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Taxon : Thermoproteaceae
Informations
Name
Thermoproteaceae
Rank
family
# topoisomerases
22
Lineage and sub-taxa
Lineage
Archaea
>
Crenarchaeota
>
Thermoprotei
>
Thermoproteales
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Thermoproteaceae
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(1877) Reverse gyrase [Vulcanisaeta moutnovskia 768-28]
6
MEKQPIVIYRKACPNCGGDITSDRLGAGLPCYKCLPEVAKKVANTIEVLNTLEKLGTINRLKSLSNLINEYNEFMNMFKKVVGTNMWGAQRLWTRRLIKGKSFAIVAPTGSGKTTFGMMASLYIALRKRSKVLIVVPTSTLAYDVHRRLSEYSGKMNSNIRIIMASSILYKQELIDAMNAIENGDFDILIITNAFLPRHMDLLRKYRFSLIFVDDVDSVLKASSKNIDRLLLLLGINEEALHKALTVVDLMKKLRKAIRFRASDEEINKLKEDIKKLSTELSNYVKSNNIGILIASGALTRIRRTARLFLFREFLGFETGGRAEGLRNVVDAYTRPKDSLVSAAVEIVKRLGGGGIIYVPPDLREIIDELSEKLNNNGIKAAAYLKPSKSLLNDFVDGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMKFRIKLEEFTPMRYLMFLFNIRNIVPQYLRNDVDRVIARLRNLTALNQEQVNNLLMAIEENRELSGFDKYAADVIKDAVDLVNKLLSDPGIRRAIEQSNEVGLEYRGNDLYVIIPDLTTYIQGSGRTSRLYVGGVSLGLSVLIVDNEKVFNGLVRNLRYRLEDVKVQDINEINIDELMKKIRNERELIRNIMLGRIPNQFLEKDPLRTAFVIVESPTKARTIANFFGVPTRRETGPLVIYEATLGNLYLLITATKGHMWDLIPAAPADVKSFSSFLRSEKLLDYYGILRAGNNFVPIYGTIKRCPVGGETYTEDINVCKIHGAELIDAMDIVNAVRDIATEVDQVMIGTDPDAEGEKIAWDVYMMLRPYVGNIARIEFHEVTKKAIIDAIMNPRTISLSMVGAQLVRRIEDRWIGFGLSQIVQEKFGRRTLSAGRVQTPVLGWIIERYDESRKDKIYTVTMTLSNGIKIRLGIPPDKEELVKTLKALHRNKAVDAVIKVAVTKVGETEEELNPPPPYTTDALLRDSANILGLSVEQTMAIAQELFESGLITYHRTDSTRVSSVGIGIAKEYISEKVSSDYFVGRTWGGKEIGAHECIRPTRPIDSDDLRNLLNTGLLQLAIKVTANHLRVYDLIFKRFIASQMKSAKVMKEKLRISVYFNGVDTHDEEIERISKILEPGFTRFWGYLEGKEYQELTPGEYNVTSIDYIKKVSRTLPLREGDIIAMMKERGIGRPSTYAKIVDVILKRRYALVVGRRTRYVVPTNLGRQVYKFLTEDNKEFSDLVSEERTRMVEKHMDDVEVGERDYMDVLNELFNEAISKGILKENVIS
(322) DNA topoisomerase [Vulcanisaeta moutnovskia 768-28]
3
MIIDSLVVAEKDSVARAIAKYLAQGSISIRRIYGIKAYWFTRDNRQWVSIGLKGHIMNVDFSEELNKWHSVEPSKLFDVEPILVIRGDDLNYVRALTHLGASANTVYLALDADPEGEAIAYEAMFVIRNVNPGAVFKRVLFSAVTRNAIIEAFNSPTNLNPGLAKRVFTRMVLDLTLGAVFTRALTLSVEKIDRKALSRGSFLSYGPCQTPVLNLVVQRALERENFKPEKYYTLHIIVDADGKRIMLDHDGVFKDRQEAEKILNLVRSMAKAKVIIASYKEDFLGPPVPLDTIELERRASRFLNIRPKAALDIAEELYRHGYISYPRTETTIYPPTLSLKQVLLELTHGEHGDYAKTLLGMTIKPTRGNSNDGAHPPIYPTRGVSRQELLRYFKNERYWKIYDLVVRHFMATLSPPARIERQRIVVEVVDHRFSTDGLRMIDKGYLVIYPFESPSEKVLPRVKLGDELSIIKAWVEERETEPPPYLSESELLRLMRKYGIGTDATMQDHIHTNIIRGYFRVRNKQCIPTPLGKAVINVFSKTGGELIDPWFRSRMEKALMEITSGSLRPTDVLFTFKSEARKIYEKFMNRQNEVAMELIKALKESLSKTNRNSNRKVS
(863) Reverse gyrase [Pyrobaculum aerophilum str. IM2]
6
MEVPLVAYLHSCPNCGGPITSDRLASGLPCRECLPDGAKAGSIKQVITALRKRKALQGLAWVEAYLRGYEEFAEFFKRIVGFEMWGAQRLWARRFVRGKSFAIVAPTGSGKTTFILIATLYSAKQGKRALLIFPTSALAHQAYKKLLTFAERGGVSLKALAYHSLLTEREKKEALEALERGDFDVLVTTSAFLPKRFELLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDAVLNTALEVINLTKQLRKAEVAGDLKEVERLDQEMAKLRAKLREEVQRLKLGVFVASGALAKARRTVRLLLFREILGFDVGGRAEGLRNVVDLYVEASDNVIEQTLALVKRLGPGGIIYVQDRELGEAIVERAREAGLAVEHFFRPRRGVLESFERGELAALVGLASSRSALVRGIDLPHVIRYVIFVGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLAGDARYKADRLIGQLKRLAPYALSVQEALKKASEGAELSSFDRHAVDVVKSAVEFVNSLLQNEEIRKAIETSSEVKLAYIDGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDPKVFHALKRELSLRFDEAEFKHLGEADLDKILADVDRDRKTIRDIMEGRLVPAARGVDLMRTILMVVESPTKARTIANFFGRPSLIISEGIPIYEVSTGDAVLMVTASLGHIYELPTSLNKIDQRQREVLAKWFGDFKHGNYDGENYAVIVKEYGFVPVYNKIWRCRGAVYVDDIDIPPGCKPLDVLEAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVQDIRRVEFHEVTRRAILNALANPRGVNFSLVKAQIVRRVEDRWIGFGLSKILQANFKNPNLSAGRVQTPVLGWIVNTYEESLKNRVYNVELQLNDVDIRLQVPRDVLDVLRKKKRVAIKLVARERRQVNPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGIAIAREYIVRKFGEGVFKPRSWGEAEEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQLTKSHYQLYDIIFRRFMASQMEPSVVEVAKYNVEIDGHVIQLERTVGVAYMGFQTLYQLTPVEPELPTGTLDVVIKRYRVVRRVLSQADVLALMRQRGIGRPSTYAHILQVLAKRYYVYVTGRTKLMIPTKRGREIFRFLKEAFGKLVSEDRTRLIEQYMDAIEVGKARYEEVIAELYDEFRKEVLPHLAS
(207) DNA topoisomerase (TopA) [Pyrobaculum aerophilum str. IM2]
3
MKLIVAEKRSVAQSIAKFLGRSYKSQKLYGVSVYRFNYGGGEAVAIGLSGHIMDFDFAARQNVWTWLPPEELFNATPILVLRGETLKYVKALKSLATKADEVYLALDADVEGEAIAYETALVVKMVNPRARLYRVRFNAVTYKEIVSAFQKPTYIDLKKVEKVFTRMQVDLTLGAVFTRFLTLTVRNSLNKGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKAVVEIGSSKVEMSADAKFKTKGEAEAIAATIKRGVVKIAVYKPHYVEPPEPLETVELERRASRWLGINSKKTLDIAEELYRAGYISYPRTETTIYPPTLDLKEVLEELTAGEHGPYALELLRKGFKPTRGDSDDGAHPPIYPTKGATRAEIFKVFGKAGGHAWAVYDLVVRHFLATLSPPALVEKQKIVVSFGKIELSAEGQRTIDEGYWRIYPWERQPEKPLPRVAPGEPARAVEIRVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIYTNIKRGYVKLVKGKCIPTALGISLATSLFQYAPELIEPTVRAKIEKSLNSIVKDGVSPAKLIAEIKLEFSKYYQNLKAKREEIKKALETALYSIQQQSRG
(898) DNA topoisomerase [Pyrobaculum calidifontis JCM 11548]
3
MKLIVAEKRSVAKAIAQFLGGSYRAQRVYGVPAYFFNYGGEAVSLGLMGHIMDFDFAARENVWTWIPPEQLFHATPLLVIRDEAAQYVKALQSLARRADEVYLALDADVEGEAIAYEAAIAVRAVNRRARLYRVKFNAVTPKDIRAAFQKPDTLNLKLVEKVFTRMQIDLTLGAVFTRALTLSVRNSLEKGQFLSYGPCQTPVLGIVVNRELERINFKPEKYYVIKAVVDIGGHRVEMGSEVRYKTRAEAEAAASLIKRGVVKAAVYRPHKVEPPEPLETVELERRASRWLGINSKKTLDVAEELYRAGYISYPRTETTIYPPSLDLREVLQELAKGEHGEYARGLLKAGFRPTRGDSDDGAHPPIYPTKGATKDELYRRFGKAAAYAWPIYDFVVRHFLATLSPPAVVEKQKIVVSFGKIELEAEGQRTLDEGYWRIYPWERQAEKPLPVVKPGEAAYAVKVSVVERETQPPPPMTESELLALMKKYGIGTDATMQDHIHTNVKRGYMRLQKGKCTPTPLGMALATALFQYVPELIEPTVRAKIERALNSIVRDGVPPAKLAAEVKAEFAKYFEKLQQHRREIKEALEKALNSSP
(632) Reverse gyrase [Pyrobaculum calidifontis JCM 11548]
6
MDIPLVVYLHSCPNCGGPVTSDRLAGGLPCRECLPEVVKAGGIADVVRALRRRRALKGLAWVDEYLRRYEEFSSLFKAAVGFEMWGAQRLWARRFVRGRSFAIVAPTGSGKTTFILVATLYAAREGKRALLIFPTSALARQVHQRLLSYAEKAGVSVRAVAYHSLLTEKEKKEALGAVEGGDFDVLIVTSAFLPRYFDLLKRFKFDFVAADDVDSILRATSKNIDRILRLLGVSDEVLKLALDVINAVKELRKAEIAGDLKEVERLDAEVTALRAKLQEEARRLKLGIFVASGALARARRTTRLLLFREILGFDVGGRAEGLRNVVDVYVEQGKDVVGQVVELLKRLGPGGIVYVQDRELGLAIVERAVGESLAVEHFLRPRRGVLERFERGELAALVGLASARSALVRGIDLPHVIRYVVFVGVPKYKFRVRLEEFSIPAYLTFFYNVRAVLSGELRYKVDRAIGQLKRLAPYALSVQEALKKAAEGQELSSFEKHAVDVAKGAVELANSILSDEELRRAIDSSTEVRLAYIGGELYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVVDDWKVFTALQRELKLRFDEAEFKRLDEVDLSAVLAEVDRDRRTIREIMEGKAVVTGGRELMRTLLMVVESPTKARTIANFFGRPSMLLVDGVPVYEVSTGDAVLMVTASLGHIYELPTSLDRISKEEREVLRRWFGDFRRGDYDGGEYAVLATEGGFVPVYNKIWRCRGAVYVDDVDVPPDCRPLDVLAAIRNLAVEVDAVLIGTDPDSEGEKIAFDLYLGLRPYVADIRRVEFHEVTRRAIISALANPRGIDYSRVKAQIIRRIEDRWIGFGLSKILQREFGSPNLSAGRVQTPVLGWVVTTYEESLRQRMYNVELQLDDVDLRLQLPQEALKALRERRRVAIRKAGAETRVVNPPPPYTTDELLRDAVNRLGLSADYAMRIAQDLFESGLITYHRTDSTRVSAAGIAVAREYITKRFGEGAFRPRTWGEEAEGAHEAIRPTRPIDVEELRGLVNAGVLQLAIRLTRSHYQLYDLVFRRFMASQMEPSEVEVERYEVEIDGYVAQVERVVDIKRQGFQVMYQVTAVEPGLPTGTIEVTVKRYRVIRRILSEADVLALMRQRGIGRPSTYARILQVLAKRYYVYVAGRRRLMVPTKRGIEVYHYLEQKFGKLVSEDRTRLIEQHMDAVEQGKAKFEEVLGELFDEFKTEVLPNLSGASPKS
(471) Reverse gyrase [Vulcanisaeta distributa DSM 14429]
6
MEKQPLVIYRRACPNCGGDITSDRLASGLPCHRCLPDVPKKVASTIEVLNMLEKLGTINRLRSLANLVNEYNEFADMFRKIIGTNMWGAQRLWARRIIKGKSFAIVAPTGSGKTTFGMIASLYVALKRRGRVLIVVPTSTLAYDVHRRLSDYVNKMGVNVRIVMASSILSKQELTEAMKTIEDGNFDILIVTNAFLPRHMDLLSRYRFSLIFVDDVDSVLKASSKNIDRLLLLLGINEEALRKALTVVDLMKKLRKAIRFRASEEEINKIREDIKRLNAELTNYIKSNNIGILIASGALTRMRRTARLFLFREFLGFETGGRAEGLRNVVDVYVRPRDSLISTAVDIVKRLGSGGIIYVPPDLRDIVDELLEALNKNGVKAASYLKPSKSLLNDFVEGKIDVLIGLATSRSSLVRGIDLPQRIAYVVFVGVPRMRFRLRLEEFTPIRYLMFLFTIRNVVPQYLRNDIDRVVARLRNLTALNQEQINNLLKAIEENKELSGFDKYAADVIKEAVDLVNKLLSDPNIRKAIEQSNEVGLEYRGGELYVIIPDVTTYIQGSGRTSRLYVGGVSQGLSVLIVDNEKVFNGLIRNLRYRLEDVKIQDINEVNIDDLMKRIRSERDLIRNIMLGKIPNQFLEKDPLRTAFVIVESPTKARTIASFFGVPTRRNVGPLIIYEATLGNLYLLITATKGHMWDLIPAGPADVKELAPALRAGKIIDYYGILKTGNNFVPIYGTIKRCPVGGETYTEDVDVCKIHGVKLVDAMDIVNAIRDIATEVDQVMIGTDPDAEGEKIAWDVYMMLRPYVSNIVRIEFHEVTKKAIIDAITNPRAISLSMVGAQLVRRIEDRWIGFGLSQIVQEKFGRRTLSAGRVQTPVLGWIIERYDESRRDKVYSVTMTLSNGVKVRLNIPPDKEELIKALKAMHRNKSTDVEVKVRVTKVGEEEEELNPAPPYTTDALLRDSANILGLSVEQTMAIAQELFESGLITYHRTDSTRVSTVGIGIAKEYISERVGADYFVGRAWGGKEIGAHECIRPTRPIDSDDLRNLINTGLLQLAIRVTANHLKVYDLIFRRFMASQMRSARVLKEKLRISIYLNGANVHEEEVERVSKILEPGFTKVWGYIEGREYQELMPGEYGITSIDYIKKVSRTPPLREGDIIAMMKERGIGRPSTYAKIVDVILKRRYALVVGRRTRYVVPTNLGRQVYKFLTEENKEFSDLVSEERTRIVERHMDDVEVGERDYMDVLNELFNEAVSKGILKENVIT
(1660) DNA topoisomerase [Vulcanisaeta distributa DSM 14429]
3
MIIDSLVVAEKDSVAKAIAKYLAQGSISVKKVYGVKSYWFTRGGRQWVSIGLKGHMMDVDFPEELNKWHSVEPSKLFDAEPILVIREDTISYVRALSRLGASASVVYLALDADSEGEAIAYEAMLVIRNANPRAVFKRVLFSAVTKSDIIEAFNSPTSLNPGLAKRVFTRMILDLTLGAVFTRALTLSVEKTDKNALARGSFLSYGPCQTPVLNLVVQRALERENFKPEKYYTLHIIVNVNGVRVTLNHDGTFKDKQEAERVLSLVRGKARAMVIIANYKEDFIEPPVPLDTIELERRASRFLNIRPKAALDIAEELYRHGYISYPRTETTIYPPTLSLRQILLELTHGEHGDYAKTLLGMSIKPTHGDSNDGAHPPIYPTRGVTRQEILRYFKNEKYWKIYDLVVRHFLATLSPPARVERQKIVVEISGHRFSVDGLKIIDKGYLTIYPFESPSEKVLPRVRVSDELSIVKAWIEERETEPPPYLSESELLRLMKKYGIGTDATMQDHIHTNVIRGYFKIRNKQCIPTPLGKAVISVLSKTGNELIDPLFRSRMEKALMEITSGSLKPDDVLFTFKNEARKIYEKFINRQREVAMELIKALKDSLSKGNKGAGGKAS
(1325) Reverse gyrase [Thermoproteus uzoniensis 768-20]
6
MDFRVLPALYLHSCPNCGGAVESYRLAEGLPCSECLPEEVAGSDIRRVIENLRRRNALRGLAPLADVLRRYEEIANLFEKVVGFRMWGAQRLWARRLAAGKSFAVVAPTGSGKTTFLLISALYMTSRGKALLVFPTSALAYQAYKKLLDYSSRAGLAPRIVTYNTMLKPQEREEALKRIEAGDFDILVITSAFLPKYFELLARHKFAFVATDDVDSVLRATSKNIERLLKLLGATDEVLGKAFELIELGKKRGKAVLAGDEKEAERIEREIEKAREELRRIKAELRLGVFVASGALAKARRTARLLLFREILGFDVGGRAEGLRNVYDLYVKMAEDPKTQVAELVKRLGGGGIIYVLDKDFGKDLVQHLQASGIKAEHFFRPRRKVLEAFEQGQLSVLVGLASPRSALVRGIDLPHVIRYVVFVGIPKYKFRVKLDEFSVPAFLSFLYNVRAILPQDLRFRADRLIAQLRRIAPYSARLDKILKEGASNSFEEYVLGVAKSAVEFVASLLSRDDIRKAIEASTEIKLTYIGEQLYVLLPDVTTYIQGSGRTSRLYAGGLSRGLSVVLVDDEKVLNALIREMELRFDDVRFEELSKADLDGILKSVDEDRENIRRILSGMLKPEELASRDLMKSILLVVESPTKARTIASFFGRPNMLIIGGMPAYEVSTGDSMLTVIATMGHIYELPTNLQRVAEDERRKIWRLVKPVAAGPYSPMDYSVVKTEAGYVPIYNRIYKCPGSSYVDDLDVPEGCKPLDMISTLRELASEVDAVYLGTDPDSEGEKIAYDVYLILRPYVGLIKRIEFHEVTRRAIMNALASPRDVNLSMVAAQIVRRIEDRWLGFGLSRKVQEAHGLAFLSAGRVQTPVLGWIVERYENSKAERKFDVVLKIGDGQIRLALPEDVYKALKENRKARISLLEEKTETIQPPPPYTTDEYMRDAVNKLGISAEEAMSIAQDLFESGFITYHRTDSTRISTTGIGVAREYVARRHGADAFRPRTWSAGEEGAHEAIRPTRPIDAEELRGLVAAGVIQPTIRLTRNHYAAYDLIFRRFMASQMREAEVVVARYALLLDGFNAEVRRVVEVKNEGFLAEYRSVELEPRLPTGEVDVEIAYAKRLVELLSQADVLRMMRERGIGRPSTYAKILEVLSRRGYVVVRGRRKFMIPTKRGIEIYRYLRENYGKLVSEERTRLIEKYMDDVENGRKNYVAVLDELFTEFLQEVLTRQ
(1621) DNA topoisomerase [Thermoproteus uzoniensis 768-20]
3
MLIVAEKRSVAQAIAKYLGGTYSSFKVSGVSAYRFKYDGASAVSLGLSGHILDFDFPQEMNRWGAVDPARLFDEAVVLTPRPETLKYLYALRSLARGQDVVYLALDADSEGEAIAYEVVLQVRVVNPAARFKRVRFNAVTKAEITRAFARPVDLDLKVVEKVFARMASDLTIGAAFTRLLTLSVRREDSSALPFGKFLSYGPCQTPVLGLVVSRELERLNFKPEEYFVVRAVVGTGGGEVEMRSKPFKRREEAEAALAAARKAEGRIAEARYEKAEVRPPVPLETVELERRASRWLNIRAKAALDIAEELYRLGYISYPRTETTIYPPTLDLRAILEELRNTPFGQYAEDLLRRPFTPTRGRSDDGAHPPIHPTRGAGRGEIEARLGQRGWKIYELVVRHFLATLSPPAVVERQRIAAAFGPLVLEAEGRKVISKGYWTVYPYEEEEEEPLPYVKRGDPAELLSAKIERRLTEPPPRMTESELLKLMRKYGIGTDATMQDHIHTNVLRGYMRIAGGKCIPTPLGMSLATALMKHARPIIDPEVRSKMEAALQEIAAGRMDPSKVVAAIREEFKKYYKFLEDKKAEIAGELVKALKEGPDRKQ
(1125) Reverse gyrase [Thermoproteus tenax Kra 1]
6
MDFKTIRAIYLHSCPNCGGAVDSSRLAQGLPCSECLPRALKLENLKSVIQALKSEGSLKELATLDEVLRRYEELNVLFEKVVGFRMWGAQRLWAKRLAAGKSFAVVAPTGSGKTTFLLVSSLYMARGGKVLLVFPTSALAYQAYKKLLDYSARANYSGRIISYNTMLREQEREEALKRIEEGDFDILIITSAFLPKYFDVLAKYKFIFIATDDVDSVLRATSKNIERLLRLLGATDEALNLALDIIELNKKRARQMLGGDEKGLEESDVEIKRKREELRRLKARLKLGVFIASGALAKARRTTRLLLFRELLGFDVGGRAEGLRNVYDVYAKLSEDPRAQVAALVKRLGSGGIIYVQDKDLGRELVEYLKGEGIKAEHFFRPRRKVLEAFERGELDALVGLASARSALVRGIDMPHVIRYVIFVGIPKFKFRVKLDEFSAPAYLAFLYNVRGVLPQELKFKADRLIAQLRRIAPYTAGLEKVLTEGPKNSFEEYLLNVVKSAVEFVGLILSRDDVKRAIETSTEVKLTYIDGQLYVLLPDVTTYIQGSGRTSRLYAGGLSRGLSVILVDDEKVLHALRRELELRFDEVKFYDLAETDLDKILREVDSDRETIRRILSGSFKPEELSARDIMKSVLLVVESPTKARTIASFFGRPNMLIVGGVPAYEVSTGDMMLTVIATMGHIYELPTSLAKIEPSEKERVLRAVGRTLSEIYSPEDYAVFKTEDGYIPVYNRIYKCPGASYVDDTEVPENCQPLDIISTLRNLASEVDLVLLGTDPDSEGEKIAYDVYLALRPYVGSIKRIEFHEVTRRAIVNALSSPRDVNLPMVAAQMVRRVEDRWIGFGLSRRVQEAHGLAFLSAGRVQSPVLGWIVERYQSSRAERKFDVTIELEDGSIRLTLPEDSYKALKSEGRVRIKRLEGREVVLQPPPPYTTDEYMRDAVNKLGITAEQAMAIAQDLFESGFITYHRTDSTRVSATGIGIAREYISKRFGADLFKARPWATGEEGAHEAIRPTRPIDAEELRGLVAAGVIQPTIRLTRNHYAAYELIFRRFMSSQMREALVRVEKYEVEAGGYKAEVERVVEIKEEGFLRMYRTVEEARPLREGESPIKITYAKRHVELLSQADVLRLMKERGIGRPSTYAKILEVLSKRGYVVVRGRRKFMIPTKRGIEVYQYLKSNFGKLVSEERTRLIERFMDDVENGRRDYRAVLDELFEEFIEEVLKR
(1842) Topoisomerase (DNA) III alpha [Thermoproteus tenax Kra 1]
3
MLIVAEKRSVAQAIAKYLATSYSYFKISGVMAYRFKYKDRQAVSLGLSGHILDFDFPQELNKWNALEPVELFDKITVLVPRDETIKYLYALRALARDEDEVYLALDADSEGEAIAYEVVLQVRAVNPRARFKRVRFNAVTKKDIVQAFERPVELDLKVVEKVFARMVSDLTIGAAFTRLLTLAVREVDNKALPFGKFLSYGPCQTPVLGLVVSRELERLNFKPEEYYVVKGIVETEAGSFEARSRPFKAREEAEAAVRAARVSLGKVIEARFEETRVKPPAPLDTVELERRASKWLNIRAKAALDTAEELYRRGYISYPRTETTIYPPTLDLRAVLEELTNTQFGQYAERLLRGPISPTRGNSDDRAHPPIYPTRGATKAEVERALGTRAWKLYEFVVRHFLATLSPPAIVERQRIAVAFGPLVLEAEGRRIIERGYWEIYPYEEEEDRRLPRVQAGVWARMVSAKIEKKKTEPPPRMSESELLRLMKKYGIGTDATMQDHIHTNVIRGYMRIVGGRCVPTKLGMTLASSLMNHARPIIDPTVRSKMEAALQDIAVGRADVKKVLETIRGEFKTFYKGLYEKRQEIARELVKVLREETRNGPRSDV
(372) Reverse gyrase [Pyrobaculum islandicum DSM 4184]
6
MDVPHVVYLHSCPNCGGPITSDRLAAGLPCYECLPKEPQAKAIGEVVEALRRRKALKELARVAEYLREYNKFSAFFKEIIGYEMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFILVATLYMALRGKKTLLIFPTSALAHQAYKKLMSFAEKVGASVKTLAYHSLLTEKEKDEVLAAIERGEFDVLIITSAFLPRRFDLLSRYKFEFIAADDVDSILRATSKNIDRILKLLGVSDEVLKTALDIISLTKQIRKAEVVGDLKEVERLEQELSSARAKLQEEVRKLKLGIFIASGALAKARRTTRLLLFRELLGFDVGGRAEGLRNVTDVYIDMSQDVVMQTIEILKRLGPGGIVYVQDRELGIAIAEKAKERGLSVEHFFKPRRGILESFEKGEIYALVGLASPRSPLVRGIDLPHVIRYVVFVGVPKYRFRVRLEEFSIPAYLTFLYNVRTVLTGELRYKADRLIGQLKRLAPYAISVQEALRKASEGAELTGFDRHVVDVVKSAVDFVNNLLMRDDLRQAIESSTEVKLTRIDDEFYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVIVDDKKVFHALKRELKLRFDEAEFKHIDEVDLNAVLAEIDKDRKAIRDILEGRVTPATKGVELLKTVLMIVESPTKARTIANFFGRPSLIVTDGVPIYEVSTGDAVLMITASLGHIYELPTSLKRIDSRQREILAKWFGEFKYDSYNGEEYAVIVKEGSFIPVYNKIWRCRNAVYIDDTDVPPDCKPLDVLSAIRNIAIEVDTVLIGTDPDSEGEKIAFDLYLGLRPYVSDIKRVEFHEVTRRAILNALANPRDINYSLVKAQIVRRVEDRWLGFGLSKILQTKFGNPNLSAGRVQSPVLGWIVKTYEESLKNRVYNVDLQLDAAYCVEPSSCVLRLQIPGDILQTLKKKKRVAIKKESEEERVVNPLPPYTTDELLRDAVNRLGLSADYAMKVAQDLFESGLITYHRTDSTRVSAAGIAIAKEYITKRFGEGVFKPRSWGEATEGAHEAIRPTRPLDVEELRGLVNAGVIQLAIQLRREHYQLYDWIFRRFMASQMEPSVVKAIKYVIEIDGHSLELERVVETIRPGFQQLYPLTPVEPELPTGTIEVAIKRYRVVRKVLSQADILALMRQRGIGRPSTYARILQVLAKRYYVYVVGRRKLMVPTKRGIEVYHFLENNFSNLVSEERTRLIEQYMDAIEVGNAEYEGVLKELFDEFTREILSRAPLT
(1250) DNA topoisomerase [Pyrobaculum islandicum DSM 4184]
3
MILIVAEKRSVAQAIARYLGGTYKVEKIYGVSAYRFLYGNREAVALGLSGHIMDYDFTARQNVWSWLPPEELFKTSPILVLREEAIKYVRALRSLARKAEEVYLALDADSEGEAISYEVALVVRLVNKNVKIYRVRFNAVTYKDIKIAFQNPTKLDLKQVEKVFSRMQIDLTLGAVFTRFLTLTVRDLLEKGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKAVVEIRGYKIEMSADVRFKTRKEAEAVATTIKRGVVKAAIYRPHYIQPPEPLETVELERRASRWLGINSKKTLDIAEELYRAGYISYPRTETTIYPPTLNLREILQELIRGEHSRYVEELLLRGFRPTRGDSDDGAHPPIYPTKGATKSEIYKTFGKIGDNAWAIYDFVVRHFLATLSPPAQVEKQKIVVDFGKIQLEVEGQRTIDEGYWRIYPWERQSDRPLPRVYVGDEVHAIKVEVVERETEPPPPMSESELLALMKKYGIGTDATMQDHIYTNIKRGYMKLQKGKCIPTKLGETLAITLFQYTPELIEPTVRARIERAIQGIVKNGISPNRLIQEIKSEFEKYYNDLKKHRDEIRRALETVLNSKARERSGTY
(509) DNA topoisomerase type IA central domain protein [Pyrobaculum neutrophilum V24Sta]
3
MDLIVAEKRSVAQAIARYLGGSYKSGRLYGVPFYSFTYLGREAAALGLSGHIMDYDFTARENVWTWIPPEELFRATPVLVFRPETANYVKALRSLAKKAERVYLALDADVEGEAIAYEAALVVKLVNRRAEIYRVRFNAVTYRDVRSAFQKPTKLDLRQVEKVFTRMQIDLTLGAVFTRFLTLTVRNSLERGRFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVIKALVEIGGHAVEMASTERFKTRREAETAAASVKRGVVKTAVYRQHAVQPPEPLETVELERRASRWLGISSKKALDTAEELYRAGYISYPRTETTIYPSTLDLREVLKELAGGEHGPYAEELLKRGFKPTRGDSDDGAHPPIYPTRGATQGEIYKVFGKLGRQAWAIYDLVVRHFLATLSPPALVEKQRIVATFGGVELEAEGQRTIEEGYWRIYPWERQRDKPLPRVEAGEAAKAIRVEVVERETEPPPQMSESELLALMKKYGIGTDATMQDHIHTNVKRGYMRLQRGKCIPTKLGEALATALFQYAPELIEPTVRAKMEKALQDVVRGAAAPTRLIQEIKDEFERYYKALKERRQDLKTTLETALKSMSEDGSGGG
(1187) Reverse gyrase [Pyrobaculum neutrophilum V24Sta]
6
MDLPYVVYLHSCPNCGGPITSDRLAAGLPCRECMPKEPRAASLREVVEALRRRRALRELSWVADYLREYSDFSSFFARVVGYEMWGAQRLWARRLVRGKSFAVVAPTGSGKTTFVLVSALYMAGRGRRALLIFPTSALAHQAHRKLLGFAERAGLNVRVVAYHSLLGEKEREEALAAVERGDFDVLVVTSAFLPRRFDLLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDEVLKTALDAINLAKQLRKAEVAGDLKEAERLERELASLRAKLQEAVRGLKLGVFIASGALAKARRTTRLLLFREILGFDVGGRAEGLRNVVDLYVEAAHDVVQQTIDLLRRLGPGGIVYVQDRELGMAVAAKAREEGLAVEHFFRPRRGVLERFESGEVAALVGLGSSRSALVRGIDLPHVIRYVVFVGVPKFRFRVRLEEFSIPAYLTFLYNVRSVLAGEARYRADRLIGQLRRLAPYALSVQEALKKAAEGAELTGFDRHAVDVVKSAVEFVNGLLAREDIRRAIETSTEVKLAYIDGELYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVVVDDQKVFQALRRELKLRFDEAEFKHINEVDLGAVLEEVDKDRRAIRDIMEGRVSPAARGVDLLKTVLMIVESPTKARTIANFFGRPSLIIADGVPIYEVSTGDAVLMVTASLGHIYELPTSLKRVDPAQRAVLAKWFGDLKHDGYDAEEYAVIVKEEGFIPVYNKIWRCRGAVYVDDADVPADCRPLDVLSAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVSDIRRVEFHEVTRKAVLNALANPRGVSYPLVKSQIVRRVEDRWLGFGLSKLLQAKFSNQNLSAGRVQTPVLGWVVETYEESLRNRVYNVDLQLDDVDLRLQIPGDVLQVLRKKKRVAIRKTGEEERAVNPPPPYTTDEMLRDAVNKLGFSADYAMRIAQELFESGLITYHRTDSTRVSTAGIAIAREYVAKRFGEAAFRPRPWGEAAEGAHEAIRPTRPIDVEELRGLVNAGVLQLAVQMTRSHYLLYDLIFRRFIASQMEPSVVKVAKYAVEIDGHVLEIERAVDIVSQGFQQLYPVTAVEPELPTGTLDVAVKRYRVVRRILSQADVLALMRQRGIGRPSTYARILQVLAKRYYVYVAGRRKLMIPTKRGAEIYHFLRENFGSLVSEERTRLIEQHMDAIEVGKARYEEVLKELFDEFRRDVLPRLAYFST
(1045) DNA topoisomerase [Pyrobaculum arsenaticum DSM 13514]
3
MILIVAEKRSVAHAIAKFLGGRYKLEKIQGVAAYRFNYGGREAVALGLSGHLMDFDFTARQNVWTWIPPEELFASQPLIVYRPETMKYIRALRTLAARAHEVYLALDADVEGEAIAYEAALLVRLVNPRAKIYRVRFNAVTQREITNAFRNPTHINLRMVEKVFTRMQVDLTLGAVFTRFITLAVRHSLDRGQFLSYGPCQTPVLGIVVTRELQRRNFKPEKYYVVKALVEIGGHRIEMSADVRFKTRKEAEEAAATINRGVVKAAVYRPHHVNPPVPLETVELERRASRWLGINSKRTLDIAEELYRAGYISYPRTETTIYPPTLDLREVLQELASGHLGSYADELMRRGFRPTRGDSDDRAHPPIYPTRAATKGEVAKAFGKLAPQAWAIYDFVVRHFLATLSPPAVVEKQKIIVSFGKLEMEAEGQLVVDEGYWRIYPWERQSSKPLPRVSPGDPARAVKVDVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIHTNVRRGYMKITKGKCIPTDLGIALATSLFQFAPQLIEPTVRAKIEKALNSIVTDGTPPARLIYEIKKEFEEYYKALKARKEEIKKALETALNSSRNSQRG
(992) Reverse gyrase [Pyrobaculum arsenaticum DSM 13514]
6
MVPLVVYLHTCPNCGGPITSDRLVLGLPCRECLPEGTKAGSIREVVAALRRRRVLKGLAWVDAYLRGYEGFTEFFKKVVGFDMWGAQRLWARRLVRGKSFAIVAPTGSGKTTFVLVAALHVAKEGKKALLIFPTSALAHQAYRKLLVFAERAGVSVRALAYHSLLSDREKKEVLDAVQRGEFDVLVVTSAFLPKYFDMLKAFKFDFVAADDVDSILRATSKNIDRILRLLGVSDSVLSTALEVINMTKQLRKAEVAGDLKEMERLSQQIAELRAKLHEEARRLRLGIFIASGALAKARRTLRLMLFREILGFDVGGRAEGLRNVVDLYTEASGDVVEQAVELLKRLGPGGIVYVQDRELGMAILERAKAEGLAVEHFFRPRRGVLESFEKGELVALVGLASSRSALVRGIDLPHVIRYVVFVGVPKFRFRVRLEEFSIPAYLTFLYNVRAVLASDLRYKADRLIGQLKRLAPYALSVQEALKKAAEGAELNGFDKHAVEVVKSAVEFVNSLLEREEIRKAIETSTEIRLTYVGGELYVLVPDVTTYIQGSGRTSRLYVGGLSKGLSVMIVDDAKVFQALRRELKLRFDEAEFAHIKEVDLDKVLQEIDRDRRIIRDIIEGRVAPERRSVELMKTVLMVVESPTKARTIANFFGRPSLLVAEGVPIYEVSTGDTVLMITASLGHLYELPTSLDRIEARQREMLLKWFGDFKTDGYDGGQYAVLVKEGAYIPVYNKIWRCRGGVYVDDVDVPPECKPLDVLEAIRNVAVEVDTVLIGTDPDSEGEKIAFDLYVSLRPYVQDIKRVEFHEVTRRAIINALANPREINFSLVKAQIVRRVEDRWIGFGLSKILQNKFQNPNLSAGRVQTPVLGWVVKTYEESLRNRMYNVDLQLEEGELRIQISREALDVLRKKKRVAIKLAGREVRSLNPPPPYTTDELLRDAVARLGLSADAAMRIAQDLFESGLITYHRTDSTRVSAAGVAIAREYITKRFGEDLFKPRTWGEEREGAHEAIRPTRPIDVEELRGLVNAGVIQLAIRPTRAHYQLYDLIFRRFMASQMGPSTVEVAKYQLEIDGYVVDIERVVGIKEMGFQTLYQVSRVEPELSTGTIDVVIKRYRVVRRILSQAEVLALMRQRGIGRPSTYARILQILSKRYYVYVTGRAKLMVPTKRGIEIYHYLEEAFGPLVDEERTRLIERHMDMIEEGKAKYDDVLNELFTEFRKEILPHLSA
(1360) DNA topoisomerase type IA central domain protein [Caldivirga maquilingensis IC-167]
3
MDKLIVAEKNSVAKAIAQYLAEGGYTLRRIGIVPVYFFKVNGEYWASMGLRGHILDFDFEHSYNNWNRVEPGKLLDLEPVMVIRGWDRPYVTALVELSKQAREIILALDSDVEGEAIAYEVMLVTRLRKPTLRFRRALFSAVTRDDIRRAFSKLTTINVNLARKVFTRMVIDLKYGATFTRLLTLSAKSSKAPLNRGEFLSYGPCQTPVLNLVVQRALERENFKPEVYYKIKLIIEANGELIELESIDKFKNLKEAQEALSRVKAGKAVVKNIEAKRVHVNPPKPLETVELERRASRFLNIRSKQTLDAAEELYRQGYISYPRTETNIYPPTLDLRGILRNLTSTSTYGQYARHLLAGELRPTAGKDNDNAHPPIHPVKAADKPELMARFRDFKYWLIYDLVVRHFLATLSPPALIEEQRLTVDAGGVLFEASGLRIINDGYFTIYPFERPRANPLPLSALRIGMQVTVKDAKVVKRKTTPPPYLSESELLRLMRKYGIGTDATMQDHIHTNVKRRYFKIIKGQCVPTPLGKALITSLSKYAPTLIDPNFRSRMESMLSLIGSGKEMPDSVRRRLEEEAARVYTSMKPNSNQLGEELAKALRSMVNEKGA
(4) Reverse gyrase [Caldivirga maquilingensis IC-167]
6
MRDNKGDGGSGEPLVLYHGMCPNCGGPVTSDRLRDGLPCHVCLPEGSRLRAASLRVVLSELNREGRLVRLRDIFNYLMKYDEFSELFRKATGTSMWGAQRFWAKRLIKGKSFAIIAPTGSGKTTFGLVASIYVASKGGRVLMVFPTSTLAYQVYKRALTYRDSAAVNIKVITYNGLLSEKDKSEVLNAIKAGDFNILIVTNAFLPKGMEILSKYRFDLVFVDDVDSVMKASSRNIERLLQLLGVPREAIDKALEIAKISDFKEREGKVSELRRILEGRRIGSLIVSGMLTRTRRTARAALFREILGFDVGGRAEGLRNVVDLYIKPKGDLKVIILDLIRRLGDGGIIYVPTDLGREFAEELSKFLNDNGINAGLYLKPKRKLIEGFEDGSIPVLIGLATSRSALVRGIDLPHRIRYVVFAGVPKIRFRLSLKEFNPGRYIMLLSSLRVIAPSEYKTRIDKTVSSLRNIMNLSQDRINKIIEAIERGESLQGFDKYASEVISNAIKLAQDLLNRDDVREAMSKSIVNIQRMGDDIYVILPDSPAYIQGSGRTSRMYLGGITHGLSVLIVDNEAVFNSLSRDLRYRLVDFQFINYEEFNVDALLKTINEERELIRQIMTGNVPQSISQVDPLKSVLVIVESPTKARTIANFFGKPSTRVLGSLIVYEVTSGNLLLNIIATKGHVVELATEQYAQSVSSDVDYVTKFISSVTRNYYSVLKIDGNFIPIYSTIKRCPTCGRSFTDDVSKCPFDGTPLVDSSGVIEMLRDLATEVDLVLVGTDPDSEGEKIAWDVFNMLRPFVQDIRRIEFHEVTKRAILNALANPRGVNGNMVKAQLVRRIEDRWIGFGLSSYLQRAFNDRNMSAGRVQTPVLKWIIERYIEYRRNRVIRLIVRKRISDGKVLEVSFDKVTNGDETARVRHDLRDVAKDKKGLRIIITKLSESEEEVNPPPPFTTDSMLTEATARLRAGTEEVMRLAQELFEMGLITYHRTDSTRVSAVGISVAKEYLTNRFGEGVFTAREWGMGEEGAHECIRPTRPIDSEELRSLIDSGVLKLKLTNRHIALYDLIFRRFMASQMQSGLVKKVKVEVKLMRNGDMLSSRVDEFVTSVIRNGFLAIYPTIRVTQFPESSMELPVTEEDEVIVKTVHTTYPYREGDIVAEMKRRRIGRPSTYAKIIETLKRRGYVKALGSTKVLIPTKRGVAAYICLSNDKDVAKLYLSTRRNKVQENTEFESLLKQCNVNFKCLISEDRTRMVEEHMDNIENGDEDYLTVLHELFNEAVKYGIMPQN
(510) Reverse gyrase [Pyrobaculum sp. 1860]
6
MDIPLVVYLHSCPNCGGPITSDRLALGLPCRECLPEGSKAASIREVVAALRRRRALRGLAWVDAYLRSYEEFSAFFKEVVGFEMWGAQRLWARRLVRGKSFAIMAPTGSGKTTFILVATLYLAGGGRRALLIFPTSALAHQAHKKLTAFAERAGRRVKALAYHSLLTEQERREVLEALERGDFDVLVTTSAFLPRRFDLLSRYKFDFVAADDVDSILRATSKNIDRILRLLGVSDSVLNAALEVINLAKQMRKAEVAGDLKEVERLDQQIASLRARLREEVGKLKLGVFVASGALAKARRTVRLLLFREILGFDVGGRAEGLRNVVDLYAEAGGDLAGQVVELLKRLGPGGIVYVQDRELGETIAERAREAGIAVETFFRPRRGVLERFERGELAALVGLASSRSALVRGIDLPHVIRYVVFAGVPKFKFRVRLEEFSIPAYLTFLYNVRSVLSGDLRYRADRLIGQLKRLAPYTLSVQEALRKAAEGGELSSFDRHSVEVVKSAVEFVGDLLRREEIRRTVETSTEVKLAYINGEMYVLVPDVTTYIQGSGRTSRLYAGGLSKGLSVVLVDDAKVFHALRRELKLRFDEAEFRRLDEVDLGKVLEEVDRDRRAIRDIIEGRAAPAATGVELMKTILMIVESPTKARTIANFFGRPSLIIADGVPIYEVSTGDAVLMVTASLGHIYELPTSLARIEQRQREVLAKWFGDFKHDGYNGEDYAVIVTKSGFVPVYNKIWRCRGGVYVDDVDIPQNCKPLDVLESIRNIAVEVDTVLIGTDPDSEGEKIAFDLYMGLRPYVSDIRRIEFHEVTRRAILNALASPRGVSFPLVKGQIVRRVEDRWIGFGLSKVLQERFGNPNLSAGRVQTPVLGWVVKTYEESLRNRMYNVDLQLDDVDLRLQIPRDVLDVLRKKKRLAVKLLGRESRVVNPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDSTRVSTAGVAIAREYIVKKFGEGAFKPRTWGEEGEGAHEAIRPTRPIDVEELRGLVNAGVIQLAIQPTRSHYQLYDLVFRRFVASQMEPSVARVAKYELEVDGHVLTLERVVDIERQGFQVVYQVTPVEPELPTGTIDVVVKRYRVIRRVLSQADVLALMRQRGIGRPSTYARILQVLAKRYYVYVTGRSKIMVPTKRGIEVYHYLENTFSKLVDEERTRLIEQLMDAIEAGKAVYEEVLQELYNEFKINVLPSLSKT
(215) DNA topoisomerase (TopA) [Pyrobaculum sp. 1860]
3
MILIVAEKRSVAQAIAKYLGRSYRVQRIHGVPVYSFSYGGREAAALGLSGHIMDFDFAARQNVWTWLPPEELFNATPLLVVRREALDYVKALRALAAKADEVYLALDADVEGEAIAYEAALVVRSVNKRAPIRRVLFNAVTPREITAAFQRPTKLDLKKVEKVFTRMQIDLTLGAAFTRFLTLAVREHLERGRFLSYGPCQTPVLGMVVTRELQRRNFKPEKYYILKALVEVEGHRIEMSSDVRYKSREEGERAAASVKHGVVKTALYKPHEVEPPEPLETVELERRASRWLGINAKKTLDIAEELYRAGYISYPRTETTIYPQTLDLREILRDLAETEHGPYAEELLRRSFKPTRGDSDDGAHPPIYPTKGATKAEIMKIFGKAGAQAWAIYDFVVRHFLATLSPPALVEKQKIAAAFGGVEMYAEGQRVISEGYWRIYPWERQRDKPLPRVSPGAPARAIKVEVVERETEPPPQMTESELLALMKKYGIGTDATMQDHIHTNVKRGYMKLAKGRCVPTDLGIALATALFQHAPELIEPTVRAKIEAALNSIVRNSTPPPKLIAEVKAEFRTYYENLKARREEIKKALLNALNTHRQ
Family distribution
Taxonomy tree
Thermoproteaceae