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Taxon : Pyrococcus
Informations
Name
Pyrococcus
Rank
genus
# topoisomerases
14
Lineage and sub-taxa
Lineage
Archaea
>
Euryarchaeota
>
Thermococci
>
Thermococcales
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Thermococcaceae
>
Pyrococcus
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(270) Reverse gyrase [Pyrococcus sp. NA2]
6
MKAIYRGMCPNCGGAITDERLSSKNPCEGCLAEPIVLQDYDKLIEAIRNALKLRDTLKDWEELYRLNKEVSEVEELFERATGFRFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYFATKGKKSYIVVPTTPLVIQTVKKIKAMLERAKLNVNLVYYHGNLKKKEKEEALEKIRNGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLMLGFSEEMINKAWEIIKLKKQLAKLLQNEGKEEEVEKLNREIEKAEREIEAYKKNNNIGILIVASATGTARGDRIKLYRELLGFEVGSGRSVLRNIVDTYLIPEKSIEEHVEELLRKLGKGGLIFVPIDRGIEYAEKLTEYLKKKGFRVELVSAKSKKGIELFENEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEDKRAEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKSAVEFLRAVLKDEEVIKRIAENPFLSLKEIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVVIVDDEKVFNGLLRQMRWRFVEFEMKRFDEVDIDDVLREIDEDRKKVRMVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRKIGDLVAYEVSIGDRMLTILASGGHMFDLVTTEGYHGVLMLKRNGKPYFVPIYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIREARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLVLENGISITIENAKGNVSEVTVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSTHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPVDTGRLIQLIRDGIITLPRNLTRDHFRLYDLIFRRFIASQMKPAKVIYEEAIISTPFGDVEVEGYIDVIYDGWSRIKPLPLKKIPKLEKGQVIKVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLMSKYKPLVNEERTRQLEKIMDMVEEAKADYQDVLNELYDEIKAYVK
(1147) DNA topoisomerase 1 [Pyrococcus sp. NA2]
3
MILVIAEKPNVARKIAGALAEGRPIKRTMFGVPFYELFRDGKKVIVAPAVGHLYGLAPKQDFYGYPIFEIEWVPVYMAEKGKEYAKDYINLLSVLSRRVREFIVACDYDTEGEVIGYTALKYACKVDPKIAKRMKFSTLTKGDLIRAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWIILSTGRVQGPTLKFLVDREREIQSFVPKPYWVIKMVIEKGGKKLVATYEKDKVFDEAEAKRIVEETRKGKAIVEKVEVKRQNRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQSLYEKGYCLHPDSLILTPSGIKKIRELPEKGEVLALDFNLKLSKAKYRLLERDADEPMYRIILSDGTELYLTGDHPVLTYREGRLIFIPAEKLKENDKVVLLNGGYKDTYSLSFLLEEASMDDYIIYEKSFGEVIKTRMTNEMKEIYSYLNGKIPIPVLRFLIEKKIVSEEEIFKVFRGFSYLDSQLPINDRFWHLIGMIIAIGYKLENDNVILLPSKEITNRVIEHVEALGIPFVYDGERLVLKSKSLSRLLKIIGDKVIPPKKDWMISLIKGYQEVNGLRFRDKELAYKLKVMFQLLGVRTRLKRGTTYELVIDSEHEPEVEEGPDAPRVANGDVYILEIKSIDKFHYRGKVYDLVVEDYHNFIANGVIVHNCSYPRTSSQKLPKNLNFRFIIQNIARMPEYRPIAHELLGKEVLKPVEGKKEDPAHPAIYPTGEIPEPGELTRDEWNLYDLIVRRFLALFMEPAVRESMKVIINANGHRYILSGARTVKEGWLRAYGKYIKFDEVILPLFFRGERVRVLQVRRERKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVVETLEKYVPEIVSVELTREFEEKMELIMQGKLTKEEVIEEAKERLTKILQKFKEKELEIGIELAKIVVGEDVKLPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQKGEIIPTNKTCCNGAPVVIIREEDGREIEICLDMNCKWPKSY
(199) DNA topoisomerase 1 [Pyrococcus yayanosii CH1]
3
MILIIAEKPNVARKIASALAEGRPVKKSIYGVPYYELTRDGKRLIVAPAVGHLYGLAPKRDFFGYPIFDIEWVPVYVAEKGKEYAKDYIKALSVLAKRAKEFVVATDYDTEGEVIGYTALKYACGVDPRKAKRMKFSALTKRDLLKAWYNLEPTINFGMAGAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQNFVPKPYWIIKLILEKNGRKLTATYEKDKVWDEEEAKRIVQEARKGYAIVENIDVRRLQRNPPVPFDLGTLQREAYSAFGYSPKKTLDIAQSLYEKGYCLHPDSLIPTPDGIKKIAELPKEGEVLALDFNLKLSRARYRLLERDADELMYKVTLGDRTELYLTADHPVLVCRDDKLIFVPAEELKESDQVVLVIAREGFKGRENPPTLLDFLLENARTMKDYILYDPEFGKDLRRRLKERGLKVEVMAEFNIRESTYYNYLRGKMPVPIAKFLLDKGVISREELRSVFRGFAYSTSLSPISFEFSEEFWYLYGFVVGSSYTVKNGALVISAKEREEDIVRAIREVANSLGVPFRYDAKYKLIIIRSKSLTRLFELLGCSYGNKTRTFRIQGIVVSRPGWIAAFLAGYCDADAHIRVKPTGSRKSLSPQIVLTSKNKEVIYTIKLMWQLLGVRTYLLEKKDKNGVVYELKVYPKDVPRFYEVLRSFLIVKRKDLERVIEIVAGKRAINIEETAIPLTDEDLRRIATGDVYLLKVNGIEKFRYRGKVYDLVVEDYHNFIANGVVVHNCSYPRTSSQKLPKNLNFGAILQGLSKLPEYRPFAHMLLGKEVLKPVEGKKEDPAHPAIYPTGEVPKPGELTKDEQNLYDLIVRRFLALFMEPAVRESVKVTIKAGSHRFILSGARTVKEGWLRVYGKYVKFDEVLLPGFRRGEPVRVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVVETLEKHVPEIVSVELTREFEEKMELIMNGKLTKEAVIEEAKERLLKILEEFKRKELEIGRELAKIVIGEDLVEDKREDIVVVGKCPKCGGDLVVKYNRKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCDGTPIVIIREEDGREYEICLDIRCRKGKGR
(403) Reverse gyrase [Pyrococcus yayanosii CH1]
6
MKAIYRGMCPNCEGRISDERLSMKNPCESCLDEPVGEQVYFDLIKAVRDALKLKGTLKEWEEIYKLNKAVKDVEKFFEKATGFTFWSAQKTWVKRLVRGRSFSIIAPTGMGKSTFGAFMAIYFAQKGKKSYIVVPTTPLVIQTVRKIRTMAERAGVEVNLAYYHGNLKKKEKEDMLAKIRDGNFEILVTSSQFLATRFDELLKDKKFDFIFVDDVDAFLKASKNIDRSLILLGFTEDVIAKAWEIIKLKKQLAKLLQRGNIEDIERLNSQIERLEEEIEAFRQKNNVGVLIVASATGSARGDRIKLYRELLGFEVGSGKSVLRNVVDSYLIPEKPVEDVVAELLQKLGKGGLIFVPIDKGIEYAEKLTEFLKERGFRVELVSARSKKGLELFERGEVDHLVGVATYYGTIVRGLDLPHLIRFALFTGIPKFRFSLDLEQPTIYRVLGLMSEIIEFLPEEDRRTGEKLYSRLRKIIRNVPQFELMKIEEALAEGLPLEGFQNHVLEIFREAVEFLRRVLKNEIVLKKIAEDPFLSLKREGDKWFIEIPDVRTYIQASGRTSRLFAGGITKGLSVLIVDDEKVFNGLVRQMRWRFTEFKMIPFEELDLEEVLKEIDEDREKVKLVMEGKISAKVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGDLVAYEVSIGDRMLTILASGGHMFDLVTNEGYHGVLIQKKEGRPFFIPVYDTIKRCRDCGHQFVDWEEKGACPRCGSKNVHDALENVKAMREIAQEVDEILIGTDPDTEGEKIAWDIRNVLAPYAPVIKRIEFHEVTRPAILKALREARDVNENRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWVIQRYKEFTESETDFLNITLENGLSITLEGAKGKVGEVIVEDVQVEERDVNPLPPYTTDTMLQDASRILGFSAPYAMQLAQDLFEAGLTSYHRTDSIHVSNTGIEIAKEYITQEIGEGYFQPRPWGQEGAHEAIRPTRPIDTGRLIQLIRDGIITLPKNLTRDHFRLYDLIFRRFIASQMKAARVLYEKAIINAGLGKAEVEGYLEVLFDGWSRIKPLPLKQLPKLEPGQRIKVKELKHWRAPKVSLYTQGDLIALMKERRIGRPSTYAKIVQTLLQRGYVVETKGRKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEELMDMVEEARADYQEVLNDLYKEIQTYVR
(432) Reverse gyrase [Pyrococcus abyssi GE5]
6
MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIRS
(176) DNA topoisomerase 1 [Pyrococcus abyssi GE5]
3
MILVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDFFGYPIFDIEWVPVYIAEKNKDYAKDYIKALSVLAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPKPYWVIKLVIEKNGQKLVANYEKDKIWSEEEAKKIVTEVKKSKARVSNIEVKRQKRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTESQKLPKNLNFRLIIQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPGPGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPHKFMLSGARTVKQGWLSVYGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFERKMDLIMQGKLTKEEVIEEAKVKLTKILEEFKKRELEIGLELARIVVGDVKDEIKEEKPIVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIRDKGRDIEICLDIKCKKW
(431) Reverse gyrase [Pyrococcus abyssi GE5]
6
MKAIYRGMCPNCGGAITDERLAEKNPCEGCLSEPIKAEDYEKLVFAVRNALKLRGTLKDWEDLYRLNKEVSEVEDLFKRATGFRFWSAQRTWVKRILRGKSFSIIAPTGMGKSTFGAFISIYFAIKGKRSYIVVPTTPLVVQTVKKIQDMMERAGVNVRLVYYHGNLKKKEKEEALKRIKDGDFDILVTSSQFLATRFDELLRDKRFDLIFVDDVDAFLKASKNIDRSLLLLGFTQEVINRAWEVIKLKKQLAKLLQAQGKEKEVEELNKEIEKIEREIERYRRENNIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPERSIEEEVENLLRKLGKGGLIFVPIDKGIEFAEELTNYLKSKGFKVELVSAKNKRGLELFERGEVDYLVGVATYYGTIVRGLDLPHLIRFAVFAGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPQEKREEGEKLYARLRRLIRNIPQYELMKIEEALAEGIELEGFHNHVLDVFKQAVEFLREVLRDEEVIRRISENPFLSLKEVEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFEIKKFEEINLESVLREIDEDRKKVRLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRRIGELVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLILKDDGKPYYVPVYDTIKRCRDCGHQFVDWEQKGVCPKCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLSPYTPNIKRIEFHEVTRPAILKAIKEARDINEDRVKAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENGISITIENAKGEVKEVEVKDVVIEEREINPLPPYTTDAMLQDASRFLGFSATKTMQLAQDLFELGLCTYHRTDSIHVSNTGIEIAKEYISEEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFRLYDLIFRRFIASQMKPARVLYEKAIISTPFGDVEVEGYIEILYDGWSRVKPLPLKQIPKLEKGQKLKVTEIKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGRKKLVPTEKGIKVYQYLVSKYKDLVSEERTRQLEKIMDEIEEAKADYQEVLRELHEEIKRYIRS
(175) DNA topoisomerase 1 [Pyrococcus abyssi GE5]
3
MILVIAEKPNVARKIAGALSERRPIRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDFFGYPIFDIEWVPVYIAEKNKDYAKDYIKALSVLAKRVKEFIVACDYDTEGEVIGYTALKYACGVDPSRAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPKPYWVIKLVIEKNGQKLVANYEKDKIWSEEEAKKIVTEVKKSKARVSNIEVKRQKRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRTESQKLPKNLNFRLIIQNISRMPQYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPGPGDLSKDEEKLYDMIVRRFLALFMEPAVRESVKVTILAGPHKFMLSGARTVKQGWLSVYGKYIKFDEVTLPEFFIGERVRVLQVRREKKKTKPPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFERKMDLIMQGKLTKEEVIEEAKVKLTKILEEFKKRELEIGLELARIVVGDVKDEIKEEKPIVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIRDKGRDIEICLDIKCKKW
(362) DNA topoisomerase 1 [Pyrococcus horikoshii OT3]
3
MILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKRDVFGYPIFDIEWVPVYIAEKGKEYAREYIKALSVLAKRVREFIVACDYDTEGEVIGYTALKYACGVDPRVAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKLIFEKNGQKFTANYEKDKIWEEEEGKRIVLEVKKSIPRVSNVEIKRQKRTPPHPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFSSYPRTESQKLPRNINFRMIIQNLAKMPQYRPYAHILLGLPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEEKLYDMIVRRFLAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVKKGWLSVYGKYVKFEEVTLPEFFIGERIKVIQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGRLTKEEVIEEAKERLTKILEEFKKRELEIGIELAKIVVGEDEVKPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVVIIREEDGREFEICLDINCKDWKAKSH
(544) Reverse gyrase [Pyrococcus horikoshii OT3]
6
MKAIYRGMCPNCRGAITDERLSNKNPCEGCLSEPILSEDYNELIVAVRNALKLRGTLKDWEELYRLNKEVSEIEELFEKSTGFKFWSAQRTWVKRIIRGKSFSIIAPTGMGKSTFGAFISIYFATKGKKSYIVVPTTPLVIQTVKKIESMLEKANVSVRLVYYHGNLRKKEKEEALEKIRNGDFDILITSSQFLATRFKELLKDKKFDLIFVDDVDAFLKASKNIDRSLIMLGFSEEIIGRAWEVIKLKKQLAKLLQNEKKNEEEIEKLNKEIEKIEDEIEEYKRRNKIGILIVASATGSAKGDRIKLYRELLGFEVGSGRSVLRNIVDTYLLPEKPIEEHVVELLRKLGKGGLIFVPIDKGIEYAEELTDYLKSQGFKVELVSAKNKKGLELFEKGEIDYLVGVATYYGTLVRGLDLPHLIRFAIFTGVPKFRFSMDLEQPTIYRVLGLMSEILEFLPEEKKSEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFHNHVLEVFKQSVEFLREVLKDEEVIKKIAENPFLSLKEIEGKLYIEIPDVRTYIQASGRTSRLFAGGITKGLSVIIVDDQKVFNGLIRQMRWRFVEFDIKKFEEVNLKEVLKEIDRDREKVKLVIEGKISEQVKDLVKSALMIVESPNKARTIASFFGQPSKRKIGDLTAYEVSIGDKMLTILASGGHMFDLVTNEGYHGVLILKNNGKPYFVPVYDTIKRCRDCGHQFVDWEQKGVCPRCGSRNVHDALENVKAMRELALEVDEILIGTDPDTEGEKIAWDIRNVLAPYAPNIKRIEFHEVTRPAILRAIREARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENRNLSAGRVQTPVLGWIVQRYKEFTESETDFLGIILENGINVTIENAKGEVREVEVKDVIIEEKDVNPLPPYTTDTMLQDASRFLGFSATKTMQLAQDLFEAGLCVTPDTLVSLSDGRIIEIREAVENSEESLLGINGLKPKEAKALKFWEIDWDGPIKVIKLKNGHEIKATPDHGLLVMRDGKIGWVSAKNIREGDYVAFIYNLGHRGGKKYTLPQLLKELGISEYENSSSQELNNREQEMDSKQISIELDERFWYIFGVILGKGTLKGDKVVIFQKDVKPVIEEALPFVRIFESADHIGFSHLILAEVFRRLGVGEGKLHSLVFGLREEYINAMIAGYFDASGTFLRRAVLTSKRGDILRMLSVYLYQIGIVNNLRRDEHAGVWELIISDLEKFREKIYPYLRIKKSQFDKVYSISKNEGDFLPVASIFRKLKFRDGFKNRILDEEIPRDEVAKVLEYAEDSPEKEFLNSLVEARVTWVRVEKIEERHYTGKLYDFTTTTENFISNGIVSHNCTYHRTDSIHVSNTGIEVAKEYITQEIGEEYFTPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITIPKNLTRDHFRLYDLIFRRFMASQMKPAKILYEKAIISTPFKDVEVEGYIDVLYDGWSKIKSLPLRQIPKLEKGQRLRVKEVKQWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKGKKKLVPTEKGIKVYQYLITKYKDLVSEERTRQLEKIMDMVEEAKADYQDVLNELYEEIKRYVR
(1203) DNA topoisomerase 1 [Pyrococcus furiosus DSM 3638]
3
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTANYEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELWYLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLELAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
(1220) Reverse gyrase [Pyrococcus furiosus DSM 3638]
6
MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS
(1204) DNA topoisomerase 1 [Pyrococcus furiosus DSM 3638]
3
MILVIAEKPNVARKIAMALAEVKPIKKTLFGVPYYELIRDGKRLIVASAVGHLYGLAPKNDFFGYPIFDVEWVPVYIAEKGKEYAKDYIKLLSVLSKRVREFIVACDYDTEGEVIGYTALKYACGVDPGVAKRMKFSALTKRDLIKAWYNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVDREREIQSFVPQPYWVIKLIFEKNGKKYTANYEKDKIWDENEAKRIVLEVKKAPARVTNIEVKQQNRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFCLHPDTLILTSQGVRKIKELSREGEVFALDFNLKLSKAKYRLLERDADEQMYKVTLLDGTELYLTADHPVLVYREGNLAFVPADKLRETDHVVLVLNKSARDNYGFLDLLLEITDSQEDYAILENGETLSLHSLKMLVERGEIKDIAVVGFSHNNFGKVMLRDELWYLIGYLAGKGGEIKGNGVVISSRTKEIVGLTKSLNIDLIETEEGIVLSNKSFVRLLHLIHYTPRVPEVYGIINNTEWLKAFLAGYYDATLLEGLTLEALYKIKVYLQLLGIRAKIEDNKLKVHLEDLQRFRELLGKFSRRKLYVETSQVPVFTDFDERSYDFPRILGGDIYIIGIKSIEKFHYKGKVYDLVVENYHNFIANGIAVHNCSYPRTESQKLPKNLNYKFIIQNLARIPEYRPYAHLLLGMPELKPVEGKKEDPAHPAIYPTGEIPRPGDLTKDEALLYDMIVRRFLAVFMEPAVRETVKVTISAGKHKFFISGGRTVKEGWLRVYGKYVKFDEVTLPTFFIGERIKVLQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGKLTKEEVIEEAKIRLTKILEEFKKKELEIGLELAKIVVGEEKPPLIVGKCPKCGGDLIVKYNEKTGKRFVGCSNWPKCNVTYPILQRGEIIPTNKTCCNGAPVVIIREKDGREWEICLDMNCKEYNTIKKKR
(1219) Reverse gyrase [Pyrococcus furiosus DSM 3638]
6
MKAIYRDMCPNCRGAITDERLAAKNPCDACLDEPISMDDYFQLVTAIRKALKLKGVLKEWEEIYALNKEVKEIEELFKKATGFTFWSAQRSWVKRIIKGKSFSIIAPTGMGKSTFGAFMSIYFALKGKKSYIVVPTTPLVVQTVKKIKAMMEKAEVKVNLVYYHGNLKKKEKDEALEKIKSGNFDILVTSSQFLATRFDELLKDKRIDFMFVDDVDAFLKASKNIDRSLMMLGFNEEIIKKAWEIIKLKKQLAKLLQNESGNEEVEKLNREIERLEREIERYKKENKIGILIVASATGSARGDRIKLYRELLGFEVGSGRSVLRNIVDTYIIPEKSMEEHVEELLKTLGRGGLIFVPIDKGIEYAEQLTNYLKSKGFKVELVSARDKKGLELFEKEEVDYLVGVATYYGTIVRGLDLPHLVRFAIFTGVPKFRFSLDLEQPTIYRVLGLMSEILEFLPEEKRTEGEKLYARLRRLIRNIPQYELMKIEEALAEGLELEGFYNHVLEVFKQAVEFLREALKDEEVLKKIAENPFLSLKQIEGKWYIEIPDVRTYIQASGRTSRLFAGGITKGLSVILVDDQKVFNGLIRQMRWRFVEFEIKPLGEINIEEVLKEIDRDREKVRLVLEGKISEQVKDLVKSALMIVESPNKARTIANFFGQPSKRRIGDLVAYEVSIGDKMLTILASGGHMFDLVTTEGYHGVLLLEKGGKRYFVPVYDTIKRCRDCGHQFVDWEEKGVCPRCGSRNVYDALENVKAMRDLAQEVDEILIGTDPDTEGEKIAWDIRNVLSPYAPVIKRIEFHEVTRPAILRAINEARDINEDRVNAQLVRRIEDRWIGFELSQKLWEVFENYNLSAGRVQTPVLGWIVQRYKEFTESETDFLGLTLENDITIILEGVSGDVQEVYVKEVTIEEREINPLPPYTTDAMLQDASRFLGFSATHTMQLAQDLFELGLTTYHRTDSIHVSNTGIEIAKEYITQEIGEEYFAPRKWGEEGAHEAIRPTRPIDTGRLIQLIRDGIITLPRNLTKDHFKLYDLIFRRFMASQMKPAKVLYERAVIGTPYGEVEIEGYIDVIYDGWSRIKPLPLKKLPRLEKDQILKVTEIRKWRAPKVSLYTQGDVIALMKERGIGRPSTYAKIVQTLLQRGYVIETKSKKKLVPTEKGIKVYHYLVSKYKDLVSEERTRQLEKLMDMVEEAKANYQEVLNELYEEILRYVKS
Family distribution
Taxonomy tree
Pyrococcus