Home | TopoIBase

Name	Family	Sequence
(WP_012259747.1) MULTISPECIES: type I DNA topoisomerase [Chloroflexus aurantiacus J-10-fl]	2	MGEKVVIVESPAKARTIQKYLGKGYKVASSMGHVRDLPKSGLAIDIEHDFAPSYEIVKPKVVSELSQALRNAEAVYLATDPDREGEAIAWHITQAVKLPKKTPVYRVVFQEITRNAVQQALQQPRQINQNLVEAQQARRVLDRLVGYQLSPLLWDKVKRGLSAGRVQSVAVRLIVEREREIEQFQPQEYWTIEADLLKDAGVAPRDLFRAVLIERDGKKLEKFSIENREQAEAIVADLQGAAYTVVRVTRRDKRRSPAPPFTTSTLQQEAARKLGFSAKKTMTLAQRLYEGVDIGGEDGMVGLITYMRTDSVQVAAEAQTEARDVIGKRFGKEYLPDQPPVYKTKAKGAQEAHEAIRPTSSARLPEQLSGKLENDLWRLYDLIWKRFIASQMAPAVFDSTTVDIAATPVVAGAPAYLFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPPLAEGEALQLVELLPIQHFTEPPPRYTEASLVKELERLGIGRPSTYASILSTIQEREYVEMVDKKLIPTTLGRVVTDLLVEHFGNIVDYDFTSALEQQLDDIAEGSKKWVPVLREFYGPFRSTLEQAQRQMRNVKREEIVTDLDCPKCGQGKLVIRFGRNGEFLACSRYNREGDGESCDFTSDFHRDEQGQIVIDKASAPETSDVLCNVCGRPMVIKKSRFGPFLGCSGYPECNNTRRIGRDGKPVPLPEPTGVQCPKCGEGELLRRRGKFGRPFYGCSRYPKCDYITNTLDEAQAGEAPAEPAKNEPALPSPSRSSKRTRKSA
(WP_012616618.1) type I DNA topoisomerase [Chloroflexus aggregans DSM 9485]	2	MGEKVVIVESPAKARTIQKYLGKGYKVTSSMGHVRDLPKNGLAIDIEHDFAPSYEIVKPKVVSELNQAVRNADAIYLATDPDREGEAIAWHITQAVKTPKKTPIYRVVFQEITRNAVQQALQQPRQINQNLVDAQQARRVLDRLVGYQLSPLLWDKVKRGLSAGRVQSVAVRLIVEREREIENFKPQEYWTIEADLLKEAGIAPRDLFRATLIERDGKKLEKFSIERREQAEAIVADLQGAAYTVLKVTRRDKRRSPPPPFTTSTLQQEAARKLGFSAKKTMMLAQRLYEGVDIGGEEGMVGLITYMRTDSVQVAAEAQAEAREVIDRRFGREYLPDQPPVYKIKAKGAQEAHEAIRPTSSARTPEQLSERLERDLWRLYDLIWKRFIASQMAPAIFDSTTVDIAAQPSVAGAPPYLFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPPLVEGENLQLVELLPVQHFTEPPPRYTEASLVKELERLGIGRPSTYATILSTIQEREYVEMVDKKLIPTMLGRIVTDLLVEHFGNIVDYDFTSSLEQQLDDIAEGSKQWVPVLREFYGPFRSTLETAQRQMRNVKREEIITDLDCPKCGKGKLVIKFGRNGEFLACSRYNREGEGDSCDFTGDFHRDENGNIVLDQASAPETSDVLCNVCGRPMVIKKSRFGPFLGCSGYPECTNTRRIGRDGKPVPLPEPTGVTCPKCGEGELLRRRGKFGRPFYGCSRYPKCDYITNSLDEAQAGVAVEAAPALPPTVEKPAAPARKSSGKTRKSA
(WP_012120209.1) type I DNA topoisomerase [Roseiflexus castenholzii DSM 13941]	2	MGEKLVIVESPAKARTIQKYLGSGYRVEASMGHVRDLPKSNLGVDLEANFAPVYEISPGKEKIIAALRKSIRQADAVYLATDPDREGEAIAWHITEAAKIPRDKPVYRVVFTEITPGAVRSAMASPRDIDRRLVDAQQARRVLDRLVGYKLSPLLWEKVRRGLSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQNASDSQRDAFRAMLIERSGKKLEKFDIGASDQAQAIIADLEGAAYIVRKVTRRDKRRSPAPPFTTSTLQQEAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARRVIRERFGEAYLPAKPPVYKTKAKGAQEAHEAIRPTLSRRTPEQVQPYLTSDQYRLYDLIWKRFVASQMEAAVFDSTVVDIGAGRDIGGRGAGSDPYTFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPLLEEGEALNLLQLLPVQHFTEPPPRFTEASLVKELERLGIGRPSTYAPTISTIIEREYVELADKKLVPTTLGRVVTDLLVEHFPSIVDYGFTSEMEQQLDDIAEGEKEWAPVLRAFYRPFEQKLAEAQRSMRNVKREEILTDLTCPRCNQGQLAVKFGRNGEFLACNRYPECDFTSDFHRDSDGRIVLDAPASPETSDVLCDVCGRPMILKKSRFGPFLGCSGYPECKNTRRLDKQGKPAPLPKATGVTCPKCGQGELLERRGKFGRPFFGCNRYPKCDYLVNSLDEVAHYTPDANEASKPQAEEPTATDAKATPARKRVKTDANGAAAAGKRVKTDANGAVAGEPMKTKASANGKRAKTGTNGAAAAPPKKRGTER
(WP_012874441.1) type I DNA topoisomerase [Thermobaculum terrenum ATCC BAA-798]	2	MANKLVIVESPTKAKTISRYLGRGYSIKASMGHVRDLPKSKLGVDTEHDFQPQYLIPRDKSKTVKELKESVASAREVYLATDPDREGEAIAWHLIQATGMDTSKARRVVFHEITPDAVRNAMANPREIDMRLVDAQQARRVLDRLVGYNISPLLWKKVKRGLSAGRVQSVALRLVVDREREIQSFVPVEYWTISADLAKQPAKGRKPSRKDQFRALLVRINDEKVEISNEEQARAIIEALEGATYKVLEVKQREIQRKPAPPFITSTMQQEASRKLNFNARRTMSVAQSLYEGVSLGDEGDVGLITYMRTDSTNVATVAQEEARQVIAQLFGDKYLPEKPPVYTKKAKNAQEAHEAIRPTSVKRHPDAIKQYLTSDQYKLYKLIWQRFIASQMANAIIDGTTVDIAAEPRSGGAPYIFRATGSVIKFDGFLVVYQEGKDDDQEEELGSKALPPMTEGEVLNLIQLLPEQHFTQPPPRYTEASLVKALEEQGIGRPSTYAIILSTLQERYYVVKDGKALVPTELGMLVNDLLVEHFPDIVDVNFTSQMEEELDDIASGERAWVPVIKEFYGPFERKVRIAEEEMQKVDIQDEPAGENCPNCGRPMVFKMGRYGKFIACSGFPECRTTKAIVNRTGVQCPACRQGELVERRSRKGRRSIFYACDRYPDCEFTISAKPLPQPCPACGGLQVEDGKNGQKCIRCDGQGNILQKSA
(WP_013560005.1) type I DNA topoisomerase [Anaerolinea thermophila UNI-1]	2	MVIEAYCVKCKTKREIQDPVAEFTATGSPVTRGVCPVCGTKIFRLGKTPEHEKLTPPESVRKEKTKTRSGKLVIVESPAKAKTVGRFLGKGFTVKASVGHVRDLLRSELSVDIEHDFQPKYRVPNEKRAVVKELKALAQEAEEIYLATDPDREGEAIAWHLMQAAEIDPRLSKRVVFHEITKPAIDEAFSHPREINMALVDAQQARRVLDRLVGYNLSPLLWEKVRSRLSAGRVQSVALRLIVEREREIQAFIPVEYWSIEAELQPEGVSSTFIAKLSKIDEQDPELPNQEVVSRYLADLEQALFIISKIRRSERRRKPAAPFITSTLQQEASRRLGFTARRTMAIAQQLYEGLDVGEGGTTGLITYMRTDSTNISEVALREVREFIKETYGGSYLPESPLQYKTRAVSAQEAHEAIRPTSVARTPEKVKPYLSPEQYKLYQLVWQRFVACQMESAVYDTLSVEVDAKGEEHQYLFRASGSTLKFPGFLVVYEESRDEDQVSEDEGTETRIPAHIQEGQKQELVRLIPEQHFTQPPPRYTEATLVQVLEENGIGRPSTYAPILSTIQERGYVVRDGKRLVPTETGILVNDLIVAHFPDIVDTGFTAKMEEDLDRIAAGNEKWVNVIRQFYQSFSPQVERARMLMPESKSEPEKVGRQCPQCGHDLIVRWGRFGKFISCSNFPNCRYTEPWLEKIGVRCPKDGGEIVERRTRKGRVFYGCENYPNCDFTSWKRPIPASCPQCSGMLVIANKREVQCLSCQEMFLMEQFVENVEVNQP
(WP_232528581.1) type I DNA topoisomerase [Pelolinea submarina]	2	MEAYCMKCKEKREIQNPTAGFNSRGTPVTTGTCAVCGTKLYRMGRTDAHEGLIPPEPVPGAKKTKSGKTATAKRKGKMVIVESPAKARTVGNFLGKDYIVKASVGHVRDLLRSQLSVDVENNFEPKYRVPNEKRPIVKELKADAQKVEEIYLATDPDREGEAIAWHLMEAAELDEGRVKRVVFHEITKPAIAEAFSNPREIDINLVDAQQARRILDRLVGYNLTPLLWEKVRGRLSAGRVQSVTLKLIIEREREIEAFVPEEYWTIDGEFKPENQKDTFTARLVKIDDQDPQLPMQGVVDGLLADLKASHYTVSKIKRGTRRRKPFAPFTTSTMQQQASRQLGFTAKRTMRIAQQLYEGIDIGEGGETGLITYMRTDSTNISPLAIKEVRDYIKEVHGPEFVPETENKHQTKAMKAQEAHEAVRPTSVMRVPEKLKPFLKPEQFKLYQLIWRRFVASQMEAAVYETLSIEINGDGKDHQYLFRASGSQIQFPGFLVLYEEAKDDDSNGDENKELKIPEDLLEGQLILLVKLNPEQHFTQPPPRFTEASLVQTLEELGIGRPSTYAPIISTIQARGYVERDGKRLIPTDTGFTVNDLLVEYFPDVLGVNFTAHMEEDLDEIASGEREWRKVIADFYQSFEPQLKRAQDEMPETKMEPEKIGKACPQCGNDLVIKWGRFGKFISCSDYPNCKYTEPYLEKIGVLCPKDGGEIVIRKTRKGRIFYGCENYPNCDFTSWKQPISTPCPSCSGLLTFKNKNEYQCMNCEETFLISSINVEESESA
(WP_010936459.1) type I DNA topoisomerase [Dehalococcoides mccartyi 195]	2	MKEKLVIVESPAKARTISKMLGKDFNIMATMGHIRDLPKSTLGVDVENSFTPKYVSLKAKAKVIKELKDAVKNSKAIYLATDPDREGEAIAWHISEVTKANLAKPKRVVFHEITKEAIDKAFKNTRELDMDLVNAQQARRVLDRLVGYKLSPLLWRKVQRGLSAGRVQSVSLKIIVDREREIEKFVSAEYWNIEALLNKKVKSAAFKASLAGYVTKGKLEIHNESEAEQIKKELEVSDYQVLKIKKKSNLRQSPAPFITSTLQQEAWRKLHFSAKQTMVIAQQLYEGLNIEGEGEVGLITYMRTDSTNVARTAVAETRDYISEKYGPAYLPKQARVFSSKVKGAQEAHEAIRPTRIIRTPDLIKKSLSTEQFKLYQLIWQRMMASQMSPAVFDNTTIDIEAKHQPSKTRYLLRTTSSVNTFPGFTIVYIEGKDEDEEAAQSSLPPMEEGEELKLKSLEASQHFTQPPPRYTEATLIKALEQYGIGRPSTYAPTISTIQEREYITKLKGSLKPSELGMLVNDLLVEYFPDIIGIDFTAAMETELDKIATEKLDWVPIIRRFYEPFIKEIEAASEKIEKIKPPEEELDELCPECNAKLVVKRGRFGKFIACSRYTKEEGGCRYTRSYQIKTGAKCPECNSDIVEKYSKKGKIFYGCAGYPNCKFVSFYKPLSKPCPECGALMIKSGKNWAKCTKCGKRKKLEDES
(WP_102330518.1) type I DNA topoisomerase [Dehalogenimonas etheniformans]	2	MATDKKLVIVESPAKARTLAKFLGSGYTLKASMGHVRDLPKSKLGVDVDHDFAPQYLNMRDKLTVLKELKEAAKKAGTVYLATDPDREGEAIAWHLKEATCTPSVPCRRVTFHEITKEAIAAAFKSPRDVNMNLVNAQQARRILDRLVGYKLSPLLWQKVRRGLSAGRVQSVALRIIVDREREILGFKADEYWTIEVELSKLVPSTPKSFKALLIGSGDKKKIAIGNEAAAGDIVADLKPAEYSVAKVTSKDSPRQPAPPFITSTLQQEAYRKLRFSAKQTMAVAQQLYEGLSVGAEGSVGLITYMRTDSTHVASSAIAETRDFIAEKFGSNFLPKSPRLFARQVKGAQEAHEAIRPTSTRREPAAIREFLEPNQFKLYQLIWQRMVASQMAAAVFENVTIDIDARKTPSKTRYTLRAQNSKNTFPGFMALYTEGRDEEEEAKTPPLPSLSENEMLKLLDPKAGIKPEQHFTQPPPRFTEATLVKTLEQFGIGRPSTYAPILGVVQEREYVTKDKGAFKPTELGVAVSDLLVQQFPEVIDTGFTAQMEDKLDKVADEGLDWVKVVRDFYAPFEKDLATAEEQLERVPMPIEISDECCPQCSKEKLLIKVGRFGKYMECPACGFRQSFRIRTGVMCPNCPEKGEIIGRYTKKGKLFYGCSAFPKHSFAMNAKPLPEPCPKCGGIMGELKPGQKSCQNPECADYKGKRFFRRSTTSSAASSSKSTTAKAKIKTSAKRAKPTRSKPTAKEK
(WP_076003849.1) type I DNA topoisomerase [Dehalogenimonas formicexedens]	2	MATDKKLVIVESPAKARTLAKFLGSGYTLKASMGHVRDLPKSKLGVDVDHDFNPQYLNMRDKLAILKELKEAAKKAGAVYLATDPDREGEAIAWHLKEAACTPSVPCRRVTFHEITREAIAAAFKSPREVNMNLVNAQQARRILDRLVGYKLSPLLWQKVRRGLSAGRVQSVALRIIVDREREILGFKADEYWTIEAELSKLVPSTPKSFKAILIGSGDKKKISIGTGTAASDIVADLKPAEYSVARVTSKDSPRQPAPPFITSSLQQEAYRKLRFSARQTMAVAQQLYEGLPVGAEGSVGLITYMRTDSTHVAASAIAETRDFIAEKFGSGFLPKTARLFARQVKGAQEAHEAIRPTSTRREPAAIKEYLEPNQFKLYQLIWQRMVASQMAAAVFENVTIDIDARKTPSKTRYTLRAQSSRNTFPGFMALYTEGRDEEEEAKTPPLPPLSEGELLKLLDPKASVSPEQHFTQPPPRFTEATLVKTLEQFGIGRPSTYAPILGVVQEREYVTKEKGAFKPTELGMAVSDLLVQQFPEVIDTGFTAQMEDRLDKVADEGLDWVKVVRDFYVPFEKDLSTAEEQLERVPMPVEVSEDCCPQCAKEKLLIKIGRFGKYMECPACGFRQSFRIRTGVMCPNCPEKGEIIGRYTKKGKLFYGCSAFPKHSFAMNARPLPEPCPKCGGLMGELKPGQKSCQNPECADYKGKRFLRRSKTASTSPRSRSVSTGSKTAAAVKRTKAGQNKSRPEEK
(WP_129893217.1) type I DNA topoisomerase [Ktedonosporobacter rubrisoli]	2	MAKKLVIVESPAKAKTIEKFLGRDFVVLASMGHIIDLPKKGLGVNTRKNFVPQYEVIEKKDRLIDELKKASLRADEVYLAPDPDREGEFIAWSLKNILGLQNPHRAVFHEITKRAVQEAIKKPREIDEDLFNAQQARRVLDRLVGYKISPLLWRRIQSGTSAGRVQSVALRLICDREAEIRAFVPEEYWSITATLSKQKQKERFEATLITRLKDMAMLNEEANEGEEQNGAEGQNTAGAKKEKGRIKVGSKEEADAILADLQGATYSVLKYEEREQRRQPYLPYTTSTMQQDASVRLYFKPKKTMSLAQQLYEGIELGQRGHQGLITYMRTDSTRISDEAQAAVKTYIAGEHGQNYVGPGRVGKAKATTQDAHEAIRPTDVNLTPQVVKSYLTPDQFKLYNLIWRRFVASFMAAAIFDTVRVDIVARQYVFRATGSNLKFPGFYAVWPREEDEKILPVMQVKEELDFHGLKPEQHFTQPPPRFTEASLIKELEEQGIGRPSTYVPIISTIQDRGYVDQEQRRFLPTWLGETVNDVMNKHFPEIVDTRFTAEMERKLDEVEEGRYSWTEFLHSFYGDFKESMKKAEAEMDRVQKPLEELDEVCPECGRNLVIRTGRFGRFISCSGFPECSYRRSFVNKTGALCPLCNGDLVERKTRQKKRIFYGCANYPTCNFAIWERPVPDLCPNCGGLMVVPKAGQAPVCYAEYVAGQRDAEEKPVQENVKKTTRTSRKKASTTESTAKAAKPSRRRTTAKKQEEADTPAEATNGTAKRATTRSSATRTRKSASSTGKATTRSRSTASKESSSGKTRTRAAK
(WP_014431876.1) MULTISPECIES: type I DNA topoisomerase [Caldilinea aerophila DSM 14535 = NBRC 104270]	12	MGKKLVIVESPTKAKTIGKFLPKEYLVKASMGHVRDLPASAAEIPEKEKNKPWARLGVNVEADFEPLYVIPESKRKVVAELKAALKDAEELILATDEDREGESIGWHLREVLKPKQPVRRMVFHEITREAIEQALRETRDLDLNLVHAQETRRILDRLVGYTLSPLLWRKIAPRLSAGRVQSVAVRLLVQRERERRAFVPGQYWDLRALLNKRPDQPGHRFEATLVSVGGQRIASGRDFDERTGQIAAGKDVLLLNQQEAEALRARLLDGEWTVVEVEEKDATRAPYAPFTTSTLQQEANRKLGMSAKETMRIAQNLYENGYITYMRTDSVHLSDEAIHAARRRIREMYGEEYLSPSPRRYQTKTANAQEAHEAIRPAGDQMSPPDSLPLEGREKALYELIWKRTIASQMANARLKLRTVMIAVDNALFRASGRTILFPGFFRAYVEGSDDPDAALESQEQPLPALSVGEIVDCRELEAIGHETQPPPRYTEATLVKALEAEGIGRPSTYATIIDTILQRGYAFKQRKELVPTFTAFAVTALLEKHFQELVDLKFTANMEQRLDDIATGAADHLAYLREFYLGEGGLEHQVKSREAAIDPREASTVALDDLHAEVRIGQYGPFIVREEDGERLTAGLPPTLPPADLTDHLVEELLNKKVEGPQMLGVDPESGLPVLLKTGPYGPYVQLGEDDPEGKTKPKRASLLKGMNPEELTVETALALLSLPRTLGEHPETGKPVQAGVGRFGPYVVHDGVYVNLRPPDSVLDIELDRALELLAAKASGGKGRSTGKSVIKELGEHPEGGAVQVLDGRYGPYVSWKKINVTVPKDIQPADVTLEQALAWIAEKRAKPASTRKRATKSTKTAASKPLE
(WP_195171124.1) type I DNA topoisomerase [Phototrophicus methaneseepsis]	1	MKLVIVESPAKAKKIAHFLGDGWQVEACRGHVRDLPETELGVDIDADFRPQYQVLAGKGNLVKKLVKAIREADAVYLATDPDREGEAIAWHLLALAGNLKDKPVYRSAFNAITESAVKAALAEPRSLDQSLVEAQSVRRIVDRLVGYLVSPLACKALNGRLSAGRVQSVALRLVVEREREIEAFKVESFWTLKAILEANDSRFEAKLHRLKDADVKFNAREQAEKLVGLLQSASFRVNKAGQTLKLRNPLPPFTTSSLQQAAAKGLGLSPEKTMQLAQTLYEQGRITYHRTDGVSVAVEAQQAAGLLILKDYGTEYLPETPPVYKTRTANAQEAHEGIRPTDVSHLPEANDGDAAKLYALIWKRFVASQMAPARYTVTAALIHAGKAVDKPFPLIFKAQGRVLDFDGFLRVYEEPDDVDQSEAEDSGAVPALKDGQTLHLVELPIDEGQTRPPARFSEAALVQKLEAVGVGRPSTFASMLKVIKDKKYVALKQKRLQPTETGTQLNDFVVERFPQVFDVAYTARLETALDRVANDDLSRSDLLSAFWRGFQPQLKAATEYTLTQMKARPQAKPIGETCPECDADLVERQGSNGVFVGCSAYPKCSYTRNVEHKPLVLHPVED
(WP_195171680.1) type I DNA topoisomerase [Phototrophicus methaneseepsis]	1	MKLVIVESPAKAKKIAGYLGDGWQIEACRGHVRDLPESQLGVDVEQDFRPQYVMLPGKGNLVERLVKLIRKADEVYLATDPDREGEAIAWHLLQLAGDLKNKPVYRAAFHAITEEAVQAALADPRPLDAALVEAQSARRVVDRLVGYLVSPLACKTLDDRLSAGRVQSVALRLVVEREQQIAAFQSDTTWGVEAILEASGTRFEAKLHRLKDADIPFKDAAQAEKLLTLLKRASFWVSKTGQTTKHRNPLPPFTTSTLQQVASKGLGLSPEKTMSLAQMLYEQGRITYHRTDSVAVAQEAQTVAREVISREYGERYLPTASPIYKAKTANAQEAHEAIRPTDISQMPAVHPEGDVPSSNAAKLYDLIWRRFIASQMTPADYTVTAILIRVGRSQDKPYPLSFKANGRELTFDGFLRVYEEPDDVDAGVDAEAVEIGSVPSLRDGQILKRVDVAVNESQTRPPSRYSEAALVQALEKYGVGRPSTFASMVAVIKHKKYVTVKQKHLVPTKNGMKLCAFLIERFPQVFDMDYTARLEAALDQVASGQLSRSRLLNTFWRGFQPQLKSATEYALTQVKSRPKAKLIGETCPDCGGDLVERQGANGVFVGCTNYPSCTYTRSTGHQPLTLHPAEGA
(WP_195168925.1) type I DNA topoisomerase [Phototrophicus methaneseepsis]	2	MSDPMRGYCMKCKEKRDMIEPQATYTKSGVPATTGKCAVCGTKIFVMGETPAHANVPKPEVIERPKKTKKKAKKGAKKAKSTRSKKVGKLVIVESPAKARSIGSYLGDGYTVMASKGHVRDLLVTQLSVDVENDFEPKYRVPNDKRQTVKQIKQAVEGAEEVYLATDPDREGEAIAWHLAEAIGMDDTQAQRVTFNEITRDAVRESFDSARNIDMDLVNAQQARRVLDRLVGYNITELLWDKVRNRLSAGRVQSIALRLVVDREEEIEAFNPEEYWTIEAELAKQSTNGHQPESFVARLAKINGDDVNLTSDSEVQPHVDILEKSQYLITDVKIGTRRRKPSAPFTTSTLQQEASRRLGFNARRTMRAAQSLYEGVELDNGEIVGLITYMRTDSLNISAQAQQEARNYIVENFGKEYAPEKVRNYKTKAKGAQEAHEAIRPTSVLRAPLEIKKALQGAGRDLFKLYQLIWERFVSSQMSNAVYDTVRAEISAGLNTNDMPYLFRASGSRIRFKGFLAVYEESRDEDAPQITDDRMLPELLADELLNLVQLLPQQHFTQPPPRYTEASLVRTLEELGIGRPSTYAPTVAVIQDRDYVTKEDKRLVPTDTGKVVSDLLVKFFAEEMDYQFTARLEDQLDEISQGGTEWQPFMHDFYEPFSVRLQNARSNMPQMKQEELVGRKCPTCGTGDLVIKYGRWGKFIGCSNYPECRHTEQYLEYIGVPCPVCGEEHGGEVVELKSRRGRTFYGCSRYPDCDYRSWNRPGSDQEQEATEDKEAVHEEAS
(WP_158067733.1) MULTISPECIES: type I DNA topoisomerase [Tepidiforma bonchosmolovskayae]	1	MATATATRRRRKTDAEAPALEGGSAAAPARGRKGPRYLVVVESPTKARTLQSILGSDYEVIASLGHVRDLPTYGYGVENVEQLDFRPKYVVVKDRNARVDKAEVIREIAEAAKRAERVFLSTDPDREGEAIAWHIKEAAGIPDEKVTRVVFHEITRPAIEAAFAEALGQAPASAEHGRREPGKLDMHLVDAQQARRVLDRLIGYPLTWFVQKKVSRGASAGRVQSVALGLIVKREREIQSFVPVEYWTIDAELEKDGRAFTAGLVAFEGMKKGAKIRPEFGPAGPAIPDEATANRLVEGFRRATFTVEAVKQGQRKVAPAPPFTTSTFQQAAVNRLGMSTARAMSVAQELYEGVNGMPGLITYMRTDSVAVSPVAQQQARAFIRETWGADFVPEKPRAYRTRARGAQEAHEAIRPTNPALRPEELRRSLSAEQLKVYDLIWRRFMASQMTDAVYRTVTVDIAAKAEGAPAGSFRANASTLVFEGHLKVYGAEAAETDEDGEQVVDALPEMAAGEALERRAVEAKRHETQPPPRYTEASLVRALEELGIGRPSTYASIVQTVLKREYVRKEGRQLVPQELGFIVHDLLEQHMKKYVDVPFTGEMEEELDEVASGERDWMEVLREFWPEFKAELERAEAEAEKEQQQTDILCEGCGQANLVIKWGRNGKFFGCPRYPECTFTLPMGPDGKPVKASAPEEIPYRCPKDGGKLLKKTGRFGAYVECENRAGGSCDFRAGVPVGVPCPEEPETGQLVEKSSRRGTFYACWNYPNCSYTTNSLEPGKMTPPRSPEVREEANRKLLERSARGKAAFAKRRANAAARKAS

(WP_012259747.1) MULTISPECIES: type I DNA topoisomerase [Chloroflexus aurantiacus J-10-fl]

2

MGEKVVIVESPAKARTIQKYLGKGYKVASSMGHVRDLPKSGLAIDIEHDFAPSYEIVKPKVVSELSQALRNAEAVYLATDPDREGEAIAWHITQAVKLPKKTPVYRVVFQEITRNAVQQALQQPRQINQNLVEAQQARRVLDRLVGYQLSPLLWDKVKRGLSAGRVQSVAVRLIVEREREIEQFQPQEYWTIEADLLKDAGVAPRDLFRAVLIERDGKKLEKFSIENREQAEAIVADLQGAAYTVVRVTRRDKRRSPAPPFTTSTLQQEAARKLGFSAKKTMTLAQRLYEGVDIGGEDGMVGLITYMRTDSVQVAAEAQTEARDVIGKRFGKEYLPDQPPVYKTKAKGAQEAHEAIRPTSSARLPEQLSGKLENDLWRLYDLIWKRFIASQMAPAVFDSTTVDIAATPVVAGAPAYLFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPPLAEGEALQLVELLPIQHFTEPPPRYTEASLVKELERLGIGRPSTYASILSTIQEREYVEMVDKKLIPTTLGRVVTDLLVEHFGNIVDYDFTSALEQQLDDIAEGSKKWVPVLREFYGPFRSTLEQAQRQMRNVKREEIVTDLDCPKCGQGKLVIRFGRNGEFLACSRYNREGDGESCDFTSDFHRDEQGQIVIDKASAPETSDVLCNVCGRPMVIKKSRFGPFLGCSGYPECNNTRRIGRDGKPVPLPEPTGVQCPKCGEGELLRRRGKFGRPFYGCSRYPKCDYITNTLDEAQAGEAPAEPAKNEPALPSPSRSSKRTRKSA

(WP_012616618.1) type I DNA topoisomerase [Chloroflexus aggregans DSM 9485]

2

MGEKVVIVESPAKARTIQKYLGKGYKVTSSMGHVRDLPKNGLAIDIEHDFAPSYEIVKPKVVSELNQAVRNADAIYLATDPDREGEAIAWHITQAVKTPKKTPIYRVVFQEITRNAVQQALQQPRQINQNLVDAQQARRVLDRLVGYQLSPLLWDKVKRGLSAGRVQSVAVRLIVEREREIENFKPQEYWTIEADLLKEAGIAPRDLFRATLIERDGKKLEKFSIERREQAEAIVADLQGAAYTVLKVTRRDKRRSPPPPFTTSTLQQEAARKLGFSAKKTMMLAQRLYEGVDIGGEEGMVGLITYMRTDSVQVAAEAQAEAREVIDRRFGREYLPDQPPVYKIKAKGAQEAHEAIRPTSSARTPEQLSERLERDLWRLYDLIWKRFIASQMAPAIFDSTTVDIAAQPSVAGAPPYLFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPPLVEGENLQLVELLPVQHFTEPPPRYTEASLVKELERLGIGRPSTYATILSTIQEREYVEMVDKKLIPTMLGRIVTDLLVEHFGNIVDYDFTSSLEQQLDDIAEGSKQWVPVLREFYGPFRSTLETAQRQMRNVKREEIITDLDCPKCGKGKLVIKFGRNGEFLACSRYNREGEGDSCDFTGDFHRDENGNIVLDQASAPETSDVLCNVCGRPMVIKKSRFGPFLGCSGYPECTNTRRIGRDGKPVPLPEPTGVTCPKCGEGELLRRRGKFGRPFYGCSRYPKCDYITNSLDEAQAGVAVEAAPALPPTVEKPAAPARKSSGKTRKSA

(WP_012120209.1) type I DNA topoisomerase [Roseiflexus castenholzii DSM 13941]

2

MGEKLVIVESPAKARTIQKYLGSGYRVEASMGHVRDLPKSNLGVDLEANFAPVYEISPGKEKIIAALRKSIRQADAVYLATDPDREGEAIAWHITEAAKIPRDKPVYRVVFTEITPGAVRSAMASPRDIDRRLVDAQQARRVLDRLVGYKLSPLLWEKVRRGLSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQNASDSQRDAFRAMLIERSGKKLEKFDIGASDQAQAIIADLEGAAYIVRKVTRRDKRRSPAPPFTTSTLQQEAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARRVIRERFGEAYLPAKPPVYKTKAKGAQEAHEAIRPTLSRRTPEQVQPYLTSDQYRLYDLIWKRFVASQMEAAVFDSTVVDIGAGRDIGGRGAGSDPYTFRATGSVLKFPGFLAVYNVSLDEGEEDEDSERRLPLLEEGEALNLLQLLPVQHFTEPPPRFTEASLVKELERLGIGRPSTYAPTISTIIEREYVELADKKLVPTTLGRVVTDLLVEHFPSIVDYGFTSEMEQQLDDIAEGEKEWAPVLRAFYRPFEQKLAEAQRSMRNVKREEILTDLTCPRCNQGQLAVKFGRNGEFLACNRYPECDFTSDFHRDSDGRIVLDAPASPETSDVLCDVCGRPMILKKSRFGPFLGCSGYPECKNTRRLDKQGKPAPLPKATGVTCPKCGQGELLERRGKFGRPFFGCNRYPKCDYLVNSLDEVAHYTPDANEASKPQAEEPTATDAKATPARKRVKTDANGAAAAGKRVKTDANGAVAGEPMKTKASANGKRAKTGTNGAAAAPPKKRGTER

(WP_012874441.1) type I DNA topoisomerase [Thermobaculum terrenum ATCC BAA-798]

2

MANKLVIVESPTKAKTISRYLGRGYSIKASMGHVRDLPKSKLGVDTEHDFQPQYLIPRDKSKTVKELKESVASAREVYLATDPDREGEAIAWHLIQATGMDTSKARRVVFHEITPDAVRNAMANPREIDMRLVDAQQARRVLDRLVGYNISPLLWKKVKRGLSAGRVQSVALRLVVDREREIQSFVPVEYWTISADLAKQPAKGRKPSRKDQFRALLVRINDEKVEISNEEQARAIIEALEGATYKVLEVKQREIQRKPAPPFITSTMQQEASRKLNFNARRTMSVAQSLYEGVSLGDEGDVGLITYMRTDSTNVATVAQEEARQVIAQLFGDKYLPEKPPVYTKKAKNAQEAHEAIRPTSVKRHPDAIKQYLTSDQYKLYKLIWQRFIASQMANAIIDGTTVDIAAEPRSGGAPYIFRATGSVIKFDGFLVVYQEGKDDDQEEELGSKALPPMTEGEVLNLIQLLPEQHFTQPPPRYTEASLVKALEEQGIGRPSTYAIILSTLQERYYVVKDGKALVPTELGMLVNDLLVEHFPDIVDVNFTSQMEEELDDIASGERAWVPVIKEFYGPFERKVRIAEEEMQKVDIQDEPAGENCPNCGRPMVFKMGRYGKFIACSGFPECRTTKAIVNRTGVQCPACRQGELVERRSRKGRRSIFYACDRYPDCEFTISAKPLPQPCPACGGLQVEDGKNGQKCIRCDGQGNILQKSA

(WP_013560005.1) type I DNA topoisomerase [Anaerolinea thermophila UNI-1]

2

MVIEAYCVKCKTKREIQDPVAEFTATGSPVTRGVCPVCGTKIFRLGKTPEHEKLTPPESVRKEKTKTRSGKLVIVESPAKAKTVGRFLGKGFTVKASVGHVRDLLRSELSVDIEHDFQPKYRVPNEKRAVVKELKALAQEAEEIYLATDPDREGEAIAWHLMQAAEIDPRLSKRVVFHEITKPAIDEAFSHPREINMALVDAQQARRVLDRLVGYNLSPLLWEKVRSRLSAGRVQSVALRLIVEREREIQAFIPVEYWSIEAELQPEGVSSTFIAKLSKIDEQDPELPNQEVVSRYLADLEQALFIISKIRRSERRRKPAAPFITSTLQQEASRRLGFTARRTMAIAQQLYEGLDVGEGGTTGLITYMRTDSTNISEVALREVREFIKETYGGSYLPESPLQYKTRAVSAQEAHEAIRPTSVARTPEKVKPYLSPEQYKLYQLVWQRFVACQMESAVYDTLSVEVDAKGEEHQYLFRASGSTLKFPGFLVVYEESRDEDQVSEDEGTETRIPAHIQEGQKQELVRLIPEQHFTQPPPRYTEATLVQVLEENGIGRPSTYAPILSTIQERGYVVRDGKRLVPTETGILVNDLIVAHFPDIVDTGFTAKMEEDLDRIAAGNEKWVNVIRQFYQSFSPQVERARMLMPESKSEPEKVGRQCPQCGHDLIVRWGRFGKFISCSNFPNCRYTEPWLEKIGVRCPKDGGEIVERRTRKGRVFYGCENYPNCDFTSWKRPIPASCPQCSGMLVIANKREVQCLSCQEMFLMEQFVENVEVNQP

(WP_232528581.1) type I DNA topoisomerase [Pelolinea submarina]

2

MEAYCMKCKEKREIQNPTAGFNSRGTPVTTGTCAVCGTKLYRMGRTDAHEGLIPPEPVPGAKKTKSGKTATAKRKGKMVIVESPAKARTVGNFLGKDYIVKASVGHVRDLLRSQLSVDVENNFEPKYRVPNEKRPIVKELKADAQKVEEIYLATDPDREGEAIAWHLMEAAELDEGRVKRVVFHEITKPAIAEAFSNPREIDINLVDAQQARRILDRLVGYNLTPLLWEKVRGRLSAGRVQSVTLKLIIEREREIEAFVPEEYWTIDGEFKPENQKDTFTARLVKIDDQDPQLPMQGVVDGLLADLKASHYTVSKIKRGTRRRKPFAPFTTSTMQQQASRQLGFTAKRTMRIAQQLYEGIDIGEGGETGLITYMRTDSTNISPLAIKEVRDYIKEVHGPEFVPETENKHQTKAMKAQEAHEAVRPTSVMRVPEKLKPFLKPEQFKLYQLIWRRFVASQMEAAVYETLSIEINGDGKDHQYLFRASGSQIQFPGFLVLYEEAKDDDSNGDENKELKIPEDLLEGQLILLVKLNPEQHFTQPPPRFTEASLVQTLEELGIGRPSTYAPIISTIQARGYVERDGKRLIPTDTGFTVNDLLVEYFPDVLGVNFTAHMEEDLDEIASGEREWRKVIADFYQSFEPQLKRAQDEMPETKMEPEKIGKACPQCGNDLVIKWGRFGKFISCSDYPNCKYTEPYLEKIGVLCPKDGGEIVIRKTRKGRIFYGCENYPNCDFTSWKQPISTPCPSCSGLLTFKNKNEYQCMNCEETFLISSINVEESESA

(WP_010936459.1) type I DNA topoisomerase [Dehalococcoides mccartyi 195]

2

MKEKLVIVESPAKARTISKMLGKDFNIMATMGHIRDLPKSTLGVDVENSFTPKYVSLKAKAKVIKELKDAVKNSKAIYLATDPDREGEAIAWHISEVTKANLAKPKRVVFHEITKEAIDKAFKNTRELDMDLVNAQQARRVLDRLVGYKLSPLLWRKVQRGLSAGRVQSVSLKIIVDREREIEKFVSAEYWNIEALLNKKVKSAAFKASLAGYVTKGKLEIHNESEAEQIKKELEVSDYQVLKIKKKSNLRQSPAPFITSTLQQEAWRKLHFSAKQTMVIAQQLYEGLNIEGEGEVGLITYMRTDSTNVARTAVAETRDYISEKYGPAYLPKQARVFSSKVKGAQEAHEAIRPTRIIRTPDLIKKSLSTEQFKLYQLIWQRMMASQMSPAVFDNTTIDIEAKHQPSKTRYLLRTTSSVNTFPGFTIVYIEGKDEDEEAAQSSLPPMEEGEELKLKSLEASQHFTQPPPRYTEATLIKALEQYGIGRPSTYAPTISTIQEREYITKLKGSLKPSELGMLVNDLLVEYFPDIIGIDFTAAMETELDKIATEKLDWVPIIRRFYEPFIKEIEAASEKIEKIKPPEEELDELCPECNAKLVVKRGRFGKFIACSRYTKEEGGCRYTRSYQIKTGAKCPECNSDIVEKYSKKGKIFYGCAGYPNCKFVSFYKPLSKPCPECGALMIKSGKNWAKCTKCGKRKKLEDES

(WP_102330518.1) type I DNA topoisomerase [Dehalogenimonas etheniformans]

2

MATDKKLVIVESPAKARTLAKFLGSGYTLKASMGHVRDLPKSKLGVDVDHDFAPQYLNMRDKLTVLKELKEAAKKAGTVYLATDPDREGEAIAWHLKEATCTPSVPCRRVTFHEITKEAIAAAFKSPRDVNMNLVNAQQARRILDRLVGYKLSPLLWQKVRRGLSAGRVQSVALRIIVDREREILGFKADEYWTIEVELSKLVPSTPKSFKALLIGSGDKKKIAIGNEAAAGDIVADLKPAEYSVAKVTSKDSPRQPAPPFITSTLQQEAYRKLRFSAKQTMAVAQQLYEGLSVGAEGSVGLITYMRTDSTHVASSAIAETRDFIAEKFGSNFLPKSPRLFARQVKGAQEAHEAIRPTSTRREPAAIREFLEPNQFKLYQLIWQRMVASQMAAAVFENVTIDIDARKTPSKTRYTLRAQNSKNTFPGFMALYTEGRDEEEEAKTPPLPSLSENEMLKLLDPKAGIKPEQHFTQPPPRFTEATLVKTLEQFGIGRPSTYAPILGVVQEREYVTKDKGAFKPTELGVAVSDLLVQQFPEVIDTGFTAQMEDKLDKVADEGLDWVKVVRDFYAPFEKDLATAEEQLERVPMPIEISDECCPQCSKEKLLIKVGRFGKYMECPACGFRQSFRIRTGVMCPNCPEKGEIIGRYTKKGKLFYGCSAFPKHSFAMNAKPLPEPCPKCGGIMGELKPGQKSCQNPECADYKGKRFFRRSTTSSAASSSKSTTAKAKIKTSAKRAKPTRSKPTAKEK

(WP_076003849.1) type I DNA topoisomerase [Dehalogenimonas formicexedens]

2

MATDKKLVIVESPAKARTLAKFLGSGYTLKASMGHVRDLPKSKLGVDVDHDFNPQYLNMRDKLAILKELKEAAKKAGAVYLATDPDREGEAIAWHLKEAACTPSVPCRRVTFHEITREAIAAAFKSPREVNMNLVNAQQARRILDRLVGYKLSPLLWQKVRRGLSAGRVQSVALRIIVDREREILGFKADEYWTIEAELSKLVPSTPKSFKAILIGSGDKKKISIGTGTAASDIVADLKPAEYSVARVTSKDSPRQPAPPFITSSLQQEAYRKLRFSARQTMAVAQQLYEGLPVGAEGSVGLITYMRTDSTHVAASAIAETRDFIAEKFGSGFLPKTARLFARQVKGAQEAHEAIRPTSTRREPAAIKEYLEPNQFKLYQLIWQRMVASQMAAAVFENVTIDIDARKTPSKTRYTLRAQSSRNTFPGFMALYTEGRDEEEEAKTPPLPPLSEGELLKLLDPKASVSPEQHFTQPPPRFTEATLVKTLEQFGIGRPSTYAPILGVVQEREYVTKEKGAFKPTELGMAVSDLLVQQFPEVIDTGFTAQMEDRLDKVADEGLDWVKVVRDFYVPFEKDLSTAEEQLERVPMPVEVSEDCCPQCAKEKLLIKIGRFGKYMECPACGFRQSFRIRTGVMCPNCPEKGEIIGRYTKKGKLFYGCSAFPKHSFAMNARPLPEPCPKCGGLMGELKPGQKSCQNPECADYKGKRFLRRSKTASTSPRSRSVSTGSKTAAAVKRTKAGQNKSRPEEK

(WP_129893217.1) type I DNA topoisomerase [Ktedonosporobacter rubrisoli]

2

MAKKLVIVESPAKAKTIEKFLGRDFVVLASMGHIIDLPKKGLGVNTRKNFVPQYEVIEKKDRLIDELKKASLRADEVYLAPDPDREGEFIAWSLKNILGLQNPHRAVFHEITKRAVQEAIKKPREIDEDLFNAQQARRVLDRLVGYKISPLLWRRIQSGTSAGRVQSVALRLICDREAEIRAFVPEEYWSITATLSKQKQKERFEATLITRLKDMAMLNEEANEGEEQNGAEGQNTAGAKKEKGRIKVGSKEEADAILADLQGATYSVLKYEEREQRRQPYLPYTTSTMQQDASVRLYFKPKKTMSLAQQLYEGIELGQRGHQGLITYMRTDSTRISDEAQAAVKTYIAGEHGQNYVGPGRVGKAKATTQDAHEAIRPTDVNLTPQVVKSYLTPDQFKLYNLIWRRFVASFMAAAIFDTVRVDIVARQYVFRATGSNLKFPGFYAVWPREEDEKILPVMQVKEELDFHGLKPEQHFTQPPPRFTEASLIKELEEQGIGRPSTYVPIISTIQDRGYVDQEQRRFLPTWLGETVNDVMNKHFPEIVDTRFTAEMERKLDEVEEGRYSWTEFLHSFYGDFKESMKKAEAEMDRVQKPLEELDEVCPECGRNLVIRTGRFGRFISCSGFPECSYRRSFVNKTGALCPLCNGDLVERKTRQKKRIFYGCANYPTCNFAIWERPVPDLCPNCGGLMVVPKAGQAPVCYAEYVAGQRDAEEKPVQENVKKTTRTSRKKASTTESTAKAAKPSRRRTTAKKQEEADTPAEATNGTAKRATTRSSATRTRKSASSTGKATTRSRSTASKESSSGKTRTRAAK

(WP_014431876.1) MULTISPECIES: type I DNA topoisomerase [Caldilinea aerophila DSM 14535 = NBRC 104270]

12

MGKKLVIVESPTKAKTIGKFLPKEYLVKASMGHVRDLPASAAEIPEKEKNKPWARLGVNVEADFEPLYVIPESKRKVVAELKAALKDAEELILATDEDREGESIGWHLREVLKPKQPVRRMVFHEITREAIEQALRETRDLDLNLVHAQETRRILDRLVGYTLSPLLWRKIAPRLSAGRVQSVAVRLLVQRERERRAFVPGQYWDLRALLNKRPDQPGHRFEATLVSVGGQRIASGRDFDERTGQIAAGKDVLLLNQQEAEALRARLLDGEWTVVEVEEKDATRAPYAPFTTSTLQQEANRKLGMSAKETMRIAQNLYENGYITYMRTDSVHLSDEAIHAARRRIREMYGEEYLSPSPRRYQTKTANAQEAHEAIRPAGDQMSPPDSLPLEGREKALYELIWKRTIASQMANARLKLRTVMIAVDNALFRASGRTILFPGFFRAYVEGSDDPDAALESQEQPLPALSVGEIVDCRELEAIGHETQPPPRYTEATLVKALEAEGIGRPSTYATIIDTILQRGYAFKQRKELVPTFTAFAVTALLEKHFQELVDLKFTANMEQRLDDIATGAADHLAYLREFYLGEGGLEHQVKSREAAIDPREASTVALDDLHAEVRIGQYGPFIVREEDGERLTAGLPPTLPPADLTDHLVEELLNKKVEGPQMLGVDPESGLPVLLKTGPYGPYVQLGEDDPEGKTKPKRASLLKGMNPEELTVETALALLSLPRTLGEHPETGKPVQAGVGRFGPYVVHDGVYVNLRPPDSVLDIELDRALELLAAKASGGKGRSTGKSVIKELGEHPEGGAVQVLDGRYGPYVSWKKINVTVPKDIQPADVTLEQALAWIAEKRAKPASTRKRATKSTKTAASKPLE

(WP_195171124.1) type I DNA topoisomerase [Phototrophicus methaneseepsis]

1

MKLVIVESPAKAKKIAHFLGDGWQVEACRGHVRDLPETELGVDIDADFRPQYQVLAGKGNLVKKLVKAIREADAVYLATDPDREGEAIAWHLLALAGNLKDKPVYRSAFNAITESAVKAALAEPRSLDQSLVEAQSVRRIVDRLVGYLVSPLACKALNGRLSAGRVQSVALRLVVEREREIEAFKVESFWTLKAILEANDSRFEAKLHRLKDADVKFNAREQAEKLVGLLQSASFRVNKAGQTLKLRNPLPPFTTSSLQQAAAKGLGLSPEKTMQLAQTLYEQGRITYHRTDGVSVAVEAQQAAGLLILKDYGTEYLPETPPVYKTRTANAQEAHEGIRPTDVSHLPEANDGDAAKLYALIWKRFVASQMAPARYTVTAALIHAGKAVDKPFPLIFKAQGRVLDFDGFLRVYEEPDDVDQSEAEDSGAVPALKDGQTLHLVELPIDEGQTRPPARFSEAALVQKLEAVGVGRPSTFASMLKVIKDKKYVALKQKRLQPTETGTQLNDFVVERFPQVFDVAYTARLETALDRVANDDLSRSDLLSAFWRGFQPQLKAATEYTLTQMKARPQAKPIGETCPECDADLVERQGSNGVFVGCSAYPKCSYTRNVEHKPLVLHPVED

(WP_195171680.1) type I DNA topoisomerase [Phototrophicus methaneseepsis]

1

MKLVIVESPAKAKKIAGYLGDGWQIEACRGHVRDLPESQLGVDVEQDFRPQYVMLPGKGNLVERLVKLIRKADEVYLATDPDREGEAIAWHLLQLAGDLKNKPVYRAAFHAITEEAVQAALADPRPLDAALVEAQSARRVVDRLVGYLVSPLACKTLDDRLSAGRVQSVALRLVVEREQQIAAFQSDTTWGVEAILEASGTRFEAKLHRLKDADIPFKDAAQAEKLLTLLKRASFWVSKTGQTTKHRNPLPPFTTSTLQQVASKGLGLSPEKTMSLAQMLYEQGRITYHRTDSVAVAQEAQTVAREVISREYGERYLPTASPIYKAKTANAQEAHEAIRPTDISQMPAVHPEGDVPSSNAAKLYDLIWRRFIASQMTPADYTVTAILIRVGRSQDKPYPLSFKANGRELTFDGFLRVYEEPDDVDAGVDAEAVEIGSVPSLRDGQILKRVDVAVNESQTRPPSRYSEAALVQALEKYGVGRPSTFASMVAVIKHKKYVTVKQKHLVPTKNGMKLCAFLIERFPQVFDMDYTARLEAALDQVASGQLSRSRLLNTFWRGFQPQLKSATEYALTQVKSRPKAKLIGETCPDCGGDLVERQGANGVFVGCTNYPSCTYTRSTGHQPLTLHPAEGA

(WP_195168925.1) type I DNA topoisomerase [Phototrophicus methaneseepsis]

2

MSDPMRGYCMKCKEKRDMIEPQATYTKSGVPATTGKCAVCGTKIFVMGETPAHANVPKPEVIERPKKTKKKAKKGAKKAKSTRSKKVGKLVIVESPAKARSIGSYLGDGYTVMASKGHVRDLLVTQLSVDVENDFEPKYRVPNDKRQTVKQIKQAVEGAEEVYLATDPDREGEAIAWHLAEAIGMDDTQAQRVTFNEITRDAVRESFDSARNIDMDLVNAQQARRVLDRLVGYNITELLWDKVRNRLSAGRVQSIALRLVVDREEEIEAFNPEEYWTIEAELAKQSTNGHQPESFVARLAKINGDDVNLTSDSEVQPHVDILEKSQYLITDVKIGTRRRKPSAPFTTSTLQQEASRRLGFNARRTMRAAQSLYEGVELDNGEIVGLITYMRTDSLNISAQAQQEARNYIVENFGKEYAPEKVRNYKTKAKGAQEAHEAIRPTSVLRAPLEIKKALQGAGRDLFKLYQLIWERFVSSQMSNAVYDTVRAEISAGLNTNDMPYLFRASGSRIRFKGFLAVYEESRDEDAPQITDDRMLPELLADELLNLVQLLPQQHFTQPPPRYTEASLVRTLEELGIGRPSTYAPTVAVIQDRDYVTKEDKRLVPTDTGKVVSDLLVKFFAEEMDYQFTARLEDQLDEISQGGTEWQPFMHDFYEPFSVRLQNARSNMPQMKQEELVGRKCPTCGTGDLVIKYGRWGKFIGCSNYPECRHTEQYLEYIGVPCPVCGEEHGGEVVELKSRRGRTFYGCSRYPDCDYRSWNRPGSDQEQEATEDKEAVHEEAS

(WP_158067733.1) MULTISPECIES: type I DNA topoisomerase [Tepidiforma bonchosmolovskayae]

1

MATATATRRRRKTDAEAPALEGGSAAAPARGRKGPRYLVVVESPTKARTLQSILGSDYEVIASLGHVRDLPTYGYGVENVEQLDFRPKYVVVKDRNARVDKAEVIREIAEAAKRAERVFLSTDPDREGEAIAWHIKEAAGIPDEKVTRVVFHEITRPAIEAAFAEALGQAPASAEHGRREPGKLDMHLVDAQQARRVLDRLIGYPLTWFVQKKVSRGASAGRVQSVALGLIVKREREIQSFVPVEYWTIDAELEKDGRAFTAGLVAFEGMKKGAKIRPEFGPAGPAIPDEATANRLVEGFRRATFTVEAVKQGQRKVAPAPPFTTSTFQQAAVNRLGMSTARAMSVAQELYEGVNGMPGLITYMRTDSVAVSPVAQQQARAFIRETWGADFVPEKPRAYRTRARGAQEAHEAIRPTNPALRPEELRRSLSAEQLKVYDLIWRRFMASQMTDAVYRTVTVDIAAKAEGAPAGSFRANASTLVFEGHLKVYGAEAAETDEDGEQVVDALPEMAAGEALERRAVEAKRHETQPPPRYTEASLVRALEELGIGRPSTYASIVQTVLKREYVRKEGRQLVPQELGFIVHDLLEQHMKKYVDVPFTGEMEEELDEVASGERDWMEVLREFWPEFKAELERAEAEAEKEQQQTDILCEGCGQANLVIKWGRNGKFFGCPRYPECTFTLPMGPDGKPVKASAPEEIPYRCPKDGGKLLKKTGRFGAYVECENRAGGSCDFRAGVPVGVPCPEEPETGQLVEKSSRRGTFYACWNYPNCSYTTNSLEPGKMTPPRSPEVREEANRKLLERSARGKAAFAKRRANAAARKAS

Name	Chloroflexota
Rank	phylum
Topoisomerases	15

Lineage	Bacteria > Bacillati > Chloroflexota
Sub-taxa

Taxon : Chloroflexota