Home | TopoIBase

Name	Family	Sequence
(WP_048084841.1) DNA topoisomerase I [Methanobacterium formicicum]	5	MHEVIVCEKPKASEKIAGAIPGKAVKKSYKKVPYYEIEKDGKKTTVLSAVGHLYSLSPLKKEKGRMFEVGWVPLYEKDKSKRYVKNYIDAIKKFSKNADRFVHACDYDIEGTLIGFNALKYACGEDSIDKAVRMKFSTLTKEDLLKAYNEPIDLDFNQVDSGEARHVLDFIFGVNISKDLTDSVMKATSRYIQLSAGRVQTPTLAILVEREKEIQSFIPEPYWLIKAKVEGRIIADHKKGKIFDKKVQEEILADCEGKDAQVSKISVKETPQLPPVPFDLGSLQSEAYGVFGFSPKKTQSIAQNLYAEGYTSYPRTSSQKLPPSIGYKKILGQLKKNAAFRKQIDKLKEPIKPREGKKTDEAHPAIHPTGLVPKGLGRDYQKLYELIVYRFISVFGENGILETMKTELDIGGQEFSFSRKRMAKMGWREHYPYRKVENDEFPALKEGDLLGAQAYSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKYVEGKKIAVNQLGERLIDTLKKYSEKITSEELTREFETKLGGIMKAEVKKEEIITEAKEEVSSILDDIDANKMKVGQELYSAYRESMIVGKCKCGGNLIMINSPKGGSFVGCTSYPDCKSTYSMPRGATVLKTKCEECGLPMISFGKPRQRACMDPKCGRDGEEPLQNEVVGVCPDCGKDLIKRRGRYGEFVGCSGFPRCRYTRSLEEKQEQTTKKSEKT
(WP_100909272.1) DNA topoisomerase I [Methanobacterium subterraneum]	5	MHEVIVCEKPKASEKIAGAIPGKAVKKSYKKVPYYEIEEGGKKTTVLSAVGHLYSLSPLKKEKGRMFEVGWVPLYEKDKSKKYVKNYIDAIKKFSKNADRFIHACDYDIEGTLIGFNALKYACGEDSIDNVVRMKFSTLTKEDLLRAYNEPIELDFNQVDSGEARHVLDFIFGVNISKNLTDSVMKATSRYIQLSAGRVQTPTLAILVEREKEIQSFIPEPYWLIKAKIEGNIIADHKKGKIFDKKVQDEILADCEGKDARVSKIGIKETPQLPPVPFDLGSLQSEAYGVFGFSPKKTQSIAQNLYAEGYTSYPRTSSQKLPPSIGYKKILGQLQKNAAFRKQIEKLKEPIKPREGKKTDEAHPAIHPTGLIPKGLGRDYQKLYELIVYRFISVFGENGLLETMKTQLDIGGQEFSFSRKRMAKMGWREHYPYRKVENDEFPALKEGDCLDARAYSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKYVEGQKISVNQLGEHLIDTLKKYSEKITSEELTREFETKLEGIMKAEVKKDEIITEAKSEVSSILDDIDANKMKIGEELYAAYRESMIVGKCKCGGNLIMINSQKGGSFVGCTSYPDCKSTYSMPRGATVLKTKCEECGLPMISFGKPRQRACMDPKCGRDGDEPLQNEVVGVCPDCGKDLIKRRGRYGEFVGCSGFPRCRYTRSLEEKQEPADEKS
(WP_071907366.1) DNA topoisomerase I [Methanobacterium congolense]	5	MHEVIICEKPKASEKISAALSKNAVKKSYKKVPYYEFEENGKKTTVLTAVGHLYSLSPKDRKQKKLFDVEWVPLYEKDKKKKYVKNYVDAIKKLSKNADRFVHACDYDIEGTLIGYNALKYACGEKSLDNAVRMKFSTLTEEDLIEAYEHPLEIDFKQVDSGIARHVLDFFFGVNMSKYLTDSVMKATKRYIQLSAGRVQTPTLSILVDREKEISKFVPVPYWLIKADLDVSGVDEIITADHKKGKIMERKDADAILSECEGKDALVSGVDLKKTKKTPPVPFDLGSLQSEAYAVFGFSPRKTQQIAQNLYTEGYTSYPRTSSQKLPKSIGYDKILKKLSYNSAFGKQISKLKKPYKPNEGKKTDEAHPAIHPTGLLPKEISTDYRKIYELITYRFISVFGEDALLETMKTRLEIGKEEFSFSKKRMAKMGWMEHYPFKKVENDEFPNITEGETIDVKEVRAEDKETKPPARYNQASLIRELEKRGLGTKSTRANIIDILYNRKYVEGKKIVVNELGEHLIDTLKKYSSKITSEELTREFEEKMEGIMEGNTKKGEVIKEAEVEVASILDDIESNKLKIGEELYAAYRESRVVGKCKCGHNLILIDSPRGGSFVGCSGYPDCKSTYSLPRGASILKTTCEKCGLPMISFGKPRQRACLDPKCGKEGKEPTNEVVGKCPECGSNLIKRSGRYGEFIGCSGFPKCRFTQSIEKGD
(WP_286242944.1) DNA topoisomerase I [Methanobacterium ferruginis]	5	MHEVIVCEKPKASEKIASAIPGKAVKKSYKRVPYYEIDEGNKKTTVLSAVGHLYSLSPLKKEKGRMFEVGWVPLYEKDKSKKYVKNYIDAIKKFSKDADRFVHACDYDIEGTLIGFNALKYACGPESIDNAVRMKFSTLTKEDLLKAYNEPIDLDFNQVDSGEARHVLDFLFGVNISKDLTDSVMKATSRYIQLSAGRVQTPTLAILVEREKEIQSFIPEPYWLIKAEIEGNIIADHKKGKIFDKKVEEEILADCDGKDARVSQIKVKETPQLPPVPFDLGALQSEAYGVFGFSPKKTQSIAQNLYAEGYTSYPRTSSQKLPPSIGYKKILGKLKKNAAFKKQIEKLKEPIKPREGKKTDEAHPAIHPTGLVPKGLGRDYQKLYELIVYRFISVFGENGILETMKTELDIGGQPFSFSRKRMAKMGWREHYPYRKVENDEFPALKEGDSLGARAYSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKYVEGKKITVNQLGEHLIDTLKKYSEKITSEELTREFETKLEGIMKAEVKKDEIIAEAKAEVSSILDDIDANKIKIGEELYASYRESMIVGKCKCGGNLIMINSPKGGSFVGCTSYPDCKSTYSMPRGATVLKTKCEKCGLPMISFGKPRQRACMDPKCGREGEEPTQNEVVGVCPECGKDLIKRRGRYGEFVGCSGFPRCRYTRSLEEKEDQKSEKT
(WP_013826367.1) DNA topoisomerase I [Methanobacterium paludis]	5	MHEVIICEKPKAAEKISSALSKGAAKKHYKKVPYYEFEENGKKTTVLTAVGHLYSLAPKDKKQDKLFDVEWVPLYEKDKKKKYVKNYIDAIKKLSKDADTFVHACDYDIEGTLIGYNALKYACGDESLKNVMRMKFSTLTDEDILKAYKKPMELDFKQVDSGIARHVLDFFFGVNMSKHLTDSVMKATKRYIQLSAGRVQTPTLSILVDREKEIKEFIPVPYWLIKADLDVTGVKEGITADHKKGKILEKKDADAILVECKGKDAVITEVNLRKTTKTPPFPFDLGSLQSEAYGVFGFSPRKTQQIAQNLYTEGYTSYPRTSSQKLPKSIGYDKILKKLSYSSAFGNHVAQLKKPYKPNEGKKTDEAHPAIHPTGVLPKELSTDYRKLYELIVYRFISVFGENATLETMKTTLTIGKEEFNFSRKRMSKMGWMGHYPFRKIEEDYFPTMNKGETLNVKEVRAEDKETKPPARYNQASLIRELEKRGLGTKSTRANIIDILFSRKYVEGKKITVNKLGEQLIDTLRKYSKKITSEELTREFETKLEGIMEGKDKKDKIIDEARVEVSSILDDIEKNKLKIGEELYKSYRESRVVGKCKCGKNLILIDSPRGSTFVGCSGYPECKSTYSMPRGATVLKTTCEECGLPMISFGKPRQRACLDPKCGKDGREPTNEVVGKCPDCGSDLIKRSGRYGEFIGCSGFPKCRFTKSIDDDGGKTAAKTTGAPKKTVAKKAATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKNAKKTK
(WP_013644136.1) DNA topoisomerase I [Methanobacterium lacus]	5	MHEVIICEKPKASEKIASALSKNSTKKKYKKVSYYEFEENGNKTTVLTAVGHLYSLAPKNKNKGRLFDVEWVPLYAKDKKKKYVKDYVDAIKKFSKNADRFVHACDYDIEGTLIGYNALKYACGENSLDNAVRMKFSTLTNEDITAAYEKPLNIDFNQVDSGIARHVLDFLFGVNISKSLTESVMETTKRYIQLSAGRVQTPTLAILVEREKEIQKFIPEPYWMIKADLDVPGIDELVTADHKAGKIFDKNVADEIFADCDGKNAVVDGIDVRETVKAPPFPFDLGSLQSEAYAVFGFSPKKTQQIAQNLYTEGFTSYPRTSSQKLPKSIGVDKILKKLSYSGSFRNQIAKLKKPYKPNEGKKTDAAHPAIHPTGVIPKELSTDDRKLYELITYRFISVFGENGLLESMKTSLKIGDQDFSFSRKRMAKLGWMELTPFKKAENDSFPTISKDDELLVEAVRSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKFVEGKKIKVNELGEHLIDTLKEYSNKITSEEMTREFETRLEDIIEGSVNKDNIIEEAKIELTSILDDIDKNKAVIGEQLYKSYRESRVVGKCKCGGNLVLIDSPRSNSFVGCSGYPECKSTFSLPRGATILKTTCEECGLPMISFGKPRQRACLDPKCGKDGQEPSNEIVGVCPDCGKDLIKRSGRYGEFIGCSAFPKCRYTRSLDEPAPEVSGVPNSTNKPIKAAAKKSGKTAVKKATAKKSGKTAVKKATPKKSSRKVTKTRKVSKRSS
(WP_286473639.1) DNA topoisomerase I [Methanobacterium aridiramus]	5	MHEVIICEKPKAAEKISQALPGYAEKKNYKRVPYYEIEENGKKTTILAAVGHLYSLSPLKKENGRIFEVEWVPLHTKDKSKRYVKNYIDAIVKFSKDADKFIHACDYDIEGTLIGFNALKYACGDKSVEQAVRMKFSTLTDEDLLEAYHNPIDLDFHQVDSGIARHVLDFLFGVNISKYLTDSVMAATSRYIQLSAGRVQTPTLSILVDREKQIKEFKPEPYWLIKADLGLGIIADHKQGKIFDKKKTEDILAHCQGEDAVVDKISLKETAQSPPVPFDLGTLQSEAYSVFGFSPKKTQSIAQNLYTEGYTSYPRTSSQKLPASIGYQKILGKLSKNSSFAKHIKKLKKPLKPREGKKTDAAHPSIHPTGVLPNKLGRDYQKLYELIVHRFISVFGQNAILEAMKTDLKIGDEDFTFSRKRMAKMGWKEHYPFRKVENDEFPSLKEGEKLEAKVDSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKYVEGKKITVNQLGEHLIDTLKEYSEKITSEELTREFETRMEGIMSGETDKDDIIQQARVEVSSILDDIEKNKLKIGEQLYQAYRESMVVGSCKCGGNLITINSPRGGTFVGCSAYPECKSTYSLPQGANVLKATCEKCGLPMISFGKPRQRACLDPKCGREGEEPPKNEVVGVCPDCGKDLLKRLGRYGEFVGCSGFPRCRYTRSLEEDEEKVQEKS
(WP_211532577.1) DNA topoisomerase I [Methanobacterium alkalithermotolerans]	5	MHEVIICEKPKSSEKIAQALSPHAEKKTYKKVAYWEFEEEGKKTTVLSAVGHLYSLKPLNSKNEHFFDLEWIPLYDIDKKKSYVKDYVNAIKKFGKGADIFIHACDYDIEGTLIGYNALKYICGDKSVENALRMKFSTLTKEDVLNAYHKPIDLDFNQVDSGIARHVLDFIFGVNISKALMKSVRESTSRFIKLSAGRVQTPTLSILVDREKEIREFVPVPYWMIKALLEEGIVADNKKGKIWDKKEAEAVLSNCKGNDAVVDHIKLLNTTKKPPFPFDLGSLQSEAYGVFGFSPKRTQQIAQNLYTEGYTSYPRTSSQKLPKSIGYEGILEKLSKDSAFKKQIKKLPTPLKPNEGKKKDEAHPSIHPTGVLPKKLSTDDRKLYELIVYRFISVFGEDATLETMKTELKIGEEDFLFRRKRISYMGWLEHYPFRKVENDEFPDIKKGDRLKVKKIRSEEKETKPPARYNEASLIRELEKRGLGTKSTRADIIAILYDRKYIYGKQITVNQLGENIIDTLREYSPQITSEELTRQFENELQEIMAAEITKEKVIDDAKKEVISILEDVEKSKLKIGQKIYDAYQESRIVGECKCKGNLVLKYSPRNKSTFVGCSNYPDCKATYSLPRGASVLKTTCEKCSLPLISFGKPRQRACLDPKCGQDGKETKPEVVGKCPECGKQLLKRSGRYGEFIGCSGFPKCRFTQSLEEKEANKSG
(WP_011954063.1) MULTISPECIES: DNA topoisomerase I [Methanobrevibacter smithii ATCC 35061]	5	MNEVIICEKPKSAEKIAKALSSKAKKNVFNKKVKYWTLERDGKDITVLSAVGHLYSLTPDNPKDKVYFDLHWAPLFEIDKKYKNYTKDYVRAIKKYAKDADSYIHACDYDIEGTLIGYHALKYGCGDDALKKSSRMKFSTLTKKDIVEAYENRIPIDRHQVDSGVARHILDFYFGVNISKALMKSVSAAKKRFLKLSAGRVQTPTLSILVDREKEIKKFVPKPYWLIKALLDGEIEADHVDGKIFDKTRAEEIFSNCENSDAAVDKIKYSNSTTKPPVPFNLGGLQSEAYNVFGFSPKKTQTIAQSLYTAGYTSYPRTSSQKLPESLDFKSIFLQLSKNSEFRTHISALPAKLKPNEGKKEDAAHPAIHPTGILPDKLDKDELKIYELIVYRFISVFFEAATFETMSTTLDIGGEKFKFRRRRVTHKGWLEHYPFKKIDNEEFPDVKEGDSIIVKEIVSEEKETKPPARYNQASLIKELEKRELGTKATRADIIDKLYDRKYITGNKIEVNQLGENIIDTLSEYCSNLTSEELTRDFENKLEGIDNDKATRESVVAEGEKEVKVILGDIDKNKVKIGSQIYDAYQESNIVGKCKCGGNLVKKYSPKNKSTFVGCSNYPDCKATYSVPKGANFLKKTCKTCGLPIISFGKPRQHACLDPNCGKENTKPREMKVVGVCPSCGKELIKRSGRYGEFVGCRGFPKCRFTCSLDELKDKVQ
(WP_012955193.1) DNA topoisomerase I [Methanobrevibacter ruminantium M1]	5	MHEVIISEKPKSAEKIAKALSPNAQKKKYNRKINYWEFEENGKKTTVLSAVGHLYSLTSASSRDRLGFDLTWVPAYEVEKQKYTRDYINAIKKLSKGADKFVHACDYDVEGTLIGYNALKYACGNNAEAKASRMKFSTLTKKDIVEAYNTMRDIDIRQVDHGIARHMLDYYYGMNISSALMKAVRASSSRFISLSAGRVQTPTLSILVDREKEIQSFVPEPYWMIKAKSDYDIIADHVEGKIFDEERAKKIYADCQGADADVTSVKVTESIRKPPIPFNLGGLQSEAHTVFGFSPKRTQVAAQNLYVGGYTSYPRTSSQKLPESLDFKNIFAGLAKDPEFKKHIFDLPAKLKPNEGKKTDAAHPAIHPTGVLPSNLSADEAKIYSLIVYRFISVFSENSKLETMKVNLKVADEKFTFSRKRVSYEGWLKHYPFKKQENDAFPPINKGDQLKIHKILVEEKETKPPARYNEASLIKELEKRELGTKATRADIVAKLYDRKYIEGKKIEVKPLGINIIDTLNEYCKDLTSEELTREFERELEGIDTDKYTKEQILENGEKEVKTILAEINQNKKQIGEKLYGAYQETNVVGECSCGGKLIKRYSPRTKNTFVGCSNFPKCKVTYSLPKGANMLKKTCPTCGLPMISIKKASGKGRDHVCLDSNCGKDVSRRQAPEVVGKCPECGKDLLKRSGRYGEFVGCSGFPRCRFTCSVDELNNLGKDKNKEDVKENKGVSKKIVRSEAK
(WP_409198101.1) DNA topoisomerase I [Methanobrevibacter acididurans]	5	MHEIIICEKPKAAEKIAQAISPNVKKRKYNKKVSYWEIEEENKKITVLSAVGHLYSLTPVNPKSKVFFDLEWAPLYEIDKTKKYTRDYVYAIKKFSKDADKFIHACDYDIEGTLIGYNALKYACGQNTTANISRMKFSTLTKTDILDAYNNMIDLDLHQVESGSARHVLDFYFGVNISKSLMHSVRTAKKRFLKLSAGRVQTPTLSILVDREKQIKKFIPKPYWLIKALLNGEIIADHEDGKIFDKKRAEEIFDKCQNQNALVDEVKKTETIRKPPVPFNLGGLQSEAYGVFGFSPKKTQMIAQNLYTGGFTSYPRTSSQKLPKSLEYKKIFMQLSKNAEFKKHIQDLPSELKPNEGKKKDAAHPAIHPTGVLPDKLSKDELKIYELIVYRFISVFCENSKLESVKTDLLIADEKFNFKRKRVSYLGWLAHYPFKKIENENFLDIKKGDIIKVEKICSEQKETKPPARYNEASLIKELEKRELGTKATRADIIAKLYDRKYISGKKIEVNQLGENLIDTLKEYCEDLTSEDLTRDFEKRLEGISNDKTTQEAVVNDAEKEVKAILGDINKNEADIGDKLYDAYQQSRIVGECSCGGNLVMKYSPRNKSHFVGCSNYPECEITYSLPKGATFLKKTCPKCGLPIISFGKPRQHACLDPNCGKDNTKRHVVKVVGVCPDCGKDLVKRSGRYGDFVGCKSFPKCRFTCSLEELKDLESKSKK
(WP_067145196.1) DNA topoisomerase I [Methanobrevibacter olleyae]	5	MHEVIISEKPKSAEKIAKALSSKAQKKKYARKINYWEFEEDGKKTTVLSAVGHLYSLTSASSSDRLGFDLTWVPAYEVDKNSAYVRDYVYAIKKLSRDADKFVHACDYDIEGTLIGYNALKYACGNNAEAKASRMKFSTLTKKDIVEAYNNMIDIDPHQVDSGIARHMLDYYFGMNISSALMKAVLSSSSSRISLSAGRVQTPTLSILVDREKEIQAFVPEPYWQIKAKSDFDIIANHVEDKIFDEKRAKRIFDECQGADATVTNVNVRETIRKPPIPFNLGGLQSEAHTVFGFSPKRTQVAAQNLYVGGYTSYPRTSSQKLPESLGFKEIFAGLSKDEEFKKHVFDLPSKLKPNEGKKEDAAHPAIHPTGALPSNLSPDEEKIYRLIVYRFISVFSEDSKLETMKVNLNVNNEKFIFSRKRVSYEGWLKHYPFKKQEADEFPPLKKGDFLKIHKIISEEKETKPPARYNEASLIKELEKRELGTKATRADIIAKLYDRKYIDGKKIEVKPLGVHIIDTLKQYCKNLTSEELTREFEKELDSLSADKITKEEILANGEKEVESILKDINNNQKEIGSKLYESYQQSNIVGDCSCGGKLVKKYSRRTKQSFIGCSKFPQCRNTYSLPKNTNILKSKCPTCGLPMISIKKKGQKGREHVCLDPNCGKDLSKRRAPEVVGKCPECGKDLLKRSGRYGDFVGCSGFPKCRFTCNVKDLENLEKEKTDSKENKSKQMVKVKSK
(WP_011405969.1) MULTISPECIES: DNA topoisomerase I [Methanosphaera stadtmanae DSM 3091]	5	MSELIICEKPKVAEKVAKALSDSPVKNSYKRVPYYEFTNGNGTKITVLSAVGHLFSLKAKNKKDKRLFDVEWVPLSETDKSKKYVKNYIDTIKKFSKDADRFIHACDYDTEGTLIGFNALRYICGEDSIDKSFRMKFSALTKKDLIESYSNAYPLKEDKSWVDSGETRHVLDFLFGVNISKSMTDSVLNVTNRYVQLSAGRVQTPTLAILTEREKEIQKFIPEPYWLIKAKLQKSIVADHKKGKIFDKKEVDAILKNCKGKDATVEKITNRKTKKDLPVPFELGTLQSEAYAQFGFTPRKTQQIAQNLYVEGYTSYPRTSSQKLPESLGLPNILSQLSKHPKYKDKISQLEQPYKPHEGKKTDEAHPAIHPTGTLPKDISEDYQKIYDLITYRFISIFGKPAEMESIKVELDIGGEPFSFSRQRISKEGWLSLDPYQYKKVKNEEFPEIKEGQTTKAKVASEEKETKPPARYNQASIIRELEKRGLGTKSTRANIVSILYTRKYVEGKKIEVSQLGQQIINTLEKYSERITSEQMTREFETDISNIKENEITEATVIEDAKKELNGILDSIDDNIEDIGKELYGAYEQSRVVGKCGCGGNLIIISSPRGGKFVGCSNYPDCKKTYSLPAGANVLKTTCEKCGLPLISYGKPRQRACLDFECANGGQKSTNDVVGECPDCGKDLIKRMGRFGEFIGCTGFPKCRFTSSIDDFEKSKKESEKKD
(WP_074358334.1) MULTISPECIES: DNA topoisomerase I [Methanothermobacter wolfeii]	5	MHEVIICEKPKSSEKIARALFPDAERKKHGKVSYWEYEGDGKRVTVVSAVGHLYSLKPENPRAEHFFDLEWVPIHEIDKKKAYVRDYLNVIKKFASDADRYIHACDYDIEGTLIGFNALKYGCGDEALERARRMKFSTLTRDEIREAYENPIEIDYRQVDSGAARHILDFIFGVNISRSLMKSVKEATDRFIKLSAGRVQTPTLAILVEREKEIREFEPVPYWIIKALLEPDLVAESSRGRIFQKETVKEILEKCRGADASVKSVRIKETIRKPPVPFDLGTLQSEAYRAFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYDKILGELSKNSEFKKHIDKLKRPLKPHEGKKEDEAHPAIHPTGVIPTKLSKDDKRIYDLIVHRFISVFGDDAILETMKTELEIEDEKFTFSRRRVSRRGWMSSYPYTKIEDDVFPDLKEGDIINVREIVAEEKKTKPPARYNEASLIRELEKRGLGTKSTRADIIAKLYDRKYIEGRKIHVSPLGENLIDTLTKYCEKITNEELTRQFERELEEIMRGGVTRDRVIEEAIEEVKSILKDIDRNMKEIGRDLYRAYQDSRVVGECPECSKNLVIKYSPKNKSTFVGCSGYPDCRVVYSLPRGASILKTPCEKCGLPMISFGKPRQRACLNPKCGKKEIKGEEIVGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCSVDDCPDTD
(WP_048061102.1) DNA topoisomerase I [Methanothermobacter thermautotrophicus]	5	MHEVIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHLYSLRPRQSNEEHFFDLEWAPIHEIDKKKGYVKDYLNVIRKFAAGADRYIHACDYDIEGTLIGFNALKYGCGEEALRKTSRMKFSTLTREEIQRAYKNPIEVDYGQVDSGAARHILDFIFGVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRDFKPVPYWIIRAELGEGIIAESKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKPPVPFDLGTLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYEKILKNLAKNPRFGVHIERLRGPLKPHEGKKEDDAHPAIHPTGLLPSELSKDEKKVYDLIVHRFISVFGEDAILQTMKVELEIGEEEFSFSRKRVSKAGWMESYPYTKMEDEEFPEISGGDSLAVRSVSADERETKPPARYNEASLIRELERRGLGTKSTRADIIAKLYDRKYIEGKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELEDIMRGKISKDRVIDEAITEVRSILSDIEENLRDIGKELYRAYQDSRVVGECPACGGKLVIKYSPRNRSTFVGCSSYPDCRTVYSLPRGASVLKSLCEKCGLPMISYGRPRQRACLDPKCGKKKSEVEEVVGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCSVDEVPEG
(WP_013295046.1) DNA topoisomerase I [Methanothermobacter marburgensis str. Marburg]	5	MHEVIICEKPKSSEKIAGALFPDAERKKYRKVSYWEYSEGNKRVTIVSAVGHLYSLRPSKPGEEHFFDLEWAPLHEIDKKKNYVKDYLNVIKKFAAGADRYIHACDYDIEGTLIGFNAIRYGCGEDALQKTVRMKFSTLTREEIQSAYEKPIELDCGQVDSGAARHILDFIFGVNISRSLMKSVKEATNRFIKLSAGRVQTPTLAILVEREKEIREFEPVPYWIIQAELESGIVAESRRGKIFQRPLVDEVLERCSGSDASVRGVKVRDTVRKPPVPFDLGSLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYRKILDRLSEDPRFGAHIEGLSEPLKPHEGKKVDDAHPAIHPTGLLPSDLSSDERKIYELIVHRFISVFGEDAVLQTMRVDLEIGGEEFSFSRKRVSKRGWMDSYPYTRIEDEVFPDISEGDVMGVVGVSTLEKETKPPARYNEASLIRELEKRGLGTKSTRADIIAKLYDRKYIEGKKIRVSPLGENIIDTLTKYCEKITSEELTRQFERELEEIMEGKISRDRVVDEAIEEVKSILSDIERNMKDIGRDLYKAYQDSRVVGECPACGRNLVIKYSPRNKSTFVGCSGYPDCRTVYSLPRGASVLKSRCEKCGLPMISYGRPRQRACLDPSCGKKESKGEEIVGKCPECGSDLIKRSGRYGEFVGCKGFPRCRFTCSVDDVPAA
(WP_248564303.1) DNA topoisomerase I [Methanothermobacter tenebrarum]	5	MDEVIICEKPRSSEKIAKALFPKAKKKKYKKTYYWEYQGEDKRTIIIPAVGHLYTLKPKNPSDELFFDLEWAPIPEVDKKKRYIKNYIDAIDSLAKNADKYFHACDYDIEGTLIGYNVLKHICGEEALQKTLRMKFSTLTKNDIIKAYENPIELDYGQVDSGIARHVLDFIFGVNISRSLMRSVKESTNRFIKLSAGRVQTPALSILVDREKAIRKFKPEPYWVIKAILEDGIIALNQRGRIFQENEVEGVLGTCKGKDAIVEEVKINMITRMPPAPFNLGGLQAEAYKVFGLSPKRTQSIAQNLYLEGYISYPRTSSQKLPKTIGYEKILKGLSEDPRFHEKIAKLERPLKPYEGEKEDEAHPAIHPTGLLPEKLGKYERKVYELIVYRFISAFGGKALIESMNTKLNIGGEIFKFSRKRVAKKGWMEQYPYQKIEDEKFPEFEEGEKVPVKEIIAEENETKPPARYNEASLIKEMEKRGLGTKSTRADIISILYDRKYIEGKKIRVTPLGENIIDTLKRYCEKITSEELTRQFEEELKKIMKGKTSKDKVIKKAEEEIISIIEEIENNKEEIGKHLYKAYQKGRIVGECPECGGNLLIRYSGKTKSSFVGCSSFPECRIVYPLPKGARILKSKCEKCGLPLISYGRPRQRACLDPKCGKGEKGKMEVVGKCPECGNDLVKRSGRYGEFIGCKGFPKCRFTASLEEVKGKG

(WP_048084841.1) DNA topoisomerase I [Methanobacterium formicicum]

5

MHEVIVCEKPKASEKIAGAIPGKAVKKSYKKVPYYEIEKDGKKTTVLSAVGHLYSLSPLKKEKGRMFEVGWVPLYEKDKSKRYVKNYIDAIKKFSKNADRFVHACDYDIEGTLIGFNALKYACGEDSIDKAVRMKFSTLTKEDLLKAYNEPIDLDFNQVDSGEARHVLDFIFGVNISKDLTDSVMKATSRYIQLSAGRVQTPTLAILVEREKEIQSFIPEPYWLIKAKVEGRIIADHKKGKIFDKKVQEEILADCEGKDAQVSKISVKETPQLPPVPFDLGSLQSEAYGVFGFSPKKTQSIAQNLYAEGYTSYPRTSSQKLPPSIGYKKILGQLKKNAAFRKQIDKLKEPIKPREGKKTDEAHPAIHPTGLVPKGLGRDYQKLYELIVYRFISVFGENGILETMKTELDIGGQEFSFSRKRMAKMGWREHYPYRKVENDEFPALKEGDLLGAQAYSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKYVEGKKIAVNQLGERLIDTLKKYSEKITSEELTREFETKLGGIMKAEVKKEEIITEAKEEVSSILDDIDANKMKVGQELYSAYRESMIVGKCKCGGNLIMINSPKGGSFVGCTSYPDCKSTYSMPRGATVLKTKCEECGLPMISFGKPRQRACMDPKCGRDGEEPLQNEVVGVCPDCGKDLIKRRGRYGEFVGCSGFPRCRYTRSLEEKQEQTTKKSEKT

(WP_100909272.1) DNA topoisomerase I [Methanobacterium subterraneum]

5

MHEVIVCEKPKASEKIAGAIPGKAVKKSYKKVPYYEIEEGGKKTTVLSAVGHLYSLSPLKKEKGRMFEVGWVPLYEKDKSKKYVKNYIDAIKKFSKNADRFIHACDYDIEGTLIGFNALKYACGEDSIDNVVRMKFSTLTKEDLLRAYNEPIELDFNQVDSGEARHVLDFIFGVNISKNLTDSVMKATSRYIQLSAGRVQTPTLAILVEREKEIQSFIPEPYWLIKAKIEGNIIADHKKGKIFDKKVQDEILADCEGKDARVSKIGIKETPQLPPVPFDLGSLQSEAYGVFGFSPKKTQSIAQNLYAEGYTSYPRTSSQKLPPSIGYKKILGQLQKNAAFRKQIEKLKEPIKPREGKKTDEAHPAIHPTGLIPKGLGRDYQKLYELIVYRFISVFGENGLLETMKTQLDIGGQEFSFSRKRMAKMGWREHYPYRKVENDEFPALKEGDCLDARAYSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKYVEGQKISVNQLGEHLIDTLKKYSEKITSEELTREFETKLEGIMKAEVKKDEIITEAKSEVSSILDDIDANKMKIGEELYAAYRESMIVGKCKCGGNLIMINSQKGGSFVGCTSYPDCKSTYSMPRGATVLKTKCEECGLPMISFGKPRQRACMDPKCGRDGDEPLQNEVVGVCPDCGKDLIKRRGRYGEFVGCSGFPRCRYTRSLEEKQEPADEKS

(WP_071907366.1) DNA topoisomerase I [Methanobacterium congolense]

5

MHEVIICEKPKASEKISAALSKNAVKKSYKKVPYYEFEENGKKTTVLTAVGHLYSLSPKDRKQKKLFDVEWVPLYEKDKKKKYVKNYVDAIKKLSKNADRFVHACDYDIEGTLIGYNALKYACGEKSLDNAVRMKFSTLTEEDLIEAYEHPLEIDFKQVDSGIARHVLDFFFGVNMSKYLTDSVMKATKRYIQLSAGRVQTPTLSILVDREKEISKFVPVPYWLIKADLDVSGVDEIITADHKKGKIMERKDADAILSECEGKDALVSGVDLKKTKKTPPVPFDLGSLQSEAYAVFGFSPRKTQQIAQNLYTEGYTSYPRTSSQKLPKSIGYDKILKKLSYNSAFGKQISKLKKPYKPNEGKKTDEAHPAIHPTGLLPKEISTDYRKIYELITYRFISVFGEDALLETMKTRLEIGKEEFSFSKKRMAKMGWMEHYPFKKVENDEFPNITEGETIDVKEVRAEDKETKPPARYNQASLIRELEKRGLGTKSTRANIIDILYNRKYVEGKKIVVNELGEHLIDTLKKYSSKITSEELTREFEEKMEGIMEGNTKKGEVIKEAEVEVASILDDIESNKLKIGEELYAAYRESRVVGKCKCGHNLILIDSPRGGSFVGCSGYPDCKSTYSLPRGASILKTTCEKCGLPMISFGKPRQRACLDPKCGKEGKEPTNEVVGKCPECGSNLIKRSGRYGEFIGCSGFPKCRFTQSIEKGD

(WP_286242944.1) DNA topoisomerase I [Methanobacterium ferruginis]

5

MHEVIVCEKPKASEKIASAIPGKAVKKSYKRVPYYEIDEGNKKTTVLSAVGHLYSLSPLKKEKGRMFEVGWVPLYEKDKSKKYVKNYIDAIKKFSKDADRFVHACDYDIEGTLIGFNALKYACGPESIDNAVRMKFSTLTKEDLLKAYNEPIDLDFNQVDSGEARHVLDFLFGVNISKDLTDSVMKATSRYIQLSAGRVQTPTLAILVEREKEIQSFIPEPYWLIKAEIEGNIIADHKKGKIFDKKVEEEILADCDGKDARVSQIKVKETPQLPPVPFDLGALQSEAYGVFGFSPKKTQSIAQNLYAEGYTSYPRTSSQKLPPSIGYKKILGKLKKNAAFKKQIEKLKEPIKPREGKKTDEAHPAIHPTGLVPKGLGRDYQKLYELIVYRFISVFGENGILETMKTELDIGGQPFSFSRKRMAKMGWREHYPYRKVENDEFPALKEGDSLGARAYSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKYVEGKKITVNQLGEHLIDTLKKYSEKITSEELTREFETKLEGIMKAEVKKDEIIAEAKAEVSSILDDIDANKIKIGEELYASYRESMIVGKCKCGGNLIMINSPKGGSFVGCTSYPDCKSTYSMPRGATVLKTKCEKCGLPMISFGKPRQRACMDPKCGREGEEPTQNEVVGVCPECGKDLIKRRGRYGEFVGCSGFPRCRYTRSLEEKEDQKSEKT

(WP_013826367.1) DNA topoisomerase I [Methanobacterium paludis]

5

MHEVIICEKPKAAEKISSALSKGAAKKHYKKVPYYEFEENGKKTTVLTAVGHLYSLAPKDKKQDKLFDVEWVPLYEKDKKKKYVKNYIDAIKKLSKDADTFVHACDYDIEGTLIGYNALKYACGDESLKNVMRMKFSTLTDEDILKAYKKPMELDFKQVDSGIARHVLDFFFGVNMSKHLTDSVMKATKRYIQLSAGRVQTPTLSILVDREKEIKEFIPVPYWLIKADLDVTGVKEGITADHKKGKILEKKDADAILVECKGKDAVITEVNLRKTTKTPPFPFDLGSLQSEAYGVFGFSPRKTQQIAQNLYTEGYTSYPRTSSQKLPKSIGYDKILKKLSYSSAFGNHVAQLKKPYKPNEGKKTDEAHPAIHPTGVLPKELSTDYRKLYELIVYRFISVFGENATLETMKTTLTIGKEEFNFSRKRMSKMGWMGHYPFRKIEEDYFPTMNKGETLNVKEVRAEDKETKPPARYNQASLIRELEKRGLGTKSTRANIIDILFSRKYVEGKKITVNKLGEQLIDTLRKYSKKITSEELTREFETKLEGIMEGKDKKDKIIDEARVEVSSILDDIEKNKLKIGEELYKSYRESRVVGKCKCGKNLILIDSPRGSTFVGCSGYPECKSTYSMPRGATVLKTTCEECGLPMISFGKPRQRACLDPKCGKDGREPTNEVVGKCPDCGSDLIKRSGRYGEFIGCSGFPKCRFTKSIDDDGGKTAAKTTGAPKKTVAKKAATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKSATKKNAKKTK

(WP_013644136.1) DNA topoisomerase I [Methanobacterium lacus]

5

MHEVIICEKPKASEKIASALSKNSTKKKYKKVSYYEFEENGNKTTVLTAVGHLYSLAPKNKNKGRLFDVEWVPLYAKDKKKKYVKDYVDAIKKFSKNADRFVHACDYDIEGTLIGYNALKYACGENSLDNAVRMKFSTLTNEDITAAYEKPLNIDFNQVDSGIARHVLDFLFGVNISKSLTESVMETTKRYIQLSAGRVQTPTLAILVEREKEIQKFIPEPYWMIKADLDVPGIDELVTADHKAGKIFDKNVADEIFADCDGKNAVVDGIDVRETVKAPPFPFDLGSLQSEAYAVFGFSPKKTQQIAQNLYTEGFTSYPRTSSQKLPKSIGVDKILKKLSYSGSFRNQIAKLKKPYKPNEGKKTDAAHPAIHPTGVIPKELSTDDRKLYELITYRFISVFGENGLLESMKTSLKIGDQDFSFSRKRMAKLGWMELTPFKKAENDSFPTISKDDELLVEAVRSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKFVEGKKIKVNELGEHLIDTLKEYSNKITSEEMTREFETRLEDIIEGSVNKDNIIEEAKIELTSILDDIDKNKAVIGEQLYKSYRESRVVGKCKCGGNLVLIDSPRSNSFVGCSGYPECKSTFSLPRGATILKTTCEECGLPMISFGKPRQRACLDPKCGKDGQEPSNEIVGVCPDCGKDLIKRSGRYGEFIGCSAFPKCRYTRSLDEPAPEVSGVPNSTNKPIKAAAKKSGKTAVKKATAKKSGKTAVKKATPKKSSRKVTKTRKVSKRSS

(WP_286473639.1) DNA topoisomerase I [Methanobacterium aridiramus]

5

MHEVIICEKPKAAEKISQALPGYAEKKNYKRVPYYEIEENGKKTTILAAVGHLYSLSPLKKENGRIFEVEWVPLHTKDKSKRYVKNYIDAIVKFSKDADKFIHACDYDIEGTLIGFNALKYACGDKSVEQAVRMKFSTLTDEDLLEAYHNPIDLDFHQVDSGIARHVLDFLFGVNISKYLTDSVMAATSRYIQLSAGRVQTPTLSILVDREKQIKEFKPEPYWLIKADLGLGIIADHKQGKIFDKKKTEDILAHCQGEDAVVDKISLKETAQSPPVPFDLGTLQSEAYSVFGFSPKKTQSIAQNLYTEGYTSYPRTSSQKLPASIGYQKILGKLSKNSSFAKHIKKLKKPLKPREGKKTDAAHPSIHPTGVLPNKLGRDYQKLYELIVHRFISVFGQNAILEAMKTDLKIGDEDFTFSRKRMAKMGWKEHYPFRKVENDEFPSLKEGEKLEAKVDSEEKETKPPARYNQASLIRELEKRGLGTKSTRANIISILYDRKYVEGKKITVNQLGEHLIDTLKEYSEKITSEELTREFETRMEGIMSGETDKDDIIQQARVEVSSILDDIEKNKLKIGEQLYQAYRESMVVGSCKCGGNLITINSPRGGTFVGCSAYPECKSTYSLPQGANVLKATCEKCGLPMISFGKPRQRACLDPKCGREGEEPPKNEVVGVCPDCGKDLLKRLGRYGEFVGCSGFPRCRYTRSLEEDEEKVQEKS

(WP_211532577.1) DNA topoisomerase I [Methanobacterium alkalithermotolerans]

5

MHEVIICEKPKSSEKIAQALSPHAEKKTYKKVAYWEFEEEGKKTTVLSAVGHLYSLKPLNSKNEHFFDLEWIPLYDIDKKKSYVKDYVNAIKKFGKGADIFIHACDYDIEGTLIGYNALKYICGDKSVENALRMKFSTLTKEDVLNAYHKPIDLDFNQVDSGIARHVLDFIFGVNISKALMKSVRESTSRFIKLSAGRVQTPTLSILVDREKEIREFVPVPYWMIKALLEEGIVADNKKGKIWDKKEAEAVLSNCKGNDAVVDHIKLLNTTKKPPFPFDLGSLQSEAYGVFGFSPKRTQQIAQNLYTEGYTSYPRTSSQKLPKSIGYEGILEKLSKDSAFKKQIKKLPTPLKPNEGKKKDEAHPSIHPTGVLPKKLSTDDRKLYELIVYRFISVFGEDATLETMKTELKIGEEDFLFRRKRISYMGWLEHYPFRKVENDEFPDIKKGDRLKVKKIRSEEKETKPPARYNEASLIRELEKRGLGTKSTRADIIAILYDRKYIYGKQITVNQLGENIIDTLREYSPQITSEELTRQFENELQEIMAAEITKEKVIDDAKKEVISILEDVEKSKLKIGQKIYDAYQESRIVGECKCKGNLVLKYSPRNKSTFVGCSNYPDCKATYSLPRGASVLKTTCEKCSLPLISFGKPRQRACLDPKCGQDGKETKPEVVGKCPECGKQLLKRSGRYGEFIGCSGFPKCRFTQSLEEKEANKSG

(WP_011954063.1) MULTISPECIES: DNA topoisomerase I [Methanobrevibacter smithii ATCC 35061]

5

MNEVIICEKPKSAEKIAKALSSKAKKNVFNKKVKYWTLERDGKDITVLSAVGHLYSLTPDNPKDKVYFDLHWAPLFEIDKKYKNYTKDYVRAIKKYAKDADSYIHACDYDIEGTLIGYHALKYGCGDDALKKSSRMKFSTLTKKDIVEAYENRIPIDRHQVDSGVARHILDFYFGVNISKALMKSVSAAKKRFLKLSAGRVQTPTLSILVDREKEIKKFVPKPYWLIKALLDGEIEADHVDGKIFDKTRAEEIFSNCENSDAAVDKIKYSNSTTKPPVPFNLGGLQSEAYNVFGFSPKKTQTIAQSLYTAGYTSYPRTSSQKLPESLDFKSIFLQLSKNSEFRTHISALPAKLKPNEGKKEDAAHPAIHPTGILPDKLDKDELKIYELIVYRFISVFFEAATFETMSTTLDIGGEKFKFRRRRVTHKGWLEHYPFKKIDNEEFPDVKEGDSIIVKEIVSEEKETKPPARYNQASLIKELEKRELGTKATRADIIDKLYDRKYITGNKIEVNQLGENIIDTLSEYCSNLTSEELTRDFENKLEGIDNDKATRESVVAEGEKEVKVILGDIDKNKVKIGSQIYDAYQESNIVGKCKCGGNLVKKYSPKNKSTFVGCSNYPDCKATYSVPKGANFLKKTCKTCGLPIISFGKPRQHACLDPNCGKENTKPREMKVVGVCPSCGKELIKRSGRYGEFVGCRGFPKCRFTCSLDELKDKVQ

(WP_012955193.1) DNA topoisomerase I [Methanobrevibacter ruminantium M1]

5

MHEVIISEKPKSAEKIAKALSPNAQKKKYNRKINYWEFEENGKKTTVLSAVGHLYSLTSASSRDRLGFDLTWVPAYEVEKQKYTRDYINAIKKLSKGADKFVHACDYDVEGTLIGYNALKYACGNNAEAKASRMKFSTLTKKDIVEAYNTMRDIDIRQVDHGIARHMLDYYYGMNISSALMKAVRASSSRFISLSAGRVQTPTLSILVDREKEIQSFVPEPYWMIKAKSDYDIIADHVEGKIFDEERAKKIYADCQGADADVTSVKVTESIRKPPIPFNLGGLQSEAHTVFGFSPKRTQVAAQNLYVGGYTSYPRTSSQKLPESLDFKNIFAGLAKDPEFKKHIFDLPAKLKPNEGKKTDAAHPAIHPTGVLPSNLSADEAKIYSLIVYRFISVFSENSKLETMKVNLKVADEKFTFSRKRVSYEGWLKHYPFKKQENDAFPPINKGDQLKIHKILVEEKETKPPARYNEASLIKELEKRELGTKATRADIVAKLYDRKYIEGKKIEVKPLGINIIDTLNEYCKDLTSEELTREFERELEGIDTDKYTKEQILENGEKEVKTILAEINQNKKQIGEKLYGAYQETNVVGECSCGGKLIKRYSPRTKNTFVGCSNFPKCKVTYSLPKGANMLKKTCPTCGLPMISIKKASGKGRDHVCLDSNCGKDVSRRQAPEVVGKCPECGKDLLKRSGRYGEFVGCSGFPRCRFTCSVDELNNLGKDKNKEDVKENKGVSKKIVRSEAK

(WP_409198101.1) DNA topoisomerase I [Methanobrevibacter acididurans]

5

MHEIIICEKPKAAEKIAQAISPNVKKRKYNKKVSYWEIEEENKKITVLSAVGHLYSLTPVNPKSKVFFDLEWAPLYEIDKTKKYTRDYVYAIKKFSKDADKFIHACDYDIEGTLIGYNALKYACGQNTTANISRMKFSTLTKTDILDAYNNMIDLDLHQVESGSARHVLDFYFGVNISKSLMHSVRTAKKRFLKLSAGRVQTPTLSILVDREKQIKKFIPKPYWLIKALLNGEIIADHEDGKIFDKKRAEEIFDKCQNQNALVDEVKKTETIRKPPVPFNLGGLQSEAYGVFGFSPKKTQMIAQNLYTGGFTSYPRTSSQKLPKSLEYKKIFMQLSKNAEFKKHIQDLPSELKPNEGKKKDAAHPAIHPTGVLPDKLSKDELKIYELIVYRFISVFCENSKLESVKTDLLIADEKFNFKRKRVSYLGWLAHYPFKKIENENFLDIKKGDIIKVEKICSEQKETKPPARYNEASLIKELEKRELGTKATRADIIAKLYDRKYISGKKIEVNQLGENLIDTLKEYCEDLTSEDLTRDFEKRLEGISNDKTTQEAVVNDAEKEVKAILGDINKNEADIGDKLYDAYQQSRIVGECSCGGNLVMKYSPRNKSHFVGCSNYPECEITYSLPKGATFLKKTCPKCGLPIISFGKPRQHACLDPNCGKDNTKRHVVKVVGVCPDCGKDLVKRSGRYGDFVGCKSFPKCRFTCSLEELKDLESKSKK

(WP_067145196.1) DNA topoisomerase I [Methanobrevibacter olleyae]

5

MHEVIISEKPKSAEKIAKALSSKAQKKKYARKINYWEFEEDGKKTTVLSAVGHLYSLTSASSSDRLGFDLTWVPAYEVDKNSAYVRDYVYAIKKLSRDADKFVHACDYDIEGTLIGYNALKYACGNNAEAKASRMKFSTLTKKDIVEAYNNMIDIDPHQVDSGIARHMLDYYFGMNISSALMKAVLSSSSSRISLSAGRVQTPTLSILVDREKEIQAFVPEPYWQIKAKSDFDIIANHVEDKIFDEKRAKRIFDECQGADATVTNVNVRETIRKPPIPFNLGGLQSEAHTVFGFSPKRTQVAAQNLYVGGYTSYPRTSSQKLPESLGFKEIFAGLSKDEEFKKHVFDLPSKLKPNEGKKEDAAHPAIHPTGALPSNLSPDEEKIYRLIVYRFISVFSEDSKLETMKVNLNVNNEKFIFSRKRVSYEGWLKHYPFKKQEADEFPPLKKGDFLKIHKIISEEKETKPPARYNEASLIKELEKRELGTKATRADIIAKLYDRKYIDGKKIEVKPLGVHIIDTLKQYCKNLTSEELTREFEKELDSLSADKITKEEILANGEKEVESILKDINNNQKEIGSKLYESYQQSNIVGDCSCGGKLVKKYSRRTKQSFIGCSKFPQCRNTYSLPKNTNILKSKCPTCGLPMISIKKKGQKGREHVCLDPNCGKDLSKRRAPEVVGKCPECGKDLLKRSGRYGDFVGCSGFPKCRFTCNVKDLENLEKEKTDSKENKSKQMVKVKSK

(WP_011405969.1) MULTISPECIES: DNA topoisomerase I [Methanosphaera stadtmanae DSM 3091]

5

MSELIICEKPKVAEKVAKALSDSPVKNSYKRVPYYEFTNGNGTKITVLSAVGHLFSLKAKNKKDKRLFDVEWVPLSETDKSKKYVKNYIDTIKKFSKDADRFIHACDYDTEGTLIGFNALRYICGEDSIDKSFRMKFSALTKKDLIESYSNAYPLKEDKSWVDSGETRHVLDFLFGVNISKSMTDSVLNVTNRYVQLSAGRVQTPTLAILTEREKEIQKFIPEPYWLIKAKLQKSIVADHKKGKIFDKKEVDAILKNCKGKDATVEKITNRKTKKDLPVPFELGTLQSEAYAQFGFTPRKTQQIAQNLYVEGYTSYPRTSSQKLPESLGLPNILSQLSKHPKYKDKISQLEQPYKPHEGKKTDEAHPAIHPTGTLPKDISEDYQKIYDLITYRFISIFGKPAEMESIKVELDIGGEPFSFSRQRISKEGWLSLDPYQYKKVKNEEFPEIKEGQTTKAKVASEEKETKPPARYNQASIIRELEKRGLGTKSTRANIVSILYTRKYVEGKKIEVSQLGQQIINTLEKYSERITSEQMTREFETDISNIKENEITEATVIEDAKKELNGILDSIDDNIEDIGKELYGAYEQSRVVGKCGCGGNLIIISSPRGGKFVGCSNYPDCKKTYSLPAGANVLKTTCEKCGLPLISYGKPRQRACLDFECANGGQKSTNDVVGECPDCGKDLIKRMGRFGEFIGCTGFPKCRFTSSIDDFEKSKKESEKKD

(WP_074358334.1) MULTISPECIES: DNA topoisomerase I [Methanothermobacter wolfeii]

5

MHEVIICEKPKSSEKIARALFPDAERKKHGKVSYWEYEGDGKRVTVVSAVGHLYSLKPENPRAEHFFDLEWVPIHEIDKKKAYVRDYLNVIKKFASDADRYIHACDYDIEGTLIGFNALKYGCGDEALERARRMKFSTLTRDEIREAYENPIEIDYRQVDSGAARHILDFIFGVNISRSLMKSVKEATDRFIKLSAGRVQTPTLAILVEREKEIREFEPVPYWIIKALLEPDLVAESSRGRIFQKETVKEILEKCRGADASVKSVRIKETIRKPPVPFDLGTLQSEAYRAFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYDKILGELSKNSEFKKHIDKLKRPLKPHEGKKEDEAHPAIHPTGVIPTKLSKDDKRIYDLIVHRFISVFGDDAILETMKTELEIEDEKFTFSRRRVSRRGWMSSYPYTKIEDDVFPDLKEGDIINVREIVAEEKKTKPPARYNEASLIRELEKRGLGTKSTRADIIAKLYDRKYIEGRKIHVSPLGENLIDTLTKYCEKITNEELTRQFERELEEIMRGGVTRDRVIEEAIEEVKSILKDIDRNMKEIGRDLYRAYQDSRVVGECPECSKNLVIKYSPKNKSTFVGCSGYPDCRVVYSLPRGASILKTPCEKCGLPMISFGKPRQRACLNPKCGKKEIKGEEIVGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCSVDDCPDTD

(WP_048061102.1) DNA topoisomerase I [Methanothermobacter thermautotrophicus]

5

MHEVIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHLYSLRPRQSNEEHFFDLEWAPIHEIDKKKGYVKDYLNVIRKFAAGADRYIHACDYDIEGTLIGFNALKYGCGEEALRKTSRMKFSTLTREEIQRAYKNPIEVDYGQVDSGAARHILDFIFGVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRDFKPVPYWIIRAELGEGIIAESKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKPPVPFDLGTLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYEKILKNLAKNPRFGVHIERLRGPLKPHEGKKEDDAHPAIHPTGLLPSELSKDEKKVYDLIVHRFISVFGEDAILQTMKVELEIGEEEFSFSRKRVSKAGWMESYPYTKMEDEEFPEISGGDSLAVRSVSADERETKPPARYNEASLIRELERRGLGTKSTRADIIAKLYDRKYIEGKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELEDIMRGKISKDRVIDEAITEVRSILSDIEENLRDIGKELYRAYQDSRVVGECPACGGKLVIKYSPRNRSTFVGCSSYPDCRTVYSLPRGASVLKSLCEKCGLPMISYGRPRQRACLDPKCGKKKSEVEEVVGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCSVDEVPEG

(WP_013295046.1) DNA topoisomerase I [Methanothermobacter marburgensis str. Marburg]

5

MHEVIICEKPKSSEKIAGALFPDAERKKYRKVSYWEYSEGNKRVTIVSAVGHLYSLRPSKPGEEHFFDLEWAPLHEIDKKKNYVKDYLNVIKKFAAGADRYIHACDYDIEGTLIGFNAIRYGCGEDALQKTVRMKFSTLTREEIQSAYEKPIELDCGQVDSGAARHILDFIFGVNISRSLMKSVKEATNRFIKLSAGRVQTPTLAILVEREKEIREFEPVPYWIIQAELESGIVAESRRGKIFQRPLVDEVLERCSGSDASVRGVKVRDTVRKPPVPFDLGSLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYRKILDRLSEDPRFGAHIEGLSEPLKPHEGKKVDDAHPAIHPTGLLPSDLSSDERKIYELIVHRFISVFGEDAVLQTMRVDLEIGGEEFSFSRKRVSKRGWMDSYPYTRIEDEVFPDISEGDVMGVVGVSTLEKETKPPARYNEASLIRELEKRGLGTKSTRADIIAKLYDRKYIEGKKIRVSPLGENIIDTLTKYCEKITSEELTRQFERELEEIMEGKISRDRVVDEAIEEVKSILSDIERNMKDIGRDLYKAYQDSRVVGECPACGRNLVIKYSPRNKSTFVGCSGYPDCRTVYSLPRGASVLKSRCEKCGLPMISYGRPRQRACLDPSCGKKESKGEEIVGKCPECGSDLIKRSGRYGEFVGCKGFPRCRFTCSVDDVPAA

(WP_248564303.1) DNA topoisomerase I [Methanothermobacter tenebrarum]

5

MDEVIICEKPRSSEKIAKALFPKAKKKKYKKTYYWEYQGEDKRTIIIPAVGHLYTLKPKNPSDELFFDLEWAPIPEVDKKKRYIKNYIDAIDSLAKNADKYFHACDYDIEGTLIGYNVLKHICGEEALQKTLRMKFSTLTKNDIIKAYENPIELDYGQVDSGIARHVLDFIFGVNISRSLMRSVKESTNRFIKLSAGRVQTPALSILVDREKAIRKFKPEPYWVIKAILEDGIIALNQRGRIFQENEVEGVLGTCKGKDAIVEEVKINMITRMPPAPFNLGGLQAEAYKVFGLSPKRTQSIAQNLYLEGYISYPRTSSQKLPKTIGYEKILKGLSEDPRFHEKIAKLERPLKPYEGEKEDEAHPAIHPTGLLPEKLGKYERKVYELIVYRFISAFGGKALIESMNTKLNIGGEIFKFSRKRVAKKGWMEQYPYQKIEDEKFPEFEEGEKVPVKEIIAEENETKPPARYNEASLIKEMEKRGLGTKSTRADIISILYDRKYIEGKKIRVTPLGENIIDTLKRYCEKITSEELTRQFEEELKKIMKGKTSKDKVIKKAEEEIISIIEEIENNKEEIGKHLYKAYQKGRIVGECPECGGNLLIRYSGKTKSSFVGCSSFPECRIVYPLPKGARILKSKCEKCGLPLISYGRPRQRACLDPKCGKGEKGKMEVVGKCPECGNDLVKRSGRYGEFIGCKGFPKCRFTASLEEVKGKG

Name	Methanobacteriales
Rank	order
Topoisomerases	17

Lineage	Archaea > Methanobacteriati > Methanobacteriota > Methanomada group > Methanobacteria > Methanobacteriales
Sub-taxa

Taxon : Methanobacteriales