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Taxon : Thermococcales
Informations
Name
Thermococcales
Rank
order
# topoisomerases
27
Lineage and sub-taxa
Lineage
Archaea
>
Euryarchaeota
>
Thermococci
>
Thermococcales
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(1799) DNA topoisomerase 1 [Thermococcus gammatolerans EJ3]
3
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVSYYEFTRDGKKVIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKNYAKDYIKALATLAKRADEFIVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNLEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVEREKEIQNFKPKPYWVIKMILEKNNSQYTATYEKDKIWDEEEAKRIVSEAKKGPAFVEKVEVKQQKRNPPVPFDLGTLQREAYSAFGYSPKKTLELAQRLYERGLSSYPRTSSQKLPKNLNFRSILQNIAKLPEYKPFAHELLGKGTFKPVEGKKEDPAHPAIYPTGELPKPGELTKDEQNLYDLIVRRFLALFMEPAVRESMRVIINSNGHRFILSGARTLKEGWLKVYGKYVKFDEVILPQFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIKVTPLGMRVVEALEKNVPDIVSVELTRAFEEKMEEIMAGKAKRDEVIEESKEQLIKILKVFKEKELDIGKMLLETTSKDSVKVEKSSEISGTSSRSGASKGENAKSSESSRKRLVLGKCPKCGGDLVLKYNRKTGKRFVGCSNWPKCNVTYPILQRGEVIPTGKTCCNGAPVVKIREKGREYEICLDMNCKEWKK
(488) Reverse gyrase [Thermococcus gammatolerans EJ3]
6
MKALYREMCPNCGGRISDERLYMRNPCESCLNEPIVVDSYFELVSAVRDALLKANRLKEWERIYRLESESREIEDFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMSVYYATKGKKSYIVVPTTPLVIQTIRKVQAIIERTGLDVKLAYYHGNLRKKEKEEMLAKIEGGDYDILITSAQWLARNFDEKLKGRHFDFIFVDDVDAFLKASKNIDRSLLLLGFTEEIIGKAWEIIRLKKQMARYLNGNSEDKNDRLKELNEAIEKLQREIEEFKRKNDIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPSKDVKEHVEELLRKLGKGGLIFVPIDQGLSYAEELVNYLREKGFAVELASSKNKKAVERFENGEADYLVGVATYYGSIVRGLDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLGEVMDFLDDEDRKTAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENDFHKTVLNVFRELVEFLREVLKKEDVLRRLAEDPFVSLVKEEGKWFIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFTEFKMVPFEELDLEKLLKEIDEDREKVKLVMEGKISSKVKDLVKSALMIVESPNKARTIANFFGKPSKTRIGELVAYEVSVGDKMLTILASGGHMFDLVTNEGYHGVLIEREEDMFKFIPIYDTIKRCRDCGYQFVDWEERGVCPRCGSRNVHDALENVKAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRVEFHEVTRPAIMKAIREARDVNEARVEAQMVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTVELGKDGKDVEPPEYVTVEEVQLEERELNPSPPYTTDAMLRDASTFLKLSAPETMRLAQDLFELGLITYHRSDSTHVSSTGIEIAREYITSELGEEYFKPRPWGEEGTHEAIRPTRPIDTGRLMQLIRDGVIQLPRNLTRNHYRLYDMIFRRFMTSQMVPAKVLYEKAVINAGVGKVELEGYVEILKDGWTKLRSPPMRQLPKLEQGAKLKVVESKKWKAPKVSLYTQGDIIALMKERGIGRPSTYAKIVQTLLQRYYVFETRGRKKLVPTEKGIKVYHYLVSKYRELVSEEKTRELEEKMDLIEEGKLNYLDVLNELYREITCEIKKEGCS
(270) Reverse gyrase [Pyrococcus sp. NA2]
6
MKAIYRGMCPNCGGAITDERLSSKNPCEGCLAEPIVLQDYDKLIEAIRNALKLRDTLKDWEELYRLNKEVSEVEELFERATGFRFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYFATKGKKSYIVVPTTPLVIQTVKKIKAMLERAKLNVNLVYYHGNLKKKEKEEALEKIRNGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLMLGFSEEMINKAWEIIKLKKQLAKLLQNEGKEEEVEKLNREIEKAEREIEAYKKNNNIGILIVASATGTARGDRIKLYRELLGFEVGSGRSVLRNIVDTYLIPEKSIEEHVEELLRKLGKGGLIFVPIDRGIEYAEKLTEYLKKKGFRVELVSAKSKKGIELFENEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEDKRAEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKSAVEFLRAVLKDEEVIKRIAENPFLSLKEIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVVIVDDEKVFNGLLRQMRWRFVEFEMKRFDEVDIDDVLREIDEDRKKVRMVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRKIGDLVAYEVSIGDRMLTILASGGHMFDLVTTEGYHGVLMLKRNGKPYFVPIYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIREARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLVLENGISITIENAKGNVSEVTVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSTHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPVDTGRLIQLIRDGIITLPRNLTRDHFRLYDLIFRRFIASQMKPAKVIYEEAIISTPFGDVEVEGYIDVIYDGWSRIKPLPLKKIPKLEKGQVIKVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLMSKYKPLVNEERTRQLEKIMDMVEEAKADYQDVLNELYDEIKAYVK
(1147) DNA topoisomerase 1 [Pyrococcus sp. NA2]
3
MILVIAEKPNVARKIAGALAEGRPIKRTMFGVPFYELFRDGKKVIVAPAVGHLYGLAPKQDFYGYPIFEIEWVPVYMAEKGKEYAKDYINLLSVLSRRVREFIVACDYDTEGEVIGYTALKYACKVDPKIAKRMKFSTLTKGDLIRAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWIILSTGRVQGPTLKFLVDREREIQSFVPKPYWVIKMVIEKGGKKLVATYEKDKVFDEAEAKRIVEETRKGKAIVEKVEVKRQNRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQSLYEKGYCLHPDSLILTPSGIKKIRELPEKGEVLALDFNLKLSKAKYRLLERDADEPMYRIILSDGTELYLTGDHPVLTYREGRLIFIPAEKLKENDKVVLLNGGYKDTYSLSFLLEEASMDDYIIYEKSFGEVIKTRMTNEMKEIYSYLNGKIPIPVLRFLIEKKIVSEEEIFKVFRGFSYLDSQLPINDRFWHLIGMIIAIGYKLENDNVILLPSKEITNRVIEHVEALGIPFVYDGERLVLKSKSLSRLLKIIGDKVIPPKKDWMISLIKGYQEVNGLRFRDKELAYKLKVMFQLLGVRTRLKRGTTYELVIDSEHEPEVEEGPDAPRVANGDVYILEIKSIDKFHYRGKVYDLVVEDYHNFIANGVIVHNCSYPRTSSQKLPKNLNFRFIIQNIARMPEYRPIAHELLGKEVLKPVEGKKEDPAHPAIYPTGEIPEPGELTRDEWNLYDLIVRRFLALFMEPAVRESMKVIINANGHRYILSGARTVKEGWLRAYGKYIKFDEVILPLFFRGERVRVLQVRRERKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVVETLEKYVPEIVSVELTREFEEKMELIMQGKLTKEEVIEEAKERLTKILQKFKEKELEIGIELAKIVVGEDVKLPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQKGEIIPTNKTCCNGAPVVIIREEDGREIEICLDMNCKWPKSY
(199) DNA topoisomerase 1 [Pyrococcus yayanosii CH1]
3
MILIIAEKPNVARKIASALAEGRPVKKSIYGVPYYELTRDGKRLIVAPAVGHLYGLAPKRDFFGYPIFDIEWVPVYVAEKGKEYAKDYIKALSVLAKRAKEFVVATDYDTEGEVIGYTALKYACGVDPRKAKRMKFSALTKRDLLKAWYNLEPTINFGMAGAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQNFVPKPYWIIKLILEKNGRKLTATYEKDKVWDEEEAKRIVQEARKGYAIVENIDVRRLQRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQSLYEKGYCLHPDSLIPTPDGIKKIAELPKEGEVLALDFNLKLSRARYRLLERDADELMYKVTLGDRTELYLTADHPVLVCRDDKLIFVPAEELKESDQVVLVIAREGFKGRENPPTLLDFLLENARTMKDYILYDPEFGKDLRRRLKERGLKVEVMAEFNIRESTYYNYLRGKMPVPIAKFLLDKGVISREELRSVFRGFAYSTSLSPISFEFSEEFWYLYGFVVGSSYTVKNGALVISAKEREEDIVRAIREVANSLGVPFRYDAKYKLIIIRSKSLTRLFELLGCSYGNKTRTFRIQGIVVSRPGWIAAFLAGYCDADAHIRVKPTGSRKSLSPQIVLTSKNKEVIYTIKLMWQLLGVRTYLLEKKDKNGVVYELKVYPKDVPRFYEVLRSFLIVKRKDLERVIEIVAGKRAINIEETAIPLTDEDLRRIATGDVYLLKVNGIEKFRYRGKVYDLVVEDYHNFIANGVVVHNCSYPRTSSQKLPKNLNFGAILQGLSKLPEYRPFAHMLLGKEVLKPVEGKKEDPAHPAIYPTGEVPKPGELTKDEQNLYDLIVRRFLALFMEPAVRESVKVTIKAGSHRFILSGARTVKEGWLRVYGKYVKFDEVLLPGFRRGEPVRVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVVETLEKHVPEIVSVELTREFEEKMELIMNGKLTKEAVIEEAKERLLKILEEFKRKELEIGRELAKIVIGEDLVEDKREDIVVVGKCPKCGGDLVVKYNRKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCDGTPIVIIREEDGREYEICLDIRCRKGKGR
(403) Reverse gyrase [Pyrococcus yayanosii CH1]
6
MKAIYRGMCPNCEGRISDERLSMKNPCESCLDEPVGEQVYFDLIKAVRDALKLKGTLKEWEEIYKLNKAVKDVEKFFEKATGFTFWSAQKTWVKRLVRGRSFSIIAPTGMGKSTFGAFMAIYFAQKGKKSYIVVPTTPLVIQTVRKIRTMAERAGVEVNLAYYHGNLKKKEKEDMLAKIRDGNFEILVTSSQFLATRFDELLKDKKFDFIFVDDVDAFLKASKNIDRSLILLGFTEDVIAKAWEIIKLKKQLAKLLQRGNIEDIERLNSQIERLEEEIEAFRQKNNVGVLIVASATGSARGDRIKLYRELLGFEVGSGKSVLRNVVDSYLIPEKPVEDVVAELLQKLGKGGLIFVPIDKGIEYAEKLTEFLKERGFRVELVSARSKKGLELFERGEVDHLVGVATYYGTIVRGLDLPHLIRFALFTGIPKFRFSLDLEQPTIYRVLGLMSEIIEFLPEEDRRTGEKLYSRLRKIIRNVPQFELMKIEEALAEGLPLEGFQNHVLEIFREAVEFLRRVLKNEIVLKKIAEDPFLSLKREGDKWFIEIPDVRTYIQASGRTSRLFAGGITKGLSVLIVDDEKVFNGLVRQMRWRFTEFKMIPFEELDLEEVLKEIDEDREKVKLVMEGKISAKVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGDLVAYEVSIGDRMLTILASGGHMFDLVTNEGYHGVLIQKKEGRPFFIPVYDTIKRCRDCGHQFVDWEEKGACPRCGSKNVHDALENVKAMREIAQEVDEILIGTDPDTEGEKIAWDIRNVLAPYAPVIKRIEFHEVTRPAILKALREARDVNENRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWVIQRYKEFTESETDFLNITLENGLSITLEGAKGKVGEVIVEDVQVEERDVNPLPPYTTDTMLQDASRILGFSAPYAMQLAQDLFEAGLTSYHRTDSIHVSNTGIEIAKEYITQEIGEGYFQPRPWGQEGAHEAIRPTRPIDTGRLIQLIRDGIITLPKNLTRDHFRLYDLIFRRFIASQMKAARVLYEKAIINAGLGKAEVEGYLEVLFDGWSRIKPLPLKQLPKLEPGQRIKVKELKHWRAPKVSLYTQGDLIALMKERRIGRPSTYAKIVQTLLQRGYVVETKGRKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEELMDMVEEARADYQEVLNDLYKEIQTYVR
(432) Reverse gyrase [Pyrococcus abyssi GE5]
6
MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIRS
(176) DNA topoisomerase 1 [Pyrococcus abyssi GE5]
3
MILVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDFFGYPIFDIEWVPVYIAEKNKDYAKDYIKALSVLAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPKPYWVIKLVIEKNGQKLVANYEKDKIWSEEEAKKIVTEVKKSKARVSNIEVKRQKRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTESQKLPKNLNFRLIIQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPGPGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPHKFMLSGARTVKQGWLSVYGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFERKMDLIMQGKLTKEEVIEEAKVKLTKILEEFKKRELEIGLELARIVVGDVKDEIKEEKPIVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIRDKGRDIEICLDIKCKKW
(431) Reverse gyrase [Pyrococcus abyssi GE5]
6
MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIRS
(175) DNA topoisomerase 1 [Pyrococcus abyssi GE5]
3
MILVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDFFGYPIFDIEWVPVYIAEKNKDYAKDYIKALSVLAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPKPYWVIKLVIEKNGQKLVANYEKDKIWSEEEAKKIVTEVKKSKARVSNIEVKRQKRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTESQKLPKNLNFRLIIQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPGPGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPHKFMLSGARTVKQGWLSVYGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFERKMDLIMQGKLTKEEVIEEAKVKLTKILEEFKKRELEIGLELARIVVGDVKDEIKEEKPIVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIRDKGRDIEICLDIKCKKW
(890) Reverse gyrase [Thermococcus sp. 4557]
6
MKAIYREMCPNCLGRISDERLINKNPCSECLDDTVTADSYFDLITAVRSALKLRGTLKEWERIYSLENGLREVEGFFEKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHATRGKKSYIVVPTTPLVVQTARKIRKIAENAGVEVNLAYYHGNLRKKEKEEMLAKIQNEDYGILVTSAQWMARKFDEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFNDEVIGKAWEIIRLKKQMSKYLNGRAKDREERLKELNAQIAELQRDIEEFKRENPIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVADTYLKPSKDIKEHVEDLLTMLGRGGIIFTPIDQGLGYAEELADYLRERGFRIELVSSKNRKAIERFENGEADYLIGSATYYGSLVRGLDMPHLIRYAIFTGVPKFRFSIDLERPTIYRALGLLSEVMDFLSDEDRKQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLKDEEVLRKLAEDPFISLKEEDGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLLRQMRWRFTEFKMVPFKELDLDEVLRQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEVSIGNMMLTILASGGHMFDLVTNEGYHGVLVDEKDGMLKFIPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSTNVRDALQNVKAMRELAQEVDEILIATDPDTEGEKIAWDIMNVLSPYTPNIKRIEFHEVTRPAIMRAIEEARDVNEGRVNAQIVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWVIERYKEFTESETYFMGLTLENDLRVTIELGKDGKGIEPPEYVTVEDVQLEERELKPSPPYTTDAMLKDASTFLKLSAPEAMRIAQDLFEMGLITYHRTDSTHVSNTGIEIAKEYITQELGEEYFKPRPWGEEGTHEAIRPTRPIDTGRLMQLIRDGILQLPKNLTRNHYRLYDMIFKKFMTSQMKAARIIHERAVIDAGIGKTEVEGYVEVVEDGWTRLRSPPMRQLPMLEKGARLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVQTLLQRYYAIETRGRKKLVPTDQGIKVYHYLISKYKDLVNEEKTRGLEEMMDRIEEGSVDYQEVLNALYRELQGYLGNGKPQ
(1327) DNA topoisomerase 1 [Thermococcus sp. 4557]
3
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVGYYEFTRDGKRIIVAPAVGHLFSLAPKVKTYGYPIFDIEWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVIGYTALKYACGIDPSRAKRMKFSALTKKDLLKAWYNLEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWQVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMLLEKNGEQYTAVYEKERILDEDEAKRIVEEAKKGPAFVEKVEVKQQKRNPPVPFDLGTLQREAYSAFGYSPKKTLELAQKLYERGLTSYPRTSSQKLPKNLNFRPILQNLAKLPEYKPFAHELLGKERLKPVEGKKEDPAHPAIYPTGELPKPGDLTKDEQNLYDLIVRRFLALFMEPAVREIMKVVINSNSHRFILGGARTVKEGWLKVYGKYVKFDEVILPAFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKRMEDLGIGTKATRAQILETLYSRGYIEGKRKIKVTPLGMRVVEALEKNVPDIVSVELTKAFEEKMAEIMAGKADREDVIEESKNQLIKILKVFKEKELDIGKMLMETTGTGATTSKTAARKAGAVKELSGEEEKAVKKAVDGGERRKEPLVLGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLLQRGEIIPTDKTCCGGAPVVKIREKGREYEICVDMNCRDWKKGKK
(846) Reverse gyrase [Thermococcus barophilus MP]
6
MKAIYREMCPNCEDRISDERLYKKHPCDVCLDREIQAEIYFDLITGIREALKLRRTLKHWENIYKLEKKLREIEDLFEKATGFNFWSAQKTWVKRLIKNKSFSIIAPTGMGKSVFGSFMALYYAKKKKKSYIVLPTTPLVVQTIKRVKTFAERAGIEINLAYYHGGMKKKEKEEMTEKIMSGDFDILITSAQWLARNFDEMLKDKRFDFIFVDDVDAFLKASKNIDRSLILLGFTEEIIQKAWEIIRLKKQMAKFLNGNSPDKQEQLKELNKQINKLEREIRKFKRENKIGVLIVASATGSARGDRIKLYRELLDFEVGSGRSALRNVVDSYLFPEKSIEEHVEELLTKLGKGGLIFVPIDQGISYAEKLTQYLQEKGFKVELVSARNKKGLEKFENEEIDYLVGVATYYGTIVRGLDLPHLIRYAIFTGVPKFRFSLDLEQPTIYRVLGLMSEVMEFLDEEDRREGERLYARLRRLIRNIPQFELMKIEEALAEGLPLEGFHSHVLEVFKQSVEFLRRVLKKEEVLKRIEEDPFVSLKEEEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDNEKVFNGLKRQMRWRFAEFEMKPFEELNLEELLREIDSDREKVRLILAGKISEKTKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDRMLTILASGGHMFDLVTTEGYHGVLIEERDGKLYFIPVYDTIKRCRDCGHQFVDWEERGVCPRCGSRNVRDALENVIAMREIAQEVDEILIGTDPDVEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKALNEARDVNEFRVNAQLVRRIEDRWIGFELSQKLWEVFESRNLSAGRVQTPVLGWVIQRYKEFVESETDFMALTLENGLSVTLEGVKDEVNEIIVEDVQIEEKEINPFPPYTTDTMLQDASRFLGFSAPHTMQLAQDLFELGLITYHRTDSTHVSNTGIEVAKEYISEEIGEEYFAPRKWGEEGAHECIRPTRPIDTGRLMQLLRDGIITLARGLTRDHFRLYDMIFKRFMASQMKAAKVLYEKAVIDARIAKTEIEGYVEIIFDGWTKLRAPPLKQLPRLEKGQKLKVIEVKKWRAPKVSLYTQGDLIALMKERKIGRPSTYAKIVKTLLDRHYVIETKGRKKLVPTELGTKVYHYLISKYKELVSEERTRQLEELMDLVEENKADYQEVLSNMYEEIKQYILK
(899) DNA topoisomerase 1 [Thermococcus barophilus MP]
3
MVTLIIAEKPNVAKKIAYALAERKPIRKTLYGVPYYELSRDGKKIIVAPAVGHLYTLAPKTKTYGYPIFDIEWVPVYVAEKGKSYAKDYIKALRELAKRADEFIVACDYDTEGEVIGYTALKYACGVDPKKAKRMKFSALTKRDILKAWYNLEPTINFGMADAGIARHILDWYWGVNLSRALTHAIKRASGKWMILSTGRVQGPTLKFLVEREKEIANFKPTPYWVIKMTLEKNGKQYTATYEKERILDEEEAKRIVQEAKKGPAFVEKVEVKQQKRNPPHPFDLGTLQREAYSAFGYSPKKTLDIAQRLYEMGICSYPRTSSQKLPKNLNYKYIIQSLAKIPEYKPFAHELLGKPQLKPVEGQKDDPAHPAIYPTGELPKPGELTQEEKNIYDLIVRRFLAAFADPAVREIMKVIINSNNHHFILSGARTVKEGWLKIYGKYVSFDEVILPKFREGEPVKVIQIKREKKKTKPPARYSPASVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIRVTPLGMKVVEALEKNVPEIVSVELTREFEEKMDEIMKRKLSKDRVIEEARGQLIKILREFKAKELDIGKELMEKLLEREKNKKSKKKTAKELTAEEEEAIKNAVENHEKKSNNLIIVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPSCDVTYPLLQRGKIIPTGKVCPECNAPVVKIKEGKKEYEVCLDMKCKKKMDKNKY
(726) Reverse gyrase [Thermococcus sibiricus MM 739]
6
MKAIYKGMCPNCEDKISDERLYKKHPCEICLEDEITSDTYFDLISGIREGLRVRNRIKQWEGVYSLEKKLIEAETLFKNATGFTFWSAQKTWVKRLVKGKSFSIIAPTGMGKSVFGAFMSIYYAKYGKKSYIILPTTPLVTQTIKRVKTFAENTGIDVNLAYYHGNMKKKEKEEMIQKIQTGDFDILITSGQYLARNFDLIKDKKFDFIFVDDVDAFLKASKNIDRSLILLGFNEEMIQKAWEIIKLKKLMAKYLNGNRKDKNEQLKELNKQINIIEKEIREFKDKNKIGVLIIASATGSARGDRIKLYRELLDFEVGSGRSALRNVVDSYLFPENSIEEHVKELLKVLGPGGLIFVPIDQGIAYAERLTNYLQDLGFKVELISARNKKGLQRFENGEVDYLVGVATYYGSIVRGLDIPHLIRYAIFTGIPKFRFSIDLEQPTIYRVLGLMSEVMDFLENEDRKNAEKLHAQIRRLIRNIPQFEILKIEEALAEGLPLEGFSNHVLKVFKEAVQFLRMILKKEDVLKRIEEDPFISLKKEENKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVIIVDNEKVFNGLKRQMRWRFAEFEMRPFHELELEKLLQEIDADREKVKFLLEGKIAEKTKDLVKSALMIVESPNKARTIANFFGHPSKRRIGDLVAYEVSIGELMLTILASGGHMFDLITNDNYHGVLIKEKEGKLYFIPIYDTLKRCRECGHQFVDWESKGVCPRCGSNDVRDVLENVKAMREIAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPTIKRIEFHEVTRPAILKALKEARDINEGRVNAQIVRRIEDRWIGFELSQKLWEVFENPYLSAGRVQTPVLSWIIQRYKEFVESEINFVQLTLENDLSVVLEDVKDGVEEVVVEDVHLEEKEINPLPPYTTDTMLQDASRFLKFSTDYTMRLAQDLFEVGLLTYIRTDSTHVSNVGIEVAKEYITDEIGEEYFVPRKWGEEGTHECIRPTRPIDTGRLMQLLRDGVITLARGLTRDHFRLYDMVFKRFMTSQMKATKVLYEKATIDARIAKAEVEGYVEILYEGWTKLRNLPLKKLPKLEKGQKIKVKETKKWKAPKVPLFSQGDIIALMKEHKIGRPSTYAKIVKTLLDRHYVIETKGRKKLVPTELGTKVYHYLITKYKDLVSEERTKQLEELMGLIEEDKIDYQEVLTELYKEIKKYTA
(1579) DNA topoisomerase 1 [Thermococcus sibiricus MM 739]
3
MTTLIIAEKPNVAKKIAYALAERKPIRKTIGKVPYYELTRDGKKIIVAPAVGHLFSLAPKERTYGYPVFDIDWVPVYLAEKGKSYTKDYIKALKELAKQADEFVIACDYDTEGEVIGYTALKYACGVEPSKAKRMKFSALTKQDLLRAWYNLEPTINFGMADAGITRHILDWYWGVNLSRALSSAIRKSSGKWHVLSTGRVQGPTLKFLVDREKEIENFVPTPYWVIKMILEKNGEQYTANYEKDRILNEEEAKRIVEEAKKGPAFVEKIEITQQKRSPPYPFDLGTLQRESYSAFGYSPKKTLEIAQKLYEKGYCLHPDSLIPTPKGVKKIEELPKEGEVFALDFDLKLSRARYRLLERDADELMYKVTLSDRTELYLTGDHPVLAYRDDRLIFVPAEELKDDDQVVLLINPWKFQSASETPKLFDFILKNASSMKDYILYDQSFGSVIRNRIKKAGLKVEILWKFKIKEPTYYKYLRGKMPVPVFKFLIERGVISKEEAREVFKGFSYSTSLSAVSFEFNEDFWYLYGFVVGDCHLDKRGQITIGARDRTEETIMAIQEVANSIGVRFAYDSRYKIIRLGSKSLVRLFELLGCPYGNKMKIFEIPGEVMAKPGWMASFLAGYYDADSHIGTKSTGGRKSLSPQIVLTSKNRRAIYTVKLMWQLLGVGTYLWERKDKNGNLMAYELKVYSRDSLKFYEIMKDHLRVKRCDLEKVRNAAIRKRKSYSHHYSVLKVTDWNGKLKSNKKLWKEFDISNQTAHGRGISLDKLRRIRDYLTDEDLRRIATGDVYILGIKSIEKFHYCGKVYDLVVEDYHNFIANGVVVHNCSYPRTSSQKLPKNLNFRSIIQNLAKIPEYKPHAHELLGKGILKPVEGKKDDPAHPAIYPTGEVPKPGDLNKDEQNLYDLIVRRFLAAFAEPAIRESMKIIINSNKHHFILNGSRTIKEGWLKIYGKYVKFDEVILPKFEKGEKVNVIQIKKEKKKTKPPARYSPASIIKKMEDLGIGTKATRAQILETLYSRGYIEGKKKIKVTPLGIKVIEALENNVPDIISVELTREFEQKMEEIMARKLKKERVIEESKTALIKVLKEFKNKEGEIGKKLLETFLENEKNKKSKRKNVKELKPEEEKVIQVEADFENKGKEKIIVGSCPKCGGDLVVRYNRRTGKRFVGCSNWPNCNVTYPLLQRGQIIPTGKTCSECGNAPIIKIKERNREYEVCLDMNCNKNRKKK
(362) DNA topoisomerase 1 [Pyrococcus horikoshii OT3]
3
MILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKRDVFGYPIFDIEWVPVYIAEKGKEYAREYIKALSVLAKRVREFIVACDYDTEGEVIGYTALKYACGVDPRVAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKLIFEKNGQKFTANYEKDKIWEEEEGKRIVLEVKKSIPRVSNVEIKRQKRTPPHPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFSSYPRTESQKLPRNINFRMIIQNLAKMPQYRPYAHILLGLPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEEKLYDMIVRRFLAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVKKGWLSVYGKYVKFEEVTLPEFFIGERIKVIQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGRLTKEEVIEEAKERLTKILEEFKKRELEIGIELAKIVVGEDEVKPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIREEDGREFEICLDINCKDWKAKSH
(544) Reverse gyrase [Pyrococcus horikoshii OT3]
6
MKAIYRGMCPNCRGAITDERLSNKNPCEGCLSEPILSEDYNELIVAVRNALKLRGTLKDWEELYRLNKEVSEIEELFEKSTGFKFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYFATKGKKSYIVVPTTPLVIQTVKKIESMLEKANVSVRLVYYHGNLRKKEKEEALEKIRNGDFDILITSSQFLATRFKELLKDKKFDLIFVDDVDAFLKASKNIDRSLIMLGFSEEIIGRAWEVIKLKKQLAKLLQNEKKNEEEIEKLNKEIEKIEDEIEEYKRRNKIGILIVASATGSAKGDRIKLYRELLGFEVGSGRSVLRNIVDTYLLPEKPIEEHVVELLRKLGKGGLIFVPIDKGIEYAEELTDYLKSQGFKVELVSAKNKKGLELFEKGEIDYLVGVATYYGTLVRGLDLPHLIRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEEKKSEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFHNHVLEVFKQSVEFLREVLKDEEVIKKIAENPFLSLKEIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFDIKKFEEVNLKEVLKEIDRDREKVKLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRKIGDLTAYEVSIGDKMLTILASGGHMFDLVTNEGYHGVLILKNNGKPYFVPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLAPYAPNIKRIEFHEVTRPAILRAIREARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGIILENGINVTIENAKGEVREVEVKDVIIEEKDVNPLPPYTTDTMLQDASRFLGFSATKTMQLAQDLFEAGLCVTPDTLVSLSDGRIIEIREAVENSEESLLGINGLKPKEAKALKFWEIDWDGPIKVIKLKNGHEIKATPDHGLLVMRDGKIGWVSAKNIREGDYVAFIYNLGHRGGKKYTLPQLLKELGISEYENSSSQELNNREQEMDSKQISIELDERFWYIFGVILGKGTLKGDKVVIFQKDVKPVIEEALPFVRIFESADHIGFSHLILAEVFRRLGVGEGKLHSLVFGLREEYINAMIAGYFDASGTFLRRAVLTSKRGDILRMLSVYLYQIGIVNNLRRDEHAGVWELIISDLEKFREKIYPYLRIKKSQFDKVYSISKNEGDFLPVASIFRKLKFRDGFKNRILDEEIPRDEVAKVLEYAEDSPEKEFLNSLVEARVTWVRVEKIEERHYTGKLYDFTTTTENFISNGIVSHNCTYHRTDSIHVSNTGIEVAKEYITQEIGEEYFTPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITIPKNLTRDHFRLYDLIFRRFMASQMKPAKILYEKAIISTPFKDVEVEGYIDVLYDGWSKIKSLPLRQIPKLEKGQRLRVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLITKYKDLVSEERTRQLEKIMDMVEEAKADYQDVLNELYEEIKRYVR
(117) DNA topoisomerase 1 [Thermococcus kodakarensis KOD1]
3
MVTLIIAEKPNVARKIAYALAEGKPVRKTIGKVSYYEFTRDGKKVIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKQADEFVVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNMEPTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVEREKEIQNFEPKPYWVIKMLLEKNGGQYTAVYEKEKVWDEEEAKKIVEEAKKGPAFVEKVEVKQQNRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQKLYEKGYCLHPDSLIPTPQGVKRIKELPEKGEVFALDFDLKLSRARYRLLERDADEPMYKVTLSDRTELYLTADHPVLVYRDDQLIFVPAEELRENDQVVLFINRSEYSPRTESPTLLGFLLENATSMKDYILYDPEFGGVLRNRIKDAGLKTEILWRFRIREPTYYKYLRGKMPVPIVRFLLEEGVVSIEELREVFRGFSYSTSLTPISFEFSEEFWYLFGLVAGDGHLAKKGAITIPAKDRTEDTVKAVKEIANSLQVPFAFDEKYKMIILRSKSLTRLFELLGCPYGNKTEIFRIPGEIMAKPEWMAAFLAGYYDADGHIGTKPTGGKKSHSPQIVLTSKNRMAIYTVKQMWQLLGVGTYLWEKKDRNGNFMAYELKVYSRDAWRFYEVMKNHLRIKRKDLEHVKEVAIRKRKAYSHHYSVLNVKSWEGKIKSSNVLWKKFDMSNQTAHGRGISLDKLQRIVDYLTDTDLRRIAMGDVYVLGIRSIEKFHYRGKVYDLVVDQYHNFIANGVVVHNCSYPRTSSQKLPKNLNFRSIIQNLAKLPEYKPFAHELLGKESLKPVEGKKDDPAHPAIYPTGELPKPGELTKDEGNLYDLIVRRFLALFMEPAVRETMKVVINSNNHRFILSGARTLKEGWLKVYGKYVKFDEVILPAFKEGEPVKVIQIKREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKKIKVTPLGMRVVEALEKNVPDIVSVELTRAFEEKMEEIMAGKADKDQVIEESKEQLIKILQVFKEKELDIGKMLLESTGTGVTTSKEAAKKTGAVKDANDEEKSDGKAGEGTTPKAERKPLVVGKCPKCGGDLVIRYNRKTGKRFVGCSNWPKCDVTYPILQRGQVIPTEKTCCNGAPVVKIREKGREYEICLDMNCKDWKKK
(382) Reverse gyrase [Thermococcus kodakarensis KOD1]
6
MKAVYREMCPNCWGRISDERLVMRNPCEECLDEPVHADSYFQLVSAVRNALKLRGTLKEWEKIYQLENQTREIEEFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHALKGKKSYIVVPTTPLVIQTVRKIEGIMENANADVRLAYYHGNLRKKEKEEMLERIKNEDYDILVTSAQWLARNYEEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFTDEIIQKAWEIIRLKKQMSRYLNGNSEDRNEKLNGLNREIEKLQREIEKFKRKNKIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTKDIKEHVEELLTRLGKGGLIFVPVDQGLGYAEELANYLSEKGFKIELVSSKNKKALEKFENGEADYLIGSATYYGSLVRGIDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSEEDRRQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLRDEEVLRKLAEDPFISLVKEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEFKMVPFEELDLDEILRQIDEDREKVRLVMEGKISAKVKDLVRSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEISVGDRMLTILASGGHMFDLVTNEGYHGVLIQNEGDMLKFIPVYDTLKRCRDCGHQFVDWEKKGVCPRCGSTNVRDALENVIAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRIEFHEVTRPAIMKAIQEARDVNENRVNAQIVRRIEDRWIGFELSQELQRVFESYNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTIELGKDGKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTLVSLADGRIMEIKDAVEKSEGNLLSVNGLKPKEAKALKFWEIDWNGPLKVIKLKNGHEIKATPDHGLLVMREGKLGWVSAKNVREGDYVAFAYNTGHRGRDEYTLLKLMIKLGITDVMVELDEEYFNEKVAPIVRERISTSTKYKYLRRRVLPLYLLQEWGLDDYEAHVKSLYRQRAGSKPIPNFKLDGRFWYVFGLVLGDGTLRDSKVLISQTPLKDVKSVLEDVFPFLRVFETTNQVGFSNSIIAEVFRRLGARKGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNDRKGPNFRGILTSKRGDVLRMLSVYLYQIGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYLRIRRAQFDEAYSVYRASRRAFEGDLLPVAPVFGKLKFKNGTKNRILKETGIDVWNWLKRPEGEIPRDKLSKVLEYAEESPEKEFLKSLVEAGVTWVKVKGVEEELYTGKLYDFTTTTENFLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPRPWGEEGAHEAIRPTRPIDTGRLMQLIRDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKAELEGYVEIIEDGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVETLMRRGYVVETKGRKKLLPTEKGIKVYHYLVSKYRDLVSEERTRELEEIMDRIEEGIEDYIKVLGELYSEIQRYVSG
(381) Reverse gyrase [Thermococcus kodakarensis KOD1]
6
MKAVYREMCPNCWGRISDERLVMRNPCEECLDEPVHADSYFQLVSAVRNALKLRGTLKEWEKIYQLENQTREIEEFFKKATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMAVWHALKGKKSYIVVPTTPLVIQTVRKIEGIMENANADVRLAYYHGNLRKKEKEEMLERIKNEDYDILVTSAQWLARNYEEVLKGRHFDFIFVDDVDAFLKASKNIDRSLYLLGFTDEIIQKAWEIIRLKKQMSRYLNGNSEDRNEKLNGLNREIEKLQREIEKFKRKNKIGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLKPTKDIKEHVEELLTRLGKGGLIFVPVDQGLGYAEELANYLSEKGFKIELVSSKNKKALEKFENGEADYLIGSATYYGSLVRGIDLPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLSEIMDFLSEEDRRQAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIENEFHNHVLGVFRELVEFLRRVLRDEEVLRKLAEDPFISLVKEEGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFQEFKMVPFEELDLDEILRQIDEDREKVRLVMEGKISAKVKDLVRSALMIVESPNKARTIANFFGQPSKTRIGDLVAYEISVGDRMLTILASGGHMFDLVTNEGYHGVLIQNEGDMLKFIPVYDTLKRCRDCGHQFVDWEKKGVCPRCGSTNVRDALENVIAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLAPYTPNIKRIEFHEVTRPAIMKAIQEARDVNENRVNAQIVRRIEDRWIGFELSQELQRVFESYNLSAGRVQTPVLGWIIERYKEFTESEVYFLGLTLENGLQVTIELGKDGKDVEPPEYVTVEEVQLEERELNPAPPYTTDAMLKDASTFLKLSAPETMRLAQDLFEAGLCVTPDTLVSLADGRIMEIKDAVEKSEGNLLSVNGLKPKEAKALKFWEIDWNGPLKVIKLKNGHEIKATPDHGLLVMREGKLGWVSAKNVREGDYVAFAYNTGHRGRDEYTLLKLMIKLGITDVMVELDEEYFNEKVAPIVRERISTSTKYKYLRRRVLPLYLLQEWGLDDYEAHVKSLYRQRAGSKPIPNFKLDGRFWYVFGLVLGDGTLRDSKVLISQTPLKDVKSVLEDVFPFLRVFETTNQVGFSNSIIAEVFRRLGARKGKLHPLVFGLREEYINAMIAGYFDTDGTFSILNDRKGPNFRGILTSKRGDVLRMLSVYLYQIGIMNYLRRDERTGVWDLIISNRSLEKFREKIYPYLRIRRAQFDEAYSVYRASRRAFEGDLLPVAPVFGKLKFKNGTKNRILKETGIDVWNWLKRPEGEIPRDKLSKVLEYAEESPEKEFLKSLVEAGVTWVKVKGVEEELYTGKLYDFTTTTENFLSNGAVSHNCTYHRTDSTHVSNTGIEVAKEYITQELGEKYFKPRPWGEEGAHEAIRPTRPIDTGRLMQLIRDGIIQLPRNLTRNHYRLYDMIFRRFMTSQMTPAKILYEKAVINAGVGKAELEGYVEIIEDGWTRLRSPPLRELPKLEKGMKLKVVEAKKWKAPKVSLYTQGDIIALMKERKIGRPSTYAKIVETLMRRGYVVETKGRKKLLPTEKGIKVYHYLVSKYRDLVSEERTRELEEIMDRIEEGIEDYIKVLGELYSEIQRYVSG
(1203) DNA topoisomerase 1 [Pyrococcus furiosus DSM 3638]
3
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTANYEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELWYLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLELAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
(1220) Reverse gyrase [Pyrococcus furiosus DSM 3638]
6
MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS
(1204) DNA topoisomerase 1 [Pyrococcus furiosus DSM 3638]
3
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTANYEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELWYLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLELAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
(1219) Reverse gyrase [Pyrococcus furiosus DSM 3638]
6
MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS
(802) Reverse gyrase [Thermococcus onnurineus NA1]
6
MKAVYREMCPNCLGRISDERLCLKNPCNECLDETAHADSYFELITAVRNALQLKGTLKEWERIYELESGVREVEAFFENATGFTFWSAQRTWVKRLLKGRSFSIIAPTGMGKSTFGAFMALWHATKGKKSYIVVPTTPLVIQTVKKIQAIAEKSGVQINLAYYHGNLRKKEKEEMLAKIENDDYQILVTSAQWLARNFDEKLKGRRFDFIFVDDVDAFLKASKNIDRSLLLLGFTEEVINKAWEIIRLKKSMAKYINGRAEDRDERLKELNREIEKLQREIEEFKEKNGVGIMIIASATGSARGDRIKLYRELLGFEVGSGRSALRNVVDSYLMPTKDIKEHVEELLTRLGKGGIIFTPIDQGLAYAEELVNYLRGKGFRIELVSSKNKKAIERFEKGEADYLIGSATYYGSLVRGLDMPHLIRYAVFTGVPKFRFSIDLERPTIYRALGLLTEVMDFLNDEQRREAEKLHARLRRLIRNIPQFELLKIEEALAEGLPIDNSFHNHVLNVFRELVEFLRKVLRDEEVLRKLAEDPFISLKEEGGKWYIEIPDVRTYIQATGRTSRLFAGGITKGLSVLIVDNEKVFNGLVRQMRWRFTEFKMTPFEELNLDEILRQIDEDREKVRLVMEGKISAKVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGNRMLTILASGGHMFDLVTNEGYHGVLIEEKDDMLKFIPVYDTIKRCRDCGHQFVDWEEKGICPRCGSTNVRDALENVKAMREIAQEVDEILIATDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILRAIEEAREVNEGRVNAQLVRRIEDRWIGFELSQELQRVFENRNLSAGRVQTPVLGWIIERYKEFTESETYFLGLTLENELSVTIELGKDAKEVEPPEEVLVEDVSLEERELNPAPPYTTDAMLKDASTFLKLSASETMRLAQDLFELGLITYHRTDSTHVSNTGIEVAKEYITQEVGEEYFRPRPWGEEGTHEAIRPTRPIDTGRLMQLIRDGIIQLSKNLTRNHYRLYDMIFKRFMTSQMKSAKVLYEKAIIDAKVGKAEIEGYVEVIEDGWTKLRSPPMRQLPRLEKGVSLKVVEAKKWKAPKVPLYTQGDIIALMKERKIGRPSTYAKIVQTLLQRYYVIETRGRKKLVPTDQGIKVYHYLISKYKELVGEEKTRELEEIMDMIEENKTDYQEVLRGLYSEIREYLK
(930) DNA topoisomerase 1 [Thermococcus onnurineus NA1]
3
MVTLIIAEKPNVARKIAYALAEGRPVRKTIGKVPYYEFTRDGKRIIVAPAVGHLFSLAPKTKTYGYPVFDIEWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNLESTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMVLEKNGQQYTAVYEKERILDENEAKRIVEEAKKGPAFVEKVDVKQQNRHPPVPFDLGTLQREAYSAFGYSPKKTLELAQKLYERGLTSYPRTSSQKLPKNLNFRSILQNLAKLPEYKPFAHELLGKERLKPVEGKKDDPAHPAIYPTGELPKPGELTKDEANLYDLIVRRFLALFMEPAVREIMKVIINSNGHRFILSGARTIKEGWLKVYGKYVKFDEAILPAFKEGEPVKVLQIKREKKKTKPPARYSPAAVIKRMEDLGIGTKATRAQILETLYSRGYIEGKKKIKVTPLGMRVVEALERNVPDIVSVELTRAFEEKMEEIMAGKADKDRVIEESKEQLIKILQQFKEKELDIGKVLMETTGTGVTTSKENAKRAGTVKELSETEEKDVKKTIEKGEKTPLVVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLLQRGRIIPTNKTCCDGAPVVKIREKGREYEICLDMNCKDWKKGKK
Family distribution
Taxonomy tree
Thermococcales