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Taxon : Desulfurococcaceae
Informations
Name
Desulfurococcaceae
Rank
family
# topoisomerases
24
Lineage and sub-taxa
Lineage
Archaea
>
Crenarchaeota
>
Thermoprotei
>
Desulfurococcales
>
Desulfurococcaceae
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(75) Reverse gyrase [Staphylothermus hellenicus DSM 12710]
6
MVELKHIHGYYRYSCPNCAGENSDLRLIYKAPCDKCIEEELFDQIRENISKKSYKEILETYYKVLQKHNKLKKRFESLYKFEEKLEKFEEFFSRATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYLSKKQIMIQKNRASRKKVYLVFPTTPLLLQAEKKLRKLAEQARIPVCQEENHDQTCLNIISIHGRVSKKKREKLLEEIKSGNFDILLSTNMFMHRNYELLLGKKYELIVMDDVDAILRSGKAIRILFYLLGLTDQEINEAIEYLKARQRLAFRLSEEKRRELEQKLETLEKRIEKYKRKIGTIVIVSSATGKPRGIYPRLFRILLNFEAGSKAEAIRNIVDTYTYPEESIEQTIIKLAKKLGNGGLIFVPIDKGVEYAETIAELLKKNGINAEAFHAKKAVKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFSTRLETPSPTDVLRIFTILRDVLEGEEKRKAEILIGRISLRLRRLSQGALMKLKEDFIKKLQGEEVEEYPLLSMLIEALSMARELLSKPEIWEKLKQKGDVALIQEDGKSYILIPDVATYIQASGRTSRLYPGGITKGLSIVIVDDQRLLNGLTKRMRWLYEEFDMRRLDEVDLDNLMKEINEERRKVKMILEGKIEAEKTLELTKSALLIVESPNKARTIANFFGKPSIRILENGMPVYDVTTGDYVLSIIASIGHVYDLVVDDGLYNYGVRLVGDKFVPVYTDIKRCNKCGYQFTAETNTCPKCGGRDISRKLDIVETLRELANEVDTVFIGTDPDTEGEKIGWDIKVLLEPYAREIKRVEFHEITRRAILNAIRNPRDFDMKLVEAQIVRRIEDRWLGFALSKKVQKYFWPKYCVEALIPSLYKMIRKKKKKIEKMPNCCVENRNLSAGRVQTPVLGYIIERYRDHNDVSKYKYLLTIKIDDNRLRVDIDRSVLENIGTTSPRDLIGYRVEVLEGDRKEEIINPPPPFTTDTLLEEASMRLGLSTTRTMEIAQELFELGLITYHRTDSIRVSDAGINVAKQYLEEKLGEKAKEVFKPRTWGTGGAHEAIRPTRPIDADRLAELIREGALILARPLTRLHYLVYKLIFNRFIASQMIPAKIVKQILKIRINGYEKNVERVIGIIEKGFLEFYQTVNIEEEVKPGTYPIVDVEELKPPLARYHDVIKWMKIKGIGRPSTYAKIIQTLIDRRYVNVSKRVKALIPTRRGIMVYEEFLNKYYRDVVGVDVTRELEKKMKEVEEGVRDYQEVLWEIYNELRTKIIDNPIVNKELERQWSMYCGQTEYSK
(1720) Reverse gyrase [Staphylothermus hellenicus DSM 12710]
6
MEKILDPIYKNLCPTCSGDVFANSLWDFGVCGKCSGETRNSFNALTLYRAFKEDLEDFTSFFRKATGNLKPWGAQLTWVKRLLNGENTVIVAPTGMGKTTLLVVYSVYVAKNYGKKVLFFAPTRALAKQIYNRIIEAAENVCGTCINILFYDSGLSKKRREEILLKIKNNEYDILVLTNHFLNRHYDLIDPSHIGLIVIDDVDSLMRSSKNILRLMKLLGFHEELIEKAKKRNSIIWKLMLSKSLNKEEDYRRYIEELIEIEAEIDKLLRNTSRKQVVIASATGRMKGTYAKVMRDLLRIDVSGITVYGRNITDTYLLINDYVSDADNIIEVIKILGPGALIFISPRHPLKKKLLELVKLLREKLEERGYRVAEANPSTIKKFIRGEYDFLIGSSSYYGVSVRGIDAPETIKYVLFIGTPLFTVELGSFLASPNMLIRVSLMLSEVLGDQRYRGMASAIRRLVFPLNSGEIKLLSMLLKNKITINDLGKDSRVAKVYEQILGFYNEIRKSLEELLSKKKVVNMNTITFYHADNKFYALIPDVMTYIQASGRCSRLYLGRMTHGLSLVVEYEFLSNLVNGLSLKMNMFSHGFVFKDISNVDLYGERKLIEKTRRELKGPVLTYRNILVVVESPTKAKTIARFFGKPVRRKIGSISVYEIPFVKDSEVIHLNIVATRGHLFDLTTDPSIPNHGVLIEDHRISPVYTSIKRCRICGHQFTYGDRCPRCGSTSFTDSYEVVNVLRKLAQEADEVYIATDPDIEGEKIAYDVYLTIKGFVDKVWRIELHEITLNEFLNALENKRDINRKLVEAEIYRRVLDRIIGFSLSQELWRKYSKKWLGAGRVQTPVLGWIIDHYNEYVSNKCRKIIYITEHKGFKFSICIDLKDKDLYKEMRSVDHVTLVLKNSRIETFNPPPPYTTDELLYDASRIGIPSSLTMKIAQELFESGLITYHRTSYHYVSSAGISVASKYLENKDLMKHFHPSHWGNKGAHEAIRPVHPLDREDLEKAVVEGIVAPTIPLTWLHYRVYDLIFKRFISSQMNPYKALIGEYDVVINNKVVKTLVLPIEIVEDGFNIIMGSKTYSFLKGHDRVNISIKDIKAMVTSTKPLCSEGGLVKLMKEHGLGRPSTYSKIISSIVRHGYVIRSKKRGFLIPTKTGIEVYNYLSNSFPELVSIDTTRDMEMRIDLIAKGEMRAADEISRVLDRIRRYKLPLSIREVVAEASA
(1275) DNA topoisomerase 1 [Staphylothermus hellenicus DSM 12710]
3
MKVKAKKSIIDYILSYSKKQEKEHVKAEEKTLPRKVTEKAKIKITRNIWDLTGKIVVIAEKPKAANKIALALSKNPIRKSIYGIPYYMIKTKNGLIIVASAAGHLYGLHTDQYGYPVFRYEWKPLYQIGHKAKHTKKFITALSKLCSNADYYVNACDYDIEGSVIGYLIIYFHGDLEKSLRAKFSSLTIGELRESFRKLTSLDWEMIEAGLCRHELDWIWGINISRALMSSVKMASGKRVILSAGRVQTPTLRYIVEKDIERRLFIPLPQYSLSINISKNNYEIHVEYKGKAVETKKKAKEIIKDIKNTGYLTVKKYEEKKYWLNPPPAFNLGDLQEEAARIYRFSPYKTQSIAEKLYLDALISYPRTNSQKLPPTLNYKGIMNKLSRINNYKELISNLLVETRGVLKPVQGPKDDPAHPAIYPTGVKPKDLGKDEWKIYDLIVRRFLAAFASRARISHRIVYLEYPKDPSMVFMASGRKILELGWLRYYPFSMPEERFLPRFQHGEKVKITKASIRKTYTKPPEKISRIKILRWMENVGIGTEATRARIIEILFNRKYLRSVGGRVEATDLGLGIIEVLMEYFPEITSVSLTRYFEGEMEKIRLGIRRRDEVVRDAKNTLIKLIVSFDKKKYQIGKTLSYRLGYLTPTNKCMLCNREAYKNNLCKYHYQALNTIVKTYEEWKRREGVDWDKYLSSIKKLKSTGKWIVEVIQNFEKIKYSHSK
(1708) DNA topoisomerase [Ignicoccus hospitalis KIN4/I]
3
MKGHILVIAEKPKAAEKIANALGKPIVKRKYGVPYWELTNGKKIVVVPAAGHLFGLAPLGKGFPVFDYEWRPLYEIEKGASHTKKYIALISSLSPGSSLYVNACDYDVEGSVIGYIIIERFGDPRRSKRMVFHALTPDEIRRAWNSLRPLDWEMINAGLARHELDWIWGINVSRALMHAYRVATGKSKSLSAGRVQSPTLKEVVERELAVQCFVPEPYFSVSLSAKGVSLEPTLKFETKDEADHFISNCLGKVVDVIVNDERLSPPHPFNLPDLQMEAARLYGFSPSKTQSIAEELYLDAYISYPRTNSQKYPKDLDYANILKGIASVPQYRPLTKALFKETRGRFSPNNGPKDDPAHPAIYPTGKPPKNLSPDHMKVYDLIVRRFMATLASESVYEVTKVVIEVNGQTFKAVGRRVKWKGWTLYYPFSAPQEKSLPSFTKGESLQVKCTRRLQYTKPPERYTKAKIVKWMERVGIGTEATRARIVETLFKRGYLKNVGSKVYATDLGIGVALVLSKFFPEIVSVELTRRFEEDMKKIMMGVERKEKIVEEAKKFMRMILAKYKPHMREVGEYLAYSLGEMEPPGRCAVCWRVAEEDGLCVVHKRARDELYAKYPVWRRRLGLSFEEYLKKVTTLKQAGTAAKEVAKALLSEPTFKG
(1264) Reverse gyrase [Ignicoccus hospitalis KIN4/I]
6
MYASYRRSCPSCGGEIEDVNLSLGLPCDKCLRVVGLESLKLDPSKKDSPSVRRRLIELGGPLGESLKLEEELESLEKVFQEVLGAPMWSAQRAWALRALRGESFSIVAPTGMGKSTLGALLSVYLSHKKKKKSYIIVPTTPLVDMMFRKVSAFAEAFGVRAVYFHSKMSPSQRKEMKERLLSGDFDVLITTSRFLINNLDLLKNYEFGFVFVDDVDSVLKSPKNVDRILMVLGLQESDVKRLEEVDKELSRKAQVLTKLQDLQKRYQLLKEMRELEEELEDLKRKVKGNLIVSSATGRAKGNRVRLFTRLLGFTPGGVGEGVRNVVDSYSRSSDVVEVVKKLGKGGLVFVPADLGAKGAEEVAEALRAAGVAAEVATSERIGVIKDFEEGRVEVLVGVATHYGVLVRGIDLPHVVRYAVFVGVPRFKFKLKLEEPSPMTIYRLCSLAARFFEECASLYAKLRKWVQRLGPAGLQSVEEALKEGSASTPASKDFMEAYTKLKEIIEKTDFIEKLKESGEVDVVAEDSLYVLIPDAATYLQASGRTSRLYAGGVTKGLSVVLVDSEPLFRGLKKRLAWVVEEWKEFESLNLSELLKEIDEDRKKVLKVIRGELKVEEVRDLMKTVLMIVESPNKARTITSFFGRPSVRQVKGVKVYEVTLGDKLLYVAASGGHVYDLVEEADPCNEEPCMLFGIRVKDVPEEVLSSIKRCAVCGHQFSGDVKECPRCGSPFIKDAKDVVDGLRELAQEVDEVLIGTDPDTEGEKIGWDLKNLISPFAKKIRRAEFHEITKKAILKALENPRDFDMGYVWSQMVRRAEDRLTGFTLSPKLWFELWPQLCEVSKEMKKKLLGCPLTRNLSAGRVQTPVLGWVIQRYEEYAKSKKKFYIIRFDGRELEFSEDELRGFSKKLAIDGKVKILKVEEEVEELKPLPPYTTDTMLEDASKLGLDPSRAMRVAQDLFEMGFITYHRTDSTRVSDAGIAVAREWITSKFEGLFAPRRWGEGGAHEAIRPTRPLSAEDLKRLIEEGMITPPRELSKQHFMLYDMIFRRFMASQMKEAKVKKAVYEITVEEGGAVVGKKVLEKYVERVFDGFLLVYPIVKIESLPEGEYEVKEVRAVSRHTVPLYTQADLIRLMKERGLGRPSTYAKIVSTLLERRYVTLSKVGKKLVPTVRGYAVYSYLTGKVVGAGWVRKALEVIINPEGKSKYFQKLVEEEATRRLEKVMDEIAEKKDEKMYINVLKDIIEETKVIPFLSDKGAQPSLR
(1683) Reverse gyrase [Ignicoccus hospitalis KIN4/I]
6
MIEAVYQRSCPSCGGDVERERLLAGLPCSKCSEPRGLLAWKEVLEEEYEAFANFFKKAYGFELWGPQRAWAKLALSGSDAVLLAPTGTGKSTFLAALSSFLKRKGKRVLYVVPSKSLEEQVKERLAEEVDVITMRRLVRDPRAYRGYDVYIFDDVDSVMKSPKSATALIIALGLEEAVPIVNEMVDIIKKGLSDEGRRGRYEELKGELERLKDKKGSQVIMASATAGGGSLTAKLILSLLGLSPASAPPAIRYVDDVKMFHEDPVEGAAEVVRYFTSEGLKGIVFVHEGFPIEEVERALRERGVAAEVVKSGKLKALKKLEKGELDAVVAYSSRYGVAARGIDMPDVIRFAVFVRPPFKKFDLERGLNNPLTLLRVMKKLEMKEDTVKLFKMLSKLSEVELALLRRAMEEGGELEGFLGDALSALKEMKGKVLERLKGEKVVDKGFVVKDGKVFLLDPKTYLQASGRTSRLTPKGMTHGVSVVVYDDEDLMKAFEESLKDRVEFKEELVTPKGPKPVKAKNVLIVVESPTKAKTFARIMGGGGKVEVGGVAAHLAVHEFGGEALFAFIVATKGHLFDVTLDEVGTYGVELGEPVRVYYAPINRCRRCNLAWASSDPRCPKCGLPAESSSKVVEALRRLATVVDEVYLATDPDEEGEKIAWDVMAMIYPFNSNIKRMKYYEVTLRGLHEALSFLTTVDEGTVRSQIVRRLDDRLVGFAVSERLKAAFGDPNHGLGRVQGPVLKFVVERAKARKASAGYSVTLHLSNGDTLRLFVKTKEEALKLASVEEVKILKVEEEVEELKPLPPYTTDTMLEDASKLGLDPSRAMRVAQDLFEMGFITYHRTDSTRVSDAGIAVAREWITSKFEGLFAPRRWGEGGAHEAIRPTRPLSAEDLKLDFALNGMSFEALRLYDMIFRRFMASQMKEAKVRKVKVVYEVAGKRVESAWVAEILEPGWTSVWNIKTKDIKLEKVAKVVSSEVRRASLVQLPKVFEVIRWMKERGVGRPSTYAKTVENLRRHGYVVITPNNYVVSTKKGVAVAEYVERNFPELAEAEYTRRLEEAMELAKSDFWGAFNNTLRAFRALASLES
(597) Reverse gyrase [Ignisphaera aggregans DSM 17230]
6
MSGINIVFDLGGKGDEELLKIPRGIYLGLCINCGGPIEDNRIIYRNACSKCMNSKDLVEVRDLEELAKHVTSLNPNGRLNYILTLNKFVKEFEEFFQKSIGSKPWSLEISWALRVAQHQSFAMIAPTGVGKTTFGLVMTLFLSYKYGKKVYIIVPTTVLVEEYEKRLWQFSEKLGITLKIIAASSKIHGKRKIELEESIASGSFDILITTSAFLQRNFNDVFKKMLSNNIKMDLIFVDDVDAIIKGSKAIDMVLQLLGFSEEDISNGYKMIDLRRRLLQCENARESSRCYIDGKPIDVIYEELQKKVLEKRERCGILIVASATGRARGKRIKLFRELLGFSIGTAIEVNRNVVDAYIPIDNPAEIIDRLVSIIKILGSGGLIYVPLDLGQEYAVKLATELNSRGIRAGVVISGKSEDLKKFIENELDVVVGVATYYGLLVRGIDIPERIRYAIFVGVPRHKISLTRIEYYPQTLLRLLSVLVDVVEDQMKDRVLRNIAYLRRILRRISPNRIFDIVERLKKGEKVEDELAGIITNAYKLVNELLSDSKIIDRLKKHERVSIIEEEGQLYILIPDAPTYIQASGRTSRLFMGGITRGLSIIFVDDTRLLRGLEERIRVYIDDFRFQSFNEINLEEILKQIDEDRRIVNLIKRGLLEEVIHIPKFSFSRSILFIVESPNKARTIASFFGRPTIREIDGLRVYEVDIGNAHLLIASSGGHVFDIVEEELSENNIYGVQRTVENGKQLFLPIYGYLKRCSVCGAQFVKGTVCPICGSTRIRSSEKIINALQKIALEVDEVIIATDPDSEGEKIGYDMAIALAPYAKIIRRAEFHEVTRKAILSSLYNPRGLKLSLIEAQIVRRIEDRWLGFALSDYVTKRFKELKLESREGRLSAGRVQTPVLGRVIEIYINRLRTQRKYKIFSIGNISLEIPVEDLKKIFGDELKRISKERVEIVLKLLSHEIVNLNPMPPFTTDELIVEAQRQLGIDAVETMRIAQDLFELGFITYHRTDSTRISSTGISIAHEYLLNKFGDLGKELFVPRTWGEGGAHEAIRPTRAMDVDMIQEIIAEQLIELPIRLTNRHLRIYDIIFRRFIASQMKSAKVERNRFEAILKIDGIEVAKQHIEIISNIVEPGYTLIYMPFKTVFLPHGSIALKPLHIKTAILSDVKLPTQGDLVKWMKDVGIGRPSTYAKIVEILLRRGYTFRHRKGSVLIPSITGIIIYNILAGTMLPSIEVDEEEFINILQKHPSIRKYNPEALRQTLAEILRNLSIGIRNMVSVERTRMLYNKMQEIEEGRLSYINVLSELFREMCSNVINMISSEAIEICKS
(1762) DNA topoisomerase [Ignisphaera aggregans DSM 17230]
3
MNIKDYILVIAEKPKSAEKIAYALGNPKKYRINGVPVWFVMRGTSRFVIAPAAGHLYTLHTESKGFPVFDYKWVPKYIVEPESIFTRKYLNVLSMLAKNAKEYINACDYDIEGSLIGYMIIKNIGDIKRSKRAKFSSLTASEIVRAFNNLLPLDYNMIEAGYCRHILDWLWGINVSRMLMSIYRSVFNEKRILSAGRVQSPTLSYVVNIDLQRKTHVPVPYAYPSIKIFIDNKIFKLIPIDSPFNSLSDAKEYLENIKRDPRATVLDIIVRDERIEPPHPFNLPDLQSEAHRIYGFTPYKTQKLAEDLYLEALISYPRTNSQKLPPTLNNREILEKLSQNIVYRTLVKTLLAETRGILRPNNGPKEDPAHPAIYPTGEGTLKGLSKDHIKLYDLIVRRYLATFANPAVVQYVRIEFIVHGRRYYLSTNIVRSRGWLQYYPYIHFNGEEISLKLLRKGLQIPIHEAKIVIHFTKPPHLPSKISLVKWMEEKGIGTEATRAEIVETLFKRGYLYMRGRGSGVSELGILISFLLKDYVEELISVELTRKFEERLNMILNMKAKCDDIVEEAKEMLLKYINRVKSLDIQTLRAEISKYIEMSDNNGRRCMICKRSVYANNLCIFHNIALENIRSAYETWRKFGFSWTQYLEKLLKLKSTGSYVKEVCRHLIKQGEF
(919) Reverse gyrase [Ignisphaera aggregans DSM 17230]
6
MTLAIYRHGCPYCGSSIYVGEDSWSCENCEMINRFRHGNSYVDVWFKEIRDFIEFFRMATGFSPWSLQTYWIKRLLSGESFAMVAPTGIGKSTLLGVYALYRAYFYRSKIYIITPTREIAKQFYSKISEYLRTISKNFHGADKLRIIFYDSSSKNHKDILKLINENMFDILITSSSFLSRHHVIVDSSKIDIVIADDLDSIMRNSKSVDRVLKILGFDEKIVNLAMELVKLKQSFYVAKLAKSQESVENIRRKIIEMEAILKNEVAKRNTQLVVASATGRSAGMKALILKELLGFDSGAIFEYWRNIVDIYSQIDDKMMIYIKEIIEKMKSGIIFVSSPYKDYIDVIVKKLMDMNIKVAVVKSGNKAVDKFRRGEVDVLIGSSSYYGILVRGLDEPQRIKFVIFIGLPQIMKELWNSLSNIRLLYMIAKCLNEQGIDLSNDIKTLINIIQSSSPAQLILLSKALNGREYPNDLRDKVEELAKIRDRVYEEAKKFLDTNGKLVINNYGILVKLGHRYVILKPDPYTYIQASGRCSRLFNGIKTFGVSIVFENYKELIELMEKKMKRFVDGFRFINLSDADIDEYVLRAESTRSLNFSGDGTIDIRKGISTALIIVESPTKAKTIASMFGKPAKKVYGNVIVYESIIPISRDKVYVSMIVATLGHITDLVTDEGLYGVRVNNDRYIPIYDFITKCRRCGAQIVGIYDECPYCNSIDVQSSNTIYNVLKKLALEVDNIFIATDPDTEGEKIAFDIYNLLYPINKNLFRIEFREITKNAVLEALKNPRRIDIKRVKAQMTRRIIDRWIGFELSMVLQDKFNKPWLGAGRVQSPVLLWVARRYKEYIDSIGYILYCDLYGYKIKIYLGNNVDRNYVEKIMDRISNEGLEVKDVEIIERTIQPPPPFTTDSLLYEASNKYGYSASKIMAIAQSLFEQGLITYHRTDSTRISSLGLSIAREALAKENLLEYYVPRQWNVENNAEDAHEAIRPTNPINADELIELIMRGELGIITRISDDHLKIYDLIYRRFLASQMKPARVLVLRANIGIDKYFTNIEAIIDIIEKGFMSIYPLKIYPDLRNLEKTTFIKPNKIFVKKGSAIGLYRVADLIRMLKEKGIGRPSTYAKAIDNNIRHGYIILSKKVKATIPTKLGKEISEIIEQRYINLVGDKVTYELEREIDLIERGLRDMNYVLNRVRQAIDIIINTEGNNIIQLFSDTETVNISDNRVELISSE
(1174) Reverse gyrase [Thermosphaera aggregans DSM 11486]
6
MLTYVLNPLYRSSCPVCGGDLTSRDIEEYGKCSKCRSRLDSSLNVFTLNKIIEDEVEDFEEFFKTATKGLTPWGAQKTWIKRILSGENTVLIAPTGMGKTTLLVAYALFASSRGKKILYITPTRALGKQIHARISGDAGSEHSVFYDSGLSKRRKQTLLEKIGKGDFKILVITNSFLGRNFDLLSKHEFDIIIVDDVDSLLRSEKNILRLLLLLGFNEEVVQLAKKRLQLLWRLMVSKSLNNEESYYSIVKEYLDLDAKIEASLKTLKRRQLIVASATGRIKGLMGRILKDLLQVDVSGITIYGRDVTDSYFLRSLDEASRELAALVKTLGPGCVIYVSPRHPFKQQLVKLSEDLRSILEREGFKIADATPANVLKLVSRQVDVLIGSASYYGSGVRGIDAPQSIKYVVFLGTPVFTVSLDSFLSNPNMLARILIELAEKTGIKSLREKAYTVRRLVYYLSPGETRLLRNVLKGKIPEEAVKPHEKLYSKYVELKTLYSETIREVEKYLDVNTVLEAGSITLLKSRDGYVALIPDAMTYIQASGRVSRLYGGRMTHGLSLILETPLLSNLVKGLEMKLKLINKDLGFRELEELDLSVEKEMAESTRTRSGEWLLKYRSVLIVVESPTKAKTIARFFGKPVSRRIGDVNVYEIPVKIGEEIVDLNITATRGHLYDLTTDPYTDNYGIIVETGLVTPVYETIKRCRVCGTQFTHEASCPRCGSGVFSDQKAIVNALRKLASEVDEVLIATDPDIEGEKIAYDVYLAVLPVNSNVWRIELHEITLQEFLKSIERKRSVDRNKVLAEIYRRSLDRLVGFSLSQDLWSRFGKRYLGAGRVQTPVLGMIIQRYREYVEGRCRKIELSLGSPLNTKYSVCVDNNSSLVDEARRAGKILLRKEGEEVVEIAPKPPYTTDEFLVDAARRGIPVSLAMKIAQELFEAGLITYHRTDSKYVSATGVSIASKYLASKNLRNLFKPSHWGEPGAHEAIRPVYPYDADDLMKAFTEGLIPLTIPLTGLHYSLYDMIFKRFIASQMKPFKAVKARFSLWVNGISLGTMEVYTRIVEEGFNAVAGIKTHEALGSVEEAEVPVKEVKTSISSRTFLYSEGDLVALMKKTGIGRPSTYSKIISSIERHGYIVKSRKKLKLIPTKTGVMVYDYVSTAYPDLTSIELTRRMEDLIDEISMGRLNAAEVIMDLIQSLSTRSLITVKTVNTFSSQL
(625) DNA topoisomerase [Thermosphaera aggregans DSM 11486]
3
MNNIYSTIGRGPGFTSIWDLKGKVLVIAEKPKAARKIAEALSQRYFVRNINDVTYFEIRDGPRQIIVASSVGHLYGLTTQEEGYPVYTYQWVPLYVVEKKKAHSYNYLEALRKLCTTSNYFVNACDYDIEGSVIGYLIIKFNGDPGRAYRAKFSSLTLSELREAFRRLTQLDYEMIEAGLCRHELDWLWGINVSRAIMRTVESFSKKKIILSAGRVQTPTLKYVSDIEKERNLFIPIPVYSVVPTIVKDGVKITLELINSPIRTKKDAYALAERIRREGFLTVESYVEHTTSVAPPPPFNLGDLQEEAARIYGYSPSKTQSIAEQLYLDALISYPRTNSQKLPSGLDFKSLLTKISQISNYSALVSDLLKETKGYLKPVEGDKEDPAHPAIYPTGVRPVKLSSEQWAVYDLIVRRFLAAFAGNAIIYRSTAKFALPGENIVFQATGQGIEDLGWYKYYPFHKPSVKVLPRFRNGERVEVVEVSVKTAYTRPPQRISKIGMLRWMESVEIGTEATRATIIEKLFERKYLVNTSRGVAVTDLGLGIVETLEIFFPELVKVELTRHFEKLMNDIKKGVVKREQVITEARNTLDMLIKKFNEKKETVGQILSSRLGIYTPPNKCAICNREEFSNGLCTYHYKANEQINKVYEEWKEREGVSFKEYLERIKKLKSTGKWVIEVIEHFYGGK
(221) Reverse gyrase [Thermosphaera aggregans DSM 11486]
6
MSNLLNPYGFYRHACPNCGGEISDHRLFYKAPCEKCLSEGDFKKTLKRIRSEGLRDYKSIIEAYYKDLKNPEGLRQLLDEEVALEDFEEFFERATRGNKLWSAQRTWARRVLKKKSFSIIAPTGTGKTVFSLVISLYTVAKSQRGDRRRVYLVFPTLPLLLQAESKVKHFATNAGLKICEDRAEESCIRILVAHGRSDKKSKEELMEQVRNGDFDILLSTSAFFHRNFELLKNKDFALIVMDDVDAVLKSGKAIRKLLNLVNVTDDAINDGLNLIKLRQRIVFSSGEEKEKLSAEIEELEKKIARVKSEIKTTLVVNSATGRPRGIYPKLFKVFLDFEAGSKPEAIRNIVDAYIEADDPENALLEIASKLKDGFLVFVPVDRGVEYADKIAELLKAHGLKSESFHAKKKIDVLNDFARGELNCLVGVATYYGVMVRGIDLPERVKYVIFLGVPRHKFSTALEEISPTDLLRIISVLRDIAPEESKRELESLVGRLSNRLKRISQGALFKLREDFAKRLKGEHVEETVLIKELLRAYELARELLRDEEIWRKLSNLGDVGLLWENGRQYLLIPDVATYIQASGRCSRLYPGGITKGLSVIIVDDKRLLNGLNKRLRWIFEGVSIANLRELELEKLITEIEQERVIVGKILRNEYRPEGQVDLIKSALLIVESPNKAKTIANFFGKPSVRVLGKSLQAYEVTIGDYVLSIVASAGHVYDLVVDLQENYGVRRVGSRFIPVYTDIKKCVNGHQFVDETDKCPRCGTSRVVRKADIVSALKELAREVDLVLIGTDPDSEGEKIGWDLKVLLEPYAREVRRVEFHEVTRRAILEAIRNPRSFDTRLVGAQIVRRVEDRWIGFSLSEIVQKYAWTSYCFENLKDKGHDCCRENRNLSAGRVQTPVLGYIIKRYRDKEDKSLYKYRLLAEKDGEKISFTIDRAQAVNAGLVSILEKNNKRRKKDKNYPPLVIKERELIVEAKNPPPPFSTDALLEEASKSLGLATTRTMEIAQDLFEMGLITYHRTDSTRISEAGLTVARQYLEERYGDKYRDVFQPRTWGEGGAHEAIRPTRPIDADRLAELVREGVIVLTGRLTRQHILVYDLIFRRFIASQMKPAKIGKQVLTVSINGVEAVVERVVEVVEKGYLEVYQDVKLETRITEGEGRITEVVEVKPPMARYHDVIRWMKENGIGRPSTYAKIIQTLLDRRYVDVTKKHKALRPTERGIFIYRFLDEKFKEVVSVETTRRLEKDMSDIEEGRVEHMKILEKLYNELREKILDNPIIKELEDEYSERCGRKSDAA
(1831) Reverse gyrase 2 [Aeropyrum pernix K1]
6
MPGGVNAVYMGLCYNCGGNIDEDRLEKGLPCARCLPSPPRRATPLTVYRALKKAGTLGAYSWEYLSIREVERFEAYFAAKSGSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYVAAVKRGRVLYLVPTENLVRQVYAKLDQVEPGIATAYYSRMPAKARESSLEKIASGGARLIVATTGFLSRRFDLLHPQYKFDLAIVDDVDSLLRNSRNVERILLLTGFSEETVEAAHSLVKARLKLYRALHSGASESIVSRLEQEIAQLEARLRLSLSEASPGQLVIASATGRPRGVKHLLFKELLGFEVGGGSDYLRNIVDAYVVDSDPVGRTAEIVSALGDGVIVFVSQRLGKDVARAIAGRLEGMGVSTALALTGARRPVEAFARGEARVLIGMASRYGVIVRGLDLPERSKYAVFLGAPSAKTHLLEALYSPRRMLAFLSIAQEKGVEWAGEAFRRLSRLLEKVIDTSIVSLAARGKLEAQGPAGEAAGIISETAPRLVDWLVAEARLQGGLLRVGGLVVDARGPIPYLVVPDAPTYIQASGRVSRLYRGVMTRGLSIVVDEAPEYVEALGERLKWTTSSRLRPLSEVDMEKLRREIEESRRGKGRRVRVKTTLLVVESPTKARTIAWFWGRPGKRRIGRSVIYEASVSDPETGDVHILQITSTRGHLTDLTTDSVGSKYGVDEDGGGYRAYYSTIKRCLDCGAQHTSSSPFCPRCGSPRQVDSKSVVEILRKLASEVDEIVIATDPDREGEKIAWDVFLAVRPYNPNVRRGRFHEVTPRAVIEALRSGESVEKSLIEAQKVRRIVDRWIGFHLSTHLKLKFSKPWLGAGRVQTPVLGWIVDRYREWQDTRGYLVIFKLSSGGRTSYFTQNRLEVENLKRVEWLEVVDIAGKTEERNPPPPYTTDEYLYDASRKLGLSAGLAMKIAQDLFESGLITYHRTDSTRVSPTGVKLALEYLASRGLEGEAQPRGWGEGGAHEAIRPVRPIDAQDLERAVLSGSIRIPIRLTRLHIRVYDMIFRRFIASQMKPATLDIVEATLQAGETVFNHAGVARVRGGYALVNPPRVEEWLARLSPGDRIDVEDVLVVKSSLKRLYRAGDIVKMMREHGIGRPSTYAKAIEQNRRHGYVIESKKMRYLIPTKTGVSIYDYLSNGFKKLVSVDTTRRLEEALERVEKGVEKPEAVLASVWRMVDEAVSLHAATGDVMGQSEA
(1272) DNA topoisomerase 1 [Aeropyrum pernix K1]
3
MVAEKPKAAAKIAYALSDGRGVLRCSEYGVPYWIVRRDGAAIVVAPSAGHLFGPHTDSRGFPVFDFEWRPIFEFDRGAGYLSKFYRMLSRILPGASLYVNACDYDIEGSVIGFKIIEAFGDVNRARRMKFSTLAPQDIRRAYARMERLDVEMIEAGMARSEMDWLWGINVSRALMEAARRAAGRRVILSAGRVQSPTLVEAYRRWREINLHVPKASVAVKITAEKGGGVFDARPHGWKPQSLETARSIKSELRKNPWLAVEEVRSERSILRPPPAFNLGDLQKEANRILGLPPLRTQSIAEELYLEALISYPRTNSQKLPPSINYRAILDKLAHGPLGREARELLKETGGVLRPVQGSKDDPAHPAIHPTGEKPSQRLSKEHMAVYELIVRRFLAAFSREAIVSKSSVLLRDFQGRVWRAEGLRVEDLGWLKYYHYSTPGEKPMPPLDRGDKARVVRVDVRVEWSQTPVRLDKASLLRWMESVNIGTEGTRARIIETLYKRGYLEGSRKSEVTPLGEAVAVIIQTLFPELSKPDLTRRFESMIEDIRSGRRTRQEVIDMSKKTISKLLESFLDRLDTAVREIGVSLGSVEVEAACHLCGRKAVSAVSGYRLCSHHMEAFDRLRKALPNLASTISSTPREALEAIARGRSRAGAWVRDVAALALRDDGLYKALL
(1407) Reverse gyrase 1 [Aeropyrum pernix K1]
6
MASARAASRGVYRYLCPNCGGPNSEERLSRGLPCPRCLPRLPRKGVSGWTGLARLLRREGTLGAGVKAMASLEEEARSLWRFFEKAVGSPPWGAQRTWAKRLARGDSFSIIAPTGVGKTTFGAAASLFYACKKGMRSYIVLPTTTLAANVARKLESMVESTGCGRVRLLVIHSKLKTSERREAMERFEKGDFDILVTTAAFARKYADRLSGYRFRLVFVDDVDAVLRSARSVDAILKIVGFDEEAIEKGLEVLRLQREQARLVGLLQSQREEVREEARKKLLEVKRRLERLEAEIEARRGRTASLIVSSATGRPRGARVRLFRVLLNFEAGGRGDIGLRRVIDSYTHPTDGVAEKVVELVRRLGTGGLVYVPIDMGVEYAERLAEELRRAGVKAEAYHAKKPLELLDRFAEGEIDVLVGVANYYGTLVRGLDLPARVRYAVFAGVPRHKFGSDIGDPHPSRLLRLLSILAESRIEEVASAARSHMGRLRRMLRVLSPAALQMIAERVARGEVEGGYDRQVLEAYQFLREALARDDVWESLRELDVGIVREGGRTYILVPDPATYLQASGRTSRLYAGGITLGLSVVVVDNEPVMRGLMKRVSWMAEVDWRRFEDLDLQSILREIDEDREKVRRVVKGLYRGVELVRTALLVVESPNKARTIARFFGQPSVRLLPGGGRVYEVATGDKILMIMASGGHVFDLVVRVDGRDLEAAGGEPEHAIFGVLRYRLGGNGAAAYTPVYTSIKRCLDCGYQFVDEASRCPRCGSELIRNSLSTVEDLRRVAWEADEVYVGTDPDTEGEKIGWDVALALRPYAPDIKRLEFHEVTKKAILEALSNPRSFDDNLVDAQVVRRVEDRWIGFTLSPLLWCDFWPRYCKRVLEEYGEKRPHMDRERCAKYKAYYNLSAGRVQTPTLGWVVDRTLAYRKKVWLYRVVHDSQLLFAVRSDDPEVPESVKRVLDNWVKHHKKTGIEPWLDVKAVVEKEEWTALPPPPPYTTDTMLRDANRLLGLGSAEAMRIAQDLFEWGLITYHRTDSTRVSDRGMQVAREWLETRFGGLAGQLYRPRRWGEGGAHEAIRPVRPIDVERLQLLVEEGVIELPGTLTRRHLRLYDLIFRRFMASQMREADALRVVYRLRVPELDGYTLTLERVVEIGRPGDAEGVTRGFTLVWPYVRPQPRLVEGREAWIRARVEGRQVPKAYPYTEGEIVEEMKTRGIGRPSTYAKIVETLFRRRYVIEVSREEGRGAGFVVATSRGINVYNYLTEELRSADEEEYGGRIAGILRRVPSLVSEDRTRELERQMDMVEKGDASRDDVLESVFNEISDLALLLNIEHPIKHRSRAEGNTQGNTWVSNFVACAVKSPEVSRVWGAGVG
(85) DNA topoisomerase [Desulfurococcus kamchatkensis 1221n]
3
MVSKSIRIWDLKGRILVIAEKPKAAKKIASALSPTHNAKRIGSITIYEVDSYSSSIIIASSVGHLYQLHTSLRGYPVYSYEWIPLHLTDPSKKYIREYLEVLGKLCRGVDYYVNACDYDIEGSVIGYLIIKFNGDERKAFRARFSSLTIEELRKAFNNLTRLDYEMIEAGLCRHELDWIWGINVSRALMKAVEDAVGERIILSAGRVQTPTLKYVVDKVVERNLFIPLPQYNINITVEKNGEKIRLEYTGNPVEKERDARDIVEKIRGYKYLIVSKVEKKHHILHPPPPFNLGDLQKEAARLYGFSPAETQSIAEQLYLDALISYPRTNSQKLPPTLDYRRILENISSIKSYRNLVESLISETKGVLTPVEGEKEDPAHPAIYPTGVVPGRLTEKQWAIYDLIVKRFLAVFAPPAKIVYYVVKATTPSHEYVFETKGQVIEEYGWLKYYNFHNYHAGKIPVLKEGELLNIVKATASESYTKPPKRLTKTDLLRWMESVEIGTEATRAQIIEKLFERKYLYQHQKSSGIDVSEIGFGVVEILEKFFPDLLSVELTRKFEKEMDSIRSGVKRRSEVLEEARRVLTELLGKFDRNRIEAGKQLALRLKIIQNTRKCRVSSCYREGVVNGLCSHHANAVKLVREYYGEWSRRKDITFNEYIDKLRKSKLTGKWVKEVIESELT
(848) Reverse gyrase [Desulfurococcus kamchatkensis 1221n]
6
MPGAFNPLYKGFCPVCGGDILSSEVELRGFCSRCANSGLTSILRDIASSGLGDFEEFFRRASNGLSVWGAQKIWAKRLVSGENTVLIAPTGMGKTTLLIIYSLYAARRGKRVVYITPTRTLLTQIHRRLVEAAERTGINGVNLIAYDSSMSKKKREEVLSRIEKGEYSILVATNGFLSRKSELLSRSRPDIVIADDVDSVVRSEKNVLRLLRILGYSDEVIELAKKRISLLWRLMVNKAFNNNDKYAELVKEYIEVDSLIEKTLSSTRHAQFIVASATGRMKGLMGRILKELLHVDISGVTIYGRDVTDAYMLIKPGELHGELVRIIEKLGPGGIIYIAPHHPFKNMLKEELDKAVNILADKGFRIGDATPGNVARLIKGELDILTGSASYYGSSVRGIDAPEAIRYVVFIGSPVFATSLESLLANPGMMIRVLLELVDSNDARNRVLELRRLLYTLTPGEVRLVKLALTGKILEEALQASEKLYSKYQVIKQYYRETLERTRSILDEKGIMDIGTLTLVRAGGDYYALIPDVMTYIQASGRTSRLYGSRMTHGLSIVFEYRALYNTVKGLEARLKGLNKELVFIDLASVDLDSEIKAIESSRRNNDSSPGMSYRSILVVVESPTKAKTIARFFGKPVARKLGDVTVYEIPVKIGGEIIHLNIVPTRGHIFDLTTGEEGYYGVVIADNRVTPVYEYIKKCRLCGTQFTTGDHCPRCGSRLFSDSRTIVAALRKIAGEVDEVYIATDPDIEGEKIAYDVYLAVKYYNEKVWRIELHEITLQEFLKAINNKRGINQRLVEGEIYRRVLDRLVGFKLSQELQGIYGLRFLGAGRVQTPTLGLVIDRYEEYMRNKCKKIRFKLGSPLNIIYSVFMGKNSEVIRELKTAKMLKLVRVGREIVTITPKPPYTTDELLSDAAKLNLHTGIVMSIAQQLFEAGLITYHRTDSHYVSNTGIGIAMKYIEGKKLEDYARPSHWGSPGTHEAIRPVYPYDLDDLLKAVSEGVINTVIPLTGMHLKLYDLIFKRFISSQLKPFKAVKSIYAVYFGEFKLGEIELLTNIVEEGFNVFEKTRVYKELDAVESIEVPVEEISVVDSSKSPLFTEGELVSLMKKLGLGRPSTYSKIIESIKRHGYVFVSKKRLKLIPSKRGIEVYGYLRDRYPELVSIEATRRLEESIDKIINGEVDALVYLTDIGSRLNMFHSINMVNRGDFASTSS
(709) Reverse gyrase [Desulfurococcus kamchatkensis 1221n]
6
MINLKTLLENFREFKPHGIYRHACPNCGGPIDDYRLIFKAPCSKCLNEARFKAVIKDLNGEITRFQLLKLYYDKLNKKLKKSGDLKKLMDNERMLNDFEDFFEKAIGFKMWSAQRMWARRILKGLSFSIVAPTGMGKTVFSLIATLYLVSHSRSKNREQRFYLVFPTTPLLLQAERKIKDFSRNLGINVCMDDNWGSNCLRILCIHGQQGKKEKEAALTRLKEGDFDILLTTSKFMHKYYELLKNKNFKLIVMDDVDAVLKSGKAIRRVLNIIGIEDEYIDKALTLIKARSKLAVLSSEEKSKLEKEVESLEKEISTVKQNINTILLVNTATGRPRGIYPKLFKIFMNFEAGSKPEAIRNIVDTYIESIRDIEEKMVELALKLRDGLLIFVPVDRGVEYAEKIASLLKEKGLNAEAFHSGKPAKLLDAFARGEINILVGVATYYGVMVRGIDLPERVKYIMFIGVPRHKFTPELEELSPRDLLRILSVLRDASEGERKEAIDRLIGRLSSRIRRMSPGALMMIREELAKKLRGEPVEETPFLRDAMEAYKIIKEELSKDETWHKISSLGDIGVIREGNKYYMLIPDVATYIQASGRASRLYPGGITRGLSITLVDDKRLLNGLVKRMRWIFEDFNMVSLDQVNLEELTRQIEEERRRVAEVIREGIKTTTQVEPVKTALMIVESPNKAKTIANFFGKPSIRVVKDVLQAYEVTVGNYVLSIVASAGHVYDLITDNPGESMGENLYGVLKIENRFIPVYTDIKKCSNGHQFTDEVIDNTNECPKCRINGKVSHVTRKLDIVKALRELAEEVDVVLIGTDPDAEGEKIAWDLRVLLEPYASDIKRIEFHEVTRKAILNALKNPRDFDLKLVESQIVRRIDDRWLGFSLSEKVQKYAWLKYCSEYLKNKTVKEEKDDSELHEFDCCTQNRNLSAGRVQTPVLEYIVKETEERRKPERWSYRIKIYVEDVGDFVEVTIPYIDAEELGVIKSLNKKKLLPVEIIVIGEDVEEVNPLPPFTTDALLEEASRSLRLSAVRAMEIAQNLFETGLITYHRTDSTRVSDTGISIARQYLEEKYGEKAQFYFKARMWGEGGAHEAIRPTRPIDADRLLELIKEGVLTLSVKFTKDHIRLYDLIFRRFIASQMRPAKLRKLKFKVVIKNREYYSEVYTEAVEKGYLEVYKNIELVQGIRLKPSEPGGRINGKIHEGEVIKPPMLRFHDVVRWMKENGIGRPSTYAKIIQTIIDRRYVIVSGETKALIPVERGRYVLKFLKDHYGDIVSVDTTRRLEDLMEKISRGERDYQEVLEEIYREVKNIVLENKDINDSLEKEYNERCASTT
(775) Reverse gyrase [Desulfurococcus mucosus DSM 2162]
6
MLRSVDPLYKGFCPVCGGDVSASELELYGSCKKCSRSSLTPVLRDIVAGDLDDFSGFFSKATNGLSIWGAQRIWSKRLVSGENTVLIAPTGMGKTTLLIVYSLYAARRGKRVVYIAPTRVLLTQVYRRILDAASRIGLADSMILMYDSSAGKKKREEALARIKQGDYRILVVTNSFLSRKTDLLLPVKPDVVIADDVDSIVRSEKNIVRLLRILGYTDEVVELAKKRISLMWRLMVNRAFNSEEKYAEAVKEYIEVDSELEKKLAETPRSQFIVASATGRMKGLMSRVLKELLHVDISGVTIYGRDVTDSYLLIKQGDSGRGVAELIERLGPGGLIYVAPRHPFKKELEEILGNVLKTLSSKGYRIGEATPGNVMKLVKGDLDLLVGSASYYGSSVRGIDAPEAIRYVVFIGSPVFAVKLEALLANPNMMIRALLEIANLAGDPGARGKAADLRRLVYTLSPGELRLVKLALSGKIPEETLSSSERLSSRYPEIKNYYAETLAKVKSILDERHVVEMGSITLVSVDGDYLALIPDVMTYIQASGRTSRLYGLRMTHGLSIVVEYEPLANTVRGLEARLKAINRELGFTDLRGVNLEHELELIASTRRGGGASNGLKYRSILVVVESPTKAKTIARFFGKPVARRLGDVSVYEIPVKLGDEIVHLNIMPTRGHIFDLTTDNEGYYGVLINEGGVSPVYESIKRCRLCGTQFTSGETCPRCGSRVFTDSKTVVAALRKIAGEVDEVYIATDPDIEGEKIAYDVYLAVKYYNEKIWRIELHEITVQEFLKALGSKRGINTLLVEGEVYRRVLDRLIGFKLSQELQSMHGLRFLGAGRVQTPVLGLVIERYRSFLRNRCKRVSFKLGAPLNTVFTILVDKGSELPSKLKDARVLKLVRTRREEVVVSPKPPYTTDELLADAARLGLPAGTAMMIAQQLFEAGLITYHRTDSHYVSNTGISVAVKYMEEKGFSRVARPSHWGSQGTHEAIRPVHPYDVDDLLKAIAEGLVNVVIPLTGLHLRLYDMIFKRFISSQMKPFKSVKSTFAVYYDGLKLGEVELLTRIVEDGFNLFEKVKVHSELDDVESLDVSVEDVVIADSSRIPLYTEGELVSLMKQLGLGRPSTYSKIIENVRRHGYVIASKKRLKLIPTKRGMEVYEYLVSRYPDLVSVETTRRLEESIDRIGKGEVDARTLLTEVCSRLNIWGKPVEGATSISS
(925) DNA topoisomerase [Desulfurococcus mucosus DSM 2162]
3
MVSGVEPWMSRGVRIWDLKGRVLVIAEKPKAARKIAEALSPGYVTRRIGSIPVYEINAYGSMILVASSVGHLYELNTGVKGYPVYSYEWVPSHLVNPGKRHAREYLEVLKKLCRGVDYYVNACDYDIEGSVIGYLIIKFNGDEEKALRAKFSSLTREELRQAFNNLAKLDYEMIEAGLCRHELDWLWGINVSRALMKAVEDATGRRIVLSAGRVQTPTLKYVVEKTVERNLFIPLPQYRVTVTAERNGEEVVLEYAGNPVEKHGEARSIVERVRRQGYLIVEEVEGKTYVLKPPPPFNLGDLQEEAARIYGFSPAKTQAIAEQLYLDALISYPRTNSQKLPPTLNYRGILDNLASIGKYSGLVASLLSETRGVLKPVEGEKEDPAHPAIYPTGMKPGGLTDEQWAVYDLIVRRFLAVFAQPARLTHYTVKAVTPSRDAVFKASWQRVEEQGWMKYYGFHTYKSSRAPGLVKGDKLGVVKVSMRESYTKPPKRLSKIDVLRWMESVEIGTEATRAQIIEKLFERKYLFLESKGIGVSDLGFGVVEVVERFFPDLLSIELTRRFEKEMDAIRRGLRSRGQVLEEAKRILTAMLGEFDENRVEAGRQLAVRLGVAEPSRGKCRISSCKREAVEEGLCRHHASAARLIHEYYVEWSRRKEIGFDEYVEKLRKSRNTGKWIKEVIEAGVVKAPRFP
(1012) Reverse gyrase [Desulfurococcus mucosus DSM 2162]
6
MPDLPGSPSLPDGFKTHGVYRHACPNCGGPISDYRLIFKAPCEKCLRDEEFRGIVELAGKRGGIDRFQLLRLYAESSREGALRELVKREEMLRDFEAFFEKATGFKMWSAQKTWARRVLKGLSFSIIAPTGMGKTVFSLVTALYITQRARREGDPRGWRSYLVFPTTPLLLQAERKLRAFAENLGVSICSNDNWDNGDCIRILCIHGHLGKRDRETAMNRLKEGSFDILLTTSAFIHRNYELLKGKGFRLIVMDDVDAVLKSGRAVRRLLGIIGVEEEHIEKALTLVKARSRLVAASGEERARLEEEIRGLENEVSSVRSRINTMLLVNSATGRPRGMYPKLFKVFMGFEAGSKPEAIRNIVDSYVEPQGGIEEELVKLVLTLRDGVLVFVPVDKGVEYAERIVELLREKGLRAEAFHSKTSIELLDAFAKGDVNVLVGVATYYGVMVRGIDLPERVKYVVFAGVPRHRFSSMLEALSPTDILRVLAVLRDIAEGEKRDLIERLLGRISSRLRRMSPGAVLRLREELARKIRGESVEETPLLSTLFEAYKVIAEEFSKEETWQRISGLGDVGILKENDKYYMLIPDVATYIQASGRASRLYPGGITKGLSIVVVDDKRLLNGLVRRMRWIFEDFTMTPLSQVNLEELMKQIEEERRRVSEVIKGGTAAGTWVEPVKTALMVVESPNKARTIAGFFGKPSVRIVGNILQVYEVTIGSYVLSITASAGHVYDLVTDKSLPEAEGAEALYGVLRVDGRFIPVYTDIKKCSNGHQFTEELGGNTVECPRCKMDNKQSHVIRKLDVIKALRELAEEVDVVFIGTDPDAEGEKIAWDLRVLLEPYANEVRRIEFHEVTRKAILNALREPRDFDIRLVESQIVRRIDDRWLGFSLSEKVQKYAWMDYCLRYLFHKRGLVEKSTCCRPNGNMSAGRVQTPVLGYIIEETDARSRPERYVYRMKIYIERIGDLVEVSIPYIDAKNAGIVDTVKKRPHPVEVEVVSEEEVQLNPPPPFTTDSLLEEASRTLGLPATRTMEIAQDLFETGLITYHRTDSTRVSDTGVKIARQYLEDKYGEKAPHYFKPRTWGEGGAHEAIRPTRPIDSDRLVELVKEGVLSLPLRLTRDHVRLYDLVFRRFIASQMEAAKLRKLVLRVYIGDRSYETEIYTEAVWKGYLEVYENVRLLGRELGLKPGERVEAEIHDGNRVTPPRLRSHDVIRWMKEQGIGRPSTYAKIVQTLIDRGYVRVTGKVKALIPTERGRSVFNFLGKYYGNVVSVDTTRRLEELMEDISKNTVEYQSALEGIYREVTTAVIGNHRVNELLEKMYREKCSEEK
(746) Reverse gyrase [Staphylothermus marinus F1]
6
MEKILDPIYKNLCPTCRGDVFANSLWDFGVCGKCSDEPGNSINAVTLYHAFKEDLEDFTHFFGKATGDLNPWGAQLTWAKRLLNGENTVIVAPTGMGKTTLLIVYSVYVAKNYNKKVLFLAPTRALAKQIYTRIIEAVKNVCGTCINVLFYDSGLSKKRREEVLLKIKNNEYDILVLTNHFLIRHYDLLDPNHIGLIVIDDVDSLMRSSKNILRLMKLLGFREELIEKAKKRNSIIWKLMLSKSLNKEEDYRKYIEELIEIEAEIDELLRNSSRKQVVIASATGRMKGIYAKVMRDLLRIDVSGITIYGRNITDTYLLISDHVRDTDKILGFIETLGPGALIFISPRHPLKKNLIELVGLLRRKLEEKGYRVAEANPSTIKKFVRGEYDFLIGSSSYYGVSVRGIDAPETIKYVLFIGTPLFTVELGSFLASPNMLIRVSLMLSEVLGDQRFRGVASTIRKLVFPLNNGEIKLLSMLLKNKITINDLGKDSRIVKVYEQILDFYNDIRKSLEELLSKKKVVDMNTITFYHDNNKFYALIPDVMTYIQASGRCSRLYLGKMTHGLSLVVEYDFLSNLVNGLSLKMNMFSRGFGFKDINDIDLYEEKKLLEKTRKELKGLVLTYRNILVIVESPTKAKTIARFFGKPVRRKIGSISVYEIPFVKDSEVIHLNIVATRGHLFDLTTDPSIPNHGVLIENNRISPVYTSIKRCRVCGYQFTYGDRCPRCGSTSFTDSYEVVNVLRKLAQEADEVYIATDPDIEGEKIAYDVYLTIKGFVDRVWRIELHEITLNEFLNALENKRNINLKLVEAEIYRRVLDRVIGFSLSQELWRKYSKNWLGAGRVQTPVLGWIIDHYNKYVSNKCRKIIYITEREGLKFSICIDLKDRDLYEKMRSVEYVTLVLKNSRIETFNPPPPYTTDELLYDASRIGIPSTLTMKIAQELFESGLITYHRTSYHYVSSAGISVASKYLENKNLSKHFHPSHWGNKGAHEAIRPVHPLDREDLEKAVVEGIITPTIPLTWLHYRIYDLIFKRFISSQMNPYKALISEYDVVINNEIVKTLVLPIEVVEEGFNIVMRPKTYGFLKGHDRIDISIKDIKTMITSTKPLCSEGGLVKLMREHGLGRPSTYSKIISNIVRHGYVIRSKKRGFLIPTKTGIEVYDYLSNSFPELVSIDTTRDMEMRIDLIAKGEMRAADEISRVIDRIRRYKLPLSIREVVAEASA
(926) Reverse gyrase [Staphylothermus marinus F1]
6
MVELKHIHGYYRYSCPNCGGEDSDLRLIHKAPCDKCIEEELFYRIRENIGEKSYKEILETYYRMLLKNNKLKKRFEFLYKFEEKLEKFEKFFSEATGGYKFWSAQRTWARRLLKRRSFSIIAPTGMGKTMFALISSLYLSKKQIMIQKNRISRKKIYLVFPTTPLLLQAEKKLRKLAEQEKIPVCQEEDSDQTCLNIISIHGRVPKKKREKLLEEIRSGNFDILLSTNMFMHKNYELLLDKKYELIVMDDVDAILRSGKAIRILFYILGLTDQEINEAIEYLKLRQRLALKLSEEERRELEEKLETLEKRIEKYKRKIDTVVIVSSATGKPRGIYPRLFRILLNFEAGSRAEAIRNIVDTYTYSKESLEQTIIRLAKKLGDGGLIFVPIDKGVEYAETIAELLKKHGINAEAFHAKKAVKLLEEFASGNIDILVGVATYYGVMVRGLDLPDRVKYAIFTGVPRHKFSTRLESPSPIDVLRIFTILRDVLEGEEKRKAEILIGRISLRLRRLSQGALMKLKEDFMKKLQGEEVEEYPLLSLLMEALSMARELLSKPEIWEKLKQKGDVALVQEDGKSYILIPDVATYIQASGRTSRLYPGGITKGLSIVIVDDQRLLNGLIKRMRWLFEEFDMKRLDEVDLDKLMKEINEERRKVKMILEGRIEVEKTLELTKSALLIVESPNKARTIANFFGKPSIRILENGMPVYDVTTGDYVLSIIASIGHVYDLVVDDGLYNYGVRLVGDKFIPVYTDIKRCNKCGYQFTAETNTCPKCGSRDISRKLDIVETLRELANEVDVVFIGTDPDTEGEKIGWDIKVLLEPYAREIKRVEFHEITRKAILNAIRNPRDFDMKLVEAQIVRRVEDRWLGFALSKKVQKYFWPIYCFKVLHPLLNKYVREGKRITDKMPFCCIENRNLSAGRVQTPVLGYIIRRFKEHNDESKFRYLLTIKINDSRLRVDIDRSVLEIIGITSHRNLIGYRVEVREEDRKEEIINPPPPFTTDTLLEEASIRLGLSTTRTMEIAQELFELGLITYHRTDSTRISDAGINVARQYLEEKLGEKAKEVFKPRTWGVGGAHEAIRPTRPIDADRLAELIREGALILARPLTRLHYMVYKLIFNRFIASQMIPAKIVKQVLKIRMNGYEKKVERVIGIIEKGFLEFYQTVNVEEEVKPGTYPVVDVEVLKPPLARYHDVIKWMKTNGIGRPSTYAKIIQTLIDRKYVNVSKRVKALIPTKRGTMVYEEFLDKYYKDVVSVEVTRELEKKMKEVEEGIRDYQEVLHEIFNELKTKIIDNPVVNKELEQKWSKHCGQIESSK
(636) DNA topoisomerase 1 [Staphylothermus marinus F1]
3
MGDKAKKSIIDYILSYSEKQKKKPVKTKEKTSSKKAIEKTEIQITHNIWDLIGKIVVIAEKPKAANKIALALSRNPIRKSMYGIPYYLIKNRHSSIIVASAAGHLYGLHTDQYGYPVFKYEWKPLYQIDPKAKHTEKFIMVLSKLCSNADYYVNACDYDIEGSVIGYLIIYFHGDLEKSLRAKFSSLTIEELRESFRKLTSLDWEMIEAGLCRHELDWIWGINISRALMSSVKIASGKRVILSAGRVQTPTLRYVVEKDIERRLFIPLPQYSLSINIFKNNYEIHVEYKGKSVETKKNAKEIIDEIKRTGYLIVKKYEEKIYTLNPPPAFNLGDLQEEAARIYGFSPYKTQSIAEKLYLDALISYPRTNSQKLPPTLNYKAIMNKLSRINNYKELVSNLLVETKGVLKPVQGSKDDPAHPAIYPTGVKPKDLGKDEWKIYDLIVRRFLAAFASKARISHRIVYLEYPKDPSMVFQASGQKILDLGWLRYYPFSKPEERFLPKFQYGEKVKIVKASIRKTYTKPPEKINKIKILRWMENVGIGTEATRARIIEILFSRYYLRSVGGRVEATDLGLGIIEVLMEYFPEITSVSLTRHFEEEMEKIRLGVKRREEVVKDAKNTLIKLIVSFDKKKYQIGKTLSYRLGYITPINKCILCNREAYKNNLCKYHYRALNTVIKTYDEWKRREGVDWNKYLSSIKKLKSTGKWIVEVIQNFEKIKYSPSE
Family distribution
Taxonomy tree
Desulfurococcaceae