDQKEDDAEDEENRRLPEIRVGEQLARQAINATQHTTEPPPRYSEATLIKKLEELGIGRPSTYTAILKTLEDRDYVTIDKRRLVPQAKGRLLSAFLESFFERYVEYDFTASLEEKLDEISDGKLAWKDVLRDFWKDFSGAVADIKELRVTDVLDALNEELAPLVFPAREDGSNPRICPKCGTGNLSLKLGKFGAFVGCSNYPECSFTRQLGDAANPNGENGGGEDGTKVLGKDPYTAEEITLRSGRFGPYIQRGDGKEAKRSSLPKGWTPESIDHEKALALLSLPRDVGKHPESGKMISAGLGRYGPFVLHDGTYANVDSIEDVFSIGLNRAVTVIAEKQSKAKGGRNGGTAAALKELGDHPDGGGKIVVRDGKYGPYVNFGKVNATLPKGKDPQSVTIEDALALIAEREAKGGGGKKPFRKAASPATKKAATKKPAAKKKG
(47) DNA topoisomerase 1 [Chelativorans sp. BNC1]
1
MDVVVVESPAKAKTINKYLGKDYKVLASFGHVRDLPAKDGSVRPEEDFAMSWEVDSPSAKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLRQKRALKDKPVRRVVFNAITKKAILDAMASPREVDASLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDLEAEIERFVREDYWQIAALLDTPRGDSFEARLTTLDGKRLQKLDIKSQEEADSIKALLDGAAYRVLSVEAKPTRRNPGPPFTTSTLQQAASSRLSFSASRTMQVAQRLYEGVEIGGETTGLITYMRTDGVQMAPEAIEAARSAVSNTFGPRYLPEKPRHYSSKAKNAQEAHEAIRPTDFSRTPDEVRKYLDSDQARLYEMIWKRAIASQMEAAEIERTTVEIEASGAGRAAGLRAVGSVVRFDGFLAAYAEVKDEDSQDEEDRRLPEINSGEALKRNSVNVTKHTTEPPPRYSEASLIKKLEELGIGRPSTYAAILKTLDDRGYVSNERRKLVPQAKGRIVTAFLENFFRRYVEYDFTADLEEKLDEISDGKLSWKQVLRDFWKDFSAAVGDIKELRVTDVLDALNEELAPLVFPTREDGGDPRICPKCGAGKLSLKLGRYGAFVGCSNYPECDYTRQLGENPAENGEAEAGLNGNKVLGTDPFTGEEITLRSGRFGPYVQRGEGKDAKRAGLPKGWTPEDLDHEKAIALLSLPRDVGKHPETGKMISAGIGRYGPFLLHDGTYANLETVEDVFSVGLNRAVSLLAEKQAKTNGARAKPAALKELGEHPDGGVITVRDGRFGPYVNVGKVNATLPKGKDPMSLTREEALELLAAKAGKTGKKPAKSKARS
(1004) DNA topoisomerase 1 [Azorhizobium caulinodans ORS 571]
1
MQVVIVESPAKAKTINKYLGPGYEVIASYGHIRDLPSKDGSVDPEADFRMLWEVDPKAQKRLNDIAKAVKVADGLILATDPDREGEAISWHVLEVLREKKALKGQKVERVVFNAITKQAVLEAMKAPRAVDVALVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIELFVAKEYWSIAATLATPRGDTFEARLSGADGKKITRLSVGTAEEAAAFRAALDTAAFSVRNVEAKPVRRHPQPPFTTSTLQQEASRKLGLAPARTMQIAQRLYEGVDIGGETAGLITYMRTDGVDMAPEAVTATRNAISAQYGARYLPGTPRKYTTKAKNAQEAHEAIRPTDPSRHPREMARHLDAEQARLYELIWTRTIASQMESAELERTTADIIAKAAGRELELTATGTVVKFDGFLTLYREGKDDEDDDEESRRLPAMSAGEALDKREIKTDQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLAVLRDREYVKLEKKRLVPEDKGRLVTAFLQSFFKKYVEYDFTADLEEKLDEISAAEIDWKQVLRDFWNDFSLAVDATKELRVSQVIDALDEILTAHLFPAKEDGSDPRLCPTCGSGRLSLKMGKFGAFIGCSNYPECRYTRPLSGGEGEAGGDGVRKLGTDPETGLEVTLRDGRFGAYLQLGEAVDGEKPKRSSLPKGLAPADVDLETALALLALPRRVGTHPEDGEPILAGIGRFGPYIQHGKVYANLEAADDVLTVGLNRAVVLLAEKQSRGRGGRGAAPAGRTLGDHPTEGGAITVRAGRFGPYVNHGKINATLPKSQDPDSLTLEQALALIEAKAAASPSARKPARKSASADGAAKKAPAKKTATKTAAKKTTTKAAGTKKTAKAKADAAAEE
(183) DNA topoisomerase 1 [Starkeya novella DSM 506]
1
MQVVIVESPAKAKTINKYLGPGYEVIASYGHVRDLPAKDGSVDPEHDFHMLWDIDPKAQKRLSDIARAVKGADGLILATDPDREGEAISWHVLEILKEKRALKDQPISRVVFNAITKQAVLDAMAHPRTIDAALVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIETFVKREYWSIAATLATPRNETFEARLVGADGKKITRLDVGTEAEATDFRKALESADFKVRSVEAKPARRHPYPPFTTSTLQQEASRKLGLAPAVTMRIAQRLYEGVDVGGETVGLITYMRTDGVDMAPEAVAQARSVIGRDYGDRYVPNAPRKYTAKAKNAQEAHEAVRPTDLSRRPKDVSRHLEPEQAKLYELIWLRTVASQMESAELERTTVDIDAKAAGRALELRATGQVVKFDGFLTLYREGIDDGDEDEENRRLPAMSTGEALANKGIKADQHFTEPPPRYSEASLVKRMEELGIGRPSTYASVLAVLRDREYVKLDKRRLVPEDKGRLVTAFLESFFDRYVEYDFTADLEEKLDLISNGELAWKDVLRDFWRDFTAAVGETKELRVSDVISALDEMLTAHIFPPKEDGSDPRICPTCGTGRLSLKVGKFGAFIGCSNYPECKYTRPLAVQNGDSDNPAEANGTRVLGTDPVSGLEVTVRDGRFGAYLQLGEAKDGEKPKRSSLPKGLAPADVDLETGLALLSLPREIGVHPDNGEPILAGIGRFGPYVQHGRTYANLEAGDDVLSIGLNRAVALIADKQNKGPGRGRGAVGGRELGEHPTLGGQVTVRPGRFGAYVNHGKVNATLPKSMPAESVTLEQAVELITAKAGSAPAKPARRAAAKTASGDKPAKKAAPKKAAAKKSPAKKSG
(1057) DNA topoisomerase 1 [Candidatus Liberibacter solanacearum CLso-ZC1]
1
MNVIIVESPAKAKTISKYLGPDYKVLSSFGHVRDLPAKKGSVLPEKNFEMLWETDKSSQKHLENIISAVKSSTLLILATDPDREGEAISWHVLDILRQRNLIGERKIKRVSFNAITKKVVLNAMENTRDLNLDLVNAYLARRALDYLVGFNLSPILWRKLPGARSAGRVQSVALRLICHRENQIECFVSEEYWLLSVLLETPRGDKFIARLVDFNGQRIEKTSIGNKKEADKLISFLEKATYIVKNTETKPIKRNPWPAFTTSTLQQAASSRLGFSPSYTMRIAQKLYEGIDVNGEVVGLITYMRTDSVHLSLDALEEVRRSISSNFGNSYLPDKPRIYSVKAKNAQEAHEAIRPNDFNFLPSEMKKFLDSDQFQLYNLIWKRSVASQMASAEFERTTISIDATYEDQIAHLRTVGSCLRFDGFLKVWENQNDQENNSDEDKLLPCINKNEKLLAKETNASQHFTEAPLRYSESSLIKKMEELGIGRPSTYAAILETLSKRRYIVIEKRKLFPQNTGRIVTAFLENFFSRYVEYDFTADLEEKLDKISSGKLDWKEVLHEFWKEFIEKIDSTKELRTSNVLDILNDTLSSVIFPAKDNNEDSRTCPSCQKNPLSIKLSSKYGAFVGCTNYPECKYTRQLTTSNQQYIEENLEPLLLGDDPETKEPITLRSGRFGFYVQRGDGKDAKRCGLPKNWDRESIDYDKALSLISLPREIGIHPETQKSIIASMGKYGCYLKHDGHHTKLESIEQVLTINLDQAISCMIQKNKKEKSSRTSTKNQGHVIGIHPEGGSITIHRGRYGPYLNWGKINASIPNNENPDTIDLENALKIFETKIKGKKKS
(1309) DNA topoisomerase 1 [Bartonella clarridgeiae 73]
1
MNIVIVESPAKAKTINKYLGSQYKVIASFGHVRDLSAKDGSVLPDKDFAMKWDIDTASAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDILKQKKVLNNKPIKRVVFNAITKKSVLAAMKNPRDIDISLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICNRESEIEQFIKEDYWSITTYLKTLQDNIFYARLTEFNHKKLGKLDIRSQEQADQIFFMLEKANYRTLSIEAKPIKKNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVEINGETAGLITYMRTDGVQMASEAIDAARKAIIDSFGNHYVPEKPRFYSTKAKNAQEAHEAIRPTDFKRHPNQICNVLDSDQAKLYELIWKRAIASQMRSAEIERTTVEIEAFQEENHANLRAIGSVIHFDGFISAYTDPKEEENSEEDESTRLPQINIGESLKKEKVELTQHTTEPPPRYSESALIKKLEELGIGRPSTYASTLSTLCDRGYIITDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTANLEEKLDLISDGKLSWKDVLHDFWDEFNASITSIQELRIMNVLDVLNVTLAPLAFPTREDGSDCRSCPLCINGQLSLKLGRYGAFVGCSNYPECKYTCQLGTDTKEKSKVVHNDEPIMLGIDPETGKDISLRNGRFGPYIQLGEDKKSKRASLPKGWQIENINFDKALALLSLPREVGTHPETGKIITAAIGRYGPYLAHDGKYANLFSIDEVFDIGINRAITILAEKKNNETNRRRILPTVLTTLGDHPEGGTITIRDGRYGPYVNWNKINATLPRDKDPTTVTLSEALELISAKASTKKTGQKATSKKKLTPKKASPRKEKA
(494) DNA topoisomerase 1 [Bartonella bacilliformis KC583]
1
MDIVIVESPAKAKTINKYLGSQYKVIASFGHVRDLSAKDGSVLPDKDFSMKWDVDTASAKRLNEIAKAVKEANSLILATDPDREGEAISWHILDVLNQKKILNDKPVKRVVFNAITKQSVLDAMNNPRDIDVSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEREHFVKEDYWSITTYLKTPRNDVFQARLIEFNQKKLSKLDIQSQEQANQIRLMLEEAEYCTLSVEAKPTKRNPSPPFTTSTLQQASSSKLGFSASRTMQIAQKLYEGVEMNGETAGLITYMRTDGVQIAPEAIDSARRAISNSFGNNYLPEKPRFYSTKAKNAQEAHEAIRPTDFKRHPDQVRNFLDNDQAKLYELIWKRAIASQMRSAEIERTTVEIKAVQEENYANLRATGSVTRFDGFIAVYTDQRDETNGDEDDLARLPPINVNEILTKEKIETAQHTTDPPPRYSEASLIKKLEELGIGRPSTYASTLATLCDRGYIIIDKRQLTPDAKGRIVTAFLENFFNRYVEYGFTANLEEKLDLISDGKLFWKDVLRDFWDEFNASVTNIQELRITNVLDVLNTTLAPLAFPTREDSSDPRSCSLCKHGQLSLKLGRYGAFVGCSNYPECKYTKQLGTDAGEEREAAHNDEPVILGVDPETGKDIFLRNGRFGPYIQLGEGKEAKRSGLPKGWKTENVNLDKALSLLSLPREVGIHPETGQMITATIGRYGPYLTHDRKYAALSNVDDVFDIGINRAVTVLAEQKENKANRGKTVSSVLAALGDHPDGGSITVRDGRYGSYVNWGKINATLPKDKDPANITLSEALELLSAKTSAPSKTRKVAAKKTAPKKNTTVKKASSTIKKAK
(38) DNA topoisomerase 1 [Bartonella tribocorum CIP 105476]
1
MNIVIVESPAKAKTINKYLGPQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDIDSAAAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDVLRQKKVLKDKPIKRVVFNAITKKSVLDAMNNPRDIDTSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTQLKTIRNDHFQARLTMFNQRKIGKLDIQSQEQADQIRLMLEKAQYHTLSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEVAGLITYMRTDGVQIAPEAIDAARKVIHESFGKDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRSPNQVRNFLDDDQAKLYELIWKRAIASQMCSAEIERTTVEIEAQQGDNRANLRATGSVVRFDGFISVYTDQRDEENNEENETTRLPQINTGEALTKEKVESLQHTTEPPSRYSEASLIKKLEELGIGRPSTYASTLATLCDRGYIVIDKRKLIPDAKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRDFWDGFNTSISNIQELRIANVLDVLNVTLAPLAFPEREDGSDVRSCPLCKNGQLSLKLGRYGAFVGCSNYPECRYTRQLGTTDTEEENEAVRNDEPVMLGIDPETGKDISLRNGRFGPYIQRGESKEVKRAGLPKEWQAENITLERALALLSLPREIGIHPETGKMITATIGRYGPYLSHNGKSARLLHADEVFDIGINRAVTVLAEQQENKTKQSRTTSAALATLGEHPEGGTVTVRNGRYGPYVNWGKINATLPKEKDPISVTLSEALELISAKASSKKAISKRASSKTKAKTKET
(155) DNA topoisomerase 1 [Bartonella quintana str. Toulouse]
1
MNIVIVESPAKAKTINKYLGSQYKVLASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAASKRLNEIAKAVKEADSLILATDPDREGEAISWHILDILRQKKVLKDKPVKRVVFNAITKKSVLDAMNNPRDIDTSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTDLKTIRNEGFQARLTMFNHKKIGKLDIQSQEQADQMRHMLESAKYHTLSVEAKHTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGVEINGEMAGLITYMRTDGVQIAPEAIDSARKVIHEFFGSDYVPEKPRFYSTKAKNTQEAHEAIRPTDFQRIPNQVRNFLDTDQVKLYELIWKRAIASQMRSAEIERTTVEIEAQQGENHANLRATGSVIRFDGFISVYTDQRDEENSEENEITHLPQINTGETLTKEKVEAIQHSTEPPPRYSEASLIKKLEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRNFWDGFNASITNIQELRITNVLDVLNITLAPLIFPGREDGNNVRSCPLCSSGQLSLKLGRYGAFVGCSNYPECKYTRQLGTDPGEEKEVMRNDEPVMLGIDPKTGKDVSLRNGRFGPYIQVGEQKEAKRVRLPKEWQTEKMTLDKALALISLPREIGIHPETGKIITATIGRYGPYLAHDGKYAPLLHADEIFDIGINRAVTVLAEKQENKTKRNRTKTAALATLGDHPDGGTVTIRNGRYGPYVNWGKINATLPKDKDPISVKLSEALELISDKASSKKTTAKKASSKRKET
(1356) DNA topoisomerase 1 [Wolbachia endosymbiont of Drosophila melanogaster]
1
MALLIVESPAKAKTIGKYLSKEFKVAASFGHVRDLPAKNGSVDPDNDFTIKYETIEKAEKYIKELVKAASKTSDIYLATDPDREGEAMAWHVIETLKEKKAISNENNIYRVVFNEITKRAVQEAIKNPREINMDLVRAQQARRALDYLVGFSLSPLLWTKLSGSKSAGRVQSVALKIICEREDEISKFITQEYWSIKAEMQNSKDEAFFAMLSHYDNKKLEKFDIKNEEEAKNLVREIESRQYAVSTVERKQVKRNPLPPFITSSLQQDAVNKLYFNVKSVMRIAQNLYEGIDIGGETVGLITYMRTDGFHIADEAINSIRGSIKSLYGDKYLPQSPRKYVKKVKNAQEAHEAIRPTDINRTPGSIKDYLTPEQFKLYDLIWKRTIASQMESAILDQVVVEISSTDQKVILRASGSSIFFDGFYRVYQDNIEAENEGLLPAMKEGEACKLISVEPKQHFTQPPPRYSEASIVKKMEEIGIGRPSTYATIISVLQDREYVSLDSKRFIPSSRGKIVTIFLETFFQRCVEYDFTAQMEEKLDLISNGHADWKKELGHFWVPFFGHVNSVKQMTHDEVFSGIHDLVIDWFCSEEGRKEVNTKCPACLGGILKLNFGKAGVFLGCSNYPECNHTKEITGSNDNSEYPKSLGIDDITNQEVMIKKGPFGLYLEFNNELKKKKTVSIPKDINVNEIDLSTATQLLSLPKVIGEHPETGKEVKIGLGRFGYYIFYDGRYFSLKKSSKEVLNTELSEAVQIIANSPRKELKSLGVNEKGKEVFICNGRYGFYIKCGKTNVALGKSADIESIDLEKALELIKGKK
(970) DNA topoisomerase 3 [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
10
MRLFIAEKPSLGRAIADVLPKPHKKGDGFIETAQGDVVTWCIGHLLEQAEPDAYDAAYKQWRMESLPIVPSQWQLVAKPKTKTQLTVIKRLLKQADCVVNAGDPDREGQLLVDEVIDFLGYGKTRPVLRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYTLLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFFEVLAHLQTEGNERFSAKWLPSEACLPWQDEEGRVLNRALAAKVVERIQGQPALVEEVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDVCQGLYERHKLITYPRSDSRHLPSDHFNRAGQVREAIASTAPALAKAVSEADGKIRSKAWNDGKVDAHHAIIPTEKQGNPATLGADEAKLYGLIARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGALLEKMTQAPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIIDLLFKRRFLVRQGKSIKGTPTGRALILALPATATTPDMTALWEQHLGRIAERQTSYQQFMGPLTEQLNGLIDGARQDSGASFSALPKAVPGADKRRFTKRKRSTAAGGTSGTAKRGSKRPAKAA
(470) DNA topoisomerase 1 [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
9
MGKSLVIVESPAKAKTINKYLGKDYVVKSSVGHVRDLPTSGSASNEPKKPVIRGIKLSEAEKAAKDRNALFSRMGINPTAGWQANYQILPGKEKVVSELQSLAEKADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKTAIQEAFAQPSELNIHRVNAQQARRFLDRVVGYMVSPLLWKKLARGLSAGRVQSVAVRLIVDKEREIKAFVPVEFWDLNADLLTADKSDLRMEVVSRNGVDFKPVTQAETFAAVAALEGVDYKVVNREDKPTGSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVEAVREYIGEQYGAAYLPSDPNLYGAKANAQEAHEAIRPSSVLVTAEMLEGMEPDAMRLYDLIWRQFVACQMTPAQYDSSTLTVKAGEFELKARGRTLRFAGWTKALPPMGRKGEDSQLPAVTVGEILKLVKLDPRQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIVDRGYVRVESRRFFAEKMGEIVTDRLVENFVELMNYEFTAKMEDKLDGIAEGSLEWKKVLDAFYAEFTQELEKADKAPEEGGMRANQMVLTDIDCPDCGRKMGIRTATTGVFLGCSGYALPPKERCKKTINLVSADEFVSATDGEEAETEALRAKHRCTICGTAMDAYIIDDSRKLHVCGRNPDCDGYEIEKGQFKLKGYEGPSIECDRCGSEMQLKNGRFGKYMGCTNDTCKNTRKILKNGDIAPPKEDPVPLPELKCTQSDAHFVLRDGAAGLFLAASNFPKSRETRAPLVEELKRFKERLSPKHQYLADAPASDPDGNAAIVRFSRKTKEQYVMTEVNGKATGWTAHYDNGKWQESLAKSKKA
(1729) DNA topoisomerase 1 [Aeromonas veronii B565]
9
MGKSLVIVESPAKAKTINKYLGKDYVVKSSVGHVRDLPTSGSASTEPKKPVIRGIKLSESEKAAKDRKALFARMGINPTAGWQANYQILPGKEKVVSELQSLAEKADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKSAIKEAFAQPSELNIDRVNAQQARRFLDRVVGYMVSPLLWKKLARGLSAGRVQSVAVRLIVDKEREIKAFVPVEFWDLNADLLTGDKSDLRMEVVSRNGADFKPVTQAETFAAVAALEGVDYKVVNREDKPTGSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVEAVREYIGEQYGAAYLPAEPNLYGAKANAQEAHEAIRPSNVQVTAEMLEGMEPDAMRLYDLIWRQFVACQMTPAQYDSSTLTVKAGEFELKARGRTLRFAGWTKALPPMGRKGEDSQLPAVTVGEVLKLIKLDPRQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIVDRGYVRVESRRFFAEKMGEIVTDRLVENFVELMNYEFTAKMEDKLDGIADGSLEWKKVLDAFYAEFTQELEKADKAPEEGGMRANQMVMTDIDCPDCGRKMGIRTATTGVFLGCSGYALPPKERCKKTINLVSADEFVSATDGEEAETEALRAKHRCGVCGTAMDAYIIDDSRKLHVCGRNPDCDGYEIEKGQFKLKGYEGPSIECDRCGAEMQLKNGRFGKYMGCTNETCKNTRKILKNGDIAPPKEDPVPLPELKCTQSDAHFVLRDGAAGLFLAASNFPKSRETRAPLVEELKRFKDRISAKHKYLAGAPLTDPDGNPAIVRFSRKTKEQYVMSEVNGKATGWTAHYDNGTWQESLPKAKKA
(1880) DNA topoisomerase 3 [Aeromonas veronii B565]
10
MRLFIAEKPTLGRAIADALPKPHKKGDGFIETAQGDVVTWCIGHLLEQAEPDAYDAAFKQWRMEHLPIIPAQWQLVAKPKTKTQLTVIKRLIKQADCVVNAGDPDREGQLLVDEVIDFLGYPKTKPVQRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYTLLGRKAGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFYEVLAHLLTEGNERFTAKWLPSEACLPWQDEEGRVLNRALADKVVSRINGQPAQVESVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDICQSLYERHKLITYPRSDSRYLPTDHFKRAEQVRGAIAATAPALAKAVSEADGKIRSKAWNDSKVDAHHAIIPTEKQGNPATLGADEAKLYGLIARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGELQEKMTQPPKSFTDATLLAAMTGIARYVQDPEIRKTLRDTDGLGTEATRAGIIDLLFKRRFLVRQGKSIKATPTGRALVQALPATATTPDMTALWEQSLGQIAERHGSYQQFMGPLTEQLNGLIEGARQDSGASFSALPKEAPGAGKRRFTKRKSPAASTTGGPRPRKTASKRQTRAA
(710) DNA topoisomerase 1 [Aeromonas salmonicida subsp. salmonicida A449]
9
MGKSLVIVESPAKAKTINKYLGKDYVVKSSVGHVRDLPTSGSGSNEPKKPVIRGIKLSESEKAAKDRNALFSRMGINPTAGWQANYQILPGKEKVVSELQSLAAKADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKTAIQEAFAQPSELNIHRVNAQQARRFLDRVVGYMVSPLLWKKLARGLSAGRVQSVAVRLIVDKEREIKAFVPVEFWDLNADLLTGDKSDLRMEVVSRNGADFKPVTQAETFAAVAALEGVDYKVVNREDKPTGSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVEALREYIGEQYGAAYLPAEPNLYGSKAGAQEAHEAIRPSSVLVTAEMLEGMEPDAMRLYDLIWRQFVACQMTPAQYDSSTLTVKAGEFELKARGRTLRFAGWTKALPPMGRKGEDSQLPAVTVGEVLKLIKLDPRQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIVDRGYVRVESRRFFAEKMGEIVTDRLVENFVELMNYEFTAKMEDKLDGIAEGSLEWKKVLDAFYEEFTQELAKADRDAEEGGMRANQMVLTDIDCPDCGRKMGIRTATTGVFLGCSGYALPPKERCKKTINLVSADEFVSATDGDEAETEALRAKHRCGVCGTAMDAYIIDDSRKLHVCGRNPDCDGYEIEKGQFKLKGYEGPSIECDRCGSEMQLKNGRFGKYMGCTNETCKNTRKILKNGDIAPPKEDPVPLPELKCTQSDAYFVLRDGAAGLFLAASNFPKSRETRAPLVEELKRFKERLSPKHQYLADAPASDPDGNASIVRFSRKTKEQYVMTEVNGKATGWTAHYDNGKWQESLAKSKKA
(692) DNA topoisomerase 3 [Aeromonas salmonicida subsp. salmonicida A449]
10
MRLFIAEKPSLGRAIADVLPKPHKKGDGFIETAAGDVVTWCIGHLLEQAEPDAYDAAFKQWRMEQLPIIPAQWQLVAKPKTKTQLTVIKRLIKLADCVVNAGDPDREGQLLVDEVIDFLGYPKTRPVQRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYTLLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFYEVLAHLVTDGNERFSAKWLPSEACLPWQDEEGRVLNRALAEKVVSRINGQPASVEEVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDVCQGLYERHKLITYPRSDSRHLPSEHFNRAAQVREAIAATAPALARAVSEADGKIRSKAWNDSKVDAHHAIIPTEKRGNESSLSGDEAKIYGLVARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGELLEKMTQAPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIIDLLFRRRFLVRQGKSIKGTPTGRALILALPTTATTPDMTALWEQSLGQIAERHASYQQFMGPLTDQLNALIEGARQDSGASFSALPKAVPGAGKPHFTRRKSSAGTTGTPRKSAGKRPAKSKAT
(1613) DNA topoisomerase 1 [Aliivibrio salmonicida LFI1238]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPMGSTSTGKKTAAASTKGMSVEDKARIKKERDKKNLINKMGIDPYNDWAANYQILPGKEKVVAELQKLAENADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKNAIQQAFETPGELSMPGVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVKVLVEREREINAFIPEEFWDIHADTLTSGKENFRLQVAQRNGSVFKPLNQADTESAVSILEKAEYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKEAVETLREFIGSEYGESYLPAAPIIYGSKEGAQEAHEAIRPSSVDVKVDDLQGMEADAHKLYNLIWNQFVSCQMTPAQYDSTTLSVKADEFTLKAKGRILKFDGWTRVQRPMGKNEDQLLPAVQLGDKLKLEQLDPKQHFTKPPARFTEAALVKELEKKGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLNQSFDDLMDYDFTARMEGNLDKIAEGSKDWKEVLNAFFQDFTDDIAKAELDESEGGMSPNNIVETDIKCPTCDRNMGIRTASTGVFLGCSGYALPPKERCKKTINLGNEEGIINVLEEDVETAALRAKKRCPKCETAMDPYLIDQDRKLHVCGNNPNCDGYIVEKGEFQLKGYDGPIVECDKCGSDMELKNGRFGKYMDCTSETCKNTRKILRNGDVAPPKEDPVHLPELECEKSDAYFVLRDGASGLFLAASTFPKSRETRAPLVEELVRFKDRLSPKFVYLTEAPTHDPDGKPAVIRFSRKTKENYVRTETDGKPSGWTALYLDGKWAVTDKRKKPKAEKES
(1718) DNA topoisomerase 3 [Aliivibrio salmonicida LFI1238]
10
MSRLFIAEKPSLGRAIAAGLAKPQKNHQGYIECGNGDIVTWCIGHLLEQVEPDAYDDKYKSWRMEHLPIVPEQWQLRPRKSSSKQLTVIRKLLKTASQVIHAGDPDREGQLLVDEVLDYLKLSKTKKAATQRLLISDLNLPAVKRALSAMRSNQEFIPLSISALARSRADWLYGMNMTRAYTLLGQRGGYQGVLSVGRVQTPVLGLVTRRDEEIAHFIPNAYFTLDALIPYHNPNLNGGLPFDIRAKWKPSEACQQWQDEDGRVLNLKLVENVAQRIANQPATVTKAENKETKQNAPLPYSLSALQIDASKRYNLSAQQVLDSCQALYEKHKLITYPRSDSRYLPKDHYKQREQVCAAIGNNDKQLSNAVNNADVNLRSRAWNDSKVDAHHAIIPTPKSSGAAGLSGYEEKVYHLIARQYLMQFYPAAIYAEAELIFDIAGGVFSAKGKQMLFAGWRILLGKTHTQNADDDVANKVPPLKKGEVHTCREGEIKHKMTEPPKYFTEATLLQAMTGIARFVEDKELKKVLRDTDGLGTEATRAGILDTLFKRQLLIRNGKNINASDAGKGLIHALPREATYPDMTAHWEFQLQGMTEKTYSYRPFMQSLETKVTNFMQGVQQGPVPDSLRSLKSPTKPQFKRRKSAKKS
(496) DNA topoisomerase 1 [Rickettsia japonica YH]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPNENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKAIIHAVENPRKLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTEKLKSQKFHVDKIEKKQQKRQPQPPFITASLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAQANGSTIAFDGFYKVYRESMDDKAEEANKMLPPLKEQEPLKTKKVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKPA
(1592) DNA topoisomerase 1 [Ehrlichia ruminantium str. Welgevonden]
1
MSLIIVESPSKAKTIGKYLGSKYKVVASFGHIRDFPAKSGSVDPDKDFAMTYEIIAKSEKYVSKLVQVANKETKEIYLATDPDREGEAIAWHIVEVLREKNAINNNIVINRMVFNEITKNAILASVKNPRNINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRENEIEKFITQEYWDIEAKLQNVEGREFSAYLKCYSGNKLEKFDIKNEEDANRLSAEIRQRSYSVSSVEKKHTKRNPYPPFITSSLQQEASTKLGFSAKSTMLIAQKLYEGVDIGGEIVGLITYMRTDGVYISDEAVEHIRSVISSMFGKEYLPESPRKYVKKIKNAQEAHEAIRPTNITITPDSLVSYLTQEQLKLYDLIWKRTVASQMNSAVLDQVIVELSSLDGIVILRALGSSLSFDGFYKVYGHDDDSKNSILPLLNENDHCPLNDVIPNQHFTNPPARYSEASLVKKMEEIGIGRPSTYASIISVLQDRQYVVLNQKRFFPTERGRVVNIFLVNFFNRYVEYDFTADLEEKLDLISNGKIGWKEVLHQFWFLFIDNVNSVKKLEFTQILNAISSEMESHIFPSDVSEVDKMCPVCNVGTLSLNISKNGVFLGCSQYPECKYTKNIGDSTVDNTEVSQYPRVLGSDAASGEDIYLKKGPYGIYLQIGSGKDGKRATLPKDIDLNLLDLEMAKKILSLPISLGMYPDTNSEIKLGLGKFGAYIFYEGKYFSIKKFEGNFLDITLENAIAIIQKNRTNGVIKSLGMSQDNKEVFLCKGRYGFYLKYDKLNIAIKKGIDVEQMSLVDALKLISEKL
(1593) DNA topoisomerase 1 [Ehrlichia ruminantium str. Welgevonden]
1
MSLIIVESPSKAKTIGKYLGSKYKVVASFGHIRDFPAKSGSVDPDKDFAMTYEIIAKSEKYVSKLVQVANKETKEIYLATDPDREGEAIAWHIVEVLREKNAINNNIVINRMVFNEITKNAILASVKNPRNINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRENEIEKFITQEYWDIEAKLQNVEGREFSAYLKCYSGNKLEKFDIKNEEDANRLSAEIRQRSYSVSSVEKKHTKRNPYPPFITSSLQQEASTKLGFSAKSTMLIAQKLYEGVDIGGEIVGLITYMRTDGVYISDEAVEHIRSVISSMFGKEYLPESPRKYVKKIKNAQEAHEAIRPTNITITPDSLVSYLTQEQLKLYDLIWKRTVASQMNSAVLDQVIVELSSLDGIVILRALGSSLSFDGFYKVYGHDDDSKNSILPLLNENDHCPLNDVIPNQHFTNPPARYSEASLVKKMEEIGIGRPSTYASIISVLQDRQYVVLNQKRFFPTERGRVVNIFLVNFFNRYVEYDFTADLEEKLDLISNGKIGWKEVLHQFWFLFIDNVNSVKKLEFTQILNAISSEMESHIFPSDVSEVDKMCPVCNVGTLSLNISKNGVFLGCSQYPECKYTKNIGDSTVDNTEVSQYPRVLGSDAASGEDIYLKKGPYGIYLQIGSGKDGKRATLPKDIDLNLLDLEMAKKILSLPISLGMYPDTNSEIKLGLGKFGAYIFYEGKYFSIKKFEGNFLDITLENAIAIIQKNRTNGVIKSLGMSQDNKEVFLCKGRYGFYLKYDKLNIAIKKGIDVEQMSLVDALKLISEKL
(794) DNA topoisomerase 1 [Rickettsia bellii RML369-C]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVIPDENFSMKYDISEKAGKYVDAIIKDAKKAESVYLATDPDREGESISWHIAEVIKEKNKVKSDDFFKRVAFNEITKKAITHAIENPRKLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMLNSNNELFTAKLTHINDQKLEKFSITNDKEAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVDEIRKLINKDYGDKYLPSSPRIYKSKVKNAQEAHEAIRPTNINYIPNDLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVNATLASENKEYLARANGSTIAFDGFYKVYRESIDDEAEEENKMLPPLKEQEHLKTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYATILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKSALGNFWNGFNHNIESVNKQNITEIISYVQQALDYHIFGENKDSKVCPSCKTGELSLKLGKFGAFLACSNYPECNFRKSIVSGNDNNEADGEAKDIVNENKVLGKDKEGIEIYLKKGPYGPYIQYGEQVDSKIKPKRSPLPAGLNQNDITLDMALKLLSLPLKIGNHKESGEEVLVGYGKFGPYIKYMGKFISIPKKYDFLNLSLDDAMKLIEEKLNAIAAKQPNPLNMDEVTNLVDKKIKVKKTKK
(932) DNA topoisomerase 1 [Rickettsia typhi str. Wilmington]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDKNFAMEYDISDKASKYVDAIVKYARKAEAVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICDREDEIERFKAEEYWDISLKMQNSNNELFTAKLTHVNDQKLKKFSIINEKEAKDLTRKLKLQKFYVEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGNKYLPINPRIYQSKVKNAQEAHEAIRPTNITYTPDNLKQKLEKDYYKLYELIWQRTIACQMENVIMDLVIANLASENKEYLAKANGSIIAFDGFYKVYRESLDDEDEEDNKMLPPLKAQEHIKTKEVIPNKHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKTSLNNFWSGFNNNIESVNEQKITEIINYLQKALDYHLFGENKESKVCPSCKTGQLSLKLGKFGAFLACSNYPECTFKKSIVSGNDNNEDEGNLSTILNDNKILGTDKDGVEIYLKTGPYGPYIQLGEQCGKVKPKRTPVPTNLKQSEITLEVALKLLSLPLKIGIHKDSGEEIIIGYSKFGPYIKYMCKFISVPKKYDFLNLNLDDAIKLIENNKAKLEKKHRSMV
(1052) DNA topoisomerase 1 [Orientia tsutsugamushi str. Ikeda]
1
MKLLIVESPAKAKTINKYLGSDFQVVASYGHVRDLLAKAGSVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATDPDREGESISWHIVEVLKEKKIFANFKRIIFNEITKKAIGDALQQPRDINLNLVNAQQARRSLDYLVGFSLSPLLWRKLPGCKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKLIEFDGNKLEKFSITNQSQAQDIVKNIENQQFKVIDITRKQRKKSPPPPFITSSLQQEAAGKLGFTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNFISSSFGSNYLPKQIRAFKSKVKNAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQRTVACQMENVILNLESINFASFNQLHVAKATGSTIAFDGFYKVYKEINDEEENKKLLPNLSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLGIGRPSTYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSIAKGMIEWQEILKNFWTGFNNNVQEIEQYKITDIIPQIETLLSNFLFPAQNDETDHKLCTLCKVGKLSLKLSKYGAFLACDNYPSCNFTRNIAAAFENNDNLPKGKNNKAIGYSDDMQKTIYLKEGPFGWYIQAGEDSTNKNDKPKRVPISVISSSPQDITLETAVKLLALPKVIGLNPNTNKEITVAVGRYGPYLKHDGKFISIPKNYDYLNLSINDCIKIITSSSSQLRKAKKDAPTNSDKVAKSKS
(508) DNA topoisomerase 1 [Anaplasma centrale str. Israel]
1
MMGVVIVESPSKAKTISKYLGGKYKVVASFGHVRDFPAKSGSVDPDDDFRMIYEIIPKSEKYIDKIVKAVSSEKSGIYLATDPDREGEAIAWHIIEVLRERSAIGGDVAINRMVFNEVTKRAVTAAISDCRSINMDLVHAQQARRVLDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLVCEREHEIERFDSKEYWNIEVLLKSKSGEELTAALKCYNGEKLDKFAIPNADSASAIAEHVRNGTYHVASVEAKRTKRNPHPPFITSSLQQEASTKLGFSAKNTMMVAQKLYEGIDIGGETVGLITYMRTDGFYISSEAISYIRDTIKMQFGEQYLTKSPRKYVKKVKNAQEAHEAIRPTDITMTPDSLAQYLSEDQLKLYDLIWRRTMASQMESAVIDQVIVDIQSKDGSVVLHAVGSSLGFDGYQRVYGTDDDDKRKMLPKLEAGEDCSLVEVSPSQHFTQPPPRYSEASLVKKMEEIGIGRPSTYATIISVLQERGYTQLEQKKFVPSERGRIVNAFLTNFFGRYVEYDFTANLEEELDLISNGNMAWKEVLRRFWDKFISDVSTVKGIEVSEILKSITKDLEEYAFSPNAGEAVNRSCPGCGEGELMLNIGKYKAFLGCNRYPECKYTRGVGGDSGVCRDEFPKVLGLDDATQEEIILKHGPYGEYLQLGDNAKGKRVAVPQGIQEITLDVAKKLLSLPITLGHYPNTAQDVKLGTGRFGPYVLYGGTYFSVKGREDFWNLTFEEAVNVIDSQAQKKSKLLGLHDNGKEIYVCKGRYGFYLKCDKKNVAIKGKGGDITLEDAVSLLNQKP
(534) DNA topoisomerase 1 [Anaplasma phagocytophilum str. HZ]
1
MGVVIVESPSKAKTISKYLGKKFNVIASFGHIRDFPAKSGSVDPSNDFKMIYEIIPKSEKHLDKIVKTVSAEKEAIYLATDPDREGEAIAWHIVEVLKEKCAIAKDVTVNRMVFNEVTKRAVTAAVDNCRPINMDLVRAQQTRRVLDYLVGFTLSPLLWRKLPGSRSAGRVQSVALRLLCEREYEVEQFKTQEYWDVGVDLQNQGGEKFEAVLKCYAGEKLEKFSIGTEEQAKEYAETVKNQSYTVESVESKKTKRNPYPPFITSSLQQEASTKLGFSAKNTMMIAQKLYEGIDIGGEIVGLITYMRTDGFYISEDAVNYIRDTIKMQFGEKYLSKSVRNYTKKVKNAQEAHEAIRPTDITMLPEQLSKYLTDEQLKLYTLIWKRTLATQMESAVIDQVAVDIKSSCGKISLHATGSTLSFDGYYRVYGSEDSDKRRMLPQLREGESCELLEVHPNQHFTQPPARYSEASLVKKMEEIGIGRPSTYATIISVLQERGYTQLEQKRFIPSERGRIVNAFLTNFFRKYVEYDFTANLEEELDLISNGKMVWKEVLSQFWDKFISDVSSVKTIEASEILKAITRDLENYAFSSVDGESISRVCPQCGSGELMLNIGKTSAFLGCNRYPECRYTRGIGGDGSASPADDASRILGIDEETQEEIFLKRGPYGEYLQLGNSTKRVSLTKSAGEITVDLAKKMLSLPLVLGCYPDTDKEIKLGIGRFGPYLFYNGVYFSIKDREDYINISHQEAVEIIDKQSDKKAKLLGQNKDGKDIYVCKGRYGFYLKCDKTSVALKGRSEDITLEDAILLLSQKQ
(1552) DNA topoisomerase 1 [Ehrlichia canis str. Jake]
1
MSLIIVESPSKAKTIGKYLGSKYKVVASFGHIRDFPAKSGSVNPDKDFAMTYEIISKSEKYVNKLIQVASKETHGIYLATDPDREGEAIAWHIVEVLKENNAIDDNVVINRMVFNEVTKNAILESIKHPRSINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRESDIEKFVTQEYWDIEAKCQNVEGKQFSAFLSYYAGKKLEKFDIKNEEDAKRLAEEVKSRNYSVVKVEKKHTKRNPYPPFITSSLQQEASTKLGFTAKNTMLIAQKLYEGIDVGGEIVGLITYMRTDGFYIADEALDHIRSIIVSIFGKEYLPASARKYVKKVKNAQEAHEAIRPTNITITPDSLSNYLTPEQLKLYDLIWKRTVASQMNSAIIDQVVVELASSDKVVTLRATGSSLFFDGFYKVYGHNEDDDNKNNMLPLLQVSDECPLNEVIPHQHFTIPPARYNEASLVKKMEEIGIGRPSTYASIISVLQDRQYVILNQKKFFPTERGRIVNIFLVNFFSRYVEYDFTADLEEELDLISNGKINWKKVLHKFWFLFIDNVNSVKKLEFTEILKVISCEMENYIFSSDKSETGRVCPACNDGTLGLNISKNGIFLGCSGYPECKYTKNVGGDLVDDVDNVQYPKVLGIDTATCQEIYLKKGPYGVYLQIGSDKNGKRAAIPKNMNANLLDLQMAEKILNLPISLGTHPETCKEIKLGLGKFGAYILYEGKYFSIKNESNFLDVKLEDAIDIIANSSTNGVIRSLGISEDNKEVLLCKGRYGFYLKYDKLNVALKKGTDVEQMSLSDAMKLISEKK
(1230) DNA topoisomerase 1 [Wolbachia endosymbiont strain TRS of Brugia malayi]
1
MALLIVESPAKARTISKYLSKEFKVAASFGHVRDLPVKNGSVDPDNDFAIKYEIIEKAEKYVKELVKEASQTSDIYLATDPDREGEAIAWNVIEALKERKAINDKSNIYRVVFNEITKRAVQEAVKNPREINMDLVRAQQARRALDYLVGFSLSPLLWTKLSGSKSAGRVQSVALKLICEREDEISKFVSQEYWSIRAEIKDSKGETFFAMLSHYDNKKLEKFDIKNEEEAKGLVKQIESRQYAVSTVERKQVKRNPLPPFITSSLQQDAVNKLYFNVKNVMRIAQDLYEGIDIGGETVGLITYMRTDGFYIADEAVNSIRRSIKSLYGNKYLPKSSRQYVKKVKNAQEAHEAIRPTDIDRTPDSIKDYLTPEQFKLYGLIWKRTIASQMESAILDQVVVEISSTDQKVILRASGSIIFFDGFYKVYKNNVDGEDESMIPTMKEGEECKLISVDPEQHFTQPPSRYSEASIVKKMEEIGIGRPSTYAAIISVLQDREYVTLDNKRFIPSSRGKIVTIFLETFFQRCVEYDFTAQMEEKLDLISNGRADWKKELGYFWVPFFNHVNSVKQMTHDEIFNGIRDLVVDWFCSEEGKKEVNKKCPDCPDGILKLNFGKAGVFLGCSNYPTCTHTKEITGSNDNSEYPKSLGIDGVTEQEVVIKKGPFGLYLEFNSESEKKKTVSIPKDINVNDIDLSTATRLLSLPKVIGEHPETGKEVKIGLGRFGYYIFYDSKYFSLKKSFKEVLEIQLDEAVQIIANSPRKELKSLGFNEKGKEVFICNGRYGFYIKCGKTNVALGKNADIESVDLRRALELIKSKK
(23) DNA topoisomerase 1 [Bradyrhizobium japonicum USDA 6]
1
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDANFKMIWEVDPKAAGRLNDIAKSLKGADRLILATDPDREGEAISWHVLEVLKEKRALKDQKIERVVFNAITKQAVTDAMKNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVPREYWSLIATLLTPRGDAFEARLVGADGKKIQRLDVGSGAEAEDFKKALEAAAYAVTAVDAKPARRNPQAPFTTSTLQQEASRKYGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDPSAITQARKVIGEDYGNAYVPEAPRQYQAKAKNAQEAHEAIRPTDMSRRPDSMSRKLDADQARLYELIWKRTIASQMESAELERTTVDITAKAGSRTLELRATGQVVKFDGFLALYQEGRDDEEDEDSRRLPAMSPNDALKRQSLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLHGEDKGRVVVAFLESFFNRYVEYDFTANLEEQLDRISNNEISWQQVLKDFWTGFIGAVDEIKDLRVAQVLDVLDDMLGQHIYPPRADGGDIRQCPSCGNGRLNLKAGKFGAFVGCSNYPECRYTRQLAADSETTADRSLGQDPDTGRDVWVKAGRFGPYIQLGEPKDYEEGEKPKRAGIPKGTSPGDVELELALKLLSLPREIGKHPETGQPITAGLGRFGPFVKHEKTYASLESGDEVFDIGLNRAVTLIAEKVAKGPSRRFGADPGKAIGDHPTLGTVTVKSGRYGAYVTAGGVNATIPAEFEKDTVTLPQAIALIDERAAKGGGKTKAKKAAKPAKAKKAAEKAADGDDAAPKPKKPAAKKAAKPKSESTSKARAAVSSTAKTSPTKAAAPKAPAKKSAGKT
(942) DNA topoisomerase 1 [Bradyrhizobium sp. ORS 278]
1
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPEENFRMIWEVDPKAAGRLNDIAKSLKGADRLILATDPDREGEAISWHVLEVMKEKRALKDQKIERVVFNAITKQAVSEAMKNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVPREYWSLIATLATPRGDTFEARLVGADGKKIQRLDIGTGAEAEDFKNALNAATYSVATVDAKPARRNPQAPFTTSTLQQEASRKLGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIAPEAITQARKVIGEIYGNKYVPDSPRQYQTKAKNAQEAHEAIRPTDLSRKPAELRKRLDDDQAKLYELIWTRTIASQMESAELERTTVDIVAKAGGRTLELRATGQVIKFDGFLALYQEGRDDEEDEDSRRLPQMSQGEALKRQNLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILDVLKARGYVKLEKKRLHGEDKGRVVIAFLENFFRRYVEYDFTADLEEQLDRISNNEIAWQQVLKDFWTGFIGAVDDIKDLRVAQVLDALDEMLGPHIYPPREDGGDVRQCPTCGTGRLNLKAGKFGAFVGCSNYPECRYTRPLAADSEAAADRMLGQDPDSGLEVAVKAGRFGPYIQLGEQKDYAEGEKPKRAGIPKGTQPSDVDLDLALKLLSLPREIGKHPETGLPITAGLGRFGPFVKHDKTYASLEAGDEVFDIGLNRAVTLIAEKVAKGPSKRFGADPGKALGDHPSLGPVAVKAGRYGAYVTAGGVNATIPGDKEKDTITLAEAIALIDERAAKGGGKAKAPKKAAKPKAAAKPKAGGDDDTPKPAKKAVAKKAAAKPKSDSTSKARAPVAKAAKTSAKPATKATPKKSAGKARG
(1368) DNA topoisomerase 1 [Bradyrhizobium diazoefficiens USDA 110]
1
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDANFKMIWEVDPKAAGRLNDIAKSLKNADRLILATDPDREGEAISWHVLEVLKEKRALKDQKIERVVFNAITKQAVTDAMKHPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVAREYWSLVATLLTPRGDAFEARLVGADGKKIQRLDIGTGAEAENFKKALEAAAYAVTAVDAKPARRNPQAPFTTSTLQQEASRKYGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDPSAITQARKVIGEDYGNAYVPEAPRQYQAKAKNAQEAHEAIRPTDMSRRPDSMSRKLDSDQARLYELIWKRTIASQMEAAELERTTVDITAKAGGRTLELRATGQVVKFDGFLALYQEGRDDEEDEDSRRLPAMSAGDGLKRQSLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLHGEDKGRVVVAFLESFFSRYVEYDFTANLEEQLDRISNNEISWQQVLKDFWNGFIGAVDEIKDLRVAQVLDVLDDMLGQHIYPPRADGGDIRQCPSCGNGRLNLKAGKFGAFVGCSNYPECRYTRQLAADSEATADRSLGQDPDTGRDVWVKAGRFGPYIQLGEQKDYEEGEKPKRAGIPKGTSPGDVELELALKLLSLPREIGKHPETGQPITAGLGRFGPFVKHEKTYASLEAGDEVFDIGLNRAVTLIAEKVAKGPSRRFGADPGKAIGDHPTLGTVTVKSGRYGAICHRRRRQRDDPGRVRKGHRHAAAGDRTD
(280) DNA topoisomerase 1 [Nitrobacter hamburgensis X14]
1
MFAPKPSAHLSRNRPRVFPLSYWNNMNIVIVESPAKAKTINKYLGASYEVLASFGHVRDLPAKNGSVDPDANFQMIWEVDPKAVGRLNDIAKSLKGADKLILATDPDREGEAISWHVLEVLKQKRALKDQKIERVVFNAITKQAVTDAMKNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCSREIEIEKFVPREYWSLIATLATPRGDTFEARLVGADGKKIQRLDIGSGAEAEDFRKAIEAANFIVSTVEAKPARRNPQAPFTTSTLQQEASRKLGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDGSAITQARKVIGEDYGNAYVPDAPRQYQTKAKNAQEAHEAIRPTDLSRRPADMKRRLDADQARLYELIWIRTIASQMESAELERTTVDIAARAGSRVLELRASGQVIKFDGFLALYQEGRDDEEDEDSRRLPAMSDGEALRRENLSVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLYGEDKGRVVVAFLENFFARYVEYDFTANLEEQLDRISNNEVSWQQVLKDFWNDFIGVVNEIKDVRVSEVLDVLDNMLGPHIYAPREDGGDPRQCPTCGTGKLNLKAGKFGAFVGCSNYPECRYTRPLAADGEAGGDRILGKDPESGLDVTVKSGRFGPYIQLGEPSDYGEGEKPKRAGIPKNTSPADMELDLAVKLLSLPREIGKHPETGEPITAGIGRFGPFVRHEKTYASLEAGDEVFDIGLNRAVTLIAEKIAKGPSRRFGADPGKPLGEHPTLGSVAVKSGRYGAYVTAGGVNATIPSDKTQDTITLPEAIALIDERAAKGGGKPKRAAKKAKSAGTERTGKAGAVAAKPAKKAAAKQASVKPKSAAVSKARGSIAAVKPPAKAEKAPAKKSAGKNG
(225) DNA topoisomerase 3 [Vibrio parahaemolyticus RIMD 2210633]
10
MSRLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERYKKWNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCKLSKTKKEATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDQNGAFDIRARWKPSEACKPWQDEEGRVLNRKLVENVANRIANQPAIVKESEQKQTKQSAPLPYSLSALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPLEHYSQAGTVTSAIANNAKELQSAVNGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQFYPAAVYAEAKLVFDIAGGIFIAKGRQLVSPGWKALMGKTDKEDEGIDTVPPLSEGTVLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGILDTLFKRQLLTRQGKSILSSQAGRGLINALPQDATYPDMTAHWEHQLQGMAERNQAYQPFMQALEQRIDGLMSQVKSGPIPDSLRHLPKVERPAFKRKKRSYPNSGASKAGASKRKSS
(1253) DNA topoisomerase 1 [Vibrio parahaemolyticus RIMD 2210633]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQSTGEKKAAAISTKGMSAEEKARVKKEKDRKALIKKMGINPYHDWEANYQILPGKEKVVSELQKLAKDADCVYLATDLDREGEAIAWHLREIIGGDEERYKRVVFNEITKNAIQQAFQTPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFVPEEFWDIHANTKTKDKSDFKLLVAQKDGVAFKPVNETETKAAISVLENASYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVDAVRDFIGSEFGDKYLPAKPLTYGSKEGAQEAHEAIRPSDVSVKAEDLQGVDADAHKLYSLIWNQFVACQMTPAEYDSTTISVKAAEYTLKAKGRILKFDGWTRVQRPMGKNEDTILPAVQLGDKLSLESLDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEQKLDQIAEGEVNWKAVLDNFFADFTGDLEKAELDESEGGMKLNHIVMTDIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEEGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYVVEYGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHFPELPCENSDAYFVLRDGASGLFMAASNFPKSRETRAPLVSELARFEERLPEKFKYLTTAPQEDPDGRPAVVRFSRKTKENYVRSEDDGKPSGWTALYVDGKWEITDKRKKAKA
(612) DNA topoisomerase 3 [Vibrio anguillarum 775]
10
MTRLFIAEKPSLGRAIADALPKPHKKDQGFIRCANGDIVTWCIGHLLEQVEPDVYDERYKKWNLLDLPIIPSQWQLRPRKTSSKQLTVIRQLLKEASQIIHAGDPDREGQLLVDEVIDYCKVSQSKKEQALRLLISDLNLPAVQRALKQMRSNREFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPILGLVVRRDEEIENFIPRDYFTLHALIPYQTDQVAFDIRARWKPSDACQPWQDEEGRVLNRKLVENVAQRIAGQPATVIEAEQKQTKQAAPLPYSLSALQIDAAKRFAMSAQQVLDTCQSLYEKHKLITYPRSDCRYLPQEHYAQASSVTQAIACNAKELLTSVSGANLALKSKAWNDKKVDAHHAIIPTPKQTSVNALSGNEMKIYQLIARQYLMQFYPAAVYAEAKLVFDIAGGFFVASGRQLVDTGWKSLLGKVDEEENGVDAVPPLSKGTVLTCREGEIHDRKTEPPRHFTEATLLQAMTGIARYVEDKELKKILRETDGLGTEATRAGILDTLFKRQLLTRQGKLILSSPAGRGLIHALPNESTYPDMTAHWEHQLQAMAERGQAYQPFMQVLQERIIQIMEQAKSGAVPESLRSLPKVERPAFKRKTRKSSKTTRYQRNSAQ
(1695) DNA topoisomerase 1 [Vibrio anguillarum 775]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQSTAKKATSSSSSKNLSAEEKARLKSEKDRSSLIKKMGIDPYHGWEANYQILPGKEKVVAELQKLAKDADCIYLATDLDREGEAIAWHLREIIGGDEQRYKRVVFNEITKNAIQQAFQTPGELNIDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFVPEEFWDIHADTKTQDKTDFRLLVAQKNDVAFKPVNEAEAKSAVSILEKASYEVCKREDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVEAVRSYIGSEFGQAYLPENPLAYGSKQGAQEAHEAIRPSSVDVKADDLQGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEFTLKAKGRILKFDGWTRVQRPMGKNEDQILPPVKVGETLLLQTLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEEKLDQIAAGSANWKGVLDDFFKDFTADLETAELDEEQGGMKPNHIVMTDIQCPTCSRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEEGVINVLEEDVETAALRAKKRCPICETAMDAYLIDDTRKMHVCGNNPNCEGYVVEFGEFKVKGYDGPVVECDKCGSNMVLKNGRFGKYMDCTSDDCKNTRKILRSGEVAPPKEDPIHFPELPCENSDAYFVLRDGASGLFLAASNFPKSRETRAPLVEELARFKERLAPKYQYLADAPAHDPDGVAAVVRFSRKSKEHYVRTEIDGKPSGWTALYDNGRWEITDKRKNAKK
(1115) DNA topoisomerase 1 [Polymorphum gilvum SL003B-26A1]
1
MESPAKAKTINKYLGSGYQVLASYGHVRDLPAKDGSVKPDEDFAMSWEVDSKSQKRLNEIAAAVKDADRLILATDPDREGEAISWHVLEVLHKKRVLKDKPVERVVFNAITKQAILEAMKHPRAIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLICDREMEIETFVKEEYWSILANLKTPSAEVLQAGLTGFDGRKIGRLDIKTGDEAETIRRMLEAARYTVASVVSKPAKRHPQPPFTTSTLQQEASRKLGFAAARTMQVAQKLYEGVAIGGETTGLITYMRTDGVQIAGEAISATRKVIGQDFGDNYVPEKPRFYSSKAKNAQEAHEAIRPTDLARRPRDVARFLDPDQARLYELIWKRTMASQMESAVLERTTIDIDAAGAGKTATLRATGSVVRFDGFLALYQEGRDDEEDEAARRLPAVDDGAPLALAAVEGKPSAIEADQHFTTPPPRYTEASLVKKMEELGIGRPSTYASTLQTLRDRDYVAFDKKQLVPQDKGRIVTAFLESFFNRYVEYDFTASLEEQLDRISAGELSWREVLANFWRDFSASVDETKDLRVSQVIDALNDLLAAHIFPPREDGKDPRACPTCATGQLSLKVSRFGAFIGCSNYPECSYTRQLARNGDGEGEDAASDGPKVLGTDPATGLEVSLRSGRFGPYVQLGEDAKPRRSSLPRGWSAADLDLARALQLLSLPRDVGAHPEDGKMITAGLGRYGPFVQHDGTYANLGSADEVFSVGLNRAVDLLAEKRSKTGRGRATPAALKELGEHPSAGGPITVRDGRYGPYVNWAKVNATLPKGSDPMAVTLEQAVELIAAKGGGKAAPKKAATKKPAAKKPAAAKKSASRTKAKAGGAAADGTS
(499) DNA topoisomerase 1 [Caulobacter crescentus CB15]
1
MNVVVVESPAKAKTINKYLGSDYTVLASYGHIRDLPSKDGSVEPDNDFAMSWEVDAKASKRVSDIVDAMKKADRLILATDPDREGEAISWHVLEVLNKKKALKDKTVQRVTFNAITKTAVTEAMKAPRDLDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVVDRELEIERFKTQEYWTVDADVSAGSDPFLARLVKHEGKKLTKFDLGNETSALTAKAAVEAAVFKVEAVEKKPGKRSPAPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVSMAPEAIFEARDVIGAVYGKEYVPDSPRMYKSKAKNAQEAHEAIRPTAMGRNPGSLRLEPELGRLYELIWKRTIASQMESARIERTTVDLTSADGQTGLRATGQVVQFPGYLAVYEEGRDDEGDEDSARLPAITEGASAKVLKSRADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASVLGVLRDREYVRMEKQRFIPEDKGRLVTAFLEQFFKRYVEYDFTAALEEKLDLVSDGKLDWKEFLREFWKDFHAAVGEIAELRTTNVLDALNEALGPHIFPDKGDGSNPRLCPTCGSGQLSLKTGKFGAFIGCSNYPECRYTRQLGVSEGDGDAESADKQLGLNPATGLAVWLKNGRFGPYVEELAAEGSSDKPKRSSLPKGWIASAMDMEKALRLLSLPREVGKHPDDGKVITAGLGRFGPFVLHDGTYANLENADEVFDVGLNRAVAILADKRAGGGRPQRGAAAALAELGNHPEDGKPIRVLSGRFGPYIKHGDTNANVPKGKDPAAITLEEALALIAERAAKGGAKKPAKKAAATKSKAKAESDAPAKKTAAKKPAAKKPAAKKAAPKAKAKATAASDDGAAPWDDEG
(1277) DNA topoisomerase 1 [Caulobacter segnis ATCC 21756]
1
MNVVVVESPAKAKTINKYLGSDYTVLASYGHIRDLPSKDGSVEPDNDFAMSWEVDAKASKRVSDIVDALKKADRLILATDPDREGEAISWHVLEVLNKKKALKDKSVQRVTFNAITKTAVTEAMKAPRDLDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVVDREIEIERFKTQEYWTVEADVSAGSDPFLARLVKHEGKKLTKFDLGNETSALAAKAAVQAAVFKVEAVEKKPGKRSPAPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVSMAPEAITEARDVIGKVYGKEYVPDVPRLYKSKAKNAQEAHEAIRPTSMGRNPGSLRLDPELGRLYELIWKRTIASQMESARIERTTVDLESADGKTGLRATGQVVQFPGYLAVYEEGRDDEGDEDSARLPAIVEGSPAQVREARADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASVLGVLRDREYVRMEKQRFIPEDKGRLVTAFLEQFFKRYVEYDFTAALEEQLDLVSDGKLDWKQFLRDFWKDFHAAVGEIAELRTTNVLDALNEALGPHIFPDKGDGSNPRLCPTCGTGQLSLKTGKFGAFIGCSNYPECRYTRQLGVSEGDGEAESADKELGVNPATGRAVWLKNGRFGPYVEELAAEGDKPKRSSLPKGWIASAIDLEKALRLLSLPREVGKHPDDGKVITAGLGRFGPFVLHDGTYANLENADEVFDVGLNRAVAILADKRAGGGRPQRGAAAALAELGNHPEDGKPIRVLSGRFGPYIKHGDTNANVPKGKDPAAITLEEALALIAERAAKGGGKKPAKKAAASKAKAPTKAEGDKPAKKTAAKKPAAKKTAPKAKAKAPAASDDGAAPWDDEA
(1848) DNA topoisomerase 1 [Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]
1
MKLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGSVNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLSPILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQMASAKLERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRADQHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEPWLFPDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYPECKYTRGFGQGEDGVDDNEPVLLGYMPENSDDDGYMAFSDQGDILPANTASASETGVTDGGIAANAAFSGKGNSASHTDRDDLPFDPDEPASSTGNVASSQSRMTGDETASSGNSRDSSAHGVSTTAGIDAESQAGISNQALAGKNNAGRTAVSDNKGNNSSSTIAAARKGGSTDDNATVSDPDGDIGSGASSSGQDADNRLLSHRNGDIDSRAIPADHKDSSSDQNASHALSPDRNSDDASVSNSDKKIDSKAVSTGHDVGNAITSDNSPSDNVAHLASTPSSATSSVKVALETENNDTAASKADEQAKEEEESRKARAVTRRTGRFGPYIQLGEGKNAKRVSVPRDVNPREVDFSLASRLLALPREIGLHPESGKMIIAGTGRYGPYLNCDGKYARLSSTEELLDIDIDRAVVKLAEAAQNKGRTGATLSREPLKVFGDSPVTEKPVQLMNGRYGPYVTDGETNASLPKDTTPESLTFEEALALLEARAKMPKKKKTKKAAAKKPAAKKTTTKKAAPKKATTKTATPKSATTDNATSEDGDATPAKSPAKKAVAKKTTAKKPASKSATKKAPSSKTTAAKKTSKATPKDEVAE
(1847) DNA topoisomerase 1 [Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]
1
MKLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGSVNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLSPILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQMASAKLERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRADQHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEPWLFPDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYPECKYTRGFGQGEDGVDDNEPVLLGYMPENSDDDGYMAFSDQGDILPANTASASETGVTDGGIAANAAFSGKGNSASHTDRDDLPFDPDEPASSTGNVASSQSRMTGDETASSGNSRDSSAHGVSTTAGIDAESQAGISNQALAGKNNAGRTAVSDNKGNNSSSTIAAARKGGSTDDNATVSDPDGDIGSGASSSGQDADNRLLSHRNGDIDSRAIPADHKDSSSDQNASHALSPDRNSDDASVSNSDKKIDSKAVSTGHDVGNAITSDNSPSDNVAHLASTPSSATSSVKVALETENNDTAASKADEQAKEEEESRKARAVTRRTGRFGPYIQLGEGKNAKRVSVPRDVNPREVDFSLASRLLALPREIGLHPESGKMIIAGTGRYGPYLNCDGKYARLSSTEELLDIDIDRAVVKLAEAAQNKGRTGATLSREPLKVFGDSPVTEKPVQLMNGRYGPYVTDGETNASLPKDTTPESLTFEEALALLEARAKMPKKKKTKKAAAKKPAAKKTTTKKAAPKKATTKTATPKSATTDNATSEDGDATPAKSPAKKAVAKKTTAKKPASKSATKKAPSSKTTAAKKTSKATPKDEVAE
(566) DNA topoisomerase 1 [Novosphingobium aromaticivorans DSM 12444]
1
MQLVIVESPAKAKTIEKYLGPGYKVLASYGHVRDLPVKDGSVRPDEDFAMDWELYGDKQARVKAISDAAKGADRLILATDPDREGEAISWHVRELLAKRRVLPKEVERVTFNAITKQTVTDAMKKPRALDQDLIDAYLARRALDYLFGFTLSPVLWRKLPGAKSAGRVQSVALRLIVEREREIEAFRAQEYWSVIARLEHAGTEFAARLVKFDGQKLDKLTLGDEGAAMRAKGVVEAATFRVEEVETKPTRRNPYPPFTTSTLQQEAARKLGFSASHTMRVAQTLYEAGAITYMRTDGVQMDPSAISAARKAISDRYDGHYLPEKPRHYETKAKNAQEAHEAIRPTDFSKDRYGSADEARLYDLIYKRAMASQMASANIERTTVTLRDGTGKHELRATGQVVKFPGFLAVYEEGRDQKQDGDEEDGSLLPAMASGDTPAKRGVDATQHFTQPPPRYSEASLVKRLEELGIGRPSTYAATLQVLKDRNYVRTEKNRFFAEESGRLLTAFLERFFPRYVAYEFTAGMEEELDDVSGGRAEWKKVLADFWRDFKPKSDEVMEKKPSEVTAELDEFLSDYLFPPRADGTDPRLCPKCEEGRLSLRGGRYGAFVACSNYPECKYTRKFAQPGGADGDGGEDGALGKDPETGLEVVRKAGRFGPYIQLGDGKEAKRASIPKDIGELDLEWALKLLSLPREVGVHPETGNPITASIGRYGPYLAHDGKYARLKSTAEVFETGMNAAVMLLAAAAAGAGARGSRAAAEPLKVFGAHPTSGGEIKLMAGRYGPYVTDGTTNATLPRDKQPEALTLEEAITLIDERAAKGPAKGKKKAPAKKASAAKKPPAAKKAPAKKAAPKKAAAAE
(1132) DNA topoisomerase III [Azospirillum sp. B510]
3
MATLIITEKSSQAKDLRAALGDRFGRILPAEGHLLRLAEPDEVDPAWKRWSPTLLKPDGLYPTRPDQGGNKAAKLQAITTALRACDEVILATDCDREGQLIGQEILEHVGYRGKVRRALFTAQDPKTLRDAFAALKPNDSMRPLYEAAVARQQADQIYNLSLTRTATKTLLAPGTRGVIGIGRVKTPTLAIVCLRELEIRDFKPEDYFEVVATANVAEGRFLMRHAPAPKDRIKDRATAEAIARAADQHRGPLTVTVEEKRQAPPRLYDLPSLQKTCGQRWGWTADRTLAVAQELYDGDGKKLITYPRAEARYLSENQIGDAPAIVGALTRLRGFAHLGEHMDVRRPVIRKGKSGHFCDKALEGVSHHAVIPNVNVLDDLESRLGRLSDDEKRLFALICRSYLAAVMPDYEYRQTGVTMPVPVPPPEGARTEGAKPVAFRAVGRIPLKLGWKAAFGSAETEDRSGGKPEEEAEQTLPPLRDGEPATLTDPKVEAKRTQAPPRYNEGTLVDAMQNAWRFVEDPALRDRLKEAKGIGTPATRAEVIKGLRKQNLLGADGKWLVPTPAGLHLFETLRAAAPTLVDPGTTALWEMKLDEVVTGRADFRGVIDAIAGEADRLIGALLGQRGTMLDLGQPAAKTRFTRRRTGATRAASAQTGAPAAPKGRRTRKATVVPADGAAMPPKPRRTRKAKEAAVAPPVTGSAVAQPMESQAGPEARRRREPTERMVAFARSLAERKGIALPDPCLRDFERCRSFLDEHAR
(187) DNA topoisomerase 1 [Azospirillum sp. B510]
1
MPGSNVVIVESPAKAKTINKYLGDDYTVIASFGHVRDLPARDGSVRPDEDFAMEWELGDRSKRHIDEIAKAVKSADRIYLATDPDREGEAIAWHLSELLREKHLSDNRDVQRVTFNEITKSAVQTAMANPRAVSQELVDAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICERESEIEVFKPQEYWSIAVGFTTPSGSAFTASLTQLDGKRLDKFGLPNREAAEAAVAKILPRSFAVSSVERKQSRRNPSPPFTTSTLQQEASRKLGFGATRTMRTAQKLYEGVDIGGETVGLITYMRTDGVSLSQEAIDGARGLIGSHYGERYVPDQPRVYKTAAKNAQEAHEAIRPTDLHRRPETVAAYLEQDELRLYELIWKRTLASQMESAVLDQVAVDIASPSDNGAKAVVLRATGSIVVFDGFLKVYQEDRDDAAEDEQQERRLPAMDQGDALARGDIAQDQHFTQPPPRYSEASLVKKLEELGIGRPSTYASILQVLQDRNYVRLDKRRFIPEDRGRLVTAFLENFFHRYVEYNFTAELENQLDEISDGKIDWKTVLRDFWTAFDVAVNGTKDLTITQVLTTLDNELGAHFFPAATEGGHDPRVCPVCREGRLGLKLGKMGAFIGCSRYPDCRYTRPLAVANDENGEAQEGPRELGNDPETGLPVTVRRGPFGAYIQLGPAPAAATPPEEPAAEEPAADGKKPKAKKKKKDEAPKPKRVSLPKGMAAADVDLDTALRLLALPRAIGNHPETGEEISAGIGRFGPYLKHGSVYKSLTADDDVLTIGINRAVDLLAGAAKKASAPAKTLGDHPKTGKPITMGSGRFGPYVKHASVYASIPKGTEPDSVTLEQALELIEAKVAKDAAKKGKAPKDAEPAKAEGAEAEKPAKAKVPAKKPAAKKATKAKAAKDAPAETAAPKKKTVKAS
(1111) DNA topoisomerase 1 [Hyphomonas neptunium ATCC 15444]
1
MKLVVVESPAKAKTINKYLGKDYKVLASYGHIRDLPSKNGSVDPENDFEMVWEADSKSAKRISDIANALKDADTLILATDPDREGEAISWHLVEALRKRRALKKDVAIERVVFNAITKSAVTQAMEHPRAIDAELVDAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRIVCDRENEIESFRAQEYWNIVAELRAPDGTAFEARLHSLDGETLKKFTLGNQGDANRALEIVKVGGYSVVSVEAKPVKRNPPPPFITSTLQQEASRKLGFNAKRTMQAAQKLYEEGRITYMRTDGVNMAEEAYVAARTMIQSNYGARYLPENTRRYSSKAKNAQEAHEAIRPTDFNLRPEDYHGDGDLKKLYTLVWRRAVASQMETALFERTTIDLASKDKRAGLRATGQVLVFDGFIKLYTEGHDAGDDDDDAEGRLPKMAEGQHADLLKADANQSFTQPPPRYTEASLVKRLEELGIGRPSTYASTMSTLEDRGYVRIEGKALVPEDKGRLVTAFLENFFSRYVEYDFTAGLEEKLDVISDGKLDWKAFLREFWQQFAADIDGTKDLRVSAVLDALNEALGAYVFPRQDAEGNPIENPRQCPLCKEGELSMKLGKFGAFVGCSRHPECKYTRQFSSEGGDAAINPDGNEIGIHPDTGAMILLKSGRFGPYVEMANGEKPKRASLAKADNAAELTLERAVELLSLPREVGPHPEDGEMILANFGRFGPYVQHGKTYANLKDPRDVFTIGVNHAVSLIEDKKARGSARGGAAALKALGDHPDGGAIEVFEGRYGPYVKWGKVNATLPKEITPDVVTLEQAIELVNAKGGSAKKKAPAKKAAAKKPAAKKAAPKKKAPAKKAEE
(1028) DNA topoisomerase 1 [Hirschia baltica ATCC 49814]
1
MQVVVVESPAKAKTINNYLGKDYIVLASYGHIRDLPSKDGSVDPDADFAMKWEGDSKSNKRIKDIADALKGADGLILATDPDREGEAISWHVLDVLSKKRGLMKDKKIERVVFNAITKKSILEAMQNPRSLDQELVDAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRLICEREVEIEAFKPEEYWTIKGLMDSVSKTEFEARLYELEGKKTQKFSFPNKEAADKALEVVRVGGYTVQSVEAKPVKSNPPPPFTTSTLQQEASRKLGFNASRTMGAAQKLYEAGLITYMRTDGVEMAQEAIHAARDAIKERYGAPYVPSSPRIYTSKAKNAQEAHEAVRPTDFLKHPSEVRLEADLQRLYDLVWKRAVASQMATAQLERTTADLKSKDGQAILRATGQVVKFDGFLTLYQEGKDDANGDEDAKRLPAMSVGDVIDLKKADANQSFTQPPPRFTEASLVKKMEELGIGRPSTYASTLATLRDRDYVEMDKNRFVPADKGRLVTIFLENYFNQYVQYDFTAELEEKLDLVSDGKLEWKVFLAEFWKQFSLKIAEVMELRVTNVLDLLNDVLGPKIFPPKLDEKTGEPTGEDPRLCPLCKEGQLSMKLGRNGAFIGCSNYPECKHTRPFTTDGSDAEDAVSPDGKLLGQDPETGKDISLRTGRFGPYVQLGEGIGKEKPKRGSIPKGWKADELTLAQAIQLINLPREIGPHPEDGEMMYANFGRYGPYVQHQKTYANLPDPMDVFEVGLNRAVALIAEKNAKGGRGGAAKALKELGKHPDTDEPINVFDGRYGPYVKHQKTNATLPKDLTPETITLEKAIELINAKAGASKKKAPAKKKAPAKKTAAKKAPAKKAPASDS
(1756) DNA topoisomerase 1 [Parvularcula bermudensis HTCC2503]
1
MQVVIVESPSKAKTINKYLGSDYKVLASYGHIRDLPSKNGSVDPEADFSMIWESDARSKKHVSDIVDAVKAADGVILATDPDREGEAISWHLLEVLDKKKALKDKSIQRVAFNAITKRAVEEAIANPRTIDQDLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLICERELEIEKFIAEEFWTLEANVSADDSPQFAARLVKLDGTKVEKFTLTTEEDGSRAKKAVEDAQFLIKSVEAKPTRRNPAAPFTTSTLQQEASRKLGFNARRTMQTAQRLYEGITIGGETTGLITYMRTDGIDMAPEAVMAVRDEIKSTFGADYLPSSPRMYKSKQKNAQEAHECIRPTNFARHPDALKQLDQDQYRLYDLIWKRAMACQMETARLEQTTIDIESRDGKTGLRATGSVVVFDGFLKLYAEGRDDTEDEKDRSLPKVSEGSDAQVTDPTPEQHFTQPPPRFTEASLVKRLEELGIGRPSTYASIISTLQDRSYVTMDKNRFIPDDKGRIVTAFLENFFGRYVEYDFTAKLEETLDDISNGEMAWKAFLRRFWDEFHARVEDMSDLRISEVLDALNEALGPHIFPQREDGRPPRECPTCGEGELSLKVGRYGAFIGCSRYPECKHTRPLGQSEQGNAPAEDRQLGVDPDTSQAVWLKSGRFGPYVQLGEPDPDTKEKPKRSSIPKSWDAASLDFDKAMKLLALPRDVGPHPEDGEMIEASLGRYGPYVKHGKLYANLESIDDVFDIGINRAVAVLEDKKANPRGRGRSAAKPQRELGNHPDTDELVAVYDGRYGPYVKHQKTNATIPQGVDPAEITLEQALELISAREAKKPTKKKKTAKKKSAKKPAKKKTTKKAAKKATKKTTNSAGKD
(1811) DNA topoisomerase 1 [Magnetococcus marinus MC-1]
1
MTAVVIVESPAKAKTINKFLGRGYKVVATYGHIRDLPSKNGSVDTEHGFAMKYSVPKDSTKRVDELAKAVKGAEQVLLATDPDREGEAISWHVYEVLNEKKLLENVQVKRVVFHEITKTAIQDAVAHARDVDMDMVNAQQARRALDYLVGFNLSPLLWRKVRRGLSAGRVQSVALRLVCEREAEIQAFEAREYWSITALAAQAAQSAPRPFEARLAVADGEKLSKFSIGDEAYAKRLIKAVEKRPLYVSEIEKKQSKRNPAPPFITSTLQQEASRKLGFSAKKTMTVAQRLYEGMEVPTADGGKETVGLISYMRTDSVNLANEAIESIRKQIEIRYGKEYLPKSPRKYKSSAKNAQEAHEAIRPTDVIRTPEMLREILEKDQFRLYELIWKRTVACQMAQAKIDKVAANLSVDSQDPNAAYRFRATGSSVAFAGFMKVYMEGKDEVSAQDREDDDDDNESILPPLEVGQQLEQKSLDARQHFTEPPPRYTEATLVKVLESYGIGRPSTYAPTMSTLQDRGYVKLDARKFYPEDVGMVVNSYLTKHFSTYVDYNFTANLEDQLDAVSRGEKSWVPLMEDFWQPFIQQITLKDETTSKEEVTTEQIDEPCPKCGAPLSIKLGRFGKFKACTGYPECKHTEPLNKEEEVSRPEPELTDIPCDKCGKPMLIKEGRYGKYYGCSGAPECKNNQPLNKPRDTGVACPSCGQGTFLEKKSRRGKIFYSCSNYPKCKQALWDEPLEIPCPKCQAPFVTKKVTKTRGTEHICVAEGCDYKEVVEAPIKTSKQ
(654) DNA topoisomerase [Magnetococcus marinus MC-1]
4
MILYLCEKPSQGRDIGRVLGATSRHEGYVAGAGVCVTWCIGHLMEMVAPDGYRPEWKSWRLDTLPIIPQQWQLELTARGRKQFKVIQGLLKGVTEVVLATDADREGETIGREVLERCQYRGKISRLWLSALDDASIRKALGNLLPGEQTEPLYQAGLGRSRADWMVGMNLTRAYTLLGRQGGYAGVLSVGRVQTPTLKLVVDRDRLIENFKPVDYFEIFALHRVHSGTFIAKWVPPPKPCDAEGHCLDRTLAETVIHKVQGHSGTITKAETKRVKEPPPLPLELSTLQQEASRRWGMGAKQTLEIAQSLYEKHKAVTYPRTDCRYLPSNQFKEAPAVLQGLTTNDASLTPLVEGADAQLRSKAWNDKKITAHHAIIPTAAKINIDALSREEALLYDLIRRHYLAQFYPPFEYDRTVIDTQVAMETFHATGRVELIPGWKRVLAANQEKKEGDEDEQTLPVVRSGEAATIEGAELKQKQTKPPNRYTEGTLIQAMKSVGKLVEDARLRKILRETSGIGTEATRAAILETLIKRNLLAKQGKKSLVSMPAGRLLVDALPHSVTDPATTAVWEQTLDDIAHGGGSLETFLAKSELWLNKLIHNVHQRQQLGLNPFRGLPPSTSHTDPAQPTPRRQRRSKAEVTPTPNAAPLCPQCGGPMLQRKSPQGAFWSCAEQATCTGTRPGSPLAAHSPLMQPNPERGPLCPKCQQAPLVQRTAYRGKNSGQPFWGCQRYPQCRYTQASQTTES
(121) DNA topoisomerase 1 [Maricaulis maris MCS10]
1
MNVVVVESPAKAKTINKYLGADYTVLASFGHVRDLPAKDGSVKPDEDFEMAWEIDTASAKRVKAIADAVRESDRLILATDPDREGEAISWHLLEALQKRRVLKDVTVQRVAFNAITKPAILEAMAHPRAVDMELVNAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICDRELEIEKFRSEEYWTVDADLTANSDSFRAKLVTLGGKKLQKLSIKDRASANAAVEAVNSANLSITGVEAKPAKRNPPPPFTTSTLQQEAARKLGFSATRTMQTAQKLYEGVTLGGETTGLITYMRTDGVTMVPEAVSQARDVIGKEHGSLYVPSAPRHYASKAKNAQEAHEAIRPTSFSRLPEKLSLDADMARLYQLIWRRAVASQMESARFERTTVDIASPDGQTALRAVGTVQLFDGFLALYQEGRDDEEDEGENRLPKLTQGAAATVAKTHADQHFTQPPPRFTEASLVKRMEELGIGRPSTYASTLQVLRDREYVQMEKNRFHPFDKGRVVIAFLENFFARYVEYDFTASLETQLDKVSAGELDWKQLLRDFWTDFRAAIDEIGELRITNVLDALNEALAPHIFPEKEDGTDPRLCPSCKEGTLSLRLGKFGAFLGCSNHPDCSFTRQMSPPGEDDAQGDRVIVQHPETGKDVELKNGRFGWYLQMQLDGEDKPKRSSIPKGWDAATLTEEQAIKLIDLPRTVGEHPDDGQPITANIGRYGPYVHHDKTYANIPSVEEVFEIGLNRAVSVIADKRANGGRRGATASALKELGEHDGKPVRIMSGRYGPYVKYEKINATLPKDTDPESVTLEQAMEWVEAKAAKGGKKKAPAKKKAPAKKKAPAKKATAKKPAAKKTAAAKDKAE
(700) DNA topoisomerase 1 [Granulibacter bethesdensis CGDNIH1]
1
MPHDVAIIGILMTDVVVVESPAKAKTINKYLGGNYTVLASFGHVRDLPPKDGSVRPDQDFAMDWEADERGRKQVAAIAKALKGAETLYLATDPDREGEAISWHVRAMLEEARALKGVEVRRITFNEITRNAIRHAIEHPRDLDQPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFRPREYWTVETHFFTPAGAPFTARLTHLDGKKLDQFDLNTEALAMRARALVEQGQFHVGMIERKKVKRNPPPPFTTSTLQQESSRKLGFGAQATMRLAQQLYEGVEIGGETVGLITYMRTDGVQMAREAMFSIRDHVKDSYGLDYLPAAPREYSSKAKNAQEAHEAIRPTDVERTPDSVARYLNPEQRRLYELVWKRAVASQMQSAELDQVTVDIFPQTGDAKSVQLRATGSIIAFDGFLKLYREGQDDTEEEEGRMLPPMAERDPLRQDRVDASQHFTQPPPRYSEASLVKRMEELGIGRPSTYASILSVLQDRNYVRLDKRRFHPEDRGRLVTAFLTSFFERYVDTNFTASLETQLDEISDGRADWRQVMQAFWQDFYQAVEQTKDLKISDVIDALDRDLGPHFFPTREDGTDPRICPACGDGRLGLRLGRHGSFIGCSNYPGCSYTRRLGIDGAEGEAETLKEGMRVLGQHPETGEDITVKRGPYGLYVQQGEAEEGSKKKPRRASLPRGVDGETILLDQALGLLSLPRLVGIHPETGEPIEANLGRFGPYVKMGGIYGNLDKDDDVLTVGLNRAVDVLAKKMASIRTLGTHPKDKEPVVVRKGRFGPYVQHGQVVANVPREIEMDDVTLDDALGWLAEKGKPLKAKGGRKVAAKSSGKKAASADGNEAQPLKKATAKKTTRAAGAGKAAAKKSGTRSATAKTAKAER
(1149) DNA topoisomerase 1 [Xanthobacter autotrophicus Py2]
1
MQVVIVESPAKAKTINKYLGPGYEVIASYGHVRDLPSKDGSVDPDADFRMLWEVDPKAQKRLNEIATAVKGADGLILATDPDREGEAISWHVLEVLKQKKALKDQKVERVVFNAITKQAVLDAMKAPRAIDVALVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIETFVQKEYWSILARLATPRAEEFEARLTGADGKKITRLSVGTAEEAKAFRAALEAADFRVRSVEAKPMRRHPQPPFTTSTLQQEASRKLGLAPARTMQIAQRLYEGVDVGGETVGLITYMRTDGVDMAPEAVAATRSAIGKQFGPKYLPGVPRKYTTKAKNAQEAHEAIRPTDPSRHPREVARHLDGEQAKLYELIWIRTVASQMESAELERTTADIEAKAGGRTLDLTATGTVVKFDGFLTLYREGKDDEDDDEESRRLPAMSANEKLNRRDILTTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLAVLRDREYVKLEKKRLVPEDKGRLVTAFLESFFKRYVEYDFTADLEEKLDEVSAAELDWKEVLRAFWQDFHTAVEATKDLRVSQVLDALDEMLTAHIFPPTQDGSDPRLCPTCGNGRLSLKMGKFGAFIGCSNYPECRHTRPLTGDGAPEGDGKRELGIDPESGEDVTIRAGRFGTYLQLGEGKDGEKPKRSSLPKGLAPADVDLETALKLLALPREVGKHPEDGEPILAGIGRYGPYVQHGRTYANIEDGDDILAIGLNRAVVLIAEKQSKGRGGRGAATPGRTLGDHPTLGGPVTVRPGRFGPYVNHGKVNATLPKSVDPEALTLAEAVTLIDAKAALSPSKAKAPRKAATKAAASGEDAPAKAATKTAAKKPAAKSAAKKTATKQPAAKKTTKTASKGPKAAE
(140) DNA topoisomerase [Methylobacterium sp. 4-46]
3
MFFFEKPSAMRELQRFFRAPTTVCIAAEGHLLAAQEPAEIRPAWKAWRFEDLPIAVDEIPLCCGQSRSGASHAARIAAIRRALDGVERVIIATDPGREGSMIAWEVLEHLGYRGRVDRLRLGALDEVSIRRAFAALGRDPDSGERDYAAYQEALCRRYEDWHLGLNGTRAVSLRLRPAAFREPWRFGGVQTPTLALLADLERRIRDFVPREFFRIALPVATVSGAELTLWHAPKERIFAREEAEAIAAAARGWAGPLAVAERDVRRPPPRLFSKDTLARRCAKSFGFDPQRTASLAQDLYDRGFLSYPRTESEHLPESQSGDAPAVLAALGASLPDLAGLVPAPGAVVLRRGPRGHYVKDPGEHHAIVPLRKVPRPGEVGPEAWRLWELVAKAFLAAHLPDGIDARTTVSAEVATALGPKRFAVTGSVVRAPGWRAVYGAEAEDEEPVPGKAKREDEPSAGRLPPVAPGEAARAGEARVEGAMTEPPRRITRGELPVVMGRLIDQVEDPALKRALENPANPNEPRGLGTAATRDAVLPKLEKSGYVVLGGALPADARAGAGGNAPRRRRDTPGRADRGGGGARGRDPTITVTEAGLAFIDAVRRVFPAYGDPVGRAVFEADLAEIGRAATRAEAVSRAETFRQRTRARLDALIAAVAGLERAAVEGPAAAPAGRPPSDAMVAFATALAARKNLPLPRGVARDAAVCRRFLDAHAEKREPTAPGAPRPPTPAMLRYAESLAREAGLPDLPEEARTEFAACRAFLDAHARPAPAEARERAGPRRPGAGRPRRRPARSPRARTAGTALGEPA
(167) DNA topoisomerase 1 [Methylobacterium sp. 4-46]
1
MKVVVVESPAKAKTINKYLGHDYEVLASFGHVRDLPAKDGSVDPEQDFKMLWELEERGAKRVSEIARAVKGADTLILATDPDREGEAISWHVLEALQAKRVLKDVAVERVTFNAITKDAVQTAMANPRQIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIEAFKPREYWSLVATLATAKGATFEARLVGADGKRIQRLDVGTAEEAEAFRRDLELATFAVASVESKPAKRHPQPPFTTSTLQQEASRKLGLAPAQTMRIAQRLYEGVEIGGETVGLITYMRTDGVDMAPEAIRDARRVIGAEFGDAYLPGAPRSYSVKAKNAQEAHEAVRPTDLGRLPKEVARFLEPEQAKLYELIWIRTIASQMESAELERTVVEIAAQVGPRRLDLRATGQVVRFDGFLTLYQEGKDDEEDEESRRLPPMQAGDPLRRERVAATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQVLRDREYVRLDKKRLVPEDKGRLVTGFLESFFQRYVEYDFTADLEEQLDRISNAEIDWREVLRDFWRDFSAALAGTKELRTAEVLEALNQLLGPHIFPPRADGANPRACPNCAGGTLSLKLGKFGAFVGCSNYPECKYTRQLSAAGLDGDGEGSAGEGGQPGVRVLGEDPATGLPVTLRDGRFGPFVQLGEASAEKGAEKPKRSSLPRGLTPADVTLETALKLLALPREVARHPESGEPILVNLGRFGPYVQHGKTYANLGKDDDLLEIGANRAIDLIVAKEQGGGRPAADPGRVLGNDPEGRAVTVKAGRYGPYVTDGEVNATLPKGADKEALTLEEALRLIVARREAGGGTKKKTSGRARAARKTEAKPAAKAKAEKAAKPAAAGKSASAGKSASAAKSATAPEKAPARKKAAAAE
(1512) DNA topoisomerase 1 [Methylobacterium radiotolerans JCM 2831]
1
MKVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDGSVDPEQDFRMVWELADRGASRVSEIAKAVKGADKLILATDPDREGEAISWHVLEALTARKALKGIPVERVTFNAITKASVEQAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEARLVGADGKRIQRLDVGTGEEAAAFRRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDARRVIGKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIWTRTMASQMESAELERTTVDVTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLEEQLDRVSNAEIDWRAVLRDFWRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGSNPRTCPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSATGIDGDGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFLQLGEASTEKGAEKPKRSSLPKGLSPSDVDLNKALALLALPREVARHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRLAADPGRPLGKDEASGRDLVVKAGKYGPYVTDGEVNATLPKTMSAEALTLDEAIALVNAKRAAGGGKPAKRGAARKSSARAASGDKPAAKKTATKKPAAKKAATKKSSSG
(300) DNA topoisomerase 1 [Rhodospirillum centenum SW]
1
MPGHNVVIVESPAKAKTINKYLGQDFTVLASYGHVRDLPPRDGSVRPDEDFEMDWELGDRSKRHIDEIARAVRGADRVYLATDPDREGEAIAWHMKEVLGERRLLGKVDVKRITFNEITKSAVQTALAQPRDVNRELVDAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLVCEREAEIEVFRPQEYWTIEADFRTQEGQTFTARLSQLDGKRLEKFTLGTQGDADAAVARIRPMTFRVGRIERKEVRRNPFPPFTTSTLQQEASRKLGFGATKTMRTAQRLYEGVDIGGETVGLITYMRTDGVALSQEAIDAARRLIDESWGRSYVPEKPRIYKAAAKNAQEAHEAIRPTDLFRRPEHVARYLEKDELALYELIWKRTLASQMASAVLDQVTVDIISKGAEAVFRATGSVIRFDGFLKVYQEDKDDADEDEDHRRLPPMRDGDDLARGEIRPNQHFTQPPPRYSEASLVKKLEELGIGRPSTYASILQVLQDREYVRLEKRRFIPEDRGRLVTAFLESFFPRYVEYTFTADLEGKLDDISGGRIDWKQVLREFWRQFSAAVEDTRDLTITQVLTALDELLGPHFFPRRLGPDGQEVDARVCPTCGTGRLSLKLGKSGGFIGCSNYPECRYTRPLSVAGEGGEAESGDRMLGNDPETSLPVWVKTGRFGAYVQLGNGDGKEEKPKRASLPRGMLPATMDLDTALRLLALPRSLGTHPESGLEIVAGIGRYGPYLKHGASYKNLTAEDDVLTIGLNRAVVVLGDAPAKKAVAGRELGAHPKDGKPVKVGSGRFGPYVQHNKLFASIPKSMSADTVTLAEALELLAAKAAKDGAKKGPAKAEGGEEAAATPAKKTTAKKAPAKKAPAKKTGAAKAESAGTDAEAETAEKPARRTAAKTTKAPAKASAAKASGTKAATRKAAAGD
(1832) DNA topoisomerase 1 [Gluconobacter oxydans 621H]
1
MTDVVVVESPAKAKTINKYLGSGYTVLASFGHVRDLPPKDGSVRPDENFAMSWQTDERGAKQISAITKALKGAKNLYLATDPDREGEAISWHVRSVLEEKKLLKNVDVHRVTFNEITKSAVTAAMAAPRELDRPLIDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFRPKEYWTVTGGFTTPGKAAFQARLTHLKSEKLDQFDLNNEQLAFGARDTVLGGQFTVRSVERKRTKRNPPPPFTTSTLQQEASRKLGMSAQTTMRTAQQLYEGVDLRGETTGLITYMRTDGVTMAKEAIGSIRGHIGKAFGDEYVPDYPRSYSTKAKNAQEAHEAIRPTDVFLTPQQVAHALTPEQKKLYELIWKRSVASQMQSAELDQVAVTLADASGQTLLRATGSTIAFDGFLKLYIEGRDDTKAEDEDGKLLPPMKEGDRLTTGAVEAEQHFTQPPPRYSEASLVKKMEEIGIGRPSTYASILGVLRDRNYVRLDARRFVPEDRGRLVTAFLTSFFERYVDTGFTASLEEQLDDISGGRADWHDVMAAFWHDFSAAVAQTKDLKISDVIDALDEDLGPHFFPPRPDGADPRVCTSCGTGRLGLRLGKFGAFIGCSNYPTCQFTRRLVAEEGDTEGLNDGPKVLGQDPETGEDVTIRRGPYGLYIQRGEPNPEDKKAKPKRTTIPKGLDGNTMTLEQALGLLSLPRLVGLHPETGEKIEAGLGRFGPYVKMGAIYGTLDKDDDVLTVGLNRAVDALAKKLASIRNLGPHPKDGEPVMIRKGRFGPYAQHGQLIANLPKGQDMDEVTLDEAVALLAEKGKPLKGGAKKTSAKKAAPKAAKAKKNVAAAEGDETAPKKVTKRSPAKSATKTKTTTPRKRKTVSDTSSEG
(498) DNA topoisomerase 1 [Acidiphilium multivorum AIU301]
1
MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGDRQVAAIAKALKGADTLYLATDPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEVTKSAVQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICEREAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVERGAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVGLITYMRTDGVQMAREAITAARQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFTLTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTVELADAAGTTLRATGSILAFDGFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEELGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEEKLDEVSDGRLDWRSVMRDFWADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDPRVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEGGEDEGDQLRDGMKLLGENAEGIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGVHPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHPKDGESVTARKGRFGPYVQHGKTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAKPAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPKAAAAKAKPAARKTARSGG
(70) DNA topoisomerase 1 [Methylobacterium nodulans ORS 2060]
1
MKVVVVESPAKAKTINKYLGHGYEVLASFGHVRDLPAKDGSVDPEQDFKMLWELEDRGAKRVSEIARAVKGADKLILATDPDREGEAISWHVLEALQAKRVLKDVSVERVTFNAITKDAVQTAMAQPRQIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIEAFRPREFWSLVATLATARGAVFDARLVGADGKRIQRLDIGTAEEAEAFRRDLELATFTVGNVEAKPARRHPQPPFTTSTLQQEASRKLGLAPAQTMRIAQRLYEGVEIGGETVGLITYMRTDGVDMAPEAIQDARRVIGAEFGDAYVPAAPRSYSVKAKNAQEAHEAVRPTDLGRLPKEVARFLEPEQARLYELIWIRTVASQMESAELERTTVDIAAQVGPRRLDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPSMAAGEALRRERIAATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQVLRDREYVRLDKKRLVPEDKGRLVTGFLESFFRRYVEYDFTADLEEQLDRISNAEIDWRAVLRDFWRDFSAAIAGTKELRTAEVLEALNQLLGPHIFPPRADGANPRACPNCASGTLSLKLGKFGAFVGCSNYPECKYTRQLSAAGVEGEGDGSSGEGGQPGQRVLGEDPATGLPVTLREGRFGPFVQLGEASAEKGAEKPKRSSLPRGLSPAEVSLETALKLLALPREVARHPETGEPILVNLGRFGPYVQHGKTYANLGKGDDLLEIGANRAIDLIVAKEQGGGRPAADPGRVLGNDPESGRAVTVKAGRYGPYVTDGEVNATLPKGADRDAITLDEALRLIAARREAGGGTKKKATTRTRKSETAAKPAGKATKKAPTKASAAKKKAAAE
(1787) DNA topoisomerase [Methylobacterium nodulans ORS 2060]
3
MARASADRTLFFFEKPSAMRQLQRFFKAPTTICVSAEGHLLAAQEPAAIRPAWKAWRFDDLPIALDEIPVAYARNRSGASHAGRIEAIRGALQGVDRVIIATDPGREGSMIAWEVLEHLGYRGRVERLRLGALDEVSIRRAFAALAREPDSGERDYAAYLEALCRRYEDWHLGLNGTRAVSLRLRPPAFREPWRFGGVQTPTLAILADLERRIRDFVPRDFFKVAMPVETETGAALTLWHAPKERIFDRAEADAIREAAAGWSGPLSVVQKDVRRPPPRLFSKDTLARRCAKRFGWDPQRTAATAQDLYDSGFLSYPRTESEHLPESQSGDAAAILAAIAGCLDDVAELVPAGEAIVVRRGPRGHYVKDPGEHHAIVPLRKVPRRGELGPEAWRLWELVAKSYLAAHLPDGIDARTTVAAEVATPPGPKRFAVTGSVVRAPGWRAVYGSEAEDEDPVPGKARRDDEPTTGRLPPLRDGAAARATDATVETAVTEPPRRITRGELPVVMGRLIDQVEDPVLRRALENPANPNEPRGLGTAATRDAVLPKLEKSHYVVLAKGKDPAITVTEAGLAFIDAVRRVFPAYGDPVGRAVFEADLAEIGRAPSRAEAVRRAEEFRQRTRARLDALIAAVAGSERLAVAAPSPDGAGRPPTPAMVAFATALAARKGLRLPRGLKQDAAICRRFLDAHAEQREAAAPGAPRPPTPAMRRYAEALARENGLDKLPDDAATDFSACRRFLDAHAAPRPDAPAKPSPRKPAPRRRTRPPAGADRHADTSN
(798) DNA topoisomerase 1 [Methylobacterium populi BJ001]
1
MKVVVVESPAKAKTINKYLGRDYEVLASFGHIRDLPAKDGSVDPEADFAMVWELEDRGSKRVSEIARAIKGAEKLILATDPDREGEAISWHVIEALSARKALKGIPVERVTFNAITKASVDAAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWSIVATLATEAGGVFEARLVGADGKRIQRLDVGNAEEAAAFKRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQKLYEGVDVGGETVGIITYMRTDGVDMAPEAISDARRVIGREFGDDYVPGAPRKYSVKAKNAQEAHEAVRPTDMGRLPKQVARYLEPEQAKLYELIWTRTIASQMESAELERTTVEVTASVGPRRIDLRATGQVVKFDGFLALYQEGKDDEEDEDSKRLPAMAAGDPLKRERIASTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFKRYVEYDFTASLEEQLDRVSNAEIDWRSVLRDFWRDFSAAIGGTKELRVAEVLEALNGLLGPHIFPEKADGGDPRACPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSASGVEGEGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFVQLGEASSEKGAEKPKRSSLPKGTSPGSVTLEIALRLLSLPREVAKHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRPSSDPGRALGPHPDGAALVVKAGKYGPYVSDGSVNATLPKTMAAESLTLEQAIELINAKRASGGGKKPVRKTATRARTATKAADGAEAKKPAVRKTASKTASKSTTKAAAKPAAAKKAAAKTKAS
(1752) DNA topoisomerase 1 [Ketogulonicigenium vulgare WSH-001]
1
MPVVVVESPAKAKTINKYLGSDYQVLASYGHVRDLPPKDGSVDTDEDFAMTWEVDANSKKHIKAIADALKADPNLILATDPDREGEAISWHLVEALTDRKAIKKDTPVSRVVFNAITKSAVTEAMQNPRQVDAPLVEAYLARRALDYLVGFKLSPVLWRKLPGAKSAGRVQSVCLRVIVDREVEIEAFRAQEYWTVAAEIETPRGQIFTARLVTLGGKKLDKFDLGNQVAAEMAVQAVTSRALSVQGVEAKPAQRHPSAPFMTSTLQQEASRKFGMGAKATMSAAQRLYEAGLITYMRTDGIDMAPEAVMAARDAIRDKFGADYLPASPRMYKNKAKNAQEAHECIRPTDMTRGVEQQKIVDADQRKLYDLIYKRTIASQMAAARLERTTVDIGAADGQVGLRATGQVVLFDGFLAIYEEGRDDSTDEDEGRLPQMMQGEALKKLAVTPDQHFTQPPPRYTEATLVKRMEELGIGRPSTYASIVTTIQDRGYVQKDKNRLIPQDKGRLVTAFLENYFPRYVEYDFTAGLEDQLDKVSAGDADYKDVLRQFWRDFSAALNETSELRITDVLEKLNEVLSPIMFPPKPDGSDPRACPNCGNGHLSMRTARSGGAFIGCSNYPECRFTRPFGPPELAEGAIGPDGRLLGHDEGDPITLRDGRFGPYVQRGEATEEVPKPPRASLPKTWSPDEVTLERAVSLLNLPRPVGPHPEDGVLIEAGLGRFGPFIKHGSTYANLKSIDEVFEIGMNHAVELLAQKLAGGRGRTAVAKPLKELGDHPDGGAITVMPGRYGPYVKWEKVNATIPKDIEPEALTIEQALELITAKAGKKPAKKPAKKAATAKAATTKAKAAPKAKTTKAKAASADPAKPKRKTAKAAPDVVEDEA
(36) DNA topoisomerase 1 [Ruegeria sp. TM1040]
1
MPVVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPAKNGSVDPEDDFAMTWEVGNDSKKHVRAIAEALKDDNALILATDPDREGEAISWHLQEALTKRRSIKKDTDVKRVTFNAITKDAVAEAMKNPRDVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVCLRLIVEREMEIEAFNPQEYWSVRANLATPRGQSFEARLTVLGGEKLDKFSLANSTAAELAVQAVSSRKMSVLSVEAKPAARNPSAPFMTSTLQQEASRKFGMGAKQCMNAAQRLYEAGLITYMRTDGIDMAPEAVSAARDEIAKRYGQEYVPGEPRIYKNKAKNAQEAHECIRPTDMSRDAASLKVSEDDQRKLYDLIWKRTLACQMAGARLERTTVDIGSDDKQVVLRATGQVVMFDGFMRVYEEGRDDVVDEDDKRLPQIMQGEALKFAGSLAAQAEKAGKDGSVLSQDGATLALQHHTQPPPRYTEATLVKRMEELGIGRPSTYASVITTIQDREYVRKDKNRLFPEDKGRIVTIFLLNFFKRYVEYDFTAALENQLDDVSAGGKDYKELLDSFWRDFSAAISETSDLRISEVLDVLDEALAPQLYPPREDGGDPRICPKCGAGQLHLKTSRTGGFVGCGNYPECNYTRPISGEGAEGYERVLGEDDGDEIHLKSGRFGPYVQRGEATPENKKPPRSSLPKQGKDYLPGWGPNEITLEQAVTLLTLPREIGAHPEGGVVSSNLGRFGPYIMHQRPDEEKPVYVNLKETLDVFEIGMNRAVEMLAEKRANPGRGRSAAAKPLRELGEHPDDKAPVNIMDGRYGPYVKWGKVNATLPKDTEAKDVTMEMAVELLNEKAAKSGKKKAPAKKAAAKKTTAKKTTAKKAPAKKKEAKASGD
(619) DNA topoisomerase 1 [Sphingobium chlorophenolicum L-1]
1
MQLVIVESPAKAKTIEKYLGGDFHVLASYGHIRDLPAKDGSVDPDAGFAMQWENYGDKGKQLKAIADEAKKATRLILATDPDREGEAISWHVQEVLRAKKALPQKVDRVTFNAITKQAVTEAMAQPRALDEDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIESFVPQEYWSVAAEMEQGGQGFTARLVRWRGEKIERLTIGREGDAMAAKADVEAGRFTVEKVETKPVSRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQQLYEDGAITYMRTDGVQMDGSAISAARKAIAERYDGGYLPEKPRQYQTKAKNAQEAHEAIRPTEFYRDKVGSGDHARLYDLIFKRALASQMASARLERTTIDLVDGTGQHGLRATGQVVIFPGFLALYEEGRDDTEDDDSKLLPRMAEGDAPAKKKVTAEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASTLQVLKDRDYVRIEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEEELDDISGGRAQWQAVLEAFWRDFKPKTTEVMEQKPSDITAELDKFLEPMLFPPKADGSNPRACPMCGDGQLSLRGGRFGAFIACSNYPECKYTRKFGQPGGKDGAEDSGPEVLGKHPETGQDIVRKSGRFGPYIEMGEGKEAKRGSIPKDLPDGEMTLDWAVKLLSLPREIGLHPETGKPIVANIGRFGPYLLHDGKYGRLSSTAEIFEVGMNSAVAKLADAANRGGRGASSREPLKVLGKHPRTEAEIKLMAGRYGPYVTDGTTNATLPKTIEQDALTLEEAAQLIDARAAAAPAKKGKKAPAKKAAAKKPAAKKAPAKKKVAAE
(680) DNA topoisomerase 1 [Phenylobacterium zucineum HLK1]
1
MNVVIVESPAKAKTINKYLGSDYKVLASYGHVRDLPAKDGSVRPDEDFAMSWDVDAKAAKRLSEIAEAAKGADRVILATDPDREGEAISWHVLEVLQKKRALKDAKVQRVVFNAITKSAVTEAMANPRELDMELVEAYLARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDRELEIERFRTQEYWTVEAEVAAGGDPFTARLVKHEGKRLSKFDLGNEASAFAARDAVKAATFKVAAVERKPGRRSPPPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVQTAPEALDEARAVIGGLYGKDYVPEKPRFYSTKAKNAQEAHEAIRPTSLGRNPGKLRLEGDLGRLYELIWKRMIASQMESARIERTTIDLESADGRTGLRATGQVVTFPGYLAVYEEGRDDPEDEEGGRLPQVAEGAQATVRQAKADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASILERLRDRSYVRMEKQRFVPEDQGRIVTIFLEEFFGKYVEYDFTADLEDQLDQVSAGDLDWKVLLKNFWADFNAKVGELGQIGTREVIDALDESLASTLFPPMADGSDPRVCPRCGSGRLSLKPSRTGAFIGCSNYPECRFTRPFGPPDAEGAEASGDRDLGTDPQTGETVWLKAGRFGPYVQLGEGEKPKRSSLPKGWSVADMDLEKALRLLRLPREIGPHPEDGKPILAGIGRYGPFVQHNGTYANLPSVDEVFEVGLNRAVDLIATKRAGGKRGGEAEALKDLGAHPADGQPVRVLAGRYGPYVKHGSTNATIPKGADPKALTLDEAVKLLAEREAKGGGKKKPARKAKAEPKAKKAPAKKAPAKKAAAKTPAKATPAGDIDDDESPF
(1109) DNA topoisomerase III [Azospirillum lipoferum 4B]
3
MATLIITEKSSQAKDLRAALGDRYGRILPAEGHLLRLAEPDEVDPAWKRWSPTLLKPDGLYPTRPDQGGNKAAKLQAITAALRACDEVILATDCDREGQLIGQEILEHVGYRGKVRRALFTAQDPKTLRDAFSALKPNDSMRPLYEAAVARQQADQIYNLSLTRTATKTLLAPGTRGVIGIGRVKTPTLAIVCLRELEIRNFKPEDYFEVVATASVAEGSFQMRHAPAPKDRIKDRATAEAIARAADNHRGPLTVTVEEKRQVPPKLYDLPALQKTCGQRWGWTADRTLAVAQELYDGDGKKLITYPRAEARYLSENQIADVPAIVGALTRLRGFAHLDIARPVIRKGKSGHFCDKALEGVSHHAVIPNVNVLDDLESRLVRLTDDEKRLYALICRSYLAAVMPDYEYRQTSVTMPVPMPTPGGTKPVAFRAVGRIPLKLGWKAAFGSAESDDRSGGKPEEEAEQTLPPLTDGEPATLSDPKLEAKRTQAPPRYNEGTLVDAMQNAWRFVEEPSLRDRLKEAKGIGTPATRAEVIKGLRKQNLLGADGKWLVPTPAGLHLFETLRAAAPTLVDPGTTALWEMKLDDVVTGRADFRRVIDAIATEAERLIGALVGQRGTLLDLGMPAPKARFARRGTGGRTTGAAAGAAKPVRRRTRKAEAPVEGGAAAPKPRRVRKAKAPASAPPTSAQADNGRPAAPATAPAPPNGLRRREPTERMVAFARSLAERKGIDLPDPCLRDFDQCRSFLDQHAR
(744) DNA topoisomerase 1 [Azospirillum lipoferum 4B]
1
MPGSNVVIVESPAKAKTINKYLGDDYTVIASFGHVRDLPARDGSVRPDEDFAMEWELGDRSKRHIDEIAKAVKSADRVYLATDPDREGEAIAWHLSELLREKHLTDNRDVQRITFNEITKSAVQAAIANPRDVSRELVDAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICERESEIEVFKPQEYWSIAVGFTTPAGAGFTASLTQLDGKRLDKFGLPNREAAEAAVAKILPQSFAVSSVERKQSRRNPSPPFTTSTLQQEASRKLGFGATRTMRTAQKLYEGVDIGGETVGLITYMRTDGVSLSQEAIDGARSLIGSQYGERYVPAQPRVYKTAAKNAQEAHEAIRPTDLQRRPDSVAGYLESDELRLYELIWKRTLASQMESAVLDQVAVDIANPSKDVVLRATGSIVVFDGFLKVYQEDRDDAAEDDQQERRLPAMDQGDALARGDIAQDQHFTQPPPRYSEASLVKKLEELGIGRPSTYASILQVLQDRNYVRLDKRRFIPEDRGRLVTAFLENFFHRYVEYNFTAELENQLDEISDGKIDWKTVLRDFWTAFDVAVNGTKDLTITQVLTTLDNELGAHFFPAATADGHDPRVCPVCREGRLGLKLGKMGAFIGCSRYPECRYTRPLAVANDENGEAQEGPRELGNDPETGLPVTVRRGPYGAYIQLGPAPTVAAPPEEPAVEEPAADGKKPKAKKKKKDEAPKPKRVSLPKGMAAADVDLDTALKLLALPRTIGNHPETGEEISAGIGRFGPYLKHGSVYKSLTPDDDVLTIGINRAVDLLAGAAKKASAPAKTLGDHPKTGKPITMGSGRFGPYVKHASVYASIPKGTEPDSVTLEQALELIDAKVAKDAAKKGKAPKDAEPAKAEGAEAEKPAKAKAAAKKPAAKKATKAKAAKDAPAEAAAPKKKTAKAS
(68) DNA topoisomerase 1 [Rhodospirillum rubrum F11]
1
MHVVVVESPAKAKTINKYLGKDYVVLASYGHIRDLPPKDGSVRPDEGFAMDWEIDAKSEKHVKDITQALKSADGLLLATDPDREGEAISWHVRDVLEKRKALVGKQVQRITFNAITRSAVEEALRNPRDLDTPLVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREQEVERFVSREYWTVDAILASPQGQIFRARLSQLDGQKLDKFGLPDETTALAALERIKAATLRVESVERKQARRNPAAPFTTSTIQQEASRKLYFSARQTMQVAQKLYEGVDLGGETVGLITYMRTDGVSIAPEAVFATRDLIGAEFGAAYLPEQPRVYKTKAKNAQEAHEAIRPTDVARTPQSVAPYLTAEQRKLYELVWKRTVASQMASAILDQVAVDIADPEAKVVLHATGSVIQFDGFLKVYREDFDDRPESSPDGAGEDENRLLPPLREGDGVKREDVKADQHFTQPPPRYTEASLVKRMEELGIGRPSTYASILSVLQDREYVRLDARRFIPEDRGRLVTAFLENFFSRYVQYSFTADLENQLDEISDGKLGWKTVLERFWMDFKAAIEGTATLRVSEVLDALDKELGPHLFPQAEDGHDPRVCPVCSAGRLGLRIGKFGAFVGCSNYPDCKFTRPLVTKEGEGGDGAALAEDGTKPLGKDPVSGEDVTLRKGPYGLYVQKGEAAPVEKGKKAVKPPRVSIPKDMDAATIDLDIALKLLSLPRPVGDHPETGTMISAGIGRFGPYIKHGDIYKSLPKDDDVLTIGLNRAVSLLAEAGKGGRARQPARSLGDHPADTKPVTIHDGRFGPYVQHGGVRATIPRTADPATYTLAEAVELIAAKAAKDGDGKKAPAKKAATKAPVKKAAAEKKAPAKTATKKAAPKKAADSAEDAPAKAPRKSKAKPASADPD
(1771) DNA topoisomerase 1 [Micavibrio aeruginosavorus ARL-13]
1
MSASNLVIVESPSKAKTINKYLGPDYEVLASYGHVRDLPPKDGSVDPENGFAMLWELGDRAAKPVNDIRRAVKKAKALYLATDPDREGEAISWHVQELLKDEKLLEGKQVFRVTFNEITKKAVQEAFKNARDLDAPLVEAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRLICERESEIEKFRADEYWTIEARLHNRDGAPFTARLTHLSGNKLDKLDIGSEAQATAAANRIRGKNLVVQNVEKKQVRRFPPAPFITSTLQQEASRKLGFGASQTMRLAQRLYEGTEINGDTVGLITYMRTDGTTLSEDAVTQCRDVIKSNYGPKYLPDAPRLYKSKAKNAQEAHEAIRPTDLSRTPDEVRMYVDDQMARLYELIWKRTMASQMENAVMDQVGADISDGTTDVVLRATGSTVAFDGFLTLYQEGQDDDETDEENRRLPVLDKGDATKLIDVAQDQHFTQPPPRYSEASLVKKMEELGIGRPSTYASILQVLQDRDYVRLDKKRFIPEDRGRLVTTFLSKFFTRYVDYDFTATLEEELDAIAAGQAHWKDALAQFWKDFSKAVGDTKNLTITEVIDNLDAELGPHFFPVVEHGKDPRICPACNEGRLSLKLGKFGAFIGCANYPDCRYTRPLVVPSADENAEGGEAGGESGLAAQLANAPKILGHDPVTGRAVSLRRGPYGPYVQIDPPEAPPAPAVEEKAPEVEDGTAKKGKGKAKKKKETAEKPKRQGVPKGLKLEDIDLAAALKLLELPREVGLHPETKEMIKAGIGRFGPFLVHQGSYTSIPKGDDVLTIGINRAVDLIAAKAERAANGGGRRGGWGKKKAKADGDDAAPKKTAAKKKAPDKKAAAKKPAAKKTAAKKPAAKKTATKKPAAKE
(1672) DNA topoisomerase 1 [Caulobacter sp. K31]
1
MIVVVVESPAKAKTINKYLGSGYTVLASYGHIRDLPSKDGSVEPDNDFAMHWEADAKGAKRIGDIVDAMKGADGVILATDPDREGEAISWHVLEVLQKKKAIKDKSVQRVTFNAITKTSVLEAMAHPRDIDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVCLRLIVDRELEIERFKTQEYWSVEADVTAGAEPFVARLVKHENKKLTKFDLNNESSALAAKAAVEKAVFKVAAVEKKPGKRSPAPPFTTSTLQQEASRKLGFSAQRTMQAAQKLYEGIDIGGETVGLITYMRTDGVSVEPEGIAEARSVIGSVYGETYVPETPRYYKAKAKNAQEAHEAIRPTSLKRNPGSLRLESDLGRLYELIWKRMIASQMESARIERTTVDLESADGQTGMRATGQVVLFPGYLAVYEEGRDDEGDEDSARLPMIEEGAAAKVLDARADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASVLTVLRDREYVRMDKQRFIPEDKGRLVTAFLEQFFRRYVEYDFTAALEEQLDLVSDGKLDWKQFLRDFWKDFHAAVGEIAELRTTNVLDALNESLGPHIFPDKGDGSDPRLCPTCGTGQLSLKVGKFGAFIGCSNYPECRFTRQLATAEGEGEAEAADKELGINPATGRAVWLKNGRFGPYVEEPAAEGSGDKPKRSSLPKGWTPAGLDLEKALRLLALPREVGMHPDDGKKITAGLGRFGPFVLHEGTYANLENPEEVFDIGLNRAVALLADKRAGGGRPQRGQAAALADLGVHPEDGKPVKVLSGRFGPYIKHGDTNANVPKGADPAALTLAEAVVLLADRVAKGGGKKPAKKAAAKKAPAKAKAAAATDGGAPAKKAPAKKAPAKATGAKKTAAKKPAAKKAKAEA
(741) DNA topoisomerase 1 [Candidatus Pelagibacter sp. IMCC9063]
1
MNLVIVESPAKAKTINKYLGSNYIVLASFGHVRDLPSKNGSVDTENNFNMVWEIDTASKKHIKEIADAAEDCEKIILATDPDREGEAIAWHVRHILEDKNLLKGKKVERVVFNEITKKAVVYGVENPRDLNIELVNAYLARRALDYLVGFNISPILWTKLPGSKSAGRVQSVALKIIVEREYEIELFKPEEFWTLNAVFKNSQNKEINSKLNIYDSKKVEKFSFKNKKAAENAVAEINKNEFKVKSIESKPFKRNPYAPFRTSTMQQDASRKLGFGASRTMQVAQRLYQGIDIEGETVGLITYMRTDGTDISLDAVADCRTFIKNEIGEKYLPSEARNYSGKKAKNAQEAHEAIRPTDITRTPNSLKSKLDKDQMRLYELIWNRTVSSQMESAEFERTAIDFTNQSSSMIFRANGSIQKFDGFLKLYQEVKDEDDKEKEDSDEDNILPEVVKDEILKIDKVLNEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASIISVLSTRNYVEVLNKKFTPTDRGKLITSFLNQLFTRYVDYNFTAGLEESLDDITTGKADWIEVLAKFWKEFNQNVLEVKELRTRAILDMMNESLGEIIFDKDNEGKIKRSCECGGELSLKTGRFGAFIGCSKYPDCKFTRPMSRIKAAEQDYLAEPKEIGKTEDDKNIVLKKGRFGPYLQVGNDEKEMKNVSIPKGISLDDIDLDKARFLASLPKVLGQYPENSMDITLNNGRYGPYVKCDKKSATLEAPEDIFSIGLNKAITMIADAKPGRRSSNEIKLIGEHPEDKKPVKVMKGSYGPYIKYKTINATIPDDKDPESVTMEEALDLIEKRLEYDSTKKGKKIKKKTAKKRKPKKKADKNKDEEK
(892) DNA topoisomerase [Bordetella avium 197N]
5
MNKTLIIAEKPSVALDISRALGGFAREGDFFESESYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSSERLKLLVRLAKRKDVDTIINACDAGREGELIFRYIIQYAGVKKPIKRLWLQSMTQAAIREAFANLRDDVQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVAERESRIRSFVPRDYWEVHATFVAAAGLYEGRWIDPDFKKDERDPEKRESRLWSAAAAQSVVAACREQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLSLAQTLYERHKALTYPRTDSRYLPEDYVNTVRQTMRALSEGGSNAVGGLARHAGTVVSNDWVKLHRRIFDNKKVSDHFAIIPTLQIPHDLSEAEGKIYDLVLKRFLAVFFPAAEYRLTTRLTEVQGHRFKTEGKVLVAPGWLAVYGKEAQGEDANLVPVADGEKVRTEDVRAEALSTKPPARYNEATLLSAMEGAGKLVDDGELREAMSERGLGTPATRAAIIEGLLNESYLRRDGRDLVPTAKARQLMTLLAGLDVAELTSPELTGEWEHKLKQIEQGGLDREAFMREIAQMTQVIVKRAKEYERDTVPGDYATLKTPCPHCGGVVKENYRRYACTQCEFSISKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISDEYKLEFDFGQSDEEDDTPVDFSGHTPVGACPKCHSQVFEHGMSYVCEKSVGPAKSCDFRSGKVILQQEISREQMSKLLSEGRTDLLDGFVSSRTNRKFKAFLVRQPDGKIGFEFEPRGDKPARRAAAKKAPAKTATKTAAKTAVKKAASKTTTKTASKTATKTATKTAAKKAAAKKTAA
(1723) DNA topoisomerase [Pusillimonas sp. T7-7]
5
MTKTLIIAEKPSVALDISRALGGFTREGDYFESEQYVLASSVGHLLSLVAPNDPVRGKWSFTHLPVIPPQFELGPTDKRSSERLKLLVKLLKRKDVDAVINACDAGREGELIFRYIVQYSGVKKPVKRLWLRSMTQAAIREAFANLRDDDTMKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNEREERIRKFVSRDYWEVHATFVAAAGFYTGRWFDPKFVKDERDPEQRDSRLWSNTAAQTIVMACRGQSGKVTEESKPSTQMSPALFDLTSLQREANSRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYISTVQQTMEALSEGGSSAVANIRPFAETICKQKWVKPNRRIFDNKKVSDHFAIIPTLQVPRELSEAEGKIYDLITRRFLAVFFPAAEFRITTRITEVSGHHFKTEGKVLIAPGWLAIYGREAQGDDTTLIAVSEGETVKTDEVEAKGLATKPPAHFNEATLLSAMEGAGKLVDDEALREAMSERGLGTPATRAAIIEGLLNEGYLRREGRDLIPSAKARQLMTLLSGLGVNELTSPELTGEWEHRLKQIEQRELDRDAFMREIAQMTQVIVKRAKEYERDTVPGDYATLSTPCPKCGGVVKENYRRYACTNCDFSIGKHPGGRTFEIDEVEELLTKRELGPLPGFISKMGRPFAALLRITDEYKLEFDFGQKDDEDTEPVDFSGHTPVGECPKCHHKVYEHGMNYVCEKSVGPDKTCDFRTGKMILQQEISAGQVSKLLSEGKTDLLEGFVSSRTNRKFKAYLVKQPNGKIGFEFEPRPVKAGAKTAAKKAASKTASKTAAKTATKTAAKKAAAKKAATKAPAKKAAKKTAVKKAAVKKAVKAAPVTASGDDDPPF
(723) DNA topoisomerase [Achromobacter xylosoxidans A8]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESERYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPEFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIIQYAGVKKPIQRLWLQSMTQAAIREAFANLRDDSQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVAEREERIRRFVPRDYWEVRATFVAAAGLYEGRWIDPQFKKDDRDPEKRESRLWSEAAAQSVVAACREQPGNVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYIATVQETMRALAKGGSNAVGGLSRHAETVVGNQWVKPNRRIFDNKKVSDHFAIIPTLQIPHDLSEAEAKLYDLVLKRFLAVFFPAAEYRVTTRMTEVQGHRFRTDGKVLVSPGWLAVYGKEAQGEDANLVPVADGETVRTEDVEAVGLSTKPPARFNEGTLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEVYLRREGRDLVPTAKARQLMTLLSGLDVTELTSPELTGEWEHKLKQIEQGGLGREAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGAVVKENYRRFACTACDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISDEFKLEFDFGQSDEDDNEAVDFSGHTPVGSCPKCQSRVFEHGMSYVCEKSVGPEKSCDFRSGKVILQQEISREQMEKLLTNGRTDLLDGFVSSRTNRKFKAFLVRQPDGKIGFEFEPRPEKPGRAPAKTAAKTATKTAAKKAPAKKAAVKKTATKTATKTAVKKAVKKAAPKKTAA
(834) DNA topoisomerase [Achromobacter xylosoxidans A8]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDASADDAGRCLQQPIAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRTQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTVADLSCGQQKLVATGKQVVVKGWRLVLAEPEREGSADEDGDAPRSQVLPALRDGMACQVAGADIKALKTMPPKPYTQGELVKAMKGVARFVTDPRLKQKLKDTTGIGTEATRANIISGLIARGYIVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPACKGTLPVATGTSRRGASRPRRTSGGGCKGA
(172) DNA topoisomerase [Taylorella equigenitalis MCE9]
5
MSKTLVIAEKPSVATDLSKALGTFKKETGFYENDHYVISSSVGHLLTLFNPDDAVRGKWSFTNLPAIPSKKFEIQPIDKKSKERLTLLVKLIKRADIELIINACDAGREGELIFRYIMQYAKVKKPIKRLWLQSMTKQAIQEAFENLRSDESMKPLEDSARSRAEADWLIGINGTRAMTAFNSKGGGFNKTPIGRVQTPTLAIVYDRDQKIRAYEPKDYWEVVATFVASAGVYEGKWFDPEFKKNPKDPDARESRLWDANTAKTIVLACKGKEGTVTEETKENTQNSPILFDLTTLQREANSKFGYSAKTTLALAQALYEKHKLITYPRTDSRYLPEDYLNTVKENIKSMSSDSSSLHTGHKEFAQKIISNKWVKSNKRIFNNSKVSDHFAIIPTSNSTATLSEAEFKVYDLICKRFMAVFYPPAIYNVTTRITEVISYKFKTEGKILVSPGWLEIYGREEMDETLPPIKANETVLTESIESIQNKTKPPAHFNEATLLSAMEGAGKLVDSDDLREAMSERGLGTPATRASIIEGLISEQYLRREGKDLITTIKTKQLMTLLHGLSINELTSPELTGEWEYKLRQIEEGNLDRDKFMQEIAKNTQIIVKRAKEYEHDTVPGDYATLETPCPVCGGVIKENYRRYACTDCDFSITKNPGSRPFETAEVEEFLTNRSIGPLSGFISKMGRPFAAILKLTDDNKLEFDFGNDNAQEKEDIDLTALEPVGKCPKCSSNVYDTGLNYACEKQIKDKSCDFKSGKVILQQEIPLEQMQKLLSNGRTDLLEKFISNRTKRAFKAYLVLEKNGNVGFEFEKKSSTGRKSSKK
(559) DNA topoisomerase III [Comamonas testosteroni CNB-2]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFEKHDDYFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPRFDLKPVDKTKTRLNAVVKQAKRKDVTELINACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFNNLRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQAGQYLGKWFNPQWKKSDDAEAKADRLWNKADAEAIAAAVQGKPAQVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFDMLATSGMRHLAPFAQQAINDNYIRPTKRVFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAANEVEDAKEGDKGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLEVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRYACTGANGASEGCGFSFTKSPAGRTFETAEAEQLLRERRIGPLEGFRSKAGWPFVAEVAIVRDEENSNFKLEFDFGDDKDSEDTGEIVDFAHQQSLGPCPKCGSPVFEHGANYVCSKAVPTLAQTTPSCDFKSGQIILQQPIEREQMSKLLQTGKTDLLEKFVSNRTRRNFKAFLVWDGAAGKVNFEFEQREGKYPARKTAGAAAAKTTTAAAKKTGTAAKKTAAKTATKTAAVKKPRTVSATLKPSADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFELAGIVGKHVS
(313) DNA topoisomerase 1 [Rickettsia akari str. Hartford]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKASKYVDAIVKDAKKADSVYLATDPDREGESISWHVAEVIKEKNKVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDKIERFKSEEYWDISIKIQSSNNELFTAQLTHVNDQKLEKFSIINAKDAKDLTEKLKSQKFHVDKIEKKQQKRAPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDTSYGNKYLPSSPRIYKSKVKNAQEAHEAIRPTNITYTPDNLKELLEKDYYKLYELIWKRTVACQMENVIMDLVVASLASENKEYLAKATGSTITFDGFYKIYRESVDDEDEEENKMLPPLKEQESLKTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFRKYVEYDFTAGLENELDEIAAGKLEWKAALNNFWSGFNNNIKSVNEQKITEIISYVQKALDYHLFGENKESKVCPSCKTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEAELSAIPNGNKILGTDKDGIEIYLKKGPYGPYIQHGEQEGKVKPKRSPIPAILNQNDITLEIALKLLSLPLKIGIHKDSGEEIMIGYGKFGPYIKYMSKFISIPKKYDFLNLSLDDAMKLIEDNNAKLETTQG
(465) DNA topoisomerase III [Polaromonas naphthalenivorans CJ2]
5
MKTLVIAEKPSVAQDIVRALTPTAGKFEKHDEYFESDDWVITSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKPMDKTKTRLNAIVKLTKRKDIGALVNACDAGREGELIFRLIQQYAKSKHPVRRLWLQSMTPAAIRDGFAALRSDAQMLPLADAARCRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRKFVSRDYWEIHALFSAEAGEYPGKWFDPKFKRAAANADNAEPDPELKADRLWTEREARAIADAVRGQTATVTEESKPTTQAPGLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYVPVVKQTFEMLATSGMNHLAPHAATALKGNYIKPTKRIFDNAKVSDHFAIIPTLQAPSGLSEAEQKLYDLVVRRFMAVFFPNAEYLVTTRISVSVGHSFKTEGKVLVKPGWLAIYGKEAAAEVPEAKEGDKGQSLVPVKPGERVGVEAADAKALKTRAPARYSEATLLGAMEGAGKTIDDDELREAMQEKGLGTPATRAATIEGLIAEKYMLREGRELIPTAKAFQLMTLLRGLDVQELSKAELTGEWEFKLAQMEHGKLSRETFMAEIAAMTKNLVAKAKGYSRDSVPGDYATLQARCPNCGGVIKENYRRYTCTGATGDGEGCGFSFGKTPAGRTFELAEVEQFLRDKKIGPLEGFRSKAGWPFTAEMVLKFDEETKNYKLEFDFGDDKNADTGEIVDFGDQESLGACPKCAANVYELGKNYVCEKSVPTLEQPTPSCDFKTGQVILQQPIEREQMSKLLATGKTDLLDKFVSMRTRRAFKAMLVWDAEAGKVNFEFAPSKFPPKPGAAPRAGAGTIKTPFGKTVAVKAAAAPAAKKAAVKKVAAKKSAAASDKPKAVRKAAAPGAGLKPSDALAAIIGSEQVARPQVIKKLWDYIKDQNLQDPANKRAINADAKLLPVFGKPQVTMFELAGIVGKHLS
(673) DNA topoisomerase III [Acidovorax sp. JS42]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFEKHEDHFENERYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKQARRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFENLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGEYLGKWFDPKWKKSDDPEARADRVWSYHQAKDIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFGMLAGSGMRHLAPFAQQALDDGYVRPSKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLDVQELCRADLTGEWEFKLAQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRYACTGANGAGEGCGFSFTKSPAGRTFETAEAEQLLRDRRIGPLEGFRSKAGWPFVAEVTIARDEEAGNYKLEFDFGDDKNAEESGEIVDFAGQESLGACPSCGAPVYEHGSNYVCSKSVPTAQQPTPSCTFKSGKVILQQPVERAQMQKLLATGKTDLLDKFVSMRTRRAFKAFLAWDKEAGKVNFEFEQRESKYPPRKTAAAKTGAASARGTGAGAVKASKPATKAAAKKAAAKTTAAKTPRKASTAAGKAPSAQLAAVIGTEPVARPEAVKKMWDYIKAHNLQDPQDKRTIVADDKLRAVFGKDRIGMFELAGILGQHLA
(53) DNA topoisomerase [Acidovorax sp. JS42]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGYRGPIARLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDASTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRAQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETIARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPDCKGTLPVETGTSKRGASRPRKSGRKGS
(574) DNA topoisomerase [Acidovorax sp. JS42]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGYRGPIARLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDASTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRAQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETTARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIVQYGSTSLSIKVPQGPACPQCGAPTRQRTGKTGPFWSCSRYPDCKGTLPVETGTSKRGASRPRKSGRKGS
(727) DNA topoisomerase [Acidovorax sp. JS42]
4
MRVFLCEKPSQGKDIARVLGAGHRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGDQYKRWAIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYHGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYMGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAVDVLLSHAGRSFTASWIPPEGSTDAAGRCLQQPVAQQAADCIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPAVLDALLATDPSLRPLIGQLDRNQRSRAWNDGKVTAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQFSCGSQSLAAVGKQIAVTGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLKALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANTINGLIGRGYLVKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMALDTFIEKQSVWVGQLVQQYRGATLSLKLPPAPACPQCGAPMQQRTGKSGAFWSCSRYPDCKGTLPIESPTGRRSAPRKRCAASKAS
(699) DNA topoisomerase 1 [Rickettsia slovaca 13-B]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKIKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPSENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(1766) DNA topoisomerase III [Acidovorax avenae subsp. avenae ATCC 19860]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKLARRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLNKPVRRLWLQSMTPQAIRDGFGNLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRQFVSRDYWEIHAGFHAEAGEYLGKWFDPQWKKVADDPEARADRVWSFERAREIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKDTFGMLATSGMRHLAPYARQALDENYVRPSKRIFDNAKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYMVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEYAEAKALKTKPPARYSEATLLGAMESAGKQVEDEELRSAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTERMVKKAKEYDRDTIPGNYATLSTPCPNCGGVVKENYRRYACTGADGRGDGCGFSFTKSPAGRTFEPAEAEALLRERRIGPLEGFRSKAGWPFTAEVTIVRDEEAGNFKLEFDFGDDRAGEASGELVEFTDEPLGPCPICGAPVHEHGSNYVCSKAVPTAAQPTPSCTFKSGKVILQQPVEREQMAKLLATGKTDLLDKFVSMRTRRNFKAFLAWDKEAGKVNFEFEPRESKFPPRKFAGKAGAAAGAAKAGTAAAAKKAAKPAAKAAAKKSSTAAKAPRKTAAGKPPSAALAAVIGPEPVGRPEAVKKMWEYIKAHNLQDPKDKRTINADAKLREVFGKESAGMFELAGILGKHLQGDSE
(83) DNA topoisomerase 1 [Rickettsia africae ESF-5]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESIDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPATMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMDQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(1643) DNA topoisomerase 1 [Rickettsia rickettsii str. 'Sheila Smith']
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDATKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTQVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKAVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCHTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIIIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(169) DNA topoisomerase III [Acidovorax ebreus TPSY]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFEKHEDHFENERYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKQAKRKDVTELVNACDAGREGELIFRLIEQYAGGAKGTLAKPVRRLWLQSMTPQAIRDGFENLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGEYLGKWFDPKWKKSDDPEARADRVWSHHQAKDIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFGMLAGSGMRHLAPFAQQALDDGYVRPSKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLIKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLDVQELCRADLTGEWEFKLAQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRYACTGANGAGEGCGFSFTKSPAGRTFETAEAEQLLRDRRIGPLEGFRSKAGWPFVAEVTIARDEEAGNYKLEFDFGDDKNAEESGEIVDFAGQESLGACPSCGAPVYEHGSNYVCSKSVPTAQQPTPSCTFKSGKVILQQPVERAQMQKLLATGKTDLLDKFVSMRTRRAFKAFLAWDKEAGKVNFEFEQRESKYPPRKTAAAKTGAASARGTGAGAVKASKPATKAAAKKAAAKTTAAKTPRKASTAAGKAPSAQLAAVIGTEPVARPEAVKKMWDYIKAHNLQDPQDKRTIVADDKLRAVFGKDRIGMFELAGILGQHLA
(1876) DNA topoisomerase 1 [Rickettsia conorii str. Malish 7]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSHKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKAVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(383) DNA topoisomerase [Bordetella bronchiseptica RB50]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESDRYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIVQFAGVKKPIQRLWLQSMTQQAIRDAFANLRDDEQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNERENRIRSFVSRDYWEVHATFVAAAGLYEGRWIDPAFKKDERDPEKRESRLWSLAAAQSVVAACRAQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYINTVRQTMQVLAQGDSNAVGALSRHADTVLAQNWVKPNRRIFDNKKVSDHFAIIPTLQVPRDLSEAEGKLYDLVLKRFLAVFFPAAEYRVTTRLTEVQGHRFKTEGKVLVTPGWLAVYGKEAQGEDANLVPVADGETVRAEDVEAVGLATKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEAYLRRDGRDLVPTAKARQLMTLLSGLDVSELTSPELTGEWEHKLKQIEQGALDRAAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRFACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISGEYKLEFDFGQNDEEDNEAVDFSGHTSVGACPKCSARVFEHGMSYVCEKSVGPQKSCDFRSGKVILQQEISREQMEKLLTAGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRGDKPGRPGAAAKKAAGKTATKTAAKAPAKTAAKKAVKKAAPKKAATKTAARKAAKKSAA
(1307) DNA topoisomerase [Bordetella pertussis CS]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESDRYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIVQFAGVKKPIQRLWLQSMTQQAIRDAFANLRDDEQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNERENRIRSFVSRDYWEVHATFVAAAGLYEGRWIDPAFRKDERDPEKRESRLWSLAAAQSVVAACRAQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYINTVRQTMQVLAQGDSNAVGALSRHADTVLAQNWVKPNRRIFDNKKVSDHFAIIPTLQVPRDLSEAEGKLYDLVLKRFLAVFFPAAEYRVTTRLTEVQGHRFKTEGKVLVTPGWLAVYGKEAQGEDANLVPVADGETVRAEDVEAVGLATKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEAYLRRDGRDLVPTAKARQLMALLSGLDVSELTSPELTGEWEHKLKQIEQGALDRAAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRFACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGCISKMGRPFAAILRISGEYKLEFDFGQNDEEDNEAVDFSGHTPVGACPKCSARVFEHGMSYVCEKLVGLQKSCDFRSGKVILQQEISREQMEKLLTAGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRGDKPGRPGAAAKKAAGKTATKTAAKAPAKTAAKKAVKKAAPKKAATKTAAKKAAKKSAA
(1824) DNA topoisomerase [Nitrosomonas sp. AL212]
5
MGKSLIIAEKPSVAADIARALGSFTKNTDFFENDQYVISSAVGHLLELAIPEEYEVKRGKWSFTNLPVIPPHFDLNPIEKTSSRLKLLSKLIKRKDIDSLINACDAGREGELIFYYILRHVGTDKPVKRLWLQSMTPDAIREGFTRLMDSSEVKSLAEAAVSRSESDWLVGINGTRAMTAFNSQEGGFHKTTVGRVQTPTLAILVEREEKIKKFRPQDYWEIHATFTTSNGDYTGKWFDEKFTKDKINQESKPERLWEQTKAAIIRDKCQGKSGHVNEESKPSKEICPLLYDLTSLQRDANSRFGFSAKATLGLAQALYEKHKVLTYPRTDSRALPEDYIGTVKDTVQNLENTDYGKFCRQILASNWVVPNKRIFNNAKISDHFAIIPTSLNPTKLNEAEAKLYDLVTKRFLAIFFPAAEFLVTTRITRIENEPFKTEGKVMVNPGWQAVYGKSTKPDNAEDDNTLVAIIPGESVITEAIDIVANQTRPPARFNEATLLSAMESAGKLVEDEELRAAMSAKGLGTPATRAAIIEGLVFENYIQRVGRELHPTAKAFSLITLLRGLKIPELISPELTGNWEFQLRQIEQGNLKRTAFMEKIAEMTRHMVEQAKTHRGETIAGDFAVLKSPCPKCGGIVHETYKKFQCQKCDFALWKILAGRQFEVEEMETLITRHEVGPLQGFRSKMGQPFNAIIRLTDTLEMKFDFGNNDENQEEIDFSEQLPLGKCPKCNHAVYEHGMQYVCEKSVGAARTCDFKTGKIILARPIDRAQITKLLETGKTDLLTKFISKKGRPFSAYLVRNSDGKIGFEFEQKTAKKTTKTKSKTKQSKTRSTGNIAS
(1614) DNA topoisomerase [Verminephrobacter eiseniae EF01-2]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENERYVVTSAVGHLVEIQAPEQFEVKRGKWSFAHLPVIPPYFDLKPVDKTKGRLNAVVKQARRRDVGALINACDAGREGELIFRLIEQYAGGDKPLGKPVERLWLQSMTPQAIRDGFAALRPEQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRQFVSRDYWEVHALFGAAAGPYPGKWFNPQWKKSDDAEARAERLWSVAEAQAIAQAVRDQPASVSEESKPSTQAAPPLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFEMLAGSAMRHLAPHALTALNNGYVRMSRRIFDSSKVSDHFAIIPTLQAPGGLNDAEQRLYDLVVRRFIAVFFPNAEYTVTTRISTVSVAPNGGAAAVHRFKTEGKVLVKTGWLAVYGKEAADEVEGGKEGDKGQNLVPVQPGERVLTLQADPRGFKTKPPARYSEATLLGAMESAGKQLDDDELREAMQAKGLGTPATRAAIIEGLLTEKYMLREGREIIPTAKAFQLMLLLRGLQVEELCRADLTGEWEFKLAQMEKGQLSRAAFMADIAAMTERMVTKAREYDRDTIPGDYATLQAPCPNCAGVVKENYRRYACAGKDGASPCGFSFGKSPAGRTFETAEAETLLRERKIGPLEGFRSKAGWPFSSEIVIRYDEQTHNYKLEFDFGDDRKNAEESGALVEFKDAALGPCPLCGAGVHEHGNNYLCSKSVPTAAQPAPSCSFKSGRVILQQPVEREQMQKLLATGKTDLLDKFVSMRTRRAFKAHLVWDPAAGKVNFEFAPSKFPPRQPVAAAAKTSAHVGHAGHAGRAGSALKADRAVAAKKAPVKRVAAKVKAAAAKPPRKAA
(1287) DNA topoisomerase [Polynucleobacter necessarius subsp. asymbioticus QLW-P1DMWA-1]
5
MDNPKALIIAEKPSVANDIAKALGGFIKHEDYFESDDFVISSAVGHLLEIAAPEEYDVKRGKWSFANLPVVPPYFDLRPIAKTEARLKVLQKLIKRKDINSLINACDAGREGELIFRLIAQHAKASQSVKRLWLQSMTPAAIRDGFTHLRTDDEMQPLADAARCRSEADWLVGINGTRAMTAFNSKSGGFFLTTVGRVQTPTLSIVVEREELIRKFVSKDYWEVKAEFIASAGIYEGRWFDPKFKKDVTEPDARENRLWSEAAAQSIVAACRGKKATVTEEAKPATQLAPQLFDLTSLQREANARFGFSAKNTLGLAQALYERHKVLTYPRTDAKALPEDYLDTVKQTMENLSEHSSEYRSFAKQILQGDPKDPKTKAGYGWIKPNKRIFDNSKISDHFAIIPTLETPKTLSEPEAKLYDLVVRRFLAVFYPAAEFRVTTRITEASGHHFKTEGRVLVNPGWLTVYGRSNQADDELVPVKEGETVQTESIAAIPLKTKPPARYTEATLLSAMESAGKWVDDDEMREAMAEKGLGTPATRAAIIEGLLAEKYMVREARELIPTAKAFQLMTLLRGLDVEELTRPDLTGSWENKLSLIEQGKMKRDTFMQEIAQMTQRIVKRAKEYDSDTIPGDYATMSTPCPHCKGPVKENYRRFACEKCGFTISKTPGGRAFEYPEVEELLREKTIGPLQGFRSKMGRPFAAIIKLSEIPEDDADYPNAGFKLEFDFGNTQDDETEAIDFTGRLALGACPKCSGAVYEDGMRYVCESNTGPNKSCDFKTGKVVLQQEISQEQVQKLLKEGKTDLLTNFKSNRTGRGFKAYLALGADGKIGFEFEAKAPKAGGAAKAPAKKRAGASAATKSVAKPKRASKAKSSSSS
(661) DNA topoisomerase [Burkholderia xenovorans LB400]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEDYEVKRGKWSFANLPVIPPHFDLNPIAKSESRLKVLTKLLKRKDVDRLINACDAGREGELIFRLIAQHAKARQPVQRLWLQSMTAGAIRDGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCSAGFYEGRWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRGQIGTVTEESKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKETLGMLKESNNYLPFAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLSVFFPAAEFKVTTRITEVVGHHFKTEGKVLVEPGWLQVYGREISGEDANLVPVQKDEKVKTDRIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLIREGRDLIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACSKCEFSISKIPGGRQFEIPEVEELLQNKTIGPLSGFRSKMGRPFSAILKLSFDDEIKNYKLEFDFGQDAGGEDGEPPDFSDQQPVGACPKCKGRVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKEPSAKTVAKTAAAKAAAEAADSESEDGGAPVAVKAAPAAKKAAAKKAPATKTAAARKAPARKTAARKTGS
(1504) DNA topoisomerase [Burkholderia xenovorans LB400]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQLKRWSIEQLPIIPQNWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSASGQSFTAQWVPPDAYTDDTGRCLQQPVAQRAAQQIRGAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVSTVLDSLLRTDPSLRPIMDQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTVANLACGQQKLAATGKQVVVKGWPLVLTEPQPDEDGDAAARSQVLPALREGLACLVADVDLKALKTLPPRPYTQGELVKSMKGVAKLVTDPRLKQKFRDTVGIGTEATRANIISGLIARGYIVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYSIASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRGASRPHRSGRQGS
(1170) DNA topoisomerase [Burkholderia sp. YI23]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDDYVISSAVGHLLEIAAPEEYDVKRGKWSFTNLPVIPPHFDLNPIAKSESRLKVLTRLMKRKDIDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIREGFANLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFIAAKGIYEGRWFDPKFKRVENDPEQRDSRLWSLAAAETVVAACRGKTGTVTEESKPSTQMSPLLLDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYLSTVKDTMTMLKESNNYLPFAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLSVFFPAAEYLVTTRITEVSGHHFKTEGKVLVEPGWLQVYGREAAGEDGNLVPVQKNESVDVEKVEAHGLVTKPPARYNEASLLSAMEGAGKLVEDEELRDAMAAKGLGTPATRAAIIEGLLGEKYMVREGRELIPTAKAFQLMTLLRGLGVEELTAPELTGQWEHKLSQMERGSLHRDQFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGSQVKENYRRFACTKCEFSISKIPGGRQFEIPEVEELLREKTIGPLSGFRSKMGRPFSAILKLALDDEIKNYKLEFDFGQDSGGEDGEPPDFSEQTPVGACPKCQSRVFEHGMSYVCENSVSNPKTCDFRSGKVILQQEIAREQMQKLLGDGRTDLLTNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEAKPGAKTAAAKRGAAADAQSDSGDESGDSDVAVAAKTTRAKPAAKKAPAKKAAVKKTAARKTG
(1385) DNA topoisomerase [Burkholderia gladioli BSR3]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDDFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDIDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAKLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWYDPKFKRDEHDPEKRDSRLWALPAAETIVAACRGQIGVVSEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKQTMEMLKESNNYLPHAKQVLDKGWVKPNKRIFDNAKISDHFAIIPTLQAPKALSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDKVAAHQLVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLIREGRELIPTAKAFQLTTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDTFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIPEVEELLQKKEIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEDGEAPDFSAQEPVGACPKCGARVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLSDGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKPGAAAKKAAAKKTAAAANEDGAGSDAAEAAVPAKKMAAAKKAPAAKKTAAAKKTPARKTGS
(1840) DNA topoisomerase III [Albidiferax ferrireducens T118]
5
MCERPGAREKLDCSQMKTLIIAEKPSVAQDIVRALTPVAGKFDKHDEHFESDSYVVTSAVGHLLEIQAPEEFDVKRGKWSFAHLPVIPPHFDLKPVDKTKTRLNAVVKLAKRKDVDQLINACDAGREGELIFRLIEQYAGGAKPLGKPVRRLWLQSMTPQAIRDGFNTLRSNEQMLPLADAARCRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRAFVSRDYWEVHATFAAQAGDYPAKWFDPQWKKAAANAAAGNLEEADPELKADRLWQQREAQAIADAVRGQTASVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYLPVVKQTFEMLSKSAMRHLAPHALTALNNNYIRPSKRIFDNSKVSDHFAIIPTLQAPSGLSEAEQKIYDLVVRRFMAVFFPNAEYQITTRISVAAGHSFKTEGKVLVKPGWLAIYGKEAVDEVTDRDGAKDGDKGQRLVPVQAGERVTAQTVEARGLKTRPPARYTEATLLGAMEGAGKTIEDDELRAAMHEKGLGTPATRASIIEGLLTQKYMLREGRELIPTASAFQLMTLLRGLDVKELSKAELTGEWEHKLALMEHGQLSRAEFMAEIAAMTERMVKQAKEYDRDTVPGNYATLTAPCPNCGGIIKENYRRYTCTGKTGAEEGCGFSFGKTPAGRTFEVAEVEQFLRDKKIGPLEGFRSKAGWPFTAEMVIKFDEESKNYKLEFDFGDDKKGEESGELIDFSGQESLGACPKCGAPVFEHGKNYVCEKSVPTDAQATPSCDFKTGQIILQQPIEREQIAKLLATGKTDLLDKFVSMRTRRGFKAMLAWDAEAGKVNFEFAPSKFPPRKTAAKSAAGASVAAKTGAARAATTGAAAKKAAKKVASPKAAAKASAKTPRKAAVKKVASPAAGLQPSAALAAVIGAEPVARPQVIKKLWDYIKANNLQDAVNKRNINADAKLLAVFGKPQVTMFELAGIVGKHLA
(1785) DNA topoisomerase [Cupriavidus taiwanensis]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAKTESRLKVLNRLIKRKDVTTLINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFAALREDEDMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKNEFDPEARESRLWSEAEAKSIVAACRDKPGTVTEESRPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKQTMDMLADSSPNYLPHAKKILAQGWVRPNKKIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKVEGVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMREIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENYRRFACTACEFSISKIPGGRQFEIEEVEELLQKKEIGPLQGFRSKMGRPFAAILKLGKDDEGHYKMEFDFGQNDDDNDGEPVDFSGQQPVGTCPKCGGSVFEHGMKYVCENSTTSPKSCDFTTGKIILQQEISREQIGKLLNEGKTDLLTGFKSSRTGRNFKAFLVKQPDGKIGFEFEAREPKAGAKSAAKAPAKAASRGTAEAEAAPATKTAAKTASKTAAKTAAAKAPAKKAAAKKAPAKTAAAKKTRAAAAGE
(943) DNA topoisomerase 1 [Pseudogulbenkiania sp. NH8B]
1
MPSSLLIVESPSKAKTLKKYLGQDFEVLASYGHVRDLVPKSGAVDPDKNFAMKYQLIPRNAKHVDAITQAVAEADHIYLATDPDREGEAISWHLVQILNNKKLLKGKTAQRVVFHEITKNAVLDAIANPRDISQELVDAQQARRALDYLVGFNLSPMLWKKIRRGLSAGRVQSPALRLICERENEIRAFTEQEYWSIHLDSHKGRQKFGAKLFELGGNKLDQFDIPSEAVQADTLARLAEQPATVSNVDKKKKTRNPAAPFTTSTLQQEAVRKLGMTTDRTMRTAQQLYEGVDIGQGTVGLITYMRTDAVVLSNEALTEIRGYIESQFEPAFLPKAPVTFKNKSKNAQEAHEAIRPTSIERTPAAMKPFLTTDQFKLYEMIWKRTLACQMAPAKFDTTSVDITVGEGVFRATGQVQTFAGFLAVYEEDVDDAEDEDNAKLPALEVGDVLPVDKLYGEQHFTQPPPRFSEASLVKALEEFGIGRPSTYASIISTLKDREYVVLDKKRFLPTDTGEIVNKFLTEHFGQYVDYNFTAKLEDQLDEIANGRREWVPVMETFWKGLAKQLSEKESLSRAEVTTESLDEACPKCSKPLQIKFGKRGRFIACTGYPECDYTRDIGETAESAAAAAEEPTVIEGRTCPECGGALHIKKGRYGKFIGCANYPKCKHIEPLEKPRDTGVTCPECKTGSLIERKSRYGKLFYSCNTYPKCKYATWNPPVAEPCPKCHWPILTIKTTKRRGTEKVCPQKECGYSEVIAPPEAKEA
(1784) DNA topoisomerase 1 [Laribacter hongkongensis HLHK9]
1
MPANLLIVESPSKAKPLKKYLGADFEVLASYGHVRDLVPKNGAVDPEHDFAMKYQIIAKNAKHVDAIASAVREADNIYLATDPDREGEAISWHLLQILQSKKLLKDKNVQRVVFHEITQNAVLDAVAHPRNILQELVDAQQARRALDYLVGFKLSPLLWKKIRRGLSAGRVQSPALRLICEREAEIRAFETREYWSVHLDSHKGRQKFSARLTDWLGRKLDQFDIPDETSQAGILAALAGKPASVTAVEKKKKSRSPAAPFTTSTLQQEAVRKLGMTTDRTMRTAQQLYEGVDVGQGQVGLITYMRTDAVVLSNDALTEIRYYIGEHFDADYLPKSPVSYKNKSKNAQEAHEAIRPTSIFRTPESVKPFLTPEQFKLYTMIWKRTLACQMAPAKFDTTAVDITVGDGVFRASGQVLTFPGFIAVYQEDKDSDDAAAGDDDEARLPVLEVGDELPVDKLYGEQHFTQPPPRYSEASLVKALEEYGIGRPSTYASIIKTLKDREYVTLEKKRFEPTDTGDIVNKFLTEHFEQYVDYNFTARLEDQLDDISNGKRQWVPVLDSFWQGFKKQLEEKEGISRAEVTTQQLDEACPKCGKPLNIRFGKRGRFIGCTGYPECDYTRNLNETAEEAAAAAAAEQEELVVIEDRVCPEDGGQLVIKKGRFGKFIGCANYPKCKHIEPLEKPRDTGVTCPVCKTGHLVEKKSRYGKLFYSCNTYPKCTYAVWNPPVAENCPQCGWPVLTIKTTKRRGTEKVCPQKECGWSEVIAPPAGKDEAPAD
(1018) DNA topoisomerase [Burkholderia thailandensis E264]
5
MCYKAVVKGPASGSPGPSIHTVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDVDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDQLGTVTEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDETKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQADGKIGFEFEKKEPKPAAAKKTASKSTAAAADAAADSDDKAEKKTAPARKTAARKTPARKTGS
(1112) DNA topoisomerase [Burkholderia rhizoxinica HKI 454]
5
MRLRPICYKAFDSAHPYFPIVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDDYVLSSAVGHLVEIAAPQEYEVKRGKWSFAHLPVIPPHFDLQPIAKSESRLKLLTRLIKRKDVDRLVNACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPAAIRDGFAQLRSDQEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCATGSYEGRWFDPKFKKNEFDPEQRDSRLWSAAAAETIVAACRGQIGTVSEESKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLALAQALYERHKVLTYPRTDARALPEDYMAAVRDTLEVLKESNNYLPFAKQVLDKGWVRPNKRIFDNTKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVVGHHFKTEGKVLVAPGWLQVYGRETSGEDANLAPVAKDEKVQTDKIAAQQLTTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVEELTAPELTGEWEHKLSQMERGRLEREAFMREIARMTQTIVKRAKEYDSDTIPGDYATLKTTCPNCNGEVKENYRRFACTKCDFSISKIPGGRQFEIDEVEQLLSEKSIGPLSGFRSKMGRPFSAILKLARDEEANNYKLEFDFGQDTMGEEGEAPDFSSQEPVGQCPKCHARVFEHGMSYVCENQAAHPKTCDFRSGKVILQQEITREQMAKLLDQGRTDLLTNFKSSRTGRNFKAFLVKQKDGSIGFEFEKKEPAAKTAAKSSTRGAKANSGAGDAGPDTTQRGDSHRATSLKPAAKRATRTATATAGPAAKTTARKTPARKRAAG
(1292) DNA topoisomerase [Burkholderia multivorans ATCC 17616]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFACAAGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYIGTVKSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEYRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVQVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDEIKNYKLEFDFGQDQGGDEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMAKLLADGRTDLLPNFKSSRTGRNFKAYLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDTETVTEGADEKPAPARKTAARKTTTRKTGS
(1291) DNA topoisomerase [Burkholderia multivorans ATCC 17616]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFACAAGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYIGTVKSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEYRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVQVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDEIKNYKLEFDFGQDQGGDEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMAKLLADGRTDLLPNFKSSRTGRNFKAYLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDTETVTEGADEKPAPARKTAARKTTTRKTGS
(1646) DNA topoisomerase [Ralstonia pickettii 12J]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDEYVLSSAVGHLVEIAAPDEYEVKRGKWSFAHLPVIPPHFDLRPIAKSESRLKVLTRLIKRKDVTGLINACDAGREGELIFRLIAQHANTKLPVKRLWLQSMTPQSIRDGFGKLRSNEDMMPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKRFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKDEFDPERRDSRLWSEAEAKSIVAACRDKPGSVTEESKPSTQMSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYMGTVKQTLDMLGESSPNYLTHAKKILANQWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEYQVTTRVTEVAGHHFKTEGKVLVNPGWLVVYGREAQGEDANLVPVAKDEKVKTDKVEPVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVEELTQAELTGGWEHKLSLIERGQLERDEFMREIAQMTQQIVKRAKEYDSDTIPGDYATLSTPCPQCGHVVKENYRRFACSHCDFSISKIPGGRQFELDEVEELLTNKTIGPLQGFRSKMGRPFAAILKLAQEDGHWKMEFDFGQNDEDDGEPVDFSGQESVGHCPKCNGNVYEHGLKYVCENAVAQPKTCDFTTGKIILQQEISREQLAKLLTEGKTDLLTGFKSARTGRNFKAFLVKQPDGKIGFEFEPRGEGKGKPGAKTAAKKTTAAAKTPAAKKAPAKTAGKTAAKKAPARKKATEAETDEESTSET
(1730) DNA topoisomerase [Janthinobacterium sp. Marseille]
5
MTKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDEYVLSSAVGHLVEITVPEEYDVKRGKWTFTHLPMIPPHFALNPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQYTKAKQPIKRLWLQSMTPGAIREAFKNLRSDDEMLPLADAARCRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVRAEFICAAGIYQGRWLDTAFKKDETDPERRAERLWSKAAAESIVAACRGKQGNVTEESKPTTSMAPALFDLTSLQREANARFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYLPTVLQTLDVIAENNNYHQFAKQITDNKWVKPNKRIFDNTKISDHFAIIPTTQAPKNLSEPEQKLYDLVTRRFMAIFFPAAEFQVTTRFTEVSGHQFKTEGKVMTNPGWLAVYGKEVIDEKDPENSGTLVPVAKGEKVKTESVVANGLVTKPPARYSEATLLSAMEGAGKLIDNDGLRDAMAGKGLGTPATRAAIIEGLLNEKYLLREGREMIPTAKAFQLMTLLRGLGVNELTAPELTGEWEYKLSEMERGKISREEFMREIAQMTQVIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKTPGSRQFEIAEVEELLTNKTIGPLQGFRSKMGRPFAAVLKISRDEEIKNYKLEFDFGQNDDDENAEAVDFSGQTSLGPCPKCAGGVYELPLSYVCENSVAKPKTCDFRSGRIILQQEILPEQMSKLLNEGKTDLLPGFVSQRTRRAFKAYLVRGKDGKTSFEFEPRKEKAPAKGKAAAVADDAAEAGDDTAVAAKPAKKAAAKPAAKKAVAKKKAPAKKAAAKA
(401) DNA topoisomerase III [Polaromonas sp. JS666]
5
MKTLVIAEKPSVAQDIVRAITPTAGKFEKHDEYFESDEWLVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFEVKPIDKTRTRLNAIVKLAKRKDVGAIVNACDAGREGELIFRLIQQYANSKHPVKRLWLQSMTPAAIREGFDSLRSEKQMQGLADAARSRSEADWMVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRKFVSRDYWEIHASFLAEAGEYPAKWFDPKWKKAAANADNAEPDAELRADRVWSEREALAIAEAVRGKAATVTEESKPTTQAAGLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYLPVVKQTFEMLADSGMRHLAPHAATAIKGNYIKPSKRIFDNAKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFYPSAEYLVTTRISQAVGYSFKTEGKVLVKPGWLAIYGKEAADEVADAKDGDKGQSLVPVKPGEMVRAEVVEAKGLKTRPPARYSEATLLGAMEGAGKTIDDDELREAMQEKGLGTPATRAATIEGLIAEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSKAELTGEWEYKLAQMEHGKLSRETFMAEIAAMTENLVNKAKGYDKDTIPGDYTTLQTPCPNCGGVVKENYRRYTCTGKNGGDGCGFSFGKTPAGRTFETAEVEQFLRDRKIGPLEGFRSKAGWPFTAEMVIKFDEETKNYKLEFDFGDDKNGETGEIVDFGDQQSLGPCPRCAARVFELGKNYVCEKSVPTLEQPTPSCTFKTGQVILQQPIEREQMHKLLETGKTDLLDKFVSMRTRRPFKAMLAWDKEADKVNFEFAPSKFPPRKPAAAKTGVVKTPFGKTVAAKGAAGDAAPAAKKAAAKKVAAKKAPAKTAAPKVARKAATPKPGAGLKPSDSLAAVIGAEPVARTQVIKKLWDYIKAEGLQDAANKRAINADAKLLPVFGKPQVTMFELAGIVGKHLS
(1783) DNA topoisomerase [Herbaspirillum seropedicae SmR1]
5
MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGKWSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQYTKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDKGHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFSKQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPAEFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKTDKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLLNEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFMREIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVPGGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAEGEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPEQMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAKAPAKGKAAAADADDGADEAVAKPAAKKTATKTAAKTTATKAKAAAAKKPALRKATPKKAAAPDA
(76) DNA topoisomerase [Alicycliphilus denitrificans BC]
4
MRVFLCEKPSQGKDIARVLGAGQRSNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQYKRWAIEQLPIVPERWRVEPKVATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAADVLLSHAGQSFTASWIPPEGSTDAAGRCLQQPVAQQAVDRIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSRQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPAVLDALLATEPSLRPLLGQLDRNQRSRAWNDGKVTAHHGIIPTLEPAKLLAMSEKELAVYQLIRGRYLAQFLPHHEFDRTVTQLACGGQSLVAVGKQIAVIGWRQVLATPEPDAADGEEAQRSQVLPPLASGSRCGVEQVELKALRTLPPKPYTQGELVKVMKGVAKLVDDPRLKQKLKETTGIGTEATRASTIKGLLDRGYLLKKGRAIRASDAAFTLIDAVPAAIADPGMTAIWEQALDMIEAGQMTLDTFIAKQSTWVAQLVQQHRGATLSIALPPSPPCPQCGAPMRQRTGKSGAFWSCSRYPDCKGTLPVESSASKRGAPRKRRTVPKAS
(859) DNA topoisomerase III [Alicycliphilus denitrificans BC]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLAAVVRQAKRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFEHLRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFQAEAGQYLGKWFDPKWKKSEDPEARADRVWSLKEAEAIAHAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKNTFAMLAGSGMRHLAPYAQQALDDGYVRPSRRIFDNAKVSDHFAIIPTTQAPHGLSEAEQKLYDLVVRRFMAVFFPSAEYLVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAASEVEGGKEGDKGQPLVPVKPGEMTHTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDEELRSAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLQVEELCRAELTGEWEYKLAQMEKGQLSREAFMQQIQAMTEKLVRKAKEYDRDTIPGDYATLATPCPNCGGVVKENYRRYACTGAGGSGEGCGFSFGKSPAGRTFETAEAEQLLRERRIGPLEGFRSKAGWPFTAEVTIARDEEAGNYKLEFDFGDDKNAEESGEIVDFAGQESLGRCPVCGAPVYEHGGNYVCAKAVPTAQQPVPSCSFKSGKVILQQPVERAQMHKLLATGKTDLLDKFVSMRTRRPFKAFLAWDAAAGKVNFEFEQRESKYPPRKTAAAAKTGAASARGTGAAGPKTSKPAAKKTAAAKTPRKTGAAGKTPSAQLAAVIGAEPVARPEAVKKMWDYIKAHNLQDPKDKRTIVADDKLRAVFGKDSIGMFELAGVLGRHLA
(1209) DNA topoisomerase [Sorangium cellulosum So ce56]
7
MIAVVAEKPAVARDIAAVLGASKRAEGFLEGGGYVVTWAIGHLVAIAEPHQIDPAWKRWRLDLLPMLPGQFPLVVLPGTRAQFEIVRKVLGRRDVERVVCATDAGREGELIFRYIYEAAGCKKPVERLWISSLTPDAIRDGLRRLRDARGYDGLADAARGRSRADWLVGMNLSRAYSLVFDQDLSVGRVQTPTLSMVVERELAIRRFVPEPYLEVVATFCPLREDASGAADESYKGTYFNDKPVPGEPPGAGERPNAGERPNAGERPNAGERPNAGERPNAGERPETAPSRRRLPPDGEEARRIIERARRGEARIEAVRSESRRLPPPLLYDLTELQRHANRLYGFSAQKTLEVAQALYERRKLISYPRTDSRHLSTEVAATLGAAVQAIEGSYRGMLAPGTGARPLGKRFVDDGKVGDHHAIIPTGARSSRAELSTDEQKIFDLICRRLLSAWHEDHVTSITTVITAITTRGGAGARGGEPIVDRYHSAGSVVEKVGWKVLDIGFGKPPARPRRKGESDGDGPDAPDARDGEGGEGERETADQRLPPGLARGQVQLVLDAEAQAKKTRPPPRFTEATLLTAMETAGSSLEEKELSAAMKDSGLGTPATRAAIIETLLRREYIVRKGKLLHATDKGVGLIEVVHADVKSPAMTGAWEAKLARMARGGGDLPSFMAGIESYVRQVVAEVSAGRRAAGGGALSPEAGASPFQERGEARSRAKGDRAAAAAPGTGRGREATPRRAPGSSAGAVPGDASAGTLQAVAAAAAASPPARAQARSRAAAPSPARPAAATARRVAVAPSTARPVAATSPPARSAAIAPSLARPAAATSPPARPAAVAPPPARAAAIGSFPARGAGTASSPAVASSPARRPEDLVELLHQCFGFSAFRPYQEAVCRTAAAGSDVLLVMPTGAGKSLCYQLPGIARGGTTLVVSPLIALMEDQASKLRACGFAAERIHSGRSRAESRKACIDYLEGALDFLFIAPERLRVPGFPELLARRKPVLVAVDEAHCISKWGHDFRPDYRMLGQRLPALRPAPVIALTATATPVVQDDIVEQLGLASAARFIHGFRRSNLGIEILEVSPGERLARVRALLGQEGRTPAIVYAGTRKDAEALAAGLSEDLPAEAYHAGLAAPVRDRIQAAFLDGSTEIIVATIAFGMGIDKPDVRTVVHAGLPGSVEGYYQEIGRAGRDGLPSRAVLMHSYVDRRMHEFFHERDYPDPAMLQRIEEVLSEEPRPKEAILGDLGIDPEVADKALEKLWIHGGARVDPDGGIALGEPGWRGPYEAQRRHKLAELVQMARFTEGHGCRMLHLVRHFGDQEDTGEPCGLCDVCAPAACAAREFRAPSRDEAQAIAKILAALRESEQPTGRLYREAFADGSLERRDFEHLLGGLVRAGLVCVREDSFEKAGELITYQRASLTSRGLLGGPRGASDVVGDVPLAKLPPKVKKRQSATSSDARRAFFARKAQRKKGRSR
(742) DNA topoisomerase 1 [Sorangium cellulosum So ce56]
1
MAKTLVIVESPAKAKTIKKYLGNGYEVFASKGHVKDLPKKQNAVDVQNDFAETYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIAFHISEEIKNPKLKVARVEFHEITKKGVDHGVHNPRKLDENLYDAQRARRVLDRIVGYDVSALVWSKLAFGLSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAKLASADGKKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQDATNYLHFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVVAKRYGKEFVPERPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLYKLIWNRFVASQMTPAVYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQEFAGEEESAGAAADGGAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPPGVITDQKFTQPPPRYNEGSLVRELEKRGIGRPSTYAEIISKVQQRAYVEKRDGGAFQPTLLGKFVVDGLVRSNLDIMDPNFTAQMEEELDAVGAGSLKREQLLKSFYKKFREQLDKSKKLAPWKPEAEKTDIVCDECGSMMLKKWGKNGWFLSCERYPKCKATRDLSDARGTAAVRETDISCDKCGKPMIIKTGRFGDFLSCTGYPACKNTRPVPLGVACPSCGGDLIEIRPRKKGGRTFYGCSNWNAEQKCEFKLWQKPVPVPCPQCGAKFVTRTAGKKAMLVCATKDCGFKQEIVEGEGEDGAADGAATPDAAAVVASAAPAPAARPAPAEPTPAGRPEAAPEGAGAAQGAAEKPARAVRARRTAS
(1758) DNA topoisomerase 1 [Haliangium ochraceum DSM 14365]
1
MADQQAISKKRANDPANQADAADDNTSAKGATSEKSASKKAASPSKKTSTKKASTKKTAKKASTKKASTKKTTKKASAKKASAKKTAKKASAKKTTKKASAKKASAKKSASQEAAEDEGESAPKRTKSRSKATKQGKALVVVESPAKARTIGKYLGPDYTVKASVGHIKDLPKNKIGVDVDQAFEPEYVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAWHIAEEIKPINDNIKRILINEITKKGVNHAIANPTVLDTNKTDAQQARRILDRLVGYEISPILWKKVRRGLSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHRWDGAKAEPKTEAQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEASRKLRFSAKRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQGTYGPEFLPAKPHTYKSPKRAQDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYTLIWQRFVASQMAPAVYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAADQDKLLPHLEEGMAIHFDAIRPEQHFTQPPPRFTEASLVKELEERGIGRPSTYASIISTITDRGYVERREARFFPTELGAIVNDLLVESFPKIMDVDFTAAMEADLDKVEEGERDWRELLGGFYEPFRGNIEHAKENMRDVKREEIPTDHVCEKCGAPMVIKWGRNGSFLACQAYPDCRNTKEINRNPDGSFEIVPEQTTDETCSECGAPMVVKRGRFGAFLACSTYPECKNTQPISLGVDCPKDGCGGFLTEKRSRRGKPFYGCSNYSKTGCDFVTWDRPIAEACPVCEASFLVKKETRRGTTVRCLSCDYKTEQAGESAA
(993) DNA topoisomerase [Haliangium ochraceum DSM 14365]
7
MTATTLIIAEKPSMARDIARVVGARSKREGYLEGGGYWVSWCIGHLAELCEPHEYDAKWKSWSPSLLPILPDELRVRPSRSGAAHLRVLHRLMRAREVGTIVNACDAGREGELIFRHVHALSNTRKPVRRLWISSLTGEAIRRGMSALRPGAEFDDLADAARARADADWLVGMNATRALTGLVRSGGTRGLLMSVGRVQTPTLALIVRREREIESFESKPFWQVLATFAVPGEAGASYEGIWQRPREAGDDAGDAQRDNKGDAQRDNKGDGDTNTARDRSRVPTRQQADAIADAVRGRAGTITQLTRKSTRERPPLLFDLTNLQKLANRRFRMSAKRTLELAQALYETHKLITYPRTDARYLTDDLAPTLPELVRALAGEYPGLRDTALAGAAHAAGNRRIFDNAQVGDHHAIIPTAKAPSPGRLSADERRLYDLIARRFLASLFPDAVYDQTKIVTTVAGHCFATERRVCAEPGWQQAEPPPPAKRNEPPLPRLRQDMEVDTAAIEVREGKTQPPKRYSEASLLGAMEHAGRSLDDPGLRRVMRDAGLGTPATRAAIIETLLKRSYIERQGRELVPTEQGRALIASVPIEDLLSAELTADWEQKLDAIARGRASKARFMDEIHGYVRRIVDALAQATPPSLPSPTDEVLGLCPVCNGVVTEGFKTFQCASGKSCSFVIFKRIAGRKTSAALVRVLLARGRTQTLKGFRSKRGKRFSAVLTLDAEGKVQFAFDNPRGGATKSAGSAKGAKKSASSASGAKKSAASASGAKSAAAGGSGPRCPACRQGRIITGRRAWGCSRWREGCGFTVGFQQGEVRVSEEQAERLFRRGQTVLLDGLMPERRARLVLDLEAEGNVRVEPGKRARRT
(1781) DNA topoisomerase [Thauera sp. MZ1T]
4
MRVFLCEKPSQGKDIARVLGAVQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQYKRWAIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSMPYWAVDVLLSHAGQSFTASWIPPEGSTDAAGRCLQQPVAQQAADRIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLDSLVKTDPSLRPLIERLDRQQRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLICAHYLAQFLPHHEFDRTVAQFSCGSQSLAAVGKQIAVTGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLKALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYLVKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMALDTFIEKQSVWVGQLVQQYRGATLSLKLPPAPACPQCGAPMQQRTGKSGAFWSCSRYPDCKGTLPLESPTGRRSAPRKRRAASKAS
(1392) DNA topoisomerase [Thauera sp. MZ1T]
5
MSKQLIIAEKPSVAQDIARALGGFTKEKDYFESDEYVLSSAVGHLLELTLPEEFEVKRGKWTFAHLPVIPPHFAVKPIEKTEDRLKLLTRLIKRKDVTGLINACDAGREGELIFNFIAQHAGTKKPMQRLWLQSMTAQAIRDGFAHLRAAQDVEGLRNAAICRAESDWLIGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLAMVVEREDRIRKFKSRDYWELEARFGCAAGEYPGRWFDEKFKRPEGDEHATAFRLWDKAQAEAIRAKCAGKPGVVSEEAKPSTQLSPLLFDLTSLQREANGRFGFSARVTLQLAQALYEKHKVLTYPRTDARALPEDYLATVGEVMRTLPDQYAPFANEITRQGWVRPNKRIFNNAKISDHFAIIPTGALPKSLSDAEHKIYDLVTKRFLAVFYPAAEYQITTRITRVEGEAFKTEGKVLVNPGWLTVYGKEAANDEKDAKDGGAPQLVAVKQGETVSTEDIVVKSLQTKPPARFNEATLLSAMEGAGKMVDDEELRAAMAERGLGTPATRAQIIEGLISEQYIHRDGRELIPSAKAFSLITLLKGLGVTALTSPELTGGWEYKLAQMEHGKLSREAFMNEIAEMTREVVERAKRYESDTVPGEFVTLQTPCPKCGGVVKENYKKFACQACDWSTWKIVAGRQFEYDEIETLLRAGKVGPLLGFRNKMGRLFNADIVLNEDKQPTFDFGQPKEGEEAEEVDFSDQQPVGACPKCASRVFEHGMAYVCEKSVGPGKSCDFRSGKVILQQPIEREQMARLLTEGKTELLKGFVSARTRRKFSAFLVRGKDGKVGFEFEAKAPKAGAKPAAGKGDEAAGEDAEPAAPRKRAARKAS
(1680) DNA topoisomerase [Dechloromonas aromatica RCB]
5
MPRHPTGQTMSKKLIIAEKPSVAADIARALGGFTKHDDYFESEELVLSSAVGHLLELACPEEFEVKRGKWSFAHLPVIPPHFALKPIEKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFNYIAQNAKSGKPVQRLWLQSMTQGAIRDGFSRLRPGQEMEGLGDAAVCRSESDWLVGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLAIVVERERKIRDFKSRDYWEVEADFTAKAGSYKGKWFDEAFKGKNDDEHARADRLWEVARAEAIRAATEGKPGEVTEEAKPETRLSPALFDLTTLQREANARFGFSAKTTLSLAQALYEKHKVLTYPRTDSRCLPEDYLPTVKETLTILTGEGAGKGHDEVLLARYSPFAHQILARNWVLPNKRIFNNAKISDHFAIIPTPQAPKSLNEMEQKLYDFVVRRFLSVFFPAAEYMVTTRITRVEGHPFKTEGKVLVNPGWLAVYGKEGQDGDEGNLVAVDAKEKVKTDEVTVKANATKPPPRYSEATLLSAMEGAGKMVDDEELKAAMAGRGLGTPATRAQIIENLIGEQYMHREGRELIPTAKAFTLMTLLNGLGIKELTQPELTGDWEWKLGRIEKGEFTRDEFMREIAEMTRHMVERAKQYEADTIPGDFGVLTAPCPKCGGQIRETYKKFQCGSCDYALWKIVAGRQYEPAEIEQLLTEKQVGPLTGFRNKMGRSFSAAIKLNDELQPEFDFGQDKADAADAEPVDFSAQESLGKCPKCAANVFEHGTSYVCEKSVGPAKTCDFRSGKIILQQPIDAAQMKKLLADGKTDLLKEFVSNRTRRKFSAYLVNQGGKVGFEFEKKVAKPKAPAKKKTEA
(1099) DNA topoisomerase 1 [Methylobacillus flagellatus KT]
1
MSKLLIVESPSKAKTLKKYLGKDFEVLASYGHVRDLVPKTGAVDPDHDFAMKYEVIDRNARHVDAIAKAVKTADAIYLATDPDREGEAISWHIAEILKSKKLLKDKLIKRVVFHEITKNAVQNAIEEPRDISMPLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWTIHLESAKHQHVFDAKLVQLEGKKVEQFTITNQAQQQEVVGKLLAVSAGKTTVSRVEKKQRSRSPAAPFTTSTLQQEAVRKLGFTTSRTMRVAQQLYEGIDIGSGTMGLITYMRTDSFSLATEAVMQIRDYIKQNFAAEYLPKSPIMYKTKAKNAQEAHEAIRPTDISRTPASMRAFLTDEQFRLYEMIWKRALACQMTQAKFDAVSIDLAVGSDANLFRATGQTLIFPGFIAVYMEGVDDEEEEGESKLPHLETGEVLAVQKIYGDQHFTEPPPRYSEASLVKALEEYGIGRPSTYASIISTLQDREYVVLDKKRFIPTDVGRVVNKFLTEHFTRYVDYGFTANLENELDDIAEGEREWIPVLNEFWQGFNNQIHEKSNVERPGVEMLDEACPKCGKPLQSRLGRFGKFIGCSGYPECDYIRNPNANANNNEPTVIGQEPESGKDILLLNGPYGPYLQIGLPEADSKKKPKRVSIPKEIPVSSLDMETALKLIALPRDLGQHPETGKKVVANIGRFGPYVNHDGKFKSIPKSESVFDIDLARAIELLAQANAGAAPIKELGNHPDGTGNIAIYAGRFGPYVQHGKLRATLPKGQEPETLTMEQALELLSAKAAKDAPAKKAKTTTAKKTSSTKKAATTTRRKKASAGESE
(100) DNA topoisomerase [Azoarcus sp. BH72]
5
MSKQLIIAEKPSVAQDIARALGGFTKEKDYFESDDYVLSSAVGHLLELAVPEEFEVKRGKWTFAHLPVIPPHFALKPIEKTDDRLKLLTRLIKRKDVTGLINACDAGREGELIFNFIAQHAGTNKPMQRLWLQSMTPAAIRDGFAHLRAARDVEGLRNAAICRAESDWLIGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLAIVVEREDKIRKFKPRDYWELEATFGCAAGEYTGRWLDENFRKPEGDEHANAHRLWDKARAEAIRAKCEGKPGVVTEEAKPSTQLSPLLFDLTSLQREANGRFGFSARVTLQLAQALYEKHKVLTYPRTDARALPEDYLGTVKDVMAGLPDTYAPFANEIAKQGWVRPNKRIFNNAKISDHFAIIPTGTLPKSLSEAEHKIYDLVTRRFLSVFYPAAEYQITTRITRVEGEAFKTEGKVLVNAGWLAVYGKEAANEDGEGKDAGKDSGRQLVAVKPGETVSTDDILVKALQTKPPARFNEATLLSAMEGAGKMVDDEELRAAMAERGLGTPATRAQIIEGLIAEQYIHREGRELIPSAKAFSLITLLTGLGVNALTSPELTGGWEYKLSRMERGELSREAFMHEIAEMAREVVERAKRYESDTVPGDFVTLKTPCPKCGGTVKENYKKFACQACDWSTWKIVAGRQFEIDEIETLLRDGKVGPLLGFRNKMGRLFNAEIKLNDDKQPEFDFGQPKEGEEGGEAVDFSGQQSIGACPKCGANVFEHGLAYVCEKSVGPGKNCDFRSGKIILQQPIEREQMAKLLTDGKTDLLKGFVSARTRRKFSAFLVRGKDGKVGFEFEAKTPKAGAKSTPAKAAANEETGKPAPRKRAGGKTAG
(792) DNA topoisomerase [Aromatoleum aromaticum EbN1]
5
MSKQLIIAEKPSVAQDIARALGGFTKEKDYFESDEYVLSSAVGHLLELAVPEEYEVKRGKWTFAHLPVIPPRFALKPIEKTDDRLKLLTRLIKRKDVTGLINACDAGREGELIFSFIVQHAKTDKPISRLWLQSMTAGAIRDGFAQLRSAQEVEGLRSAAVCRAESDWLIGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLAIVVEREEKIRRFKPRDYWELEATFGCKAGRYVGRWFDESFRKPEGDEHATAFRLWDRARADAIKAKCDGKPGIASEESKPSTQLSPLLFDLTSLQRDANGRFGFSARVTLQIAQALYEKHKALTYPRTDARALPEDYVGTVKDVLHALPDDYAPFAGEIMKQGWVRPNKRIFNNAKISDHFAIIPTGTVPKSLSEAEQKIYDLVTRRFLAVFYPAAEYRITTRITRVENEAFKTEGKVLVNPGWLAVYGKEAAKADDEGGAQLVAVEQNERVATEDILVKALVTKPPARYNEATLLSAMEGAGKMVDDEELRAAMGERGLGTPATRAQIIEGLIAEQYLHREGRELIPSAKAFSLITLLKGLDVSSLTSPELTGEWEHKLAQMERGQLSRPEFMREIAEMAREMVERAKRYESDTVPGDFATLSAPCPKCGGVVRENYKKFACQACDWSAWKIVAGRQFEIHEIETLLRERRVGPLTGFRSKMGRLFNAEIRLNDEQQPEFDFGQPKDDGEGAEPVDFSAQEPLGPCPKCGARVFEHGMAYVCEKSVGPEKSCDFRSGKVILQQPVEREQMVKLLADGRTDLLKGFVSTRTRRKFSAFLVRGGDGKVGFEFEAKTPKAGAKGKTAAAADDEKPPVAATATAKPARAPARKRSSAA
(1420) DNA topoisomerase [Aromatoleum aromaticum EbN1]
4
MRVFLCEKPSQGKDIARVLGAGQRRNGCYSGAGIVVTWCIGHLVEAVPPEGYDERDKRWVIEQLPIIPERWRVEPKAATAAQFKIVKQLVGQATELVIATDADREGEMIAREIIELCGYRGAIQRLWLSALNDASIRKALGALKSSAETLPLYYSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSAPFWAVEVALSHAGQPFTASWTPPEGCTDEAGRCLQQPVAQQAAERMRATGSAQVASVETERVREGPPLPFDLGTLQELCSQQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLDSLVKTDPSLRPLIDRLDRNQRSRAWSDAKVTAHHGIIPTLEPANLSAMNDKELAVYKLIRAHYLAQFLPHHEFDRTVAELACGGQSLLAVGKQIAVAGWRQVLASSEEGGADSDDAQRSQVLPALRAGLSCQVGHVDLKALKTLPPKPYTQGELVKAMKGVARLVTDPRLKQKLKDTTGIGTEATRANIISGLLGRGYLLTKGRAVRASDAAFTLIDTVPAAIADPGTTAVWEQALDMIEAGQMTLDAFIAKQSAWVTQLVQQYRGTTLAIKLPPSPSPSCPQCGAPMRQRTGKSGAFWSCSRYPDCKGTLPVDTSTGKRSASRKQRASPKAS
(670) DNA topoisomerase III [Stigmatella aurantiaca DW4/3-1]
7
MGTAPEQEKTRQAGGGVAPRGPSSVLAVVAEKPAVARDIARALGATQRGEGWFRGNGYVVTWAIGHLVGLAQPHEMHPAWKRWHREQLPMLPSTWPLVVSENTRTQFEVVRAVVNAPEVSGVVCATDAGREGELIFRYIYEAAGCRKPVKRLWVSSLTEGAIREGFRTLKDGRAYDALADAAKGRSRADWLVGMNLSRLYTLACGETLSVGRVQTPTLAMLVERELAIRDFVPEDYLEVVATFAPQAAGVPAGTQYRGTWFREAEPKGGPRTAETAREARRLPADGVEAGEVMARVRSGAAVIESLTSETKRMAPPLLYDLTELQRHANRLYGFSAQRTLELAQNLYEKHKLLSYPRTASRHLSSAVAETLPEVVRAIRAPYEPLLAPGTGEKPLGRRFVDDAKVTDHHAIIPTATSPEGERLPPDEKRLYELVCRRLLAAWHDEHVWAVTTVVTAVSSVGPAPGSPRVDRFHSSGTQVVRVGWKVLDIGGGQRPPKGREGKGPKEEGEGKEPEDEPQDLPAVLARGQKQRVEDVEAVKKRTRPPPRLTDASLLTAMETAGRTLDEKELADAMKETGLGTPATRAAIIEVLLEREYLQRRGKSLEVTEKGIRLIQVVHPDVKTPAMTGQWEAWLQRIERGQGDLQAFLRGIEAYVIEVVGKMPAQPMPPRAEGPRPPPPSGAPASGAPPASVPAVSVAARAPLSAPRPASPSPSSPAAMRVRVEAPQGASKRSVERTPRAPTPPGELRKLLKEAFGFEDFRPYQEEVCKAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQVTRLQSLGFAAERIHSGRDRAASRQVCTDYLEGRLDFLFIAPERLGVPGFVELLARRPPALIAIDEAHCISQWGHDFRPDYRLLGARLPLLRPSPVVALTATATPDVQRDIVQQLGLRGSRGGASRTFIHGFRRTNIAIEVRELNPGQRGDAIRDVLAEPENRPAIVYASTRKHAEQLAERLAEEVPTAVYHAGMTPADRDRVQSAFLSGRLEVIVATTAFGMGIDKADVRTVVHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYVDRRTHEFFHQRDYPEPSMLAKLFHAAGAGLEPKEALQARVRMDPEVFDKALEQLWIHGGLEMTPDENVRRGRPEWPAPYTAQRERKMLHLEQMGRYAEASGCRMRHLVSHFGDVQDSGKPCGLCDVCAPETCVTLRFAEPGERELQALGRILDALHERDGQATGRLHRELFGEALPRREFERLIGGMVRAGLTRLSEDSFEKDGQSISFQRLTLTPEGQRTRVIEPDLVMLPMPLEAKSAKKRRATRGKAAGARLEKPRRAGTRGPPVGHSAGSASEGRQRPVAVPWGGTRERAGAVTGRSSKALSVVREWEGMDAPPATEEDWDEEQDIGVRRGGRRQPMPLPKPSPALVEALKAWRLAEARKRRVPAFRILTDRVLGAIAAARPEDREALMAIQGVGPKLVERYGAQLLALVGR
(1289) DNA topoisomerase 1 [Stigmatella aurantiaca DW4/3-1]
1
MATRKKKADETGTEAEETAAKKKAKRPAAKKAAAKKKSATKRKGSASLATVEVSADEEEEATPRGKGPHYLVVVESPAKAKTIKKYLGTGYTVKASVGHVKDLPKSKIGVDVEHDFQPEYQVIKGKEKVLNELKKAAKAVDKVYLATDPDREGEAIAWHIFEELGHKDSYRVLFNEITKKAIQEAIAQPRHLNQESYDSQQTRRILDRLVGYQISPLLWKKIRRGLSAGRVQSVAVRLICEREDEIKAFLPQEYWTLDALLEGASGPPPFKAKLSKIDGKKVELKDRETTDALVAELQGAEFTVAKVDRRERRRNAPAPFITSKLQQEAANRLHFTAKKTMTLAQRLYEGIPMGEEGQTALITYMRTDSTRLSDDAVKQVREFIGNQYGGDFLPEEPVSYRSKKNAQDAHEAIRPVSLEYPPERVRPFFEQMGEQDMFRLYELIWNRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLRVYGAGLTPEEEAEKEKAKAAGDEATDSDEATGELPPLNDGDKLRLQKLLNEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGVMTNEMLVKHFPKEMAVAFTADLEEKLDQISEGGASWKAVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNPLVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVIVEEETTDEKCENCGKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVNCPECKQGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEACPQCQSPYLLQKFSKRDGVYVACPNKECDYRREVQQPADATAPSAA
(1415) DNA topoisomerase 1 [Anaeromyxobacter dehalogenans 2CP-C]
1
MAKEPKTGAVAVKKKKAAAAPKEATAVAEAEAPKTPRRAARKTSTGTSLVVVESPAKAKTIKKYLGRAYDVKASVGHVKDLPKSKIGVDVEKGFLPEYDVIKGKAKVLSEIKRAARTADHVFLATDPDREGEAIAWHISEELGSEGGDARVRRVLFNEITKTAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFVPVEYWSLDADLAAQVPPDFRAKIFKVDGQKADLKQGEETLALVKELEGARYVVASVDRKERKRNPPPPFTTAKLQQEAANRLGFSPKKTMTLAQRLYEGVELGDEGAIGLITYMRTDSVRLATEAVDAVRAHIQQAYGKDHLPEQANVYKTKAKAAQEAHEAVRPTSLEWTPDRVAPFFDQMGERDMYRLYELIWNRFVACQMVPAVYDQTAADIAAGRAVFRATGSILKFPGYLAVYGAKPPEEEAGAEEEKSNGDAAEPAARAEDRQLPPLEAGMELRLLKLLPEQHFTQPPPRFNESSLVKEMEERGIGRPSTYAAILDTIQEKGYVEKLEKQFKPTHLGVLVTDELVRAFPREMDIAFTASMEEKLDEIEEGSAGWQRVLEEFYVSFKEDLAKADEAMRNVKAQAIETDITCEKCGQHKMVIKWGRNGEFLACPGYPECRNTMNFRREDGNIVPEKEEDVPVEDKCPECGADMVMKRGRFGRFLACTRYPDCKGTKPVSIGVTCPKGCGGYISEKRSRRGKTFYGCSSYPKCDFVAWDRPRNETCPQCGSAYLLDKYSKKTGPFVACPNKECGYRREAEPREGGAAAAQVEPAKA
(1071) DNA topoisomerase [Herminiimonas arsenicoxydans]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAATPEAYDEQLKRWSIEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLPMYHSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIVVSLSAGVQAFTAHWVPPNACTDDAGRCLQQPVAQQAMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVTTVLDSLLKTDPSLRSIIGQLDRLQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDHTVAKLSCGGQNLAATGKQVVTPGWRQVLAEPQSEDGDGDGDTAARAQVLPALHEGLACQVADIDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGNASLSIKAPQGPTCPQCGAPTRQRSSKSGPFWSCSRYPDCKGTLPVESGSSKRAASRPRRSGRKGS
(388) DNA topoisomerase [Herminiimonas arsenicoxydans]
5
MTKTLIIAEKPSVANDIAKTLGGFTKHDDYFESDEYVLSSAVGHLVEISVPEEYDVKRGKWSFAHLPMIPPYFALNPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQYAKAKQPIKRLWLQSMTPGAIREAFKNLRSDEEMLSLADAARSRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVRAEFICAAGIYQGRWLDTAFKKDETDPERRPERLWSKAAAESIVAACRGGKPGNVTEESKPTTSMAPALFDLTSLQREANARFGFSAKNTLGLAQALYERHKVLTYPRTDSRHLPEDYLPTVLETLEVVAENNNYHQFAKQILNSKWVKPNKRIFDNTKISDHFAIIPTTLAPKNLSEPEQKLYDLVTRRFMAIFFPAAEFQVTTRFTEVSGHQFKTEGKVMTNPGWLAVYGKEVIDEKDPENSGTLVPVAKGEKVQTESVVANGLVTKPPARYTEATLLSAMEGAGKLIDDSDLRVAMTGKGLGTPATRAAIIEGLLTEKYLLREGREMMPTAKAFQLMTLLRGLGVNELTAPELTGEWEYKLSEMERGKISREEFMREIAQMTQVIVKRAKEYDNDTIPGDYATLKTPCPNCGSVVKENYRRFACTKCEFSMSKTPGSRQFEVAEVEELLTNKTIGPLQGFRSKMGRPFAAVLKISRDEEIKNYKLEFDFGQNDDENAEPVDFSDQTPLGPCPKCAGGVYEMPLSYVCENSVAKPKTCDFRSGRIILQQEILPEQMSKLLNEGKTDLLPGFVSQRTRRAFKAYLVRGKDGKTSFEFEPRKEKVPGKGKAAAVADDAEETTDAAPPKAAKKVAAKKPAAKKTVAKKKPAAKKTAA
(1144) DNA topoisomerase 1 [Anaeromyxobacter sp. Fw109-5]
1
MPRATKAAAAAEGVKAEGVKKEKAAPPKRAAKKVAQGGSLVIVESPAKAKTIKKYLGRSYDVRASVGHVKDLPKSKIGVDVEAGFTPQYDVIKGKAKVLSEIKRAARSAERVYLATDPDREGEAIAFHIAEELGDSGDGRVRRVLFNEITKNAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFKPEEYWTLEAELAAKLPPEFRARLSKVDGQKAELKEGAVTHALVKDLDGATYVVATVDKKERRRNAPPPFTTAKLQQEAANRLGFTAKKTMTLAQKLYEGVELGDEGAVGLITYMRTDSVRLSTEAVDAARGYIAEAYGQDHLPEAPNVYKTKAKAAQEAHEAVRPTSLEWTPARVAPFFEQIGERDMYRLYELIWNRFVACQMVPAVYDQTTADITAGRATFRATGSILKFPGYLAVYGAKPPEDEAGAEEEAKENGDREKANEERQLPPLEAGMILDLRRLLPEQHFTQPPPRFNESSLVKELEQRGIGRPSTYAAILENIQEKGYVEKVERNFKPTHLGLVVTDELVKSFPREMDLAFTAGMEERLDEIEEGNAAWQQVLKDFYDSFKDDLAKAEVNMRDVKRQEIATELTCEKCGKPMVIKWGRMGEFLACSGYPECRNTMNFKRGEDGTIVPEKEEDVPTDEKCPECGAAMVMKRGRFGRFLACTRYPECKGTKPVSIGVSCPKGCGGYISEKRSRRGKTFYGCSSYPGCDFVSWDRPRNEACPQCGSAYLLDKYSKKTGPYVACPNKECGYRRDAEAKAPGAASEA
(171) DNA topoisomerase [Leptothrix cholodnii SP-6]
5
MSKSLVIAEKPSVAQDIVRALTTTSGKFEKHAEHFENDHYVVSSAVGHLVEIRAPEEYDVKRGKWSFNNLPVVPPHFDLEPIDKSKGRLSALVKLIKRKDVTHLINACDAGREGELIFRLIEQYALGAKVGTKPVQRLWLQSMTPQAIRDGFEKLRSDAEMRGLAEAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSIVVEREEKIRKHVSRPYWEVRADFGAAAGLYEGKWFDPKFKKDDDLERRADRLWSEAEADAIAAAVRGRTGTVREEAKPSTQASPLLYDLTTLQREANGRFGFSAKTTLSIAQALYEKHKVLTYPRTDARALPEDYVPVAKETLAMIASEDLPGPLRELAQHARKALDAGYVKPVKRVFDNSKISDHFAIIPTLQAPRSLSEIEAKLYDMVVKRFIAVFYPSAEFMVTTRITEVPVAQSASQSLPKGVTSPLQFQTNGKVLVNPGWLAVYGKDAQDEDANLVPVKPGETVQAEELRISPLKTRPPARYNEATLLSAMEGAGKLIDDEELKAAMQEKGLGTPATRAQVIEGLILEKYMLREGRDLIATAKAFQLMTLLRGLAIEDLTKPELTGQWEYQLSQMEKGQLSRDAFMHGIADMAQRIVKKAKEYDRDTIPGDYATLKAPCPNCGGVVKENYRRFACVGRDANGSSGAEGSGCGFSISKIPGSRSFELHEAEAFLRDHKIGPLEGFRSKAGWPFTAELKLVRDDEINNWKLEFDFGEDAKKDDESGEPVDFSAQTSLGSCPKCKGHVYEHGTSYVCEHAVGAPQTCDFKTGKIILQQPVTHEQMNKLLIEGKTALLDGFVSNKTKRKFKAFLVFDKKEGKVVFEFEPRAARVPAKKAAAKAS
(694) DNA topoisomerase [Methylibium petroleiphilum PM1]
5
MACGTALRSGDNDIENMSKALVIAEKPSVAQDIVRALTPTSGKFEKHDDHFENEHYVVTSAVGHLVEIKAPEEYDVKRGKWSFAHLPVIPPHFDLAPIDKAKSRLNAVVKQVKRKDVGELINACDAGREGELIFRLIVQYAGTEKKPIDKPVRRLWLQSMTPQAIRDGFERLRSDADLRGLADAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSIVVEREEKIRKHVARDYWELKATFAAQAGEYEGKWFDPAWKKNDDAERRADRLWNEADAQAIAQAVRGQPATVTEESKPSTQSSPQLYDLTLLQREANSRFGFSAKTTLSIAQALYEKHKVLTYPRTDSKALPEDYVGVVKQTMEMLAAEDLPGPLKALSAHARKAVKEGYVKPNKRIFDNAKVSDHFAIIPTLQAPKSLTEVEAKLYDLVVKRFLAVFYPPAEFLVTTRISTVKAGSAEHRFQTHGKVMVKPGWLAVYGRDVEDADATLVPVEPGEVVRTESVDVNALKTKPPARYTEATLLSAMESAGKLIDDDELREAMQEKGLGTPATRAQTIEGLILEKYMHRDGRELIPTAKAFQLMTLLRGLQVEELTQPELTGNWEYQLAEMEKGKLSRDAFMREIAAMTQKIVAKAKEYDRDTIPGDYATLKTPCPKCGGVVKENYRRFTCAAKSGDAEGCGFSISKIPGGRSFELDEVESFIADKKIGPLEGFRSKAGWPFTAELKLAYDDEIANWKLEFDFGDDAKKGEGDGTPVDFSAQQSLGACPKCKGHVYEHGSSYVCEHAVGAHVTCDFKSGKIILQQPVAREQMTRLLQEGKTDLLENFVSNKTRRKFKARLAWDAKEGKVGFEFEPRAAKVPAKKSGVRAGTKS
(204) DNA topoisomerase [Methylibium petroleiphilum PM1]
4
MRVFLCEKPSQGKDIARVLGAGQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQYKRWAIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALGALKPSDETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVCVPFWAIEVALSHAGQSFVASWTPPQGSADDADRCLQQPVAQQAAEFLRAAGTAQVLSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLNSLVKTDPSLRPLIERLDRQQRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQFSCGSQSLAAVGKQIAVIGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLKALKTLPPKPYTQGELIKAMKTVAKLVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYLVKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMTLDTFIEKQSVWVGQLVQQYRGATLSLKLPPAPACPQCAAPMQQRTGKSGAFWSCSRYPDCKGTLPIESPTGRRSAPRKRRAASKAS
(1223) DNA topoisomerase [Burkholderia phytofirmans PsJN]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEDYEVKRGKWSFANLPVIPPHFDLNPIAKSESRLKVLTKLLKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTAGSIRDGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCSAGFYEGRWFDPKFKRDEFDPEKRDSRLWALPAAETIVAACRGQIGTVTEESKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKETLGMLKESNNYLPFAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVVGHHFKTEGKVLVEPGWLQVYGREISGEDANLVPVQKDEKVKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLIREGRDLIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACSKCEFSISKIPGGRQFEIPEVEELLQNKTIGPLSGFRSKMGRPFSAILKLSLDDEIKNYKLEFDFGQDAGGEDGEPPDFSDQQPVGACPKCKGRVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKEPSAKTAAKTAAAKSAAKAAPEAESDDGEVSVAVKAAPAAKKAAAKKAPATKTAAAKKAPAKKAAGRKTGS
(900) DNA topoisomerase 1 [Sphingobium sp. SYK-6]
1
MKLVIVESPAKAKTIEKYLGGDYRVLASYGHVRDLPPKDGSVDPEHGFAMAWENYGDKARQLKAITDEAKKADELILATDPDREGEAISWHVQEVLRAKKALPERVERVTFNAITKATITEAMKHPRALDDDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLIVEREREIEAFVSQEYWSVTALLEQGGQRFDARLVRWRGEKLDRLSIGKEGDALAAKADVEAGRFTVSSVETKPATRNPPPPFTTSTLQQEAARKLGLSASETMRVAQQLYEDGAITYMRTDGVQMDESAISAARNAIAKRYDGGYLPDKPRHYQTKAKNAQEAHEAIRPTDFSRESAGSGVHAKLYDLIFKRALASQMASARLERTAVELTDGTGQHVLRATGQVVLFPGFLALYEEGRDDPVGRQGAGDGEDEESRLLPALKAGDQPAKKDVRADQHFTQPPPRYSEASLVKRLEELGIGRPSTYASTIQTLKDRDYVRIEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEEELDEISGGRAQWQQVLEAFWRDFKPKTAEIMEQKPSEITAALDEYLAPMLFPDKGDGSDPRLCPLCHDGRLSLRGGRYGAFIACSNYPECRYTRKFGQPGGADGDAAGGNEELGTHPETGEPILRKSGRFGPYVEMGSGKEAKRASIPKDLPNGELTLDWATRLLSLPRTIGDHPETGKPITASLGRYGPYLAHDGKYARLASTAEIFETGMNAAVAKLADAANRGGARKAAEPLKILGAHPRTEAEIRLMEGRYGPYVTDGTTNATLPKTVAPDALTLEEAAQLIDERAAKAPAGKRKGKAKSSAGKSGAAKKTTVKGKAPSKAKSKAPAAAE
(138) DNA topoisomerase 1 [Sphingobium japonicum UT26S]
1
MQLVIVESPAKAKTIEKYLGGDFHVLASYGHIRDLPPKDGSVDPDNGFAMSWENYGDKGKQLKAIADEAKKATRLILATDPDREGEAISWHVQEVLRAKKALPQKVDRVTFNAITKQAVTEAMAQPRALDEDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIESFVPQEYWSVAAEMEQAGQGFTARLVKWRGEKIERLTIGREGDAMAAKADVEAGRFTVEKVETKPVSRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQQLYEDGAITYMRTDGVQMDGSAISAARKAIAERYDGGYLPEKPRQYQTKAKNAQEAHEAIRPTEFYRDKVGSGDHARLYDLIFKRALASQMASARLERTTVDLVDGTGQHGLRATGQVVIFPGFLALYEEGRDDPERGSGKHASADGEDDDSKLLPRMAAGDAPAKRKVTAEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASTLQVLKDRDYVRIEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEEELDDISGGRAQWQAVLEAFWRDFKPKTAEVMEQKPSDITAELDKFLEPMLFPPKADGSNPRACPMCGDGQLSLRGGRFGAFIACSNYPECKYTRKFGQPGGDKDGEDTGPEVLGQHPETGQDIVRKSGRFGPYIEMGEGKEAKRGSIPKDLPDGELTLDWAVKLLSLPREIGPHPETGKPIVANIGRFGPYLLHDGKYGRLSSTAEIFEVGMNSAVAKLADAANRGGRGASSREPLKVLGKHPRTEAEIKLMAGRYGPYVTDGTTNATLPKTIEQDALTLEEAAQLIDARAAAAPAKKGKKAVAKKAGAKKPAAKKAPAKKKVAAE
(1017) DNA topoisomerase 1 [Sphingopyxis alaskensis RB2256]
1
MQLVIVESPAKAKTIEKYLGRDFKVLASYGHVRDLPPKDGSVDPDDGFAMQWQLYPDKAKRLKEISDAAKGADRLILATDPDREGEAISWHVQELLRSKKALPAAVDRVTFNAITKQAVTDAMRHPRELDTDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIEAFVAQQYWSVTGLFEMGGTPFKARLSRWRGDKIERLSITSEADARAAEADVKAGHFTVDTVETKPLTRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQALYEDGAITYMRTDGVQMDGSAISAARKAIATRYDGGYVPDKPRQYQTKAKNAQEAHEAIRPTDFGKDKVGGGDHARLYELIWKRALASQMASARLERTSVELSDGTGKTTLRATGQVVKFPGFLALYDEGRDDAEDEDARLLPAMAKGDAPAKTGVEVERHETQPPPRYSEASLVKKMEELGIGRPSTYASILQVLKDRDYVRVEKNRFIPEESGRLLTAFLERFFERYVGYDFTAELEEELDDVSGGRAQWQAVLERFWRDFKPRTGEVMEQKPSEITAALDEFLGPYLFPDKSDGSDPRLCPNCGTGRLALRGGKFGPFIACSNYPDCKFTRKFAQSGGNGEADNGPETLGTDPESGLEVTKRSGRFGPYIQLGEGSEAKRSSIPKDIPAEDFDLDYALRLLSLPREVGVHPESGKPIMAGLGRYGPYLLHDGKYAKLGGTAEIFDIGMNAAVVRIAEAANGGGRGRAKAEPLNTFGPHPTSGGEMKLMEGRYGPYVTDGTTNATLPKTTDPATLTMEEAIALIDARAAKGPVKGKKKAAPKKKAAAKKAAAKEAPARKTAAE
(1736) DNA topoisomerase 1 [Desulfovibrio africanus str. Walvis Bay]
1
MAKNLIIVESPAKVKTIKKFLGRDYMVEASVGHVRDLPPNKIGVDEERGFTPDYKVIPGKQKVVAKLKAAADQAEHIYLAPDPDREGEAIAWHVAHLIGDKNKQVSRIQFNEITSRAVKEALDNPRPLDENLFHSQQARRILDRLVGYKLSPLLWSKVKRGISAGRVQSVALRIIVDRERERQAFRPEEYWVFKALLEGPEPPAFAAELWKVEGKKPSVGSGEQAQVLYDRVKDTPFVVSAIEEKERQRHPSPPFITSTLQQDASRRLGYTAKRTMSTAQRLYEGVELGESGVTALITYMRTDSVRVADEARDAAQAFIVETLGADYYPPKPRYFKTKSGAQDAHEAIRPVDVRVTPESVRKHLPADQYKLYTLIWQRFMASQMAAARLHDTTVTVDSGPAQWRAKGERVLFPGFLKVYGVDEATDEKTEGEGGESTSTKAAMLPKLEKGMQLTVRKLTKDQKFTQPPPRYTEASLVKELEEQGIGRPSTYAAIISTLLDRDYARLEEKKFVPSELGVTVVDLLTKHFQSLMDVHFTAGMEEQLDDVAGGKVNWVELLKHFTGDFYPTLDKAKDEMVQVKGGLETGIVCDLCGKPMNIRFGKNGEFLGCSGYPDCKGIKNFTRDEQGQIQIVERANEMPEKVGTCPDCGKDLVLKRSRTGSRFIACSGYPECKHAEPHSTGVTCPREGCTGQLVEKSSKRGKVFYSCSTYPKCNYATWDWPIAKPCPQCDSKILTIKTTKARGEHVACPEKACRFTRELEPDESVG
(262) DNA topoisomerase type IA central domain protein [Desulfovibrio salexigens DSM 2638]
3
MRLFIAEKRDVALAISQALGGPDRPTGAAFQVNGDRITWLWGHVLRLTDPEEHDERYKLWDLNTLPMKWPVTYAPESKHVDHLKKIIELAHQADELVNAGDPDPEGQRLVDEVIEFAGLLEKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAVCDQRYGYNLTRCYSTLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQIDMPSQLVEAEYIPADDAPVDEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPLPYNLLALQADAAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQALTPAFGDMAEYAAPNLKSKAFNSKKVTAHHAIIPTMNVPELGKLNEDERRIYTLIVKLYIAQFYLPAEFVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHKLQQNDSGTVESAESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDESGGIGTPATRDSHIETLFRRGFVAEKSKKVISTELGREFHDALPEFAVKPDMTALWHEKQKQIEAGELNYLQLIEEVDGSVAQEIARVKREGINIKSSAVQCPKCKTGFLKPRKGPKGKFWGCSAYPDCNATFPNKAGKPDLKAKPAKKLAASKEHKCPDCGKGLIRRPAKRKGLFWWSCSGFPECKFRCFDEKGKPKLES
(1384) DNA topoisomerase 1 [Desulfovibrio salexigens DSM 2638]
1
MSKDLIVVESPAKVKTISKFLGRNYQVAASVGHVRDLPKNKLGVEENGDFTPQYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIGWHVAAIIKEVNENVSRIQFNEITARAVKEALEHPQPLNEQLFDSQQARRILDRLVGYKISPILWKKVKRGISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWKVDGKKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDANRRLGYSAKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVILDKYGDEFYPAKPQVYKSKGGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNRFIASQMAPARFWDTVVTIQAKNTIWRSKGERLLFPGFMRVTGKTGDEKLIELPKLEKGEVLKVDKIESEQKFTQPPARYSEASLVRELEEKGIGRPSTYASIISTIQDRGYVNLEEKKFIPTELGFVVSDQLSEHFKELMDVGFTAAMEKQLDDVADGKIEWTSLMKDFVDGFYPTLETAAKEMKRGGEDTGITCDKCESPMVIKFGRTGEFLGCSNYPECKNIVNFTRDEKGKIVVLEEEPPEETGVTCEKCGSAMAIKRSNRGEFLGCTGYPDCRNIKNFERDDEGKIKVVETPTAQIVGKCPDCDDGDLIIKHARTGSRFIACSNYPDCKHAKPFSTGVKCPREGCKGELVEKSSRRGKLFYSCDQYPDCDYAVWYPPIDGPCPKCGHPVLVKKTTRAKGEHIACPEKGCGYVQGEEES
(24) DNA topoisomerase 1 [Desulfurivibrio alkaliphilus AHT2]
1
MGKSLIIVESPAKARTLQKHLGKDYLVKASVGHIRDLPVSSLGVDIDHDFAPQYVTIKGKAKVISDLKKAAKEADQVYLAPDPDREGEAIAYHIAEALKTTRKPIRRVLFHELTHKAVLAALEKSGEVDHHLFEAQQARRVLDRLVGYQISPLLWDKVRRGLSAGRVQSVAVRMVCEREEEIEKFVSEEYWSITTTLAGPQPPPFQALLEKVDGRKLDNRKRKIADEAQARELVLQLMAAELKVAGVDKKQQRRRPSPPFITSTMQMDANRKLRFSAKKTMAQAQRLYEGIDLGKEGPVGLITYMRTDSTRVNDEALGMARDYIGSTYGADYLPAKPVQYKTGKGAQDAHEAIRPTDVSRTPESLAGKLDKDMLALYTLIWKRFVASQMAPAIYDQTSIRIAGGPEGRHELKATGSIMRFPGFMTLYVEAVDETPEEGKQSGKGGKDALLPDLQEGQLLKLNEITPKQHFTQPPPRYTEATLVKALEENGVGRPSTYAAILSTIVDKEYVRLTQRKFYPTDLGRMVNKLLVAHFPKVIDTDFTAKLEQELDEIETGKVDWVQVMREFYGPFQQNLEQAREEMKAVKHSAIPTGLNCPQCESELVIKWGRKGEFLACSNYPECKHTQDFTRDEEGKIKPLEREAPEESGESCDKCGKPMVYKHGRFGKFLACSGYPDCKNVRAISTGVSCPEDGCDGEIVQKVSKRGKVFYSCNRYPKCTYALWDKPVAKPCPLCSSPFLVEKSSKKGRRLACPNKECRYSEELPEEGE
(1362) DNA topoisomerase [Desulfovibrio alaskensis G20]
7
MSKILIIAEKPSVAREIAPLVGAVSRRDGFLEGPTHIVSWAVGHLVNIAEPEEQDEAWGGRWALEQLPMIPRQFRLTVLPEARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRIQLHAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLAAFARAEADWLIGMNLSRLFTLKAGSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGGAAAAAGSAAPVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDVFSAVWHLPPDFKETRLERQDDAEAVIGRCQGGTGVVDATENRKGSQKPPLPFDLTTLQREANSRFGYSAKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHFRAVYHLYPQETVPAVERVKAGCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAPASFMSSTVRVLSGEDVFVARGKVFKDIGWLAVEPWRTAEDNPLPALRKGTRLHVHEVSAVRRQTKAPAHFTDASLLAAMETAGRLVDDEELRNAMKERGLGTPATRAQIIETLLARGYVEKKGKRLIATDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNTYPLFMQEIRTMLAQSVESIKPRNVKNILVETAARLASRELDGKCPLCGAEVEERDKGFGCSRWKRADGGCPFMIWRTFMGTQIDAGMVRELLETGCTSQELQLTSRGGNTFSARLRLEQGRVRPDLPEKHARASGGAAPSAGVDMHDPAENPFFADENPFPPEMP
(493) DNA topoisomerase 1 [Desulfovibrio alaskensis G20]
1
MGKDLIIVESPAKVKTIKKFLGNKYMVQASVGHIRDLPTKELGVDEENDFSPDYQVIQGKQKVVSALREAAAKADNVFLAPDPDREGEAIAWHVAEIIAKENKNISRIQFNEITARAVREALENPRELNRSLFDAQQARRVLDRLVGYKISPILWNKIKRGISAGRVQSVALRLIVDRERERYAFTSEEYWVFRANLAAETPPPFKAELFKVDDKKPAIASAEQAQELEKSIEGKAFIVDSVQEKERSRKPQPPFITSTLQQLASQRLGFSAKRTMSVAQRLYEGLDLGDMGTTALITYMRTDSVRISDEARDSARELIASLYGKEYCPAKAPVYKTKGSAQDAHEAIRPVDVTLTPDKIKGLVAPEQYSLYRLIWSRFMASQMAPARFHDTTVLIGCGGTQWRVKGERLLFPGYMAAAPASAKEANVELPPMQQGQTLELTLLEKEQKFTQPPARYSEASLVREMEEKGIGRPSTYASIISTIVDRDYTRLEEKHFVPTDLGFVVCDMLTNHFGTLMDIGFTAQMENSLDKVAEGDLDWVALMKDFTSDFNPTLASAAKEMKTVKAGLETDIVCSECGKPMAIKFGKAGPFLACTGYPDCKNTSNFTRDESGTIQLVEREQEELKPVGTCPECGKDLVVKQARTGSRFIACTGYPDCKHTEPFSTGVPCPNDGCDGQLVEKSSRRGKIFYSCNRYPQCDYATWNWPVAEACPQCDSKILTIKSTKARGKHIACPACKYTRALEDEE
(1757) DNA topoisomerase 1 [Sideroxydans lithotrophicus ES-1]
1
MATNLLIVESPAKAKTLKKYLGKDFEVLASYGHVRDLIPKTGAVDPDDNFAMKYETIARNAKHVDAIAKAAAEADHIFLAPDPDREGEAIAWHISELLKGKRALKGKTMQRVVFYEITQSAVREAVAHPREISIPLVNAQQARRALDYLVGFNLSPLLWRKIRPGLSAGRVQSPALRLIVERELEIEKFKSQEYWSVHLDSQKNSIPFKAKLYQFQGKRMEQLTIGSQAEYDAIHAKLVDAKLPPKVVRVEKKGKQRSPAAPFTTSTLQQEAVRKLGMTSDRTMRTAQSLYEGVDIGGQTIGLITYMRTDSVNLANEAVAEMREYIKDNFAGDYLPVKQPVYKSKSKNAQEAHEAIRPTSILRTPDSLRDHLNIDQMRLYEMIWKRTLASQMSPARFDTVSVDIRLSSDDTLFRASGQTLVFPGFIGVYMEDVDDAEEEDSAKLPPLVEGDVLPVDKLYGEQHFTQPPPRFSEASLVKALEEYGIGRPSTYATIISTLQAREYATLDKKRFMPTDVGRVVIKFLNEHFTRYVDYGFTANLEDELDDISEGKRDWIPVLNEFWKGFNKLISEKKDVDRPGTEILEETCPKCGKPLSKRLGKRGSFIGCTGYPECDYTRSLGGEEDAGESRKELGQHPDTNQLVLLLRGPYGPYVQLGEMIEGEKTKPKRVSWPKELPLEQADLPSALKLLSLPREVGAHPETGKKVIVNIGRFGPYIGHDGKFKSIPRTDSIFDIGLDRSVELLAQARSGGATVLRTLGEHPDDKAPIEVCSGRYGPYVRHGKINATLPKDVTPEAVTLEEALEMIAAKAAKGGTGKAKTTRKPAAKKAAAKPKTTKEKAAAKPKTTVKKATVKTATAKTTVRKVAAKPAAKKTTKK
(688) DNA topoisomerase [Candidatus Accumulibacter phosphatis clade IIA str. UW-1]
5
MSKKLIITEKPSVAADVARALGGFVRHDDYYEGDEYVLSSAIGHLLELACPEEYEVKRGKWSFAHLPVIPPHFALQPIAKTESRLKLLVRLIKRKDVAGLINACDAGREGELIFNYINQHAGNAKPVERLWLQSMTPQAIREGFSRLRSGTEMQGLGDAAVCRSESDWLVGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLALMVDREDRIRKFVARAYWELDGVFACAAGDYRGRWFDENFKGKDDDEHARADRLWDESRALALQNKCADQDGDVSEESKASTQLSPLLFDLTSLQREANGRFGFSAKATLGLAQALYEKHKILTYPRTDSRALPEDYRQTVLSTLSMLTGEGVGKGHDEQTLARYAPFAGRILASNWVVPNKRIFNNAKVSDHFAIIPTLQAPKHLSEPEMKLYDMVVKRFLAVFHPAAEYLITTRITRVAGEPFKTEGKVLVNPGWLAVYGREGQEGEEGNLVAVQAGERVHASEMLLSAHQTRPPARYSEASLLTAMEGAGKAMDDEELRAAMAGRGLGTPATRAQIIENLLAEQYLQREGRELQPTAKAFSLMTLLNGLGIPELTAPELTGEWEWKLARMERGELARTAFMKEIAAMTQRIVDRAKSYDSDTIPGDFGELSTPCPKCGALIKETYKKFQCQACDFSLWKIVAGRQFEASEIEELLTRRRIGPLSGFRNKMGRPFNAIIQLNADNSPEFDFGQGSAGADGPAEEVDFSQSETLGPCPKCGASVFEHGMAYVCERSQGSAKTCDFRSGKVILQQTVEAEQMQKLLSSGRTDLLRNFVSARTRRKFSAYLVRGADGKVGFEFEKREPRTPAKKSRATPTSEPSDAATPTSGTTTRSRKKASSS
(154) DNA topoisomerase 1 [Desulfovibrio magneticus RS-1]
1
MGKDLIIVESPAKVKTIKKFLGNAYAVEASVGHVRDLPSKKLGVDEKDDFAPQYQIIPGKQKVVSKLKEAAASASTIYLAPDPDREGEAIAWHVAQIVQEAGVPVHRIQFNEITAKAVREALSHPRDINEKLFLSQQARRILDRLVGYKVSPILWQKVKSGISAGRVQSVALRLVVDREKERRAFVPVEYWNFKARLAADSPPEFEAELAKYQGKKLEIGSAEAAAAAEAAITGQPFVVTAVTEKERKKSPPPPFITSTLQQAANQRLGYSAKRTMGAAQKLYEGLELGDSGTVALITYMRTDSTRIADEARDAAREYITEALGPDYYPEKARHFRSKAGAQDAHEAIRPIDVRITPADVKTLLPKDLFSLYKLIWERFVASQMAEARFWDTAVDVTAGPGLFKAKGQRLIFPGYLKVYGQEAGDEAKSLPKLDKGQELTLLELKKEQKFTQPPPRYTEASLVRELEEKGIGRPSTYAAIISTLIDRDYARLEEKHFVPSELGETVSDLLAEHFVKIMDVGFTAGMEEALDAVADGRTDWVNLLKDFTEDFNPTLAKAAKDMAKVKAGKETDVKCELCGKPMVIRFGKAGEFLGCSGYPDCKNTKEFDRAPDGAVIPRERKAEEVASVGACPTCGKDLVVKKSRTGSRFIACTGWPDCKYTKPLSTGVPCPKEGCSGTLVEKSSKRGKVFYACDAYPQCDFAVWDWPINEPCPQCDSKILVRKKTRDGELITCPSKSCRYKRAVGGKKDEGEGEE
(1863) DNA topoisomerase 1 [Campylobacter lari RM2100]
1
MKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDENFKPEYRISSDHSTLVKELKEKAKNAKQIYLATDEDREGEAIAYHIAKAINKDENSLPRIVFHEITKSAIENALNNPRHLDINSVNAQQARRLLDRIVGYKLSPLLNQKIQKGLSAGRVQSAALKIIVDREREIKAFTPLKYFSIDVIFKKDLEAELVEFQGQKIEKFTITNEDRAKLIFENCKNAKFKINNIESKDRKITPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVKTHQGIMGVITYMRTDSLNIAKEALEQVRKLIKDEFGKEYLPAKANIYTTKAKGAQEAHEAIRPTNLSFTPKLASEFLEKDEARLYTLIYNRFLASQMNPAISQTQNVYAKSNEASFKISGRKILFDGHYKVYGDMDKDKILPNLKLEDTLNIQNIEFNSHFTEPPSRYSEAGLVKKLENLGIGRPSTYAPTISLLSARDYVRIDKKQLIPNEIAFNVIEVLEQNFSDIVDSDFTFKMEESLDEIAEGKLDWQELLREFYFPFMRKIDEGKKNIKSQKTITKIDETCPDCGGELAIRKGRYGEFIACLNFPKCKYSRNLKQENKNEEKTQIKQVNSIGLTCPECKKGEIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGENLIIKELKKGTFLECLKCKIKKEI
(553) DNA topoisomerase 1 [Desulfomicrobium baculatum DSM 4028]
1
MGKDLIIVESPAKIKTIKKFLGGGYEVEASVGHVRDLPTKTLGVDEGNDFAPDYQIIPGKAKVVSKLKSAAKAADTVYLAPDPDREGEAIAWHVAEVIRTSNPNVKRIQFNEITAKAVKEALANPTELRKPLFDSQQARRILDRLVGYKISPLLWKKVKRGLSAGRVQSVALRLIVDRERERQAFVSEEYWVFKITVQGETPPPFDADLWKVDGEKPVIGDEKTALALESRVDGQSYVVRDIVEKERQRHPRPPFITSTLQQDASNKLGFNAKRTMSVAQRLYEGVELGERGTTALITYMRTDSVRISDEAKDGAREWITRTLGPEFYPKEPRVYKSKGSAQDAHEAIRPVDPSLTPDSIKNNLPPEQYKLYRLIWERFMASQMASARFWDTVATIESGPAQWRAKGERLVFPGFLQIWPQSSDNQSALLPKLVTGQELRLEKLHKEQKFTQPPARFSEASLVHKLEELGIGRPSTYAAIISTLTERDYVHIEEKHFQPTDLGVIVCDLLVEHFAHLMDAGFTARMEESLDHVAEGETDWVALLRDFTLDFNPTLDKARENMTQVKAGMDTGLSCPQCEDGRLVVKFGKNGTFLGCANYPACSFTSNYIRNNAGEIELVKEEAPEELGPCPKCEDGRLVVKKTKTGGRFVACSNYPACRHTKSVSTGVACPKDGCDGELVEKTSRRGKPFYSCSKYPKCDYAVWDFPVAKPCPLCESKILVRKETKARGAHLACPVKDCGYWEKLD
(1398) DNA topoisomerase [Desulfomicrobium baculatum DSM 4028]
7
MPRTLIIAEKPSVARELAGVLGVKGRGDGFLQGPGHIVTWAVGHLVNIAEPAEQNPAWSGRWSMRQLPMLPSRFTLGILPSTAKQYEIIRNFLLDDDIDSVVNATDAGREGELIFRRIYLLAGSTKPIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAAFARAEADWLVGMNFSRLFTLRAGSLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGEFAHEGETFKATWFAAPDFKDSKIWQVEEGQTVVQACAGKDGAVLEMEKKKGRQKPPLLFDLTNLQKEANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVYAHFPEISQSAAANIKDAKKKFECVNDKKVSDHHAIIPTTLRANPATLGKEEWAIYEMICRRFAAAFMDDATFASSTLWIGVEGHRYRATGKIFQDKGWLEAEPWRASEDNPLPNLRKGAAVTAQSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKERGLGTPATRAQIIETLLARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVASPELTGEWEKRLKEMEQGGYAYGVFMHQVREMVSSGVSRVKGSNARPPACPVVSDRKPSKEVNS
(1558) DNA topoisomerase 1 [Bdellovibrio bacteriovorus HD100]
1
MAKKSDATDGIKLVIVESPTKAKTIRKFLGRDYVVESCMGHIRDLPQSAKDIPEKVKKEKWAQLGVNVDKNFEPLYCVPKDKTKVVKNLKDKLEEASELYLATDEDREGESISWHLLEVLKPKVPTKRMVFHEITKDAIQKALKDTREIDFNLVRAQEARRVLDRLVGYTISPLLWKKVAYGLSAGRVQSVAVRLIVERELERVRFKKSSYWGVLAELSKDGVSFESRLQQYKNQRVATGKDFDGLTGQLTAGKDVLVLDEKTAGKLSMDLKSGNWQVTDVEEKPTFRKPAPPFITSTLQQESNRKLGLSSRETMQVAQKLYEQGFITYMRTDSTFLSNEAITASRDCIESKYGKEYLTPQPRNYAAKKVKGAQEAHEAIRPAGNQFMDPDETGLTGTQFRLYDLIWKRTIASQMVDARQKQVSAKITVGDALFGASGMTIEFPGFLRAYVEGSDDPEADLAEREVRLPALKVKDGVKCAKLDPTSHETKPPARYTEASLVQTMEKEGIGRPSTYASVIGTIIDRGYVRKNGTALVPTFTAMIVSKLLSQYLSQYVDLGFTSEMEQSLDNIADGELDWESYLASVYKGPKGLRAMVDNQGDKIDPNEARTMTLEGMDKYKFHVGRYGAYVTTQRDGEDVSASLPDNESPADITPEIAEKLIDQKINGADSLGNDPETDLPVYVLNGRYGPYVQLGDVTPEDDKPKRASLPPGTQPEQVDLAMALSLLQLPKTLGTHPGTGKDIKAGLGRFGPFVVHDGDYRSIPKGESIFNITFEKAMEMLAQPKKGRGRAAPLKELGAHPDSGDAIQVFNGPYGPYIKCGKVNASLPEGATPDTVTLEQAVALINEKGPAKGKGKAKGKAKAAPKAKAAKADGEKPAAKKPALKKAANAKEKAEALGVKKVVTRKSKK
(1499) DNA topoisomerase 1 [Bacteriovorax marinus SJ]
1
MKRASPFHLNKDVIMASSEAVEETKSSKKTAKKTAKASSKKKTTKKKTTTSKKKTAKKKTAKTTKKKTTKKRDLGDYSLVIVESPSKAKTIKKYLGKGYQVVASNGHIKDLPKSKLGVDIKENFQIDLVPITGKKDKIERIQELAKDATAIYLAPDMDREGEAIAHHLAEEIGKKKKMYRVVFNAVTKSAVNNAIENPTELNKSMYESQQTRRILDRLVGYKISPILWDKVQRGISAGRVQSVALRIIVEREDEINAFEPEQWFSIHGVCEKDAQKFEVKYYGESATKKTDLTEKDLVDKILSDVKGKSLDVIDVKKKERKQNPTPPFTTSKLQQEAANKLGFTAKRTMMTAQKLYEGIQLTEHGMQGLITYMRTDSVRTAPEAMGALREFILDKYGKDYLSVEPIEYKKKGSSKVQDAHEAIRPTNLAFTPDSVRGDLEPDQQKLYELIWNKFISSQMSQAIIDQTTVMMEREGHFFKANGSIIKFPGFRTVYLEAAAEKRSRKGGDDEDDNDAGEVKSGLLPVINTGESFTPIEGPTEQEHWTSPPPRFNEASLVKSLEEFGIGRPSTYAAIISNIQDRGYVEKTENRFLPTELGIVVCRMLVESFPNVMDIKFTAGVEELLDQIEDGTIKYKKVLKEFWKEFEVTLEKAKEEMKNLKKQLIPTGINCLKCEDGEYHIKWGRNGQFFACSNYPDCNSTQDFKKHLDGSYEILPKNWFHDNCPNCQKRLEVKKGKYGRFVRCEDYPQCDTTLPYTLDITCPECNVGKFAEKKSRYGKIFYGCSNYPNCENASWTKPYVQDCPSCGYGIMGFKETKRDGKHLECAKCKFKLEWEQTKYGKEELEKQRQEEEALKGSH
(1533) DNA topoisomerase 1 [Geobacter daltonii FRC-32]
1
MPQHLVIVESPAKAKTIEKFLGPDYKVLASFGHVRALPSKQGSVDIEHDFEPKYAVLPESKKHIDAIKKELKQADVLLLATDPDREGEAISWHLLAALGLDKKPNIDIKRVVFHEITKGAIVNAVENPRGISHELVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFVEQEYWTIGADLSTAGKQNFTANLVEADGKKLGKFDIPGKEAADKLIEILDKATYSVEKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSIAQKLYEGIDIGEGTIGLITYMRTDSVVLSQQALDEAHQVITSLYGKEYALAKPRVFKNKAKNAQEAHEAIRPTYISKTPVELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVEISAGKGYKFRVAGTVIRFPGFMKLYIEGVDDETEEKEGVLPPLNEGDSLQLRDLLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYARLDKKRFFPEDVGMVVSELLVNHFTKYVDYNFTASLEEELDQVSRGEKKWKPLLHEFWQPFHNLLKQKEGEVNKSDLTTEATDEICPECGKPLVVKLGKFGKFFACSGYPECKYIRPLDKDKKESAEPVFSEEKCEKCGSQMLIKEGRFGKYLACSAYPACKNMQPLVKPKGTGIKCVECGEGELTEKKSRYGKMFYSCNRYPQCKFALWDLPVEKPCPKCGFPLLVKKVYKREGEFLKCPKDGCDYKEGGKEK
(1416) DNA topoisomerase 1 [Desulfococcus oleovorans Hxd3]
1
MNKPVIIVESPTKVKTITKYTGNAYSVTATSGHLRDLPPHELGIDIDNGFAPDYVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIAFHVADLLKKKGRRFHRVMFHELTKTGIQKGLTEPTELNRNRYDAQQARRILDRLVGYQISPLLWRKVRNGLSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVKKGTKNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAIRKLGFTAKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPEAAHEALAHIRSVFGNDYAPDRPRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKRFVASQMSEAQIDQKTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDKLPQLDEKEVLKLIELDPKQHFTTPPPRFSEASLVKELEENGIGRPSTYATILSTIRDKGYVDLINKAFRPTELGFIVNDLLVENFPTILDIEFTANMENDLDRIESDQLQAVRLLERFYGPFSQRIEAAKDRMRSVKGVGMDTGLSCPECGKELKIKLGKNGPFLACSGYPDCKFSRNYARTDKGTVEPVEPDLTVAEGKSCEKCGSPMVVKQGRYGDFLACSAYPDCKSTQSLNSGANAAPIGVKCPEPGCNGDIVEKKSKRGKVFYGCSRFPKCTFASWDKPVDMACPDCGAPFVVEKTTKKEGTVLTCASEGCGFRQRT
(72) DNA topoisomerase [Desulfobulbus propionicus DSM 2032]
7
MGKTLIIAEKPSVAADIVKALPGKFTNAKTHYESDEYIVSYAIGHLVSIAYPEEINPELNKWTLDNLPILPEEFPLAVLPDTKAQFNALTKLIRRRDVEVIVNGCDAGREGELIFKYILKQATNRSVEHKRVQRLWLQSMTLDAIRDGLGKLKDDQEMRPLEDTALCRSEADWLIGINATRALTCYNSRFGGFRKTPCGRVQTPTLSLLVKRETERREFVPTTYWELHGCFVCGPVAYQGVWIDPAFAKDEEQAHGRRNRIWEEERAKEIADRCTGKPAMVEESSKKSTKGAPPLYDLTLLQREANSRFGFSAKNTLALAQALYERHKLITYPRTDSRCLPEDYLPTVVKVVGQQQQWQYGRFASEALEKKYLKKDKRIFDNKKISDHFAIIPTAGLPKTLSEPELKIYQMIVQRFLAVFFPAAVYHNTRRLSLVEGETFLTEGKILVEPGWRAIYGASSEEDGDKELQALPPDTLVQCEDIDRQEHQTKPPPRFTEATLLSAMEHSGKLVEDEELAEAMKERGLGTPATRAAIIEKLINEKYIVREQRELVPTGKAFELLSLLEARKIDVLASPELTGEWEYKLNQILKGAMTRTQFMKEIREMTGAIVDKVKQGGGTERHEAPFSPVDGARFYETASAYESEDKKLIIRKVLGGRVMDPAEIVELIRGKTLGPFNDFRSKKGKPFTASVHIANSKVEFLFADSTDELNLDEIRGQEPLGLSPVDQTKVFETPAGFLSESALEGDQKKGLRISKIILGKKLEREHISQLLADGRTELIGGFISKRKKPFDAFLLLDAKGKLSFAFPPRGKKGKDKEADNG
(1500) DNA topoisomerase 1 [Syntrophobacter fumaroxidans MPOB]
1
MSKSLLIVESPTKAKTLGRYLGKDFIVKASVGHVKDLPKNRLGINLEKDFQPEYQVIRGKKKVISELHEAAAKSGAIFLGPDPDREGEAIAWHIAEEIGATDKPVYRVLFYELTRKAIQEALAKPDRLNRELYEAQQARRILDRLVGYMISPILWQKVKRGLSAGRVQSVALRLICAREKEIRDFDSREYWTITALLGTQASADAPAKSASRRFKAELFRCGKKKCTISTGEEARELVDRLRPLDYRVSKVERRKKKRHPAPPFITSTLQQEAARKLHFSARQTMNVAQRLYEGLELGKEGAVGLITYMRTDSTRLSADAVQAVRDYIAGHWDKAYLPAKPAAYKSKAGAQGAHEAIRPTDVNRTPETVAGFLTKEQLKLYTLIWKRFTACQMAPAVLDQTSVDIAAGDYVLRASGSIVEFPGFMTLYVEGRENGDEDSETEGLLPELKEGEVLRLEDLKADQHFTQPPPRYTEASLIKELEDLGIGRPSTYATILSTILDREYAVVRKKSLFPSELGWLIDGLMVENFPSVVDVDFTAKMEKSLDEIEQGQHPYRNLLAEFYEQFSKTLESARTNMVNLKAVGRRTDLQCPQCGLPLHIRWSRNGPFLACSGYPDCRFSSDYRRDEKGNIEPVAEESTGETCEKCGRPMILKKGRFGNFLACSGYPACKNTKAPGTGIPCPREGCSGELVERVSRGGRHFFGCSRYPECKTAFSGRPVPGKCPSCGTGPLIEKGGKGGSVKRVCVNPSCKYVETVPAAADRKAAKD
(61) DNA topoisomerase 1 [Lawsonia intracellularis PHE/MN1-00]
1
MGKNLIIVESPAKVKTIKKFLGSGYVVQSSVGHIRDLPKKNIGVDESKNFSPHYEIIPGKEKIVQGLRETAAKVDTVYLAPDPDREGEAIAWHVAELIKDKNSNIQRIQFNEITSKAVQEALSHPQKLNKNLFDAQQARRILDRLVGYKISPLLWKKVKQGISAGRVQSVALRLIVERDEERYTFIPEEYWLFKANLEGSNPPPFKVELWKVNNKKPIIPDAVTAAALEQQIKDKPFIVDSIEEKERQRSPKPPFITSTLQQAANQRLGYTAKRTMNIAQRLYEGLELGDKGTTALITYMRTDSVRIANEAKLAAATLIEQKFGKEYLAKGGNGRNFKGKAGIQDAHEAIRPIDVTILPEDVKPYLAPDQYQIYRLIWSRFIASQMSVAQFHDTIITINCENSQWRTKGERLLFPGFLAAFPNTKEEEDTNLPVLHKGEILKLHSLIKEQKFTQPPPQFTEASLVRELEELGIGRPSTYASIISTLQDRDYVRLEDKHFIATDLGRVVCMLLQDYFKNLMDVTFTAHMEELLDKVAEGKQDWVELLQNFSETFNPTLEEATKAMSQVKTGLETDINCPDCKKPLVIKFGKSGQFLACSGYPQCKFTSNYLRDDKGQIHLQEKVQPELQKIGICPKCNKDLVLKKARTGSRFIACSGYPECNYTEAFSTNVPCPCEGCKGMLVEKSSKKGKVFYACNTYPTCDYAIWNWPIQKSCPTCSFPILVEKITKAKGKHLACPEKNCRYTCELEESDIET
(409) DNA topoisomerase 1 [Sulfurovum sp. NBC37-1]
1
MKNLIIVESPAKARTITSFLGKDYKVIASKGHIRDLPKSTFGITIDDETGDLIPKYSIPRDANPTVKELKKLAKEAETIYIATDEDREGEAIGYHIAKAIGKEPTELPRIVFHEITKSAIQHALENPRKVDMDSVDAQQTRRLLDRIVGYKLSPLLASKIQKGLSAGRVQSSTLKIVVDREREIKAFKPEEYWTIDALFEKNIDASIYDYNGLKIDKLTIKTDADANEIVESAKGESFVVSSIEKTKRKTKTPPPFMTSTLQQAASTQLGFSPKKTMMVAQKLYEGVKTDKGTMGIITYMRTDSLNLAKEAVEAARTHIKETYGDKYLPAKAKHYTSKSKGAQEAHEAIRPTRVDFDGTKAANFLNADELKLYRLIYNRFLACQMTEAELESQTILFKGDKCTFKASGRKLLFDGFYRVTGYNEKDKLLPELKKEQPVSLDDIKAEQHFTEPPARYNEASLIKKLESLGIGRPSTYAPTITILQTRKYIEIEKKRIHPTEIAFTVIEMLEKHFPEIVDSGFTANMEETLDKVAEGETDWQTILKEFYTPFLQKIEEGKKNIKSLKVAIPTGENCPKCGSELLLRKGRYGEFIACSNFPKCKYTKNTDGTEVEQPEETDEKCEKCGSPMVIKNSKRGKFLACSAYPKCKNAKSLTPPKELSVPCPECGGKLQEREGRRGKFFGCENYPKCKFIANFEPVDKKCPECGYTMGKKTLRGKEIFECFKCKHKEEAK
(309) DNA topoisomerase 1 [Pelobacter propionicus DSM 2379]
1
MPQNLVIVESPAKAKTIEKFLGKDYKVLASFGHVRALPSKQGSVDIEQDFTPKYHILPESKKHIDAIKAALKDAKNLLLATDPDREGEAISWHLLAALGLDKKNPGKSIQRVVFHEITKDAIIHAVENPRDIATDLVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFKEQEYWTIAARLGVKPGAEFRASLVEVGGKKLGKFDIPDENVATALNRALKSGSYRVAKITRTERKRNPSPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGIDIGQEGTVGLITYMRTDSVTLSSQALTEAHEVISAAYGAEYALAKPRIFKTKTKNAQEAHEAVRPTSIARTPAELKKHLTPDLFKLYELIWKRTVASQMAEALLDQTSVDIAAELNEAVADCTVAESGAASPFTGAKRCGLRAAGTVIRFPGFMKLYIEGLDDQDEEKEGLLPPLQEGDDLKLHELFPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYTRLDKKRFFPEDVGMVVNDLLVAHFSRYVDYNFTAGLEEELDQVSRGEKQWKPLLKEFWEPFITLLKQKEGEVKKDDLTTTELDEVCPECGKPLAIKLGKRGKFIACTGFKEGCTYTRNLESDASEPSEPVLSDEKCDKCGQQMLIKDGRYGKYLACSGYPACKNIQPLVKPRGTGVVCPECKEGELTEKKSRFGKLFYSCNRYPQCKFALWDPPVEQPCPKCGFPLLVKKVYKRKGEFLKCPKEGCDYTSE
(426) DNA topoisomerase 1 [Desulfatibacillum alkenivorans AK-01]
1
MSKPLVIVESPTKVRTVKKYLGNDYNVAATVGHVRDLPQKNIGIDIDNNFEPQYEVIPGKQKVISNLKKLAKDASEIYLAPDPDREGEAIAWHTAQLLQGKNRRFHRVLFHELTKNAILNSMQNPLELDKSKFEAQQIRRILDRLVGYQVSPLLWKKVQRGLSAGRVQTVAVRMICEREREIQAFDPEEYWSITAHLQKDEPPVFPAKLLKIGDKKAKVSNEEEANAVLKELEGETYVVDRVIKKTVKRNPLPPFTTSKLQQDSIHKLRFSAKKTMLLAQQLYEGIDLGPGEPVGLITYMRTDSTRVSNEAALEALDYIGKVYGPEYRPDKPRFFQNKKKVQDAHEAIRPTNVLRTPNQVSDVLSKDQLALYTLIWQRFVASQMNPALFDQTSVSVKAGRYLFHATGSTLKFKGYLMVYDAGDGDKDDNKIMLPVLEEKMILQCNKLEPKQHFTQPPPRFSEASLVKELEENGIGRPSTYAAILSTIRDKGYVDLVKRYFRPSELGFIVNDLLVSSFGDIFEVPFTAQMEDNLDKVETSQANSLEILNAFYNSFKQDLENAGDKMVSVKGVGVPTGIKCPQCEKELHIKIGKNGPFLACSGYPECRFTRNYDRDDKGGIVMETPPETEETDEVCDKCGKPMLVKSGPYGTFLGCSGYPDCKNTKTMNGGAQQNQATGIKCPVEGCDGEIHERRSKRGKVFYGCSKYPKCDFATWDKPVDKPCPVCQSPYLVEKSTKKSGVYLKCPTRGCKYREDPQ
(497) DNA topoisomerase 1 [Geobacter bemidjiensis Bem]
1
MSQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPESKKHIDAIKKEMKGISSLLLATDPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITKDAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKLGGKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQLLPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFTQYVDYNFTANLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVNKSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEEICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFGKLFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS
(359) DNA topoisomerase 1 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]
1
MKKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKNPRKLNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDREKEIRAFVPLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSISDIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIAAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGRKILFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISILTSRDYVTIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIAEDKADWQETLKEFYYPFMRKIEEGKTKIASQKTVTKLGESCPDCGGELAIRKGRFGEFVACLNFPKCKYSRNLKSESKNESENTAAKAKANGTGITCPSCQKGEIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGETLVIKELKKGTFLECLKCKIKKEMKD
(123) DNA topoisomerase 1 [Campylobacter concisus 13826]
1
MKSLIIVESPAKAKTIKNFLDKSYNVIASKGHIRDLPKTSFGIKIEDDKFTPEYRISSDHSAIVKEIKELAKGADEIYLATDEDREGEAIAFHIANAIGKEPTSLPRIVFHEITKSAIQNALKSPRHVDMNSVNAQQTRRLLDRIVGYKLSPLLNLKIQKGLSAGRVQSAALKIIVDREREIQAFKPVEYYTIDTVFKKDLDAELVKFENQKIEKLTIQNPDRAKYIIENLQNEKFSVREIESKDRKIQPSPPFMTSTLQQSASNRLGFSPKKTMMIAQSLYEGVQTNEGFMGAITYMRTDSLNLAKEAVAAAREHILQNYGKEYLPAKAISYTTSSKGAQEAHEAIRPTNLNFTPQIAAKFLEKDALKLYTLIYNRFLACQMSACVSQTQNVYVASEKGEFKISGRKVLFDGFYKVYGELDKDKILPNLKKGDEMSLQSIKSTQNFTEPPARYSEAGLVKKLESLGIGRPSTYAPTISLLTSRDYVRIEKKQLIPNEIAFSMIGVLEEHFSNIVDSEFTSHLEEKLDEIALDKADWQKVLSDFYYPFMEKISAGKTGIKSLKTATPIGEKCPECGSELVLRKGRYGEFIACSNFPKCKYSRNVAKDNEKSAETGSTTAAKPKRELKKLDVPCPKCGGEIVERFSRRGKFYGCANYPKCDFISNYEPVAQKCDECGGDMIKKELKKGTFIECTKCKKKTLVSEN
(596) Reverse gyrase [Nautilia profundicola AmH]
6
MLHIIYKNECPRCGGDISSVNLNKGMFCDECMKSKKKEWNLENCENLLNYEKYCIADKKVNEFNEFFKFKCGNELNSIQKMWAKRFFLDNSFALLASTGIGKTTFGLLLSAFVKNSYILFPTKLLVAQAAEKYKKWGIEFVAYMGKKSEKELIEKGEYDILITTTQFLYKNRSLIKRNFELIFVDDVDSILKSGKKIADILTLLGIDKNSIEKTYELIKNQKYSEIKSVSKKGNLIVSSATANPKSKKILLFKYLLGFEVSRPNFNLRNIEDLYDENYSWDHSVKWINELGRGGLLFLPGNETKDTLYEYIDFLNTKNIKAYSYEDFEKHLEEFKEGKCFFVGFASYKNPLARGIDLPEYIKYTLFVGVPKIEFNLKDENFRAFYFIMLSLLPYLVKNNLSQKEVSEIQNDLNYLKKYIYLSKINVNTQQKIADILIRFKNTVKKYEDIIKTAENISFDGEKFIIADVTGYIQASGRSSRFYKGHLTKGLSLLLVDNKKAFYSLKKKLKWFGEIEFKNVEDVDIKKVLTEIEKSRTENVKTEFKTSFVIVESPTKAKTISSFFGNPSKRIINNVAVYEVLSQDRVLIIAASIGHDFDLVKDEGVWGVKDLIPIFHVLENKDKILQTLNINANEVEEVYAATDPDREGEKIAFDLTMINKPYNMNIKRIEFHEITKQAFEEALSIPREIDLNLVKSQLFRRITDRWVGFKISLYLQRLLNNTHLSAGRVQTPVLKWICERTGLLKEKIYVVIIRFNNVSIDFEFDTKQEANEFFNSLKESVYIKKLSSNTEVMFEKPFNTPDLLKEASNKLRFSPQKTMQLAQELFEKGFITYHRTDSYRISDTGKAIAKTYILENFSKDYLKFRNFESKGAHEAIRATTSMDADELRSYMLERNILLSEEHLRLYDLIFRKFIASQMKEAKVLKEKFLILLKEKSFITEIVENGYNLIYPINIYIISEGENKIVKELRQKPKAAPYTYAEVIEEMRSKGIGRPSTYAIIIEKLLKRKYITDKNGYLFATKLGFRIIKEVYKSDFKDFVSEEFTAELENIMDKIEEGKTEYEKELKKLFSLLF
(705) DNA topoisomerase 1 [Nautilia profundicola AmH]
1
MAKNLIIVESPAKARTIKNFLGKEYEVVASKGHIRDLPKTSFGIKIEEDKFIPQYRVTADHQPIAKELKEKAKKAETIYIATDEDREGEAIGYHIAHVIGKKPEELPRIVFHEITKTAIKKALENPRTIDLNRVNAQQARRLLDRIVGYKLSPLLNKKIQKGLSAGRVQSAALKLVVDREREIKAFKPQEYWSIEGIFKKIEGSLIKYNGKKLDKFDIKSKDEAQKIVEELKPLEYTVREIETKTTTVKSPAPFMTSTLQQVASSELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQQAALEFIKQNIGEEYAQAKTYATKNQNAQEAHEAIRPVDVRLTPDDLKNYLKPDELKLYALIFNRFLASQMKDAKFETQNIYIANDKGEFKISGRKLIFDGFYKVYGKPSANTLLPEFEKGEKLKPEDVKATQHFTKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEVKDKKLHPTEIAFSVIETLEKHFPDIVDANFTANMEEMLDEVAEAKKDWQEVLKDFYNPFMELVNKGYKEIPSQKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYPKCKYTRPLEESKEEKKTDVKCDKCGADMVVKKGKSGEFLACSNYPKCKNTKPLNAPEVLDDVKCPECGGDIVKRKSRRGEFYGCANYPKCNFISKYRPVNKKCPECGYLMAERTYRKKDVYECIKCKHREEAKK
(997) DNA topoisomerase 1 [Sulfuricurvum kujiense DSM 16994]
1
MKLIIVESPAKAKTIKNFLSKDYEVIASKGHIRDLPKNRFGIKIDDEKIIAEYRISEDSTATVKQIQELAKKSDTIYIATDEDREGEAIGWHIAHAIDKDPSSLPRIVFHEITKNAIIHALETPRTIDMDRVNAQQARRLLDRIVGYKLSPLLANKIQKGLSAGRVQSSTLKIVVDREREIRAFIPEEYWTIDTLFKKDIEAALVNFENEKIDKLTIKTGDEAARIVETLKGESFKVGEIETKERKSSTPPPFMTSTLQQTASSQLGFSPKKTMMVAQALYEGVKTPEGTSGVITYMRTDSLNLATEAVEAAREVILTRYGKEYLPKEAKVYTKKSKGAQEAHEAIRPTMLGFTPEVAATYLKPDEIKLYRLIYNRFLACQMNDARFEQQSITFESAKAQFRATGRKLLFDGFYRVTGSDDKDKLLPSLTTGDSIEIQTVTPEQHFTEPPARYSEASLIKKLESEGIGRPSTYAPTISTLQARNYIEIEKRAIMPTEIAFTVTEMLENHFNEIVDASFTATMEETLDEISESGKSWHKILLDFYYPFIEKIDAGKSNIVSLKMAKPLGRNCPQCGSELLLRSGRFGEFIACSGFPKCKYTEQTEENQKENPATPDEVSEEVCDKCGSAMVVKNGRNGKFLACSGYPKCKNTKTLNQETKFSQVPCPECGGKLLWRQSRRGAFWGCEHYPKCKFISKFEPSDKKCEVPGCGGALAPRTYRNKEVYECVKCKDRTPREEAGE
(572) DNA topoisomerase 1 [Arcobacter sp. L]
1
MASMGHVRDLPKSSLGFDPSDNFKPKYMVTADKKKVISDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAILKALENPRDVDQHLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFVPEEYWKVKADFINPELKAELAKISAKTAKVDNEEQALNIESSLNQGIYKLASIEEKESIRNPAAPFTTSTLQQEASRKLGLSVKQTMVIAQQLYEGNVGNIPNHTGGLITYMRTDSLNLSTVATSAAKAVIEEEYGKEYSLSKPRVYKSTAKGAQEAHEAIRPVNLALKPSMIKEFVEPAQYKLYSLIWKRTLATQMAQAKIANTTYKIEAGRDKEFEFQSKGQRIIFAGFMKAYTEGSDNPEAALDSTEKILPNIKVGTVLELEKLESEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYVTKTEDKKLIPTQTGEIVNSFLVDHFSDIVDLGFTAKIEEEFDEIALGKIAWEQVMKDFYGNFKKTIDEKEESVHKEDYLQSREIGIDPKSGKPVSARVGRFGPFIQIGTKDDEEKPKFVAIPDNLNMDTITLDEALFLFTLPRVVGLDNSGDEIKANIGRFGPYLQVKTKFYSLKTDDPYTVDLNRALEIIKETDEAKEKSTIKTFDKEKIQILIGQYGPYIKQGRKNFKIPKSVEAKDLTLEQCLEIIAKDSKTKTSSTKKASTEKKASTEKKETKKKTTTAKKTTKKSADK
(1699) DNA topoisomerase 1 [Sulfurimonas autotrophica DSM 16294]
1
MNLIIVESPAKAKTIKNFLGKDYDVIASKGHIRDLPKSRFGITLDEETHELVPKYSVAKENAPTVKEIKEKAKKADTIYIATDEDREGEAIGWHIAHAIKKDPLELPRIVFHEITKTAIKHALESARKIDMDMVNAQQARRLLDRIVGYKLSPLLASKIQKGLSGGRVQSSTLKLVVDREREIKAFVPQEYWSIDTVFKTNIDANLIKHKDKKLSKLSIENKEQAETITQSVKNDNFTIAKIETKQRKSSTPPPFMTSTLQQTASSKLGFTPKKTMMIAQTLYEGVKTPDGTSGVITYMRTDSLNLAQEAVGAVRGIIENRYGKKYLPKEPKIYTKKAKGAQEAHEAIRPTMLQFTPEVAQSFLKADEIKLYRLIYERFMACQMEDAIFEQQSIIFKGNENEFRASGRKLIFDGFYAVTGTEDKDKLLPTLKEGEKAEIQSVKPEQHFTEPPSRYSEASLIKKLEAEGVGRPSTYAPTIATLSNRTYVTIEKKQIIPTEIAFTVTEILEKNFPNIVDINFTAEMEEELDEIAEGKVDWQKLLLEFYEKFMKQIEEGKENIVSLKLAKPLGRTCPKCGEHELLLRSGRFGNFIACSGFPKCKYTEQCDEEGNAVEKKETTADEKCDKCGADMIVKNGRNGEFLACSNYPECKNTKSINVEEKVSETPCPDCGGKISLKNSRRGPFWGCENYPDCKFISKFEPTTIKCKEEGCSGVLAPRTYRNKEVYECVKCKARTPKEEIDTKK
(375) DNA topoisomerase 1 [Arcobacter butzleri RM4018]
1
MASMGHVRDLPKSSLGFDPNDNFKPKYQISTDKKKVITDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAILKALENPRDVDQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFVPEEYWKIKADFINPELKAELAKENGKTLKISNEKQALEIEASLKQGSYKLVDIEEKESTRNPAAPFTTSTLQQEASRKLGFSVKQTMIIAQQLYEGNVGNIPNHTGGLITYMRTDSLNLSTVATTAAKAVIEEEYGKEYALNKPRVYTTKSKGAQEAHEAIRPVNLALRPSQIKEFVEPAQYRLYSLIWKRTLATQMAQAKIANTTYKIEAGKNKEFEFQVKGQRIIFAGFMKAYTEGSDNPEAALDSSEKILPNIKEGTILELEKLESEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYVSKTEDNKLIPTQTGEIVNSFLVDHFSNIVDLGFTAKIEEEFDEIAEGKIAWEEVMKNFYGGFKKTIDEKESSVSKEDYLQVNELGIDPKSGKPVSARVGRFGPFVQIGTKDDEEKPKFVAIPDNLNMDTITLEEALFLFNLPRVVGNTENGDEIKANIGRFGPYLQVKTKFYSLKTDDPYTIDLNRALEIIKDIDEAKEKSTIKTFDKEKIQILVGQYGPYIKQGRKNFKIPKGKNAEDLTLEECLEIIEKDSKGSTKRTTTKKSATEKKTTAKKTTKKSTDKK
(527) DNA topoisomerase 1 [Hippea maritima DSM 10411]
1
MNLVVVESPAKAKTISKFLGKNYSVVASYGHIRDLPKSSFGVDIEDGFKPKYVIPKDKQPIVRELKKLTKDSDLVYIATDEDREGEAIGWHITQATKLDETKLKRIAFHEITKKAILDAIKSPRSIDMDMVNSQEARRILDRIVGYKLSPLLAKKIRKGLSAGRVQSVALKLIVDREEEIQSFKPEEYWTIHLIFENSIQADLTKAYGEKFDKLFIKKEDDKARVSKLKEEIEKESFNVYSITKTKSLRKPEPPFITSTMQMAASTYLGFSAQRTMRIAQSLYEGVDIGKERIGLITYMRTDSVNIAKEALTKVRRTIKELLGDEYLPSKPVTYKTKSKLAQEAHEAIRPTDPALLPDMVKPYLTEDQFKLYDLIWRRFVASQMKPAEFRNTKITFTSYNFEAKASYKELVFDGFLRIWTFSKLNEDKIPILKKNQSVELTEVKPKQHFTEPPPRYTEASLIKELEKHGIGRPSTYATIIDTIIKRGYVVLKDKRFYPEEIGIITSRMLDKFFSDIINVKFTAQMEDGLDKIANRELTKLELLKRFYDKFKVLLENAYENMERIKPEDEPTDEVCPLCGANLVIRHGRFGKFLACSNYPKCKYTKPLQEEITEIKCDKCGAPMVVKYSRKGSKFLACSNYPKCKNTKPYPTGLKCSECGGDLIEYSSKRGRFYGCSNYPECKFTIKGELKNQKCPKCGYSLFVKKKDKWCCANKKCNYCE
(1171) DNA topoisomerase 1 [Geobacter lovleyi SZ]
1
MAHQLVIVESPAKAKTIEKFLGSEYRVLASFGHVRALPSKQGSVDTANDFEPKYHVLPESKKHIDAIKKELKGADRLLLATDPDREGEAISWHLLAALGLDKKPKIPIQRVVFHEITKDAIIHAVQHPRDIAIDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFVDQEYWTIGAKLEKQGGQTLKAGLVAVDGKKLGKFDIPDQKSADALKNAIAQGKAEVASVTRKEMKRNPAPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGVAIGEGGTVGLITYMRTDSVNLSAQALKDAHDLISVAYGKEYALAKPRFYKNKSKNAQEAHEAIRPTYLDKTPAELKKYLTPDLFKLYELIWKRTVACQMAEALLDQTSVDIAVSGQKTDSFILRATGSVIRFPGFMKLYIEGVDDEDEEKEGTLPALDEGEALKLLEVLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASTLNTLVERKYARLDKKRFFPEDVGMVVNDLLTAHFPKYVDYNFTAGLEEELDQVSRGEKQWKPLLREFWNPFISLLKQKEGEVKKDDLTTETLEEACPECGKPLAIKLGKRGKFIACTGFKEGCKYTRNLENSGTEEAAEPEVSEEKCDKCGQPMLIKSGRYGKYLACSGYPACKNIQPLNKPKGTGVTCPECKEGELTEKKSRYGKMFYSCNRYPDCKFALWDPPVTQPCPKCGFPVLVKKVYKKKGEFLKCPKEGCDYTSA
(1103) DNA topoisomerase 1 [Staphylococcus haemolyticus JCSC1435]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDVEDNYEPKYITIRGKGPVVKDLKKYAKKAKNVFLASDPDREGEAIAWHLSKILELDDSKENRVVFNEITKDAVKESFKHPRGIEMDLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKSKFTAKFLHYKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISQTAKDEAKQYIEDKYGKDYLSNRTAKGKQGDQDAHEAIRPTSTLRTPYEMKAYLTRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNNIKFRANGQTIKFKGFMTLYVEAKDDKDNEKENKLPNLSKGDEVTATQIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVYEQVKDYFPEIIDVEFTVNMETLLDKIAEGDIGWRKVIDNFYGSFKLDVERAEEEMEKVEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPKCKDGDVVERKSKKNRLFYGCSNYPECDFISWDKPVGRDCPKCNHYLMEHKKGRSSQVICSNCDYKEEVQK
(976) DNA topoisomerase 3 [Staphylococcus haemolyticus JCSC1435]
2
MKSLILAEKPSVARDIAEAMNIKGKRNGYIENEKYVVTWALGHLVTNAQPEHYDKAYKEWKLEDLPIIPKRMQTVVIGKTSKQFKTVKSLILDKKVKEVIIATDAGREGELVARLILDKVHNKKPIKRLWISSVTKKAIQEGFKKLKDGREFQHLYEAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVNARQQEINHFKAKKYYTLSTEIGGLTFQLSTNKQHMTMEDATQIANEIKHVEGNVDSVEKKVKKSHPKPLYNLTDLQQEAYQRYKMGPKETLNTIQNLYERHKVLTYPRTDSNYLTDDMVDTIKERLYALLATDYKSQVKSLLGQSYSSKMRIFKNHKVSDHHAIIPTEVRPDMQSLSNRESKIYMMVAERFLESLMAPHEYEAVRVNVTVGQHIFAFNEKVTRQLGYKALKMNNDNVVKKVAFQKGEKYHLQSLKVNEHETTPPDYFNEGSLLKAMENPQNYIQLKEKKHANTLRQTGGIGTVATRADIIEKLFNLNAIESRDGKIKVTSKGKQILDLAPQELTSPLLTAEWEEKLLLIEKGRYNSRHFIDEMKAFTQSIVNTIKNSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPTCKTKKNVQRKTNARCPNCKKKMTLFGRGKDAVYRCVCGHTETQEQMDKRFKNKSSGKVSKKEMKKYMNNEDSLENNPFKDALKNLKL
(1492) DNA topoisomerase 1 [Chromobacterium violaceum ATCC 12472]
1
MPTSLLIVESPSKAKTLKKYLGPDFEVLASYGHVRDLVPKNGAVDPEKDFAMKYQLIARNSKHVDAIVSAVREADHVYLATDPDREGEAISWHLVQILNSKKLLKDKTAQRVVFHEITKNAVLDAIQNPRDIAQDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIKAFVQQEYWSVHLDSHKSRTKFSAKLTTLGGKKLDQFDIPNEAEQASVLARLQGLPATVGSIEKKKKSRSPAAPFTTSTLQQEAVRKLGMTTDRAMRTAQQLYEGMDIGQGTVGLITYMRTDSVALANEAVEEIRGYIGLKWDADYLPKNPAVYKSKAKNAQEAHEAIRPTSILRTPEMVKPFLTTDQFKLYDMIWKRTLACQMAPAKFDTTSVDIMVGEGVFRASGQVQTFAGFLAVYEEDVDDAEDEDNAKLPLLTEGEDLPVDKLYGEQHFTQPPPRFSEASLVKALEEFGIGRPSTYASIISTLKDREYVILDKKRFLPTDTGDIVNKFLTEHFAQYVDYNFTAKLENQLDEIANGGRQWVPVMDTFWKGFKKQIDEKESISRAEVTTESLDEDCPKCGKPLSIKFGKRGRFIACTGYPECDYTRNMGETAEQAAEEAEAPTVIEGRSCPDCGGELHIKKGRYGKFIGCANYPKCKHIEPLEKPRETGVTCPECKTGQLIERKSRYGKLFYSCNTYPKCKYATWNPPIAEPCPQCNWPILTIKTTKRRGTEKVCPQKECGYAEQIAPPEGKDAAPAEEA
(1217) DNA topoisomerase 1 [Neisseria meningitidis MC58]
1
MAKNLLIVESPSKAKTLKKYLGGDFEILASYGHVRDLVPKSGAVDPDNGFAMKYQLISRNGKHVDAIVAGAKEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPREIEMDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIRAFEAQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQFDLPNEAAQADVLKELEGKEAVVTAIEKKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDSVNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPFLSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFAGFLSVYEESSDDEEGEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEYGIGRPSTYASIISTLKDREYVTLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLEDQLDEIADGKRQWIPLMDKFWKPFIKQVEEKEGIERAKFTTQELDETCPKCGEHKLQIKFGKMGRFVACAGYPECSYTRNVNETAEEAAERIAKAEAEQAELDGRECPKCGGRLVYKYSRTGSKFIGCVNYPKCKHVEPLEKPKDTGVQCPQCKKGNLVERKSRYGKLFYSCSTYPDCNYATWNPPVAEECLNCHWPVLTIKTTKRWGVEKVCPQKECGWKEQIEPPAPKE
(297) DNA topoisomerase 3 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305]
2
MKSLIIAEKPSVGRDIANTLNINEKRNGYFENNKYIVTWALGHLVTNATPEQYDASYKEWKLNDLPIIPNKMKTIVISKTRKQFSTVQSLINNNKVKDIIIATDAGREGELVARLILDKAHNKKPTKRLWISSVTNKAIKEGFNKLQDGRKFNNLYHAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVQMRQNEINHFKPQTYYTMKLNAAGLTFHCTKPQSHPDKTVLESIKKAIDGQSGHIASISKTHKKAYPQQLYNLTDLQQDAYKRFHLGPKETLNTLQTLYERHKLVTYPRTDSNYLTDDMVDTLKDRLKAIMATSLKDMAKAQMSQTFSSKQRFVNNNKVSDHHAIIPTEVRPDINQLSQRESKIYMMIAQRYLENLMPPHEYEAIAIELKVGQHTFTFKDKVTTKLGFKAIYENKESINTQIDQLQKGTKLNVTKILIEEHETTAPPYFNEGSLLKAMESPQKFFDLSDKKHDKTLKDTGGIGTVATRADIIEKLFNMNAIEARDGKIKVTSKGKQILELAPQKLTSPLLTAEWEEKLLLIEQGKYNASQFISEMKAFTNQVVNEIKESEQNYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPQCKTKKNVQRKTNARCPNCHKKMTLFGRGKDAVYRCVCGHTETQAQMDKRHKNKKSDKVNKKDLKKYMNNDEGIENNPFQDALKGLKF
(1400) DNA topoisomerase 1 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305]
1
MAENLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDAENDYEPKYITIRGKGPVVKELKKHAKKAKKVFLASDPDREGEAIAWHLANILNLEDSTENRVVFNEITKDAVKDSFKHPRGIEMELVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWKIEGEFRYKKTKFTAKFLHFKNKPFKLTEKADVEKITTQLDGDQFEVTKVTKKEKTRYPANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKKQGTVGLITYMRTDSTRISDQAQSEAKNYIQETYGNDYTSNRKSKGQGDQDAHEAIRPSSTLRTPNEMKNFLTRDQHRLYKLIWERFVASQMAPAILDTVAMDLTQNDIKFRANGQTIKFKGFMTLYVETKDDSEDGKDNKLPNIGEGEMVTATNIEPSQHFTQPPPRYTEARLVKTMEELKIGRPSTYAPTIDTIQKRNYVKNESKRFVPTELGEIVHEQVKDYFPEIIDVDFTVNMETLLDKVADGEIGWKKVISDFYSSFKQDVERAEEEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPKCKEGDVVERKSKKNRIFYGCSKYPECDFVTWDKPIGRDCPKCEHYLVEKKQGRKSQVVCSNCDYKEEEQK
(901) DNA topoisomerase 1 [Paenibacillus terrae HPL-003]
1
MADSLVIVESPSKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFNPKYITIRGKGSILKELKDARKKVKKVYLAADPDREGEAIAWHLAHALDLDDTADCRVVFNEITKQAVKDAFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIILDRENEINEFVPEEYWTITAKLAIKDSTFEAKFHQLRGEKKELSSEADVQEVLEAIGKSSYKVRDVKEKERLRNPSPPFTTSSLQQEAARKLNFRASKTMSVAQQLYEGVDLGKEGTVGLITYMRTDSTRIAVSAQEEAKEFIIQKYGEAFVPESPRQYSKKAANAQDAHEAIRPTSALRDPETVKPFMSRDQFRLYKLVWERFMASQMASAIMDTLSVDIEAGETIFRAAGSKVRFPGFMKVYVEGNDDGKTEEDKLLPPLKSGDKLKKESVEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLETIQKRGYVAIEEKKFFPTELGELVIEQMEEFFPEILNVEFTANMEGDLDHVEEGEGDWVKVLSDFYESFEKRLEVAEEEMKEIEIKDEESDVICDKCGSPMVYKLGRFGKFLACSAFPDCRNTKPIVKDIGINCPTCGEGHVVERRSKKGRIFYGCDRYPECDFVSWDKPSIKPCPSCGGLMVEKRTKQGTKLNCTVCDHSEMLEDSDEGVETS
(29) DNA topoisomerase [Paenibacillus terrae HPL-003]
7
MKTLIIAEKPDMGRTIAAVMEPRAKNNRTYLEGEKYIVTWAIGHLLGLAEPDAYDAKYKRWNIKDLPIIPEQFKIVPNPKTKDQLKIIGELAKRCNAIVNACDAGREGQYIFALIQQQLKLRQPVKRLWISDLTAESIAAGFERLRDASEFEFLTQAARARSEADWLIGMNASRAFTTRHNALLSVGRVQTPVLALIHDREKEIEAFQSQTFYDVWAEFKQDQTKYKGAWQGDRLTKPEEAEAIAAAVRGKTGEITKYDTKQTKEYPFKLYDLTLLQREANAKYSYSAKKTLDVAQALYERHKVISYPRTNSNYVTEQNIDGMHKALRMLGTGPYADLVQQANPNLVHKQNKAVCNPSRVEDHHAILPTLKRPGTLSKEEQNVYDLIIRRFLSHFFPPAEYKMHTVMTQVDKHLFKTSIKELLSLGWKVVLSKADQDKGKKSKAPKKEEEEETDEWTDKKFEIDAGRLVDCIRAEMKEKATQPPKSYTEGTLLKAMESAGKQMENEELREVMKDAGLGTPATRAATIERLKKVGYIEMKGKKILITDKGKMAIDLIRNAGVDLLASPEMTGQWERRLHQISKGEAAQEKFMDNVKKFTLSIIDKVRQQPPAPANAFGEEARGKRSAGKENARSAGASVRTAAKGTRVPSGRGSSAGSATLERTAGAAGSAAGASPSRREALGSCPRSNCSGSIIEGRKGYGCSHYKQGCGFVVWKEYAGKQITETMLKSLLTKGQTQLLSFKRKDGSTVKARIVLNEPGTGQLSVREEN
(571) DNA topoisomerase [Paenibacillus terrae HPL-003]
7
MKVLVLAEKPSVAREIARVMGSREKHKSYIEGPKYVVTWALGHLVGLAEPEDYDSKYTTWNLEDLPILPKSTKLKVLRESNHQFKAVQQLMKRQDIGELIVATDAAREGELLARWIIQMANWKKPFRRLWISSQTDKAIKEGFAKLLPGQQFDRLYESARCRAEADWMIGLNVTRALTCRYNAQLSAGRVQTPTLGMIMEREKEITQFRSQEYDTLTADFGDFQATWRAENGDSRMFDRTQAEALRRKLEGVKGTVDSVKKSEKNEPHPLAYDLTELQRDANQRYGFSAKQTSNVLQRLYEQHKLVTYPRTDSRYLTSDMVDTLKERLNSVAVGPYASLARPLLRKSLTISKRIVDDSKVTDHHAIIPTEQTLLLNQLSPEERKLYDLIARRFISLFYPPARYDAVAVAVTVEQETFQVKGTTIKDSGWRAVYDGSLYDTDEEAEEREDNGSGVILPELKKGDSVRIQRCLVRAGRTMPPKRYTEAALLAQMEKHGLGTPATRADLIEKLVSSDTIERQGNVMHPTGKGKQLIELAAPQLRTPELTARWEAELERIARGQGQPGPFLDSIRAMAKELVSTVKNSSAEYKPHNVTNSHCPDCGTKLLEKKGKQGKFLVCPSADCGYRRSGEKRLSNRRCPQCHKKMEMKEGKAGLYVRCLACGITETLDKDKQRVNKREQQKLVRQYEKQEPLGSSLGDLLKAAMDQKQGK
(1043) DNA topoisomerase 1 [Methylotenera versatilis 301]
1
MSKLLIVESPSKAKTLKKYLGSDFEVLASYGHVRDLIPKNGAVDTANDFAMKYDIIERNSKHVDAIAKAVKSADSIYLATDPDREGEAISWHIAEILKSKNLLKNKVMKRVVFHEITKSAVEHAIAEPRDISMPMVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLDALKHSHGFTAKLIQLNNQKVEQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTLQQEAVRKLGFTTSRAMRVAQQLYEGMDVGSGTVGLITYMRTDSFSIAAEAIAQIRDYVKKNFDAEYLPKAAIQYKTKSKSAQEAHEAIRPTDISRTPASVRQYLTDEQFKLYEMIWKRALACQMAPAKFDAVSVDLSVGSDANLFRASGQTLVFPGFIAVYMEGTDDEEEEGESKLPHLETGEVLTVEKIYGDQHFTEPPPRYGEASLVKILEEYGIGRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTKYVDYGFTANLEDALDSVAEGEREWLPLMAEFWQGFNQQLLSKADVERPGNELIDEACPKCGKPLQKQLSRFGTFIGCTGYNDEPKCDYKRSLNGAAQVGSDPIIIGNDDESGKEIMLMNGPYGPYLQLGLAVEGDKKKPKRVSVPKEISLADMNLETAKMVLSLPRDLGLHPVTNKKIVANIGRFGPYVNHDAKFKSIPKTDSVFTIDLDGAVALLAAAHTGPAPLATLGNHPTEDGQIEVFAGRYGPYVQHGKIRATLPKSVEPESLTLDEALELLMAKAQKEAPAKKTTTKKPTAKKAPAKKPAAAKATAKKPAATKTATKKPAAKKAAVQ
(476) DNA topoisomerase 1 [Neisseria gonorrhoeae FA 1090]
1
MAKNLLIVESPSKAKTLKKYLGGDFEILASYGHVRDLVPKSGAVDPDNGFAMKYQLISRNGKHVDAIVAAAKEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPREIEMDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIRAFEAQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQFDLPNEAAQADVLKELEGKEAVVTAIEKKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDSVNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPFLSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFAGFLSVYEESSDDEESEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEYGIGRPSTYASIISTLKDREYVTLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLEDQLDEIADGKRRWIPVMDKFWKPFIKQVEEKEGIERAKFTTQELDETCPKCGEHKLQIKFGKMGRFVACAGYPECSYTRNVNETAEEAAERIAKAEAEQVELDGRECPKCGGRLVYKYSRTGSKFIGCANYPKCKHVEPLEKPKDTGVQCPQCKKGNLVERKSRYGKLFYSCSTYPDCNYATWNPPVAEECPNCHWPVLAIKTTKRRGVEKVCPQKECGWKEQIEPPAPQE
(219) DNA topoisomerase 1 [Neisseria lactamica 020-06]
1
MAKNLLIVESPSKAKTLKKYLGGDFEILASYGHVRDLVPKSGAVDPDNGFAMKYQLISRNAKHVDAIVAGAKEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPREIEMDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIRAFEAQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQFDLPNEAAQADVLKELEGKEAVVTAIEKKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDSVNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPFLSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFAGFLSVYEESSDDEESEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEYGIGRPSTYASIISTLKDREYVTLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLEDQLDEIAGGKRQWVPVMDKFWKPFIKQVEEKEGIERAKFTTQELDETCPKCGGHKLQIKFGKMGRFVACAGYPECSYTRNVNETAEEAAERIAKAEAEQAELDGRECPKCGGRLVYKYSRTGSKFIGCANYPKCKHVEPLEKPKDTGVQCPQCKKGSLVERKSRYGKLFYSCSTYPDCNYATWNPPVAEECPNCHWPVLTIKTTKRWGMEKVCPQKECGWKEQIEPPAPKE
(1172) DNA topoisomerase [Bacillus coagulans 36D1]
2
MKSLVLAEKPSVGRELARVLGCTENKKRYIEGPRYIVTWALGHLIELKMPEDYHPKYKEWRMEDLPILPDKMEIKTIRQTYPQYKAIEQLGKRSDIKDCIIATDAGREGELVARWILEKMHWRKPVKRLWISSQTDKAIKDGFKQLKPAKQYDNLYHSAVCRSEADWLIGLNVSRALTVKYNDPLSAGRVQTPTLAMVLEREREIQSFVPKKYWTIEALAGKLEVSYDHHGEKRIFDEQKANAIHAALSGQTAVVTEVIRKQKQEQQPLPYDLTELQRDANHRFGFTAKKTLNVLQNLYEQHKLVTYPRTDSKYLTKDMENMMYDRLLAVKDAYKEEVQPILSRKGKILAKRVINDAKVTDHHAIIPTDERPALSDLSADERKIYDLIVKRFLALFYPVYEYETVQFKLQAGGKTMTGRTMAVKNAGFTAVLHHEQERENTALLSIKEGKKFKLEQIRLSQHLTEAPKRYSEADILSRMEKYGLGTPATRADIIERLVSSETISRESGRLVPTPKGKQLIDLVNDELKSPELTAKWEEQLEAIARGKGNPKQFLETIRRETVRLVREIRTSDKKYRAHNLTGTKCPECGSLMKEVNGKDGKKLVCSNRECRFTKRKSPKLSNRRCPTCHKKMEIHHGKSGVYFQCRHCNIVQKADEKKKTLSKHEEKKLLQKYTKKEESFGNSLADALKAALEKE
(1637) DNA topoisomerase 1 [Bacillus coagulans 36D1]
1
MDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIDRENEIKSFVPEEYWTIAGSFKKGKDTFQASFYGVDGKKIQLKSEADVKKITGMLKSDKFQVSSVTHKEKKRNPAPPFTTSSLQQEAARKLNFRAKKTMMVAQQLYEGIDLGKEGTVGLITYMRTDSTRISEVAKTEANQYIREKFGENYLRQEERKEKKQANAQDAHEGIRPTSIFRDPGSVKSFLSRDQYKLYKLIWERFMASQMAPAILDTMSATLANGTVLFRASGSKIQFPGFMKVYVEGSDDQQEEGERYLPHLEEGDVVQSESIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALENKRFVPTELGEIVLELIREFFPEIIDVEFTADMEKDLDEIEEGKVPWVQIIDAFYQNFEARLKKAETEMEKIEIKDEETGEMCELCGSPMVYKMGRYGKFMACSNFPDCRNTKPIVKKIGVTCPKCGKGEIIERKTKKNRIFYGCDRYPECDFVSWDKPVGRKCPKCGDMLVEKKLKKGTQIQCVHCDYKEQSVK
(1856) DNA topoisomerase [Bacillus coagulans 36D1]
7
MSFPLIIAEKPDQGRTLCSVFPHVKREGYIEIRPNEIFPEGAFCTWAIGHLTQLVPPEHYNPAWEQWKLETLPILPETFKYEVAKSKYKQFQIVKKLVKDARVTNIIHAGDAGREGELIIRNILHLCGAKKPLRRLWISSLTPQSIREGFRHLLHDEDTRPLYDEAYARACADWLVGMNASRVYSLLLRQKGMRDVFSVGRVQTPTLALIVKRELEIEHFKPEPFWEVTAMFQFDDKQYEGKWVKDGESRLNDPAMAARIAAFCRQKPAEVAELKKEKKEFQPPLLFNLSSLQAAANRAFQFPPKKTLDLVQSLYQKGIVSYPRSDSQYVTKGEAETFPGILEKLSACPEYAPYFPLPKRSILQNKRYVNEKKVSDHYAIIPTEQVVAPGSLPDGEKKIYDMIVRRLIAAHYGNAVFHYTTVKTVVDSRATFLSKGTQMEAEGWRKVIFSKEKEKDGILPDVKQGEKGVVIDTNVKEGKTQPPKRYTEGQLITLMKTAGKYIEDRELEKVMAEVEGLGTEATRAGVITILKDRKYIEVKKNQVYATDKAKVLIRAIGGKILASPEMTAKWEKRLREIGKGAAEAAAFMEQTKKLSRKIVQDAVQAAAEWDFSGLKTDDIKRPESKYTIGKKAGKCPACGGDIVDKGDFYGCSAYRKSGCTFTLSKSILGKKISLANVRKLLAGEETNMIKGFRKNGKTFDAKLKWEDGKLRFIFAKQQTGR
(1602) DNA topoisomerase [Paenibacillus mucilaginosus KNP414]
7
MKTLIIAEKPDMGRNIAAAIDPKAKNQRTYIEGEQYIITWAIGHLIGLAEPDAYDDRYKKWNLGDLPIIPEQFKLVPNAKTKDQLKVIAELAKRCSHLVNACDAGREGQHIFSLIQRHLKLKQPVKRLWISDLTPETIRRGFAELKEGADFEPLTRAAKARSEADWLIGMNGSRAFTTKHKELLSVGRVQTPVLALLYDRQKEIEAFQSNKYYEVEAWFEQGETLYRGLWQGERLTDGEKAKALAEKVKGKRGRVESYEVKDTKEYPFKLYDLTLLQREANAKFGFSAKKTLDLAQTLYEKHKAISYPRTNSNYVTEQNIPEMHRALDQLAKTDYRGLVEGADKKFVHKNNKAVCNPSKVEDHHAILPTHKTPGALPPDEAKLYDLIVRRFLSQFYPAASYKMHTVLTAAEGERFKSTIKQLLDLGWKVIYADQKKEKPTGRGKGKADGKEDDEESAEEEVQTPFTLDAAQEVRCKKSSAKEKETQPPKPYTEGTLLKAMESAGKQIEDEELRDAMKDSGLGTPATRASVIERLKNVGYVVMQGKRIAITPKGRTAVELIRGAGVELLTSPEMTGHWERRLNEIARGTASDEQFMANVKKFATMIVDKVRVQRPAEKTAFEGEAAAAGGAGRGRAAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRASHQLGRPSLTLPLHAPACRCLSAASGVRGSCASSGT
(482) DNA topoisomerase [Paenibacillus mucilaginosus KNP414]
2
MTNELQDVNNAKEAGTIHFCPERSTIRMKSLVLAEKPSVAKEIARVLGCQQKHKHYMEGPQYVVTWALGHLVTLAEPEEYDPKYKTWNLEDLPLLPSKMKLKVIRETTPQFKAISQLAQRGDLKELIIATDAGREGELVARWIMELVRWRKPYKRLWISSQTDKAIRDGFAQLKPGPAYDPLYRSAVCRAEADWLIGLNITRALTCKHNAQLAAGRVQTPTLAAMMDREAQIRSFQAKDFWMLRAQLGSFQALWRSQAHPDGRLFDKAAADTLLERLKTARSAKVSALKVSEKSEPHPLAYDLTELQRDANKRLGFTAKQTSNVLQRLYEQHKLVTYPRTDSRYLSSDMVSTLPDRLKALLGTPYGASAKGLLARPLPVTKRIVDDSKVSDHHAIIPTDERPQLQLLGADERRLYDLIVRRFLSLFFPAFRYDETAVTLDIAGESFHAKGRIVKDQGWKAVYDGSSAPSEADDDDAPEEEPSSLQSLPALQLGTELKDLRLSQQKGTTKPPGRYTEAGLLSVMEKQGLGTPATRADIIEKLLSTDTIERRMNTLQPTGKGVQLMELVVPELRSSELTASWERELERIAKGQGDPDAFMAGIRKQTEAIVRDVKNSSAEYKPHNLTHSKCPDCGSPLQDIKGKRGRMLVCSSRECNYKRAAEAQLSNKRCPQCRKKMEIHTGKAGKYAQCRPCNVIEMLNDTGGAGGRGKAGKRQQSQLAEQYSDNAKLPSALEE
(1186) DNA topoisomerase 1 [Paenibacillus mucilaginosus KNP414]
1
MADSLVIVESPAKAKTISKYLGSKYIVKASMGHIRDLPKSQIGVEVKKNFEPKYITIRGKGSVLKELKDASKRVKKVYLAADPDREGEAIAWHLAHYLELSDQDACRVVFNEITKQAVKDAFKTPRKINQDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKLIYDRENEIKAFEPEEYWTITAKLAANKSDFEAKFYSVNGEKKELKSQSEVNEVLALLGGSDFVVSEVKEKERLRNPSPPFITSSLQQEAARKLNFRAAKTMSVAQQLYEGIDLGSEGTVGLITYMRTDSTRISPVAQEEAKEYITGKYGEAYYPAEPRNYVKKNANAQDAHEAIRPSSVLREPESIKAHLSRDQFRLYKLVWERFVASQMASAVLDTMTVDLNAGPVVFRAVGSKIKFHGFMKVYVESSDEGAADAADDDKFLPPLKQGDEAKPQAIDPKQHFTQPPPRYTEARLVKALEEMGIGRPSTYAPTLETIQKRGYVAIEEKKFVPTELGELVIQQMIEFFPEILDVEFTAHMEEGLDHIEEGKEDWVRVLSEFYDSFEKRLEVAEEEMEKIEIQDEVSDEICEKCGNHFVYKMGRFGKFLACSGFPDCRNTKPIVKDTGVTCPSCHEGKIIERRSKKGRIFYGCDRYPACEFVSWDKPVEQPCPKCGALLVEKRNKSGTFIQCVSCDFKEEAKEDDRED
(754) DNA topoisomerase 3 [Staphylococcus lugdunensis HKU09-01]
2
MKGLIMKSLILAEKPSVARDIADALHITHKKNGYIENEKYIVTWALGHLVTNAQPEHYDKRYQTWNLNDLPIIPKHMKTIVIGKTSKQFKTVKSLLLNKQVNNVIIATDAGREGELVARLILDKVGNKKPIQRLWISSVTKKAIQQGFKNLQDGRKYNHLYQAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVYERQKEIKQFKPEDYYTLHIKVAGYEFDLDSQQRFKQREDLEHIVKAIAQNNIQVTTVETKRKKSYPQALFNLTDLQQEAYRRFKMGPKETLNTLQNLYERHKLVTYPRTDSNFLTSDMVETFSERLQALLATDYKVAVKNLMKKSFNTKLNIINDKKVSDHHAIIPTEIRPDLNQLTAREQKIYMLVAERFIASLMEPYQYEMTTVKLEVAQHQFKMKENIPLQLGYKALFDTTQTEVKKQPFRQGQQYPISQTNIKKHQTTPPDYFNEGTLLKAMESPQQVIHIQDKKYAQMLKQTGGIGTVATRADIIEKLFNINAIESTDGKIKVTSKGQQILDLAPEALTSPLLTAEWEEKLTRIEKGKYNQRKFIQEMQDFTTKIVHDIKNSVQTYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPSCKTKKNVQRKTNARCPNCKKKMTLFGKGKEATYRCICGYTETQRHMDERMKHKNNNKISKKEMKKYMSSDEKLENNPFKDALKNLKL
(1321) DNA topoisomerase 1 [Staphylococcus lugdunensis HKU09-01]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDVDDNFEPKYITIRGKGPVVKELKKHAKKAKKVFLASDPDREGEAIAWHLSNILELEDSKENRVVFNEITKDAVKESFKHPRDIEMDLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYQKSKFTAKFLHYKNKPFKLQNKDDVNKITAKLDGDQFEITNVNKKEKTRNPAQPFTTSTLQQEAARKLNFKARKTMMIAQQLYEGIDLKRQGTVGLITYMRTDSTRISDAAKNEAKSYITENYGSNYVSKRQAKGKQGDQDAHEAIRPTSAMRTPNEMKSYLSRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNDIKFRANGQTIKFKGFMTLYVEAKDDKENDKENKLPNLKEGDKVTATQIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLDSKRFVPTELGEIVYEQVKEYFPEIIDVEFTVNMETLLDKIAEGDMKWRKVIDDFYNSFKLDVARAEKEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPTCKKGDVVERKSKKNRIFYGCSNYPECDFISWDKPIGRDCPKCEHYLVEKKKGRSSQVVCSNCDYQEEAQK
(511) DNA topoisomerase 1 [Macrococcus caseolyticus JCSC5402]
1
MAENLVIVESPAKAKTIEKYLGKKFKVVASMGHVRDLPRSQMGVDTENDFEPRYITIRGKGPIVQDLKKHAKRAKHVYLASDPDREGEAIAWHLAHILNIDEKAASRVVFNEITKDAVKESFKHPRQIEQNLVDAQQARRVLDRLVGYNISPVLWKKVKKGLSAGRVQSVALKLIIDREEEINAFKPEEYWTIDGLFEYDRKQFKAKFLHENNKPKKLKQEDDVKAIVKQLKSDAFEVTDVTKKEKLRNPAQPFTTSSLQQEAARKLNFKARKTMMLAQQLYEGIDLKKQGAVGLITYMRTDSTRISDTAKNEAASYIEEHYGKAYLSKRSSKSGGAQDAHEAVRPTSVMRTPSEMKAYLSRDQLRLYKLIWERFMASQMAAAVIDTVSVDLVQNNIKFRANGQTIKFKGFMSVYIEGQDEETEDGENKLPVLEVGDTVKAVNIDENQHFTQPPPRYTEARLVKTMEEKGIGRPSTYAPTIDTIQKRNYVKVDQKKFYPTELGIIVNESVKEYFPEIIDVDFTVNMETLLDKIASGDMEWKKVISTFYGDFKTHVERAEAEMEKIEIKDEPAGEDCEKCGSPMVYKMGRYGKFMACSNFPECRNTKAIVKTIGVACPKCKDGEVVERKSKKNRIFYGCSNFPECDYISWDKPIARNCPKCDTQLVERKKGKQTQVVCTNCDYDEKPQ
(1347) DNA topoisomerase 3 [Macrococcus caseolyticus JCSC5402]
2
MKSVVLAEKPSVARDIARVLKCNQKKNGYMENDKYIVTWALGHLVTNADPEQYDAKYKQWDLNMLPIIPERMKTVVIGKTRKQFNTVKAQIERQDVNEIIIATDAGREGELVARLIIEKCKGNKPMKRLWISSVTDKAILDGFKHLKPAQAYQGLYEAAMARSEADWIVGINATRALTTKYDAQLSTGRVQTPTLQMVKIRQDAVQKFQPKTYYSIELVSGSDKFKWQSGSQIFDESKVDGLLKDIQGKQAVVQDVVSKEKKRYPGKLYDLTSLQQDAYKRFKYSAKETLNAMQSLYETHKYVTYPRTDSNYLTTDMESSLKERVASLGATPYKDQVVKLLKTHIKGGSHFINNAKVSDHHAIVPTEIRANLEALGAREKNIYLLIAERFLSNLMEPHIYNEETITVQIGKEIFTLKTETTVKAGFKALYEQSSIERHKVYHKGEVLSSVSLKKTTGETQPPAYLNEGTLLKAMENPASIFNIDKESTTTLKSAGGIGTVATRADIIEKLYNLNAIENNNGNIKVTNKGRQLLELAPDALKSPELTADWEHKLTRIEKNKYGRKQFMREMIDFTKEIIDEIKSSDEKFKHDNLTSTECPTCGKFMLEKKTRNGKMLVCQDPTCGTKKNVQRKTNVRCPECKKKLTLHGKGPKAMYSCVCGFRETQEQMDKRFNSKKTGKVSKKEINKYMKKEEPINNPFADALKNLNL
(1713) DNA topoisomerase [Bacillus cellulosilyticus DSM 2522]
7
MKLIIAEKPDQGAKLAAPFSSKKQAGFIEISPNDTFPKGALVTWAVGHLCELVPPDYYHPHWKKWSLKNLPIIPEQFQHRVITSKWKQFNIIKRLIHDQRITEIIIAGDAGREGEAIIRIVLTLCKNSKPMKRLWISSLTKNAVLTGFNHLLDEAETRSLYYEALSRSCADWIVGINASRAYTLLLQQKGIKDIFSIGRVQTPTLALIVQREKEIETFKQEEFWEVVATFHMNNNQYKGKWHKENDSRLKEKELAEKIRRFCVHKEATIQSIEKKRKDFKPPFLLNLSNLQALANKRFKYSPQKTLDIAQKLYTKGIISYPRSDSNFITKEEAKMLPDILFKLSKLEHFEKYFPLQVESILNNKRYVNDKKVSDHYAIIPTEQVTNPTKLQSEESNIYILIVEQLIAAHYKSAIIDYTTIQTLVDNRATFLTKGKEIVQAGWREVLYKNDDKASNDEDQQLPALREGESGHVFDVDIKSGKTQPPKRFTEGELITVMKTAGKALDDKELVHILKNTEGLGTEATRAGIIQVLKDRKYIQVIKNQVFVTEKGKLLVEAVGDSILASPEMTAKWEKRLSEIGEGKAAPKIFIEQAKNLACNVLETANKQVENWDFKNIDISSIESFSSKNKKGRRQTVVGKCKKCDGQIIDKGSFYGCSNYRNTNCSFTLSKILLGKTITQTQVKKLLTKGKTDIIHGFKKNSKTFNASLILNTTTYKLEFKWDN
(1822) DNA topoisomerase 3 [Bacillus cellulosilyticus DSM 2522]
2
MKKSVVIAEKPSVARDIARVLKCNKKGNGFIEGDKYIITWALGHLVTLADPEAYDQKYKSWKIEDLPMIPNHLKLVVIKKTSKQFHAVKSQLHRSDVGDIIIATDAGREGELVARWIIEKAKISKPTKRLWISSVTDKAIKEGFQQLKNAKAYENLYESAVARSEADWYIGLNATRALTCKYNAQLSSGRVQTPTLAIISQREEEIRSFRPKAFYGITAKTEENLSLSWQDKRSKDFRSFSKDNITNILSNIKGNNATVVEVSKKNKKNFAPQLYDLTELQRDANKAFHYSAKETLSIMQRLYEQHKVLTYPRTDSRYISDDIVDTLKDRVIACGKSYSEYSKLANKIVQKPLQANKSFVDNTKVSDHHAIIPTEEVANIAMFSDKERKIYDLVVKRFLAVLSPPFEYEQTTIVAEIASETFIARGKKVNSLGWKEVYGNVIEDEESDDVKEQVIPQIVKGDTLTITKVSQTEGETKPPARFNEATLLSAMENPAKYIVGETKELAKTLEKTGGLGTVATRADIIEKLFNSFLIEKKEKDIHLTSKGKQLLDLVPSDLKSPALTGEWEQKLEAIAKGNLKKNDFINDMKEYAKTVVHEIKNSDKKFKHNNMTGTKCPECGKNMLEVNSKKGKMHICQDRECGHRKNISKVTNARCPKCKKKLELRGQGEGQVFACKCGHKEKLATFNERKKKEKNTKLSKREVNNFMKKQNKQQDDEPFNPALADALAKLKLK
(1364) DNA topoisomerase 1 [Bacillus cellulosilyticus DSM 2522]
1
MSDYLVIVESPAKAKTIGKYLGKKYAVKASMGHVIDLPKSQMGVDVEEGFTPKYITIRGKGPILKDLKAAAKKAKRVYLAADPDREGEAIAWHLAHSLNIDEKSECRVVFNEITKQAIKDSFKRPRTINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIDREKEINAFEPEEYWSIDAKFEKDGEAFEAKFISKDGEKLSLKSENDVKEVLKALSGESFQIEKVKKRERKRNPVVPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDIGKLGTVGLITYMRTDSTRLSETAKAEAKTYIESHYGKEYVNQQEAKTKQKSNSQDAHEAIRPTSVDLDPKSVKSYLSRDQLRLYKLIWERMVASQMAPAILDTMSVDLVNNGVAFRATGSKLKFAGFMKVYIEGNDDGKKEEDRLLPEMSEGEQAKAEAIDPNQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQRRGYVALEDKRFIPTELGEIVLELIEEFFPEILNVTFTAKMENDLDSIEDGEEEWVKVIDEFYSDFERRLKTAEEEMKEVEIKDEPAGEDCEKCGHEMVYKMGRFGKFMACSNFPDCRNTKAIVKDIGVKCPECKEGNVVERKSKKRRIFYGCDRYPECEFISWDKPIARKCPKCEHMLVEKKTKKGIHVQCSKCDYREDQN
(63) DNA topoisomerase 3 [Bacillus licheniformis DSM 13 = ATCC 14580]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDRYIVTWALGHLVTLADPEGYGKEYQSWRLEDLPIIPEPLKLVVIKKTGKQFQAVKSQLIRKDVKDIVIATDAGREGELVARWIIEKAKVTKPLKRLWISSVTDKAIKDGFKNLKNGKDFENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREEDIKNFKPVPYFGLRAAVDGMTLTWQDKKTSQTRTFNASVTSQLAGALQGKPAVIVDLKKTAKKSFAPGLYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSNDIVPTLKDRLEGMQVKPYAQHVARILKRGVKANKSFVNDAKVSDHHAIIPTEEPLALGALSEKERKLYDLIAKRFLAVLMPPFEYEETKVFAEIGGETFTAKGKTVQSQGWKAVYDFADEDDDEEEKDQTLPKLAKGDTLSVRSLTETKGETKPPARFNEGTLLSAMENPAAFMQGEEKNLVKTLGETGGLGTVATRADIIEKLFNTFLIEKKGKDIYITSKGKQLLELVPSDLKSPALTAEWEQKLSGIAKGKLKSSAFIKEMKEYAKQTIREIKSSNQKFKHDNITGTHCPDCGKLMLKVNGKRGTMLVCQDRECGHRKTVAKQTNARCPVCHKRMELRGHGEGQTFACVCGHREKLSVFEKRRAKDKNSKASKRDVHSYMKKQNKDEPINNALAEQLKKLKLDQ
(1156) DNA topoisomerase 1 [Bacillus licheniformis DSM 13 = ATCC 14580]
1
MSEYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFIPEEYWTIEGSFLKGKETFEASFFGINGEKHQLKSEDDVKQILSRIKGNKFEVKKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAQEEAASFIGEQYGKEFLGSKRKPAKKNENAQDAHEAIRPTSVLRKPSDLKAVLGRDQLRLYKLIWERFVASQMAPATLDTMSVDLENNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKNKMLPDLAEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFIPTELGEIVLDLIMEFFPEIINVEFTAKMEKELDDVEDGNIQWVQIIDSFYKDFEKRVEKAEAEMQEVEIEPEYAGVDCEACGHPMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPSCKTGNIVERKSKKRRIFYGCDRYPECEFVSWDKPLERKCPKCEDMLVEKKLKKGVQVQCVNCDYKEEQQK
(1157) DNA topoisomerase 1 [Bacillus licheniformis DSM 13 = ATCC 14580]
1
MSEYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFIPEEYWTIEGSFLKGKETFEASFFGINGEKHQLKSEDDVKQILSRIKGNKFEVKKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAQEEAASFIGEQYGKEFLGSKRKPAKKNENAQDAHEAIRPTSVLRKPSDLKAVLGRDQLRLYKLIWERFVASQMAPATLDTMSVDLENNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKNKMLPDLAEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFIPTELGEIVLDLIMEFFPEIINVEFTAKMEKELDDVEDGNIQWVQIIDSFYKDFEKRVEKAEAEMQEVEIEPEYAGVDCEACGHPMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPSCKTGNIVERKSKKRRIFYGCDRYPECEFVSWDKPLERKCPKCEDMLVEKKLKKGVQVQCVNCDYKEEQQK
(62) DNA topoisomerase 3 [Bacillus licheniformis DSM 13 = ATCC 14580]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDRYIVTWALGHLVTLADPEGYGKEYQSWRLEDLPIIPEPLKLVVIKKTGKQFQAVKSQLIRKDVKDIVIATDAGREGELVARWIIEKAKVTKPLKRLWISSVTDKAIKDGFKNLKNGKDFENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREEDIKNFKPVPYFGLRAAVDGMTLTWQDKKTSQTRTFNASVTSQLAGALQGKPAVIVDLKKTAKKSFAPGLYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSNDIVPTLKDRLEGMQVKPYAQHVARILKRGVKANKSFVNDAKVSDHHAIIPTEEPLALGALSEKERKLYDLIAKRFLAVLMPPFEYEETKVFAEIGGETFTAKGKTVQSQGWKAVYDFADEDDDEEEKDQTLPKLAKGDTLSVRSLTETKGETKPPARFNEGTLLSAMENPAAFMQGEEKNLVKTLGETGGLGTVATRADIIEKLFNTFLIEKKGKDIYITSKGKQLLELVPSDLKSPALTAEWEQKLSGIAKGKLKSSAFIKEMKEYAKQTIREIKSSNQKFKHDNITGTHCPDCGKLMLKVNGKRGTMLVCQDRECGHRKTVAKQTNARCPVCHKRMELRGHGEGQTFACVCGHREKLSVFEKRRAKDKNSKASKRDVHSYMKKQNKDEPINNALAEQLKKLKLDQ
(1429) DNA topoisomerase 3 [Bacillus subtilis subsp. spizizenii TU-B-10]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGHLVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVIATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKDLEGKQAVIAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMADEDDEQEDDRDQTLPALQKGDALTVRMLTETNGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKDKDIFITSKGKQLLQLVPEDLKSPALTAEWEQKLSAIAAGKLKSSVFIKDMKAYANQTVKEIKNSSQTFRHDNVTGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKKMELRGQGEGQTFACVCGHREKLSVFEKRKNKDKGRASKRDVSSYMKKQNNKEEPINNALAEQLKKLGLDK
(791) DNA topoisomerase 1 [Bacillus subtilis subsp. spizizenii TU-B-10]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPLKSEADVKDILSQLKGNKYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQAYGKEFLGGKRKPAKKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMSVDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVGLDNKRFVPTELGQIVLELIMEFFPEIINVEFTAKMEKDLDNVEEGNIEWVQIIDNFYTDFEKRVKKAESEMKEVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGEGNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVECDYKEEPQK
(1664) DNA topoisomerase 1 [Brevibacillus brevis NBRC 100599]
1
MADTLVIVESPTKAKTIGKYLGSKYIVKASIGHVRDLPKSQMGVDVTHNFEPKYITIRGKGDVLKGLKDAAKKVKKVYLAADPDREGEAIAWHLAQYLGLDMNQPLRVVFNEITKDAIKEAFKHPRHINMDLVNAQQARRILDRLVGYNISPILWKKVRKGLSAGRVQSVAVKLIMDREREIQEFIPEEYWTIASTLISDGKEINAKFYGYGDEKVELHSEDDVAAVLKRMKNKPYVVQKVTKRERKRNPAPPFITSSLQQEAARKLNFRTSKTMRIAQELYEGIDVGNKEGAVGLITYMRTDSTRLSVTAQNEAKEYILEKYGPDYVLSEPRNQAKNENAQDAHEAIRPTGVMRTPDEIKEYLSRDQLRLYRLIWERFLASQMSSAVLDTMSVDIDAGGVTFRATGSKVKFPGFMKVYIEGNDDGTEEESFLPPIEEGQILDQKEIEPSQHFTQPPPRFSEARMLKSMEEMGIGRPSTYAPTLETIQKRGYVALEEKRFVPTELGEIVITLVEEFFPEILNVEFTAHMESGLDNIEAGNTNWVQVLDDFYQDFAKRVVVAEEEMKEVELKVEESDETCELCGSVMVYKLGRFGKFLACSGFPDCRNTKPIVKEIGVKCPQCETGEIIERKSKKSRIFYGCNQYPECDFVSWDKPIARPCPKCSSMLVEKKRKKQGVSIICTKCDYQEEADS
(1622) DNA topoisomerase 3 [Brevibacillus brevis NBRC 100599]
2
MSKTVVLAEKPSVGRDIAKVLQCHKKGNGFFEGDKYIVTWALGHLVTLADPEAYGQQFGSWRIEDLPIMPSPLRLVVIKESNRQFQVVKQQLRRNDVGQIVIATDAGREGELVARWILELVHVNKPIKRLWISSVTDKAIREGFRNLKDGKNYENLFASAAARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAIVATREEEIRRFTPKPFYGLSAVAQGPIQLQWQDQQTKDFKTFSKEKADQLIAALKQEKNAEVIEITRAHKKTYAPQLYDLTELQRDANRMFGYSPKQTLSIMQGLYEHHKAVTYPRTDSRYLSADIVETLPDRIKAVQMKPYAPLAARILRAPIKANKSFVDDSKVSDHHAIIPTEQAVFLGDLSDKERKIFDLIVKRFLAVLLPAFEYEQTTIQAKIGNETFLAKGKTVLSQGWREAYDHDVEEDDAKDGVKEQILPSLAKGDRLQIQSISQTKGETKPPEPFTEASLLSAMENPAKYMANESKDLIKTIGETGGLGTVATRADVIEKLFNSFLLEKRGKHIFVTAKAKQLLELVPDEMQSPTLTAQWEQKLGAIAKGSLNKRAFIEEMKTYAKEVVQQIKNSDQTFRHDNLTRSRCPECNKFLLEVNGKRGKMQVCQDRECGYRKSIAKQTNARCPKCHKRLELRGEGEGQTFVCGCGHKEKLKTFQERRDKEKGSKVSKKEVSKYLKGQDKEPDEGINSALKDALSKLKFD
(166) DNA topoisomerase [Brevibacillus brevis NBRC 100599]
7
MKILIIAEKPDMGRNIAAAIDPKAKNHRTYLEGEKYMITWAIGHLIELAEPEAYDQKYKKWNINDLPIIPEPFKLVPNRKTIDQLKIIGQLAKRSNLLVNACDAGREGQHIFSLIQRHLKLTQPVKRLWISDLTPETIRKGFAEMKDAAAYENLTRAAKARSEADWLIGMNGSRAFTTKHNVLLSVGRVQTPVLALIYDRQKQIEAFSSVTFFQVEGHFSQGERMYKGLWQGDRLTDPAKAEMLARKVKGKQGRIASYEVKDTKEYPFKLYDLTLLQREANGKYGFSAKKTLDIAQALYEKHKVISYPRTNSNYVTEQNIPEMHNTLSSLQGTGYDALVKGANRSLVHKGNKFICNPAKVDDHHAILPTNRKASGLTPDEQKLYDLIVRRFLSQFYPPAEYKMHTVITDVENEFFRTSVKEQKSLGWKIIYADQQKEKPKNGKGTAKEEEDKEEIEVNEPFIIQSDASVVCSDAMVKEKETQPPKHFTEGTLLKAMESAGKQIEDEELRDAMKESGLGTPATRAATIERLKKVGYVEMQGKKVQLTLKGRTVIELIRGAGIELLTSPEMTGHWERRLNEISRGTAADGQFMENVKKFATMIVEKVRVQSRAEKTLFESESTTQKGSSKTRGRAGGRSTGKSGGSTATTRASTRSAAKTATTTSSIITKCPRPGCGGSIFMGRKGYGCSNYNVGCKFVIWKENYGRMLTDTQIKALIEKGKTGKMKLERQDGTPFQAKLILKSVESGELTFEQ
(1875) DNA topoisomerase [Paenibacillus polymyxa M1]
7
MKVLVLAEKPSVAREIARVMGSREKHKSYIEGPKYVVTWALGHLVGLAEPEDYDSKYATWNLEDLPILPKNSKLKVLRESNHQFKAVQQLMKRQDIGELIVATDAAREGELLARWIIQMANWKKPFRRLWISSQTDKAIKAGFAKLLPGQQFDRLYESARCRAEADWMIGLNVTRALTVRYNAQLSAGRVQTPTLGMIMEREKEITQFRSQEYDTLTADFGHFQATWRAENGDSRMFDRTQAETLRHRLEGAKGTVVSVKKSEKNEPHPLAYDLTELQRDANQRYGFSAKQTSNVLQRLYEQHKLVTYPRTDSRYLTSDMVDSLKERLSSVAVGPYASLARPLLRNKLPITKRVVDDSKVTDHHAIIPTEQTLLLNQLSPEERKLYDLIARRFISLFYPPARYDAVAVSVMVGQETFQVKGTTIKDSGWRAVYDESHYELDDEEIDDRENNGRGVILPELKKGDSVQLQRCIVRAGRTMPPKRYTEAALLAQMEKHGLGTPATRADLIEKLVSSDTIERQGNVMHPTGKGKQLIELAAPQLRTPELTARWEAELERIARGQGQPEPFLNSIRAMAKELVSTVKNSSAEYKPHNVTNSHCPDCGTKLLEKKGKKGKFLVCPSADCGYRRSGEKRLSNRRCPQCHKKMEMKEGKAGLYVRCLPCGITETLDKDKQRVNKREQQKLVKQFEKKDSFGSSLGDLLKAAMEQKQGE
(1285) DNA topoisomerase [Paenibacillus polymyxa M1]
7
MECMKTLIIAEKPDMGRTIAAVMEPRAKNNRTYLEGEKYIVTWAIGHLLGLAEPDAYDAKYKRWNIQDLPIIPEQFKIVPNPKTKDQLKMIGELAKRCNAIVNACDAGREGQYIFALIQQQLKLRQPVKRLWISDLTAESIATGFERLRDASEFEFLTQAARARSEADWLIGMNASRAFTTRHNTLLSVGRVQTPVLALIHDREKEIEAFQSQTFYDVWAEFKQDQIKYKGAWQGDRLTKPEEAEGIAAAVRGKEGKITKYDTKQTKEYPFKLYDLTLLQREANAKYGYSAKKTLDVAQALYERHKVISYPRTNSNYVTEQNIDGMHKALRMLGTGPYADLVQQANPNLVHKQNKSVCNPSRVEDHHAILPTLKRPGTLSKEEQNVYDLVIRRFLSHFFPPAEYKMHTVMTQVDKHLFKTNIKELLSLGWKVVLSKADQDKGKKSKTSKKEDEEETDEWTDKKFEIDAGRPVDCVRAEMKEKATQPPKSYTEGTLLKAMESAGKQMENEELREVMKDAGLGTPATRAATIERLKKVGYIEMKGKKILITDKGKMAIDLIRHAGVDLLASPEMTGQWERRLHQISKGEAAQEKFMDNVKRFTLSIIDKVRQQPPAPAHAFGEEARSNRSGGKGNARSVGASGRATAKGMDRTPSGGGSSAGSAALKQAAPPTRRSSATKAVRSSSDGQSDASVSQRQALGSCPCSNCGGSIIEGRKGYGCSHFKQGCGFVIWKEYAGKQITETMLKSLLAKGQTQLLSFKRKDGSTVKARIVLDVPGTGQLSVREES
(247) DNA topoisomerase 1 [Paenibacillus polymyxa M1]
1
MADSLVIVESPSKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFNPKYITIRGKGSILKELKDARKKVKKVYLAADPDREGEAIAWHLAHALELDDTADCRVVFNEITKQAVKDAFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIILDRENEINEFVPEEYWTITAKLAIKDSTFEAKFHKLHGEKKELSSEADVQEVLEAIGKSSYKVRDVKEKERLRNPSPPFTTSSLQQEAARKLNFRASKTMSVAQQLYEGVDLGKEGTVGLITYMRTDSTRIATSAQEEAKEVIVQKYGEDFVPESPRQYSKKSANAQDAHEAIRPTSALRDPETVKPFMSRDQFRLYKLIWERFMASQMASAIMDTLSVDIEAGEAIFRAAGSKVRFPGFMKVYVEGNDDGKTEEDKLLPPLQPGDKLKKESVEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLETIQKRGYVAIEEKKFFPTELGELVIEQMEEFFPEILNVEFTANMEGDLDHVEEGEGDWVKVLSDFYESFEKRLEVAEEEMKEIEIKDEVSDVICDKCGSPMVYKLGRFGKFLACSAFPDCRNTKPIVKDIGMNCPTCGEGHVVERRSKKGRVFYGCDRYPECDFVSWDKPSIKPCPSCSGLMVEKRTKQGTKLNCTVCDHSEMLEESDESVETS
(598) DNA topoisomerase [Paenibacillus sp. JDR-2]
2
MKSLVLAEKPSVAKEIARVLGCSSKNKSYMEGPDYVVTWALGHLVTLAEPEDYDPKYKTWNLEDLPLLPGKMNLKVMRETSHQYKAVAQLCKRPDIGELIIATDAGREGELVARWIMELVHWRKPFKRLWISSQTDKAIKDGFKALKPGQQYNNLYASAVCRAEADWLIGLNVTRALTVKYNAQLAAGRVQTPTLGALIDREKEINQFQSQPYWTVSAELGAFQALWRQNDNHDGRVWDRSEAEAVIARLQGKSAKVDKLRTTQKSEPHPQAFDLTELQREANKRLGFSAKMTSNVLQKLYEQHKLVTYPRTDSRYLSSDIVPTLKGRLESVAVGPYAPLARKLLRGQLTVTKRFVDDSKVSDHHAIIPTDEYVNLSALSNDERKLYDLIVRRFIALFYPPYTYDETSVVLTVGQDKLYAKGKVQKDIGWKELYGGSDARFTADEDDEEENGRGEDKSTPEQLLPELVQGQAVQVKQSRLKELRTLPPARYTEASLLSKMEKHGLGTPATRADIIEKLLSTDTIERTQNRLVPTSKGKQLIELVVDELRSPELTAKWERELELIAHGQGDAKRFMAGIREQANKWVTAVKNETKEYKPHNLTHSRCPECGKLLMEVKGKRGKSLVCSDRECSYRRQAEPALSNKRCPQCHKKMEIHNGKAGKYAQCRPCNVIEMLGDKQGGRVNKHQQKKMIEQYSDNVSLSNSLADALKAAMNKQDND
(648) DNA topoisomerase [Paenibacillus sp. JDR-2]
7
MKTLIIAEKPDMGRTIAAVVEPKAANKRTYLEGDRFIITWAIGHLVTLAEPDQYDARYKRWNDQDLPIIPDKFKLWPNARTKDQLKTIGELAKRCGRLVNACDAGREGQLIFHLIRQYLKLPQPTDRLWISDLTPETIRKGFDSLRSDEDYAPLTRAARARSEADWLIGMNASRAFTIRHKALLSVGRVQTPVLALLYDRHKEITAFKSDMYYVVKALFDQNGFQYSGIWQGDRITDKAKAEALAAKTQGKPGFIKDYQTAESKEYPFRLHDLTLLQREANGRYGYSAKKTLDIAQALYEKHKAITYPRTNSNYVTEENLPVMQKVLTMLQGSDSYRELANGADRGRVHKGNKAVCNPSKVEDHHAIMPTPKRPSGLSPEEQNIYDMIVRRFLSQYYPPAVYKNHTVLTEVESEIFRTKAKELLELGWKVVLQDQGQAAKKTSKKKSSEKDEAESDDEELLTDKPFAIEPQQGVKCVKSESLEKTTQPPKSFTEGTLLKAMESAGKSMEDDELREAMKDTGLGTPATRAATIERLKQVGYVDLTGKKLEISSKGCAAIELIRGAGVDLLASPEMTGRWEQRLHQISRGEASDDQFIMKVKQFAAMIVDKVRQQRPAAPGTFEERESGGKRGAAGTKRGSRTSKPSGGGRPSSTRSSTSASATATAAPKAASRTAASPTVREPIAACPRAGCSGHIIEGKRGFGCSSFRDGCTFVIWKEQQGKTISIPMVRSLLEKGATSQLTFKRQDGSSTKAKLVLTDRDKGTVSVQGV
(1346) DNA topoisomerase 1 [Paenibacillus sp. JDR-2]
1
MADSLVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQTGVEVENGFQPKYITIRGKGSVLKELKDASKKVKHVFLAADPDREGEAIAWHLAHYLELDETDTCRVVFNEITKQAVKDAFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVCVKLIIDRENEIDAFIPEEYWSITAKLTQQGVPFEAKYHSIKGEKRELHNEEEMQAILAALSGNQFKVAEVKEKERLRNPAPPFITSSLQQEAARKLGFRASKTMSVAQQLYEGVELGKEGTVGLITYMRTDSTRISPVAQEEAKEYIEGKYGPSFYPEQPRVYTKKNSNAQDAHEAIRPTSTLRDPESMKPFLSRDQFRLYKLVWERFVSSQMASAVLDTMTVDLASGDVTFRASGSKIKFAGFMKVYVEGNDDGTEEEHKFLPPFAIGDVVTSDSIEPKQHFTQPPPRYSEARLVKTLEELGIGRPSTYAPTLETIQKRGYVAIEEKKFIPTELGDLVNQLMEEFFPEILDSEFTAKMETDLDHVEDGMEDWVRVLSQFYESFEKRLEVAEEEMKEVEIQDEVSDEICEKCGRHMVYKMGRFGKFLACSGFPDCRNTKPIVKDIGVTCPKCGEGKIIERRSKKGRIFYGCDTYPACDYVSWDKPTNKPCPNCDSMLVEKRNRSGAKLQCPNCDYSEEISEDEQEQA
(109) DNA topoisomerase 1 [Listeria monocytogenes M7]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLELDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVNGKKKKLSTADDVKEVMSAIKGKSFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEASNYIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSAMRSPQEVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVKTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFIPTELGEIVNEMIEDYFPEILDVKFTANMESELDEVEHGEVEWVKVIDEFYKRFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVYKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERACPKCEKRALVEKKLKKGVQVQCTNCDYKESTQQ
(758) DNA topoisomerase 3 [Listeria monocytogenes M7]
2
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDSKYKNWNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDYAKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYYSAVARSEADWVVGINATRALTTKYNAQLSCGRVQTPTLAMIQYREEEIRNFKPREYYGITALTEQESFTWNNGQTFDKALAEKLVKSLQGENAVITDVSMKEKKNFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERHKVLTYPRTDSRFISTDIVPTLKERLAACGVGENAKAARQISGKPIKANKSFVDNSKVSDHHAIIPTEQPVSLGDLSDKERKIYDLVVKRFLAVLSDPYIYEETSVKAKIGQEEFTLKGKVVKSLGWKSIYGESREPDQLTKMKKGDTIPVKRINLETGKTKPPARFNEATLLSAMENPSKYMETTSKALAKTLGETGGLGTVATRADIIEKLFNSFSLEKQGKDIQITSKGRQLLELVPEDLKSPELTARWEQKLSKIAKGELDYRKFTAEMRDYAKKAVTEIKQNDKKFRHDNITSQKCPDCGKPMLKVKGKRGTMLVCQDRECGHRESVSRTTNARCPNCHKRMEMRGEGDKQIFVCVCGHREKLSAFQQRRDKQKNKNVSKTDVAKFMKKQNKQEDEPFNNPMAEALAKLKLDK
(1003) DNA topoisomerase 1 [Listeria welshimeri serovar 6b str. SLCC5334]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLELDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVEGKKKKLSTADDVKEVMSAIKGKTFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEAGNFIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSAMRSPQEVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVKTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFVPTELGEIVNEMIEEYFPEILDVKFTANMESELDEVEHGEVEWVKVIDEFYKQFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVYKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERACPKCNERALVEKKLKKGVQVQCTNCDYKESTQQ
(277) DNA topoisomerase 3 [Listeria welshimeri serovar 6b str. SLCC5334]
2
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDSKYKNWNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDYAKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYHSAVARSEADWVVGINATRALTTKYNAQLSCGRVQTPTLAMIQHREEEIRNFQPREYYRITAQTEQECFTWNIGQTFDKALAEKLVKSLQGENAVITDVSMKEKKTFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERHKVLTYPRTDSRFISTDIVPTLKERLTACGVGENAKAARQISGKPIKANKSFVDNSKVSDHHAIIPTEQPVSLGDLSDKERKIYDLVVKRFLAVLSDPYIYEETSVKAKIGQEDFTLKGKVIKSLGWKSIYGEAREPDQLTKMKKGDTIPVKRVNLETGKTKPPARFNEATLLSAMENPSKYMETTNKALAKTLGETGGLGTVATRADIIEKLFNSFSLEKQGKDIQITSKGRQLLELVPEDLKSPELTARWEQKLSKIAKGELDYRKFTAEMRDYAKKAVTEIKQNDKKFRHDNITSQKCPDCGKPMLKVKGKRGTMLVCQDRECGHRESVSRTTNARCPNCHKRMEMRGEGDKQIFVCVCGHREKLTAFQQRRDKEKNKNVSKTDVAKFMKKQNKQDEEPFNNPMAEALAKLKLDK
(581) DNA topoisomerase 1 [Listeria ivanovii subsp. ivanovii PAM 55]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLDLDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVNGKKKKLSTADDVKEVMSAIKGKSFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEAGNYIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSSMRSPQAVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVRTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFIPTELGEIVNEMIEEYFPEILDVKFTANMESELDEVEHGQVEWVKVIDEFYKQFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVYKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERACPKCNERALVEKKLKKGVQVQCTNCDYKESTQQ
(463) DNA topoisomerase 3 [Listeria ivanovii subsp. ivanovii PAM 55]
2
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDPKYKNWNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDYAKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYHSAVARSEADWVVGINATRALTTKYNAQLSCGRVQTPTLAMIQHREEEIRNFKPREYYGITALTEQECFTWNNGQTFDKALAEKLVKSLQGETAVITDVSMKEKKTFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERHKILTYPRTDSRFISTDIVPTLKERLQACGVGENAKAARQISSKPIKANKSFVDNSKVSDHHAIIPTEQSVSLGDLSDKERKIYDLVVKRFLAVLSDPYTYEETSVKAKIGQEDFTVKGKVVKSLGWKSIYGETREPDQLTKMKKGDKIPVKRVNLETGKTKPPARFNEATLLSAMENPAKYMETSSKALAKTLGDTGGLGTVATRADIIEKLFNSFSLEKQGKEIQITSKGRQLLELVPEDLKSPELTARWEQKLSKIAKGELDYRKFTAEMRDYAKKAVLEIKQNDKKFRHDNITSQKCPDCGKPMLKVKGKRGTMLVCQDRECGHRESLSRTTNARCPNCHKRMEMRGEGDKQLFVCVCGYREKLSAFQERRDKQKNKNVSKTDVAKFMKKQNKQEDEPFNNPMAEALAKLKLDK
(39) DNA topoisomerase 1 [Listeria seeligeri serovar 1/2b str. SLCC3954]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLDLDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVNGKKKKLSTADDVKEVMSTIKGKTFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEAGNYIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSAMRSPQAVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVKTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFIPTELGEIVNEMIEEYFPEILDVKFTANMESELDEVEHGQVEWVKVIDEFYKQFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVFKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERVCPKCNERALVEKKLKKGVQVQCTNCDYKESTQQ
(595) DNA topoisomerase 3 [Listeria seeligeri serovar 1/2b str. SLCC3954]
2
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDPKYKNWNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDYAKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYHSAVARSEADWVVGINATRALTTKYNAQLSCGRVQTPTLAMIQYREEEIRNFKPREYYGIKALTDQECFTWNIGQTFDKALAEKIVNSLKGETAVITDVSMKEKKTFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERHKILTYPRTDSRFISTDIVPTLKERLQACGVGENAKAARQISSKPIKANKSFVDNGKVSDHHAIIPTEQSVSLGDLSDKERKVYDLVVKRFLAVLSEPYIYEETSVKAKIGQEDFTLKGKVVKSLGWKSIFGEAREPDQLTKMKKGDKLPVKQINLETGKTKPPARFNEATLLSAMENPSKYMETSNKALAKTLGDTGGLGTVATRADIIEKLFNSYSLEKQGKDIQITSKGRQLLELVPEDLKSPELTARWEQKLSKIAKGELDYRKFTAEMRDYAKKAVSEIKQNDKKFRHDNITSQKCPDCGKPMLKVKGKRGTMLVCQDRECGHRESLSRTTNARCPNCHKRMEMRGEGDKQLFVCVCGYREKLSAFQERRDKQKNKNVSKTDVAKFMKKQNKQEEEPFNNPMAEALAKLKLDK
(533) DNA topoisomerase 1 [Bacillus anthracis str. CDC 684]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(895) DNA topoisomerase [Bacillus anthracis str. CDC 684]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLDTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTEIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDESDTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYDGKWEKDNESRLQDPDMANKIAAFCQGKPAVVKEMKTERKEFQPPLLFNLSSLQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFDEYKGLLPAPVESIMNNKRYVNEKKVTDHYAIIPTEQVTNPSRLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTIVTLVDERAEFISKGKQQIQEGWRKVIFQDDKDDETILPIVAEGEEGKVVKVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVKKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGTASPATFMEQTKKLSAKIIEDAVEMSEKWDFTGLHVESIERKGSKFTTGKKVGSCKKCDGDVIDKSTFYGCSNYNTTQCDFTISKKILSKTISQKNMTKLLKGEKTDLIKGFKKGEKTFDAKLEWKDNKINFVFEN
(12) DNA topoisomerase 3 [Bacillus anthracis str. CDC 684]
2
MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
(908) DNA topoisomerase III [Exiguobacterium sibiricum 255-15]
7
MQLIIAEKPKQAEKLAAPYPSVKRDGYIEIKPCDRFPAGAKLAYAVGHLCELQEPAHYDAKWKRWNYDHLPIIPERFDYRLSRGKSKTFQVIKKLLNERTTTSIIIASDAEREGEAIVRLILRLANNAKPIQRLWISSLTPQAVDHGFANLLDGKETENLFHEAMSRACADWLIGMNASRAYTTLLKKKGIADVFSLGRVQTPTLSLIVEREKQIENFRPETFFEVEADFTRYTGKYINPKKQTKITERSLAEAIVARTTGTGTVAAVEKTEQVEKPPFWFSLSLLQTEASRRFGLGAKETLDIAQKLYIRGWISYPRTDSSFVSKDEASQFPAILNRLLKQPEYTELTDLVTNNLMNNKRYVNSAKVSDHYAIIPTEEAGAVAKLSGRDAQVYDLIVRRFLAAFAADARSEKTEIITEREQDRFLTKGSRSLELGFKKVLKIEAKEQELPAVEVGQPVPIKGAKLLEKQTEPPKRYTEGTLILGMKTAGKVLENELQAIMKEIEGLGTEATRAGIIDGLKRREYIQVKKKELHPTAKGRILIEAVSGSILASPEMTAKWESRLDQIGKGEASAAQFVDQAKKLSQHLVQDAKTRVEQLEVDPTQVPAKRARGATNRPVGICPVCQAELLDRGKFYGCSAYQKNNCGFTLPKTILGARLTQTELKKMLANGKTKPLEMKKNGRTFQAMLYLEQHQLKFEFVKGEA
(567) DNA topoisomerase 1 [Exiguobacterium sibiricum 255-15]
1
MAKYLVIVESPAKAKTIKRYLGSNYTVKASMGHVIDLPKSQMGVDVEHDYEPKYITIRGKGPVLKELKTAAKKAQKIYLAADPDREGEAIAWHLAKALGVDESTECRVVFNEITKDAIKDSFKRPRKINYDLVDAQQARRILDRLVGYSMSPLLWKKIKKGLSAGRVQSVAVKMIIDREQEINAFLPEEYWTIKLELDANGEKLEANFYGIDGKKRELHSEEEVNEVLAKLSKSFTVDSVTKKERRRNPALPFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIELGKEGTVGLITYMRTDSTRTSETANLEAHGFIENAYGKEYIAVEKRKEKKAANSQDAHEAVRPTSTMRDPQLVKSYLSRDQFRLYKLIWERFVASQMAPAVLDTVKVDLVSNDVMFRANGSTVKFAGFMKVYIEDTDDETVTDVKDGLLPALEDGEVLEQEMIEPKQHFTQPPPRYTEARLVRAMEELGIGRPSTYAPTLDTIQKRGYVTLEEKKFLPTELGELVIDMISDYFQEFITVQFTADMEALLDAIEKGDMQWTEVVDPIYKSFEKRLTRAEAEIEKIEIKDEPAGEDCEVCGHAMVIKMGRYGKFMACSNFPECRNTKPIQVEIGVKCPTCGTGEIVERRSKKGRLFYGCSNYPECEFVSWDKPVEEPCPVCSSMMVQKKIKNGVKVECTSCGHHETRIDQEQEEE
(295) DNA topoisomerase 1 [Bacillus weihenstephanensis KBAB4]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKYPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREKEIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNEAQVNEIIEKMKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARDYITEAFGAEYIGTEKRKETKKSKAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTAKLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDIEPKQHYTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVALDNKRFVPTELGGIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCSHPMVFKMGKYGKFMACSNFPECRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(222) DNA topoisomerase [Bacillus weihenstephanensis KBAB4]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLNTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTEIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDEADTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYEGKWEKDNESRLNDPDLANKIAAFCQNKPAVVKEMKTERKEFQPPFLFNLSALQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFDEYKGLLPAPIESIMNNKRYVNEKKVTDHYAIIPTEQVTNPSKLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTITTLVDERAAFISKGKQQIQEGWRKVIFQDDKDDETILPIVAEGEQGKVGKVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVQKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGTASPATFMEQTKKLSAKIIEDAVEMSEKWDFTGLHVESIERKGSKFTTGKKVGNCKKCDGDVIDKSTFYGCSNYNTTQCDFTISKKILSKAISQKNMTKLLKGEKTDLIKGFKKGEKTFDAKLEWKDNKINFVFEN
(577) DNA topoisomerase 3 [Bacillus weihenstephanensis KBAB4]
2
MAKSIVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKQWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIIATDAGREGELVARWIIDKVKMQKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIASREDEIKHFKAQTYYGIEAQTAERLKLTWQDTKGNSRSFNKEKTDAIVNKISKQNATVVDIDKKQKKSFAPGLYDLTELQRDANKIFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPVKSNKSFVDDSKVSDHHAIIPTESYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKIGDETFIARGKTILHAGWKEVYENRFEDDDASDDVKEQILPRIEKGDTLNIKLIVQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLLEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVAEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGSKADKRDVQKYMKQQNKEEEPLNNPFAEALKKLKFD
(940) DNA topoisomerase 1 [Bacillus pseudomycoides DSM 12442]
1
MESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIDREKEIQSFIPEEFWTIKTEFVKGKDTFEASFYGVNGEKVQLTNEAQVKDIIETMKNNAFSVENVTKKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDIGKQGTVGLITYMRTDSTRISETAQEEARSYITEAFGSEYIGTEKKKETKKANAQDAHEAIRPTSVMRKPEELKSFLSRDQHRLYKLIWERFVASQMASAVMDTVTARLINNNVQFRASGSVVKFSGFMKVYVESKDDGAEEKDKMLPPLEIGETVFSKDMDPKQHFTQPPPRYTEARLVRMLEELGIGRPSTYVPTLETIQKRGYVALDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQNLDEVEEGKANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCGHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(1583) DNA topoisomerase [Bacillus pseudomycoides DSM 12442]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLDTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTGIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDEADTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYEGKWEKDNESRLKDPDMANKIAAFCQNKPAEVKEMKTERKEFQPPFLFNLSSLQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFEEYKDLLPAPIESIMNNKRYVNEKKVTDHYAIIPTEQATNPNKLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTITTLVDSRAEFISKGKQQIQEGWRKVIFQDDKEDETILPIVVEGEQGKVVTVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVKKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGIASPATFMEQTKKLSAKIIEDAIEMSEKWDFTGLHVESIERKESKFTTGKKVGKCKKCDGDIIDKSTFYGCSNYNTTQCDFTISKKILGKTISQKNMTKLLKGEQTDLIKGFKKNDKTFDAKLEWKENKINFVFEK
(1608) DNA topoisomerase 3 [Bacillus pseudomycoides DSM 12442]
2
MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGNKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLIRKDVTEIIVATDAGREGELVARWIIDKVKINKPIKRLWISSVTDKAIKDGFANLKPGKAYENLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAIIAGREDEIKNFKAQTYYGIEAQTTDKLKLTWQDGKGNGRSFDKAKIDTIVKKLDKQNATVTEIEKKQKKSFAPGLYDLTELQRDANKIFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKILNKPIKSTKAFVDDSKVSDHHAIIPTESYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKIGDETFVARGKTILHSGWKEVYENRFEDDDAVEDLKEQILPRIEKGDTLSVKLIAQTSGQTKPPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTAEWEQKLEAIAKGKLKKEIFISEMKNYTKEIVAEIKSSDKKYKHENISTKTCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGDGQIFACKCGYREKLSTFQERRKKESGNKADKRYVQKYMKQQQKEEEEPLNNALAEALKKLKFE
(990) DNA topoisomerase [Geobacillus thermoglucosidasius C56-YS93]
7
MKVIIAEKPDQGATLASIFQTKKHQGYIEIYPNELFPKGAYMTWAVGHLFQLVPPEWYRPEWKQWKLETLPIIPERFQYEVERAKAKQFAIVKELLRKPEVTEIIHAGDAGREGELIVRNIIHMSGVKKPMKRLWLSSLTPKAIYEGFRQLLDEAETRNLYEEAYARACADWLVGMNASRVYSILLKQKGMNDVFSVGRVQTPTLAFIVKREKEIEQFRPEPFWEVVAAFAVNGKQYEGKWTNEEGETRIKEEQLAQKIAQFCRNKLAEIHEVKTERKTFLPPLLFNLSSLQATANKMYQFSPKKTLDILQNLYQKGIVSYPRSDSNYVTKGEAETFPDILQKLRAFSDYQPFFPLPNALILHNKRYVNEKKVTDHYAIIPTEQVVDPAKLPADERKIYDLIVRRLIAAHYEAAVFDFTTVITLVDGRARFVSKGKQQIQEGWRKVISPREDDDGALLPLLHEGEQGDVLNVRVKVGKTQPPKRYTEGQLITLMKTAGKFLDNEELEKVLAKTEGLGTEATRAAIITTLKERNYIEVRKNQVYATDKAKVLIEAIGDKILASPEMTAKWEQRLSEIGEGKASAAQFMEQVKKLSAKIVQDAVEMSETWDFAGLDTASIQRTTSKAALGKPVGPCKLCGGTVIDKGAFYGCANYAKTKCPFAISKKILGKTVSRANVKKLLEHGRTGVIKGFKKEGKTFDAALVWDEKEKKITFSFAKK
(1342) DNA topoisomerase 1 [Geobacillus thermoglucosidasius C56-YS93]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDINNGYEPKYITIRGKGQIIKELKTAAKKAKKVFLAADPDREGEAIAWHLANMLELDIHSDCRVVFNEITKDAIKESFQHPRAIDMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIKQFQPEEYWTIQAEFVKGNETFTASFYGADGQKLDLKNEADVSAILRRINGNHFTVTSVAKKERKRNPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVSESAQQEALSYIEATFGKEFAAQEKRKEKKSANAQDAHEAIRPTSVFRDPEKVKPYLTRDQFRLYKLIWERFVASQMAAALLDTMSVELENGGVIFRANGSKVKFPGFMKVYVEGTDDQTDEQDRLLPDLQEGETVFSKDIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTIDTIQKRNYVVLENKRFVPTELGEIVVELILEFFPEIIDVEFTAKMEKNLDEIEEGKVQWVKVVDEFYREFEKRLQIAEKEMKEVEIKDEPAGVDCEVCGSPMVYKMGRFGKFVACSNFPECRNTKPIVKEIGVKCPKCHEGNIVERSSKKKRIFYGCDRFPQCDFVSWDKPLARRCPKCEGVLVEKKLKKGVQVQCTSCDYEEEPQS
(1299) DNA topoisomerase 1 [Geobacillus thermoleovorans CCB_US3_UF5]
1
MSDYLVIVESPTKAKTIERYLGKKYTVKASMGHVRDLPKSQMGVDIDHGYEPKYITIRGKGQVIKELKTAAKKAKKVFLAADPDREGEAIAWHLAHMLDLDIHSDCRVVFHEITKDAIQQSFQQPRAINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREREIREFQPEEYWTIQATFQKEGETFAASFYSIDGQKRDLKTEADVKAVLDRLNGTAFAVKTVTKRERKRSPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVAETAQQEAAAYIEATFGAMYVNQEKRKEKKSTNAQDAHEAIRPTSAFRDPDKVKPYLTRDQFRLYKLIWERFIASQMAAAVLDTMSVELENNGVVFRASGSKVKFPGFMKVYIEGTDDQTEEQDRILPDLEEEETVESETIESKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVVELMLEFFPEIIDVEFTAKMEKELDEIEEGKVEWIKVVDEFYREFEKRLKVAEKEMRAVEIKDEPAGIDCEVCGSPMVYKMGRFGKFIACSNFPECRHTKPIVKEIGVKCPKCREGNIVERSTKRKRVFYGCDRFPDCDFVSWDKPLARPCPKCAGLLVEKVLKKGVQVQCTACDYEERLEA
(1063) DNA topoisomerase [Geobacillus thermoleovorans CCB_US3_UF5]
7
MKVIIAEKPDQGATLASIFRTKKRQGYIEILPNDLFPDGAYMTWAIGHLFQLAPPERYRPEWKRWTLNTLPIIPERFEYEIEKAKAKQFQVVKELLRKPEVTEIIHAGDAGREGELIVRNLIRLSGVNKPMKRLWLSSLTPKAIEEGFRRLLDEQTTRPLYEEAYARACADWLVGMNASRVYSLLLKERGMNDVFSVGRVQTPTLALIVRREREIEQFRPEPFWEVVASFVIGDKRYEGKWTDKNGQTRLGDEEMAKKIAAFCQGKRAEVADVRTERKTYQPPLLFNLSTLQATANKLYRFSPKKTLDVLQSLYQKGIVSYPRSDSMHVTKGEAETFPAILQKLSSFPAYAPYFPLPQPSILQNKRYVNEKKVTDHYAIIPTEQVVAPEKLSDDERKVYDLVVRRLIAAHHQAAVIDYTTVTTLVDGRARFVSKGRQVVEEGWRAVIRPHEEEKDAALPPLERGEAGKAAAVKVKEGKTEPPKRYTEGELITLMKTAGKFLDDEELEKVLAKTEGLGTEATRAAIITMLKERKYIEVKKNLVYATDKAKVLIEALGGTILASPEMTAKWEQRLSEIGEGSASPAAFMEQVKKLAQKVVADAIAAAPNWNFRGVDTASIQRTRKKKTMGEKLGPCPLCGGTVIDKGTLYGCDQYAKTKCSFTISKRILGKSISAANVKKLLAQGKTNVIKGFKKGGKTFDAILVWDENEKKLSFQFPKR
(1298) DNA topoisomerase [Geobacillus thermoleovorans CCB_US3_UF5]
7
MKSLVLAEKPSVARDIARVLGCKQAHKHYFEGKQHIVTWALGHLVELKMPEDYDRKYETWRLEDLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIATDAGREGELVARWILEMIGWTKPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVCRAEADWLIGLNVSRALTTKYNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKIGSITAVWERHGGHRLFDQDEAKQLIARLDGQPARVVSVKRKRKSEPAPLPYDLTELQRDANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMEATMTERLLAMKSGYEDVIAPLLAKGKAKAAKRVFNDDKVTDHHAIVPTDERLNLSRLSTDERKLYDLIARRFLALFFPPYESETTTAVFDIGGEMFVAKETAVVNFGFKAVLGKEETDAKPTLSHLAEGQTLPSVQLEREQSFTEPPARYSEADLLAQMEKYGLGTPATRADIIERLVETEVVERKDGRFYPTKKGKQLIELVNEELKSPELTARWERELEAIARGKGNPQQFLANIRRQTETLVAEIKQSEQVYKAPNLTNLTCPECGALLKERKTKDGRMLVCSNLACRYRRRRDPKLSNRRCPQCHRRMEMHEGKAGMYFQCRPCNIVEKADETKRIAAKGSERALLKKYSPANESFGTSLGELLKQALNEKKE
(558) DNA topoisomerase 1 [Bacillus thuringiensis serovar konkukian str. 97-27]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEIEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(1090) DNA topoisomerase 3 [Bacillus thuringiensis serovar konkukian str. 97-27]
2
MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
(1561) DNA topoisomerase 1 [Streptococcus mutans UA159]
1
MTSKTTTTVKKTSKKRATPKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKNAKQIFLASDPDREGEAISWHLAHILDLDLKGKNRVVFNEITKDAVKNAFVEPRQIDMDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWSIDGFFKKGNKKFQANFYGLDNKKTKLKSNDDVKKVLTRIKNDDFLVDKVEKKERKRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIRLGSNGQQGLITYMRTDSTRISPVAQNDAANYITEHFGAEYSKHGNHVRNASGAQDAHEAIRPSNVNHTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLTQNGVLFIANGSQIKFKGYMAVYNDSDKTKVLPEMIKGETVKKISANPEQHFTQPPARYSEASLIKTLEENGVGRPSTYAPTLETIQKRYYVRLVSKRFEPTELGEIVNSLIIEFFPDIVDVKFTAEMESKLDEVEIGKEEWQKVIDQFYKPFEKEVIKAEEQMEKIQIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVICPICQKGQVIERKTKRNRIFYGCDRYPDCDFTSWNKPIGRDCPKSGDFLVEKKIRGGGKQVVCSNEECDYKEKAVK
(760) DNA topoisomerase 1 [Streptococcus suis ST1]
1
MATKTVSKKKTTTKKNLVIVESPAKAKTIEKYLGKNYKVVASVGHIRDLKKSSMSIDFDNNYAPEYINIRGKGPLINSLKKEAKNAKQVFLASDPDREGEAISWHLAHILGLDANDKNRVVFNEITKDAVKNAFQEPRAINLDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEISNFKPEEYWTIDATFKKGSKKFQASFYGIDGKKTKIENNEQVKEILARLDGDDFLVEQVERKERKRNAPLPYTTSTMQMDAANKINFRTRKTMMVAQQLYEGVSLGTGGTQGLITYMRTDSTRISPVAQAQAADFITERFGATYSKHGNKVKNASGAQDAHEAIRPSNVNLTPESIAKYLDKDQLRLYTLIWNRFVASQMAAAVFDTMSVRLGQNGIVFAANGSQVKFDGYMAVYNDADKNKMLPDMEQGDTVVRASTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVKLAAKRFEPTELGEIVNKLIVEFFPDIVNVKFTADMEQKLDDVEIGKEQWQKVIDGFYQPFKVELSKAEEQMEKIQIKDEPAGFDCDVCGHEMVIKLGRFGKFYACSNFPDCRNTKQITKEIGVTCPVCQKGQVIERKSKRNRLFYGCDRYPECEFTSWDKPVGRSCPKCDHYLVEKKVRGGGKQVVCPNGDYEEDKIK
(1201) DNA topoisomerase 1 [Streptococcus thermophilus JIM 8232]
1
MATATTTKTKAKKKTKAKKATKKRATPKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLIKELKKEAKKAKKVFLASDPDREGEAISWHLSHMLGLEPEDKNRVVFNEITKDAVKNAFAEPRAIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGAFKKGAKKFQASFYGLDGKKLKLNNNDDVKDVLSRIISDDFNVDKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGINLGSGAQGLITYMRTDSTRISPVAQNQAAEFITERFGSKYSKHGSKVKNSSAAQDAHEAIRPSNVFQTPESIAKYLDKDQLKLYTLIWNRFVASQMAAAVFDTMKVTLSQNGVIFTANGSQIKFDGYMAVYNDSDKNKMLPEMAEGDTIKKVVTTPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVKLVAKRFEPTELGEIVNSLIVEFFPDIVDVKFTAEMEAKLDKVEIGKEQWQKVIDEFFKPFQKELEKAEEGIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVTCPTCGQGQVIERKTKRNRVFYGCDRYPDCEFTSWDIPIGRNCPKSGDYLVEKKVRGGGKQVICSKEECDYKESVIK
(233) DNA topoisomerase 1 [Bacillus cereus ATCC 10987]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMNLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIERLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAFGTEYIGTEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(828) DNA topoisomerase 3 [Bacillus cereus ATCC 10987]
2
MSKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGRAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVMEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSKFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
(1013) DNA topoisomerase 1 [Streptococcus sanguinis SK36]
1
MSKLVTKTKKKSTTKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSTMSIDFENNYEPQYINIRGKGPLINDLKKEAKKAKQVFLASDPDREGEAISWHLAHILNLDEKEKNRVVFNEITKDAVKNAFKDPRQIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEINAFKPEEYWTIDGTFKKGTRQFQASFYGMNGKKMKLTNNEYVKEVLSHLKGDDFTVDSVEKKERRRNAPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDKFGAKYSKHGSKAKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMNVKLGQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMEKGDTVKRVNTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVKLVSKRFEPTELGEIVNSLIVEFFPGIVNVKFTAEMEAKLDDVEVGKEQWQKVIDEFYRPFEKEVAKAETEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVTCPQCQKGQVIERKTKRNRIFYGCDRYPDCDFTSWDKPVGRNCPKCDHYLIEKKVRGGGKQVVCSNGDYEEEKVK
(545) DNA topoisomerase 1 [Lactobacillus gasseri ATCC 33323]
1
MPTKRKNKKNLVIVESPHKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGVDVEHDYEPKYISIRGKGDTIKELKSEAKKAKYVYLASDPDREGEAIAWHVAHALNLDPKEHNRVAFNEITKDAVKNAFKNPRTIDMDIVDAQQARRVLDRLVGYSISPILWQKVKKGLSAGRVQSIALKLVIDRENEIKNFKPEEYWTIDADFEKGKEKFKGAFYGIKGKKQDLPNNEAVQDILKQIDKRKNFEVTKVVKKERRRQPAAPFTTSTMQQEANKRLGYRTRRTMRIAQSLYEGVNLGKGSVGLITYMRTDSKRIANVAKHEASKFIHEEYGANYAAIKPQHFKNDADAQDAHEAIRPTSAFRTPASVKEYLTTEEYRLYTLIWSRFIASQMTPAVYDTVRADIEQNDVTFRTTGSKLKFAGFTKVYDNQKEKNNELPELNEGDKVKLKKTDDRQHFTQPPARYTEASLVRALEENGVGRPSTYAPTIDTIQKRYYVKLEGRSIVPTELGEIVDKLIEEFFPDIVNVDFTAQLEDDLDGVEVGKKNWIKVVDEYYKPFSKELDKADQQIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKVGVTCPKCGKGEVIEKKSKRNRKFYGCSRYPDCDFVSWDQPIGRNCPNDGHFLVQKKNKKGLVILCPNGDYREEPEEN
(1488) DNA topoisomerase [Streptococcus infantarius subsp. infantarius CJ18]
3
MKYLLLAEKPDQAKKYANALGNPKKDKGVWRVQSSVLNAEVIVAPAVGHLVERINPYTNFENWEMANLPALPDGFAYEPKKDTAKRFKAIKQSVKEVDAIIIGTDPDREGEAIAYRILELIPGALRKIKYRLWANSLTKKGLEQAFSKLKNPKDSINYFHEADARGDADWLVGFNLSPFVTIKMKEEGYLDKKEHSMSVGRVQTPIVSLVVRNDEAIENFKPSPYWQLKLIDPEAKVTFGNDIKYQSKAEAEQMLQQLANIAVVKTVTSEEKVQEAPELYNLTNFQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFAYLVEHIEDYQKAINKHLETPNRSPRKNYVNDKKVLEHYAIIPTETIPDLSELSNDEKLIYQKVVFRTLLMFTPDYRYQSTSVILDNQGLEFKATGAVTKDKGWRNYLAVKKEDKELPDYQEGQTITIECKLLEEMTKPPTRITEQILLKKLLPKYNLGTSATRDGMIDLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVNKIKWAITKQIEKGKQL
(263) DNA topoisomerase 1 [Streptococcus infantarius subsp. infantarius CJ18]
1
MATTTTKAQTAVKKTSKKTTKKKTAAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINDLKKEAKKSKKVYLASDPDREGEAISWHLAHILGLDENEKNRVVFNEITKDAVKNAFVEPRQIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIRNFKPEEYWTIDGFFKKGTKKFQAAFYGIDGKKLKLSTNEEVQEVLARLTSDEFNVAKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGISLGKSGTQGLITYMRTDSTRISPVAQNDAAGFITERFGENYSKHGNRVKNASGAQDAHEAIRPSNVNLTPESIAKHLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVNLEQNGVRFTANGSKVKFDGYLAVYNDSDKNKMLPDMVEGDVVKKVSTSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVRLVSKRFEPTELGEIVNNLIVEFFPDIVDVKFTADMEGKLDEVEEGKEQWQKVIDAFYKPFEKELAKAETEIEKIQIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVTCPICGEGQVIERKTKRNRLFYGCDRYPECEFTSWDKPVGRSCPKCGQFLVEKKIRGGGKQVVCSSEECDYEEAKVK
(1599) DNA topoisomerase 1 [Streptococcus mitis B6]
1
MATATKKKKSTAKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTIDGVFKKGTKQFQASFYGVDGKKLKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDYDKNKMLPDMAVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVDYFPDIVNVTFTAEMEGKLDDVEVGKEQWQRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCSSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPDCEFTSWDKPVGRDCPKCGHFLMEKKVRGGGKQVVCSKGDYEEEKIK
(1763) DNA topoisomerase 1 [Streptococcus oralis Uo5]
1
MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILDLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEINAFQPEEYWTIDGVFKKGTKQFQASFYGMNGKKMKLTTNEEVKEILSHLTSKDFTVDQVDKKERKRNAPLPYTTSTMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASYINDRFGSKYSKHGSKIKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTGAIFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMAVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWQRVIDAFYKPFSKEVAKAESEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGNSMLVAISQTAVTHKLLSKRLESSVQAVIKDKSSNEKPSVIVSSMVAIAIQNVNLLPGTNQLDVIVQNADTSLWRKRSVAVVNRLYVVMATTKKRKLNNTKSPENKFQALFT
(240) DNA topoisomerase 1 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
1
MGTKTTTKPKTGTKKSTTKKKSAAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHILGLDPEDKNRVVFNEITKDAVKNAFVEPRQIDMNLVDSQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFVPEEYWSIDGLFKKGTKKFQASFYGLDGKKMKLSNNDDVKAVLAKLKGDDFLVSKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIHLGENGTQGLITYMRTDSTRISPVAQNDAAQFISNRFGANYSKHGNRVKNTSGAQDAHEAIRPSSVNHTPEAIAKYLNKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLEQNGVLFVANGSQMKFDGYMAVYNDSDKNKMLPEMEEGETVKKVSTSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVAFTAEMEGKLDQVEIGEEEWQHVIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGHPMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPICHKGQVIERKTKRNRIFYGCDRYPECDFTSWDLPVGRDCPKSGDYLVEKKVRGGGKQVVCSNETCDYKEEKIK
(1809) DNA topoisomerase 1 [Geobacillus sp. WCH70]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDINNGYEPKYITIRGKGPIIKELKTAAKKAKKVFLAADPDREGEAIAWHLANMLDLDIHSDCRVVFNEITKDAVKESFQHPRPINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIKQFQPEEYWTIQAEFVKGNETFTASFYGVDGQKLELKKEADVAAILQRINGNHFTVTSVAKKERKRNPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVSESARQEALSYIEATFGKEFVAQEKRKEKKNANAQDAHEAIRPTSAFREPEKVKPYLTRDQFRLYKLIWERFIASQMAAALLDTMSIELENEGVIFRASGSKVKFPGFMKVYVEGTDDQTDEQDRLLPDLQEGETVFSKDIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVLELMLEFFPEIIDVEFTAKMEKNLDEIEEGKVEWVKVVDEFYQEFEKRLQTAEKEMKEVEIKDEPAGVDCEVCGSPMVYKMGRFGKFVACSNFPECRNTKPIVKEIGVKCPKCREGNIVERSSKKKRIFYGCDRFPQCDFVSWDKPLARPCPKCGGLLVEKKLKKGVQVQCTACDYEEAPQS
(860) DNA topoisomerase 1 [Oceanobacillus iheyensis HTE831]
1
MSDYLVIVESPAKAKTIERYLGKKYTVKASMGHIRDLPKSQTGVDVENNFTPKYITIRGKGDVLKELRKAAKKAKKIYLAADPDREGEAIAWHLAYILGVDPSSNCRVVFNEITKEAIKESFKHPRAIDLDLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALKMIIDREKEIQNFKPEEYWSIDAKFQKDKEIFDGSFYGINGKKVALKNEQDVKDIKQQLNGKKFAVDKVKKRERKKNPALPFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKKSGGITGLITYMRTDSTRISNTAKDEAKNYIVDNYGEKYLGKQASTKNKEGAQDAHEAIRPTSALRDPKNLKNILSRDQFRLYKLIWERFVASQMAPAVMDTMTVHLLNNNIEFRATGSKIKFKGFMKVYVEGNDDNKKTEDKLLPELEEGMEVDSKEIKPNQHFTQPPPRYTDARLVRTMEEIGIGRPSTYAPTLDTIQRRGYVTMDNKRFIPTELGEIKCDLMIEFFPEVVDADFTAKMEDDLDSIEEGNIEWKQIIDSFYKDFKVRLDKAEDEMEKVEIKDEPAGIDCENCGHEMVYKMGRYGKFLACSNFPECRNTKPILKEIGVDCPKCEEGNVVERKSKKKRTFYGCDRFPECDFVSWDKPIARKCPKCESMLVEKKNKKETQVQCTNCEYKEVAQT
(400) DNA topoisomerase 3 [Oceanobacillus iheyensis HTE831]
2
MSKTVVLAEKPSVGRDIAKVLGCHKKGNGFLEGSKYIVTWALGHLVTLADPDMYDSKYKTWRMEDLPMLPDHLKLVVMKKTGKQFQSVKTQLNRQDVVEIVIATDAGREGELVARWIIEKARVKKPIKRLWISSVTEKAIKDGFKQLKPGKNYWNLYQSAVARSEADWYVGLNATRALTTKHNAQLSSGRVQTPTLEMVSLREQEIKNFQPKKFYQLEAKTTKGHRFLWKNDENQNRIFSKNEAIKLEEKLSNKQATVVHVDKKLKKKHAQGLYDLTDLQRDANRIFQFSGKQTLSVMQKLYEQHKLVTYPRTDSRHLSTDIVSTLKDRVKACGVDEYAKIANTILNKELRLNKSVVDNAKVTDHHAIIPTEVPVVWTALDDKEKKIYHLIVQRFLAALSDPMEYEQTTITIDIAGEQFIANGKVTKRLGWKEIYKHNDEEDEIQPLNVTKGSKLTLKVELKEGETKPPERFTEGTILQAMENPTRYMGTNKKELVDTIKETGGIGTVATRADIIEKLFMNSYIELKGRNIYLTQTGRQLLDLAPEELRSPLLTAEWEQKLSLIAEGKLKKDQFIKEIKSYTKEAVTEIKQSSETFKHDNMTGTKCPKCGKLMLEIKNKHGKKLVCQDRSCGGKKNIAKFTNARCPNCHKRLELRGEGEGQIFTCKCGHREKLSTFQARKEKEKKQRVSKKDVKKYLNKQDEGFKNNALADALAKLKNDE
(1827) DNA topoisomerase 1 [Helicobacter felis ATCC 49179]
1
MGKNTKLIIVESPTKAKTIAHFLDNSYEVIASKGHVRDLSKYAMGIKVQDNKFIPKYAIDKDHEEIVAQILQKAKNAQEIYIATDEDREGEAIGYHIAYLIDQAGNRSKDPLIEMRALEEQSQTKNPHPIFAFPRIVFHEITKTAILHALKHPKTLDVHKINAQLARRLLDRIVGFSLSSLLASKISKGMSAGRVQSAALKLVVDREREIKVFKPIIYYEITGTIAQASVSLQSYRHEKIKKQGLRDSKEALEMVANLSAQTYQVQEISTKEKNTPSPPPFMTSTLQQSASNQLGYSPSKTMSIAQKLYEGVMTSEGVSGVITYMRTDSLNIAKEAIESARVFIEQTYGAPYVPKKPKVYTSKNKSAQEAHEAIRPTNLAFTPAIAKDYLKPEEHKVYTLIYQRFLASQMSDARLESQSVSFACESLGAVFKASGHKLLFEGFYKVLGNGDKDTLLPSFTLHQEVRLEKLEAKECSTQPPARYSEASLIKTLESLGIGRPSTYAPTIALLLSRDYVSLQQKQLTPTPNAFSVIEILEKHFSEIVNATFSAGLEDKLDAIASHELNWQDMLLKFYTPFMAQIEEGKIQIASQKVSAPTGESCPKCGAPLVQRTGRYGVFVACSAYPKCKFIKSEVVQTEDLGVCEKCGAPMVSKRGRFGTFVACSAYPTCKNIRNEESKNTPALAKCPQCGGDVRAKRGKRGMFYGCDNYPSCKFISNYKPAPKPCPECGGLCVMKIYKTKPSVQECLQCHIQVEIEGEQV
(180) DNA topoisomerase 1 [Clostridium sp. BNL1100]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAVKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATKMICDREDEIENFESQEYWSITAKLTKPKASPNFEARFYGIGKEKIELTNEEQVNSILDEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGFTTKRTMMVAQQLYEGIEIKGHGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPENPRVYKNKSASQDAHEAIRPTYMDMAPEGLKEFLSAEQYKLYKLIWDRFISSQMSSAIYDTVAADITAGKYMFKANGSKVKFPGFMVLYIEGNDVEGKDEDGEQNEKENNLPQLNEGDILELKKNTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAQMESELDDVEDGNKEWKAVMRDFYSSFAGVLKEAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNTKPIVEEAGVECPLCKGKVLIKKTKKGKKYIGCERNPECSFMSWDMPSPNKEMCPVCGAFMLQKSSGKKKALKCSNDKCTSNTETSTDTK
(250) DNA topoisomerase 3 [Clostridium sp. BNL1100]
2
MGFTLVIAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFSVQWQDGRTNQTRTFNKEEADGIVAKITGQIGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKISVTKRFVDNSKVTDHHAIIPTEQFVDLSSLNSEERNIYDLIVKRFIAVLSQPFEYEQTTVKLNVAGESFYAKGKIVRSSGWKTVYDGFGKLDEDSDEDDNDQSLPDIQKGHKAKVVAPKAINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERRGKEIYPTSKGTQLISLVPADLKSPELTAKWEQQLSLISKGKANSNAFVGEMKNYAKKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHVCPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGEQVDKKDVARFMRQQDKDESINSALADALAKWKK
(922) DNA topoisomerase 3 [Tepidanaerobacter acetatoxydans Re1]
2
MSKTLVLAEKPSVARDIARVMNCGKNGNGYLEGQKYIITWALGHLVTLAEPEAYGNRYKSWRMEDLPILPKDLKLEIIKQSRRQFNIVKEQMNRNDVNSIVIATDAGREGELVARWIIKMANVKKPIKRLWISSVTDKAIRDGFNNLKDGKQYENLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAMIAKREEEIQNFKPRDFYGITATVGNLKLVWQDSQTRDIRTFDKGKIDRILASLRGKNAEVIDVTKTLKKSFAPQLYDLTQLQRDANKIFGFSAKETLSIMQRLYENHKLLTYPRTDSRFITTDIVATLEDRVKACGVGPYRTAAFKIKRPIKGNKSFVDNGKVTDHHAIIPTEQPAFLDSLSENERKIYDLVVKRFLAAMYPPFEYEQTTIKAKIGTEIFIAKGKTVIALGWKEVYEGFDDESSEDENLNDGIFEQILPTMSKGDILKITSIFQTQGRTRPPAPLNEGTLLAAMENPVKYMPKDNKDLIKVIGETGGIGTVATRADIIEKLFNSFLIEKRGKDIFITSKGRQLLDLVPEELKSPALTAQWEQKLSAIAQGALKKDTFVNDMKNYAKRAVQDIKNSEDKFRHDNLTRSKCPQCGKYMLEVNGKKGKMLICQDRECGYREKLSKVTNARCPNCHKRLELHGEGEGQIFICNCGYREKLSAFNERKASEGNNKVSKRDVAKYLQKQKKDEDKPINTELADALAKLKL
(1026) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(921) DNA topoisomerase 3 [Tepidanaerobacter acetatoxydans Re1]
2
MSKTLVLAEKPSVARDIARVMNCGKNGNGYLEGQKYIITWALGHLVTLAEPEAYGNRYKSWRMEDLPILPKDLKLEIIKQSRRQFNIVKEQMNRNDVNSIVIATDAGREGELVARWIIKMANVKKPIKRLWISSVTDKAIRDGFNNLKDGKQYENLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAMIAKREEEIQNFKPRDFYGITATVGNLKLVWQDSQTRDIRTFDKGKIDRILASLRGKNAEVIDVTKTLKKSFAPQLYDLTQLQRDANKIFGFSAKETLSIMQRLYENHKLLTYPRTDSRFITTDIVATLEDRVKACGVGPYRTAAFKIKRPIKGNKSFVDNGKVTDHHAIIPTEQPAFLDSLSENERKIYDLVVKRFLAAMYPPFEYEQTTIKAKIGTEIFIAKGKTVIALGWKEVYEGFDDESSEDENLNDGIFEQILPTMSKGDILKITSIFQTQGRTRPPAPLNEGTLLAAMENPVKYMPKDNKDLIKVIGETGGIGTVATRADIIEKLFNSFLIEKRGKDIFITSKGRQLLDLVPEELKSPALTAQWEQKLSAIAQGALKKDTFVNDMKNYAKRAVQDIKNSEDKFRHDNLTRSKCPQCGKYMLEVNGKKGKMLICQDRECGYREKLSKVTNARCPNCHKRLELHGEGEGQIFICNCGYREKLSAFNERKASEGNNKVSKRDVAKYLQKQKKDEDKPINTELADALAKLKL
(1025) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(1328) DNA topoisomerase 1 [Clostridium ljungdahlii DSM 13528]
1
MGQKLVIVESPAKAKTIGKYLGKNYVVKASMGHVRDLPKSQLGVDIDNEYTPKYITIRGKGELLDKLRKEAKKSEKVYLATDPDREGEAISWHLSHALKLDENEKCRIEFHEITKNAVKSSIKSARLININLVNAQQARRVLDRLVGYKISPILWRKIKWGLSAGRVQSVALKMICEREKKIVDFVPQEYWTIECELHKENESKCFNVKLTTFNKKKIEIGSKDEVDKIIEELKQGQFIVKSIKNTNKNRTPLPPFTTSTLQQDAYKKLNFSTKRTMSIAQQIYEGVDIKGYGTIGLITYMRTDSVRIAQEAQEACRDFVANKFGKEYIEEKPRNFKSKKNIQDAHEAIRPTNVEITPEIAKENLKPEQYKLYNLIWNRFVASQMSSCQIDVKSIDIVNSNYGLKVSGSRIKFDGFMKVYKYATEEEKSDISLPKLEEGEKLLRKSIDGKQHFTQPPARFSEASLVKTLEENGIGRPSTYAPILSTLLDRKYIQREKKTLIPTELGDIVNNIVSQYFKQVVDVEFTAAMESKLDSVEDGKDDWRKVVGEFYEPLKKSIEIAEKEVARITIEDKVTDIKCDKCGRNMVIKHGRFGDFLACPGYPECKNTKPIVEELDVKCPKCQGKVLIKRSRKGRKFYGCSNYPDCDFVSWFEPTNEKCKECGNYMVKKYNKSKGNYLECSNSECKHREYKAVEDGDEKTAK
(151) DNA topoisomerase [Clostridium ljungdahlii DSM 13528]
3
MKSLIIAEKPSLAMSIVKSIGSMERNNGYFENKNYIVTFAYGHLLQLYDVDDYFGREKTKWTLKELPFVPKEFKFRLRKDEGVKKQYEIIKSLIKRNDVQEIVNCGDADREGEVIVNNIIFRAFEEEHVTKPVKRLWLPEQTRQTIIQSLKDLRDDIEYKNLYDEGLARTYLDWSYGINLTRYLSIKSGSFLPVGRVLIPIVKYVYDRDEKIENFKPETYFEIGAVINKDNLHIKTKLKDRKFAANERDKAEKLLNNLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKEEKMSLDDTLKNLQKLYEAGYTTYPRTNTEYLAENEKDRIKSVIAAVKENFNADISFKDNKKIFNSKKVESHSAITPTIKIPRKEKLSEGEKKVYTAIKNRFISNFLNEETIIEETSVVIKIDDEIIQLKGNVIKSPGFLKYEKSKRENELPQFVEGEELDTKLSVDQKETQKPGRVTESELNNFLKNPFKKQEVEDLEGENDDEEYKLILEGCEIGTVATRAGIIKNAKKYEYIKELKGHLECENKGKKLIEALEKLKIDLNKEKTVEFGKQLKKVYKEEIGINEIIDKVKDELNSIVQNGNKIKIEKLYLYNNKSDSKIKIESIGKCPVCHEGEVVENKSGYGCNRWKEGCKFFVGNKIAGKEILKTHVKKLIKDSKTNVIKGFKGKSGKKFNASLVIDKEGKIVFNFENEVLGKCPCCGHDIVEGKNAFGCSNWKEGCKFTIWKNDKYLACMGKKPTKTMVCELLKNGKVKIKGLKGKDGNIFDAYLMLIKNENENKDKYPYKWKMQITK
(22) DNA topoisomerase 3 [Clostridium ljungdahlii DSM 13528]
2
MGKILVLAEKPSVGREIARVLKCRKKGNGWLEGEKYIVTWALGHLVTLADPEAYDDKYKTWKLEDLPMLPKYLKLVVIKQTGKQFNAVKEQLNRKDVTEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAINEGFRNLKPSSQYDNLYRAAQCRAEADWIVGLNVTRALTCKHNAQLSAGRVQTPTLAMIVHREEEIKNFKPKDYYSIIGNANGYTLQWQNGNGHFNTFDENFANKVVSKVNGQNGKILDVIKSDKKKYAPALYDLTELQRDANRLFGYSAKQTLSIMQRLYENYKFLTYPRTDSRYISADIVPTLPERLKAISVGNYSKFAMEIMRGKIRAHKGFVDDSKVSDHHAIIPTEEKVILSKLSNEERKVYDLVVKRFLSVMLPPFEYVQTTVKAEINGENFAASGKVIKSKGWKAVYDKNEDFDDNDGLHENQLKEQVLPNLNRGDSIKLTAVKMHKGQTKPPARFNEGTLLSAMENPQKYINMNKEYAKTLGETGGLGTVATRADIIEKLFNTFYIEKKGKEIIPTSKGKQVVELVPEDLKSPLLTAKWETDLNLISKGKLNDKSFIGNMRNYSVKLVEDVKGSHDKFRHDNLSGAKCPECGKYMLEVNGKHGRMLVCQDRACGHRENLAKLTNARCPECHKKLELRGHGDGQVYVCINNNCNFREKASSFNKRFDNKQGKNSKRDVANYMKKMKKESEVPMNSALADALAKLKLK
(478) DNA topoisomerase 1 [Ammonifex degensii KC4]
1
MKHLIIVESPAKARTLSKFLGSQFLVKASMGHVRDLPKSELGVDLENGFTPKYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWHLCHLLGIPPETPCRVEFHEITKNAVLNSLKSPRPIDLNRVNAQQARRVLDRLVGYGLSPLLWRKVKRGLSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLARLARFKGKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQEANRRLGMRLERTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIKEHYGAEFVGDVPPKERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLIWERFLAAHMAPAKYFLTRAEIEVGDYTFYATGRQLLFPGFLRLWRPEEEEEEGKLPPLREGEVLTFQEFVPQQHFTTPPPRYTEGTLVKALEEKGVGRPSTYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLKEHFPGIVDVGFTAAMEEKLDLVEEGQADWVDILREFYQSFSQDLVRADAAIEKVSLPDTFTDISCPRCGCPMVKKTGRYGEFLACSGYPECQMRMPVGTGVKCPRCGGELVKRRSKKGRYFYGCNRYPECNFVVWSEPVPEPCPECGSLMVRRGRGKKKRVICTNESCGYQRLEE
(982) Reverse gyrase [Ammonifex degensii KC4]
6
MELFLLAHGCPNCSGSVTDERLAAGLPCPQCLPQAGNNLSLAAVCCALRKENKIRELSPFCRAEEGLKEFELFFRQVTGLNLSPLQRLWAKRFFLEEPFAIIAPPGVGKTTFGLTVSLYNPQKSLILVPTRLLVWQVAEKLSHFAEKAGSKKKILSMTGKAKEKKELMQSEYDILVATTQFFYRHWSEIASHPITLVFIDDVDALLKSSRQVDSLFYFLGYSPEEVERALRSPEGEPREAGKRPQRLLILSSATLKPRTNRVRLFQRLMGFSVQRAVSTQRRVVDCYEEVPDFARALARAAELVRQLGPGGLVLVSPEEGREGVKEATAYLQAQGIEAESYLELTPEELVSRLAEGSLEVAVGLAHPTNPLVRGLDLPHVLKYVIFVGAPSHFFPLDLSPAPGALHGLGLALFPLFTPEEQRQVLRELRYLRPYLNLPADAVSRYPALEKRVQAFASFLKEKLKDPSFWEKIRAAEDLNLREEEGKLYLVLGDATTYLQASGRVSRLTAAGLTRGLAITLCTERRVLLSLKKRLRALTPAEIEFIPLQEVDLAGVMRGIEEDRRRIKAGELADKEGPRTALVVVESPHKARTIASFWGKPGIRRVKGVLAYEIPADERHLIITASLGHVFNLSRQQGFFGVLTFNHHFLPVFDTIKIYRETGEELVDPEEVARYPEGTVWDKQEILRGLQHLAFEVDEVYIASDPDAEGEKIAYDLYLSLRPFNPHIYRLEFHEVTPSAFRRALENPGQVNLYRVQAQLTRRVLDRWVGFCLSRRLWQKFGNRHLSAGRVQTPVLGWVVARAEEGRQRKARLTFSLGEATFTLEVPDRELGQKIFGELEKLSWEILEISEEERSPLPPFTTDTILTEAAHRLRLSAPVTMKLLQELFELGFITYHRTDSTRVSETGRFLVAKPFILQHYGEELFHPRSWGEGGAHEAIRPTRPMTEAELRWMVGAGLVDLSQERALELYGLIFRRFMASQMAPARVRKAKVRFRVPSYAWETEVVVEQIAPGFALLWPNFSVTELRPEARLTGKEYRELPLAEPYTEGTLVQEMKRQGIGRPSTYAEIVATLLNRGYLVVRGGRLYPTRLGFKVYRYLKENFPEYADTALTREIEAAMDLIAEGKEDYQEVLQKLYKVREILA
(546) DNA topoisomerase 1 [Halanaerobium hydrogeniformans]
1
MAKKNKNLVIVESPAKAKTIAKFLGRNYKVKASMGHVIDLPKSKMGIDIENNFEPNYITIRGKGKTLAKLRKEAKKSNEVYLATDPDREGEAISWHLSHALKLSEEDNNRIEFNEITKNAIKNAIKKPRQIDKNLVDAQQARRLLDRLVGYRLSPLLWKKVRKGLSAGRVQTIAVKLICEREEEIRNFEEEEYWTIDVDLKKDKDKLTASLYRIDNKKYNIDSEEAANKIVSDIKKEDFEIIKVKKRKRRRNPKSAFTTSTLQQTASSKLNYSAKKTMYLAQQLYEGMDIGSSGSVGLISYIRTDSTRLSEEAKAGAAKYIEAEFGDKFLRSKKKKKKKNKNSQDAHEAIRPTDTMRTPDKMKKHLSKDQYKLYDLIWRRFVASQMSPALYESISAQFKAGEKYKFRVSGSRLLFPGHLILTGKAKEDKIDLPVLKEGDVYKLQDVKPEQHFTKPPARFSEASLVKTLEEEGIGRPSTYAPTLSTIVSRDYVEKDGRYLKPTELGETVTELLSEYFPDVTDVEFTASLEQRLDEIEKGNEDWKKLLKDFYQPFYERLEHARENMERVQIVEETDEVCEVCGKPMVVKYGRYGKFLACSGYPDCKNTKPYLIKTGVDCPECDDGEVIERTSKKGRTFFGCSNYPECNFMAWNKPVEKPCPECGGVMVEKTTKAKGEHYKCINKECGHTEKAE
(1037) DNA topoisomerase 1 [Clostridium tetani E88]
1
MIMGQKLIIVESPAKAKTIGKYLDKTYHVEASMGHIRDLPKSQLGVDIDNNYEPKYITIRGKGELLTKIKKHAKKCDEIYLATDPDREGEAISWHLSQALKLEDNKKCRIVFNEITKSAVKNAIKEPREIDIDLVNAQQARRVLDRLVGYKISPILWRKVRWGLSAGRVQSVVLKMICDREKEIEEFIPKEYWTIECKLNKDRKDFLVKLISKDNKKIEINTEEESNNIIKELKQGQFTVDKIKKTNKNKNPLPPFITSTLQQDAYRKLNFSTKKTMSVAQQLYEGIDIKGHGTVGLITYMRTDSVRISKEAQNKARQFLENVYGKEYIPEKPRDYKGKKNIQDAHEAIRPTNIEITPKIALENLNSDQYKLYSLIWNRFMASQMAACVMEVNSVDVKNSEYIFRATGSIVKFDGFMIIYEYLNEDEKENINIPKLEKGELLKEKSIDSKQHFTQPPGRFSEASLVKVLEDNGIGRPSTYAPIISTLLERTYIERENRTLKSTELGVIVNNIMVEYFKPVVDAEFTAEMENKLDSIEEGNENWKNTVDEFYSPLKELIETAEKEVEKVTLEEKVTDVKCEKCGNNMVVKHGRFGDFLACPGYPECKNTKPIVHQLDVKCPKCHGEIVLKKSKKGRKFYGCSNYPKCDFVSWFEPVERKCDVCGNYMVKRYTKAKGDYIECSNKECKHKIMPEKKQE
(405) DNA topoisomerase 3 [Clostridium tetani E88]
2
MGKTLVLAEKPSVGREIARVLKCNKNSRSYIESNKYVVTWALGHLVTLADPEVYDNKYKKWEMETLPMLPKYMKLCVIGKTSKQFNEVKKLMNRNDIDEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAIIDGFNNLKPGKDYENLYKSAVCRSEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLALIVEREEEIKNFKPRDYYNIVAKTKGIQFNWQDKKGQMATFNEDFANNILAKVSGEIGNVTEVIEKDKKQYAPALYDLTELQRDANRIFGYSAKETLSIMQRLYENHKVLTYPRTDSRYISKDIVATIPQRLKSISIGIYSKFAEEILRGKIVAHKGFVDDSKVSDHHAIIPTEERVKLSNLSGDERKIYDLVIKRFLSVMLPPFEYIQTTIKVEVNGEVFIAKGKNIKHNGWKAVYNKEDLNEDNNDGDGLKEQVLPQIIKGDAIKFNLVNINKGQTKPPARFNEGTLLSAMENPQKYIKLNKEYAKTLGETGGLGTVATRADIIEKLYNSFYIEKKGKEIIPTSKGKQIIDLVPQDLKSPILTAEWEKKLELISKGKISGKEFINNMRNYSTKLVQDVKNSNEKYIHNNLTGTKCPNCEKYMLEVNGKRGKILVCQDRECGYRENISRFTNVRCPECHKKLELRGEGEGQIYVCSKCTFREKLSSFNKRFKEKGNNADKREVSRYMKKMKEQDKEPMNSALADALAKLNLK
(1761) DNA topoisomerase [Clostridium tetani E88]
3
MNLAKVIIAEKPSVAKNIADALNIKTRKDGYFEGKEYLITWAFGHLLQLYDAKDYNEIMKGWRLEKFPFIPMNFKYKIKQQNNNKNITDEGAEKQINIIKSLIERENVEAIISATDLDREGQIIGDELFSYLQIKKPIYRLLLNEWTPDEVKNGMKNLKCNEDMKFLRDAGISRQWSDWIIGINLTSVATLKYNIEDNKILNIGRVILPTLKIIYDRDKEIENFKATTYYKLLANFKTKKDKEFEGTYYEKNSEKFQDKSYLKIIEDLLKNKTYNIVDKHVEKKKEYAPYLFNLSNLQGYVTSKYKGWTSDKVLKVAQSLYEKKFITYPRTSSSVLDESLEGRAKKVLETLKKGLSYENQIRFNKSKRIFDSSKVESHSAITPTYIKPSKLTRDEEIVYIAIKNRFIMQFMPIAEFEETKITIKANDEDVKGEFLSKGKVQIVEGWRIVEKIETKDTILPLVEVKEKVDAVNSKIKTVTKKPPKHHTEKTLLRVMETCGKSFKDDENSEEMMNAILSGFSIGTAATRADTIKKLKDIGYIEAKGKSLICAPLGRTMIEIFPVKELLDLEYTGKLEKTLSDIEKGKFGKKEFMDLIYEFTNRAVELIKSDNSMLNKIKINLPEGVENLGKCPQCGNPVIEGSKGYGCSNWKNGCKFTIWKNDKYIQSFGKKVTKDMVKILLEKGRVGFRNLKSKKGNVFTAYFTYENNKEKGYYSWKMHFIN
(557) DNA topoisomerase III-like protein [Clostridium perfringens str. 13]
3
MKKVIIAEKPSVARNIADAFNIKKRKDGYFEGEEYLITWAFGHLLQLFDAKDYDENMKGWRMEKFPFIPEVFKYKIKQDSLNRNIIDKGAEKQIKIIKGLIDREDVDGIISATDFDREGQVIADEIFLYFSEKKPVYRLLLNEWTPDEVKKGMEKLKPNEEMQSLQDAGIGRQWADWIIGINLTSVTTIKYKLNDGQILNIGRVLLPTLKIIYDRDKEIENFKSSAYYKLNGTFKTSKNEEFEGTYYENNSEKFEDKKVLDEIKEKIKDKNAEIIEKQTERKKEYPPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKFITYPRTGSMALEESLVDRTRNVLEKLKVGLPYEEQIKFVQNKRVFDNSKVESHSAIVPTYMKPNNLTQDERIVYTAVKNRFLMQFMPVAEFEETKITSKINDKEVKGVFISKGKVQLIEGWRVVEKIDSKDTILPMVNEKEIVDLVDSKINKVTKKPPKKHTEKTLLRVMETCGKSFKEDAEEDSEEMMASILSGFSIGTPATRAETIKKLKDVGYITTKGKSLTCTELGRTIVEIFPVKELLDLEYTGRLEKTLSDIERGKVKKEDFLNLIKNFTIEGVKAIKNDDSMAKHFKVEAPEGVEVLGKCPNCGNPVIEGERGFGCVNWKNGCKYTIWKNDKYIASFGKQVTPQMVKLLLANGKVGFRNLKSKKGNTFAAYFIYEKDEEKGYFTWKMEFI
(1152) DNA topoisomerase [Clostridium perfringens str. 13]
3
MKKLVIAEKPSLAMNIVKALNSSESFERKDGYFESENYIISFAFGHLFKLYNIEEYTGEDKGAKWRNDILPFIPKEFKFSIKDDVGVKKQYKILEELIKSNRVDEIVACGDADREGEVIIRLIINNVFNNNSINKKVTRLWLPEQTTQSILYGLNNLKDIDTYNNLANEGFTRTFLDWLVGVNLTRYVTVKSKHLFPVGRVLVPIVQAIYERDKSIENFVPETYYQIESNEKTNDEIIKLVVKELAFTKSEFIKAKSFADELNTYEAIVISKDTKKVKKQPSKLFSLSKLQSLLSKKYKMTFKESLELIQKLYEKGFVTYPRTNTEYLAEAEKGKVKEIIDILCSEGYNLEFKDKKTIFDDSKIESHSAITPTVKIPKEDELKGKMLDVYNTIKNRFISNFLIEETLIDRTIIRIEVGDLEFSLKGDVIVQKGFLEYEPIKKDENTLPNLNVGDKINTNFKAIEKVTQAPGKMTTEMLSNYLKNPFKNYEIENEEEDYKAILDGLEIGTEATRTGIIENAKKYKYISENKSVLSIEPLGRKLIETLDKLNVNLSKEKTVEFSRILKKVYKNELNIDRAVDLISNELKSILEDSKNIEIEAIKEEKEVIGKCPRCGKNIYETSKSFSCEGYKDEPKCQFNIWKEDKFFKDKGKKVTKSIAKNLLAGKKVKMTGLKKKDGNGTYDAFVSLNDTGKYVNYKLDFSK
(735) DNA topoisomerase [Clostridium saccharolyticum WM1]
7
MKLVLAEKPSVAMSLSKVIGANQRGDGYMEGNGYIVSWCVGHLVELSQPEAYDEKYAKWRYDDLPILPEHWQYQVSTSTKKQFGILKKLMLRKDVKSLICATDAGREGELIFRLVYHQCGCKKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCRERADWIVGINATRLFSCLYGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKFRDFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTSLQREANRQLGFTAQQTLDYTQALYEKKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSFQIQPDVPAPVNAAQVINSKKVTDHHAIIPTKTAAGHDISSLPSGEQAILIMLAVRLICAVGTPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGRSSEDAEKNAEACNLPELSEGMTLELAGVDLKEGKTSPPKRFTEDLLLSAMESASSDEFPAGVERKGIGTPATRAAIIEKLVQKGFIERRGDKKTKYLCSTDKGNALVTVVPEQIQSPSMTADWEEKLLKIEHGEYDSDAFMGEISSMVNGLVKTYEAVKGADVLMQPERKVIGSCPACGSDVCETVKGWFCRDKSCKFALWKENRFFQTLGKQMTEELAKQLVNQGKARLTHCYSRKSNRYYDTTVRVETGEDGAAAFKLEFGGKK
(89) DNA topoisomerase 1 [Clostridium saccharolyticum WM1]
1
MANCLVIVESPAKVKTIKKFLGANYEVDASNGHVRDLPKSQMGIDVENDFDPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLMKALKLDELKDKQVYRISFNEITKNAVKASLKTPRVIDMDLVDAQQARRVLDRMVGYMISPLLWAKVKRGLSAGRVQSVALRLICDREEEIGAFIPEEYWNLEAVLKQEGSKKPLIAKFYGDKDGKIPIRNKEELEKILAGLEKQTYQVEEIKNGERIKKAPIPFTTSTLQQEASKVLNFSTQKTMRLAQQLYEGVEVAGRGTVGLITYLRTDSTRIAEEADAAAREYIGKQYGGQYVANGEQQKKSNAKIQDAHEAIRPTDISLTPVMVKESLQRDLFRLYQLIWKRFTASRMQPAVYETTSVRVGAGKYLFTLSASRLSFDGFMSVYVQEDDKEEANVLLGNLEKGSFLKLDKLESGQHFTQPPAHFTEASLVKAMEEQGIGRPSTYAPTITTIIARRYVAKENKNLYVTELGEVVNRMMKKSFPSIVDITFTANLEYLLDKVGDGSVQWKTVVKNFYPDLKEAVDKALVELETVTIADEVTDEICEVCGRNMVIKYGPHGKFLACPGFPECKNTKPYLEKIGVPCPKCGKEVVIKKTKKGRIYYGCEANPECDFMSWQKPSTKTCPKCGAYMVEKGSKLLCSNEQCGYSTDK
(410) DNA topoisomerase 3 [Clostridium saccharolyticum WM1]
2
MKSLIIAEKPSVARDIARVLHCTKNHDGVIEGEAYVVTWGLGHLVTLADPEDYDPKYKEWKMEDLPMMPDQFRLEVIKQTGKQYRVVKAQIHRSDVGEIIIATDAGREGELVARLILEKAGNKKPIKRLWISSVTDKAIKEGFAKIKNGHEYDNLYDAAMCRAEADWLVGINATRALTCKYNASLSCGRVQTPTLAIIARREEEIKNFVPKPYYGISAKCADPALSFTWRDEKSKSFRSFDRDRVEALFNHRKAIGEGVITEVKSVPKKTEPPQLYDLTELQREANRRFNYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDIVPSIKERLEACGVGPYRKLAGRLANQKIKTAPSFVNDKKVTDHHAIIPTEQFVQLDHMTIEERKIYDLVVRRFLAVLYPPFEYEQTEITLDLGGETLAARGKTVKAQGWKEVYENQDEEEEEQELKEQNLPVMKKGDMINGLTVTMTEGKTKPPAPFQESTLLSAMENPVSYMETKDKDMAKTLGETGGLGTVATRADIIEKLFSGFLLEKRGKDIFLTSKARQLLTLVPEDLKKPELTAEWEMKLSEIAGGKLKRAAFMKDIRQYSGELIRQIKTGEGSFHHDNLTSHKCPVCGKRMLAVKGKNNEMLVCQDRECGHREVVSRTSNARCPVCHKKLELKGKGDSQIFVCKCGYKEKLSSFKERRAKEGAGVSKRDVAKYMSEQKKEGNQPMNSAFADAFAKLNLGDNGK
(1620) DNA topoisomerase [Clostridium saccharolyticum WM1]
7
MSKSLYIAEKPSVAQEFANALKANGRRRDGYMESDQVIITWCVGHLVTMSYPESYDPKYKRWSLSTLPFLPREFKYEVIPGVEKQFKIVSSLLNRPDVDTIYVCTDSGREGEYIYRLVAQMAGVKDKKQKRVWIDSQTEDEILRGIREAKDESDYDNLSASAYLRAKEDYLMGINFSRLLTLRYGQHISNYLKSGKNTVISVGRVMTCVMGMVVRREREIREFVKTPFYRVIGTFSKEDPSNPGLSGLDFDGEWRSAPGSRYYESPFLYKENGFKERQYAEELINALSLMDPMEGTVVSIEKKKETKNPPLLYNLAELQNDCSRMFKISPDETLKLVQELYEKKLVTYPRTDARVLSTAVAKEIYKNIGGLKSFTPLSEAAAEVMEKGSYRTIEKTRYVNDKQITDHYAIIPTGQGLASIKGLSSLGIRVYEVIARRFLSIFYPPAVYQKYALELAAESVYPGSEPTLQHQMTNKEHFYANFRVMLDAGYLKVAEVSWGKKKQEEGNGGTPSEETVQEENNPESSQNQMNNPLFVAMLGSLKKGMKLSLKKLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLFHIKYLSLNSKTQVIVPTLLGEMIFDVVNASIRQLLNPELTASWEKGLNYVAEGTITPGEYMEKLENFVAGRTAGVLRLNNHYDLHGVFDAAAANYKKPK
(287) DNA topoisomerase 1 [Thermoanaerobacter sp. X514]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNSGKFEAKFYGTREDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYTNPEANYASKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFLASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVQEFYEDFYNTLKIAEEQMEEIDVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPNCDFILWDKPVDEKCPVCGSLLVEKNTKNGHILKCSNPECDYQKEVK
(1276) DNA topoisomerase 1 [Clostridium botulinum A str. ATCC 19397]
1
MGQKMGQNLVIVESPAKAKTIKKYLGKNYVVEASMGHVRDLPKSQLGVDIENNYDPKYITIRGKGELLDKLRKEAKKSSKVYLATDPDREGEAISWHLAHVLKIDESEECRIEFNEITKTSIKKAIKSPRRINENVVDAQQARRVLDRLVGYKISPILWSKIKWGLSAGRVQSVALRMICDREREIEEFIPKEYWTIECEVYKEKNKKPFIIKLTTKSGKKIEINNEEEAIEAIQDLKKGEFIVKKIKKTKKNKNPLAPFTTSTLQQDSYKKLNFSTKKTMSIAQQLYEGIDIKGFGAVGLITYMRTDSIRISEEAQKSTLEHIKSNFGEEYIPKTPRVFKGKKNIQDAHEAIRPTNIEITPTLAKESLTPQQYKLYELIWKRFVASQMASCILDSTSISIENGKYGLRASGSLIAFDGFMKVYEYSTEEEKDSIKIPELEDNEILGEKSINKSQHFTQPPARYSEASLVKTLEENGIGRPSTYAPIISTILDRKYVEREKKTLKPTELGDIVNNILSEYFKQIVDLEFTADMENKLDYIEEGKKSWREVVNDFFQPLIESIEIAEKEIAKITIEDKVTDVVCEKCGRNMVIKHGRYGDFLACPGYPDCKNTKPIVEEIDVKCPKCRDGKVLIKKSRKGRKFYGCSNYPDCDFVSWSEPVKEKCEECGSYMVKKQSKAKGEYYECANSECKHRKYLNNKE
(236) DNA topoisomerase [Clostridium botulinum A str. ATCC 19397]
3
MSKLLLAEKPSVARNIGEALGCKTRKNGYLEGNGYIVTWAFGHLLTLYDCKDYDHKLALWSFQNFPYIPTEFKYKVKNDGKNRNVVDAGAKKQLEIIKELINRGDVEEIISATDYDREGELIALLIFNYLKANKPIYRILINEWTPTEIKKGLKDLKKNEEMISLQDAGVSRQLADWVIGINFTSIATMKYTRGKGNLLNIGRVLMPTLKIIYDREIEIKNFKVEEFYELEATFKNKKGEYKGKFFYEKKEKFPNKKIMEKLKAEIKDKSGLVTEKTIEIKKENPPSLFNLSNLQGYITSKYKGFTADKVLKVAQSLYEKKHITYPRTESTALEESIKDKAKKVLEVLKNDLPFKDEIIFNTSKKVFNNAKVESHSAIMPTYIIPKNLTPDERLVYDAIKNRFISQFMKEAQYENTEIVTTVPGENYERLFKTKGKILKCKGWLKLYKEKKKDELLPPIEKDDEVEIKSLKIISKKTKPPAHHTEKTLLKAMETCGKNTKQSEDNEEESNILYGYSIGTAATRAETINKLKYAGYITPKGKSLLITDKGTKLIETFPIRELLDTDYTGKLEKKLYDMEKGKFKKEDFLKEIFNFTVNGVNKIKNIRSNVICDTRVKKDK
(195) DNA topoisomerase 3 [Clostridium botulinum A str. ATCC 19397]
2
MGKVLVLAEKPSVGRDLAKVLKCNKKGNGYLEGNKYIVTWALGHLITLSDPESYDEKYKKWSMDTLPMLPKRMKTTVIKKTSKHFSEVRKVMIRKDVEELVIATDAGREGELVARWIIDKVGFKKPIKRLWISSQTDKAILDGFRNLKPGKNYENLYHSAVCRSEADWIVGLNVTRALTCRYNAQLSAGRVQTPTLAMIVQREEEIKNFKPRDYYSIEGKTKGFTMHWESAKGRFNTFDEDLAKKVVSKVTGKEGKIIEVTESDKKKYAPALYDLTELQRDANRIFGYSAKQTLSIMQRLYENHKILTYPRTDSRYISKDVVGTLKDRLKAISISNYSKFTNEILKGNIKAHKGFVDDSKVSDHHAIIPTEEKPKLGNLSGEERNIYDLVIKRFLSVMLPPFEYIQTTIKSEVIGEKFVARGKVIKSKGWKAVYDREEFDDKNNNSDSDDIKDQTLPKVNKGDGIKFSNFKINKGQTKPPARFNEGTLLSAMENPQRYINLDKESSKTLGETGGLGTVATRADIIEKLYNTFYIEKRGKEIVPTSKGKQVIDLVPKDLKSPLLTAKWERELDSISKGNLRGQIFINKMRDYSTKLVEDVKNSKDKYVHDNLTGKKCPQCGKYMLEVKGKNGVINVCQDRECGYRENVSRFTNVRCPECHVKLELRGEGQGQIYVCTRCSFREKLSSFNKKYRNNQEKLNKRDVTKYMKKMQKENDEPINSALAEALSKLKL
(1331) DNA topoisomerase 1 [Acetohalobium arabaticum DSM 5501]
1
MAENLVIVESPAKAKTINKFLGKGFNVEASMGHVIDLPKSQLGINIEENFEPKYITIRGKGDVLKKLRKAVKKSDNVFLATDPDREGEAISWHLSRALKLDDESECRIEFNEITENAIQQAIEAPRSIDKDRVDAQQARRLLDRLVGYKLSPLLWKKVRRGLSAGRVQSVAVKIICQREEEIEEFEPDEYWSLEADLQTDSKQQFEAKLHRIDGDKFKLNNKEETDKVIVEAEKNNFVIEKIKERKRRNNPAPPLTTSSLQQRAASSLNFTAKKTMFIAQQLYEGLDLGSEGTVGLITYIRTDSTRISKEAQQDTRKFIEDNFGPRYRPKDTKKYKVKSGAQDAHEAIRPTSVFRTPKKVKSYLNNDQYRLYKLIWEKFVASQMTPAIYKTLSVDIKAGKYLFRSTGSRTLFKGYLAVDTFKNRKQDKDLPEDLEEGTEVELLEFKPEQHFTKPPARYTEAKLVKTLEKKGIGRPSTYAPTVAKIQDRGYVNKEGKRFVPTELGKTVNHLLNKHFPDVTDIKFTANLEQQLDDVEVGKEDWRELLKEFYFPFEERLNSAYENMEEVELEKEVTDEVCEKCGKNMIVKHGKYGKFLACPGFPDCKNTKPYLIKMGVDCIECEDGEVVQRKSKKGRTFYGCSNYPDCEFMIWYKPVQEYCPECGTFLMEKTTKKRGTEYLCADEDCDFKTTPEELESEE
(693) DNA topoisomerase [Moorella thermoacetica ATCC 39073]
7
MVNACDAGREGELIFRRIYAWCKGQKPVKRLWLSEATPAAIKEAFRHLRVGEELDNLAAAAEARAQADWLVGINTTRAFTCRHNRLLSVGRVQTPTLALVVAREREIRAFKPEPYFEVWATFRKSTGETYRGKWFREKQDRLQDKKKAGDLAKQISACGIVEKIEQKEVREQPPQLFNLNDLQKEANKKYGLTAQKTLDAAQALYEKHKLLTYPRTDSRHLTTALVRDTLAGRLEALTGIPAYAALVPENLPQLGKRYVDDSKVSDHHALIPTAVNPDLSKLSPVEQKVYDLVARRFLAIFYPDARYAVTRVVTTAGGESFLSQGRVELERGWKAVYGRQEEDGAESKDEESQTLPQLVEGEEVAVQGVEVKAKQTRPPQRYTEATLLAAMENAGRLVEDKEMADTLKTAGGIGTPATRAAIIERLIQVGYLRREKKNLLPTAKGETLIGLVPEEVKSVELTARWEEGLKEIEEGQRDCKEWLEGIKNFTTEVVRMAREQEAAPGADPDREVLGQCPICGREVMEYPKSYSCSGYKEGCRFAIWKEIAGKKVTASQAKELLQKGKTGVIKGFKSKTGKKFDAALTLGEGGKVNFEFAEGNRETLGKCPLCGKDVTESQKGYGCSGWKEGCKFVIWKEIAGKKITAGQAKELLQKGRTGVIKGFKSRAGKEFEAILVLKEDGKLEFEFEG
(1288) DNA topoisomerase 1 [Moorella thermoacetica ATCC 39073]
1
MLAKTLVIVESPAKAKTIGKFLGKNYTIKPSMGHVRDLPKSQFGVDVENNFEPRYITIRGKGEIVKELRAAAQKAQRVLLAPDPDREGEAIAWHLQHLLGLPDEAIRIEFNEITRNAIQEAVKKPRKIDQDRVDAQQARRILDRVVGYRLSPLLWRKVRKGLSAGRVQSVAVRLIVDREQEIEAFQPEEYWSLTAWLLPENEGEAFPARLVKYAGEDLNVKNEGEMESILHSLEGTTYVVAEVKQRERRKNPAAPFTTSTLQQEAYRKLNFTSRRTMQVAQQLYEGIDLGGGQGPVGLITYIRTDSTRVASVAQLEARDFLMERFGSEYVPEGLRQYKGRKDIQDAHEAIRPTSVWREPASLKNILTRDQFRLYNLIWERFVASQMQAAVMDTVTVDITAGPCLFRATGSVVKFPGFLKVYQEGRDGEDKDQEQRLPPLATGQTLKLQSLEPKQHFTQPPPRYTEATLVKTMEELGIGRPSTYAPTIETILQRGYVTREQKQFVPTELGRVVVALLKEHFPKIIDVEFTAHMEEQLDAIEAGKISWRQVLAEFYGPFEEVLEKAEAEIGTVEVPEEVSEEKCELCGRNLVVKMGRYGKFLACPGFPECRFTKPLLETIGVNCPECGGQIVARRTKRGRKFYGCQNYPRCTYVSWDKPTNQTCPRCGKRLVEKASRQGSRLVCPQKECGYVEEVRQAK
(748) DNA topoisomerase 3 [Clostridium cellulolyticum H10]
2
MGFTLILAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLIGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFTVQWQDSRNNQTRTFNKEEADGIVAKITGQMGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKPSVTKRFVDNSKVTDHHAIIPTEQFVDLFSLNSEERNIYDLIVKRFIAVLSKPFEYEQTTVKLDIAGESFYAKGKIVKSSGWKTVYDGFGKLDEDDEDDNDQSLPDIQKGHKAKVVGPKSINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERKGKEIYPTSKGTQLISLVPTDLKSPELTAKWEQQLTLISKGKVNSNVFVNDMKKYARKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHICPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGQQVDKREVAKFMRQQEKDENINSALADALAKWKNN
(1178) DNA topoisomerase 1 [Clostridium cellulolyticum H10]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAIKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVRKGLSAGRVQSVATKMICDREDEIEKFESQEYWSIIAKLVKPKASPNFGAKFYGIGKEKLELTNEEQVNSILEEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGYTTKRTMMVAQQLYEGIEIKGRGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPEKPREYKNKSASQDAHEAIRPTYIDLPHEQIKEYLSPEQYKLYRLIWDRFISSQMSSAIYDTVSADITAGKYLFKANGSKVKFPGFMVLYTEGNDNEGKDEAEQDEKENKLPQLNEGDILELKENTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAEMESELDSVEDGDKEWKAVMRDFYSSFAGVLKKAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNAKPIVEEAGVECPICKGKVLIKKTKKGRKYIGCEKNPECPFMSWDMPSPNKEVCSVCGSFMLQKFSGKKKVLKCSNDKCTSNIEASKDNTK
(261) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-mouse-Japan]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVSVEDDYEPNYINVRGKADLIKSLKKASKKSEKVFLATDPDREGEAISWHLAYILGIDVDDKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINSFEVKQYFTIEGSGKKNSKKYVFKLHSKHKEKLDELTENKVLEILDELSEGKYIVDEIKEGSKNKYPSPPFTTSTLQQEAYKKLNFQTKRTMSVAQSLYEGVEVKGYGVVGLITYMRTDSVRLSADSLNQANEFVAKVYGDKYKLDIPRQYGKNNKNIQDAHEAIRPTNVEITPDIAKQTLKDDQYKLYSLIWRRFLASQMRNAVYNTMAISIKNGDYLFKLNGSQLQFDGFLKVYEVDKDDKDLILPAFEEGEELKNVKVESIEHFTQPPPRYTEASFVKLLEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIEFTADMEKKLDGIEEGKASWKSIVHEFYKPLKEKIDIAENTVKKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSIIQKLNIPCPKCGGEINVRKSKKGKVFYGCSKYPECDFISWNEPSNVKCPKCGGITVKKIKRKQEFYECIDQDCKDK
(1023) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-rat-Yit]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVNIEDDYEPNYINVRGKADLIKSLKKYSKKSEKVFLATDPDREGEAISWHLAYILGIDLSEKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINNFEVKQYFTIEGTGRKNSKKYVFKLHSKNKEKLDELTKDRVSEILDDLSKGKYVVDEVKEGIKNKYPLPPFTTSTLQQDAYKKLNFQTKKTMSVAQSLYEGVDIKGYGVVGLITYMRTDSVRLSSDSLNQANEFVKKVYGDKYKLDKPRQYGKNNKNIQDAHEAIRPTNVEITPEIAKQTLKDDQYKLYSLIWKRFLASQMANAVYNTMSISIKNNGYLFKLSGSQLKFDGFLKVYEIDKDDKDLILPIFEEGEELNNIKIESVEHFTQPPSRYTEASFVKLMEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIDFTADMEKKLDGIEEGKVDWKNIVHEFYKPLKEKIDIAENTVEKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSITQKLNVSCPKCGGEINVRKSKKGKVFYGCNNYPECDFVSWNEPSDVKCSRCGGITVKKIKRKQEVYECIDENCKE
(657) DNA topoisomerase 1 [Bacillus atrophaeus 1942]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINEFKPEEYWTIDGSFLKGQETFEASFFGKGGKKLPLKSEADVKEILSQLKGNKYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAVEEAAAFIDQTYGKEFLGGKRKPAKKNENAQDAHEAIRPTSILRKPNELKTVLGRDQLRLYKLIWERFVASQMASAVLDTMSVDLENNGLTFRATGSKVKFSGFMKVYVEGKDDQLEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVGLDNKRFVPTELGQIVLELIMEFFPEIINVEFTARMEQDLDNVEDGNTEWVQIIDRFYTDFEKRVKKAEAEMKEVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPKCEEGNIVERKSKKKRVFYGCDRYPQCDFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVECDYKEEPQK
(1155) DNA topoisomerase 3 [Bacillus atrophaeus 1942]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDRYIVTWALGHLVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKAQLTRKDVSGIVIATDAGREGELVARWIIEKAHVNKPIKRLWISSVTDKAIKDGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYFGIRAAVEGMTLTWQDKKTKQSRTFDQAVTSRLLDKLEGKSATIADLKKTAKKSFAPGLYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFISNDIVPTLKDRLEGMEVKPYALYVTKILKRGVKAHKGFVNDAKVSDHHAIIPTEEPLIPSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIADIGGETFTAKGKTVQSQGWKAVYDAYDEEDDQDEDRDQTLPALQKGDSLPVRALKETSGQTKPPARFNEGTLLSAMENPSAFMRGDEKNLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKDKDIFITSKGKQLLQLVPEDLKSPALTGEWEQKLSAIAAGKLKSSVFIKEMKAYANETVKDIKNSSQTFRHDNVTGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKKLELRGQGEGQIFACVCGHREKLSVFEKRKSKEKTGRASKRDVSSYLKQQNKDEPINNALAEQLKKLGLDK
(311) DNA topoisomerase 3 [Bacillus clausii KSM-K16]
2
MKKKAVLAEKPSVARDIARVLGCNQKGNGYLEGNGYIITWALGHLVTHADPEHYGKQYKTWKLEELPMLPKRLELVVIKQTAKQFHAVKHVLNRQDVGEVVIATDAGREGELVARWILEKAHVKKPVKRLWISSVTDKAIKDGFKQLKDGKRYETLYAAAAARAEADWYVGINGTRALTTKHNAQLSCGRVQTPTLAILADREEAIRKFVPKPYHTISVETKDGVTFRWADRRSKEERIFDDKRAKTLQEKLQQSAIVIDSVNAKTKRTPPPPLYDLTELQREANKRFGYSAKETLAALQRLYEQHKAVTYPRTDSRYLSSDLVETLKERLHAVDVQPFRKMVANAKKQGLANAKRQMVNDAKVSDHHALIPTEQPQSASAMSDKEAKLYHLIVRRFLANFFPPSESELTSVEATANGELLRAKGERLVSAGWRGQETGEEDEALARLLPAMSKGDKKAVKWVGMTQGKTSPPPRFNEGTLLAAMEKPAQHMEAKDETIKKTLAQAGGIGTVATRADIIEKLFSSFYIEKKGKDLYITSKGKQLLELVPAELKSPALTAEWEQRLEKIVQGKEQKQMFIAEMKEYAKAVVAQVKADTATFRHDNKTGEKCPECGKFLLEVNGKKGKMRVCQDRECGYRKNIAMTTNARCPKCKKKLELRGEGEGQVFACVCGHREKKAQFEQRRKQNKHKNVSKREVQSYMKKQNKQDQFANSALADQLAKLGLKGDDS
(1709) DNA topoisomerase 1 [Bacillus clausii KSM-K16]
1
MSDYLVIVESPAKAKTIGKYLGKKYVVKASMGHVRDLPKSQMGVSVEDNYEPRYITIRGKGPVLKELKTAAKKAKRVYLAADPDREGEAIAWHLAHSLNIDENSDCRVVFNEITKTAIKDAFKHPRPINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKLITDREKEIQQFVPEEYWSITGTFLLGDEPFEAKFYGRNGKKESLTSEENVNEVLKQIKGKQFAVADVVKKERRRNPVSPFTTSSLQQEAARKLNFRAKKTMLIAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKQETYEYIRSTYGEEYARKGERKQKQDKNAQDAHEAIRPTSVKYEPKQLKEYLSRDQLRLYRLIWERLVASEMAPAIMDTMTVDLENNGVKFRANGSKVKFPGFMKVYIEGNDDNKKEEDRLLPALAKGQQVEKTEVTPNQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVALDEKRFVPTELGEIVLDLIVEFFPEILDVEFTAKMEEDLDSIEDGRDNWISIIDQFYQSFEKRLKVAEEEMEEVEIKDEPAGEDCEKCGHEMVYKMGRYGKFMACSNFPECRNTKAIVKEIGVTCPTCKQGNIVERKSKKRRIFYGCDRYPDCEFVSWDKPISRPCPKCQGLLVEKKSKKGVFVACTSCDYEEEKQ
(1128) DNA topoisomerase [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
3
MTTVILAEKPSQARAYAVAFTQSQKGEGQIKVADPILPADTVITYGFGHLVEMALPEAYDASYKRWSLKKLPIFPDQYKYLVSRDKKKQFNIVANLLKRADTIVIATDSDREGENIAWSIMRQAGIDLKQKHLFRLWINSLEKAAIREGFQNLRPGWDYYYRYKEAQTRQISDWLVGMNGSPLFTLLLRKQGIKGTYSIGRVQTPTLYMVYKRDQEIANFKPEKYWLLMADFWQGRKKFTGRLLPETKFKSPAELEQFLLAKGGSLGKQTGRVAKVDKEQKSQASPRLFSLSSLQTEANRRYHASASQVLQAVQNLYENKFLSYPRTDCNYITDNEYAYLAQNLDRYQGLLPNSAEVKEQMKPLKAEKRYVDSGKVQEHHAIIMTKTVPSQAQMGKMSKLEGQVYGLVLRRTLEMFLKAYVYEKTTALINVGQLTFKASGNVSVNLGWKILEGPVKDAQLPSLEVGQELTAKLKEQEEETKPPAKFTEGSLITAMKTAGKTLDDEDAQATLKDVEGIGTEATRASTIEILKKRGYMQSRQNKLSVTPEGTILCKVAEAEPLLVSAQMTAQWEKALKQVGAKERSQDNFLGQIKKFISKMITEVPGKIQVDQGLQEEAQTRQAKTAAIGPCPVCKQGEITDKGKFYGCSNYRGGCHFTLPKKFAGKNMGKRIVKTLISKGKTDKLDGFISKKSGQRYSAKLQLEGDKLSLVFD
(1067) DNA topoisomerase 1 [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
1
MPATAKEDKSKSSKKTTAAAKKSSPKRKKSKVKKDLVIVESPAKAHTIEKYLGRKYRVIASKGHIRDLPKSQMGVDIDHDYQPKYISIRGKGDTIKELKAEAKKANKVYLASDPDREGEAIAWHVAHVLGLDEKEANRVTFNEVTKDAVKDAFNHARTIDMDTVNAQQARRVLDRLVGYSLSPILWSKVKKGLSAGRVQSVALKLVIDREKEIKAFKPVEYWTIDAEFAKGKDKFQASFYGEEGKKTELPNNEAVQKLLAKFDKKQPFTVSKVVKREVRRQPAAPFTTSTMQQEANRRLNFRTSKTMNIAQHLYEGISLGKEGTVGLITYMRTDSKRISPVARQEAAQFIVEEYGSDFAVKKERHFKNQGDAQDAHEAVRPTSVYRTPKSLEKVLTKDELRLYTLIWSRFVASEMTPAVFDTVRYDLTQNGVTFRASGSVMKFAGYTKVYDNRSEKNVALPALEEGDEVKLTKSDNKQHFTQPPARYTEASLVRALEENGVGRPSTYAPTIQNIQSRNYVKLEGRAIVPTELGEIVDGLVEQFFPDITSVDYTAKLEDELDEVEEGKKDWVSVVDQYYKPFSKELEKADSEIQKIQIKDQPAGFDCEVCGAPMLVKMGRYGKFYGCSRFPDCRHTQTIVKKVGVTCPKCGEGEVLEKKSKRGRKFYGCSRYPDCDFVSWDKPISRVCPHDGHFLVEKKRKDGMVVLCPNGDYKEEPREEQGEAAE
(281) DNA topoisomerase [Streptococcus pasteurianus ATCC 43144]
3
MNAEVIVAPAVGHLVERINPYTNFENWEMANLPALPDGFAYEPKKDTAKRFKAIKQSVKEVDAIIIGTDPDREGEAIAYRILELIPGALRKIKYRLWANSLTKKGLEQAFSKLKNPKDSINYFHEADARGDADWLVGFNLSPFVTIKMKEEGYLDKKDHSMSVGRVQTPIVSLIVRNDEAIENFKPSPYWQLKLIDPEAKVTFGNDIKYQSKAEAELMLQQLANIAIVKTVTSEEKVQEAPKLYNLTNFQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFAYLVEHIDDYQMAIHKQLETPNRSPRKNYVNDKKVLEHYAIIPTENIPDLNELSDDEKLIYQKVVFRTLLMFAPDYRYQSTSVILDNHGLEFKASGTVTKDNGWRNYLAAKKEDKELPHYQEGKNLVVDCKLLEEMTKPPTRITEQILLKKLLPKYNLGTSATRDGMIDLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVNKIKWAITKQIEKGKQI
(1860) DNA topoisomerase 1 [Streptococcus salivarius 57.I]
1
MATATTTKTKTKTTKKTTAKKATKKRATPKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINELKKEAKKAKQVFLASDPDREGEAISWHLSHILGLEPDDKNRVVFNEITKDAVKNAFVEPRAIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGAFKKGAKKFQASFYGLDGKKLKLNNNDDVQAVLSRITSDDFNVDKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGINLGSGAQGLITYMRTDSTRISPVAQNQAAEFITERFGSKYSKHGSKVKNSSGAQDAHEAIRPSNVFQTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVTLSQNGVIFTANGSQIKFDGYMAVYNDSDKNKMLPDMAEGDTVKKVVTTPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVKLVAKRFEPTELGEIVNSLIVEFFPDIVDVKFTAEMEGKLDKVEIGKEQWQKVIDEFFKPFQKELEKAEEGIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVTCPTCGKGQVIERKTKRNRVFYGCDRYPDCEFTSWDIPVGRNCPKSGDYLVEKKVRGGGKQVICSNEECDYKESIVK
(1537) DNA topoisomerase 1 [Streptococcus pneumoniae TIGR4]
1
MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNNEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKMALCQL
(915) DNA topoisomerase 1 [Lactococcus garvieae ATCC 49156]
1
MAKASEKQTTKKKKTSSKKTASKKKTKIVKGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIDNDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAIAWHLAHILGLPLEDKNRVVFNEITKDAVKNAFKEPRSIDVDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPQEYWSIDGEFKKGAKKFKAAFWGVDGKKRALNNNDDVMEVMSRLSGPDFDVDKVEKKERRRNSPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGLTLGAQGHQGLITYMRTDSTRISPVAQGVAADFITDRFGAKYSKHSSKVSNKAGAQDAHEAIRPTNVLNTPEAIAKYLDKDQLKLYTLIWNRFVASQMTAAIFDTMKVNLSQNGVIFIANGSQVKFDGYLAIYNDSEKNNMLPDIAAGDVVKKANLKPEQHFTQPPARYSEATLIKVLEENGVGRPSTYAPTLETIQKRYYARLVAKRFEPTELGEIVNKLVVEFFPNIVNTEFTAEMEKDLDKVEEGQRRWVDVVDQFYKPFAVELEKAEVEMEKIVIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAIVKEIGVTCPSCHKGQIIERKTKKNRLFYGCDRYPECEFTSWDKPVGRSCPKCEHYLVEKKVRGGGKQVVCSNETCDYKEEKQK
(916) DNA topoisomerase 1 [Lactococcus garvieae ATCC 49156]
1
MAKASEKQTTKKKKTSSKKTASKKKTKIVKGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIDNDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAIAWHLAHILGLPLEDKNRVVFNEITKDAVKNAFKEPRSIDVDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPQEYWSIDGEFKKGAKKFKAAFWGVDGKKRALNNNDDVMEVMSRLSGPDFDVDKVEKKERRRNSPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGLTLGAQGHQGLITYMRTDSTRISPVAQGVAADFITDRFGAKYSKHSSKVSNKAGAQDAHEAIRPTNVLNTPEAIAKYLDKDQLKLYTLIWNRFVASQMTAAIFDTMKVNLSQNGVIFIANGSQVKFDGYLAIYNDSEKNNMLPDIAAGDVVKKANLKPEQHFTQPPARYSEATLIKVLEENGVGRPSTYAPTLETIQKRYYARLVAKRFEPTELGEIVNKLVVEFFPNIVNTEFTAEMEKDLDKVEEGQRRWVDVVDQFYKPFAVELEKAEVEMEKIVIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAIVKEIGVTCPSCHKGQIIERKTKKNRLFYGCDRYPECEFTSWDKPVGRSCPKCEHYLVEKKVRGGGKQVVCSNETCDYKEEKQK
(917) DNA topoisomerase 1 [Lactococcus garvieae ATCC 49156]
1
MAKASEKQTTKKKKTSSKKTASKKKTKIVKGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIDNDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAIAWHLAHILGLPLEDKNRVVFNEITKDAVKNAFKEPRSIDVDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPQEYWSIDGEFKKGAKKFKAAFWGVDGKKRALNNNDDVMEVMSRLSGPDFDVDKVEKKERRRNSPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGLTLGAQGHQGLITYMRTDSTRISPVAQGVAADFITDRFGAKYSKHSSKVSNKAGAQDAHEAIRPTNVLNTPEAIAKYLDKDQLKLYTLIWNRFVASQMTAAIFDTMKVNLSQNGVIFIANGSQVKFDGYLAIYNDSEKNNMLPDIAAGDVVKKANLKPEQHFTQPPARYSEATLIKVLEENGVGRPSTYAPTLETIQKRYYARLVAKRFEPTELGEIVNKLVVEFFPNIVNTEFTAEMEKDLDKVEEGQRRWVDVVDQFYKPFAVELEKAEVEMEKIVIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAIVKEIGVTCPSCHKGQIIERKTKKNRLFYGCDRYPECEFTSWDKPVGRSCPKCEHYLVEKKVRGGGKQVVCSNETCDYKEEKQK
(347) DNA topoisomerase 1 [Lactobacillus buchneri NRRL B-30929]
1
MATSTKTKPKAKAKSKTKRKSPKKNLVIVESPAKAKTIEKYLGRSYKVVASKGHVRDLPKSKMGVDIDHDYEPHYISIRGKGDTIKELRSAAKKAKKVYLAADPDREGESIAWHLQHILDLDPNEDNRVVFNEITKDAVKESFKHPRNIDMNLVDAQQARRILDRLVGYSISPLLWQKVKKGLSAGRVQSIALWLIIQREKAIKDFTPEEYWSIDSEFKKGRSKFKAAFYGLNGKKKELPNNEAVQKVLQQLDPKGDFDITKVTRRERKRQPQPPFTTSTMQQEANRKLNFRTRKTMMAAQQLYEGINIGKEGSQGLITYMRTDSTRISVIAKHEASQFLHEKYGAEYAATKPIKGKLPEGAQDAHEAIRPTSVFRTPASLKQYLTRDQFRLYQMVWSRFVASQMTPAIMDTMAVTIEQNNVTFKANGSKMKFDGFLKVYGDSKEKDNLLPDLESSDVVKLVKNNPDQHFTQPPARYSEATLIKALEEKGVGRPSTYSPTIDTIQRRYYVKEVGRRFEPTELGEIVNKIIVEYFPDVVNIDFTANLEGKLDQVEEGKENWIKLVDTFYKPFSDEVDAATKNMEKVQIKDEPAGINCEICGAPMVIKMGRYGKFYACSRFPDCRNTKAIVKEIGVICPKCHKGQVIERKSRKNRIFYGCSRYPDCDFVSWDKPIGRDCPKDGHFLVEKRVKGGTQVVCPNGDYEEPAQK
(273) DNA topoisomerase 1 [Lactobacillus helveticus DPC 4571]
1
MPTKAKSKSKTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDNYKPKYISIRGKGDTIKELKSEAKKAKEVYLASDPDREGEAIAWHIAHALNLDENAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWTIDAEFAKDKEKFKSAFYGVDGKKKELPNIDAVKDVLAKIDKKKNFTVEKVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRTSPVAQQEASKFLHENYGAEFAAKNQRHFKNQEDAQDAHEAIRPTSVYRTPESLKDVLTKEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVIFRTTGSKMKFAGFTKVYDNQQEKNVELPDLQEGDQVKMTKSDNKQHFTLPPARYTEASLVHALEKNGVGRPSTYVPTIDTIQRRYYVKLDGRSIVPTELGEIVDTLVEEFFPDIANVDYTAHLENELDEVEDGKKQWVNVVDEYYQPFKKELNKADSEIQKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKIGVVCPKCGKGEVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKHSKKGPVTLCPNGDYREEPQENEDK
(1107) Uncharacterized protein [Lactobacillus reuteri SD2112]
1
MATKTTKSTAKKTTRRRSKIKKNLVIVESPSKAKTIGKFLGRSYKVVASLGHIRDLPKKPDGGRY
(1379) DNA topoisomerase 1 [Lactobacillus amylovorus GRL 1112]
1
MPTKAKSKPKTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFDDNYKPKYISIRGKGDTIKELKSEAKKAKEVYLASDPDREGEAIAWHVAHALNLDENAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKEFKPKEYWSIDADFKKGKDSFKSAFYGVDSKKKELPNIDAVKEVLAKIDKKKDFEVAKVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRISPVAQQEASKFLHEKYGAEYAAKSQRHFKNQEDAQDAHEAIRPTSVYRTPESLKSVLTTEQYRLYKLIWSRFVASEMKPAVYDTVRADIVQNGVMFRTTGSKMKFAGFTQVYDNQQEKNVDLPDLEEGDKVQMTKSDNKQHFTQPPARYTEASLVHALEENGVGRPSTYAPTIDTIQRRYYVKLEGRSIVPTELGEIVDTLIEQFFPDIANVDYTAHLEDELDEVEDGKKQWVNVVDEYYQPFKKELDKADSEIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKEIGVVCPKCGKGQVVEKKSRRNRKFYGCSRYPDCDFVSWDKPIGRNCPNDGHFLVEKRSKKGPVILCPNGDYREDPQEDEIDK
(214) DNA topoisomerase [Lactobacillus salivarius UCC118]
7
MKKLILAEKPSVARDIGRILNANEKKKNYLEGKNYIITWALGHLLGLKMPEDLNKKWEKWQLETLPMLPKFIGIKPLPKTRGQLKTIESLVKRKDINEIVIATDAGREGELVARWILQYVHANKKVTRLWISSQTDKAVKQGFKELKPAEKYDNLYESALARATADWLVGLNVTRALTVKYQDNLSAGRVQTPTLALVRRQEEKIEKFMPQKYYRIALRIGKQTAYMKQKNIYAIKERDEAEKKKRHLDNFKGQIKDINSKIKREPAPLLYDLTELQREANKRYGYSAKKTLSLVQSLYEIHKVVSYPRTDSRYLSNDIKATLMERLQAIRKYDSRAEEAIKNKAKVILKKVFNDSKVTDHHALIPTEQVPNYSKFSADEQKIYNLIVSRFLGIFAQPYTVEELRVVVTFDKDEFIFVGKKVLDYGWKNKDAAEEVVLNLKKDTAVSPNFTVEEKLTTPPAPLTEAGLLAQMEKFGLGTPATRAEIIEKLVKSELMERTGHALRVTPKGKQLLNLVNKELVSPKLTAKWEKQLEDIAHGKMKSQKFIGDIKNDTKRLVSEVKNSKEDYKDFSLTKKRCPECNSFLKVRKTRDGEIYVCSNPECNYRRRKDAKVSNHRCPQCHRKMLIVEGKNGKYFRCKYDGTTEKMTVGKKSKKMTKHEERRLLKKINQDDEPQESPLALALKAAMGKNE
(1686) DNA topoisomerase 1 [Lactobacillus salivarius UCC118]
1
MPTTQKPKKKTTKRTRKKNLVIVESPSKAKTIEKYLGSNYKVMASLGHIRDLPKSKMGIDVENGYEPHYISIRGKGDVIKELRKEAKKASHVYLAADPDREGEAIAWHLSYLLGLNPEDKNRVVFNEITKDAVKNAFKSPRSIDMNLVDAQQARRVLDRLVGYSISPLLWSKIKKGLSAGRVQSIALNLIIQREKEIRDFKPEEYWTIDAKFKKGRTKFEADFWGVDNKKKKLSNEKDVKEVIEKIDKDKPFNVINIEQKERKRMPPLPFTTSAMQQTANNNLKFRTQKTMMVAQQLYEGINIGRGGAVGLITYMRTDSTRISSVAKHEAAVFLHENYGEEYAASKPRQGKLSENAQDAHEAIRPSSVERTPEKMAKYLDKDQLKLYTLIWSRFVASQMTPAVFDTMRVDIEQNGVQYRANGSKMKFPGFIKVYKAATSKDNLLPELKVGDEVDMVQNQPNQHFTLPPARYSEATLIRTLEENGVGRPSTYAPTLSTIQKRYYVKLVSRKFEPTELGEIVNSMIEECFPDILNVDFTAHLEDQLDDVEEGKEEWVRIIDEFYQPFSKEVDNAQVKMDKIKIKDEPAGIDCEICGAPMVIKLGRYGKFYACSRFPDCRNTKAIVKEIGVVCPKCHKGQIIERKSKKNRVFYGCSLYPDCDFVSWDKPIGRDCPKCSHYLVEKKTKKGMQVKCSNCDYEEAIQNN
(880) DNA topoisomerase 1 [Helicobacter pylori F32]
1
MKHLIIVESPAKAKTIKNFLDKNYEVIASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKELVKQIIELSKKASTTYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPRKIDMSKVNAQQARRFLDRIVGFKLSSLIASKITKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDAYFESHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYTISGIIKKSKKSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARNKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSIVLEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQSVVVACEKGEFKASGRKLLFDGYYKILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVMEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYVKQTENANDGAKQELCEKCGGEMVQKFSKNGAFLACNNYPECKNTKSLKNTPNANEIIEGVKCPECGGDIALKKSKKGSFYGCNNYPKCRFLSNHKPINKRCEKCHYLMSERIYRKKKAHECIQCKERVFLEEDDG
(764) Topoisomerase I [Helicobacter pylori F32]
3
MKDSVIIIESPNKVAKVKEITGAKVFATIGHFMQLKSYDENNNFKPTFEYDSQKKKRIFEIIEACKNKKVYIATDPDREGYAIGYHFYEKIKKIASSIYRAEFFEITPSGINKGLQNALLFENTNKQMYQSALARRVADMLLGFTLSPYLGKALGQMKGSSAGRVQTPCLKLIVDRDREIEKFKALPENEKVSYQIQAKINDNANREVIIKHCDEKGEEIKFNDKEEALKLFESLKDNKACLLKDLKISVVETKPKKPFITSTLLERASSELGLGIAEVQSLAQSLFEAGLITYIRTDAESLSVEFLNEAESFYLPIYKEVYQKREYKAGKQSQAEAHEAIRITHPHKYEDLESIVYNAGITNQDALKLYRLIFERTIESQGKNAIYDKQDLLFKIKNEYFKCSAKSLKSTGFLAMFSKKELENDDESNDDKEDKEKEQNAQFNLKIDDMLSLNDLVLATIKRNAPSPYKEASFVKLLENKGIGRPSTYASYLSTLLKREYISISQDKKHTITPTHKGKRVIEVFENAYQFIIDLTYTKQMEEVLDEIVENKSSYLDFLQNLATKCPKIEKLERNDDEIKPSSEGQITYIENILRDLQLDLSEEFKNYKEDNRIAKAFLDRYIKEHEFFEKNNKKASSSNNNEIRPATPKQINFAEILAKKHNVKLPKDYKSNIKVCGDFINEYHKK
(1497) DNA topoisomerase 1 [Helicobacter hepaticus ATCC 51449]
1
MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDHMEIVEKIKVASKKAKVTYIATDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITHSLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQRGLSAGRVQSSALKIIVDREREIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAMLEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVETNFGSMGVITYMRTDSLNIAKEAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAIRPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDALFEIQNIIFTPHNQTHLIEFKASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSMESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGLEDKLDEIAQAKMNWESVLWEFYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRKSKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGEPMIKKFGRNGEFIACSGYPKCKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKCPQCGGISVEREYRKKQVRECLKCKHRIEI
(525) DNA topoisomerase 1 [Helicobacter canadensis MIT 98-5491]
1
MSLKDLIIVESPTKAKTIKNFVGSNYEVIASKGHIRDLPKHSFGIKIDNQEFIPEYKIDESHKNIVSELKKLAKDSKTIYIATDEDREGEAIGFHIATAIGKDPQKLPRIVFHEITKKAILDSLKNPRHIDMDKVNAQQARRLLDRIVGYRLSPLIASKIQRGLSAGRVQSSALKIIVDREKEILNFKPITYYSIDIAFKEQLESELLEFKGKKIQKLSLQDKAEALEMIQQLKQESFKVKEIENKKRKTATPPPFMTSTLQQSASSILGFSPSRTMQTAQKLYEGVMTHKGSMGVITYMRTDSLNIAKIAQDEAREFITKTYGKEYAPSKPKNYATKAKGAQEAHEAIRPTLVDFTPQIAAQYLKGDELKLYTLIYNRFLASQMSDAEFELQNIFIDSNSSLLKISGRKLIFDGFYRILGNEDKDKLLPHLKVGEVLKLEKCDLSEHQTEPPARFSEASLIKTLESLGIGRPSTYAPTISLLNSREYISIEKKQIKPQEIAFKVVELLEKHFLEIVDSKFTANLEEKLDEIAENKQDWQKLLWEFYEPFIQKVNEGKTSIQSQKIALPTGENCPLCGKELIKRSGRFGEFVGCSGYPKCKYIKKEVEENAQEESYGVCEKCGKPMVKKRSRSGEFLACSGYPECKNTKSLNNSAPSAKKAVEGVKCPKCSGEILERMSRRGKFYGCANYPKCDFISTYEPTNVHCPKCNSLMAKRTYRKKAVLECIACKERIEEIQTTIKE
(129) DNA topoisomerase 1 [Caldicellulosiruptor lactoaceticus 6A]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEVLKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVSCPKCSKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGGLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(810) Reverse gyrase [Caldicellulosiruptor lactoaceticus 6A]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEQCLSQEQISKNIFESLKKKGTLKDYQIYWNFQQNFDTFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEAFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFENLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILSELFNDLKNLIEN
(132) DNA topoisomerase 1 [Thermosediminibacter oceani DSM 16646]
1
MAKSLIIVESPAKAKTISRFLGKEYRVAASMGHVRDLPKSKLGIDIEKGFVPKYITIRGKGSIIENLRKEAAKAQKVLLATDPDREGEAISWHLAHLLDIPPETPCRVEFHEITKTAVSESLRHPRKINMNLVDAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSAAVRMICDREKEIAEFVPEEYWTIEAELADRPDGSSFKAKLHSRGNEKINLKNREQVEKIVADLQDQVFVVMEIKRGERRRNPAPPFTTSTMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGTVGLVTYIRTDSTRISEQAQKEAKEYIKANYGSEYVAESMSVKKAKKNIQDAHEGIRPTSVFRHPDSIKDSLTLDQYKLYKLIWERFLASQMAPAVYDTVSIDIKAGSYIFKASGSTLKFTGFMAVYIEGADEETEKDEGTLPILEQGQKLTLLKIMPEQHFTQPPPRFTEAMLVKALEEKGIGRPSTYAPIIDTIQKRGYVKKEKGRFKPTELGQLVTEILKEYFSDIVDLDFTAEMENQLDKIEAGEENWQKIIESFYRPFEEKLKIAEEKIEEVKIEDEVTEEKCELCGRNMVIKHGRYGKFMACSGFPECKNTKPLLEETGVKCPVCEGVIVVRKSKKGRKFYGCSNYPNCEFVTWDPPSETPCPRCGGLMVVKSTKSGKITACTNTECGYKDQVEG
(1657) DNA topoisomerase 1 [Pediococcus claussenii ATCC BAA-344]
1
MPTAKKNLVIVESPSKAKTIEKYLGRSYKVIASLGHIRDLPKSKMGVDIDNNYDPHYISIRGKGDTIKKLRTEAKKAKKVYLASDPDREGEAIAWHLSYLLGLDPKDKNRVVFNEITKDAVKNAFKTPRSIDTSLVDAQQARRILDRLVGYSISPLLWQKVKKGLSAGRVQSIALSLIIKREQEIRDFKPEEYWSIDSEFKKGRSKFNASFYGTGGKKKALKNEKAVQKILKLINPKDDFDVTSVKRKERKRFPSPAFTTSSLQQEANKTLNFRTRKTMMAAQQLYEGINIGKEGTVGLITYMRTDSTRISDIAKHEASVLIHEKYGAEYAAIKPRKGKMPEGAQDAHEAIRPSSVNRTPEDLKEYLSKDQYRLYNLIWSRFMASQMTPEVSDTMAVTIEQNDVQYRANGSKTKFEGFTKVYKTNKEKDNSLPAMEEGDKVKLVSNNPNQHFTQPPARYSEANLVKALEENGVGRPSTYAPTLDTIQKRYYVKLESRRFEPTELGEIVNDIIYEFFPDIVNIDFTAHLETELDEIEEGKEDWVKVVDGYYKPFSKEVDTAQEQIEKVQIKDELAGFDCEVCGSPMVVKMGKYGKFFACSRFPDCRNTQAIVKEIGVTCPKCGIGQIIERKSKRGRLFYGCSRYPDCDFVSWDKPVGRKCPVCHSFLVEKKIKGGKQVVCPNGDYEETPQK
(1042) DNA topoisomerase [Pediococcus claussenii ATCC BAA-344]
7
MKKKLIITEKPSVATDLARVLGVEQKNKTYYEGNNYIITWAYGHLLTLKLPEDINKDWQNWDLNDLPIIPKNIGIKPLPKTKQQLKAISRLAKRTDVESAIIATDSGREGEAVARYILEWIRFNKPVERLWISSQTTKAIREGFSNLRPAEQFDDLYASALARGKADWLVGLNVTRALTTKYKDNLSAGRVQTPTLSFIWKQEQEINSFRPHKFYKIYLVYQGQTADLLLKNSEQFETREQAEKVVQGLQKKSGLVEDLKVKQNMQDAPLPYDLTELQRTANSMYAFSAKKTLSIVQSLYEVHKIVSYPRTDSKYLSTDIKDTLKERLSALSGFDSQAKAYLRRGAKIVQRSVFNDQKVTDHYALIPTEESVQPAKLSSDELRIFRLIEKRFLGLFAEKFITETTNTTIGFGSAKFVFKQTRVVKPGWRFDLETETKKTKVQLKLKQQIEGQFIIKEKLTTPPKPLTEGTLLGKMEKFGLGTPATRAEIIEKLTQSELVKRTNGALITTPKGQQLLKLVNKSLASPDLTSKWEKSLESIAHGKVNYMDFVKDVEKETRRLVSEIKTSEIEYRDFGVTNKLCPECGYALKERNSRDGKILTCSHCGYRRRKDPKVSNHRCPQCHKKMVILEKNGQSYFRCLNDGTTEKMLDKKERKKKISKKEERKLLSKINNEDPEESPLAIAMKKAMEK
(1197) DNA topoisomerase [Carnobacterium sp. 17-4]
1
MEKVKKGLSAGRVQSVALKLICEREDEINRFEPEEYWSIGANFKKDKKKFKANFYGLKGKKQALSNAEDVQKIIKELDGDQFEVMSVTKKERLRNPALPFKTSSLQQEAARKLNFRTRKTMMVAQQLYEGISLGRGGAVGLITYMRTDSTRIALSAKNEAAEYIIKEFGPEYAASKPRIGKKAEGDQDAHEGIRPSSVLRTPKEVEKYLTKDQYKLYNLIWSRLVASQMTPAVFDTMKVDIAQKDVYFRANGSKVKFPGYQKVYIEGNDEGKEEKDNLLPEMEKGDKVKSIDIEPKQHFTQPPARFSESTLIRVLEDNGVGRPSTYAPTLETIQRRYYVKLQNKRFEVTELGGIVNGLINEFFPQIVDVHFTADMEKNLDEVEEGNKEWEKVIDQFYQPFAVEVEKAEENMEKVQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKPIVKEIGVACPVCGEGHVIERKSKKNRIFYGCDRYPTCEFVSWDKPVGRSCPKCEHYLVEKKAKGSKQVICSNCDYKEEVQK
(1700) DNA topoisomerase [Carnobacterium sp. 17-4]
7
MKTLIIAEKPSVGKEIARVLGATQKSKTHIEGKDVIVTWALGHLLGLKMPEDYKAEWATWDLNALPLIPEKMTTKPLTNTRGQLKAIKQLANRKDIGSAVIATDAGREGELVARWILEYVNFNKPVKRLWISSQTDKAIKDGFNQLQPSKKYDTLYDSAVARSEADWLIGLNVTRALTVKYQDNLSAGRVQTPTLAMVRKQEAKIQSFVPETFYTVQLTVDGKKAVLQEGAPRKFNDREKAEALVSSLKDKPITVVDIKEKQSVQQAPMPYDLTELQREANQRYQFSAKKTLSLMQTLYERHKVLSYPRTDSKYLTQDMVGTLKERVMAIQGFAPEEAKGILKRGAQVTQKGVFNTAKVTDHHGIIPTEERPRPEKMEADELKIYRMVVERFIGLFLPAYKVSKTTIVFSAADVLFSLQQETVLEKGWKKDVPKQSENVYKLNEQLMRTAYTIQKQLTEAPTRLSEGTLLQNMEKNGLGTPATRAEIIEKLISSELMERNQNKLSTTPKGQQLLTLVNPALVTPELTSKWEKSLEEISNGGLKKEDFLKNIKQETARLVTEIKTSTQTYKDHALTSKICPECGELLKERSGRDWKLLICSSSTCSYKRRKDPKVSNHRCAQCHRKMEIHEGKNGNYFKCKYCNITEKLEGKSSKKPSKHETKKLMQKINNQQEEVESPLALAMKAAMAKKE
(441) DNA topoisomerase [Carnobacterium sp. 17-4]
3
MDQSMGHTVILAEKPSQAQAYAESFGKFSKKDGYIVLNSSNDVITWGFGHLVELASPEEYKDEWKKWNMKELPIIPEIFKFKVGQGKAKQFNVVKKLLQEADQIIIATDSDREGENIARSIINQAKAGNKEIKRLWINSLESDEIQKGFSDLRDGREFYSSYIEAQTRQISDWLVGINLSRMYTLSLQKKGINEGVFSVGRVQTPTLYMIYTRQKQIENFIPEPFFELHATVKAENGLFKAKYSKKFSTKKELQELIQKHGLLASNPGMISSVETKRISQPSPFLFSLSDLQSLVNKKYKVSPSDTLKHVQSLYEAKLVSYPRSDCRYITDSEFRYLLERIEGYQGILNHTIKEPNTSKRKRYVDGSKVQEHYAIIPTKKVPTQKALEKLPSIQREIYFTILRRSMAMFETDYKYDETTVTVDIKTVPFISKGKVILDKGWQRLEYGASKKSNKETTSELPLVKKGELVEADLNTSEGFTSPPKTYTEGTLITAMKTCGKELENEEEKEILKATEGIGTEATRANVLETLKKQNYIEIQKNNVTVTQKGEILCQAVENTLLSSPEMTAKWETYLKKIKNEDGTQQAFLDSIQKFIAHTLDSSAQVIEKRDWSTHTNSINHLSQKTIGKCPVCGQMMIDKGKFYGCSGYSNGCTFTLPKRYVGKTLSEATLKKLLDTRETQLLKGFKKKTGQTFSAALILTEDNKLLFKPYEKTEKK
(839) DNA topoisomerase 1 [Enterococcus faecalis V583]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQEKWVEVVDRFYKPFEKELTNAEEKIEKIQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVTCPVCHEGQVIERKSKKNRIFYGCSRYPECDFTSWDKPVGRPCPKCGQYLVEKKVKGGKQVVCINGDYEENVQK
(1315) DNA topoisomerase [Enterococcus faecalis V583]
7
MVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILEYVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALTVKYQDNLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTISLSVESEKAKMTQKNPYALKERQEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAEQPLSTVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLGTPATRAEIIEKLIKSELMERTNSGLSVSAKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVCTNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMTKHEERRLMKKYSQPDEPEESALAQALKAAMNQE
(25) DNA topoisomerase III [Enterococcus faecalis V583]
7
MQLVIAEKPSVGMALSKVLGAKSRGDGYMEGGGWLVSWCIGHLVELAPADAYDPRYSKWNYADLPILPKPWQFQVLPDTKKQFEVLKTLIHRADVTALICATDAGREGELIFRLTYHLCGCTKPVKRLWISSMEEAAIQKGFDNLLDGKNYDNLYAAALCRAKADWLIGINGTRLFTTLYQGKSLNVGRVQTPTLALLAEREAAISGFQKEKFYTVELELEGFRAASERFASKTDAGRLRTGCVGKPATVQTVSQKEKTERPPKLYDLTTLQREANRLFDYTAQQTLDYLQALYEKRLATYPRTDSRYLTEDMAAGLPALCQSVAAALPFAADLSLPVNAAQVIDNSKVTDHHAILPTTEAAKTDLSALPSGEKNILFLVAARLLCAVGEPHTYAETAVTLECGGAVFSAKGKTETAAGWTAMEQAFHATLKKKPKQPEPSPPLPALTKGQKLTAGGASIKEGATSPPAHFTEDTLLSAMEHASAKEFAKLEDVEHKGLGTPATRAGVIEKLVRSGFVERKKKQLFPTEKGTELIKVMPDTLKSVKLTAEWEERLGAVERGELSPEDFMAGITAMLTELVKSYQGVTVASAALSASGRTVIGICPRCGKNVVEGKKSFFCEGWNAAPACDFALWKNDRFFTSKHKELTRKAAAALLKKGRVAMTGLFSEKKGVLYDAIVVMEDTGEKFVRFKLEFDNNTPKKKGN
(26) DNA topoisomerase III [Enterococcus faecalis V583]
7
MQLVIAEKPSVGMALSKVLGAKSRGDGYMEGGGWLVSWCIGHLVELAPADAYDPRYSKWNYADLPILPKPWQFQVLPDTKKQFEVLKTLIHRADVTALICATDAGREGELIFRLTYHLCGCTKPVKRLWISSMEEAAIQKGFDNLLDGKNYDNLYAAALCRAKADWLIGINGTRLFTTLYQGKSLNVGRVQTPTLALLAEREAAISGFQKEKFYTVELELEGFRAASERFASKTDAGRLRTGCVGKPATVQTVSQKEKTERPPKLYDLTTLQREANRLFDYTAQQTLDYLQALYEKRLATYPRTDSRYLTEDMAAGLPALCQSVAAALPFAADLSLPVNAAQVIDNSKVTDHHAILPTTEAAKTDLSALPSGEKNILFLVAARLLCAVGEPHTYAETAVTLECGGAVFSAKGKTETAAGWTAMEQAFHATLKKKPKQPEPSPPLPALTKGQKLTAGGASIKEGATSPPAHFTEDTLLSAMEHASAKEFAKLEDVEHKGLGTPATRAGVIEKLVRSGFVERKKKQLFPTEKGTELIKVMPDTLKSVKLTAEWEERLGAVERGELSPEDFMAGITAMLTELVKSYQGVTVASAALSASGRTVIGICPRCGKNVVEGKKSFFCEGWNAAPACDFALWKNDRFFTSKHKELTRKAAAALLKKGRVAMTGLFSEKKGVLYDAIVVMEDTGEKFVRFKLEFDNNTPKKKGN
(841) DNA topoisomerase 1 [Enterococcus faecalis V583]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQEKWVEVVDRFYKPFEKELTNAEEKIEKIQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVTCPVCHEGQVIERKSKKNRIFYGCSRYPECDFTSWDKPVGRPCPKCGQYLVEKKVKGGKQVVCINGDYEENVQK
(27) DNA topoisomerase III [Enterococcus faecalis V583]
7
MQLVIAEKPSVGMALSKVLGAKSRGDGYMEGGGWLVSWCIGHLVELAPADAYDPRYSKWNYADLPILPKPWQFQVLPDTKKQFEVLKTLIHRADVTALICATDAGREGELIFRLTYHLCGCTKPVKRLWISSMEEAAIQKGFDNLLDGKNYDNLYAAALCRAKADWLIGINGTRLFTTLYQGKSLNVGRVQTPTLALLAEREAAISGFQKEKFYTVELELEGFRAASERFASKTDAGRLRTGCVGKPATVQTVSQKEKTERPPKLYDLTTLQREANRLFDYTAQQTLDYLQALYEKRLATYPRTDSRYLTEDMAAGLPALCQSVAAALPFAADLSLPVNAAQVIDNSKVTDHHAILPTTEAAKTDLSALPSGEKNILFLVAARLLCAVGEPHTYAETAVTLECGGAVFSAKGKTETAAGWTAMEQAFHATLKKKPKQPEPSPPLPALTKGQKLTAGGASIKEGATSPPAHFTEDTLLSAMEHASAKEFAKLEDVEHKGLGTPATRAGVIEKLVRSGFVERKKKQLFPTEKGTELIKVMPDTLKSVKLTAEWEERLGAVERGELSPEDFMAGITAMLTELVKSYQGVTVASAALSASGRTVIGICPRCGKNVVEGKKSFFCEGWNAAPACDFALWKNDRFFTSKHKELTRKAAAALLKKGRVAMTGLFSEKKGVLYDAIVVMEDTGEKFVRFKLEFDNNTPKKKGN
(1317) DNA topoisomerase [Enterococcus faecalis V583]
7
MVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILEYVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALTVKYQDNLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTISLSVESEKAKMTQKNPYALKERQEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAEQPLSTVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLGTPATRAEIIEKLIKSELMERTNSGLSVSAKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVCTNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMTKHEERRLMKKYSQPDEPEESALAQALKAAMNQE
(840) DNA topoisomerase 1 [Enterococcus faecalis V583]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQEKWVEVVDRFYKPFEKELTNAEEKIEKIQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVTCPVCHEGQVIERKSKKNRIFYGCSRYPECDFTSWDKPVGRPCPKCGQYLVEKKVKGGKQVVCINGDYEENVQK
(1316) DNA topoisomerase [Enterococcus faecalis V583]
7
MVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILEYVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALTVKYQDNLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTISLSVESEKAKMTQKNPYALKERQEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAEQPLSTVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLGTPATRAEIIEKLIKSELMERTNSGLSVSAKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVCTNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMTKHEERRLMKKYSQPDEPEESALAQALKAAMNQE
(1550) DNA topoisomerase 1 [Enterococcus sp. 7L76]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQKNGLKLSIASTSPSKKN
(1313) DNA topoisomerase [Enterococcus sp. 7L76]
7
MSTVILAEKPSQALAYASALKQSTKKDGYFEIKDSLFTDETFITFGFGHLVELAEPGHYDEKWQNWKLESLPIFPDRYDFEVAKDKGKQFKIVAELLKKANTIIVATDSDREGENIAWSIIHKANAFSKDKTFKRLWINSLEKDVIRSGFQNLQPGMNYYPFYQEAQTRQIADWLIGMNASPLYTLNLQQKGVQGTFSLGRVQTPTLYLIFQRQEAIENFKKEPFFEVEASINVNQGSFKGVLSPTQRFKTQEELLAFVSSKQAKIGNQEGIIADVQTKEKKTNSPSLFSLSSLQSKVNQLYKATASQTLKAMQGLYEAKLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQVPTESALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDVQTLPLVIIGEHAEVDVKSAEKETQPPKAFTEGTLLTAMKTANKTVDDEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIKNKLVVTEKGKLLCQAVESQHLLTSAEMTAKWETYLKKIGKREGNQENFINNIKKFIVHLLEAVPTDIEKLSFADYQVQKEKEAEKSIVGKCPKCGNNIVLKKSFYGCSNYPECKFTLAEHFRKKKLTKTNVKELLEGKETLVKGIKNKEKKPYNAVVKIGEKGYIDFISFSK
(1719) DNA topoisomerase [Melissococcus plutonius DAT561]
7
MIKKQLIIAEKPSVAKDLSKVLGANQKNKGYFEGDTAIVTWALGHLLGLKMPEEINKEWQSWQMTTLPMLPKHLGIKPLPKTGQQLKTIKQLVNRKDIKEIVIATDAGREGELVARWILEYTHVTKPIKRLWISSQTDKAIKEGFKHLRPAKEYDHLYYSALARAKADWLVGLNVTRALTVKYQDSLSAGRVQTPTLALVRQQEKDISAFQAQTYFTISLQVADEKAKMVQKNPYSLKTRNEAELLVNKWNQQIGKVTDIKEKLKVESAPLPYDLTEIQKEANQRYQFSAKKTLSLVQSLYEVHKIVTYPRTDSKYLTTDMKETMNERLLAIREFDPIVKEYIKTGSQVKQTKVFQNAKVTDHHGLIPTEQRPNYTKLSNDEQKIYTMIVYRFLSLFAGPYKVAQTKITVTFGEQSFIFNQNKVESLGWRRETLEEKKKVSWKIGMTVSPKFSIQKELTSPPKPLTEGTLLAKMEKYSLGTPATRAEIIEKLIRSELMERTSQGIAVSPKGRQLLELVNPSLVTPELTEKWEKELEAIALGKQSSQNFLKEIETDTKKLVSEIKNSQKSYQDFSITQKKCPECQTNLKEKNTKEGKIYSCPNSECSYRRRKDPKLSNHRCPQCHKKMLIMDNQKNAYFKCKYCSITEKMLDKKNKKQKLTKQEERRLMKKYTKSETPQESALAQALKAAMSEKNPNH
(434) DNA topoisomerase 1 [Melissococcus plutonius DAT561]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENDYAPHYISIRGKGDVIKSLKTAAKKADKVYLAADPDREGEAIAWHLSYLLGLDPNEKNRVVFNEITKEAVKAAFKEPRTINLDLVNAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKIIIDREKEIKEFIPEEYWTIDGNFQKGRKKFKASFWGIEGKKKKLPKADSVKEITDKLKDDKYQVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMIAQQLYEGISLGKKQGTVGLITYMRTDSTRIAASAKVEATEYIEQTYGKEFSIQEERKVKKAQGTQDAHEAVRPSSVLRTPDSIKEYLNKDQLKLYTLIWSRFLASQMAPALLDTMKVTLEQNQVMFIANGSKIKFKGFMQVYIEGRDDGKEEKENILPELVEGDSVTSINIEPKQHFTQPPARFSEATLIHNLEENGVGRPSTYAPTLETIQKRYYVKLTNKRFEPTELGEIINTLIVDFFPQIVDVHFTAAMEEDLDKIGDGKEEWITVVDRFYQPFEKELTNAEEKIEKIQIKDEPAGFSCEECDHPMVIKLGKYGKFYACSNFPDCRNTKPIVKEIGVRCPICHEGQVIERKSKKNKLFYGCSRYPDCDFTSWDKPVGRLCPKCGKYLVEKKVKGGKQVVCINGDYEENVQK
(1759) DNA topoisomerase 1 [Tetragenococcus halophilus NBRC 12172]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHVRDLPKSKMGIDVENNYEPYYITIRGKGDVIKDLKKHAKKAERVYLASDPDREGEAIAWHLSYILGLDPHDKNRVVFNEITKDAVKEAFKEPRTIDLDLIDAQQARRVLDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDREKEIRNFTPEEYWSIDGNFKKGRKKFKANFWGLDGKKKKLPNEDAVKEVTQRISGKDYNVTKVEKKERKRNPAAPFTTSSMQQEAARKLNFRTGKTMMVAQQLYEGISLGKGGTTGLITYMRTDSKRISDTAKQEATDFIEQTYGKNYAAHSNKKLKNAQGAQDAHEAIRPTSAMRSPEEIGKYLDKDQLKLYRLIWSRLIASQMKPAILDTVKATLDQNGVIFVANGSKVKFKGFMEVYVEGRDDGKKDKENVLPELASGDIVQSEDITPNQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLQTIQKRYYVKLTQKRFEPTELGEIVDNLIEDFFPEIVDASFTAGMEEDLDHIEEGKEEWVKVIDRFYQPFEKELETAEEKMEKIEIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECRNTKPIVKEIGVTCPKCQKGQVIERKSKKNRIFYGCDRYPDCDFISWNKPIGRNCPKCDHYLVEKKKKASKQVVCSNCDYKEDEQK
(585) DNA topoisomerase [Tetragenococcus halophilus NBRC 12172]
7
MKQLILAEKPSVAKDLGRVLGANKKTKNYYEGPNVIVTWALGHLLGLKMPEDINKNWQTWQMETLPMIPKNIGIKPLPKTGQQLKAIKQLAHRKDIKEFVIATDAGREGELVARWILEWVHFDKPVKRLWISSQTNKAIKEGFKQLKPAKEYDALYESALARSKADWLVGLNISRALTVKYEDSLSAGRVQTPTLSFVRQQEKQIDKFRPQTYYVIELEVAGQKAARIQKNPYEIKEQQEAQNLITQMSQHAGAVVSVNEKNKTENAPLPYDLTEIQREANQRYGFSAKKTLSVVQSLYETHKVVTYPRTDSKYLTNDMKKTMKERLQAIANFSPEVKDYIKSGAKVEQKAVFNDAKVSDHSGLIPTEQGANPAKFSNDEQKIYNMIVTRFLTLFAKAHKKLQQKATVKFGDETFVFTQNKIIEAGWKGQEESEKNVNKWQEGQKIQPNFSIKKELTKPPKPLNEASLLAKMEKFSLGTPATRAEIIDKLLRSELMERTPSGLQVSPKGKQLLDLVNPSLVTPDLTKKWEEELEAIAQNKFSSKKFLAQIEKDTKELVNEVKNSQKKYQDFSITQKKCPECRSFLREKNTRNGKIYVCSNSECSYHRRKDPKVSNHRCPQCHKKMEIIEGKNGAYFRCKFDGITEKIPNKKEQKKKMSKQEEKRLLKQYSKPDEPEESPLAIAMKEAMNKD
(1062) DNA topoisomerase [Tetragenococcus halophilus NBRC 12172]
7
MSTVILAEKPSQALAYASALKQSTKKDGYFEIKDPLFTDETFITFGFGHLVELAEPGHYDEKWQNWKLESLPILPDRYDFEVAKDKGKQFKIVAELLKKANTIIVATDSDREGENIAWSIIHKANAFSKDKTFKRLWINSLEKDVIRSGFQNLQPGMNYYPFYQEAQTRQIADWLIGMNASPLYTLNLQQKGVQDTFSLGRVQTPTLYLIFQRQEATENFKKEPFFEVEASIKVNQGSFKGVLSPTQHFKTQEELLAFVSSKQAKIGNQEGIIADVRTKEKKTNSPSLFSLSSLQSKVNQLYKATASQTLKAMQGLYEAKLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQVPNESALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDVQTLPLVIIGERAEVDVKSVEKETQPPKAFTEGTLLTAMKTANKTVDNEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIKNKLVVTEKGKLLCQAVESQHLLTSAEMTAKWEIIESEQVIVRKDRLPAHFL
(1034) DNA topoisomerase 1 [Leuconostoc sp. C2]
1
MVEPGKVAKKPAAKKTTKRKKSKNQKKLVVVESPAKAKTIEKYLGSTYKVVASLGHIRDLPKSTLGVDVDNDYDPKYINIRGKGDLIKGLRKEAKAAKVVYLASDPDREGEAISWHLQHILGLDPDQPNRVVFNEITKDAIKNAFKTPRKINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIAREREIQAFEPEEYWSLDSEFQKSRQKFKATFYGFDAKKQVLPDNDSVQSVLKNIDQSADFDVMKVNAKERKRNPQPAFTTATMQQTANTQLNFRTRKTMMAAQQLYEGINLGRGIGQIGLITYMRTDSTRISSVARHAAAVYIHDTWGEEYSQHKLVQGKLPEGAQDAHEAIRPSDVTITPSSIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNGVIFRANGSKTKFQGFTKAYPAAKEKDNALPDLAEGDRVKLANINPEQHFTLPPARYSEAALIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVENSFPDVTNMKFTARVEHELDEIETGDKQWVPVIDSFFKPFSKELEIAETTLEKVVMHDELAGMDCDICGAPMLVKMGRYGKFHACSRFPDCRHTQTIVKEIGLICPKCGKGQIIERKTKRQRTFYGCSRYPDCDFVSWEKPTEKTLPDGTTPKDDEMSDGQQNSQQPTDNKEEAT
(1858) Topoisomerase IA [Leuconostoc sp. C2]
3
MPNYLILTEKPSAAANFVKALGGKTGTFNNFTYKITNLRGHVMTLKDPEEMVAEDLKKQYKSWLVKHLPWDLNDFSWERTYIRQRNMRTGKTESTKKIIDELKKEAKTGYDAIVIATDTDPSGEGELLAWEALDAIKWRGQVLRANFMDESATGVKTAMMNLRDVSDKQQDGEYIKGESRNRWDFASMQLTRIATTAAKKQGFKVVAREGRLKSVIVWQIYAQLLAIKNYVKKPYFEVKFKDPAGHIFGRVTPDGDVIPWRFSTKNDAQKDMTQYHESAVANEKHQTRTQAPGKLLDLAGLAAILAPRGFSAKEVLSTYQKMYEAQVVSYPRTEDKTVTPEQFNELLPKIDQIAQLVQVDTRLLTHRQPRPTHVKKQGAHGANRPGENIPTSLTSLTKFGPSAQAIYDILAKNYLAMLAEDYVYDHVTADLQDYPRFKTAFNIPIEMNFKAVYDSQRAVKVEDEVEDDNSGQLGPNAQPYLYEGANKKPQTPTTKWIMAFLEKHHVGTGATRVSTLSDMSRGTKSMIKETRGKLMLTETGNVSAVMVKDTWIASPKITKRLFEMMDQVGQFEITMPKLLDSITQVVEHDMPIMLSNADELELLLGKPKPALKRPVTEKITGVFKGEEITFAKSWSGHSFTDDELTKLLNGDEISFDAKSKRGKSYTAIGKMAKQTFKGRTFYGFKLNPK
(1396) DNA topoisomerase 1 [Erysipelothrix rhusiopathiae str. Fujisawa]
1
MKNLVIVESPSKSKTIEKYLGEDFEVVSSKGHIRDLATTGKGGLGVDFDNDFEATYKISKDKKDVVKELKAKAKKADAVYLATDPDREGEAISWHLANELGVDLDQDNRVVFNEITKDAVLSAFESPRHIDMNLVKSQETRRILDRIIGFKLSKLLQAKIKSKSAGRVQSVALKLIVDREKEIDAFTPEEYWSVLAFFENEGNIIETSAERFKGKKLKLTNEAEAQAVLDAAQGSFNITKLEKKKRKKESKLPFITSTLQQEASTRLGFPAKKTMRVAQKLYEGIQMGADTEGLITYMRTDSTRLSNVFVEDAKAFIVEEYGKEYLGKYRQGKKTENTQDAHEAIRPTSISRRPEEVKSYLTPDEYKLYRFIYYRTLASLMAPSISDSVSVVFSQNDYDFNGSGSIMTFDGYLKVYEYEKTTDKVMGELDETKAYNAQKIEKNQHFTQPPARYTEARLIKELEELGIGRPSTYSMILETIVYRAYATFGAVSETSKTKVFKPTDQGILTNEKLQEHFSDIINVHYTANMEDELDRIAEGEENNVEALQRFVDKFYPLLEEADEKMEKIEVEKVGEVCPDCGGELVYRFGRYGKFIACGNFPECRYNRALDQDKRPEPEKTGEVCPDCGEPLVKRKSRYGTFFVGCSGFPKCRYIQPNENAKKPKTKKPEEVSAEHEPLGEEIKD
(1270) DNA topoisomerase 1 [Leuconostoc mesenteroides subsp. mesenteroides J18]
1
MAETKTATKKKKAAPRKKSKIKKNLVIVESPSKAKTIEKYLGRNYKVVASLGHIRDLPKSTLGVDVENDYDPKYINIRGKGDVIKGLRKEAKAAKAVYLASDPDREGEAIAWHLQHILDLNPEQPNRVVFNEITKDTIKNSFKTPRVINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIAREREIQAFQPEEYWTLDSMFKKNRTKFKSIFYGFDGKKQPLPDNDSVQDVLKRINKDGDFDIVKVDTKQRKRQPQPPFTTSTMQQTANTQLKFRTRKTMMAAQQLYEGINLGKGLGQVGLITYMRTDSTRISSVAKNAAAQFIHDTWGEEYSQHKPVQGKLQEGAQDAHEAIRPSDVNRTPESIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNGVIFRANGSKTNFEGFTKAYPTAKKKDNVLPSLSEGDKVSLANTDPEQHFTLPPARYSEATLIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVEESFPDVTNMKFTAAVEHELDEVETGNKHWVPVIDSFFKPFQKEVEKAETSLEKIIMHDELAGMDCEVCGAPMLVKMGRYGKFYACARFPDCRNTKAIVQEIGLLCPKCHKGQIVQRKTKRGRTFYGCQRYPDCDFVTWDKPTEKTLADGTTPKDDEKKEPVKK
(1176) DNA topoisomerase 1 [Leuconostoc gasicomitatum LMG 18811]
1
MVETKNKTTKLVTKKTTKRKRAKVKKNLVIVESPSKAKTIEKYLGSSYKVVASLGHIRDLPKSTLGVDVENDYDPKYINIRGKGDVIKGLRKEAKAAKKVYLASDPDREGEAIAWHLQHILELNPEEPNRVVFNEITKDTIKNAFKIPRKINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIISRERKIQAFEPEEYWTLDSEFKKSRSKFKSSFYGFDGKKQPLPDNESVQYVLKQIDQSADFNIVKVEAKERKRNPQQPFTTSTMQQTANTQLNFRTRKTMMAAQQLYEGVNLGRGIGQIGLITYMRTDSTRISSLARNAAALYIHDTWGEAYSQHKPIQGKLPEGAQDAHEAVRPTDVTRTPESIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNNVVFRANGSKTKFQGFTKAYPAAKEKDNALPDLSVGDKVKLTNTNPEQHFTLPPARYSEAALIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVEESFPDITDTHFTASIEHELDEVEVGDKHWVPVIDSFYKPFSKEVEQAAATLEKVIMHDELAGMNCETCGAPMIVKMGRYGKFYACARFPDCRNTQTIIKEIGLLCPKCHKGQIVERKTKRQRTFYGCSRYPDCEFVSWDKPTEKTLADGTTPKVPEDEVSKA
(920) DNA topoisomerase I-like [Leuconostoc gasicomitatum LMG 18811]
3
MTNYLILTEKPSAAANFTKALGGKTGVFNDFTYKIANLRGHVMTLKDPEAMVAEELKKQYKSWLVKHLPWNLSDFSWARTYIRQRNMRTGKVESTKKLIDDLKKESKSGYDAIVIATDTDPSGEGELLAWEALDAIGWRGQVLRANFMDESVSGIQKAMHQLRDVSDKMADGEYVKGESRNRWDFASMQLTRIATTAAKKAGFKVVAREGRLKSVIIWRVYQQLDAIKNYVKTPYFEVKFKDPAEHVFGRVTPQGDVIPWRFATKEEAEIDFSQYHKTDVINEKHQTRTQAPGKLLDLAGLASILAPRGFSSKEVLSTYQKMYEAQIVSYPRTEDKTVTPEQFNELLPLIDQIADVVGVDKMLLTHRSPRTTHVKSQGAHGANRPGENLPKTTQSLVKFGASGPAIYEVLAKNYLAMLAEDYVYDHVTANLKDYPEFKTAFNRPLKMNFKLVYDSQKAIKVEEEEEENSTASQLGPQARPYLHEGANPKPQTPTTKWIMAFLEKHNVGTGATRVSTLSEMSRGIKAMLTETRGKLGLTETGQVSAIMVKDTWIASPKITKRLFEMMDQVGQFDMTMDQVLDSVTKVVEHDMPIMLDNAEQLETLLGKPKQVPKKKVTEKMTGLFKGEEITFAREWSGHIFTDDELTKMLNGAEISFQSKSKRGKIYTATGKLAKQTFKGSTFYGFKLNPKAKK
(592) Dna topoisomerase i (Omega-protein) [Leuconostoc kimchii IMSNU 11154]
3
MPNYLILTEKPSAAANFVKALGGKTGTFNNFTYKITNLRGHVMTLKDPEEMVAEDLKKQYKSWLVKHLPWDLNDFSWERTYIRQRNMRTGKTESTKKIIDELKKEAKTGYDAIVIATDTDPSGEGELLAWEALDAIKWRGQVLRANFMDESATGVKTAMMNLRDVSDKQQDGEYIKGESRNRWDFASMQLTRIATTAAKKQGFKVVAREGRLKSVIVWQIYAQLLAIKNYVKKPYFEVKFKDPAGHIFGRVTPDGDVIPWRFSTKNDAQKDMTQYHESAVANEKHQTRTQAPGKLLDLAGLAAILAPRGFSAKEVLSTYQKMYEAQVVSYPRTEDKTVTPEQFNELLPKIDQIAQLVQVDTRLLTHRQPRPTHVKKQGAHGANRPGENIPTSLTSLTKFGPSAQAIYDILAKNYLAMLAEDYVYDHVTADLQDYPRFKTAFNIPIEMNFKAVYDSQRAVKVEDEVEDDNSGQLGPNAQPYLYEGANKKPQTPTTKWIMAFLEKHHVGTGATRVSTLSDMSRGTKSMIKETRGKLMLTETGNVSAVMVKDTWIASPKITKRLFEMMDQVGQFEITMPKLLDSITQVVEHDMPIMLSNADELELLLGKPKPALKRPVTEKITGVFKGEEITFAKSWSGHSFTDDELTKLLNGDEISFDAKSKRGKSYTAIGKMAKQTFKGRTFYGFKLNPK
(529) DNA topoisomerase 1 [Leuconostoc kimchii IMSNU 11154]
1
MVEPGKVAKKPAAKKTTKRKKSKNQKKLVVVESPAKAKTIEKYLGSTYKVVASLGHIRDLPKSTLGVDVDNDYDPKYINIRGKGDLIKGLRKEAKAAKVVYLASDPDREGEAISWHLQHILGLDPDQPNRVVFNEITKDAIKNAFKTPRKINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIAREREIQAFEPEEYWSLDSEFQKSRQKFKATFYGFDAKKQVLPDNDSVQSVLKNIDQSADFDVMKVNAKERKRNPQPAFTTATMQQTANTQLNFRTRKTMMAAQQLYEGINLGRGIGQIGLITYMRTDSTRISSVARHAAAVYIHDTWGEEYSQHKLVQGKLPEGAQDAHEAIRPSDVTITPSSIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNGVIFRANGSKTKFQGFTKAYPAAKEKDNALPDLAEGDRVKLANINPEQHFTLPPARYSEAALIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVENSFPDVTNMKFTARVEHELDEIETGDKQWVPVIDSFFKPFSKELEIAETTLEKVVMHDELAGMDCDICGAPMLVKMGRYGKFHACSRFPDCRHTQTIVKEIGLICPKCGKGQIIERKTKRQRTFYGCSRYPDCDFVSWEKPTEKTLPDGTTPKDDEMSDGQQNSQQPTDNKEEAT
(1032) DNA topoisomerase 1 [Peptoclostridium difficile 630]
1
MAKTLVIVESPAKAKTIEKFLGKSHYTVKASVGHVRDLPKSKLGVDIENNFEPQYINIRGKGDVIKELKKEAKKSKQVYLATDPDREGEAISWHLAHILNLDESEDCRIEFNEITKDAIKKAIKHPRNIDINLVDAQQARRVLDRLLGYQISPILWQKVRKGLSAGRVQSVTTKLICDREKEIKAFIPKEYWTIDVEAKTVKDKDITLKFYGKNDEKIELENEEAVNEILKEMEGKDLKVEKIESKSRRKSAPKPFTTSMLQQEGANKLFFTTKKTMMIAQELYEGIDIEGEGTVGLISYIRTDSKRISDEAKEKAKGYIVNNLGENYYKNTGDKKEKKDTKKVQDAHEAIRPTSVDRTPESIKASLSKDQYKLYNLIWRRFVASQMEDSVFDILNVECKIGDIVFKATGSKMKFDGYTKVYNFSEREDKILPSIEKGDILNIENILPDQHFTQPPARYTEASLVKTLEELGIGRPSTYAPTIATILNREYVEKQGTSLCPTELGIIVTDILENNFHKFIDVDFTADMESKLDVIEEGNTDWKKIVSESYAPLKEAIEEALENIEKVNMDEETDEICENCGSNMVIKYGRFGKFMACKNYPDCKTTRPIMNKIGVKCPKCEEGDIILRKSKRGKAFYGCSNYPNCDFVAWNKPTGEFCEKCGSYMVEKVTKSETKTVCSNKECNKETKEHNDGKE
(28) DNA topoisomerase [Peptoclostridium difficile 630]
7
MKLVIAEKPSVAISIAKVIGATKKKDGYYEGNGYKVSWCVGHLIQMANPESYDEKYAKWNMADLPIIPREYKYEIAKSTKKQFTILKKLMNDKEIDIVINACDAGREGEAIFRLVYNQANCKKKMKRLWISSMEDSAIKEGFDNLKDGSFYDNLFESAQARAIADWLVGMNLSRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEIANFKKEKYFTVELDLDGFSLSTDRIDDKTVTEQLINLLGNSIEITDVIQKEKITKPELPFDLTTLQRECNKYFNYSAKQTLDYTQSLYEKKLITYPRTDSRYLTEDMITSTINNIVGKHDFDTGRIKMVFNSKRVTDHHAIIPTASSMNEDLASLPESELKVYELVLNKLHASVGYPLIENTTKIVAVFDGFEFTSSGKVIVDEGFTKYLKKYIKKKNEDTVFPDLKIGDSLDIKEKEIKENYTSPAKHFTEDTLLKDMELAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVSDTFKSAGTTAKWEMELSDIAQGKASKENFLKAIENEIKELVSTYSK
(573) DNA topoisomerase [Peptoclostridium difficile 630]
7
MILVIAEKPSVAQTIAAVLGVKEKKDGFLTGSGYIVSWCVGHLVGLAEAAAYGEQYKKWNYDSLPILPQEWKYTVAADKEKQFKTLKELMHRADVSEVVNACDAGREGELIFRFVYEMAGCKKPMRRLWISSMEDSAIKEGFSRLKNGKEYDALFASALCRAKADWLIGINATRLFSVLYNHTLNVGRVQTPTLKMLVDRDAAITTFKKEKYYHVRLALSGAEAASERISNKAEADTLKTTCEASKAVCTSLLKEKKTAAPPKLFDLTSLQREANCLFGYTAKQTLDLAQALYEKRLLTYPRTDSSYLTDDMGDTAAGIIKLLCGKFPFMAGKDFTPELAKVLNSKKVSDHHAIIPTMELAKTDLAALPESERNILTIAGARLIMATAAPHTFEAVTAVFECAGQSFTARGKTVLSDGWKEIDRKYRAILKSKPETDDADSDTEKTLPPFTEGQNFDNPAAKVTEHDTTPPKPHNEASLLSAMERAGSEDTDPDAERKGLGTPATRAAVIEKLVKGGFVERKGKQLLPTKDGINLVCVLPDTLTSPQLTAEWENNLTQIAKGKADPAAFMKGIEDMARELVKTYPFLSEADKGRFKEEKPELGKCPRCGSPVYEGKKNYYCSNKECSFTMWKNDRFFEERKVTFTPKIAAALLKSGKVNVKKLYSPKTGKTYDGTIALADTGEKYVNYRIELSKKK
(1711) DNA topoisomerase [Peptoclostridium difficile 630]
7
MKLVIAEKPSVAISIAKVIGVNKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYAKWNMADLPIIPSAYKYEVAKATKKQFNILKKLMNDKEIDTVINACDAGREGESIFRLVYNEAKCKKKMKRLWISSMEDSAIKEGFDNLKDGKGYDNLFESAQARAIADWLVGMNISRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVELSMNGFTLSTDRIDDEVAAEQLINLVGDKIEITDVIQKEKITNPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYPRTDSRCLTEDMITSTINNILGKNDFDTGRIKTVFNSKKVTDHHAIIPTISSLKEDVSKLPLSEAKVYFLISDKFHASVGYPLIENTTKIVASFDGFEFTSSGKVIKDEGFSKYLKEYKSKKNEDAVLPNVSVGDVLSIENKEIKEKFTKPPKHFTEDTLLKSMEIAGNDALEKGVEVERKGLGTPATRAGIIENLIYKGFVERDKKNLIATHKGISLVTIVADNFKSAETTAKWEMELSDIAQGKSSKKEFLDAIENEIKEAVLTYRK
(918) DNA topoisomerase [Peptoclostridium difficile 630]
3
MKLVLAEKPSVAKTIASFLGAKTRQDGYFEGNDYIITYAVGHLVSLYDMKDYDKDKYSGSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVINATDNDREGELIAFLIFLLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAAGYTRLITDWLIGINFTSVATLKYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYYEIEGHFKAEAGEYKGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAPKLFSLTSLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASKASQTLDKLKVGLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPKSLSKDEQLVYDAIKDRFVANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKNDLLPLVNKDDVVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDTTVLSGYSIGTSATRADVLKKISQVGYVKKKGKSYSITELGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGKYTRKEYLTNIISFIYQNVNIIKQDASKNINTEAYTFDSKTKKFTKTKEKKQKKDVTNTEKEVAISKDSNNKKEVKNGDENQSLGKCPICQGDVLEFDKGFACKNHKECKFVIWKNDKYLSLYKKKVNKTMVKNILKKGETKVKSLTAKNGNKFDATLKYDKNPDTGYFNWKIEFDN
(1879) DNA topoisomerase 3 [Peptoclostridium difficile 630]
2
MGKILVLAEKPSVGRDIAKVLGSKNEKNGYIEGPKYVITWALGHLVTLADPESYGERYKSWSLEDLPILPKHLKTVVIKKSGKQFNTVKSQMNRNDIDEIVIATDAGREGELVARWIIEKSQVKKPIKRLWISSSTDKAIKDGFAKLKSGKEYENLYYSAIARAEADWIIGINATRALTTKYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLELIATKGNSDIKFIWNDKNNNSSTFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPALYDLTELQRDANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIKAVNISDYSKICNRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVFMSDFSDKERKIYNLVVKRFLAVLSPPFEYEQTTISATVEGEIFKAKGNKVINLGWKESYKDIEDEDEYESIPNVLEKDVLKVKGLKITSGKTNPPPYLNEGTLLTAMEKNGLGTVATRADIIEKLFNSFLMEKKNKDIYITSKGRQLLDLVPVDLKTPELTASWEKKLLDISKGKLSKNTFINDMKDYSKDIVLEVKNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLICEDRECNTRKTISQVTNSRCPNCHKKLELRGEGEGRIFTCSCGYREKLSSFNKRKQEEKQKASKKDVNQYLKNQNKNQETFNNPFAEALAKLKNK
(1084) DNA topoisomerase 1 [Thermoanaerobacterium xylanolyticum LX-11]
1
MEKSLVIVESPSKAKTIHKYLGKNYKVEASMGHIRDLPKSQLGIDIEKNFEPKYITIRGKGPIIEKLKKEAKNASKIYLATDPDREGEAISWHLASLLNIDINEKCRIEFHEITKNAIQNAIKNPREINMNLVDAQQARRILDRLVGYNISPLLWKKIKRGLSAGRVQSVATRLICDREKEIEDFKPEEYWSISAYLYKEKKTQSFEAKFYGTKDGKVELKNENDVNEIVKDLTDDYVVENVKIGTKKRNPSPPFITSTMQQEASKTLGFTAKKTMMIAQQLYEGVEIKGEGSLGLITYMRTDSTRVSDEAKKAAYEYILQKYGKEYANPNATYAKKGGNIQDAHEAIRPTYIDLDPEKIKDSLKPDQYKLYKLIWSRFLASQMSPALYDTMNVDIINKNYVFKASGSKIKFSGFMAVYTDDDENENEDKMLPMLNSGDFLKLKELKPEQHFTQPPARYTEATLIKELEEKGIGRPSTYAPIISTLLERGYVIKEKKNLKPTELGFIVTDVMKEFFPDIVDVKFTAQMEEQLDRIEEGIEKWCDVIDEFYNGFNASLKIAEEQMKDIEIKDEETDIKCEFCGRNMVIKYGRYGKFLACPGFPECKNTKPLYEEIGVTCPKCGGKIIIKKSKKGKVYYACENSSNCGTMFWDRPISETCPKCGALLVEKHSKGRKIIKCSNCDYVK
(292) DNA topoisomerase 3 [Coprococcus catus GD/7]
2
MKTLVIAEKPSVGRDIARVLQCTRNSQGALEGEKYIVTWALGHLVTLADPEGYDAKYKSWRGEDLPMMPQHFKLVVIKQTHRQFQIVKNQLLRKDVGTIVIATDAGREGELVARWILKIAGNKKPVKRLWISSVTDKAIREGFKNLKDGRAYLNLYAAAEARAEADWLVGMNGTRALTCRYNAQLSCGRVQTPTLALIASREQEIKSFVPKKYYTLTTVSHGMTWNWQDGKSGSNRSFDRGRIQSIAEKAEKDEMVITDVQRTVKKSYSPGLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYIGKDVAETLKERLQACAVGPYRKVAGKLLLQPIRMDKRFVDDSKVSDHHAIIPTEQFVQLDHMSSEERKIYDLVVRRFLAVLYPPCEYEQIKLTGSCAGEKWTAGSRMMKEAGWQQAYESEWEEEDDDSLMTVTSMPKLEKGRKDTVMRPKVSEGQTKPPAYYNEGTLLTAMEKGNLGTVATRADIIDKLFNSFLMEKKDKDIRVTSKGRQLLGLVPEDLKKPELTADWEKKLLAISEGRLKKDVFISEIRGYTEEIVKEIAGGEGQFRHENLTNHLCPNCGKRMLSVQGKNSKMLVCQDRSCGYRESIARKTNARCPKCHKKMEMYGKGDAQTFVCTCGYKEKLSAFQNRRKKEGAGVSKRDVQQYMKRQQKEANEPINNAFAAAFAKLNLETKEGE
(1278) DNA topoisomerase [Coprococcus catus GD/7]
7
MYLVIAEKPSVSKAIAEVIGAQEREDGYLQGTDCMVSWCFGHLAEYVSPDAYDEKFNQWRYEDLPIIPKDWKVTVSEDKKDQFYILKRLLNSPEIEYVVNACDAGREGELIFKHVYDLSGSKKPVKRLWISSLEDSAILDGMQHLRSAEEYRHLAEAAVCRSQADWLVGMNATRAYTTKYFKKLTVGRVQTPTLAMLVERAGQISNFQKEKYFNVELDCDGIPAVKPKIFDPDEAEQLRSRCQGSEAIVTAVKETEKKVKAPKLYDLTTLQREANRIYGMTAKQTLDTAQSLYEKKLITYPRTDSQYLTEDMEQTARNVVRQIYEKYQLTGPFDQPEQPDVKKVMNNSKVTDHHAIIPTMELASCHLDELKSWEEKILFLIAVHTVMAMSKDHIYQETEIEVECQEEIFKAKGKIVLQDGWKLFENCFKNKDRMAIVDPDQEMKERMPKVTQGQTFYAVDAEKTEHFTSPPKPYSEDTLLAAMETAGNKEFDEDTEKKGLGTPATRAGIIEKLVYSQYATRKGKQIIPTDDGKVLVEILPDFLKSASMTAEWENQLLLMEHGEIAPEQFMTGIKNMLTMMLNGCDAISEEETRRFQTRESIGTCPVCGSLVYESKTNFYCSNHDCHFALWKDNRYLQSMEKNMDKKMAAELLKSGCVHVKDLYSRKKNMYFEADLHMDADETGRVKFSLSFPKKKPKNKSKKK
(1772) DNA topoisomerase 3 [Clostridium lentocellum DSM 5427]
2
MGKILVFAEKPSVGKDIARVLKCTQKQNGFFEGPKYVVTWAMGHLVGLSDPEAYGNQYKTWSMETLPMLPERMKLTVLKGTGKQFQIVKSLMLRKDIDEIIIATDAGREGELVARWTIDKVGVKKPIKRLWISSVTDKAISEGFKNLKPGKDYENLYKAAVCRAEGDWLVGLNVTRALTCKFNAQLSAGRVQSATLAMIVAREEAIKNFQPKPYFTLSAKCKGIQLAYKGKKGDRFFDEKQIVTLIGKLEGSKAQVTEYKETSKKQYAPALYDLTELQRDANKRFGFSPKETLSVMQRLYENYKVLTYPRTDSRFLSEDIVPTLKERINAIAIGPYKVGAREVLKNGIKSSKHFVDNSKVSDHHAIIPTEESPDLSKLNSDERKIYDLVVKRFLSVLLPPMAYNEGVLEVSSEGECFVAKGKKVIEPGWKMLYEIEADEDEDEVVQSLPEVKKGETVVLEQFFKTKQMTKAPSRFTEATLLSAMEKPHQYVEVDQKAAKTLGETGGIGTVATRADIIEKLYNMFYIEKSGKEIVPTSKGKQLIELVPVDLKSPLLTAEWEMALEQISKGKQDPKAFMKKIRVYSEELVQSVKGSGEKYIHDNLTGKRCPECNKLMLEVKGKHGKLYVCQDRNCGYRENISRFTQTRCPNCHKKLELRGEGEGQIYVCTTCTFREKLSVFNKKYRSESKKVDKKSVQKYLKEQTKKEEGNFAFAEAFAKLNK
(1795) DNA topoisomerase [Clostridium lentocellum DSM 5427]
3
MKKVIIAEKPSVAKNIADAFDIKTKRDGYYEGEDYLITWAFGHLLQLYDAKDYDESMKSWRLEKFPFIPEEFKYKVKSDGKNKAIEDVGARKQLNIIKDLIDREDVESVISATDFDREGQVIGDEIFLYFNEKKPIYRILLNEWTPEEVKKGISQLRPNEEMKSLQDAGIGRQWADWMIGINLTSVATVKYNSGSKKILNIGRVLLPTLKIIYDRDKEIEQFEASTYYKLLANFKTSQDEVFEGTYYEKDEEGKDNEKFDNKATLESMVELIKNKPAQIVEKQVEKKKEYAPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKYITYPRTGSLALEESLKGRTKKVLDTLKIGLPYEGQICFADHKRIFDNSKVESHSAIVPTYIIPKSLTPDEQVVYNAVKNRFLMQFLPIAEFEETKLITKIIDVPEESLKGVFISKGKVQLVEGWRIVEKFEAKGTKEGKENKDTLLPQVTQDELVEMKNANVAEVTRKPPKAHTEKTLLRVMETCGKSFKGDEKEEGKEESEEDTLKMMASILSGFSIGTPATRAETIKKLKDAEYIRAKGKSLVCTDLGKALVETFPAKQLLDLEYTGRLEKTLSDIEKGKFQKDEFLSMIKAFTEEAVEAIKNDTRVLSGTKVEVPKNMEPVGVCPVCGNAVVENEKAFGCVNWKSGCKYTIWKNDKYITMLGKNVTRQMVELLLKNGKVGFRNLKGRNGNTYAAYLKYVKNDQTGYFNWEQEFI
(440) DNA topoisomerase 1 [Clostridium lentocellum DSM 5427]
1
MADNLVIVESAAKVNTISRFLGKNYKVEASIGHVRDLPKSQLGVDTANNYEPKYITIRGKGELLQKLRKDVKNAKCVYLATDPDREGEAISWHLYHALKLQEKKVCRITFNEITEQAVKEAIKHPRDINTDLVDAQQARRVLDRLVGYEISPILWKKVRKGLSAGRVQSVTLRLISDRDKQIREFVEEEYWSITANLQQGKGKTFEAKLDTYKNEKCDINNEEEAKKIVKACKKGHFQVVSSKKGTRVKNTVLPFTTSTLQQEAAKHLGFSTQKTMNIAQQLYEGIKVGKKEVGVVTYIRTDSIRIADKAKEEATTYITQKYGEQYLGAKKQIEKAKKAHIQDAHEAIRPTYMEYEPNEIKEYLSRDQFRLYQLIWNRFVASQMAPAQYETYSIKVQNGDYEFKASYSIELFDGFIKVYNLGEEKAKKEAKFQVEEGEQLVCGSIIPNQHFTQPPAHFSEATLVKTLEENGVGRPSTYAPTITTLLARGYIVKESKILYMTELGEVVNQIMKEYFDEVVDVDFTANMERILDEIASGNVEWKEIIKSFYPHFHHTVEYAESQIENIDLTEHTDIPCEKCGTHMVVRYGKYGKFLGCPNFPECNGTKPWYEETGISCPECNGKILMKKTKKGRSYYGCEHNGEGCEFMSWDKPTGEKCPICGEALIEKGNSKNKKIVCRNSKCNYGKQNKN
(906) DNA topoisomerase 1 [Coprococcus sp. ART55/1]
1
MIRITGNLQKGQIAMAKNLVIVESPAKAKTIKKFLGSNYEVIASNGHVRDLPKSQMGIDVDNDFEPKYITIRGKGDILAALRKAVKKADKIYLATDPDREGEAISYHLMKALKLENKDYKRITFNEITKNAVKNSIKQARDIDMNLVDAQQARRVLDRLVGYKISPVLWAKIKRGLSAGRVQSVALKLVCDREKEINDFIPQEYWTLDANLTGGKLKKPITFKFTGDGKNKEEISGRAALDEILSGLQDGEYVVKSIKESERNKKAPLPFTTSTLQQEASSKLNFATSKTMRIAQQLYEGVDIKGRGTIGLITYLRTDSTRISEEAVAAADKYITDNFGEIYIGDSNGRAKTDKKIQDAHEAIRPTDVTLSPVMVKEQLSRDQFRLYQLIYNRFLASQMAGAVYSVKSVKVSCGDATFQTSASKIAFDGFLAVYNLDNDRGETVAGINNLAEGDVLELDGFEEKQHFTQPPARYTEALLVKTLEELGIGRPSTYAPTISTILARRYITKEQKKLYVTAIGDAVNQSMEQAFPVIIDVNFTANMESLLDKIGEGTVDWKVVVRNFYPDLDEAVKKAEAELESIKIEDEVSEEVCDVCGRNMVIKYGPHGKFLACPGFPECRFTKPFYEKIGVTCPKCGGDVVIKTTRKGRRYYGCINAPECDFMSWAMPSNEKCPECGKYMIVKGNKLVCSDQECGYTCNNKAAETADK
(460) DNA topoisomerase III, bacteria and conjugative plasmid [Coprococcus sp. ART55/1]
7
MQLVIAEKPSVAKSIADVLGALDRQDGYFEGGGYLVSWCVGHLIELAEPESYGEQWKKWTYESLPVNPEHWQYEIKEDTKEQYDVLYGLLHDSRVDEVVCATDAGREGELIFRLVYNMASCKKPMKRLWISSMEESAIREGVENLKPGSDYDHLYHSALCRQEADWLVGINGTRLFTVLYGGKVLKVGRVQTPTLAMLVEREAKIMNFKKEQYFMAHILCGGVDAVTERIDNKTEAENVAGACRNGQALVTSVEKEEKTVSPPKLYDLTTLQRDANRLFGFTAKQTLEYTQSLYEKKMCTYPRTDSQYLSDDMEQTAGNVIEAIFSSILFEENRMFNPDIKRVLNSKKVTDHHAIIPTMEIAKADLAALPETERKILSLVANRLLCATGEKHLYETVKAELSCGGYTFTTSGKSVLKNGWKDFEDAFKRSFKATEEKEQEDKKLPELSEGQTFDGVQTKISEHYTTPPKHFTEDSLLSAMERAGNEDMSDDVERKGLGTPATRADIIEKLVKDGFVKREKKQMLPTEDGMKLITVLPDVVKSSKLTADWENALTLVAKGEMEREDFMADIETMESDLIHTYHEVSDEQKKMFAQEQKVLGKCPNCGGEVVKGKYGAFCKNKCGMNVSRIMGVALSDEQVESLLAGKKTLLKGITSKAGKKYDAYIIPSGTEEYHYTKDGEEKSGAQFKFVMEFPNKKFTGKKK
(285) DNA topoisomerase 3 [Ruminococcus sp. SR1/5]
2
MKSLVIAEKPSVARDIARVLHCSQKGNGTLEGKAYVVTWALGHLVTLADPEEYDKKYTKWELSTLPMMPEKMKLVVIRQTSKQYNAVKTQLYRKDIGEIIIATDAGREGELVARWILAKADCHKPIKRLWISSVTDKAIRDGFAHLKNGHDYDDLYRAAQARAEADWLVGMNGTRALTCKYNAQLSCGRVQTPTLAMIARREQEIREFKPEDYYGIILQAGNVRWTWRDGKSGSLRTFKKERAQEIQTKAGKSSLTITKVSRKPKKTYAPGLYDLTTLQREANQKYGFSAKETLNIMQRLYENHKVLTYPRTDSRYIGKDVVPTIKERLQACGTGPYRKLAGALVNKPIQTSAGFVDDKKVSDHHAIIPTEQFVQLDHMTNEERKIYDMVVRRFLSVLYPPAVYELVSMEGTAAGETFAASGRIVKSAGWREVYEGGWQDEDEEESGDKLKDQKLPELTEGQILTVEGAALTAGKTKPPARFTEATLLGAMENPVHFMESHDKKAAKTLGETGGLGTVATRADIIEKLFNSFMMEKRGNEIYITSKAKQLLELVPEELKKPELTADWEMKLSDIANGKLRQDKFLTGIRKYACEIVDEIKGGQGTFRHDNMTNKKCPNCGKHLLAVNGKNAKMLVCEDRECGYRETVSRTTNARCPKCHKRMEMLLKGKEETFVCQCGYKEKLSSFQARRAKEGAGVNKRDVQRYLKKQQKEANEPVNNAFAQALSGIKLD
(1434) DNA topoisomerase 1 [Acetobacterium woodii DSM 1030]
1
MIKTLVIVESPAKAKTIKKYLPKGFEVEATMGHVIDLPKSRIGINIENNFAPEYIKIRGKAALLKSLKSAAKKADQVYLATDPDREGEAISWHMANFLEIDLTTKCRIEFHEVTKKAVNAAIENKREIDIDLVNSQQARRILDRLVGYSLSPFLWKKVKKGLSGGRVQSVVTRIIVDREEEIEAFIPEEYWNLELLLKKTDDPIEFISKFYSEDGKKKTITIAEEAQRLEKIVDANAIIVDKVKKRIRYQKPPVPFTTSTLQQEAYKVLGYTTQRTMRLAQQLYEGVEIKGSGLTGLITYLRTDSTRIADEAVLESKAYIKQHFGDEYLGSEKKVGKKKNVQDAHEAIRPSSIMLTPEKAKESLEPDQYRLYKLIWERLLCSQMSDAQYYVTDVDIACNNLIFKTKGETQKFDGFTRVNRNPNKSEDSILPELSVGDDLIRLKTTKEQKYTKPPARYTEASLVKILEEKGIGRPSTYAPTIATIKNRDYVEVIEKHFKPTELGVTVTHLMKEYFSDVVNISFTADMEDRLDSVSEGKTDWVELLRNFYGDFEKALTNAQEKAEAVTIADPESDEDCELCGRRMVIKKGKYGRFLACPGFPECKNTKPFFEKTGGICSLCGGDIVKRTSKTGRTFYSCNNYPDCDYMNWDMPIPEKCPVCGSTLFQKGLGKRKSIYCDKKDCGYKAAPKE
(1351) DNA topoisomerase [Desulfosporosinus orientis DSM 765]
7
MKRTLIVAEKPSQAREYAVALGVKRKGDGYLENDQYVITWCYGHLLELERPEAYMDLEQVGRRWSLRRLPVLPSLNDFRRVVKKESAKQYQVVLNWLSSSEITQVICGTDADREGQLLFQEIWDAANCRKPLSRLWISSLTTAAIREGLKNLRSAETVAGLAAAGNGRAFADWDFGMNLTEGFTALFGSFDTERKRPNVISIGRVQTPTLALIVEREWEIESFVPQQFYEVKAEFKAEQGNYYGKWIDPGDDTKRITDLQEAESIVLKTQGKLGSISEMEEKEILEPAPLLFDLTSLTIAGSKKYGYSAEKVLQLAQSLYEKKAITYPRTDCAYLSEDILPKLPAHLNAVCQEPYKDLADQARGFGLPKGKRVINTITAHHAIIPTTEKVVLERLNRDEQHLYDLIVRRFLAVWFPPARYYQTVVMTLVESETFRTKGKALLSLGWKAVYDHSDLKKHGSAGEEEEAALPPLLKGQVVQVKEVSWDEKSTKPPKPYTQGDLLKAMEGAGKQIDDEILRQQLKGKGLGTVATRPAIIESLIDRGYIFQKQKSLRPSAKGVELIRLIKEKLPEAHLLISAEMTGQMEYNLAKVEKGEIPIQSYMSEVENSVKRIVAELRSFEQCHGKSPLAFAPAVKVSRKGKKKEEGEKTVRQKEKTSDSSAQSLGKCPKCGSEVIEGQKGFGCSNWRSGCRFVLWKTPICGKTLTPNQIRRLLKTGKTPLIKGFKSKSGQSFAAYLIWENPAEAKLTFRFKKE
(1694) DNA topoisomerase 1 [Desulfosporosinus orientis DSM 765]
1
MSKTLVIVESPAKAKSISKFLGSRYTVKASMGHLRDLPKSQMGVDLENDFEPKYIAIRGRGDLIKELRAAAKSADRVFLASDPDREGEAIAWHLSYLLGLEQTDKIRIEFHEITKQAIQTAIKHSRHIDQDRVDAQQARRVLDRLVGYQLSPLLWRKIKKGLSAGRVQSVAVRLIDDREEEIRAFVSEEYWSLTAELQFAGGKFLAKLVKKSGKKISISNRTEMETVLEELKGKEFKVSDVRTKEKKRLPAPPFTTSSLQQEAHRKLGFSPKRTMMLAQQLYEGLDLGKEGTVGLITYMRTDSVKIADIAQTEAKEWILGNYGGDYYPPEPRQFTTKGRAQEAHEAIRPTLPLRTPDALKGILSRDQLRLYRLIWERFMASQMSVAVVDTLTVESLVDEYLFRANASTVRFPGFLAIYEEGNDDTEAKDEEQNSLTISVSPGEQLKLIKLQEKQHFTEPPPRYTEASLVRKMEEEGIGRPSTYAPTIETIQTRGYVVKEEKQLLLTELGDIVITLLKEHFPDIVNLEFTANLEEKLDLIEEGKAPWKAVVEEYYQPFSVTLAEAEEKIGKVKIEDQVSEEICENCGRNMVIKMGRYGKFLACPGFPECRNTKPLFEEVGTPCPNCSKPLVVRRSKKGRKFYGCLGYPECDFVSWEMPAPEPCPECGQLMVVKSTKRQKKHVCTNRECRHTIVIEEEG
(1129) DNA topoisomerase 3 [Desulfosporosinus orientis DSM 765]
2
MGKTLVLTEKPSVGREVARILHCNQKGKGCFIGPNYVVVWALGHLVTLADPELYDEKYKDWKMEDLPMLPDKMELVVMKETAKQFGVVKNLMRSQEFSDLIIATDAGREGELVARWIIKKAGWKKPLKRLWISSLTERAIKEGFQHLKPGKEYEALYAAAECRAEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREQEIKNFVPKDYWTINLRARGFNLRWQDSNGQTRIFAKEKAEALAAKLKGHSGEVVEVKRDAKKELPPLAYDLTELQRDANRKYGFSAKTTSSVMQQLYENHKLVTYPRTDSRYISEDMVSTLPERLKSIALGPYVNLARGILRNKPIVTKRFVDGSKVSDHHAIIPTEQPPALSRLNSEELKIYDLIVKRFLAVLSAPFEYEQTLVKVAVQKEVFTAKGKIVKKLGWRSVYEGQGTWDDDSDDGEKEAEQTLPEISRGEILSNLSVDLASGKTKPPSRHTEATLLSAMEHPGKLIGDQKLREAMEQSHGLGTPATRAEIIEKLYNSFYMSRQGKEIVPTSKGIQLIGLVPAELKSPVLTAKWEQQLTEISKGKVNSQAFLKGIRGYTIQLVSTVSGSTQTFKHDNLTRNKCPECGKYLLQVKDKKGEMLVCQDRECGYRKRLTQISNARCPECHKKLELKGDGENKFFSCVCGYREKLSVFTKRREAEKGKMNKKDVSRYLHNQKDDGPINTALADALAKFKKQQ
(1714) DNA topoisomerase 1 [Eubacterium limosum KIST612]
1
MAKNLVIVESPAKAKTIKKYLPKGYEVQATMGHVIDLPKSRIGIDIEDHFKPDYIKIRGKGELLKKIKKEANKADNVLLATDPDREGEAISWHVANFLGIDLDTKCRIEFHEITKRAVNAAIENKRAVDMDLVDSQQARRILDRLVGYSLSPFLWKKVKKGLSGGRVQSVVTRIIVDREEEIAAFVPEEYWGLDLELKKDKDKNIFLSRFYSEDGKKKTIKNAEEAARLEQVVLHNPITVAGVKKRVRKQKPPLPFTTSTLQQEAYKVLGFTTQRTMRIAQQLYEGVEVAGKGLVGLISYIRTDSTRLADEAIAEAKDFIETNYGPDYQQSSAKKTVKKKNVQDAHEGIRPSSVFNLPEEVRDSLEKDQYKLYKLIWDRMVASQMADAEYYVTDVDVACANLLFKTKGEIMKFKGFTAVYRTASSAEKEEANRLPEFEDNEELNLVKINKEQKFTKPPARYTEASLVKILEEKGIGRPSTYAPTIATIKSRDYVEVVEKHFVPTELGITVTHLMKEYFEDIVNLTFTAEMEEKLDKVADGETDWVKLLESFYGGFKKELDHAQEAAAEVTIADPESDEICELCGRRMVIKKGKYGKFLACPGFPDCKNTKPYFEKTGGICPECGGDLVKRTSKKGRTFYSCSNYPNCEYMSWDMPVAEKCPECGQTMFQKGLGKRKKVYCAKCGFEKSADQQ
(423) DNA topoisomerase [Eubacterium limosum KIST612]
3
MKDLILAEKPTVAVNIAKAVGMTSRKDGYFENSQYVITFAVGHLLELYDVKDYHPEYGEKWEISHYPFVPDTFKYKIAESTRKQFKIVKDLILSDEIQEIISATDNDREGQLIADLIFRYLGVKKPIRRLITNEWTTDAIRYGLKNTVPNKSKQSLFYAGLVRQQMDWLLGINLTSVATLKLLKNGTGKDTLHIGRVILPTLKLVYDREMNVKNFKSIPIYYLNAYVKDVSGEEIIFRYIEGDEKIYKFDHDSHLVQILRLINTETAVVVGYECSEKKMNPQRLFSLPTLQGHITTKYEGWSSDKVLKIAQKLYENKLITYPRTDSVYLDETLKENMSMVLNIHKIESQYAEMLQFKDTKRIFNSEKVESHSAITITKEKPRGLSQDEHIVYEAIRNRFLEQFMPLAIDEEVEVTLAFEGKVPSEDGAFLFSAKSIVERSPGWRLIENRNATKKETLLTRMRENESVTIDRVMVNKGETKPNPLHTEETLIKAMLQCGKKYKTEDELETSILSGFTIGASSSRAAVIKKLFDSDYVIKKGKSLVTTDRGKSLIQAFPVKSLFNVETTGKMEMRLKDIEEGKADPRAYLEDVKIKTKEYVQMILETEQFVLNAGEDISIKELRCPKCGKPLHKTKSGVGCTGYEKEGNGCDFFIANPFAGKTLSNRQIALLVINKKTPIIRGFKSKKDTKFDAMLALNHQYEIKFEFQKSETDLACPLCGKPLKRNKAGMGCSGWKEGCKFMIFNPYCGKRLSDNQIEQLIKRGHTGEIKGFKKKSGNGTFSAILYLDDSDQYKVKMKFE
(1648) DNA topoisomerase 3 [Eubacterium limosum KIST612]
2
MSQNKTLVLAEKPSVGKDIARVLKCKNGQNGYLENDRYIVTWALGHLVSLADPEAYGEKYQNWNMESLPMLPEHMKLTVLKGSGKQYKIVSSLLGRSEVKDIVIATDAGREGELVARWILDKAHCHKPIRRLWISSVTDKAISEGFKNLKPGTEFNNLYRAAQCRAEGDWLVGLNITRALTVKYNAQLSAGRVQSATLNMIVEREEAIKNFKPKPYYNILAKTPQFTLTWQGQHGKNINSKETAEKILQKMKGKSAVIKDISKKPKKSTSPGLYDLTELQRDANRLFGMSPKETLNIMQRLYESHKILTYPRTDSKYLTQDIVPTLSERLKTISIGPYKAAVSEILKLGIHTNKSFVDDRKVSDHHAIIPTEQRVILANLSTDERKIYDLVIKRFLSVFLPPYEYLQTTVTADIAGEALTAKGREIITLGYKKVYENQSEEDDDEDNEDQQLPSLKKGNALAVSQISLKELETKPPARFTEATLLSAMENPQKVVKVDAKAAKTLGETGGIGTVATRADIIEKLYKMFVIEKKGNSLYPTSKGKQLIDLVPADLKSPLMTAKWERQLELISKGKSDPEAFIADIKTYTTELVNDVKNSNEKFVHDNKSGQKCPECGKNLLEVKGKYGMMLVCQDRTCGYRENVSKNTNVRCPECHVKLEIRGKGDGALYFCKRCGFREKVSSFNKKHFDGNRKNSKREAQNYMRKMKKENQEAVNNPFAEALAKLKESE
(552) DNA topoisomerase 1 [Butyrivibrio proteoclasticus B316]
1
MASKTTTTKKNSLLIVESPTKVKAIKKFLGNGYDVAASNGHVRDLPKSQMGVDVEHDFEPKYITIRGKGDVLADLRKKVKKADHVYLATDPDREGEAISWHLIAALKLDEADAKIQRVTFNEITKNAVKEAMKHPRDIDMNLVDAQQARRVLDRMVGYSISPLLWSKIKRGLSAGRVQSVALRIIADREEEIESFIPSEYWTLDVNLAAEGEKKPLVAHYYGTGNDKKEIKSKEELDKICASLKGAKYVVSDVKKGERNKKAPLPFTTSTLQQEASKALNFSTQKTMRVAQQLYEGIELGKQGTVGLITYLRTDSTRVSDEAVAAANAYISSNFGDKYLSEGTTAKKSDAKIQDAHEAIRPTYVENTPVVVKEFLSRDQFRLYQLIWRRFMASRMAPAKYETTSVKIDAGEHRFTVAASKTVFDGFLNVYTDEDDQIEKNVLMKNLDINTKLSFDSFDSAQHFTQPAPHYTEASLVHDLEALGIGRPSTYAPTISTILARHYITKENKAIFITELGQAVNKMMNDAFPQIVDVNFTSNMEALLDGIADGNVKWKTVVENFYPDLNEAVEAAEKEMEKIQVQDEVTDEICPNCGRNMVIKYGPHGKFLACPGFPECKNTMPYFEKIGVECPKCGKDLVLKRTRKGRIYYGCIGSPECDFMSWARPVKEKCPKCGKYMVAKSNKLACSDQECGFSCNKDELKKE
(294) DNA topoisomerase [Butyrivibrio proteoclasticus B316]
7
MAKKLIITEKPSVARDFARVLNVSGNNNGYIENDQYVISWCFGHLVEMVYPEEYDPKYKKWRLEDLPFLPAKYKYGVIKNSADQYKLINNLLHREDIDTVYWAGDSGKEGQTIEENIRNYGGVRDGMTELRVWIDSMTDEEVRRGIAQARPMSDYALLGESGIMRAIEDYSLGINFSRALSVKYGKLINDAAATKSYTAIAIGRVMTCVLGMVVRREREIRNFEKTPFFRIVGSFSDAKILAEWKAVSGSAYFESPLLYKENGFKKEDSAKALIDSFNGKEAVIDSIETGNSKKRAPLLYNLTELQADCTKRFKISPSQTLEIAQELYEKKLTTYPRTDARVLTTAVAKEIYKNVKGLSAVNEVSGFVDHVLKNGLYKGIEKSPYTDDSKVTDHYAIIPTGQTSAMGSLSPLAMNVYLLICRRFVSIFYPSAEYKTAKLQIAVGNEKFFAAAKVLVSPGYLEVAGIPKDKKAEDKKGDEEGNSSEDEEDVGISKEEFLKFVENAHKGDRISVNDYMIKEGATAPPKRYTSGDLVIAMENAGNLIEDEELRETIKKKGIGTAATRAAIIQKLIDNKYLAQSKSQIITPEKLGEMIYEVVYLSVPTLLNPEMTASWEKGLEGIYNGSVNGQDYRAKLEEYIRRETGKLIEKDLTTEIVGRINQFTGKESKGLASRKPIGIKCPVCGGEITTTSFGYGCSNYFNDQIKCTFSVGRIAGKDLDEETVKTLITEGKTGVIEGFVGKNKSSFSASLRLGKDENGKYAISFNFDDVPTVYVDNMNCPACGGRIIRTVNGYSCENRGKEEGGCYFYLGEVAGKKLTEEQVRTILSGEETEVIRGFKSKNNKPFNAKLVMKTSENGKKEITFDFEGVEPDYLADVVCPDCGGRIIKKTVGFGCENFKADDPQSCKFFIGKIAQKQISEANVIELLKEGRTGTIRGFKSKDKKPFDACLVMKKNENGVSEISFDFENVEAKTVKGVTCPLCGGDIVKTPFGYGCSNYKKDDPENSCKFNIGAIAGKNLKDAQIKELLLTGETTKISGFKSKSGKPFEAKLALDKGEDGKVKGIRFVFESEDEVMEDAKCPICGKQIIKGHLGYRCEDYKKGDEGCSFFIGKIAGVMIDKENFKKLVNEKITDKIAGFTSKKGTSFDAKLAFDEKFNVVFNFDN
(712) DNA topoisomerase 1 [Roseburia hominis A2-183]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVVASNGHVRDLPKSQMGIDVEHDYEPKYITIRGKGDILAKLRKEVKKADKVYLATDPDREGEAISWHLSQALKLDGKNVRRISFNEITQNAVKASLKQPRDIDMNLVNAQQTRRILDRIVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWTLDAKLKADGEKKPLTAKFHGDENGKLAITCREEADRIMDEIRGERFEVLEVKKGERVKKAPLPFTTSTLQQEASKTLNFPISKTMRIAQQLYEGVDVKGQGTVGLITYLRTDSVRISDEADADARAYIAQNYGEEFVATQTVTQKGGAKIQDAHEAIRPSDIARTPAVVKESLSRDQFRLYQLIWKRFAASRMASAVYETTNVKIGAGKYRFGVAASKVSFEGFMSVYTSEDDEKDTNNVLLKGIDEDTKLTLDTFDEKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTITTLLGRRYIVKEAKNLYVTELGEVVNQIMKESFPSIVDEHFTANMESLLDSIGEGAVNWKTVVRNFYPDLEAAVEVAEKELQKVKIEDEVTDVVCDQCGRNMVVKYGPHGKFLACPGFPECRNTKPYLEKIGVPCPKCGKDVVLRKTKKGRKYFGCENNPECDFMSWSRPVAEKCPKCGGYMVVKGNKIACADAGCGYTRDRKADEDTK
(610) DNA topoisomerase III [Roseburia hominis A2-183]
7
MAQHKLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGEMIFRSVYELAGCKKPMKRLWISSMEDSAIRKGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPIPFYTVALELPGLTVSGERMADKAAAEQLKEACQGVNVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVANAMPFRKGIAITCDPQTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLMCAVAQPHIYSETVVIAACAGGEFTTKGKTVKHPGWKALEDAYRAKMKDTEPKKEGVEKALPELTEGQTLSVSAAIVKEGKSSLPQHFTEDTLLSAMETAGKDDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKNRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIERGQLAPEEFLDGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQNDSCKFAIWKNNKWWAAKKKQPTKAVVSALLNDGCVRVTGLYSEKTGKTYDAAVVLEDDGQYANFKLEFDQRKGGSR
(1268) DNA topoisomerase [Roseburia hominis A2-183]
7
MQLVVTEKPSVAQAISHVIGAKERKDGYMEGNGFLVSWCVGHLVELAQPEMYSEAWKKWSYESLPMIPEQWQHEVKKETATQYKILKNLMHDTRVESVVCATDAGREGELIFRLVYEQAGCRKPMKRLWISSMEESAIRDGFENLKPGSDYDSLYQSALCRQQADWLVGLNGTRLFTVLYGGKVLKVGRVQTPTLAMLVDREVKIMNFEKEQYYMAHILMDGIDAMTERIDDKARAESIAAACESQSGVVRSVIKENKSVAPPKLYDLTTLQRDANRIFGFTAKQTLEYTQSLYEKKLVTYPRTDSQYLSDDMEETAKAVIGAVYQAILFEEQTGAEPDIKRVLNSKKVTDHHAIIPTIEITKTDLSAVPEGEMKILSLVANRLLCATGKKQLYETVKAEFSCGGYSFHVSGKTVLQNGWKEFEAALKRTYRVEKTDEDKEEKKLPELSEGMTFPVIQTKVTEHFTQPPKHFTEDSLLSAMERAGAEDMGDEVERKGLGTPATRADIIEKLVKDGFVKREKKQMLPTEDGMKLITVLPDMVKSPKLTADWENTLTLVEKGEYTMQEFMDGIEDMVRELVQTYHSISDDQKSLFGTMQEVLGKCPKCGSDVVKGKFGAYCKQKCGMNVGRAMGATFSDTQMKSLLEGKKTLVRGLKGKKGSYDAYLIPEGIEDYSYIKDGKEIKGSQYKFKMEFPPRKSK
(10) DNA topoisomerase [Roseburia hominis A2-183]
7
MAKSLIITEKPSVAQEFARILGVSGRNDGYIENDGYVITWCVGHLVEMVYPEEYDERYKKWRLEDLPFLPRDYKYNVIPSVSRQYDVVHKMLHREDIDTVYWAGDAGKEGQTIEENIRKFGGVREGMKELRVWIDSQTEEEILRGIREAKDMSEYDNLAKSGVMRTIEDYAMGINFSRAMSVKYGKLLNDAAGTSSYTAIAVGRVMTCVLGMVVIREREIRNFTETPFYRVVGTFHPEGEEECRITAEWKAIEGSKYFESPLLYKENGFKKEESAQTLIAELKGQEALIDSVETGTQKKRAPLLFNLAELQAECSKRFKISPDETLQVAQDLYEKKLTTYPRTDARVLSSAVAKEITKNISRLKNFAPVAPYVERIMKEGRCRNIANTQYTDDSKITDHYAIIPTGQLTELESLNSLERSVYEMIVRRFLSIFYPPAEYQTVKLVVAAGGEKLYTSAKQLKVPGYLEIAGIPKSAKERNAAKTDGEEQTQGGDAEAAQEEEENAGLLAYADKLQKGETLFSDGYVIREGKTSPPKRYTSGSMVLAMENAGQLIEEEELREQIKGSGIGTSATRAEIIKKLVRVGYLNLNKKTQVLTPERLGEMIFEVVSMTVPALLNPKMTASWEKGLDGITRGAVVMEDYRSKLEDFIRRETVAMIEQDLTGQIATRIHPLVGKGGKGLAAKRSLGIPCPVCGGTIETTPFGYGCSNYQKDGGGCRFSIGTIAGRDLNDEEVKELLTEGHTGVLSGFVSKSKKKFSASLILEKDDEGKVSVGFDFSKNQPEILEGVVCPVCGSAVEITPFGYSCVKHHEHPDECYFSVGKIAGKALGVDDLTELLTTGKTGLIRGFTARNKKKFNACLKLEQTEDGRKNIAFDFSQNDAAVVPDVVCPICGGAIVETSFGFGCANYRQDDPDSCRFAIGTMAGKDLNAAQVKELLNQGRTGTIRGFKSKSGKKFDACVALEHTEDGRIELRFDFEHVEAKKIKDVVCPICGGDIVATPFGFGCANYVKDDPNSCRFSVGKMAEKALTEANVKELLTNGRTGTIRGFKSKSGKKFDARVALAKDEKGKVTGLKFDFTDLEAPKVKDVKCPVCGGDIVKTMFGYGCANYSKENPDSCRFAIGKIAGVSLKEAQVKELLLRGKTDVIKGFVAKTGMKFDAPLKLTPEGQIAFDFPEKPKPVETTLACPKCGKMLKKSQWYYECECGFKVSHTVAKVALTEEVMRELLETGKTKDKVTGFVSKAGNTFDTCLKLEDDRIVFDFDNPGTKREGASDGKGGERMFYEELEENAQPQPLAAEDGAQYIEEDVPPFYDAMAEEYAAYEEEEAKQQAAASNFLDEFPG
(965) DNA topoisomerase 1 [Thermincola potens JR]
1
MSKVLVIVESPAKAKTIGKFLGSRYRVKASMGHIRDLPKSQVGVDVEHDFAPKYITIRGKGEILKDLKQAAQKSSKVLLAPDPDREGEAIAWHLMHYLDINEKDKCRIEFNEITKDAIVNAIKEPRTIDRHRVDAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEIKAFVPEEYWDITGVFTGTDKKWTIEAKLLQKGKEKIHIGSEAEAQAILDDLKDASFLLTKLRKKEKKRNPVAPFITSSLQQEAYRKLNFPARKTMQVAQQLYEGLDLGPEGTVGLVTYIRTDSTRVAETAQAEAREYIKGKFGTGYVPEKARQFTTKGKIQNAHEAIRPTSVFREPDQIKNFLSRDQYKLYKLIWERFVSSQMSPAVLDTTSIDIEAGDYTFRAHGSIIKFPGYMKIYTEGKDEDDNEEEKTLPENLEEGLRLIAKSLVPKQHFTQPPPRYTDATLIKALEEHGIGRPSTYAPIVETIQKRGYVVKEQKQFHPTELGMVVVELLKEHFTDIIDIQFTAAMEEKLDLIEEGDMDWVQVLKDFYLPFKDTLERAEKVIGQVELEDEVTEEICELCGRNMVVKMGRYGKFLACPGFPACRNTKPLLEETGVKCPHCDGRLVLRRSKKGRKFYGCSNYPDCDFVTWDLPTEKKCPKCESMLVQKKFKNKGAVYQCISENCNYKEKAETITI
(1039) DNA topoisomerase 1 [Desulfotomaculum carboxydivorans CO-1-SRB]
1
MGCTNLSKTLVIVESPAKAKSIGKYLGRNYTVKASMGHLRDLPKSQFGVDVESNFSPKYIAIRGKGEIIKELRAAVKKADRILLASDPDREGEAIAWHLSKLLDIDENSNCRIEFNEITKQAIQQAVKHPRPIDIDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLIVDREEEIKAFIPEEYWSLTAKFSKTAKSTFEAKLYKYQNKKITIPNQEAMDKILADLKGVSYVVASVTRKEKLRNPAPPFTTSSLQQEASRKLNFTARKTMAVAQQLYEGLELGKEGPVGLVTYIRTDSTRVSETAVEEAKKFILERFGPAYVPKESRQTVAKGKVQDAHEAIRPTSVERDPETIKEFLTNDQYKLYKLIWSRFLASQMAAAVMDTTSMDIEGGDYLFRATGSIVKFPGFMQVYIEENDDGTKEEEKLLPELAQGDKVEAKSLTPKQHFTQPPPRYTDATLVKVLEEKGIGRPSTYAPIVETIQKRGYVVRENKQFYPTELGIIVVDLLKNYFPDIINIEFTAEMEEKLDQIAEGDQDWVNVLKDFYGPFQQTLATAEEKIGKVQVADEVTDEICEQCGKNMVIKMGRFGKFLACPGFPDCRNTKPLLEPTGVACPRCEGELVLRRSKKGRKFYGCSRYPECDFVTWDVPTNEKCPHCGDLMVEKSSRGKEKILQCVNENCPSNAGVKETKAGQKTKQTTSNK
(320) DNA topoisomerase 1 [Thermaerobacter marianensis DSM 12885]
1
MPKTLIIVESPAKAKTIKKFVGRDYTVEASMGHVRDLPKSQLGVDVDDHFTPHYITIRGKGKLIERLRQQARQADRVLLATDPDREGEAISWHLCQLLEIPQDSPCRIVFHEITRDAVRRALKEPRPIEENLVDAQQARRVLDRLVGYKLSPLLWRKVRRGLSAGRVQSVAVRLIVDREEEIEAFTPQEYWTLEADLQRRAGGEVFTARYHGDAEGKKDLPNRDAVDRLLADLEGRSFTVLGVERKERRRNPAPPFTTSTLQQEASRKLGFSVRRTMRIAQELYEGIELRGEGAVGLVTYIRTDSTRIADQALDEAAAYIAERFGPEFSAPRKQAGRRQAQAQDAHEAIRPTSVAREPDAIKDDLTPDQYKLYRLIWERFVASQMAPAILDTVTVEIGAGPHRFRATGSTVKFPGFMQLYVEGRDEGTEGEGDEGEGMLPELAEGDALDVRALRPEQHFTQPPPRYTEAMLVRALEEKGIGRPSTYAPIIETIQERGYVVKEDRRFRPTELGRVVTALLKEHFPDIVDVEFTARMEADLDRIEEGERNWEDVVRDFYGPFSETLSRAERQIQRVTLPVEETDEICEKCGRRMVIKHGRYGRFLACPGFPECRNTKPLVEKTGARCPRCGGEMVQRRSRKGRVFYGCSNYPECDFTTWDRPTAETCPECGTFLVEKRSRQGVRLVCANPQCNYEREAAGETAGAGAGSGRR
(773) DNA topoisomerase 1 [Sulfobacillus acidophilus TPY]
1
MESPAKAKTISRFLGSRYQVKASMGHVRDLPKSQFGVDLERGFEPRYITIRGKGPLLKELKDAAKKTDRVYLATDPDREGEAISWHLAESLGIPLAEARRIEFHEITKDAVTEAIRHARPIDMHLVDAQQARRVLDRVVGYQLSPLLWRKVRPGLSAGRVQSAALRLLVDREDQIQAFQPEEYYTVTLTLDTQPVMTAQYAGPLGEKGRLSPVDAQTVVGRVKKGQTVHVESVKTRERRRFPALPFTTSTLQQEASRRLGFSVKRTMSIAQQLYEGLDVQGEGTVGLVTYIRTDSTRVADVAEAEARQFIESQYGTAYWKGLGAAKRPEKERPGVQGAHEAIRPTSVMRHPDRLKASLTRDQLRLYRLIWERFVASQMAPLVYDATTVELSVGEDRFRAHGAVVKFAGFTVLYQESAADDTKAANEDDAGQGPLPVVQEGQTLTATAVEAEQHFTEPPPRFTEASLVKTLEELGIGRPSTYAPIIDTLLQREYVQREQKRLIPTPLGRLVVELLQKYFPEIVDISFTANVENQLDRVESAELGWREVLTDFYRPFAEELAKAEQDLEKVAIPVEETDEVCDQCGRPMVVKYGRFGKFLACSGYPECTATKPFVEKTGAVCPKCGDQLVVRRTRKGRTFYGCHSYPACDFVTWLRPTEKTCPRCGSSMALRKKGRQETLTCLKEGCGYEEQAQ
(9) DNA topoisomerase 1 [Desulfotomaculum kuznetsovii DSM 6115]
1
MSKTLVIVESPAKAKSIGKLLGKKYTIKASMGHVRDLPKSQFGVDVEHGFTPKYITIRGKGEIIKELRTAVKKADRVLLASDPDREGEAIAWHLANVLEIDENAPCRIEFNEITKQAVQNAVKAPRPIDYNRVNAQQARRILDRLVGYKLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEINAFVPEEYWTLTAVFTRRGKDPFEAKLYKIGDKKAEIKNQAQIEEILKELKGVSYRVVKITRREKTRQPAPPFTTSSLQQEAYRKLNFTARKTMMVAQQLYEGLELGKEGPVGLVTYIRTDSTRVAVQAQMDARAYIQEKFGPGYVPEKPRQVAARGRAQDAHEAIRPTAVEREPEAIKQYLTPDQYKLYKLIWSRFVASQMSPAIIETTSIDITGGHYTFRAAGSVVKFPGFTRVYVESRDDETKEEEGVLPALSEGEALEVKSLTPKQHFTQPPPRYTDATLVKALEEKGIGRPSTYAPILETIIKRGYVVREKKQLVPTELGMVVVDLLKKHFPDIIDVEFTAQMEESLDRIEEGEMDWVRVIQDFYGPFQETLARAEEEIGQVTVSDEVSEEICEQCGRNMVVKMGRYGKFLACPGFPECRNTRPLLEPTGVPCPQCKGELVVRRSKKGRKFYGCSRYPDCDFVVWDEPSGEKCPRCGGILVIKKGRGEQEELECVNEQCRYRVDREKKAGSNGEAARDVAAGSKLVEEKPSFDSWHNDALLPLMRAKSGRTATRGTGGRS
(679) DNA topoisomerase [Desulfotomaculum kuznetsovii DSM 6115]
7
MRKLVIAEKPSVARDIASALGKFAQKDGYLENDRLVISWALGHLLELADAHEYDPAFVKWTLEPLPIIPEEFKLHPIRSGAKQLKILKQLLNSADVAEVINACDAGREGELIFRRIYEWCGCRKPVKRLWLSEATPSAIREAFKKLRDGRELDNLAAAARARAEADWIVGINATRAFSVKHKTLLSVGRVQTPTLALVVQREREIRDFKPETYWEVRATFQKSGGATYRGRWFRGGESRIKEKSRAEELVRAALAAGSGRVAQVEKRTKTEAPPLLFNLNDLQKEANRKYGMTAQKVLDAAQALYEKHKLITYPRTDSRHLTEALARDTLQKRLAALEKCPEYGELIRRIRPGMLPGKRYIDDAGVTDHHAIIPTDVTPDPSALNPAERQVYDLVVRRFLAMFYPPAVYDETAVVTEVGDETFISRGRVEIEPGWKAVYGPEEKEEKDGKDEDGESQPLPPLAEGETVGVEEAGAVERQTKPPKRYTEATLLAAMENAGRLLDDREMAETLKAAGGIGTPATRAAIIETLIKRGYIERRKKTLVPTPRGEALIDLVPEKLKSVELTAQWEDGLRRIEEGLDDARLWLVGLKNFTVEVVAMAKEQEANGAVHQKEVMGRCPLCGRDVLEYTKSYGCSGYRDGCNFAIWKETAGKKITAKQARELLQKGRTGVIKGFKSKAGKSFDAILTLGEDGKVNFEFADHAGQALGKCPLCGKDVIEGKKGYGCAGWKEGCKFVIWKEIAGKKIAANLAKELLQKGRTGVIKGFKSRAGKDFEAALVLGEGGKIEFEFKNRQEG
(398) DNA topoisomerase 1 [Syntrophobotulus glycolicus DSM 8271]
1
MPKTLVIVESPAKAKSISKFLSKNYQVKASMGHLRDLPKSQMGVNIEHDFEPKYIPIRGRGDLIKELKAAAKTADQVLLASDPDREGEAIAWHLMHLLGINQEKSSRVEFHEITKPTIQKAIKNPRKIDLHKVDAQQARRVLDRLVGYKLSPLLWKKIKKGLSAGRVQSVAVRLICDREEEIKVFESQEYWTLLAQFLCPGGNFSAKLIHKAGKRIEIKSRQEVDEIIVQLRRAVCVISDVKNREKKKQPSPPFTTSSLQQEAYRKLNFAPKRTMMLAQQLYEGIDLGKEGTVGLITYMRTDSVRISELAQDEAKEYILASFGSDFYPGRQNYTSKRRTQEAHEAIRPTSVLRTPDSAKEFLSRDQLRLYRLIWDRFLASQMSAAVYDTLTVDVAADKYTLRANASTVKFPGYLSVYEESTDETEEKQDGDDRCLKVNVTPGQKVELAEIKEKQHFTEPPPRYTEASLVKKMEEEGIGRPSTYAPTIDTVQTRGYVVKEERKLVPTELGEIVVSLLKEHFKDIVDLEFTANMEEKLDNIEEGQTQWKSVIRDFYIPFEETLNKAEAIIGKIKVEDQESDVLCEFCGRRMVIKMGRFGKFLACPGFPDCKNAKPLLEEVGVNCPQCGEKLVVRRSKKGRKFYGCSNYPECNFISWEKPAPVNCPDCNSLMTEKTIKQKVNYVCTNKDCRHTEEKVEEKKE
(1311) DNA topoisomerase 3 [Syntrophobotulus glycolicus DSM 8271]
2
MGKSLVIAEKPSVGREIAKMLSCHKKDQGYFTGPKYLVTWALGHLVTLADPEKYDQRYKTWKMDDLPMLPEQMELVVIKETSKQFSVIKNLMKMPDLDELIIATDAGREGELVARWIIKKAGWRKPIKRLWISSQTERAIKEGFAALKPAKEYDHLYASAECRAQADWLIGLNVTRALTCKFSAQLSAGRVQTPTLAMVVEREKQIKSFVPKEFWTIQAFTKGFSMTWHDKTNGQSRIFDQSKADQMIKKISGHDAEITEIKKESKKELPPLAYDLTELQRDANRKYGFSAKTTSSVMQQLYEYHKIVTYPRTDSRYITEDIVSTLPERLNSIAVGPYAQFAAKILKNKITTTKRFVDQSKVSDHHAIIPTEQPVHLQKLSNEEYKIYDLIVKRFLAVLSKPFEYEQTTVKADIRGELFEVKGKIVKQNGWKEVYQGTGNWEEEQEDEEREQTLPDLHKGERIPILEVKTKAGKTKPPARYTEATLLTAMEHPGKNIENEKLREAVKQTGGLGTPATRAEIIEKLFSSFYLERNGKEIFPTSKGLQLIELVPVDLKSAELTAKWEQQLSEISKGKVKSTEFLNGIRSYARQLVSTVSENNQVFRHDNLTRNKCPECGKFLLQVKGKKGELLICQDRECGYRKGLSVSSNARCPNCHKKMDLKGEGENRIFTCTCGYREKLASFTQRKSENPGKVNKKDVQKYLNKQEDNGMINDALAQALAKLKK
(995) DNA topoisomerase 1 [Lactobacillus plantarum WCFS1]
1
MAASTTKAKPAAKRKTATKTATKRKSKTPAKKLVIVESPSKAKTIEKYLGRSYKVVASLGHIRDLPKSKMGVDVDNDYEPHYISIRGKGDVIKGLRKEAKKAKAVYLASDPDREGEAIAWHLSYLLGLDPKDKNRVVFNEITKDTVKNAFKEPRSIDMDLVDAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSIALDLIIQRENEIKAFKPQEYWTIDSEFQKGRSKFMASFYGTHGKKQPLDDNDAVQKILGQLDRNGDFNVVKVVKKERKRFPAPPFTTSTMQQDANRKLNFRTRKTMMAAQQLYEGINVGGKEGSVGLITYMRTDSTRISSIAKHEASQFLHKEYGAEYAATKPVKGKLPEGAQDAHEAIRPSSVFRTPASIKDYLTKDQFRLYQLIWSRFVASQMTPEVLDTMAVTIDQNDVQFRANGSKTKFAGFTKIYDKTEKNNVLPDLSEGDVVKLSKTDPQQHFTQPPARYSEANLIKALEENGVGRPSTYAPTLDTIQRRYYVKLEARRFVPTELGEIVNDIIQEYFPDVVNVGFTASLEEQLDATEEGKENWVKVVDSFYKPFSKEVATAEESMEKIQIKDELAGFNCDICGAPMVVKMGRYGKFFACSRFPDCRNTKPIVKEIGVVCPQCKKGQVIERKSKKNRIFYGCSRFPDCDFVSWDKPVGRDCPKDGHYLVEKKVKGGKQVLCPNGDYTENVQK
(1615) DNA topoisomerase 1 [Lactobacillus rhamnosus ATCC 8530]
1
MADKKLVIVESPAKAKTIEKYLGRTYKVVASLGHIRDLPKSQMGVDVENNYEPKYISIRGKGDVIKSLKKDAKKASRVYLAADPDREGEAIAWHVSHILGLDPNAKNRVVFNEITKDAVKNAFKTPRGIDMDLVDAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKNFIPEEYWSLDAEFQKGRSKKFSASFYGIKNKKMALKNNEAVQKVLSQIDKAKPFSVTNVVKKERKRFPAPPFTTSTLQQEANRKLGFRTRKTMMLAQQLYEGINLGGKLGTVGLITYMRTDSTRVSNVAKTETSHYLHEKYGEAYAAVKIRQGKLQEGAQDAHEAIRPTSTLRTPESLASVLDKDQMKLYRLIWSRFVASEMTPAIIDTVAVTLNQNDVTFRANGSQMKFEGFTKLYVSSRDSGEKDNVLPPLAVGDAVKMLKTDPAQHFTQPPARYSEANLVKALEENGVGRPSTYAPTIETIQKRYYVKLNARRFEPTELGEIVNSLIVEFFPDIVNIKFTANVESELDSIETGEANWVKVIDQFYKPFEKEVAHAETGIEKIQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKAIVKEIGVICPKCHKGQVVERKSKRNRVFYGCSRYPDCDFVSWDKPVGRDCPVCGHFLVEKKSKAGTQVVCPNNDYKEALQKA
(116) DNA topoisomerase 3 [butyrate-producing bacterium SM4/1]
2
MKSLVIAEKPSVGKDIARVLGCRKSADGCLEGDKYIVTWAFGHLVELAAPEEYDKKYKDWNMADLPMMPEPFKLEVIGKTAKQFGVVKRQLFRNDVKDIVIATDAGREGELVARFILMKAGCRKPLKRLWISSVTDRAIKEGFSRLRDGREYNHLRDAAMCRAEADWLVGLNATRALTCKYNAQLSCGRVQTPTLAIIAKREEEIRNFRPKAYWGLTARTSKPALTLTWQDKKSGGMRSFDRDRMEGLQKSLRDQQVWITKVKKTPKKTMAPLLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDVADTIHDRLAACGTGPYRKLAGKLSKNVWTKKASFINDGKVTDHHAIIPTEQFVQLQNMTSEERKIYDLVVRRFLAVLYPAAEYDETVITAEIGGEIFTARGKVMRTPGWREVYESADESGLSGTGGYLDEEDGDEDGEGPQNERVKAQTLPDLREGDVIGPAGISLTEGKTKPPAPFNEATLLSAMENPVRYMESGDRAMAKTLGETGGLGTVATRADIIEKLFSGFMLEKKGKDICLTSKAKQLLRLVPEDLRKPELTAQWEMRLSKIAKGEMKRDAFMEDIRTYTKDIVEEIKGGEGTFRHDNLTNTKCPRCGKRMLSVKGKNSQMLVCQDRECGYRETISRTSNARCPKCHKKMELRGKGENQMFSCVCGYKEKLSNFKERRQREGAGVTKRDVARYLNQQKKEEKMVNNPFADALKKMQEQDV
(1040) DNA topoisomerase 1 [Clostridiales genomosp. BVAB3 str. UPII9-5]
1
MDKTLVIVESPAKAKTIGRYLGKDYEIAASVGHIRDLPSSTMGVDINNDFKPRYINMRGKEKIINDLKAKAAANAHTLIATDPDREGEAIAWHLANVLHIDPLSLCRITFNEITKNTVKTAVEQPRAIDLDLVNAQQARRILDRLVGYELSPLLWSKVKKGLSAGRVQSVATLMLVEREEAIRSFEPQEYWLLSVHLAEEKQPLADFTAQFYGRLDASGKCVKEELPDASAVENIKKQIQEPYKVLEIVKRNRQRNPAPPYTTSTLQQDAARKLGFSAKKTMLIAQQLYEGVDLPELGATALVTYIRTDSVRSSADAVAGMRKIIVSTFGPEFVPAEPNHFKNKNAAQDAHEAIRPSHLELPPEKIKVGLSTEQYKLYRLIWERFLASQMTPAKLAATTINIAAGDIIFRVTGETVIFPGFLKVNPEKVAEKEMNILPDLEKNETLRKLELLEEQKFTQPPARYNEASLIKAMEEAGIGRPSTYAPTLSTIMERQYAVKENKSLIPTELGFLVTNILREHFKKLINIKFTAEMENDLDEVESGKLNWVELIKNFYPVFHAAIVKAQKDISKIVIPVEATGEKCPECGADLVIKEGRFGKFIACSAFPNCKFTKNAVEKVDGHCPRCGSDLVSRRSRRGSIFYVCSQNADDKNCDFISWDLPVDNEKCPECGSYMVWHRLRGRLYKRCSNDSCVTRKSKRGKTDKNVAGEKQANDTAEPSAVETKRRKNTPKEKKKDND
(1074) DNA topoisomerase [Clostridium kluyveri DSM 555]
3
MKLILAEKPSLALNIVKSIGNMNRNDGYFENRDYLITFAYGHLLRLYDVDNYFKRGKTKWNLDELPFVPEDFKFKIREDKGVKKQYEVIKNLIRRNDVTEIVNCGDADREGEVIVNNIISRIFKEENINKPVKRLWLPEQTTQTIRQELRNLKDNRDYKNLYNEGLARTYLDWTYGINLTRYLSIKSQTFLPVGRVLIPIVKFIYDRDRAIENFKPETYFEIGAVIKKDNLEIKAKLKDRRFSADEREKAANLLNSLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKQFKMSLDDTLKHLQKLYECGFTTYPRTNTEYLAENEKGKIKSIIEVMKEKFNVDIDFKDKKKIFDNNKVESHSAITPTTKIPEIEKLSEDEKKVYTAIRNRFISNFLNEETIIEETYVIIRIVDEVIELKGNVIKQTGFLKYENIKKENELPDFVEDEKLDTKLSVDEKQTQKPNRVTESELNNFLKNPFKKKEIQDLENTNDDEEYKMILEGCEIGTVATRAVIIKNAQKYEYIKEVKGHFECENKGIRLIDVLKRLNIDLDKGKTVEFGKQLKGVYKNDIEINTIIYNVKSELNNIIRKGDEIKIDRIESKKYESMGVCPICGKGNIMANKFGYGCSRWREGCKFFIGKQIAGKNISESMAKKLIKNKKTNVIKGFKSKNGKSFDAVLTIKDENVAFDFSSESKGLGTCPVCGKGNVIANKSGYGCDKWKEGCKFFIGSKIASKSITESMVKKLLKDKKTNLIKGFKSKNGEVFDAFLIIKDSKIVFDFKE
(878) DNA topoisomerase 3 [Clostridium kluyveri DSM 555]
2
MSKILVLAEKPSVGRDLAKVLHCNKKNLGYIEGDKYVVTWALGHLVTLADPEDYDERYKSWVLEDLPMLPDKLKLVVIKQSGKQFNIVKSQMNRKDIGEIIIATDSGREGELVARWIIEKARVKKTVKRLWISSQTDKAIKEGFANLKNSSKYDNLYKAARCRAEADWVVGLNITRALTCKYNAQLTAGRVQSATLAMIVNREEEIKNFKAKDYFVINAKTKEFTLMWRDKNNNSNIYEENRVNKILAITKGKAANIIDVRESYKKQYAPALYDLTELQRDANRIFGYSAKHTLSIMQRLYENYKILTYPRTDSRYISTDIVDTLKERLKAISVGSYKIYASELLKTRINAHKGFVDNSKVSDHHAIIPTEEVLTLSLLSSEEKNIYDLVVKRFLAVMLPPFEYVQTSIITDINGENFIARGKVVKSKGWKKVYDIGNQVIEDDENENQILPELKKGDSIDIISIESRRLKTKPPARFNEGTLLSAMEKPQKYISIDKLYAKTLGETGGIGTVATRADIIEKLFNMFYVEKNGKDIIPTSKGKQLIELVPEDLKSPLLTAQWEMDLELISKGKKDPEVFIRKMREYAGTLVEDVKESSNKFKHDNITGKKCPVCGKYMLEVKGKQGRMLVCQDRECGHRENLARLTNARCPECHKKLELKGEGEKRIYVCSHCSFREKFSSFNKRFKENEGKLNKKEVSKYMKKMNGENKANINSSLAEALANIKFK
(1525) DNA topoisomerase 1 [Deinococcus geothermalis DSM 11300]
8
MPRTLVIVESPAKAKTIEKYLGKGYAVESSIGHIRDLPRSAADIPEKYRGKAWARLGLDVEDDFRPLYIVAPEKRQHVARLKKLAAEADEIILATDDDREGESIAWHLYQELKPKVPVKRMVFHEITREAIEQAIKHPRQIDTNLVEAQEARRALDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRMLVERERERMRFVSGTWWDLLVTARTAGGATFPARLTDVGGQRLATGKDFDPLTGQLRRGAEVRLLDEAAAHALAEGLKAQPLTVTSAEEKPFTQRPYPPFITSTLQQEGSRKLGFAATRTMRAAQRLYEGGYITYMRTDSTNLSSEAVNAARAQVKAMYGEAYLSPQPRLYVKKAKNAQEAHEAIRPAGSSFRTPESLRGELSGDEWRLYDLIWKRTVASQMADARGRSLRVRLAGTTQAGETVGLGAAGRTLDFPGFLRAYVEGSDDPTAALEDRETPLPPLSEGERVTAESVKAESHETQPPARYTEASLVQALEAAGIGRPSTYASILGTIQDRGYAVKKGQALVPTWTAFATSALLEHHFGQLVDYDFTARMEEDLDDIAGGRARRVPYLRRFYLGEGGEGMALRPLIESKMGEIDARGIATIHVPKLEGTGIEVRVGRYGPYMQRGEQKANLPDDLAPDELTAEKAEELLGRPTGDRVLGTDPATGQPVLARAGRYGPYVTLGEGNPPLRSASLFPGDDLNSITLERALRLLSLPRLVGVSEGEEIWAMNGKFGPYLRRGNDSRSLAHHEQLFTVTLPEAEALFRQPRFRARGTAAAPLKTFEYEGRAPILLKSGRYGPYLTDGERNATLRKGEDETNLTAERALEILEERGKAPQQKAGQKTARAASARGAKSGKTATKAAKKTATQVSTGKKAVSRRPTAQAAPKATFTWADLKPHLGVLSEPERRLVTAIREQGRRVEDVAPTLGLDVKKAKGMVLQASKKLHQAARGA
(19) DNA topoisomerase 1 [Deinococcus maricopensis DSM 21211]
1
MSTLVIVESPSKAKKIQAYLGAGYTVRASLGHIRDLPASKADIPARYAAEPWARLGIHVQDSFRPLYVISRGKAKVVRELRELARGANRVLLATDPDREGEAIAWHLMVALGLKGSVERMTFHEITREAIQAAARATRPLDYALVGAQEARRTLDRLVGYGVSPTLWTAVGPKLSAGRVQSAALAALAAREHARMAFVPADYWRVTARVGAGRPFTAVVLSVNGQRLATPKDFDAGTGQLAADALLMTPEQADRLVAFLRARDATVTGVERAPYTSRPPAPFTTSTLQQEASKALKFSPKHSMDVAQRLYENGFITYMRTDSPALSDEALQAAREAATALFSEGSVPARPRTYAARGANAQEAHEAIRPAGRSFRAPDDTPLTGDERALYDLIYRRTVASQMTDLTGTRTVMHLKVGAVALGATGRVVHDPGFTRLYQDASEGDGDETQALPDAEVGAVLPVRDAAAEERKTPAPGRFTEASLVRALERAGVGRPSTYASILSTLDARGYTRVVRRQLTVTWVGLLVSAYLAGSFADLVDAGFTASMEADLDRIAGGALTREAYLTRFWSEGLAGTIGRAGRAAPVLTVPRVPGATVTVQDGTPLLRLHGRSAPLPADLVPDDLTPDVAEQVLNGERKAAQRASGGKRARSGGARTSRARSSRKAARPK
(1710) DNA topoisomerase 1 [Deinococcus maricopensis DSM 21211]
8
MPKTLVIVESPAKAKTIEKYLGKGYVVESSIGHIRDLPRSAAEIPERFKSQAWARLGLNPDEDFRALYVVAPEKRAHVAKLKKLAADADEVVLATDDDREGESIAWHLLQELKPKVPVRRMVFHEITKEAILKAIQSPRTIDEHLVEAQEARRALDRLYGYEVSPVLWRKVAPKLSAGRVQSVATRMLVERERERMRFVSATWWDIEARLTTQASERFPANLLEVDGVRLAGGKDFDALTGQLKRGANVLLLNEADATALAAALTGQPYRVLSAEEKPFTQRPYPPFITSTLQQEGGRKLGFSASRTMRAAQRLYEQGFITYMRTDSTNLSAEATEAARDQARKLYGPAFVPAAPRVYAKKAKNAQEAHEAIRPAGASFRTPDSVRGELGGSSDEWRLYDLIWKRTVASQMSDARGRRLQVRLEGRSGDGRTALLGANGRTIDFPGFLRAYVEGSDDPEAQLGDREVTLPPLNPGDTVNGDAFKAAGHATQPPARYTEASLVQALEAAGIGRPSTYASILTTIQDRGYAMKKGQALVPTWTAFATSALLEGHFGRLVDYDFTARMEEDLDDIAGGRQQRAPYLRGFYYGEGGGLGLKGLIASNMEAIDPRVVATIEIPKLAGSGIELRVGRYGPYLARGEQKANLPDDLAPDELTFEKAEELFNRPSGERPLGADPDTGLTVVARAGRFGPYVTLGEENPPVKTASLFPGDDLTTINLDRALELLSLPRLVGESEGEEVWALNGKFGPYLKRGNDSRSLANHDQLFTVTLDEAEELFRQPRYGAKRAAAGPLKRYEYADRSAIELRSGRFGPYLTDGERNATLRRDETPESLTDADARSILEERGKEPKKKPGKAPAKAKAKPAAKPTKAAGSNAKPKAGTAKPAAKNAARKATAKAAAASPAWADLRAHLGVLGEQERTLVTATRDAGRKVEDVAPELGLDIKKAKGMALQASKKLNQAYRAAQGDA
(1521) DNA topoisomerase [Veillonella parvula DSM 2008]
3
MRLFIAEKPSMAREISKCLPENKNIQKRNGYFIQGDDVVTWVVGHVLHQAEPGDYDDKYIRWRPQDLPIVPAEWKLLVTDSSRQQFEIVKDLIDKADVIVNAGDPDREGQLLVDEVLYYVGNTKPVQRILLNALDEKSIRSALDDLRDNKDFHNLYQSALARARADWLIGMNLSRAYTLSERYKGNKVTLPIGRVKTPTLALVVRRERELAAFKPVDYFTVKVLYNHPNGVFWATWQPTDEQKGLDPDGRLINKAIADSLVEQLQSGPDGVIKAVTKSKKKDVQRLPLSLSSLQVLAGKAFSYDPQTVLDTAQKLYEKKLTTYPRSDCEYLPPNQYDDRNAILNNLQNAGDERLAQWAADADRSIKSRAWNEKKITAHHAIIPTTVACNINSLSQEERNIYFLISQAYIAQFYGEHIYEQTKIVVEQCKEEFVANGRVVIEEGWKLLYKRHKSKSTTDNDEPDLTDERGAESDPKKEIIEETDHLPAVKKNDTVLYTDSSVEAKQTKPPSRFTPSTLLQAMKEIHKFVKNEDLKKQLKAVSGIGTEATRANIIDELISRGFMKTSGKKQVLSPTETGYLLVDALPEELLYPDETAVWEERLALMSEGEDTLDSFLADQIKFLKLLIDKLGFDKVINSDQMMPNVVRTITSQNRKRPMDSESVDLSSLPVCPKCKKGRLQQRNGKFGAFLGCTNYPTCKHTQPVEGDTSSVEGNIEVSDEDKQYKCPRCNVGYFVKQEVRGRTNWICSNRSQCKTQCSDVDGVPSIYVNKSNIT
(1689) DNA topoisomerase 1 [Veillonella parvula DSM 2008]
1
MSIKRSIVIGEPKAASTSKDTKKKNTKKESTTIKRKVAKESLTPMGIVRDKSVLQTSVPPEQREPRVYNPDGKVLVIVESPAKSKTIEKFLGPNYVVKASMGHLRDLPKSQIGIDIEHDFTPRYSNLVTRKKVIDELVSYADESSAVLLATDPDREGEAISWHLAYILNVDPTSTCRITFNEITKNAVAEALDSPRTIDMNMVDAQQARRVLDRIVGYKLSPLLWKKVCKGLSAGRVQSVAVRLICEREREIQAFVPQEYWTIEGNFETPKKEAFIAELTHIKGEKIDITTESDAQAIVDAIGNEDAVVTNIEKRKRSRKAVPPFTTSTLQQDGVRKLNFGAKRTMMIAQHLYEGLEIGSYGHVGLITYMRTDSTRISKEMQAMAKDFILRNYGEDYYPSKPNVYGSKGSAQDAHEAIRPTSLELTPKMVEPFLSRDELKLYTLIWNRFMASQMAPQQNESTTIELNVKNDYTFKATGSRVIFPGFSAVYEDAKKEDVPQLPALKKNYAAHTVEVLPEQHFTQPPPRYSEASLIKTLEELGIGRPSTYAPILDTIVSRNYVENTNKQFVPTELGFVVVDFLITYFEKIINTGFTRDLEEELDAIASGKDTYVKVLSDFYEVFAQELEDASDVDRIEIASMESDEICELCNSPMVYKFGRYGKFLACSNFPECKNTKPITVGTGVTCPKCKEGEIVERKSRRGRIFYGCNRYPQCDFTLWDKPTHDFCETCGSIMVEKTYKNGTVKKFCSNETCPTRPPKKTRKKKSEASEEPVKESKKSSKAKKEETTIES
(194) DNA topoisomerase III [Oscillibacter valericigenes Sjm18-20]
7
MKLVIAEKPSVAQSIAAVLGAKQRGGGYLEGSGWLVSWCFGHLAELASAESYNPEYAKWKYDDLPIVPETWRFKVSRDKWQQFDILKKLMHSEDVSEVVNACDAGREGELIFRTAYCLAGCSKPMKRLWISSMEDSAIRDGFAHLRPGSDYDGLHQSALCRSKADWLVGINATRLFSVLYHRTLNVGRVMSPTLALIVQREAEIDAFRAEPFYTVELDVGFPAVSEKFREESQAKAVAAACQGQPAAVKSVERKEKSEKAPALYDLTTLQRNANRLLGYTAQQTLDYLQSLYEKKLCTYPRTDARFLTDDMEGSVPALVSVAATLYEAAAPGKIGAAQICDSKNVSDHHALVPTVSAGKAALSALPAGERKILRLVSRQLLCAVSEACRYAETVAAVECGGSVFTAKGRTVLAPGWKNYIQQEQPEKPLPDLTDGQALTVSGISTKEGKMTPPKHYTEDTLLSAMEVAGAKETPDDAERKGLGTPATRAAILEKLVSTGFVERKKAKKTVSLMPSHTGVSLITVLPEQLQSPLLTAEWEQKLKQVERGELTADAFLDGITAMLRELVKTYKAIKGAEVLFPSGREVVGKCPRCGGDVTESKKGFFCESADCRFGLWRDNKFLTAKRAVLDKKAVTALLKTGRVAMTGLYSEKTGKTYDATLVLEDDGQRANFKLEFNHG
(689) DNA topoisomerase 1 [Oscillibacter valericigenes Sjm18-20]
1
MAKQSLVIVESPAKAKTIEKYLGKEFRVKASMGHLRDLPKSTLGVDVEHDFDPVYQPIKGKEDIISDLKKSAKAADTVYLATDPDREGEAISWHLKQLLNLPDSKTHRVTFNEITKKVVQESIQEPRDIDQNLVDAQQARRILDRIVGYQLSPLLWKKIRRGLSAGRVQSVATRMVDDREREIEAFKPEEYWTLDAVFRGDDAKKTEFTAHYHGRDGKKVELKSAEEVEAVVEETRNQAFAVSAVKRTDKQRSPSPPFTTSTLQQDASRKLSMTPRRTMAIAQQLYEGVDIAGEGTVGLITYMRTDSLRISEEALSAAKSFILGRYGKDYYPARTRHYKAKANAQDAHEAIRPSNVALTPEQVKGDLTGEQYRLYKLIWSRFLASQMENAVYDSVSVDIAAGEHMFRATASGLKFAGYTAVYEEGKDEEKEEKESPLPALREGEPLALKEFYRDQHFTQPPAHYTDATLIRAMEEQGIGRPSTYAPTVSTIIDREYVIKEGKYLKITNLGRVVTELMKQRFSDIADLQFTAHMEQKLDSVEEGVTPWKNVLRDFYGDFEKNLKDAETALEGTRIKVPDEVSEEICPECGRNLVVKSGRFGRFLACPGYPDCSFTMPLVVVMPGRCPKCGGRLMKRTGVSKKTGKQYNYYCCEHRTARDEAAKCDFMTWDVPVKDDCPVCGQTMFKRSGRGYKRPYCVNPNCSNFLPEDQRGYPKKKTDEGGESAGSAEAAEESATDVTAAKKATAKKPAAKAKSKRTAKEPAAKKSAAGSGADKKTGVTKTAARKPAAKKTAAKKTVAKKSAAEKEN
(1185) DNA topoisomerase 1 [Deinococcus deserti VCD115]
8
MARTLVIVESPAKARTIEKYLGKGYAVESSIGHIRDLPKSASDIPEKYKGKAWARLGLDIENDFQPLYVVAPDKRQHVAKLRKLAADADEIILATDDDREGESIAWHLFQELKPKVPVKRMVFHEITKEAIQAAIAHPRQIDTNLVEAQEARRALDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRMLVERERERMRFVSATWWDLLVTGKTGDGQTFPARLTDVGGQRLAAGKDFDPLTGRLKEGAAVRLLTEAEAQALTAGLTGQALTVTSAEEKPFTQRPYAPFITSTLQQEGSRKLGFAATRTMRAAQKLYEGGYITYMRTDSTNLSVEAVTAARTQVTQMYGPAFLHPQPRVYAKKAKNAQEAHEAIRPAGSSFRTPDSLRGELGGDEWRLYDLIWKRTVASQMADARGRSLRVRLGGQAQGGETVGLSASGRTIDFPGFLRAYVEGSDDPNAALEDRDTPLPPLKEGQQVTAETVRPESHETQPPARYTEASLVQALEAAGIGRPSTYASILGTIQDRGYATKKGQALVPTWTAFATSALLEHHFGKLVDYDFTARMEEDLDDIAGGRASRVPYLRRFYLGDEGQGMALKPLIDRQMGEIDARGIATIHVPKLDGTGIEVRVGRYGPYMQRGEDKANLPEGLVPDELTAEVAEDLMSRPSGDRVIGTDEASGHPVVARAGRYGPYVTLGDSNPPVRSASLFPGDDLNTLTMERALRLLSLPRLVGVSEGEEVWAMNGKYGPYLKRGGDSRSLNSHEELFTVGLHEAEALFMQPRFRARGVAAAPLRTFEFEGRPPILLKSGRFGPYLTDGERNATLRKGEDEDNLTPERALEILEERGKEPKKKAGKSPSRKASVKPAAGKSAKAGSSTKKPAAKKPAAKKAGAKGPASKSSAAKTPLTWAELKPHLGVLSEQERELVTATREQGRKVDEVAPGLGLDVKKAKGMALQASKKLNQAARGE
(361) DNA topoisomerase 1 [Lactobacillus crispatus ST1]
1
MPTKAKSKTTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDDYKPKYISIRGKGDTIKELKSEAKKAKDVYLASDPDREGEAIAWHVAHALNLDEKAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWSIDAEFAKGKETFKSAFYGVDGKKKELPNIDSVKDVLAKIDKKKDFVVDKVVARQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRTSPVAQQEASKFLHENYGAEFAAKSQRHFKNQEDAQDAHEAIRPTSVYRTPESLKSVLTTEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVIFRTTGSKLKFAGFTKVYDNQQEKNVDLPDLEEGDKVKMTKSDNKQHFTLPPARYTEASLVHALEENGVGRPSTYAPTIDTIQRRYYVKLDGRSIVPTELGEIVDGLIESFFPDITDVDYTARLENELDEVEDGKKDWVHVVDEYYQPFKKELNKADSEIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIIKEIGVVCPKCGKGQVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKHSKKGPVILCPNGDYREDSENEKNN
(1776) DNA topoisomerase 1 [Caldicellulosiruptor bescii DSM 6725]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINKLKKYAQEAEKVYLATDPDREGEAISWHLATILGLDTNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRILDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDVQEFKAKFYGDKKGKIELKNQDHVQKIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRVSEEAQQAARSLIVQKFGKEYLPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSVYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEALKPIKLESKQHFTQPPSRYTEATLIKALEENGIGRPSTYAPTIQTILERGYVAKEDRFLKPTELGRIVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVKKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPVKNCPKCGSLMFEKGKKGNKKLVCSNENCAYQEKTGEKGE
(1030) Reverse gyrase [Caldicellulosiruptor bescii DSM 6725]
6
MATGAKYYHSCINCSGINTDTRNEKGLPCEKCLKDDHLTENVFELLKGRGLLKDYQIYWNFHQNYKMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTVSLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEEFEKRFISCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAVLKSSKNIDTLLQMIGFSEDEIEKATERLRSKNRENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLDNSIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFSIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEILQTEKLRQLVSKYISKEDYSKIVNKIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKVSRKIQNDDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALRNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLDVPRIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGNEGAHEAIRPVKPISPEELKELAYEKYTQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFKINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSLTDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLLELYNDISVLLNN
(1340) DNA topoisomerase 1 [Caldicellulosiruptor kristjanssonii I77R1B]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEILKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGNLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(946) Reverse gyrase [Caldicellulosiruptor kristjanssonii I77R1B]
6
MATGAKYYHSCINCGGINTDIRNENGLPCEQCLSQEQINDIYESLKKMGTLKDYRLYWNFQQNFDMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANAVKILLFNSSMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFLIDMDKAPRFVLERVFVEYLDNHPKLKGYFKSVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWVEENGVDFKNLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLDFLPMQIYPLFENKDYGITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLQELYNDISALVND
(1306) DNA topoisomerase 1 [Caldicellulosiruptor obsidiansis OB47]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAEAAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATKLVVEKEEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQIQEIEEKIKNKEFKVVKLKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARKLIAQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMNPESIKDSLTPEQYKLYKLIYDRFLASQMESSIYDVLSAELEVEGYVFRLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEISEGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKIEWTEVVRKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKKVIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPKCGSLMFEKGRKGNKKLVCSNENCLYEEKMGEKGE
(1675) Reverse gyrase [Caldicellulosiruptor obsidiansis OB47]
6
MATGAKYYHSCINCGGINTDTRNENGLPCEQCLSQKQINDIYKSLKKMGTLKDYQLYWNFQQNLNAFKMFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANTVKILLFNSLMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRTKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLAENGIKIGTTWSNFDEEFELFKEEKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPRFRFSVDMDKAPRFVLERVFVEYLEDHPKLKEYFKNVEILQTEKLRQLVLKYISAESYNKIVQEIFSHLKITDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKESRKIQNNDFYQIDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIEDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNINLVKSQIVRRIEDRWVGFELSSKLQENFQSYNLSAGRVQSTILGWIVEREKEYAKSERTFTMLKLENGYNLEIEGEEECKRVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKEFFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIRVYQLIFNRFMSSQMKNPKVLFQKVCFKIADKEIVKDIPVKIEEEGWLHFLSMQIYPLFENKDYSVTDRRSYKKHTIQLYTQSSLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILQELYNDISELLNK
(1140) DNA topoisomerase 1 [Candidatus Cloacimonas acidaminovorans str. Evry]
1
MSKGLIIVESPAKAGTISKFLKNQFSVKASMGHIRDLPKRELGVNVHQGFKPVYIIDKTKSKVIAELKEATLSADSVYLASDNDREGEAIAWHLSETLKKELNNKPVYRIVFNEITSQAINEAIKNPGQIDMAKVEAQQARRILDRLVGYEISPLLWKVITKDLSAGRVQSVALRLICEREAEIKAFVPKEYWKIEADFWKDNLPPFKAVLEKIEGKKVEIPDEKSAIEIVENSQNAEAILSEIKRSNRNVEPLPPFITSTLQQEASKILGFQAQKTMSIAQVLYEGIDLGGERTGLITYMRTDSTRMAEEAITKAQNLIKERFGKELVHPKVRVFKNKQSAQDAHEAIRPTDPFRTPESVAQYLTKEQMKLYTLIWQRFIATQMIPVKLLSTSVKINAGKAEFVSSGAQIMEEGFLKAYPHLYIPLGEKIHQDYAKNDVLEHSPLEKTQHFTTSPARYTEASLIKELEAKGIGRPSTYATIIETLRKRKYVTMEKKAFLPTQLGSDVNRFLVDKFDYLFNVQFTAEMETKLDEVEYSNIAWNEVVQEYYDQLVALIRQVDVKKEKNNFVQDTGIVCDVCKQGTMLIKHSKRGDFLSCSRFPQCKNTKNFTRDEDGNIKIFVPTPLNENCPQCGSPLMLRTGKYGEFIACSNYPKCKYARPKTLGIKCPECGIGELTARKSKKGRTFYSCNRYPECKYITNDKPLPISCPKCGNPYIVEKYSREKGKIKICPNCKTEME
(1403) DNA topoisomerase 1 [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
1
MLKLPKKSEKNKLVIVESPAKAKTIEKILGSSYKVISSYGHIIDLPKTKIGVDVNNDFKPSYNTIKGKGEVIKQLKEASKKADKIYLASDPDREGESIAWHIANTLKLDHNEKNRIEFHEITEKAIKDAVKNPRKINIARVNSQQARRILDRLVGYEISPFLWKLISPNTSAGRVQSVALKIICELEDKIKAFVPEKYWDVKGIFDTKYSLNLYKIDNKKIDKLKDEKLLDRVKKDLKKKYEVISSKVSKKTKNPPLPLKTSTLQQLASSYLGFSASKTMMVAQKLYEGISIKGEHKGLITYMRTDSTRISEEAKEMARNYITKNFGKEYLGSATPKAKKESKNVQDAHEGIRPTDINYTPENIMEFLDKDQFKLYNLIWQRFLISQLAAMKYEQFEYILEKDKIEYRGTINKIIFDGYYKVFKEDEDLPIGDFPEIKEGDKFTLDKLDIKEDYTKPPARLTESSLVKTLEAEGIGRPSTYASIIDTLKKREYVELQNKSFVPTEIGYEVKTQLDKFFPNIMNIKFTAKLEDELDEVDSGDKNWIDLLKVFYTELQKYEEKCKVVVEEELEKLVESDVIAKNGKPMIMKIGRFGRYLASQDTESKENISLKGIDISLEDIKKGKIFVKKQIEELGKKKEGQKTDIILDNGSRLLLKYGRFGAYLESENYKEDNIRKTIPKEIKTKIEKNTIKKENDILYLKDIFDKIEKEEAEILKKAGKCEKCGRPFKISNGRWGKFLACTGYPECKNIKKIEKK
(1733) DNA topoisomerase 1 [Candidatus Methylomirabilis oxyfera]
1
MPKSLVVVESPAKAKTIEKYLGKGFVVTASMGHVRDLPAKSLSIDIAHDFAPQYEIIAGREKVMSALRKAAKTADAIYLAADPDREGEAICWHLQQELDAAKKPVHRVTFDEITKRAVREAFDHPSTIDQRLVDAQQARRILDRLVGYQISPLLWDKVKRGLSAGRVQSVALRLIADREREIKAFVKTEYWSVDVALEGRTPPSLRAGLYKIDGGRVSLPDQAQTDQVVRELREQEFRITDLTRKEKRRNPVPPFTTSKLQQEAVRKLRFTARRAMQIAQQLYEGIEVGEEGAVGLITYMRTDSVRVSQEAQAEAARYIAERFGQPFVPDRPPAYRSGRGAQEAHEAIRPTSVYRDPVSLRQFLTKDQLALYTLIWSRFVASQMPPALYDVTTVTIQGGRFTLRAGGRHQRFAGFMQVYIEGRDEAPETKPTEAKDETAEETAVEEEAELTLPPLEVGDPLRLLDVTPAQHFTQPPPRFTEATLVKELEERGIGRPSTYAAILSVIQNRDYVVKAQGKFRPTELGGIVVDLLVESFPRVMDYEFTARMETTLDEIEEGQKNWLEEMRRFYEPFSQWVKEAAVGMRNIKAMEEKTEEICERCGSGMVIRWGRFGRFLACTNYPECKGTRELTAELKGEHGTDEDTDVSAEAVTAPCENCGRPMVMKRGRFGPFLGCSGYPECKTIRKLSQAEAASARPAPQPTDEVCEKCGSPMVLREGRFGRFLSCSTYPTCKHIKPIAIGVKCPQCGSPLSERRTKRGRVFYGCTAYPKCAFAIWDRPIQEPCPQCGAAFLVEKKLKGGGVSIRCHAEGCAYAREADTTVQANA
(404) DNA topoisomerase 1 [Marinithermus hydrothermalis DSM 14884]
1
MPGKTLVVVESPAKAKTIARILGDGYEVKASKGHVADLPERTLGVDLEADFAPTYEIKKDKRPVVEALRKAARGAERVILATDPDREGEAISWHVARLLDLDPSAPVRVHFHEITPRVVREAIAHPAPINQNLVDAQQARRVLDRLVGYNLSPLLSEKFRQRALSAGRVQSVALRLIVEREEEIEAFEPQEYWTVSGAFTAGAPFTAELYSIDGQRVVDKNRSRFLLTSEAETARILEAIRRVPEWRVAEVARKTRRKSPPPPFTTSTLQQAASSRLGWTASRTMRVAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEALEAVRRFIPEAFGPAYLPQTPNRFKSKKSGVQDAHEAIRPTAVERTPERVKPHLSEEEYRLYTLIWQRFVASQMSPAVYDQTVVTVEGGAYRFRATGSVLRFDGYLRAWGREEDEAEQLLPEIPEGAPAQLTDLTPAQHFTQPPPRYNDASLVKTMEELGIGRPSTYAPTIETLERRRYIERQGRALRPTPLGREVVAFLKAHFPRVVAYEFTAEMENRLDAVEEGKVPWPKVVREFFEPFTKELEKVPRKTCPLCGRPLELKVSRYGQFLGCTGYPECRYTEPLEKREAEPLGEPCPECGRELVRKHGRYGTFIACSGYPECTYTRDEAPSTGLTCPKCREGEVVVKTSRKGKPYYRCNRKACDFLSFYPLVEERCDTCGWNLMEKGRAKTRVCSNPACPRYGGPDLSKPRPSRKSRATRRAAKPKPAPAPKATWTDLEPFLSRLAEDEARLARLVEGEGRSLKDAAQALGLTEEAAAALYKRAIFKLRMAYGRARKAGEGSVPEEVT
(1251) DNA topoisomerase III [Akkermansia muciniphila ATCC BAA-835]
7
MSKTLIIAEKPSVATDLARVLGKELGKFTRDKSGAFYQNDRAIITSAVGHLLEQKKPMTEEGKSLPWKFDYLPVIPRKFELEPIKQSEDRLKKVLQLARSKDVTEIVNACDAGREGELIFHNLARYGKWTKPTRRLWMQSMTDEAILNAWHGMRSEADMKPLTNAAVCRSESDWLVGLNSTRALTILQSRGGFNVTPAGRVQTPTLAILTQRELEIQAFEPEPYSEVWAEFDVQSGSYSGRWIDRDWKKNDHPHSRAERIWDPEQAAVIRDRCRGKAGTVTEEKKPVTTVAPLLYDLTSLQREAANRYGFSAKRTLQLAQECYEKHKVLTYPRTDSRYLPEDYLGKVYGIVGTVAEQNPEFAPFARDILDNKRIKPNRRVFDTKKVSDHFAIIPTGKMEKLTGDAQKLFEMVMARFLAVFFPAAVFEDTRRTTLITHQDGVTDAFLTTGRVLVEPGWQAVYGRKAGTSSKEELVPVRDGEQAALREIEIRNAMTKPPARYNEATLLAAMEGAGKLVHDEELAAAMSERGLGTPATRASIIEGLISQEYIVRDGRELLATRRGIELIALLERIGLKTLTSPSLTGEWEYKLKQMEQAALPRDSFMEGIKTLTGEIVKRVKDFREAQQQVELPEMELDCPSCHAHGLKNTLDAVSCRSCKFSIRKVISGRDMADEELKTLIVDGRTGILHGFTSRFGKPFEAGLELNDKFRATLYFPAREEDEAAGVEEAVKVASVAIPDMGEHDVMETAKAWKIPSLTLGKEHAAVSVSRTILGREIPLDQVLKILAEGKSDLMKGFISQRTKRPFDAYLVFNAKTGKIGFEFPPRERKYPAKNAAGKTEGKAEKTGRNAAKTAGKDSKSGGAAKKGRKQ
(807) DNA topoisomerase 1 [Oceanithermus profundus DSM 14977]
1
MSGKTLVVVESPAKAKTIKKILGPNYEVKASVGHVADLPQRDLGVDLEHDFEPKYVVKKEKQKVVSDLKKAAGKAERVLLATDPDREGEAISWHVARLLDLDPQKPLRVHFHEITPRVIKEAVKKPTPIDQNLVDAQQARRVLDRLVGYNLSPVLSAQFRQRALSAGRVQSVALRLVTEREAEIEAFVPKEYWTLTGTFDAGARFAAELYEIDGKRVLDKKKENFLITSEAQARAVEAEVRAVPAWQVAAVERKEKRRHALPPFTTSTLQQAASSRLGWGAGRTMRVAQRLYEGVNLGPEGPVGLITYMRTDSVRIAPEAIAEARAFIPEQYGPDYLPPKPNYYRGKKQGVQDAHEAIRPTSVQRRPEQVKPFLSDEEFKLYDLIWRRFVASQMTPAVYDQTAITVEGGKFTFRAAGSILKFDGFLRVWGRDQQEEQPLPEVDAGAPARLVELASEQHFTQPPPRYTDASLVKKMEELGIGRPSTYAPTIDTLERRAYVERQGRALKPTELGKRVIGFLVEHFPRVVAYEFTAQVEDRLDEVEEGKQAWPAVVREFYEPFTEELSRVPRKTCPVCGRPLEIKVSRYGQFLGCTGYPECTYTEPLEEKKEAEPIGEDCPKCGAPLVRKWGRYGSFIACSAYPKCDYTRDEAPSTGITCPKCKEGEIVQKTSRRGKPYWRCNKQGCDFLVFDPPTEQTCPKCGWIMVKKGKREVLKCSNPDCEDYAYPNFKNRPPRGKAGGGRKKTRKKGAAKKKAGPKATWADLEPFTAGLEEAERRLVVQVEGEGVPLEQAAANLGVTAEEAAKLHKRAMFKLRMAYGRAKIKPR
(731) DNA topoisomerase 1 [Meiothermus ruber DSM 1279]
1
MPDSTLIVVESPAKAKSIQKMLGAGYEVRASKGHIADLPEHELGVDTQADFAPQYTVKKDKQPIVEELKRAARGKRVLIATDPDREGEAIGWHVARLLGLNPQTPLRVEFHEITPKVVRAAVQKPRPIDQSLVDAQQARRVLDRLVGYQLSPVLSMEFRRRALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLEGRFESEGQQFKAMLYSLGSERVQSGDKFLITSEKQAQEIARLAKDVSGYRIGSIERRERRRNAPPPFITSTLQQAASSRLGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDSTRVSQEALAEVRAFIPRHFGPAYLPEKPNFFAGKKAANAQDAHEAIRPTSTERTPDALRKHLSDEEYRLYQLIWQRFVASQMTPAVFDQTTVTVVGASGTPSGDLIFRAVGSVLKFDGYLRVYGREEGDEAENRLPPLQENASARLLEVTPEQHFTEPPPRYTDASLVKTLEEMGIGRPSTYAPTIDTLERRGYLERSGKSLKPTPLGREVTGYLIKSFPDVVAYDFTAQLESRLDEIEEGKAAWPKVVREFYEPFLKDFAKVPQKLCPKCGRPLELKVSRFGQFLGCTGYPECKHTERLELKKEPEPIGEACPACGEGQLVRRHGRYGSFISCSRYPECKYTRDEAPSTGIECPKCHAGEVVQKTSKRGKPYYRCNNPACDFLSFDPLLPDKCPLCGWNEVAKGRSGKRACTNPGCERYGGPKLEALNQRRTKSSSKTSGTAKNKVKDRAKASATWADLEPFITKAGLTPEQAEVARRTQGQQKQVAAVAKALNQPEEAVLKLFRQAMFKLRMEYGKARKEAVSA
(732) DNA topoisomerase 1 [Meiothermus ruber DSM 1279]
1
MPDSTLIVVESPAKAKSIQKMLGAGYEVRASKGHIADLPEHELGVDTQADFAPQYTVKKDKQPIVEELKRAARGKRVLIATDPDREGEAIGWHVARLLGLNPQTPLRVEFHEITPKVVRAAVQKPRPIDQSLVDAQQARRVLDRLVGYQLSPVLSMEFRRRALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLEGRFESEGQQFKAMLYSLGSERVQSGDKFLITSEKQAQEIARLAKDVSGYRIGSIERRERRRNAPPPFITSTLQQAASSRLGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDSTRVSQEALAEVRAFIPRHFGPAYLPEKPNFFAGKKAANAQDAHEAIRPTSTERTPDALRKHLSDEEYRLYQLIWQRFVASQMTPAVFDQTTVTVVGASGTPSGDLIFRAVGSVLKFDGYLRVYGREEGDEAENRLPPLQENASARLLEVTPEQHFTEPPPRYTDASLVKTLEEMGIGRPSTYAPTIDTLERRGYLERSGKSLKPTPLGREVTGYLIKSFPDVVAYDFTAQLESRLDEIEEGKAAWPKVVREFYEPFLKDFAKVPQKLCPKCGRPLELKVSRFGQFLGCTGYPECKHTERLELKKEPEPIGEACPACGEGQLVRRHGRYGSFISCSRYPECKYTRDEAPSTGIECPKCHAGEVVQKTSKRGKPYYRCNNPACDFLSFDPLLPDKCPLCGWNEVAKGRSGKRACTNPGCERYGGPKLEALNQRRTKSSSKTSGTAKNKVKDRAKASATWADLEPFITKAGLTPEQAEVARRTQGQQKQVAAVAKALNQPEEAVLKLFRQAMFKLRMEYGKARKEAVSA
(1775) DNA topoisomerase 1 [Chlamydophila pneumoniae LPCoLN]
1
MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDKQEVINHIRKLAAKCEKVYLSPDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEALKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEKARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYEGVDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDAHEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQITPAIYDTLAVQITTDTEIDLRASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDVLIKEEVSQEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHKGKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAEDTPWDSPCPLCGGVMKVRHGRYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSEYPECSVIGNSIDAVITKYSGTEKIPYKKKTPIKKKSSAKTTKAAKAPSKKGKAKSSVKKSSEKKTGPLFLPSPDLAKMIGNEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATIIGPNPIDMFQLSKHLSQHLTKVSNDESSASS
(1247) DNA topoisomerase 1 [Chlamydia psittaci 6BC]
1
MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKEFGIDIEHDFEPDYQVLPDKQEVISQICKLASSCDIVYLSPDPDREGEAIAWHIANQLPENTHIQRISFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNVRVFLQDPKTSKTFWAHLYSADGKKWEKELPKGKTEDEILLINSETQAQHYVDLLEDASYRVTRVEAKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNNVRDYIHNTFGQEYLPKSPNVYTTKKMTQDAHEAIRPTDIHLSPDKLEGKLSDDQLKLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKLDDDTTEEENLSLPQLHAQDVLDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVITDIECSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVDTPWNSPCPVCGGEMKVRHGRFGTFLGCFNYPQCRGTISIHKKGEEVEQEEAIPCPAIGCSGKILKKRSRYNKTFYSCSEYPDCSVIGNTIDAVITKYTGTAKTPYEKKTTGKKKATTKSSSKTTKTTAKKKKSEGKTPKTPKAGALLTPSPQLALMIGPEPVGRGEATKKVWQYIKDHNLQSPENKKMLLPDEKFEAIIGPEPVDMFQLPKLLNQHLFKSD
(1246) DNA topoisomerase 1 [Chlamydia psittaci 6BC]
1
MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKEFGIDIEHDFEPDYQVLPDKQEVISQICKLASSCDIVYLSPDPDREGEAIAWHIANQLPENTHIQRISFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNVRVFLQDPKTSKTFWAHLYSADGKKWEKELPKGKTEDEILLINSETQAQHYVDLLEDASYRVTRVEAKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNNVRDYIHNTFGQEYLPKSPNVYTTKKMTQDAHEAIRPTDIHLSPDKLEGKLSDDQLKLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKLDDDTTEEENLSLPQLHAQDVLDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVITDIECSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVDTPWNSPCPVCGGEMKVRHGRFGTFLGCFNYPQCRGTISIHKKGEEVEQEEAIPCPAIGCSGKILKKRSRYNKTFYSCSEYPDCSVIGNTIDAVITKYTGTAKTPYEKKTTGKKKATTKSSSKTTKTTAKKKKSEGKTPKTPKAGALLTPSPQLALMIGPEPVGRGEATKKVWQYIKDHNLQSPENKKMLLPDEKFEAIIGPEPVDMFQLPKLLNQHLFKSD
(1153) DNA topoisomerase 1 [Chlamydia psittaci C19/98]
1
MESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKEFGIDIEHDFEPDYQVLPDKQEVISQICKLASSCDIVYLSPDPDREGEAIAWHIANQLPENTHIQRISFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNVRVFLQDPKTSKTFWAHLYSADGKKWEKELPKGKTEDEILLINSETQAQHYVDLLEDASYRVTRVEAKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNNVRDYIHNTFGQEYLPKSPNVYTTKKMTQDAHEAIRPTDIHLSPDKLEGKLSDDQLKLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKLDDDTTEEENLSLPQLHAQDVLDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVITDIECSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVDTPWNSPCPVCGGEMKVRHGRFGTFLGCFNYPQCRGTISIHKKGEEVEQEEAIPCPAIGCSGKILKKRSRYNKTFYSCSEYPDCSVIGNTIDAVITKYTGTAKTPYEKKTTGKKKATTKSSSKTTKTTAKKKKSEGKTPKTPKAGALLTPSPQLALMIGPEPVGRGEATKKVWQYIKDHNLQSPENKKMLLPDEKFEAIIGPEPVDMFQLPKLLNQHLFKSD
(1036) DNA topoisomerase 1 [Zobellia galactanivorans]
1
MAKNLVIVESPAKAKTIEKFLGKDYKVESSFGHIADLPSKELGVDVENDFKPKYIVDKDKKALVKKLGDLAKKAETIWLASDEDREGEAISWHLAETLGLDKNKTKRIVFNSITKSAIQKAIENPREINYNLVNAQQARRVLDRLVGYELSPVLWKKIKPGLSAGRVQSVAVRLIVERERDIEAFTAEASFRVSAEFKTLEGSVFTAKLNKTFPTKEEAQAFLNENIGADFSVGNLDKKPAKKSPSAPFTTSTLQQEASRKLYFSVGRTMQVAQRLYEAGLITYMRTDSVNLSGEAIAAAKDAIIDNYGEKYSTVRNFKGKSKGAQEAHEAIRPTDITNQSPSLERDQSKLYELIWKRTIASQMSDAQLERTNVKIKASTHSELFTANGEVIKFDGFLKVYMEGLDEEDVAEEQEGMLPAMKVGEALKNNYITATERFSRPPYRFTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTVEGTERNYVQLLLEAGAVKEKKLSEMVGSDKGKLVPTDIGMIVNDFLVSHFATILDYNFTAKVEEDFDEIAEGEEDWQKVMRDFYKDFHPNVLDVQENADRASGERILGEDPKTGRQVSVRLGRFGPMVQMGTVDDEEKPKFASLLPEQSLTTITYDEAMELFKLPRKLGVYEGEEIEANVGRFGPYVRFGKKFVSLEAGESAFDVNFDRAVELIKQKQKADAPIYTYEGKEVTKGTGRFGPFIKWDGMFINVNKKYDFDNLSNDDLIELIEAKKQKEIDKVVQNWPEEGIRIEKARWGRHNIIKGKVKVELAKTVDAAKMSLDEAKKMIEQKTPKKKAKAKPKAKKK
(1806) DNA topoisomerase III [Zobellia galactanivorans]
7
MKVCIAEKPSVAREIASVLGANTKHDGYYVGNGYAVTYTFGHLCTLKEPSDYKPHWKSWDLNNLPMLPEHFETKVTKDSGIQKQFKIIKQLFDKADVVINCGDAGQEGELIQRWVLNQANYKGKVERLWISSLTKEAIKEGFDNLKPSTDYDNLYYAGFSRAIGDWLLGMNATRLYTLKHGGYKQVLSVGRVQTPTLAMLVDRFKEIENFKPQPYWELQTLYRETLFSYEEGRFLKVEDGEKLANIVKEHDFEIVSISKKAGNEYAPKLFDLTGLQVYCNTKFGFSADETLKIVQKLYEQKVVTYPRVDTTFLPNDVYPKVPEILKKLTKYDTLTKPLDGKKLKKTKKVFDDSKVTDHHAIIPTGQQINLQYNQQQVYDIIVRRFIAVFYPDCKVSNTTVIGKAETVKFKTTGKEILEKGWRIVFETPNAPSKESGILPTFKKGEKGPHEPSFLEKQTKPPKQYTEASLLRAMETAGKKVDDDELRELMKENGIGRPSTRANIIETLFRRKYIKRNKKQVIPTVTGIQLIDTIQNEMLKSAELTGKWEKQLKDIEKGTFSAGSFIKQMKKMVDQLVYDVRSETRKANISAVNNKPPAAASKKKAIKKATDITSEVCPKCKKGSIRRGKSAYGCSEFNKTCDFVIPFKFQGKTISEKQYVRLFQKGSTVNLKGFKVNNDSVEGLVRFDDSFKLKLEPKKPKIQVKNTSEENRCPKCNKGTIIKGKTAYGCSEYKTGCDFRFSYDAIREKAKGRPLTKELVFEIFREH
(526) DNA topoisomerase 1 [Thermodesulfovibrio yellowstonii DSM 11347]
1
MELKGKNLIIVESPAKAKTINKIVGKDFQVKASIGHIKDLPEDRLGVDIEKGFQPDYIIIPGKEKIVKELKDSAKNAQKIFIATDPDREGEAIAYHIAEEIKVPENKVYRAIFHEITPNAVKAAIANPSKIDINKVYSQQARRILDRLVGYNLSPFLWKKVKKGLSAGRVQSVALRMVVEREKEILIFQPENYWTIVGNFKNDENLKELRANLYKYKGKLIIDRKEEKAKFLITDEETAQKIIEELKKLNYILTKVEKKKKKKNPPEPFRTATLQAQASSTLGFSPKKTMMLAQQLYEGIDIEGTRIGLITYMRTDSTRVAEEAKKWAKNIIEKNFGKEFVGNHKIHETKKQKTPIQDAHECIRPTYPDKSPESIKKYLTKEQYSLYKLIWDRFLASQMSPAEVEQTTYIIEDLDSIAQFRVTGSVITFPGFLIIYKDEESEEDTVLPQLNEKTSLKISELEAQKHTTEPPPRYTEATLVKALEEKGIGRPSTYATILSTIQERGYVKKVKQKLQPTYLGFVVNDLLEEKFPELMDYSFTAKMEEDLDKISLNEAKWNKVIEEFYKEFENDLDQASKISKVIKPKEIKTSFKCEKCGKDMVIRWSKGVPFLACSGYPECKNTRSLNNNENGSTKKTLDKKCPQCGAQLVVRNGKRGEFIACSNYPKCKFTQSITAQVKCPQCGGDILKKQTKKGRTFWACANYPKCKFTLSNEPVPAECPKCKSSYMLKKKDRNGTEFLICHNKACKGKIEIKEHSTGTDPAQQKDANPARSGRKQR
(1595) DNA topoisomerase 1 [Simkania negevensis Z]
1
MAKGKGKTLIIVESPTKVKTLKKFLGNDYHVESSVGHIRDLPKKGFGIDIDNDFEPVYENLPDKKEVISKLKKTAQECDTVFLSPDPDREGEAIAWHIAAILPKGPNVKRVTFNAITKDAVTEAIKHPRDIDLSLVDAQQARRLLDRMVGYKISPLLQRRIKRSGSGSLSAGRVQSVALKLVVDREKEIEAFVPVEYWNIGAILRPKPKERAFPAALYAVDGKKVEKELVKGKDFCTVSNEIEAKKITAALKHSIYTIQKVEKKEKKRHPVPPFITSTLQQEASRHYGFSAQRTMSIAQSLYEGVDLGKEGTEGLITYMRTDSVRIEPEAISAARKLIDGAYGKEYLPPKPKQYSTKKSAQDAHEAIRPTNLNHPPDVIKSSLNIDQYKLYLLIWRRFLASQMNPAIYDTVSCHIETDQKMSLRAVGSIIKFKGFLAVYEEKEDTEEDQPPQEEENLLPDLEEGKTLELIEVTSAQAFTKPPPRFTEASLVKELEKSGIGRPSTYASIMNKIHSRAYTTKERLALKPTELGKIIAQMLEAHFTMIMDIEFTAKMEDELDDIAESKKNWKEFVGGFWEKFVPVMEKAEKEAFVPKIMTDINCPKCGHKLQKIWARDKYFYGCSNYPDCKFTVPIEALEFNKDEYAEDFDWDQPCTKCSSPMQIRFSRFGAFLGCSRYPDCNGIVNIPKKGEIIPDDLPNCPAVGCDGQIKARKSRWGKTFFSCSNYPDCDVIVNEVDQLEVKYQDHPKTPYQKKTKKGGKRAGGSGRAKKLSKELQAVVGEKELTRGEVTKKIWEYIKSHNLQDPSNKRLIVPDEKLEKVFGNSEPLDMFKLAGVLGKHID
(569) DNA topoisomerase [Waddlia chondrophila WSU 86-1044]
7
MNVVVAEKPSVARDLAEHLGAASRKEGYIEGNGYKITWAFGHLVGLKKPEEYHPQWKQWSLETLPLLPKPFELTEIGDEGAKKQLGILKKLLVQANRIICATDAGREGELIFRYIMQWCNLEEKPFQRLWLNSLTPEAIKTAFEKMKAGSEYQHLFQAARCRSEADWIVGLNGTRNLTIRYGKGTLWSLGRVQTPVLAMITERDDEIAFFQSEPFWELMTTYRDAAFKYNGQRFSKKEEGEALLDTIKDALLRIEGIKKKNEKQMPPQLFDLTELQREMNKRFGISAADTLKAAQSLYESKLITYPRTDSQYLNKEMKKDVVNALRSLQPLKPEETEALDLNQLNFTKRIIDDKKVTDHHAIIPTGQNPKQIPTIQAQVFDTIHTRLLAAFYPPCLKETVVAEAVVQTLKFTAKGTVIKDPGWTKLYSKNEEKKDLLPAFVKGESGPQSPYLKEGKTQPPKSYTENSLLGAMAAAGKQVDDPKQRELLKDKGIGTPATRAAIIETLIARGYVKREKKNLKSTSSGKFLISLIQSPALKSAQLTGEWESKLKAIETGNYSSEEFMKNIEQFTKEIIKTSDVNQICEEQLGPCPKCNEPMIEGKKGFGCSAWNKGCDYVLWKEQNGIQLRKEQVQRLLQKGILLSPIGRSIYTLTRKGHVQILELE
(1229) DNA topoisomerase 1 [Waddlia chondrophila WSU 86-1044]
1
MSKSLIIVESPAKMKTLKKFLGDAYILESSVGHIRDLPEKEFGIDIENEFEPKYVTMPEKEKVINSLKKAAKNVDTVYLSPDPDREGEAIAWHIMNILPKGTVYKRISFNSITKDAVLKALQFPRDIDMALVDAQQARRLLDRIVGYKISPILNRRIQRGRDGGVSAGRVQSVALKLVVDREAEIEAFIPVEYWNLAAILKAARDSRSFKANLYSVDGQRVEKEAVEGKNFFLIPNKETADQVIERMQSGPFTVQTVVKKEKKRNPVPPFITSTLQQEASRHHGYSSAKTMNIAQSLYEGIDLGNEGAEGLITYMRTDSVRVAPEALDEVRKHIKEVYGKDFLPESAKMYTTKKAAQDAHEAIRPTNLAHTPEHVKSYLTREQYMLYKLIWQRFVASQMNPAIYDTVSADISAGSEIIIRATGSVIKFQGFLAVYEEMEDDVETAEDGKILPPLEEGMELTLLELTSDQAFTRPPPRFTEASLVKELEKSGIGRPSTYASIMNKIQGREYTIKENSRLKPTELGRVIAQMLETNFPEIMNIGFTAQMEDDLELIASNEKDWKKLIKDFWESFYPTLEEAEKNAFVPKILTDIDCPECGSKLQKVWFKSKYFYGCSSYPDCSYSAPAEEILFNKEDYAEGFNWEQKCPLCQSEMKVRHGRFGAFLGCTKYPECRGIINIPKKGEEIINPEDLPPCPATDCTGQIVARKSRFGKTFFSCSSFPDCDVIVNDLTQLQSKYVDHPRTPYVKKTKKGKRGRPTKADKEKGKKTQAKKKRNVAPSALSPELAEIVGSHEATRGDALKSVWAYIKSNKLQDPENKRVIKPDEKLGKVFGNMEPVDMFKIAGILSQHIGKKD
(1312) DNA topoisomerase 1 [Bacteroides vulgatus ATCC 8482]
1
MQKNLVIVESPAKAKTIEKFLGNDYKVLSSYGHIRDLKKKEFSIDVENGFEPTYEIPADKKKLVAELKAEAKKADMVWLASDEDREGEAISWHLFEVLGLDPEKTKRIVFHEITKTAILKAIENPRDIDVNLVNAQQARRILDRIVGFELSPVLWKKVKPALSAGRVQSVAVRLIVEREREVHAFVSEPSYRVTAVFEVPDVDGNEVEVKAELSNRFKTKEEAQAFLETCKDAQFSIEDITTRPVKKSPAAPFTTSTLQQEAARKLGFTVAQTMMVAQRLYENGQITYMRTDSVNLSDLALNTSKQTILSLMGERYVKVRKFATKTKGAQEAHEAIRPTYMENETVNGTGQEQKLYELIWKRTIASQMADAELEKTTATIVISNSSEKFIATGEVITFDGFLRVYKESYDDDNEQEDEGRLLPPLSKGEKLIRKEILATQRFTQCPPRYTEASLVRKLEELGIGRPSTYAPTISTVQQRGYVEKGNSEGVKRPYDILKLKGGKITETTKTEMTGNEKAKLLPTDTGIVVNDFLMEYFPEIMDFNFTANVEKEFDEVAEGEKEWTGMMDSFYKGFHPLVDKTIHSKTEHKVGERVLGTDPVSGKPVSVKIGRFGPVIQIGTADDEEKPRFAQLAKGLSMETITLEEALDAFKLPRTLGDYDGHTVTVGVGRFGPYVRYDKLFVSIPKGTDPMEISLDEAVELIKNKIEAQEKKFIKVFDADPDMQVLNGRYGPYISYQKKNYKIPENVEPADLSLEACFKVIELQKSKAETRKTKAASRNRGTVNMEEESEKPEESAKSKAASKVKGTAKAKK
(416) Putative DNA topoisomerase [Bacteroides vulgatus ATCC 8482]
7
MIVCIAEKPSVARDIADVLGAKTKKDGYIEGNGYQVTWTFGHLCTLKEPHEYTPSWKAWSLSSLPMIPPRFGIKLISDPGIEKQFRIIEGLMQNADEIINCGDAGQEGELIQRWVMQKAGAHCPVKRLWISSLTEEAIREGFSKLKDQKEFQPLYEAGLSRAIGDWVLGMNATRLYTLKYGQNRQILSIGRVQTPTLALIVKRQQEIENFTPQQYWVLATLYRETTFSAIIRKSDEELAQEESDAKENPKKAKKAEGNRGIPPITDLATGQALMERIKNVPFTVTEVAKKQGTEAPPRLFDLTSLQVECNKKFAYSADETLKLIQSLYEKKVTTYPRVDTTFLSDDIYPKCPNILAGLTPYTVFTAPLAGQKLIKSKKVFDNSKVTDHHAIIPTGQPPVNLTEMEKRVFDLVARRFIAVFYPDCKFATTTVIGEADSIEFKATGKQILDPGWRVIFAKPQTNLPEGMTDPDAEARENDEEHSLPAFVKGESGPHLPKLDEKWTQPPRPYTEATLLRAMETAGKLVDNDELRDALKENGIGRPSTRAAIIETLFKRHYIRKERKNLIATPTGIELVGLIREELLKSAELTGIWEKKLREIEKKSYDATTFLNELKQMVSEIVYSVLSDNTNRRVTTIEETATKTATTSTVKQPKKKAGTSRKNASSATPAPTIPSDNELVGKSCPLCGKGTIIKGKTAYGCSEWKNGCTYRKPF
(851) DNA topoisomerase [Bacteroides vulgatus ATCC 8482]
3
MIAIVTDRPNVGREIARVLGAGRKENGYMTGNGYMVTWTYGNMLSLAMPKDSGTARVEREDLPLLPPSVLTVRHVKTDTGWNPDINAVLQLKVIAKVLNACDTIIAATDASREGEMLFRHLYGFLGCKQPCLRLWISSLTDEAITEGMANLLPCDRFDNLFLAADSRNRADWLLGVNSSHAICKAVGFGNNSLGRVQTPVLAEICRRYRERENHMPADSWPVFISLCKNDRILKMRHVDDLVARREALALYEDCKAAKNARITAVRKRTEEIGAPALYNLAELQKDANRYHGLTAIQVQEIAQSLYEKRLISYPRTSSRLLPGDVYDTLPPVMEKMLSRKEFRQYAGMVDLAAPQDSIGAQDTMEHHAIIITGIQPGKLGREEMQVYTLIVGRVLETFMPPCKVEYTTVDAVCAARKFRIRTYRILEKGWLGIFEREHIVAKGCMPCPMLPEFFQEEILPVAGCSLIHKKSLPVSPYTDEELVDYMDKAGLGTVSTRTNILRTLLERKYIRYSGKYVVPTPKGLFLYETVRGMKVADASLTSGWETELARIERGELSQEEFLDGVLETVNEVTGEIFRNHPVEKRPQGTI
(1121) DNA topoisomerase I [Bacteroides vulgatus ATCC 8482]
7
MIAIVTDRPNVGREIARVLGAGRKENGYMTGNGYMVTWTYGNMLSLAMPKDSGTAHVEWKDFPLLPPSFLTVRHVKTDTGWNPDINAVLQLKVIAKVLNACDTIIAATDASREGEMLFRHLYGFLGCKQPCLRLWISSLTDEAITEGMANLLPCDRFDNLFLAADSRNRADWLLGVNSSYAICKAVSFGNNSLGRVQTPVLAEICRRYRERENFLPADSWPVFVSLCKDRQIIKLRHTEDFQEYRYASELYGDCKAVRNARIATVSRESEDIRAPAPYNLTELQKDANRYHNLTAIQVQDITQGLYEKKLISYPRTASRLLTRDVYDTLPAVMEKILSRKEFRQYAKMTDFAAPPSDISAQETTDHHAIIVTGMPPGTLNKEEQLVYTLILGRTLEAFMPSCRVEYTTIDVVCAARKFSVQTYRVLKKGWLSIFGREHLIARGGMPCSALPDFSPGEPVPVSGCNIVRKRTLPVSPYTDEELVGYMDRSGLGTVSTRTNIIRTLLERKYIRYSGKYVIPTPKGLFFYETVRGMKVADTSLTSGWEAEVARIEQGKLTQEEFLGGVLEQVKEVTGEIFRIYQAKNNP
(1091) DNA topoisomerase 1 [Candidatus Nitrospira defluvii]
1
MAKSLIIVESPTKARTITKYLGRGYSVMASVGHVKDLPTSKLGVDLDNDFEPQYVTIKGKSKVLADIKKKAQEVDTVFLAPDPDREGEAIAWHIAQELHGKGKKKDGKVYRVLFNEITESAIKRALKSPGEIDMKLVQAQQARRVLDRIVGYQGSQLLWKKVRRGLSMGRVQSVAVRLICDREKEREAFRAEEYWSIVALLAGDNPPAFEAKLHSMNGQDADIGTGERAQQILDAVQGKSFVVQSIERKEKKRNPVAPFITSRLQQEAARKLHFSPKKTMTLAQQLYEGIEIGAEGPTGLITYMRTDSPRISQEATEDARVVIRERFGVEYLPATPNVYKTQKAAQEAHEAIRPTSAARDPESIRQYLEQDQYNLYKLIWNRFIASQMVPAIMDVTRVDSSPMGTPDRYVFRTTGTVVKFAGHTAVYLEGTDKELPSHKPKNEQETDDESDRQLPALREGESLHLVAQEAQTLPGLVSKQHFTQPPPRYNEALLIRELEEKGIGRPSTYASIISTIQDRKYVEKVEGRFLPTETGRTVNDFLLKGFPDLLDTEFTSHMEEQLDEVEEGTKPWVSAVRDFYTPFVREMELAQGIPGPKDIVEPPTNLPCEKCGRMLEIKWGRNGKFLACPAYKDDPPCKNTQNFEKLPDGTIKIVPKLEETTDEKCEKCSSPMVVKSGRFGKFLACSAYPECKTTKAIALGVKCPQPGCGGDLVQKRTKKGRNFYSCSRYPQCEYALWDRPINKPCPKCQAPFLVEKVSKQAGRSVQCRNEDECGYREAG
(858) DNA topoisomerase [Bacteroides salanitronis DSM 18170]
3
MEHTLILTDKPEVGKTIARIIGADKRGNGYMAGGGYIVTWTFGNMLSLAMPKDYGKARVERKDFPLVPRPFQLMVKHVRTDNGWIPDINAVKQLKVIEKLLPECSRIIAATDASREGELLFRQLYRYLGCSLPVLRLWISSLTEQAVREGMKRMQPLEMYDGLFRAGDCRAKADWLLGMNASYALCRATGLGNHSLGRVQTPVLAAISGRYRDRENHIASDSWHIYVSTAKEGIPFKLRSVDTFHDRDRAGEFHRDCSHAGGLRITTVTRWVKELPPPALYSLGELQKDAGRYYGLTVCEVHDIAQSLYEKKLISYPRTSCRTLSPDVAAMLPDIMGKMLAWDGLKAYVQEAGIDPTCLPEHVVGYDSAAHPAIIATGVCPGRLELDRREMQVYLLVVGRMLETFMPPCKVECTTVDAVCAALRFRADTFRIVEQGWHGIFGRKGDIAPEDAVFLTLPDISAGETLPVPACSLVRRRSLPPPPYTDAQLVEYMEKAGLGTSSTRAAILHTLLDRKYIRYSGKYIVPTRKGLYIYETVRGMKIADPSLTSGWEAQLEDMEQGKLAQETFLKEVSRLAGEVTDEIFRLCGSKGEKSEDDTV
(1222) DNA topoisomerase 1 [Bacteroides salanitronis DSM 18170]
1
MQNNLVIVESPAKAKTIEKFLGDGYKVLSSYGHIRDLKEKSFSIDVKNHFAPIYEIPADKVKLVNDLKKEAKKADMVWLASDEDREGEAISWHLYEVLQLEPEKTKRIVFHEITKTAILNAIKHPRTINIDLVNAQQARRVLDRIVGFELSPVLWKKIKPSLSAGRVQSVAVRLIVEREREVQAFVSEALYKVTAVFANAKGEEFRAELGRRFKTKKEAQAFLEKCKKAEFEIEDITTKPMKKSPAAPFTTSTLQQEAARKLGFTVAQTMRIAQLLYENGLITYMRTDSVNLSDLALDTSREAIVSRMGEKYVQTRHYTTKTKGAQEAHEAIRPTYMSNETIEGTGQERRLYELIWKRTLASQMADAELEKTTATISISGEEDKFIAVGEVVTFDGFLRVYKESYDEGAEPEGEMRLPSALAVGQALAYKEITAMERFTQAPFRYTEASLVRKLEELGIGRPSTYAPTISTIQQRGYVEKGNREGTERPYRILSLQGGKIEESTKVELTGSEKAKLLPTDVGIVVNDFLKEYFPQIMDYNFTASVEKQFDEIAEGEKQWGDVMEHFYEGFHPLVEETMASRSEHKVGERILGTDPASGKQVSVKIGKYGPVVQIGTAEDAEKPRFAQLQKEHSLETITLEEALDLFKLPRTLGELEGKEVSVGNGRFGPYVRCDNQFVSIPKPMDPLSITLEEAVQLIREKQDAAAKRVIKTFPENPDLQILNGKYGPYISYEGKNYKIPDSIDASFLNMEACFKVIELQKEKAETRKIRHTAKRK
(291) DNA topoisomerase III [Bacteroides salanitronis DSM 18170]
7
MIVCIAEKPSVARDIADVLGAKQRKDGYIEGNGYQVTWTFGHLCTLKEPHEYTPSWKAWSLSSLPMIPPRFGIKLIEDPGIQKQFQIIERLMQAADEIINCGDAGQEGELIQRWVMQKAGAHCPVKRLWISSLTEEAIREGFAKLQDQSQFQSLYEAGLSRAIGDWLLGMNATRLYTLKYGQNRQILSIGRVQTPTLALIVNRQQEIEHFVPKQYWELKTVYRDTTFSAIVRKSDEELAEEAAQSNAPAKKKKEEDNRGIPPITDEATGKALLERISHVPFTVTDISLKKGNEAPPRLFDLTSLQVECNKKFSYSADMTLKLIQSLYEKKVATYPRVDTTFLSDDIYPKCPKILEGLKDYAAFTSPLAGQKLIKSKKVFDNSKVTDHHAIIPTGVQPHGLTDMEKNVFDLIARRFIAVFYPDCKFSTTTVTGKADDIEFKVSGKQIIDPGWRVIFAKEPKEDTKEGEEESVLPAFTKGESGPHTPMLNEKWTQPPKPYTEATLLRAMETAGKLVDNEELRDALKENGIGRPSTRAAIIETLFKRHYIRKERKSLIATPTGVELIGLIREELLKSAELTGIWEKKLREIERHSYNAKQFLDELKQMVGEIVTSVLSDNTNRRVTVMPEEPEKKKKAAPRAKKATASAPTPQPALPEGDAIIGTKCPLCGKGTILKGKTAYGCSEWKNGCTFRKPF
(475) DNA topoisomerase III [Bacteroides salanitronis DSM 18170]
7
MKTIIAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGVRGFVRDNLPIIPDTFTLVPRQVRTEKGYKPDSGVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRNLEDGGKYDNLYLAAKARSESDWLVGINGTQALSIAAGHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQLHIATDGCDGKVVKFSSSEKWKSKEPATELYNKVKATGFATVTKAERKEKTEDTPLLYDLTTLQKEANAKHGFTAEQTLEIAQKLYEKKLITYPRTGSRYIPEDVFAEIPKLLAFIGTQPEWKDKVRAKAIPTRRSVDDGKVTDHHALLVTGEKPLFLSKEDSTIYQMIAGRMIEAFSEKCVKDVTAVMAECAGVEFTVKGSVIRQAGWRAVYGEENKDETTIPGWQEGDTLTLKASSITEGKTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDCGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTMRIADVAMTGEWEKELARIERGELSADTFRKKIEAYTREITSELLSCDKLFGSRDSGCACPKCGTGRMRFYGKVVRCDNTECGLLVFRLKAGRTLSDDEIKDLLTDGHTKLLKGFKSKQGKNFDAIVAFDGDYNTTFVFPEKKCKSSYPKKRK
(1534) DNA topoisomerase [Bacteroides salanitronis DSM 18170]
3
MYHFLFPYGKPVWEEIKKTEFIMIAILTDKPSVGKEIGRIIGATKVKNGYVEGNGYMVTWTFGNMLSLAMPKDYGIQRLERDDFPFIPSEFGLMVRHIRTNNGWIPDIDAVLQLKVIEKVFQNCDTIIAATDASRDGEMTFRYVYQYLNCTQPCFRLWISSLTDESVRKGMEELKPDSFYDSLFLAADSRNKADWILGVNACYAMCKATGLGNNSLGRVQTPVLAAICRRYRERENHISSDSWPIYISLQKEGILFKMRRTQDILNKESAVMFFQDCKLAQKAQITNVSHSIREVLSPELLDLTQLQKEASIRYGLTAPEVYDIAQSLYEKKLISYPRTSSRYLTEDVFDSLPPIMTRLLSWELFPVSEKTSSIDIYTLPRHVINAKKVNVHHAIIITGIHPGNLSEKEMLVYRLIAGRMLEAFMPPCRIETTSVEAICAAQKFKAEHTRVIEAGWHDVFMRSDTVSQSGFSVNELPWLDKGDTLKVCGCNLVHKKQLPVSPFMDAELVEYMEQNGLGTVSSRTNIIRTLINRKYIRYSGKYIIPTPKGMFTYETIRGKKIADTSLTTDWEKQFAELENGMTTGQEFLDRIKVLAKEMTDDIFNTYSQRKE
(137) DNA topoisomerase 1 [Prevotella denticola F0289]
1
MQENLVIVESPAKAKTIEKFLGKDYKVMSSYGHIRDLKKKELSIDLDTLTPDYEIPDEKKKVVSELKKNAKAAKKVWLASDEDREGEAISWHLCEVLGLDEEKTSRIVFHEITKPAILKAIETPRHLDMNLVNAQQARRVLDRLVGFRLSPVLWRKVKPALSAGRVQSVAVRLIVEREREIQNFASEPYYRLNAVFAVTNEDGSKNEVKAELNKRFKTHEEALAFLELCKNARFRVASIARKPLKRTPAPPFTTSTLQQEAARKLGFTVSQTMMVAQRLYEAGRITYMRTDSVNLSALAINTSKAEIERLYGAEYGKVRMYHTHSKGAQEAHEAIRPTYIDNVSIDGTSQEKRLYDLIWKRTIASQMADAQIEKTTVNISLETEDGKNQTDLQFVANGEVIAFEGFLKVYHESSDDEEGGEEFSHALPAMHEGEELERREIVSTERYSQGPGRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVQKGDRKGEERKYVVDTLLGLKVTSRTKKEMAGADKGKLIPTDIGIVVNDFLMENFPDIMDYNFTAKVEQEFDKIAEGKVAWNKEMKTFYQGFEPEVEKVMNARSEHKAGERELGIDPKSGKPVFVKIGRFGPVVQIGSADDEDKPRFSQLPAEKSIETITLDEALELFRLPRTVGQFEGTDVVIGAGRFGPYVLHNKKYTSLPKDEDPLTISLDAAINLIQKKRLQDAQRHLKTFEEDSRMEVMNGRYGPYIAYDGKNYRMPKALHEKAAELTYEQCMDIVKNAPEPRRRKQ
(1193) DNA topoisomerase [Prevotella denticola F0289]
7
MTTCIIAEKPSVARDIARIVGANSKQDGYMEGNSYLVTWAMGHLIALAMPEAYGFSAYKAEDLPIRPTPFQLVVRQVRKDKEYVSDPAALKQLKVIRSCFDKADRIIVATDAGREGELIFRYIYQYLNCKKPFDRLWISSLTDKAIREGLSNLKPGSSYDNLYYSAKARSEADWLVGINASRALSIARKGGYSLGRVQTPTLAMVCRRYIENRDFSSVPYWKLSVEVEKEGMSLKAFGSKDYESEAAAQTALATLRSQSRLKVESVARKAGHTSPPLLYDLTALQKEANRRHGFSADKTLSIAQSLYEKKITTYPRTGSRYISEDVFEEVPVLLRKIDKALSNPLNRHSVDNAKVTDHHAIIPTGETPSGLSVDEATIYQMIVTRFLEAFSPDSEEERMQVKFTDGTNTFTWKACRQISLGWKAVQKGKEAEAEKKEDGNEQVLSLLPNLAEGEILPLVNAEITEYKTKPKPLYTEATLLSAMENAGKDVEDAESKKAMAECGIGTPATRANIIETLILRDYIRRNKKAIIPTEKGLSVYEIVKDKKIANAEMTGSWELALAAIEARQMPAEKFAQGINSYVGTICEELLALAPQVQKSYPTYHCPKCGNESVGIYTKVAKCRHEGCDFHIFREICGTLLSEDNIRDLLTTGRTPVLNGLTSKAGKKFNARLALQDDCTTAFEFENRKGKQRGR
(1395) DNA topoisomerase [Prevotella denticola F0289]
7
MIVCIAEKPSVAKDIARILGADKPCNGYMEGNNYQVTWTFGHLCELKEPNDYFANWKHWSLAALPMIPPRFGIKLIEDEGIKKQFAVIEKLYHSAELIINCGDAGQEGELIQRWVMQKAGIKCPVKRLWISSMTDEAIREGFAHLKEQQQYQPLYLAGLSRAIGDWLLGMNATRLYTLKYGNNSYGKGQILSIGRVQTPTLALIVQRQKEIDNFKPEPYWVLATVYRDTQFTATKGKYKSKEEGEQAFSTIEGKPFTVTNVTKKNGAEQPHQLYDLTSLQVDCNRKFGFSAEMTLNTVQTLYERKFTTYPRVDTQFLSDDIYPKCPQIMNGLFKTAFAGKRPYAGLVKTLGGKPLSKTKRVFDSSKVTDHHAIIPTGIPPQGLTDVEHKVYDLIVRRFIAAFYPDCKFATTTVSGKVDEIEFKVSGKEILDPGWRICTDTPASPVPSAEGQGEGTATSPLLPTFAKGESGPHTPTLTEKQTTPPKHYTEASLLRAMETAGKLVEDETLRAAMKANGIGRPSSRAGIIETLFKRHYIRRKRKSIEATDMGIALIDTIHEKLLTSAELTGIWEKKLRDIEAEKYDAAQFISELKLQITSIVNDVLADNSNRKIGQADGKEGV
(1257) DNA topoisomerase [Prevotella denticola F0289]
7
MITCIIAEKPSVARDIARIVGANTRQDGFLEGNGYVVTWAMGHLITLAMPEAYGFAAYKAEDLPIRPNPFQLIVRQVRKDKEYTSDPAALKQLKAIRGCFDRADRIIVATDAGREGELIFRYIYHHLNCHKPFDRLWISSLTDKAIREGLAHLKAGSAYDNLFHSAKARSEADWLVGINASRALSIARKGGYSLGRVQTPTLAMVCRRYIENRDFSSVPYWKLSALMEKEGVSLKAIGITDYESEASAQTALATLRSQSRLKVESVARKVTHTSPPLLYDLTALQKEANRRHGFSADKTLSIAQSLYEKKITTYPRTGSRYISEDVFEEVPTLLGKIGTALPTPLNRHSVDNGKVTDHHAIIPTGETPSGLSADETAIYQMVVHRFIEAFSPDSEEERMQVELTDGTNTFIWKACRSISLGWKAVQQGIGTNEEKGKEEEEQTLSVLPNLIENEVLPLLSSEITEHKTKPKPLYTEATLLSAMENAGKEVSDAESKRAMAECGIGTPATRANIIETLILRDYIRREKKTVVPTEKGLAVYEIVKDKRIANAEMTGSWELTLAAIEAGQMPPEKFAQGINSYVETICEELLALAPPMQKSYPTYRCPKCGNESVGIYAKIAKCRHEGCDFHIFREICGTFLSEDNIRDLITTGRTPILKGLTSKAGKKFNARLVLGEDHTTSFEFEGKKGKARGRKFTQVRRGNKLVER
(1310) DNA topoisomerase 1 [Prevotella melaninogenica ATCC 25845]
1
MQENLVIVESPAKAKTIEKFLGKDYKVMSSYGHIRDLKKKELSIDLDTLNPDYEIPDEKKKVVSELKKSAKAADKVWLASDEDREGEAISWHLCEVLGLDEDKTNRIVFHEITKPAILKAIESPRRLDMNLVNAQQARRVLDRLVGFRLSPVLWRKVKPALSAGRVQSVAVRLIVEREREIQNFNSEPYYRLNAVFAVTSEDGSKNEVKAELSKRFKTHEEALAFLELCKTSKFKVSSIAKKPLKRTPAPPFTTSTLQQEAARKLGFTVSQTMMVAQRLYEAGRITYMRTDSVNLSALAIEGCKTEIERLYGEDYGKVRKYQTHSKGAQEAHEAIRPTYIDNVSIEGTSQEKRLYDLIWKRTIASQMADAKIEKTTVNISLESEEGKNTTDLQFIANGEVVAFEGFLKVYHESTDDDENSEEFSHALPVMHEGEELERREIVSTERYSQGPNRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVQKGDRKGEERKYAVDSLLGLKITSKTKKEMAGADKGKLIPTDIGIVVNDFLMGNFPDIMDYNFTAKIEQEFDKIAEGKAEWNKEMKTFYQSFEPEVEKVMNARSEHKAGERELGLDPATGKPVFVKIGRFGPVVQIGSADDEDKPRFSQLPSDKSMEAITLDEALELFKLPRNLGQFEGTDVVIGAGRFGPYVLHDKKYTSLPKEEDPLTISLDAAINLIQKKRLQDAQRHLKTFEEDAKMEVMNGRYGPYIAYDGKNYRMPKNLHDKAAELTYEQCMDIVKNAPEPKRKK
(211) DNA topoisomerase [Prevotella melaninogenica ATCC 25845]
7
MIVCIAEKPSVAKDIARILGANKACNGYMEGNNYQVTWTFGHLCELKEPNDYFTNWKYWSLAALPMIPPRFGIKLIEDEGIKKQFAVIEQLYQSAEMIINCGDAGQEGELIQRWVMLKAGVKCPVKRLWISSMTDEAIREGFANLKEQEQYQPLYLAGLSRAIGDWLLGMNATRLYTLKYGNNSYGRGQVLSIGRVQTPTLALIVQRQKEIDNFKPEPYWVLATVYRETQFTATKGKFTSKEEGEKAFSTIEGKPFTITSVAKKKGAEQPKQLYDLTSLQVDCNRKFGFSAEMTLNTIQTLYERKLTTYPRVDTQFLSDDIYPKCPQIMNGLFQTTFAGKKPYADIVKTLGGKPLPKTKRVFDSSKVTDHHAIIPTGVLPQGLTDAEQKVYDLIARRFIAAFYPDCKFSTTTVLGKVDEIEFKVSGKEILDLGWRVCTDTPTGSSSTPSDDSQEGTNTTSPLLPTFKKGESGPHTPTLTEKQTTPPKHYTEASLLRAMETAGKFVEDETLRAAMKENGIGRPSSRAGIIETLFKRHYIRRKRKNIEATETGIALIDTIHEKLLTSAELTGIWEKKLRDIEAKKYDASQFINELKEQLTNIVNDVLADNSTRKIGEVEGDKEK
(1870) DNA topoisomerase [Prevotella melaninogenica ATCC 25845]
7
MTTCIIAEKPSVARDFARIVGAKSKQDGYLEGNGYLVTWAMGHLIALAMPEAYGFSAYKAEDLPIRPNPFQLVVRQVRKDKEYVSDPAALKQLKVIRSCFDKADRIIVATDAGREGELIFRYIYQHLGCRKPFDRLWISSLTDKAIREGLSNLKPGSHYDNLYHSAKARSEADWLVGINASRALSIARKGSYSLGRVQTPTLAMVCRRYIENRDFSSVPYWKLSALIEKEGVSLKTVGKEDYESEASAQTALATLRSQSQLKVESVARKVTHTAPSLLYDLTALQKEANRRHGFSADKTLSIAQSLYEKKITTYPRTGSRYISEDVFEEVPALLRKTGMPLSNPLNRHSVDNAKITDHHAIIPTGETPSGISTDEITIYQMVVNRFIEAFSPDSEEERMQVRFTDGTNIFTWKACRQISLGWKAVQNELVTDAEKKEKENDDELVLPSLPDLMEGEVLSLVSAEITEHKTKPKPLYTEATLLSAMENAGKEVEEDNKRKAMAECGIGTPATRANIIETLILRDYIRRDKKAIIPTEKGLAVYEIVKDKKITNAEMTGSWELALAAIEAGKMPADKFSQGINSYVNTICEELLSLTPEQKSYPVYRCPKCGQQSVGIYAKVAKCWHETCGFHVFREVCGILLSEDNIRDLISSGRTPILKGLTSKAGKKFNARLVLGEDYATSFEFENKKGKQRGK
(560) DNA topoisomerase 1 [Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2]
1
MQKNLVIVESPAKAKTIEKFLGSDYKVLPSYGHIRDLKNKGLSIDINNDFKPEYVISPDKVEVVKQLRKATKAVETVWLASDEDREGEAIAWHLYIVLGLQESNSRRIVFHEITKNAILNAIEHPRHIDLRLVNAQQARRVLDRIVGFELSPILWKKIMPSLSAGRVQSVAVRLIVEREREINNFITESFFRIRALFYLPNNKIIVQSELNKHFKTEEGAKAFLETLKDAIFTIDDINIRSSKKSPTPPFITSTLQQEAANKAGFSISQTMSIAQKLYDSGLITYMRTDSLNLSSLALNDVQKEIIDKFGDRYVKIRQYQTKIKGAQEAHEAIRPTYISNRMVAGTVQEQRLYQLIWERTIASQMADAELEKTMVTIGISNNAIDKFHLQGEVVKFDGFFRAHTESIDSKNAEAVLPPMQLNEILNLTEATASEHLTRQPLRYTEASLVRKLEKLGIGRPSTYAPIISTIQQRGYVIKGAKEGKQKLFTTLTLKNKIVSKQTKTEIVGADKNKLIPSDSGIIVNDFLIEHFPIVLEYNFTADLEKEFDKIAEGQIGWIELLHKFYNLFHPIVEKVSFTQIGCKVGERILGTDKNGKLISVKIGRFGSFVQIGSAEDEEKPQFASLVQGQSIESITLEEALALFDLPRTVGIVANKPVIVTIGRFGPYMKFDNAFISIPKEYDPYHITIEEAEKLIKEKKERDANKIIKFFSENNDLKVLNGRFGAYIAYKKNNYKIPRGIVPEIISYDDAMEIIEKNPKRKRGNIFLSRGKKS
(530) DNA topoisomerase 1 [Porphyromonas gingivalis TDC60]
1
MKNLVIVESPAKAKTIGRFLGSDYTVLSSYGHIRDLKPNKFSVDIQNNYEPEYEIPADKRPVVKELKSQADRSDFIWLASDEDREGEAIAWHLYEALGLKNKQTKRIVFHEITETAIRAAIENPRDIDINLVDAQQARRVLDRIVGFELSPVLWRRIRPSLSAGRVQSVALRLIVEREREINAFVPEASFRCTIEFVLPDGRMLTAELQKRFKTKEEARYFLEQCMDAHFHITDVAKRPGKRSPATPFTTSTLQQEAARKLGYGVAQTMRIAQKLYEEGLITYMRTDSVNLSDMALGALKKEITEHWGEQYYRFRRYKTKTKGAQEAHEAIRPTYIHRAEIDGTPQEQKLYQLIRRRTIASQMADAILEKTTITIGTDKFAETLSSQGEVIVFDGFLGVYREDSDEEHGSANTEEQLLPSVKAGDTLSLHHAKATESFTQRPARYTEASLVRKMEELGIGRPSTYAPTIQTIQNREYVVRGDKPGKTREYILLEYHKGKAITETIKTELNGQDRNKLLPTDMGLVVNDFLVASFPQVIDYNFTAKVEKEFDQIAEGKLQWQKQIGRFYNKFHPLVAEACEFDPDQKIGERMLGTDPVTGESVVAKMGRYGAMVQKGHTDKENGIKAQFASLQPGQSIESITLEEALELFLLPKKLGQYEDADVMVAVGRFGPYIKHAGKFVGLPKDTDPLSVSLDDAIKYIVDKREKEEKSLIKGFAEDPEMEIRRGRFGVYIKYKGKNYKVPKTVEDPEKLTLEECLKYVEEGETKPAKGKKKAPAKKTSAKKTAKK
(1389) DNA topoisomerase III [Porphyromonas gingivalis TDC60]
7
MKVIIAEKPSVAREIARVIRATNKKEGYIEGGDYAVTWALGHLITAAMPEAYGIKGFHKDNLPILPPVFTLIPRQIKEGKRYKADSAAVAQLKVIEKLFRECEGIIVATDAGREGELIFRFIYEYLGIAKPFDRLWISSLTDKAIKEGLARLQSGAAYDNLYYAARARSEADWLVGINATQAISIAAGRGTYSLGRVQTPTLCMVCSRFLENKKFEPQPFWQLSLAVKEGDESFRFSSADRWFDRTEATALYEKLRNASVATVETIVRKETKQEPPLLYDLTTLQKEANSRFGYSAEQTLSLAQKLYEKAYITYPRTGSRHIPEDVFAEIPALIAFLHDHPVWGVHARRLTELNAHSVDGKKVTDHHALLITGKKPIDMFGDEAVIYDMIAGRMLEAFSARCVKDVSTVTAICEGVKFILKGEIIKEEGWRAILKNSRKKDKEQLEAEERESRENGEGIIIPEWEEGEQLPLCSCSLAQGMTKPKPLHTESSLLAAMETAGKELEDEELRAQLKDCGIGTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVKGMKIGNAEMTGQWEADLARIERGELKEQEFRKGIENYATQITDELLSSKILFPKKQSDIHCPKCGKGSLVFYPRCAKCSDADCGLTLFRNVAGKSLTDEQLTQLAVNGETGVIKGFTSKAGKSFEASLSLDGEFKTVFIFPEHKKPSKSRR
(1562) DNA topoisomerase III [Porphyromonas gingivalis TDC60]
7
MVKSVHLFLRIKDKPMIVCIAEKPSVGREIAAVLGATKAYKGYMEGNGYQVTWTFGHLCALKEPHDYAPEWKRWSISSLPMIPLRFGIKLIDSDSIREQFGTIEKLVHEADMVVNCGDAGQEGELIQRWVLQKTGCTCPVRRLWISSLTEESIREGFARLRDSEEFHSLYEAGLARAIGDWLLGMNATRLYTLRFGGNRQVLSIGRVQTPTLALIVRRQHEIEYFTPEVYWEVKTIYRDTVFNATKGRFSSIEDARREVEVVAGSPFAVTSVATKKGRELPPRLFDLTGLQVECNKRFAMTADATLRTIQSLYEKKITTYPRVDTTYLSDDVFEKVPNILQGLSDYTLLTAPLRSSKLKKSKKVFDNSKITDHHAIIPTGQPSHGMSEDERRVFDLVARRFIAVFYPDCIFSQTTVLGQAAKVEFKTTGKQILEPGWRTVFTDPQTDDDGENKDEEKKLPIFSEGESGVHTPEVQEKTTQPPKFYTEATLLRAMETAGKSVKDEELRDALKENGIGRPSTRAAIIETLFKRNYIYKEKKNLKATPTGMSLIATIDYELLKSAELTGQWEYKLRRIERGDYSAADFINELKVLLTHLIPNVLKSNSSVLLSEPIPAASPAPGKKKKADKPMQKQLDLTCPVCGKGIIVRGREAFGCNAFREGCTFRLPYSEYPASLSDNELVDLLSSQKGH
(706) DNA topoisomerase III [Porphyromonas gingivalis TDC60]
7
MKCIIAEKPSVARDIARIVGATHKEEGCFSGNDHVVTWAFGHLVTLAMPEAYGFPTYSLEQLPIIPDPFRLVVRQIRKGTTYTDDPSALKQLGIIRKCFDRSDRIIVATDAGREGELIFRLIYAYLDCRKPFDRLWISSLTDKAIREGLSRPADGRQYDRLYLSGKARSEADWLVGINASRALSIARGGAYSLGRVQTPTLSMICRRYIEHRDFRSVPFWKIHALPTGLSVKAIGETTYESRRAADRAMKDLDPREALIVSSVSVQTNPVPPPLLYDLTALQKEANKRYGYTAEKTLSLAQSLYEKKCTTYPRTGSRYISEDIFEEIPSLLESLKDDPDYGDYVEKLTAGTLNRRSVDDTKVTDHHAILLTGEKSDSLTRDEEVLYRMVTVRMLESFSEAAIEETLTAILSQREHRFGIKAKRRVKSGWKAVRGSMEEPVEEGETVVDSFPEWQEGDRLDVFGFEMTEHQTKPKPLYTEATLLSAMEHAGREVADEEARKALAGCGIGTPATRAAIIETLILREYIRREKKMLIPTEKGLSVYKLVAGRKIADAEMTGAWEVALAAIEAGAMDERTFGKSIEVYTRQICEELLTTAAGNTDAHYKTYRCPLCGNDSVRVFPKIAKCVTDGCGFKVFRELCGTLLSKEHIHALMTDGCTPLLCRLTGKSGKTFNARLKLDKDGGTSFVFDSKPRKPQT
(1064) DNA topoisomerase [Porphyromonas asaccharolytica DSM 20707]
7
MIVCIAEKPSVARDIAKILGATEARSGYIEGNGYAVTWTYGHLCTLKEPEDYQTSWQGWRLASLPMIPERFGIKLIHEEHIERQFAIIQGLVSQAERVINCGDAGQEGELIQRWVLQLAGCTCPVERLWISSLTDQSIREGFANLRPSKELDTLYYAGLARAIGDWLLGINGTRLYTLTDRYGSRQRGVRSVGRVQTPTLALVVDRQAEIESFVPVTTYEMQTTYRGTLFKADTTQEVEVTFAERQQVEELIERIAKEPLVVQTVEQKKSTEYPPRLFDLTSLQVEANKKYGYTAEQTLRLIQSLYEKKVTTYPRVDTTFLPEDQYPKVGETLQGIARHAALGGFIAPLLSSGKPLKKSKKVFDNKKITDHHAIIPTGQLSSGLTPDEEQIYLLVALRYIAAFYPDAKVSTTTVRATVEEYPLRASGKTILVEGWREVLKPDSGKEGDDTTEGDKEKEQTLPTFKEGESGPHEPTIRESTSTPPRYYTEATLLRAMETAGKGVEDEELRDALKMNGIGRPSTRAAIIETLFKRGYIVREGKSLRATPAGIQLIESIQDPLLKSAELTGRWELKLRQIESREYDPGQFLNELKAQVSTLVTEVRGF
(8) DNA topoisomerase 1 [Porphyromonas asaccharolytica DSM 20707]
1
MANQKNLVIVESPAKAKTIGKFLGADYKVLSSYGHIRDLKPSSFSVDVEHHFAPIYEIPADKQRLVSELRKAAKGSDIVWLASDEDREGEAIAWHLYQVLDLKDKETHRIAFHEITKSAIQHAIQNPRSINENLVDAQQARRVLDRIVGFELSPVLWRRVGPSLSAGRVQSVAVRLIVEREREILAFQPETSFAITTRLETKGGDTFSATLPENLPSEEAARQLMQRAIDSQSTFAVQQVEQKPGRRSPSAPFTTSTLQQEASRKLGMSVSNTMRVAQALYERGLITYMRTDSVNLSSLALHDAETVILEQWGADYYQRRHYHAKSKGAQEAHEAIRPTYLRNATIQGTKQEQALYDLIRKRTLASQMADARIERTIAQIASQGADSVRLEARGEVIVFDGFISAYTESRDDEEDTSGNVLPKLREGDSLQLREIEGRQSFTKPKPRYTEASLVRKMEELGIGRPSTYAPTIQTIQNREYVRRGESQGESRDVLYLNWQHGAGNTTIKSHKQKERYGGDRGRLVPTDMGIVVTDFLMENFSRVVDYNFTADVEEHFDKVAEGEAHWQDLIGTFYDKFHPIIEEQSQSGAKRYTGERLLGTDPVSGKPVIARIGRYGPMVQIGEAPDSSLPEEERERLKPRFASIPSNLLIETITLEEALKLFDLPRTVGEFEGGDVVAAVGRFGPYLRHKGAFTSIPKSSGLTPEEITLQEAIELIEEKRRKDAASLLKSFPEDPDIVIRDGRWGAYIKVGKKNYKLTKEQKAEPTKLTYAEVVAIIAEQDNETPKKGRATAKKATSTSKKSTTKKTTSTAKKAAPKRSAASKS
(1524) DNA topoisomerase 1 [Tannerella forsythia ATCC 43037]
1
MQKKLVIVESPAKAKTIEKFLGKDYRVMSSYGHIRDLKTKEFSIDIENDYAPQYVIPAEKKKLVADLKKASQEATEVLLASDEDREGEAIAWHLAEVLDLNPQNTQRIVFHEITKNAILHALDTPRSLDIHLVNAQQARRVLDRIVGFEVSPILWRKVKPALSAGRVQSVAVRLIVEREREVNDFVAEASYRVIATFILPDGKTLLKAELNRRLKDKDEVDRFLKACREASSEFIIDDISKKPLKKSPAPPFTTSTLQQEAARKLGFSVSQTMMVAQRLYESGFITYMRTDSVNLSSLALNTAKEAIFREYGEKYHQLRKYHTKSKGAQEAHEAIRPTYMDHPAINGNAQEKKLYDLIYKRTIASQMADAELERTTISIGIGKMKDKFLATGEVVKFDGFLHVYRESADDEGEGEQENGLLPAVQVKDVLGVQEITATERFTQRPPRYTEASLVRRMEELGIGRPSTYAPTIQTIQNREYVVRGDKPGEERSFHAVTLKNGTITEAEKKEIVGADRNKLLPTDIGTVVNDFLMEYFPDIMDYNFTASVEKEFDAIAEGELVWTKALDKFYRFFHPIVEKTAAVKTEHKVGERQLGIDPKSGEPVFVKIGRYGPIVQIGLANPNDKQAPKPRFASLMKGQSIETISLEEALELFNLPRVIGTFEDKEMTAAIGRFGPFVRHDNQFVSIPKTLSPYSITAEEAIALIEEKRNKEAQRYIKKFEEEPGLEILNGRYGPYITFDKANYRIPKGVEAASLTLEECKKIIAEADEKPAKRKGAKKK
(1808) DNA topoisomerase [Tannerella forsythia ATCC 43037]
7
MKTIIAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGIRGFVRDNLPVIPDTFTLVPRQVKTEKGYKPDSGVVAQIKTVARLFKESEQIIVATDAGREGELIFRYLYHYTGCTTPFVRLWISSLTDKAIREGLRNLEAGGKYDNLYLAAKARSESDWLVGINGTQALSIAAGHGTYSIGRVQTPTLAMVCARYWENRRFTPEAFWQLHIATDGCDEGTVKFSSSEKWKEKEPATELYNKVKSAGTATVTKAERKEKTEETPLLYDLTTLQKEANAKHGFTAEQTLEIAQKLYEKKLITYPRTGSRYIPEDVFAEIPKLLAFIGALPEWKGKVQPKCVPTRRSVDGGKVTDHHALLVTGEKPLFLSKEDSTVYQMVAGRMIEAFSEKCVKDTATVTAECAGVEFTVKGSVIRQAGWRAVYSVEDKEETSIPDWREGDTLTLKGCSITEGKTKPKPLHTEATLLSAMETAGKDIEDDALRQALKDCGIGTPATRAAIIETLFKRGYMERCKKSLVPTEKGLALYSVVKTMRIADVTMTGEWEKNLARIERGEMPAETFRREIEAYTREITSELLSCDKLFARRDSGCKCPKCGTGSMQFYGKVVRCDNAECGLPVFRLKANRTLSDDEIKDLLTDGHTKLLKGFKSKQGKSFDAIVAFDGDYNTTFVFPERNTSRKFSGRKK
(884) DNA topoisomerase [Tannerella forsythia ATCC 43037]
7
MKVCIAEKPSVAREIAEVLGAWTKREGYIEGNGYQVSWTYGHLCTLKEPHDYTPEWKSWRLQSLPMIPPRFGIKLIPSDSYEKQFRILEGLIRNAEAVINCGDAGQEGELIQRWVMQKAGCRCPVYRLWISSLTEDAIREGFKNLKDESDYQRLYEAGLSRAIGDWLLGMNATRLYTLRYGQNRQVLSIGRVQTPTLALIVKRQKEIEAFKPEPYWELKTIYRETMFAATQGKFARKEEGQALLEAVTGRPFVITGVAKKKGKEAPPRLFDLTSLQVECNRKFAFSAEDTLKLIQSLYEKKVTTYPRVDTTFLSDDLYPKIPNMLKGLTDYASLTASLLSGPIRKSKKVFDNTKVTDHHAIVPTGVPPRNLTDHERKVYDLVARRFIAAFYPDCEISTTTVLGEVEKTGFKATGKQILKPGWRVIFGKETQETAEEEQPTAEENGVLPDFVKGERGPHQPDFAEKWTTPPKPYTEATLLRAMETAGKFVEDEELRDALKENGIGRPSTRAAIIETLFKRNYIRKERKNLSATSTGVELIGIIRDELLKSAELTGQWEKKLRQIEQGVYQAEAFLDELKQMVGQMVRNVRTDRTTTTITIEEMASGSKEGKNTKASAKEKPVKVKRKKQGTVTQDTASAHGSPTCPICGKGTLLRGKTAYGCSEYKSGCTFRLSYEQHGKDLSNEELLTLVRKQSFPRNP
(833) DNA topoisomerase III [Flavobacterium johnsoniae UW101]
7
MKVCIAEKPSVAREIASVLGANTKHDGYYEGNGYAVTYTFGHLCTLKEPNDYKPHWKSWDLNNLPMLPEKFETKVVQNSGIQKQFKIIKTLFDKAELVINCGDAGQEGELIQRWVMNEAHYKGEIKRLWISSLTTEAIKEGFDNLKPSENYDNLFYAGFSRAIGDWLLGMNATRLYTVKHGGYKQVLSIGRVQTPTLAMVVDRFKEIENFKPQPYWELQTLYRETLFSYEEGRFLKKEDGEILAEKVKESDFEIVSVDKKNGNEYAPKLFDLTGLQVYCNQKFGFSAEETLKIAQTLYEQKAITYPRVDTTFLPGDIYPKVPGILQKLTNYSHLTEPLLGKKIKKSPKVFNDKKVTDHHAIIPTGIEINLPYNQQQVYDIIVKRFLAVFYDDCLVANTTVIGKAADVTFKATGKEILKKGFRVVFEDPNAKEKEPDLLPSFVVGEKGPHEPSFLQKETKPPNHFTEATLLRAMETAGKQVDDEDLRELMKENGIGRPSTRANIIETLFKRQYIVRNKKQVLPTTTGIQLIDTIQNELIKSAELTGSWEKQLKDIEKGTFTAAAFIRNMKRMVEALVTEVRSETRHANISHAATIQKPAVKAEKKKAAGILAETCPKCQKGNFIKGKSAFGCSEYKSGCDFVLPYGFHDKKITESQYLRLVQKGSTVNIKGFKTDAGTVEGLIRFEENYKLKLEPKKTYIKKTTKETASDSLSCPKCKKGNILKGKTAYGCSEYKSGCDFKVTFDEVRAKLQDQKPTKELVYSILEGSV
(855) DNA topoisomerase 1 [Flavobacterium johnsoniae UW101]
1
MAKNLVIVESPAKAKTIEKFLGSDFQVESSYGHIADLPSKEIGVDVENGFKPKYEVSPDKKALVTKLKSLSKNAETVWLASDEDREGEAISWHLAEELKLDTKKTKRIVFHEITKSAILKAIDNPREIDYNLVNAQQARRVLDRLVGYELSPVLWRKIKGGLSAGRVQSVSVRLIVEREREIQSFNAVATYSIVAEFVNEAGKAFKAKLPKNFNTKKEAEDFLNKNIGSKYKVADLETKPTKKSPTAPFTTSTLQQEAARKLYLPVGITMQLAQRLYEAGLITYMRTDSVNLSKEAMDAAQAEIIKSYGEEFSKPRIFATKSKGAQEAHEAIRPTDMSRHTVNIDRDQARLYDLIWKRTLASQMSDAQLERTNVKIEADNHDELFTASGEVLLFEGFLKVYLEGHDDDEEEQEGMLPALKVNEKLANNYITATERYSRPPARYTEASLVKKLEELGIGRPSTYAPTISTIINRNYVEKGTLEGQERNYTQLTLQNSKVGEKLLKENTGSDKGKLVPTDIGTIVTDFLVKNFGNILDYNFTAKVEQDFDEIAEGNIDWAIMMQDFYNKFHPNVKEVEANAERESGERILGKDADGRQVSVRLGKFGPMAQIGEADDEDKKFASLMADQNIGNITLEEALNLFLLPKNLGEYKGEEVEVSNGRYGPYVRHGSVFISLPRGEDPLNVTKERAKELIDEKALADAPIAVYKGEAVQKGVGRFGPFIKWNGLFVNVSKKYNFDNLSQADVEELIEDKLQKNIDKVLHNWEEEGIVVEKARWGRSVILKGKIKIELSKDVDATKLTLAEVQEMIEKKAPAKKTAAKKTTAAKKTTTAKKAPAKKK
(1508) DNA topoisomerase [Flavobacterium johnsoniae UW101]
7
MKVVIAEKPSAAREIAVLLGANEKKDGYLAGNGYFVTWALGHLVGLGLPEDYGIKGFEKSSLPILPDPFLLTVRKQKIDAGYTADAGAQKQLKTIKYVVGLSDLIIVATDAGREGELIFRYIYEYLEFRKPFVRLWISNLTEKAIRKGLENLKPASELDGLYLAAQARSRADWLVGINASQALSLAQGDGVFSLGRVQTPTLALVCSRYLENKSFNIEPYWQLQLTHSRNFMLFTSISEKRWDNKRQAMDALRAIERNAATAWVSSVEIKNSTEQPPLLFDLTGLQKQASTDLSLSAGETLSIAQSLYEKQFISYPRTGSRSISADVWDEIPSLIKALGTRENFREAISTLKLGRLNKRIVSEAGVTDHHGLLPTERIPSALSGKETAIYNLIAGRLLEAVSEPCIKEITKVNLQVLHFDFILSGSRIIESGWRGVKARFLESGEPGQELPEIKRGDELKIKESAVLEKATSPPALYTEAGLLSVMENAGKKSQDLQERKILQAIGIGTPATRAAIIETLFDRKYIQRQGKSLIPTEKGLMVYELVKDKRIADVAMTAQWETELWKIENKEADAATFQKQMESYATSITKELLETPRPHDMVPDLCCPRCNINRLLITENMVKCPEKECRWVQFRNVCGVQISLADIEILLRTGRTPLLKGMKSRAGKSFDAYIVMNYKAETSFEFAKK
(308) DNA topoisomerase 1 [Marivirga tractuosa DSM 4126]
1
MSKNLVIVESPAKAKTIEGYLGKDYKVLSSYGHVRDLPKGNNAIDIENGFKPTYEVSKDKKEVIKALIKEAKLAEMIYLATDDDREGEAISWHLKEALNLDDARTKRIVFREITKSAIQNAINSPKGIDIDLVNAQQARRILDRLVGFELSPILWKKIKTGLSAGRVQSVAVRIVVEREREIEKFKAESFFKIQAFFNVEGKELKAELPGRFKTEEEAMAFLEKCLDAEFSIGKLEKKPAKKTPAPPFTTSTLQQEASRKLGFSVSQTMTLAQRLYESGKISYMRTDSLNLSDEAKEGAAKEIKSEYGADYAHTRTFKTKSAGAQEAHEAIRPTNFATKEASSDYNEQRLYDLIWKRAIASQMSDAQIEKTNVSIDISNTDQTLSASGEVVKFEGFLKVYIESTDEEEEGETNVTKGMLPPLQVGQTLDLKRMQSREGFTRPPARYNEATLVKKLEEMGIGRPSTYAPTISTIQKRGYVNKEFRDGKDRKYVEMVLENGKINRSEKTEITGAEKNKLFPSNLAMVVNDFLVEHFPNVTDYNFTAKVEQEFDEIAKGEKIWNNMIKKFYGEFHQKVDDAESIERKDVNTGRELGVDPKTGKKVIVRLGKYGPLVQLGETPDSEDENAEKPKFASLRKGQFIESITLDDAMELFKLPRELGDYEDQKMVAAIGRFGPYIRHDGKFVSIPKGEDPLDITADRAIELIEEKRKADREKFIKSFDEDPDVQVLNGRWGPYIKFGKKNVKIPKDKEPAELTYQECVELAEKTPDKKGGRKAAPKKKATKKK
(1650) DNA topoisomerase 1 [Spirosoma linguale DSM 74]
1
MSKNLVIVESPAKAKTIEGYLGKDFTVKSSFGHVRDLPKDGLAVDVTNGFRPSYEISPDKKKLVSELKSLAKSAEEVWLATDDDREGEAISWHLKEALGLRDNTKRIVFREITKNAILNAIKSPRTIDVDLVNAQQARRVLDRLVGYELSPVLWRKIKGGSTGLSAGRVQSVALRLVVEREREIDKHSAKSSFKVTAQFIVDGNKVLNAELPKNFATAAEARAFLEACVGATFTIKNLETRPAKKSPAPPFTTSTLQQESSRKLSYSVDRTMRIAQNLYEAGKISYMRTDSTNLSQEAIDKAVAEIGTEFGEKYIQTRQFKTKNESAQEAHEAIRPTNFNDRSAGGDRDQKRLYELIWKRAIASQMADAQLERTTVTIGIRFANGATTTFQTNVDDSPFVETPEAIAPNRSFPNELVAQGEVIKFDGFLRVYLESKDDEDDEDAKGMLPPLNIGQGLNLGQMKATEKFTRPQPRYAEASLVKKLEEMGIGRPSTYAPTISTIVNRGYVTKQDKPGQERKYTEYTLQQNQISETSGKETYGSEKAKLFPTNTGIVVNDFLVEYFPDIVDYKFTATVEKEFDEIADGRMNWQTMLQDFYGDFHKNIEDIQGSSVVAFKTGARDLGIDPRSGKKISARLGKYGAYAQIGESTDDEKPQYANLRDGQLIETITLQEALDLFSLPREVGFFEDKPMTIGIGKFGPYVKHDDKYVSLTKEDDPYTIDESRAIQLIQQKRAEAVSEALGEFEGKMVSTGKGRFGPYVKFEDKYVSLPRNESLAGLTLERAIELIQAKRVVEANKYIKEFPENPAVKVINGQYGPYLAIGKRNVKIPKDVDPASLTLEDCLKLGGDEPAAKAPAKKAAATKATATKAAAKPKATATATKKPAATAKKAVTKK
(966) DNA topoisomerase 1 [Weeksella virosa DSM 16922]
1
MSKNLVIVESPAKAKTIQGFLGNDFIVESSFGHVVDLPKKGMGIEIDNDFQPNYEVTPDKKEVVKKLKSLSDKAKVVWLASDEDREGEAIAWHLYNELGLDKKETKRIVFNEITKKAIQHAIENPRSIDINLVNAQQARRVLDRLVGFEMSPVLWRKIKPGLSAGRVQSVSVRLIVEREKEIQDFQPVATFCFVATFRTEENKTLPASLTQEFDSFDQAKEFIESCVGASYSVKDLQKKPAKRSPSAPFTTSTLQQEASRKLGFSVSRTMRVAQQLYESGYITYMRTDSVNLSEDALSAIKKTIQTLFGEKYAYKRKYTNKNTSAQEAHEAIRPTNFENQTIQADASMKKLYDLIWKRTVASQMANADLERTIIDIENSKNQQIFQAKGEIIVFDGFLKVYQESLDDEDIEDDKSILPKVSKGEKLDVSIIQGQEKFTRAPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEVGEIEGKNRNYRVIQLENDTITTEVKTEVYGADRRKLIPTDIGIVVNDFLVDYFSKVLDYDFTAHVEESFDKIAEGKQQWTKMIEQFYQKFHTQVEDVKENADRATGERELGIDPVSGKKVYARIGRFGPMIQIGEAEDEEKPKFASLLKTQSIHQVTLEEALKLFELPKKLGNYKGYDLEVNIGRFGPYVKFDTKYVSIPKEEDPMDITFERAAELVEEKLQADAPIAQYEGQDVTKGVGRFGPFIKWQEWFINVPKKYDFDHLSQADIEELIEAKKQKESERVVREWVEEEIRIEKARWGRFNLIHGKNKVELSKDTPVVELTLDEVKKLLGSDKTKTKTAAKKTKTTTQKSIKKK
(1807) DNA topoisomerase III [Weeksella virosa DSM 16922]
7
MKVCIAEKPSVAKDIAQVLGANQRKDGYYEGNGYQVTWTFGHLCTLKEPHDYTPTWRSWDLNHLPIIPPSFGIKLIHNKGVEKQFRIIERLVQQSTEVINCGDAGQEGELIQRWVLQKAKNNAPLKRLWISSLTEEAIQEGFENLKDGNLYNNLYAAGSARAIGDWLLGINATRAFTKKYAPFGTVLSIGRVQTPTLAMIVERQKEIDSFVIEEYWELKTLYKETEFIATIDRLKTKEKAEKGLEYLKQFPLEIIAFETKEGKEKPPRLFDLTSLQVEANKKLAYSAENTLKYVQSLYEKKMVTYPRVDTTYLSEDLHPKIEGILQKLTPYATYTASLLEKPIAKSKNIFDNSKVTDHHAIIPTGNFSSDLTIDEKKIYDMICRRFISVFYPDCLVSNTLVEAKIGDINFRTTGKQILDFGWRVLYPKDKKNQEEKEEEKTIPNFVVGEKGPHEPFIHQGKTTPPKPYTEATLLRAMETAGKQVDDEEMRDLLKENGIGRPSTRANIIETLFKRKYIEKKRKNIFATLTGIQLIDLIENNLLKSPELTGQWELKLRLIEKGEYSLEVFKEELIEMVKEVTNGVKFSIKKPIRVEPEEKTKPKREKKETQKIEELLCPKCQQHTLVKGKTAYGCRNFSDCGFVLPFEWCAKKLTNKQTVDLITKHKTAKIKGFIIDDVKVDGNLFLDENLAIQLKQS
(483) DNA topoisomerase 1 [Riemerella anatipestifer ATCC 11845 = DSM 15868]
1
MPKNLVIVESPAKAKTIQKYLGKDFEVLSSFGHIRDLPKKGMGINLNTFTPEYEVSTDKKELVSDLKAAAKKADMVWLASDEDREGEAIAWHLAQELKLKDEKIKRIVFHEITKNAILKAIENPRNIDKNLVNAQQARRVLDRIVGFEMSPVLWKKVKTGLSAGRVQSVAVRLIVEKEKEIQDFVPNSYYKTEGKFLNADNQEISAQLKKSFFEESEAKEFLTLAKNTAFKVLNIEKKPGKRTASAPFTTSTLQQEASNRLGYGITTTMRVAQRLYEEGYITYMRTDSVNLSQEAIEGAKEQIIKEFGQEYSEPRNYTTKSSSAQEAHEAIRPTDFKLKTVAGDTQLNRLYQLIYKRTLASQMANAQIEKTVVEIGNPKLPYNFEAQGEVIVFDGFLKVYGILKSEEEDAEDTEKTLPKVSVGESLTYQNIISVQKFTRPPARYTEAGLVKKLEELGIGRPSTYAPTIQTIQNREYVDKKEIAPQEREVIKLNLTSNKIDRKVLTENYGGDKNKFVPTDIGIVVNDFLTKNFAEVLDYGFTAKVEQDFDDIANGDEKWKEVLSGFYEKFHDKIEDVEENADRANGERILGEDPKTGKTVLVRIGRYGAMAQLGDSDDDNPIYSSLLSHQNINTITLEEALDLFKVPFDLEKVDGKTVSVGVGRFGPYVKWGETYISIPKEEDPLTVNQKRAEELIREKQKADAPITTFKGEPVTKGTGHFGPFLKYKNIFVNVPKKYDFENLSQDDIVELIEAKLEKEANRYIKQWEKEGISIENGRWGPFIKFNKTNFRIPKNGDEKYTAEELKEVPLEEIKKWIVAQDKNAFAEKKTTKKKTVTKKK
(484) DNA topoisomerase 1 [Riemerella anatipestifer ATCC 11845 = DSM 15868]
1
MPKNLVIVESPAKAKTIQKYLGKDFEVLSSFGHIRDLPKKGMGINLNTFTPEYEVSTDKKELVSDLKAAAKKADMVWLASDEDREGEAIAWHLAQELKLKDEKIKRIVFHEITKNAILKAIENPRNIDKNLVNAQQARRVLDRIVGFEMSPVLWKKVKTGLSAGRVQSVAVRLIVEKEKEIQDFVPNSYYKTEGKFLNADNQEISAQLKKSFFEESEAKEFLTLAKNTAFKVLNIEKKPGKRTASAPFTTSTLQQEASNRLGYGITTTMRVAQRLYEEGYITYMRTDSVNLSQEAIEGAKEQIIKEFGQEYSEPRNYTTKSSSAQEAHEAIRPTDFKLKTVAGDTQLNRLYQLIYKRTLASQMANAQIEKTVVEIGNPKLPYNFEAQGEVIVFDGFLKVYGILKSEEEDAEDTEKTLPKVSVGESLTYQNIISVQKFTRPPARYTEAGLVKKLEELGIGRPSTYAPTIQTIQNREYVDKKEIAPQEREVIKLNLTSNKIDRKVLTENYGGDKNKFVPTDIGIVVNDFLTKNFAEVLDYGFTAKVEQDFDDIANGDEKWKEVLSGFYEKFHDKIEDVEENADRANGERILGEDPKTGKTVLVRIGRYGAMAQLGDSDDDNPIYSSLLSHQNINTITLEEALDLFKVPFDLEKVDGKTVSVGVGRFGPYVKWGETYISIPKEEDPLTVNQKRAEELIREKQKADAPITTFKGEPVTKGTGHFGPFLKYKNIFVNVPKKYDFENLSQDDIVELIEAKLEKEANRYIKQWEKEGISIENGRWGPFIKFNKTNFRIPKNGDEKYTAEELKEVPLEEIKKWIVAQDKNAFAEKKTTKKKTVTKKK
(988) DNA topoisomerase 1 [Leadbetterella byssophila DSM 17132]
1
MSKNLVIVESPAKAKTIEGYLGKDFIVKSSFGHIRDLPDKGMGIDIEKDFEPTYQISPDKVKVVNELKKEAKDKEVWLATDDDREGEAISWHLKEALGLKPDTKRIVFREITKNAINKAIETPRTIDLDLVNAQQARRILDRLVGFQLSPVLWRKIKAGERKNLSAGRVQSVTVRIVVEREREIEQFKSTSTYKIVADFHVSNGKVLSAELPKNLETREQAEQFLNDCVQAIFSISSLEVKPTTKSPAPPFTTSTLQQEASRKLSFSVQQTMTLAQRLYESGKITYMRTDSTNLSAEAVAAAKDQIAKAYGEEFSKSRVFKTKDKSAQEAHEAIRPTDFSVMSAGEDRNEKRLYDLIWKRAIASQMAEAKIERTIAKIGISTRPEELTASGEVIKFEGFLKVYMEGSDEEDEESKGMLPPLNVGQTLDMLQMKATERYSRPPARYTEASLVKKLEELGIGRPSTYAPTISTVIKREYVVKEDRPGQTRDITELVLKEGQIQSAVKQETFGSEKAKLFPTNLGMIVNDYLVENFENILDYKFTADMEADFDEIAEGKVSWQKMIKDFYKDFQVKVEQAAEGASASTQSHELGVDPDSGKKIFAKVGRFGPYLQIGEATDEEKPTFVSLKKGTLISSLTYEEALDILRGPKLPLELGLHEGHPIVVNEGRYGPYVLYNGKFYNLDKGEDPLTVTKERAIALIAAKQSGAEGSLPREMSEYDGQAVTIGKGRFGPYIKWGSKYFNIPKTEDPLTMDDAKVAELIQAGQKEAANKVIKEFPENDKVKVLNGRYGPYIQIGKRNVKIPKGVEPENLTLEECLKLGSA
(1258) DNA topoisomerase III [Leadbetterella byssophila DSM 17132]
7
MKVVIAEKPSVAREIASLLGASEKKDGYLTGNGYFVTWAFGHLVGLGMPEDYGITGFDKASLPILPNPFLLTVRKVKKDKGYTADPGALKQLKVIEQVFNRSDSIIVATDAGREGELIFRYIYEYLKCKKPFERLWISSLTEKAIKQGLDNLKSGNEFNGLYQAAQGRSRADWIVGINATQALSIAAGNGIYSLGRVQTPTLALICRRYLENKDYKVKKYWQIQLLHNKEFIDFNSLSKNKWDDQKLAEDTLKSIERATSVTVTSVESKSTTEQPPSLFDLTGLQKEANKKLNLSAEETLNIAQSLYEKKFITYPRTGSKYIPEDMWAEIPNLVRALQDRESCKQAVTKMKWGRFNKRIVNDLRVTDHHGLLITDKIPSALSAKENSVYDMIAFRLLEALSQACIKEVTDVSLLALHYDFTAKGVKILEPGWRSIKGSFSDDDIEPVQDLPELKKGDELKIKEASVLEKKTKPPVLYTEAGLLSAMETAGKEIENEDERKALQNIGIGTPATRAAIIETLFTRNYIQREKKSLVPTEKGLQVYKLVKDKKIADVAMTAEWELALQKIETGESNAGTFQMDIETYATTITQELLQTSIAQTNLPKLTCPKCKSHQLIIRDKIVKCPDEACNWVQFRNVCEVQLSIADIESLITKRITALIKGMKSKAGKKFDAYIVLNEKAESSFEFEKNKSHKK
(1118) DNA topoisomerase 1 [Chlamydophila caviae GPIC]
1
MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLPAKEFGIDIDHDFEPDYQVLPDKQEVISQIRKLASSCDVVYLSPDPDREGEAIAWHIANQLPKNTHMQRISFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIRVFLQDPKTSKTFWAHLYSADGKKWEKELPKGKTEDEILLINSEAKAQHYVELLEDASYRVTRVEAKEKRRNAAPPFITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNNVRDYIQDTFGQDYLPKSPNLYATKKMTQDAHEAIRPTDIQLSPDKLQGKLTDDQFKLYSLIWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKIDDDVAEEENLSLPQLHAQDVLDKERVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFWDQFLPVVTTAEKEAVIPRVVTDIECSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAVDTPWDSPCPVCAGKMKVRHGRFGTFLGCLNYPECRGTISIHKKGEEVEKEESIPCPAIGCSGKILKKRSRYNKTFYSCSEYPDCSVIGNTIDAVVTKYTGTTKTPYEKKTTGKKKSASKSRKTTKTPAKKKKSEGKTTKTTRVGALLTPSPELALMIGDEPVARGEATKKVWKYIKDHNLQSPENKKMLVPDDKFQAIIGPEPVDMFQLPKLLNQHLFKAG
(1353) DNA topoisomerase 1 [Capnocytophaga ochracea DSM 7271]
1
MAKNVVIVESPAKAKTIEKFLGKDYKVVSSYGHIVDLPSNELGVDIQHGFKPNYLISNDKKNLVKELKALTSKAEVVWLASDEDREGEAIAFHLSETLKLKKENTKRIVFNSITKSAIENAIKNPRGIDYNLVNAQQARRVLDRLVGYELSPVLWKKIKSGLSAGRVQSVAVRLIVEREREIQDFKTQSSYRITAEFITSEGKVVKASLPKNFNTQAEAENFLQQNIGAHFKVQSLETKPAKKMPAPPFTTSTLQQEAARKLHFSVSKTMTVAQRLYESGFITYMRTDSVNLSQEALNTAKNAIVQLFGAQYSQVRKFATKSKGAQEAHEAIRPTDMSRSSIAAEPDQNKLYELIWKRTLASQMADAQIERTTVKIEADKHKEHFVASGEMVQFDGFLKVYLESTDDEEEEQEGMLPNLKKGEALTHRYITATERFTRPLPRYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVERSTLEGEVRPYQQLTLTGNSIKTQTLSERVGADKGKLVPTDIGSVVNDFLVSHFDTIMDYNFTAKVENSFDEIAEGTENWTKMLTQFYNHFHSVVENVEKHTGRETGERVLGTDPKSGRPLSVRLGRYGAMAQIGNPDDAEKPIYASLLAGMSIETITFEEALKLFELPRQLGIVDGKNVEVNVGRFGPYVRYGDAFISLDKGEDVFSITLERAKQLIGEKKKADAPIATYQGVEVTKGVGRFGPFIKWNNTYINVTKKYNFDHLSQQDVEELIEDKLKKESEKVVKEWDEGAIRIEKARWGRFTLLKGKTKVELPKDTDIATLTKEQALTLLTEKEPKAKKAPSKKK
(439) DNA topoisomerase 1 [Capnocytophaga canimorsus Cc5]
1
MAKNVVIVESPAKAKTIEKFLGKDYKVVSSYGHIADLPAREIGVDIDNGFTPKYIVSSDKKELVKELKKLTTEAETIWLASDEDREGEAIAWHLAETLNLKSENTKRIVFNSITKSAIEKAIQNPRGIDYNLVNAQQARRILDRLVGYELSPVLWKKVKSGLSAGRVQSVAVRLIVEREREIQDFKTQSSYKITAEFTNAEGKTIKATLAKGFDSYDDAQRFLQKNIGANFTVATLEKKPAKKSPAPPFTTSTLQQEASRKLNFSVSRTMTVAQRLYESGLITYMRTDSVNLSQEALQSAKNAIKGIYGEKYAHSRNFSSKTKGAQEAHEAIRPTDMSRPSITIERDQDRLYELIWKRTIASQMSDAQLERTSIKIAADKHDEMFTANGEVILFDGFLKVYLESTDEEDEEQEGMLPALTQGEKLNNNFITATQRYTRPPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVERSAFEGEQRNYQTLTLSEGEIQEKILSENVGADKGKMIPTDIGIVVNDFLVSHFESIMDYHFTANVEESFDHIAEGEEDWRKMLESFYNQFHPVVQDVEQNASRETGTRVLGIDPKSGRPLSVRLGRFGAMAQIGTNEDDEKPVFASLLSGMSIETITFEEALKLFELPRKLGIIDGNEVEVNVGRFGAYVRYGNNFASLDKGEDVFSVTLDRAREIIALKQKADAPIATYQGLEVTKGKGRFGPFIKWNDMFINVSKKYDFDQLSDTDIEELIETKLQKESEKVVKEWNNGEIRLEKARWGRFNLIKGKTKIELPKDTDTQNFTLEQATALLDTKTKKAPAKKTTATKKTTVKKSTTKAKKV
(237) DNA topoisomerase 1 [Blattabacterium sp. (Mastotermes darwiniensis) str. MADAR]
1
MKNNLVIVESPTKANTIQMFLEKNFHVVSSYGHLIDLPEKEIGIDIKENFRPNYVILPKKIKIVQNLQKLIKNYNTIWLASDEDREGEAIAYQIYKTLNIPNEKLRRIVFHEITKKAILNAIENPRLINYNLVYAQQARRILDRLVGFKLSPILWKKINYGLSAGRVQSAAVKLIVEREKKIQNFTPIPGYQIYGTFNHKKKITLHAKFEHKIEGKEKMKKILLSCINTNFFVKKIITKQENKTPPPPFTTSTLQQEASKKLNYSISKTMFLAQKLYEEGFITYIRTDSTSLSKEILSQIKNYILYSYGKQYLSKKEFSSNNKFSQEAHESIRPTDITKKTLETLELSQKRLYQLIWKRTVIGQMSDAKIETKYFYIQSSNIENFFIYTNKTIVFDGFMKIENARNENTYLSQIKKGTPLQEKEIIAKQIFTQHLPRYNEATLVNNLEKLGIGRPSTYVPIISTIKKRNYVNIQKYIKKIKLRECFFLKKNVIIEKKDKITEIEKNKFIPTEIGILTTDFLERNFQEIVDYNFTANLEKNLDNIAKGKESWHNVIKIFYEEFYNKIKKVKKNVEKIHKQRFLGFEPISNRKIFAKIARFGPIIQIGEFKDKKKPKFYPLLIHQKIDTITFRDSLKIIELPKYLGTFEEQKIFLKMNKYNIYIQHKNKIIPVEEKIFFDSLTLKKAIDIILENKKKNN
(266) DNA topoisomerase 1 [Cellulophaga lytica DSM 7489]
1
MAKNLVIVESPAKAKTIEKFLGKDYKVESSFGHIADLPSKELGVDVENDFTPKYVVDSEKKKLVKKLRDLANKAEVIWLASDEDREGEAISWHLAEELKLDKSKTRRIVFNSITKSAIQKAIENPREINYNLVNAQQARRVLDRLVGYELSPVLWKKIKPGLSAGRVQSVAVRLIVERERAIEAFTPEASFKVVAEFKTESGSSFSAKINKTFSSKKAAQDFLNKNIGANFSIANLDKKPAKKSPAAPFTTSTLQQEAARKLYFSVGRTMQVAQRLYEAGLITYMRTDSVNLSKEALDAAKEAIIQNYGKEYSEVRNYVGKTKGAQEAHEAVRPTDMKRQSPSLERDQARLYELIWKRTLASQMSDAQLERTNVKIKADKHKEEFTANGEVIKFDGFLKVYLEGHDDEETEEQEGMLPAMKVGEALLNNYITATERFSRAPYRFTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTIEGVERKYTQLVLEANNVEEKNLTETVGSDKGKMVPTDIGMIVTDFLVNHFETILDYNFTAKVEEDFDEIATGDEDWGKVMKDFYKDFHPKVEDVEQNADRASGERILGTDPKTGRQVSVRLGRFGPMVQIGTAEEEEKPQFASLLPEHSLGTITFDEAMELFKLPKDLGTYEGEEVSANVGRFGPYVKFGKKFISMEKGESALDITKERAIELIKEKQKADAPIASYEDMQVTKGVGRFGPFIKWNGMFINVNKKYDFDTLSYEDIVELIEAKKQKEIDKLIQEWPEEGIRIEKARWGRHNVLKGKIKVELAKTVDATKITLEEAKAMIEKKTPKKKTKAKAKPKAKAKPKTKK
(537) DNA topoisomerase III [Cellulophaga lytica DSM 7489]
7
MKVCIAEKPSVAREIATVLGANTKHDGYFMGNGYAVTYTFGHLCTLCEPNDYKPHWKSWDLNNLPMLPNKFKTKVVQESGIQKQFKIVKKLFDQATVVINCGDAGQEGELIQRWVIDQAAYKGEVQRLWISSLTTEAIKEGFQKLQPATKYDNLYYAGFSRAIGDWLLGINATRLYTVKHGGYKQMLSVGRVQTPTLAMIVNRYHEIENFKPQPYWELQTLYRDTLFNCEKGRFLKKEEGEAFAAKVKENDFEIVSTTKKKGKEYAPKLFDLTGLQVYCNTKFGFSADETLKIVQKLYEQKVVTYPRVDTTFLPNDIYPKVAGILQKLTNYQNLTQVVLAGKIRKSAKVFNDKKVTDHHAIIPTGVQINLQHNQQLVYDIITKRFIAVFYPDCEVANTTVLGKTDTVPFKTTGKEILKKGWRVVFENPDAKNKPEKGILPSFEKGEKGPHEPSFLEKETKPPKQYTEASLLRAMETAGKQVDDDEMRELMKENGIGRPSTRANIIETLFRRKYIERKKKQLLPTQTGIKLIGIIKNKLLTSAELTGMWEKQLKQIESGNFYAGVFINNMKKMIDDLVYEVRIEQKHIKISHAATEKAAKPVKEKKITSVQGKTCPKCKQGVLLKGKTAYGCSAYKTGCKMVLPFVYMDKKISEKQYLRLLDKGCTVNLKGFKTEHGTKEGLLRFNDDFELVLEEKKVAPKQKQTTVTDPMPCPQCKTGTVLKGKTAYGCSAYKTGCNFKYPFSVLREKAAGKALTKELVYALLSKK
(714) DNA topoisomerase 3 [Alkaliphilus oremlandii OhILAs]
2
MYHHRIERIVNMNKKLVLAEKPSVGRDLARVLNCNKKGNGYLEGQEYIVTWALGHLVTLADPENYSDRYKSWKIEDLPILPSDLKLVVIKKTGKQFQTIKEQMHRKDVNEIIIATDAGREGELVARWIIEKAKVQKPIQRLWISSVTDNAIKDGFKKLKNGKDYEKLYQSAVARAEVDWIVGINATRALTCKYNAQLSCGRVQTPTLAIIAQREAEIQNFKSRTFYGMEAMSPHLKLTWQDRKTKDIRSFEKEKITSILNAIKNKDGYVMDVEKKYKKSYAPKLYDLTELQRDANRIFGYSAKETLGIMQQLYENYKILTYPRTDSRYITSDIVPTLKDRIKACGVGPYKLAANKVLQGSIKGNSSFVDDGKVSDHHAIIPTEQFVQLSSLSDKERKVYDLVVKRFLAVLYPPFEYEETFIRAKIGEEVFIAKGKNVIHQGWKEVYGNMDEDESGNEDISEQLLPRVNKGDVLKISSITQTTGQTKPPAPFNEGTLLSAMENPVKYMKDAHKDLIKTIGETGGLGTVATRADIIEKLFSTFLIEKRGNDIWITSKGKQLLELVPEDLKSPALTADWEQKLGAISKGDLHRDHFVKEMKAYTKTVVDEIKNSDETFKHDNLTRNKCPECGKYMLEVKGKRGKMLVCQSRECGYRKGVTQNTNARCPNCHKKLELRGEGEGQIFVCSCGHREKLATFKERKKQEGSKVSKKEVVKYMNQQKKENDGFANTALADALSKLKF
(1871) DNA topoisomerase [Alkaliphilus oremlandii OhILAs]
7
MKRLVIAEKPSVAKDIAKVLNCKEKREGYIEGSDYIITWAIGHLVILCDPEEYDIRYKKWDFNTLPIIPDKIKLKPNPKTYKQYQIVKALMLSSQIDEIICATDAGREGELIFRYIYELAKCRKPFQRLWISSLTDEGIRTGFEHLKDGKAYDALYYSAKCRSESDWLVGINGSRAYSIQYGSLLPIGRVQTPTLKIIVDRDLEIDDFVPKDYWEVKADFGNYSGIWIDLEKNESKIDSIQKAEDIKNKVLLKEGLVTDFQKKKVVKKPPFLYDLTELQRDSNKKFGYTAQRTLDIAQSLYEKRKAITYPRTDSRFLTKDIIPKLKSLINKIGLEGYKEFTSILEKLEKLPVNPRIINDRKVTDHHAIIPTEKKIDLNKFSEEEKNLYDLIARRFLAVFYPDYEYFSIVMITHVAGEDFKSNEQQTIHLGWKLLYSDKEVETKESTLIHIKKGSSSTLKSAEIEQKQTKPPARYNEALLLDSMENAGKFIEDEELKEQLKSSGIGTPATRASIIERIISVGYVERKGKNLISTEKGRKLIQITSQELSSPELTGKWEKALDKIAKGNMNPQRFMEGIGRFTKFIIEDVQKNTKNVVFEGYSKNRGKKSSGTSSYNSPIGICPACKVGKVLEGPKNFYCSEYKQGCKFGIFKEDILMKKFKKKMTKTMVSKLITNQVVTVKGMVSPKTNGKFDGNICLKQSSNGYWGWEFTNGGVNN
(857) DNA topoisomerase 1 [Alkaliphilus oremlandii OhILAs]
1
MTKSLVIVESPAKAKTIEKFLGKNYVVKASVGHIIDLPKSKLGVDIDNNFEPQYITIRGKGPVLKEIKTLAKKSKNVYLATDPDREGEAISWHLARALGIEASDDCRIEFNEITKNAIKSAIKKPRPINQDLVDAQQARRVLDRLVGYQISPLLWKNVRKGLSAGRVQSVATKLIIDREEEIKNFKPEEYWTLSLKIKTKNNENFEIKFQNDNLGNKEIHTEAEVDRILNHIQNHEAIVTSVKKGEKKRNPNLPFTTSTLQQEAANKLGFSTKKTMSLAQQLYEGIDIGKSGTVGLISYIRTDSTRISQESSESCKNYIHENIGESYYHSETKERKENKGKKNIQDAHEGIRPTDVYRHPDLIKGFLSKDQYTLYKLIWQRFVASQMAPAVYDTLNVEFDINKVIFKATGSILRFEGFLKVYSYANVSENINIPDLAEGEVVTVLEQMPKQHFTQPPGRYSEATLVKTMEDLGIGRPSTYSPTISTILSRGYVEKEGKSLTATELGYIINEILEDYFSKIIDTNFTAKLEQSLDYIEEGTQDWKKLISEFYEDFKVMLLNAEEHMEEINLVEESDEKCSKCDSVMLIKHGRYGKFLACSNYPECEETKPFLYKIGVSCPKCESGDVIEKRSKKGRLFYGCSTFPDCRFVSWNRPTGKKCPTCGDILVYKKTKKSEKNICINKECGFEEEIEN
(682) DNA topoisomerase 1 [Prosthecochloris aestuarii DSM 271]
1
MASSSAAPSAKNKTLIVVESPSKAKTINKYLGTGYKVFASVGHIKDLPKKEIGLDFDNNYEPRYEVIAGKEKVVRQLRKLAGEANDIMIATDPDREGEAIAWHIANEVEGARKPVQRVLFNEITKNAIIDAISHPRQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVFRGLSAGRVQSVALRLICEREDEIGKFETREYWTLFADFTTVSGETFSAKLVKINGKDVDITNENDATAVADTILSRIYGVTDISSRIQQRKPPVAFTTSLLQQAASNQLGFGSKKTMRAAQQLYEGIELGPEGATGLITYMRTDSTRVSAEAVGQAQSYIEQQFGPQYAGQGRAGKNDKKTQDAHEAIRPTSIFRTPAAMKPFLTADQFKLYELIWKRFLASRMAPAKIELTKVEVSDHEGEFLFRANGSKVLFPGFLQVYSDQKELDYEAKTSTKDDEEKEQTVQLPKKLDLNEKLDLQTLDKKQSFTRPPARYTEASLVKELDNHGIGRPSTYAAIFSTLQDRRYVELLKRKIIPTELGRDVSLILVANFPDLFNVTFTAQMEDELDKVAAGQDDYEKVLDSFYKPLEASLSDRKKDPVLPQNDKAERCDKCGTGKMVVKWTSSGKFLGCSEYPKCKNIKPLSNSKPKPKGTGIACPGCEDGHMVLRDGRFGPFLACSNYPKCNTLLNLDKQRRIQPPKTPPLETDLSCPKCGAPLYLRTGKRGLWLGCSKFPKCRGRQAWGQLEPALQQHWQSVMDQHLAAHPQVTLLMTDGSPVNMQLTVDEIMVFAEEKGLIPLMEEQKTGVSS
(1693) DNA topoisomerase 1 [Pelodictyon phaeoclathratiforme BU-1]
1
MASKPSTPSARNRTLIVVESPSKAKTINKYLGDKYTVFASVGHIKDLPKKEIGLDFDHHYEPRYEIIPGKEKVVHQLKKLAAEADSILIATDPDREGEAIAWHISKEIGVTSKPVSRVLFNEITKTAIIAAIQAPRQIDDRLVRSQQTRQGLDKIVGYKISPFLWNVVLRGLSAGRVQSVALRLICEREAEISRFQIQEYWSIAAEFVTAGKESFKARLIRFEGDKPEIANQKQAEALAALIRKGNFAVREIAPRVQQRKQPLPFTTSLLQQAASNQLGFGSKKTMGVAQQLYEGIDLGKEGTTGLITYMRTDSTRIGEEAIAEARSYINQQFGKEYIGFGGAAKPGKNAQDAHEAIRPTSIFNKPDQVKPYLSADQFKLYELIWKRFLASMMSAAKIEQTRVDVEDSASKFLFRATGSRVLFPGFMRVYDDQKELDYEAQTSTKEEVEKELTVKLPERLAVNEPLALDDLDQKQSFTRPPARYSEATLVKDLDHFGIGRPSTYASIFSTLQDRRYVELEKKKIVPTELGKDVSLILVANFPDLFNVDFTAFMENELDKVASGEDEYEKVLDSFYKPLEAVLHLRKSNPIVPQNSEPVTCEKCGEGLMVVKWTANGKFFGCSCYPKCKNIKAISNNKAKPVDSAILCPSCKEGHMLLRSGRFGTFLACSGYPKCNTLLNLNKQRHIEPMKTPPVLTTLLCPKCGSPLYLRSGKRGLWLGCSKFPKCKGRLAWSTLDEKAQHHWEAIMAEHQKAHPTVQLTMIDGKAVPMTIPVDEIILKAEEAGLITSPSEEIVEITP
(652) DNA topoisomerase III [Lacinutrix sp. 5H-3-7-4]
7
MKVCIAEKPSVAREIAAVLGAKTKRDGYYEGNGYAVTYTFGHLCTLKEPSDYKPYWKSWDLNNLPMLPERFETKVSKDSGIKKQFNIVKGLFEKADVVINCGDAGQEGELIQRWVLNQANYKGKVERLWISSLTTEAIKEGFNNLKPASDYDNLYYAGFSRAIGDWLLGMNATRLYTVKHGGYKQVLSVGRVQTPTLAMLVNRFKEIENFKPQPYWELQTLYRDTLFSYEEGRFLKVEDGEKLANIVKTHDFEIVSIAKKAGNEYAPKLFDLTGLQVYCNTKFGFSADETLKIVQKLYEQKVVTYPRVDTTFLPNDVYPKVPAILKNLTKYATLTQPLQGKKLKKTKKVFDDSKVTDHHAIIPTGQEMNLQYNQQQVYDIIVRRFIAVFYPECKVSNTTVIGKAEKVKFKTTGKEILEKGWRIVFETPGKPTKETGMLPTFEKGEKGPHEPSFLEKQTKPPNQYTEASLLRAMETAGKQVDNDELREIMKENGIGRPSTRANIIETLFRRKYIKRNKKQVLPTVTGIQLIDTIQNELLKSAELTGKWEKQLKDIEKGEFSAVSFIKQMKQMVDRLVYEVRSENRKANITSINNKPAGAKKKKATKKAAGIASQKCPKCKQGAILKGKTAYGCSEYNKTCDFVMPFKFEGKTISEKQFIRLLEKGSTVNLKGFKIDGASAEGLVRFDDDFKLKFEPKKGKVQPKSTSEENKCPKCKKGTIIKGKTAYGCSDYKSGCDFRFSYDLIREKANGQQLTKALVFKIINEN
(724) DNA topoisomerase 1 [Lacinutrix sp. 5H-3-7-4]
1
MAKNLVIVESPAKAKTIEKFLGKDFKVESSYGHISDLPSKELGVDVEGDFDPKYQVSTDKKAVVKKLKDLAKKAEIVWLASDEDREGEAIAWHLAESLGLDKEKTKRIVFHEITKAAIQKAVENPRQIDYDLVDAQQARRVLDRIVGYELSPVLWRKVKGGLSAGRVQSVSVRLIVEREREIQAFNAEASYRIDAEFSNEEGQSFKAKLPKTIKTKAEALKFLEKNAKTTFKVSDLEKKPAKKAPAAPFTTSTLQQEASRKLYFSVSKTMTMAQRLYEAGLITYMRTDSVNLSKEAKQGAAKEIIEAYGKEYAKERNYKGKSKGAQEAHEAIRPTDFSAHSAGLDNDQVRLYELIWKRAIASQMSEAKLERTNVKIKAADHKEVFSANGEVITFDGFLKVYLEGTDDEDLEQQEGMLPAMKVGETLLNNSITATERYTRAPYRYTEASLVKKLEELGIGRPSTYAPTISTIQNRNYVEKGTVEGTERNYTQLVLKNGDVKDNLLTEKVGSDKGKLVPTDIGIIVTDFLVNHFESILDYSFTANVEDQFDDIADGKADWKKVMKSFYKDFHPRVIDVQENAERESGERILGEDPKTGKRVSVRLGKFGPMVQMGTVDDEEKPTFASLSPDQQLGSITFEEAMDLFKLPKKLGEYKDESVEVNNGRFGPYVKFGKAYVSLPKGTDPLSVEYDYAVELIKEKEKADAPIYTYKDLPVQKGKGRFGPYIKWNNMFINVNKKYDWDNLSEDDIIELIEVKIQKEIDKVVHNWEDEGIRVEKARWGRHNVIQGKVKIELPKTVDAAALTLEEVKGIIEKNAPKKKVTKRKTAAKKKTTTRKKTTAKKK
(532) DNA topoisomerase 1 [Flavobacterium columnare ATCC 49512]
1
MAKNLVIVESPAKAKTIEKFLGKDFQVESSFGHIADLPSKEMGVDVENRFKPKYEVSSDKKALVKKLKDLSKTAEMVWLASDEDREGEAIAWHLAEELKLDRSKTKRIVFHEITKTAIQKAIENPRGINYDLVNAQQARRVLDRLVGYELSPVLWKKVKSGLSAGRVQSVSVRLIVEREREIQNFTSEATYSVSAEFSNELGRTFRTKLTKNFTTKEEAEKFLQQNIGSIYKVSDLETKPTKKSPAAPFTTSTLQQEAARKLYMPVGITMQVAQRLYEAGLITYMRTDSVNLSQEAMSAAQDEISNYYGKEFSQPRSYATKSKGAQEAHEAIRPTDMSRHTVQLDRDQSRLYDLIWKRTIASQMSDAQLERTNVKIEANNHKEIFGATGEVIKFEGFLKVYLEGNDDEDEKEEGMLPALKINEILKNNYITATERFSRPAARYTEASLVKKLEELGIGRPSTYAPTISTIINRNYVEKGNFEGAERKYNQLILKNNQIKSEILSENVGSDKGKLVPTDIGTIVNDFLVKNFETILDYNFTAKVEQDFDEIAIGNKEWENMMDDFYKHFHPNVQNVEKNAERESGERILGVDPKTGKQVLVRLGKFGPMVQIGNADDEAKQFASLRAEQNIGTVTLEEALDLFLLPKMLGEYNGEEVEVNNGRFGPYVRLGKIFISLPKGEDPLDVTLDRAKELIDEKNKADAPIGQYQGMDVQKGVGRFGPFIKWNGMFINVNKKYNFDQLSSSDITELIEDKLQKESEKLIHNWEVEGIRVEKARWGRSVILKGKIKIELSKDVDAAQLTLEKVQEMIEAKAPAKKTPAKKTTPKKTTIKKK
(217) DNA topoisomerase 1 [Gramella forsetii KT0803]
1
MAKNLVIVESPAKAKTIEKFLGTDYKVASSFGHIADLPTKEIGVDTEGDFTPKYVVSKDKKDVVKKLKGLAKNAEMVWLASDEDREGEAIAWHLAEELKLTQEKTKRIVFHEITKSAILRAIENPRDIDYNLVNAQQARRVLDRLVGYELSPVLWRKVKGGLSAGRVQSVAVRLIVEREREIKDFDPQASYRIDAEFSTEDGKSFKAKIPKNFDTKEEAEKFLKDNIGANFKVADLTTKPAKKNPAPPFTTSTLQQEAARKLYFSVGKTMTLAQRLYEAGHITYMRTDSVNLSEDARKGAKEEILKAYGDKYSKTRQFKGKSKGAQEAHEAIRPTGFQKHSISGERDQQRLYDLIWKRAIASQMSDAQLERTNVRIEADKHDNHFTANGEVLKFDGFLKVYLEGSDEEDEEQSGMLPALKVQQPLNNEFITATERFTRPPYRYTEASLVKKLEELGIGRPSTYAPTISTVQSRNYIEKGSVDGTERDYVQFKLKNDKLSEKKLSETVGSDKGKLVPTATGMVVNDFLVNHFSNILDYNFTAKVEESFDNIAEGNKEWTAMMKEFYKDFHPHVQDVAKNADREVGERILGEDPESGKPVSVRLGKFGPMVQIGSVEDEEKPRFASLSPDQNMESLTYEEAMDLFQLPKKLGEYKGEAVEVNNGRYGPYVRFGKKFVSLEKGEDPLNVDFERAMELVKEKEKADAPIYEYKEMPVQKGVGRFGPYLKWNNMFINVNKKYDFDNLSNNDIEQLIEDKLQKERDKLIQHWEEEGIRVEKARWGRFNVIKGKTKVELPKTTKADELTLEEVQAIIEKNTKKKKPAKKKSTAKKKSAAKKTTSKKTAKKTTKKK
(1566) DNA topoisomerase 1 [Chloroherpeton thalassium ATCC 35110]
1
MPAKKSTTGNVGSAKGKKLVIVESPSKAKTINKYLGKDFAVYASVGHIKDLPKKEIGLDFEHHYEPRYEVIEGKEKVVREMKKLAGEADEIMIATDPDREGEAIAWHIANEVSGAKKPIRRVLFNEITARAVKEAIQETRDIDYSLVRSQQARQAMDKIVGYRISPFLWDTVLRGLSAGRVQSVALRLICEREAEIDAFETKEYWSILADFTTESGEKFTAKLVKQNGKDIEIPNEAEAKRLLDLLNARLYAISEIRRRKTKRNPPAPFTTSLLQQSASNRLGYGSKKTMSLAQQLYEGIEIGSEGAVGLITYMRTDSKRISQDAQEEARKFIQQAFGEDYTPEKPKQYKTSEKAQDAHEAIRPTSVFRKPSDLAPFLSKDQLRLYELIWKRFVASQMSPAELEQTGVDISDHEKEFIFRASGSVVLFDGFLKIFGDQRELDYEERKSTKEEASEEDAPTKLPKNLKEKESLTLDALKENQHFTKPPARYSEASLVKELDNYGIGRPSTYASIISTLLDRKYVELRQRRLNPTELGKDVSRILIANFPELFNVTFTAGMENNLDKVAAGDDDYESLLDNFYKPLEETLGVRKANPILPQNENAEVCDKCGEGRMVVKWTKSGKFLGCSRYPKCKNIKPIAVEKPKPVETGIKCSKCESGRMVVREGRFGKFLACTNYPECESLLNINKKGQVEPPKVPPLTTELACPNCGAPLYLREGKRGLWLGCSKFPKCRGRKSWNDLDDETRAKLEAAHSANLAKHPPVEIKMLDGSPLNLNAKLEDLISNASDFVKGIEESAEAEIDS
(1436) DNA topoisomerase 1 [Flexistipes sinusarabici DSM 4947]
1
MANVKSNQSPQKKGKNLVIVESPAKARTIERYLGRDFTVMASVGHVRDLPKNELGVEIEDNFTPKYKTIKGKKKIIDALKSAAKEADKIYLATDPDREGEAIAWHIATALKTKADNTYRVQFNEITKQGVNEGIKEPGRINMNRVNAQQSRRILDRLVGYKVSPLLWKPLKYGLSAGRVQSVALRLICEREEEIEKFVPKEYWTLDGYFKKSAGVPESKGEAVKARLEKKNGKKIEIPDEKKVREILNDLENKEAKVADVAKKELRQSPAAPFITSTLQQDANRKLGFTAKKTMMLAQQLYEGISLGSEGPVGLITYMRTDSTRVSSESVKQAKAFITKHFGEKFLGKGRSAKSQKKKAGTQDAHEAIRPTNVDKSPDNIKNFLTNDQYKLYKLIWDRFVASQMAPALFDQSTITITVGDYEFITKGKILKFPGFMKLYVESKENGENNEDSIIYDVEKDEKLEVKNYEEKQHFTSPPPRYSEARLVKTLEQKGIGRPSTYASIISTIIERNYVLLEEKKFRPTELGRIVNKLLISNFTNLFNAEFTAEMEKELDQVESGSKEWVELLNEFYKDFRKELNKAEEKFDADLTIDEKCPKCGKKLIIKYGKNGSFIACSGYPDCRFSCNFERDENGKIRLTDDKNGKSTGLKCEKCGSELVIKQSRCGEILACSAYPDCKNIKSFLRLKDGTLKVIEPGEKLEEKCPKCESELVVKSGKNGIFAACSSYPDCNYTANIKVDEDGNLKPQILKIDTVKCEKCDAEMVLKRSRRGSFFACPNYPDCKNTKAAVTNEDGLVTVKQKKAKSNTE
(430) DNA topoisomerase 1 [Denitrovibrio acetiphilus DSM 12809]
1
MPKNLVIVESPAKARTIEKYLGRNFKVLASVGHVKDLPASSLGVDLDNDFEPKYSIIRGKKKIIDELKKVANSAENIYLAPDPDREGEAIAWHIAEELGKKNKGKIYRVLFNEITKKGIEDGIKNTGPINENRTNAQQARRILDRLVGYLVSPLLWKSLKYGLSAGRVQSVALRLLVEREEEIEKFKPEEYWLIDVTFKGGQKALLKARLEKKNGKKYRVPNGEEAEAVLAALKAGSYNVNEVIRKEVFERAPLPFITSKLQQEAARKLSFSAKRTMMLAQRLYEGIELGSEGPVGLITYMRTDSTRVSPDATNEARGYIEKQYGKEFLSKGVKGGSKKKNVQDAHEAIRPTSVAITPESVKKILDTDQYKLYKLIWDRFVSSNMADAVYDQNTIHIANGPYLLKSQGKVMKFPGFQTLYIEGVDESKEKDQEVIFDVKEGETLNPEKHDSKQMFTQPPARYSEATLVKTLEAEGIGRPSTYASIISTLIDREYANMEEKRFKPTELGRVVCSLLIANFDRIFEPKFTAGMEEDLDSVEAGELTWKGVLRDFYAKFKPELEKAEKQFSANLKIEMKCPVCEKDLTIKYGRNGNFVACTSYPECKFTSNYERLEDGSFKLVPKEEDKPSGIECEKCGKELVFKKTRFGEVLACPGYPECKNIKNYVTLPDGEIKILAAGEEIGTPCPKCEAGLTIKGGRNGMFIGCKNYPDCDFTANMEVNEQGDIIPKYDKVDENVKCEKCGKPMVLKKSRRGKFFACTGYPECKNAKSTIVLEDGTISVKE
(677) DNA topoisomerase [Thermodesulfobacterium geofontis OPF15]
1
MILFVVESPTKIRTLQKFLRDGFIFRATLGHIKDLPKAKLGIDLKTFEPALYWLPNKKKVLSEIKKISSKVKEIYLATDPDREGEAIAYHLYEYLSKANPKLNFKRLDLIEITEKGLKLALSNLREINPYLYQSWLTRRVLDRLIGYLISPKLSKTFEKSLSAGRVQSVALRLIVEREKEIENFVPEKSYSLEIKLKRDSVTILSEFYYKNRLYKTKNKEELIKFYKEKLLNNLIILEKIEEKIEKKNPPLPLKTTTLIEISQKMLGYEPKQTMYYAQRLYENGYITYMRTDSVRVSEYAQKMVKEFIKLYFGEEFVGKERKIRQNRFVQDAHECIRPTDVFREEVPLSEPEKKLYQLIRTYFIASQMSPAKYLIRTYIFTNQNLEKDYFLKAIFKKLLFEGFLKVFKGEKEEKEFIDLKAGEIFEILAWKIKEHITEPPSPYTPSTLIKKLESLGIGRPSTYATLLDILYKRKYVTKEKGFLRPTELGKEVCEYLIKSFPEFLDYKFTSKTEEDLEKVVENKKTYQEIVSFNYEILKNYL
(887) Reverse gyrase [Thermodesulfobacterium geofontis OPF15]
6
MLFYVAKGCPNCKGIISDERLTKELPCEKCLPEKEKPSLSNFSDICKILYSQNSLKDLKPFCEVEKKIELFKKVFKNLLNTFPSSLQIGWAKRFFLGESFAIVAPTGTGKTTFGLISSLFTPKKALIIVPTKVLVKQTEEKLNQYLAKIKEPLLKNKIILAYTGSNKEKELLEKGKFDIFICTSAFLHRNFELLKNIDFSLIFVDDVDSFLKNSKNVDNLFLLLGFSKKEIELALKRDKEEKDYEDLLKIKEKHKKSIKQLIISSATLKPKTNRVLLFQNLLGFEITRFVSTLRKVIDTYIPVDLNDKKNKDEVFYQLLKVAENLIANLKEGGLIFVEESFGKSYVEVTTDYLRNKGFKVISYLEADEEELLNALKNKKVDVAIGLCHIGNPLVRGIDIPEVLRYALFLGVPKHIFPLSKSKEGFSLSISPQFLQSILISLMPLFDEEEKIIALSHINYLRRYLTLKEEQVMQYEGLYKKILNIKEFIEKKLNDPDFLENLKKSEEVFLEVDDEGNYYVIVGNASSYLQASGRVSRLTTRGLLPGLSIILVDNFKALNSLKKRLRFYLGEEVELKEVDLEKVLILDKEIREERQKLTKEKIDFKNYLLIVESPHKAKTIANFFGKPSVRRIKSVFIYEIPMENNLLSVCASLGHVFDLSRKIGIFGIIKDNNHFYPVFNTIKIDKINKEQFVDEEEIRNRDEIFDKAEIIEVLRTLSFCADQVFIASDPDAEGEKIAYDLYINLKPFQPNIKRLEFHEVTAKALRSALENPQEINIARVKAQLARRVADRWVGFSLSQQLWKVFKKSRLSAGRVQTPVLGWIIERAELAKQYKYRISFSLNGYKLSLEIEDEALAKKILEELPKNLEIKVLRYFEDELSPPPPYTTDTVLEDAFHFFRFSSSYTMQLLQELFELGLITYHRTDSTRISETGRYQVAKPYIIQTLGEEYFYPREWFSEGAHEGIRPTRPWDLAEIKLRVAHGLLTFKNPKDSFKLYDIIFRRFMASQTRKTKVLKGTFEFKLPSYSWEEDLILDIKEPGYEYFWTKPQIFKLKESLYPENIQYSKVPKVFLYNQGTLIQEMKKRGLGRPSTYAEIVSTLLQRYYVYELKNGSLVPTPLGKEVYNYLKSNYSEYVSEEFTRELEKFMDEVEEGKRDWEEICFKLLPLLNFLNISFSN
(258) DNA topoisomerase [Fibrobacter succinogenes subsp. succinogenes S85]
7
MILLVAEKPSVANQHYKPMLERIEGEKFTQGDGCLIGKNHCITWCVGHLITLAPLDAYPGFEGGWRLSNLPLLPEKFKLMEIESTRKQLGVVRDMMARADVLVNGADAGREGNLIFDLILDYTPDFRKKQIKRLWVNSYVAKDLDKAWKNLEDATERLNLSYAARLRQRADWMVGLNATRAYTLTAGRGKMISVGRVQTPTLNLVVERDAIVEQFKELFYYSVVGTWKGFQAQLVKSETKEEKGDSGTPVDEKVAADKQSNLKVAIFEKEEPAQAVIDKCSPPEEAAIAKVDIQQKKQFPQKPFDLTELQKEGNKRFKYSAQQVLDCAQNLYEKKLLTYPRTDSQYLPDTMQQEAYALAQRLASPQEKSVMRDGNENFVFINSSKVTDHFAIIPTGEEPQNLPEMEENIYKLAKERFVQAWLKPYVWSEMEVLLDAANAEIFRLKLKRNEDLGFRALVKEEKKKPSKKKKGDAGSESGDAKGADSEGKGDGDDITNIVETFPEWNLGDHAPFDSLELQKKKKSKPKYFTEATLLAAMKTAGKQIENEELAEAMKERGLGTPATQAGIIETLKKRGFIEAQKNYLVSTQRGREVIELMDEKVKSPEMTGEWEFKLSQVEKGKLTPIEFRDGIVNYVKELFEHLRQKYGSQFERETVTDAIPCPKCSSPLEIAPWGYVCKNEECGFKAGHTIAGRTLSHAEMRTLLRTGKSDLLSGFKSKKGTTFSATLTLGDDGNIGFEFSDDARAKTPTNYKCPKCGKTLLDSGNRLICEGSDVTTSNNENGDPTLTPDTAPTCDFVFYKTIAGHVMSDEEIAELFNNGTTQIISGFLTKKGTTFNAKVVWDKDFKATFAFENDGHFHGTETKFNCPLCKKKLEENKNAIFCPACNFTLFKSVAGKKLRVADIKALLTGGKTELLTGFKSKKGTEFDAYLKLGEDGRTNFEFVHRDLPCPCCGDQLRFRSGTTTQTPNGEVQTLAAYVCMNPACNYGIPKTFFKREFSDEEVETLLKNKSTPILEPFKKNDTTFRAALELREGGKIAFNKLTVEVIKKC
(778) DNA topoisomerase [Fibrobacter succinogenes subsp. succinogenes S85]
7
MATTKTTTKATKTTATKTAAKATKTAKAAVEGKTLIIAEKPSVAADLVKVLGAKSFKKETAYYESDTTIVSHAIGHLVGIADPKDIDERYKAWDMKTLPMLPEKFPLVALPTTKAHLSALGKLIKRKDVTTIINACDAGREGELIFYYIVDYILKGNFKGKTFKRLWMQSMTPAAIKDAFEHLRTEEDMVNLRNAALCRSEADWLVGMNGSRGLTAYNSSMGGFQITPCGRVQTPTLAIIVKREEERNRFIPQKFWTIEASFDNAGAGYQGKWFTVDKENGKDRVKQIFDEARAQEILAKCKGKTGSIEETTAPSQQKCGQLYDLTTLQREANNRFGFSAKTTLSIAQSLYEHYKATTYPRTDSRCLPEDYVAPVKATLGKIEGPLAKFAQEALDKNYVKRTPKVFDNSKISDHFAIIPTGVVPKGLSEAEEKIYTMICQRFIAVFFPPAQYLNTTRITTVENETFITEGKILVDPGFKAIYGKESDEESNIPKLNGNTAKTLAIESKEDFTKPPAHYTESTLLSMMESAGKLVEDDELRDAMKERGLGTPATRAAIIEKLVSDKYVVRDGKEMIPTAKAFDLIKVLSAMNCEALTSPELTGEWEYKMDLISKGKESREAFMNGIIEMTKTMVKNIKGFKEESTTGEASFSPVNGKKVFETVSRYTTEDGIVIRKITGGKHLSESEIVELLTKRKIGPLTGFRSKKGAEFSAGLIINDQNKVEFVFEEKPEEIELGEVIGKSPVDGSDVYETLTGYVSESYVKKEPSGLSLPKILLGKEIPLDDIKKLLAGEKTSLIKGFRSNKTRRLFDAYLTLVKGKLKFDFPPREFKPRRFAKKAAPKGE
(777) DNA topoisomerase [Fibrobacter succinogenes subsp. succinogenes S85]
7
MATTKTTTKATKTTATKTAAKATKTAKAAVEGKTLIIAEKPSVAADLVKVLGAKSFKKETAYYESDTTIVSHAIGHLVGIADPKDIDERYKAWDMKTLPMLPEKFPLVALPTTKAHLSALGKLIKRKDVTTIINACDAGREGELIFYYIVDYILKGNFKGKTFKRLWMQSMTPAAIKDAFEHLRTEEDMVNLRNAALCRSEADWLVGMNGSRGLTAYNSSMGGFQITPCGRVQTPTLAIIVKREEERNRFIPQKFWTIEASFDNAGAGYQGKWFTVDKENGKDRVKQIFDEARAQEILAKCKGKTGSIEETTAPSQQKCGQLYDLTTLQREANNRFGFSAKTTLSIAQSLYEHYKATTYPRTDSRCLPEDYVAPVKATLGKIEGPLAKFAQEALDKNYVKRTPKVFDNSKISDHFAIIPTGVVPKGLSEAEEKIYTMICQRFIAVFFPPAQYLNTTRITTVENETFITEGKILVDPGFKAIYGKESDEESNIPKLNGNTAKTLAIESKEDFTKPPAHYTESTLLSMMESAGKLVEDDELRDAMKERGLGTPATRAAIIEKLVSDKYVVRDGKEMIPTAKAFDLIKVLSAMNCEALTSPELTGEWEYKMDLISKGKESREAFMNGIIEMTKTMVKNIKGFKEESTTGEASFSPVNGKKVFETVSRYTTEDGIVIRKITGGKHLSESEIVELLTKRKIGPLTGFRSKKGAEFSAGLIINDQNKVEFVFEEKPEEIELGEVIGKSPVDGSDVYETLTGYVSESYVKKEPSGLSLPKILLGKEIPLDDIKKLLAGEKTSLIKGFRSNKTRRLFDAYLTLVKGKLKFDFPPREFKPRRFAKKAAPKGE
(257) DNA topoisomerase [Fibrobacter succinogenes subsp. succinogenes S85]
7
MILLVAEKPSVANQHYKPMLERIEGEKFTQGDGCLIGKNHCITWCVGHLITLAPLDAYPGFEGGWRLSNLPLLPEKFKLMEIESTRKQLGVVRDMMARADVLVNGADAGREGNLIFDLILDYTPDFRKKQIKRLWVNSYVAKDLDKAWKNLEDATERLNLSYAARLRQRADWMVGLNATRAYTLTAGRGKMISVGRVQTPTLNLVVERDAIVEQFKELFYYSVVGTWKGFQAQLVKSETKEEKGDSGTPVDEKVAADKQSNLKVAIFEKEEPAQAVIDKCSPPEEAAIAKVDIQQKKQFPQKPFDLTELQKEGNKRFKYSAQQVLDCAQNLYEKKLLTYPRTDSQYLPDTMQQEAYALAQRLASPQEKSVMRDGNENFVFINSSKVTDHFAIIPTGEEPQNLPEMEENIYKLAKERFVQAWLKPYVWSEMEVLLDAANAEIFRLKLKRNEDLGFRALVKEEKKKPSKKKKGDAGSESGDAKGADSEGKGDGDDITNIVETFPEWNLGDHAPFDSLELQKKKKSKPKYFTEATLLAAMKTAGKQIENEELAEAMKERGLGTPATQAGIIETLKKRGFIEAQKNYLVSTQRGREVIELMDEKVKSPEMTGEWEFKLSQVEKGKLTPIEFRDGIVNYVKELFEHLRQKYGSQFERETVTDAIPCPKCSSPLEIAPWGYVCKNEECGFKAGHTIAGRTLSHAEMRTLLRTGKSDLLSGFKSKKGTTFSATLTLGDDGNIGFEFSDDARAKTPTNYKCPKCGKTLLDSGNRLICEGSDVTTSNNENGDPTLTPDTAPTCDFVFYKTIAGHVMSDEEIAELFNNGTTQIISGFLTKKGTTFNAKVVWDKDFKATFAFENDGHFHGTETKFNCPLCKKKLEENKNAIFCPACNFTLFKSVAGKKLRVADIKALLTGGKTELLTGFKSKKGTEFDAYLKLGEDGRTNFEFVHRDLPCPCCGDQLRFRSGTTTQTPNGEVQTLAAYVCMNPACNYGIPKTFFKREFSDEEVETLLKNKSTPILEPFKKNDTTFRAALELREGGKIAFNKLTVEVIKKC
(1571) DNA topoisomerase [Pedobacter saltans DSM 12145]
7
MKVVIAEKPSVGRELAKVFGATTRKDGYIEGKGYTFTWAFGHLLQLAPPQEYGFYGWRKENLPMLPQKFKLSIRKIKTKDGVVEDPAVKKQLDTIKRLFDECDEIIVATDAGREGELIFRYIYYYLKCKKPFRRLWISSQTDEAIKNGFRNLKPGTEYDTLFNSAHARSQSDWLVGMNATQALSISAGNKSVLSLGRVQTPTLAMICARFLEIKNFVPKIYYQVAIQLCKDEQFFKAISTKNFDTKEEAEEVLAKVLDVESGSPTGGHIKNVEGKAKKEPPPLLHDLSSLQQEANKKKGYTADQTLGILQNLYESKLVTYPRTGSRYIGDDIFATVPDLISKYKNHGLFGKSAEYLLENKLNKRSVNAKKVTDHHAVLPTGIDPGYLPEDKQAVYDMVVGRMLEAFHQDCIKETTKISIESGSDFVANGTVIKIAGWRSVFNDPDDEKKDASENATLPKVDKGENLPVTKKAVVEKQTKPKPQYTEATLLKALETCGKDIEDEELRYAMKDSGLGTPATRAAIIETLITREYISREKKNLIPTSKGLAIYEVVKEKKIAQAELTGQWEKRLEEIRGGASVLDFKNEIIDYTRNITQELLAAGIGLEKVLVTG
(35) DNA topoisomerase III [Pedobacter saltans DSM 12145]
7
MKAIIAEKPSVAREIATLLGATEKRDGYLTGNGYEVTWALGHLVGLAMPEDYGVSGFQREALPILPNPFLLTVRKIKKDKSYVPDNGALKQLNIIEQVIGRCDSIIVATDAGREGELIFRYIYEYLKCRKPFERLWISSLTEKAIKQGFDNLKAGSDFDGLYRAGQGRSKADWLVGINASQALSISAGRGVYSLGRVQTPTLALICKRYLENKDFAVKKYFQIQLEHRKEFTDFKSLSKTKWDDRKLADDTLKSIQRNGTATVTAMETKTVTEQPPLLFDLTGLQKEANKRASYTAEETLNIAQSLYEKKFITYPRTGSKYIPEDMWSEIPALVRNLEARASCKKAVGKVKWGRFNKRIVNDVKVTDHHGLLITEKIPSELTAHENVIYDMIAYRLLEALSSACTKEITDIGLQAFHYDFTLKGCKIIEAGWRGIKGKFTDEDSDPVQELPELKVGDELKIKVASVLEKITKPPVLYTEAGLLSAMENAGKEIDNEDERKALKDIGIGTPATRASIIETLFKRDYIRREKKSLIPTHKGLQVYGAVKDKKIADVAMTAEWEMALQKIENNDANADAFHRDMETYATFITRELLDTGIAKEKQPELTCPKCKSRQLLVWNKVVKCPDEACGWLQFRIVCGVPLSVADIESLVTKGKTNLIKGMKSNSGNKFNAYIVMNDKAETSFEFENRKPKRK
(1349) DNA topoisomerase III [Pedobacter saltans DSM 12145]
7
MKTIIAEKPSVAREIAGLVGASDKKDGYLTGNGYFVTWAFGHLIGLGMPEDYGISGFDKASLPILPNPFLLTVRKVKKDKGYTADTGALKQLKVIEQLFKQSNSIIVATDAGREGELIFRYIYEYLKCNKPFERLWISSLTEKAIKQGFNNLKDGAAFDGLYQAAQGRSRADWLVGINATQALSIAAGNGIYSLGRVQTPTLALICKRYLDNKNFTVKKYWQIQLTHNKAQVDFKSISATKWDEKQLADDTLKAIQRGATATFTSVETKSVTEQPPLLFDLTGLQKEANKRLKLSAEATLNIAQSLYEKKFITYPRTGSKYIPEDMWAEIPNLVRALQNREDCKQALTKIKWGRFNKRIVNDLRVTDHHGLLITDKVPSVLNADENKIYNMIALRLLEAISQACVKEITDVSLQVLHYDFTAKGCKIQEAGWRSIKGSFTDDGEEPVQELPELHKGDELAIKEAAVLEKQTKPPVLYTEAGLLSAMETAGKEIENEEERKALKNIGIGTPATRAAIIETLFTRNYIQRDKRSLIPTEKGLQVYGLVKDRKIADVAMTAEWELALQKIENNEADAGTFQKEMETYAKSITDELLQTSIASTNQPKLTCPKCKSQQLIIRDKIVKCPDEACNWVQFRTVCGVQISIENVTNLVNKGKTSLIKGMTSKAGKKFDAYIILKENAESSFEFEKNKSSKRNGK
(1102) DNA topoisomerase 1 [Pedobacter saltans DSM 12145]
1
MAKNLLIVESPAKAKTIEGYLGKDFLVKSSYGHIRDLRKDDGAIEVDNNFKQHYEIPADKKQVVAELKKLAKSAETVWLASDEDREGEAIAWHLYESLGLKENQTKRIVFHEITKPAITKAIENPRTIDYNLVNAQQARRVLDRLVGFELSPVLWKKVKPSLSAGRVQSVAVRLIVEREREINLFNAESAYKIIAIFSTGKGKEIFKAELSQRYAEQKEAEKFLEDCKSALYKINDLDIRPTKRTPAPPFTTSTLQQEAGRKLGFSVSRTMSIAQRLYETGKITYMRTDSVNLSETALNASEIEINSAYGSKYHHKRIFKTKSAGAQEAHEAIRPTHFEWHTIEGDASEKRLYELIWKRAIASQMSEAQFEKTTARIGISTRKEELVANGEVLKFDGFLKVYLESEDEESDSHLDDKTDNGILPPLNIGQELILNEMTALERFTRPAARYSEASLVKKLEELGIGRPSTYAPTISTIQNRGYVVKEDRDGRSRTYKTFTLKDGEVKSIVKSEITGTEKGKLFPTDIGAVVNDFLVEHFKGIVDYNFTATVEKQFDEIANGLKEWTDMLKKFYQPFHSEVEDTLKNADRATGERLLGLDPESGKNVYTKVGRFGPMVQIGEMDEEDKPRYASLLKSQSVETISLEEALNLFQLPFQLSDYKDKEVSVGVGRFGPYVKWGDTFISLPKNEDPLTVTNERAIEIIEEKISIDAPVAEYQGHPVSKGKGRFGPFLKWKDLFINVPVRYNFDKLSQSDINELISAKIEKEANRYIQQWETEKIAIENGRWGPFIRFGKQMLKLGKNPTTGQKYTAEELSTVSLEDVKKLIVEQVPDAFDAKAKKTGRKTTKK
(200) DNA topoisomerase 1 [Desulfurispirillum indicum S5]
1
MGKKKLVIVESPAKAKTINRYLGNNFTVKASVGHVRDLPKSTFGVDLENNFEPKYVTLRDKKKVIDELKSAASRVDEVFLASDPDREGEAIAWHISEILQKENKGLAIKRVLFNEITKKAIVQALEHPGEIVQPKVDAQQARRIIDRIVGYKISPFLWEKISRNLSAGRVQSVALRLVCEREKEIDAFVTEEYWSVVTQFIKDEVPFQAKLFRIKEKKAQIKDGDTAHAIVDALKKGSFTVGTVEKKQKRKRPMPPFTTSKLQQDASRKLRFSAKKTMMVAQSLYEGVNLGEYGQTGLITYMRTDSTRLSQDAIDMAREYIGKTFGPDYLPEKPRVYATGGKTQDAHEAIRPTTSLNPESIKAHLTGDQYRLYKLVFDKFLASQMADALIDATAADIINGDYTLRATGSVVAFAGHLALYQAVEESAKKEEDILPPLHQGDKLTSEDIQALQHFTQPPPRYTEATLVKTLEEKGIGRPSTYASILSTIEDRKYVEKEDRKFTPTERGKIVNELLVNHFPELFEYSFTANLEAKLDRIEEGEENWKDTLGNFYEGFQRELEKAKESLKHVDKINIKSGVACPKCEAELVIKSGRNGEFLACIRYPECEFTSNFTKEEDGSITIVQRPAEEMTSIACDKCGKPMAIKMSRRGPFLACSGYPECKNPKSFRREEDGTIVVVEKKPAEPTDIACEKCGAPMVIRASRRGEFLACSAFPKCRNTKNMERDEQGKAVIKEKKATAKEPGEKAAAPKAKAAAKKAPAKKSAAKKK
(331) DNA topoisomerase III [Niastella koreensis GR20-10]
7
MKVCIAEKPSVARDIAAVIGAKQKKDGYLEGNGYQVTWTFGHFCTLKEPHDYTDQWKYWRLEDLPMIPPNFGIKLIPNDGVQKQFKVIEQLVQNCEEVINCGDAGQEGELIQRWVLLKAQCNAPVKRLWISSLTEDAIREGFKKLKDSNQYDNLYAAGSARAIGDWLLGMNATRLFTKKFAQGKAVLSIGRVQTPTLAMIVARQKEINAFVSEEYWELKTIYREVEFTAAIDRIKVLDRAEKGLAYLKEHPFEITSFERKDGKEGNPRLFDLTALQVEANKKFAYSADDTLKYVQNLYEKKMVTYPRVDTTYLSEDLHPKIEGILRDLTPYAALTASILANPIPKLKTVFDDKKVTDHHAIIPTGVYPSNLPAEEKRIYDLIARRFIAAFYPECKISNTTVLGKVGQVPFKVTGKQILEPGWREVYANDVKTEKEKEEEEEKVLPVFVVGESGPHTPRIHKGKTSPPKAYTEATLLRAMETAGKQVDDEEMRELMKDNGIGRPSTRANIIETLFRRKYIEKKKKNIYATQTGIDLIDTIQTELLKSPELTGIWERKLRLIEKGEYPKDTFKQELIQMVIDLTAEVKTATYRAITVVEQQPAKKEKDTPDKPKKEAKPKEPKKAVAIEEQQCPKCKSHPLKKGNTAYGCANFKVCGFKVPFEVFGKKLTDKQIADLLTRGKTGKAKGWVVAGAEKEGKLRFSDAFDLEIE
(1494) DNA topoisomerase 1 [Niastella koreensis GR20-10]
1
MAKNLLIVESPAKAKTIEKILGKDFEVKSCFGHIRDLEKEEMGIDIKNGYQPRYKVPADKERVVKELKSLANKSDEVWLATDEDREGEAISWHLCEVLGLDPSTTKRIVFHEITKPAIQKAVTSPRLLDMNLVNAQQARRVLDRIVGFELSPVLWRKISARGSNLSAGRVQSVAVRLIAEREREINAFQATSTFKIEALFTTPDITGKNVTFVAEGKKYDTAENAEKFLQTCIGAKYKVNDIQVKPGKKSPAAPFTTSTLQQEASRKLGYGVKRTMTLAQRLYESGNITYMRTDSVNLSDTAMAEIRKQVTGQYGNNYYQPRKYKNKNESAQEAHEAIRPTYMENSTIDDPDCKRLYELIWKRTMASQMADAELEKTIAKIEISTNKEELTASGEVLKFDGFLKVYREDRDEEDITDDEQQEGMLPPLTVNQQLPLNEMKAIERFSRPSPRYTEASLVKKLEELGIGRPSTYAPTINTIQERKYIEKRDKEAVKRNFRILTLKEDKISKVTEQENTGAEKSKLFPSDLGLVVTDFLKQYFDDIMDYGFTARIENEFDEVAAGKLKWNNMIDDFYLPFKKDVDNTIETAERAKGERELGIDPQSGKKITARIGRFGPMVQIGDANEEEKPRFAGLRRGQSIETITLEEALKLFELPKTLGEHEGQEIVVNMGPFGPYIKFGEQNISMPRGIDPNDVNMEKALEFIADKQKADAPIAHYDNKPVTKGTGRFGPFIKWNNMYINVPKKGYDFENLTQDDIDKLIEGKIKKEENRYIQNWPDEKISIENARWGPVLKFGKKILKVGRKADDTKYTAEELVSVPLDDVKKMIEAQVPNAFASKKAAAKKAPGKKAAPKKDATKKKAAPKKK
(98) DNA topoisomerase 1 [Chlorobium tepidum TLS]
1
MASKSATPSARNRTLIVVESPSKAKTINKYLGDDYTVYASVGHIKDLPKKEIGIDFDNHYEPRYEVIAGKEKVVRQLKKLAGEADKVLIATDPDREGEAIAWHISNEIDFAKKPVFRVLFNEITRNAIIEAIGHPQQIDYRLVRSQQTRQALDKIVGYKISPFLWNVVYRGLSAGRVQSVVLRLICERETEIEAFTPQEYWTIYADFTTENGETFRTKLVKVNGEKPDITSGEQAEAIASAIQGRLFAISEIVPKVIQRKQPLPFTTSLLQQAASNQLGFGSQKTMRTAQQLYEGIDLGSEGATGLITYMRTDSTRISGEAVAQAHDYISQQFGPEYKGFGGQGKAGKNAQDAHEAIRPTSVTRTPESLRRHLTPDQFRLYELIWKRFVASMMAPAKIEQTRVDVDDQKKEFVFRATGNKVLFPGFFRVYDDQQELDYEAQKSTREELEKEQIVKLPERLSVDEQLKLAELDRRQSFTRPPARYTEASLVKELDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTELGRDVSAILVANFPDLFNVRFTAEMEDELDKVASGDDEYEKVLDRFYRPLESVLSHRKSDPLIPQNRDAVLCEKCGKGHMIVKWTTSGKFLGCSNYPKCKNIKAITTNKAKPKETGVRCPVCGEGHMLLRNGRLGPFLACSNYPKCNTLLNLSKQRHIEPIKTPPITTDLACPKCGAPMYLRTGKRGLWLGCSKFPKCRGRLSWSTLDPETQARWEKAMNEHMAAHPSLAITMLDGKPAPMNLPIEDIIARAEDAGLISATSEQPEAEATT
(206) DNA topoisomerase 1 [Elusimicrobium minutum Pei191]
1
MATKKTTTKKTESLSKGKNLVIVESPTKQKTISKILGADYVVKSSFGHVRDLPSKEIGVDEKNGFKPKYVPVEKAKKMVSELEKLAKGSEYVYLATDPDREGEAIAWHLVELLKIPVEKIRRIFFHEITPAAVKASFDHARNINKDLVDAQQARRVLDRLVGYKLSPLLWKKITGGLSAGRVQSVAVRLLAERAKEIENFREEEYYSLTSELEKQGETPKFNARMLKWRGKNTEIITTYHLFAEDYKVKTTVFKKPEDLAPVNSLLRQGPLTVSKIEKKEVKQKAKPPFITSSLQQEAYNKIGFPSQKTMMTAQSLYEGVEIAGEVVGLITYMRTDSFNVSKDLQSQTKKFIAGKYGDDFVPPTPNFFKSKVKGAQEAHESIHPTDVYKTPASIKDYLSADQYKLYELIWLRFIASQMADAVFNTVSVDITAGKAEECVLRATGRTVKFPGFLSVYKEDDSEEEDEGSALLPNLTEGDDLNLIDIVTKSHKTAPPPNYNEASLIKTLEKHGIGRPSTYAPTIKTILDRKYIIRQPKTNKLIVTDLGVTVTDQLKDFFKDIMDLSYTAGIEEKLDDIAEGDNDWVKVIGDFYEGFKKDLATADKDMQRAAPKPSDEKCPLCGSPMVIRRSRFGEYLACSTYPECKGKINLTSSGEKLAPEVTEEKCEKCGSPMVIRSGRRGKFMACSAFPKCKNTFSIDASGNKVASSGPIETKIKCEKCGKPMLLRASKRGEFLGCSGYPKCKTIVSVSPEEIAKIKKEHEAENK
(1044) DNA topoisomerase 1 [Candidatus Chloracidobacterium thermophilum B]
1
MTKGLVIVESPAKAKTITKYLGKDFTVLASYGHIKDLPEKELGVDVEHGFEPTYEIIPDTKKRNNSKTVRELKSAARKAESIYLAADPDREGEAICQHLREELVGDKEQKPVYRLLFNEITKDAIQASLQSPRQINQALVEAQQARRVLDRLVGYEVSPMLNRGLGGGKVALSAGRVQSVALRLVVEREREILAFQPTEYWTFDARFAAALPPEFTAKLFSIHGETLKTGDFDKQRRNERHVRTEAEARDLERQLREVAEWRVAAVTTREKKRHPVAPFITSTLQQEASRKLSFPVKKTMSLAQKLYEGIELGAEGSVGLITYMRTDSTRIADSAIAEVRDFIAAQYGANRLPAKPNQYKNKKGAQDAHEAIRPTSVWRTPEKVAPYLEADELALYRLIWQRFVASQMTPALFDATTIDIEGGPGFVFRATGAVLRFDGFLAVYEEGKDELDADDEALARKLPQVAAGERVECRELQVNQSFTRPPARYTEATLVKTLEERGIGRPSTYAQTLSVIQARNYVEKRDGRFHPTPLGMVIADVLTENFADLFDPGYTAVLETQLDEIEEGKLNWREALEEFYRKFRADLEAAKANLKKAKEGVATDERCHKCGAAMVLKLGRFGKYLACTNLECRATRDYGTLPTATSDPGTAAEAVGEIACDACGRPMVRKRGRWGEFLACTGYPECKTTRNLTRTGAPKPAPVQLDEACPTCGQPLAVRQGRYGEFIGCSNYPKCTYIKREAIMPCPRPGCGGDITERRSGRGRVFYKCTNTACDVVYWDKPVTHPCPSCGAPFTLQKTNAQGETYHYCADKEHCGWTELPAEKRKKKDTLPASKNPSASEAA
(1536) DNA topoisomerase 1 [Candidatus Koribacter versatilis Ellin345]
1
MAKGLVIVESPAKAKTIQKYLGKGYEVEASLGHIKDLPKKGLGVDIENNFDTEYVVIPGKEKVVAKLKKLAKDADAIYLAPDPDREGEAIAAHLAEELGDGDGKKKKKTDSKPFYRVTFNEITKKAVQEAFAKPREIDRNLVDAQQTRRILDRLVGFQVSPLLWDKVRRGLSAGRVQTVALRLIVEREREIKAFVSKEYWTIDAHLHGQKPPDFDARFTGIDGEKLEVGNEEESKKIVDQLDNAEWSVRSVDNRERRRNAAAPFTTSKFQQDASRKLGMSVKRAMMIAQHLYEGVELGEEGTVGLITYMRTDSTRVSNEALTEVRELIGTSYGPQFLPESPNVYKQKKDAQGAHEAIRPSSVAHTPDDLKAYLKDDEMKVYKLIWQRFVASQMAPAVFDQTTVDIDAKADRTYNFRVTGSVLKFEGFLKVYEESKEGKDEEDDALKHKLPPLVEGQTLTLKAIKPEQHFTEPPPRYNEASLVKELEEQGIGRPSTYAAILSTIQDRGYVQKTPGRGGKFFPTEIGMVVTDLLVANFKDIFDTKFTSRMEEELDEVEDGQKKWTDTLKEFYDKFETNLDYAQKHMENIKRMEKPTDEKCERCGSPLVIKWGKHGSFYACSSYDKKDPNSCTFTKENPIDLPDLDTADVQETEQEEYCENCGRGMVLKRGRFGQFMACTGYPECKTTRRLDQAKKIPDVPLDEKCPECTRPLVLRHGRFGEFVSCSGYPECKWIKQNFVGVKCPQCKEGEIVEKKARRGNFFYGCARYPKCDFTSANKPVAQPCPKCGSEYVLEKKLKSGTYLTCPNNKATASEEPKRRGKKKAAETENAVKCDYSVKIAEPENTDEPEKSADVA
(757) DNA topoisomerase [Candidatus Solibacter usitatus Ellin6076]
7
MAGADSGNVAVLAEKPSVARDIARVLGAGTKGEGFLHGNGYVVTWAIGHLAALAQPGEIDPQWRPWRRNTLPMLPRQWPLVVYEKTKDQFETVKRILNSPKIARVVCATDAGREGELIFRYIYEAAGCEKPVSRLWISSLTPDAIRKGFDALRPAADYDGLADAARGRSRADWLVGMNLSRAYSLAYSEDLSVGRVQTPTLAMLVERELTVRNFVPEDYMEVLATFHPTGAPKESVYQGTWFRDRVPGADKESQQQAMRLPPDGEEANRIAARARTGQAAIESIDAQTQRMAPPPLYDLTELQRHANRLFGFSAQKTLDTAQALYERHKLISYPRTDSRHLSQDVARTLPRVVAAIAEPYRELLAPGTGERPLGRRFVDDAKVTDHHAIIPTVTSAANAQLAPDERKIYDLICRRLLSAWHEDHIWNVTTVITAIRNAAVIDRYHSSGSAVQQLGWKVLDLAPAKAKRAKSPGTADADRGEQELPPGLASGQPQDVLNAEALKKKTRAPKRFTEGTLLTAMETAGKTLDEKELSDAMKETGLGTPATRANIIEVLLKREYIVRNGKSLEATDKGVHLIEVVHPEVRSPIMTGQWEAYLHRIHRGNAQLDPFMHGIEEYVRDVVGKVGQVAPPPKAPQPLPPANPAPASAVPTTVAPTYTAGGSLVDLLNSAFGFASFRASQETVCKAVIDGRDVLLVMPTGAGKSLCYQLPAIARGGTTLVISPLIALMEDQVAKLKERNFAVERIHSGRDRAASRQACVDYLNGKLQFLFIAPERLRVSGFPEMLAKRKPSLIAIDEAHCISQWGHDFRPDYRMLGQYLPTLRPAPVIALTATATPIVQNDIAVQLELAQPAKFIQGFRRENLAIEVVELAPSQRSEFATELLQDESRRPAIVYTPTRAQSTTLAAELSQHFPCAAYHAGLDSEHRQRVQQQFLEGRIEVMVATIAFGMGIDKPDVRTVIHTALPGSLEAYYQEIGRAGRDGAPSRTILMHSYADRRTHDFFFERDYPDVSILDALFHRLRAEPVEKSALQRQLRTDADAFDKALEKLWIHGGALVDFAENVSRGHDHWRDSYIAQADQKQQQLNLMLRYAESSECRMAALVRHFGDLADSQKRCGVCDFCAPDECVGQRFRPATRAELATAQQVLASLRSAGARSTGKLHSEIHPNGDLARDAFEEVLGAMARAGLVRVDEAKFEKDGKSIPFRKAFLTPAGEALDENTPLELVLKDAAQAAGRTRKKPKAKVKAAAPAKRKRAANAPDLEDTLRKWRLAEAKRRGVPAFRIFSDQALAAIAANRPATAAELLAIPGMGISNVEKYGAQLYRLLAANEPRP
(738) DNA topoisomerase 1 [Candidatus Solibacter usitatus Ellin6076]
1
MPKALVIVESPAKAKTINKYLGKQYVVKASLGHIKDLPKRDLAVDVEHGFEPRYEIIEGKKKLMGELRSAAKGVDQIYLAADPDREGEAICFHLQEELRSKKDGPAFFRVMFNEITKKAVEKAFEKPLQVNTNLVDAQQARRVLDRLVGYKISPLLWDKVRRGLSAGRVQTVALRVIVEREREIRAFQKKEYWTVDVDLLARTAPVLSTRLIKANDETPELPNQQTTDSLVAQLSGVDYIVKSVATREKRRNPVAPFITSTLQQDSSRKLRFSVKRTMMLAQRLYEGIEIGRDGAVGLITYMRTDSTRTSDDAISDVRHYIGERYGAPFLPPAPNVYKSKKEAQDAHEAIRPTSMAYSPEVVEQYLPEDEMKLYRLIWNRFVASQMMPALFDQTTIDVSAKAANGVEYTFRATGSVPKFDGFLKVYQEGKDQTDEDDEELKHRLPLVTEGEVLRLEAIRPEQHFTEPPPRYNEATLVKRLEADGVGRPSTYATILSTIQEREYVNKEAGRFTPTELGMVVTDLLLESFDDIFDVKYTARMEEELDEIEEGKLDWRAAMSEFYGRFDKDLKHAEEHMTDIKRMEKPTDLICEKCGRPLVIKWGKHGSFIACTGYPDFSSKSIESDLEKVQKDIEVRRQRALKKIELSLEKLRAKYPDRTITWGQDGEFLVIPSAPKIPKPMDAALKKLEKEIAVKRSEDRGKIEARLEKLQARYPQMKGFYDLDLRDTAEGVALTVRRKEEFCTYTRELTVDLPDLEGADLSEQGEEESCENCGRPMVLKKGRFGTFFACSEYPDCKTTRQIGGTQKKDVPLDEKCPQCDNNLVMKYGRFGEFTACSNYPTCKYVKQKTIGVKCPECSEGDIIERRSKKGKTFYGCNRYPDCTFVAWGKPVAEKCPECGSPYMIEKFLKSGAFWQCPNAECKHQVEAPAPVEVTS
(978) DNA topoisomerase 1 [Zunongwangia profunda SM-A87]
1
MAKNLVIVESPAKAKTIEKFLGKDYKVASSFGHIADLPTKELGVDTEGDFSPKYIVSKDKKDVVRKLKGLAKDAETVWLASDEDREGEAIAWHLAEELKLKDDRTKRIVFHEITKSAILNAIENPRGINYNLVNAQQARRVLDRLVGYELSPVLWRKVKGGLSAGRVQSVSVRLIVEREREIEDFTPEASYRIDAEFANAEGKTFRAKLPKNFDTKEEAEAFLKDNLGADFKVVDLTKKPAKKSPAPPFTTSTLQQEASRKLYFSVSKTMTLAQRLYEAGHITYMRTDSVNLSDDARKGAHREILKAYGEEYAKSRQFKGKTKGAQEAHEAIRPTNFASHSVRADRDEQRLYELIWKRAIASQMSEAQLERTNVKIEANKHDKVFTANGEVLKFEGFLKVYLEGSDDEDSEEQNGMLPDMKVNEQLQNIFINATERFTRPPYRYTEASLVKKLEELGIGRPSTYAPTISTIQNRNYIEKGSVDGTEREYTQFTLENGKVSEKKLTETVGSDKGKLVPTAVGKVVNDFLVNHFSNILDYNFTAKVEQSFDDIAEGNEEWTKMMKDFYTDFHPHVQDVAKNADREVGERILGEDPETGKPVSVRLGKFGPMVQIGSVEDDEKPKFASLSPDQTLDTITYEEAMDLFQLPKELGEYKGEKVEVNNGRYGPYVRFGKKYVSLEKGEDPMSVDFDRAMELIKEKEKADAPIYEYEDKPVQKGVGRFGPYLKWNGIFINVNKKYDFDNLSDEDIVELIEDKKRKEREKIIHHWEDEGIRVEKARWGRSNVIKGKTKVELPKTVDATKITLEEAKDIIAKKAPKKKAAKKTTKKKTAAKKTTKKTTKKTSKK
(139) DNA topoisomerase 1 [Granulicella mallensis MP5ACTX8]
1
MAKNLVIVESPAKAKTIGKYLGSDYVVEASIGHIMDLPKNDIGVELKLRTFEPTLIVSPGKEKIVDRLKKLAAKSDAVFLAPDPDREGEAIAAHLKFQLLPSIKDKSKMRRVTFNEITKKAVKAAFEHTREVDENLVDAQQTRRVLDRLVGYQISPLLWDKVRRGLSAGRVQTVALRLIVEREREINAFNPVEYWNIDAVLAPEKNGQEFTARMVGVKGLPIRVSNGTDAEGKEQFLSNALPDKEAVDEVMSQLEKATWRVRSIEKKERRQNPRAPFTTSQLQQQAAGRLGFNVRRTMGVAQRLYEGIELGSEGTVGLITYMRTDSTRISPDAVKDIRDWVQKKFGANYLPAKENVYKSKKDAQDAHEAIRPTSISFVPDEVRKYLSDEQYRLYKLIWERAVTSQMTPAIFDQTTVDIEAKADVSYDFRTTGSILKFDGFLRFDEEAKKARAARDAKASAAAIAEEKKTAAASADGDSAAEASKDATSEESSSERRLPELKDGQNLEKIKLDPQQKFTQPPPRFNEASLVKTLEEKGIGRPSTYASIINTIQERDYVKKLAQKLVPTEIGMVVTELLVKNFPYIFETGYTAQLEGELDAVEEGSEKWTDLLKGFYGHFEKELKVAETQMEDIKRMELETQEICDKCGSPLVLKWGKFGSFYSCSAFTKAKPITVAQGPFKKDPKAAVKKVLDTFQFPMRVKAMNDDVAEFSEEVADKSALMESLQRAAALGKKQSVKLVVEPESCDFTKENFSAKPDLNSPEADGEQEDEFCDNCGRTMVLRNGPWGPFMACPGYNEDPPCKTIRKLTQKVQSKPPVVLEEPCPKCGKPLLQRDGQYGEFVACSGYPKCKYVKQELLDVPCPKCGGEVAVRKNKRGDLFYGCTRYPKCDFTSNQRLVNETCPKCDSAYLVEYANSEGTFLICPNNREALPKRRPRKGAKEEEAPTTPECSFEKKIGPPKLKEAPAELTKPDPEKTKTLVEAMA
(570) DNA topoisomerase 1 [Muricauda ruestringensis DSM 13258]
1
MPKNLVIVESPAKAKTIERFLGKEFQVESSFGHIADLPSKELGVDVENDFKPKYTVDKEKKALVKKLKDLAKKAETIWLASDEDREGEAISWHLAEELGLDKNKTKRIVFNSITKSAIQKAIENPRDINYNLVNAQQARRVLDRLVGYELSPVLWKKIKPGLSAGRVQSVAVRLIVEREREIEGFTPEASFRIRAEFKTNEGNAFAAKLNKTFPTKEAAESFLKENIGADFSVSDLAKKPAKKSPAAPFTTSTLQQEASRKLYFSVSRTMQVAQRLYEAGLITYMRTDSVNLSNEALSAAKSAILDNYGEKYSQTRNFTGKSKGAQEAHEAIRPTDMKLQSPQLERDQAKLYELIWKRTLASQMSDAQLERTNVKIKASTHNEEFSANGEVVKFDGFLKVYLEGTDDEDGEEQEGMLPAMNVGEPLQNVFISATERFSRPPYRYSEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTVEGAQRKYVQLVLEDGKVSDSQLTETVGSEKGKIVPTDIGMIVNDFLVTHFTQILDYNFTAQVEEDFDEIASGDEDWQEMMKNFYKDFHPNVLKVEETAERASGERVLGTDPKSGRQVSVRLGRFGPMVQIGTVDDEEKPQFASLLPEQSIGTITFEEAMTLFELPRQLGVYEGEEVEANVGRYGPYVRFGKKFISLAKGESAFDVDMDRAIELIKEKQKADAPIATYEGKDVTKGKGRFGPFIKWDGMFINVNKKYDFDNLTEGDIAELIEAKKKKEAEKVVQEWPEEKIRIEKARWGRHNIIKGKVKVEISKDVDATKVTLEEAQALLEKKSPKKKAKTKAKAKK
(1501) DNA topoisomerase [Acidobacterium sp. MP5ACTX9]
7
MRVFLAEKPSVAREIAQALGCTHKEQGFFRGKNDLVTWAIGHLVRFAEPGEMNPAWGKPWRREALPMLPKDGGWLLIPEPRTEDQFNVVARLFGDKRITQIVNATDAGREGEAIFRRIYALSGASKPVLRFWTSSLTEEAIASALSHLRPAADYDNLASAALTRAQLDWLIGMNHSRAATLHNSVTCSVGRVQTPTLAMIVRRHHEIAGFIKTFFYEVHADLGEFVARAVNSQQKHDFEIKAEAETILRDVPSDTLATVTLVEVKKNRKAPPQLHNLGELQKEANRRFGFPADRTLAIAQSLYESKAITYPRSSSRHLSEDMVDGLPAVLKALRLGEERASYVKQALHRAQHGPALSKRFVDGSKLSDHHAIIPTAKPAPASLSGDERKVYTIVAERFLAIFLPDKETEDTRIDLEIAKHPFRARGSRLIAPGWTVLTGNQDFENKAADAEDRQALPAVKKGDELEVVESELVTKERKPPSRYTDATLLAAMETAGREIDDDELREAMKGRGLGTEATRAAIIQRLLDLAYVIRDGKQFEPTGKGIALIAQVLPHLASPELTGDMEAKLNLVEAGQLDAAEILAEVSESLRHEIPAVFRSKPMQAPDAPRITAGKDELLCPKCKAGLVTKRSTPNASAPFYGCARFHDGCNFTINTVVAKKTLTETNIKDLCSPTRHHTTKIIKGFTSKAGKKFDAFLQLSSATDFKTEFVFPR
(357) DNA topoisomerase 1 [Acidobacterium sp. MP5ACTX9]
1
MSKSLVIVESPAKAKTINKYLGADYTVEASLGHIMDLPKSDIGVELLNRTFAPTLIVSPGKEKIVDRLKKLAAKADHIFLAPDPDREGEAIAAHLAMQLRPVIKAGADIRRVTFNEITQKAVKAAFLKARDVNENLVDAQQTRRVLDRLVGYQISPLLWDKVRRGLSAGRVQTVALRLIVEREREINAFVPVEYWTVDAVLQAEKTSFTARLTGIDGARITVPNGFDKDGKAQVLANALPDHATTDQVVADLANATFAVKTVEKKERKQNPKAPFTTSKLQQEAAGRLGFNVRRTMGVAQRLYEGIEIGGETVGLITYMRTDSTRVSDDAVAEARTYIGALGERYLPAKPNEYKKKNEAQDAHEAIRPTNVAYHPDEIRASLSDEQYKLYRLIWMRFVASQMMPAIFDQTTVEIGAKAARSYDFRVSGSVLKFDGFLKVYETAPAASTAEASDEDGEEEDKRLPALADGQGLVRQAIEHEQKFTDPPPRFNEASLVKTLEEKGIGRPSTYASIINTIQDRDYVKKIGNKFVPTEIGMVVTELLVKNFPYIFETGYTATLEGELDAVEAGTEKWTDLLDGFYSHLEKELAVAETTMEDIKRKEEATDEVCDNCGSPLILKWGKFGSFFACSAFSKAKAVTIAAAPWKKDPKAVLKKILGSFHFPMIVKAVTFDETNFSKEVADAKEFAEAVKSAAGKGKKITAEPVSCDFTKENFAAKPDLNAPGADEAPEEEFCDNCGRLMVLKNGPWGPFMSCPGYSDDPPCKTIRKLTQKVQSKPPITLDEPCPKCGKPLLQRDGAYGEFIACSGYPKCKYVKQELLDVKCPKDGGDLAVRKTKRGDVFYGCVNYPKCDFASNLKLVNETCPKCHSAYLLEYGNKEGTYLVCPNNREFLPKRRPKKGQPVEVPTTPECTYERLIGPPKTVEAEPEMAVSAA
(606) DNA topoisomerase 1 [Thermocrinis albus DSM 14484]
1
MMRLFLVESPTKAKTIQKYLGKDWKVLASMGHIKDLPEDELGVDLKTLEPRYVFVRGKRKVWDQIKRTAQKCESIYIGTDPDREGEAIAYFLWNLLKPLGKKLYRVRFYEVSKEAITLSVQKPEDSPNMNLVRAQMARRVLDRLIGYLLSPKLWVYLKNNRLSVGRVQSPALRLIVERERQIRQFKKKKFYYIKAVFEKNGHTFHLIWDYRFEKPENAKPYLEKLKSVPFEVERVVRGKVKKEPPKPFHTANLQAVASQKLGVGVDKVQKLAQKLYEEGFITYPRTDSLRMDEKKAQEFMNYIKKTLGEEYVGTLRKFKEKPTSQGAHECIRPVSLDRSPTGGVEEKLFTLIMKRTLASLASPALLEKTDVVVVPLCEPRMEFKGQWQRILFDGWLRIEEEELDLQEPPPLSEGEILLPKKVTLEERRTEPPPRYTEATLVKTLEKLGIGRPSTYAQIVKTLKDRGYVTEEKGVLKPTPLGEQVLDFLEKYYPRLVDYKFTAYMEEELDSVEEGKDWKTAVRYLFRAVAPEEELPSSTS
(1685) Reverse gyrase [Thermocrinis albus DSM 14484]
6
MIGAVFKNLCPNCGGDIGADRLQRGLPCERCMPQEGDPCHLLTEGQLRIWCDVEKKEEDWEKHFERCVGSKPWSLQKTWAKRVFMGHSFALLAPTGVGKTSFGLAMASFLAKEGKRSYIILPTRILVEQVVHKLQERFRLKEEDLLYFGDDSKKQKEEKRERLKEGRFKVLVTTSMFLYRNYQDIPSGFSFIFVDDVDSFLKTAKNVDKALYLLGFSEEDIDLAMRVIQLKTKRQKTDEDWEKIKEISQKLMEKRGEGVLVVSSATSNPRSNRVKLFRELLGFEVGTPTFYLRNVVDAYQEGTHNFLDWVKRLGGGGLLFVSSDKGKEEVDRVVNILRGEGISAVSYEELKEETLKDFEEGKIQLLVGIASYRNPLARGLDLPHVIRYALFLGVPKIVISLKFETNLSHLLWALSSIRSYIVKKLPQHMQKVDNWISQLRRYQYLTEEFVEERPDLKERLDQLRSQIGEFLSSEELVRIMSESEEITLRKTEEGYQLVVSDATGYLQASGRTSRMYAGGVTKGFSLIFVDDKKAFHHLVKKVRWFSDDINFLPVEGLDVEKIMEEVDADRSNVRAFMKGDVSVSSSDLLKPVLIVVESPNKARTIANFFGKAVRRRVGQHDLLETSVEDRYLMITASLGHVLDLVKEGGFHGVLMEKGVTPMYEVIEGKEYVVESLRRMASESMEVLIATDPDTEGEKIGWDLMQLLKPYNHSIRRMEFHEVTKKAILRALKEPRDINENLVKAQIVRRVSDRWVGFEFSQILQQAFGKSWLSAGRVQTPVLGWIIEREKEYRQKIYKVQVLIRDEKGRLKLELDFEDRKTAEAFFKELSYIEVTVKDQKEELRNPPPPFRTDTLLKEASDRYRFSLPKTMALAQTLFELGFITYHRTDSVRVSDYGMSIAREYIEEELGKEYVHTRQWGEGGAHECIRPTRPLEPEELRSMVLSGQVEGLTKEHILLYELIFRRFMASQTRAVKVKVKDVVIKALDRSVELSLVTDVLQDGWNKFLDLELNPDIPPRLDVRELKQMKKQPKAYLYTHGELVQEMKRRGIGRPSTYATIVEKLLERGYVIEKRGFLIPTKLGKKVYEYLRKREEIKAFLSEDFTRRLEEVMDRVEEGKADYEEVLKGLYRDIIKVEAIMEVTR
(1635) DNA topoisomerase 1 [Sulfurihydrogenibium sp. YO3AOP1]
1
MSEKKIVIVESPKKAKEISHFLGKDFIVKATVGHFKDLPENEMGVDLNTYEPKFVIKSQNHKKILSEIKKLAEKSEVIIATDPDREGYAIGFFMYEELKKKAKEVKRAEFHEITKEHIKEKIKNAVPFEKTNFGLFNAFLGRRVGDRIVGYTLSPIASREIGGRFSVGRVQSPAVRLIVEREIEIQNFKPTPYYVLSAVLRATSHVSPLTFTAIYENPKIENKEEAEKIYADIKDEKIATIKKVEKKQVKQSPKPPFTTSTLQQTASTVYRFAPEKTMMLAQDLFESGLITYHRTDSVRISEKAIDGIRNLINKEFGKDYLPEKIRVYKSKNTQADAHEAIRITHFVNLEEQKKLIKEKGLSEDHFKLLKLIYERTVASQMADAIFERTSAAVDIKGYTFKASGSILKFKGYKAVYDLEEEEDKEENQKLPDLKNKDVLTLEKINLEEKFTKPPARYTEGGLVKKLEELGIGRPSTYATIIKTIKERGYVVKENGSLRPTENAFHLIEYLNTRYNWVIDYSFTKKMEDFLDKVEENKKDWKEFVKQLHEKSGSKQNVKISKKMLDYAKDLAEKHGKSIEEIKDDPEKLKEFIDAHAEKNPSQKQIEYAKSLAEKTGLKLTEKELLDRKLLTKWINKAKKEMMKNYQLSEKQKNVLIKYGREDLVNNPVQALKFIKSKLSRYKK
(1572) Reverse gyrase [Sulfurihydrogenibium sp. YO3AOP1]
6
MIASIFKNLCPNCGGDITSERLYKGLPCDRCLPQEPKEEVCDVLKKGKFKILCDIDDEVSNWQNFFSKHIGSHPWSLQITWAKRFFLNCSFALLAPTGIGKTSFGLSVASYLTQKNKKSYIILPTKLLVNQTVKKLTQIFKLKEDQILFFGEENKKEKEAKLERLKDGDFSVLITTSMFLYKNHDKIPKDFSLVFVDDVDSFLKTAKNIDKALYLLGFDEKDINLALEVIKLKAKQNKTDEDWNKINQLTEKLRKIEAKRKGVLIVSSATSNPKSNRIKLFRELLGFEVGTPTFYLRNIVDSYDDIENHELSELIKKLGKGGLVFIPSDKKKEYVEEVKEYLTKKGVKAATYEEIDDEILKKYENGKIDVLIGISSYRNPLARGIDLPHVIRYAIFYGVPKIVLSLKFEANLSHLLWALSSIRAYILKKFPQYAIQIDKWITQLKKYQYLTEEFLQNNPNLKEKVDNLRLEVGQFLNSEEIINLLKESNEVTLRKDEDGYKLVVSDVTGYLQASGRTSRMYSGGITKGLSVILIDDKKAFNHLQKRVRWFSDDIEFVDFKSIDLAKILKEIDSDREKVRKILKGEIKFEKVESILKPVLIVVESPNKARTIANFFGKAVRRRVNDHEILETSIDDRYLMITASLGHILDLNKELGYYGVFVKDHIVPVYESIEGKEEIIESIRSVSFESLEVYVASDPDTEGEKIGWDVELLLKPYVKNIQRMEFHEVTKKAIINAIKNPRDFDENLVKAQIVRRVADRWVGFEYSQLLQKAFGKNWLSAGRVQTPVLGWIIEREKERKQKIYRITITLQQDSKKLELDIDYQNKQDAENIFNNLNNIEIIVKEVKEEDKNPLPPYRTDTMLKDASDRYRFSLPKTMELAQDLFELGYITYHRTDSTRVSDVGIALAREYIEEAFGKDYFQARVWGEGGAHECIRPTRAMETEELKSMILSGQYEGLTFDHIKLYDLIFKRFIASQMRAVKFKAKDVIIKGFGFELEKVLHTDIIQDGWNKILPAELHPDLEGIIDISNNKQFKIMPKAFPFTHGELVFRMKERGIGRPSTYATIIAKLLERKYVIEKKGLLFPTSMGIKVYQYLNSLKHVREFLSEEFTRKLEELMDEVEIGEKDYQAILFELFEKIKIRRDN
(759) DNA topoisomerase 1 [Persephonella marina EX-H1]
1
MGDKKTKKIVIVESPKKAREIQKFLGKEYSVKATIGHFKDLPEKEMGVDLKTFKPKFVIKSKNHRKMLSEVKKLAENAEVYIATDPDREGYAIGYFMYEELKKKAKDIKRAEFHEITEKHVKDIIKKAPKFEQTNFGLFDAFLGRRVGDRIVGYTLSPIASKEIGGRFSVGRVQSPAVRLIVEREREIQQFKPTPYYVLTAILKKDDTQFVSYYEKQRLEDKELAKKIYEGIKTVRQAVVKDIKKKEVKQSPKPPFTTSSLQQTANSQLRFAPEKTMMLAQDLFENGLITYHRTDSVRISKEALTGIRKFIEKSFGKEYLPSKTRVYRSKNTQADAHEAIRITNFVDLDTQRKLVSEKGLTEDHFKLLKLIYQRTIASQMKDAVYDRTTALFDIGGYVFKTTGSVLKFDGYKKVYNIEDKEETQRLPDLKKGETVEKVDQKLEEKWTKPPGRYTEGSLVRKLEELGIGRPSTYATIIKTIKDRGYVVKEGGSLRPTEAAYHLIDYLNGKYNWVIDYDFTRRMEEFLDAVEEKKKDWKEFVEELYRKSVEGAKNVISKKMKDYALDLAKKHGKDISDIIDDPEKLKEFIDQHKETKPSEKQIAYARSLSEKTGLELPEDVLQDKEKIKRWINKAKKEAMKSYKLSEKQKAVLIKNGKEDLIDKPEKALKWLEMYFRKRRKK
(406) Reverse gyrase [Persephonella marina EX-H1]
6
MSAIPIVYKDICPNCGGEITAERLEKGLLCESCLPEEIPREDICGILGYGRFVSICELWDKVNDFKSYFKGIINNDLWSIQETWTKRFFLNISYALLAPTGIGKTTFGLVLSKYLSEKEGKKTYLIFPTQVLVNQAYDRLVSFGMDPEKLLAYSTKFAKTKKKQEELKEKIKNNQFDILITTTMFLYKNIDIIPKGEFSLVFVDDVDSVLKSAKNIDKILMLLGFSEEDIQDTLKFITFKQKIFRQGQPEEKDLEIFNRWQEKINRISQKRKGVLIVSSATSNPRSKRVNLFRELLGFEVGRPSLTLRNIEDLYEKPDDVWETSVERIKKLGSGGLVFLSSSETRETLERYVKFLNEKGINAISYEDLMDSLEKFRSGEIPVVVGFASYRNPIARGLDLPDVIRYALFVGVPKLQFNIRFEEEFIHLYYFMLTLTPFLIKKKLIDPQEVRQLYEYINFLKVYAFIPEEKLDREKAERLREIQVYVKSIVEKPEVFDQIKDSPEITLKKTDEGFILITADVTGYIQASGRTSRLYAGGLTKGLAYLLVDDDKAFYSLQKKVRWFSEDIQFKPADQVDLEKILKEIDQDRENVRKVLSGEIIVEERQSFKTTVVIVESPNKARTIANFFGKPLRRKLKGIDAYEIAIGDKFLTIIASKGHIFDLNKEEEYFGVRKNSHFIPVFEPIDEGRKHIIEGIRELDLEVQEVFIATDPDTEGEKISYDLYLLSKPYNFNVKRAEFHEVTKKAFLEAVENYRDIDKNLVKAQLLRRISDRWIGFTISQYVQEKLHRHYLSAGRVQTPVLEWIIERTDQAKQKIAVVRVFIDNIPVEFSFEDRNRAKWFYQNIQFVIVSVKEKKEEKLFVRPFSTDTMLTASARELGFSPQETMSLAQDLFEAGLITYHRTDSIRVSDAGVFVAKEYIQENFGSEYIKIRTYSTYEGAHECIRPTRAVDADELRSMVYTMNLQGITRKHIRLYDLIFRQFIASQMREAVVEKVVYSVRAFDEEVETDLITDIIQHGYDLILPIRTDKLPEGKVDIKKKSYHLKPKVSYYTFGEIIKEMKEKGIGRPSTYAITVQKLLDRHYIIERRGYLFPTKLGRQVMELIKRREDIYRFVNESFTKELESLMDRIEQGKADYEKELEKLFKELEEKKLFFKVEIGKYSYEE
(502) DNA topoisomerase 1 [Sulfurihydrogenibium azorense Az-Fu1]
1
MKKVLIVESPKKAKEISHYLGKDFIVKATVGHFKDLPEDEMGVDLQTYQPKFVIKSSNHKKILSEIKKLSQDAEVYIATDPDREGYAIGYFMWEELKKKAKTVKRAEFHEITKDHIVEKIKEAVDFEKTNFGLFNAFLGRRVGDRIVGYTLSPIASREIGGRFSVGRVQSPAVRLIVEREREILNFKPTPYYVLTALLEKDGIKFTALYEKQKIEDKQEAEKIYQDIKDEKTAAVEKVEKKQIKQSPKPPFTTSTLQQSANSVYRFPPEKTMMLAQDLFESGLITYHRTDSTRLSDQAITGIRKLIEKEFGKEYLPKNPRVYKSKNTQADAHEAIRITNFVPLKDQEALVKEKGLSEDHFKLLKLIYERTVACQMEDAVFERTNITLKIKNHTFKASGSILKFKGYKAVYDLEEDDEESQSLPKIEKNQLINIQSINLEEKFTKPPARYTEGSLVKKLEELGIGRPSTYATIIKTIKERGYVVKEGSSLKPTDLAFHLVDYLNQKYNWVIDYNFTKKMEEFLDKVEENKKDWKEFVKHLHQKSVSTTRSKVSKKMLDYAKDLAKKHGKDIDAILDDPQKLKEFINDHADKKPSEKQITYAKSLSEKTGLPLTEKELSDKKLLTKWINKAKKEALKNYQLSEKQKNVLIKYGREDLIEKPAEALKFIASKLKRFKK
(999) Reverse gyrase [Sulfurihydrogenibium azorense Az-Fu1]
6
MIYAIFEKLCPNCHGEISSYRLEKGLPCKKCLPDEDLDVCQHVKPGDIKQLCHLQDTLQTWQEHFQTYIKSKPWNLQNTWAKRVFLKHSFVLLAPTGIGKTSFGISMASFLAKQGKKSYILLPTKLLVKQVYEKVKNFGVDKKDILAIGLEKSNKEKEENKERLKNADFKILITTSMFLYKNFEIYPRDFEFIFVDDVDSFVKTAKNIDKALYLLGFTQEDIEKALILIKLKAKPNKTQEDWDKINQLTEYLQKQRKKITGVLIVSSATSKPRSNRVKLFRELLGFEISSPTFYLRNIVDSYDEEYSFEKLLYWINKLGKGGLVFIPSDKGKEFVDEVVEKLNKHKIKAVSYEELDDKNLKKFEEGKIQVLVGISSYRNPLARGLDLPHVIRYALFYGVPKISISLKLEENLSHMLWALTSIRSYVIKKFPEITIKINQWITQLQKYQNLTLDFIQNNPQLKEKIENLQKEIRDFFQRPEVLEVLKSSDEIVLKQKEDGYYLIVSDATGYLQASGRTSRLYAGGITKGLSLILIDEKSAFKHLNKRVKWFSEEIEFVNINQVNLDQLIKQIDEDREKVRNFLTNSTKTISSSDLLKPTLIIVESPTKAKTIANFFGKPVRRKINQTEVLETSTEGRYLMITASLGHILDLVKNIAYHGVIVEDKEIIPIYETIEGKEETVENLRRLAIENMEILLGTDPDAEGEKISWDLQDLLKPILKNIKRIEFHEVTKKAITKAINDPRDINENLVKAQIVRRVADRWVGFEYSQLLQKEFQKNWLSAGRVQTPVLGWIIKRQQEASKKIYVINVSIPVEDKKFSFEITFETKEEAEKFYQNLKEVEVVVEKRYEEVENPPPPYRTDTLLKDASDKFRFTLPQTMDLAQTLFELGYITYHRTDSIRVSDAGIYLAKEIITQEFGENYFKPRVWGEGGAHECIRPTKNITPEDLESLMLSKQIEGLSYNHIKLYKLIFNRFIASQMIPVKVEMADIVIKALNFEIKETIKTKVLQDGWNLVLGIETRPLIEGKIDVQEYKNLLQRPKAYLYTHGEIVKEMKEKGIGRPSTYATIIAKLLERGYVIERKGFLIPTNLGKTVYNFLTNKPNLKEFLSEEFTRKLEEIMDKVEEGKEDYITVLKDLFVKVRKIS
(392) Reverse gyrase [Thermovibrio ammonificans HB-1]
6
MKVAEFHRMCPNCGRIISDKRLKAGLPCERCLPEFLKWKEREEICEAIEELQNFQQICRLDRFVKEFTEFFKEKTGFTPWSLQIMWAKRVALKKSFTMIAPTGVGKTTWGLVTSAFVKGKVYVLVPTKLLVLQTVERLKKLTDKKVVAYTGKKREKETIASGEFEILVTTTNFLYRNFEIIPKPFDFVFVDDVDSLLKSAKNVDKVIMLLGFTEEDVELAMKVIDLKAKAAKSSGRELQKLLERIKRLEKHLERRREEIDRVLVVSSATSQPRSKRVKLFRELLGFEVGKSATALRNVEDVLIFTEKDELQLAVETVKKFGKGVFLFVSADRGREYVDRVVETLNSNGIPAVSYEEFTPENQQRFVNGEIWAAVGISSYRNPLARGIDLPQAVRYALFLGVPKMEFGVKLSLSPVKLFGLLLVLRELFSEEELPKVNGYISYLKRYLTLKEELLDRYPKIKSRLQEIKEFLEAHLSNPEFLKKIRESETVSLKEKNGELVLVVGDAAGYVQASGRTSRMFAGGLTKGVSLMVVDDVKALNSLRKRVMLFLEDVEFKVLETDKGKEFAGKLGLPTITEEELKAVFKQVDRDRKRVREILEGKVTPETKSLVTTALVVVESPNKARTIANFFGKPVRRRVKDVDAYEINIGNKLLLLAASKGHVFDLTVRDGVWGVKEEDGHYIPVYDTIKYCTKCNEQTTENFCTKCEGRPDVDKITVVEALRELGLEIDEVYIASDPDTEGEKIGWDVGCNLKPYQMNMKRMEFHEITKWAFLKALEEPREIDENLVKAQIVRRVADRWVGFSLSQHLWKVFNRRWLSAGRVQTPVLGWVIERFEESKEKIGLLTVECEGVSFTFKLEEPQKLKEVKADKVKVKVREVSVTEKNPKPPFNTGELLKEAADRLKLSAERVMEVAQELFESGFITYHRTDSTRVSTAGMGVAKEFITERFGPQFVKLRPWGEGGAHECIRPTRPLDAEGLRTLVTVSGSTVKMERDHYAVYDLIFRRFIASQMVPAEVERVKAEVKLLPDELQKEEEFTTKITKDGWNLILPQIEVTELPFEPTEGESYYLPVKAVHKRLIPKVLPYTQGELVEEMRKRRIGRPSTYAKIVQTLLDRKYVVERRHRLYPTKLGIEVYNYLAENFPHYTSEEFTRELEELMDKVERGEADYQKIIEELKPVLQFANVDPKQTVGE
(1237) DNA topoisomerase 1 [Thermovibrio ammonificans HB-1]
1
MGKKLIIVESPAKAKTIQKYLGKDFIVKASMGHVIDLPEKEFGVDIEKGFKPKYTTIKGKEKVLKEIKEAAKKSDEVYLATDPDREGEAISWHIANALKRVKKDNIYRIRFHEITKRAIQEAVKNPDTIDEKKVNAQQARRILDRIVGYTISPLLSRRFKRALSAGRVQSVALRLICDREEEIRKFVPKEYWTVEAKFAKGSEELPAKLWKVDGKRLEKFDIPNEKAAKELVERAKGAAFSVAKVERKERRRKPPAPFITSTLQQEASRRFGFPAKVTMQIAQELYEGIDLGSERVGLITYMRTDSTRVSDEAVKEVREFIKEHFGQNYLPKTKRSYETKKPKSAQDAHEAIRPTSVFRTPESVKPYLTPEQFKLYDLIWRRFVASQMKDAVFNTVSVDVEGGGLTFRSTGSTLKEEGFLKVYPVEVEEKLLPELNKGEALELKEVKGVQHFTEPPPRYTEGTLVKALEEEGVGRPSTYATIISNIIQRGYVAKEKQKLKPTELGEFINSLLKKLFPKIVDVKFTANVEEELDKIEEGQKEWKELLKEFYFGEFKELLDRAEKELKQIKGEEIGRECPRCGAPLVKIHGRYGAFIACSAYPECTYKESIKEEPQKLDRKCPECGGELVIKNGKFGRFIACSNYPECKHTEPLTFGKCPKCGEGEVVERRSKKGKRFYGCSRYPDCDFVSSKPPKGGES
(1528) DNA topoisomerase 1 [Desulfurobacterium thermolithotrophum DSM 11699]
1
MGKKKLLIVESPAKAKTIQRYLGKDFIVKASMGHVIDLPEKEFGVDIEKDFKPKYVTIKGKDKVLKEIRKAAKESEEVLLATDPDREGEAISWHIANALKRIKKEGIYRVRFHEITKKAIEEAIKNPDKIDENKVNAQQARRILDRIVGYTISPLLSKKFKKALSAGRVQSVALRLICDREEEIRKFVPKEYWTVEGIFRKETSKFPAKLFAVDGKKLDKFDIPDKNSANQLIDRAKKAVFVVTRVERKERKRKPYPPFITSTLQQEASKRFGFPAKLTMQIAQQLYEGIDLGKERVGLITYMRTDSTRVSDEAVKEVRNFIEENFGLEYLPKTKRSYETKTPKSAQDAHEAIRPTSVFRTPESVKKYLTSEQYKLYELIWKRFVASQMKDAVFNTVSADIEGNGLLFRATGSTLKEEGFLKVYPVEFEEKLLPDLNEGDKVEQEDIKGIQHFTEPPPRYTEGTLVKALEEEGVGRPSTYATIISNIIQRGYVEKEKQKLKPTELGEFINDILKKLFPKIVDVKFTANIEEELDKIEEGKKEWIELLKEFYFGEFKELLEKAERELKSLKGEEIGRECPKCGAPLLKIHGKYGTFIACSKYPECKYKESLKGEPKKTGEICPKCGGELVIKNGKYGKFIACANYPKCKYTAPLTYGKCPKCKEGDIVERRSKKGKKFFGCSRYPECDFISNKPPSEAKK
(293) Reverse gyrase [Desulfurobacterium thermolithotrophum DSM 11699]
6
MKLAEFHRMCPNCGGIISDERLKAGLPCEKCLPKELFYTNRKEICNALGNKLQDFKKICLLDEFTENYVKFFKEKTGFTPWTLQVMWARRVALSKSFTMIAPTGVGKTTWGLVTSAYLSGKVYILVPTKLLVLQTVEKLSKLTNKKIVAYTGKKSEKGTIQSGNFEILVTTTNFLYRNFEIIPKPFDFVFVDDVDSLLKSAKNVDKVIRLLGFTEEDISIAEKVLELKSLVAKFGEKVDRKLIEKLKKLENFLEKRKSEIKNVLVVSSATSQPKSKRVKLFRELLGFEVGKSATALRNVEDVLIYTDKDYLEETVKIIKKYGKGVFVFISEDLGKDYVEEVVNFLNKKGISTVSYENFSSENQGNFIDGKIQAVVGIASYRNPLARGIDLPQAVRYAVFLGVPKLEFNLKLSLAPVKLFGILLVLRELIEDKTKVMSYLSYLKKYLSLKKELLDKYPKVKEKLEEIKGFLESYLSNKEFLEKVRASEDISLKEKNGELFVVVGDATGYVQASGRTSRMFAGGLTKGVSLMLVDDLKALNSLKKRLSIFLEDLNFKVLDYDKGKELAEKFGFELIDEEKLNKIFKTVDEDRKRVKEILEGKIKAETKNLVNTALIVVESPNKARTIANFFGKPVRRKVLDIDVYEINIGDRLLLLTASKGHVFDLTVRDGLWGVKEEESSYIPVYDTIKYCTKCFEQTTEPFCSKCSGKPDVDKITVVRALREVGLEIDEVYIASDPDTEGEKIGWDIGTVIKPFQKKVRRMEFHEVTKWAFMEALKTPKEIDENLVKAQIVRRIADRWVGFALSQHLWKVFKKHWLSAGRVQTPVLGWVIKRYEESKEKKGIIVVETKAGSFRFEFDNLEEFQKIAIDKVEIKVKEKSIFEKNSLPPFNTGELLKEASNNLGISAEETMNIAQALFESGFITYHRTDSTRVSTAGMGVAKEYISQKFGAEFIKLRSWGDGGAHECIRPTRPLDAESLKALVLVSGSSSKMTKNHFRIYDLIFKRFMASQMIPTKVEKCKLLVKLLPVEKEEEEERIAKIVKNGWNLIQPLNLEPLSVELKKEKTYYFEIISYVKKKVPKVFPYTQGELIEEMRKKEIGRPSTYAKIVQTLLDRKYIIEKGKFLYPTKLGIEVYNYLSEKFPDYTSEEFTRELENIMDKVERGEEDYQKVIENLKPILEIRYS
(360) DNA topoisomerase 1 [Thermotoga lettingae TMO]
1
MANKIIIVESPAKAKTIKEILKGEYDVLSSKGHVRDLPEKEFGVNIEKDFEPTFKIIYGKEKIVQELKKKAKNKQVLLGSDMDREGEAIAWHLADILGVANEKNRIIFNEITPQAIKNAVKEPRNIDMNKVHAQLARRILDRIVGYKISPLLWKMLKTSSSAGRVQSAALKIVCEREIQRHKFQPKKFWKVQGYIGSLKFYLTHIDGKKIDMQQIDEKLAKEIEKNVKVLKVIQIKTRKIQKKAPSPFITSTLQQEAANKLGFSVKKTMQIAQQLYEGIDTPKGHRAFITYMRTDSTRVSEIAKQKAIEFITDKFGKNYLGKKVRTEKAKQNVQDAHEAIRPVNIDLTPDQVEGDLGKDQYRLYKLIWERFMASQMADAIYEETTIQFQSDRYTFESKIERRIFDGFEIILKKDKEQEITIPSGEIRISKWQIEEDETKPPARYTEASMVRALEIRGIGRPSTYATIISTLLERKYVIKSSNQLIPTVMGFVVNHYLEKKFPEIVDLQFTAKMEEALDKIEQGQKDYKELLRDFYNDFSKYLDEAQQKWLSIDMNTNLECDCKSKYKLKVGRYGLYLLCENCSKTTSLALETPAVFYENTMYFTHQEKESIETVCPVCGGKLEQMSGRYGNYIKCQNCGKTYTGFARGKCPKCSAVVEKKISKNKRIFFKCTSDNCDFISWLEPSNETCPECSQRLYYKKYRSKEVLYCQNCKKTFQLKTKK
(1745) DNA topoisomerase 1 [Thermotoga petrophila RKU-1]
1
MNRKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGIDLEKDFEPEFVVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGKKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKTNLSAGRVQSATLKLVCDREREILRFVPKKYHKITVKFDGLTAEIDVKEKKFFDSETLKEIKSIDELVVEEKEVSLKNFSPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKDEARNLITEVFGEDYVGAKGAKRKGNTKIQDAHEAIRPTNVFMTPEEAGKYLNPDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWTTERNTGEFPFEEGESVKPVVVEIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTVVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLQEFYQSFSSVFDRNDRIVIDFPTNQKCSCGKEMRLSFGKYGFYLKCECGSTRSVRNDEIAVIDDGKIFLGRKDSESGSPDGRSIKGKRNLPEKRRKGKKSS
(246) Reverse gyrase [Thermotoga petrophila RKU-1]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEESPSDIYGALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIIQGKSFTMVAPTGVGKTTFGMMTALWLAEKGRKSALIFPTVALVKQTLERLQKFSDGKVKILGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIKKAFSAIKQGRIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISTRSKEKLIELLEIFRDGILIFTQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKLNILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLEFDRAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLEMTIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEESETNWKELVHEVEESRKRIEGELTDTSKSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVVLFTATRGHVYDLVTRGGIHGVEEEDGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPATRSLRRIEMHEITRYGFKKARENVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEVEEERNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLKKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMVEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIATVELNGKRLGIEQIIEVLKNGWNLFVPLTVSPRFEHRNYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRLGVKVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(1141) DNA topoisomerase 1 [Thermotoga naphthophila RKU-10]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKNKFGVDLEKDFEPEFVVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGKKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKTNLSAGRVQSATLKLVCDREREILRFVPKKYHKITVKFDGLTAEIDVKEKKFFDSETLKEIKSIDELVVEEKEVSLKNFSPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKDEARNLITEVFGEDYVGAKGAKRKGNTKIQDAHEAIRPTNVFMTPEEAGKYLNPDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWTTERNTGEFPFEEGESVKPVVVEIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTVVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLQEFYQSFSSVFDRNDRIVIDFPTNQKCSCGKEMRLSFGKYGFYLKCECGSTRSVRNDEIAVIDDGKIFLGRKDSESGSPDGRSIKGKRNLPEKRRKG
(1233) Reverse gyrase [Thermotoga naphthophila RKU-10]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLLEESPSDIYRALLERKTLKEYRFYHDFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLAGKGKKSALIFPTVTLVKQTLERLQEFADEKVKILGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIKKAFSAIKQGRIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVERLVSVARNITHVRISTRSKEKLIELLEIFRDGILIFTQTEEEGKELYEYLRRFKFNVGETWSEFEKNFEDFKSGKLNVLIGVQAYYGKLTRGVDLPERIKYAIFWGTPSMRFSLELDRVPRFVLARVLKEMGLIKVQENPDVEGLRKMAKERLSQEEFVEKVKEIFRGAVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEESEANWKELIHEVEESRKRIEGELSDKSKSLLIIVESPTKAETISRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEEDGKFVPVYNSLKRCRDCGYQFTEDRNECPVCSSKNIDDKTETLSALREISLEVDEILVATDPDVEGEKISWDVTQYLLPATRSLRRIEMHEITRHGFKKARENVRFVDFDLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLLLENGVNLEVEGKITDDVVAVVELKEVEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLKKIGKEDIFTGRSWSTEGAHEAIRPVKPIDARELEEMLEEGLITDLTKKHLRVYELIFNRFLASQSAAVKVRKQIVTVDVDGNRVGIEQIIEVLKNGWDFFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFSQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDRYKRVRPTRLGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(779) DNA topoisomerase 1 [Dehalogenimonas lykanthroporepellens BL-DC-9]
1
MKKHKKLVIVESPAKARTLARFLGSNYSLKASLGHVRDLPKSTLGVDIENDFKPKYINMRAKSAVIKDLKEAVKKSDEVVLATDPDREGEAIAWHLVEAIGLGATPYRRVVFHEITKDAIDKAFKAPRDLNMDLINAQQARRVLDRLVGYKLSPLLWRKVRRGLSAGRVQSVALRIIVDREREIESFIAVEYWTIEGEFSPKNKPGEKFKAGLIGVGGKKKISIPDAETAEIIVLDLKTAEHKVDSITEKPASRRPSPPFITSTLQQEAWRKLKFSAKQTMALAQQLYEGLSVGEEGNVGLITYMRTDSTHIAQSALADTRKFIGEQYGEAYLPKTARHYSKKIKGAQEAHEAIRPTDVKRTPERLKPYLEPNQLKLYRLIWQRMVTSQMADARFLNTTVDIVSFGTKSKEKYIFRTQSSLNVFDGFMVLYTEGKDDDIEQNTAKIPDLKDGEALNLTDIVKDQKFTQPPPRYTEATLIKTLEQFGIGRPSTYAPILSVVQQRDYVEKTKGVFKPTELGMIIRDILVQQFPEVIDAGFTAQMEESLDKVAEEGYNWVTVINDFYTPFNNDLEAAQAQLEKVPLPVEESEETCPKCHQAKLLIKIGRYGKYMECPDCQFRQSFRIRTGVMCPDCPENAEIIGRYSKKGKLFYGCEAFPKHKFAINARPVAVPCPECGGLQAEYNNKRIKCTNKTCKNAK
(66) DNA topoisomerase 1 [Dehalococcoides mccartyi BAV1]
1
MKEKLVIVESPAKARTISKMLGKDFNIMATMGHIRDLPKSTLGVDVENNFTPKYVSLKAKAKVIKELKEAVKHSKAIYLATDPDREGEAIAWHISEVTKANLSNPKRVVFHEITKEAIDKAFKNTRELDMDLVNAQQARRVLDRLVGYKLSPLLWRKVQRGLSAGRVQSVSLKIIVDREREIEKFVSTEYWNIEALLSKKVKSAAFKATLAGYVTKGKLEIHNESEADQIKKELEVSDYQVLKIKRKSNLRQSPAPFITSTLQQEAWRKLRFSAKQTMVIAQQLYEGLNVEGEGEVGLITYMRTDSTNVARTAVAETRDYITEKYGPAYLPKQARVFSSKVKGAQEAHEAIRPTRINRTPDFIKKSLSADQFKLYQLIWQRMMASQMSPAVFDNTTIDIEAKHQPSKTRYLLRTTSSVNTFPGFTIVYIEGKDEDEEKEQSSLPPMEEGEELKLKSLDATQHFTQPPPRYTEATLIKALEQNGIGRPSTYAPTISTIQEREYITKLKGSLKPSELGMLVNDLLVEHFPDIIGIDFTAAMEAELDKIATEKLDWVPIIRRFYEPFIKEIEAASEKIEKIKPPEEELDELCPECNAKLVIKRGRFGKFIACSRYSKEDDGCRYTRSYQIKTGAKCPDCNSDIVEKYSKKGKIFYGCAGYPNCKFVSFYKPLTKPCPECGALMTKSGQNWAKCTKCGKRKKLEDES
(672) DNA topoisomerase 1 [Gemmatimonas aurantiaca T-27]
1
MAKSPARKTPVSKTAVRKTAAGKTTARKAAARAEAIDLPEDDEPAPAGGTSLVIVESPAKAKTIGKYLGRGYTVKATVGHVRDLPAKKLGIDIDHGFAPEYVTIEGKEDILTDLKKVAKGAREIFIATDPDREGEAIGWHVEQYFTQPKRHAVSAPIRRVMFHEITKDAVHKSMAKPMDIDNKKVEAQQARRVLDRLVGYKASPVLWKTVKKGLSAGRVQTVALRLIVEREREIRAFTPVEYWSIAADLQKGQQPFTAKLHQLDGKKPEIGNGTEAERIIADLAGRKEFVVTEVKRRERRKNPAAPFTTSTLQQEAAKKLGFGSKRTMRLAQDLYEGIDVGIDGATGLITYMRTDSTRVSEDAANSARESLRAQFGDDFLAPAPQLYPSGKANAQDAHEGVRPTDPSRRPEQVQKFLTADQFKLYQLIWQRFMASQMAPAVFDTTTVDFNIPIKVADAERNYLFRATGSVVKFQGFLALYREAREEGDAKALEDEQALPVLEVDERVPVKAITPTQHFTEPPPRFSEASLVKELERAGIGRPSTYASIISVLVERRYVSLEQRRFFPTSLGETVEKVMVKKFPDVFNVGFTAQMEEELDKIAEGEIDWVRALGDFWTPFQRTLNDNDLDALIGEAYDLSALETERCPDCGGKLVAKGGFFGPFVACENHPKACKYTRPIKGEKKPAELTNYMCQECGAPMVIRHGRSGDFLGCSKFPKCRGTRSMPTGVKCPKDGGEIAERRSKKRGKAFYGCENYPNCDFVVWDKPVAETCPECGYVGAEAKSNKTRGSFRKCLKCSNEWDVAAPDEAAEVAEVA
(1423) DNA topoisomerase 1 [Rhodothermus marinus DSM 4252]
8
MKRLVVVESPTKARTIRNFLPKDGFRVEASMGHIRDLPASAAEVPAHLKHEEWARLGVRIDRDFEPLYVIPRDKRKVVQQLKEALKEADELYIATDEDREGESIGWHLVEVLKPKVPVRRMVFHEITREAIEQALRNPRDIDHNLVEAQEARRILDRLVGYLVSPVLWRKIAPRLSAGRVQSAAVRLLVLREKERIAFVPATYWDLKALLEQAGQTFEAVLTHVGGIRVAGGKDFDEHTGRLKEGLVAGRDVILLDEAQARELAERLRHEGWVVADVEERVVTRSPAPPFITSTLQQEASRKLGLSARQTMQIAQRLYEQGYITYMRTDSTHLSQEAIEASRRTIVERYGKEYLSPQPRQYQSRVRNAQEAHEAIRPAGRAMKTAEELGLTGIDAALYDLIWKRTVASQMADARLRLLTVHLEAGDREPIARFRASGRTVEFPGFFRAYVEGSDDPEAALEDRDQPLPPLKKGDRPRCVQVESRRHETRPPARYTEATLVKTLEQEGIGRPSTYATIIDTILQRGYAVRRGNQLVPTFMAFATNNLLEACFEKLVDLGFTAQMEEALDEIAQGRQKTVPYLRQFYQGEEGLERMIDEALRRVDPREVSTIRFPQWEPYVVRVGKYGPYVEGPVDGQIVTASLPPDLAPGDVTREKLEQILREGQIEDRVLGIDPETGMPVLLRRGPYGYYVQLGDDEQAGKPKRVALPPGMEPAVVDLETARALLQLPRTLGTHPETGQPVLVGIGRYGPYVQHGRTFASLKEEDDVFTIDLERALELLAEKEARSRPLRVLGTHPETGEPVEVWEGRYGPYVKHGRTNASLPEGRAPEAITLEEALALLEEKASRKEKTRGRRRRSK
(684) DNA topoisomerase 1 [Roseiflexus castenholzii DSM 13941]
1
MGEKLVIVESPAKARTIQKYLGSGYRVEASMGHVRDLPKSNLGVDLEANFAPVYEISPGKEKIIAALRKSIRQADAVYLATDPDREGEAIAWHITEAAKIPRDKPVYRVVFTEITPGAVRSAMASPRDIDRRLVDAQQARRVLDRLVGYKLSPLLWEKVRRGLSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQNASDSQRDAFRAMLIERSGKKLEKFDIGASDQAQAIIADLEGAAYIVRKVTRRDKRRSPAPPFTTSTLQQEAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARRVIRERFGEAYLPAKPPVYKTKAKGAQEAHEAIRPTLSRRTPEQVQPYLTSDQYRLYDLIWKRFVASQMEAAVFDSTVVDIGAGRDIGGRGAGSDPYTFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPLLEEGEALNLLQLLPVQHFTEPPPRFTEASLVKELERLGIGRPSTYAPTISTIIEREYVELADKKLVPTTLGRVVTDLLVEHFPSIVDYGFTSEMEQQLDDIAEGEKEWAPVLRAFYRPFEQKLAEAQRSMRNVKREEILTDLTCPRCNQGQLAVKFGRNGEFLACNRYPECDFTSDFHRDSDGRIVLDAPASPETSDVLCDVCGRPMILKKSRFGPFLGCSGYPECKNTRRLDKQGKPAPLPKATGVTCPKCGQGELLERRGKFGRPFFGCNRYPKCDYLVNSLDEVAHYTPDANEASKPQAEEPTATDAKATPARKRVKTDANGAAAAGKRVKTDANGAVAGEPMKTKASANGKRAKTGTNGAAAAPPKKRGTER
(182) DNA topoisomerase 1 [Mobiluncus curtisii ATCC 43063]
8
MAEANQKLVIVESPAKARTIGKFLGEDFDVEASVGHIRDLAQPSDLPATLKKTGYAKFAVDLDHDFEPYYVIDGDKKKKVSELKARLKDADELLLATDEDREGEAIAWHLLEVLKPKVPVKRMVFHEITKDAINRALDNPRELDTDLVNAQETRRILDRLVGYEVSPLLWRKIRTGLSAGRVQSVATRMIVDRERDRMQFKSAEYWDLVAWLTPAAGGTEFSATLREVDGKRIATGKDFDEHGELKSAAQKSGVFALDGTAAQSLDDALSESATWSVDDIDSKPYRRRPPAPFTTSSLQQEASRKLRLNSRDTMRVAQSLYENGYITYMRTDSVNLSEQAISAARSLAVSRFGNDAVPDKPRVYETKTKGAQEAHEAIRPAGEKFQLPSSLEGKLDPREWKLYNLIFRRTLACQMNDATGTTVSVKIAAVPADGSVRAEFGASGTVIENPGFLSAYEEGRDEGDEPAATPGGGKTGEARLPRMQAADRLQLDHLDSGEDRQHFTTPPARYTDASLVKAMEEREIGRPSTYASTISTIVDRQYVYRRGQALVPSWLAFSVVKLLEENLPGLIDYDFTADMEADLDKIAAGKADRTQWLKNFWYGQGKGSDLQGLGLQRAVAELGDIDAAALNTVELGEGIALRVGRYGPYLQRGEERASVPDTVAPDELTLQVAKELLEKGAQGDRVLGVHPETGLEIVAKNGRFGPYVEELQPEPQAETDGETKPKKTAKKKTKNRTSSLLKTQSLDTLTLEDALQLLSLPRTVGQDSEGVDIVASNGRYGPYIKRGTDTRSLESEEQLFTLTTEQALALLAAPKTRGRAATSQTVMMEFGEDPETGQKVTLKNGRYGPYVTDGTTNATVPRGTDPATLTESAAFELLAIKRAKGPTKKRKAPARKTTAKKTAKKTTAKTAKK
(80) DNA topoisomerase 1 [Chlorobium limicola DSM 245]
1
MASKTEALSARNRTLIVVESPSKAKTINKYLGDRYTVFASVGHIKDLPKREIGLDFDHNYEPRYEVIAGKEKVVRQLKKLAGEADSVLIATDPDREGEAIAWHISNEIEAARKPVFRVLFNEITKNAILAAISEPRQIDYRLVRSQQTRQGLDKIVGYKISPFLWNVVLRGLSAGRVQSVALRLICEREEEINRFEIQEYWTVSADFATAKGEIFKAKLVKVDGGKPELSSQEQAEAAASLVRNRLYAVGDITAKAQQRKAPLPFTTSLLQQAASNQLGFGSQKTMRIAQQLYEGIDLGSEGATGLITYMRTDSTRIGSEAVAEAHKYIRAVFGSEYTGYGSSAKSPKNAQDAHEAIRPTSIERKPEAMKPYLSADQYRLYELIWKRFLAAMMAPAKIEQTKVDVEDHERRIVFRANGSRVLFPGFMRVYDDQQELEYEARTSTKEDVEKEQTVKLPDTLAARDSLNLDEIEQKQSFTRPPARYSEATLVKDLDNYGIGRPSTYASIFSTLQDRRYVVLQKKKIAPTDLGKDVSQILVANFPDIFNIRFTAFMEDELDKVAAGDDEYEKVLDSFYRPLETALSLRKNDPLIPQNMNAETCDKCGEGRMIIKWTASGKFLGCSRYPACKNIKPISSTKAKPKETGIKCPSCSDGQMLLRDGRLGPFLACSGYPKCNTLLNLSKQRHIEPLKTPPVQTDLPCPKCGAPLYLRSGKRGLWLGCSKFPKCRGRLAWNSLDPALQLHWEGVMAEHRKAHPDVVLTMTDGRPVPMTLPVDDIMARAEENGLIAPVTEENEGVTV
(1365) DNA topoisomerase 1 [Micrococcus luteus NCTC 2665]
8
MSTPPASVTASVPEGKKLVIVESPAKSKSIAKYLNAVGSGWVVDSSVGHIRDLPKPSDLPADMKKGPFGKFAVDTEHGFTPYYVVHPDKKKKVTELKRELKDAEALYLATDADREGEAIAWHLLDTLKPTVPVYRMTFGEITQEGVRRGLENIRELDTALVDAQETRRILDRLFGYELSPVLWRKVSRGLSAGRVQSVATRLVVERERERMAFVSAHYWGVEGTFTVAEGAQAADAVGSSFTARLSTVDGERVATGRDFDDAGRLKASAGKKVTHLDEAGARSLAEGLRGADFTVDSVEDKPYTRRPAAPFTTSTLQQEAARKLRMSSRVSMQVAQRLYENGYITYMRTDSVNLSQEAVQAARRQATELYGADAVPAQPRVYAKRNETAQEAHEAIRPAGDSFRTPAQVKAELRPDEFRLYELIWKRTVASQMADAKGYTATLRLSAAAQDGRLAQFSASGTVITFKGFLDAYEEGRDAEVDGENAEAKDRRLPQVAQGERLTGDPIEATGHETSPPARYTEASIVAELERREIGRPSTYAPTISTIMDRGYVSKRGTALVPSWTAFAVIGLLEDYFATYVDYDFTARMEDDLDRIAAGELGREAWLQTFYFGAPAAETEKGVEGLKHVVDNLGEIDARAVNSLPITEDITLRVGQYGPYLERSLPADAEAGATPPRANVPEDLAPDELTPAKAEELFATARPSERELGTDPETGRTVVAKDGRYGPYVTEVIPEMTEEELQAWLDAQPTEYYKNGKPKPKKKPAKEKPRTGSLFTSMSVDTVTLEQALQLMSLPRVVGADAEGEVITAQNGRFGPYLKKGSDSRSLESEDQIFSITQEQALEIYAQPKQRGRGAAKPPLAEFGEDPVSGKKVTVKEGRFGPYVTDGVTNITVPRDRQPEELTAEEAYQLLADKRAKGPATRGGAKKPAARKAPAKKTTARKKA
(563) DNA topoisomerase 1 [Arthrobacter arilaitensis Re117]
8
MPPKAKEKTGKKLVIVESPAKVKSIAKYLGEGFDVDASVGHIRDLPQPSELPTELKKTSVGKFAVDLDNDFEPYYMVYPDKKKRVSELKAKLKEADELYLATDADREGEAIAWHLLQVLKPKVPVRRLAFTEITKEGIARALENMRELDTDLVDAQETRRVLDRLYGYEISPVLWRKVARGLSAGRVQSVATRLVVERERERMAFIPAGYWDVKGNFATSEGEGFAAKLSAVDGARVASGRDFDDRGQLKTTRSKLAHLDQDSAQSLVANLSDTDFAVTSVEDKPYTRRPAAPFTTSTLQQEASRKLRWSSKITMQIAQRLYENGYITYMRTDSVFLSGEAVNAARKQATELYGADSVPAKPRVYKAKNDAAQEAHEAIRPAGDMFRRPKDVRSSLSKDEYALYELIWKRTVASQMADAKGFTATIKLQGTASDNRVAEFSASGTVITFRGFLSAYEEGKDEQALEAAAENAEARLPQLRVGQHLAGDELIALGHETTPPARYTEASIVAELEKREIGRPSTYAPTISTIMDRGYVTKRGGALVPSWIAFSVIRLLEEHFAKYVDYDFTARLEDDLDEIAKGQRARTDWLNLFYFGKGAEAQGEGLKHVVDNLGDIDARAINSIKITDDITLRVGKFGPYLERAIPEGAEEGTDPQRANVPEDLAPDELTAEKAEELFANSQVSEMDLGTDPETGRKIVAKDGRYGAYVTEIIPEPTAEELAAQPVEYYKNGKPKPPKKPTKVKPRTASLFKSMTVESVTLEEALKLMSLPRVLGADAEGEEITVQNGRFGPYLKKGSDSRSIESEEQIFTITLDEALAIYAQPKQRGRRAAVPPLAEFGVDPTSEKNIVVKDGRFGPYITDGITNITVPRTTSLEELTREQAIELLADKRARGPVKRTAKKAPAKKPAAKKAPAKKTTAKKTTAKKTD
(1559) DNA topoisomerase [Rubrobacter xylanophilus DSM 9941]
7
MRLIVAEKPSVGRDIAGALGRHRREGDALVGSGWVVTWALGHLAELAPPDAYGAEYKRWSLQNLPILPERFRVRVNPRTRERFEAVRRWMRDPSVTEVVNACDAGREGELIFAYLYQLSRCEKPVRRLWVSSLTPEAIREGFGSLRDGPSMKPLEDAARSRAEADWIVGMNATRAYSVRFSRPGDVLSVGRVQTPTLRLLVEREREIEDFRPERFFTVHARFARDGKTYDGLWFREKESRLKEREAAEQIAEKVRGGTGVVKKAERRRTSERPPLLYDLTELQRNANARYGFTAERTLRAAQALYEERKLITYPRTSSRYLSGDMVGTLKRRVEAAGGLPELAPFAGRLLAAGSLPVGRRVVDDSKVTDHHAIVPTDRKPSGGLPPDEAKVYDLVARRFLAVFFPAARFENTTVVTEARGETFLSKGRVVLEAGWRELYPDGVGGRKEKEPPALPPVEAGQEWRVAKVGVKEGETKPPPRYSESALLGAMETAGKLVEDEELRQQMKDSGLGTPATRAAIIERLIKVGYVEREKKALVPTAKGRALISLLADSPLSSPEMTARWERRLARIERGEERRPDFMSDISGFAASVVEGVRRMEGEKIAAPGGGGEALGACPKCGSPVVETKKAYGCSAWRKTGCDFAIWKRVAGKRVSESQARQLLAKGRTARLKGFKSRAGKPFSAALVLDGEHRVRLEPFRG
(374) DNA topoisomerase 1 [Rubrobacter xylanophilus DSM 9941]
3
MRLIISEKANAARKIAQFLAEGPVKEGKHRSVPYHTFTWRGEECVSVGLKGHVLNPEYPEEYSNWQKVDPRELIDARILKSVSEKGVAAAVRSLAKKADRVIIATDFDREGELIGVEALSLAFEANPALMDHVERARFSALTKGEVTRAFENLVEVSRELADAGEARQDIDLIWGATLTRWVSRAVKRYGSAFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQNGGGPFVARHARGRFKEEAEARRALENLSETAVVTEVRQREATRPAPAPFNTTAFLTAAANIGVSPSRAARIAEDLYTEGYISYPRTDNTVYPESLDLREVLGFLAEVEGVGDYAGRLLGAGRLTPTRGRRQTTDHPPIYPTGRASRAELREDQWKIYQLVVRRFLATLSGPAKTLRTTLRFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEELPRLSEGDEVRVAEAELLAKETQPPGRYGQGRLIRLMEDLGLGTKATRPGIIQNLYDRGYIHGDPIVPTETGMAVAKALKDFASEIASHEMTARLEKSMDAISEGRVSKDSVVEESRELLRRVYDHLESSEEKFADIVWNGIRGDETLGPCPNCGRNLVVRRNRRNRKRFAGCEGYPECRTTFPLPQKGDIIPLGTACEACGLPEIKVLGGRRPWVTCINMDCPKKQEQRRSREETQAGGEEPSEGQRDRKRLEKSTT
(674) DNA topoisomerase 1 [Chloroflexus aurantiacus J-10-fl]
1
MGEKVVIVESPAKARTIQKYLGKGYKVASSMGHVRDLPKSGLAIDIEHDFAPSYEIVKPKVVSELSQALRNAEAVYLATDPDREGEAIAWHITQAVKLPKKTPVYRVVFQEITRNAVQQALQQPRQINQNLVEAQQARRVLDRLVGYQLSPLLWDKVKRGLSAGRVQSVAVRLIVEREREIEQFQPQEYWTIEADLLKDAGVAPRDLFRAVLIERDGKKLEKFSIENREQAEAIVADLQGAAYTVVRVTRRDKRRSPAPPFTTSTLQQEAARKLGFSAKKTMTLAQRLYEGVDIGGEDGMVGLITYMRTDSVQVAAEAQTEARDVIGKRFGKEYLPDQPPVYKTKAKGAQEAHEAIRPTSSARLPEQLSGKLENDLWRLYDLIWKRFIASQMAPAVFDSTTVDIAATPVVAGAPAYLFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPPLAEGEALQLVELLPIQHFTEPPPRYTEASLVKELERLGIGRPSTYASILSTIQEREYVEMVDKKLIPTTLGRVVTDLLVEHFGNIVDYDFTSALEQQLDDIAEGSKKWVPVLREFYGPFRSTLEQAQRQMRNVKREEIVTDLDCPKCGQGKLVIRFGRNGEFLACSRYNREGDGESCDFTSDFHRDEQGQIVIDKASAPETSDVLCNVCGRPMVIKKSRFGPFLGCSGYPECNNTRRIGRDGKPVPLPEPTGVQCPKCGEGELLRRRGKFGRPFYGCSRYPKCDYITNTLDEAQAGEAPAEPAKNEPALPSPSRSSKRTRKSA
(177) DNA topoisomerase 1 [Arthrobacter chlorophenolicus A6]
8
MPSKAKTGKKLVIVESPAKSKTIAKYLGEGFIVEASIGHIRDLPQPSELPAELKKTSVGKFAVDIDHDFKPYYVVSPDKKKKVTELKAALKDADELYLATDGDREGEAIAWHLLEVLKPKVPVYRMTFGEITKEAIQRAMGNLRDVDQDLVDAQETRRILDRLYGYEISPVLWRKVARGLSAGRVQSVVTRMVVDRERERMAFKAASYWDLTGQFGADSGSFKAKLASVDGAKVATGRDFNDDGVLTSKNVAHLNEELAGSLAAGLQDAPFTVRSVETKPYTRRPAAPFTTSTLQQEAGRKLRFSSKSTMQIAQRLYENGYITYMRTDSSALSDEAVTAARRQASELYGPEYIPGSPRVYSNKAANAQEAHEAVRPAGDSFRTPAQVASQLRGDEFRLYELIWKRTVASQMADAKGSTATIRLGAVAVSGDAAGRDAEFSASGTVITFPGFLAAYEEGKDESRGDDDSDEARRLPNVAKGDSLKASDIVAVGHETSPPPRYTEASLTAELEKKGIGRPSTYASTISTIQDRGYVRKQGSALVPSWIAFSVIRLLEQHFSDYVDYEFTADMEGDLDKIANGQAAGTSWLRHFYFGEDSDPGLLSIVNNLGEIDAREINSIPITDQITLRVGKFGPYLESSAATVDPKTGEIVESPRANVPEDLAPDELTAAKAVELMETAAPEERVLGADPHTGHTVVAKNGRYGAYVTEVIPEMTEEQIAAQPVEYYKNGKPKPPKKPVKAKPRTGSLFKSMTVESVTLDEALQLMSLPRALGEDSEGNLITVQNGRFGPYLKKGTDSRSIGTEEEIFTITLEQALEIYSQPKQRGARAAVPPLAEFGPDPVSEKNIVVKEGRFGPYITDGITNITVPRATSLEELTREQAVELLAEKRAKGPVKRTATRKAPAKKKATAKK
(1843) DNA topoisomerase 1 [Kocuria rhizophila DC2201]
8
MASKATKNEGTGKSLLIVESPSKVKTIAGYLGDAYEVESSMGHIRDLPQPSELPTDMKKGPYGKFAVDVEHEFDPYYVVNPDKKKKVTELKRKLKDADALYLATDGDREGEAIAWHLLQVLKPKVPVYRLTFPEITKEAIERGFGQLRDIDQDLVDAQETRRILDRLYGYEISPVLWRKVAAGLSAGRVQSVATRLVVQRERERIAFVPADYWDLTGQFSRPEGQDAGRAFSARLSSVNGRRVATGKDFDDRGQLKSPSSGNAPVTLDEAVATALAAGLQDAPFSVRSLETKPYTRRPAAPFTTSTLQQEAARKLRFTSRTTMRVAQRLYENGYITYMRTDSVALSDQAVNAARAQAKELYGPEFVPSSKRVYASKSKNAQEAHEAVRPAGDTFRTPSQVRSQLSVDEYKLYELIWKRTVASQMQDAKGDTATVRLGATATSAAGEHAGADAEFSASGTVITFRGFLAAYEEGRDVNPDLTADSGKKGAKDEDKRLPVMAEGDALDASEVTADGHTTTPPARYTEASLVKTLDELGIGRPSTYAATISTIMDRGYVQVRGSALIPSWLAFSVVRLLEDHFSDYVDYDFTAELEDDLDRIARGEAERVKWLSGFYFGENPSEPGLKPIVDDLGEIDARAVNSIPITDEITLRVGKYGPYLEAGGTVDPETGEITDPVRANVPLDLAPDELTPEKAQELMEIGKADGRELGVNPANGRTIVAKDGRYGPYVTEIVPEPTQEELDAIPTEYYKNGNPKPKKIEKPKPNTASLFSSMNLQDITLDDALKLLSLPRELGQDTDGETITVQNGRYGPYLKKGSDSRSISSEDQIFTITLEEAKTIYAQPKQRGRQAARPPLADLGADPLTEKRMVIKEGRFGAYITDGETNVTVPRAEAVEQITAARASQLLAEKRAKGPAPAKSPARGKARTASKSSTSKASASKGTSSKAKAGTTTAKRASATKAKSTTGAARTTRKAPAKKSS
(1227) DNA topoisomerase 1 [Rothia dentocariosa ATCC 17931]
8
MRRAVPTKAKNGKALLIVESPSKVKTISGYLGNEFLVDSSMGHIRDLPQPSELPENLKKGPVGKFAVNIDDDFDPYYVVNPDKKKKVAELKRKLKDVDALYLATDGDREGEAIAWHLKEVLKPKVPVYRMTFPEITREAIERAFGELRDIDLHLVDAQETRRILDRIYGYEISPVLWRKVGRGLSAGRVQSVATRLVVERERERMAFVAANYWDLTGHFITTSNEGFDAKLVAVDGTRVATGKDFADDGTLTSTKVTHLSEADARTLAEALTAAPFAVRSVETKPYKRRPAAPFTTSTLQQEAARKLRFSSRVTMQVAQRLYESGYITYMRTDSVALSDQAVKAARRQASELYGTEYVPSAPRTYASKSKNAQEAHEAIRPAGDKFRTPDAVRGTLSNDEYRLYELIWKRTIASQMADATGSTASVRLGATASNGRDAEFAASGTVITFRGFLAAYEEGVDATRLAERDAKNAEKRLPALAQGDSLTAEKLEATGHETLPPPRYTEASLVKTLDELGIGRPSTYAAVISTIMDRGYVQVRSGSLVPSWTAFSVVRLLETSFGPYVNYEFTAQMEEDLDRIARGEESRVEWLGDFYFGGGVQKKRGLKPIVDNLGDIDARDINSIRIADGIVLRVGKFGPYLEAEGTVNTETGEVSDPVRANVPTDLAPDELTAEKAKELLEQGKSDGRVLGTDPASGNQIIARDGRYGPYVTEVIEEMTEEQIQAYLDAQPTEYYKNGKPKPKKKPKPAKPRTASLFKSMDLATLTLEDALKLLSLPRVLGTDAEGNEITVQNGRFGPYLKKGTDSRSIGSEEEIFTITLEQALDIYAQPKQRGRAAAKPPLAELGVDPNSEKNIVVKDGRFGPYITDGVTNITVPRSETIESLTHERAVELLAEKRAKGPAKRKTAAKKTTAKKSTAKKTTAKKSTTAKKTAAKKE
(1408) DNA topoisomerase 1 [Rothia mucilaginosa DY-18]
8
MPAQAKTGKALLIVESPSKVKTISSYLGEDYLVDSSMGHIRDLPQPSELPENLKKSPVGKFAVNVEENFEPYYVVNPDKKKKVAELKRKLKEVDALYLATDGDREGEAIAWHLKEVLKPKVPVYRMTFPEITREAIQRAFGELRDIDLHLVDAQETRRILDRIYGYEISPVLWRKVGRGLSAGRVQSVATRLVVERERERMAFVAANYWDLSGRFLTAASEGFDAKLVAVDGNRIATGKDFADNGTLNTSKVTHLNEEAARALAAALQSAAFSVRSVETKPYKRRPAAPFTTSTLQQEAARKLRFSSRVTMQVAQRLYENGYITYMRTDSVALSEQAISAARRQASELYGAEFVPSAPRVYTSKSKNAQEAHEAIRPAGDTFRTPDAVRGSLSNDEFRLYELIWKRTVASQMADATGSTASVRLGAVASNGQDAEFAASGTVITFRGFLAAYEEGVDASRVAEREAKDAEKRLPNLTTGEALTAEAIEPAGHETLPPPRYTEASLVKTLDELGIGRPSTYAAVISTIMDRGYVNVRSGSLIPSWIAFSVVRLLESSFGPYVNYEFTAQMEEDLDRIARGEESRVEWLGEFYFGGGSKRGLKPIVDNLGEIDARSINSIPIADGIVLRVGKFGPYLEAEGTLDTETGELTEPIRANVPADLAPDELTEEKARELLEQGKSDGRVLGVDPVSGNQIVARDGRYGPYVTEVIEEMTEEQIQAYLDAQPTEYYKNGKPKPKKKPKPAKPRTASLFKSMDLATVTLEQALQLMSLPRVLGTDAEGVEITVQNGRFGPYLKKGTDSRSIGSEDEIFTITLEQALEIYSQPKQRGRAAAKPPLAELGVDPVSEKKIVVKDGRFGPYITDGITNITVPRAESVESLTHERAVQLLADKRAKGPVKRKTAAKKTTTAKKTTAKKTTTRKTAAKKTAE
(1162) DNA topoisomerase 1 [Isoptericola variabilis 225]
8
MPHPRKLVIVESPTKARKIQGYLGDDFEVEASVGHIRDLPQPSELPAEMKKGPYGKFAVDVENGFEPYYEVYADKKQKVRELKRALKEADELYLATDEDREGEAIAWHLIQELKPKVPVKRMVFHEITREAIQRALENTRDLDEHLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVAADYWDVSGSFAPESGEDAGQAFRARLTGLGADRVAAGRDFDDKGRLKVRTGVVHLDEAAANAVVAGLADASFTVRSLETKPYSRKPAAPFTTSTLQQEAGRKLRMSSRQTMRTAQALYENGYITYMRTDSPALSAEATEAARRQAAELYGPEYVPGAPRLYASKNKGAQEAHEAIRPAGDAFRTPAQVARELSGDQFRLYELIWKRTVASQMADAKGSTASVRLGATLGAGAGDLAGTDAVFSASGTVITFRGFLAAYEEGRDVEAPDDAAASGRETRLPRMAEGDALAGTDLAAEGHSTAPPARYTEASLVKALEELGIGRPSTYAATISTIQDRGYVRTRGQALVPTWLAFAVVKLLEEHFDWLVDYDFTAEMEADLDQIAAGDRERVAWLSRFYFGDGSGQTEGWGLRDLVENLGEIDPVSVNSIEIGEGIRVRVGRYGPYVEDLGAEVGEGQNPPRASIPDDIAPDELTVAVARELLAAGADDGRVLGTDPETGHQIVAKAGRYGPYVTEVLPEPELDPNLSATARKKALAALPKPRTASLFKSMTLESVTLDDALRLLSLPRVVGTDPESGEEITAQNGRYGPYLKKGTDSRTLASEEQLFTVTLDEALKIYAEPKRGRGARAATPPLRELGDDPTTGKPIVIKEGRFGAYVTDGETNRTLPRDVTPDSITPERAIELLAEKRAQGPAKKRRTTTTTRKKATTTKKS
(435) DNA topoisomerase 1 [Microbacterium testaceum StLB037]
8
MANGKKLVIVESPTKMKSIQGYLGDDYEVLSSVGHIRDLASKKEIPADKKAAYGKYSIDVENDFDPYYVVNDRKTKTVAELKRALKTADEVLLATDGDREGEAIAWHLLEVLKPKVPVRRMIFHEITKDAIREAAEHTRDLDVSLVDAQETRRVLDRLYGWDVSPVLWRKVGSGREGTALSAGRVQSAATRMVVERERERMAFVSASYWDVEALASQAGSSFTTRLNRLDGAPIARGGDYDDNGQLKKAVVVLDEAQARALADAVTAAGRATVAKVEAKPGTRSPRAPFTTSTMQQEAGRKLSMSAKHAMGVAQRLYEKGFITYMRTDSVALSAQAISAARAQAVSLYGDKAVPANPRVYKSKSKNAQEAHEAIRPSGETFRTPASVASSLDRDEQKLYDLIWKRTVASQMADAKYETTTVTLTVQAGEKVAEFTASGTVYTFKGFLEAYEEGADEKRNGRDADEDQSLPAVTVGDELTVSDVEPKGHSTSPKPRYTEASLVKALEEKGIGRPSTFASIIGVILDRGYVTKRGQALVPSWLAFSVVRLLEEHFADLVDYDFTAALEDDLDAIARGEQRRTEWLKEFYFGSDKQIGLRHIVDNLGEIDARELNSTRITDTATLRFGKYGPYLEVTEPGADPEAKPRIVNIPEDLAPDELTPEKAQELIDAPVAGDRVLGENPENGKLIVVKDGRFGPYVQELEPEEPEEVDAATGEVIEQPKKKTTKKEAAPKPRTASLFRSMSVDTIDLDTALQLLSLPRVVGVDPESGAEITAQNGRFGPYLKKGTDSRSLDDEKQIFDITLEEALAKYAEPKYGARRASSALKEFDADPVSGKPIKLKDGRFGPYVTDGETNATVPRGEDAMAITFERAVELIADKRAKGPAPKKTAARKTTTTRKAPAKKS
(1836) DNA topoisomerase 1 [Leifsonia xyli subsp. xyli str. CTCB07]
8
MWAALAAIEAALGGGATARSSNRSCVQILARSKVPATKKLVIVESPNKMKSIAQYLGDGYEVMASVGHIRDLIEPKNLPPELKKGSLGKFSVDVENEFEPYYVVSDQKKKTVADLKRALKDADELLLATDEDREGEAIAWHLVEVLKPKVPVKRMVFHEITREAIEKARDNTRQIDTALVDAQETRRILDRLYGYEVSPVLWRKVGPGLSAGRVQSAATRLVVDRERERLAFVAASYWGLTAELAPEEAPSFGARLARVDGDRIATGRDFDDHGRLTSGARTLDEVAAQELTEAVRKPSTVVSVAKVDSKPYSRRPAAPFTTSTMQQEAARKLRFSARQTMSVAQSLYENGYITYMRTDSASLSQQATNAARAQAAKLYGPETVPEKPRVYTSKSKNAQEAHEAIRPSGETFRTPAELEKSLRGPELRLYDLIWKRTVASQMADAKGQTASVTVEAAIAEGQLEGTVAEFTESGTVITFRGFLGAYEEGRDEERNASDTGESKLPPLTAGQTLSVQEVAADGHETTPPPRYTEASLVKSLEELGIGRPSTFASIISTIIDRGYVTQRGQALVPSWVAFSVVRLLEDYFGDLVQYDFTAEMEDDLDRIAGGVAARVDWLNSFYFGSDKHMGLRRVIDNLGEIDARSINSIAIEDGVTLRIGKYGPYLELTEPAATEGTSPRRVTIPPELAPDELTPAKARELIEAPVQTDRVLGTNPANGKLVLAKDGRFGPYVTEADPEEPEADQRTGEVIEARKPAKKAAAPKQRTASLFKSMDLASVDLDTALRLLDLPRVVGVDPESGDEIQAQNGRYGPYLKKGTDTRSLPGEDDIFAVDLVGALDLFAQPKYGNRRVSSALKEFDPDPVSGKPIKVKDGRFGPYVTDGETNATIPRGETVDEVDFERAVQLLADKRVKGPAKKTASRASAAKKTTAKPAAAKKTAAATSAAATSTAEKTTAAKKAAAAAKTTASTAAEPTAADAE
(1367) DNA topoisomerase 1 [Kytococcus sedentarius DSM 20547]
8
MAAKGSKLVIVESPTKVKSIGQYLGDEYRVEASVGHIRDLPTPSEMPADMKTGPYGKFAVDVDNGFDPYYVIDADKKKKVTELRKALKEADELYLATDEDREGEAIAWHLLQALKPKVPVKRMVFHEITKDAIQHAVNTTRDLDDRMVDAQESRRILDRLYGYEVSPVLWRKVKQGLSAGRVQSVATRLVVERERARMAFRIASYWDVEADLAPADDQQFTARLTSLDGVRVATGRDFTDAGELKSSAQVTHLAEADARAVASGIEAAQVTVTDVSEKPYTRKPAAPFITSTLQQEASRKLRLGSKDAMRVAQRLYENGYITYMRTDSTTLSQSAMTAARQQARDLYGADYVPDSPRFYGKKAKGAQEAHEAIRPAGDTFRTPAQVAGELRGSEYAMYELIWKRTVASQMADAKGSTATVRIGAPLQGVQVGGKPARQAELTASGTVITFRGFLAAYEEGRDADRYGGGEQGGSGDAGAKSGKGAKEVRLPKMAAGQELATSRVEALGHETSPPPRYTEATLVKALEEKGIGRPSTYAATVGTIQDRGYVRTKGNALVPTWLAFAVTTLLEKHFPTLVDYDFTASMEEGLDAIAAGEEDRVAWLQRFYFGDEASSATGLRELVEDLGEIDAKGVSTIDIGDGIVVRVGRYGPYVEEIAPAGTDLTTGEVPDDAGSAARAADGTAASGEEEAKPLRASIPEDIAPDELTPAMAREYLAEAASDGRVLGQDPETGRDIVAKTGRYGPYVSEVFTDEDVARFEAEGKKTTGRGKDLVKPRTGSLLASMDVRTVTLEDALKILSLPRVVGADPESGAEITAQNGRYGPYLKKGTDSRSLASEEQIFEITLEEALKIYAEPKRRGRSAANPPLAEFAEDPVSGKKVVIKDGRFGPYITDGETNVTVPRAMRPEDVSELQAFELLAQKRAEGPKKKPVRKSSGTTRKAPAKKPAAGTARTVKAGSRKKS
(1527) DNA topoisomerase 1 [Intrasporangium calvum DSM 43043]
8
MAAGKGRKLVIVESPGKVKSIASYLGGDYEVEASIGHIRDLPNPSELPAEMKKGPFGKFAVDVDHGFEPYYVVDADKRKKVAELKRKLKDASELYLATDEDREGEAIAWHLLEALKPRVPVKRMVFHEITREAIQRAVNDTREIDQDLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRMVVERERERMAFVRASYWDVEGDFTPDGATQQFTARLSGVDGARVATGRDFADDGRLTGRNVVHVDEALARRIAEACLSVGQGATRVTDVQEKPYTRRPSAPFTTSTLQQEASRKLRMSSKNSMRVAQRLYEGGFITYMRTDSTTLSDAALTAARSQARDLYGAEYVPDAPRRYEKKVKNAQEAHEAIRPAGDRFRTPAMVAGQLRGEDYALYELIWKRTVASQMADARGSTATVKLSVDTAVESARQVEFSASGTVITFKGFLAAYEEGRDDEALARADAAAEERRLPRLSSGVALQVVRAEADGHETAPPARYTEATLVKAMEEKGIGRPSTYASTIGTIQDRGYVYSKGQALVPTWLAFAVTRLLEEHFSELVDYEFTASMEEDLDRIAGGELARVDWLKRFYFGDEASTAEGLKELVDDLGEIDAREISTIPLGDGMVVRVGRYGPYVEETAPHGVDLETGELAAGTDAAEVPTTPRRATINDDIPPDEMTPARARELLEAAADDGKVLGRDPETGREIIARAGRYGPYVTEVLPEPEPELTASGKPKKVAKAKPRTASLFKDMDLGTIDLETALQLLSLPRVVGTDADGVEITAQNGRYGPYLKKGTDSRSLQSEQQLFDITLDQALAIYAQPKQRGRGAATAPLKELGEDPVSGKPVVVKDGRFGAYVTDGETNATLRKDDDPATITPERGFELLAEKRAKGPTTRKRATKKTAKRATKKAPAKRATKKATTKKA
(1380) DNA topoisomerase 1 [Corynebacterium ulcerans 809]
8
MAEKSGPKRLVIVESATKAKKIAPYLGDDYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNTENGFAPLYVVSADKKKKVADLKQKLKLVDELLLATDPDREGEAIAWHLLEVLKPKVPVKRMVFNEITKPAILAAAENTRELDANLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFVSAEYWDIEAEFDTGKPDTDGNPHQFTGRLTSVDGKRVATGRDFNDRGELKGDVVVVDKQRAEALAAELTGAPMSVAKVEEKPYTRRPYAPFMTSTLQQEAGRKLHFTSERTMRIAQRLYENGHITYMRTDSTTLSEQGLKAAREQAISLYGNDYVADGPRRYDRKVKNSQEAHEAIRPAGERFATPGELHSQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTIAGKNAEFSATGRTITFPGFLRAYVEITKLSDGRDLADNAEHHLPRLAEGDALDVNKLEVDEHSTNPPARYTEASLVKKMEELGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEKSFSALVDYDFTSSMEDELDDIAAGREDGTAWLTGFYFGDAEASDATAESIARHGGLKALVGDNLEHIDARLVNSLELFQDSEGRAVNVRVGRYGPYIERQIGVTADGEAEYQRANLSDTTTPDELTLEVAEKLFATPQSGRELGRNPKNDRMIVAKEGRFGPYVTELVNEDERIQVETKAEEIVAAERKAEDEQRAAEGKRAKNWETKTAVKQKEKRIAEIVDETLKPGTASLFKAMEPATVTLEEALQLLSLPREVGVDPSDNEPITAQNGRYGPYLKKGNDSRSLAKEEQIFTITLDEARRIYAEPKRRGRGATSQSVIKELGDNDVSGKPMSVRDGRFGPYVTDGTTNASLRRGDDPTALTDARANELLSERRAKEAADGGTAKATKKTTKKTTAKKAVKKPAKTTKRVVKAGRKK
(1548) DNA topoisomerase 1 [Cellulomonas flavigena DSM 20109]
8
MSAGRKLVIVESPAKARTIAGYLGDGFDVEASVGHIRDLPQPSELPADMKKGPYGKFAVDVENGFTPYYVVDADKKKKVAELKKLLKESDELYLATDEDREGEAIAWHLLAELKPKIPVKRMVFHEITREAITRALENTRELDERLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVAADYWDVTGTFAVADDSEPTFSARLTGVGGARVASGRDFDDRGALKTRDTVVLDETRAHALVAGLDGAAFTVQSLETKPYTRRPAAPFTTSTLQQEASRKLRMSSRQAMRTAQTLYENGYITYMRTDSPALSTQAVDAARRQVAELYGADHVPDKPRVYTSKAKGAQEAHEAIRPAGDHFRTPAQVARELSGDQFKLYELIWKRTVASQMADARGQTASVRLAATARTADGPVETVFSASGTVITFRGFLAAYEEGRDRGRYDEAEGGASGSDDARLPQMAQGDPVTGSDLTADGHRTSPPPRYTEASLVKALEERGIGRPSTYAATIGVIQDRGYVTNRGQALVPTWLAFAVTRLLEENFDRLVDYNFTAGMEESLDAIAAGQKGRVDWLTEFYFGDRSDSVASGGLRGLVDNLGEIDAREVNSIEIGDGITLRVGRYGPYLEAPGEGPDDEPRRSSVPDDLAPDELTVAKARELLETMPDGDKVLGTDPGSGHQIVARNGRYGPYVTEVLPEPELDPGLSAAARKKALAAAPKPRTGSLFKSMSLATVTLDDALRLLSLPRVVGADPETGAEITAQNGRYGPYLKKGTDSRTLASEEQLLTITLEEALAIYAQPKRGRGQTAAAPLRELGTDPTSGRPIVVKDGRFGAYVTDGETNRTLPRDVTPESITPEQAVELLAEKRAAGPAKKKTTTRKTTTRQKSAAKS
(425) DNA topoisomerase 1 [Corynebacterium pseudotuberculosis 3/99-5]
8
MPFPALLVFLDACVGQRCVVDPYYKVPTHFYRAFCELRFSPFMAEKSGPKRLVIVESATKAKKIAPYLGDDYIVEASVGHIRDLPRGAADVPTKYKKEPWARLGVNTENGFAPLYVVSPDKKKKVADLKQKLKLVDELLLATDPDREGEAIAWHLLEVLKPKVPVKRMVFNEITKPAILAAAENTRELDANLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFVSAEYWDIEAEFDTGKPDTDGNPHQFTGRLTSVDGKRVATGRDFNDRGELKGDAVVVNKQRAEALVAELTGAPMNVAKVEEKPYTRRPYAPFMTSTLQQEAGRKLHFTSERTMRIAQRLYENGHITYMRTDSTTLSEQGLKAAREQAISLYGNDYVAEGPRRYDRKVKNSQEAHEAIRPAGEHFATPGELHAQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTIAGKNAEFSATGRTITFPGFLRAYVEITKLSDGRDLADNAERHLPRLAEGDALDVNKLEVDEHSTNPPARYTEASLVKKMEELGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEKSFSALVDYDFTSSMEDELDDIAAGREDGTEWLTGFYFGDAAASDATAESIARHGGLKALVGDNLEHIDARLVNSLELFQDSEGRAVNVRVGRYGPYIERQIGVSADGEAEYQRANLSDTTTPDELTLDVAEKLFATPQSGRELGRNPKNDRMIVAKEGRFGPYVTELVNDDERAQVEAKAEEIVASERKAEDEQRAAEGKRAKNWETKTAVKQKEKRIAEIVDETLKPGTASLFKDMEPATVTLEQALQLLSLPREVGVDPSDNAPITAQNGRYGPYLKKGNDSRSLASEEQIFTITLDEARRIYAEPKRRGRGATSQSVIKELGDNDVSGKPMSVRDGRFGPYVTDGTTNASLRRGDDPTELTDARANELLSERRAKEAADGGAEKKATKKAAKKSTKKTTAKKAVKKPAKTTKRVVKAGRKK
(1825) DNA topoisomerase 1 [Corynebacterium variabile DSM 44702]
8
MGAQGSVSGGKKFVIVESATKAKKIQKFLGDGFIVEASVGHIRDLPRGAADVPPKYKKEQWARLGVNVDDDFQPLYIVSPDKKKKVADLKAKLKQADELLLATDPDREGEAIAWHLLEVLKPKVPVRRMVFHEITPEAIREAAENTRELDFDLVDAQETRRVLDRLYGYEISPVLWKKVMPRLSAGRVQSVATRVIVRRERERMAFVRAGYWDLTATLDTGDRGQDATTNPRKFDANLVAVDGARVAQGRDFNDDGKLKTGKAQANVTVLDKARAEALSSALTGTTMAVTNVEEKPYTRRPYAPFMTSTLQQEAGRKLHFTSERTMRIAQRLYENGHITYMRTDSTTLSASGISAARQQAKELYGPSFVADAPRQYTRKVKNSQEAHEAIRPAGETFNTPGALASQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTVSGEATSGEAVDFQATGRTITFPGFLKAYVETTRTADGRDVADNAEKALPVLTVGDALDAAEIAAKGHETQPPARYTEASLVKTMEELGIGRPSTYASIINTIKDRGYVVSRGSALVPSWTAFAVVGLLENNFGSLVDYEFTSSMEDELDEIARGEENRSHWLKGFYFGDPEASDATAESVARLGGLKHLVNDNLEQIDARKVNSLHLFDDANGVPVVVRVGRYGAYLERIIPAEPGATTESGEPAEPTVQRANLPEALLPDELTLEVAEKLFATPQGGRELGVNPANGRVIVAREGRYGPYVTEKVKDDEEARVTAEAEKVIDAERDAEDAARAEEGKKPLSRETKTAENKKAKRIKEILEETLKPKTASLLKTMDPATVTLEDALKVMSLPREVGVDPSDGEMITAQNGRFGPYLKKGNDSRSLASEEQIFTVTVDEARRIYAEPKRRARAAAKPPLKQLGDNDVSGKPMTVKEGRFGPYVTDGETNASLRRGDTPETMTDARGNELLSERRAKEAADGGASKKSAKSARKTTKKATAKKTTAKKTTAKKTTAKKTTKKAAAKKS
(520) DNA topoisomerase 1 [Corynebacterium kroppenstedtii DSM 44385]
8
MKRLVIVESATKARKIQPYLGSDYIVEASVGHIRDLPRGAADVPAKYKKKPWARLGVDVENDFAPLYVVNQDKKKKVADLKAKLKQVDELYLATDPDREGEAIAWHLLQVLKPKVPVRRMVFHEITKPAILEAAKHTRELDQNLVNAQETRRVLDRLYGYEISPVLWKKVMPRLSAGRVQSVATRVIVERERDRIAFTSADYWDLTGTFALRSGADASTPGSSTAGADTASGEPRSFPARLAEIDGQRVAQGRDFNDDGQLKSKAVALDEKAAKDLADQLSGAAMSVRSVEEKPYTRRPYPPFMTSTLQQEAGRKLHYTSERTMRIAQRLYENGHITYMRTDSTTLSESGINAARAQARELYGAKYVASAPRQYSRKVKNSQEAHEAIRPAGESFATPGQLGGQLDAEEFKLYELIWQRTVASQMADAKGTSMKVFVAGESTDGRDCVFTATGRTITFPGFLKAYVEVSRTADGRNVADDAEKRLPVLTEGQGLTATDIEADGHSTTPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEQNFGSLIDYDFTSSMEDVLDSIANGSEDRSHWLEGFYYGDDGASSAKAETIARLGGLKHLVGGNLETIDARAVNSLHMFDDEDGNPIVVRVGRYGPYLERTPAGSDEPQRANLPDTVTPDELDLALAEKLLATPPTGRELGENPANGRMVVAKEGRYGPYVTELVRDDEREKAEAKALETVDAEWDADDEARKAEGKKPLNRETKTAAKKREKRVNELVTEMLKPKTASLFSGMEPSTVTLDEALKLMSLPREVGVDPSDGEVITAQNGRYGPYLKKGTDSRSLANEEQIFTITLDEARRIYAEPKRRGRAAAKPPLKQLGDNDVSGKPMTVKEGRFGPYVTDGETNASLRRGDTPEAMTDARACELLSERRAKEAANGGAKKKSSKKGTRKSTKKSGRKSTSKASKKTSKKSPAKKTVKS
(1086) DNA topoisomerase 1 [Mycobacterium gilvum PYR-GCK]
8
MADGDRGSGKNGSVRRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPDKKATVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQATPPTFVAKLNTVDGRRVAAGRDFDSLGAVKKPGEVLVLDEAAANALAGGLRGAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRMSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSQLDTDEFRLYELIWQRTVASQMADARGTTLSLRIAGAATSGEQVVFNASGRTITFAGFLKAYVESLDEQAGGEADDAESRLPNLTQGQRVDAKDLTADGHTTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFSRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGEHGVEGSIAREGGLKKLVGGNLEEIDAREVNSIKLFDDSEGRAVNVRVGRNGAYLERMVADPDNPGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGIDPATGHEIVAKDGRYGPYVTEVLPEPPDDGEAGATAKKGKKPTGPKPRTGSLLRSMDLETVTLDDALRLLSLPRVVGVDPANGEEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPVKKKAAKKAAVKKTAAKKAAKKAPAKKAAKKA
(781) DNA topoisomerase 1 [Corynebacterium resistens DSM 45100]
8
MAKDDLKRLVIVESATKARKIAPYLGPNYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNVDKEFEPLYVVSADKKKKVSDLKAKLKQVDELYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFHEITKPAILAAAEDTRELDQDLVDAQEARRVLDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFVSAEYWDLTAKLNLQTAGLDGEPNSFEARLATVGGKRVAQGRDFNDDGQLKSEAVVLDGGSANALATDLTGSDMQVTGVEEKPYTRRPYPPFMTSTLQQEAARKLRFTSERTMRIAQRLYENGHITYMRTDSTTLSQSGMQAARAQAKELYGAKFVANAPRQYNRKVKNSQEAHEAIRPAGETFDTPGQLAGKLDAEEYKLYELIWQRTVASQMADAKGMSMKVTVAGSSSQAAEVPGITSTEVEFTATGRTLTFPGFLKAYVEVSSTGDGKDMADNAEKRLPVMSQGDALKASEVTAEGHTTNPPARYNEASLVKRMEELGIGRPSTYASIIRTIQDRGYVLPRGNALVPSWVAFAVVGLLEQNFGSLVDYDFTSAMEDELDAIAEGRTDRANWLRGFYFGDDSRDKDSPSSAIPRQGGLQHIVGDNLEQIDARRVNSLHLFDDAEGNPIVVRVGRYGPYLERVKPVPAGAPEGTEPEVQRANLPESMTPDGLTLDVAEKLFATPQGGRELGVNPESGRTIVAREGRYGPYVTELLGEDEEAQAAAKAEAQWEAERDEQDREREAEGKKPLSRETKTAQNQKAKRVKELVEASLKPKTASLFSDMEPASVTLEEALKLMSLPREVGVDPSDGEMITAQNGRFGPYLKKGSDSRSLANEEQIFTVTLDEARRIYAEPKRRGRAAAKPPLKQLGDNDVSGKPMSVKEGRFGAYVTDGTTNASLRKGDTPETITDARANELLSERRAKMAAEGTAPAKSARKAAKKSTRKTSAKKTTKKAGAKKTGTKKSTKKAPPTLTKRTVKRSH
(1056) DNA topoisomerase 1 [Nocardia cyriacigeorgica GUH-2]
8
MIVESPTKARKIAPYLGRNYTVEASVGHIRDLPRGAADVPAKYKGQPWARLGVDVDHDFEPIYVVSPDKKGKVTELKSLLKDADELYLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIQAAAADTRDLDSDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVRRERERMAFRSAEYWDIAAKLDAGETGEVGNPRTFGARLVNVDGARVASGRDFGSDGQLKADSGVVVLDEAYARRLAEALDGADLVVSSAEAKPYSRKPYAPFMTSTLQQEAGRKLRFTSERTMRVAQRLYENGYITYMRTDSTTLSQSAINAARSQATQLYGAEYVHPTARQYNRKVKNAQEAHEAIRPAGDTFATPGELHARLDNDEFRLYELIWQRTVASQMADAKGTTLTLRITGVAGTGEECVFSASGRTITFPGFLKAYVESVDEEAGGQSDDAESRLPALAEGQGVTAVELNPDGHSTNPPARYTEASLIKALEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVVGLLEEHFGRLVDFDFTAAMEDDLDAIAGGREQRGNWLSSFYFGGDHGADGSVARSGGLKKMVGDRLDDIDAREVNSIKLFTDAENRDVVVRVGRYGPYLERMVTNPDDPEGDSISQRANLPDDLPPDELTPEVAEKLFATPQEGRSLGTDPATGHEIVAKEGRFGPYVTEILPEPAEEPAPAKKTAKKAAAPKPRTGSLFKSMDLATITLDDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKKGTDSRSLADEDQIFNITLDEALKIYAEPKRRGRQAASAAPLRELGNDPASGKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDERAAELLADRRARGPVKKAAKKTTKKAAAKKTAAKSTAAKKTAAKKTPAKKAPAKKSAAKAVSD
(1803) DNA topoisomerase 1 [Rhodococcus erythropolis PR4]
8
MAKADNGSGQGASGNPRRLVIVESPTKARKIAPYLGKDYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDHDFEPLYVVSPEKKGKVAELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAEDTRELDTDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRVIVQRERERMAFKSASYWDISATLDAGAEASPRSFGARLVSVDGSRVASGRDFGADGKLKGSAVTVLDEAYARRLAEALQGVDLTVSSAEDKPYTRKPYPPFMTSTLQQEAGRKLRFTSERAMRIAQRLYENGYITYMRTDSTTLSESAIAAARAQATELYGPEYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSKLDSDEFKLYELIWQRTVASQMADARGTTLTLRISGTAGTGEDCTFSASGRTIVFAGFLKAYVESVDEEAGGQSDDAESRLPVLVKGQEVTATKLDPDGHSTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVIGLLEVHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGETGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPEPPAEPEPDIVPVSAPEPEEISSGSTKTAVKKAAAKKAPAKKAAKKVAGPKPRTGSLLKSMDLATITLEDALRLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLANEEQMFTVTLDEALKIYAEPKRRGRQASATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKDDDVESISDARASELLADRRARGPVKKKAAAKKAPAKKAAAKKTAAKKAPAKKAAAKKAPAKKDS
(1202) DNA topoisomerase 1 [Rhodococcus equi 103S]
8
MASREKSTADGASGTRRLVIVESPTKAKKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGEPWARLGVNVDHDFEPLYVVSPEKKSKVTELKSLLKDADELYLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAEDTRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRVIVQRERERMAFRSAEYWDISATLDAGADASPRAFGARLVSVDGSRVAAGRDFGPDGKLKSTGVTVIDEAYARRLAEALEGVDLVVSSAEDKPYTRKPYAPFMTSTLQQEAARKLRFSSERTMRVAQRLYENGYITYMRTDSTTLSQSAISAARAQATELYGAEYVHATPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLENDEYRLYELIWQRTVASQMADARGTTLTLRITGTAGTGEECTFSASGRTITFPGFLKAYVESVDEEAGGQSDDAESRLPVLTQGQEVTATKLDPDGHSTNPPARYTEASLIKALEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVIGLLETHFGRLVDFDFTAAMEDDLDEIAGGREQRGNWLSSFYFGDAAAADDSIARAGGLKKMVGQNLEDIDAREINSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPDGDPVSQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPEPAPEPEPDIVPVEAAADGTTKTKAVKKAPAKKAAKKVAGPKPRTGSLLKSMDLATVTLEDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLENEDQMFTVTLEEALKIYAEPKRRGRQASAAAPLRELGNDAATGKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDERASELLADRRARGPVKKKAAAKKAPVKKAAAKKTAAKKAPAKKAAAKKS
(208) DNA topoisomerase 1 [Mycobacterium sp. MCS]
8
MKNWSRIQLADGSPRGGNGGGEPPARRANGSVRRLVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVDVEHDFEPLYIISPDKKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERERMAFRTAGYWDVSAELDASVSDPQATPPTFTAKLNSVDGRRVATGRDFDSLGQVRKPDEVLVLDEAAAGALAAGLQAAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTARQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHAQLDTDEFRLYELIWQRTVASQMADARGTTLSLRIAGDSRDGQSVVFSASGRTITFAGFLKAYVESIDELAGGESDDAESRLPNLTQGQRVDAKELTPAGHQTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFGRLVDYGFTAAMEDELDEIASGTERRTNWLKNFYFGGEHGVGDSIARAGGLKKLVGVNLEEIDAREVNSIKLFDDAEGRPIYVRVGKNGPYLERMVADEENPGELKPQRANLKDELTPDELTLELAEKLFSTPQEGRTLGVDPETGHEIVAKDGRYGPYVTEVLPAPPEEPEDGAPAKKGKKPTGPKPRTGSLLRTMDLETVTLDDALKLLSLPRVVGVDPNTGEEITAQNGRYGPYLKRGTDSRSLATEEQMFTITLDEALKIYAEPKRRGRQGAATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPVKKKAAAKKAPAKKTAAKKTAAKKASAKKA
(1070) DNA topoisomerase 1 [Rhodococcus opacus B4]
8
MAKGDNGSAQGAAGASGQPRRLVIVESPTKARKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDQDFEPLYVVSPEKKSKVTELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAEDTRELDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVQRERERMAFRSASYWDISATLDAGADASPRSFGARLVSVDGSRVATGRDFGSDGQLKTSTVTVLDEARAQRLAESLAGVDLTVSSAESKPYTRKPYAPFMTSTLQQEAGRKLRFTSERTMRIAQRLYENGYITYMRTDSTTLSSSAIAAARAQATELYGAEYVHDTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLDTDEFRLYELIWQRTVASQMADARGTTLTLRITGTAGTGEECTFSSSGRTITFAGFLKAYVESVDEEAGGQSDDAESRLPVLVEGQAVTATKLDPDGHTTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVIGLLEMHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGDHGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPEPEPEPEPAVVPVTDESGDGTTKTKTAAAKKAPAKKAAKKATGPKPRTGSLLKSMDLATVTLDDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATEDQMFTVTLDEALKIYAEPKRRGRQAAATPPLRELGVDSVSEKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDARASELLADRRARGPVKKKAAAKKAPAKKAAKKTAAKKAPAKKAASKKAADKKA
(1127) DNA topoisomerase 1 [Rhodococcus jostii RHA1]
8
MAKGDNGSAQGAAGASGQPRRLVIVESPTKARKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDHDFEPLYVVSPEKKSKVTELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAEDTRELDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVQRERERMAFRSASYWDISATLDAGADASPRSFGARLVSVDGSRVATGRDFGADGQLKTSTVTVLDEARAQRLAESLAGVDLTVSSAESKPYTRKPYAPFMTSTLQQEAGRKLRFTSERTMRIAQRLYENGYITYMRTDSTTLSSSAIAAARAQATELYGAEYVHDTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLDTDEFRLYELIWQRTVASQMADARGTTLTLRITGTAGTGEECTFSSSGRTITFAGFLKAYVESVDEEAGGQSDDAESRLPVLVEGQAVTATKLDPDGHTTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVIGLLEMHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGDHGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPEPEPEPEPAVVPVTDESGDGTTKTKTAAKKAPAKKAAAKKATGPKPRTGSLLKSMDLATVTLDDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATEDQMFTVTLDEALKIYAEPKRRGRQAAATPPLRELGVDTVSEKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDARASELLADRRARGPVKKKAAAKKAPAKKAAKKTAAKKAPAKKAASKKAADKKA
(1014) DNA topoisomerase 1 [Mycobacterium abscessus ATCC 19977]
8
MRRLVIVESPTKARKIAGYLGDGYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIVSPDKKGTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPKVPVRRMVFHEITEQAILAAAQDPRDLDNNLVDAQETRRILDRLYGYEVSPVLWKKVGRNLSAGRVQSVATRIIVQRERDRMAFRSAGYWDLGAELDAGKDNPAAKPPRFHARLVSVDALRVASGRDFDSLGQVKETSNGPGVLVLDETRANALVAGLSQATLTVVSAEEKPYTRKPYPPFMTSTLQQEAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSDSALQAARSQAAELYGNEYVHPSPRQYTRKVKNAQEAHEAIRPAGETFKTPGQLHSSLDNDEFRLYELIWQRTVASQMADARGTTLSLRLAGTATSGEQVVFTASGRTITFPGFLSAYVETVDELSGGEADDEERRLPQLRQGQSVTVAELSADGHTTNPPARYTEASLIKALEELGIGRPSTYSSIIRTIQDRGYVHKRGSALVPSWTAFAVIGLLEQHFGRLVDYDFTAAMEDDLDEIASGNERRTNWLNAFYFGGDHGVEGSVARAGGLKRLVGVNLEEIDAREINSIKLFDDDQGRPIYVRVGKNGPYLERMVADPDGEAGALIPQRANVKDGVTPDELTVEMAEQLFAIPQEGRTLGVDPETGHEIVAKDGRFGPYVTEVLPAPPEPVEAEKPKRGAKKVEGPKPRTGSLLKSMTLETVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGTDSRSLATEGQIFTVTLDEALKIYSEPKRRGGQAASAAPLRELGVDSATGKPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDERASELLADRRARGPVKRAKKAPAKAAKKAPAKKAPAKKAAKKAT
(1075) DNA topoisomerase 1 [Mycobacterium ulcerans Agy99]
8
MADPKTKGPGSRSSGGNGSGRRLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSELKDLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRRASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSLWIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPLARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDAESGHEIVAKDGRYGPYVTEILPEPPAPEAGTEAPAKKSKKATAPKPRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKAMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA
(414) DNA topoisomerase 1 [Actinoplanes sp. SE50/110]
8
MPSDARTTRLVIVESPSKAKTIAGYLGPDYLVEASVGHIRDLPKNADEVPAKYKGQPWARLGVDVDNGFHALYVVSAGRREQVAKLQRLAKEVDEIFLATDEDREGEAIAWHLIETIKPKVPVKRMVFHEITKPAIQAAVANPRDIDRSLVDAQEARRILDRLYGYEVSPVLWKKVMRGLSAGRVQSVATRIVVERERQRMAFRSAEYWDIQALLAVQGPVDGPRNFSATLIALDGDRIASGKDFEPTTGQLKPGAAVVQLDGDGARGLAARLADRPFTVSRVEEKPYRRRPYAPFTTSTLQQEASRKLRSSSKQTMSTAQSLYEKGYITYMRTDSVNLSETAIAAARRQIAELYGANNVPPQPRRYTTKSKNAQEAHEAIRPAGDNFRTPGEVAKELNTAEFKLYELIWRRTIASQMTDAIGNSISVRIRAVSTANEEADFAASGKTITDPGFLRAYVESSDDENAEAEDAERRLPNLVKDQPLTADELNALGHHTSPPPRYTEASLVKMLEELGIGRPSTYTSIMQTIQDRGYVEKRGQAMIPTFPAFAVVGLLENHYGRLVDYNFTAAMEGQLDDIASGDHTAVDFLTSFYFGSQAGGADEEIAKAGGLKKMVTEDLSAIDAREVNSIPLFTDDQNRQVVVRVGKFGPYLQRSNTQVADGAEEASEDRASIPEGVAPDELTREKVEELFLAGNGDRTLGDNPATGEPVLVKSGRFGPYVQSGESKSSLFQSQSPQTLTLEQALQLLSLPRVVGKDPEGNEIIARNGKFGPFIQRLKDSRSLESEERLFTVTLDEALAMLAAPKVRGQRGAPKPPLRDLEGVDPVSEKPLLVKDGRFGPYVTDGETNVTLRRGQTPEELTLQEAIEMIAEKRAKGPAPKKAPAKKAAPAKKAAAKAATPAKKATAKKAAPAKKAAPRKAAASSE
(1743) DNA topoisomerase 1 [Salinispora tropica CNB-440]
8
MPSNTGTTRLVIVESPAKAKTISGYLGPGYVVEASFGHVRDLPRNAADVPAKYKGEAWARLGVDVDNGFHALYVVSSDRRQQISKLTKLAREVDEILLATDEDREGEAIAWHLVETLKPKVPVKRMVFHEITKPAIQAAVANPREIDRDLVDAQEARRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERQRMAFRTAEYWDILATLAGEQPGEGPRTFNATLVALNGDRIATGKDFEPTTGRVRPGAGVVHLDEGGARGLAARLADRPFTVTRVEEKPYRRRPYAPFITSTLQQESARKLRFSSQQTMRTAQRLYENGYITYMRTDSVNLSETAIAAARRQIVELYGERSVPPEPRRYTGKVKNAQEAHEAIRPAGDTFRTPGELRNELSVEEYKLYELIWRRTIASQMTDAVGSSVSVRIRAVTAAGEEADFGATGKTITDPGFLRAYVESSDDENAEAEDAERRLPHLVKDQPLTGEQLAAQGHHTQPPARYTEASLVKALEELGIGRPSTYASIMQTIQDRGYVAKRGQAMIPSFLAFAVVGLMERHYPRLIDYGFTASMENELDEIAGGDHAAVDFLTAFYFGITNGAGDQDIARSGGLKKLVTENLSEIDARSVNSIPLFSDDEGRPVVVRVGRYGPYLQRELPGEAAAADGEEGGGQGDRAPIPEGLAPDELTPEKVHELFLGGGGERKLGEDPATGEPILLKSGRFGPYVASGERKSSLLRSQSPDALTLDEALRLLSLPRLVGTDPEGNEVFANNGRYGPYVKRGEEFRSLESEEKMFTVTLDEALALLAAPKTRQRRAPAPPLRELGADPLTEKPLVIKDGRFGPYVTDGETNASLRRGQTPEALSLEQASEMLAEKRAKGPAPRKKAAKKAAPAKKATPAKKATKKAAATKKTAAATKSAKKTATVNSTAAKQAKPKRAGSAAE
(106) DNA topoisomerase 1 [Mycobacterium tuberculosis H37Rv]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(107) DNA topoisomerase 1 [Mycobacterium tuberculosis H37Rv]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(774) DNA topoisomerase 1 [Mycobacterium tuberculosis F11]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASMRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(1617) DNA topoisomerase 1 [Mycobacterium canettii CIPT 140010059]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(929) DNA topoisomerase 1 [Mycobacterium avium subsp. paratuberculosis K-10]
8
MADPKLKENTSGGNGSRRRLVIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPEKKHTVSELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVTPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPTFAARLTSVDGLRVATGRDFDSQGQLRKADEVIVLDEPQATELAAGLQGAQLSVASVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSGSAINAARTQARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSLRIGGQAGDRQVVFSASGRTITFAGFLKAYVETVDELAGGEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERRTDWLNNFYFGGEHGVADSIARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVGKNGPYLERMVTGDDGEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHEIVAKDGRYGPYVAEVLPEPPPDDDDGSGAPAKKGKKPTGPKPRTASLLRTMDLQTVTLEDALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRGNDSRSLASEEQLFDITLEEALKIYAEPKRRGRQGAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQRAAELLADRRARGPAKRTAKKTSRKAPAKKAAKRG
(168) DNA topoisomerase 1 [Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1]
8
MATTPRRLVIVESPTKATKIAGYLGPGYVVESSRGHVRDLPTSAAEVPAKYKGQSWARTGVNVDDDFAPIYVVSADKKSTIKQLKAELKNADELYLATDGDREGEAIAWHLLQELKPKIPVKRMVFHEITPAAIQEAVKHPRTLDEDLVEAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLIVDRERDRMAFRAASYWDIEAILDAGASATPRQFPARLVSLDGQRIAQGSSFDSLGHAKSDVAVLDKPATDALSSALATAPFVVTAVEAKPYTRRPAAPFRTTTLQQEAGRKLGFTTDRTMRVAQELYEDGYITYMRTDSVTLSGQAITAARDAITQLYGADYVPERPRIYNSKVKNAQEAHEAIRPSGEHFRTPAQTGLRGDQFKLYELVWQRTVASQMADATGQQMTVRIEATPTQRVALEGVTPQPVRTAQFTASGRTITFQGFLKAYVESSDKPEQAQARLPQLAAEQKLDAAAINPEGHETKPPARFTEPSLVAKLEELDIGRPSTYASIIRTITSRDYVFKRGSALVPTWLAFAVTRLLEEHFSELVDYDFTAALEDHLDEIAKGDADRLAVLQSFYFGNNNADTHEGLHELTNSLGDIDARALSTFHLGDLGSGIDVRVGRYGTYVQDEEEHRANVPEDMAPDELTVEAARELLAHTGGDERELGLDPTTHLAIVVKAGRFGPYVTEVLPDDDDAPAAKKSKVKPRTASLFRTMDPATVTLDDALKLLSLPRVVGGEGEEQVTAQNGRYGPYLKKGSDTRSLPSEESIFTTTMEQAAELFAQPKRRGRQAAAPLRELGEDPNSGKPVVVKDGRFGPYVTDGEYNATLRKADSVEAITLDRAAELLAEKRAKGPAPKKRTTRKATAKKAAAAKKPAAKKPAAKKPAAKKTASTAKPAAKKPAAKKSASTSTN
(1273) DNA topoisomerase 1 [Microlunatus phosphovorus NM-1]
8
MATTTGRRLVIVESPKKATQIASFLGDGYIVQSSRGHIRDLPTGAAEVPAKYKGEKWARTGVNVDHDFEPLYVVAPDKRPTLRSLKDALSNADELLLATDGDREGEAIAWHLLQELKPKVPAKRMVFHEITPHAIAEAVANPRDLDVDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLIVDRERERIAFRSASYWDIDAILDAGAEAEPPLFASRLVTVGEQRVAQGRDFNSRGALQSKGNEQLVHLDEKAATTLAEALRQADFTVRSIESKKITRRPSAPFRTTTMQQEAGRKLGFTAQRAMSVAQSLYENGHITYMRTDSVQLSGTAISAARHQVRQLFGPQYLPEKPRVYSSKVKNAQEAHEAIRPAGEVFRTPAQTGLTGDEFRLYELIWMRTIASQMRDAEGEQVTIKIDARPRPESGQPQCGFTSTGTTITFPGFMKAYVESTDDASSDDESTRRIPQLHEGQSLRPEEITAAGHETRPPARYTEPSLVAKLEELEIGRPSTYASIIRTITSRDYVFKKGSALVPTWLAFAVTRLLEEHFPKLVDYAFTAEMEDVLDEIAGGRAQRLAVLTDFYFGSKAGAADDREGLQRLVSELGDIDARKLSTFPIGDLESDPGAGGIVVRVGRYGTYVEDGEGRRANVADDLPPDELTVELARELLSKPMGEERELGLDPESHHQIVARNGRYGPYVTEVLPEDAPKSQKPRTGSLFRSMTIEGVTLEQALRLMSLPRVVGVDNDGAEITSQNGRYGPYLKKGTDSRSLETEDQIFDITLDEAKAIFAQPKQRGRAAAKPPLKELGNDPVSGKPMVIKDGRFGPYVTDGEFNATLRRGDEIETITPERAAELLAEKRAKGPAPKKRAAAKKAPAKKAATTRTGTAAAAKKTTTARKTSTTAKKATSARKAPAKRAGSTSSS
(924) DNA topoisomerase 1 [Streptomyces cattleya NRRL 8057 = DSM 46488]
8
MSPTTETAQGGRRLVIVESPAKAKTIKGYLGPGYTVEASVGHIRDLPNGAAEVPAKYTGEVRRLGVDVEHDFQPVYVVNADKKTQVKKLKELLAESDELLLATDEDREGEAIAWHLQEVLKPKVPVRRMVFHEITKDAIQAAVRNPRELNKRLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERMAFSSAEYWDLVGTFGTGRAGDPTDPGTLTARLTSVDGRRVAQGRDFGPNGRLKEGSAVLHLDESAARALAAALADTRFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGMGAKATMQVAQKLYENGFITYMRTDSTTLSETAISAARTQVTQLYGADYLPDKPRVYASKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQYHLYELIWMRTVASQMKDAVGQSVTVKVAGRSADGRDAEFSASGKIITFHGFLKAYVEGADDPNAELDDRERRLPQVTEGDPLTAHSLDADGHSTKPPARYTEASLVKELEEREIGRPSTYATIMGTILDRGYVFKKGTALVPSFLSFAVVGLLEKHFGRLVDYDFTARMEDDLDRIARGEAQAVPWLRRFYFGEAAEGQAGVAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGDGIVLRVGRYGPYVEQAVTGEDGEETSRRADVPDDLPPDELTVDYARELLAKPTGAIELGTDPATGHTIVAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLLKSMALDTVTLEDALKLMSLPRVVGTDPESGAEITAQNGRYGPYLKKGTDSRSLDSEEKIFTVTLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSERPVVVKDGRFGPYVTDGETNATLRRDDDVETITPERGYELLAEKRAKGPAKKATAKKAPAKKAPAKKATAAKKTTAAKKTAAKKTTAAKKTTAKKATAKKATSAAAGTAVATDDGE
(923) DNA topoisomerase 1 [Streptomyces cattleya NRRL 8057 = DSM 46488]
8
MSPTTETAQGGRRLVIVESPAKAKTIKGYLGPGYTVEASVGHIRDLPNGAAEVPAKYTGEVRRLGVDVEHDFQPVYVVNADKKTQVKKLKELLAESDELLLATDEDREGEAIAWHLQEVLKPKVPVRRMVFHEITKDAIQAAVRNPRELNKRLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERMAFSSAEYWDLVGTFGTGRAGDPTDPGTLTARLTSVDGRRVAQGRDFGPNGRLKEGSAVLHLDESAARALAAALADTRFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGMGAKATMQVAQKLYENGFITYMRTDSTTLSETAISAARTQVTQLYGADYLPDKPRVYASKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQYHLYELIWMRTVASQMKDAVGQSVTVKVAGRSADGRDAEFSASGKIITFHGFLKAYVEGADDPNAELDDRERRLPQVTEGDPLTAHSLDADGHSTKPPARYTEASLVKELEEREIGRPSTYATIMGTILDRGYVFKKGTALVPSFLSFAVVGLLEKHFGRLVDYDFTARMEDDLDRIARGEAQAVPWLRRFYFGEAAEGQAGVAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGDGIVLRVGRYGPYVEQAVTGEDGEETSRRADVPDDLPPDELTVDYARELLAKPTGAIELGTDPATGHTIVAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLLKSMALDTVTLEDALKLMSLPRVVGTDPESGAEITAQNGRYGPYLKKGTDSRSLDSEEKIFTVTLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSERPVVVKDGRFGPYVTDGETNATLRRDDDVETITPERGYELLAEKRAKGPAKKATAKKAPAKKAPAKKATAAKKTTAAKKTAAKKTTAAKKTTAKKATAKKATSAAAGTAVATDDGE
(832) DNA topoisomerase 1 [Nocardioides sp. JS614]
8
MAHKLVIVESPAKARTIGGYLGQGYVVESSIGHIRDLPQSAADTPAKIKDKPWGRLAVDVDNGFEPYYVVPRDKKSHIAKLKTLLKEADELYLATDEDREGEAIAWHLLDELKPKDIPVKRMVFHEITKPAIIAAAEHPRELDMDLVEAQEARRILDRLYGYEVSPVLWKKVMSGLSAGRVQSVATRLVVDRERERMAFRVASYWDLEGTFDAGATKEPRMFPAKVHSVDGSRVAGGSDFGPDGLLKAKKGERVHLDRAAAEALVAALAETTYDVRSVEAKPYRRSPYAPFRTTTLQQEASRKLGMSASVTMSVAQRLYENGFITYMRTDSTTLSGGAVEAARAQVRELYGAEYLPDTPRTYTSKVKNAQEAHEAIRPAGDSFRTPAQTGLTGDQFRLYELIWMRTVASQMKDATGQSVSVRIGGVAADGRDVVFAASGRVITFHGFLKAYVEGTEGGKRSDDDQVPLPDLHEGDAVSAASLAANGHETKPPARYTEATLIKELEDREIGRPSTYASIIGTILNRGYVYKKGTALVPAWLAFSVTRLLEEHFPRQVSYEFTAGMEDVLDEIAGGRKDLKSELSEFYYGSDSVVGLKPLVDGLGEIDARELATFPIGGADAGINLRVGRYGPYLEGPDDDGTAYARRANVPDDLPPDELTLDKAKELLANPAGEEIRLGVHPDTGLEVVAKNGRFGPYVTEVLPEDAAQGRKKGAAKPRTGSLFKSMSLDTVTLADAVKLLSLPRVVGVAEDGEEVTAQNGRYGPYLKKGTDSRSLASEDQLLTITLDEALRIYAQPKQRGRAAAAAPLKELGNDPVSGQPVVVKAGRFGEYVTDGEYNATLRKEDSVESITIERAAELLAERRAKGPAKKAAKRGAKKAPAKKAAAKKTATKKAATKKATAKKAT
(114) DNA topoisomerase 1 [Streptomyces scabiei 87.22]
8
MSPTSETAKGGRRLVIVESPAKAKTIKGYLGPGYIVEASVGHIRDLPNGAAEVPEQYTGEVRRLGVDVEHDFAPVYVVNADKKAQVRKLKDLLKESDELFLATDEDREGEAIAWHLQEVLKPKVPVKRMVFHEITKAAIQAAVANPRELNQRLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDASDPASLVARLQSVDGRRVAQGRDFDSVGQLKGANVLHLDEANARALAAALENTRFSVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSETAVAAARAQVTQLYGADYLPAQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKRTVASQMKDATGNSVTVKIGGTASDGRDAEFSASGKTITFHGFLKAYVEGADDPNAELDDRERRLPQVGEGDALSAEQITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTAKMEDDLDRIARGEAQAVPWLKRFYFGEGTGSGGTAAEAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGDGIVLRVGRYGPYIERGEKDAEGHQRADVPEDMAPDELSVELAEELLAKPSGDFELGADPATGHQIIARDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLADALKLMSLPRVVGADAEGQEITAQNGRYGPYLKKGTDSRSLQTEDQLFTITLEEALAIYAQPKQRGRAAAKPPLKELGEDPVSAKPVVVKDGRFGPYVTDGETNATLRSGDSVEEITPERGYELLAEKRAKGPAKKTAKKAPAKKTATKTAAKKAAPAKKTAAAKTAASKTAAAKKAAPAKKAAAKKATSAGESA
(1304) DNA topoisomerase 1 [Streptomyces venezuelae ATCC 10712]
8
MYRHTPQRRERHRPCRCRACQRRTCPESVEPERRAKLSPTSEAAHGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPSGAAEVPEKYTGEVRRLGVDVEHDFQPIYVVNADKKAQVRKLKELLAESDELFLATDEDREGEAIAWHLQEVLKPKVPVHRMVFHEITKDAIREAVANPRELNQRMVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFGTGRSGDASDPSQLVARLAAVDGKRVAQGRDFGADGRLKSESVLHLDEANARALAAALADTAFSVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTILSDTAVSAARAQVTQLYGADYLPEKPRVYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIWKRTVASQMKDATGNSVTVKIGGRAADGRDAEFSASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVAEGDALTADEITADGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTAKMEDDLDRIARGEAQAVPWLKRFYFGDAGGGTAAAGGAADAGNGDGDHLGGLKELVTDLGAIDAREISSFPVGNDIVLRVGRYGPYVERGEKDAEGHQRADVPEDLAPDELTVELAEELLAKPSGDFELGADPVSGNQIVAKDGRYGPYVTEILPEGTPKTGKNAVKPRTASLFKSMSLDTVTLEDALRLMSLPRVVGADAEGVEITAQNGRYGPYLKKGTDSRSLTEEEQLFTITLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSEKPVVVKDGRFGPYVTDGETNATLRTGDSVEDITPERGYELLAEKRAKGPAKKAAKKAPAKKTTTAKKTATKTAAKKTTAAKKTAVKKTTTAKKTTAAKKTAAAKPE
(949) DNA topoisomerase 1 [Acidimicrobium ferrooxidans DSM 10331]
8
MPKPLVIVESPTKARTIRRYLGDEWVVEASVGHVRDLPRSAKEIPQAVKKEPWARLGVDTEHGFRPLYVIPPEKREQVKRLKALLADASELFLATDEDREGESIAWHLLEVLAPRVPVRRMVFHEITERAIREAVGATRGIDRGLVDAQETRRVLDRLFGYEVSPVLWKKVMPRLSAGRVQSVACRLLVERERERMAFRRASYFDVVAEFSRAEAPAPFAARLVALDEARIATGRDFDATGRVATGVVVLDGAHALAVAEAVEGRGGVVRELTERPFTRRPDAPFMTSTLQQEASRKLRFSAQRTMAVAQRLYEQGFITYMRTDSVQLAGEALAEARRLIAERFPGALPDAPRQYRSRVKNAQEAHEAIRPAGTRWRSPDEVAREAPGDEARLYELIWRRTLASQMTDARGMSAVATIDVALGPEVRIDGREIERATFVARGRTLTDPGFLAVYPEQLSEDDEVDLPPLAAGVALTTTGAQPQGHETQPPARYTEASLVRALEERGIGRPSTYAQIISTLVERSYAWRRSQALIPTFLGFAVVQLLERHFAELVDYSFTARLEDDLDRIAIGEEEPTPYLAHFYWGNGAPGLHQLVTERLGEIDARDVNSIPIGQRADGTPVVVRVGRYGPFLQAGEETASIPEDLPPDELTLERAEELLERGRLGDRVLGELDGQPVLLRTGRFGPYVQLGEGDDRSLRRASLLPGQRVETLSYEDAVALLSLPRLVGVDPESQQEIWAHNGRFGPYLAKGRDTRSLDKPEQLFTIDLTEALARFREPKRRGRSASVLELGTHPDTGARVVVRSGRYGPYVSDGEVNASLPRGVDPASLDLDTAVELLAERRARLGSGS
(1797) DNA topoisomerase type IA central domain protein [Eggerthella lenta DSM 2243]
3
MKLVVTEKNDAAQKIADLLGVKKPKADKVYSTPVYRFDVDGEEWVTIGLRGHILEPDFAPTMVYKKRGGWQGVTEEGETLPAELPASLPKPPFKKKKPFTEDGVELKSWKMDALPYLVYAPINKLPKEKEIIRSLKNLAKKADSVIIATDFDREGELIGSDALSCIQEVNPTAPVSRARYSAFTKEEITHAFDNLVELDVNLASAGASRQDIDLIWGAVLTRYLTLVKFAGYGNVRSSGRVQTPTLALVVARERERLAFVPEDYWVIRGAFGADPDSFEAPHATARFKAEAEAQAVMAHVEGATRATVASVEKKKRTVQPPAPFNTTSLMAAASAEGLSPARTMRIAESLYMDGYISYPRVDNTVYPSSLDLADTVKAISGNPAYAPYCKELLAKGKLTATRGKKETTDHPPIYPTAKATPDDLAPADYKLYNLIARRFLATLSEAAVIEGTKVTLDVNAEPFVAKGDVLVKPGYRAIYPYGLKKDEQLPALSEGETVAFNGAVCTKKQTEPPARYSQGKLIQEMEKLGLGTKSTRHAIIERLYAVKYCMNDPIEPSQLGMAVCDALDKFAPHITHPEMTAELEEEMDNIAEGRTTKAQVVDTSRNLLSEQLASLLPHSEEVKEALADAVAADAYVGPCPKCGKDLQLRASQKTRSMFIGCAGWPDCDVTYPLPKGKVEAVPEPCPTCGMPQVKVTAFRSKPRTICIDPHCSTNQEPDVVVGECPACKEKGIQAKLIAQKNPRTLKRFIRCENYDDCGTGYPLPQYGALTATEEVCEHCGAPMVIVTTARGPWKLCPNFDCPGKEQKEDEKGAKGAKGTAAKKPAAKAPAKKPAAKKAPAKRAPAAKKD
(327) DNA topoisomerase [Eggerthella lenta DSM 2243]
7
MPTLIIAEKPSVARGIADAVGAHERRDGYIEGGGYLISWCRGHIIDLDFPQNYPQWSGHWSMSQLPMIPERWRWSVTAPEQYKVLKGLLDRADVELVVNACDADREGEGIFRRVWTHSGCKKPVRRFWSTSLVPEQVRTDLAHAKPLSDYDGLADAAEGRAKADWLVGLNASRALSCLYEGSRLSAGRVQTPTLALVVERTRAIRGFKSVPFFQVECSVGRTAHVRLAGEKLKTRQEALRRAHAAVGSQCAILKVERRQEKCRAPKLYDLTGLQRDASTRAGLTAEETLNALQTLYEKKLATYPRTESRYIGESDIPETARVLSAIAVPGIVGEAAAAGFDASRSDVARVADDSKVHGHGAILPTALLDAKEMAKLDGAERSVAILICCRLMAATMDPATKLKTKVEGEVNGDAYTASGSTVTDASWIAVDEACRAALAGGGKAAEDEDDEAQDIPADIEQGDSFTVADGDVRVKDGKTTPPKPYTDATLLSAMEHAGRSIEDRELKAAIEDDSMHSGGLGTPATRARMIEKLIEAKYIRRRGKTLSATERGETLIDIVCDSLKTPELTAKWELALSHVERGEGSLSDFLSGIEGYTAAVVSDLERGFDPAQAAAVSGREELCRCPACGAPIVLSRSGRQWQCSSSKWAGKEEGWRLLQGCGVKLNIVQNGRKLTKSQAKSILSGGTVHLTGLSKKAGSGTFDTDAKLGAAPYTGFVEFCRSEKPGGSAGRTGSRRRGGKR
(944) DNA topoisomerase type IA central domain protein [Atopobium parvulum DSM 20469]
3
MILVVTEKNDAAQQIARLLSESGKPEADKVYNTPVYRFRRGGEDYVAIGLRGHILQPDFPLALKFDKEEGWYGETAEGEHLPADVPDGLERPPYKVKRKPFMADGVDLKGWKIPSLPYLIWAPVDKQPAEKEIIRALKNLAKKAESVIIGTDFDREGELIGSDALAQVLSVNPNLAVFRARYSAFTKTEIETAFNNLVDLDYNLAAAGESRQYIDLIWGAVLTRYLTTARFGGLGNTRSAGRVQTPTLALVVERERERLAFKPEDYWVISGVASPEDDDEATFKMVHQTARFWDQAEADTVYDVVKDQTQATVVEIESRSRKQQPPAPFNTTSLQAAAAAEGISPARTMRLAESLYMDGLISYPRVDNTVYPSSLDLKDCVRTLSAVPQYAPTCKKLLGQPKLHATRGKQESTDHPPIYPTAAANPDSLQPAAWKLYNLIARRFLATLMGPATMSGTKITLDVAGQPFVANGTVLAEPGFREIYPFGLKKDDQIPDVGEGEIVSIKSLSLDAKQTEPPARYSQGKLIQEMEKRGLGTKSTRASIIDTLYQRKYLKNDPVEPSQLGMAIVDALSQFAPHITSPDMTAELESDMTSVAEGKDTRDGVVTHSRSLLAGMIDVLIDHKEDLSEAIADAVTADAKVGTCPKCGKDLVAKSSLKTRGSFVGCMGWPDCDVTYPLPQGRVEPLEGEAGVCPECGAPRVKVQPFRQRAYETCINPACPTNSEPDLIVGECPTCKANGKHGDLVAHKSERTGKRFIRCTNYEECETSYPLPARGKLEKTDEVCPDCGAPMVVVTTQRGPWKLCPNYDCPGKEKKTAPRRGARKSTKSTKSTKAAKK
(1841) DNA topoisomerase 1 [Petrotoga mobilis SJ95]
1
MPKKSTKSKGNSEESKYVVIVESPSKAKTIERYLGKEYKVIASKGHIRDLPKKEFGVDIEHDFEPIFQVIPGKEKVIQEIKKETKGRKVLLASDMDREGEAIAWHLSQILDLDPKEKNRIIFSEITKNAIKNSISNPQSLDLKKVDAQIARRILDRLVGYKISPLVWKVLKDYKTSAGRVQSAALKLIVDKERKIFIFKPKKYFNIYLEYKGQNIPLTKEDGKKIKPESITKIKKDQIFEYLKDKDFKLVNVEEKESIRKPPLPFITSTLQQAAVSTFNWASSKVMKIAQELYEGVETSEGSIAFITYMRTDSTRVSNEAQQAAINYLEKNYGKDYVGHYLSKNKKSNVQDAHEAIRPTDINMDVNNAKRLISSDHLKLYTLIWNRFMASQSAPSRYLEKTYTIEDNTNKYAFEITSKKCIFDGFEKFWNPNNKEVNFEIGKNDKITYDQLKFEEKETNPPNRYTEATLIKELESKGIGRPSTYATIISTLLQRKYVSKIAKSTLRPTTTGFVVTDFLETYFPEIVDVKFTANMEEDLDKIEDGKNKSKVVLEQFYKEFETFLSTASNNIKNKKEILHYESDVPCEKCGKNMKLNFGRYGLYLSCEECKETQKIPAESFGVTIKEKLYIKEYLQETLKIDKEENKIDEKCPICGGDLILKHGKFGEFIACSNYPECKYTRNVKARGKCPNCGGDIVKLKSKKGKTYFKCNSCSTMYWNEPSEYSCPNCGETLFYKTSKGKEKLYREKDKAYFDIEEIKQLTK
(256) DNA topoisomerase 1 [Marinitoga piezophila KA3]
1
MPKTAKKIVIVESPAKAKTIEKYLGSEYKVVASKGHIRDLPQKKFGVDIEKDFEPEFELMPGKEKVVEDLKKIAKGKTVYLAPDMDREGEAIAWHLSYLLGLDENEENRIIFSEITKNTIQEAIKSPRKIDKNKVGAQLARRILDRIVGYKISPILWRILKDYNTSAGRVQSAALKILVDRERQIFKFKPKEFYKIFLKYMEQDIPLVKIDGKKFKKESISEKKKEEIFKELENAIYSVTAVTEKETKKNPPQPFITSTLQQSAISKYGWSSQKTMQIAQKLYEGIETKEGPIAFITYMRTDSTRISEDAMKKAHEYLESNFGKEYTGHFKVKKSKKKIQDAHEAIRPTDVFMDPKKAKELISGDALKLYTLIWNRFMASQSAPSKYIEKTYTISDNNKKYEFEAVGRKRIFDGFEKFWSSSTTEKEYEIPEKGILENIELKAERDETKPPSRYTEASLVKEMESKGIGRPSTYATIITTLLNRKYVIKEKNSLIPTLVGFVVSDILEMNFPEIVDVKFTAHMEENLDKVESGEMDWKTLLKEFYAEFEKFLNDTDKKLKERSMDFTYNTDISCEKCGEKMQLQFGRYGLYLKCPKCGENKGIQKGALGVTIDKKVYLDESFLKTEKGKEEGIGRQCPKCGGELVIKSGRFGKFIACSNYPECKYTEPLPARGKCPKCGGTVHKMKSKKGKVYYKCSECGEMFWDEPSDYRCPSCNGPLFYKRKNREEMLYCPEEKKYFKESEINEL
(1625) DNA topoisomerase [Fretibacterium fastidiosum]
3
MRLFIAEKPSLARAIAAVLPQPQRASRLYIEAGNDVVAWAAGHLLEQAMPEQYDEKYKRWNLADLPIIPEEWKMLVKKESRDLFDNLKTLLKKADSVVNAGDCDREGQLLIDEILEHCKYKGPVQRILISDTNPDAVKKALAELKPNEDFRGDRDAARARSQADWLHGMNMTRLYTKLAEKNGYDGGPLRIGRVKTPVTALVVRRDLEIESFVPKPYWTLQAQIQVKEGAFWAGWRPKEEQTGLDEEGRLVDKATGEELASRLKGKPAVITKYESKKQSVKPPLGYSLPKLQMAASRKHDLSPSRVLEVCQKLYEQGVLTYPRSDCEYLPEGHQDEAEKVLAVIDALSSLKRPDELNTARKTPVFNGKKVEEHHAIIPSASCRASKPLEGDEPLIFELVARRYLVFFMPDHEYMQTSITAEVEGETFVASGRRVLAEGWKAVERNDEPEKNDDKEDREEEQAALPVVSEGEKGECRDTKLQEKQTKAPARFTEASLLRAMNEVHKFVADPKVKKILRETDGIGTAATQAGILKDLITFGQLQKQKKQLISTPAARSLIQALPEAITLPDLTALWETKFRAIKEGTLSIEDMMEQMATTIRESIAQAGSVSVQGSGEKKPVKATKKTAPKAGKGDVKCPKCGAKMVLRNGKNGPFWGCGNYPTCRATADDDGGKPVFKKQH
(65) DNA topoisomerase