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Taxon : Archaea
Informations
Name
Archaea
Rank
superkingdom
# topoisomerases
196
Lineage and sub-taxa
Lineage
Archaea
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(402) Reverse gyrase 1 [Sulfolobus tokodaii str. 7]
6
MLKVYYTFGCPNCGGPIDDEHLLAGVPCSKCLPGRVENLDYRVIYDLLVKNSTLKGYAEYFYDNETFEEIVRIFKRVIGNEPWNLQKYWIKRLAKSESFSLSAPTGLGKTTTLLVYSLFFSNTTLYVVPTNSLKDQICERLRNMGAKVSCNDVKEEYINVATFNRILRHYDNYVSLQPKLVIVDDSDMILKSGKTTEVMAKILGISEEIFQYAISLIRLKRILKFNEDDKELKNKIVELEYKIGSWKPFVQFLVASATLRPKGIKQQALRTLIGFEPSTIQTYLRNIADLYYQGVDIEAILDKISDNGGLLLVSKEYGREKMLELKEIIEKRGYSTGLAISGRKFLNKFTEGKIDYLIGSASYYGVAVRGLDEPKRLKYVIFYGIPKIRLNLTDALNNPSLIVKIGELLNIDVKDIRRKLLFLSPPEFQILRYSLMKDEELSGKLKDIKVNLINIKEKIWDVLKSDNIKKLKADTFLVTENNGKYYVYIPDTVTYIQASGRSSRIISNGLTFGISIVLVDNIDLLDILSQKLKKIIPNFMFKNINEVDIRELKSLAVSSREVSTSQKKKINIKTILLIVESPTKAKTIARLFGRPSRREVHGIPVYETIILVNDEILITNIIATKGHITDLTTENIGYYGVEVGNNEFNAYYSPIYKCYNCGKTFTIKSNTCPYCGSVFISSSEKVVSALRKLSTEVDEIYIASDPDQEGEKIAYDVAMLISPYNKNIYRIKYHEITRNGILNAILNKGKINMNLVKSQIVRRIEDRWIGFELSLALKSMFYERNHGSGRVQGPVLSWIVERTKEYKKNYGWILYIKLGDYAIKKFFRIKEEANKFIEKLNIKINLISERKEIQNPLPPFTTDSLLMDAYDKLGIGSQIVMKIAQDLFESGLITYHRTDSTHVSALGISIAKEYLESKNLNDSFSGRSWGNEGTHEAIRPTSSMDTESLIKDIEDNPNKYFIKFTKYHLRIYDLIFRRFIASQMKPAEVTYSKFEIFINGEKLEVELPTKISGGFSIIYPLKTYVVSEKYSTYLTKGSIIPLFTYAEIIKNMKEKEIGRPSTYAKTISALIRHGYVVESKRKALLIATNKGIKAYEFLSSCCSDLISENRTKLLLQKIDKIANGDVNVDYVLEDLHKEITQISGKLVNSLKLDTNV
(951) DNA topoisomerase [Sulfolobus tokodaii str. 7]
3
MNCYPKNYILVIAEKSKAAKKIAEALSDKPTTCKKYSVSYWVVNYKGKVNVVAPAAGHLFNLYGDSSFPIFSMDWKPLWEIDDSAKYTKKYYNLLKDLSKYAIEYINACDYDIEGSVIGYMIIKHFGDLKKAKRMKFSALTKQDIQKAYSNLSPLDYNMINAGIARHKVDWIWGINVSRALMLAVSSVTKKRVTLSAGRVQSPTLIHVVENEIARELYIPLPVYRVRVKIKIGNETFSLSLNRTFEYKEEAQEFANKIKKSRAVVDEVRIEEKPLTRPSPFNLGDLQAEAGRILGYSPYYVERLAEELYLDGLISYPRTNSQKIPPSVDIKSIVNGLEANFKNLVGLVRNITKGEYIVRQGSKDDPAHPAIYPTGNRITEKLGIKQYKLFELITRRFLASISRDAIMITQKIIIRFKDVDISDEITRQKIKFKGWLLLYPYHSVKDEELLDVKEGEEVKIESVSVKMDLAKPDVKRYNKVQLLKWMETSNLGTEATRGKIIETLFNRKYLSQKRGTIYPTSLGIVIVEVLKDYFKDLTSIELTSKMEEKLNEILDGKETVEGVVAETINTLRIYLDNYNKYKDQIGIKLAKILGLMKYKKCKFCDLEAEYDNLCKYHYNAYMKLKETLKVWKERTKLEDKDILKKIYSSKTTGKYIKDMISEMM
(1877) Reverse gyrase [Vulcanisaeta moutnovskia 768-28]
6
MEKQPIVIYRKACPNCGGDITSDRLGAGLPCYKCLPEVAKKVANTIEVLNTLEKLGTINRLKSLSNLINEYNEFMNMFKKVVGTNMWGAQRLWTRRLIKGKSFAIVAPTGSGKTTFGMMASLYIALRKRSKVLIVVPTSTLAYDVHRRLSEYSGKMNSNIRIIMASSILYKQELIDAMNAIENGDFDILIITNAFLPRHMDLLRKYRFSLIFVDDVDSVLKASSKNIDRLLLLLGINEEALHKALTVVDLMKKLRKAIRFRASDEEINKLKEDIKKLSTELSNYVKSNNIGILIASGALTRIRRTARLFLFREFLGFETGGRAEGLRNVVDAYTRPKDSLVSAAVEIVKRLGGGGIIYVPPDLREIIDELSEKLNNNGIKAAAYLKPSKSLLNDFVDGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMKFRIKLEEFTPMRYLMFLFNIRNIVPQYLRNDVDRVIARLRNLTALNQEQVNNLLMAIEENRELSGFDKYAADVIKDAVDLVNKLLSDPGIRRAIEQSNEVGLEYRGNDLYVIIPDLTTYIQGSGRTSRLYVGGVSLGLSVLIVDNEKVFNGLVRNLRYRLEDVKVQDINEINIDELMKKIRNERELIRNIMLGRIPNQFLEKDPLRTAFVIVESPTKARTIANFFGVPTRRETGPLVIYEATLGNLYLLITATKGHMWDLIPAAPADVKSFSSFLRSEKLLDYYGILRAGNNFVPIYGTIKRCPVGGETYTEDINVCKIHGAELIDAMDIVNAVRDIATEVDQVMIGTDPDAEGEKIAWDVYMMLRPYVGNIARIEFHEVTKKAIIDAIMNPRTISLSMVGAQLVRRIEDRWIGFGLSQIVQEKFGRRTLSAGRVQTPVLGWIIERYDESRKDKIYTVTMTLSNGIKIRLGIPPDKEELVKTLKALHRNKAVDAVIKVAVTKVGETEEELNPPPPYTTDALLRDSANILGLSVEQTMAIAQELFESGLITYHRTDSTRVSSVGIGIAKEYISEKVSSDYFVGRTWGGKEIGAHECIRPTRPIDSDDLRNLLNTGLLQLAIKVTANHLRVYDLIFKRFIASQMKSAKVMKEKLRISVYFNGVDTHDEEIERISKILEPGFTRFWGYLEGKEYQELTPGEYNVTSIDYIKKVSRTLPLREGDIIAMMKERGIGRPSTYAKIVDVILKRRYALVVGRRTRYVVPTNLGRQVYKFLTEDNKEFSDLVSEERTRMVEKHMDDVEVGERDYMDVLNELFNEAISKGILKENVIS
(322) DNA topoisomerase [Vulcanisaeta moutnovskia 768-28]
3
MIIDSLVVAEKDSVARAIAKYLAQGSISIRRIYGIKAYWFTRDNRQWVSIGLKGHIMNVDFSEELNKWHSVEPSKLFDVEPILVIRGDDLNYVRALTHLGASANTVYLALDADPEGEAIAYEAMFVIRNVNPGAVFKRVLFSAVTRNAIIEAFNSPTNLNPGLAKRVFTRMVLDLTLGAVFTRALTLSVEKIDRKALSRGSFLSYGPCQTPVLNLVVQRALERENFKPEKYYTLHIIVDADGKRIMLDHDGVFKDRQEAEKILNLVRSMAKAKVIIASYKEDFLGPPVPLDTIELERRASRFLNIRPKAALDIAEELYRHGYISYPRTETTIYPPTLSLKQVLLELTHGEHGDYAKTLLGMTIKPTRGNSNDGAHPPIYPTRGVSRQELLRYFKNERYWKIYDLVVRHFMATLSPPARIERQRIVVEVVDHRFSTDGLRMIDKGYLVIYPFESPSEKVLPRVKLGDELSIIKAWVEERETEPPPYLSESELLRLMRKYGIGTDATMQDHIHTNIIRGYFRVRNKQCIPTPLGKAVINVFSKTGGELIDPWFRSRMEKALMEITSGSLRPTDVLFTFKSEARKIYEKFMNRQNEVAMELIKALKESLSKTNRNSNRKVS
(298) DNA topoisomerase 1 [Archaeoglobus profundus DSM 5631]
3
MWLIVAEKDKSARRIARILFKDVKVLKKNQVNYYFSPSNKAFVLGLKGHIVEYDFPEELNNWRRTPLEALLKAKFVVKVKEKNVVKTLLELAKDAERVTIATDYDREGEFIGLTAVKLIQKVNPGVKIERVRFSALTPVDVRRAFENPTSLDLNLAKSAEVRHKVDLLWGAILTRLLSLSANRLGRDFLSVGRVQSPTLRLIVEREEQIKSFKSKYYYNAFVKVRGIYAKRKFEKEEEAKAVLESINTLKVLSFKKSVVEEKKPIPFNTTEFLKEASKFMKPDKAMAIAENLYMEGYISYPRTDNTVYPKTLNLKKLVEMFLSSDFKDHAEFVLKHGIEPSRGRKETSDHPPIHPTAVASKDELSKDEWTIYELVVKRFLATLAPKAKWEVKRVEFEQGFKAMGKKLIFAGWRLIYDYSKPEESYIPDFKVGEVLVVEEKKIKKEKTKPPSRYTTGTLIKVMESLGLGTKSTRHEIIKKLYDRKYIYGNPIRPTNLAFAVINALKETAEVVTLPDMTAKLERDMTAIAEGRIDEKDVLKESVVFLSRILKSVDRERLGSIIKEGIEKDREEEMEKNAIGSCPECGGVLLVKRANKRFIGCSNYPKCKFSRPLPQKGRLVTTSKVCEKHGVKILRIVEKDRKWEFCPLC
(1829) Reverse gyrase [Archaeoglobus profundus DSM 5631]
6
MIPAIYKNLCHVCGNDFDTEEAEKGVCKKKNRIMCRFYEDFIVEEFFKFFEKIVGEPRAIQKFWAKRILRGESFAAVAPTGIGKTTFGSAIALFLALKGRKCYIILPTALLVKQVVENLEKFCEKLDLKAGFNELGDPTILYYHSDIKKDERERFFKLLEEGKFNILVTTAQFLPRYFPQMKHLRFNFIFVDDVDSVLKASKNVDRILQLLGFYYDANEKKWKGKARGCLMVSTATAKKGQKVKLFRELLNFDVGTSTHAVRNIEDVAINSEDINILRQILKKMGTGGLIYARTTEEAEKLYEILKDEFKIGIVTAGRKKDFDLFAEGEIDYLIGTAYYYGTLVRGLDLPERIRFCVFYGAPVFRVRVEDVDTASVGIIKVLAMIFRDNEEVKKFIPYLAVIDKRPEDLEQLKSILKKLIEQGEVKERDIVVRKGEIIFPDIRTYIQGSGRTSRLFAGGITKGASFLMEEDPEIFNAFIERAKFYDIEFKSLEDVDFEKLIKEIDESRERYRRREQFDIIKPTLFIVESPTKARQIARFFGQPSVKVFEENGELQLVAYEVPTPEHVLIVTACIGHVTDLITNMGFHGVITNGKFIPIYASIKRCRDCSYQFTEERDECPRCGSKNVDDSKRRIKALRKLAHDVDLIIIGTDPDSEGEKIAWDLRNLLAGCGEIRRAEFHEVTRRAVVEALKNLRNIDENLVKAQIVRRVEDRWIGFVLSQKLWEVFGDRNLSAGRAQTPVLGWVIQRYEEYKQKKKVAIIRDFDLTLDVEDSKEELELEIELLEEREEERVPLPPYTTDTMLRDANAILKIPAKDAMKLAQDLFESGLCVTPDTYIIMHDGCIKRIDEIFEGEKVLGLNDFHEKDAHVLKFWRIPYKGTIKEITLDNNYRIKATPDHGLFVYRDGKFGWVSAKNIRVGDYVAVAFNTNVERRNDLSLLKLLAELGITDICVEFKENSKLFEKLREKIVGIATSTKYKYLKNRVIPLKYLIEWNVNLQEVEREAKAIYRQRPSAKKIPIFKLNADFWYLVGLVMGDGTVRDGKVAIAQTDVKKVESIVKDILPFIQTWTSGMQVFFANSIIAEILKRLDVRGKLNGLVFSLPEEWINAMIAGYIDTDGCISLMFDKRTGKHNLRIAISSKDREKLEKVGYYLHSIGILNTLHEDKRNGVWTLIVSNRSLKTFKEKIGKYLRIKKERFERAYEVYTNEHKQFESDLVPFGKLFKLLKFKRGIKNKVLKEFGIDVWNWNDCVCIPREKLRKIVELAEDSDIKTFLLELLNANVTWIKVKDVKDRYYNGYVYDVTTTTSNFFANAMLNHNCTYHRTDSTRVSEVGLRIAREFLGDDFVARDWFMEGAHECIRPTRPISKDTLQRLIQEGVIQVEGITSRHLALYDLIFRRFMASQCKPYRVKVARYLIRYDGKEVEEERVLEAEGKAVELYKWCVWVKPALPTGKVKVKAEIRTVPKAPLFTQSDIVRLMKERGIGRPSTYATIVDRLFMRNYVIEKNGRVIPTKRGIDVFNYLASNYGKFVSEERTRLLEEKMDAVERGELDYFKALQELYEEIREIA
(16) DNA topoisomerase 1 [Archaeoglobus veneficus SNP6]
3
MGWLIITEKHNTARRIASILFNDVKQLKKYGVSYYHSPSSNAYVVGLKGHIVELDFPKEYNSWKNVPLRSLLRAELVKEVKEKGIARLLKELAREVDRVTVATDYDREGELIGFEALEIVKQVNPDVKVDRAKYSAITPADIKKAFSNPSKVDINLAKAAETRQRIDLIWGAVLTRLISISSGRMGRDFLSVGRVQSPTLRLIVEREKEIENFRPTPYWEIVAEFCNGECFTAKHVERFTDVAKAKAAFKKIGNTAAVRTFEKKERKEARPTPFNTTEFLREASKFMSPDRAMNVAETLYMNGYISYPRTDNTIYPPTLNLKAIATSFLNSDFEKEAKIVLSQPSIKPSRGKKESKDHPPIYPTAVAKKGELSKEEWTIYELVVRRFLATLAPEAIWEVKRVEIDANGELFRATGRRLLSPGWRAIYIYSKAEEVSIPDLTVGQILRIKNKELLEKETKPPGRYTTGNLIRIMEKLGLGTKSTRHEIIKKLYSRKYVYGNPLRPTQTAFAVIEALKSNAETITLPDMTSKLEKDMDAIAEGKLSDEEVVEESVRFLDEILSNIDVKELSKSLREGVKKDKVVGKCPECGRELVIRKTKGKKRFIGCSGYPACSFTLPLPQNGTLYITAKECEKHSIKKIKIRTKKGYWDLGCPYCNYLEWKAKQDKA
(353) Reverse gyrase [Archaeoglobus veneficus SNP6]
6
MVEAIYAGLCPACGGDLKTSEAKTGKCSRNIPLCRFAGDEVVEEFIEFFRNAIGEPRAVQKFWARRILRGESFAAVAPTGIGKTSFGAAMALFLATKGKKSYIILPTTLLVEQVAESLAKYGEKAGVKVSLNNSDGITVLYYHGRMGKAEKEKFFELIQNADILVTTTQFLSRHFESIKRTFDFVFVDDVDAILKASRNVDRVLMLLGFRKTKKGWEGEARGVLMVSTATAKKGQKIKLFRQLLNFDVGSSTHAVRNIEDIAVEKDDVETIASILEMMGTGGIIYARNTQDAEMLYEALKEKFKIGIVTSGRKKDYELFESGEIDYLIGTAYYYGTLVRGLDLPERIRFAVFVGAPTFTVKLEDVESASPGIIRILALIFRDSEEVKEYLSILPVIDKPEHEKELAELRKILKKLVEEGKAKEKDVVVRKGEVIFPDLRTYIQGSGRTSRLFAGGITKGASFLLESDEEVRNAFVERAKHYDIEFKRMEEVNFEELIKEINESRVAFRRRKEAGDVVKPTLFIVESPTKAKQISRFFGQPSVKAFDGIIAYEVPTAKRVLLVSASLGHVTDLITNRGFHGVEVNGHFVPVYASIKRCRQCGYQFTEERQNCPKCGSEDIDDSKRRIEALRKLAHDAGEVIIGTDPDAEGEKIAWDIQNLLAGCGEIRRAEFHEVTRRAVSEALENLRSVDENLVKAQIVRRIEDRWIGFVLSQKLWKAFGSTNLSAGRAQTPVLGWVIERAEQHREKKVIGFIRDLELSIEGLKAKKARLRIRLIEEKEEEKTPLPPYTTDAMLRDANAILKIPAKEAMAIAQTLFESGLITYHRTDSTRVSEAGMRVAREYLGEDFVAREWFAEGAHECIRPTRAVDKNTLQRLIQENVIAVEDITWRHLALYDLIFRRFMASQCKPYTVRVCRYLVEANGISVEEERVIDARGKAYELYKAVWVRKPLPEGEVEVDVEVRRVPKVPLYTQSDLIQLMREKGIGRPSTYATIIDKLFQRNYVVERNGRVMPTKRGMDVFGYLVRRYAKFVSEERTRILEEKMDAVERGELDYLKALEELYAEIKEITA
(1799) DNA topoisomerase 1 [Thermococcus gammatolerans EJ3]
3
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVSYYEFTRDGKKVIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKNYAKDYIKALATLAKRADEFIVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNLEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVEREKEIQNFKPKPYWVIKMILEKNNSQYTATYEKDKIWDEEEAKRIVSEAKKGPAFVEKVEVKQQKRNPPVPFDLGTLQREAYSAFGYSPKKTLELAQRLYERGLSSYPRTSSQKLPKNLNFRSILQNIAKLPEYKPFAHELLGKGTFKPVEGKKEDPAHPAIYPTGELPKPGELTKDEQNLYDLIVRRFLALFMEPAVRESMRVIINSNGHRFILSGARTLKEGWLKVYGKYVKFDEVILPQFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIKVTPLGMRVVEALEKNVPDIVSVELTRAFEEKMEEIMAGKAKRDEVIEESKEQLIKILKVFKEKELDIGKMLLETTSKDSVKVEKSSEISGTSSRSGASKGENAKSSESSRKRLVLGKCPKCGGDLVLKYNRKTGKRFVGCSNWPKCNVTYPILQRGEVIPTGKTCCNGAPVVKIREKGREYEICLDMNCKEWKK
(488) Reverse gyrase [Thermococcus gammatolerans EJ3]
6
MKALYREMCPNCGGRISDERLYMRNPCESCLNEPIVVDSYFELVSAVRDALLKANRLKEWERIYRLESESREIEDFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSVYYATKGKKSYIVVPTTPLVIQTIRKVQAIIERTGLDVKLAYYHGNLRKKEKEEMLAKIEGGDYDILITSAQWLARNFDEKLKGRHFDFIFVDDVDAFLKASKNIDRSLLLLGFTEEIIGKAWEIIRLKKQMARYLNGNSEDKNDRLKELNEAIEKLQREIEEFKRKNDIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPSKDVKEHVEELLRKLGKGGLIFVPIDQGLSYAEELVNYLREKGFAVELASSKNKKAVERFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLGEVMDFLDDEDRKTAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENDFHKTVLNVFRELVEFLREVLKKEDVLRRLAEDPFVSLVKEEGKWFIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFTEFKMVPFEELDLEKLLKEIDEDREKVKLVMEGKISSKVKDLVKSALMIVESPNKARTIANFFGKPSKTRIGELVAYEVSVGDKMLTILASGGHMFDLVTNEGYHGVLIEREEDMFKFIPIYDTIKRCRDCGYQFVDWEERGVCPRCGSRNVHDALENVKAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRVEFHEVTRPAIMKAIREARDVNEARVEAQMVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTVELGKDGKDVEPPEYVTVEEVQLEERELNPSPPYTTDAMLRDASTFLKLSAPETMRLAQDLFELGLITYHRSDSTHVSSTGIEIAREYITSELGEEYFKPRPWGEEGTHEAIRPTRPIDTGRLMQLIRDGVIQLPRNLTRNHYRLYDMIFRRFMTSQMVPAKVLYEKAVINAGVGKVELEGYVEILKDGWTKLRSPPMRQLPKLEQGAKLKVVESKKWKAPKVSLYTQGDIIALMKERGIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTEKGIKVYHYLVSKYRELVSEEKTRELEEKMDLIEEGKLNYLDVLNELYREITCEIKKEGCS
(863) Reverse gyrase [Pyrobaculum aerophilum str. IM2]
6
MEVPLVAYLHSCPNCGGPITSDRLASGLPCRECLPDGAKAGSIKQVITALRKRKALQGLAWVEAYLRGYEEFAEFFKRIVGFEMWGAQRLWARRFVRGKSFAIVAPTGSGKTTFILIATLYSAKQGKRALLIFPTSALAHQAYKKLLTFAERGGVSLKALAYHSLLTEREKKEALEALERGDFDVLVTTSAFLPKRFELLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDAVLNTALEVINLTKQLRKAEVAGDLKEVERLDQEMAKLRAKLREEVQRLKLGVFVASGALAKARRTVRLLLFREILGFDVGGRAEGLRNVVDLYVEASDNVIEQTLALVKRLGPGGIIYVQDRELGEAIVERAREAGLAVEHFFRPRRGVLESFERGELAALVGLASSRSALVRGIDLPHVIRYVIFVGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLAGDARYKADRLIGQLKRLAPYALSVQEALKKASEGAELSSFDRHAVDVVKSAVEFVNSLLQNEEIRKAIETSSEVKLAYIDGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDPKVFHALKRELSLRFDEAEFKHLGEADLDKILADVDRDRKTIRDIMEGRLVPAARGVDLMRTILMVVESPTKARTIANFFGRPSLIISEGIPIYEVSTGDAVLMVTASLGHIYELPTSLNKIDQRQREVLAKWFGDFKHGNYDGENYAVIVKEYGFVPVYNKIWRCRGAVYVDDIDIPPGCKPLDVLEAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVQDIRRVEFHEVTRRAILNALANPRGVNFSLVKAQIVRRVEDRWIGFGLSKILQANFKNPNLSAGRVQTPVLGWIVNTYEESLKNRVYNVELQLNDVDIRLQVPRDVLDVLRKKKRVAIKLVARERRQVNPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGIAIAREYIVRKFGEGVFKPRSWGEAEEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQLTKSHYQLYDIIFRRFMASQMEPSVVEVAKYNVEIDGHVIQLERTVGVAYMGFQTLYQLTPVEPELPTGTLDVVIKRYRVVRRVLSQADVLALMRQRGIGRPSTYAHILQVLAKRYYVYVTGRTKLMIPTKRGREIFRFLKEAFGKLVSEDRTRLIEQYMDAIEVGKARYEEVIAELYDEFRKEVLPHLAS
(207) DNA topoisomerase (TopA) [Pyrobaculum aerophilum str. IM2]
3
MKLIVAEKRSVAQSIAKFLGRSYKSQKLYGVSVYRFNYGGGEAVAIGLSGHIMDFDFAARQNVWTWLPPEELFNATPILVLRGETLKYVKALKSLATKADEVYLALDADVEGEAIAYETALVVKMVNPRARLYRVRFNAVTYKEIVSAFQKPTYIDLKKVEKVFTRMQVDLTLGAVFTRFLTLTVRNSLNKGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKAVVEIGSSKVEMSADAKFKTKGEAEAIAATIKRGVVKIAVYKPHYVEPPEPLETVELERRASRWLGINSKKTLDIAEELYRAGYISYPRTETTIYPPTLDLKEVLEELTAGEHGPYALELLRKGFKPTRGDSDDGAHPPIYPTKGATRAEIFKVFGKAGGHAWAVYDLVVRHFLATLSPPALVEKQKIVVSFGKIELSAEGQRTIDEGYWRIYPWERQPEKPLPRVAPGEPARAVEIRVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIYTNIKRGYVKLVKGKCIPTALGISLATSLFQYAPELIEPTVRAKIEKSLNSIVKDGVSPAKLIAEIKLEFSKYYQNLKAKREEIKKALETALYSIQQQSRG
(898) DNA topoisomerase [Pyrobaculum calidifontis JCM 11548]
3
MKLIVAEKRSVAKAIAQFLGGSYRAQRVYGVPAYFFNYGGEAVSLGLMGHIMDFDFAARENVWTWIPPEQLFHATPLLVIRDEAAQYVKALQSLARRADEVYLALDADVEGEAIAYEAAIAVRAVNRRARLYRVKFNAVTPKDIRAAFQKPDTLNLKLVEKVFTRMQIDLTLGAVFTRALTLSVRNSLEKGQFLSYGPCQTPVLGIVVNRELERINFKPEKYYVIKAVVDIGGHRVEMGSEVRYKTRAEAEAAASLIKRGVVKAAVYRPHKVEPPEPLETVELERRASRWLGINSKKTLDVAEELYRAGYISYPRTETTIYPPSLDLREVLQELAKGEHGEYARGLLKAGFRPTRGDSDDGAHPPIYPTKGATKDELYRRFGKAAAYAWPIYDFVVRHFLATLSPPAVVEKQKIVVSFGKIELEAEGQRTLDEGYWRIYPWERQAEKPLPVVKPGEAAYAVKVSVVERETQPPPPMTESELLALMKKYGIGTDATMQDHIHTNVKRGYMRLQKGKCTPTPLGMALATALFQYVPELIEPTVRAKIERALNSIVRDGVPPAKLAAEVKAEFAKYFEKLQQHRREIKEALEKALNSSP
(632) Reverse gyrase [Pyrobaculum calidifontis JCM 11548]
6
MDIPLVVYLHSCPNCGGPVTSDRLAGGLPCRECLPEVVKAGGIADVVRALRRRRALKGLAWVDEYLRRYEEFSSLFKAAVGFEMWGAQRLWARRFVRGRSFAIVAPTGSGKTTFILVATLYAAREGKRALLIFPTSALARQVHQRLLSYAEKAGVSVRAVAYHSLLTEKEKKEALGAVEGGDFDVLIVTSAFLPRYFDLLKRFKFDFVAADDVDSILRATSKNIDRILRLLGVSDEVLKLALDVINAVKELRKAEIAGDLKEVERLDAEVTALRAKLQEEARRLKLGIFVASGALARARRTTRLLLFREILGFDVGGRAEGLRNVVDVYVEQGKDVVGQVVELLKRLGPGGIVYVQDRELGLAIVERAVGESLAVEHFLRPRRGVLERFERGELAALVGLASARSALVRGIDLPHVIRYVVFVGVPKYKFRVRLEEFSIPAYLTFFYNVRAVLSGELRYKVDRAIGQLKRLAPYALSVQEALKKAAEGQELSSFEKHAVDVAKGAVELANSILSDEELRRAIDSSTEVRLAYIGGELYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVVDDWKVFTALQRELKLRFDEAEFKRLDEVDLSAVLAEVDRDRRTIREIMEGKAVVTGGRELMRTLLMVVESPTKARTIANFFGRPSMLLVDGVPVYEVSTGDAVLMVTASLGHIYELPTSLDRISKEEREVLRRWFGDFRRGDYDGGEYAVLATEGGFVPVYNKIWRCRGAVYVDDVDVPPDCRPLDVLAAIRNLAVEVDAVLIGTDPDSEGEKIAFDLYLGLRPYVADIRRVEFHEVTRRAIISALANPRGIDYSRVKAQIIRRIEDRWIGFGLSKILQREFGSPNLSAGRVQTPVLGWVVTTYEESLRQRMYNVELQLDDVDLRLQLPQEALKALRERRRVAIRKAGAETRVVNPPPPYTTDELLRDAVNRLGLSADYAMRIAQDLFESGLITYHRTDSTRVSAAGIAVAREYITKRFGEGAFRPRTWGEEAEGAHEAIRPTRPIDVEELRGLVNAGVLQLAIRLTRSHYQLYDLVFRRFMASQMEPSEVEVERYEVEIDGYVAQVERVVDIKRQGFQVMYQVTAVEPGLPTGTIEVTVKRYRVIRRILSEADVLALMRQRGIGRPSTYARILQVLAKRYYVYVAGRRRLMVPTKRGIEVYHYLEQKFGKLVSEDRTRLIEQHMDAVEQGKAKFEEVLGELFDEFKTEVLPNLSGASPKS
(471) Reverse gyrase [Vulcanisaeta distributa DSM 14429]
6
MEKQPLVIYRRACPNCGGDITSDRLASGLPCHRCLPDVPKKVASTIEVLNMLEKLGTINRLRSLANLVNEYNEFADMFRKIIGTNMWGAQRLWARRIIKGKSFAIVAPTGSGKTTFGMIASLYVALKRRGRVLIVVPTSTLAYDVHRRLSDYVNKMGVNVRIVMASSILSKQELTEAMKTIEDGNFDILIVTNAFLPRHMDLLSRYRFSLIFVDDVDSVLKASSKNIDRLLLLLGINEEALRKALTVVDLMKKLRKAIRFRASEEEINKIREDIKRLNAELTNYIKSNNIGILIASGALTRMRRTARLFLFREFLGFETGGRAEGLRNVVDVYVRPRDSLISTAVDIVKRLGSGGIIYVPPDLRDIVDELLEALNKNGVKAASYLKPSKSLLNDFVEGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMRFRLRLEEFTPIRYLMFLFTIRNVVPQYLRNDIDRVVARLRNLTALNQEQINNLLKAIEENKELSGFDKYAADVIKEAVDLVNKLLSDPNIRKAIEQSNEVGLEYRGGELYVIIPDVTTYIQGSGRTSRLYVGGVSQGLSVLIVDNEKVFNGLIRNLRYRLEDVKIQDINEVNIDDLMKRIRSERDLIRNIMLGKIPNQFLEKDPLRTAFVIVESPTKARTIASFFGVPTRRNVGPLIIYEATLGNLYLLITATKGHMWDLIPAGPADVKELAPALRAGKIIDYYGILKTGNNFVPIYGTIKRCPVGGETYTEDVDVCKIHGVKLVDAMDIVNAIRDIATEVDQVMIGTDPDAEGEKIAWDVYMMLRPYVSNIVRIEFHEVTKKAIIDAITNPRAISLSMVGAQLVRRIEDRWIGFGLSQIVQEKFGRRTLSAGRVQTPVLGWIIERYDESRRDKVYSVTMTLSNGVKVRLNIPPDKEELIKALKAMHRNKSTDVEVKVRVTKVGEEEEELNPAPPYTTDALLRDSANILGLSVEQTMAIAQELFESGLITYHRTDSTRVSTVGIGIAKEYISERVGADYFVGRAWGGKEIGAHECIRPTRPIDSDDLRNLINTGLLQLAIRVTANHLKVYDLIFRRFMASQMRSARVLKEKLRISIYLNGANVHEEEVERVSKILEPGFTKVWGYIEGREYQELMPGEYGITSIDYIKKVSRTPPLREGDIIAMMKERGIGRPSTYAKIVDVILKRRYALVVGRRTRYVVPTNLGRQVYKFLTEENKEFSDLVSEERTRIVERHMDDVEVGERDYMDVLNELFNEAVSKGILKENVIT
(1660) DNA topoisomerase [Vulcanisaeta distributa DSM 14429]
3
MIIDSLVVAEKDSVAKAIAKYLAQGSISVKKVYGVKSYWFTRGGRQWVSIGLKGHMMDVDFPEELNKWHSVEPSKLFDAEPILVIREDTISYVRALSRLGASASVVYLALDADSEGEAIAYEAMLVIRNANPRAVFKRVLFSAVTKSDIIEAFNSPTSLNPGLAKRVFTRMILDLTLGAVFTRALTLSVEKTDKNALARGSFLSYGPCQTPVLNLVVQRALERENFKPEKYYTLHIIVNVNGVRVTLNHDGTFKDKQEAERVLSLVRGKARAMVIIANYKEDFIEPPVPLDTIELERRASRFLNIRPKAALDIAEELYRHGYISYPRTETTIYPPTLSLRQILLELTHGEHGDYAKTLLGMSIKPTHGDSNDGAHPPIYPTRGVTRQEILRYFKNEKYWKIYDLVVRHFLATLSPPARVERQKIVVEISGHRFSVDGLKIIDKGYLTIYPFESPSEKVLPRVRVSDELSIVKAWIEERETEPPPYLSESELLRLMKKYGIGTDATMQDHIHTNVIRGYFKIRNKQCIPTPLGKAVISVLSKTGNELIDPLFRSRMEKALMEITSGSLKPDDVLFTFKNEARKIYEKFINRQREVAMELIKALKDSLSKGNKGAGGKAS
(165) DNA topoisomerase [Thermofilum pendens Hrk 5]
3
MSYKAVIVAEKNSVARAIASFLGGSSVRRFRVERVPAYEFLWEGGKHLSIGVSGHILDFDFPEEYNKWESVDPRVLFFTNPVLVTREGAYIYVRALKTLARQTSTVILALDADVEGEAIAFEVMRIMKSVNPELEFRRAWFSAVTKSDILEAFRKLREPNENLANKAFARMVVDLTIGASFTRILTLSARRNGGVMPRGSFLSYGPCQTPVLYLVVKRELEREQFKKKKYYVLRVRFRSQEGVFTASATFEDQEKAKSALDSVKRTGVGVVVSAEFNAVEVEPPVPLNTVYLESRASLFLNLRPKETLSIAEKLYSFGYISYPRTETTIYPPTLNLRGIASMFTRWEDAGWYVAKVLAKGFTPTRGREDDKAHPPIYPTRSASREEITRRFGEKAWKVYEYVVRHFLATISENAVVERQRVVVKVGELSLQSEGRKLVYAGFYNVYKYSVPKDEPLPYVVEGEEVEVEDAKIEARTTQPPPYLSESELLALMKKYGIGTDATMQEHIHTNIERRYFVVKNKRCIPTPLGRTLALALYETVPELVLPEVRGKMEASLSKIATGERTPEEVVNEMRSEFLEYYDRLVERIDYVSKKIVEGLKMVFQDEKQQARAGSVGEERSRSTRTHRKGKK
(1767) Reverse gyrase [Thermofilum pendens Hrk 5]
6
MKALYKSLCPNCHGDISDFRLEKRLPCRQCLPEKDAELFLSSETSRAPDPFFEHLERLVKVLGKSGKLLHLEELYSVERDLADFQAFFRKAVGSRPWSAQKTWARRVLRNTSFVILAPTGVGKTVFGIVMALFLASRGKKSYIVLPTTTLAQQVFEKATLFARKVAVNEGGIVVYHGGLPQSKKEEVLSRVSGGDFSVLITTSQFLSRNFDKLERVRFDFVFVDDVDSIIKSSKNIDRILRLLGFTQDEISVALEIIRERVRLARRLRNGASTSDVYERLEELRRKLAEYTGKGGPRGVLVVSTATGRPRGLRIRLFRELLGFEIGSRGELFRNVVDTYVVVDRDEEVVRQVATLASRLGRGGLVFAPAGTGEEFLESLAEALEKSGLRVGRFYGNHNKRKLLEEFSGGNLDVLVGVASYYGTLVRGLDLPHVVRYAIFAGIPHFKFSIKLEDVPPLRLLQIASNVRVVASRDDQAVIDRLVAYVRNWLQNMEPGEYMALTQCLSEGSCHEKYSRLVESINHLRSIVEKYLSSKEYLERLSKETSLTVVSEDGQLKLLLPDVLTYIQASGRTSRLYARGVSKGLSIVVTGNGLLFEKFAKFSRLYSSDIEWKPLSEVDLDLLVREIDEEREIIRRILSGEVSAELAGDLVKSVLVVVESPTKARTIASFFGKPSRRRVGPLVAYDIAFSGYILTIVATQGHIFDLTTNAYSYNSSKDLYGVLVLDAYGASKHYRFVPVFNTIKRCMNCGAQFTEYAVEDVPRQHVQKVEVEKRCPRCGSTNVFDKAEIVEALRKLASEVEEVFVATDPDTEGEKIAWDVYLSLAPYVRVIKRVEFHEVTRRAFEEALRNPRSINDRMVEAQLVRRIEDRWLGFSLSQKLQECRGHKWLSAGRVQTPVLGWIVENSEKARRKKVVFILELSRRGAEGEKLRVIVDNARLDGQSPAAVSNKIKEEGVTVSIVSREEKTLPPPPPFTTDTLLREANQVLGLDVDRTMRIAQDLFESGLITYHRTDSTRVSDLGISVARTYITERFSEEYFAPRRWGEGGAHECIRPTRPLDVDSLMQMIRQGILQVQVNFTRDHIRLYDLIFRRFIASQMPPAKVVEAKAVVKGPYFEKEITFIESIIEKAEGFTKILPLRTRQIPEGKYDVLLSTYKRVSEVPLYTQADVIRLMKERNIGRPSTYSKIVRTLLDRNYVVEVKGGRLVSTRLGKKVYEFLSVNFGDVVSENKTADVLRRMDEIEEGRADYLDVLAEFYEEVQSKVIEKNADCDILTAPNGKHLEDR
(1325) Reverse gyrase [Thermoproteus uzoniensis 768-20]
6
MDFRVLPALYLHSCPNCGGAVESYRLAEGLPCSECLPEEVAGSDIRRVIENLRRRNALRGLAPLADVLRRYEEIANLFEKVVGFRMWGAQRLWARRLAAGKSFAVVAPTGSGKTTFLLISALYMTSRGKALLVFPTSALAYQAYKKLLDYSSRAGLAPRIVTYNTMLKPQEREEALKRIEAGDFDILVITSAFLPKYFELLARHKFAFVATDDVDSVLRATSKNIERLLKLLGATDEVLGKAFELIELGKKRGKAVLAGDEKEAERIEREIEKAREELRRIKAELRLGVFVASGALAKARRTARLLLFREILGFDVGGRAEGLRNVYDLYVKMAEDPKTQVAELVKRLGGGGIIYVLDKDFGKDLVQHLQASGIKAEHFFRPRRKVLEAFEQGQLSVLVGLASPRSALVRGIDLPHVIRYVVFVGIPKYKFRVKLDEFSVPAFLSFLYNVRAILPQDLRFRADRLIAQLRRIAPYSARLDKILKEGASNSFEEYVLGVAKSAVEFVASLLSRDDIRKAIEASTEIKLTYIGEQLYVLLPDVTTYIQGSGRTSRLYAGGLSRGLSVVLVDDEKVLNALIREMELRFDDVRFEELSKADLDGILKSVDEDRENIRRILSGMLKPEELASRDLMKSILLVVESPTKARTIASFFGRPNMLIIGGMPAYEVSTGDSMLTVIATMGHIYELPTNLQRVAEDERRKIWRLVKPVAAGPYSPMDYSVVKTEAGYVPIYNRIYKCPGSSYVDDLDVPEGCKPLDMISTLRELASEVDAVYLGTDPDSEGEKIAYDVYLILRPYVGLIKRIEFHEVTRRAIMNALASPRDVNLSMVAAQIVRRIEDRWLGFGLSRKVQEAHGLAFLSAGRVQTPVLGWIVERYENSKAERKFDVVLKIGDGQIRLALPEDVYKALKENRKARISLLEEKTETIQPPPPYTTDEYMRDAVNKLGISAEEAMSIAQDLFESGFITYHRTDSTRISTTGIGVAREYVARRHGADAFRPRTWSAGEEGAHEAIRPTRPIDAEELRGLVAAGVIQPTIRLTRNHYAAYDLIFRRFMASQMREAEVVVARYALLLDGFNAEVRRVVEVKNEGFLAEYRSVELEPRLPTGEVDVEIAYAKRLVELLSQADVLRMMRERGIGRPSTYAKILEVLSRRGYVVVRGRRKFMIPTKRGIEIYRYLRENYGKLVSEERTRLIEKYMDDVENGRKNYVAVLDELFTEFLQEVLTRQ
(1621) DNA topoisomerase [Thermoproteus uzoniensis 768-20]
3
MLIVAEKRSVAQAIAKYLGGTYSSFKVSGVSAYRFKYDGASAVSLGLSGHILDFDFPQEMNRWGAVDPARLFDEAVVLTPRPETLKYLYALRSLARGQDVVYLALDADSEGEAIAYEVVLQVRVVNPAARFKRVRFNAVTKAEITRAFARPVDLDLKVVEKVFARMASDLTIGAAFTRLLTLSVRREDSSALPFGKFLSYGPCQTPVLGLVVSRELERLNFKPEEYFVVRAVVGTGGGEVEMRSKPFKRREEAEAALAAARKAEGRIAEARYEKAEVRPPVPLETVELERRASRWLNIRAKAALDIAEELYRLGYISYPRTETTIYPPTLDLRAILEELRNTPFGQYAEDLLRRPFTPTRGRSDDGAHPPIHPTRGAGRGEIEARLGQRGWKIYELVVRHFLATLSPPAVVERQRIAAAFGPLVLEAEGRKVISKGYWTVYPYEEEEEEPLPYVKRGDPAELLSAKIERRLTEPPPRMTESELLKLMRKYGIGTDATMQDHIHTNVLRGYMRIAGGKCIPTPLGMSLATALMKHARPIIDPEVRSKMEAALQEIAAGRMDPSKVVAAIREEFKKYYKFLEDKKAEIAGELVKALKEGPDRKQ
(1125) Reverse gyrase [Thermoproteus tenax Kra 1]
6
MDFKTIRAIYLHSCPNCGGAVDSSRLAQGLPCSECLPRALKLENLKSVIQALKSEGSLKELATLDEVLRRYEELNVLFEKVVGFRMWGAQRLWAKRLAAGKSFAVVAPTGSGKTTFLLVSSLYMARGGKVLLVFPTSALAYQAYKKLLDYSARANYSGRIISYNTMLREQEREEALKRIEEGDFDILIITSAFLPKYFDVLAKYKFIFIATDDVDSVLRATSKNIERLLRLLGATDEALNLALDIIELNKKRARQMLGGDEKGLEESDVEIKRKREELRRLKARLKLGVFIASGALAKARRTTRLLLFRELLGFDVGGRAEGLRNVYDVYAKLSEDPRAQVAALVKRLGSGGIIYVQDKDLGRELVEYLKGEGIKAEHFFRPRRKVLEAFERGELDALVGLASARSALVRGIDMPHVIRYVIFVGIPKFKFRVKLDEFSAPAYLAFLYNVRGVLPQELKFKADRLIAQLRRIAPYTAGLEKVLTEGPKNSFEEYLLNVVKSAVEFVGLILSRDDVKRAIETSTEVKLTYIDGQLYVLLPDVTTYIQGSGRTSRLYAGGLSRGLSVILVDDEKVLHALRRELELRFDEVKFYDLAETDLDKILREVDSDRETIRRILSGSFKPEELSARDIMKSVLLVVESPTKARTIASFFGRPNMLIVGGVPAYEVSTGDMMLTVIATMGHIYELPTSLAKIEPSEKERVLRAVGRTLSEIYSPEDYAVFKTEDGYIPVYNRIYKCPGASYVDDTEVPENCQPLDIISTLRNLASEVDLVLLGTDPDSEGEKIAYDVYLALRPYVGSIKRIEFHEVTRRAIVNALSSPRDVNLPMVAAQMVRRVEDRWIGFGLSRRVQEAHGLAFLSAGRVQSPVLGWIVERYQSSRAERKFDVTIELEDGSIRLTLPEDSYKALKSEGRVRIKRLEGREVVLQPPPPYTTDEYMRDAVNKLGITAEQAMAIAQDLFESGFITYHRTDSTRVSATGIGIAREYISKRFGADLFKARPWATGEEGAHEAIRPTRPIDAEELRGLVAAGVIQPTIRLTRNHYAAYELIFRRFMSSQMREALVRVEKYEVEAGGYKAEVERVVEIKEEGFLRMYRTVEEARPLREGESPIKITYAKRHVELLSQADVLRLMKERGIGRPSTYAKILEVLSKRGYVVVRGRRKFMIPTKRGIEVYQYLKSNFGKLVSEERTRLIERFMDDVENGRRDYRAVLDELFEEFIEEVLKR
(1842) Topoisomerase (DNA) III alpha [Thermoproteus tenax Kra 1]
3
MLIVAEKRSVAQAIAKYLATSYSYFKISGVMAYRFKYKDRQAVSLGLSGHILDFDFPQELNKWNALEPVELFDKITVLVPRDETIKYLYALRALARDEDEVYLALDADSEGEAIAYEVVLQVRAVNPRARFKRVRFNAVTKKDIVQAFERPVELDLKVVEKVFARMVSDLTIGAAFTRLLTLAVREVDNKALPFGKFLSYGPCQTPVLGLVVSRELERLNFKPEEYYVVKGIVETEAGSFEARSRPFKAREEAEAAVRAARVSLGKVIEARFEETRVKPPAPLDTVELERRASKWLNIRAKAALDTAEELYRRGYISYPRTETTIYPPTLDLRAVLEELTNTQFGQYAERLLRGPISPTRGNSDDRAHPPIYPTRGATKAEVERALGTRAWKLYEFVVRHFLATLSPPAIVERQRIAVAFGPLVLEAEGRRIIERGYWEIYPYEEEEDRRLPRVQAGVWARMVSAKIEKKKTEPPPRMSESELLRLMKKYGIGTDATMQDHIHTNVIRGYMRIVGGRCVPTKLGMTLASSLMNHARPIIDPTVRSKMEAALQDIAVGRADVKKVLETIRGEFKTFYKGLYEKRQEIARELVKVLREETRNGPRSDV
(75) Reverse gyrase [Staphylothermus hellenicus DSM 12710]
6
MVELKHIHGYYRYSCPNCAGENSDLRLIYKAPCDKCIEEELFDQIRENISKKSYKEILETYYKVLQKHNKLKKRFESLYKFEEKLEKFEEFFSRATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYLSKKQIMIQKNRASRKKVYLVFPTTPLLLQAEKKLRKLAEQARIPVCQEENHDQTCLNIISIHGRVSKKKREKLLEEIKSGNFDILLSTNMFMHRNYELLLGKKYELIVMDDVDAILRSGKAIRILFYLLGLTDQEINEAIEYLKARQRLAFRLSEEKRRELEQKLETLEKRIEKYKRKIGTIVIVSSATGKPRGIYPRLFRILLNFEAGSKAEAIRNIVDTYTYPEESIEQTIIKLAKKLGNGGLIFVPIDKGVEYAETIAELLKKNGINAEAFHAKKAVKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFSTRLETPSPTDVLRIFTILRDVLEGEEKRKAEILIGRISLRLRRLSQGALMKLKEDFIKKLQGEEVEEYPLLSMLIEALSMARELLSKPEIWEKLKQKGDVALIQEDGKSYILIPDVATYIQASGRTSRLYPGGITKGLSIVIVDDQRLLNGLTKRMRWLYEEFDMRRLDEVDLDNLMKEINEERRKVKMILEGKIEAEKTLELTKSALLIVESPNKARTIANFFGKPSIRILENGMPVYDVTTGDYVLSIIASIGHVYDLVVDDGLYNYGVRLVGDKFVPVYTDIKRCNKCGYQFTAETNTCPKCGGRDISRKLDIVETLRELANEVDTVFIGTDPDTEGEKIGWDIKVLLEPYAREIKRVEFHEITRRAILNAIRNPRDFDMKLVEAQIVRRIEDRWLGFALSKKVQKYFWPKYCVEALIPSLYKMIRKKKKKIEKMPNCCVENRNLSAGRVQTPVLGYIIERYRDHNDVSKYKYLLTIKIDDNRLRVDIDRSVLENIGTTSPRDLIGYRVEVLEGDRKEEIINPPPPFTTDTLLEEASMRLGLSTTRTMEIAQELFELGLITYHRTDSIRVSDAGINVAKQYLEEKLGEKAKEVFKPRTWGTGGAHEAIRPTRPIDADRLAELIREGALILARPLTRLHYLVYKLIFNRFIASQMIPAKIVKQILKIRINGYEKNVERVIGIIEKGFLEFYQTVNIEEEVKPGTYPIVDVEELKPPLARYHDVIKWMKIKGIGRPSTYAKIIQTLIDRRYVNVSKRVKALIPTRRGIMVYEEFLNKYYRDVVGVDVTRELEKKMKEVEEGVRDYQEVLWEIYNELRTKIIDNPIVNKELERQWSMYCGQTEYSK
(1720) Reverse gyrase [Staphylothermus hellenicus DSM 12710]
6
MEKILDPIYKNLCPTCSGDVFANSLWDFGVCGKCSGETRNSFNALTLYRAFKEDLEDFTSFFRKATGNLKPWGAQLTWVKRLLNGENTVIVAPTGMGKTTLLVVYSVYVAKNYGKKVLFFAPTRALAKQIYNRIIEAAENVCGTCINILFYDSGLSKKRREEILLKIKNNEYDILVLTNHFLNRHYDLIDPSHIGLIVIDDVDSLMRSSKNILRLMKLLGFHEELIEKAKKRNSIIWKLMLSKSLNKEEDYRRYIEELIEIEAEIDKLLRNTSRKQVVIASATGRMKGTYAKVMRDLLRIDVSGITVYGRNITDTYLLINDYVSDADNIIEVIKILGPGALIFISPRHPLKKKLLELVKLLREKLEERGYRVAEANPSTIKKFIRGEYDFLIGSSSYYGVSVRGIDAPETIKYVLFIGTPLFTVELGSFLASPNMLIRVSLMLSEVLGDQRYRGMASAIRRLVFPLNSGEIKLLSMLLKNKITINDLGKDSRVAKVYEQILGFYNEIRKSLEELLSKKKVVNMNTITFYHADNKFYALIPDVMTYIQASGRCSRLYLGRMTHGLSLVVEYEFLSNLVNGLSLKMNMFSHGFVFKDISNVDLYGERKLIEKTRRELKGPVLTYRNILVVVESPTKAKTIARFFGKPVRRKIGSISVYEIPFVKDSEVIHLNIVATRGHLFDLTTDPSIPNHGVLIEDHRISPVYTSIKRCRICGHQFTYGDRCPRCGSTSFTDSYEVVNVLRKLAQEADEVYIATDPDIEGEKIAYDVYLTIKGFVDKVWRIELHEITLNEFLNALENKRDINRKLVEAEIYRRVLDRIIGFSLSQELWRKYSKKWLGAGRVQTPVLGWIIDHYNEYVSNKCRKIIYITEHKGFKFSICIDLKDKDLYKEMRSVDHVTLVLKNSRIETFNPPPPYTTDELLYDASRIGIPSSLTMKIAQELFESGLITYHRTSYHYVSSAGISVASKYLENKDLMKHFHPSHWGNKGAHEAIRPVHPLDREDLEKAVVEGIVAPTIPLTWLHYRVYDLIFKRFISSQMNPYKALIGEYDVVINNKVVKTLVLPIEIVEDGFNIIMGSKTYSFLKGHDRVNISIKDIKAMVTSTKPLCSEGGLVKLMKEHGLGRPSTYSKIISSIVRHGYVIRSKKRGFLIPTKTGIEVYNYLSNSFPELVSIDTTRDMEMRIDLIAKGEMRAADEISRVLDRIRRYKLPLSIREVVAEASA
(1275) DNA topoisomerase 1 [Staphylothermus hellenicus DSM 12710]
3
MKVKAKKSIIDYILSYSKKQEKEHVKAEEKTLPRKVTEKAKIKITRNIWDLTGKIVVIAEKPKAANKIALALSKNPIRKSIYGIPYYMIKTKNGLIIVASAAGHLYGLHTDQYGYPVFRYEWKPLYQIGHKAKHTKKFITALSKLCSNADYYVNACDYDIEGSVIGYLIIYFHGDLEKSLRAKFSSLTIGELRESFRKLTSLDWEMIEAGLCRHELDWIWGINISRALMSSVKMASGKRVILSAGRVQTPTLRYIVEKDIERRLFIPLPQYSLSINISKNNYEIHVEYKGKAVETKKKAKEIIKDIKNTGYLTVKKYEEKKYWLNPPPAFNLGDLQEEAARIYRFSPYKTQSIAEKLYLDALISYPRTNSQKLPPTLNYKGIMNKLSRINNYKELISNLLVETRGVLKPVQGPKDDPAHPAIYPTGVKPKDLGKDEWKIYDLIVRRFLAAFASRARISHRIVYLEYPKDPSMVFMASGRKILELGWLRYYPFSMPEERFLPRFQHGEKVKITKASIRKTYTKPPEKISRIKILRWMENVGIGTEATRARIIEILFNRKYLRSVGGRVEATDLGLGIIEVLMEYFPEITSVSLTRYFEGEMEKIRLGIRRRDEVVRDAKNTLIKLIVSFDKKKYQIGKTLSYRLGYLTPTNKCMLCNREAYKNNLCKYHYQALNTIVKTYEEWKRREGVDWDKYLSSIKKLKSTGKWIVEVIQNFEKIKYSHSK
(1183) DNA topoisomerase [Metallosphaera sedula DSM 5348]
7
MKLVITEKPSVALDIARALGKPTRRQGYLEVGEYLVTWTYGHLLEIGEIAPKRWNLKDLPIFPEKFEYDLIKGKESQFKVVRKLLEGADAVINCGDAGREGELIVRELLEFTGYRGKVLRLWTSEALTRDVVLRELRRLRPSSEFDSLYYSALARQNGDWIVGINLTRLVTLKAGGGEVWSVGRVQTPTLAMIVKRDREIEAFKPEIYYVVLAGFEGEMKGVMLRNGEEARLAREEAEQVVNALKSVRSGRVEKVDVERREERPPLLHSLTSLQREANTLYGLSAKRTLDVAQSLYEEWKLISYPRTDARYLGEGNRDLVKDVLRKLGRGELVPRVDRVGKRVFDSSKLTDHHAIIPLDRPPENLPAIHRKVYDLVYRKFVGAFMDDYVYELQRVFIRLDGELFLVEGKRNLQLGWMELYPHEDNPLKIPSGEVRKEWVKAEERQTKPPARFTEASLLREMERLGLGTPATRAGIIETLLERGYVERRGKSLYSTDKGRELVDKLGDSKVVSPDMTAEWERQLEEIYVKRLGEKGYQEFMEGIRRFTREEVERLMKREFKVERRATPEMLRLARAVSRDLGVKLEGTGMEEVKRFLDENLPKMRITCKCGGEVVGFSRGWKCRKCGTVVWREIAGKKITFRQAKSLFQGKELKMKGFRSRTGKRFSATVYLEDGKVKFKFE
(1748) Reverse gyrase [Metallosphaera sedula DSM 5348]
6
MITSVFHSSCPNCQGPLEDYRALAGLPCTSCMPGSVDSFKDLPQEEKIKVVYNILVNNGKLGKYWELYYTTEMYNEIINYFKQVTGNEPWSLQRLWLRRLGERENFSLSAPTGMGKTTTLITYSTYLSKGVLYIVPTKSLQEQICSKIGAISSVSCGKVDPNTISVLTVSYVNKNYDHMKDYRPNFIAVDDADAIIKSGKTTDKLVELMGIPKDVYEDAMRLVRLRRMLYLKDNKDEIVEKIALLERKIQSFTGIIAQLVVASATLRPKGVKQKALRHISGFDISTAQTYARNIVDSFTFSSLEEVVQKLGPGGLILVSREYGKEKMKEIKESLTSLNFRVELAVSGRKFLQDFSDGKTDILVGSASYYGVAVRGIDEPKRLKYVLFYGVPKSRTRAEESVKNPFTLLRVSRLLGIQVPEEEILGLSPAEAQAIKIAMITGQSLEGRLGALLEKMKVLVEEAQEALRKVDGTITGETFQISRKGREVFIEYPDIITYLQGSGRSSRLLNGGLTQGLSVILVDDQVIFELFKRKMNFLIPGFAPVNFEALELDRVKEEIERTRREGGNKVEIKTGLLVVESPTKAKTISRLFGFPARRSVGGVPVYETVIVEGNRVYILDVMATKGHVTDLTLEEKGYYGVEIKGDKISPLYSHIYRCASCKRSVSKEVETCPYCGSNLISSSLSTINAMRKLALEVDQIFIATDPDTEGEKIAYDVAVNVSPYNPNIMRIRYHEVTRSGIVEALRSGSTLDMNTVNSQIVRRIEDRWIGFELSKLLKLRFGDRNHGAGRVQTPVLGWIVKRTTEYKQRMGWILNVKVGNYVYREFHREKPNIPDSTVEVEVLEEREETLLPPPPFSTDDLLIDAYRWYRIPAERVMRLAQDLFESGLITYHRTDSHHVSGKGMEIAKEYLEKVNLSQEYQPRGWGNEGTHEAIRPTRPLDVDSLKREIAENPTMLSVKFTWAHFALYDMIFRRFMASQMRESKGTIRKYRMKLGESIWEVELLVRMSGGFSNLYTYRLYDVPVGKVNAEINVVRGSDVKLLTYADVIKDMKEKRIGRPSTYAKTIQSLLRHGYVIESKRKAVLVATKKGINAYEFLSKFPDLTSEEVTADLLSKMDAISSGSLEPTTVLLPVLRELQGLETLPKSEQEI
(1035) Reverse gyrase [Metallosphaera sedula DSM 5348]
6
MNADERLPDVVYMGSCPNCGSDITSVRLGKGSVCERCLGEEIDIGSLQQLVEILQNAGTIKSLLREKNILEEERKVIDLFKRVIGSEPLGPQRSWIIRALRGESFPIIAPPGLGKTTFGIVMSLYYASRSEKSLMIFPTRTLVSQVVQKIQEMGKSLDFTPRLVYYVSGLTQSKKDELSKSLAEEDFDIFISTSRYVIQHLDEINKINYKYLFVDDVDAVLKSGKSSLTILKLMGFSDENVTKVRELLKTSRDNTSSFDEIRKIRERFAKDRVAIFSSATITRSNPVFTSLMGFKPGGATIYLRNVIDSYIIGTDIVSQTVELVKRLGPGGLVFVPVDKGLNFAREISQKIDFLKASVVSSNTTKKLEEFEQGSIDVLIGVATHYGLLVRGIDIPWRVRYAIFAGIPKFRFKLGETMHPLAMLRILTLLSVVLKDPEITRILRFVKYRLRRTSTAALAMLAKAVKDGALEDRTMIRAYEIVNTYLKDKRIVEAISKFGDISFSGDYISIPDYLTYIQASGRTSRLYGGHLTTGLSVLLVDDMILFDLLKKKLSFILDDMKWNPLDLDSQKIGDRDLQEIVKQIDKERAEIIRRRKIEPISMPMEKIKTVLLIVESPNKAKTISNFFSRPSIRDFDGLRVYETVIGDKILMVTSSGGHVYDLTTKDLGVYGVEVKSNGDVNVIPFYNTLKRCENGHQFTEYAEGGKCPICMSTNVRDKRSAINVLRRLVLEADEVLIGTDPDVEGEKIAWDLYLNLKPFNSNIFRAEFHEVTRRAITEALNSPRTFSINMLRSQLVRRIEDRWIGFKLSNKLKEEFWKEYCTKTLGNKDCDTENRNLSAGRVQTPVLGWVISRYEEYLRTKRTMYVAKAGNLNILIPKQQGIRKNSKIKIVIQSAERKQDTLGPFPAYTTDTYLSDASGFFFISAQEAMRIAQDLFENGLITYHRTDSTRISNVGIGIAESYLKDLLGERYREIFVPRSWGEGGAHEAIRPTRPLNGEQLRAMVEQGEIEPSKRLTYNHYRLYDMIFRRFLSSQLVPLVVEKEILQISAKKGDETLKLESDTLEIVTNVRLSKDVPIPSEILYIPFRSIGETLLTQIKDKLPAEIDAVITSSFQKSDHALYTQGELVSLMKQRKIGRPSTYAFIISTLLKRGYVFETMKVKRLIPSKLGQHVYEFLNSRYSNFVSEDRTRSLLERMDLIEEGKEDYRQVLKQLYNEIQDIR
(575) Reverse gyrase [Metallosphaera cuprina Ar-4]
6
MNVSDDIPNIVYIQSCPNCGSNITSLRLVQGLTCENCLADGKIKINELSELISILEEQNKIRLLQNEKNILNEEKNVVQLFRKVVGTGPIGPQRSWIIRALRGESFAIVAPPGLGKTTFGIIMSLYFASKSQKSLMMFPTKTLVSQVVQKIQEMSKLLDQPPRVLYYSSGITRSKKAEFNKSLNERDFDVLISTSRYVMENLDELNKIKYRYLFIDDVDAVLKSSKSSITILKLMGFNDDNIGKARELLRLSRDDKSSFEEIRKIRKKFMGERITIFSSATITKSNPVFTSLVGFKPGSATIYLRNVIDSFVVEENPVIQVNQIVNKLGPGGLIFVPIDRGLKYAHEIEKGIEGLNVSVLSSNSTKKLEEFENGSLDILIGVATHYGLLVRGIDIPWRVRYTLFAGIPKFRFKLGETMHPLAMLRILTILSVILKDPNVTNTLKIVKYKLRKISTAALAMLAKSVKEGDLEDRNLIKAYEIVNYYLKQKNVIEQISRFGDVSVNGDYISMPDYLTYIQASGRASRLYGGHLTTGLSVLLVDDTTLFELLKKRLSFILENLSWSPFDIENETVGGIGLKDIIKKIDSERSEIMRKREMGTISQSLGRIKSVLLIVESPNKAKTISNFFSRPSIREFEGLRVYETVMGDKILMITASEGHVYDLTTKEIGIYGVEVHSGDDSHIDAIPFYNTIKKCENGHQFTEYGEGCICPICGSKNIRDKQRSISALRELAMEVDEVLIGSDPDVEGEKIAWDLYLNLRPFNNRIYRAEFHEITRRAITESINSPRNFSVPMLRSQLVRRIEDRWIGFKLTSKLKEEFWRKYCTEFTSRNDCEAGNRNLSAGRVQTPVLGWIKNRYEEYKSTKKKVYVARFNGFSVLVPVQPGIRKNTKVKIIIEDLQRKQETIGPFPAYTTDTYLADASTFYLIPTQESMRVAQDLFESGLITYHRTDSTRISNVGINVAETFLKDMIGEKYKEIFVPRSWGEGGAHEAIRPTRPLNAEQLRVMIEQGEIEPSKRLTFNHYRLYDMIFRRFLSSQLVPLVVEKEVVKISCKKGETTLSLDSNVVEQVVKVSLQKDVGLPSDNLYIPFRSVSTSLDKVVRGTLPFELEATLTNSFIKSNSLLFTQGELVSEMKNKGIGRPSTYSSIISTLLRRGYVFESMKSKRLIPTRLGEEVYKFLSYKYGKFVSEDRTKDLLKRMDDIEEGKGDYRQVLKELYNEIKGIR
(695) Reverse gyrase [Metallosphaera cuprina Ar-4]
6
MITSVFHSSCPNCQGPLEDYRALAGLPCTNCLAGDEEPFRDLPQSEKIKAVYNLLVNNNKLAKYWELYYTAEMYDEVINYFNQVVGKEPWSLQKLWLKRLGERENFSLSAPTGMGKTTTLVAYSSYLSKGVLYIVPTKSLQEQICSKIGSISSVSCGYVDRDGISVLTVSYVNKKYESIKDYRPTFIAVDDADAIIKSGKTTDKLVELMGIPKDIYEDAMRLVRLRRSLYLKEDKDEILEKITKLERKIQGFTGAIAQLVVASATLRPKGIKQKALRYISGFDLSNTQTYARNIVDSFSCSSIEEVVQRLGPGGLILVSREYGKEKMREIKDKLTSNNFNVELAISGRKFLQNFSEGKTDILIGSASYYGVAVRGIDEPKRLRYVLFYGVPKSRARAEEAIRNPFTLMKIARLFGVNVPEDEILSLSPAEAQAIKISIIKGQVLPGKLGEVQKKLEDKISEVQEFLKSVNGIVRGETFLISRRGKDVFIEYPDVITYLQGSGRSSRLLNGGLTQGLSVILVDDQILFDLLKKKMNFIIQGFNPVQFESLNVDSITKEIERTRREGGNKIDISTGLMIVESPTKAKTISRLFGFPSRRTIGGVNVYETVIVDGNKVYILDVMATKGHMTDITLEDKGYFGVDVKNDVITPLYSHIYRCVSCKRVVSKEIDVCPYCGSSLINSSLSIVNAMRKLAMEVDEVFIATDPDTEGEKIAFDISVSVSPYNPKVRRIKYHEVTRSGIVEALRTGTSIDINTVYSQIVRRVEDRWIGFELSKLLKSKFNEGNHGAGRVQGPVLGWIVNKTREYKERIGWLLYIKVGNYVYREYHKTKPAIPDGPVQVEVVGERVETLQPPPPFSTDDLLIEAYRWFKVPAERVMRIAQDLFESGLITYHRTDSHHVSGKGIEVAKEYLEKMNFTQDLQPRSWGPEGAHEAIRPTRPLDLESLKKEIGENPMLMSVKFTWSHFAIYDMIFRRFMASQMKEAKGVFKRFAMRMKDRSWEADLLTEMEGGFSRLYKYRTYDIPIGEINPEINLSRGSDVKLLTYADVIKEMKEKNIGRPSTYAKTVQSLLRHGYVVESKKRSVLIATKKGINAYAFLSKFEDLISEKVTADLLAKMDSIVTGKAEPTSILLTVFDNLRSLEALPQSEQEI
(344) DNA topoisomerase [Metallosphaera cuprina Ar-4]
7
MRLIIAEKPSVARDIAKALGKPVRKEGYLVVGENLVTWTYGHLLQIGDLAPRKWDLKDLPFFPERFWYKAIPGKERQLKVVGTLLSKASEVVNCGDAGREGELIVREVLDYLGFKGRVLRFWTSEALTPEVVRREFMRLRDSSEFDDLYFSALARQNGDWIVGINLTRLVTLKAGGGEVWSVGRVQTPTLAMIVRRDEEIESFKPETYYVILGKFEGIEGVMLRDGVEARLGKDEAERTVSKLEKESFARVLKVDKEERSERPPLLHSLTSLQREANVLYGFTAKRTLDLAQRLYEEFKLISYPRTEARYLGDNNKGLAKEVLKRLGREELIPRVDRVGKRVFDSSRLTDHHAIIPLDKAKDDLPRQERMIYDLVLRKFLGAFMEDYEYEVQRLYLQLDGEIFLSQGKRNVRLGWMELYPHEDNPIPLPSGSVRKDEVRVEARQTKAPPRYTESTLLREMERLRLGTPATRAGIIETLIERDYVRREGKTLRSTGKGRELVKKLASSKVTSPDMTSEWEKELEEIYVKRRGREGYDEFIGKIKEFTREEVVKLLKEEFKVENRATPEMLSLAKMVSKDLGVEVPGTGMEEVKRFLDEYLPKRRITCKCGGEVRAFERGWKCVKCKSVVWREIAGKRITFKQAKALFEGKELKMRGFKSRSGKRFSAVVYLEDGKVKFKF
(372) Reverse gyrase [Pyrobaculum islandicum DSM 4184]
6
MDVPHVVYLHSCPNCGGPITSDRLAAGLPCYECLPKEPQAKAIGEVVEALRRRKALKELARVAEYLREYNKFSAFFKEIIGYEMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFILVATLYMALRGKKTLLIFPTSALAHQAYKKLMSFAEKVGASVKTLAYHSLLTEKEKDEVLAAIERGEFDVLIITSAFLPRRFDLLSRYKFEFIAADDVDSILRATSKNIDRILKLLGVSDEVLKTALDIISLTKQIRKAEVVGDLKEVERLEQELSSARAKLQEEVRKLKLGIFIASGALAKARRTTRLLLFRELLGFDVGGRAEGLRNVTDVYIDMSQDVVMQTIEILKRLGPGGIVYVQDRELGIAIAEKAKERGLSVEHFFKPRRGILESFEKGEIYALVGLASPRSPLVRGIDLPHVIRYVVFVGVPKYRFRVRLEEFSIPAYLTFLYNVRTVLTGELRYKADRLIGQLKRLAPYAISVQEALRKASEGAELTGFDRHVVDVVKSAVDFVNNLLMRDDLRQAIESSTEVKLTRIDDEFYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDKKVFHALKRELKLRFDEAEFKHIDEVDLNAVLAEIDKDRKAIRDILEGRVTPATKGVELLKTVLMIVESPTKARTIANFFGRPSLIVTDGVPIYEVSTGDAVLMITASLGHIYELPTSLKRIDSRQREILAKWFGEFKYDSYNGEEYAVIVKEGSFIPVYNKIWRCRNAVYIDDTDVPPDCKPLDVLSAIRNIAIEVDTVLIGTDPDSEGEKIAFDLYLGLRPYVSDIKRVEFHEVTRRAILNALANPRDINYSLVKAQIVRRVEDRWLGFGLSKILQTKFGNPNLSAGRVQSPVLGWIVKTYEESLKNRVYNVDLQLDAAYCVEPSSCVLRLQIPGDILQTLKKKKRVAIKKESEEERVVNPLPPYTTDELLRDAVNRLGLSADYAMKVAQDLFESGLITYHRTDSTRVSAAGIAIAKEYITKRFGEGVFKPRSWGEATEGAHEAIRPTRPLDVEELRGLVNAGVIQLAIQLRREHYQLYDWIFRRFMASQMEPSVVKAIKYVIEIDGHSLELERVVETIRPGFQQLYPLTPVEPELPTGTIEVAIKRYRVVRKVLSQADILALMRQRGIGRPSTYARILQVLAKRYYVYVVGRRKLMVPTKRGIEVYHFLENNFSNLVSEERTRLIEQYMDAIEVGNAEYEGVLKELFDEFTREILSRAPLT
(1250) DNA topoisomerase [Pyrobaculum islandicum DSM 4184]
3
MILIVAEKRSVAQAIARYLGGTYKVEKIYGVSAYRFLYGNREAVALGLSGHIMDYDFTARQNVWSWLPPEELFKTSPILVLREEAIKYVRALRSLARKAEEVYLALDADSEGEAISYEVALVVRLVNKNVKIYRVRFNAVTYKDIKIAFQNPTKLDLKQVEKVFSRMQIDLTLGAVFTRFLTLTVRDLLEKGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKAVVEIRGYKIEMSADVRFKTRKEAEAVATTIKRGVVKAAIYRPHYIQPPEPLETVELERRASRWLGINSKKTLDIAEELYRAGYISYPRTETTIYPPTLNLREILQELIRGEHSRYVEELLLRGFRPTRGDSDDGAHPPIYPTKGATKSEIYKTFGKIGDNAWAIYDFVVRHFLATLSPPAQVEKQKIVVDFGKIQLEVEGQRTIDEGYWRIYPWERQSDRPLPRVYVGDEVHAIKVEVVERETEPPPPMSESELLALMKKYGIGTDATMQDHIYTNIKRGYMKLQKGKCIPTKLGETLAITLFQYTPELIEPTVRARIERAIQGIVKNGISPNRLIQEIKSEFEKYYNDLKKHRDEIRRALETVLNSKARERSGTY
(509) DNA topoisomerase type IA central domain protein [Pyrobaculum neutrophilum V24Sta]
3
MDLIVAEKRSVAQAIARYLGGSYKSGRLYGVPFYSFTYLGREAAALGLSGHIMDYDFTARENVWTWIPPEELFRATPVLVFRPETANYVKALRSLAKKAERVYLALDADVEGEAIAYEAALVVKLVNRRAEIYRVRFNAVTYRDVRSAFQKPTKLDLRQVEKVFTRMQIDLTLGAVFTRFLTLTVRNSLERGRFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKALVEIGGHAVEMASTERFKTRREAETAAASVKRGVVKTAVYRQHAVQPPEPLETVELERRASRWLGISSKKALDTAEELYRAGYISYPRTETTIYPSTLDLREVLKELAGGEHGPYAEELLKRGFKPTRGDSDDGAHPPIYPTRGATQGEIYKVFGKLGRQAWAIYDLVVRHFLATLSPPALVEKQRIVATFGGVELEAEGQRTIEEGYWRIYPWERQRDKPLPRVEAGEAAKAIRVEVVERETEPPPQMSESELLALMKKYGIGTDATMQDHIHTNVKRGYMRLQRGKCIPTKLGEALATALFQYAPELIEPTVRAKMEKALQDVVRGAAAPTRLIQEIKDEFERYYKALKERRQDLKTTLETALKSMSEDGSGGG
(1187) Reverse gyrase [Pyrobaculum neutrophilum V24Sta]
6
MDLPYVVYLHSCPNCGGPITSDRLAAGLPCRECMPKEPRAASLREVVEALRRRRALRELSWVADYLREYSDFSSFFARVVGYEMWGAQRLWARRLVRGKSFAVVAPTGSGKTTFVLVSALYMAGRGRRALLIFPTSALAHQAHRKLLGFAERAGLNVRVVAYHSLLGEKEREEALAAVERGDFDVLVVTSAFLPRRFDLLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDEVLKTALDAINLAKQLRKAEVAGDLKEAERLERELASLRAKLQEAVRGLKLGVFIASGALAKARRTTRLLLFREILGFDVGGRAEGLRNVVDLYVEAAHDVVQQTIDLLRRLGPGGIVYVQDRELGMAVAAKAREEGLAVEHFFRPRRGVLERFESGEVAALVGLGSSRSALVRGIDLPHVIRYVVFVGVPKFRFRVRLEEFSIPAYLTFLYNVRSVLAGEARYRADRLIGQLRRLAPYALSVQEALKKAAEGAELTGFDRHAVDVVKSAVEFVNGLLAREDIRRAIETSTEVKLAYIDGELYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVVDDQKVFQALRRELKLRFDEAEFKHINEVDLGAVLEEVDKDRRAIRDIMEGRVSPAARGVDLLKTVLMIVESPTKARTIANFFGRPSLIIADGVPIYEVSTGDAVLMVTASLGHIYELPTSLKRVDPAQRAVLAKWFGDLKHDGYDAEEYAVIVKEEGFIPVYNKIWRCRGAVYVDDADVPADCRPLDVLSAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVSDIRRVEFHEVTRKAVLNALANPRGVSYPLVKSQIVRRVEDRWLGFGLSKLLQAKFSNQNLSAGRVQTPVLGWVVETYEESLRNRVYNVDLQLDDVDLRLQIPGDVLQVLRKKKRVAIRKTGEEERAVNPPPPYTTDEMLRDAVNKLGFSADYAMRIAQELFESGLITYHRTDSTRVSTAGIAIAREYVAKRFGEAAFRPRPWGEAAEGAHEAIRPTRPIDVEELRGLVNAGVLQLAVQMTRSHYLLYDLIFRRFIASQMEPSVVKVAKYAVEIDGHVLEIERAVDIVSQGFQQLYPVTAVEPELPTGTLDVAVKRYRVVRRILSQADVLALMRQRGIGRPSTYARILQVLAKRYYVYVAGRRKLMIPTKRGAEIYHFLRENFGSLVSEERTRLIEQHMDAIEVGKARYEEVLKELFDEFRRDVLPRLAYFST
(1045) DNA topoisomerase [Pyrobaculum arsenaticum DSM 13514]
3
MILIVAEKRSVAHAIAKFLGGRYKLEKIQGVAAYRFNYGGREAVALGLSGHLMDFDFTARQNVWTWIPPEELFASQPLIVYRPETMKYIRALRTLAARAHEVYLALDADVEGEAIAYEAALLVRLVNPRAKIYRVRFNAVTQREITNAFRNPTHINLRMVEKVFTRMQVDLTLGAVFTRFITLAVRHSLDRGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVVKALVEIGGHRIEMSADVRFKTRKEAEEAAATINRGVVKAAVYRPHHVNPPVPLETVELERRASRWLGINSKRTLDIAEELYRAGYISYPRTETTIYPPTLDLREVLQELASGHLGSYADELMRRGFRPTRGDSDDRAHPPIYPTRAATKGEVAKAFGKLAPQAWAIYDFVVRHFLATLSPPAVVEKQKIIVSFGKLEMEAEGQLVVDEGYWRIYPWERQSSKPLPRVSPGDPARAVKVDVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIHTNVRRGYMKITKGKCIPTDLGIALATSLFQFAPQLIEPTVRAKIEKALNSIVTDGTPPARLIYEIKKEFEEYYKALKARKEEIKKALETALNSSRNSQRG
(992) Reverse gyrase [Pyrobaculum arsenaticum DSM 13514]
6
MVPLVVYLHTCPNCGGPITSDRLVLGLPCRECLPEGTKAGSIREVVAALRRRRVLKGLAWVDAYLRGYEGFTEFFKKVVGFDMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFVLVAALHVAKEGKKALLIFPTSALAHQAYRKLLVFAERAGVSVRALAYHSLLSDREKKEVLDAVQRGEFDVLVVTSAFLPKYFDMLKAFKFDFVAADDVDSILRATSKNIDRILRLLGVSDSVLSTALEVINMTKQLRKAEVAGDLKEMERLSQQIAELRAKLHEEARRLRLGIFIASGALAKARRTLRLMLFREILGFDVGGRAEGLRNVVDLYTEASGDVVEQAVELLKRLGPGGIVYVQDRELGMAILERAKAEGLAVEHFFRPRRGVLESFEKGELVALVGLASSRSALVRGIDLPHVIRYVVFVGVPKFRFRVRLEEFSIPAYLTFLYNVRAVLASDLRYKADRLIGQLKRLAPYALSVQEALKKAAEGAELNGFDKHAVEVVKSAVEFVNSLLEREEIRKAIETSTEIRLTYVGGELYVLVPDVTTYIQGSGRTSRLYVGGLSKGLSVMIVDDAKVFQALRRELKLRFDEAEFAHIKEVDLDKVLQEIDRDRRIIRDIIEGRVAPERRSVELMKTVLMVVESPTKARTIANFFGRPSLLVAEGVPIYEVSTGDTVLMITASLGHLYELPTSLDRIEARQREMLLKWFGDFKTDGYDGGQYAVLVKEGAYIPVYNKIWRCRGGVYVDDVDVPPECKPLDVLEAIRNVAVEVDTVLIGTDPDSEGEKIAFDLYVSLRPYVQDIKRVEFHEVTRRAIINALANPREINFSLVKAQIVRRVEDRWIGFGLSKILQNKFQNPNLSAGRVQTPVLGWVVKTYEESLRNRMYNVDLQLEEGELRIQISREALDVLRKKKRVAIKLAGREVRSLNPPPPYTTDELLRDAVARLGLSADAAMRIAQDLFESGLITYHRTDSTRVSAAGVAIAREYITKRFGEDLFKPRTWGEEREGAHEAIRPTRPIDVEELRGLVNAGVIQLAIRPTRAHYQLYDLIFRRFMASQMGPSTVEVAKYQLEIDGYVVDIERVVGIKEMGFQTLYQVSRVEPELSTGTIDVVIKRYRVVRRILSQAEVLALMRQRGIGRPSTYARILQILSKRYYVYVTGRAKLMVPTKRGIEIYHYLEEAFGPLVDEERTRLIERHMDMIEEGKAKYDDVLNELFTEFRKEILPHLSA
(1708) DNA topoisomerase [Ignicoccus hospitalis KIN4/I]
3
MKGHILVIAEKPKAAEKIANALGKPIVKRKYGVPYWELTNGKKIVVVPAAGHLFGLAPLGKGFPVFDYEWRPLYEIEKGASHTKKYIALISSLSPGSSLYVNACDYDVEGSVIGYIIIERFGDPRRSKRMVFHALTPDEIRRAWNSLRPLDWEMINAGLARHELDWIWGINVSRALMHAYRVATGKSKSLSAGRVQSPTLKEVVERELAVQCFVPEPYFSVSLSAKGVSLEPTLKFETKDEADHFISNCLGKVVDVIVNDERLSPPHPFNLPDLQMEAARLYGFSPSKTQSIAEELYLDAYISYPRTNSQKYPKDLDYANILKGIASVPQYRPLTKALFKETRGRFSPNNGPKDDPAHPAIYPTGKPPKNLSPDHMKVYDLIVRRFMATLASESVYEVTKVVIEVNGQTFKAVGRRVKWKGWTLYYPFSAPQEKSLPSFTKGESLQVKCTRRLQYTKPPERYTKAKIVKWMERVGIGTEATRARIVETLFKRGYLKNVGSKVYATDLGIGVALVLSKFFPEIVSVELTRRFEEDMKKIMMGVERKEKIVEEAKKFMRMILAKYKPHMREVGEYLAYSLGEMEPPGRCAVCWRVAEEDGLCVVHKRARDELYAKYPVWRRRLGLSFEEYLKKVTTLKQAGTAAKEVAKALLSEPTFKG
(1264) Reverse gyrase [Ignicoccus hospitalis KIN4/I]
6
MYASYRRSCPSCGGEIEDVNLSLGLPCDKCLRVVGLESLKLDPSKKDSPSVRRRLIELGGPLGESLKLEEELESLEKVFQEVLGAPMWSAQRAWALRALRGESFSIVAPTGMGKSTLGALLSVYLSHKKKKKSYIIVPTTPLVDMMFRKVSAFAEAFGVRAVYFHSKMSPSQRKEMKERLLSGDFDVLITTSRFLINNLDLLKNYEFGFVFVDDVDSVLKSPKNVDRILMVLGLQESDVKRLEEVDKELSRKAQVLTKLQDLQKRYQLLKEMRELEEELEDLKRKVKGNLIVSSATGRAKGNRVRLFTRLLGFTPGGVGEGVRNVVDSYSRSSDVVEVVKKLGKGGLVFVPADLGAKGAEEVAEALRAAGVAAEVATSERIGVIKDFEEGRVEVLVGVATHYGVLVRGIDLPHVVRYAVFVGVPRFKFKLKLEEPSPMTIYRLCSLAARFFEECASLYAKLRKWVQRLGPAGLQSVEEALKEGSASTPASKDFMEAYTKLKEIIEKTDFIEKLKESGEVDVVAEDSLYVLIPDAATYLQASGRTSRLYAGGVTKGLSVVLVDSEPLFRGLKKRLAWVVEEWKEFESLNLSELLKEIDEDRKKVLKVIRGELKVEEVRDLMKTVLMIVESPNKARTITSFFGRPSVRQVKGVKVYEVTLGDKLLYVAASGGHVYDLVEEADPCNEEPCMLFGIRVKDVPEEVLSSIKRCAVCGHQFSGDVKECPRCGSPFIKDAKDVVDGLRELAQEVDEVLIGTDPDTEGEKIGWDLKNLISPFAKKIRRAEFHEITKKAILKALENPRDFDMGYVWSQMVRRAEDRLTGFTLSPKLWFELWPQLCEVSKEMKKKLLGCPLTRNLSAGRVQTPVLGWVIQRYEEYAKSKKKFYIIRFDGRELEFSEDELRGFSKKLAIDGKVKILKVEEEVEELKPLPPYTTDTMLEDASKLGLDPSRAMRVAQDLFEMGFITYHRTDSTRVSDAGIAVAREWITSKFEGLFAPRRWGEGGAHEAIRPTRPLSAEDLKRLIEEGMITPPRELSKQHFMLYDMIFRRFMASQMKEAKVKKAVYEITVEEGGAVVGKKVLEKYVERVFDGFLLVYPIVKIESLPEGEYEVKEVRAVSRHTVPLYTQADLIRLMKERGLGRPSTYAKIVSTLLERRYVTLSKVGKKLVPTVRGYAVYSYLTGKVVGAGWVRKALEVIINPEGKSKYFQKLVEEEATRRLEKVMDEIAEKKDEKMYINVLKDIIEETKVIPFLSDKGAQPSLR
(1683) Reverse gyrase [Ignicoccus hospitalis KIN4/I]
6
MIEAVYQRSCPSCGGDVERERLLAGLPCSKCSEPRGLLAWKEVLEEEYEAFANFFKKAYGFELWGPQRAWAKLALSGSDAVLLAPTGTGKSTFLAALSSFLKRKGKRVLYVVPSKSLEEQVKERLAEEVDVITMRRLVRDPRAYRGYDVYIFDDVDSVMKSPKSATALIIALGLEEAVPIVNEMVDIIKKGLSDEGRRGRYEELKGELERLKDKKGSQVIMASATAGGGSLTAKLILSLLGLSPASAPPAIRYVDDVKMFHEDPVEGAAEVVRYFTSEGLKGIVFVHEGFPIEEVERALRERGVAAEVVKSGKLKALKKLEKGELDAVVAYSSRYGVAARGIDMPDVIRFAVFVRPPFKKFDLERGLNNPLTLLRVMKKLEMKEDTVKLFKMLSKLSEVELALLRRAMEEGGELEGFLGDALSALKEMKGKVLERLKGEKVVDKGFVVKDGKVFLLDPKTYLQASGRTSRLTPKGMTHGVSVVVYDDEDLMKAFEESLKDRVEFKEELVTPKGPKPVKAKNVLIVVESPTKAKTFARIMGGGGKVEVGGVAAHLAVHEFGGEALFAFIVATKGHLFDVTLDEVGTYGVELGEPVRVYYAPINRCRRCNLAWASSDPRCPKCGLPAESSSKVVEALRRLATVVDEVYLATDPDEEGEKIAWDVMAMIYPFNSNIKRMKYYEVTLRGLHEALSFLTTVDEGTVRSQIVRRLDDRLVGFAVSERLKAAFGDPNHGLGRVQGPVLKFVVERAKARKASAGYSVTLHLSNGDTLRLFVKTKEEALKLASVEEVKILKVEEEVEELKPLPPYTTDTMLEDASKLGLDPSRAMRVAQDLFEMGFITYHRTDSTRVSDAGIAVAREWITSKFEGLFAPRRWGEGGAHEAIRPTRPLSAEDLKLDFALNGMSFEALRLYDMIFRRFMASQMKEAKVRKVKVVYEVAGKRVESAWVAEILEPGWTSVWNIKTKDIKLEKVAKVVSSEVRRASLVQLPKVFEVIRWMKERGVGRPSTYAKTVENLRRHGYVVITPNNYVVSTKKGVAVAEYVERNFPELAEAEYTRRLEEAMELAKSDFWGAFNNTLRAFRALASLES
(597) Reverse gyrase [Ignisphaera aggregans DSM 17230]
6
MSGINIVFDLGGKGDEELLKIPRGIYLGLCINCGGPIEDNRIIYRNACSKCMNSKDLVEVRDLEELAKHVTSLNPNGRLNYILTLNKFVKEFEEFFQKSIGSKPWSLEISWALRVAQHQSFAMIAPTGVGKTTFGLVMTLFLSYKYGKKVYIIVPTTVLVEEYEKRLWQFSEKLGITLKIIAASSKIHGKRKIELEESIASGSFDILITTSAFLQRNFNDVFKKMLSNNIKMDLIFVDDVDAIIKGSKAIDMVLQLLGFSEEDISNGYKMIDLRRRLLQCENARESSRCYIDGKPIDVIYEELQKKVLEKRERCGILIVASATGRARGKRIKLFRELLGFSIGTAIEVNRNVVDAYIPIDNPAEIIDRLVSIIKILGSGGLIYVPLDLGQEYAVKLATELNSRGIRAGVVISGKSEDLKKFIENELDVVVGVATYYGLLVRGIDIPERIRYAIFVGVPRHKISLTRIEYYPQTLLRLLSVLVDVVEDQMKDRVLRNIAYLRRILRRISPNRIFDIVERLKKGEKVEDELAGIITNAYKLVNELLSDSKIIDRLKKHERVSIIEEEGQLYILIPDAPTYIQASGRTSRLFMGGITRGLSIIFVDDTRLLRGLEERIRVYIDDFRFQSFNEINLEEILKQIDEDRRIVNLIKRGLLEEVIHIPKFSFSRSILFIVESPNKARTIASFFGRPTIREIDGLRVYEVDIGNAHLLIASSGGHVFDIVEEELSENNIYGVQRTVENGKQLFLPIYGYLKRCSVCGAQFVKGTVCPICGSTRIRSSEKIINALQKIALEVDEVIIATDPDSEGEKIGYDMAIALAPYAKIIRRAEFHEVTRKAILSSLYNPRGLKLSLIEAQIVRRIEDRWLGFALSDYVTKRFKELKLESREGRLSAGRVQTPVLGRVIEIYINRLRTQRKYKIFSIGNISLEIPVEDLKKIFGDELKRISKERVEIVLKLLSHEIVNLNPMPPFTTDELIVEAQRQLGIDAVETMRIAQDLFELGFITYHRTDSTRISSTGISIAHEYLLNKFGDLGKELFVPRTWGEGGAHEAIRPTRAMDVDMIQEIIAEQLIELPIRLTNRHLRIYDIIFRRFIASQMKSAKVERNRFEAILKIDGIEVAKQHIEIISNIVEPGYTLIYMPFKTVFLPHGSIALKPLHIKTAILSDVKLPTQGDLVKWMKDVGIGRPSTYAKIVEILLRRGYTFRHRKGSVLIPSITGIIIYNILAGTMLPSIEVDEEEFINILQKHPSIRKYNPEALRQTLAEILRNLSIGIRNMVSVERTRMLYNKMQEIEEGRLSYINVLSELFREMCSNVINMISSEAIEICKS
(1762) DNA topoisomerase [Ignisphaera aggregans DSM 17230]
3
MNIKDYILVIAEKPKSAEKIAYALGNPKKYRINGVPVWFVMRGTSRFVIAPAAGHLYTLHTESKGFPVFDYKWVPKYIVEPESIFTRKYLNVLSMLAKNAKEYINACDYDIEGSLIGYMIIKNIGDIKRSKRAKFSSLTASEIVRAFNNLLPLDYNMIEAGYCRHILDWLWGINVSRMLMSIYRSVFNEKRILSAGRVQSPTLSYVVNIDLQRKTHVPVPYAYPSIKIFIDNKIFKLIPIDSPFNSLSDAKEYLENIKRDPRATVLDIIVRDERIEPPHPFNLPDLQSEAHRIYGFTPYKTQKLAEDLYLEALISYPRTNSQKLPPTLNNREILEKLSQNIVYRTLVKTLLAETRGILRPNNGPKEDPAHPAIYPTGEGTLKGLSKDHIKLYDLIVRRYLATFANPAVVQYVRIEFIVHGRRYYLSTNIVRSRGWLQYYPYIHFNGEEISLKLLRKGLQIPIHEAKIVIHFTKPPHLPSKISLVKWMEEKGIGTEATRAEIVETLFKRGYLYMRGRGSGVSELGILISFLLKDYVEELISVELTRKFEERLNMILNMKAKCDDIVEEAKEMLLKYINRVKSLDIQTLRAEISKYIEMSDNNGRRCMICKRSVYANNLCIFHNIALENIRSAYETWRKFGFSWTQYLEKLLKLKSTGSYVKEVCRHLIKQGEF
(919) Reverse gyrase [Ignisphaera aggregans DSM 17230]
6
MTLAIYRHGCPYCGSSIYVGEDSWSCENCEMINRFRHGNSYVDVWFKEIRDFIEFFRMATGFSPWSLQTYWIKRLLSGESFAMVAPTGIGKSTLLGVYALYRAYFYRSKIYIITPTREIAKQFYSKISEYLRTISKNFHGADKLRIIFYDSSSKNHKDILKLINENMFDILITSSSFLSRHHVIVDSSKIDIVIADDLDSIMRNSKSVDRVLKILGFDEKIVNLAMELVKLKQSFYVAKLAKSQESVENIRRKIIEMEAILKNEVAKRNTQLVVASATGRSAGMKALILKELLGFDSGAIFEYWRNIVDIYSQIDDKMMIYIKEIIEKMKSGIIFVSSPYKDYIDVIVKKLMDMNIKVAVVKSGNKAVDKFRRGEVDVLIGSSSYYGILVRGLDEPQRIKFVIFIGLPQIMKELWNSLSNIRLLYMIAKCLNEQGIDLSNDIKTLINIIQSSSPAQLILLSKALNGREYPNDLRDKVEELAKIRDRVYEEAKKFLDTNGKLVINNYGILVKLGHRYVILKPDPYTYIQASGRCSRLFNGIKTFGVSIVFENYKELIELMEKKMKRFVDGFRFINLSDADIDEYVLRAESTRSLNFSGDGTIDIRKGISTALIIVESPTKAKTIASMFGKPAKKVYGNVIVYESIIPISRDKVYVSMIVATLGHITDLVTDEGLYGVRVNNDRYIPIYDFITKCRRCGAQIVGIYDECPYCNSIDVQSSNTIYNVLKKLALEVDNIFIATDPDTEGEKIAFDIYNLLYPINKNLFRIEFREITKNAVLEALKNPRRIDIKRVKAQMTRRIIDRWIGFELSMVLQDKFNKPWLGAGRVQSPVLLWVARRYKEYIDSIGYILYCDLYGYKIKIYLGNNVDRNYVEKIMDRISNEGLEVKDVEIIERTIQPPPPFTTDSLLYEASNKYGYSASKIMAIAQSLFEQGLITYHRTDSTRISSLGLSIAREALAKENLLEYYVPRQWNVENNAEDAHEAIRPTNPINADELIELIMRGELGIITRISDDHLKIYDLIYRRFLASQMKPARVLVLRANIGIDKYFTNIEAIIDIIEKGFMSIYPLKIYPDLRNLEKTTFIKPNKIFVKKGSAIGLYRVADLIRMLKEKGIGRPSTYAKAIDNNIRHGYIILSKKVKATIPTKLGKEISEIIEQRYINLVGDKVTYELEREIDLIERGLRDMNYVLNRVRQAIDIIINTEGNNIIQLFSDTETVNISDNRVELISSE
(363) DNA topoisomerase [Pyrolobus fumarii 1A]
3
MVAGGCRPPRGYGLIIAEKPKAAAKIAEALGGRYARRCTAYGVPYWVLRVDGRLFVVAPAAGHLYGLYTDERGFPVFTYRWVPLDVAEGAKHARKFLALLATLCRDASIYINACDYDVEGSVIGYMIIRNLGDVRRAYRMKFSALTPTDIRRAFRRLEPLDWPMIEAGLARHELDWLWGINVSRALMEAVKLVTGKKVVLSAGRVQSPTLVEAAKREARRRLHVPYPRFNVQVWLAGREGRLKLTIASREKLIEAKRIADRVAARGYAFVSSVAGRREYVKPPPAFNLSDLQMEAARLYGYSPAFTQEIAEQLYLDGLISYPRTNSQKLPHTLDFRGILEGLASIPAYTQLVKRLLLETRGVLRPVQGPKEDPAHPAIHPTGAVPRRKLNRAEERIYDLIVRRFLAAFSKPAVVERVTATLDFGVVRVNVSGTRVLEEGWYVYYPFSRPKDDIPRVSRGERLRVERVVVETVYTEPPEAYTKAKLVRWMEEVGIGTEATRARIVETLFDRGYLRLSGGYVTVTDLGFAVAEVLEKFFPKLTSVAMTREFERLLEDIRRGIRRRAEVVEEAKRVLSLLLEDYKKRAMRDAGLMLAKSLRLVEAERPCVICGRESVDGRLCRFHLEALEALKRGFVEWRRRLGGIGWEEYLERVASLRETGMWVRDVAKYLLETGLAP
(1020) Reverse gyrase [Pyrolobus fumarii 1A]
6
MAGDGWRLHGVYWYACPHCGGPIGDDRLYHRLPCARCLPDDRLSLLEPNPDGTYDPRRVAELLEPREDSPYLALAELEREVERAEAFFEKAMGSRFWSVQRTWLRRVLRGKSFAAIAPTGIGKTTFGTFTAVYLAATRGVKSYIVVPTTPLVEQVEERARRFAEAIDPGVRIVAIHSRLPRKELKRRMDAYRNCDFDVLITTSSFMLRHVDEIISVLEGKCGQRFYLVFVDDVDSVLKSSKSVDAVLKIVGFSDEDIKAGWELLKLRREIARLSARARSKGEIDPRLAELIEKARELEKRFEGKRRCVCGRCNHRDCVSVLVVSSATGRPRGTRVRLFSVLLGFEAGSRPELYRNIVDTYVKPRDGIEEEVVRLVKRLGDGGLVYVPVDKGASYAERLAQLLSDAGVRAEPFTARNPDALERFRRGETQVLVGVAIYYGVAVRGLDLPERIRYAVFAGVPRHKFSARFEDPHPTNIMRVLGLLAEHAPDDVRSEAEKLLARLRRIVRRLSAAALQKLAEELRSGEVSSDAARLFQEALRFVREALSRSDVWEALEKAPDVAIVREGDKSYIMIPDVATYIQASGRTSRLYAGGITKGLSVIVVDDDRLLEGLRRRLRWYIGEAEIRPLEEVDLDKLLREIDEDRRRVRDVLSGRVKPEYLELVKTALLIVESPNKARTIARFFGRPSVREIAGLRAYEVSTGDYVLTIVASGGHIYDLAKTYYPLDVIPSWWLREFNFEGRVASIDEFVTGFDWSSAENKHGVFVAKRGSVRYLPVYTPLVRCPDCGFQSAANPSLAPNEEQTIRDVIKARLGKDVDPFDEKSLPRYCPRCGSPSVRTSLPVIEALRELASEVDMVMIGTDPDTEGEKIGWDVAALIAPFANKLVRVEFHEVTRKAILEAIRNPRPFNPRLVEAQTVRRVEDRWIGFTLSPILWRDFWLNYYCPRMTERLRKRLEAIRAKIRALRRRGMRVPDELKKRMERIEALLRACEGPNRNLSAGRVQTPVLGWVIDRWSRFSGEQKACAARRGLPSEECPRLQVTVSSDGVRVVFEAPGSLAPRLRPGTLVELVEVGREVVEENPLPPYTTDTMLADAWDKLRLPAPVAMQLAQELFEMGFITYHRTDSTRVSDAGIAVAREYIRQKWGEEGLEKLFRPRRWEPPRLIGVEAAHEAIRPTRPIDADTLRRLIEEGVIETPRPLTKRHLALYDLIFRRFIASQMAPARVELQVLEVRLGGEKLVEVKRRAKIVEEGFLMIYKPWEVEGEAPAGEYRVVSVRGRPETWPLTQAEVVRMMKERKIGRPSTYARIVETLHQRKYVKTLPKTGWLMPMPRGRLVYKYLAEELGSKIPVVRNMISEERTRELLEQMDLVEEGKVDYQVLLDEVYRELLEVEKALKELTGGTPTPPK
(1324) Reverse gyrase [Pyrolobus fumarii 1A]
6
MAKLTLLYEAGCPNCRGRIDEERLIKGLPCWECLPLLPEAERYLSGLDWRERVLAVARLLEEHGKLEGWAWLAREEDELSIFERFFERATGSRPWSVQRQWARRLLRRESFAITAPTGTGKTTLLAVYALYSAVNGSRVYYLLPTSSLAKQVAERLQLLAHNAAVRKRIVYYHSLLRASEKRAQLEAIENGEYDILVTTTAFLSRRWGLLERTMFDTIIVDDVDAILRDSVNVERILMLLGAKPDEIRAATRLVKLSLRVRANPALARRYASEIEELKRVVNGVAGRLGQLVVASATGRARGFKRLVLGKLLGLSVGSIAGYARNIAEYKLLASSPEDAIEKLVETVAKMGPGGLVFVAKPLGVETAKLVVNRLGERGVRAGLAIAGKRVIEKFERGEYDVLVGVASYYGVMVRGLDMPYRVAYALFLEPPFNRTPIEKALQSPRRILALAKALDVEGYREYARILSKMTPDEVELLRAVLQGRLEAGGRLAEAAEKARSLASAILEKLRSVTSEVPAGYSILTVSSSGAYVATPDPYTYIQASGRTSRLIKGYMTRGVVIVVSSAPLLLERFEDRLARLLAGFELREYNEKEVLEELEKAWESRRAPAVSRSALRMNIETSLVIVESPTKARLIAGFWGKPARKEYDGVNVYETVAYNPKSGKTHVMLIVSVKGHVYDLTEEPVGKHGVILEGSDVKPVYAPIVRCRDCGAQHAIVAEQCPECNSVNIEDKRRIIELLRKLAPLVDTVYIATDPDYEGEKIAWDIYTLLKPYAKNIKRIEFHEVTKKAILEALANPRDVNRRLVEAQVVRRVEDRWIGFELSQHLWKVFNARWLGAGRVQTPALGFLVERLEEWKKGRCYALIARLPWGRVKLCYPDSRTAREALREALEKGVEVEILEANIVSLTPPPPYTTETLLYDASRLLGYTAEKTMRLAQELFENGLITYHRTDSTRVSDAGIAIAKSYMQRRGHAKLLMPRHWGEGGAHEAIRPTMPLDADELRDAIAEGEVRIVTRLRESHYKLYSLIFARFMASQSIPARVERVRLRVTVGNVSVEDVVARKVIEAGFLTFYPHVIPVYNVQEGRVKPMGARIVRTSTVRLYTHGELVMEMKRSGIGRPSTYAKIIEALKRHGYVVESRYRKYLVPTSMGRRVYQYLVTEFRPLVSLERTRLVESLMDSVASGEAEACRVLLELLEEVEGMVARVEAGRGAGLGENLAA
(1174) Reverse gyrase [Thermosphaera aggregans DSM 11486]
6
MLTYVLNPLYRSSCPVCGGDLTSRDIEEYGKCSKCRSRLDSSLNVFTLNKIIEDEVEDFEEFFKTATKGLTPWGAQKTWIKRILSGENTVLIAPTGMGKTTLLVAYALFASSRGKKILYITPTRALGKQIHARISGDAGSEHSVFYDSGLSKRRKQTLLEKIGKGDFKILVITNSFLGRNFDLLSKHEFDIIIVDDVDSLLRSEKNILRLLLLLGFNEEVVQLAKKRLQLLWRLMVSKSLNNEESYYSIVKEYLDLDAKIEASLKTLKRRQLIVASATGRIKGLMGRILKDLLQVDVSGITIYGRDVTDSYFLRSLDEASRELAALVKTLGPGCVIYVSPRHPFKQQLVKLSEDLRSILEREGFKIADATPANVLKLVSRQVDVLIGSASYYGSGVRGIDAPQSIKYVVFLGTPVFTVSLDSFLSNPNMLARILIELAEKTGIKSLREKAYTVRRLVYYLSPGETRLLRNVLKGKIPEEAVKPHEKLYSKYVELKTLYSETIREVEKYLDVNTVLEAGSITLLKSRDGYVALIPDAMTYIQASGRVSRLYGGRMTHGLSLILETPLLSNLVKGLEMKLKLINKDLGFRELEELDLSVEKEMAESTRTRSGEWLLKYRSVLIVVESPTKAKTIARFFGKPVSRRIGDVNVYEIPVKIGEEIVDLNITATRGHLYDLTTDPYTDNYGIIVETGLVTPVYETIKRCRVCGTQFTHEASCPRCGSGVFSDQKAIVNALRKLASEVDEVLIATDPDIEGEKIAYDVYLAVLPVNSNVWRIELHEITLQEFLKSIERKRSVDRNKVLAEIYRRSLDRLVGFSLSQDLWSRFGKRYLGAGRVQTPVLGMIIQRYREYVEGRCRKIELSLGSPLNTKYSVCVDNNSSLVDEARRAGKILLRKEGEEVVEIAPKPPYTTDEFLVDAARRGIPVSLAMKIAQELFEAGLITYHRTDSKYVSATGVSIASKYLASKNLRNLFKPSHWGEPGAHEAIRPVYPYDADDLMKAFTEGLIPLTIPLTGLHYSLYDMIFKRFIASQMKPFKAVKARFSLWVNGISLGTMEVYTRIVEEGFNAVAGIKTHEALGSVEEAEVPVKEVKTSISSRTFLYSEGDLVALMKKTGIGRPSTYSKIISSIERHGYIVKSRKKLKLIPTKTGVMVYDYVSTAYPDLTSIELTRRMEDLIDEISMGRLNAAEVIMDLIQSLSTRSLITVKTVNTFSSQL
(625) DNA topoisomerase [Thermosphaera aggregans DSM 11486]
3
MNNIYSTIGRGPGFTSIWDLKGKVLVIAEKPKAARKIAEALSQRYFVRNINDVTYFEIRDGPRQIIVASSVGHLYGLTTQEEGYPVYTYQWVPLYVVEKKKAHSYNYLEALRKLCTTSNYFVNACDYDIEGSVIGYLIIKFNGDPGRAYRAKFSSLTLSELREAFRRLTQLDYEMIEAGLCRHELDWLWGINVSRAIMRTVESFSKKKIILSAGRVQTPTLKYVSDIEKERNLFIPIPVYSVVPTIVKDGVKITLELINSPIRTKKDAYALAERIRREGFLTVESYVEHTTSVAPPPPFNLGDLQEEAARIYGYSPSKTQSIAEQLYLDALISYPRTNSQKLPSGLDFKSLLTKISQISNYSALVSDLLKETKGYLKPVEGDKEDPAHPAIYPTGVRPVKLSSEQWAVYDLIVRRFLAAFAGNAIIYRSTAKFALPGENIVFQATGQGIEDLGWYKYYPFHKPSVKVLPRFRNGERVEVVEVSVKTAYTRPPQRISKIGMLRWMESVEIGTEATRATIIEKLFERKYLVNTSRGVAVTDLGLGIVETLEIFFPELVKVELTRHFEKLMNDIKKGVVKREQVITEARNTLDMLIKKFNEKKETVGQILSSRLGIYTPPNKCAICNREEFSNGLCTYHYKANEQINKVYEEWKEREGVSFKEYLERIKKLKSTGKWVIEVIEHFYGGK
(221) Reverse gyrase [Thermosphaera aggregans DSM 11486]
6
MSNLLNPYGFYRHACPNCGGEISDHRLFYKAPCEKCLSEGDFKKTLKRIRSEGLRDYKSIIEAYYKDLKNPEGLRQLLDEEVALEDFEEFFERATRGNKLWSAQRTWARRVLKKKSFSIIAPTGTGKTVFSLVISLYTVAKSQRGDRRRVYLVFPTLPLLLQAESKVKHFATNAGLKICEDRAEESCIRILVAHGRSDKKSKEELMEQVRNGDFDILLSTSAFFHRNFELLKNKDFALIVMDDVDAVLKSGKAIRKLLNLVNVTDDAINDGLNLIKLRQRIVFSSGEEKEKLSAEIEELEKKIARVKSEIKTTLVVNSATGRPRGIYPKLFKVFLDFEAGSKPEAIRNIVDAYIEADDPENALLEIASKLKDGFLVFVPVDRGVEYADKIAELLKAHGLKSESFHAKKKIDVLNDFARGELNCLVGVATYYGVMVRGIDLPERVKYVIFLGVPRHKFSTALEEISPTDLLRIISVLRDIAPEESKRELESLVGRLSNRLKRISQGALFKLREDFAKRLKGEHVEETVLIKELLRAYELARELLRDEEIWRKLSNLGDVGLLWENGRQYLLIPDVATYIQASGRCSRLYPGGITKGLSVIIVDDKRLLNGLNKRLRWIFEGVSIANLRELELEKLITEIEQERVIVGKILRNEYRPEGQVDLIKSALLIVESPNKAKTIANFFGKPSVRVLGKSLQAYEVTIGDYVLSIVASAGHVYDLVVDLQENYGVRRVGSRFIPVYTDIKKCVNGHQFVDETDKCPRCGTSRVVRKADIVSALKELAREVDLVLIGTDPDSEGEKIGWDLKVLLEPYAREVRRVEFHEVTRRAILEAIRNPRSFDTRLVGAQIVRRVEDRWIGFSLSEIVQKYAWTSYCFENLKDKGHDCCRENRNLSAGRVQTPVLGYIIKRYRDKEDKSLYKYRLLAEKDGEKISFTIDRAQAVNAGLVSILEKNNKRRKKDKNYPPLVIKERELIVEAKNPPPPFSTDALLEEASKSLGLATTRTMEIAQDLFEMGLITYHRTDSTRISEAGLTVARQYLEERYGDKYRDVFQPRTWGEGGAHEAIRPTRPIDADRLAELVREGVIVLTGRLTRQHILVYDLIFRRFIASQMKPAKIGKQVLTVSINGVEAVVERVVEVVEKGYLEVYQDVKLETRITEGEGRITEVVEVKPPMARYHDVIRWMKENGIGRPSTYAKIIQTLLDRRYVDVTKKHKALRPTERGIFIYRFLDEKFKEVVSVETTRRLEKDMSDIEEGRVEHMKILEKLYNELREKILDNPIIKELEDEYSERCGRKSDAA
(1831) Reverse gyrase 2 [Aeropyrum pernix K1]
6
MPGGVNAVYMGLCYNCGGNIDEDRLEKGLPCARCLPSPPRRATPLTVYRALKKAGTLGAYSWEYLSIREVERFEAYFAAKSGSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYVAAVKRGRVLYLVPTENLVRQVYAKLDQVEPGIATAYYSRMPAKARESSLEKIASGGARLIVATTGFLSRRFDLLHPQYKFDLAIVDDVDSLLRNSRNVERILLLTGFSEETVEAAHSLVKARLKLYRALHSGASESIVSRLEQEIAQLEARLRLSLSEASPGQLVIASATGRPRGVKHLLFKELLGFEVGGGSDYLRNIVDAYVVDSDPVGRTAEIVSALGDGVIVFVSQRLGKDVARAIAGRLEGMGVSTALALTGARRPVEAFARGEARVLIGMASRYGVIVRGLDLPERSKYAVFLGAPSAKTHLLEALYSPRRMLAFLSIAQEKGVEWAGEAFRRLSRLLEKVIDTSIVSLAARGKLEAQGPAGEAAGIISETAPRLVDWLVAEARLQGGLLRVGGLVVDARGPIPYLVVPDAPTYIQASGRVSRLYRGVMTRGLSIVVDEAPEYVEALGERLKWTTSSRLRPLSEVDMEKLRREIEESRRGKGRRVRVKTTLLVVESPTKARTIAWFWGRPGKRRIGRSVIYEASVSDPETGDVHILQITSTRGHLTDLTTDSVGSKYGVDEDGGGYRAYYSTIKRCLDCGAQHTSSSPFCPRCGSPRQVDSKSVVEILRKLASEVDEIVIATDPDREGEKIAWDVFLAVRPYNPNVRRGRFHEVTPRAVIEALRSGESVEKSLIEAQKVRRIVDRWIGFHLSTHLKLKFSKPWLGAGRVQTPVLGWIVDRYREWQDTRGYLVIFKLSSGGRTSYFTQNRLEVENLKRVEWLEVVDIAGKTEERNPPPPYTTDEYLYDASRKLGLSAGLAMKIAQDLFESGLITYHRTDSTRVSPTGVKLALEYLASRGLEGEAQPRGWGEGGAHEAIRPVRPIDAQDLERAVLSGSIRIPIRLTRLHIRVYDMIFRRFIASQMKPATLDIVEATLQAGETVFNHAGVARVRGGYALVNPPRVEEWLARLSPGDRIDVEDVLVVKSSLKRLYRAGDIVKMMREHGIGRPSTYAKAIEQNRRHGYVIESKKMRYLIPTKTGVSIYDYLSNGFKKLVSVDTTRRLEEALERVEKGVEKPEAVLASVWRMVDEAVSLHAATGDVMGQSEA
(1272) DNA topoisomerase 1 [Aeropyrum pernix K1]
3
MVAEKPKAAAKIAYALSDGRGVLRCSEYGVPYWIVRRDGAAIVVAPSAGHLFGPHTDSRGFPVFDFEWRPIFEFDRGAGYLSKFYRMLSRILPGASLYVNACDYDIEGSVIGFKIIEAFGDVNRARRMKFSTLAPQDIRRAYARMERLDVEMIEAGMARSEMDWLWGINVSRALMEAARRAAGRRVILSAGRVQSPTLVEAYRRWREINLHVPKASVAVKITAEKGGGVFDARPHGWKPQSLETARSIKSELRKNPWLAVEEVRSERSILRPPPAFNLGDLQKEANRILGLPPLRTQSIAEELYLEALISYPRTNSQKLPPSINYRAILDKLAHGPLGREARELLKETGGVLRPVQGSKDDPAHPAIHPTGEKPSQRLSKEHMAVYELIVRRFLAAFSREAIVSKSSVLLRDFQGRVWRAEGLRVEDLGWLKYYHYSTPGEKPMPPLDRGDKARVVRVDVRVEWSQTPVRLDKASLLRWMESVNIGTEGTRARIIETLYKRGYLEGSRKSEVTPLGEAVAVIIQTLFPELSKPDLTRRFESMIEDIRSGRRTRQEVIDMSKKTISKLLESFLDRLDTAVREIGVSLGSVEVEAACHLCGRKAVSAVSGYRLCSHHMEAFDRLRKALPNLASTISSTPREALEAIARGRSRAGAWVRDVAALALRDDGLYKALL
(1407) Reverse gyrase 1 [Aeropyrum pernix K1]
6
MASARAASRGVYRYLCPNCGGPNSEERLSRGLPCPRCLPRLPRKGVSGWTGLARLLRREGTLGAGVKAMASLEEEARSLWRFFEKAVGSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAASLFYACKKGMRSYIVLPTTTLAANVARKLESMVESTGCGRVRLLVIHSKLKTSERREAMERFEKGDFDILVTTAAFARKYADRLSGYRFRLVFVDDVDAVLRSARSVDAILKIVGFDEEAIEKGLEVLRLQREQARLVGLLQSQREEVREEARKKLLEVKRRLERLEAEIEARRGRTASLIVSSATGRPRGARVRLFRVLLNFEAGGRGDIGLRRVIDSYTHPTDGVAEKVVELVRRLGTGGLVYVPIDMGVEYAERLAEELRRAGVKAEAYHAKKPLELLDRFAEGEIDVLVGVANYYGTLVRGLDLPARVRYAVFAGVPRHKFGSDIGDPHPSRLLRLLSILAESRIEEVASAARSHMGRLRRMLRVLSPAALQMIAERVARGEVEGGYDRQVLEAYQFLREALARDDVWESLRELDVGIVREGGRTYILVPDPATYLQASGRTSRLYAGGITLGLSVVVVDNEPVMRGLMKRVSWMAEVDWRRFEDLDLQSILREIDEDREKVRRVVKGLYRGVELVRTALLVVESPNKARTIARFFGQPSVRLLPGGGRVYEVATGDKILMIMASGGHVFDLVVRVDGRDLEAAGGEPEHAIFGVLRYRLGGNGAAAYTPVYTSIKRCLDCGYQFVDEASRCPRCGSELIRNSLSTVEDLRRVAWEADEVYVGTDPDTEGEKIGWDVALALRPYAPDIKRLEFHEVTKKAILEALSNPRSFDDNLVDAQVVRRVEDRWIGFTLSPLLWCDFWPRYCKRVLEEYGEKRPHMDRERCAKYKAYYNLSAGRVQTPTLGWVVDRTLAYRKKVWLYRVVHDSQLLFAVRSDDPEVPESVKRVLDNWVKHHKKTGIEPWLDVKAVVEKEEWTALPPPPPYTTDTMLRDANRLLGLGSAEAMRIAQDLFEWGLITYHRTDSTRVSDRGMQVAREWLETRFGGLAGQLYRPRRWGEGGAHEAIRPVRPIDVERLQLLVEEGVIELPGTLTRRHLRLYDLIFRRFMASQMREADALRVVYRLRVPELDGYTLTLERVVEIGRPGDAEGVTRGFTLVWPYVRPQPRLVEGREAWIRARVEGRQVPKAYPYTEGEIVEEMKTRGIGRPSTYAKIVETLFRRRYVIEVSREEGRGAGFVVATSRGINVYNYLTEELRSADEEEYGGRIAGILRRVPSLVSEDRTRELERQMDMVEKGDASRDDVLESVFNEISDLALLLNIEHPIKHRSRAEGNTQGNTWVSNFVACAVKSPEVSRVWGAGVG
(1348) DNA topoisomerase [Hyperthermus butylicus DSM 5456]
3
MVRAGYCSAGFGYTLVIAEKPKAARKIAEALSDKPIACKLGGIPYWIVTWMGTRYVIVPAAGHLFGLTTDKHGFPVFEYYWAPLWAVDSSSAHTRRFLEAIKKLARHAVRFVNACDYDIEGSVIGYNILRALGVEKRALRAKFSALTRQDVRRAFSRLERLDWDMINAGLARHELDWLWGINISRALMESLRSVTGRSKVLSAGRVQSPTLVEAVSRTIKRNLFVPLPYFTVTATVELGGKARRLQVASFELRSEAQRVARQLRATGYLVVREYSEYVERIPPPYPFNLGDLQVEASRILGFSPYYTQKLAEELYLEGLISYPRTNSQKIPPTIDISAIVQALVRQTRYRELVEYLLRATRGVLRVNNGPKEDPAHPAIHPTGEPPHSGLSKNHLRLYDLIVRRFLASMAPPAVLVRARLILSAEGLGSASITGVRIVSPGWMQIYYWAKPSEEYIPRLYRGQRIQVKSVSVQTSYTQPPELHTKTSLVKWMESKGIGTEATRARIVELLFERGYLRSEGGRVQATELGLTVANILQTYFPDITSVELTRRFEELLEAIRMGKVSKDAVISEARRFLAGILSEFKVKSMHAVGMELAYSLGLLKPPRQCPICGRRAEGEYCSYHEAAIRKIVEAYHEWRRRTGITCREYLEKLAAMRSTGKWVREAAKYLLARNVCPKGLTA
(324) Reverse gyrase [Hyperthermus butylicus DSM 5456]
6
MGELSTDYYERIETIGRLLAENGRLRGYWYLYSSTSQLREFEEFFEKLTGHKLWSAQRTWAKRMLQGESIAIVAPTGVGKTTLLSVYAVYRASQGLKVYYLLPTENLARQVTRKLETLSSRLGGGIRVVSYYSSLPKRAKEESLRTIEERSYDILVTTTAFLSRRWSLIEGIRFDSILVDDVDAVLRNSKNIDKLLQALGFSVEAIEAAYNLVKKKIMATIAKTSGNIKRYEKLLQDIEQLEAILSQELVKTTPGQLVIASATGRAYGLKPKLFRELLGFDIGRVYDYTRSIANLYKIVNDPVAEAVSLVTRMGGGGLVFVAKRFGKNVARRIAEMLNERGIRAAVALAGRRVLDRFASGEYDVLVGVASYYGVIVRGIDMPERIHYTVFVGVPSQAIEAGKALLSPHRIARSAVELSLEGAEELARRLSKLAPNEVTVLRIALERGERLEGRLGEILEMLLETRRKLLHAIEELVSIEGSVAVGGALYRFEDGKLVAILPDAPTYVQASGRASRMYGSAMTHGISIVLDVDEILVRLLAEKLKRFLEDVRFEELSSEKLAKELEKARASRRGGVGKKVDIETCLIVVESPTKAKTIAGFFGRPVRRRIGSVVVYETTFYNPVSGKIHVAAIAATAGHVYDLTIDDEGIYGVELGKNGVSPIYKPIKRCLSCGHQFSSSSQVCPRCGSSNIVSKEDVIGALRQLAIENEVVYIATDPDVEGEKIAYDIYLLLRPYARKIMRIELHEITRSELNRALANPREVDVRLAEAQMVRRIEDRWIGFGLSQHLWQVFGKNWLGAGRVQTPVLGWIIERYSEWRSNLGYNLYIRLPGGPLVKIHYDSASGAREAAAAAENGVRVVSVEEEVVEINPPPPYTTESLIYDASRLYGYPAQKTMRVAQELFEAGLITYHRTDSTHVSGLGQHIARLYLESREDAELLQPRSWGPQGHHEAIRPTRPIDAEALRRMVALGDLRVPVTLRESHYRLYDLIFRRFIASQMKPAKLKRRRIRLEVAGSQVEIEVYTAALREGYHKYYPYPRLHMALDSVKPGDVLRPERILVRRGSTVYLYTHGEIVSLMRERGLGRPSTYAKIIDALERHGYVIESKYRRRLVPTKLGIEVYEYLESRYGSLVSEERTRKLYRDIEEIASGNKSPVEVVNELLAELSELLETSLRQYTGEVKALG
(523) Reverse gyrase [Hyperthermus butylicus DSM 5456]
6
MKNYGGGAAARGVYLYSCPNCGGPVGDDRLSLGLPCPKCLPERTPAESVLDVAEALEKLGRLRRGSELEYYARVEREAREAEALFEKATGSRLWSAQRTWVKRVLKGKSFAAIAPTGVGKTTFGVLMAVYFAWRGEKSYIVVPTTPLVRMVEEKALKLADAAGVPARIIALHGRLPQKVKKELTMRVEEGDFDILITTSQYMIRNAEWLAGLRKRWGKGFRFVFVDDVDAVLKSGKSVDAVLRVVGFTPEEVELGWKLLQLQRQLVVASRRAQEQFLKELARLRQQARRKGKRLSAEEVRRLRRRIFEERLGRLYEELRRVEERLAEARRRAAVLVVSSATGRPRGSRVRLFQALLGFQAGSAGEAIRNIVDAYTYPGPEGIEAKVLELVKRLGDGGLVYVPLDKGAEYAERLAEYLREHGIAAEAFTSRNQAALDRFRAGETKVLVGVAVYYGVAVRGLDLPERIRYAVFAGVPRLKFSARFEDPHPVSILRALAVLAEHAPRDVADRAQALLGRLRAIVRRLSQAALAKIAEELRSETPASEYTRAFVEALEWLRGVLRREDVWEALEAADDIAVVREDGRAYILVPDVATYIQASGRTSRLFAGGITRGLSVVVVDDERLLNGLMRRTRWLVEAEWKRFEELDLPRLLREIDEDRERVRAIIEGRVKPEFMELVKTALLIVESPNKARTIASFFGRPSARQIGPLRVYEVSTGDYVLLVAASGGHVYDLVKPSTPKETVSPDWLLDQLSGSVEGYNWDTARNIHGVLAAEGGERRFLPVYAPLARCLACGHQWTISPEDYNPAEGRGELRCPICGSPLVKSSWDIVEALRDIATEVDVVLVGTDPDTEGEKIGWDIASLIRPAARSIVRIEFHEITRKAIVEALHSLRDFDQRLVEAQIVRRVEDRWIGFTLSPILWTKFWPWYCSWRLKRRLVQGRRMKNLQTALNAMERLASLAEECRRPNYNLSAGRVQTPVLGWIVEHTIGSKYLRIPLYRLQLEHNGSRLEVDVRGDEVSEEIRRALEETHRRLEEALKSHNVLEALEELEKLRRSKRRVILAVNQALREGGAVKARVSKVEEWEEELKPLPPFTTDAMLAEAAARLGIPAPEAMRLAQDLFELGLITYHRTDSTRVSDAGIAVARDYLRYRYGEEKLSEVFQPRRWGTGGAHEAIRPTRPIDAETLRRLVEEGALQLARPLTSRHYRLYDLIFRRFMASQMKPARVRKQKAVVELEFSIPGEKPVRIVREVEKTVEILEPGWLDIYPVVRTEQRLVEGDYRMAGISTRVWSPVQLLTQADVVRMMKERGIGRPSTYAKIIDTLQRRAYVVTSPRRGTMIATSRGIGVYDFLMKRFGSLVSEETTRKLQEIMDRIEEGLANYEDVLSQVLEELRGALEKPESGLTGDEARKLLPV
(164) Reverse gyrase [Acidilobus saccharovorans 345-15]
6
MCPNCGREITADRLEKGLPCAVCLPREPKSGDILEIGLELAKEGKLKGYSSLYLMEKSFRDFSKFFEEKYGFKLSSAQRSWARRLLSEESFSIVAPTGVGKTTLLMAYAAFKVMQEGYKVMYLVPTENLVAQTAGRLASMLGDKVAFYYSSLPKAQRSQMLDKITRGDYSVVVITPGFMVKNFDMLKKQSPFNLMIVDDVDSLLRNSKNIDRALILIGFDEDSIATAFKIVQEKLELVTLEASGRSEERIRQLQSDISSLSLKLSEKVLEGPKGQLVIASATGRPRGVKHLIFRELLGFEIGGGTDYLRNVVDTFLITASPVDSVVSLAKKLGKGGLIFISQAYGKAYVKELMDKLAGAGVKAVQAISNSRRAVEKLSSGEVDVAIGLASRYGALVRGIDLPEVIRYAIFLGTPAIKVELKTALLSPRRLLRALIFLEEKDSSFKEYREKLENLLKNFNVESNILSAAIRGEIEAKGRLEVLRELVLEASAKAVQALSNMIVKDGQVLRIGTMVLRREGPSIWLYSPDAPSYLQASGRTSRLYHGTMTKGLSVIVDNMKELVDAMEDRLRWMSQATFVEFNSVNLEDVTREIEASRSEKGERKQVNIVTELIVVESPTKAKTIANFWGRPAKRSEGRVSIYETTVVDQETGTVHLITITASKGHIYDLVIEGSDEVGNSLFGVRFNNAIQPVYTTIKRCLSCGYQFTENVDRCPRCGSTAIIDSKGIADTLRKLATQVDRVIIMTDPDREGEKIAWDLYLTMRPYNQNIYRSAFHEVTPRAFMEALRLPGSIDVNLVNAQMARRIDDRWIGFVTSQYLWLKMNKNWLGAGRVQTPVLGWIIDRYNEYKEVMGYKVRGLLPSGTPVIFYTKSSEEAEEASKLNVAVAVTEKVWTEDVNPMPPYTTDEMIFDASAKLGYSAELTMKLAQDLFYSGLITYHRTDSTRISEAGMAVAKQYLESHGLAQYYKPRSWGAGGAHEAIRPTRPLNAEEVERAILDGSLRVPMALSGAHYRLYQLIFERFMASQMAPATLEKASVTLRLGNLTQSMEVVIAVVKEGFTAIMRPKLETWVLRETNKEYEVPLTNVVMFKGSLIQPYRSGDLVMLMKKKNIGRPSTYAKVIEANLRHGYAVETKKLKFLIPTRLGIEVYRLLSSSPFSDMLNEEASRRLEESLDAIESGSQDAGSFIMSVREELFRKLSEANLRLR
(1265) DNA topoisomerase [Acidilobus saccharovorans 345-15]
3
MRSSRDCNIPQYYDVIIAEKPKAADKIAHALGSPFRCAIGRVPIYILNVNGTNIVVVSSAGHMFGPSTGVEGLPVTMIRWEPLWRFDRRSKYLRPYYEVLSRLVPKARYFINACDYDIEGSTIGYKIIEAFGDKSRAKRMKFSSLTAAELRQAFRRLQPLDVNNAMAGIARAELDWLWGINISRLLMKSYREVTGERLSLSAGRVQTPTLAEAIRRWVKINTHVPIPQPSLTARLLHKGVEFTAYPLGWSVSTVKEAREVAKEVKEGMYMEVISLSRASESVRPPPPFNLTDLQKEAARIYGLSPYKTQEVAEDLYLAALISYPRTNSEKLPPTLNYREVLDSIGRQPKYRGLVGDLLRETGGVLRPREGPADDPAHPAIYPTGEQPTRLDRVHETVYDLIVRRFMAAFAPPATLSTVSAVLTDVKARRWEARGLNVAERGWLKYYPFHKFDESQLPTLNRGDRPLVRSITVKVSWSGPGLRLSRLSLLEWMEANDLGTKGTRARIIETLYKRGFITSRGSHAEITNLGYAVYKVLSEVAPELMSVSLTRDFERMLDEISMGKASREEVVSRAKKYISELVERQLNSNNIKVMGTYLAEFIGKVRPRSRCAICGRPTDGQSLCELHLAAKSNLEKSIDEVARRLGVSKEEALRRISNNRLAGKWVRDVAALMISGKERP
(1329) Reverse gyrase [Aciduliprofundum boonei T469]
6
MIPVIYGELCPQCHDKLSWKEIENNLCENTGKELSRTRESEIYGEFEKFFVEKFGSKPRAIQRMWARRVLAGKSFAAIAPTGIGKTSFGILMSMFLARKGKKSYLLVPTTIILKDMVKKFEDLGEDIAFYHSKMKGEEKKGMENRIKEGKFNILITTTAYLARNHKNLYGKFFHFIFVDDVDSLLKRSKNLEKVLKILHKKGVLMVSTATGTKGYNTKILRDKLGFDVGNMRNAVRNIEDIYASKDTLKDILNAMGSGALIFAPTAKEAKTLADRIGDKAGLVIEKDKRAYDDFQAGKLDYLVGVSTPYGSLIRGIDMPDRIRYVIFYGIPRFKINAENLDDFGDKLMLSLAYGLRDYGFDEYIKNRNVKEIREKLKSILQNRKDIRGEDFIYKNGHIIFPDVKTYIQGSGRASRLYAGGITKGASFLLDGDDMVEIFLQRAELYGIEFKSLEDVDIESLKREIDRDRRRIAEKVEEKDVITPSLFIVESPNKAKHIAHFFGKPNLRIIGNAVVYEVAVGDRVLTIAPSLGHTVDLSTTQGYYGVVIKTGLFIPVYSPIRKCRDCGYQFTEGNKCPVCGSEDIYNAREQIEILRRLAYECEDVIIGTDPDTEGEKIAWDLRNLLSPFAKSIKRAEFHEVTKDAIIKAIRESREFDENLVKAQIVRRIEDRWIGFELSHILWNLFGKKNLSAGRAQTPVLGWIIERYEKSKEIREEYFIKGTDVKSPWKENVLAKVEKIGDEVKDYVVPPYTTDEILKDANTILGLGAREAMNILQDLFESGLITYHRTDSTHVSQEGMSIAKKYLGEDFRPRRWGKEGAHECIRPTKPWSAEDIRRFVNEGILNLEIQDEALRVYDLIFRRFMASESVGKIRISKYKVSAKGKVLEIPLIVEAYGKSVELYPYRIKVYRPLPTGMVRIEVEKRKIKLAPYTQADVIRLMKDRKIGRPSTYATIISKLFKRDYIVERSGKLIPTRIGIEVYSFLSTNYGKFVSEERTRILERKMEDVENGNRDYLYVLNELYEEIGKIRGN
(1130) DNA topoisomerase 1 [Aciduliprofundum boonei T469]
3
MNILVIAEKRNAAQRIAKILSGGRYETIKKGRNAYYSFTKGKDRYFVVPLRGHILHMDYPDKFKRWSLGDLQRLVDEEPIKIIKEKGIANILRTLAKDADMLIIATDYDREGELIGVESLSITNFKGPVKRAKFSALTEREIENAFSNLVDVNYNLASAAETRQKIDLAWGASLTRFISLASSRRGKDYLSVGRVQSPTLALIVKREKEIENFVPTPYWNIKGLFFKRRNFSGMHISNPFWKEEEVMEVYEKVKDTKSAKVLDFVQEDRKIRPPIPFNTTEFLSEATKLGFSAAKAMRLAEELYMGGYISYPRTDNTVYPKTLSINSILKSLEKSKFKEEALKLQKERRRYPTRGKKESTDHPPIVPTRGANLEGDKGKIYELVVRRFMATLAQDLEYRESKVKLAVKDEIFEAKGKELVNEGWLYYYPYVRFEEEKIPILRIGDEVKVKKIEIERKETRPPARYTQSSLIREMEKLNLGTKSTRAEIIQKLFERGYVRGNPIRPTQLGKALIESLEGNNVDVIKPDMTARLEMDMDEIEKGSKAPEFVVKESREMLKKILSSLEENRSTVGSNIKSSMRREIGECPDGGKLIYLERKRLVVCENDGETKYYNLPKTGHIEFLDKKCPICGLPLIKIIRRGQSPEIRCLNSKCEYNRKKDIVGKCPKCGGDLVIRQSKNGKRFIGCSNYPKCDVTYSLPQRGKIIPTGEVCPYCGAPLLILRKKGKKDWKFCPNIKCEYNRRNKDEK
(1131) DNA topoisomerase 1 [Aciduliprofundum boonei T469]
3
MNILVIAEKRNAAQRIAKILSGGRYETIKKGRNAYYSFTKGKDRYFVVPLRGHILHMDYPDKFKRWSLGDLQRLVDEEPIKIIKEKGIANILRTLAKDADMLIIATDYDREGELIGVESLSITNFKGPVKRAKFSALTEREIENAFSNLVDVNYNLASAAETRQKIDLAWGASLTRFISLASSRRGKDYLSVGRVQSPTLALIVKREKEIENFVPTPYWNIKGLFFKRRNFSGMHISNPFWKEEEVMEVYEKVKDTKSAKVLDFVQEDRKIRPPIPFNTTEFLSEATKLGFSAAKAMRLAEELYMGGYISYPRTDNTVYPKTLSINSILKSLEKSKFKEEALKLQKERRRYPTRGKKESTDHPPIVPTRGANLEGDKGKIYELVVRRFMATLAQDLEYRESKVKLAVKDEIFEAKGKELVNEGWLYYYPYVRFEEEKIPILRIGDEVKVKKIEIERKETRPPARYTQSSLIREMEKLNLGTKSTRAEIIQKLFERGYVRGNPIRPTQLGKALIESLEGNNVDVIKPDMTARLEMDMDEIEKGSKAPEFVVKESREMLKKILSSLEENRSTVGSNIKSSMRREIGECPDGGKLIYLERKRLVVCENDGETKYYNLPKTGHIEFLDKKCPICGLPLIKIIRRGQSPEIRCLNSKCEYNRKKDIVGKCPKCGGDLVIRQSKNGKRFIGCSNYPKCDVTYSLPQRGKIIPTGEVCPYCGAPLLILRKKGKKDWKFCPNIKCEYNRRNKDEK
(1330) Reverse gyrase [Aciduliprofundum boonei T469]
6
MIPVIYGELCPQCHDKLSWKEIENNLCENTGKELSRTRESEIYGEFEKFFVEKFGSKPRAIQRMWARRVLAGKSFAAIAPTGIGKTSFGILMSMFLARKGKKSYLLVPTTIILKDMVKKFEDLGEDIAFYHSKMKGEEKKGMENRIKEGKFNILITTTAYLARNHKNLYGKFFHFIFVDDVDSLLKRSKNLEKVLKILHKKGVLMVSTATGTKGYNTKILRDKLGFDVGNMRNAVRNIEDIYASKDTLKDILNAMGSGALIFAPTAKEAKTLADRIGDKAGLVIEKDKRAYDDFQAGKLDYLVGVSTPYGSLIRGIDMPDRIRYVIFYGIPRFKINAENLDDFGDKLMLSLAYGLRDYGFDEYIKNRNVKEIREKLKSILQNRKDIRGEDFIYKNGHIIFPDVKTYIQGSGRASRLYAGGITKGASFLLDGDDMVEIFLQRAELYGIEFKSLEDVDIESLKREIDRDRRRIAEKVEEKDVITPSLFIVESPNKAKHIAHFFGKPNLRIIGNAVVYEVAVGDRVLTIAPSLGHTVDLSTTQGYYGVVIKTGLFIPVYSPIRKCRDCGYQFTEGNKCPVCGSEDIYNAREQIEILRRLAYECEDVIIGTDPDTEGEKIAWDLRNLLSPFAKSIKRAEFHEVTKDAIIKAIRESREFDENLVKAQIVRRIEDRWIGFELSHILWNLFGKKNLSAGRAQTPVLGWIIERYEKSKEIREEYFIKGTDVKSPWKENVLAKVEKIGDEVKDYVVPPYTTDEILKDANTILGLGAREAMNILQDLFESGLITYHRTDSTHVSQEGMSIAKKYLGEDFRPRRWGKEGAHECIRPTKPWSAEDIRRFVNEGILNLEIQDEALRVYDLIFRRFMASESVGKIRISKYKVSAKGKVLEIPLIVEAYGKSVELYPYRIKVYRPLPTGMVRIEVEKRKIKLAPYTQADVIRLMKDRKIGRPSTYATIISKLFKRDYIVERSGKLIPTRIGIEVYSFLSTNYGKFVSEERTRILERKMEDVENGNRDYLYVLNELYEEIGKIRGN
(1236) DNA topoisomerase 1 [Methanococcus vannielii SB]
3
MTGLIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGEDIIVASAVGHLYTLQEKEKTKFGDYPVYDIEWVPASTLDDKKYIQKYIDTLKKVSKEASKFYVATDFDIEGELIGYHALSHACGQKNAHRLRFSSLTKKEIIKSFENPNQIDFGLVDAGDSRHKIDWYFGINVSRALMQAVSSAKRWKTLSTGRVQGPALAFLVDKEIEIKNFIPTPYWVLEAVLDNNLKALHELEKFTDEKRAKEAYEKVKNEKEALVTEIKKTLKSIPPNVPFDLGALQREAHNVFRFSPKKTQEVAQKLYEKGYCSYPRTSSQKLPDDKAYMDEVLKNLSKNKEYSKYIELILSEGRKPVDGKKDDPAHPAIHAVDVPKENLPDDELKLYELIARRTIALYLDDAKREYSKISLEINGEPFKLNGSRTIEEGWHELYYFTKFDEIELPTLKKKDLLRINEIAFEEKETKPPKRYTMASIIKELEKRTLGTKATRADILEKLTKRGYVIDDGSLTVTELGIGVTETLRKFCPEIVEETLTRDLENKLELIQDKKIKKETVIKETKDKLTKILGEFKLKEKEVGNELVEKLDSTNRSMQVIGKCKCGGDMIIIRTKGKKRFVGCSNYPECEITFPIPQKGRIKVINEVCKTCENPIIGLDSIKICVNPDCKTRISEEDRKEMEKAALEEKSCPKCGGKLSIKKGPYGVFRGCENYPKCKYTEKLNGESNEKEVIGKCPKCGNDLLKRKGRFGDFIGCSNYPKCRYTEKIEKKKEGDLEDKIEVTKEKVKAKETLKSEKNLDKTLDNPKPKRTKTASKKKKEELKN
(1570) DNA topoisomerase 1 [Methanobrevibacter ruminantium M1]
3
MHEVIISEKPKSAEKIAKALSPNAQKKKYNRKINYWEFEENGKKTTVLSAVGHLYSLTSASSRDRLGFDLTWVPAYEVEKQKYTRDYINAIKKLSKGADKFVHACDYDVEGTLIGYNALKYACGNNAEAKASRMKFSTLTKKDIVEAYNTMRDIDIRQVDHGIARHMLDYYYGMNISSALMKAVRASSSRFISLSAGRVQTPTLSILVDREKEIQSFVPEPYWMIKAKSDYDIIADHVEGKIFDEERAKKIYADCQGADADVTSVKVTESIRKPPIPFNLGGLQSEAHTVFGFSPKRTQVAAQNLYVGGYTSYPRTSSQKLPESLDFKNIFAGLAKDPEFKKHIFDLPAKLKPNEGKKTDAAHPAIHPTGVLPSNLSADEAKIYSLIVYRFISVFSENSKLETMKVNLKVADEKFTFSRKRVSYEGWLKHYPFKKQENDAFPPINKGDQLKIHKILVEEKETKPPARYNEASLIKELEKRELGTKATRADIVAKLYDRKYIEGKKIEVKPLGINIIDTLNEYCKDLTSEELTREFERELEGIDTDKYTKEQILENGEKEVKTILAEINQNKKQIGEKLYGAYQETNVVGECSCGGKLIKRYSPRTKNTFVGCSNFPKCKVTYSLPKGANMLKKTCPTCGLPMISIKKASGKGRDHVCLDSNCGKDVSRRQAPEVVGKCPECGKDLLKRSGRYGEFVGCSGFPRCRFTCSVDELNNLGKDKNKEDVKENKGVSKKIVRSEAK
(1782) DNA topoisomerase 1 [Methanothermobacter marburgensis str. Marburg]
3
MHEVIICEKPKSSEKIAGALFPDAERKKYRKVSYWEYSEGNKRVTIVSAVGHLYSLRPSKPGEEHFFDLEWAPLHEIDKKKNYVKDYLNVIKKFAAGADRYIHACDYDIEGTLIGFNAIRYGCGEDALQKTVRMKFSTLTREEIQSAYEKPIELDCGQVDSGAARHILDFIFGVNISRSLMKSVKEATNRFIKLSAGRVQTPTLAILVEREKEIREFEPVPYWIIQAELESGIVAESRRGKIFQRPLVDEVLERCSGSDASVRGVKVRDTVRKPPVPFDLGSLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYRKILDRLSEDPRFGAHIEGLSEPLKPHEGKKVDDAHPAIHPTGLLPSDLSSDERKIYELIVHRFISVFGEDAVLQTMRVDLEIGGEEFSFSRKRVSKRGWMDSYPYTRIEDEVFPDISEGDVMGVVGVSTLEKETKPPARYNEASLIRELEKRGLGTKSTRADIIAKLYDRKYIEGKKIRVSPLGENIIDTLTKYCEKITSEELTRQFERELEEIMEGKISRDRVVDEAIEEVKSILSDIERNMKDIGRDLYKAYQDSRVVGECPACGRNLVIKYSPRNKSTFVGCSGYPDCRTVYSLPRGASVLKSRCEKCGLPMISYGRPRQRACLDPSCGKKESKGEEIVGKCPECGSDLIKRSGRYGEFVGCKGFPRCRFTCSVDDVPAA
(85) DNA topoisomerase [Desulfurococcus kamchatkensis 1221n]
3
MVSKSIRIWDLKGRILVIAEKPKAAKKIASALSPTHNAKRIGSITIYEVDSYSSSIIIASSVGHLYQLHTSLRGYPVYSYEWIPLHLTDPSKKYIREYLEVLGKLCRGVDYYVNACDYDIEGSVIGYLIIKFNGDERKAFRARFSSLTIEELRKAFNNLTRLDYEMIEAGLCRHELDWIWGINVSRALMKAVEDAVGERIILSAGRVQTPTLKYVVDKVVERNLFIPLPQYNINITVEKNGEKIRLEYTGNPVEKERDARDIVEKIRGYKYLIVSKVEKKHHILHPPPPFNLGDLQKEAARLYGFSPAETQSIAEQLYLDALISYPRTNSQKLPPTLDYRRILENISSIKSYRNLVESLISETKGVLTPVEGEKEDPAHPAIYPTGVVPGRLTEKQWAIYDLIVKRFLAVFAPPAKIVYYVVKATTPSHEYVFETKGQVIEEYGWLKYYNFHNYHAGKIPVLKEGELLNIVKATASESYTKPPKRLTKTDLLRWMESVEIGTEATRAQIIEKLFERKYLYQHQKSSGIDVSEIGFGVVEILEKFFPDLLSVELTRKFEKEMDSIRSGVKRRSEVLEEARRVLTELLGKFDRNRIEAGKQLALRLKIIQNTRKCRVSSCYREGVVNGLCSHHANAVKLVREYYGEWSRRKDITFNEYIDKLRKSKLTGKWVKEVIESELT
(848) Reverse gyrase [Desulfurococcus kamchatkensis 1221n]
6
MPGAFNPLYKGFCPVCGGDILSSEVELRGFCSRCANSGLTSILRDIASSGLGDFEEFFRRASNGLSVWGAQKIWAKRLVSGENTVLIAPTGMGKTTLLIIYSLYAARRGKRVVYITPTRTLLTQIHRRLVEAAERTGINGVNLIAYDSSMSKKKREEVLSRIEKGEYSILVATNGFLSRKSELLSRSRPDIVIADDVDSVVRSEKNVLRLLRILGYSDEVIELAKKRISLLWRLMVNKAFNNNDKYAELVKEYIEVDSLIEKTLSSTRHAQFIVASATGRMKGLMGRILKELLHVDISGVTIYGRDVTDAYMLIKPGELHGELVRIIEKLGPGGIIYIAPHHPFKNMLKEELDKAVNILADKGFRIGDATPGNVARLIKGELDILTGSASYYGSSVRGIDAPEAIRYVVFIGSPVFATSLESLLANPGMMIRVLLELVDSNDARNRVLELRRLLYTLTPGEVRLVKLALTGKILEEALQASEKLYSKYQVIKQYYRETLERTRSILDEKGIMDIGTLTLVRAGGDYYALIPDVMTYIQASGRTSRLYGSRMTHGLSIVFEYRALYNTVKGLEARLKGLNKELVFIDLASVDLDSEIKAIESSRRNNDSSPGMSYRSILVVVESPTKAKTIARFFGKPVARKLGDVTVYEIPVKIGGEIIHLNIVPTRGHIFDLTTGEEGYYGVVIADNRVTPVYEYIKKCRLCGTQFTTGDHCPRCGSRLFSDSRTIVAALRKIAGEVDEVYIATDPDIEGEKIAYDVYLAVKYYNEKVWRIELHEITLQEFLKAINNKRGINQRLVEGEIYRRVLDRLVGFKLSQELQGIYGLRFLGAGRVQTPTLGLVIDRYEEYMRNKCKKIRFKLGSPLNIIYSVFMGKNSEVIRELKTAKMLKLVRVGREIVTITPKPPYTTDELLSDAAKLNLHTGIVMSIAQQLFEAGLITYHRTDSHYVSNTGIGIAMKYIEGKKLEDYARPSHWGSPGTHEAIRPVYPYDLDDLLKAVSEGVINTVIPLTGMHLKLYDLIFKRFISSQLKPFKAVKSIYAVYFGEFKLGEIELLTNIVEEGFNVFEKTRVYKELDAVESIEVPVEEISVVDSSKSPLFTEGELVSLMKKLGLGRPSTYSKIIESIKRHGYVFVSKKRLKLIPSKRGIEVYGYLRDRYPELVSIEATRRLEESIDKIINGEVDALVYLTDIGSRLNMFHSINMVNRGDFASTSS
(709) Reverse gyrase [Desulfurococcus kamchatkensis 1221n]
6
MINLKTLLENFREFKPHGIYRHACPNCGGPIDDYRLIFKAPCSKCLNEARFKAVIKDLNGEITRFQLLKLYYDKLNKKLKKSGDLKKLMDNERMLNDFEDFFEKAIGFKMWSAQRMWARRILKGLSFSIVAPTGMGKTVFSLIATLYLVSHSRSKNREQRFYLVFPTTPLLLQAERKIKDFSRNLGINVCMDDNWGSNCLRILCIHGQQGKKEKEAALTRLKEGDFDILLTTSKFMHKYYELLKNKNFKLIVMDDVDAVLKSGKAIRRVLNIIGIEDEYIDKALTLIKARSKLAVLSSEEKSKLEKEVESLEKEISTVKQNINTILLVNTATGRPRGIYPKLFKIFMNFEAGSKPEAIRNIVDTYIESIRDIEEKMVELALKLRDGLLIFVPVDRGVEYAEKIASLLKEKGLNAEAFHSGKPAKLLDAFARGEINILVGVATYYGVMVRGIDLPERVKYIMFIGVPRHKFTPELEELSPRDLLRILSVLRDASEGERKEAIDRLIGRLSSRIRRMSPGALMMIREELAKKLRGEPVEETPFLRDAMEAYKIIKEELSKDETWHKISSLGDIGVIREGNKYYMLIPDVATYIQASGRASRLYPGGITRGLSITLVDDKRLLNGLVKRMRWIFEDFNMVSLDQVNLEELTRQIEEERRRVAEVIREGIKTTTQVEPVKTALMIVESPNKAKTIANFFGKPSIRVVKDVLQAYEVTVGNYVLSIVASAGHVYDLITDNPGESMGENLYGVLKIENRFIPVYTDIKKCSNGHQFTDEVIDNTNECPKCRINGKVSHVTRKLDIVKALRELAEEVDVVLIGTDPDAEGEKIAWDLRVLLEPYASDIKRIEFHEVTRKAILNALKNPRDFDLKLVESQIVRRIDDRWLGFSLSEKVQKYAWLKYCSEYLKNKTVKEEKDDSELHEFDCCTQNRNLSAGRVQTPVLEYIVKETEERRKPERWSYRIKIYVEDVGDFVEVTIPYIDAEELGVIKSLNKKKLLPVEIIVIGEDVEEVNPLPPFTTDALLEEASRSLRLSAVRAMEIAQNLFETGLITYHRTDSTRVSDTGISIARQYLEEKYGEKAQFYFKARMWGEGGAHEAIRPTRPIDADRLLELIKEGVLTLSVKFTKDHIRLYDLIFRRFIASQMRPAKLRKLKFKVVIKNREYYSEVYTEAVEKGYLEVYKNIELVQGIRLKPSEPGGRINGKIHEGEVIKPPMLRFHDVVRWMKENGIGRPSTYAKIIQTIIDRRYVIVSGETKALIPVERGRYVLKFLKDHYGDIVSVDTTRRLEDLMEKISRGERDYQEVLEEIYREVKNIVLENKDINDSLEKEYNERCASTT
(653) DNA topoisomerase 1 [Methanothermobacter thermautotrophicus str. Delta H]
3
MRSLSGKMHEVIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHLYSLRPRQSNEEHFFDLEWAPIHEIDKKKGYVKDYLNVIRKFAAGADRYIHACDYDIEGTLIGFNALKYGCGEEALRKTSRMKFSTLTREEIQRAYKNPIEVDYGQVDSGAARHILDFIFGVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRDFKPVPYWIIRAELGEGIIAESKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKPPVPFDLGTLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYEKILKNLAKNPRFGVHIERLRGPLKPHEGKKEDDAHPAIHPTGLLPSELSKDEKKVYDLIVHRFISVFGEDAILQTMKVELEIGEEEFSFSRKRVSKAGWMESYPYTKMEDEEFPEISGGDSLAVRSVSADERETKPPARYNEASLIRELERRGLGTKSTRADIIAKLYDRKYIEGKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELEDIMRGKISKDRVIDEAITEVRSILSDIEENLRDIGKELYRAYQDSRVVGECPACGGKLVIKYSPRNRSTFVGCSSYPDCRTVYSLPRGASVLKSLCEKCGLPMISYGRPRQRACLDPKCGKKKSEVEEVVGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCSVDEVPEG
(617) DNA topoisomerase 1 [Methanobacterium paludis]
3
MHEVIICEKPKAAEKISSALSKGAAKKHYKKVPYYEFEENGKKTTVLTAVGHLYSLAPKDKKQDKLFDVEWVPLYEKDKKKKYVKNYIDAIKKLSKDADTFVHACDYDIEGTLIGYNALKYACGDESLKNVMRMKFSTLTDEDILKAYKKPMELDFKQVDSGIARHVLDFFFGVNMSKHLTDSVMKATKRYIQLSAGRVQTPTLSILVDREKEIKEFIPVPYWLIKADLDVTGVKEGITADHKKGKILEKKDADAILVECKGKDAVITEVNLRKTTKTPPFPFDLGSLQSEAYGVFGFSPRKTQQIAQNLYTEGYTSYPRTSSQKLPKSIGYDKILKKLSYSSAFGNHVAQLKKPYKPNEGKKTDEAHPAIHPTGVLPKELSTDYRKLYELIVYRFISVFGENATLETMKTTLTIGKEEFNFSRKRMSKMGWMGHYPFRKIEEDYFPTMNKGETLNVKEVRAEDKETKPPARYNQASLIRELEKRGLGTKSTRANIIDILFSRKYVEGKKITVNKLGEQLIDTLRKYSKKITSEELTREFETKLEGIMEGKDKKDKIIDEARVEVSSILDDIEKNKLKIGEELYKSYRESRVVGKCKCGKNLILIDSPRGSTFVGCSGYPECKSTYSMPRGATVLKTTCEECGLPMISFGKPRQRACLDPKCGKDGREPTNEVVGKCPDCGSDLIKRSGRYGEFIGCSGFPKCRFTKSIDDDGGKTAAKTTGAPKKTVAKKAATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKNAKKTK
(1360) DNA topoisomerase type IA central domain protein [Caldivirga maquilingensis IC-167]
3
MDKLIVAEKNSVAKAIAQYLAEGGYTLRRIGIVPVYFFKVNGEYWASMGLRGHILDFDFEHSYNNWNRVEPGKLLDLEPVMVIRGWDRPYVTALVELSKQAREIILALDSDVEGEAIAYEVMLVTRLRKPTLRFRRALFSAVTRDDIRRAFSKLTTINVNLARKVFTRMVIDLKYGATFTRLLTLSAKSSKAPLNRGEFLSYGPCQTPVLNLVVQRALERENFKPEVYYKIKLIIEANGELIELESIDKFKNLKEAQEALSRVKAGKAVVKNIEAKRVHVNPPKPLETVELERRASRFLNIRSKQTLDAAEELYRQGYISYPRTETNIYPPTLDLRGILRNLTSTSTYGQYARHLLAGELRPTAGKDNDNAHPPIHPVKAADKPELMARFRDFKYWLIYDLVVRHFLATLSPPALIEEQRLTVDAGGVLFEASGLRIINDGYFTIYPFERPRANPLPLSALRIGMQVTVKDAKVVKRKTTPPPYLSESELLRLMRKYGIGTDATMQDHIHTNVKRRYFKIIKGQCVPTPLGKALITSLSKYAPTLIDPNFRSRMESMLSLIGSGKEMPDSVRRRLEEEAARVYTSMKPNSNQLGEELAKALRSMVNEKGA
(4) Reverse gyrase [Caldivirga maquilingensis IC-167]
6
MRDNKGDGGSGEPLVLYHGMCPNCGGPVTSDRLRDGLPCHVCLPEGSRLRAASLRVVLSELNREGRLVRLRDIFNYLMKYDEFSELFRKATGTSMWGAQRFWAKRLIKGKSFAIIAPTGSGKTTFGLVASIYVASKGGRVLMVFPTSTLAYQVYKRALTYRDSAAVNIKVITYNGLLSEKDKSEVLNAIKAGDFNILIVTNAFLPKGMEILSKYRFDLVFVDDVDSVMKASSRNIERLLQLLGVPREAIDKALEIAKISDFKEREGKVSELRRILEGRRIGSLIVSGMLTRTRRTARAALFREILGFDVGGRAEGLRNVVDLYIKPKGDLKVIILDLIRRLGDGGIIYVPTDLGREFAEELSKFLNDNGINAGLYLKPKRKLIEGFEDGSIPVLIGLATSRSALVRGIDLPHRIRYVVFAGVPKIRFRLSLKEFNPGRYIMLLSSLRVIAPSEYKTRIDKTVSSLRNIMNLSQDRINKIIEAIERGESLQGFDKYASEVISNAIKLAQDLLNRDDVREAMSKSIVNIQRMGDDIYVILPDSPAYIQGSGRTSRMYLGGITHGLSVLIVDNEAVFNSLSRDLRYRLVDFQFINYEEFNVDALLKTINEERELIRQIMTGNVPQSISQVDPLKSVLVIVESPTKARTIANFFGKPSTRVLGSLIVYEVTSGNLLLNIIATKGHVVELATEQYAQSVSSDVDYVTKFISSVTRNYYSVLKIDGNFIPIYSTIKRCPTCGRSFTDDVSKCPFDGTPLVDSSGVIEMLRDLATEVDLVLVGTDPDSEGEKIAWDVFNMLRPFVQDIRRIEFHEVTKRAILNALANPRGVNGNMVKAQLVRRIEDRWIGFGLSSYLQRAFNDRNMSAGRVQTPVLKWIIERYIEYRRNRVIRLIVRKRISDGKVLEVSFDKVTNGDETARVRHDLRDVAKDKKGLRIIITKLSESEEEVNPPPPFTTDSMLTEATARLRAGTEEVMRLAQELFEMGLITYHRTDSTRVSAVGISVAKEYLTNRFGEGVFTAREWGMGEEGAHECIRPTRPIDSEELRSLIDSGVLKLKLTNRHIALYDLIFRRFMASQMQSGLVKKVKVEVKLMRNGDMLSSRVDEFVTSVIRNGFLAIYPTIRVTQFPESSMELPVTEEDEVIVKTVHTTYPYREGDIVAEMKRRRIGRPSTYAKIIETLKRRGYVKALGSTKVLIPTKRGVAAYICLSNDKDVAKLYLSTRRNKVQENTEFESLLKQCNVNFKCLISEDRTRMVEEHMDNIENGDEDYLTVLHELFNEAVKYGIMPQN
(775) Reverse gyrase [Desulfurococcus mucosus DSM 2162]
6
MLRSVDPLYKGFCPVCGGDVSASELELYGSCKKCSRSSLTPVLRDIVAGDLDDFSGFFSKATNGLSIWGAQRIWSKRLVSGENTVLIAPTGMGKTTLLIVYSLYAARRGKRVVYIAPTRVLLTQVYRRILDAASRIGLADSMILMYDSSAGKKKREEALARIKQGDYRILVVTNSFLSRKTDLLLPVKPDVVIADDVDSIVRSEKNIVRLLRILGYTDEVVELAKKRISLMWRLMVNRAFNSEEKYAEAVKEYIEVDSELEKKLAETPRSQFIVASATGRMKGLMSRVLKELLHVDISGVTIYGRDVTDSYLLIKQGDSGRGVAELIERLGPGGLIYVAPRHPFKKELEEILGNVLKTLSSKGYRIGEATPGNVMKLVKGDLDLLVGSASYYGSSVRGIDAPEAIRYVVFIGSPVFAVKLEALLANPNMMIRALLEIANLAGDPGARGKAADLRRLVYTLSPGELRLVKLALSGKIPEETLSSSERLSSRYPEIKNYYAETLAKVKSILDERHVVEMGSITLVSVDGDYLALIPDVMTYIQASGRTSRLYGLRMTHGLSIVVEYEPLANTVRGLEARLKAINRELGFTDLRGVNLEHELELIASTRRGGGASNGLKYRSILVVVESPTKAKTIARFFGKPVARRLGDVSVYEIPVKLGDEIVHLNIMPTRGHIFDLTTDNEGYYGVLINEGGVSPVYESIKRCRLCGTQFTSGETCPRCGSRVFTDSKTVVAALRKIAGEVDEVYIATDPDIEGEKIAYDVYLAVKYYNEKIWRIELHEITVQEFLKALGSKRGINTLLVEGEVYRRVLDRLIGFKLSQELQSMHGLRFLGAGRVQTPVLGLVIERYRSFLRNRCKRVSFKLGAPLNTVFTILVDKGSELPSKLKDARVLKLVRTRREEVVVSPKPPYTTDELLADAARLGLPAGTAMMIAQQLFEAGLITYHRTDSHYVSNTGISVAVKYMEEKGFSRVARPSHWGSQGTHEAIRPVHPYDVDDLLKAIAEGLVNVVIPLTGLHLRLYDMIFKRFISSQMKPFKSVKSTFAVYYDGLKLGEVELLTRIVEDGFNLFEKVKVHSELDDVESLDVSVEDVVIADSSRIPLYTEGELVSLMKQLGLGRPSTYSKIIENVRRHGYVIASKKRLKLIPTKRGMEVYEYLVSRYPDLVSVETTRRLEESIDRIGKGEVDARTLLTEVCSRLNIWGKPVEGATSISS
(925) DNA topoisomerase [Desulfurococcus mucosus DSM 2162]
3
MVSGVEPWMSRGVRIWDLKGRVLVIAEKPKAARKIAEALSPGYVTRRIGSIPVYEINAYGSMILVASSVGHLYELNTGVKGYPVYSYEWVPSHLVNPGKRHAREYLEVLKKLCRGVDYYVNACDYDIEGSVIGYLIIKFNGDEEKALRAKFSSLTREELRQAFNNLAKLDYEMIEAGLCRHELDWLWGINVSRALMKAVEDATGRRIVLSAGRVQTPTLKYVVEKTVERNLFIPLPQYRVTVTAERNGEEVVLEYAGNPVEKHGEARSIVERVRRQGYLIVEEVEGKTYVLKPPPPFNLGDLQEEAARIYGFSPAKTQAIAEQLYLDALISYPRTNSQKLPPTLNYRGILDNLASIGKYSGLVASLLSETRGVLKPVEGEKEDPAHPAIYPTGMKPGGLTDEQWAVYDLIVRRFLAVFAQPARLTHYTVKAVTPSRDAVFKASWQRVEEQGWMKYYGFHTYKSSRAPGLVKGDKLGVVKVSMRESYTKPPKRLSKIDVLRWMESVEIGTEATRAQIIEKLFERKYLFLESKGIGVSDLGFGVVEVVERFFPDLLSIELTRRFEKEMDAIRRGLRSRGQVLEEAKRILTAMLGEFDENRVEAGRQLAVRLGVAEPSRGKCRISSCKREAVEEGLCRHHASAARLIHEYYVEWSRRKEIGFDEYVEKLRKSRNTGKWIKEVIEAGVVKAPRFP
(1012) Reverse gyrase [Desulfurococcus mucosus DSM 2162]
6
MPDLPGSPSLPDGFKTHGVYRHACPNCGGPISDYRLIFKAPCEKCLRDEEFRGIVELAGKRGGIDRFQLLRLYAESSREGALRELVKREEMLRDFEAFFEKATGFKMWSAQKTWARRVLKGLSFSIIAPTGMGKTVFSLVTALYITQRARREGDPRGWRSYLVFPTTPLLLQAERKLRAFAENLGVSICSNDNWDNGDCIRILCIHGHLGKRDRETAMNRLKEGSFDILLTTSAFIHRNYELLKGKGFRLIVMDDVDAVLKSGRAVRRLLGIIGVEEEHIEKALTLVKARSRLVAASGEERARLEEEIRGLENEVSSVRSRINTMLLVNSATGRPRGMYPKLFKVFMGFEAGSKPEAIRNIVDSYVEPQGGIEEELVKLVLTLRDGVLVFVPVDKGVEYAERIVELLREKGLRAEAFHSKTSIELLDAFAKGDVNVLVGVATYYGVMVRGIDLPERVKYVVFAGVPRHRFSSMLEALSPTDILRVLAVLRDIAEGEKRDLIERLLGRISSRLRRMSPGAVLRLREELARKIRGESVEETPLLSTLFEAYKVIAEEFSKEETWQRISGLGDVGILKENDKYYMLIPDVATYIQASGRASRLYPGGITKGLSIVVVDDKRLLNGLVRRMRWIFEDFTMTPLSQVNLEELMKQIEEERRRVSEVIKGGTAAGTWVEPVKTALMVVESPNKARTIAGFFGKPSVRIVGNILQVYEVTIGSYVLSITASAGHVYDLVTDKSLPEAEGAEALYGVLRVDGRFIPVYTDIKKCSNGHQFTEELGGNTVECPRCKMDNKQSHVIRKLDVIKALRELAEEVDVVFIGTDPDAEGEKIAWDLRVLLEPYANEVRRIEFHEVTRKAILNALREPRDFDIRLVESQIVRRIDDRWLGFSLSEKVQKYAWMDYCLRYLFHKRGLVEKSTCCRPNGNMSAGRVQTPVLGYIIEETDARSRPERYVYRMKIYIERIGDLVEVSIPYIDAKNAGIVDTVKKRPHPVEVEVVSEEEVQLNPPPPFTTDSLLEEASRTLGLPATRTMEIAQDLFETGLITYHRTDSTRVSDTGVKIARQYLEDKYGEKAPHYFKPRTWGEGGAHEAIRPTRPIDSDRLVELVKEGVLSLPLRLTRDHVRLYDLVFRRFIASQMEAAKLRKLVLRVYIGDRSYETEIYTEAVWKGYLEVYENVRLLGRELGLKPGERVEAEIHDGNRVTPPRLRSHDVIRWMKEQGIGRPSTYAKIVQTLIDRGYVRVTGKVKALIPTERGRSVFNFLGKYYGNVVSVDTTRRLEELMEDISKNTVEYQSALEGIYREVTTAVIGNHRVNELLEKMYREKCSEEK
(1704) DNA topoisomerase [Acidianus hospitalis W1]
3
MFNLTGPSGFPVFEVEWKPLWEIDKKSYYTRKYLILLQRLCKYAKEYINACDYDIEGSVIGYMIIKNFGDLKKAKRMKFSSLTKEELIKSFNNLQPLDYNMVNAGIARHIVDWLWGINVSRALMNAVKDTSKKSVILSAGRVQSPTLIEVVKRHLDRETFVPLPYFKIELKIRLGNIINTVYLDQEFHNIDDVESLITRLKKDKLIVDKNILNKDKIIRPPPFNLGDLQLEAGRLFGLSPYRTERVGEELYLDGVISYPRTNSQKIPPTININEIVTGLSQRFGKLVDELNLMTKGKFIVRQGNKDDPAHPAIYPTGVIPKKLGKQESEVYELIVRRFLASISRDAEVTRQRIILEFEKEKLKLQLDFQKITYEGWLKIYPYHRFENEELVNVNEGSEVEIISIKPKLLLAKPSTRFTRVSLLKWMEDVKIGTEATRGKIIETLFQRKYVVTKRSYIYPTKLGIIVSEVLEKYFNELTDVKMTADMEDKLDEIIYGKKNKDEVINEVKDKISKYFEKYNEEKKIIGLELAKGLNLVAYNKCKLCDFEAMKDGLCKYHLIAKEKLDEAIKIWEDRTGYDIKMILKYIKGSKSTGKLISDLLSI
(18) Reverse gyrase [Acidianus hospitalis W1]
6
MVTSVFLKACPNCGGPLEDYRALAGLPCSKCLPGDISPFKNLSIDEKIRLIYNILVHENKLKGYWNLYYYHQLSQEIIDYFKKITGKEPWSLQKLWLRRLVEGSSFSMSAPTGMGKTTTIIVYSTYLQNSNKNVLYIVPTKSLMQQICEKMEKIGDKTSCGKVGSGISIVTVNYINRNFEEIKEYRPDFVAVDDADAIVKSGKTVDRLVTLMGIPQEVYEDAIKLVKLKRLLAIEEKRDEIETKIAEIESRISKYYGTASQLVVASATLRPKGIKQKALKYITGFDVSTAQIYARNIIDAFTSSSVVDIVNKLGSGGLILVSKEYGKDKIKEVNESLKELGFKTAIALSGRKFLEKFSSGEIDIIIGSASYYGVAVRGIDEPKRLKYVIFYGVPKSRVRLSQAIYNPYTLLKISKLFNVNIDDNLILSLSPSEAQLIKLAFLKSQKLTGKLGEIQKILEGKIDEVKSALKAVSNEVISDTFLIRKIGKEFYIEYPDAITYLQGSGRSSRLLNGGLTLGLAITIIDDFKLYEMLKRKLQYMIYNFNPTNFDSLDIGKVKNEIERSRNDKNEELHISTGLMIVESPTKARTIAKMFGAPARRNIAGVPIYETVIVDGNNVHILDIVATKGHVADLTTENIGYYGVEIRNEDKYPYYSPLYRCMNCKRVFSQEIDKCPYCGSTLISSSMSTINAIRKIAMEVEKVYIATDPDVEGEKIAFDVAANISAYNPNIYRVKYHEVTKKGILEALANPMNIDLNLVKSQIVRRIEDRWVGFELSKLLQIKFSNRNFGAGRVQTPVLGWITKRTEEYRKNMCYVASIKLGNYTHKVFLDNKNVKIDKVIVKKMEDKDDIILPLPPYTTDSLLIDAYNLYKLPAERVMKIAQELFESGLITYHRTDSIHVSNKGIEIAKEYLDKKGLIKSFIPRSWGNEGTHEAIRPTRPIDAEELKKEIEDNPQAYFIKFTWAHFAIYDMIFKRFLASQMKEAIGKYTKYQIKVLDNVSEITVLTSIKGGFSDVLKPRIYEIPEGEIQVNPIITKGSKVRLYTYAEVIKEMKDKNIGRPSTYAKIIQTLMRHGYIVESKKKYALIATKKGINVYNYLNSKFSSLVSESTTAELLEKMDMIAGGKLNADNVLTEILGQIKSLVTSLNSEQQI
(1812) Reverse gyrase [Acidianus hospitalis W1]
6
MSEELPNLVYMNSCPNCGGEITANRLYKGSACEKCVKEDIQFNSVYDLALYLLKNKNLVNLRSSYEILKELKEVERLFKRVLGSPPLGPQRSWIVRALRGESFAIIAPPGLGKTTFGILMSLYFAEKQRKTLMIFPTKTLVNQVVQRIQEMSKSLEEVPKLAYYYSGITQSQKGELNKILESGDFDIFISTSRYIINNVDYISTKDYKYLFVDDVDSVLKSSKSASAVLKLVGFTEDDIQNVRELLRKSKNSEEVYDEIRKIREKKTGDKIAIFSSATITKGNPVFSALMGFRPGSAVIYLRNVIDSYVQLPSATDEEIIDIVNKIVNKLGSGGLIFVPIDKGVSFANEIASNISGLKAEAISSTSITKLDKFEKGEIDVLVGVATHYGILVRGIDIPWRIRYAIFAGIPRFRFKIGETMHPLAMLKMLTLISLVSKDEEVTKILRIVRNKLRRISPAALVMLANSVKSGKIEDKYIQEAYDLTNKYLRNEEILEKIAEIGEISINNRYISSPDYLTYIQASGRTSRIFGGELTTGLSVLLVDNPRLFELLNRRLSIVLDEVSWNPFDIDNNKIGNNNLHEILKRIDSEREKIRKIKKEGLLTSASVKNIKTVLFIVESPNKAKTISNFFSKPSIRVFNGAIIYETVIGDKVLMVTASGGHVYDLTTKNIGIHGIEVRKNSNLEFIPYYNTIKRCNNGHQFTEYAEGNKCPTCGSTIIKDKIDVINSFRQLALEADEILIGTDPDVEGEKISWDLYLALRPYNPNIKRAEFHEVTRRAIVEAINNSRQFSIPLLQSQVVRRVEDRWIGFSLSTKLQTVFWPQYCSEVLKRTDCGENKNLSAGRVQTPVLGWVINRYNKYNETKRTVFVVKFLNSLSVLVPKQADLDKNDVKVIVYNISKSSETFGPMPPYTTDEMLSDASNLYGISAPEAMRVAQDLFEMGLITYHRTDSTRISNTGIAVAENYLKEILEDKYKEIFKPRTWGEGGAHEAIRPTRPLDENQLRALIEEGELELPKRLTLNHYRIYGLIFSRFISSQIVPLNVDKLKFNIKVLSNGKELKVENPEMDLITNVSLPGGIEVSKLSLYYPRSYFASRDSSYSDTIKKLEECIKSGQCEFTGSIASSFVKSDYQLYTQGELITEMKNKKIGRPSTYATIIATLLKRGYMLESKKVKRLVPSKLGINVYNFLTSKYSKFVSEERTRQLLELMDLIEDGKEDYRQVLKQLYDEIQSIG
(510) Reverse gyrase [Pyrobaculum sp. 1860]
6
MDIPLVVYLHSCPNCGGPITSDRLALGLPCRECLPEGSKAASIREVVAALRRRRALRGLAWVDAYLRSYEEFSAFFKEVVGFEMWGAQRLWARRLVRGKSFAIMAPTGSGKTTFILVATLYLAGGGRRALLIFPTSALAHQAHKKLTAFAERAGRRVKALAYHSLLTEQERREVLEALERGDFDVLVTTSAFLPRRFDLLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDSVLNAALEVINLAKQMRKAEVAGDLKEVERLDQQIASLRARLREEVGKLKLGVFVASGALAKARRTVRLLLFREILGFDVGGRAEGLRNVVDLYAEAGGDLAGQVVELLKRLGPGGIVYVQDRELGETIAERAREAGIAVETFFRPRRGVLERFERGELAALVGLASSRSALVRGIDLPHVIRYVVFAGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLSGDLRYRADRLIGQLKRLAPYTLSVQEALRKAAEGGELSSFDRHSVEVVKSAVEFVGDLLRREEIRRTVETSTEVKLAYINGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVLVDDAKVFHALRRELKLRFDEAEFRRLDEVDLGKVLEEVDRDRRAIRDIIEGRAAPAATGVELMKTILMIVESPTKARTIANFFGRPSLIIADGVPIYEVSTGDAVLMVTASLGHIYELPTSLARIEQRQREVLAKWFGDFKHDGYNGEDYAVIVTKSGFVPVYNKIWRCRGGVYVDDVDIPQNCKPLDVLESIRNIAVEVDTVLIGTDPDSEGEKIAFDLYMGLRPYVSDIRRIEFHEVTRRAILNALASPRGVSFPLVKGQIVRRVEDRWIGFGLSKVLQERFGNPNLSAGRVQTPVLGWVVKTYEESLRNRMYNVDLQLDDVDLRLQIPRDVLDVLRKKKRLAVKLLGRESRVVNPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGVAIAREYIVKKFGEGAFKPRTWGEEGEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQPTRSHYQLYDLVFRRFVASQMEPSVARVAKYELEVDGHVLTLERVVDIERQGFQVVYQVTPVEPELPTGTIDVVVKRYRVIRRVLSQADVLALMRQRGIGRPSTYARILQVLAKRYYVYVTGRSKIMVPTKRGIEVYHYLENTFSKLVDEERTRLIEQLMDAIEAGKAVYEEVLQELYNEFKINVLPSLSKT
(215) DNA topoisomerase (TopA) [Pyrobaculum sp. 1860]
3
MILIVAEKRSVAQAIAKYLGRSYRVQRIHGVPVYSFSYGGREAAALGLSGHIMDFDFAARQNVWTWLPPEELFNATPLLVVRREALDYVKALRALAAKADEVYLALDADVEGEAIAYEAALVVRSVNKRAPIRRVLFNAVTPREITAAFQRPTKLDLKKVEKVFTRMQIDLTLGAAFTRFLTLAVREHLERGRFLSYGPCQTPVLGMVVTRELQRRNFKPEKYYILKALVEVEGHRIEMSSDVRYKSREEGERAAASVKHGVVKTALYKPHEVEPPEPLETVELERRASRWLGINAKKTLDIAEELYRAGYISYPRTETTIYPQTLDLREILRDLAETEHGPYAEELLRRSFKPTRGDSDDGAHPPIYPTKGATKAEIMKIFGKAGAQAWAIYDFVVRHFLATLSPPALVEKQKIAAAFGGVEMYAEGQRVISEGYWRIYPWERQRDKPLPRVSPGAPARAIKVEVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIHTNVKRGYMKLAKGRCVPTDLGIALATALFQHAPELIEPTVRAKIEAALNSIVRNSTPPPKLIAEVKAEFRTYYENLKARREEIKKALLNALNTHRQ
(539) DNA topoisomerase [Sulfolobus solfataricus P2]
3
MNLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVSYWIIKDHNSSKYVIVPAAGHLFGLKGESGFPVYDADWKPLWEIDKNSYYTKRYYQLISSLSKYALGFINACDYDIEGSVIGYLIIKNLGDIKKAKRMKFSALTKSDILSAFRNISALDYDMINAGIARHKIDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVNSEIERNLFIPLPKFTVSIIVKIKDYSLNIKVNKEFEKITEAKEFLNKLINKTVKVVEVENRVRLLERPSPFNLTDLQIEAGRIYGISPYNVERIAEDLYLDGLISYPRTNSQKIPSTISIYNIIKGLENSSYRKLVDLVRKITGGKYVVKQGIKDDPAHPAIHPTGEAPKNLPNSKFKIYDLIARRFLGSVSADAKLSNTIYTLKVSDFPLEFTVSYTKILERNWLDIYHFHNVKEDKPIFLSKGDEGKIVDGKVNISLSKPTSRYTKVSLLKWMESSNLGTEATRGRIIEILVKRKYLTNNGRYIIPTKLGFYIAEILNKFFPDIVDVRMTADMESKLEMIKTGKVLESKVIKENIEKLNKFIEEYKVNKDKVGESLAKALGLIKIVKCKYCDLEQYKDGLCKYHYEAKVRLLDAVEIWKERTKYDHKKILKRISSSKSTGKYVKDIVTYMLSSE
(7) Reverse gyrase 2 [Sulfolobus solfataricus P2]
6
MINVMYKNSCPNCGGDISGDRLLNGLPCEACLPYINGIDDVDHISKVKTLYNILLNNDKIKNYWNLYYNITTFETVFKYFRDKTGYEPWSLQKLWLRRLASNQSFTMSAPTGLGKTTTLMTYSVFIGQDVVYIVPTKSLMEQVCKRLEKLGAQVSCGKIDQKKVSVITISYLNKNADSIVSLKPNFVVIDDADAVIKSGKTTDRLVSLLGIPKDVYESAIQLIRLRNKYYFSNEYTEEVKEKIRELELKIAEFKDKISQLVIASATIRPKGIKQKALRLLTGFEPSSIQLYARNIIDAYTENLDLSIVKELGSGGLILVSKEYGRSKLNEIKKYVEDLGFNAKLAISGRKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIRAKLFDALSNPFTLLRVGKLIGIDFSKLQNKILILNPSEVQLLKFSIIKGESINYHKLEQLRQELLYYMSLVKDKLKEKVEDTLISDSFVITKQNGNYYIVYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDRHIFEILEKKMQKLFPNTTFTSLSNTNLSEIKIKLEDSRKEEGNRVHFNISTGLLIVESPTKAKTIAKMFSRPSVRIRNKVPVYETIIVDGNQIYVLDIVASKGHIVDLTLEDIGYYGIKVEDDGTIKPYYDLIKKCLDCNKIFSSASDKCPYCGSANLQSAQTTINLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVYRVVYHEITKKAILEALRNPKKINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVNKTIKYKSAMGHVVYIDIAGYSIKKYFSEKRKVEEYINNLQVARIEKISEEKILLSPLPPFTTDTLLIEANMKYKLPANLVMKIAQDLFEAGLITYHRTDSTHISSVGIEIAKEYLQKQALIKEFVPRSWESSEEGAHEAIRPTRAIDVNELIQEIEENPYKYSIRFSKLHLLIYDLIFKRFIASQMSHAVGTKSRYLIKLGKDDNVDVELLSNAEGGFIKVYPVKVYNLPVGEIQPKVNITKGSSEQLLSYSDVISLMKSKGIGRPSTYAKTIENLMKHGYIVSSKRKSYLIATNRGISVYQFLSSKFYDLVSESTTSRLMTKLDDIALSKLNASTVLLEIFSEISTLVNPLKSEQNV
(334) Reverse gyrase [Sulfolobus acidocaldarius N8]
6
MLKVNYLFGCPNCNGSISVDRLHAGIPCETCLPGAVEKLDIRTIYDLLVKYSTLKGYSELYMDLEMYDDILRLFKKIVGGEPWSLQRYWLNKLVRGESFSLSAPTGVGKTTTLIVYSVYSHTTSLFVVPTKSLRDQICEKLKKIGHLVSCNKPEEDKVNVVTFHSINKNIDEFVRIKPKLLMVDDADMILKSGKTTERIAKVLQIPQEVFDDTIKMLRLKRMLRFKEDEDLINQVRELESKILGYKSSVQFIVSSATLKPKGYKQMALRFLVGFEPSTIQIYNRNVIDSFTYSNNVNELVKEIGDVGGLILVSKDYGKKYVDQITDNLNAEGYRAMKAISGRKFLEKFSNGDVDFLVGSASYYGVAVRGIDEPKRLKYVIFYGVPKTKLPLEDSLNNPLTALKIGELLKLDVTEYRKRLIYLSPAELQAVKIALRNKVSLNGKLGDLVEDLTKLKDIILDTIKANKIDKLVSDSFVIKKDTNKHYIFFPDIITYIQGSGRSSRIMNGGLTLGLSVVLVDDLELFDILNKKLRRIAEVTFMNFDELKLDEVREKLNKSRSDGSGGRSMNFKTALLVVESPTKARTISKIFGRGVRREIYGIPVYETIIIDDHSNTIIYTNIIASKGHLTDLTTEELGYYGVEINDKDIVVNYSPLYRCMSCGKTITKKVSTCPYCGSSMINSSEKIVNAIRLISTEVDEVYIATDPDQEGEKIAYDIYSLISPYNQNIFRISYNEITKTAVLNAIKSKAKINESLVKAQIARRIEDRWIGFELSSVLRSALNDNNNGTGRVQGPVLKWVVGKTSEYKANIGYVVDINIGDYVVRKFFKTKKDAETFISQLNVKVTKIAERTSTIDPLPPFTTDSLLIDAYSKFRINSSLAMKVAQELFEAGLITYHRTDSIHISPYGISIAREYLEKIGSNDFVGRSWGNEGAHEAIRPTRSMDVEELRKEIEENPFQFGIKFTWAHYRLYDLIFRRFIGSQMSSATATYTTYEININGELYTVELPTKVHGGFSSIYGIRVYNLDESHLTTRIRKGSLVSLLTYADVIRLMKDTNIGRPSTYVRTVQSLIRHGYVVESKKRSFLIATNKGQKVYEILNKYFSDMVSESRTSHLITKIDKINRNELSAEDVIMDLLNEIKNIKLVNPLQSEQYV
(1873) DNA topoisomerase 1 [Candidatus Korarchaeum cryptofilum OPF8]
3
MTTLILTEKPNVAKRIASILSEGAKAKREGKVYYYEFDTGGERYYVAPAAGHLLELDYPPGKWEYPSIVPPERLVLKEIKGKREYLKILEKLGKLSNRIIVATDLDSEGSSIALEIIKALNWEGKEILRMEFSSLTKEEIRSSFRDLKPFDYPRAYAGWVRRVIDLEWGANVSRGLTLSTRRKGWVRVLSSGRVQGPTLSMIVKREREIREFVPKKYYTVIVKVDKGFSLELAPPKGEERIWDQDYARRAAESVKDTLIARVKSDERKLSPPPPFDGTSLQVEVSAITGLTPRQIADRTSGIAQKLYEAGLISYIGTESQKYPKSWKKKDFVDMVKLIASYSPLKEEAEFVLGDMREAAVEGKKDDPAHPTIHVVGVPEERLEGKYREVYEIIARRNLATLAQDALIKRIRVESNVDGFIFRASGLSVLREGWLRVYPYARMEEFPEVEDSEELRVVEVKIEEKETQPPKRYSHISLIKEMERLGLGTKNTRVQIIDILKSRGYLEEGSFKPTRLGEAIVEVLESFVPALTNPELTAKLERGMNEIELGKLDPSNFLKESLDELSAIMDEFKRNELKISERLYEGLREYRSGSLGKCPECGGDLNMRKSSYGYFIVCSNYPEKCDVKFNLFKNERFEGKFCECGLPLVSGRIKTKSNRGRGYTRCIANCDRTPLRCAKCGGPMVAKQGKFGVYLKCENCGSTNFFRVRKH
(954) Reverse gyrase [Candidatus Korarchaeum cryptofilum OPF8]
6
MIPAAFLGLCPGSEIFKTHERSSCLEEDLRAISEELKDYKKFFESCIGSPPWEAQLMWAKRALARRSFAAIAPTGVGKTVFGLITGSYFAHKGFGKSYMLFPTSLLVDQAHYNLLNYSKCSGKQIRVISYRSGMKGKEEFLSALESGDFDILLTTSQYLSANHELIRKSVNKFSFIFVDDVDSFLKNSKNVDKVLQLMGFDQEDIWNAMRGREVEKRTDSVLVVSTATGRPGQRASLFRSLLGFEVGIMRPELLRNIADIYTRERSELNSFMRRMGSGFLLFLANMDLADEALELVESAGFRGEVMHGYEEDKVRDFSEGRLDCLIGASKPYGVLVRGIDLPKRIRYVIFYGAPRFEITLREVSEMEDPSIISLFSSLSRALGSEERKLAMKLRRNPSKEDIGRARQIIEDILKDEEKISSISSLADVIIDVRGRRILIPDIRTYLQGSGRTSRLYPGGITRGASLVWDEDPVLTSFIKKARAQEIDFLHLREVDLEKLRSEIDESRRIISSLKKGYELANLLKTALFIVESPSKARTIASFFGRPSRRFLDGLMAYEVTTGDYVLTIVASGGHIVDLTTTMGYHGVLIEDGTYVPAYTSIKRCNSCGHQFTDMDRCPRCGSTDLRDSRSVVESLRRLSFEASRVIIGTDPDTEGEKIAWDIYQLIMDSSGEIYRAEFHEVTKRAIIEALKSLRGINERMVEAQIVRRVEDRWIGFELSAEVQKRFGKRNLSAGRAQTPVLGWVIDRYREHQNKKVVSIIKGDGLLLRVDGRVGEEGASKIWIRELKIEEEVVKPPPPFTTDAMIGEANRVLRMSANMTMQLAQFLFETGLITYHRTDSPRVSDAGFRVASLVLGEDFVPRKWGEGGAHECIRPTKPLSAKELIDYVKEGIIAVEGLSKDHIRLYDLIFRRFIASQSRDGTLVKQVASVRVGESEFEVTRLVEARGGWIDWYPFLHITEPRLKEGMVDVIIEHQTVPSVPLYTQSNLVALMKERGIGRPSTYATIVEKILQRGYVIERNQKLIPTKLGIEVYNFLRDRFPDLISEERTRTLERKMDSIEEGAADYQELIDELYKEIREKIGKFIH
(913) NEQ324 [Nanoarchaeum equitans Kin4-M]
3
MDWLKLYKEFYKFEDNPFKEGQTIEGQAKIIKEKTKPPARYNEATLLKKMESLNLGTKSTRALIIDILFKRNYVKGKSIYITPLGEKVIEVFEKYLPQIIDVELTRKMEEYLEKIEKGHLEYREKAIEEAKQIIKEVTKEIKEKEKEIGKELYDVYLKARNSQDSRSRKRGT
(1769) DNA topoisomerase [Nanoarchaeum equitans Kin4-M]
3
MIIIAEKPSVAKRITFSLTTNYKLISKNPPQYYFKIDSKPVIVIPAAGHIYNLDTNQRGYPVFDYFWNVEKGKTKFAKAFSKYKNEKEVIVATDYDLEGELIGYNILRFALNKTNAKRMVFSALTPKDLREAFFNLRESIDKNLAIAGETRHIIDWLYGINLSRALTYALRHYVKDVTLSIGRVQGPTLRLVYEREKEISNFIPEEYYRVVFIHKNYKFYYIEKLKNLERAKEIAKCKELKIVRVKEEKVYLPPPHPYNLSAIQQDAYKFYKISPKDTLLILQKLYTNGYISYPRTSSNILPESLDYRYILEKLKLWGYSYYISYLLKKPILKPNNGNIEDAHPAIYPTGIIPKGLSKKESLIYDLIVRNFIATFMDKALIIKFKVYGRCDKYLFVYEGQSYGNSSGK
(1180) NEQ434 [Nanoarchaeum equitans Kin4-M]
6
MKIYYNNVCPNCSGRISNERLIKGLPCENDYPYEEGTIEQVYEYLKENNKLKDWANIYNIEKAKKEFEEFFYKAVNNKPWSAQRAWFIRAYKGYSFSIIAPTGMGKTTFALVNALYWGKKGKKVYIIVPTRTLVKQLYEKINVFAERVGFDNIIVAYYGNNKQKKEAKELIKDGAFSILITSNQFLSRNFDLLKNNYFDIIFADDVDSIMKSSKNIDRILYLLGFSETTIEKAMQLIKLKISGKDLEKIRKMEEQLKELVRKEQRGILIAASATGSMRGLRVKLFRELLGFEVGAAKTTIRNIIDVYTEMRDYKKQTLELIKKLGNGGLVFVPTDYGIEKAEEIAQYLKENNIKAEAFYSGKSIELLDKYANKELDVLVGVAHYYGLIVRGIDLPHVVKYAIFVGIPRFRFSAKEKETKIGRILLLASTLSDYADEEFKKKLNTTYNMIKRVSTGALKMVEEAIEQNKELDGFLEELRKNIIYLRDKSFELINREDIIKKLEENPFIALERGDGINILIPDVKTYIQASGRTSRMYPGGITKGLSIILSDNEKLLRALEFKLKLLGIDLHPGSSS
(1248) Reverse gyrase [Nanoarchaeum equitans Kin4-M]
6
MLRLEEIDLDTIKKELDEERKKVEEIMKGNIPTEIKDLIKMVLFIVESPNKARTIANFFGKPSVRRIGNIKAYETTTGKYILTIVATKGHLFELTLKEEGVYGVLKEKEYVPIFSPIKKCLDCGHQFVDEDKCPRCGSENIDDASDRIKVLRDLAQEADIVLIGTDPDAEGEKIAYDVYSIIRPYNKNIYRAEFHEVTRQAIIKALEEIRDINTNRVKAQLVRRIEDRWIGFALSQRLWSRFKKKTLSAGRVQTPVLGFIIKRYEEYKKNRAHYYAVKTSDFEVTFISDDPLEKYDKTIKIEKIEEKESEKKPLPPYTTDSLLRDAVIELRLSVDKIMALAQNLFEWGLITYHRTDSTHISNLGIQIAQTYIENTFGKEYFYPRHWGEEGTHEAIRPTKPIDTETLIKMLREGDIQIQGITKEHIRLYDLIFRRFIASQMKPFIAIETKFNAVWSNLNTTIEGITDIKENGWNLIKPIKLLAIKEGEYEVIDVKHWIGSKVPLYTQADVIELMKEQNIGRPSTYATIVKKLFERYYVIEKNQRLIPTERGIKVYQYLTERFGHLVDVKLTADLLEKMDRIENGELDYMDVLRSFKKELIEIWKTKETKYIADGIYKWKEYSVPAIVYERYEKILKRKKVYPEYLTPWSRAIYNALPLDNEIEKQTLALAIEKDFEILTKKPILREYKKKYEHLKNLVDQLL
(270) Reverse gyrase [Pyrococcus sp. NA2]
6
MKAIYRGMCPNCGGAITDERLSSKNPCEGCLAEPIVLQDYDKLIEAIRNALKLRDTLKDWEELYRLNKEVSEVEELFERATGFRFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYFATKGKKSYIVVPTTPLVIQTVKKIKAMLERAKLNVNLVYYHGNLKKKEKEEALEKIRNGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLMLGFSEEMINKAWEIIKLKKQLAKLLQNEGKEEEVEKLNREIEKAEREIEAYKKNNNIGILIVASATGTARGDRIKLYRELLGFEVGSGRSVLRNIVDTYLIPEKSIEEHVEELLRKLGKGGLIFVPIDRGIEYAEKLTEYLKKKGFRVELVSAKSKKGIELFENEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEDKRAEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKSAVEFLRAVLKDEEVIKRIAENPFLSLKEIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVVIVDDEKVFNGLLRQMRWRFVEFEMKRFDEVDIDDVLREIDEDRKKVRMVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRKIGDLVAYEVSIGDRMLTILASGGHMFDLVTTEGYHGVLMLKRNGKPYFVPIYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIREARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLVLENGISITIENAKGNVSEVTVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSTHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPVDTGRLIQLIRDGIITLPRNLTRDHFRLYDLIFRRFIASQMKPAKVIYEEAIISTPFGDVEVEGYIDVIYDGWSRIKPLPLKKIPKLEKGQVIKVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLMSKYKPLVNEERTRQLEKIMDMVEEAKADYQDVLNELYDEIKAYVK
(1147) DNA topoisomerase 1 [Pyrococcus sp. NA2]
3
MILVIAEKPNVARKIAGALAEGRPIKRTMFGVPFYELFRDGKKVIVAPAVGHLYGLAPKQDFYGYPIFEIEWVPVYMAEKGKEYAKDYINLLSVLSRRVREFIVACDYDTEGEVIGYTALKYACKVDPKIAKRMKFSTLTKGDLIRAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWIILSTGRVQGPTLKFLVDREREIQSFVPKPYWVIKMVIEKGGKKLVATYEKDKVFDEAEAKRIVEETRKGKAIVEKVEVKRQNRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQSLYEKGYCLHPDSLILTPSGIKKIRELPEKGEVLALDFNLKLSKAKYRLLERDADEPMYRIILSDGTELYLTGDHPVLTYREGRLIFIPAEKLKENDKVVLLNGGYKDTYSLSFLLEEASMDDYIIYEKSFGEVIKTRMTNEMKEIYSYLNGKIPIPVLRFLIEKKIVSEEEIFKVFRGFSYLDSQLPINDRFWHLIGMIIAIGYKLENDNVILLPSKEITNRVIEHVEALGIPFVYDGERLVLKSKSLSRLLKIIGDKVIPPKKDWMISLIKGYQEVNGLRFRDKELAYKLKVMFQLLGVRTRLKRGTTYELVIDSEHEPEVEEGPDAPRVANGDVYILEIKSIDKFHYRGKVYDLVVEDYHNFIANGVIVHNCSYPRTSSQKLPKNLNFRFIIQNIARMPEYRPIAHELLGKEVLKPVEGKKEDPAHPAIYPTGEIPEPGELTRDEWNLYDLIVRRFLALFMEPAVRESMKVIINANGHRYILSGARTVKEGWLRAYGKYIKFDEVILPLFFRGERVRVLQVRRERKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVVETLEKYVPEIVSVELTREFEEKMELIMQGKLTKEEVIEEAKERLTKILQKFKEKELEIGIELAKIVVGEDVKLPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQKGEIIPTNKTCCNGAPVVIIREEDGREIEICLDMNCKWPKSY
(199) DNA topoisomerase 1 [Pyrococcus yayanosii CH1]
3
MILIIAEKPNVARKIASALAEGRPVKKSIYGVPYYELTRDGKRLIVAPAVGHLYGLAPKRDFFGYPIFDIEWVPVYVAEKGKEYAKDYIKALSVLAKRAKEFVVATDYDTEGEVIGYTALKYACGVDPRKAKRMKFSALTKRDLLKAWYNLEPTINFGMAGAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQNFVPKPYWIIKLILEKNGRKLTATYEKDKVWDEEEAKRIVQEARKGYAIVENIDVRRLQRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQSLYEKGYCLHPDSLIPTPDGIKKIAELPKEGEVLALDFNLKLSRARYRLLERDADELMYKVTLGDRTELYLTADHPVLVCRDDKLIFVPAEELKESDQVVLVIAREGFKGRENPPTLLDFLLENARTMKDYILYDPEFGKDLRRRLKERGLKVEVMAEFNIRESTYYNYLRGKMPVPIAKFLLDKGVISREELRSVFRGFAYSTSLSPISFEFSEEFWYLYGFVVGSSYTVKNGALVISAKEREEDIVRAIREVANSLGVPFRYDAKYKLIIIRSKSLTRLFELLGCSYGNKTRTFRIQGIVVSRPGWIAAFLAGYCDADAHIRVKPTGSRKSLSPQIVLTSKNKEVIYTIKLMWQLLGVRTYLLEKKDKNGVVYELKVYPKDVPRFYEVLRSFLIVKRKDLERVIEIVAGKRAINIEETAIPLTDEDLRRIATGDVYLLKVNGIEKFRYRGKVYDLVVEDYHNFIANGVVVHNCSYPRTSSQKLPKNLNFGAILQGLSKLPEYRPFAHMLLGKEVLKPVEGKKEDPAHPAIYPTGEVPKPGELTKDEQNLYDLIVRRFLALFMEPAVRESVKVTIKAGSHRFILSGARTVKEGWLRVYGKYVKFDEVLLPGFRRGEPVRVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVVETLEKHVPEIVSVELTREFEEKMELIMNGKLTKEAVIEEAKERLLKILEEFKRKELEIGRELAKIVIGEDLVEDKREDIVVVGKCPKCGGDLVVKYNRKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCDGTPIVIIREEDGREYEICLDIRCRKGKGR
(403) Reverse gyrase [Pyrococcus yayanosii CH1]
6
MKAIYRGMCPNCEGRISDERLSMKNPCESCLDEPVGEQVYFDLIKAVRDALKLKGTLKEWEEIYKLNKAVKDVEKFFEKATGFTFWSAQKTWVKRLVRGRSFSIIAPTGMGKSTFGAFMAIYFAQKGKKSYIVVPTTPLVIQTVRKIRTMAERAGVEVNLAYYHGNLKKKEKEDMLAKIRDGNFEILVTSSQFLATRFDELLKDKKFDFIFVDDVDAFLKASKNIDRSLILLGFTEDVIAKAWEIIKLKKQLAKLLQRGNIEDIERLNSQIERLEEEIEAFRQKNNVGVLIVASATGSARGDRIKLYRELLGFEVGSGKSVLRNVVDSYLIPEKPVEDVVAELLQKLGKGGLIFVPIDKGIEYAEKLTEFLKERGFRVELVSARSKKGLELFERGEVDHLVGVATYYGTIVRGLDLPHLIRFALFTGIPKFRFSLDLEQPTIYRVLGLMSEIIEFLPEEDRRTGEKLYSRLRKIIRNVPQFELMKIEEALAEGLPLEGFQNHVLEIFREAVEFLRRVLKNEIVLKKIAEDPFLSLKREGDKWFIEIPDVRTYIQASGRTSRLFAGGITKGLSVLIVDDEKVFNGLVRQMRWRFTEFKMIPFEELDLEEVLKEIDEDREKVKLVMEGKISAKVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGDLVAYEVSIGDRMLTILASGGHMFDLVTNEGYHGVLIQKKEGRPFFIPVYDTIKRCRDCGHQFVDWEEKGACPRCGSKNVHDALENVKAMREIAQEVDEILIGTDPDTEGEKIAWDIRNVLAPYAPVIKRIEFHEVTRPAILKALREARDVNENRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWVIQRYKEFTESETDFLNITLENGLSITLEGAKGKVGEVIVEDVQVEERDVNPLPPYTTDTMLQDASRILGFSAPYAMQLAQDLFEAGLTSYHRTDSIHVSNTGIEIAKEYITQEIGEGYFQPRPWGQEGAHEAIRPTRPIDTGRLIQLIRDGIITLPKNLTRDHFRLYDLIFRRFIASQMKAARVLYEKAIINAGLGKAEVEGYLEVLFDGWSRIKPLPLKQLPKLEPGQRIKVKELKHWRAPKVSLYTQGDLIALMKERRIGRPSTYAKIVQTLLQRGYVVETKGRKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEELMDMVEEARADYQEVLNDLYKEIQTYVR
(432) Reverse gyrase [Pyrococcus abyssi GE5]
6
MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIRS
(176) DNA topoisomerase 1 [Pyrococcus abyssi GE5]
3
MILVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDFFGYPIFDIEWVPVYIAEKNKDYAKDYIKALSVLAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPKPYWVIKLVIEKNGQKLVANYEKDKIWSEEEAKKIVTEVKKSKARVSNIEVKRQKRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTESQKLPKNLNFRLIIQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPGPGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPHKFMLSGARTVKQGWLSVYGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFERKMDLIMQGKLTKEEVIEEAKVKLTKILEEFKKRELEIGLELARIVVGDVKDEIKEEKPIVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIRDKGRDIEICLDIKCKKW
(431) Reverse gyrase [Pyrococcus abyssi GE5]
6
MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIRS
(175) DNA topoisomerase 1 [Pyrococcus abyssi GE5]
3
MILVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDFFGYPIFDIEWVPVYIAEKNKDYAKDYIKALSVLAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPKPYWVIKLVIEKNGQKLVANYEKDKIWSEEEAKKIVTEVKKSKARVSNIEVKRQKRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTESQKLPKNLNFRLIIQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPGPGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPHKFMLSGARTVKQGWLSVYGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFERKMDLIMQGKLTKEEVIEEAKVKLTKILEEFKKRELEIGLELARIVVGDVKDEIKEEKPIVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIRDKGRDIEICLDIKCKKW
(1006) Reverse gyrase [Methanocaldococcus vulcanius M7]
6
MIPMIYKGMCPNCEDEIRSERLEVGVCEKCLPIDKKLEKLELCKNLKKEKTLKNLEKYCSVWNEFKKFEEFVKRLGFELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGIIMSLYLTKKGKKCYIILPTTLLVKQTHDRILSLIEKCKLNINVISYHSDLSTKEKKEAKEKIENGDYDLLITTSNYLAKNDINNKFDFIFVDDVDSLLKASKNIDKTLKLLGFDEELIKEAYKIIYLIKIGKIEEALKKREELKRKVSNINHGCLIIASATGKSYGDKVKLYRELLDFEIGFGMNKLRDVEDIYDEEFKKEEVLEYIKIFGSGGLVFVPIDYGVEKAEEIEKYLLENNIKAKLIYSKDKKGFEEFRKGEIDVLIGVASYYGVLVRGLDMPERVRYAVFYGIPKFKIKLKEYIDKLIEKGVLKENIDIENKSEDEIRHIVKEKLKMKNFSIKLENGEYFILIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDDKDIFEYLRKYMLFMYESEFKKIDEVDIRELIKKIDEDREKIKSGRSSGKTPDLLKSVLMVVESPNKARTIANFFGKPSVRKIKNRNVYEVCVGDLNLLITASGGHVFDLVTKEGFYGVKIEDNIYIPIYASIKKVNGEQFTDQKDLEDVIKQLMEKGEKITNIIDAKDNIEIIREIADEVDALFIATDIDTEGEKIGYDIALNALPFNSEIYRVGFNEITKRAILRAVESFKKGEELSLDENKVKGQIVRRIEDRWIGFRLSQKLWEVFNKNYLSAGRVQTPVLGWIIERYNEHKIKVPYLSLKLEGDIYIGKIWEGEFDKEEVSVETTTYEKELPPMPPFTTDTLLEEATKRYHIGTDEIMSIAQDLFELGLCLTPDTHIVLGDGRIKTIEEIVKSREKKEILSLDLDRKSIICDKIISFWEIKFSGNLKKITLQNNYEIKATPDHHILTLKDGRLKWIPAKNIKEGDYVVMPFNYNYKIRRSHPPSKIFEKIKKIVEIDNFNDVREPEFWYNLGLLFGNDRLSLQGSEKEHLVEELFSLKEDYINAFIAGYLDARGTFLKRGKEINIATFSKNKSILEKIGIYLHSIGILTMIQEHNGYFLVIDNKFLTTFTEKIVKYTKTKNLKEFCRTVIENKNKNKNVKKSNKKIKVGNIYNDVIFIKVKKVEDLFYDGYVYDLSIKCNENFISNGIISHNCTYHRTSSTRVSIDGMKVAREYLKLNNLEHYIKNRDYFMEGAHECIRPTKPMDTDELIEFLRENNIKLTKNHIKIYDLIFRRFIASQTKEAILEYEEIYIKDLDEKIEGYVDIKFDGWSRFYPLKLKKLPKIEKNSLKVLEKKLIKVPKVPLYDEGEVIKLMKERGIGRPSTYAQIIKKLLDRKYVIKSKDKNKLIPTKLGIEVYNFLIENYPHLISEERTRDLEEIMDKIERGEVDYLEVLKVLHEEILSIE
(1862) DNA topoisomerase 1 [Methanocaldococcus vulcanius M7]
3
MTALIICEKPSVAKKIANALGKPKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVENENNEFGKYPIFDIKWVPASVDKGKEYVNKYIKALKKLSKEADEFYIATDWDIEGELIGYHALKYCCGREKAKRMRFSSLTKKEIVKAFENPDEIDYGLVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFIPKPYWVIEALLKDNLKAIHEKEKFWDEKEAKSVYEKIKDEKSAKVVEIKKTKRRIKPLPPFDLGTLQREAYSYFKISPKETQEIAQRLYERALISYPRSSSQKLPKDRKYLEDILNIIKNHPIYGKWAEKILEKNLKPVEGKKDDPAHPAIHIVDIPKEELSEKEKKIYDLIARRTLSAFWDNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDEIELPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKRGLGTKCLTAKTLIKVKIDNEIKYMEIEKLFELLNEKYKEKNIELAVNNKDIKCFSFNYKDEVESSFKFISRRKLEKDESVYRIEFEDGSFIEATEEHPILIYDNGDFRYVKANDLKKGMKTISFTDNKDFITKTISNIRKINYNGYVYDIINSEYLNFIANNIVVHNSTRAEIIDKLIKRGYVVDDGSLKVTDLGISVIETLKRFCPEIVDEKMTRDLEEKLEKIQFRKIKKDEVLDEAENKLRKILEEFKEKEEDVGTYLIKNLDATNKKAKIVGKCPKCGGDLILIRHKKSRFVGCSNYPECDVNYSLPDKGRIKIPNKVCNACKSPILKIGDREICINPECPLKQVEIKEEDRICPKCGAELILKKGVYGAFYGCSNYPKCKYTEPINKKEKEIVGKCPKCGGDLVVREGKFGKFIGCSNYPKCKYTEKLKENEKKENKKGEDKT
(1088) DNA topoisomerase 1 [Methanotorris igneus Kol 5]
3
MVALIICEKPSVAKKIAEALGKPKKKSIYGVPYYELERNGKKILVASAVGHLFTLVEKKEGKFGEYPVFDIDWVPASIEEGKKYVENYIKALKKLSKEADEFYVATDWDIEGELIGYHALYYCCGKKNAKRMRFSSLTKKEIVKAFENPDTIDFGLVDAGDSRHKVDWYFGINVSRALMEAIRAVKRWKTMSTGRVQGPALAFLVERELEIKRFVPKPYWVISALLDEKLNATHEKEKFWDEKEANQVYKKIKDVKEGIVVEVKKRKKKIKPNPPFDLGTLQREAYRIYKFSPKKTQEIAQRLYEKSLCSYPRTSSQKLPKDKKYLEDVLSIIKNHPIYGKYAERILKENLKPIEGKKEDPAHPAIHIVDIPKEKLSEEEEKIYDLIARRTLAAFWDDAEREYCNITIDIGGEKFKLSGSRTVKEGWHEIYYFTKFDEIELPPLKKNEKIKVEKINIERKETKPPKRYTVASIIKELESRKLGTKCLTPNTLIKVEIDNIIKYIKIENLFELLNDRFKDGNVEFAINNKNIKCFSYDTDEIKSIFKYISKRKLEKNESVYKIEFEDGSFIEVTEEHPILIYDGDGEFKYIRAKDLKKGMKTISSIKYDDKEGDVICTWEKFIEICNEKSKLYGISEDIGKIREKLGMSKYKFAKKYGLSCSSVWKYEKNKRIPIYLFKKLDLKKPNYIASTNKNVIIKNPFPLKISSSLVRILAHLIGDGSIDKEKIKRENCYDFRYHNTNIDLIKQFVEDIERVFGIKLTIKKAKKRKNQKLKYYVQVPSVVGRIISILFKEVIEKNAPKIPKEFYPEFIGALFDDEGCAIEKEGKAFISNTNLELLKDVKEMLLELGIKSRIDEKQFKLFIKGRKNIQKFLNIIPFISVDKKQKLINALSNKYKWKDCSVVKKEKEIIKVLGLYGAIDLNELSKKTKLPASVVREYIKEFIKNGIVEEIVSDNKKIVYTLKIPPHKTFYRYIGEKVINKDFITKTISNIKKINYNGYVYDIINSEYSNFIANNIVVHNSTRAEIIDKLISRGYVVDDGSLRVTDLGIAVIETLKKFCPEIIDEKMTRDLEEKLELIQSGKIKKEDVLKEAEEKLREILKKFKEKEKEIGKELVSKIDSTNKKLKTIGKCKCGGDLVIIRTKDKKRFVGCTNYPECNITYSLPKKGRIKVLNETCESCGLPVIGIDGQKLCINPECPSKMPKENIEDLKESINNGKKICPKCGGKLVIKNGIYGAFLGCENYPKCKYTEKIKKNNGEVVGKCPKCGGDLVKKNGKYGEFIGCSNYPKCRYTEKFKK
(962) Reverse gyrase [Methanotorris igneus Kol 5]
6
MVPIIFKNMCPNCHSDIESLRLDKGLTCKNCMEDDSVSNICKYLAEKNTLKALEDYCKLKNELKELEDVAERCGFKLLSIQRMWAKRVLKNKSFSIVAPTGVGKSVFGMITAIYFATKNKKSYIILPTTLLVKQTYEKIINMANKAGVEVNVVAYHSELSSEEKRVAKEKIEKKDYNILITTSNYLSKNPIDDKFDFVFIDDVDAFLKASKNIDKSLKLLGFSDEIIKKAYNILYLIRKKKIEDALKEREKLKEMISKINHGCMIVASATGKSYGDKVKLYRELLDFEIGYGMSKLRDVEDIYDENLSMEKILEYIKIFGDGGIIFVPIDYGLKKAEEIEEFLIKNGIKAKLIHSKDKKGFEEFKNGEIDVLIGVASYYGVLVRGLDIPERIRYCIFYGVPKFKIDLEETLKKENENISIEGLNEEELMELVKNTLKIKNFSLRKEDNKYYLLIPDVKTYIQTSGRTSRMTENGLIKGASIVLVDDAEVFEGLKKYMLFMYEGEFKRIDEIDVEKLIEKIDEDRRKLKETKEKNKVPDLLKSALMVVESPNKARTIANFFGKPSVRRINNKKVYEVCIGDWNLIITASGGHIFDLVTKEGYHGVLIGNNSYIPIYGTIKRVNGEQFVDEKNIEELIKRIKEKTNENIVIHDAKENIEILRDLASEVDAVFIATDIDVEGEKIGYDIYLNLKPFNKNIFRIGFNEITKRAIMNAIKIVKEGKSEELSLDENKVRAQVVRRIEDRWIGFELSKKLWDAFNNTYLSAGRVQTPVLGWIIDRYNEYQIKVPYLYLKLEDDISFGTIVDDETAKKIKDKDYVDVEVNVYEKDIYPNPPFTTDTLLEEATKRFGLSSDEVMKIAQELFELGLTTYHRTSSTRVSLDGMRVAREYLEFNDMLDYLKNREYYMEGAHECIRPTKPMDTSELIEFIKNNNIYLTKDHIKIYDLIFRRFIASQMKECKVEYEEITIKDLDTKVEGYTNIIYDGWTKIYNLKLRKLPKIEKNTLKIIEKSIRKVPKVSLYDEGEIIKLMKERGIGRPSTYAQIVKKLFDRKYVLKSKDKGKIIPTKLGIEVYNYLKNNYYNLICEERTRELENVMDKIEKGEVEYIKVLDELLNEIKSIT
(1741) DNA topoisomerase 1 [Halobacterium salinarum R1]
3
MELIVTEKNNAARRIADILSEGGASTTQTAGVNVYEWGGRRCIGLSGHVVGVDFPPEYNDWRDVEPAELIHADVVKDPTQEDIVNALQRLAREADDVVIATDYDREGELIGKEAYELVREVNEQAPVNRVRFSSITDTEVRSAFADPDDIDFDLAAAGEARQIVDLMWGASLTRFLSLSAGQMGEDFISVGRVQSPTLKLIVDKEREIEAFDPDDYWELFADLRKDQTTFEAQYFYEDPADGTEAERVWNEGDADAAFDALRQAGEAVVDSVSRRTRTDDPPAPFNTTQFIRAAGSLGYSAGRAMSIAEDLYTAGYITYPRTDNTVYPDDLDERDLLEAFQQTVFGDDADSLLDQDRLSPTSGDEETTDHPPIHPTTDFPDRNQLSEDEWAVYELVVRRFFATVAAPAEWAHLRVTADADGESLKANGKRLVEAGYHAVYPYYDSSENHVPPVEEGDTLAITDARLDAKQTQPPRRYGQSRLIETMESMDIGTKSTRHNTIEKLYDRGYIENDPPRPTTLAEAVVEAAEDYADVVVSEEMTSQLEADMTAIADGETTLDDVTTESREMLDRVFDELTASRAEIGDHLRTSLKADKSLGPCPECGDTLLLRQSRTGSHFVGCDGYPECQFTLPLPSTGDPLVMDAVCEDHDLHDVKMLAGRNTFVHGCPLCAAEAADESEDRLIGPCPDCGEPHGGELAIKQLQSGSRLVGCDRYPDCEYSLPLPRRGDIEVTETYCDEHALPELVVHDGEDDDPWELGCPICNYEEYQARQRQQGLEALDGVGPKTAAKLESAGVEDVGALADADPEGIADAVSGVSADTIREWQAQAD
(957) DNA topoisomerase 1 [Natrialba magadii ATCC 43099]
3
MELIITEKDNAARRIADILSGGTYDSSRENGVNVYEWGGKRCVGLSGHVVGVDFPSEYSDWRDVEPVELIDASIEKTATKENIVATLRILSRKATRVTIATDYDREGELIGKEAYDIVREVDEEVPIRRVRFSSITENEVQDAFDEPDELDFDLAAAGEARQIIDLVWGAALTRFLSLSAGQLGNDFISVGRVQSPTLKLMVDREREIEAFDPEDYWELVADVAKGSEAQRASETSSGDEPRESEAFEAQYFYRDEDGNEAERVWEEAVAEDVFETLSQRDTATVVDVNRRTRTDSPPAPFNTTQFIRAASALGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPEELLDDFVGHPTLGESAESLLEADEIEPTEGDEETTDHPPIHPTGEIPSRGDVSDDEWEVFELVVRRFYATVAEAAIWEHLKVVAEVAAHRLKANGKRLDKAGYHDVYPYFSTTENYVPDVSEGEEITITDVELEDKQTQPPRRYGQSRLIETMEDMGIGTKSTRHETIQKLYDRGYIESDPPRPTKLAMAVVEAAENYADRVVSEDMTAQLEQDMDAIASGEAGLEDVTNESREMLEEIFANLADSRDEIGDHLRKSLKDDKRLGPCPECGEDLLVRRSRHGSYFIGCDGYPDCENTLPLPSTGKPLILDEECEKHDLNEVKMLAGRQTFVHGCPLCKAEDAGEGPVLGDCPECGDEHGGELAVKTLQSGSRLVGCTRYPDCEYSLPLPRRGEIEVTEEYCGEHDLPELVIHSGDEPWELGCPICNYQEFQARESESGSDLESLDGVGAKTVEKLAAAGIESLADLTEADPDSIAEDVDGVSADRIRNWQASA
(958) DNA topoisomerase 1 [Natrialba magadii ATCC 43099]
3
MELIITEKDNAARRIADILSGGTYDSSRENGVNVYEWGGKRCVGLSGHVVGVDFPSEYSDWRDVEPVELIDASIEKTATKENIVATLRILSRKATRVTIATDYDREGELIGKEAYDIVREVDEEVPIRRVRFSSITENEVQDAFDEPDELDFDLAAAGEARQIIDLVWGAALTRFLSLSAGQLGNDFISVGRVQSPTLKLMVDREREIEAFDPEDYWELVADVAKGSEAQRASETSSGDEPRESEAFEAQYFYRDEDGNEAERVWEEAVAEDVFETLSQRDTATVVDVNRRTRTDSPPAPFNTTQFIRAASALGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPEELLDDFVGHPTLGESAESLLEADEIEPTEGDEETTDHPPIHPTGEIPSRGDVSDDEWEVFELVVRRFYATVAEAAIWEHLKVVAEVAAHRLKANGKRLDKAGYHDVYPYFSTTENYVPDVSEGEEITITDVELEDKQTQPPRRYGQSRLIETMEDMGIGTKSTRHETIQKLYDRGYIESDPPRPTKLAMAVVEAAENYADRVVSEDMTAQLEQDMDAIASGEAGLEDVTNESREMLEEIFANLADSRDEIGDHLRKSLKDDKRLGPCPECGEDLLVRRSRHGSYFIGCDGYPDCENTLPLPSTGKPLILDEECEKHDLNEVKMLAGRQTFVHGCPLCKAEDAGEGPVLGDCPECGDEHGGELAVKTLQSGSRLVGCTRYPDCEYSLPLPRRGEIEVTEEYCGEHDLPELVIHSGDEPWELGCPICNYQEFQARESESGSDLESLDGVGAKTVEKLAAAGIESLADLTEADPDSIAEDVDGVSADRIRNWQASA
(1022) DNA topoisomerase 1 [Haloterrigena turkmenica DSM 5511]
3
MELIITEKDNAARRIADILSGGTYDSSRENGVNVYEWGGKRCVGLSGHVVGVDFPDEYSDWRDVEPVELIDASVEKTATKENIVATLRILARKATRVTIATDYDREGELIGKEAYDIVRDVDEEVPIRRVRFSSITENEVQSAFDDPDDLDFDLAAAGEARQIIDLVWGAALTRFLSLSAGQLGNDFISVGRVQSPTLKLIVDREREIQAFDPETYWELFGDLTKEDTTFEAQYFYRDEDDNEAERVWEEAVADEVYETLAERDSATVVDVNRRTRTDTPPEPFNTTQFIRAAGAIGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPEELLDDFVSHPTLGESAESLLEADEIVPTEGDEETTDHPPIHPTGEIPSRGGDVSDDEWEVYELVVRRFYATVADAAVWEHLKVVTEVDDYRMKSNGKRLVEPGYHDVYPYFSTSENYVPDVTEGEELALTDVELEEKETQPPRRYGQSRLIETMEDMGIGTKSTRHNTLEKLYDRGYIESDPPRPTKLAMAVVDAAENYADRVVSEEMTAQLEQDMDAIASGEATLDDVTDESREMLEEIFANLADSRDEIGDHLRKSLKDDKRLGPCPECGEDLLVRRSRHGSYFVGCDGYPDCENTLPLPSTGKPLILESECEDHGLNEVKMLAGRQTFVHGCPLCKAEDAGEGPVLGTCPECGDEHDGELAVKTLQSGSRLVGCTRYPDCEYSLPLPRRGEIEVTDERCDEHGLPELVVHSGDDPWELGCPICNYQEFQARESDSGSDLEALDGVGAKTVEKLADAGIESLDDLTEADPDAVAEDVDGVSADRVRTWQAKA
(1361) DNA topoisomerase 1 [Haloquadratum walsbyi DSM 16790]
3
MSQGPELIITEKDNAARRIADILSGDSATADREQGVNVYKWGGKRCIGLSGHVVAVDFPQEYSDWRDVEPVELIDAPIEKNPTKQNIVTTLKKLARRARRVIIATDYDREGELIGKEAYELVRRVNESTPIDRVRFSSITEESVTTAFENPDDLDFNLAAAGEARQVIDLVWGAALTRYLSLSAGQLGSDFISVGRVQGPTLKLIVDREREIEAFDPEDYWELFVDLTQADKPIEVSTDDTAAEFEAQYFYHADDGTEAERITEESTAKTVFETLESASIAHVDSVKRRTRTDEPPAPFNTTQFISAAGSIGYAAQRAMDIAEDLYTAGYITYPRTDNTVYPDELDPRELIEALTNGSRFGSDARDVLDQETLSPTTGDEETTDHPPIHPTDELPKPSELDDDKWEVYELIVRHFLATVSNPATWEHLRIVAIVDDTYSIKSNGRRLLNPGYHAVYPYSNATESLIPDIEDGETLRLIDSRIEAKQTQPPRRYGQSRLIETMESMGIGTKSSRHNVIQKLYNRGYIESDPPRPTQLARAVVEAAEEFAELIVSEEMTAQLETDMQAIAEGEETLESVTSASRSILTDVFKKLMNTDAEIGDHLQRSMKADKTIGPCPQCEGDLITRKSQAGSHFIGCDSYPDCEYTLPLPSTGKPHILETVCDVHNLQQIKMLAGKRSFVHGCPLCEAEAADEQADRVIGTCPECNAHADGELAIKRLRSGSRLVGCTRYPDCEYSLPLPRQGEIDVTDNICDEHALPALQILEADENTTKDKTTKESDDIWELGCPICNYREYQSDQTDSSTLESVHGIGAKTAEKLKDAGVDTVSALKSAEANTLADRVDGVSVDRLRKWQSTAD
(124) Topoisomerase IA [Methanopyrus kandleri AV19]
3
MASSSKETMVIIAEKPSLAGTIAGFLRGSWDGRKLLGFGRYRGRRFAITSLSGHVLEWWPKDDPGFRHPDYFPDPGDFELRPIDGKERFLRAVERVVKRYAGCRADRVIVATDNDAEGELIGWEVLVWLKRQGGLDDPECARRMRFSAYTREDVLRALEGALRGERIDPSLAYSALARTIADWLYGIPLTRRLSLCNDDIVSVGRVQTPTLKLVVERERERRKAQKKRRYYWILQAETPIGELRTEEKFKDGRRARELASEIESIRVVEVRRERRSVRPPTPFNLTTLQRAAGKILRISPKRTLDLAQRLYEEGMITYPRTATNRYPSTFDHEELLRKLRNAHPDALRDFQRTGRRSEPVSGKEYDGAHPPITPTGRRKYIRGKLAWRLYDLIVRRYLATLSEDALVVKWRIVAEHPGTGTRFVMEGTEVERDGWYSVYPWEKPRESTMPDVSEGDELPANVNASRRRKPLPRRYSQSRLVAKMKKLGLGTESTRAEIVKKLFDRGYVKRAGSGVAPTKRGERLVELLEDRVPELVSVELTRRIEREMEEISELPPKRARERLERVAREIRETVRRNSKKLKSAKVV
(865) DNA topoisomerase 1 [Methanoplanus petrolearius DSM 11571]
3
MHLIIAEKNIAAQRIAGILAENKKPSVKREEGVNTYSFDDKVAIGLRGHVVEIDFEPGYSNWRSETHTPKSLIDAGTIKKPTEKRIVQLIKRLAKKADHVIIATDFDREGELIGKEAYEIVRAANKTVPIKRARFSAITKQEITSAFANPAELDFNLAEAGEARQVVDLIWGASLTRFISLAAKRGGNNILSVGRVQSPTLAMIVDREKEIEAFVPEPYWMISLDSETEEEKFEARHTEGKFWDKESAERSLKGTKEPLTVIDIKEGTRADHAPTPFDTTAYIVAASRLGLSASNAMRIAEELYMNGYISYPRTDNTIYPSSLDLKGILTELKKSPFKREVEWVSANMRPSPTRGKKSSTDHPPIHPTAAASKGDMDETAWKVYELVVRRFLATLSPDARWKTLKYTFDAGGEPYASTGQRLDYEGYRIVYTYSQAKEQALPVLAAGEKLPILDIRLEEKETLPPPRYSQSKLIQVMEELGLGTKSTRHDVIGKLFSRRYVEGNPLKPTLVGRAVTESLEDHAGLITKPDMTRTLEEHMEEIKKSILSKDSVVQESREMLHEIFESLEANQEDIGSEIMDKTAEERVVGKCPVCGKSLMIRTTKGMAQFIGCTGYPDCSFNIGLPSGQWGKAIRDNKICEIHGMNHIRLVRKGSPPWDLGCPLCNHISSNLETLNMIPSISKDLISNLHSHNIYTVYEIANENPEKLSKVTGISKEDSEKLIREADEVLELLRKRSELKKFVRKIIPPKRGRSHAKVLNMFFDAGIVDMESLARADKKTLEKMKLSAEEAESLSHEARLVYNKALLKEYGVPAVSLKKYFDAGFVTPEDFCYIHPAYLSAKTGLNIDTVYKHAAIVCEATGVRLPEKVSKKELESGRIELLSIEGLGEAMLEKLYMAGIVSRKKLCSADPEQISKLTGIPSEKITYFQEECK
(254) DNA topoisomerase 1 [Methanoregula boonei 6A8]
3
MHLIVAEKNISAHRIAQILAGGTRVIEKKDAGVSTYSFGDTITVGLRGHVVEVDFEPGYENWRSEKYTPRSLIDAKTIKVPTEKRIVSLVQKLARHADRVTIATDFDTEGELIGKEAYELVRAVNKNVKIDRARFSAITAQEIGSAFANTTDLDFALAAAGEARQSIDLMWGASLTRFISLAAKRGGNNILSVGRVQSPTLSMIVDREKEIEKFVPEKYWQLGLLTEKAGEQIEARHTNGRFKDQKAAELARDRTKEPLVVTEVREGTKQDRSPSPFDTTTYIVAAARLGFSAANAMRIAEELYMNGYISYPRTDNTVYPASLDLNGVLATIRNSPFTKDVDWIISHRRAEPTRGKKSSTDHPPIYPTGVATREGIGDDAFRIYELVLRRFLATLAPDALWKTLKVNFEAGGETYTVTGGLLLEPGWHAVYPFSEAKETILPAFVTGEKLPIRKVNLEEKETLPPARYTQSKLIQRMEELGLGTKSTRHEVIARLVSRKYIEGNPLRPTLVGRVVTEALEQNADTITKPEMTQTIESHMQQIKESKRTRDDVIAESRSMLHKAFDQLEANEQVIGNDIRDRTAEELNLGRCPACGGTLAIKHMRGSTQFIGCSRYPECTFNIGLPVTQWGWAVRTDDICDKHHLHFVRLVRKGARPWDIGCPLCHHISSNAESLTEIPSMDEALLEKARSKHIYTVAEIARSEPDALAKSLDLPLEKAGKLKSEAGIVLEKLRRRSECRKFLRNHLIPRKGRSYAKIMEALGQSGVTDLASLAHATPATLQQAGIGETEARDLLTEARLTHNSQLLKGTGIPAVSLKKYLEAGVSGPEDFVSTGAEKLATLTGMSTGTINRHLALVCEYLHRPVPLAVPKAKLAKGRKELLSVKGLAATTADKLIGAGVISGDLLLAADTKKLAASTGIDEEKLRGYQALMKKKKENAIIRI
(1110) DNA topoisomerase 1 [Halorubrum lacusprofundi ATCC 49239]
3
MSRGPELIITEKDNAARRIADILSGESATAERENDVNVYKWGGKRCIGLSGHVVGVDFPAEYNDWRDVEPVELIDAPITKEPTQEGIVAALRKLARNASRVVIATDYDREGELIGKEAYELVREVNEDAPIDRVRFSSITDNEVNEAFANPDELDFDLAAAGEARQVIDLTWGAALTRFLSLSARQLGEDFISVGRVQGPTLKLIVDREREIKAFDPEAYWELYGNLTKSGGDPFEARYFYLNDEGNEAERVWNGDVAEVLTEAFDAADEAVVDDVRRRTRTDDPPTPFNTTAFIRAAGSLGHSAQRAMSLAEDLYTAGYVTYPRTDNTVYPEDLDPRELIEELSVASTFGKDAKSLLEQEEIEPTEGDEETTDHPPIHPTGELPSASDLSEDEWEVYELIVRRFLATCAEPATWERLRVVALANDEATAIAERADGLAALRNPEEASGPGDLVADGGLRLKANGKRLLEAGYHDVYPYRSSDERIVPDVEVGETLALTDRRTDAKETQPPRRYGQSRLIEEMEKRGVGTKATRHRTLEKLYDRNYIESDPPRPTRLAEAVVEAAEEFAEHVVSEEMTAQLERDMQAIAAGEKGYDEVTEASRELLNRVFDDLTESREAVGDHLQKSLKADKTLGPCPECGSDLLVRKSRQGSYFVGCDGYPDCEYTLPLPSSGKPLLLDETCEEHELRHVKMLAGRKTFVHGCPQCKADEADEQEDEVIGACPECGEEHGGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGEIEVTDEICEEHGLPHLRVHSGDEPWELGCPICNYREFTARQEGSELQTVEGIGEKTAEKLKDAGVDGVDDLKSIDPDELAADVDGVGADTVRDWQAKAD
(506) DNA topoisomerase 1 [Halogeometricum borinquense DSM 11551]
3
MSKGPELIITEKDNAARRIADILSGESAEADRINGVNVYKWGGKRCIGLSGHVVGVDFPPEYNDWRDVEPVELIDAPIDKHPTQENIVAALRRLARNARRVVIATDYDREGELIGKEAYELVRDVNEDVPVDRVRFSSITDREVTEAFDNPDGLDFNLAAAGEARQIVDLVWGAALTRFLSLSARQLGDDFISVGRVQGPTLKLIVDREREIEAFDPEDYWELFADLQKDSESFEAQYFYLDEDGNEAERVWDGDDAEEAYETLRNVEAATVDSVRRRTRTDDPPAPFNTTQFIRAAGSLGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPEDLDPRELLDAFTANRTFGDDAQNLLEQEEIEPTAGDNETTDHPPIHPTGELPSRSDLTEDEWDVYELVVRRFFATVAESAKWEHLRVVADAGGLSLKANGKRLVKAGYHEVYPYFNSSESFVPDVAEGESLAVTDTEIEEKQTQPPRRYGQSRLIETMEKMGIGTKATRHDVIQKLYDRNYIESDPPRPTRLARAVVEASEEFAELIVSEEMTAQLEADMQAIARGDASLDDVTAESREILEDVFEGLMESGDEVGKHLQKSLKADKTVGACPESDHDLVVRKSRRGSYFIGCDGYPDCTYTLPLPSTGKPLIMDEECDEHGLSHVKMLAGRKTFVHGCPLCKAEEADAEEDLIIGDCPECGAGAESETPQNGDGETDGEHGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGDIEVTDEECEEHDLPEIRITYDDSDREPWDLGCPICNYRAYQAEQAGGDELQSVKGIGEKTAEKLKAAGIEDVPSLKEAEPDALADLVDGVGPDTVRKWQSAAD
(507) DNA topoisomerase 1 [Halogeometricum borinquense DSM 11551]
3
MSKGPELIITEKDNAARRIADILSGESAEADRINGVNVYKWGGKRCIGLSGHVVGVDFPPEYNDWRDVEPVELIDAPIDKHPTQENIVAALRRLARNARRVVIATDYDREGELIGKEAYELVRDVNEDVPVDRVRFSSITDREVTEAFDNPDGLDFNLAAAGEARQIVDLVWGAALTRFLSLSARQLGDDFISVGRVQGPTLKLIVDREREIEAFDPEDYWELFADLQKDSESFEAQYFYLDEDGNEAERVWDGDDAEEAYETLRNVEAATVDSVRRRTRTDDPPAPFNTTQFIRAAGSLGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPEDLDPRELLDAFTANRTFGDDAQNLLEQEEIEPTAGDNETTDHPPIHPTGELPSRSDLTEDEWDVYELVVRRFFATVAESAKWEHLRVVADAGGLSLKANGKRLVKAGYHEVYPYFNSSESFVPDVAEGESLAVTDTEIEEKQTQPPRRYGQSRLIETMEKMGIGTKATRHDVIQKLYDRNYIESDPPRPTRLARAVVEASEEFAELIVSEEMTAQLEADMQAIARGDASLDDVTAESREILEDVFEGLMESGDEVGKHLQKSLKADKTVGACPESDHDLVVRKSRRGSYFIGCDGYPDCTYTLPLPSTGKPLIMDEECDEHGLSHVKMLAGRKTFVHGCPLCKAEEADAEEDLIIGDCPECGAGAESETPQNGDGETDGEHGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGDIEVTDEECEEHDLPEIRITYDDSDREPWDLGCPICNYRAYQAEQAGGDELQSVKGIGEKTAEKLKAAGIEDVPSLKEAEPDALADLVDGVGPDTVRKWQSAAD
(238) DNA topoisomerase 1 [Natronomonas pharaonis DSM 2160]
3
MELIVTEKDNAARRIAEILSDGSASTERRNGVNVYRWGDKRCVGLSGHVVGVDFPPEYEDWRDVQPVELVEADVVKKPTQENIVRTLKQLAGEADRATIATDYDREGELIGKEAYELIREEADIPIQRVRFSSITENEVKEAFATPDDLDFDLAAAGEARQIVDLLWGAALTRFLSLSANQLGDDFISVGRVQSPTLKLIVDREREIEAFDPDDYWELFADLAREGTTFEAQYFYREDGTEQERVWDESGAETAFETLRNAGTAVVESVRRRRRTDEPPEPFNTTQYISAANGIGLSAQRAMSVAEELYTAGYITYPRTDNTVYPDDLDPEALLSAFTDHYLFADDAEMLRSADDIEPTAGDEETTDHPPIHPTGEIPNKDDLSDDEWEVYELVVRHFFATVADAAEWEHLKVVADADGCSLKANGKRLVEPGYHEVYPYRSTSENHVPAVEEGEQLAIEDARIEEKQTQPPRRRGQSRLIEELESRGLGTKSTRHNTLQKLYDRGYIESDPPRPTKLAMAVVEAAEQFADRIVDEEMTAQLESDMQAIVDGEKDLEAVTEESRALLGRIFDELHDSREEIGEHLQESMKADRMLGPCPECGEDLLIRRSRKGSYFVGCDGFPDCRYTLPLPSQGEPTVIDEACTEHDLNHVKMLAGRSTFVHGCPQCKADEADETDDRIIGDCPDCGDNADGELAIKQLRSGSRLVGCTRYPECEYSLPLPRRGDIEVLDERCADHDLPHLRVVDNGDDPWELGCPICNYTEYREQQAASAIEDLDGVGQKTAEKLADAGIESLSDLRGADAEAVANEVQGVSEDRLREWQAEANVSASAD
(408) DNA topoisomerase 1 [Halorhabdus utahensis DSM 12940]
3
MRLIVTEKDNAARRIAEILSDDSASGERRNGVNVYKWGGQRVVGLSGHVVGVDFPPEYAEWRDVEPAELIDADVVTTPTRENIVATLRSLARKADEVVIATDYDREGELIGKEAYELIREETDAPVERVRFSSITEREVQKAFENPDEIDFDLAAAGEARQIVDLIWGAALTRFLSLSAKQLGNDFISVGRVQSPTLKLIVDREREIEAFDPDDYWEILADLAKDGQGFEAQYFYDDDGSEAERVWDEAAAEAAYADLSESGTATVTEVRRRTRTDDPPAPFNTTAFISAASSLGYSAQRAMSLAEELYTDGYLTYPRTDNTVYPDDLDPEELLGAFEGSYEFGDDAASLLDQDEIEPTRGETESTDHPPIHPTGELPDRDEVGADAWEIYELVVRRFFATVAEPATWAHLRVVAEAAGRSLKANGKRLLEEGYHAVYPYSSAGETFVPEVSEGDKLSIDAVELEAKQTQPPRRYGQSRLIQHMEEMGIGTKATRHNIVEKLYDRGYVEDDPPRPTKLAEAVVSAAEEYADHVVSEEMTAQLEADMTAIAEGEATLEEVTAESREMLGEIFEELRESRTEIGEFLQESLKADRTLGPCPECGEDLLVRRSRQGSYFVGCDGFPECRFTLPLPSTGEPQVTDETCEDHDLRHVKMLAGRDTFVHGCPRCKAEAADESEDEVIGHCPECGDSAAPEGQRNEGGEAAEGEGGKLAIKHLRSGSRLVGCTRYPDCDYSLPLPRRGEIVVTDERCEDHDLPHIEIHDGDDDDPWELGCPICNYEEFQARNAVENLEDLDGVGPATAEKLQDAGVADPEDLHEVDPDAVAGEVQGVSADRIREWQDELAA
(637) DNA topoisomerase 1 [Halopiger xanaduensis SH-6]
3
MELIITEKDNAARRIADILSGGTYDSSRENGVNVYEWGGKRCVGLSGHVVGVDFPDEYSDWRDVEPAELIDADVEKTATKENIVATLRIFARKATSVTIATDYDREGELIGKEAYEIVRDVNEDVPIRRVRFSSITENEVQEAFENPDDLDFDLAAAGEARQIIDLVWGAALTRFLSLSAGQLGNDFISVGRVQSPTLKLIVDREREIQAFDPEDYWELFADLAKDDTTFESQYFYRDEDDNEAERVWEEAAAEEVYDTLSQRDSATVVDVNRRTRTDAPPTPFNTTQFIRAAGALGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPEELLDDFVGHPTLGESAEDLLEADEIQPTEGDEETTDHPPIHPTGEIPARGDVSDDEWEIFELVVRRFYATVAEAAVWEHLKVVSEVEDYRLKANGKRLVEPGYHDVYPYFSTAENYVPDVEEGEELALSDVELEEKQTQPPRRYGQSRLIETMEDMGIGTKSTRHNTLEKLYDRGYIESDPPRPTKLAMAVVDAAENYADRVVSEEMTAQLEADMDAIASGEAGLEDVTDESREMLEEIFANLAESREEIGDHLRKSLKDDKRLGPCPECGEDLLVRNSRHGSYFIGCDGYPDCENTLPLPSTGKPLILESECEEHGLNEVKMLAGRQTFVHGCPLCKAEDAGEGPVLGECPDCGEEHDGDLAVKTLQSGSRLVGCTRYPDCEYSLPLPRRGEIEVTDERCDEHDLPELVVHSGDEPWELGCPICNYQEFQARESDSGSDLEALDGLGAKTVEKLADAGIESIDDLTEADPDAVAEDVDGVSADRIRNWQAEA
(1005) DNA topoisomerase 1 [Halomicrobium mukohataei DSM 12286]
3
MELIITEKENAARRIAEILSDGAATAERENGVNVYRWGTKRCMGLSGHVVGVDFPPEYSDWRDVEPAELVAADVVKSATQENIVATLRKLARRADEATIATDYDREGELIGKEAYELIREETDVPVDRVRFSSITDREVREAFANPDEIDFDLAAAGEARQVIDLVWGAALTRFLSLSARQLGDDFISVGRVQSPTLKLIVDREREIQAFDPEDYWEIFGDLQGDDAAFEAQYFYDDDGSEAERVWDEATAESVYEDLAALDAATVTSVRERTRTDAPPEPFNTTAFISAAGSLGYSAQRAMSLAEELYTAGYMTYPRTDNTVYPEDLEPDELLDEFVGSSTFGEDAESLLEQDEIVPTEGDEETTDHPPIHPTGELPPRGELDDDEWEIYELVVRRFFATVAEPAKWAHLRVVAEAAGHSLKANGKRLLEPGYHAVYPYSSASENVVPAVSEGDALTMSDVSLDAKQTQPPRRYGQSRLIKKMEDFGLGTKSTRHNTIEKLYDRGYIEGDPPRPTTLAEAVVEAAEEFADRIVSEEMTAQMEADMSAIASGEATLDEVTAESREMLDRVFEELADSREEVGDYLQESLKADKTLGPCPECGEDLLVRRSRQGSYFVGCDGFPECRFTLPLPSTGEPQVLDDSCEDHGLNHVKMLAGRDTFVHGCPRCEAEKADETDDEVIGACPECGEGAAPEEQRGEGGDSEAQSASDHSSGQSPREETAEAHGGKLAIKRLRSGSRLVGCTRYPDCEYSLPLPRNGDIVVGEDRCAEHDLPEISIVDDEDDDDPWELGCPICNYAEYQARNAIDDLEDLNGIGGATAEKLAAVGIDEPADLRAVEPDEIAANVQGVSASQIEDWQAELAD
(698) DNA topoisomerase 1 [Methanosphaerula palustris E1-9c]
3
MHLIITEKNIAADRIAHILAGKTYVEVKKDGGVSTYSFNDTVVVGLRGHVVEVDFEPGYTNWRSEVNTPRSLISARTIKAPTDKKIVTLIQKLTKKADHVTIATDFDTEGELIGKETYDLVKAVKPDVRVDRSRFSAITEEEIQTAFAAPAELDFALAAAGEARQLIDLIWGASLTRFISLAAHRGGKNILSVGRVQSPTLAMMVDREKEIEAFVPEPYWVLTVDSNKDGEPVLARHTTARFTDVAIAEEAKEATRAPLMVTEVKEGSKVDRAPTPFDTTGFIVAAGRLGFSAANAMRIAEDLYMHGYISYPRTDNTIYPRSLDLNGVLKTLQKTELSSAVIWVMANRRPVPTQGKKSTTDHPPIHPSGAATRAELGDERWKIYELVVRRFLATLSPDARWMTMKVLFTAGNEPYTTTGATLLEAGWRTVYPYSDATEHPLPRFAVGDSLPIEQVNLDRKETQPPPRYTQSRLIQQMEELGLGTKSTRHEVIGKLVGRKYIEGNPLRPTLVGRAVIESLEDHAAAITRPDMTQTIDAHMQQIKERKRTRDDVVTESRAMLNRAFDELEEHQSQIGEDIMGRTVEEMILGPCPVCGSDLRIHHIRNSSQFIGCTRYPDCRFNIGLPLTQWGWAIRTDTVCPTHHLNHVRLIAKGSRPWDIGCPLCHHIESNQETMVLIPSMTEEILGRLQQHHIYTVHEVADAPPEALASAAEISSTAAEHLKSEGEAVLGLLRLRSELRKFVRKQVPPRRGRSHAKIMKHLHANGINTIADLAKADPTLLRTAGVGEKEVTSLLMQAKEYCNDKTLRAIGVPAISLKKYYAAGIQSPEDFCRYHPVYLSVKTGISPDTTFRHAEMVCIAQNRPVPRKVTRAMLERGRAELLTIPGLGETTIEKLYSGGVIDGMTLASADPAALASHSGIPLKKVQEFQSRLPGSSQAS
(1119) DNA topoisomerase 1 [Methanospirillum hungatei JF-1]
3
MHLIIAEKNIAANRIAQILSGKDKVSAKKEGGVNVYTFGDKISIGLRGHVVEVDFVEGYTNWRSQERPPRSLIDAETIKRPTEPAIVKLIHKIAKKANRVTIATDFDTEGELIGKEAYELVRAVNPKVPIDRARFSAITKEEINRAFSEPSDLDFDLAAAGEARQVVDLIWGASLTRFISLAAKRGGGNILSVGRVQSPTLAMIVDREKEIESFIPEPYWEISLTTEKDGQSIIARHAEGRFTDKKLADAAYAGTKDPLVVTEVKEGKRVDRAPTPFDTTQFIVAAARIGYSAANAMRVAEELYMNGFISYPRTDNTIYPPSLNLDNILTTLEKTKFARDVAWVRKNRRTKPTEGKKSSTDHPPIHPTGVATEEQLGENWKLYELVVRRFLATLSPDAEWATMRIGMDATGQNYVATGSRLTEAGWRTVYPYSEAKDSILPVVKKGEKLKIQDLNLEEKQTQPPPRYSQSKLIQVMEELGLGTKSTRHEVIQKLISRKYIEGNPLRPTLVGKAVTESLEAHASTITRPDMTQKLEQAMEAIKVRNKSRDGVVDDSRKMLHQVFDELEPNEAVIGQEIMGQTDEELTIGPCPVCGKDLRIRRKGGSQFIGCNGYPDCTCNISLPGTMWGSAVRTKKVCEVHNLFHVSLIAKGARPWEMGCPLCQLIEQQKEHYAKMPAMTEALQQKLLDAKIFSLYELSKLEPAVLAKKLGITKKQAETLIHEANDVLDLIRRRSECKKFMKQFVPPKRGRSHTKVMNGFTESGINCIGDIASATIESLKKTGLSEEEAKTLKSEAISLIAKNQLKDIGIPAVSLKRYQEAGFLTPEDIASAHPAYLAFKTGISIETVGKHATLITQSLGKPDPVKISKKAFESGKIELTSLPGVGESTLEHLYRAGIFDKKSLISADPAKVAKSGGLSKDHLKKLQAAAVV
(417) DNA topoisomerase 1 [Methanosaeta concilii GP6]
3
MHLIIAEKHDAAKRIAQILSGNKPRPYRIGGVEAFKFDDKVVMGLSGHIVGVDYPPGYNNWQKVDCKELIRAEIVVRPINDKIVNALRSLGKEADRITVATDYDREGELIGVEALKIAKEANPRLREDRVRYSAIVKDEILKAFKNAGKVDYDLAASGEARQIIDLVWGAALTRYISLTSGRLGKEFLSVGRVQSPTLALIVDREKEIQSFVPKPYWEIYADLERDLRVQHARGRIWEKDEVDSIVARLGPVGIIRSIQTKPRVEKPPAPFDTTSFISAASGIGFSAANAMRIAEWLYVNGFISYPRTDNTVYPPSIDLVALTRLFLKGEFSKEAEKLLGGKMVPTRGKRSTTDHPPIYPTAPVNKSELKEEQWKIYELVVRRFFATLAESCVWDATSLKVDIGPEPFRASGARLVEPGWRYYYPYSKAEERILPALKEGERLRVLGHSVEAKETQPPARYGQGKLIKLMDELGLGTKSTRHDIISKLYARAYVQGNPMRPTNTAYAVVDTLQKYAPTITKPEMTQTLEKDMTQISEQKIKEDEVIEESRVMLTSVFDELSCNQEDIGQSLKDGLRTDKIVGTCEKCNSELIIRRGHRGSRFIGCSGYPECRFTLPLPRSGAVVVTDKVCEKHGMFHIRIINKGKRPWDLGCPHCNFLDWQAKKALELAEGKESGEGKGAKARPAKKTVRGSGAKAAKKASGPSNADGDGLARLPGIGPKTLEKLASAGIKTSGELAGANAKSLAAKTGLSEKKIAAWKSAAKALS
(390) DNA topoisomerase 1 [Methanosaeta thermophila PT]
3
MHLIIAEKHDAAKRISEILAGKKPTVTKVSGIDTFRFDDRVVIGLSGHIVGLDYPECYNNWHKVDYRDLIRAEIVSRPTQERIVSALRKLGREADRVTIATDYDREGELIGVEALCILQEVNPSIKADRVRFSAITKSEILRAFAQPEEVDFNLAASGEARQIIDLVWGAALTRFISITSGRLGKEFLSVGRVQSPTLALIVDREKEIESFQPKPYWEIYADLEKGIRVRHSKSRIWTRDEVDRILNSLSDVARVRSISKGERRDRPPTPFDTTSFISAASSIGFTAANAMRIAESLYTNGYISYPRTDNTVYPPSIDLRSLLEMLSSGPFREDALELMKGSITPTKGKRSTTDHPPIYPTSVADKDDLKEDQWKIYELVVRRFFATLSGECVWETTSISFDIGDEVFRANGSRILDLGWRRYYPYSRAEENVLPPLREGEGLKVLSHEVLSKETQPPARFGQGRLVKLMDELGLGTKSTRHDIISKLYARAYIHGNPIRPTKTAYAVVDTLQRHAPAITKPEMTRTLENDMLKIAERKITKGEVIEESRQMLEAVFDELLAHRKEIEDSLREGLRVDRIVGKCRLCGSDLIIRRGRRGARFVGCSGYPECRFTLPLPRGGMIVVTERRCETHDMNHIRIINRGKRPWDLGCPYCNFNNWQAKKGSKTQRMPELDDISGIGPKSRERLESAGIKTLEALVSTDPASISESTGISIKKIISWQESARSIIHKGEQGGEVPGSSTC
(879) DNA topoisomerase 1 [Methanosarcina barkeri str. Fusaro]
3
MHLIVTEKNIAARRIAAILAPKNPKKDRVSGVDVYRYEIVSDEEKQETVVVGLSGHIVGIDFPKEYNNWQKVESKTLINADIITTPINRKIVTALKGLGKKASRVTIATDYDREGELIGVEALNIIKQVNPDVPFDRVRYSAITPKAIEAAFSNATDVDFNLADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLSVGRVQSPTLSLIVDREKERNVFVPTPYWEIYAELQNTEGKTFSAQHSTRRFLDKKEATKAFKKLGKKAELKGIEKGKKTDQPPAPFNTTGFISAANSIGLSPANAMRIAEALYTNGYISYPRTDNTVYPETLDLRAQIEIFKEGPFKEYADALLEKAELIPTRGKKETTDHPPIFPASLAKESDLKEDEWKVYELVVRRFFATFAGPSEWETMRLKLDINGEEFKANGARLVEQGWRWYYPYNAPEDRLFPELHEGDSLKVIKKDMQDKETQPPGRYGQGRLINIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVMDTLEKYSPTITKPDMTKLLEENMDRIAEGKIKEAAVLEESRDMLKQVFSELDKNREKIVESLQAGLREDKIIGTCSSCGNELIIRRSKRGGRFIGCNNYPNCTFSLPLPRSGQIIVTDKVCEVHGLHHIRIINSGKRPWDLGCPQCNFIEWQKTQQEEQAQQPKKEKPKSIKDLEGVGKATAGKLEEAGITSVEALAEADPVELAKAIKTSVKRVKSWQVSCNGIVTVEGNSTAEGNSTVKGNCTVEDA
(101) DNA topoisomerase [Methanosarcina barkeri str. Fusaro]
3
MTIVAFAEKNKAASQIASILGEGEVERITVEGLPVYEFKWKGEEWLVMGLSGHIMNYDFPEQYNKWKEVNPGVLLEIDPQKLVTRTDYAAAVKNLAKRANKIVLACDYDREGENIGFEAKTLAEKVTNVPIERARFSSLSPKEVKKAFESLINPDYNMAMAAEARQILDLKMGAAFTRFVTLSVRERARTKDILSIGPCQTPTCGFVYEREKAIRAFQAKDFWKITAIFSAESGKEGGKEGRKEGRKEGKKERGDFEGTHRAGNIHDKEKAAEIFKRLKGTKEGLVAKKTVKETKTSPPNPLNTTEFLKRASKFLGISPELALEVAEQLYLAGFTSYPRTETNKYAEDFDFKSLVFDFARQKEYKPFAESILIAPIVPKNGEKDAHDHPPIHPIRAASRGEVSSAVNIPQAPEVYNLIARHFLANLMPAAVFEKTHLHLLVNEEPFDSSGTVLKDSGWLEAYPFENKKDKLLPFVEEGQKVGVKKLSNTKSKTSPPKKLTEAELLTLMDKNGIGTKATAPTHIETNKKRGYLETKGKTISILDTGFTLMDGLSLTVPILVKPEIRAKIEALIQEVEDGKKEFEAALYEGTTLIKEMYAQLEANKKELTSSIAGTIKDEAALEDKKNYIGTCKACGHVLRIVQTDSGRFVGCTGYPDCRNSYPLPKAGALTVLRSKECKKGGVAVLKVGNKYNWAVGIGPCFTCDLEKECYPPETVGPCPECDGSMFLINFKDTRFLGCTKRCGYTHSVPKTGKLTILDKTCETCGWKLFRLKDGDRPEEEFCINRRCTEGRKYWKKPGKGAETRIKEKASVSRPAASSVAKQAASSATSSAASPEVTQAKRKTSKVSAAGLKKSK
(1532) DNA topoisomerase 1 [Methanosarcina acetivorans C2A]
3
MHLIVTEKNIAARRIAAILAPKSPKKERVSGVDVYRYELGKGKSRQETAVVGLSGHIVGIDFQKEYNNWQKVDARALIDAEITTTPINRKIVTALRTLGKEADRVTIATDYDREGELIGVEALNIIKKVNPEVPFDRVRYSAITPKAIDAAFTNPTSVDFDLADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLSVGRVQSPTLSLVVDREKERNIFVPTPYWEIHVELETKAGETFSAQHSTRRFLDKEEATAVFKKLGKKAELKEIEKGTKSDLPPTPFNTTGFISAANSIGLSPANAMRIAESLYTNGYISYPRTDNTVYPETLDLRAQIEIFTEGPFKEFADALLEKAELVPTRGKKETTDHPPIYPASLAKESELKEEEWKVYELVVRRFFATFAGPSTWETMRLRLEINAEEFRANGARLLEPGWRWYYPYNVPEDRLFPELSEGEILKVIKKEMLDKETQPPGRYGQGRLINIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVVETLEKYSPTITKPDMTKLLEENMDLIAEGKIKEDTVLEESREMLQQVFSELDKNRDKIIESLQAGLREDKIIGNCSLCGNELMIRRSKRGSRFIGCSNYPNCTFSLPLPKSGQIVVTDKQCETHGLHHIRIINAGKRPWDLGCPQCNFIEWQKTQKEKQAQQPKKEKPKTIKDIEGVGKATAGKLEEAGITSVEALAEADPIELAKTIKTSVKKVKTWQISCNGGIVEDL
(720) DNA topoisomerase [Methanosarcina acetivorans C2A]
3
MTVVAFAEKNKAAAQIASILGDGEVDKISVEGLPAYEFKWKGEEWLVMGLSGHIMNYDFPEQYNKWSEVNPGTLLGVDPEKFVTRAEYATAIKKLAKRADKIILACDYDREGENIGFEAKTLAEEVTDVPVARARFSALSPKEVRKAFESPVDPDHNLAMAAETRQILDLKMGAAFTRFVTLSVREKARTKDILSIGPCQTPTCGFVYEREKAIRAFKAKDFWKITAIFGAKGGDFEGTHRAGNIHDKEKAAEIFKRLKGAKEGFVVKKTVKEAKTSPPNPLNTTEFLKRASKFLGISPEVALEVAEQLYLAGFTSYPRTETNKYADDFDFKTLLFDFARQKEYKPFAESILSAPIVPKNGDKDAHDHPPIHPIRVAAKGEISAAVTIPHAAEVYDLIARHFLANLMPAAVFEKTHLHLQVREEPFDSSGTVLKDAGWLEVYPFENKKDKLLPFVEEKEKVDVKKLSNTKSKTSPPKKLTEAELLTLMDKHGIGTKATAPTHIETNKKRGYFETKGKTVSILDTGFTLMDGLSLTVPILVRPDIRAKIEALIQEVEDGKKEFEAALAEGTALIKEMYAQLEANKKELTSNIAGTIKDEAALEDKKNYIGTCKACGHVLRIVQTDTGRFVGCTGYPDCRNSFPLPKTGALTVLRSKECKKGGAAVLKVGNKYNWAVGIGPCFKCELEKECYPPETVGPCPECDGSMFLISFKDSRFLGCTKRCGYTHSVPKTGKLTLLDKTCETCGWKLFRLKEEEKPELDFCVNRRCPEGRKYWKQAGSRTEPRDQAKVAAASSVPAPKVRAGRTPEAKSTPETRSMPRKAESPASGRVSKLSSTASRRKESK
(933) DNA topoisomerase 1 [Thermoplasma volcanium GSS1]
3
MQDYFRVIIAEKVDAGRRIAYFLSNGTAKARRVKGLSYIEFESNGKKTLLIPLSGHIVEADFPENFSNWEKTDLKELIDADIVKKVKNKSAYQTLSSFKGKADEIIIATDYDREGELIGVEALDIIKEGQEKVLRAKFSSLVGQEIRNAFEKPIDVNYNLADAADARESIDLIWGAVLTRFFSLATGRLGRYFLSAGRVQTPTLAIVVEREREIENFKPQTFWTISITFQKEGEFQAAYEKKLFDKDVANSVFSSINGRDGTVIKFEKHEESIRRPTPFSTTEFLREASRIGIMPTKAMSIAESLYTRGLISYPRTDNTVYPRAINLRNVLQKFSKSKYSNYVEEILGWEKIIPSRGRTETTDHPPIYPVEMPKEELKGDYARIYDLILRRFISTLYRDGRKTVKEAEIDVNGYKFLARGSQTTDLGWMAVYGYSSRDEFMPDLSEGEILHGTNWLLNEDQTKPPPRYDMASLLKKMEDLNLGTKSTRHDIIGKLIDRGFIEGNPVRPTGLGIAFIDAVKSVNSSIADPDMTAKLEQDMDKIERSLMSKQEVVDESKKMLHSVLGDFINKADDVKSIINTGINAGEAMGKCPFHPDHNLILSKDKFTYRIRCEVDGCRIDFKIKKNGSISLMDQLCPVCGLPLIKIIRRGQSPEVKCIDPGCAYNKEKEDFGECPKDGGRLILRQSRYGKRFLGCSNYPKCTVTYPLPQKGKIEKTGEKCPICGAPLLEAVNGKRRWKFCPNISCEYNKKKSNKVEEKKAGRRKKDASKS
(1190) DNA topoisomerase 1 [Methanococcoides burtonii DSM 6242]
3
MHLIIAEKHIAAKRIAKILAPKEPKQVRVSGMDTFEYKNPDAEDRIIVMGLSGHIVQLDFPKAYNNWQKIDANELIDAEVITTPTHVKIVAALRKLGKEATHVTIATDYDREGELIGVEALNIIRKVNPDVEFDRVFYSAITKTEIEGAFANPASIDFDLADAGHSRQVIDLVWGASLTRYLSISAGRLGKLFLSVGRVQSPTLALIVDKEKERQAFVSKPYWEVNATLKDNDDALVNVQHKNSKFWEKEEADAVMEVIGDKASVSSVDSSKKTDKVPTPFNTTEFIGAASSIGFTASNAMRIAESLYTNGFISYPRTDNTVYPASIDLRAQIEIFSKGPFREYAQKLLAKDELVPTRGKKETTDHPPIYPASLAKKSELNEQDWKLYELVVRRFFATFADEAEWETMKVRFDISGEEFKANGARLVHQGWRWYYPYNAPQDRLLPALSEGDILDVTGKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYVHGNPLQPTKTSFAVIEALEKYAPTITKHDMTSQLEEDMDSIAEGKVKEDNVLKESRTMLHEVFTELANNSENISESLRAGLREDKVIGECSECGSKLMVRRSKRGSRFIGCNGYPDCNFSLPLPKSGQIIVTEKTCEEHGINHVKIINPGKRPWELGCPQCNFIEWKKTQEEEKAKQPKVPIPDKITDVPGIGKVTAEKLKNAEINTIDELRQANAIELSKATSLPAGKIMKWQELVT
(1505) DNA topoisomerase [Methanococcoides burtonii DSM 6242]
3
MTTVVFTEKNKAAAQISTILSGGSAKRSIVDGVSVYEFQRDGSLWKIMGLAGHIMGYDYPEEFHNWRDVDPAALLDTDPVKQINKASFGSAILKISKGADLLVLACDFDREGENIGFEAKSIAEKVSDATVKRARFSSLSKSEIEKAFNDLVEPDENMAMSAEARQILDLKMGASFTRFVTLSVRERARTKGVLSIGPCQTPTCGFVYERELAIRKFDSRDFWKIEGVFTGKGADIIGVHRGGHIYDKEKAAAIFKKLKGCKTAVISKKTVKEMNTNPPFPLNTNEFLKRASKYLGVSPDQALEIAEQLYLSGFTSYPRTETNMYADDMDFASILKGFTKGDYQDFALLLLSQKAIVPRNGKKDGHDHPPIHPIKAGSRMEVERAIKMPRAWDVYDLIVRHFIANLLPPAVFEKTRFEITMEDELFDSTGSIQKNAGWLAVYPFEKPQDKILPALDLGEVLDVKKITNIKSQTTPPKRLTEAELLTLMDKHGIGTKATAPSHIETNKKRGYFEVKGKTIAILDTGFTLMDALNSSVPILVKPDIRSSIESLIQDVEDGNKKFELALEEGTSLIKEMYSQLLSNRDLMVTRIAGTITDEAVEADKKSHIGKCNECERVLRIVSTDKGRFVGCTGYPQCKNTFPLPKTGALAVQRSRTCKKGGAAVLKVGSKYFWAVGIGPCFSCDMEKECYPPEIVGECPACDGQTFLITTKDSRFLGCTKRCGHTQSVPKNGRLTITDKVCEGCGWRLLRVKEQGKDAKEYCANRKCEVAAQMRSSYRKK
(656) Reverse gyrase [Archaeoglobus fulgidus DSM 4304]
6
MIPVVYSNLCPVCGGDLESKEIEKHVCFRKKRSLCLFPEDFLLKEFVEFFRKCVGEPRAIQKMWAKRILRKESFAATAPTGVGKTSFGLAMSLFLALKGKRCYVIFPTSLLVIQAAETIRKYAEKAGVGTENLIGYYHGRIPKREKENFMQNLRNFKIVITTTQFLSKHYRELGHFDFIFVDDVDAILKASKNVDKLLHLLGFHYDLKTKSWVGEARGCLMVSTATAKKGKKAELFRQLLNFDIGSSRITVRNVEDVAVNDESISTLSSILEKLGTGGIIYARTGEEAEEIYESLKNKFRIGIVTATKKGDYEKFVEGEIDHLIGTAHYYGTLVRGLDLPERIRFAVFVGCPSFRVTIEDIDSLSPQMVKLLAYLYRNVDEIERLLPAVERHIDEVREILKKVMGKERPQAKDVVVREGEVIFPDLRTYIQGSGRTSRLFAGGLTKGASFLLEDDSELLSAFIERAKLYDIEFKSIDEVDFEKLSRELDESRDRYRRRQEFDLIKPALFIVESPTKARQISRFFGKPSVKVLDGAVVYEIPMQKYVLMVTASIGHVVDLITNRGFHGVLVNGRFVPVYASIKRCRDCGYQFTEDRESCPKCGSENVDNSRSRIEALRKLAHDAEFVIVGTDPDTEGEKIAWDLKNLLSGCGAVKRAEFHEVTRRAILEALESLRDVDENLVKAQVVRRIEDRWIGFVLSQKLWERFNNRNLSAGRAQTPVLGWIIDRFQESRERRKIAIVRDFDLVLEHDEEEFDLTIKLVEEREELRTPLPPYTTETMLSDANRILKFSVKQTMQIAQELFENGLITYHRTDSTRVSDVGQRIAKEYLGDDFVGREWGESGAHECIRPTRPLTRDDVQRLIQEGVLVVEGLRWEHFALYDLIFRRFMASQCRPFKVVVKKYSIEFDGKTAEEERIVRAEGRAYELYRAVWVKNELPTGTFRVKAEVKSVPKVLPFTQSEIIQMMKERGIGRPSTYATIVDRLFMRNYVVEKYGRMIPTKLGIDVFRFLVRRYAKFVSEDRTRDLESRMDAIERGELDYLKALEDLYAEIKSID
(1326) DNA topoisomerase 1 [Archaeoglobus fulgidus DSM 4304]
3
MVMSWLIITEKDNTARRIASILFKDVKTLKKGRVSYYHSPSNDAYVVGLKGHIVELDFPKELNNWTKTPLEKLLQAELVKKVKERTISSILKEIAKKADRVTVATDYDREGELIGVEALEIVKSVNPTVKVDRVRYSAVTEKEIRSAFSKPVKVDFNLANAALARQKIDLIWGATLTRLISVHSGRMGKDFLSVGRVQTPTLRLIVDRELEIQNFKPEKYYEIFAEFEGFIAKHPKRYGSKEEAEKLFAKIGETAKVEEFTRRRMEENRPTPFNTTEFLREASKFMSPHKAMNIAETLYMNGYISYPRTDNTVYPPTINLIEIVSALSSVFPREAQIVLSQDKITPSRGRRETKDHPPIYPTGVAKRGELSKDEWTIYELVVRRFLATLAPKAVWDVRRVVLDSNGVKFVANGRQLVEAGWRDIYIYSKAEETELPLLKKGDVLRILKKRLEEKETKPPGRYSASSLIKMMEKLNLGTKSTRHEIIQKLVSRRYIHGNPFRPSETAFSVINVLKETAETITLPDMTAKLENEMDLIAEGKKREPEVVDESREMLLQILRAIDYRKLSKDLREGVKKDKIVGKCPECGGELVVRQSKAGKRFIGCSNYPDCTFTLPLPQNGTLYITAKQCKEHEIKEVKIRTKKGYWNLGCPYCNYLNWKKENS
(711) Reverse gyrase [Ferroglobus placidus DSM 10642]
6
MIPVKYANLCSVCHKDVTWEELEKSYCRFKKLPQCSSFLDKIYKEFEEFFKKIIGEPRSIQKFWAKRVLSFESFAAVAPTGIGKTSFGSAMALFLALKKRKSYIILPTTLLVAQVVENLKKYCEKAGIDCGLNEEKEVTIAYYHGKLKEKDKFFEILEKNSFDILVTTTQFLPRYFEKLNGKIFNFIFVDDVDAVLKASRNVDRILKLLGFRYKNGKWEGKPKGVLMVSTATAKKGQKVKLFRELLNFDVGTSTHAVRNIDDVYVERADVEAVKEILRKMGSGGLIYARSSEEAEELYNSLKDEFKVGLVTAQRKKDFVLFERGEIDYLIGTAYYYGTLVRGLDLPERIRFAVFFKAPVFRVRIEDIDTISPGMVRVIALIFKEDERVKKFIPYLPKITEGTKEFEELKSILKKVIAERKKEVKDFVLREGEVIFPDVRTYIQGSGRTSRLFAGGITKGASFLLEDDEDVLKAFVERARYFDIEFKKIDEVDFESLIREINESREKFRRRAEFKDVIKPTLFIVESPTKARQISRFFGQPSVKVIGDENDVHVVAYEVPTPERILIVTASLGHVTDLITNRAFHGVEVNGIFVPIYASIKRCRDCGYQFTEERENCPKCESSNIDDSKKRIEALRRLAKETGEVIIGTDPDSEGEKIAWDIKNLLSGCATIKRAEFHEVTRRAVTEALANLRDVDENLVKAQIVRRVEDRWIGFILSQKLWEVFKNRNLSAGRAQTPVLGWIIQRAEENKKKKTVAFVKELGLSLEGIAKKELELEIELIEKKEEERTPLPPYTTDSMLRDANAILKMSAKDAMQIAQELFEHGLITYHRTDSTRVSEVGLRIAKEYLGEYFTPREWFAEGAHECIRPTRAIDRDTLQRLISEGIIVVENFTWRHFALYDLIFRRFMASQCKPYKVVVAKYRIKADGKEFEEERIIKAEGRAYELYKSVWVRNELPTGKIKVEAEIRRVPAAPLYTQSDVVALMKERRIGRPSTYATIVDKLFQRNYIIEKGGKLVPTKLGYSVYEYLINNYRSFVSEERTRLLEEMMDKVERGEADYFETLKEMYNEVKQI
(397) DNA topoisomerase 1 [Ferroglobus placidus DSM 10642]
3
MWLIVTEKNQTAKRIAQILFGSFQTKKKYGVNYYLNGDACVVGLKGHVVEYDFPPEYNDWKRVELKSLLNARIVRVVKEKSIVRLLEELAKKADRVTIATDYDREGELIGLEAVQIIKRVNPDVRIDRVKFSAITPEEIRKAFSSPGKINVNLAKAAETRQIIDLLWGAVLTRLISLSSGRLGRDFLSAGRVQSPTLRIIVDREKEIREFKPEPYWEITAKFERGVEAKIPRRFKDKEEAKRVYEKIGDGVVKSFEEVERVEKKPIPFNTTEFLKEASKFMPPDKAMAIAENLYINGYISYPRTDNTVYPQSLNLKKLVKMFLGSEFDKEARIALEDMKPSRGKKETKDHPPIHPTALAERKELSKDEWIIYELIVRRFLATLAPDAVWMVRKAEIISGGEKLVASGKELIKSGWRAIYIYSKAEDVFLPKLRVGERLKLLSKKLHEKKTKPPSRYSTSSLIKLMEKLNLGTKSTRHEIIRKLYSRGYVRGNPVKPTETAFSVVEALKKLYEPITLPDMTAKLEEDMNKIEEGKVDPKLVVKESVEFLRRVLESADKEELSKILSEGINKDKIVGSCPECGGNLVVKKAKGRFVACSNYPDCKFSLPLPQKGSLYVTAKTCKEHGMKFVRIKPKKGKSWEFCPYCSYLSWINR
(890) Reverse gyrase [Thermococcus sp. 4557]
6
MKAIYREMCPNCLGRISDERLINKNPCSECLDDTVTADSYFDLITAVRSALKLRGTLKEWERIYSLENGLREVEGFFEKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHATRGKKSYIVVPTTPLVVQTARKIRKIAENAGVEVNLAYYHGNLRKKEKEEMLAKIQNEDYGILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDEVIGKAWEIIRLKKQMSKYLNGRAKDREERLKELNAQIAELQRDIEEFKRENPIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVADTYLKPSKDIKEHVEDLLTMLGRGGIIFTPIDQGLGYAEELADYLRERGFRIELVSSKNRKAIERFENGEADYLIGSATYYGSLVRGLDMPHLIRYAIFTGVPKFRFSIDLERPTIYRALGLLSEVMDFLSDEDRKQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLKDEEVLRKLAEDPFISLKEEDGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLLRQMRWRFTEFKMVPFKELDLDEVLRQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVLVDEKDGMLKFIPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSTNVRDALQNVKAMRELAQEVDEILIATDPDTEGEKIAWDIMNVLSPYTPNIKRIEFHEVTRPAIMRAIEEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWVIERYKEFTESETYFMGLTLENDLRVTIELGKDGKGIEPPEYVTVEDVQLEERELKPSPPYTTDAMLKDASTFLKLSAPEAMRIAQDLFEMGLITYHRTDSTHVSNTGIEIAKEYITQELGEEYFKPRPWGEEGTHEAIRPTRPIDTGRLMQLIRDGILQLPKNLTRNHYRLYDMIFKKFMTSQMKAARIIHERAVIDAGIGKTEVEGYVEVVEDGWTRLRSPPMRQLPMLEKGARLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVQTLLQRYYAIETRGRKKLVPTDQGIKVYHYLISKYKDLVNEEKTRGLEEMMDRIEEGSVDYQEVLNALYRELQGYLGNGKPQ
(1327) DNA topoisomerase 1 [Thermococcus sp. 4557]
3
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVGYYEFTRDGKRIIVAPAVGHLFSLAPKVKTYGYPIFDIEWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVIGYTALKYACGIDPSRAKRMKFSALTKKDLLKAWYNLEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWQVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMLLEKNGEQYTAVYEKERILDEDEAKRIVEEAKKGPAFVEKVEVKQQKRNPPVPFDLGTLQREAYSAFGYSPKKTLELAQKLYERGLTSYPRTSSQKLPKNLNFRPILQNLAKLPEYKPFAHELLGKERLKPVEGKKEDPAHPAIYPTGELPKPGDLTKDEQNLYDLIVRRFLALFMEPAVREIMKVVINSNSHRFILGGARTVKEGWLKVYGKYVKFDEVILPAFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKRMEDLGIGTKATRAQILETLYSRGYIEGKRKIKVTPLGMRVVEALEKNVPDIVSVELTKAFEEKMAEIMAGKADREDVIEESKNQLIKILKVFKEKELDIGKMLMETTGTGATTSKTAARKAGAVKELSGEEEKAVKKAVDGGERRKEPLVLGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLLQRGEIIPTDKTCCGGAPVVKIREKGREYEICVDMNCRDWKKGKK
(846) Reverse gyrase [Thermococcus barophilus MP]
6
MKAIYREMCPNCEDRISDERLYKKHPCDVCLDREIQAEIYFDLITGIREALKLRRTLKHWENIYKLEKKLREIEDLFEKATGFNFWSAQKTWVKRLIKNKSFSIIAPTGMGKSVFGSFMALYYAKKKKKSYIVLPTTPLVVQTIKRVKTFAERAGIEINLAYYHGGMKKKEKEEMTEKIMSGDFDILITSAQWLARNFDEMLKDKRFDFIFVDDVDAFLKASKNIDRSLILLGFTEEIIQKAWEIIRLKKQMAKFLNGNSPDKQEQLKELNKQINKLEREIRKFKRENKIGVLIVASATGSARGDRIKLYRELLDFEVGSGRSALRNVVDSYLFPEKSIEEHVEELLTKLGKGGLIFVPIDQGISYAEKLTQYLQEKGFKVELVSARNKKGLEKFENEEIDYLVGVATYYGTIVRGLDLPHLIRYAIFTGVPKFRFSLDLEQPTIYRVLGLMSEVMEFLDEEDRREGERLYARLRRLIRNIPQFELMKIEEALAEGLPLEGFHSHVLEVFKQSVEFLRRVLKKEEVLKRIEEDPFVSLKEEEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDNEKVFNGLKRQMRWRFAEFEMKPFEELNLEELLREIDSDREKVRLILAGKISEKTKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDRMLTILASGGHMFDLVTTEGYHGVLIEERDGKLYFIPVYDTIKRCRDCGHQFVDWEERGVCPRCGSRNVRDALENVIAMREIAQEVDEILIGTDPDVEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKALNEARDVNEFRVNAQLVRRIEDRWIGFELSQKLWEVFESRNLSAGRVQTPVLGWVIQRYKEFVESETDFMALTLENGLSVTLEGVKDEVNEIIVEDVQIEEKEINPFPPYTTDTMLQDASRFLGFSAPHTMQLAQDLFELGLITYHRTDSTHVSNTGIEVAKEYISEEIGEEYFAPRKWGEEGAHECIRPTRPIDTGRLMQLLRDGIITLARGLTRDHFRLYDMIFKRFMASQMKAAKVLYEKAVIDARIAKTEIEGYVEIIFDGWTKLRAPPLKQLPRLEKGQKLKVIEVKKWRAPKVSLYTQGDLIALMKERKIGRPSTYAKIVKTLLDRHYVIETKGRKKLVPTELGTKVYHYLISKYKELVSEERTRQLEELMDLVEENKADYQEVLSNMYEEIKQYILK
(899) DNA topoisomerase 1 [Thermococcus barophilus MP]
3
MVTLIIAEKPNVAKKIAYALAERKPIRKTLYGVPYYELSRDGKKIIVAPAVGHLYTLAPKTKTYGYPIFDIEWVPVYVAEKGKSYAKDYIKALRELAKRADEFIVACDYDTEGEVIGYTALKYACGVDPKKAKRMKFSALTKRDILKAWYNLEPTINFGMADAGIARHILDWYWGVNLSRALTHAIKRASGKWMILSTGRVQGPTLKFLVEREKEIANFKPTPYWVIKMTLEKNGKQYTATYEKERILDEEEAKRIVQEAKKGPAFVEKVEVKQQKRNPPHPFDLGTLQREAYSAFGYSPKKTLDIAQRLYEMGICSYPRTSSQKLPKNLNYKYIIQSLAKIPEYKPFAHELLGKPQLKPVEGQKDDPAHPAIYPTGELPKPGELTQEEKNIYDLIVRRFLAAFADPAVREIMKVIINSNNHHFILSGARTVKEGWLKIYGKYVSFDEVILPKFREGEPVKVIQIKREKKKTKPPARYSPASVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIRVTPLGMKVVEALEKNVPEIVSVELTREFEEKMDEIMKRKLSKDRVIEEARGQLIKILREFKAKELDIGKELMEKLLEREKNKKSKKKTAKELTAEEEEAIKNAVENHEKKSNNLIIVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPSCDVTYPLLQRGKIIPTGKVCPECNAPVVKIKEGKKEYEVCLDMKCKKKMDKNKY
(726) Reverse gyrase [Thermococcus sibiricus MM 739]
6
MKAIYKGMCPNCEDKISDERLYKKHPCEICLEDEITSDTYFDLISGIREGLRVRNRIKQWEGVYSLEKKLIEAETLFKNATGFTFWSAQKTWVKRLVKGKSFSIIAPTGMGKSVFGAFMSIYYAKYGKKSYIILPTTPLVTQTIKRVKTFAENTGIDVNLAYYHGNMKKKEKEEMIQKIQTGDFDILITSGQYLARNFDLIKDKKFDFIFVDDVDAFLKASKNIDRSLILLGFNEEMIQKAWEIIKLKKLMAKYLNGNRKDKNEQLKELNKQINIIEKEIREFKDKNKIGVLIIASATGSARGDRIKLYRELLDFEVGSGRSALRNVVDSYLFPENSIEEHVKELLKVLGPGGLIFVPIDQGIAYAERLTNYLQDLGFKVELISARNKKGLQRFENGEVDYLVGVATYYGSIVRGLDIPHLIRYAIFTGIPKFRFSIDLEQPTIYRVLGLMSEVMDFLENEDRKNAEKLHAQIRRLIRNIPQFEILKIEEALAEGLPLEGFSNHVLKVFKEAVQFLRMILKKEDVLKRIEEDPFISLKKEENKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVIIVDNEKVFNGLKRQMRWRFAEFEMRPFHELELEKLLQEIDADREKVKFLLEGKIAEKTKDLVKSALMIVESPNKARTIANFFGHPSKRRIGDLVAYEVSIGELMLTILASGGHMFDLITNDNYHGVLIKEKEGKLYFIPIYDTLKRCRECGHQFVDWESKGVCPRCGSNDVRDVLENVKAMREIAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPTIKRIEFHEVTRPAILKALKEARDINEGRVNAQIVRRIEDRWIGFELSQKLWEVFENPYLSAGRVQTPVLSWIIQRYKEFVESEINFVQLTLENDLSVVLEDVKDGVEEVVVEDVHLEEKEINPLPPYTTDTMLQDASRFLKFSTDYTMRLAQDLFEVGLLTYIRTDSTHVSNVGIEVAKEYITDEIGEEYFVPRKWGEEGTHECIRPTRPIDTGRLMQLLRDGVITLARGLTRDHFRLYDMVFKRFMTSQMKATKVLYEKATIDARIAKAEVEGYVEILYEGWTKLRNLPLKKLPKLEKGQKIKVKETKKWKAPKVPLFSQGDIIALMKEHKIGRPSTYAKIVKTLLDRHYVIETKGRKKLVPTELGTKVYHYLITKYKDLVSEERTKQLEELMGLIEEDKIDYQEVLTELYKEIKKYTA
(1579) DNA topoisomerase 1 [Thermococcus sibiricus MM 739]
3
MTTLIIAEKPNVAKKIAYALAERKPIRKTIGKVPYYELTRDGKKIIVAPAVGHLFSLAPKERTYGYPVFDIDWVPVYLAEKGKSYTKDYIKALKELAKQADEFVIACDYDTEGEVIGYTALKYACGVEPSKAKRMKFSALTKQDLLRAWYNLEPTINFGMADAGITRHILDWYWGVNLSRALSSAIRKSSGKWHVLSTGRVQGPTLKFLVDREKEIENFVPTPYWVIKMILEKNGEQYTANYEKDRILNEEEAKRIVEEAKKGPAFVEKIEITQQKRSPPYPFDLGTLQRESYSAFGYSPKKTLEIAQKLYEKGYCLHPDSLIPTPKGVKKIEELPKEGEVFALDFDLKLSRARYRLLERDADELMYKVTLSDRTELYLTGDHPVLAYRDDRLIFVPAEELKDDDQVVLLINPWKFQSASETPKLFDFILKNASSMKDYILYDQSFGSVIRNRIKKAGLKVEILWKFKIKEPTYYKYLRGKMPVPVFKFLIERGVISKEEAREVFKGFSYSTSLSAVSFEFNEDFWYLYGFVVGDCHLDKRGQITIGARDRTEETIMAIQEVANSIGVRFAYDSRYKIIRLGSKSLVRLFELLGCPYGNKMKIFEIPGEVMAKPGWMASFLAGYYDADSHIGTKSTGGRKSLSPQIVLTSKNRRAIYTVKLMWQLLGVGTYLWERKDKNGNLMAYELKVYSRDSLKFYEIMKDHLRVKRCDLEKVRNAAIRKRKSYSHHYSVLKVTDWNGKLKSNKKLWKEFDISNQTAHGRGISLDKLRRIRDYLTDEDLRRIATGDVYILGIKSIEKFHYCGKVYDLVVEDYHNFIANGVVVHNCSYPRTSSQKLPKNLNFRSIIQNLAKIPEYKPHAHELLGKGILKPVEGKKDDPAHPAIYPTGEVPKPGDLNKDEQNLYDLIVRRFLAAFAEPAIRESMKIIINSNKHHFILNGSRTIKEGWLKIYGKYVKFDEVILPKFEKGEKVNVIQIKKEKKKTKPPARYSPASIIKKMEDLGIGTKATRAQILETLYSRGYIEGKKKIKVTPLGIKVIEALENNVPDIISVELTREFEQKMEEIMARKLKKERVIEESKTALIKVLKEFKNKEGEIGKKLLETFLENEKNKKSKRKNVKELKPEEEKVIQVEADFENKGKEKIIVGSCPKCGGDLVVRYNRRTGKRFVGCSNWPNCNVTYPLLQRGQIIPTGKTCSECGNAPIIKIKERNREYEVCLDMNCNKNRKKK
(362) DNA topoisomerase 1 [Pyrococcus horikoshii OT3]
3
MILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKRDVFGYPIFDIEWVPVYIAEKGKEYAREYIKALSVLAKRVREFIVACDYDTEGEVIGYTALKYACGVDPRVAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKLIFEKNGQKFTANYEKDKIWEEEEGKRIVLEVKKSIPRVSNVEIKRQKRTPPHPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFSSYPRTESQKLPRNINFRMIIQNLAKMPQYRPYAHILLGLPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEEKLYDMIVRRFLAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVKKGWLSVYGKYVKFEEVTLPEFFIGERIKVIQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGRLTKEEVIEEAKERLTKILEEFKKRELEIGIELAKIVVGEDEVKPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIREEDGREFEICLDINCKDWKAKSH
(544) Reverse gyrase [Pyrococcus horikoshii OT3]
6
MKAIYRGMCPNCRGAITDERLSNKNPCEGCLSEPILSEDYNELIVAVRNALKLRGTLKDWEELYRLNKEVSEIEELFEKSTGFKFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYFATKGKKSYIVVPTTPLVIQTVKKIESMLEKANVSVRLVYYHGNLRKKEKEEALEKIRNGDFDILITSSQFLATRFKELLKDKKFDLIFVDDVDAFLKASKNIDRSLIMLGFSEEIIGRAWEVIKLKKQLAKLLQNEKKNEEEIEKLNKEIEKIEDEIEEYKRRNKIGILIVASATGSAKGDRIKLYRELLGFEVGSGRSVLRNIVDTYLLPEKPIEEHVVELLRKLGKGGLIFVPIDKGIEYAEELTDYLKSQGFKVELVSAKNKKGLELFEKGEIDYLVGVATYYGTLVRGLDLPHLIRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEEKKSEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFHNHVLEVFKQSVEFLREVLKDEEVIKKIAENPFLSLKEIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFDIKKFEEVNLKEVLKEIDRDREKVKLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRKIGDLTAYEVSIGDKMLTILASGGHMFDLVTNEGYHGVLILKNNGKPYFVPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLAPYAPNIKRIEFHEVTRPAILRAIREARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGIILENGINVTIENAKGEVREVEVKDVIIEEKDVNPLPPYTTDTMLQDASRFLGFSATKTMQLAQDLFEAGLCVTPDTLVSLSDGRIIEIREAVENSEESLLGINGLKPKEAKALKFWEIDWDGPIKVIKLKNGHEIKATPDHGLLVMRDGKIGWVSAKNIREGDYVAFIYNLGHRGGKKYTLPQLLKELGISEYENSSSQELNNREQEMDSKQISIELDERFWYIFGVILGKGTLKGDKVVIFQKDVKPVIEEALPFVRIFESADHIGFSHLILAEVFRRLGVGEGKLHSLVFGLREEYINAMIAGYFDASGTFLRRAVLTSKRGDILRMLSVYLYQIGIVNNLRRDEHAGVWELIISDLEKFREKIYPYLRIKKSQFDKVYSISKNEGDFLPVASIFRKLKFRDGFKNRILDEEIPRDEVAKVLEYAEDSPEKEFLNSLVEARVTWVRVEKIEERHYTGKLYDFTTTTENFISNGIVSHNCTYHRTDSIHVSNTGIEVAKEYITQEIGEEYFTPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITIPKNLTRDHFRLYDLIFRRFMASQMKPAKILYEKAIISTPFKDVEVEGYIDVLYDGWSKIKSLPLRQIPKLEKGQRLRVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLITKYKDLVSEERTRQLEKIMDMVEEAKADYQDVLNELYEEIKRYVR
(117) DNA topoisomerase 1 [Thermococcus kodakarensis KOD1]
3
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVSYYEFTRDGKKVIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKQADEFVVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNMEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVEREKEIQNFEPKPYWVIKMLLEKNGGQYTAVYEKEKVWDEEEAKKIVEEAKKGPAFVEKVEVKQQNRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQKLYEKGYCLHPDSLIPTPQGVKRIKELPEKGEVFALDFDLKLSRARYRLLERDADEPMYKVTLSDRTELYLTADHPVLVYRDDQLIFVPAEELRENDQVVLFINRSEYSPRTESPTLLGFLLENATSMKDYILYDPEFGGVLRNRIKDAGLKTEILWRFRIREPTYYKYLRGKMPVPIVRFLLEEGVVSIEELREVFRGFSYSTSLTPISFEFSEEFWYLFGLVAGDGHLAKKGAITIPAKDRTEDTVKAVKEIANSLQVPFAFDEKYKMIILRSKSLTRLFELLGCPYGNKTEIFRIPGEIMAKPEWMAAFLAGYYDADGHIGTKPTGGKKSHSPQIVLTSKNRMAIYTVKQMWQLLGVGTYLWEKKDRNGNFMAYELKVYSRDAWRFYEVMKNHLRIKRKDLEHVKEVAIRKRKAYSHHYSVLNVKSWEGKIKSSNVLWKKFDMSNQTAHGRGISLDKLQRIVDYLTDTDLRRIAMGDVYVLGIRSIEKFHYRGKVYDLVVDQYHNFIANGVVVHNCSYPRTSSQKLPKNLNFRSIIQNLAKLPEYKPFAHELLGKESLKPVEGKKDDPAHPAIYPTGELPKPGELTKDEGNLYDLIVRRFLALFMEPAVRETMKVVINSNNHRFILSGARTLKEGWLKVYGKYVKFDEVILPAFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIKVTPLGMRVVEALEKNVPDIVSVELTRAFEEKMEEIMAGKADKDQVIEESKEQLIKILQVFKEKELDIGKMLLESTGTGVTTSKEAAKKTGAVKDANDEEKSDGKAGEGTTPKAERKPLVVGKCPKCGGDLVIRYNRKTGKRFVGCSNWPKCDVTYPILQRGQVIPTEKTCCNGAPVVKIREKGREYEICLDMNCKDWKKK
(382) Reverse gyrase [Thermococcus kodakarensis KOD1]
6
MKAVYREMCPNCWGRISDERLVMRNPCEECLDEPVHADSYFQLVSAVRNALKLRGTLKEWEKIYQLENQTREIEEFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHALKGKKSYIVVPTTPLVIQTVRKIEGIMENANADVRLAYYHGNLRKKEKEEMLERIKNEDYDILVTSAQWLARNYEEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFTDEIIQKAWEIIRLKKQMSRYLNGNSEDRNEKLNGLNREIEKLQREIEKFKRKNKIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTKDIKEHVEELLTRLGKGGLIFVPVDQGLGYAEELANYLSEKGFKIELVSSKNKKALEKFENGEADYLIGSATYYGSLVRGIDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSEEDRRQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLRDEEVLRKLAEDPFISLVKEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEFKMVPFEELDLDEILRQIDEDREKVRLVMEGKISAKVKDLVRSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEISVGDRMLTILASGGHMFDLVTNEGYHGVLIQNEGDMLKFIPVYDTLKRCRDCGHQFVDWEKKGVCPRCGSTNVRDALENVIAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRIEFHEVTRPAIMKAIQEARDVNENRVNAQIVRRIEDRWIGFELSQELQRVFESYNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTIELGKDGKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTLVSLADGRIMEIKDAVEKSEGNLLSVNGLKPKEAKALKFWEIDWNGPLKVIKLKNGHEIKATPDHGLLVMREGKLGWVSAKNVREGDYVAFAYNTGHRGRDEYTLLKLMIKLGITDVMVELDEEYFNEKVAPIVRERISTSTKYKYLRRRVLPLYLLQEWGLDDYEAHVKSLYRQRAGSKPIPNFKLDGRFWYVFGLVLGDGTLRDSKVLISQTPLKDVKSVLEDVFPFLRVFETTNQVGFSNSIIAEVFRRLGARKGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNDRKGPNFRGILTSKRGDVLRMLSVYLYQIGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYLRIRRAQFDEAYSVYRASRRAFEGDLLPVAPVFGKLKFKNGTKNRILKETGIDVWNWLKRPEGEIPRDKLSKVLEYAEESPEKEFLKSLVEAGVTWVKVKGVEEELYTGKLYDFTTTTENFLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPRPWGEEGAHEAIRPTRPIDTGRLMQLIRDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKAELEGYVEIIEDGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVETLMRRGYVVETKGRKKLLPTEKGIKVYHYLVSKYRDLVSEERTRELEEIMDRIEEGIEDYIKVLGELYSEIQRYVSG
(381) Reverse gyrase [Thermococcus kodakarensis KOD1]
6
MKAVYREMCPNCWGRISDERLVMRNPCEECLDEPVHADSYFQLVSAVRNALKLRGTLKEWEKIYQLENQTREIEEFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHALKGKKSYIVVPTTPLVIQTVRKIEGIMENANADVRLAYYHGNLRKKEKEEMLERIKNEDYDILVTSAQWLARNYEEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFTDEIIQKAWEIIRLKKQMSRYLNGNSEDRNEKLNGLNREIEKLQREIEKFKRKNKIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTKDIKEHVEELLTRLGKGGLIFVPVDQGLGYAEELANYLSEKGFKIELVSSKNKKALEKFENGEADYLIGSATYYGSLVRGIDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSEEDRRQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLRDEEVLRKLAEDPFISLVKEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEFKMVPFEELDLDEILRQIDEDREKVRLVMEGKISAKVKDLVRSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEISVGDRMLTILASGGHMFDLVTNEGYHGVLIQNEGDMLKFIPVYDTLKRCRDCGHQFVDWEKKGVCPRCGSTNVRDALENVIAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRIEFHEVTRPAIMKAIQEARDVNENRVNAQIVRRIEDRWIGFELSQELQRVFESYNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTIELGKDGKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTLVSLADGRIMEIKDAVEKSEGNLLSVNGLKPKEAKALKFWEIDWNGPLKVIKLKNGHEIKATPDHGLLVMREGKLGWVSAKNVREGDYVAFAYNTGHRGRDEYTLLKLMIKLGITDVMVELDEEYFNEKVAPIVRERISTSTKYKYLRRRVLPLYLLQEWGLDDYEAHVKSLYRQRAGSKPIPNFKLDGRFWYVFGLVLGDGTLRDSKVLISQTPLKDVKSVLEDVFPFLRVFETTNQVGFSNSIIAEVFRRLGARKGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNDRKGPNFRGILTSKRGDVLRMLSVYLYQIGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYLRIRRAQFDEAYSVYRASRRAFEGDLLPVAPVFGKLKFKNGTKNRILKETGIDVWNWLKRPEGEIPRDKLSKVLEYAEESPEKEFLKSLVEAGVTWVKVKGVEEELYTGKLYDFTTTTENFLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPRPWGEEGAHEAIRPTRPIDTGRLMQLIRDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKAELEGYVEIIEDGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVETLMRRGYVVETKGRKKLLPTEKGIKVYHYLVSKYRDLVSEERTRELEEIMDRIEEGIEDYIKVLGELYSEIQRYVSG
(845) Reverse gyrase [Methanocaldococcus infernus ME]
6
MPVPMIFKEMCPNCGGEISSERLTIGVCENCLPEDIRLEKLELCKKIEVKNLKNYCKVWREFKEFEDFVKSLGYKLLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGVLISLYLASKGKRCYIILPTTLLVKQTYERITKIIEEKNLKINVVAYHSELKNREKREAKEKIENNEFDILITTSSYLTKNMPKAKFDFIFVDDVDALLKSSKNIDRTLMLLGFSEEHINLASKIVFLIRIGKFEDAMKLREELKEKIKDVKHGCLVIASATGKSYGDRVKLYRELLNFEVGFGMNKLRDVTDLYDDKLSVEEIVRYVKKLGDGGLIFVSMDYGVEKAKEIEERLLEEGVKAKLIHSKDKKGFEDFKEGKLEVLIGVASYYGVLVRGLDMPERVRYSLFYGIPKFKIKLREYVRKLVEEGKLKEEIEIEGKSLEEIENIVREKLKIRNFSLREEDDIYLLLPDVKTYIQASGRTSRMTEFGLTKGLSIVLSDDKKLLEYLSKYMIFMYESEFKHVSEVNLEEIIKEIDEDRERLRREKRKKEVPDLLKSVLMVVESPNKARTIASFFGKPSVRKINNRNIYEVCVGDLNLIITASGGHVFDLVTKEGFYGVKIEDNLYIPIYCSIKKVDGEQFTDQKDIEELIKENVNFMDSKENIEIIREIADEVDAIFIATDIDTEGEKIGYDIALNVMPFNNSIYRVGFNEITKRAILRAVEAFKNKEKLELDENKVKGQVVRRIEDRWIGFRLSQKLWEVFGKNYLSAGRVQTPVLGWIIERYNEHREKVNLLSLRLEEDIYVSKVFDGEFDREEVNIEVKIYERKIEPQPPFTTDTLLEEATKRFNLSVDEVMSIAQDLFELGLCTYHRTSSTRVSLDGMRVAKEYLKLNGLEDYLKNREFFMEGAHECIRPTKPMDTEELIEFIKENNIRLTKNHIKVYDLIFRRFMASQMKEVLVEYEEIYIKELDEKIEGYIEVKFDGWSKLYWLKLKKLPRVEKDKLKVLEKSVRRIPKVPLYDEGEVVKLMKERKIGRPSTYAQIIKKLLDRGYVIKSKDKGKLVPTKLGIEVYNYLITNYPELISEKRTRELEEIMDKIENGEIDYIEVLNELYKEILSIT
(1773) DNA topoisomerase 1 [Methanocaldococcus infernus ME]
3
MILIIAEKPSVAKKIANALGKAKKKKIYDVPYYEVDYNGKKIVVASAVGHLFTLVEKNKSFSYPTFEIKWAPAYIEKGKSYVKNYIRALKELSKYADEIYIATDYDIEGELIGYHALKFCCGRDKGKRMKFSSLTKREIIKAFENPISMDYGLVDAGESRHIVDWYFGINLSRALMHAVKALNDWKILSIGRVQGPTLYFLAEREKEIKEFKPKPYWILEAYLKNLKAIHEKEKFWDEEEAKKIYEKVKDAKYGEVVKVERRVSKIKPPVPFDLGTLQREAYNYFKFSPKKTQEIAQSLYEKGLCLHPDTLILLPDGVKKIKELKEEGEVLCLNHNLKLTKSRYKLLKRTVREKLIKITLNDGTELITTREHPILVYRDKLLFVPSERLKEKEQIITLGHQNKELSLDNYLINEDLKRISEGDVYISKIKKIEEIEYEGEVYDLVVDKFHNFIANGIVVHNCSYPRTSSQKLPKDWSYLENILKTLKNSEYWKFAERIIEEKRKPIEGKKDDPAHPAIHVVDYPKNKEELSKEELKVYDLIARRTLSAFWDEVEREHINAKISINDELFKASGSKTVKEGWHVIYHFPTFEELNLNLKEGEKVKVEKIKLVKKETKPPKRYTLSSIIKELEKRNLGTKATRAEIVDKLIKRGYIKVSKNGSLEVTDLGASIVEVFKRFCPEIVDEKLTRELEDKLENIQMKKINKDLVLEEAKKRLIEVLKKFKEKEVEIGKNLTNKEVVGTCPRCGSPLVVKEGKYGKFIGCTNFPKCKFTKSLE
(461) DNA topoisomerase 1 [Methanocaldococcus jannaschii DSM 2661]
3
MAEIMTALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKENKEFGFYPVFDIKWVPASVDKGKEYVNKYIKALKKLSKDADEFYIATDWDIEGELIGYHALKYCCGREKAKRMRFSSLTKKEIVRAFENPDEIDYGLVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFIPKPYWVIEALLKDNLKAIHEKEKFWNEKEAKNVYEKIKDEKSAKVVEIKKTKRKLKPLPPFDLGTLQREAYSYFKISPKETQEIAQKLYENALISYPRTSSQKLPKDRKYLEDILNIIKNHPVYGKWAERILKENLKPVEGKKEDPAHPAIHIVDIPKEELSEKEKEIYDLIARRTLAAFWDNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDEIELPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKRGLGTKATRAEIIDKLIKRGYVIDDGSLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVLDEAEKRLRKILEEFKKKEEDIGIYLIKNLDATNKKAKIVGKCPKCGGDLILIRHKKGRFVGCSNYPECDVKYSLPDKGRIKIPNKVCDACKSPILKIGDREICINPECPLKQVEVKEEDRICPKCGAKLILKKGVYGAFYGCSNYPKCKYTEPINKKEVVGKCPKCGGDLVVREGKFGKFVGCSNYPKCRYTEKLKLNEKEEK
(909) Reverse gyrase [Methanocaldococcus jannaschii DSM 2661]
6
MIPMIYKEMCPNCNGEITSERLAIGVCEKCLKEENVFEKLKLCEKLREEKTLKNLKDYCIIWNEFKEFEEFVKDLGFELLSIQKMWAKRVLKNKSFSIVVPTGVGKSFFGILMSLFLAKKGKRCYIILPTTLLVKQTYEKISSLTEKNNLNIRVVAYHSELSTKEKKEVKERIENNDYDVLITTSNYLTKNMPKCKFDFVFVDDVDALLKASKNIDRTLKLLGFDEEIINEAYKIIYLIKIGKIEDAMKKREILKKKISKIKHGCLIIASATGKSYGDRVKLYRELLDFEIGFGMNKLRDVVDIYDEEFSKEKILEYIKLFGSGGIVFVSIDYGVEKAQEIEKYLLENNIKAKLIHSKDKKGFDDFREGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRLKEYINSLKEKGELKEDINIEGKTEEEIRQIITEKLKIKNFSLRKEDDEYLLLIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDEKEIFEALKKYMLFMYESEFKRIDEVNLEELIKKIDEDREKIKVGRAKGKVPDLLKSVLMVVESPNKARTIANFFGKPSVRKINNRNVYEVCIGDLNLIITASGGHVFDLVTKEGFYGVKIENNLYIPIYTSIKKVNGEQFTDQKDLEELIKQLMEKGERVNAMDAKENIEIIREIADEVDAIFIATDIDTEGEKIGYDIAINALPFNRNIYRVGFNEITKRAILKAVESFKKGEELSLDENKVKGQVVRRIEDRWIGFRLSQKLWEVFNKNYLSAGRVQTPVLGWIIERYNEHKIKVPYLSLKLENDIYIGKIWEDEFDKDEVEVEVKVYEKEIPPLPPFTTDTLLEEATKRFGLSTDEIMSIAQELFELGLCLTPDTYVVLGDGRIETIEDIVNAKERNVLSLDLDNLSIKIDTAIKFWKLRYNGNLSKITLSNNYELKATPDHCLLVLRDNQLKWIPAKDIKENDYIAMPFNYKVERKPISLLNLLKYLDITDVLIEFDENSTIFEKIAEYIRNNIKTSTKYKYLRNRRVPLKYLIEWNFDLDEIEKEAKYIYKSVAGTKKIPLFKLDERFWYFAGLVLGDGSIQDSKIRIAQTPLKDVKSILDETFPFLHNWISGNQVIISNPIIAEILEKLGMRNGKLNGIIFSLPESYINALIAGYFDTDGCFSLLYDKKAKKHNLRMVLTSKRRDVLEKIGIYLNSIGILNTLHKSREVYSLIISNKSLETFKEKIAKYLKIRKEAFINGYKTYKKEHEERFECDLLPVKEVFKKLTFEKGRKEILKDSKIHIENWYKEKTNNIPREKLKTVLRYANNSEHKEFLEKIVNGDISFVRVKKVENIPYDGYVYDLSIKHNQNFISNGVISHNCTYHRTSSTRVSLDGMRVAREYLKLNNLEDYLKNREYFMEGAHECIRPTKPMNTDELIEFLKENNIKLTKNHIKVYDLIFRRFIASQMKEAVVEYEEIYIKDLDEKVEGYVDIKFDGWSRIYNLKLKKLPRIEKSSLKVLDKKLRKIPKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVVKSKDKNKLIPTKLGIEVYNYLINNYPHLISEERTRELEEIMDKIENGEVDYIEVLKALHEEILSIR
(1047) Reverse gyrase [Methanothermococcus okinawensis IH1]
6
MIPIIYKEMCPNCNGEITSERLEIGVCERCLKEEKVFEKLELCKKLREEHTLNNLKNYCNTWKEFKEFNKFTKSLGYELLSLQKMWAKRILKNKSFSIVAPTGVGKSFFGILISLFLAKKGKKCYIILPTTILVRQNYEKILSLIENKLNINIIAYHSELSAKEKKKAKENIKNNNYDLLITTSNFLVKNIPNTAFDFIFVDDVDALLKASNNIDKTLKLLGFNEDIINEAYDIIRLIKIGRLNDALKKRKTLKNKISKIKHGCLVIASATGKSYGRKVKLYREILDFEIGFGMNKLRDVIDAYDEEFSKEKILEYIKLLGKGGIVYVSKDYGIEKAQEIEKFLLKKGINAKLIHSKDKKGFDEFKNGNIGVLIGMASYYGILVRGLDMPERVRYALFYGIPKFKIKLKEYIDDLKNKGKLKEDVDIEGKTKEEIKQILIEKLKIKNFSLRKDNNNNEYNLLIPDIKTYIQASGRTSRMTEFGLTKGVSIVLVDEKEIFEYLEKYMLFAYESEFTSIDNIDIKELIKKIDKIREKIKLGRAQGGVPDLLKSILMVVESPNKARTIANFFGKPSIRRMNNRNIYEVCVGDLNLIITASGGHVFDLVTKEGFYGVIINNISIPIYSSIKKVNGKQFIDQKDLEELLSVKKVEETNIMDSKDNIYIIREIADEVDAIFIATDIDTEGEKIGYDIFLNVLPFNKNIYRVGFNEITKRAILNALESFKKGDKLNLNENKVKGQIVRRVEDRWIGFRLSQKLWEVFNKHYLSAGRIQTPVLGWIIDRYNEHKIKVPYLSLKLENDIFIGKVWEKEFDKKEVKVEVKVYEKEFHPLPPFTTDTLLEEATKRFKISSDEVMNISQELFELGLSTYHRTSSTRVSFDGMRVAREYLKLNNLEDYLKNREYFMEGAHECIRPTKPMDTYELIEYLKENNIKLSKNHIKIYDLIFRRFIASQMKKAVVEYEEIYIKDLDEKIEGYIDIKFEGWSNIYNLRLKKLPKIEKNSLKILDKKVKKIPKVPLYNEGDIVKLMKEKCIGRPSTYATIIKKLLDKGYIIKSRAENKLIPTKLGIEVYDYLITNYFSLISEERTRALEETMDKIENGKVDYLEVLKELHNEILCIN
(1878) DNA topoisomerase 1 [Methanothermococcus okinawensis IH1]
3
MTDLIICEKPNVAKKIASALGNPKKKSNNGIPYYELERNGKKIIVASAVGHLFTLEEEKTGEKKKFGEYPVFNIKWVPASTIKGKEYVQKYINTLKKLAKEADEFYIASDWDIEGELIGYHALYYCCGKNDAKRMRFSSLTKNEIIKAYENPDRVDFGLVDAGDSRHRVDWYYGINVSRALMQSIRAVNRWQTMSTGRVQGPALSFLVDRELEIKKFVPKPYWVIGAHLKNELLAIHEKDKFWDEKEANEIYNRIKDEKEAIISSIKKTKKKIKPNPPFDLGTLQREAHRIFRFSPKKTQEIAQKLYEMGICSYPRTSSQKLPKDDNYIKDILTKVSNHGDYKKYAELILRENRKPIEGKKSDPAHPAIHVVDVPKELLNDDEKKLYDLIVRRTLAAFWDNAEREYINVVLNIDGENFKLSGSRTIKEGWHEIYYFTKFDEKELPSLRKNDKIPVEKITIERKETKPPKRYTMASIIKELESRELGTKATRADIVEKLVKRGYLIDDGSLKVTDLGIAVIETLKKYCPEIIDEKMTRELEKKLDRLQKRTIKKENVLKDAENKLRAILEEVKKKEKEIGKELVEKIDTTNKSLKTVGKCECGGDLIIIKTKGKKRFIGCTNYPECKKTYPLPQKGRIKILNETCEICGAPIISIDNQKVCINPECPSKISNEDKKEMEKAEKSEKICPKCGGKLVVKKGIYGAFLGCENYPKCRYTEKLNNKTKTEKAEKVVVGKCPECGGDLIMRKGRFGEFIGCSNYPKCRYTEKIKNEKTKTKKEKK
(1520) DNA topoisomerase 1 [Methanococcus aeolicus Nankai-3]
3
MTDLIICEKPNVSKKIADALGKPKKKSNDGVPYYEIERNGKKIIVASAVGHLYTLEEKKSDEKGKNKGRNSFGRYPIFDIRWVPASTIKGKEYVQKYINTLNKLSKKSNDYYIASDWDIEGELIGYHALRYCCNEDNAKRMRFSSLTKKDIIKAYEQPDNIDFGLVDAGDTRHRLDWYYGINMSVALMQCIRSVNRWHTMSTGRVQGPALSFLVDRELEIRKFVPVPYWVIDANLKDGLIAIHEKDKFWDEKEANTIYNKIKDEKEAIVANVKKTKKTIKPNPPFDLGALQREAHRIFKFSPKKTQEIAQKLYEKAICSYPRTSSQKLPKDDNYINDILNKVVNHNIYGKYAKSIIEEGRKPIEGKKDDPAHPAIHFVDTPKEELPPEEQKLYDLIVRRTLAVFWDNAEREYSNISLDIGGEIFKLSGSRTIKEGWHEIYYFTKFDETELPALRKNNKIVVEKINIEEKETKPPKRYTMSSIIKELENRELGTKSTRADIVEKLVKRGYLIEDNSLTVTDLGIGVIEVLKKYCPEIIDEQMTRELEKKLDRLQKRTIKKETVLKDAEKKLTAILNEVKKKEKEIGAELVEKVDATNKTLQTIGKCECGGDLGIIRIKNKRRFVGCSNYPECTIAYPLPAKGRIKIPNEVCEVCGKPMLLIDNQKLCVNTDCPSKISEEDKKELEKLEKSEKPCPKCDGTLTVKKGVYGVFLGCSNYPKCKYTEKLHSKKEDSEITVVGECPDCGGDLVIKKGRFGEFIACSNYPKCKHTEKIKKDGKSNAKATKTEKTETKTTKKKSTKGSTTKEKKKPDNSNEVGECPDCGGDLVIKKGRFGEFIACSNYPKCKHTEKIKKD
(1854) DNA topoisomerase 1 [Methanococcus maripaludis X1]
3
MTGLIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKTKTKFGDYPVYDINWVPASTLDEKKYIQKYIDALKKVSKDANKFYVATDWDIEGELIGYHALNFSCGQKNAHRLRFSSLTKKEILKAYENPNEIDFGLVDAGDSRHKIDWYFGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALLDNDLIAVHELEKFWDEEQANKAYEKVKGQKQATVSDVKKSMKTIPPNPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEKGYCSYPRTSSQKLPDDKAYMDEVLKNLSKNKNYKPYIETILNENRKPISGKKDDPAHPAVHAVDVPKEKLPDDELKLYELIARRTIALYWDNAKREYSKINLDINGETFKLSGSRTVEEGWHEIYYYTKFDEVELPELKKNDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYVIEDGSLTVTDLGIGVTETLRKYCPEIVEETLTRDLEDKLELIQDKKIKKEEVIQETKDKLTKILGEFRLKEKEIGTELVDKLDSTNRSLQIIGKCKCGGDMIIIRTKGKKRFVGCSNYPDCEVTFPLPQKGRIKVLNEVCEKCQNPVIGLDRIKICVNPDCSTRISEEDKKEIEKAEKEEKICPKCGNKLLIKKGPYGVFRGCENYPKCKYTEKLNGESNEKEIVGKCPKCGSDLYKRKGRFGEFIGCSNYPKCRHTEKIDKKKEDTPGETKAETKKEAKPKTTKKAAPKKTATKTTKTTAKKTATKKTTTKKATAKKTAEK
(663) DNA topoisomerase I [Methanocella arvoryzae MRE50]
3
MHLIITEKHDAASKIAAILFKDRTPERINGVPAYRSKAADALVIGLAGHILELDFPEAYQKWSAFPPRELIRAQVVTYPSKKDLVGALATLATKVTRVTIATDYDREGEMIGVEAYNIIKKISSPTFDRVRYSSFTKEEITKAFASPTAVDFDLAAAGECRQEIDLVWGAALTRFVSIAGNKFGKDFLSVGRVQTPLLALIVDREKEIQAFTSKPYWEIVATLLKEDRSFTASHKRGRFDKKEEAAAIHKKLGKTAVVKDVKADRKKEQPPIPFNTTEFVKAASALGFTAASAMQIAEALYINGWISYPRTDNTVYPDTLNLKDLLGIFKTSPDFAKSALELLAMPSITPTRGKVETKDHPPIYPVACAMRKDLDDRQWKLYELVVRRYFATLSPACEWETIKAEIDISGEPFAANGKQLAVPGWRKHYPYGLQKDELLPPLKAGDPLLVRKADLLEKKTEPPKRYGQGKLVQMMEDLGLGTKATRHEALAKLYQRGFIEGNPPQPTATGISLIDALKAYASAITSNAMTSKLERDMDAIAASQLKKAAVAKESREMLDKVFDQLEKNRLEIGRILRSGFAADSDIGPCPLCGSALVVRERKSDKNKFIACSGFPNCRNTYNVPPGTLKFDKTVCEKHRLHHVKVTPPSTKGPDGKAVRGKAYDFGCPACRKENPSVMPPCVKTCKPDLRAMIPHGRESGELVTTEAHRVTGLPQRHRDAQRFTEIFTIIIMMLTLRLQLLFFCPSRYPITSPVTIPVPLQQGSGRG
(788) DNA topoisomerase 1 [Methanocella arvoryzae MRE50]
3
MHLIITEKNITAKKIAQILFGKGTKETKVEGVSVYSSGDTSIVGLSGHIVNIDFPEQYNNWSVTAPKDLIRAETEMRYTHKKIATALKKLSKDATSVTIATDYDREGELIGVEAYRIISGFKPDIKFDRAKFSAITKPEIDRAFSNRVPLDFNLAAAGEARQKIDLVWGAALTRYISLTCGRLGKSFLSVGRVQTPLLALLVDREKEIKAFVSTPYWEIYATLGNGTDFTAKHECNRFEDKKKADSVRAKLGSTGTVVEYKKDARSDAAPIPFSTTEFIRAASSIGFSAANAMRIAENLYVNGWISYPRTDNTVYPSSLNLRDVLQNFAAGEFGEYARKLLAMKTLVPTRGKKETTDHPPIYPVSSAKKSDMADDEWRVYELVVRRFFATLAPAATWETRNTTVDISGEKFKASGSKLTEAGWRYYYPYGMPKEEVLPALEVGETLKVKKIEMPEKMTQPPTRYGQGRLVKMMEDLGLGTKSTRHEAIQKLYARNYVHGNPPQPTNTAIAVVDALERYADLITKPDMTSKLEQDMDLIADGKIKEDAVVDESQNMLETIFGVLDKNHDEIREVLFDGLREDKILGKCQTCGSDLMVRKSKKGGRFIGCTGYPNCTFSLPLPPSGTIVATNKVCERHGLSHIKITTGGKKPWELGCPQCNFEEWQKKKKEAAAAPGEATTGTATAPKKSAPKKVMAKTGGSDENTAEPKKPAARKAAPKKKVIEKAPEA
(718) DNA topoisomerase 1 [Methanosaeta harundinacea 6Ac]
3
MHLIIAEKHNVAKRIAQILAGSKPKVKRVHGIEAFYFDDKVVMGLSGHIVGVDYPPGYNNWQKVDYRDLIHAEVVTRPTQGKIVSALHDLGKDADRITIATDYDREGELIGVEALRIAEDANPTIKADRVRFSAITKGEIQDAFESPGEVDFDLASSGEARQVVDLIWGAALTRFISITSGRLGKGFLSVGRVQSPTLALIVDREKEIEAFKPQPYWEISACLEKDLRVKHEKGRIWEGDLARSIFEELGEVATVVSIKEKTRTDRPPAPFDTTAFISAASGIGFSAANAMRIAEWLYTSGFISYPRTENTVYPKTLDLRALVSIFKKGPFREDAERVLSGPMVPTRGKRFSTDHPPIYPTAPAAKADMKPDQWKIYELVVRRFLATLSGPSRWIVMNVRVEIDGQPFRATGARQIEAGWRACYPYSKAAEEILPQLSEGEKLRVLGKELEEKETQPPSRYGQGRLVKLMDELGLGTKSTRHEIISKLYARAYVQGNPMKPTNTAYAVVEALQQHSPNITKPDMTRTLEEDMTKIANGHVGEEAVIEESRSMLDAVFDDLLRHQEEIGTTLREGLRTDKIVGLCQICGHELIIRRGRRGSRFIGCAGYPDCTFTLPLPKFGMIVVTDKACEEHGMQQIRIINKGKRPWDLGCPKCNFDQWQAKKAEEAKKKTEVDLLAKIPGIGPKTLEKLGAAGVKTALDLAGAEAEALAEKTGLTKKKISSWQLLAKTMVNEAQSC
(356) DNA topoisomerase 1 [Haloarcula marismortui ATCC 43049]
3
MRLIITEKDNAARRIAEILSEGGASANRRNGVNVYRWGNTRVVGLSGHVVGVDFPEEYNDWRDVEPVELIDADVTKEPTQENIVTTLKQLAREADEATIATDYDREGELIGKEAYELIREETDAPVDRVRFSSITEREVRDAFANPDDIDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGDDFISVGRVQSPTLKLIVDREREIQAFDPEDYWEIFADLQKNGSGFEAQYFYDDDGKEAERVWVEDDADDAYADLTNVDAATVTSVRRRTRTDSPPTPFNTTAFISAASSLGYSAQQAMSIAEELYTTGYITYPRTDNTVYPDDLEEDALLDEFVGAGHFGEDAEALLEQDDITATEGDEETTDHPPIHPTGEIPPKADLSDDEWEIYELVVRRFFATVAEAATWEHLRVVADAGGRSLKANGKRLVEPGYHEVYPYSSASENHVPDVEEGEELAISEVRMEAKQTQPPRRYGQSRLIQTMEDKGLGTKCLTADSDVLVRSENGDIERQTVDSLFSDGQVVLADGDTDIAVSKETPTVLSLDEATERVSEQESTLVSERPLRDDESVRTIETSRGAVTVTDDHPMYIRQDGEVTVRPASDIEAGTDLVAARRPPDTMVEPSDETVLSWETFAADCDKHSKLYGVDCGTELAAQRAARDESQTAFAERYGSYGSAVGKYERGEKDVPVWLLGELDIRPDRIHGLNYETSFENPFPLEWSPELAQVIGCLLGDGSIHRNDDENVVDVRYHNTDEALIERFARDIERLFDIEPTVTDRPGRESHHKRKYQVDVPSAVGRVLVCVLEAVTENGTPGLPDAVRPAFVGALFDDEGHISREGKAFISNTDHTLLTGVGEMLAEMGIETKLAPDQHKLHIRGRRNLEQFLDRIPIASDEKFYRGLDALDAYDVTTRKAELLEAIRQEPKTSAALAQTLGVTRGSVNKYLRELRESGHIEKQIEGSNRSLDENRTVQYVAADFEGSVYATLRGEPSSVTVEDVERREYDGPVYDLTVSENAPNFAVNGGAVVHNSTRHNSIEKLYDRGYIEGDPPRPTTLAMAVVEAAEEFADHVVSDEMTAQLEADMTAIANGEATLDDVADESREMLKRVFDELRDSREEIGEHLQESLKADKTLGPCPKCGEDMLVRRSRQGSYFVGCDGFPECRNTLPLPSTGEPQVLEDHCEEHDMHHVKMLAGRDTFVHGCPRCEAEKADESEDEVIGPCPECGSEHDGDLAIKHLRSGSRLVGCTRYPDCDYSLPLPRNGDISVTEAFCEEHDLPELVIDADSDDPWELGCPICNYEEYQARTAIEDLEDLNGIGSATAEKLGDAGVDSLAALREADPDIVATEVQGVSATQVRDWQDELEA
(660) DNA topoisomerase 1 [Haloarcula hispanica ATCC 33960]
3
MRLIITEKDNAARRIAEILSEGSASASRQNGVNVYRWGNTRVVGLSGHVVGVDFPEEYNDWRDVEPVELIDADVTKEPTQENIVTTLKQLAREADEATIATDYDREGELIGKEAYELIREETDAPVDRVRFSSITEREVRDAFANPDDIDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGDDFISVGRVQSPTLKLIVDREREIQAFDPEDYWEIFADLQKNGSGFEAQYFYDDDGKEAERVWVEDDADDAYADLTGVNAATVTSVRRRTRTDSPPTPFNTTAFISAASSLGYSAQQAMSIAEELYTTGYITYPRTDNTVYPDDLEEDALLDEFVGAGHFGEDAEKLLEQDDITATEGDEETTDHPPIHPTGEIPPKVDLSDDEWEIYELVVRRFFATVAEAATWEHLRVVADAGGRSLKANGKRLVEPGYHEVYPYSSASENHVPDVEEGEELAISEVRMEAKQTQPPRRYGQSRLIQTMEDKGLGTKSTRHNSIEKLYDRGYIEGDPPRPTTLAMAVVEAAEEFADHVVSDEMTAQLEADMTAIANGEATLDDVADESREMLKRVFDELRDSREEIGEHLQESLKADKTLGPCPKCGEDMLVRRSRQGSYFVGCDGFPECRNTLPLPSTGEPQVLEEHCEEHDMYHVKMLAGRDTFVHGCPRCEAEKADESEDEVIGPCPECGVAPAEQRGDGGEAAEAEGGELAIKHLRSGSRLVGCTRYPDCDYSLPLPRNGDISVTEAYCEEHDLPELVIDADSDDPWELGCPICNYEEYQARTAVEDLEDLNGIGSATAEKLGDAGVDSLAALREADPDIVATEVQGVSATQVREWQDELEA
(13) DNA topoisomerase 1 [Halalkalicoccus jeotgali B3]
3
MDLIITEKDNAARRIAAILSGESAEVERQNGVNVYRWGGKRCIGLSGHVVAVDFPSEYSDWRDVEPVELIGAAVEKTPTQENIVRTVRLLARDANRVTIATDYDREGELIGKEAYEIVRDVNDGAEIDRVRFSSITDGEVHSAFDDPDEIDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGDDFISVGRVQTPTLKLIVDREREIEAFDPEAYWEIFANLVKGEESFDAQYFYRDEDGNEAERVWDGQRAEAVYETLREASEARVESVSRRTRTDAPPAPFNTTQFIRAASSIGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPEDLDPRELLDAFTGNRTFGEDAETLLEREEITPTEGDEETTDHPPIHPTEELPTKGELSDAEWEVYELVVRRFFATVADSARWEHLKVVLEVGEHRLKANGKRLVEPGYHAVYPYFSTNENVVPDVEEGESLALTEIRIEDKETQPPRRYGQSRLIETMEEMGIGTKSTRHNTIEKLYDRGYIENDSPRPTKLATAVVEAGEEYADRVVSEAMTAQLEDDMQAIAAGEKDLDEVAGESREMLERVFDDLMESREEIGDHLQKSLKADKTLGPCPESGHDLLVRRSRRGSYFVGCDGYPDCEYTLPLPNTGKPLILEATCEEHDLRHVKMLAGRGTFVHGCPQCKADEADEEEDRVIGACPECGEGSIPPSSRDGEDPAATAEDGQPVEADGGELAIKQLRNGSRLVGCTRYPDCDYSLPLPRRGDIEITDERCEEHGLPELLVHSGDEPWELGCPICNYREYQERENDSGTDLESIEGVGAKTAEKLAAAGVESVSDLQDAEAETVANEVEGISADRVRKWQAKAG
(14) DNA topoisomerase 1 [Halalkalicoccus jeotgali B3]
3
MDLIITEKDNAARRIAAILSGESAEVERQNGVNVYRWGGKRCIGLSGHVVAVDFPSEYSDWRDVEPVELIGAAVEKTPTQENIVRTVRLLARDANRVTIATDYDREGELIGKEAYEIVRDVNDGAEIDRVRFSSITDGEVHSAFDDPDEIDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGDDFISVGRVQTPTLKLIVDREREIEAFDPEAYWEIFANLVKGEESFDAQYFYRDEDGNEAERVWDGQRAEAVYETLREASEARVESVSRRTRTDAPPAPFNTTQFIRAASSIGYSAKRAMSIAEDLYTAGYITYPRTDNTVYPEDLDPRELLDAFTGNRTFGEDAETLLEREEITPTEGDEETTDHPPIHPTEELPTKGELSDAEWEVYELVVRRFFATVADSARWEHLKVVLEVGEHRLKANGKRLVEPGYHAVYPYFSTNENVVPDVEEGESLALTEIRIEDKETQPPRRYGQSRLIETMEEMGIGTKSTRHNTIEKLYDRGYIENDSPRPTKLATAVVEAGEEYADRVVSEAMTAQLEDDMQAIAAGEKDLDEVAGESREMLERVFDDLMESREEIGDHLQKSLKADKTLGPCPESGHDLLVRRSRRGSYFVGCDGYPDCEYTLPLPNTGKPLILEATCEEHDLRHVKMLAGRGTFVHGCPQCKADEADEEEDRVIGACPECGEGSIPPSSRDGEDPAATAEDGQPVEADGGELAIKQLRNGSRLVGCTRYPDCDYSLPLPRRGDIEITDERCEEHGLPELLVHSGDEPWELGCPICNYREYQERENDSGTDLESIEGVGAKTAEKLAAAGVESVSDLQDAEAETVANEVEGISADRVRKWQAKAG
(472) DNA topoisomerase 1 [Methanoculleus marisnigri JR1]
3
MHLIIAEKNISANRIAQILAGNEKVRATKDGSVSTYSFDTKTVVGLKGHVVEVDFEPGYTNWRSETHTPRTLIDAGIVKKPTEKKIVNLIQKLSRKADLVTIATDYDTEGELIGKEAYELVRAVNPNVRINRARFSAITPAEIRTAFENLTDLDFDLAAAGEARQTVDLMWGASLTRFISLAARRGGTNILSVGRVQSPTLAMIVEREREIESFVPQTYWMLSLATEKDGVTIEARHTAGRFTDHEAALAAEAGTKEPLVVTDVKEGQKNDRAPTPFDTTTFIVAASRLGLSAANAMRLAEDLYMNGYISYPRTDNTVYPKSLNLNAILNTLKGGVFDKDVAWVQQNRRPVPTRGKKESTDHPPIHPTGSATREALGQDRWKVYELVVRRFLATLSPDANWATTRCTFDASGEAYKATGGRLLYAGWRRIYPYSEAKENILPVLAPGERLPIKNVNLEEKETQPPARYSQSRLIQVMEELGLGTKSTRHEVIGKLVSRRYVEGNPLRPTLVGRAVIDALDNHAETITEPEMTQTLEEHMQLIKQSQRSRDDVVTESREMLHRVFDKLEAHKSEIGTEIMEQTAEEHTVGPCPDCGHDLRIRHIGVSQFIGCTGYPECRFNISLPGSTWGKAIRVEATCPEHNLSHVRLIRKGARPWDIGCPLCSHITSNVEALRMMPSMTDDLMQRLHAQHIYTVSEIAGMQPEDLAKAVDVGTKEAVELAREAEDALEVLRRRSELRKFVRKIVPPRRGRSHAKIIKNLLGQGIGDIHALSVAEPAALKKAGIPEAAGAELLEAARGLCNERALREAGVPAVSLKKYQAGGVATLDDFCYLPIPYLASKTGINPETVHKHVDLVCRHLGRPAPQKISRTVFERGRKELLEVPGLGEATVDRLYLAGIYDAATLRVADPEEVSSVTGIPKARLRDYIGHLK
(685) DNA topoisomerase, type IA, central domain protein [Methanocorpusculum labreanum Z]
3
MHLIIAEKNIVAERIAAFLAGKAKVQVTRDGAAAHYVFDDTVVMGLRGHVVEVDFVEGYNNWRSVEHPPRSLINADIVKKPTEKKIVGLMQKFGKKATRVTIATDYDTEGELIGKEAFELIRAANPKVPIDRARFSAITKDEIVKSIKEATSLDFNLASAGESRQIIDLVWGASLTRFLSITAHRGADSILSVGRVQSPTLAMIVDREREIEAFVPTKYWMLSLATEKSGIGVEARHVHGRFTDSAEAKAAYDATVEPLRVTDVITGHKVDRAPTPLDTTALIVGASRLGISASYAMNRAEDLYMRGFISYPRTDNTAYPKSLKISEQLAIFAHGAFSKEAGYVKDHLRSVPTRGKKETTDHPPIYPTSLANREEIGDDVSWKLYEFIVRRFFATICIDAEWETMKVNLLAGSEPYTITGGRILEAGWRGIYPYSKAEENLLPAFTLGETLPLLAKTSDEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVISKLSGRKYIEGNPMKPTIVGRAVTESLEEFAGTITEPTMTKTLEEHMGDIAAGTKTINAVLSESRKMLTGIFDDLEKNEAAIGRDLMERTREEQTIGPCPVCGKPLRIKRVGSSQFIGCSGYPDCTFNTGLPPATWGNAIKMDEVCGIHGLNHVQLLRKGAPAWKIGCPLCSHIKSNTESFLLMPGMTAEGVQKLNAVHIYTLSELISRGPEELSKSLGLSKSEAEKLIREAGSVLALLKKRTELKKFVSSHVAPKRGRGHSKVSAALISLGVVDVEALSRADPKDLLETKLSEAEAASLVAEAKSMVNISRMKEYGVPAITLKKYVNAGFDDPEKFISVHPAGLSLATGVSVTTICNHQKLVAEKLCRPCPEKISKAAFEEGIAPLRKKAEPELLTPLALAGVYSPDLLVKADAKTLAKVTGIDEKQIVNLQKYAQKVLEK
(891) DNA topoisomerase [Methanosarcina mazei Go1]
3
MTVVAFAEKNKAAAQIASILGEGEVDKISVEGLPAYEFKWKGEEWLVMGLSGHIMNYDFPEKYNKWSEVDPGTLLGVDPEKFVTRKEYEAAIKNLAKRADKIILACDYDREGENIGFEAKTLAEEVTDVPVARARFSALSPKEVRKAFENPVDPDHNLAMAAEARQILDLKMGAAFTRFVTLSVREKARTKDVLSIGPCQTPTCGFVYEREKAIRAFEAKDFWKITAVFAAKGGEFEGTHRAGNIHDKEKAAEIFKRLKGAKEGLVVKKTVKEAKTSPPNPLNTTEFLKRASKFLGISPEVALETAEQLYLAGFTSYPRTETNKYADDFDFKSLVFDFARQKEYKPFAESILSAPIVPKNGEKDAHDHPPIHPIRAAARGEVSSAVNIPQAAEVYDLIARHFLANLMPAAVFEKTHLHLQVKEEPFDSSGTVLKEPGWLEVYPFENKKDKLLPFVEEKERVDVKKLSNTKSKTSPPKKLTEAELLTLMDRHGIGTKATAPTHIETNKKRGYFENKGKTISILDTGFTLMEGLSLSVPILVKPDIRSKIEALIQEVEDGKKEFEAALADGTVLIKEMYAQLEANKKELTSNIAGTIKDEAALEDKKNYIGTCKACGHVLRIIQTDSGRFVGCTGYPDCRNSFSLPKTGALTVLRSKECKKEGAAVLKVGNKYNWAVGIGPCFKCEFEKECYPPETVGPCPECDGSMFLISFKDNRFLGCTKRCGYTHSVPKTGKLTLLDKTCETCGWKLFRLKEEVEGNESLEEDICINRRCTEGIKYWKKVGPRSGARAQGKISADSGAELGARSTARNKERTTARRVSKTVSVADSRKDRK
(1737) DNA topoisomerase 1 [Methanosarcina mazei Go1]
3
MHLIVTEKNIAARRIAAILAPKSPKKERVSGVDVYRYEIGSGENRQETAVVGLSGHIVGIDFPKEYNNWQKVDARDLIDAEITTTPINRKIVTALKSLGKEADRVTIATDYDREGELIGVEALNIIKKVNPKIPFDRVRYSAITPKAIEAAFSNPTNVDFNLADAGHSRQVIDLVWGAALTRYISLAAGRLGKMFLSVGRVQSPTLSLIVDREKERNIFVPTPYWEIHVELEDAAGETFSAQHSTRRFLDKEEASKVFRKLGKKAELKEIEKGTKTDQPPTPFNTTGFISAANSIGLSPANAMRIAESLYTNGYISYPRTDNTVYPDTLDLKAQIEIFKEGPFKEYANTLLEKPELVPTRGKKETTDHPPIFPASLAKESDLKEDEWKVYELVVRRFFATFAGPSIWETMRLKLDIEGEEFRANGARLLEPGWRWYYPYNAPEDRLLPELKESDLLKVIKKEMLDKETQPPGRYGQGRLINIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVMDTLEKYSPTITKPDMTKLLEENMDKIAEGKIKEEAVLEESREMLKQVFSELDKNRDNIIESLQAGLREDKIIGDCSLCGNELMIRRSKRGSRFIGCSNYPNCTFSLPLPKSGQIIVTDKLCEAHGLHHIRIINQGKRAWDLGCPQCNFIEWQKTQKEEQAQQPKKEKPKSIKDLEGVGKATAGKLEEAGITSVEALAEADPVELAKTIKTSVKKIKNWQTSCNGGAVEDL
(241) DNA topoisomerase 1 [Methanohalophilus mahii DSM 5219]
3
MHLIIAEKQIAARRIASILSPKKPQKKRISGIDSYEFGNDEKTIVIGLSGHIVQLDFPPAYNNWQKVEAKELVDAELIITPTHAKIVSALKKLGKKATKVTIATDYDREGELIGVEALNIVKGVNESIEYERAVYSAITPAAIKEAFENTTKIDFNLADAGHSRQVIDLVWGASLTRFISLASRRLGKQFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYVDLSKNGEIFKIRHKNTRFWEKEEANRVFRLIGNEALVSSLETSTKEDKPPTPFNTTEFIRAANSIGFTPANAMRIAESLYTNGYISYPRTDNTVYPSTIDLREQIEMFSKGHFSEYAKKLLAKKELKPTKGKKETTDHPPIFPASVAKKAQLKEDEWKLYELVVRRFFATFAENAEWETMKVRFDINEEEFRANGSRLVKPGWRWYYPYNAPEDRLIPALEEGEILPVNDKEILDKETNPPGRYGQGRLIKMMEDMALGTKATRHEIISKLYSRAYVHGNPLQPTQTAYAVVEGLENYAPTITRPDMTSSLEEDMDRIAEGNTSEENVLQQSRDMLTDVFKELEDNREKISESLREGLRKDKIIGKCPDCGCDLIVRRSRRGSRFIGCEGYPDCTFSLPLPKSGHILVTDKTCDKHSLYHIKVKGQKKRAWDLGCPYCNYLEWKEEQKKEKAATPRPEKISDIPGIGKVTEEKLNSAGISTVDELENSDANEISKTTNIPLGKIIRWQEAVAY
(524) DNA topoisomerase [Methanohalophilus mahii DSM 5219]
3
MTIVVFAEKNKAAAKLATILSGGNSTREHVADLPVYSFVAKGDEYKIIGLAGHITSYDFDPAYRDWKAIDPAVLLTADPIKNITKKNYERAVRQLAKQADSIVLACDYDREGENIGFEARDIALQVKKVPVKRARFSSLSANEVQKAFNNLVEPDTNLALSADTRQILDLRMGAAFTRFMTLAVREEAYTKNILSIGPCQTPTCGFVYEREKTIRDFQPEDFWKIEAVFQAGSSEFEGVHRKGNIRDVELAKKIYEKLQGTREAIVFRLNIKEKQINPPYPLNTNEFLKRASKFLDISPEKALEIAEQLYLAGFISYPRTETNRYPEDHDFKSMLKNLLRIDEYAPFAENLLKTTVSPRNGKKDGHDHPPIHPIKAVSEKQIKNAVKLDNSWKVYDLIVRHFLANLMDPALFEKTHMEVHVKDEPFDCKGSVMKSEGWKQVYPFEISKEKLLPHVQEGDKVAVNKLTNTKSQTTPPKRLTEAELLTLMDKHGIGTKATAPSHIETNKKRGYFEIKGKTISMLDTGFNLMDALGVSVPILIQPEIRAKIEGLIEDVEKGIKSFDEAISEGTVLIQKMYTRLKSGKGDIVLRIAGSIKDEKLAEDKKNHIGKCDKCGRTLSIIRTDKGRFVGCSGYPQCRNTYPLPRKGSLDVMRSRECKKGGFAVLKVGGGKYYWSVGVGPCFNCEKQKLCFPPTVIGKCPTCGCDMILIETKDSKFLGCARRCGFTCSYPQKGRVTLRDETCDECGWRIVRVKEPKKDGRHYCINRKCNQKFKNLL
(37) DNA topoisomerase 1 [Methanohalobium evestigatum Z-7303]
3
MHLIIAEKHIAAKRIAAILAPKKPKKVRVSGVDTYEYEDNEDDKIVMGLSGHIVELDFPKEYNNWQKVNAEDLIDAELITKPTQVKIVAALKKLGKKASKVTIATDYDGEGELIGVEALDIIKKVNQDIQFDRVKYSAITEKEIKNAFSNPVNVDFNLADAGHSRQVIDLVWGASLTRYISLSAGRLGKMFLSVGRVQSPTLALIVDREKEREAFVPDPYWEVYATLANSNGEEFVTQHKTQRFWDKNQVNSVVDKLKDCKTAEVTSVEKSTKQDKPPSPFNTTEFISAANSVGFTASNAMRIAETLYTNGYISYPRTDNTVYPDSLDLRNLIAMFKSGQFKQYAQYLLNKSNLVPTRGKKETQDHPPIYPTSAAKKSELNEDEWKIYEMVVRRFFATFADPAKWETMKVKFDIGSEEFRAKGARLISPGWRWFYPYNSPEDKILPPLKKGEVLTVKSSKVADKETQPPGRYGQGRLVRIMEELGLGTKATRHEIISKLFSRAYVHSNPLQPTKTAFAVIDALENYAPTITKHEMTSKLEEDMEKISEGKIKEDEVLKESRDMLKSMFSELESNRDNITQSLRNGLREDKVIGTCPECESRLMVRRSKRGSRFIGCDGYPDCTFSLPLPKSGQIIVTDKVCEDHGINHIRVNIPGKRPWNLGCPHCNFIEWQKEQENNKNKQKDTTPKSITEINGIGKVTAEKLENAGVSSVEELANADAVELSKQTNLSVKKIKNWQEYVA
(1226) DNA topoisomerase [Methanohalobium evestigatum Z-7303]
3
MSIVAFAEKNKAAAQIASILSEGNFERTTLEGVNVYEFKKDGKQWRIMGLSGHIMTYDYPQEYNNWKDVDPGVLIDTMPEQFITKQAFANAISRLAKDSDEIILACDYDREGENIGFEAKSIAEKVCNSPIKRARFSSLSTGEIKKAFQNPVEPDVNLANSAKARQILDLKMGVAFTRYITLSVQQKARTKGVLSIGPCQTPTCGFVYEREKAIKEFEPRDFWKIEAVFTHNDIDFQGTHRTGKFFDKQKADAVYNKISDCKTGQVTNKKVKETKSSPPYPLNTNEFLKRASKFLGLNSDRALEIAEQLYLSGFTSYPRTETNKYANDFDFQSRVAELTKKAHKELALEVFKNSEDGFNPRNGTKDAQDHPPIHPIKSANKGDINNAVNDSKGWDVYDLIVRHFLANLMQPAVFEKTRIEISVNDEIFDATGTVKKESGWIWVYPFEAKNDKILPEIEINEKLKINKITNTNSQTTPPKRLTESELLTLMDKNGIGTKATAPTHIETNKKRGYFETKGKSISILDTGFTLMDALDKSVPLIVKPEIRARVEQLIQDVEDGKKSLDGAINEGTALIKQMYSQLTSNKDEMVSQIAGTIYDESVAADSDNYIGKCSECSRVLRIVTTDNGRFVGCTGYPECKNTYPLPKKGALNIMKSRECKKGAPAVIKVGNKYHWAVGIGPCFKCDMENECFPPEIVGQCPNCDGYMFLIKTKDSRFLGCTNKCGYTQSVPKSGRLTILDDTCECGWNIVRVKEKEKEAKEFCVNRKCINKL
(904) DNA topoisomerase 1 [Methanosalsum zhilinae DSM 4017]
3
MHLIIAEKNIAAKRIASILAPKKPKQSRVNGVDTYQFKNKEETVVIGLSGHIVTVDFPPQYKNWQKVESRELIDAEIVTVATHSKIVSVLKKMAKKATNVTIATDYDREGELIGVEALNILKKANPDLKFDRVRYSAITPKEINDAFSNPVSIDFNLAAAGHSRQVIDLVWGASLTRYLSLVSGRLGNMFLSVGRVQSPTLAIIVDREKERDEFVPKPYWEIDALLEDKNKNEVLASHSKGRFWDKDEADTVMEKVNKARKAVVSQIRKSSKTDKPPTPFNTTELISAASSIGFTASNAMRIAESLYTNGYISYPRTDNTVYPASLDLRAQIEIFSSGIFKEYANELLKKKELIPTRGKKESTDHPPIYPASYAKKSELNEQEWKLYELVVRRFFATFAEPARWETMRIKFEINEEEFKSSGARLVNAGWRWYYPYNAPEDRLLPQMEEKDILSVEKIDMVDKETKPPGRYGQGRLIRLMEELGLGTKATRHETISKLYSRTYVHGSPLIPTKTAYAVIETLEKYAPTITKPDMTSKLEQDMDKIAEGEITENDVIDESREMLQSIFSEFEKCQDKIAESLRAGLREDKIVGSCPECNSKLSIRRSRRGSRFIGCSNYPDCTFSLPLPKSGQIIVTDKSCDEHGLYHLRIISKGRRPWNLGCPQCNFLEWQKSQNNENQEKNEKVTSKNAHKKTVPASKKKSDKVTEISGIGKVTAEKLDEAGIVKIGDLLNADATEISRKTNISVKKIKNWQKIAVPDRQN
(1670) DNA topoisomerase [Methanosalsum zhilinae DSM 4017]
3
MTTVVITEKNRAAEQIARILSNGKYKRIRIESIPVYEFSSGNQSWKIMGLAGHIMGYDYPSAYKDWRAVDPGTLLDIEPEKKVLKEEYASVIRKLANEASEIILACDYDREGENIGFEAKDIASKVSDVSFKRAKFSSLSPEEINRAFNSLVEPDVNMAMAAEARQILDLKMGVAFTRFITLSVREYVRTKKILSVGPCQSPTCGFVYERERTIRDFKPTDFWKIEALFNSGETNFPGSHRKGKIFNKDEAMSVYRKIKDCSSGSICERNVKESSVNPPNPLNTNELLKRGSNFLGISPENTLKIAEDLYLAGFISYPRTETNKYSKEFKFAEIIDEFRNGHYNDCVSLLPGDIHPKNGKKDSHDHPPIYPIKSASKKDVMKLSENPDYWNIYDLIVRHFFANLMPPAIFEKTHLAVLVKDEIFDSKGSVMKDAGWMQVYPFEKSSDKLLPRLQMGDGVNIEEISCNMSQTTPPKKLTEAELLTLMEHNGIGTKATASGHIETNKKRGYFENRGKTVSIMDRGFVLMDALNESVPSVIKPEVRARIESLIQDVESGNMDIDSAVLEGTDLIKKMYSCLSEGKDRLASKVVAAISDEAAQEDKKNFIGYCSQCNRILKIIKTDNGRFVGCTGYPQCKNTYPLPRKGALSILRSSECRRGGAAVIKVGKKYHWAVGIGPCFTCEFEKECFPPEIIGDCPECDGSMFVIQTEKSRFLGCTKRCGYTQSLPDKGRLTINEDKCENCGWNILRVKEMKKDALVICINRKCKKRYNKC
(806) DNA topoisomerase I [Methanocella paludicola SANAE]
3
MHLIITEKHDAANKIAGILFPDRSAERHGGVTVYRSKAAGAAVVGLAGHIVALDFPGEYSRWSAHPPSTLIGAPIVSVPTKKDIIGALASLAPSATKVTIATDYDREGELIGVEAYNIIHRLTKAPFERVHYSSFAKQEIEQAFARPVPLDFNLAAAGECRQEIDLVWGAALTRFVSLAGNKAGKDFLSVGRVQTPLLAIIVDREKEILAFVSKPYWELVATLLKGQEAFTAGHAKGRFDKKEEAAAIHKKLGKTALVKGVLRDRKKEPAPVPFSTTEFLKAAASIGYSAASAMQVAEELYINGWISYPRTDNTVYPATLDLRQTVGMFKASPEFAKSALELLGQKTLTATRGKVESKDHPPIYPVACASKTQMDERKWKLYELVVRRFFATLSPPCEWEMVKASIDISGEPFISDGKRMSAPGWRKHYPYGMPKDEVIPPLAVGDVLAVKKVDLLEKKTEPPRRYGQGKLIETMEKLGLGTKATRHEALSKLYNRGYIEGNPPKPTQTGITLIDALKAHAGAITSPGMTARLESDMDGIAESRLRKDDVTGESKAMLRTIFDQLESHRADIGRTLRAGSAMDSPIGPCPKCGSPLVIRETKADKRKFIACTGFPECRNTYNVPPGTLKFDKKACEKHKLHIVKVTPPSIIDSQGKKVKGKPYEYGCPACKKEAFYKPP
(952) DNA topoisomerase 1 [Methanocella paludicola SANAE]
3
MHLIVTEKNITARKIAQLLLGSAKERKVDGVSVYEGDDTAVVGLSGHIVNIDFPDEYNNWQSTAPKDLIWANTEMRYTQKKIATALKKLAKEATHVTIATDFDREGELIGVEAYHIIKDAAPAAKFDRARYSAITRQEIEHAFANTVPIDFDLAAAGEARQKIDLVWGAALTRYISLTCGRLGNSFLSVGRVQTPLLALIVDREKDIKAFTPTPYWEIYATFTNGEEFVAGHTGNRFTEKAKAEGIMARLGRTGKVADYKKEPRVEYPPIPFSTTEFIRAAASIGFSAANAMRIAENLYVNGWISYPRTDNTVYPASLNLKEIVAQFAGGEFGKYAQRLLEQSSFKPTRGKKETTDHPPIYPVASARKSEIKADEWRVYELVVSRFFATLAPPAEYEVRNVCVDVNGERFKATGSMLSTPGYRLYYPYGMAKEELLPELSVGQELAVKNAAMDEKLTKPPVRYGQGKLVKMMEDLGLGTKSTRHEAIQKLYARNYVHGNPPVPTNTAFAVVGALEKYADLITKPDMTSRLESDMDSIAEGKIKEEAVVQESQGMLETIFDDLDKNHNDIREVLYEGLREDRRIGKCPSCGKDLYVRKSKKGGRFIGCEGYPECNFILPLPRMGTIIVTEKNCDKHGISHIRIVNGGSKPWDLGCPQCNYEEWQKKNAAEKVTPVRKSSEPAKKPARKTTKKKAADDKGAPLVKS
(1679) DNA topoisomerase 1 [Methanobrevibacter smithii ATCC 35061]
3
MNEVIICEKPKSAEKIAKALSSKAKKNVFNKKVKYWTLERDGKDITVLSAVGHLYSLTPDNPKDKVYFDLHWAPLFEIDKKYKNYTKDYVRAIKKYAKDADSYIHACDYDIEGTLIGYHALKYGCGDDALKKSSRMKFSTLTKKDIVEAYENRIPIDRHQVDSGVARHILDFYFGVNISKALMKSVSAAKKRFLKLSAGRVQTPTLSILVDREKEIKKFVPKPYWLIKALLDGEIEADHVDGKIFDKTRAEEIFSNCENSDAAVDKIKYSNSTTKPPVPFNLGGLQSEAYNVFGFSPKKTQTIAQSLYTAGYTSYPRTSSQKLPESLDFKSIFLQLSKNSEFRTHISALPAKLKPNEGKKEDAAHPAIHPTGILPDKLDKDELKIYELIVYRFISVFFEAATFETMSTTLDIGGEKFKFRRRRVTHKGWLEHYPFKKIDNEEFPDVKEGDSIIVKEIVSEEKETKPPARYNQASLIKELEKRELGTKATRADIIDKLYDRKYITGNKIEVNQLGENIIDTLSEYCSNLTSEELTRDFENKLEGIDNDKATRESVVAEGEKEVKVILGDIDKNKVKIGSQIYDAYQESNIVGKCKCGGNLVKKYSPKNKSTFVGCSNYPDCKATYSVPKGANFLKKTCKTCGLPIISFGKPRQHACLDPNCGKENTKPREMKVVGVCPSCGKELIKRSGRYGEFVGCRGFPKCRFTCSLDELKDKVQ
(1885) DNA topoisomerase 1 [Thermoplasma acidophilum DSM 1728]
3
MDGFRIIIAEKADAGRRIAYFLSGGQVKSHRAKGTSYLEFEYNGSKTYLIPLSGHIVEADFESGYSDWNKIDLSDLIDARIVKNIKNKVAYQTLQAFRGKVEEIVIATDYDREGELIGVEALDIIKEGKEEIRRAKFSALTKNEILDSFKNLIGVNYSLADAADARESIDLIWGSVLTRFFSVTTGRLGKSFLSAGRVQTPTLAIVVDREREIQSFRPERYWTISITFDKDGQFKARYPENIKDQDTAEKIYEAIKGKNGRVSSYTSKEDHIRRPAPFSTTEFLREASRIGIMPTKAMSIAENLYMRGLISYPRTDNTVYPRSINLKSVLKKLENTAYSKYVKEIETFDRILPSRGRIETTDHPPIYPVDSPKEQLKGDYGRVYDLILRHFLSTLYRDGKKTVAEAEIYVNGYTFKAAGQHTTDRGWTEIYGYDPKDVYLPELTEGEDLKAIDWNIQREETKPPPRYDMSSLLKKMEELNLGTKSTRHDIIGKLIERGFIEGNPVKPTPLGMAFIDAVRSVNSHIADPEMTAKLEEDMDRIEKNEMSKNDVVEESKKMLHEVLSHFLTKTADVKDIITKGINAGQEIGDCPFHEGKKIMVIRDRFTYTVRCEDPSCKINFRIKRNGSITLSDQKCPVCGLPMIKIIRKGQSPEIKCIDPDCSYNRENEDYGECPADHGRLVLRQSKYGKRFLGCSNYPKCTVTYPLPQMGRITKTGEVCPYCGAPILALSRNGRKWKFCPNMQCEYNKKRKPEAAVEKSVRKKGRNASKS
(1397) DNA topoisomerase [Picrophilus torridus DSM 9790]
3
MTLNLIIAEKMDAGRRIAYILSKKTSKQKRSKGSFYIEFESNNERNVLVPLSGHVLEADFPSDFKDWLKSDLNLLIDSRIVYNVKNQRAINTLKNFKDADNIIIATDYDREGELIGTEVLKFLNAKNIKRAKFSALTEKEINDAFSNTINVDYNLADSAQAREEIDLIWGAVLTRFFSIASNRLWKDFISVGRVQTPTLGLIYKREMEIRSFVPEKYYKIKITFNKNRDFDAYYNNELKDRKTAEKIFSEVKNMPGRVKSFDKEEYYIYRPAPFNTNEFLREASYLGISPARAMNIAEKLYMQGLISYPRTDNTVYNKSINLKSIVEKLKKSEFSMEADLVLSQEKILPSRGKTEATDHPPIYPVSVPSKELTGDYKKIYELIVRRFLATLYKNAVAVRSTALIDVNGHDFISEGNIIKENGWYDIYKYKSYREYFVPDLEKNEVLNGRDYELQEKETEPPRRYDVSSLLKAMESLNLGTKSTRHDIIDKLYSRNFVTGNPVKITPLGEGFIKSIIDTNPRISEPEMTAELEMDMDKIASGTKTKDDVVNESRRMLHSVLNDFQGRTSEINKTINDYLNTGESLGRCPLDGNELFLIKYRDHYKIKCGDENCRIDFNIYSNGRIQLNDSKCPVCSLPMIKIIRKGQSPEVKCIDPACDYNKEKDIYGTCPADGGNLVLRQSRYGKRFLGCSNYPKCTVTYPLPQKGILKKTDKKCQYCGAPIIVLINGRRHFEFCPKIDCEFNRGGKIEKNKV
(1203) DNA topoisomerase 1 [Pyrococcus furiosus DSM 3638]
3
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTANYEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELWYLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLELAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
(1220) Reverse gyrase [Pyrococcus furiosus DSM 3638]
6
MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS
(1204) DNA topoisomerase 1 [Pyrococcus furiosus DSM 3638]
3
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTANYEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELWYLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLELAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
(1219) Reverse gyrase [Pyrococcus furiosus DSM 3638]
6
MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS
(1724) DNA topoisomerase 1 [Haloferax volcanii DS2]
3
MSRGPELIITEKDNAARRIADILSGETASAERMNGVNVYKWGGKRCIGLSGHVVGVDFPPEYNDWRDVEPVELIGAPVEKHPTQENIVAALRRLARRAGKVTIATDYDREGELIGKEAYELVRDVNEDVPVDRVRFSSITNREVTEAFENPDDLDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGNDFISVGRVQGPTLKLIVDREREIDAFDPEDYWELFSKLTKDADGDAESFEAQYFYLDDDGTEAERIWDEDDAEEAYQTLLGVEAAEVSSVNRRTRTDTPPAPFNTTQFIRAAGSIGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPRELLGAFEGDRRFKEDAESLLEQEEIEPTEGDNETTDHPPIHPTGELPSASDLSDDEWDVYELVVRRFFATVAEDAVWEHLRVVAEVEGLSLKANGKRLLEAGYHDVYPYFNSSESFVPDVEEGESLVLSDTHLDAKQTQPPRRYGQSRLIETMEQMGIGTKATRHDVIQKLYDRGYIESDPPRPTRLARAVVEASEDFAKLIVSEEMTSQLESDMLAIARGEATLEDVTEESKEMLGEVFEGLMESREELGKQLQDSLKADKTVGTCPDCGGDLVVRKSRRGSYFIGCDSYPDCTYTLPLPSTGKPLIMEESCEDHDLHHIKMLAGRKTFVHGCPLCKAEEADEEDDLVIGTCPECGEEHDGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGDIEVTDESCEEHDLPELRITYEGDREPWELGCPICNYREYQAQQNGEGGSELESINGIGAKTAEKLKDAGIEDVKTLKASEPDDIAAKVEGVGADTVRKWQTAAD
(1725) DNA topoisomerase 1 [Haloferax volcanii DS2]
3
MSRGPELIITEKDNAARRIADILSGETASAERMNGVNVYKWGGKRCIGLSGHVVGVDFPPEYNDWRDVEPVELIGAPVEKHPTQENIVAALRRLARRAGKVTIATDYDREGELIGKEAYELVRDVNEDVPVDRVRFSSITNREVTEAFENPDDLDFDLAAAGEARQIIDLVWGAALTRFLSLSARQLGNDFISVGRVQGPTLKLIVDREREIDAFDPEDYWELFSKLTKDADGDAESFEAQYFYLDDDGTEAERIWDEDDAEEAYQTLLGVEAAEVSSVNRRTRTDTPPAPFNTTQFIRAAGSIGYSAQRAMSIAEDLYTAGYITYPRTDNTVYPDDLDPRELLGAFEGDRRFKEDAESLLEQEEIEPTEGDNETTDHPPIHPTGELPSASDLSDDEWDVYELVVRRFFATVAEDAVWEHLRVVAEVEGLSLKANGKRLLEAGYHDVYPYFNSSESFVPDVEEGESLVLSDTHLDAKQTQPPRRYGQSRLIETMEQMGIGTKATRHDVIQKLYDRGYIESDPPRPTRLARAVVEASEDFAKLIVSEEMTSQLESDMLAIARGEATLEDVTEESKEMLGEVFEGLMESREELGKQLQDSLKADKTVGTCPDCGGDLVVRKSRRGSYFIGCDSYPDCTYTLPLPSTGKPLIMEESCEDHDLHHIKMLAGRKTFVHGCPLCKAEEADEEDDLVIGTCPECGEEHDGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGDIEVTDESCEEHDLPELRITYEGDREPWELGCPICNYREYQAQQNGEGGSELESINGIGAKTAEKLKDAGIEDVKTLKASEPDDIAAKVEGVGADTVRKWQTAAD
(1607) Reverse gyrase [Methanocaldococcus fervens AG86]
6
MLVLLMIPMIYKEMCPNCNGEITSKRLEIGVCEKCLKEEKAFEKLKLCEKLREEKTLKNLKNYCNIWNEFKEFEEFVKDLGFELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGILMSLFLSKKGKKCYIILPTTLLVKQTYEKMISLIEKNNLNVKVVAYHSELSTKEKKEAKERIDNNDYDILITTSNFLAKNMPNNVFDFIFVDDVDALLKASKNIDRTLKLLGFDDEIINEAYKIIYLIKIGKIESALKKREFLKKKISKINHGCLIIASATGKSYGDRVKLYRELLDFEIGFGMNKLRDVADIYDEEFSKEKILEYVKLFGSGGIVFVSIDYGVEKAQEIEKFLLKNNIKAKLIHSKDKKGFDDFRNGEIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRLKEYINSLKEKGELKEDIDIEGKTEEEIREIIVEKLKIKNFSLRKEDGEYLLLIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDEKEIFEALKKYMLFMYESEFRKIDEINLEELIKKIDEDREKIKLGRAKGKVPDLLKSVLMVVESPNKARTIANFFGKPSVRKINNRNIYEVCIGDLNLIITASGGHVFDLVTKEGFYGIKIDNNLYIPIYASIKKVNGEQFTDQKNFEKLIKQLMERGERVNAMDAKENIEIIREIADEVDAIFIATDIDTEGEKIGYDIALNALPFNKNIYRVGFNEITKRAILKAVESFKKGEELSLDENKVKGQIVRRIEDRWIGFRLSQKLWEVFNKNYLSAGRVQTPVLGWIIERYNEHKIKVPYLSLRLENDIYVGKIWEEEFNKDEVEVEVNIYDKEISPLPPFTTDTLLEEATKRFGLSADEVMAIAQELFELGLTTYHRTSSTRVSLDGMRVAKEYLKLNNLEDYLKNREYFMEGAHECIRPTKPMDTEELIEFLKESNIKLTKNHIKVYDLIFRRFLASQMKEAVVEYEEIYIKDLDEKIEGYIDVKFDGWSKIYNLKLKKLPKVEKNSLKILEKKITKIPKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVTKSKNKGKLIPTKLGTEVYNYLINNYPNLISEERTRELEEIMDKIENGEVDYLEVLKALHEEILSIK
(1208) DNA topoisomerase 1 [Methanocaldococcus fervens AG86]
3
MTALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKENKEFGTYPVFDVKWVPASVDKGKEYVNKYIKALKKLSKEANEFYVATDWDIEGELIGYHALKYCCGREKAKRMRFSSLTKKEIVKAFENPDEIDYGLVDAGESRHIVDWYFGINLSRALMNAIRAVNRWKTMSIGRVQGPALAFLTERELEIKKFVPKPYWVIEALLKDNLKAIHEKEKFWDEKEAKNIYEKIKDEKTAKVLEVKKTKRKIKPLPPFDLGTLQREAYSYFKISPKETQEIAQNLYEKALISYPRTSSQKLPKDRKYLEDILKIIKEHPIYGKWVGRILKDNLKPVGGKKEDPAHPAIHIVDVPKEELSEKEKKIYDLIARRTLAAFWDNAEREYLNIKIDIKGEIFKLSGSRTVKEGWHEIYYFPKFDEVELPPLKKNDIINIEKITITRKETQPPKRYTVASIIKELEKKGLGTKATRAEIVDKLIKRGYVVDEGSLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVLEEAEKKLRKILEEFKKKEKDIGTYLIKNLDSTNKKAKIVGKCPKCGGDLILIRYNKSRFVGCSNYPECDVKYSLPDKGRIKIPNKSCEACKSPILKIGDKEVCINPECPLKYVEVKEENKKCPKCGGDLILKKGIYGAFYGCSNYPKCKYTEPVNKKEKEVVGKCPKCGGDLVIREGKFGKFAGCSNYPKCKYTEKLKIVEKEEK
(746) Reverse gyrase [Staphylothermus marinus F1]
6
MEKILDPIYKNLCPTCRGDVFANSLWDFGVCGKCSDEPGNSINAVTLYHAFKEDLEDFTHFFGKATGDLNPWGAQLTWAKRLLNGENTVIVAPTGMGKTTLLIVYSVYVAKNYNKKVLFLAPTRALAKQIYTRIIEAVKNVCGTCINVLFYDSGLSKKRREEVLLKIKNNEYDILVLTNHFLIRHYDLLDPNHIGLIVIDDVDSLMRSSKNILRLMKLLGFREELIEKAKKRNSIIWKLMLSKSLNKEEDYRKYIEELIEIEAEIDELLRNSSRKQVVIASATGRMKGIYAKVMRDLLRIDVSGITIYGRNITDTYLLISDHVRDTDKILGFIETLGPGALIFISPRHPLKKNLIELVGLLRRKLEEKGYRVAEANPSTIKKFVRGEYDFLIGSSSYYGVSVRGIDAPETIKYVLFIGTPLFTVELGSFLASPNMLIRVSLMLSEVLGDQRFRGVASTIRKLVFPLNNGEIKLLSMLLKNKITINDLGKDSRIVKVYEQILDFYNDIRKSLEELLSKKKVVDMNTITFYHDNNKFYALIPDVMTYIQASGRCSRLYLGKMTHGLSLVVEYDFLSNLVNGLSLKMNMFSRGFGFKDINDIDLYEEKKLLEKTRKELKGLVLTYRNILVIVESPTKAKTIARFFGKPVRRKIGSISVYEIPFVKDSEVIHLNIVATRGHLFDLTTDPSIPNHGVLIENNRISPVYTSIKRCRVCGYQFTYGDRCPRCGSTSFTDSYEVVNVLRKLAQEADEVYIATDPDIEGEKIAYDVYLTIKGFVDRVWRIELHEITLNEFLNALENKRNINLKLVEAEIYRRVLDRVIGFSLSQELWRKYSKNWLGAGRVQTPVLGWIIDHYNKYVSNKCRKIIYITEREGLKFSICIDLKDRDLYEKMRSVEYVTLVLKNSRIETFNPPPPYTTDELLYDASRIGIPSTLTMKIAQELFESGLITYHRTSYHYVSSAGISVASKYLENKNLSKHFHPSHWGNKGAHEAIRPVHPLDREDLEKAVVEGIITPTIPLTWLHYRIYDLIFKRFISSQMNPYKALISEYDVVINNEIVKTLVLPIEVVEEGFNIVMRPKTYGFLKGHDRIDISIKDIKTMITSTKPLCSEGGLVKLMREHGLGRPSTYSKIISNIVRHGYVIRSKKRGFLIPTKTGIEVYDYLSNSFPELVSIDTTRDMEMRIDLIAKGEMRAADEISRVIDRIRRYKLPLSIREVVAEASA
(926) Reverse gyrase [Staphylothermus marinus F1]
6
MVELKHIHGYYRYSCPNCGGEDSDLRLIHKAPCDKCIEEELFYRIRENIGEKSYKEILETYYRMLLKNNKLKKRFEFLYKFEEKLEKFEKFFSEATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYLSKKQIMIQKNRISRKKIYLVFPTTPLLLQAEKKLRKLAEQEKIPVCQEEDSDQTCLNIISIHGRVPKKKREKLLEEIRSGNFDILLSTNMFMHKNYELLLDKKYELIVMDDVDAILRSGKAIRILFYILGLTDQEINEAIEYLKLRQRLALKLSEEERRELEEKLETLEKRIEKYKRKIDTVVIVSSATGKPRGIYPRLFRILLNFEAGSRAEAIRNIVDTYTYSKESLEQTIIRLAKKLGDGGLIFVPIDKGVEYAETIAELLKKHGINAEAFHAKKAVKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFSTRLESPSPIDVLRIFTILRDVLEGEEKRKAEILIGRISLRLRRLSQGALMKLKEDFMKKLQGEEVEEYPLLSLLMEALSMARELLSKPEIWEKLKQKGDVALVQEDGKSYILIPDVATYIQASGRTSRLYPGGITKGLSIVIVDDQRLLNGLIKRMRWLFEEFDMKRLDEVDLDKLMKEINEERRKVKMILEGRIEVEKTLELTKSALLIVESPNKARTIANFFGKPSIRILENGMPVYDVTTGDYVLSIIASIGHVYDLVVDDGLYNYGVRLVGDKFIPVYTDIKRCNKCGYQFTAETNTCPKCGSRDISRKLDIVETLRELANEVDVVFIGTDPDTEGEKIGWDIKVLLEPYAREIKRVEFHEITRKAILNAIRNPRDFDMKLVEAQIVRRVEDRWLGFALSKKVQKYFWPIYCFKVLHPLLNKYVREGKRITDKMPFCCIENRNLSAGRVQTPVLGYIIRRFKEHNDESKFRYLLTIKINDSRLRVDIDRSVLEIIGITSHRNLIGYRVEVREEDRKEEIINPPPPFTTDTLLEEASIRLGLSTTRTMEIAQELFELGLITYHRTDSTRISDAGINVARQYLEEKLGEKAKEVFKPRTWGVGGAHEAIRPTRPIDADRLAELIREGALILARPLTRLHYMVYKLIFNRFIASQMIPAKIVKQVLKIRMNGYEKKVERVIGIIEKGFLEFYQTVNVEEEVKPGTYPVVDVEVLKPPLARYHDVIKWMKTNGIGRPSTYAKIIQTLIDRKYVNVSKRVKALIPTKRGTMVYEEFLDKYYKDVVSVEVTRELEKKMKEVEEGIRDYQEVLHEIFNELKTKIIDNPVVNKELEQKWSKHCGQIESSK
(636) DNA topoisomerase 1 [Staphylothermus marinus F1]
3
MGDKAKKSIIDYILSYSEKQKKKPVKTKEKTSSKKAIEKTEIQITHNIWDLIGKIVVIAEKPKAANKIALALSRNPIRKSMYGIPYYLIKNRHSSIIVASAAGHLYGLHTDQYGYPVFKYEWKPLYQIDPKAKHTEKFIMVLSKLCSNADYYVNACDYDIEGSVIGYLIIYFHGDLEKSLRAKFSSLTIEELRESFRKLTSLDWEMIEAGLCRHELDWIWGINISRALMSSVKIASGKRVILSAGRVQTPTLRYVVEKDIERRLFIPLPQYSLSINIFKNNYEIHVEYKGKSVETKKNAKEIIDEIKRTGYLIVKKYEEKIYTLNPPPAFNLGDLQEEAARIYGFSPYKTQSIAEKLYLDALISYPRTNSQKLPPTLNYKAIMNKLSRINNYKELVSNLLVETKGVLKPVQGSKDDPAHPAIYPTGVKPKDLGKDEWKIYDLIVRRFLAAFASKARISHRIVYLEYPKDPSMVFQASGQKILDLGWLRYYPFSKPEERFLPKFQYGEKVKIVKASIRKTYTKPPEKINKIKILRWMENVGIGTEATRARIIEILFSRYYLRSVGGRVEATDLGLGIIEVLMEYFPEITSVSLTRHFEEEMEKIRLGVKRREEVVKDAKNTLIKLIVSFDKKKYQIGKTLSYRLGYITPINKCILCNREAYKNNLCKYHYRALNTVIKTYDEWKRREGVDWNKYLSSIKKLKSTGKWIVEVIQNFEKIKYSPSE
(1120) Reverse gyrase [Candidatus Caldiarchaeum subterraneum]
6
MKSIYASLCPNCGGAITDEELIGNGVCSRCVSQDGRLKPGKYTKALELEERYREFADFFSRVVGSPPWSLQRTWIRRTFLGRSFSIVSPTGTGKTTFFIAMAIYQASKGKKSYIIVPTSLLAQQIHERALSMAAKHGEKAPKIAGYFSGMKKSEAEEMLQKIRDEEFNILVTTDRFLNTRFELLRGKKFSFIFVDDVDSFLKSARNIDKVLLLMGFDEEEIERQLSLVSRRSEKNEAGEHASREIAKPDSILLVAGATAKGRRTKRIQLFRRLLNFEPGGSIEFVRNISNMYLRPSKNMWEQVAELVKTHGGGCLIFVPQTAGVESAKELAKFLNSQGISAYAYERMDAKMLGRFELGEYDVLVGVASRRSPLARGIDLPERIRYVIFAGVPRRELNVSWREHRPSMLLSLLRNLYSILREKNESELVQVTGMLKKCVPTDREVLEIVREGLESSRQPEGFAGYVYSAVTRAHQLLKTYIGEEELRRVAENLDMRLRVDENGVSIILPDIDGYIQASGRSSRMYAGGITRGISILIVDDEKAFRGISRALETIYEETFQEYTLEQAREEFKQCDRDRQFLREIRTGSARLESLDILSSSLIVVESPTKARTLAYFFGKPARRVVDGLTVYESVGEGYVACLTACQGHLVDITTSQGFHGVWVHDGEFVPMYVDIRRCSKCGEQFTDSEVCPNCRSDKYFTKLSIIESLRKLALEFDRVFIATDPDTEGEKIGYDLYVSIWPFNKRIERLELHEITRKALRDAFKSPRSISLPLVEAQVVRRIEDRWVGFELSRRLWEFFGEKHLSAGRVQTPVLGWIIQRMEEAKKKRLVASMTFEDGSELMLDSIEDVDVVKRLYAEGVLNVEVADVKYVETVVPAVKPYTTDSLLRDASIFLRLSAAEAMDAAQTLFESGLITYHRTGSTYVSSTGLSVARNYLEENFPGLFVARHHGEPGAHECIRPTKPLSRKQLELYLQSGLIRVPMRIGDREFMLYDLVFRRFMASQMKDALVQRQICKLMILGKTYDIERIVDVIEPGFLHLYQVIKTVKALEPGVHRVLNLQIKSMQAVPFFREGDIIALMRERGIGRPSTYAQVLNLLYKRRYIFNDNGRVLATKLGKTIYGYLVSNFGSFVSEALTRRLEELMESIESGKVSYQEVLKELYRETLQISKTPARAA
(1281) DNA topoisomerase III [Candidatus Caldiarchaeum subterraneum]
3
MTSTSDKDTMDGEKLIIVAEKASVARAIKAVVSAAKANAVVSSVRGHMMEADLPDGYEWGAKHPFEIIKLRKVVDKISDNRVFEQLVKVFSGGGVLVIATDNDSEGELIGYEILQVYRRVTGGEPVVYRMRFNSVDRRELFASLRNLEKGLNMRWVEKARFRQIFDLVTGAAFTRLLTLSTRRLAPVRVISWGSCQTPTLNFVVEREKEIQQFKPQKYWVIEATLRKASGEEFKAATQQIWNRDEAEQVFEKARKAGEAVVTSYTKSEKTLPRPLPMRTDDVLRDLTRITGVSANRLLSMMEELYAEGYISYPRTDTNRYRRGFDFQTPLKAVTAADALRDAKPDKAEPDPRNGSRDDGAHPPIYPVATFRGSGVLMQIWEYIACRFYANAFFDDAVQSTAKAEIGIDGIAFSAEGSSVTKQGYLQVFSYFRPRDKPLPELMVGEKLQIIDVTIREDETKPPPRLTEADLLRLMEKNGIGTDATRASFPQLITERNYAVRAGRFFKPTPLGMALIESLAEADTRLITPETRRLVEDYMAKIERGETSFQESLEQSLSLYEELLRRCSDKIDEISRRLAQHVKPFARKRQRKKKGEPSLMNSNKLNK
(1280) DNA topoisomerase III [Candidatus Caldiarchaeum subterraneum]
3
MTSTSDKDTMDGEKLIIVAEKASVARAIKAVVSAAKANAVVSSVRGHMMEADLPDGYEWGAKHPFEIIKLRKVVDKISDNRVFEQLVKVFSGGGVLVIATDNDSEGELIGYEILQVYRRVTGGEPVVYRMRFNSVDRRELFASLRNLEKGLNMRWVEKARFRQIFDLVTGAAFTRLLTLSTRRLAPVRVISWGSCQTPTLNFVVEREKEIQQFKPQKYWVIEATLRKASGEEFKAATQQIWNRDEAEQVFEKARKAGEAVVTSYTKSEKTLPRPLPMRTDDVLRDLTRITGVSANRLLSMMEELYAEGYISYPRTDTNRYRRGFDFQTPLKAVTAADALRDAKPDKAEPDPRNGSRDDGAHPPIYPVATFRGSGVLMQIWEYIACRFYANAFFDDAVQSTAKAEIGIDGIAFSAEGSSVTKQGYLQVFSYFRPRDKPLPELMVGEKLQIIDVTIREDETKPPPRLTEADLLRLMEKNGIGTDATRASFPQLITERNYAVRAGRFFKPTPLGMALIESLAEADTRLITPETRRLVEDYMAKIERGETSFQESLEQSLSLYEELLRRCSDKIDEISRRLAQHVKPFARKRQRKKKGEPSLMNSNKLNK
(32) DNA topoisomerase 1 [Methanothermus fervidus DSM 2088]
3
MTLVNEVIICEKPQAAEKIANSLSSSTKKKKYKNVPYWEIKKTDKKILVVPAVGHLYTLAPSNKKKDYFFDLEWTPVYLVDKKRKYIKNYIDAIKKLGKKADRYIHACDYDIEGTLIGYNVLRYCIGKKSLKKSLRMKFSTLTKRDIRKAYENLTSIDYGQVNGGITRHFLDFLFGVNISRALMNSIQNSTKKFVKLSAGRVQTPTLSILVDREREIKKFKPKTYWVIEAKTKFFTAKFKEQKIFDKNKALKIVKECKNKNAIVKSVKITKRYRNPPVPFDLTTLQSEAYRLFGFSPRKTQSLAQNLYLGGYISYPRTSSQKLPPSIDYEKIFEGLSKNPKFERYISKLSKPFKPYEGKKTDEAHPAIHPTGVMPKNLNEDESKLYELIVHRFIAVFADKAKIANLRGVLSINDYEFIFNKQKIIKEGWMSFYPYTSVKNEEFPEIKEGDKLKIEKIIKEEKKTKPPARYTAASLIKEMEVRGLGTKSTRAEIISALYDRKYIEGRKIKVKPLGIKIINILKKYCKKITSEKLTREFEKKIKRIIKGEINKENVITEAKNEVKDILNSIEDKQKEIGEELYNAYKKSKIIGKCKCGGNLIIRYSQKYKKRFVGCSNYPACKVTYSLPKNAIILESKCKRCGLPLISYGNPRRVACLNPKCGKKIDEEKIVGKCPKCGNDLIIKSGRYGKFVGCKGFPKCKYVRSI
(1117) Reverse gyrase [Methanothermus fervidus DSM 2088]
6
MYRAIYKGMCPNCGKEIDDSRLNAKNPCKSCVEKKLQCEDYHELLEKIEEYLKENNNLYGWKEIYELHRDLKDIENLFEKATNSKFWNIQKTWFIRLIKGESFPIIAPTGVGKSIFGIFASLYYALKNKKSYIIVPTTSLVLQTVEKIKKFMEKTQIKVNLAFYHGKLKEKEKMKNKIENDDFDILVTTSQYLAINFDILKNKKFDFIFIDDVDAFLKSSRNIDRSLILLGFSEEIIEKGWELIKLKERGPKRNSEQIKKIENKIKEFKEKNKIGNLVVASATIKVKNKRIKIYRELLNFEITGEVPTIRNMVDSYIKTDEKIEKHLVKLLNILGNGGIIFVPTDQGIEKAKKIENYLKNNGFKVKLVSSADKTGIKEFKEGKIDYLVGVATYYGVLVRGLDIPERVRYTIFTGVPKHRFVINLDSPRLYSIIILLRVLIDVLKGNYKRKAESLYTKLQKIPKYKIKEIEKKLENGHADSRITKIYDDSVKFVRKIFKKEEIRKKIFSNEFLSMEIQNNKLCIKFPDLRTYIQASGRASRLFAGGITHGLSVVIIDDEKVFEGLKRQYKWQFQKHEFKAFEKLKLKKILNKIDEDRKKVKAIKKHGKFEIKNIVKSALFIVESPNKARTIANMFGNIGKRRIGRLTVYETNIGNRILMIVATGGHIFDLVNDEGFHGIKIENGHFIPIYDTIKRCRECGNQFVNNNGSTCPKCKSNDIIDTFENILVMRELAQEVDEVLIGTDPDVEGEKIAWDVMNVLSPYTSNLKRVEFHEVTRSAILKAIKEASKINIKRVEAQIVRRIEDRWIGFELSQKLWEEFDNTYLSAGRVQTPVLGWIIKRYNDFRKSETYFTKLTLENRMEIILEGKKETDYLEVKKVNKEEKDINPNPPYTTDTLLTDASRILGFPTTKTMRLAQDLFEMGFVTYIRTDATYVSDVGNIIARDYIKNEIGEKYFKARKWGKEGAHECIRPTRPIDSEKIIQLIRNNVIRTTKKLTSDHLRLYNLIFKRFMASQMTPVNLHYQKIVLGIDDEEIEIEGYTDIIDPGWTKIVRLPMKKLPEVKEGQKIKIKEIKTWKAPKISLFTEGDVIEKMKKSGIGRPSTYSKIVNTLLDRRYVIKTKLKKKLLPTKLGVNVYNYLIHTYEKLVSEERTRELEKVMDEIEEGSRNYQEVLNSIYEEIKQFV
(1263) DNA topoisomerase 1 [Methanosphaera stadtmanae DSM 3091]
3
MSELIICEKPKVAEKVAKALSDSPVKNSYKRVPYYEFTNGNGTKITVLSAVGHLFSLKAKNKKDKRLFDVEWVPLSETDKSKKYVKNYIDTIKKFSKDADRFIHACDYDTEGTLIGFNALRYICGEDSIDKSFRMKFSALTKKDLIESYSNAYPLKEDKSWVDSGETRHVLDFLFGVNISKSMTDSVLNVTNRYVQLSAGRVQTPTLAILTEREKEIQKFIPEPYWLIKAKLQKSIVADHKKGKIFDKKEVDAILKNCKGKDATVEKITNRKTKKDLPVPFELGTLQSEAYAQFGFTPRKTQQIAQNLYVEGYTSYPRTSSQKLPESLGLPNILSQLSKHPKYKDKISQLEQPYKPHEGKKTDEAHPAIHPTGTLPKDISEDYQKIYDLITYRFISIFGKPAEMESIKVELDIGGEPFSFSRQRISKEGWLSLDPYQYKKVKNEEFPEIKEGQTTKAKVASEEKETKPPARYNQASIIRELEKRGLGTKSTRANIVSILYTRKYVEGKKIEVSQLGQQIINTLEKYSERITSEQMTREFETDISNIKENEITEATVIEDAKKELNGILDSIDDNIEDIGKELYGAYEQSRVVGKCGCGGNLIIISSPRGGKFVGCSNYPDCKKTYSLPAGANVLKTTCEKCGLPLISYGKPRQRACLDFECANGGQKSTNDVVGECPDCGKDLIKRMGRFGEFIGCTGFPKCRFTSSIDDFEKSKKESEKKD
(1048) DNA topoisomerase 1 [Methanocaldococcus sp. FS406-22]
3
MTALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERNGKKIIVASAVGHLFTLVEKENKEFGSYPVFDIKWVPASVEKGKEYVNKYIKALKKLSKEADEFYIATDWDIEGELIGYHALKYCCGKEKAKRMRFSSLTKKEIVKAFENPDEIDYGLVDAGESRHIVDWYFGINLSRALMNAIRAVNRWKTMSIGRVQGPALAFLTERELEIKKFVPKPYWVIEALFKDNLKAIHEKEKFWDEKEAKSVYEKIKNEKFGKVVEIKKTKRKIKPLPPFDLGTLQREAYSYFKISPKETQEIAQSLYEKGLCLHPDTLILLPDGIKKIKDLDDEGEVLCLNKDLKLTKSKYKLLKRTIKEKLIKITLNDGTELITTKEHPILVYRDELIFIPAEKLKENEQVVMFINNSEKTFKIKKTKFIDFILENKKYSHHYSIICTSDWKNKFKSGIAKKFDLSNQLSKNKGLSLDRLRKLSNYIIDRDLKRIANGDVYIQKIKKIEEIEYEGEVYDLTVKDYHNFIANGIVVHNCSYPRTSSQKLPKDRKYLEDILNIIKNHPVYGKWAERILKENLKPVEGKKEDPAHPAIHIVDIPKEELSEKEKKIYDLIARRTLAAFWDNAEREYLNVKVDIKGEKFKLSGSRTVKEGWHEIYYFPKFDEIELPALKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKKGLGTKATRAEIVDKLIKRGYVIDDGSLKVTDLGISVIETLKKFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVLEEAEKRLRKILEEFKKKEEDIGIYLIKNLDATNKKAKIVGKCPKCGGDLILIRHKKGRFVGCSNYPECDVKYSLPDKGRIKIPNKVCEACKSPILKIGDREVCINPECPLKQVEVKEDDRICPKCGAKLVLKKGIYGAFYGCSNYPKCKYTEPINKKEVVGKCPKCGGDLVVRDGKFGKFVGCSNYPKCKYTEKLKSNEKEK
(561) Reverse gyrase [Methanocaldococcus sp. FS406-22]
6
MIPMIYKEMCPNCNGEITSERLAIGVCEKCLKEKNVFEKLKLCEKLREEKTLKELKSYCIIWNEFKEFEEFAKSLGYELLSIQKMWAKRVLKNKSFSIVAPTGVGKSFFGILMSLFLAKKGKRCYIILPTTLLVKQTYEKMLSLVEKNNLNIKVVAYHSELSTKEKKEAKERIENNDYDVLITTSNFLTKNMPNCRFDFVFVDDVDALLKASKNIDRTLKLLGFDEEIINEAYKIIYLIKIGKIEDAMKKREILKEKVAKIKHGCLIIASATGKSYGDRVKLYRELLDFEIGFGMNKLRDVVDIYDEEFSKEKILEYIKLFGSGGIVFVSIDYGVEKAQEIEKYLLDNNIKAKLIHSKDKKGFDDFREGKIDVLIGVASYYGVLVRGLDMPERVRYAIFYGIPKFKIRLKEYINSLKEKGELKEDIDIEGKTEEEIRQIITEKLKIKNFSLRKEDDEYLLLIPDVKTYIQASGRTSRMTEFGLTKGASIVLVDEKEIFEALKKYMLFMYESEFKRIDEINLEELIKKIDEDREKIKVGRAKGKVPDLLKSVLMVVESPNKARTIANFFGKPSVRKINNRNVYEVCIGDLNLIITASGGHVFDLVTKEGFYGVKIEDNLYIPIYTSIKKVNGEQFTDQKDLEELIRQLMEKGEKVNAMDAKENVEIIREIADEVDAIFIATDIDTEGEKIGYDIAINALPFNKNIYRVGFNEITKRAILKAVESFKKGDKLELDENKVRGQIVRRIEDRWIGFRLSQKLWEVFDKNYLSAGRVQTPVLGWIIERYNEHKIKVPYLSLKLENDIYIGKIWEDEFDKDEVEVEVKVYEKEIPPLPPFTTDTLLEEATKRFGLSTDEVMSIAQELFELGLTSYHRTSSTRVSLDGMRVAREYLKLNNMEDYLKNREYFMEGAHECIRPTKPMDTEELIEFLKENNIKLTKNHIKVYDLIFRRFIASQMKEAVVEYEEIYIKDLDEKVEGYIDIKFDGWSRIYNLKLKKLPRIEKSTLKVLDKKLRKIPKVPLYDEGEVVKLMKERGIGRPSTYAQIIKKLLDRGYVIKSRDKNKLIPTKLGIDVYNYLISNYPHLISEERTRELEEIMDKIENGEVDYLEVLKALHEEILSIK
(296) DNA topoisomerase 1 [Methanococcus voltae A3]
3
MTGLIICEKPNVAKKIADALGKPKKKSQSKVPYYEVDTKGKTYYVASAVGHLYTLIEKNKTKFGDYPTYDIDWAPASTVEGKEYVQKYINVLKKLSKDANEYYVATDWDIEGELIGYHALHHACGQDIAKRMRFSSLTKKEILKSFENTDSIDFGLVDAGDSRHKIDWFFGINISRALMQAISSAKRWKTMSTGRVQGPALAFLVEKELEIQKFVPVPYWVINANLKNENENNEVPLIATHEIDKFWDEEEANKAYGNVEGQKEAIVEEIKKTKKKIKPYPPFDLGALQREAHNAFRYSPKRTQEIAQKLYEKGYCSYPRTSSQKLPKDMEYMNEVLGKLLKSKEYGKYASEILEKNLKPIEGKKDDPAHPAIHPVDVPKEALPDDEQKLYNLIARRALAAYWDDAEREYSKITVDINGEKFKLSGSRTTHEGWHEIYYFTKFDENELPELKKGKVLPIESTEKLAKETKPPKRYTMASIIKELENRHLGTKATRADILEKLTKRGYVIEDGSLSVTELGIGVIETLKKYCPEIVEETLTRDLEDKLEKIQDHKIKKEQVIDETKVKLSQILDEFRKKEKEIGKELVEKIDSTNRSLQLIGKCKCGGDLIIIKYKGKSRFVGCSNYPDCDITYPLPQKGAIKVPNKVCEVCGLPIINYMGKDLCVNIECSSRISEEDKKILEKIENEKEEEKICPKCGGTLTIKRGAFGVFRGCSNYPECKYTENLKGESNEKEIVGKCPKCGSDLVKRKGRFGEFIGCSNYPKCRHTEKILKEGEEGKEPKKATKKTTTKKTATKKTTTKKTATKKTTTKKTATKKTTKKTPAKKKE
(802) Reverse gyrase [Thermococcus onnurineus NA1]
6
MKAVYREMCPNCLGRISDERLCLKNPCNECLDETAHADSYFELITAVRNALQLKGTLKEWERIYELESGVREVEAFFENATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMALWHATKGKKSYIVVPTTPLVIQTVKKIQAIAEKSGVQINLAYYHGNLRKKEKEEMLAKIENDDYQILVTSAQWLARNFDEKLKGRRFDFIFVDDVDAFLKASKNIDRSLLLLGFTEEVINKAWEIIRLKKSMAKYINGRAEDRDERLKELNREIEKLQREIEEFKEKNGVGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLMPTKDIKEHVEELLTRLGKGGIIFTPIDQGLAYAEELVNYLRGKGFRIELVSSKNKKAIERFEKGEADYLIGSATYYGSLVRGLDMPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLTEVMDFLNDEQRREAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIDNSFHNHVLNVFRELVEFLRKVLRDEEVLRKLAEDPFISLKEEGGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFTEFKMTPFEELNLDEILRQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGNRMLTILASGGHMFDLVTNEGYHGVLIEEKDDMLKFIPVYDTIKRCRDCGHQFVDWEEKGICPRCGSTNVRDALENVKAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILRAIEEAREVNEGRVNAQLVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFTESETYFLGLTLENELSVTIELGKDAKEVEPPEEVLVEDVSLEERELNPAPPYTTDAMLKDASTFLKLSASETMRLAQDLFELGLITYHRTDSTHVSNTGIEVAKEYITQEVGEEYFRPRPWGEEGTHEAIRPTRPIDTGRLMQLIRDGIIQLSKNLTRNHYRLYDMIFKRFMTSQMKSAKVLYEKAIIDAKVGKAEIEGYVEVIEDGWTKLRSPPMRQLPRLEKGVSLKVVEAKKWKAPKVPLYTQGDIIALMKERKIGRPSTYAKIVQTLLQRYYVIETRGRKKLVPTDQGIKVYHYLISKYKELVGEEKTRELEEIMDMIEENKTDYQEVLRGLYSEIREYLK
(930) DNA topoisomerase 1 [Thermococcus onnurineus NA1]
3
MVTLIIAEKPNVARKIAYALAEGRPVRKTIGKVPYYEFTRDGKRIIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNLESTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMVLEKNGQQYTAVYEKERILDENEAKRIVEEAKKGPAFVEKVDVKQQNRHPPVPFDLGTLQREAYSAFGYSPKKTLELAQKLYERGLTSYPRTSSQKLPKNLNFRSILQNLAKLPEYKPFAHELLGKERLKPVEGKKDDPAHPAIYPTGELPKPGELTKDEANLYDLIVRRFLALFMEPAVREIMKVIINSNGHRFILSGARTIKEGWLKVYGKYVKFDEAILPAFKEGEPVKVLQIKREKKKTKPPARYSPAAVIKRMEDLGIGTKATRAQILETLYSRGYIEGKKKIKVTPLGMRVVEALERNVPDIVSVELTRAFEEKMEEIMAGKADKDRVIEESKEQLIKILQQFKEKELDIGKVLMETTGTGVTTSKENAKRAGTVKELSETEEKDVKKTIEKGEKTPLVVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLLQRGRIIPTNKTCCDGAPVVKIREKGREYEICLDMNCKDWKKGKK
(608) Reverse gyrase [Sulfolobus islandicus Y.N.15.51]
6
MTSIDKVPPSIYTRSCPNCGGNVSSQRLFNGSACESCLKEDKEFNNLSDLINILSENNTLKNLNQLYNILEEYKEVEEIFSKLLNSSKPIGPQRSWIIRFLRGESFAIIAPPGLGKTTFGLIMSLYNATRNRKSIIIFPTRTLISQTVDKLAKFSESYSYSPRILYNKQSSTQTENVLEQLKSGDFDIFVSTSRYVIQNLSELSNVKFDFIFVDDVDVALKSGKSAKAILRLVGFTDEDIQTTMKLLRENIGDEEKFGKIQEIRENKLKDKIVIFSSATISRGNPTLSSLMGFRPGSSVIYLRNIYDSYIDLTQTCKERDVDECTLGTVIRVLKRLNDGTLIFVPIDKGVQYAEYLASNLRDHGINAESVASSSISKLEKFERGEVGSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIGEYMHPLALTRLLNLVYLVKNDDKIRGLLSYIRKRLRRISPAALAMLAKDIREGKIDDERLKEAYSLVNEYLKDTEFLKKISAVGDLVIEGDYILMPDYLTYIQASGRTSRLYGANLTTGLSVLLIDNLRLFELLNKKLNLILDEVKWYPLDIDADRLGQVSLSDIVTKITEERENLSKMKKEGRVESSAINVKTTLFIVESPNKAKTISNFFSRPSTRSYGKLRVYETVLGDRILIVAASGGHIYDLITEDDNERYDGNYVYGVLVKDNKFVPIYSTIKKCEKGHQIVKDLSENKCPICGSKIVADKTEVVDILRKLALEADEVLIGTDPDTEGEKISWDIYLAIRPFNSNIKRAEFHEVTRRAILNAIKNPREFNDNLVKSQIVRRIEDRWIGFKLSRKLQTEFWEQHCKSISKENTECKENRNLSAGRVQTPVLDWIVNRYQKYNENKKKYLIIESQDKSVFPFSILASKKNGLSKKTQLFIQIVDINTKEEDFGPLPPYTTDTLLTDAANLLRIPASETMRIAQDLFELGLITYHRTDSTRISNVGISVAESYLKSKQVDISKVFRPRSWGEGGAHEAIRPTKPLDETMLKASIEQGDLELSKQLTFNHFRVYNLIFRRFITSQLPPLIVTKQIVKIKAYTDDNTELDLDEGKKEFVIGYRLKEGDEFRQVLQEAIYTTFKPYQPIDEKMKGKELIGKVTSTLNKSDVQLYTEGELISEMKSKQIGRPSTYAVIISTLKKRRYIIESKNLKKIIPTKLGMAVKEYLMEKYKQVVSEKRTVKLLEKMNEVEEGKVDYLVLLKELYNEIQTIS
(973) DNA topoisomerase [Sulfolobus islandicus Y.N.15.51]
3
MNLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVNYWIIKDHDNNKYVIVPAAGHLFGLQGKSGFPVYDVDWKPLWEIDKNSYYTKRYYQLISSLSKYALGFINACDYDIEGSVIGYLIIKYLGDTKKAKRMKFSALTKSDILLAFRNVSTLDYDMINAGVARHKIDWLWGINVSRALMISLQDFAKKRVILSAGRVQSPTLVQVVSSEIERNLFIPLPKFTVSVIVKIKDYSLNIKINKEFEKLAEANEFLNRLINKTVKVTQVENKIRILERPPPFNLTDLQVEAGRIYGISPYNVERIAEDLYLDGLISYPRTNSQKIPSTINIYNIIKGLENSSYRKLVNLVRKITGGKYIVRQGVKDDPAHPAIHPTGESPKNLPNNKFKIYDLIARRFLASVSADAKLSNTIYTLKVADFPLEFSVSYTKIPERNWLDIYHFHNVREDNPILLSKGDEGIISDGKVNISLSKPTSRYTKVSLLKWMESSDLGTEATRGRIIEILVKRRYLTSNGRYIVPTKLGFYIAELLNKFFPDIVDVRMTADMENKLEMIKTGKILESEVIKENIEKLNKFIEEYKANKDRVGESLAKALGLIKIVKCKFCDLEQYKDGLCKYHYEAKTKLLDAVRIWEERTKYDHKKILKRISSSKSTGKYVKDIVTYMLNMNDESHANLKR
(1701) Reverse gyrase [Sulfolobus islandicus Y.N.15.51]
6
MINVMYKNSCPNCGGDISADRLLNGLPCETCLPYINGIDGVDIISKVKALYNILLNNDKIKNYWNLYYNITTFEIVFKYFKDKTGYEPWSLQKLWLRRLVSNQSFTMSAPTGLGKTTTLMTYSVFIGQDVVYIVPTKSLMEQVCKRLEKLGAQVSCGKVDQRKVSVITISYLNKNANSITSYKPNFVAIDDADAVIKSGKTTGRLVSLLGIPNDVYESAIQLIRLRNKYYFSNEFTEEIKEKIRELELKIAEFKDKISQLVIASATIRPKGIKQKALRLLTGFEPSSIQLYARNIIDTYTDNLDLSIVKELGSGGLILVSKEYGRSRLNEIKKYVEDLGFNAKLAISGRKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIKAKLFDALSNPFTLLRVGKMIGVNFSELQNKILVLSPSETQLLKFSIIKGETINYQKLDQLRQELLYYISLVKDKLKEIGEETLISDNFVITKQNTNYYIIYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDKHIFEILKKKMQKLFPNTNFTSLSNINLSEIKTKLEESRKEEGNRVHFNISTGLLIVESPTKAKTIAKMFSRPSVRVINKVPVYETIIVDGNQIYVLDVVASKGHIVDLTLEDIGYYGIKVEDSGIIKPYYDLIKKCLDCNKTFSITSDKCPYCGSTNVQTAQTTINLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVYRITYHEITKKAILEALRNPMKINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVDKTMKYKSSMGYVVYIDIAGYSIKMYFSERKKMEEYINNLQVVKIEKISEEKILLSPLPPFTTDTLLIEANMKYKLSANLVMKIAQDLFEAGLITYHRTDSTHISSVGIEIAKEYLQKQGLIKDFVPKSWESSEEGAHEAIRPTRAMDVNELIQEIEENPYKYSIRFSKLHFLIYDLIFRRFMASQMSHAVGTKSRYLIKLNKDDNINTELLSNAEGGFIKVYPVKVYNLPLGEVKPKVNTGKGSSEQLLSYSDVISLMKSKGIGRPSTYAKTIENLVRHGYIVSSKRKSYLIATNRGISAYQFLSSKFYDLVSEGTTAKLMSKLDDIALSKLSASTVLLEIFSEISTLVNPLKSEQNV
Family distribution
Taxonomy tree
Archaea