Toggle navigation
TopoIBase
Data
Taxonomy and VLD families
Downloads
My selection
Upload to selection
Selection 1
Selection 2
Selection 3
Tools
Blast
MUSCLE
VLD
About
How to use
Acknowledgements and references
Contact
Tests
Search more
Download
fasta
tsv
Download
Blast
Muscle
VLD
Add to selection
Selection 1
Selection 2
Selection 3
All selections
Taxon : Proteobacteria
Informations
Name
Proteobacteria
Rank
phylum
# topoisomerases
675
Lineage and sub-taxa
Lineage
Bacteria
>
Proteobacteria
Sub-taxa
Topoisomerases
Select all
Name
Family
Sequence
(170) DNA topoisomerase 1 [Sinorhizobium fredii NGR234]
1
MNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLILATDPDREGEAISWHVLDLLKKKKVIGDKPVKRVVFNAITKKAVLDAMADPRDIDISLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLQPKAVGNGEEANRLKALLDGASYVVESVEAKPVKRNPGPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDVGGETVGLITYMRTDGVQMAPEAIDAARRAIGSQFGTRYLPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDEVRRFLDGDMLKLYDLIWKRGIASQMASAEIERTTAEIAADNGGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDESGRLPEINARENLAKQKINATQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATISTLVDRDYVEIDKRKLMPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLREFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRTCQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSNGDAEAAVSNEPQSLGKDPHTGEEITLRSGRFGPYVQRGDGKDAKRASLPKGWTPATIDHEKALALLSLPRDIGKHPETGKMISTGIGRYGPFVLHDGTYANLESVEDVFSIGLNRAVSALADKQSKGAGGGRTAAAALKELGEHPDGGVMTVRDGRFGPYVNWGKVNATLPKGKDPQSVTVEEALALIAERAAKGGVSKGKAGNGKAARGRSSTAATKSTAAKAEKPKAAAKAKSKTAAKAKKG
(1016) DNA topoisomerase 3 [Shigella flexneri]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIA
(1727) DNA topoisomerase 1 [Shigella flexneri]
9
MGKALVIVESPAKAKTINKYLGCDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(1015) DNA topoisomerase 3 [Shigella flexneri]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIA
(1033) DNA topoisomerase 1 [Shigella flexneri]
9
MGKALVIVESPAKAKTINKYLGCDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVHKDHALTLVELTPVHHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGRATGWSAFYVDGKWVEGKK
(1211) DNA topoisomerase 3 [Saccharophagus degradans 2-40]
10
MRLFIAEKPSLGRAIADVLPKPHSRGDGFIRCGNGDVVSWCIGHLLEQAEPEAYNPVFKQWRLEHLPIIPDQWQLKPKSKTRKQLTALRKLVKEATCIVHAGDPDREGQLLVDQVIDFLGVKGAKRESVQRCLINDLNPAAVKRSLDTLRSNKEFIPLATSALARSRADWLYGINMTRAYTLQGRKVGYEGLLSVGRVQTPILGMVVERDRAIEEFVSKPFYEVLAHLTTLTGEPTAFTAKWLPSEACEPYMDEDGRVLSKKLAQNVIARITGENGVVEKVDKKAKAQAAPLPYNLSSLQIDAAKRFGFAAQKVLDICQNLYEKHKLITYPRSDSRYLPADHWHQANDVLQAISANVAELVQSVSGANSKLKSKAWNDAKVDAHHAIIPTAKKVSFSSITSEEQKVYSLIARQYVCQFYPKWEYSDTVIHLKIAGGQFVSKARLTHKQGWKVLFERKGGEPNPKDDDEFPSLTLPDLHVGQSVACRQGELLEKQTQPPKYFTDASLLAAMTGIARYVTDPDIKKILKDTDGLGTEATRAGIIELLFKRNFLVRKGKQIHSTPAARGLVAALPSSATTPDMTAQWELVLNAISIREAQYTTFMKPLVASLQTLIAESQRNLPIGLKGVAAKPKAFKRRRKVKAKSV
(543) DNA topoisomerase 1 [Saccharophagus degradans 2-40]
9
MEKSLVIVESPAKAKTINKYLGNKFVVKSSVGHIRDLPTSGGAKSTVDPKERAKQAALTRKMSPEEKAIHREKKSREQLINRMGINPEKNWEARYEILPGKEKVVEELKKLAEEADTIYLATDLDREGEAIAWHLQETIGGDPDRYRRVVFNEITKTAIQKAFEKPSMLDLNRVNAQQARRFLDRVVGYMVSPLLWEKIARGLSAGRVQSVAVRLVAEREREIRAFIPEEYWDIAAQLDTPKGERAGFDVKKYQGNVFRPVNEKEAMEAVERLKASAFKVTSREDKPTQSKPTAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSAEAVETCRGFILDTFGEKYLPEAPISYSSKEGAQEAHEAIRPSDVTRRPDSLTDMERDAQRLYTLIWNQFVACQMTPAQFTSSNIVVTASDYELRARGRVIRFDGFLRVMPAIAKKDEDKILPDVKVGETLNLHQLDPSQHFTKPTARYTEASLVKELEKQGIGRPSTYAAIISTIQDRGYVHVENRRFYADKMGDIVTERLTESFSDLMDYSFTAKMEESLDVVAEGKKDWLSLLNNFYDDFMQKLDAAKAADTGMRRNEPVETNIECTNCGRNMQIRTGTTGVFLGCSGYNLPPKERCKNTMNLVAGEEAVNIDEDDEAESKQLRQKRRCKICNTAMDSYLLDETRKLHICGNNPDCSGYEVEAGSFKIKGYEGPVIECDKCGQDMQLKSGRFGKYFGCTSESCSNTRKLLRNGEAAPPKMDPVKMPELKCEKVDDTYVLRDGASGIFLAASQFPKNRETRAPLVKELLPHKDEIDPKYDFLMKAPLQDNNGLDTIVRYSRKTKEQYVQTEVDGKATGWKAFYEGGKWVISDEQKPKKPAKKAATKTKAKPKAKAKAKKDE
(1706) DNA topoisomerase [Burkholderia cenocepacia J2315]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDDFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPQAIRDGFANLRSDSDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFIPRDYWEVKAEFACAGGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLSTVQSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEFRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIPEVEELLQKKEIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMGKLLADGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDAETVTEGAEEKPAPARKTAARKTTARKTGS
(1605) DNA topoisomerase 1 [Geobacter sulfurreducens PCA]
1
MSQHLVIVESPAKAKTIEKFLGPDYKVLASYGHVRALPSKQGSVDVEHDFEPRYAVLPESKRHIDAIKKELKASDSLLLATDPDREGEAISWHLLAALGVKPEKPPVPVRRVVFHEITKDAIVHAVENPRDISQDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFQSQEYWTIGAELAKEGGQKCTANLVEAEGKKLDKFDIPDQAAADRLVKALENATFTVDKVTKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMATAQKLYEGVAIDEGLVGLITYMRTDSVVLSNQALQEAHQVITSLYGPEYALAKPRFYKNKAKNAQEAHEAVRPTSIARTPAELKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGKGYRFRAAGTVIRFPGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLLKLLPEQHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLLERKYARLDSKRFIPEDVGMVVNDLLTNHFTTYVDYNFTATLEEELDQVSRGEKRWKPLLREFWEPFQGLLKQKEGEVSKADLTTEATDEACPECGKPLVVKLGKRGKFIACSGYKEGCTYTRNIDQGEGREQAEPVLSEEKCDKCGSPMLIKDGRFGKYLACSAYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPGPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
(1126) DNA topoisomerase 3 [Vibrio cholerae O1 biovar El Tor str. N16961]
10
MTRLFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKKWNMADLPIIPEQWQLRPRKSSSQQLTVVRKLLKEATQIIHAGDPDREGQLLVDEVIDYCKVPKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSALARSRADWLYGMNMSRAYTLLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFTLDALIPYQNGTEYFDIRARWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESEQDQTKQAAPLPYSLSALQIDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPKEHLAQAPDVVAAIANNAQEMVTAVNDADLSLRSKAWNDSKVDAHHAIIPTPKKASVNALSGHEMKVYQLIARQYLMQFYPAAIYAEAKLVFNIAGGIFIAKGRQLLSAGWKVLTGQQDEQEECVDKVPPLPVGIVLQCREGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKILRETDGLGTEATRAGILDTLFKRGLLQRDNKLIKSTPAGRGLIHALPSEATYPDMTAHWEHQLQAIAEKGQAYQPFMQTLQGRLEQLIEQVQVAPVPVSLQALPAVSKPAFKRTRRAPKSKARTYKA
(1611) DNA topoisomerase 1 [Vibrio cholerae O1 biovar El Tor str. N16961]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKASTTDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQPNVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHIVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECDKCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVLRDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFSRKEKEHYVRTETEGKPSGWMAVYQEGKWLVTDKRKNAK
(442) DNA topoisomerase 3 [Photorhabdus luminescens subsp. laumondii TTO1]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGDNQFVTWCIGHLLEQAEPDAYDNRFARWSLVDLPIIPEKWQLKPRPSVEKQLNIIQTLLEKADEIVHAGDPDREGQLLVDEVLDFLKLDAVRRKNVRRCLISDLNPQAVTRAVDRLRDNRDFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPILGLVVRRDEEIEHFVPKDFFEVKAHIVTPKDERFIAIWQPSESCIDFLDEEGRLIHRPLADHIVTRITGQPAYVISYQDKRESEVAPLPFSLSSLQIEAAKRFGLNAQQVLDICQRLYETHKLITYPRSDCRYLPDEHFAGRHAVLNAISIHATKLLPQELLEIDRKNRCWDDKKVDAHHAIIPTARSSHINLTDSEANIYGLIARQYLMQFFPDAIFRKCVIELEIAGGKFIAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKGDELLCERGEVVERQTQPPKPFTDATILSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKREFLYKKGRHIHATPAGRALIHVLPDMAALPDMTAHWESRLTQISEKQFRYQDFMGPLEETLQQLIWQAKQNRNLTAFRDLPPLPVKDKKGKKIKAPKNTKRAAP
(1735) DNA topoisomerase 1 [Photorhabdus luminescens subsp. laumondii TTO1]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSASQKSSSSSTDKSKKKVKKDEKAVLVNRMGVDPYRGWEANYQILPGKEKVVAELKSLAEKVDHVYLATDLDREGEAIAWHLREVIGGDGDRFSRVVFNEITKNAIKQAFDNPGELNIHRINAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPVEYWQLHADLLAKGEISLHMEVTHQQGKPFKPVNSEQTQAAVSLLEKARYKVLDREDRPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALDMVRDYISDNFGDKYLPEAANTYSSKENSQEAHEAIRPSSVDIVAEQLKDMDVDAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFELRAKGRTLRFDGWTKVMPVLRKGDEDHTLPVVEIGTELDLQQLIPSQHFTKPPARYSEASLVKELEKRSIGRPSTYASIISTIQERGYVRVESRRFYSEKMGEIVTDRLEENFNELMSYDFTARMEDQLDQVASNKVEWKGVLDEFFTDFSEQLDVANKEPEEGGMRPNPMVITSIECPTCQRSMGIRTATTGVFLGCSGYALSPKERCKQTINLIPENEILNVLEGDEAETNALRARRRCKKCGTAMDSYLIDSQRKLHVCGNNPACDSYEVEEGEFRIKGYDGPVIECDKCGAEMHLKMGRFGKYMGCTNETCKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKERLPEKLRYLADAPVVDAEGNKTVIRFSRKTKQQYASSEKNGKATGWSVFYVDGKWVEKDKK
(564) DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family [Myxococcus xanthus DK 1622]
7
MLAEKPSVARDIARVLGANERGEGWLRGNGYVVTWAIGHLVGLAQPHEIRADWKKWSRALLPMLPADWPLVVSKETRSQFEVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKCRKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSRADWLVGMNLSRLYTLAHGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALYKGTWFRSGPDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMAPPLLYDLTELQRHANRLHGFSAQRTLEVAQALYEKHKLLSYPRTASRHLSRTVADTLPEVVNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVRLSPDEQRVYDLVCRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPRLKSEGRKGEDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAMESAGRALDEKELADAMRETGLGTPATRAAIIEVLLDREYLRRRGKVMEATEKGIHLIQVVHPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAPQRPPRNEVLGAPPGAGWGQGGAAQVASEGAAAAHGAGAGARGPGGQGAFAESSAERFGDASAGGAGRGRQGAFTEASAERFADAAPGVQGQGRPGALSEASEPLFGTRRSRTSGSVGRSEPHGEPLSSTMSPGGGAASRLPRADGTGWNAGAWENTGAARAPVNRARTPASAASTGQRPERVRRAPTAPEALRPLLKEAFGFSDFRPYQEAVCRAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQVARLQSLGFAADRIHSGRDRAMSRQVCADYLEDRLDFLFIAPERLGVPGFVEFLARRTPALIAVDEAHCISQWGHDFRPDYRLLGARLPLLRPAPVVALTATATPDVQRDIVQQLGLQGPGGKARTFIHGFRRTNIAIEVRELNPGARGDAIQGLLEDEENRPAIVYAATRKHAEQLADQLAGEFPAAAYHAGLQPSERDRVQAEFLRGSLEVIVATTAFGMGIDKADVRTVIHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYIDRRTHEFFHRRDYPEAYVLERLFKSTAPQLEPKAVLQGRVRGDPEVFDKALEQLWIHGGVVMTPDETVMRGKPGWSASYSAQRDRKLLHLEQMGRYAEAHGCRMKQLVGHFGDTQDSGEPCGLCDVCAPEDCATLRFAEPTSAERHWLERILESLQERDGQATGRLHRELFGESLPRRDFERLVGGLVRAGLTRLEVDSFDKDGQVISFQRLALTDEGRRTRAVDPQRVVLPLPLEKAAKRKRGKGAEKGTAKRATAKKRTVRAKAGAATRRTASESDEEDSPTHWRANAPSKSTAGAPRASRSTGAPSGSASGRRAAAEPSPKMVEALKAWRLAEARKRRVPAFRILTDRVLEAIASACPENGSELMAIHGVGPSLTERYGAQILSLVARRS
(996) DNA topoisomerase 1 [Myxococcus xanthus DK 1622]
1
MGIERGTGMADAETDILTAEQQACLALWAVPGLGPRTLVALRAFADGSLAPLAATPVRDWVSQAPVSSQVRRKLASVERLAPVAWRVWEACRASGMKVAFQGQAAYPERLAEVEDAPPVLFYRGVPGLPRRRLAMVGSRHPDQGFLPFARRFARQVAASGVGVVSGAASGVDRACHWGALDEGGETWAFLGSALDALDTAQARLLPHFLDRGGVFFSELPPGVRASTTTFPRRNRLISGASDAVLVLRAGKDSGSLYTAEAGRAQGRPVFAMPGDVRQEEAAGCNALLRNGEAAVCLGPDDVWRVLKVDPLAAVPPGTMGSWEDLSAEAKGGLRDVGPGSPELRRGAGRQHLLTGGARQRAGGVGIDGAGHPAPRKAVRENLGRRVMATRTKKKVEETEAAEEKAPAKKAAAKKAAKKKPAAKKKTAAKKTAARRRTKKGDEDELPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREGEAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQISPLLWKKVRRGLSAGRVQSVAVRLIVEREDEIKAFVPEEYWTLDALLEGPAGPPPFKAKLSKLDGKKVELKERVFTESLVAELQTASFSVAKVDRRERRRNAPAPFITSKLQQEAANRLSFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFLPDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKPFFEAMGEEDMYRLYELIWKRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEGADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVMVEEETTDEVCEKCTKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRDGPYVACPNKECDYRREITEQPGGPGGSPEASSAA
(1339) DNA topoisomerase 1 [Gluconacetobacter diazotrophicus PAl 5]
1
MTDVVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDENFAMDWQADERGSRQMAAIAKALRGARHLYLATDPDREGEAISWHVRAMLEEKNLLKGVDVQRVTFNEITKSAIRAAMAQPRDLDQPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIESFRAREYWTVAAQFTTPGGAAFTARLTHLAGCKLDQFDLHDEAGAMAAKAAVEAGRFAVQSVERRKVRRNPPPPFTTSTMQQEASRKLGMGAQGTMRTAQQLYEGIDLGGETVGLITYMRTDGVQMAGEAIAAIRGHIGESFGAPYVPEKARIYSTKAKNAQEAHEAIRPTDVSRTPAQMARYLNDEQRRLYELIWKRSVASQMQSAELDQVIVEIADAGGAATLRATGSMIAFDGFLKLYSEGRDDAAPKDEQDDDSRMLPPMRERDALKTGEVAADQHFTQPPPRFSEASLVKKMEEIGIGRPSTYASILTVLRDRNYVRLDARRFVPEDRGRLVTAFLTSFFERYVDTQFTAGLEEQLDDISGGRADWRDVMSAFWQDFSRAVDQTKDLKISDVISALDADLAPHFFPAHPDGSDPRVCTACGTGRLGLKLGRYGAFIGCSNYPTCQFTRRLVVDPKEDGEADTLKDGMRLLGQTPGGEDVTVRRGPWGLYVQQGEPDPEDKKAKPRRATIPRGIEGDKITLDQALGLLSLPRVVGIHPETGEQIEAGLGRFGPYVKMGAVYGSLDKDDDILTVGLNRAVDVLARKLASVRTIAPHPKDGEPVIVRKGRFGPYIQHGTMVVNVPRGEAMEDVTLDQAVALLAEKGKPLKPKGKAAAKKAPARKTAARKAPAKTAAKKAAPDGDADTQARAAKPPARKAAARKTPAGKATGKTAKGKAEPGEGAGPRTRRTATEAG
(45) DNA topoisomerase 1 [Gluconacetobacter diazotrophicus PAl 5]
1
MTDVVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDENFAMDWQADERGSRQMAAIAKALRGARHLYLATDPDREGEAISWHVRAMLEEKNLLKGVDVQRVTFNEITKSAIRAAMAQPRDLDQPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIESFRAREYWTVAAQFTTPGGAAFTARLTHLAGRKLDQFDLHDEAGAMAAKAAVEAGRFAVQSVERRKVRRNPPPPFTTSTMQQEASRKLGMGAQGTMRTAQQLYEGIDLGGETVGLITYMRTDGVQMAGEAIAAIRGHIGESFGAPYVPEKARIYSTKAKNAQEAHEAIRPTDVSRTPAQMARYLNDEQRRLYELIWKRSVASQMQSAELDQVIVEIADAGGAATLRATGSMIAFDGFLKLYSEGRDDAAPKDEQDDDSRMLPPMRERDALKTGEVAADQHFTQPPPRFSEASLVKKMEEIGIGRPSTYASILTVLRDRNYVRLDARRFVPEDRGRLVTAFLTSFFERYVDTQFTAGLEEQLDDISGGRADWRDVMSAFWQDFSRAVDQTKDLKISDVISALDADLAPHFFPAHLDGSDPRVCTACGTGRLGLKLGRYGAFIGCSNYPTCQFTRRLVVDPKEDGEADTLKDGMRLLGQTPGGEDVTVRRGPWGLYVQQGEPDPEDKKAKPRRATIPRGIEGDKITLDQALGLLSLPRVVGIHPETGEQIEAGLGRFGPYVKMGAVYGSLDKDDDILTVGLNRAVDVLARKLASVRTIAPHPKDGEPVIVRKGRFGPYIQHGTMVVNVPRGEAMEDVTLDQAVALLAEKGKPLKPKGKAAAKKAPARKTAARKAPAKTAAKKAAPDGDADTQARAAKPPARKAAARKTPAGKATGKTAKGKAEPGEGAGPRTRRTATEAG
(950) DNA topoisomerase 1 [Rhodobacter capsulatus SB 1003]
1
MAVVVVESPAKAKTINKYLGSDYTVLASFGHVRDLPPKDGSVDPDADFEMKWEVAADSKKHIKAITDALANDDELILATDPDREGEAISWHLQQALASKLKKKKVSRVTFNAITKSAITEAMKAPREVDQALVDAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVCLRLIVEREMEIEAFRAREYWTVTAELTTPRGQTFTARLTVLGGKKLDKFDLTTATDAELAVQAVTSRDLTVKSVEAKPATRNPYPPFMTSTLQQEASRKFGMGAKACMSAAQRLYEAGHITYMRTDGIDMAPEAVMAARDEIKRRFGDKYVPSSPRMYKNKAKNAQEAHECIRPTDMSQSPDKLKLADDQWKLYDLIWKRTLASQMSAAVMERTTVDVGSKDNEVELRATGQVVTFDGFLKIYDQGRDDDEGEDGARLPQIMQGEPAQKGAITPEQHFTQPPPRYTEATLVKRMEELGIGRPSTYASILTTIVDRGYVRKDKNRLIPEDTGRLVTAFLSNYFRRYVEYDFTADLETELDDISAGDRPYRDVLARFWRDFSAALAETADLRIGEVLSKIDEVLGPHLYPARADGSDPRSCPVCSAGRLHLKTARSGGAFIGCGNYPDCRYTRPLSAPADGEAGVLDGKVLGEDEGAQITLRVGRFGPYVQKGEASEEIPKPPRASLPKGWSPESIDLERALQLLNLPRPIGNHPEDGALVEAGIGRFGPYVKHNSTYANLPDVEEVFTIGMNRAVEVLAQKLARGGARGSAAAAQPLKDLGEHPEGGVVQVMPGRYGPYVKWGKVNATLPKGTEPEAMTLEEALPLLEAKASKGGKKAAPKKAAKPAAEKKPAAKKAATKTATKTAAKKPAAKKAAPKKAAPEADVVED
(1113) DNA topoisomerase 1 [Wolinella succinogenes DSM 1740]
1
MKNLIIVESPTKAKTIKNFLGKEYEVIASKGHIRDLPKHNFGIKIEGQSFLPDYKIEKGHEAVVKEIKALAQKAKTIYIATDEDREGEAIGYHISHAIDKDPTTLPRIVFHEITQNAIKHALETPRSINMDMVNAQQARRLLDRIVGYRLSPLISSKIQKGLSAGRVQSSALKLIVDREREIRSFVPVTYFTIEALFEKGIEAELIEFEGEKLEKLSIGESKKANEMVKVLQKESWSITGIEHKRRKTSTPPPFMTSTLQQSASSVLGFSPSKTMMAAQKLYEGVMTHQGVMGVITYMRTDSLNIAKEAQEAARSRIKEVYGERYLPKEPKVYTTKSKSAQEAHEAIRPTLIDFTPQLAAQYLKGDELKLYSLIYNRFLASQMNDAEFELQTILLGSSKGVFKVSGRKLIFDGFYRVMGSEDKDKLLPELQKGEALKLEECKANRHETEPPARFSEASIIKTLEALGIGRPSTYAPTISLLAGRDYIRIEKKQIIPEEVAFKVIEVLEAHFTEIVDSHFTATLEEELDEIAESKKDWQKVLWDFYEKFDAKIALGKKNIESQKVAIPTGEMCPKCGAELVRRMSRYGEFVACSGYPKCKYIKPQESSPEQEGEESEEVCEKCGKPMVKKRGRNGEFLACSGYPDCKNTKSLKKSSTPKKVLEVKCPKCGGEIIERSSRRGNFFGCANYPKCDFISSHEPINEKCQKCGGMMAKRTYRKKEVHECIACKDRIEVEERNEEEK
(321) DNA topoisomerase 1 [Methylocella silvestris BL2]
1
MYVVIVESPAKAKSINKYLGKGYEVYPSYGHVRDLPAKDGSVDPDADFAMLWDVDVKSAKRLNEIARAVKDADKIILATDPDREGEAISWHVLEVLKAKKVLKDKPVERVVFNAITKSAVLEAMQHPRQIDVALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEAFVAREYWSIVAHLRTQADAPFTARLVGADGKKITRLDVGTGAEAAAFKTDLENATFRVAEIEAKPAKRHPSAPFTTSTLQQEASRKLGFAPARTMQLAQRLYEGADIDGETVGLITYMRTDGVDLAPEAITSARSVIARQFGDAYVPKAPRKYTVKAKNAQEAHEAIRPTDLARLPRAVARALEPDQAKLYELIWTRTIASQMESAELERTTVDIEALAGARKLDLRATGQVVRFDGFLKLYQEGRDDEDDDESARLPDMAKDERLKRERIEADQHFTEPPPRFTEATLVKRMEELGIGRPSTYASTLAVLRERDYVRIEKKRLHPEDKGRLVTAFLEAFFARYVGYDFTADLEEKLDRVSNHEIDWKQVLRDFWLDFSGALAGTKDLRTTEVLDRLNEILGPHIFPPKEDGSDPRGCPSCGEGKLSLKLGKFGAFIGCSNYPECKFTRTLAAPDGAEANGGERPGVKSLGVDPDSGEEITLRDGRFGVYVQQGEGEKPKRSSLPPTIAPADLTLEQAIALLSLPREVARHPESKEPIVAGIGRYGPYVQHGKTYANVAKDEDIISIGANRAIDLIVAKESGLTGRRFGASESAPARVLGEHPAGGAVSVKAGRYGPYVTHGKINATLPKEADPTTLTLEGAVALLAAKASGGGAPMQGRLLGDHPSGGPITVRAGRFGAYVNHGKTNATLKRDASAETITLEEAIRLIEDKEAAGGGPRKAAAPKKAAKSSAAAKKAAPNAKNKTAPANDEDPPFEPSPNRKPAAKAAAAAHKKPAAKAAAAKLKQAKQA
(739) DNA topoisomerase 1 [Asticcacaulis excentricus CB 48]
1
MNLVIVESPAKAKTINKYLGKDYTVLASYGHVRDLPSKDGSVKPDEDFAMSWEVDAKASKRLSDIADAARKSERVILATDPDREGEAISWHVLEVLNKKKVLKEKVVERVTFNAITKASVQEAMAAPRQIDMELVEAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALKIIVDRELEIEKFKSEEYWTVDAEVSANSPPFTARLNVLNGKKLAKFDLENAEKAEAARKAISLSKFAVESVEQKPGKRTPPPPFTTSTLQQEAARKLGFSAQRTMQTAQKLYEGVDIGGETTGLITYMRTDGVFIDPAAIGEIRKAVGERFGSAYVPSEPRLYKVKAKNAQEAHEAIRPTSIFRRPETLRLEGDQARLYELIWKRTMAAQMEAARVEKTTIDLLNHDKSIGLRSTGQVITFDGYLALYEEGKDDETDEDGGRLPQLRTGTLVDVHDIKPAQHFTEPPPRYSEASLVKRMEELGIGRPSTYASILSVLRDRDYVRMDKNRFIPEDKGRLVTAFLDQFFSRYVQYDFTADLEEKLDLVSAGDLNWKALLREFWQDFHAKAGEISEFRVSEVLDRLNDALAPHIFPDKGDGSNPRACPTCGTGQLSLKTSRFGAFVGCSNYPECKYTRPVGNPENASEVAAASGDRELGRDPETGKVVALKIGRFGPYVQLGEAESKDDKPKRSSLPKAWPPASIDLDRALKLLSLPRKVGDHPEDGKPITAALGRFGPFIEHEKTYANLPSFDEIFEVGLNRAVVLLAEKRANAKGKASTVATLKELGAHPESGDAIQVMAGRYGPYVKCGKVNATIPKDTAPEDVTLEQALALIEAKGGVKKTAAKKTTAKKAAPAKKPATKKATTSKKAPAKKAKAEA
(1418) DNA topoisomerase 1 [Acetobacter pasteurianus IFO 3283-01]
1
MTDVVVVESPAKAKTINKYLGDGYTVLASFGHVRDLPPKDGSVLPDEDFAMKWQSDERGMKQVAAIAKALKGAHRLYLATDPDREGEAISWHVRAMLEERKALKGVDVQRVTFNEITKSAIRYAMEHPRDLDFPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFKPREYWSVIASLLTPAGAAFTARLTHLNGKKLDQFDLHNAELAEAAKKAVEAENLAVKSIERRKVRRNPQPPFTTSTLQQEASRKLGMSAQTTMRTAQQLYEGMDLGGETVGLITYMRTDGVTMAQEAINAIRQHIGQKIGTEYVPAKPRIYTSKVKNAQEAHEAVRPTDVSRTPESVARFLNNDQRRLYELVWKRAVASQMESASLDQVAVDIAGPSGQTVLRANGSIITFEGFLKLYREGRDDTEKAADDDARMLPSMQEKDPLKREKVDAEQHFTQPPPRYSEASLVKKMEELGIGRPSTYASILTVLQDRSYVRLENRRFIPEARGRLVTAFLVSFFERYVDTGFTASLEELLDDISGGRAQWKQVLAAFWNDFSKAVSGTKELTITDVLNALDKDLGPFFFPERADGSDPRVCPSCGTGRLGLKLGRYGAFIGCSNYPECQYTRRLTSDSAEEGDDAALKDGMRLLGQNPETGEDITVRQGPWGLYVQQGEPNPEDKKAKPKRASLPKNINGESITLDQALGLLSLPRLVGIHPETGEPIQAGLGRFGPFVKMGAVYGSLDKDDDVLTIGLNRAVDALAKKLASIRNLGVHPKDGEPVMVRKGRFGPYVQHGQMVATLPRGTDMDAVTLDEAVALLADKGKPLKAKAGAKKKATTTKTAAKKKTATKSTAKADAEGAEKAAPKKKAPAKKKATTTTRKKKAETE
(1061) DNA topoisomerase 1 [Edwardsiella ictaluri 93-146]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKGAASAGDKAKTKAKKNERDALVNRMGVDPYHGWQAHYEVLPGKEKVVSELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDGSRYSRVVFNEITKNAIQQAFSQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEREREIKAFVPEEYWELRADLAVGADVSFQAQVTHYNDKPFKPVNAAQSQAAVTALENARFAVREREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALNMVRAYIGDNFGAEYLPTDANVYASKDNSQEAHEAIRPSDVSVLADDLKGMEADALKLYQLIWRQFVSCQMTAAKYDASTITVQAADYTLKARGRTLRFDGWTRVLPQLRKGDEDRALPAVESGRALDLLQLQPSQHFTKPPARFSEASLVRELEKRGIGRPSTYAAIISTIQDRGYVRTDNRRFYAEKMGEIVTDRLEENFRELMSYDFTAHMEDGLDRVASAQADWKVMLDGFFSDFSQQLEVAEKPPEEGGMRPNPMVLTCIACPTCERQMGIRTASTGVFLGCSGYTLSPKERCKTTINLVPEAEVLNVLEGDDAETNALRAKRRCPKCGTAMDSYLIDNHRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGAEMHLKMGRFGKYMGCTNEACKNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAEAPQQDAQGNATLVRFSRKTKQQYVSSEKDGKATGWTAFFIDGKWVVSEKK
(1169) DNA topoisomerase 3 [Edwardsiella ictaluri 93-146]
10
MRLFIAEKPSLGRAIADVLPKPHRRADGYIQCGDGDVVTWCVGHLLEQAEPDAYDARYARWNLVDLPIVPQKWQLRPKASSAKQLKVIERLLRDAQQVVHAGDPDREGQLLVDEVLDFLALAPEKRRQVQRCLINDLNPQAVARALERLRDNHEFMPLCVSALARARADWLYGINMTRAYTLLGRNAGYNGVLSVGRVQTPVLGLVVRRDEEIAHFVAKDYYEVRAHIVTPSGERFWAQWQPSEACEPHQDEEGRLLNRALAEHVIARIQDKPARVTGYNDKRESEVAPLPFSLSALQIEAAKRFAMSAQQVLDICQRLYETHKLLTYPRSDSRHLPEEHFAGRHAVMAAIATHAPTLANLESVDVQRRNRCWDDNKVDAHHAIIPTARAGGVTLNEDERNIYQLVARQYLMQFCPDAQYRKCVIDLEIEGGGFIAKARFLSQAGWRALLGAKERDDEDEGMPLPVVARDDLLHCERGELMARQTQPPRHFTDATLLSAMTGIARFVQDKSLKKILRATDGLGTEATRAGIIELLFRRGFLHKKGRYIHASQTGSALIHCLPEMAGRPDMTAHWESTLTKISERGCRYQDFMHPLVETLQQLIHQARTAVNPRAFRDLPPIENGRSRRTKGTTASNKRKKA
(1383) DNA topoisomerase [Edwardsiella ictaluri 93-146]
4
MQLYLCEKPSQAKDIARVLGISKRGQGFISADNITVTWAIGHLLEQASPDAYGEQFGKPWRVDVLPVLPDNWKMVVKPQTRDQFTVISKLLKQAGEVIIATDADREGEVIARELLAYCGYRGAVRRLWLSALDEASIREALAGILPGENTAKLYDAGLGRSRADWLIGMNLTRLYTLIARESGVSDVLSVGRVQTPTLAIVVNRDKEIADFVPVPWWQVQVLLEKDGVRFRATWQAAAQYCDDEKRCVNKQAANAVGQLCQQQKGATVLEVSQKRDKTPAPLCFDLGTLQLVCSRKFGMGAKETLAVAQSLYETHKATTYPRTDCGYLPTSMQKEIPEVMGSVAKSDPSVAPVLAQLDRGFVSRVWNDKKITAHHAIIPTRQAFDLSRLSADELKVYQLIRQHYFAQFLPLQESDVTDASFNIGGQLFLAKGKVNVITGWTCLFQKEIQEDPPEDDDMALPALNKGDSCIVNGASVGDKVTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNAGLGTEATRAGVLETLFSRHYLEKKGKHIHATLLARELIAALPETLTSPGMTALWEQALDDIAQGKMSLDTFIQKQLQWTRHLVDKGRADTVKITAPVTPPCPVCKGLTRKRKGKNGDFWGCIRYPECNGIVAGKSGGKGRKIARGKKTVVNTEVELSASQ
(54) DNA topoisomerase 1 [Desulfarculus baarsii DSM 2075]
1
MPKNLLIVESPAKARTIGKYLGPDFIVKASVGHIVDLPPSELGVDLENGFQPHYRVIKGKDKVIKELRAAAAKAGEIFLAPDPDREGEAIAMHIAQQLGRPLESYHRVLFHELTKSAIAKAVAAPAKIDVDRYNSQQARRVLDRLVGYQISPLLWDKVKRGLSAGRVQSVSLRLVVERERAIQAFEPQEYWTVTAMLQGQQPPPFAARLARLAGKKFDPKNEKEAMAGVTAIQGQRFVVEKLTKRQRKQQPAPPFITSTLQQEAYRKLGFAPKYTMGLAQALYEGKQTSEGQMGLITYMRTDSTRLAAEAVATVRALIAARYGQEYLPAKPNAYKSKANAQEAHEAIRPTNAALTPELLEAYLSRDELRLYQLIWNRFVACQMAPAVYDQTQAEIVAGQGLLRASGQVLRFRGFTAVYVEDRDEHGGDEARASAEAKDHDQALPPLPPLDEGQELALQGVEPKQHFTQPPPRFTEASLVRELEEQGIGRPSTYAAILSTIQEKDYVSKDQKRRLIPTELGYLVNDLLVECFPQIMEVGFTAQLEGLLDQVEEGRQDWRGLLADFYGPFQQALGAAKTHMRQIKGKGVETDVKCPLCGKPMAIRLGRNGEFLACSGYPECKSTSDFSRDEKGAIVLQEAAPDPGVACDKCGAAMVVKKGRFGPFLACSAYPQCKNIMALGADGKPVAKPQPEATGEKCPKCGGELVIKPTRSGGRFISCANYPKCNYSKGLSTGVKCPKCGGELVEKRSRRGKPFYGCDNFPTCDYASWDRPIDEPCPQCGHPFLVEKVGKKETVVRCPQPDCNFKK
(624) DNA topoisomerase 1 [Pseudoxanthomonas suwonensis 11-1]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPERGFAMRYDLIEKNEKHVEAIAKAARSADDIWLATDPDREGEAISWHIAEILKERGLLDGKPLRRVVFTEITPRAIKEAMTQPRTIAGELVDAQQARRALDYLVGFNLSPVLWRKVQPGLSAGRVQSPALRMIVEREEEIEAFKAREYWSIGAELAHAAQPFSAKLVKLDGQKFEQFTITDGESAEAARLRIQQAAAGALHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVTLGEEGTVGLISYMRTDSVNLSQEAVAEIRDVIARDYGTASVPDKPNTYQTKSKNAQEAHEAIRPTSALRTPGSVARFLTDDERRLYELVWKRAVASQMVPATLNTVSVDLAAGSDHVFRASGTTVVFPGFLAVYEEGKDTKTAEDEDEGRKLPPLKPGERVPLDRIHADQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLLFRKYAEMEGRAFRPTDVGRAVSKFLSGHFTRYVDYDFTARLEDELDAVSRGEEEWVPLMERFWAPFKELVEDKKESLDRTDAGSSRSLGIDPKSGKEVSARIGRFGPMVQIGTVDDEEKPKFASLQPGQSIYSISLEDALKLFDMPRNLGESNGQQVSVGIGRFGPFAKRGSTYASLKKEDDPYKIDLARAVELIEEKEEIARNRIIKEFPGSDIQVLNGRFGPYISDGKLNGKIPKDREPSTLTLEEVQQLLAETGKPARRGFGAKKAVARKAATKTAASKEAAPKKALAKKAPAKKAAKKATRKAAAKKAPAKKAAARATADDAPPF
(301) DNA topoisomerase 1 [Francisella tularensis subsp. tularensis SCHU S4]
1
MAKNLVIVESPAKTKTIKKYLGNEFEILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKAAKDAQNIYLATDPDREGEAISWHVQEVLKSARLLKDKNIYRVTFNEITKSAVTNAIANPKELSMDLVDAQKARQALDFLVGFNISPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLLEFNNNKVEQFTFTTAEDAENAKAHILKDANGFLIVDGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIQAKYDKDMLPAKPRVFEKKSQNAQEAHEAIRVTAANRTPESIKQFLTNDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHRFRVTGTVIVDAGFLKIYNVEKDEDEKDSDDEQTLPKFEKGEKIILNDVITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQREYVEVDKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLSVLNNFWHPFIERINKISEDVSRKDVVQEELEEDCPECGSKLSLRLGKNGRFIGCTNYPTCKYTRPVDSDPKEVIKEEPIVVEDRKCPKCNSDLHIKQGRYGKFIGCSNYPECKHMEPLEKPKDTGVVCPKCNKNHIVEKKSRKGKVFYACAGFPKCKNAYWYPPIKEECPKCHSPILLHKITKKDGEQKACPNSECDYAVAFETK
(1619) DNA topoisomerase 1 [Thiomicrospira crunogena XCL-2]
1
MTNLVIVESPAKAKTIEKYLGKGFTVRSSYGHIRDIQKKGMGIDIENGFMPNYEISPDKKKTVTELRKLTKEAETVWLATDEDREGEAIAWHLAEALKLDVNDTKRIVFHEITKTAIQKAIAEPRKVDMDLVEAQQARRILDRIVGFELSPILWKKIRTGLSAGRVQSVAVRLIVEREREIDAFESDYVYRLQGALDILDESQQVVGAVEVKRSAAFKTEEEAQAYLEQVKEAALTVSQLEEKPAKKSPKAPFTTSTLQQEASSKLGFSVKQTMMIAQRLYESGKITYMRTDSVNLSEEAIQKAHDEIVSEFGESYSTTRRYKTKNADAQEAHEAIRPTDFSVKSVTGERNEQRLYQLIWRRAIASQMADAQLKRTNVDIALEGMPAEKLVAKGEVITFDGFLKVYNLDDDAKEGQLPPLKVGQALKLGELLVRQSFSRPPARYNEASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVVKEDREGRQRDYRQLSLTVDGIDASTLTETTGTEKNKLFPTDIAGIVTDFLVKHFGDVLDYKFTALVESEFDTIAQGKESWQEMLTKFYQQFHPRVDAAEDVSREEAGQSRALGNDPKTGKPMFVKIGRFGPYVQLGDGENEEKPTFASLMPGQKMDTLKLEEALELFKLPREVGQMPESFSAKAVDGTEFAVEKGQIIIAKQGPFGPYLEYGPKMYAPIKGFDPLSIELEDAVALIESKIVTEAEKIIKVFPGTDVKILKGRWGPYITDVTTKKNAKIKKDEDALDLSLEECQKRLDEAPEPKKRGRVAAKKKAPAKKAAAKKTTAKKPAAKKPAAKKAPAKKTTRKTPAKKTSDKS
(1545) DNA topoisomerase 1 [Acinetobacter calcoaceticus PHEA-2]
9
MANTSRSASQSTASTAPAAHKRALVIVESPAKAKTINKYLGSQYIVKSSVGHVRDLPTGGSKSTEKKLAARTKLTEAEKEQKASQALVNRMGVDPEHGWEAHYEVLPGKENVVAELKKLAKDADAIYLATDLDREGEAIAWHLREVIGGDDSRYHRVVFNEITKNAIQEAFKQPTRLDLNRVNAQQARRFLDRVVGFMVSPLLWEKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWQVFADTQAKKDDIRLEAVKQAGKTLKLKNKAETDALLDVLKGAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEAGFITYMRTDSTFLSDDAVSMVRAHIENQFGEKYLPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGVERDAQRLYDLIWRQFVACQMTPAEYLSSTLTVEAANVELKAKGRTLVFDGFTRVRGANKSDDDIILPAIKVGEILKLEKLDPSQHFTKPPARFTEASLVKELEKRSIGRPSTYAAIISTIQERGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDKVATGERNWKELLDTFYGDFKKRLTNAQGEHGMRRNQPVEVPAVHCPECSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAALSDDDGAETADLMSKHRCAKCGTAMDSYVIDGGRKLHVCGNNPDCNGFELEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKSGQPAPPRVEPIKMEHLRSTKHDDYFVLRDGAAGLFLAASKFPKIRETRAPKVAELRSVAAQLDPKYQFILQAPDVDPEGNPTVVKFSRKNQSQYVGSETPEGKQTKWSLIYQNGKWVEG
(528) DNA topoisomerase 1 [Pseudomonas aeruginosa NCGM2.S1]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGSSSSKEPAAKGRKSASEAPALSPKEKARRQLVSRMGVDPEHGWKAKYEILPGKEKVIDELRRLAKDADTVYLATDLDREGEAIAWHLREAIGGDESRYKRVVFNEITKKAIQEAFSQPGELDINRVNAQQARRFLDRVVGYMVSPLLWQKIARGLSAGRVQSVAVKLVVEREREIRAFVPEEYWEVHADLGTAKGANVRFEVTREKGEAFKPLNEAQAMAALEKLKASAYSVAKREDRPTSSRPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAIGMVRGFIEDEFGQKYLPGKANVYSSKEGAQEAHEAIRPSDVNLKPTQLSGMERDAERLYDLIWRQFVACQMTPAEYLSTSVSVTAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMKEGENLKLIKLDPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQERGYVTTHNRRFYAEKMGDIVTDRLNESFANLMDYGFTAGMEEHLDDVAQGERDWKHLLDEFYGDFKKKLEVAEVSEKGMRANQPTLTNIPCRECGRPMMIRTASTGVFLGCSGYSLPPKERCKATVNLIPGDEIAADDEGESESRVLRGKHRCPICSTAMDAYLLDEKHKLHICGNNPDCPGYEIEEGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKNGEAAPPKMDAIRMPELKCEKVDDIYVLRDGASGMFLAASQFPKNRETRAPLVSEIIPHKAELDPKYHYLCDAPQKDPDGRPAVIRFSRKTKEQYVQSEVDGKPTGWRAFYDGGKWKVEDKR
(1177) DNA topoisomerase [Pseudomonas aeruginosa NCGM2.S1]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTITWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSVPFWAIDVSLSAEGQAFAAQWVAPDDCTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVGTERVREGPPLLFDLSTLQEVCSRQVGLDVQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLLNTDPSLRPIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSALSEKELAVYRLIRAHYLAQFLPHHEFDRTVAEFSCGQQTLVATGKQVVVKGWRLVLAEPQADEDGDDTARSQVLPPLREGLACQVAEVEIKALKTMPAKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQLIAQYGCVSLSIKLSHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTPKRGASRSRSSGRKGA
(676) DNA topoisomerase 1 [Pseudomonas mendocina NK-01]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGSASATKEPAKRGKAVAGEAPALSPKEKAKRQLFARMGVDPEHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLRESIGGDDSRYKRVVFNEITKKAIQEAFSKPGELDINRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVAREKEIRAFVPEEYWEVHADLGTAKNAKVRFEVVREGGAAFKPVNEAQAMAALEKLKASSYSVVKREDRPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSNDAVEMVRGFIGSEYGDKYLPGKPNLYSSKEGAQEAHEAIRPSDVNLRPTQLSSMERDAERLYDLIWRQFVACQMPPAEYLSTSVTVAAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMKEGEGLKLIQLDPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVTVHNRRFYAEKMGDIVTERLDESFANLMDYSFTATMEGHLDDVAQGEREWKNLLDEFYGDFKKKLEAAEAGEGGMRANQPTLTDIPCRECGRPMMIRTASTGVFLGCSGYALPPKERCKATINLVPGDEIAADDEGESESRVLLGKHRCPICSTAMDAYLLDETRKLHICGNNPDCTGYEIEQGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPSCKNTRKLLKNGEAAPPKMDKVEMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVLEIVPHKHEIDPKYHFLCDAPQKDPDGRPAVIRYSRKTKEQYVQSEVDGKPTGWRAFYDGGKWKVEDKR
(159) DNA topoisomerase 1 [Pseudomonas brassicacearum subsp. brassicacearum NFM421]
9
MGKSLVIVESPAKAKTINKYLGDQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKAAAGEAPALSPKDKARKQLVSRMGVDPEHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEVHADLGTAKGATVRFDVAREKGEAFKPLNEAQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSVDAVAMARTYIESEFGKKYLPDTPNVYSSKEGAQEAHEAIRPSDANTEPSKLSGMERDAERLYELIWRQFLACQMLPAQYLSTTVSVGAGDFELRAKGRILKFDGYTRVMPQITKPGDDDVLPDMAQGDVMKLIKLDPTQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTERLSESFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFKKKLEVAESPDSGMRANQPVMTDIPCLTCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESLVLRGKHRCPICSTAMDAYLLDEKRKLHICGNNPDCAGYEIEEGTYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKSGDAAPPKMDPVKMPELKCEKVNDTYILRDGASGLFLAASQFPKNRETRAPLVMEIVPHKDEIDPKYHFLCEAPQKDPEGRPAVIRYSRKTKEQYVQTEVDGKPTGWKAFYDGGKWTVQDKS
(56) DNA topoisomerase [Pseudomonas brassicacearum subsp. brassicacearum NFM421]
4
MRLFLCEKPSQGKDIARVLGALRRGNGCYNGPGISVTWCIGHLVEAAPPEAYDERFKRWSLDQLPIVPTNWRVDVKADTAAQYKVVKQLLAKTTELVIATDADREGEMIAREILELCHYQGSIRRLWLSALNEASIRKALTGLRPADETERLYHSALARSRADWLVGMNMSRLFTLLAQRSGHHGVLSVGRVQTPTLRLVVDRDREIERFVPMHYWGIDVHLSYQEQLFLAQWVAPDCATDDAGRCIRQAMAQQALQSVRQAQRAQVLDMQMDRIREAPPLPFDLGTLQEVCSRRFGLGVQQTLEIAQSLYETHKATTYPRSDSGYLPESMWDEASTVLDALIISDPSVEALVQSVNRQQRSRAWNDSKVSAHHGIIPTLEPFQIEALSEKERAVYELIRAHYLAQFLPHHEYDRSCALFTCGGHTLRAHGKQIVASGWHRALAPDSTTSDDDSAQRNQILPPLSTGSDCNVSQVELRTLKTQAPKALTQGELIKAMKGVAKLVTDPRLKRTLKETTGIGTEATRANIISGLLNRGYLYMKGRSVRASDAAFTLIDAVPAAIADPATTAIWEQAFDMIENGQMTLDCFIAKQTAWITQLVEHYRTTTLLIHTPGGPNCPLCGASMRQRQGKHGSFWSCSRYPECKGALPVVTKTTLAPRRRKPRHSKPKGY
(1864) DNA topoisomerase [Pseudomonas brassicacearum subsp. brassicacearum NFM421]
4
MQLYLCEKPSQAKDIAAVLGATRRGDGCWLGPGITVTWCIGHLLETAPPDAYDARYKRWVLADLPIVPAQWKMTVKPKTASQYKAVKRLLGEAKELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDEASIRKALAALKPGAETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPIAYWAIDVQLSHEGTAFTAQWRADPDACDDQERCLNQALARDAAMAMSNAASARTLKVRTERLREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQSLYETYKLITYPRSDCGFLPLSQHSEAPAILAALAQADPSLAPLREHLQPQRKSRAWNDAKVSAHHGIIPTAAARNLDKLAGKQRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKQIVEPGWKRALPEALAPARGREAPAPQTLPALAEGRDCAVDEVKPKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTRQAAWMSKHVARCQGMSLTISGPASPAGRGATPWKNKRKPAKRKAGGAPRKASKAKAT
(1235) DNA topoisomerase [Pseudomonas fluorescens F113]
4
MRLFLCEKPSQGRDIAKVLGASRRGDGCLIGRETTVTWCIGHLLETAPPEAYGDQYKTWSLDHLPIIPAQWRVEVKPKTVAQFKIIKHLLSEATTVVIATDADREGEMIARELLELCNYRGSVERLWLSALNEASIRKALSSLKSSQETFPLYHSALARSRADWLIGMNLSRLFTLLGRRAGYGAVLSVGRVQTPTLRLVVERDRAIASFVSVPYWVVNAHLSSMGQQPFIASWIPPSSGRDEAGRCLQQALASQALQAISSSKTATVVSLRTEHLREAPPLPFDLSTLQEVCSRKLGLGAQETLNIAQALYETHKATSYPRSDCRYLPESMFNEVAAVFDALLRMDPALRPALGSIDQSLRSRAWNDAKVTAHHGIIPTTEPANLGRMSEQERQVYELIRSHYLAQFLPHHEFDRTEVELECSAERLTAVGKQILVQGWKGLLSDNPDDDEPSQKSQVLPALQQGRQCAVDDVELKSMRTAAPKSLTEGDLIKAMKNVAKLVNDPRLKQKLRDTTGIGTEATRAGIIKGLIDRGYLLKKKRALMASATAHTLIEAVPAAVADPGMTAIWEQALDEIEAGRLSLDAFVAKQAHWITQLIANCGALTLSVPVEAGPVCPICNASMLRRKGKSGPFWSCSHYPDCKGTVPISKGIRRP
(411) DNA topoisomerase 1 [Pseudomonas fluorescens F113]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKAAAGEAPALSPKDKARKQLVSRMGVDPEHGWKARYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEVHADLGTAKGATVRFDVAREKGEAFKPLNEAQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSVDAVAMARTYIESEFGKKYLPDTPNVYSSKEGAQEAHEAIRPSDANTEPSKLSGMERDAERLYELIWRQFLACQMLPAQYLSTTVSVGAGDFELRAKGRILKFDGYTRVMPQITKPGDDDVLPDMAQGDVMKLIKLDPTQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTERLSESFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFKKKLEVAESPDSGMRANQPVMTDIPCLTCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESLVLRGKHRCPICSTAMDAYLLDEKRKLHICGNNPDCAGYEIEEGTYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKSGDAAPPKMDPVKMPELKCEKVNDTYILRDGASGLFLAASQFPKNRETRAPLVMEIVPHKDEIDPKYHFLCAAPQKDPEGRPAVIRYSRKTKEQYVQTEVDGKPTGWKAFYDGGKWTVQDKS
(1122) DNA topoisomerase [Pseudomonas fluorescens F113]
4
MQLYLCEKPSQAKDIAAVLGATRRGDGCWLGPGITVTWCIGHLLETAPPDAYDARYKRWVLADLPIVPAQWKMTVKPKTASQYKAVKRLLGEAKELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDEASIRKALAALKPGAETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVAYWAIDVQLSHEGTAFTAQWRADPDACDDQERCLNQALARDAAQAMANATTARTLKVRTERLREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQSLYETYKLITYPRSDCGFLPLSQHSEAPAILAALAQADPSLAPLREHLQPQRKSRAWNDAKVSAHHGIIPTAAARNLDKLAGKQRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKQIVEPGWKRALPEALAPARGREAPTPQTLPALSEGRDCAVDEVKPKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTRQAAWMSKHVARCQGMSLTISGPASPAGRGATPWKNKRKPAKRKTSGAPRKPSKAKAT
(1616) DNA topoisomerase [Pseudomonas stutzeri A1501]
4
MTVTWCIGHLLETAPPDAYDPRYKRWVLADLPIVPERWKMLVKPKTASQFKAVKRLLGECRELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDDASIRKALAALKPGAETFNLYHAALGRSRADWLIGMNMSRLFTLLGRQSGYRGVLPVGRVQTPTLRLVVDRDRSIADFIPVPFWAIDVQLLADGAAFTAQWQAPDDLCDDQGRCLDQARAQQAADAMRNAASARLLKLKTERQREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQALYETHKLITYPRSDCGYLPLSQLGEARAIVAALTQADPTLAALQPHLDLSRRSRAWNDAKVGAHHGIVPTAAARGLERLAGRPRAVYELIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKRVVEPGWKRAMPEALAPARGNREAHAPQSLPALQQGQDYAVGEITLKDQQTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQGLLDRGYLVRQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMPLEEFVAKQSAWMSKLVERCAGLRMTISGPPVAAGRNGKPWKKKRSATPRRGSGARTRKPRAAD
(1234) DNA topoisomerase 1 [Pseudomonas stutzeri A1501]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSANKEPVKRGKAAAAEAPALSPKEKAKRQLIARMGVDPEHGWKAKYEILPGKEKVIEELRRLAKEADTIYLATDLDREGEAIAWHLRESIGGDDSRYKRVVFNEITKKAIQEAFSQPGELDLNRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFVPEEYWEVHADLATAQQAKVRFEVAREKGEAFKPLNEAQANAALEKLKGASYSVTKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAISMVRGFIEGEFGDKYLPEKPNLYSSKEGAQEAHEAIRPSDVNLRPNQLSGMERDAERLYELIWRQFVACQMPPAQYLSTSVTVEAGDFELRAKGRILKFDGYTKVMPQQSKAGEDDVLPEMSKGDAMKLLKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVSLHNRRFYSEKMGDIVTERLSESFNNLMDYGFTAGMEEHLDDVAQGERDWKHVLDEFYGDFRKKLEVAESSENGMRANQPTLTDIPCKVCGRPMMIRTASTGVFLGCSGYSLPPKERCKSTVNLIPGDEIAADDEGESESRVLLGKHRCPICSTAMDAYLLDETHKLHICGNNPDCSGYEIEEGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNAECKNTRKLLKNGEPAPPKMDAVKMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVRELIPHKDEIDPKYHFLLQAPQQDPDGRPAVIRFSRKTKEQYVQSEVDGKPTGWKAFYDGGKWQVEDKR
(1732) DNA topoisomerase 1 [Pseudomonas syringae pv. syringae B728a]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASAAKDPAAKRGKAAAGEGPVLTPKEKAQRQLVSRMGVDPEHGWKAKYEILPGKEKVIEELRKLAKDADIIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSKPGELDIARVNAQQARRFLDRVVGYMVSPLLWQKVARGLSAGRVQSVAVKLVVEREREIRAFNPEEYWEIHADLGTAKGANVRFEVARENGEAFKPLNETQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAVSMARDYIGTEFGKKYLPESPNVYSSKEGAQEAHEAIRPSDVNTHPSKLTGMERDAERLYELIWRQFVACQMLPAQYLSTTVTVAASDFELRAKGRILKFDGYTRALPQMAKPGDDDVLPDMAQGETLKLNKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTGRLSESFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFRKKLEVAEAADGGMRANQPVMTDIPCKVCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLTPGDEIADDDEGESESRVLRGKHRCPICSTAMDAYLLDEKHKLHICGNNPDCTGYEIEEGTYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPDCKNTRKLLKSGDAAPPKMDPVKMPELKCDKVDDTYILRDGASGLFLAASQFPKNRETRAPLVIEIAPHKDEIDPKYHFLCEAPKKDPDGRPAVIRYSRKTKEQYVQTEVEGKPTGWRAFYDGSAWKVEDKR
(422) DNA topoisomerase [Pseudomonas syringae pv. syringae B728a]
4
MRLYLCEKPSQGKDIAAVLGAKTRGDGCIKGNGVAVTWGIGHLLETAPPDAYGEHLKNWSLDTLPILPAEWKVLVKPKTASQFKIVKQLLKQATELVIATDADREGEMIARELIEYCGYRGPIQRLWLSALNEASIRQALNTVKQGSETYPLYLSALARSRADWLIGMNFSRLFTLLGRQAGYTGVLSVGRVQTPTLRLVVDRDRDISNFIPKPFWSVEVQLWTAGQSFLAKWVADEYLVDEEGRCLDQAAAAAALAALKSSQAASTVSVDTKRGKDPAPLPFDLSTLQEVCSAKFGMGVQETLDVAQSLYETHKATTYPRTDCGYLPESMFDEVPMVLDALNRTDPSIGKTLQLIDPEQRSRAWNDKKITGPHHGIIPTLEPANLSAMSEKERKVYELIRAHFLAQFLPTHEYDRTVATFECNAVLLQAVGKRIVIPGWKVLFSASSEEEANDSGGRSQILPVLQIGTRCDVQDLHLKSLKTEPPKAYTEGTLIKAMKTIAKLVKDPRLAQKLKETTGIGTEATRAGTIQGLIDRGSLIKKGSALRATEAAFSLIDAVPPAVADPGTTAIWEQALTMIEQGTLTLDDFIARQSSWITRLVEQYKGTTLSIKVPEGPKCPLCSAKTSQRKGSSGVFWACSRYPECKGTVNIGTGKKKSPGKSAKPRAATVKSS
(655) DNA topoisomerase [Pseudomonas syringae pv. syringae B728a]
4
MRLFLCEKPSQAKDIAAALGATRRGDGCWVGANATVTWCIGHLLETAPPDAYDARYKRWVLEDLPIVPEKWKMLVKPRTASQFKAVKRLLGEATELVIATDADREGEMIARELIEHCRYRGPIQRLWLSALDDASIRKALAALKPGADTFSLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIANFVPAPYWAIDVRLLHDNQAFIAQWRAPSDACDDQDRCLNQALAQQAAQAMRAAASARLVKLRTERIREAAPLPFDLGTLQEICSKKLGLGAQETLDIAQSLYETHKVITYPRSDCGYLPNSQHGEAAGIIAALCKADPALANLSPHLDPQRRSRAWNDSKVTAHHGIIPTAAVRGVERLSGKPRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGHALRAVGKQIVEPGWKRAMPEALAPAKGREAPAPQPLPALFQGCECAVAEVILKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLTKQGKSLCAAPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVAKQAAWMSKQVSRCVGMRMSISGPASPAGVKPPWKKKRKTTTRVAKTATTDTAAKKPRRAVRPAAKA
(959) DNA topoisomerase 3 [gamma proteobacterium HdN1]
10
MKLYIAEKPSLARAIAEALPRPHNRQDSCIQLGNGDCVTWCIGHLLEQAEPDAYDAAYKKWQIAHLPILPEQWQLQPKASTRKQLSALRTLIQSADQLVHAGDPDREGQLLVDEVIHYFKVPAAKRRNMQRLLISDLNPTAVARALTQMRSNQEFTALSTSALARSRADWLYGINMTRAYTLQGQSAGYQGVLSVGRVQTPVLGLVVRRDQVIANFISVPYYEVLAHLLTPAPSETAPSLADPAHPTDSARFTARWQPSEACKPWQDDEGRVLNRALAENVARRITDQPAHVESVEKIPRKLSPPLPYSLSTLQIDAGRRYGMSAQQVLDGCQQLYERHRLITYPRSDSRHLPEDHFAQSNDVLRAIASFGEPLQSACRHANPTLRSKAWDNAKVDAHHAIIPTEKPPQTQSLSDVERKLYEQIARQYVAQFYPAHRYLETQLALRIAGGLFTASARQVQEIGWKTLYARETGHAEDTDALTEIPPLNPGDILHCERGELQEKQTRPPAHFTDASLLSAMTGVSRFVKDPEIRKILKETDGLGTEATRAGIIELLLKRGFVQREGKTLRATPTGTALIEALPESATLPDMTAQWESALEAICQQKIDYHAFIQPLIETLRTLIEQSTQTSPRSFSGLNAPKHTQRTKRKQPAQRFSKRLKSKSPASTGFSKK
(1092) DNA topoisomerase 1 [gamma proteobacterium HdN1]
9
MQKSLVIVESPAKAKTINKYLGKNFIVKSSVGHVRDLPTSGRGETATDSKQRSQKAAATRQLSAAEKEKQKKARAWEALVARMGVDPEHGWKATYQVLPDKQKVVDELRKLAKDCDSIYLATDLDREGEAIAWHLREVIGGDDSRFQRVVFNEITQSAIQEAFASPGRVNENRVNAQQARRFLDRVVGYMVSPLLWAKIGRGLSAGRVQSVAVRLLVEREREIRAFLPEEYWELFAETLTAKKTPLRLEVAREGDKAFRPTDEAQAMAAVKALQHAEYRVANREDKPTRSKASAPFITSTLQQAASTRLGFSVKRTMMLAQRLYEAGYITYMRTDSTNLSAEAVGACREYIEGRYGARYLPDAPNTYASKEGAQEAHEAIRPTDVHLMADQVSGLEKEAQKLYELIWKRFVACQMPPAEYLSTQMTVKAGEFELRAKGRILKFDGHLAVGMPGTRTSDEDIELPDVAVGEVLALKKLDPLRRFTKPPQRFTEASLVRELEKRGIGRPSTYASIISTIQERGYVRVESRRFYAEKMGDIVTDRLSESFDNLMDYGFTARMEEKLDEIAQGNLYWQNVLDEFYSRFSGQLAHAELTEGGMRSNTPVETDIPCPQCGRPMMIRTGATGVFLGCSGYNLPPKERCKGTLNLVPGEEGISATPESDEDESGELEALALRKKHRCKLCATAMDSYLVDEHRKLHVCGNNPDCPGYEVEQGQFKLKGYEGPIVECDKCGSDMQLKTGRFGKYFGCTNEECGNTRKLLRNGEVAPPRESPIPMQHLRCQKHDDFYLLRDGASGLFLAASQFPRHRETRAPTIAELKTVAEQIPEKYQYLLSAPVKDDKGNPAIVRFSRKSREQYVMSESEGKATGWSAVWADGKWVQKPAKE
(1849) DNA topoisomerase 1 [Thioalkalimicrobium cyclicum ALM1]
1
MKNLVIVESPAKAKTIEQYLGKDFVVRSSYGHIRDLSKKGMGIDIPNRFLPSYEVSPDKKKTVTELRKLAKEADAVWLATDEDREGEAIAWHLAEALNLNVAETKRIVFHEITKPAITQAVANPRQVDLNLVNAQQARRILDRVVGFELSPILWKKIRTGLSAGRVQSVAVRLIVEREREIDAFTPVSSFKVSGELYTLNAQGQPDEMLPVKRLAAFDDEASAQAYLASLTGATFSVAQLDQKPAKRSPKPPFTTSTLQQEASQKLGFSVKQTMVIAQRLYESGKITYMRTDSVNLSEVAIGQAKDVITKRFGANYSHPRRYKTKQADAQEAHEAIRPTDFSVTEVGGERNEQRLYQLIWARALASQMSEAELLRSQVDIAIAPSNNELLVAKGEVVTFEGFMKVYNLDGQKDQDVLLPALKVGQNLQPVLLQAKQSFSRAPARYNEASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVIKEDREGSPRAVRLLSWQAGQVKAETLEEITGSEKNKLFPTDIAGIVNDFLVKNFGQVLDFQFTAQVEAKFDQIAMGQQAWQDMLEDFYHKFHPNVELAETLSREEAGQARLLGNDPKTGKPMLVKIGRFGPFVQLGDGENDEKPTFASLKPGQKMDTIKLEEALELFKLPRVLGDMPEAYHAAAADGTPFGVEQGQTITAKQGPFGPYLEYGEKQFAPIKGYDPLSITLEEAVLVIEAKIQADADKIVRSFPSTDVKILKGRWGPYITDTVTKVNAKIAKDEDPMELTLEECQTRLAAAPPPKKRGRAAAAKKPAAKRAPAKKTTTKKVTAKK
(955) DNA topoisomerase 3 [Erwinia amylovora CFBP1430]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGSDQVVTWCVGHLLEQAQPDSYNGRFARWSLADLPIVPEKWRLQPRPSVAKQLNVIKGLLSQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKHAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVAKDFFEVRAHIVTPADERFVALWQPSDSCEPYQDDEGRLLHRPLAEHVVARIGGQPAHVTSYNDKRENETAPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRHLPDEHFAGRHAVLNAINIHLPNLTPPGDFNSDQKNRCWDDKKVDAHHAIIPTARSSQVALSDHERQIYCLIATQYLMQFCPDAIYRKCVIELAIAGGKFLAKARFLAEAGWRALLGSKERDEENDGTPLPVVTRGDELLCERGEVLEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRSFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMSPLVETLHSLIQQARQQPAAYAFRGLPAPATDKTKRPRRKTAQKKESET
(568) DNA topoisomerase 1 [Erwinia amylovora CFBP1430]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGTTVKKSTDSTTSKPTKKVKKDEKTALVNRMGVDPFHGWAANYQILPGKEKVVSELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIRHAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELNADLTTPKGVDLPMQVTHQHDKPFRPINRDQTYAAVSLLEKARYVVVDREDKPTGSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMARGYIEEEFGAKYLPKTANLYSSKENSQEAHEAIRPSDVKVQSEQLKDMETDAQKLYQLIWRQFVACQMMPAQFDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDDRTLPAVEVGSELSLQQLLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNQAQWKAVLDKFFGDFSQQLEQAEKDPEEGGMQPNQMVVTSIECPSCSRQMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCGKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEQGEFRIKGYDGPVVECEKCGGEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPRVEELQRFRDRLPEKLRYLADAPAEDAEGNKAVVRFSRKNKQQYVSTEKEGKATGWSAFYVDGKWEVAKK
(79) DNA topoisomerase 1 [Erwinia tasmaniensis]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPISGSTVKKSTDSTTSKTTKKVKKDAKTALVSRMGVDPFHHWEANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIHQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWDLNADLTTPKGIDLPMQVTHQHDKPFRPVNRDQTYAAVSVLENARFTVVDREDKPTSSKPGAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVSMVRGYVEDEFGAKYLPKTANIYSSKENSQEAHEAIRPSDVKIQSEQLKDMEADAQKLYQLIWRQFVACQMMPAQYDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDERTLPAVEVGSELSLQQLLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNEAQWKTVLDKFFGEFSQQLEQAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCDKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEQGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEDCKNTRKILRNGDVAPPKEDPVPLPELVCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPQVEELQRFRDRLPEKLRYLADAPAEDADGNKSVVRFSRKTKQQYVSTEKDGKATGWSAFFVDGKWEVAAKK
(1269) DNA topoisomerase 3 [Erwinia tasmaniensis]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGGDQVVTWCVGHLLEQAQPDSYNSRFARWSLADLPIVPEKWRLQPRPSVAKQLNVIKGLLEQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKRAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVAKDFFEVRAHIVTPADERFVALWQPSDSCEPYQDEEGRLLHRPLAEHVVARINGQPAHVTSYNDKRENDTPPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINLHQPDLSAPTDFNSDQKNRCWDDKKVDAHHAIIPTARSGQVRLTDNEGQIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFLAKARFLAEAGWRALLGSKERDEENDGTPLPVVAKGDALLCERGEVLEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAQWESTLTKISEKQCRYQDFMSPLVETLHSLIHQARQQPAAHAFRGLPPPASDKVKKTRRKTTKKKESEA
(517) DNA topoisomerase [Erwinia sp. Ejp617]
4
MRLFICEKPSQGRDLAAVLGATQRGDGFLAGSGITVTWAVGHLLETAPPEAYGQQYGKPWTLAALPIIPSPWQVVVKKETQHQFKIIERLLRQVDEVIIATDADREGEVIARELLDYCRWEGPVQRLWLSSLDELSIRAALQNLRPGGETLGMYHAGLGRARADWLTGMNLSRLYTLRAAEAGFDGVVSVGRVQSPTLALVVRRDREIAAFVPKPYWQVKAQLSAGGITFPAQWVPAKVYTDEEKRCIHQNIAQQVVQICRQSGEATVTECETKREKASPPLAFSLGTLQQAASRLWDMSPQQVLDTAQSLYEKHKATSYPRTDCGYLPESMREEIPALLDAIGRTDPECLPLLSQLDASLVSRIWNDKKITAHHGIIPTRNAFQLSALSETERQVYMLIRRNYLAQFLPLHESDITRLAFDIGGQLFRTTGRTEVVKGWKVLFGKAEEEGSAADDEAVVALPPLKKDDRCGVTGAEVVQLMTRPPAHYTFATLIGAMMNAAAFVTDVALRKVLKDNAGLGTEATRAGIVEQLLNRRFIVRKSSKLLATDLGSDVIDSLPPQLTEPGMTALWEQALDEVAAGRMSLSDFLQRQTGWTRNLVSQGAQQQVSIRIPPTPPCPLCGGKTRLRKGQKGDFWSCQRYPDCKGVINIGSGKRKSPRKAKSPKPNKN
(407) DNA topoisomerase 3 [Erwinia sp. Ejp617]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGSDQVVTWCVGHLLEQAQPDSYNSRFARWSLDDLPIVPEKWRLQPRPSVAKQLNVIKGLLTQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKRAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVAKDFFEVRAHIVTPADERFVALWQPSASCEPYQDEEGRLLHRPLAEHVVARIGGQPAHVTSYNDKRENETAPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINVHQPNLSPPGDFNSDQKNRCWDDKKVDAHHAIIPTARSSQVSLSDNEQQIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFVAKARFLAEAGWRALLGSKERDEENDGTPLPVVTKGDELLCERGEVQEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMSPLVDTLHSLIQQARQQPAAHAFRGLPASATDKTKRPRRKTAQKKESET
(377) DNA topoisomerase 1 [Erwinia sp. Ejp617]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTVKKSADSTTSKTTKKVKKDEKTALVNRMGVDPFHGWEANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIRQAFDRPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVDREREIKAFVPEEYWELNADLTTPKGVDLPMQVTHQHDKPFRPINREQTYAAVSLLEKARYVVVDREDKPTGSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMVRGYVEEEFGAKYLPKTANLYSSKENSQEAHEAIRPSDVKVQSEQLKDMEADAQKLYQLIWRQFVACQMVPAQFDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDDRTLPAVEVGSELSLQQLLPGQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNEAQWKAVLDQFFGDFSQQLEQAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALSPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCGKCGTAMDSYLIDNQRKLHVCGNNPECDGYDIEQGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPQVEELQRFRDRLPEKLRYLADAPAKDADGNKAVVRFSRKTKQQYVSTEKDGKASGWSAFYVDGKWEVTKK
(437) DNA topoisomerase 1 [Moraxella catarrhalis RH4]
9
MATSKKTTTKAEAALTKANARGKSLVIVESPAKAKTINKYLGKDYVVRSSVGHVRDLPVGGSATKTNKTQDVGLSREEKAQKALVRRMGVDPEHDWAAVYEILPNKTKVIRELKALAKEADKIYLATDLDREGEAIAWHLKEVIGGSDDKYSRVVFNEITKTAIQTAFEHPDQLNIDRVNAQQARRFLDRVVGFMVSPLLWAKIARGLSAGRVQSVATRLVVEREREIRAFVPVEYWKIHTNNTAAGETLNLEAVKKNGKTLKLGNKAQADEVVLALGSSDFIVSAIEEKPTQSRPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSQDALNLVREYITDHFGDDYLPQKPNFYGNKQNAQEAHEAIRPSHVLVKSSQLTGMERDAQRLYELIWRQFVACQMMPARYQSVNLMVAAGDIELKAKGRTLVFDGYTKVQPPAKTDDILLPAVKVGEKLPLIEILPTQHFTSPPARYSEASLVKELESLGIGRPSTYASIISTIQERGYVKLENKRLYAEKMGDIVTERLVESFPDLMDYAFTAGLEDKLDEVAVGEEDWKTVLDRFYHDFKQKLDYAKTTDGMRPNNPTNVPDIHCDLCHRPMQIRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVSAFEFDADDDSAEVNALMEKKRCPKCNTAMDGYIVDGGLKLHICGNNPDCDGHVLEKGVFEIGGATSDTPTIDCDKCDGQMELKTGRFGAYFACRKCDNTRKVLKNGQAAPPRMTPIDMPKLRSQKFDDHYVLREGAAGLFLAASKFPKVRETRPPKLSELREIKDQLEPKFYYLFDAPDTDDVGNPTILRWSRKNQEQYVGSEKDGKATRFALVWRDGAWVQA
(438) DNA topoisomerase 1 [Moraxella catarrhalis RH4]
9
MATSKKTTTKAEAALTKANARGKSLVIVESPAKAKTINKYLGKDYVVRSSVGHVRDLPVGGSATKTNKTQDVGLSREEKAQKALVRRMGVDPEHDWAAVYEILPNKTKVIRELKALAKEADKIYLATDLDREGEAIAWHLKEVIGGSDDKYSRVVFNEITKTAIQTAFEHPDQLNIDRVNAQQARRFLDRVVGFMVSPLLWAKIARGLSAGRVQSVATRLVVEREREIRAFVPVEYWKIHTNNTAAGETLNLEAVKKNGKTLKLGNKAQADEVVLALGSSDFIVSAIEEKPTQSRPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSQDALNLVREYITDHFGDDYLPQKPNFYGNKQNAQEAHEAIRPSHVLVKSSQLTGMERDAQRLYELIWRQFVACQMMPARYQSVNLMVAAGDIELKAKGRTLVFDGYTKVQPPAKTDDILLPAVKVGEKLPLIEILPTQHFTSPPARYSEASLVKELESLGIGRPSTYASIISTIQERGYVKLENKRLYAEKMGDIVTERLVESFPDLMDYAFTAGLEDKLDEVAVGEEDWKTVLDRFYHDFKQKLDYAKTTDGMRPNNPTNVPDIHCDLCHRPMQIRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVSAFEFDADDDSAEVNALMEKKRCPKCNTAMDGYIVDGGLKLHICGNNPDCDGHVLEKGVFEIGGATSDTPTIDCDKCDGQMELKTGRFGAYFACRKCDNTRKVLKNGQAAPPRMTPIDMPKLRSQKFDDHYVLREGAAGLFLAASKFPKVRETRPPKLSELREIKDQLEPKFYYLFDAPDTDDVGNPTILRWSRKNQEQYVGSEKDGKATRFALVWRDGAWVQA
(203) DNA topoisomerase 1 [Psychrobacter sp. PRwf-1]
9
MAKTTAKKTTSTPAASAKGKSLVIVESPAKAKTINKYLGDDFIVRSSIGHVRDLPTSSGVKKKATKTDEKLSKEDKAQQALVRRMGIDPEHGWKAVYEVLPNKTKVIKELKALAKDADKIYLATDLDREGEAIAWHLREVIGGDDSKYQRVVFNEITKSAIQNAFKEPGKLDIDRVNAQQARRFLDRVVGFMVSPLLWQKIARGLSAGRVQSVATRLVVEREREIRAFIPEEYWQIHADTTMKGSENANVAADTPIRLEAVKQAGKVLKLGNKAQTDAVLAVLKPATFVVKEREEKPTQSKPSAPFITSTLQQAASTRLGFPVKKTMMLAQRLYEAGHITYMRTDSTFLSNDALASVRGFIEENYGSKYLPEKPNFYGSKQNAQEAHEAIRPTNANLKSTQLKGVDRDAIRLYELIWRQFVACQMLPAKYKSVNLLVEAGDVELKARGRTMTFDGFTKVMPPAKTDDTLLPDVKQGDELNLIKLDPSQHFTKPPARYTEASLVKELEKKGIGRPSTYASIISTIQDRGYVRLENKRLYAEKMGDIVTDRLTESFPELMDYTFTAGLEDELDHVAQGDQDWKAVLDDFYGDFKTKLEHAKDKDGMRPNDPTDVPDVHCDLCGRPMQLRNGSTGVFLGCTGYNLPPKERCKGTKNLMPVEAFANLDDSEIDESAEVKELMEKKRCPKCSTAMDGYIVDGGLKLHICGNNPDCDGYLLEEGMFEVPGSDAPTIDCNKCDGQMELKTGRFGPYFACNKCDNTRKVLKNGEPAPPRMDPIDMPELKSTKHEDHFILREGAAGLFLAASKFPKVRETRPPKLSELRTIKDKMDDKFQYLFDGPDQDPEGNPTILRWSRKQKEQYIGSESLKTGKATRWGVYWRKGEWVEE
(826) DNA topoisomerase 1 [Psychrobacter cryohalolentis K5]
9
MTKPAAKKSAAPAADKPKGSPKASPKGKSLVIVESPAKAKTINKYLGDDFIVRSSIGHVRDLPVGASKSAKKPATTKKDDSLSKEEKTQQALVRRMGVDPEHDWAAVYEVLPNKTKVIKELKALAKDADKIYLATDMDREGEAIAWHLKEVIGGADSKYERVVFNEITKSAIQNAFKQPSKLDIDRVNAQQARRFLDRVVGFMVSPLLWQKVARGLSAGRVQSVAMRLVVEREHEIRAFIPEEYWQIHADTHIADSKAKKAADAEQIGIRLEATKQGGKTLKLVNKEQTDKVLDVLKANDFIVKEREEKPTQSKPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSGDALAAVRGYIEDSYGAKYVPEKPNFYGNKQGAQEAHEAIRPSNVNMKSTQLKAVERDAIRLYELIWRQFVACQMLPAKYLSVNLFVAADDVELKARGRTLVFDGFTKVMPPAKTDDNLLPDVKKGDKLILDKLDPSQHFTKPPPRFTEASLVKELEKKGIGRPSTYASIISTIQDRGYVKLENKRLFAEKMGDIVTDRLTASFPDLMDYTFTAALEDKLDHVAEGDTDWKDVLDNFYGDFKTTLDRAKEKDGMRPNDPTDVPDVHCDLCARPMQLRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVEAFANLDDAEGDDEAAEVRDLMEKKRCPKCGTAMNGYIVDGGLKLHVCGNNPDCDGYVLEEGKFEVPGSDSPTIDCNKCDGQMELKTGRFGPYFACQQCDNTRKVLKTGEAAPPRMDPIHLPELKSVKHEDYFILREGAAGMFLAASKFPKVRETRPPKLAELREIKDKMEDKFQYLFEGPDEDPDGNPTILRWSRKKKEQYIGSEKNGKATRWGVYWRKGEWVEE
(1437) DNA topoisomerase 1 [Francisella sp. TX077308]
1
MAKNLVIVESPAKTKTIKKYLGNNFDILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKSAKNAENIYLATDPDREGEAISWHVQEVLKNARLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVNAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFVKKDYWSLTADIFKQKQIFANLTEFDGTKVEQFTFTAEKDAENAKATITKDANGFLIVEGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGMDLGNGESVGLISYMRTDSTNLSNDALNDIRSFIESKFDKDMLPSKPRVFGKKSQNAQEAHEAIRVTSASKTPESMKPYLTTDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENEKHKFRVTGTVIVDAGFLKIYNVEKDEDEKESNDEQTLPKFEKGEKVPLKDIITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQRDYAEVEKRRFIPTDKGRVVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLTVLNSFWKPFIERINKIAEDVSRKDVVQEELDEDCPECGSKLSSRLGKNGRFIGCTNYPTCKYTRRVDSDGKEIEKEEPTVVEDRKCPECGSNLHIKQGRYGKFIGCSNYPTCKHMEPLEKPKDTGVVCPKCNKNNIVEKKSRKGKVFYACSGFPKCKNAYWYPPIKEECPKCKSPILLHKTTKKDGEQKACPNPECDYAVPWEENK
(1698) DNA topoisomerase 3 [Enterobacter aerogenes KCTC 2190]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDGRYARWNLLDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQDERFIATWVPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPAIVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAISVHAPDLLPQPVMDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLNDNEEKVYNLIARQYLMQFCPDAVFRKCQIDLDIANGKFVAKARFLAEAGWRALLGNKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRGFLNKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFQLIDQARSTPVRQFRGLVAPGGAKKSFSKGKGKPKGKKPEADIAPESPQ
(1358) DNA topoisomerase 1 [Enterobacter aerogenes KCTC 2190]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERGALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPGGDALPLQVTHKNDKPFRPVNRDETMAAVALLEKALYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGDNFGKKYLPENANQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGEFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPVVNQGDNLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRAENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKQVLDNFFGDFTSQLQTAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFFIDGKWTEAKK
(862) DNA topoisomerase 1 [Acinetobacter oleivorans DR1]
9
MANTSRSASQSTASTAPAAHKRALVIVESPAKAKTINKYLGSQFIVKSSVGHVRDLPTGGSKSTEKKPAARTKLTEAEKEQKASQALVNRMGVDPEHGWEAHYEVLPGKENVVAELKKLAKDADAIYLATDLDREGEAIAWHLREVIGGDDSRYHRVVFNEITKNAIQEAFKQPTRLDLNRVNAQQARRFLDRVVGFMVSPLLWEKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWQVFADTQAKKDDIRLEAFRQAGKTLKLKNKAETDALLDVLKGAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEAGFITYMRTDSTFLSDDAVSMVRAHIESQYGEKYLPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGVERDAQRLYDLIWRQFVACQMTPAEYLSSTLIVEAANVELKAKGRTLVFEGFTKVRGANKSDDDIILPAIKVGEILKLEKLDPSQHFTKPPARFTEASLVKELEKRSIGRPSTYAAIISTIQERGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDKVATGERNWKELLDTFYGDFKKRLTNAQGEHGMRRNQPVEVPAVHCPECSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAALSDDDGAETADLMSKHRCAKCGTAMDSYVIDGGRKLHVCGNNPDCDGFELEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKSGQPAPPRVEPIKMEHLRSAKHDDFFVLRDGAAGLFLAASKFPKIRETRAPKVAELRSVAAQLDPKYQFILQAPDVDPEGNPTIVKFSRKNQSQYVGSETPEGKQTKWSLVYQDGKWVEG
(717) DNA topoisomerase 3 [Klebsiella variicola At-22]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLTDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVATWVPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPALVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADLLPQPVMDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLTDNEAKVYHLIARQYLMQFCPDAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFQLIDQARSTPVRQFRGLAAPGGAKKSFSKGKGKPKGKKAADDAAPPPQ
(972) DNA topoisomerase 1 [Klebsiella variicola At-22]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSTDSTATKGAKKPKKDERGALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVIHKDDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDNFGKKYLPESANQYASKENSQEAHEAIRPSDVSVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPVVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLETAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVASEKEGKATGWSAFFIDDKWTEAKK
(160) DNA topoisomerase 1 [Acinetobacter sp. ADP1]
9
MANAPRSTTKKSTTASSEPAGNKRALVIVESPAKAKTINKYLGSQYIVKSSVGHVRDLPTGGSAKSGEKKPATRAKLTAEEKEQKAQNALINRMGVDPEHDWKAHYEVLPGKEHVVAELKKLASQVDEVYLATDLDREGEAIAWHLKEVIGGDDSRYQRVVFNEITKNAIQEAFKHPARLDTNKVNAQQARRFLDRVVGFMISPLLWEKIARGLSAGRVQSVAVKLVVERERDIRAFIPEEYWQIFADTLSKKDQIRLEAVKQAGKTLKLRNKADTDAVLNLLKDAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEGGFITYMRTDSTFLSDDAVNMVRDHIQQQFGDKYVPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGMERDAQRLYDLIWRQFVACQMTPAEYLSSTLIVDANNVELRAKGRTLVFDGFTRVRGANKSDDDVLLPAVKVGETLKLEKLDPSQHFTKPPARFTEASLVKELEKRGIGRPSTYAAIISTIQDRGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDKVATGERNWKELLDSFYGDFKNRLNMAASTEGMRRNQPVEVPDVACQLCSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAAFSDDDSAETADLMAKHRCAKCGTAMDSYVIDGGRKLHVCGNNPDCDGYEVEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKSGQPAPPRVDPIKMEHLRSVKHDDYFVLRDGAAGLFLAASKFPKIRETRAPKVAELRTVAEQLDPKYQYLLQAPDADPEGNPALIKFSRKNQAQYVGSETPEGKQTKWSLVYQDGKWTEA
(1489) DNA topoisomerase 1 [Acinetobacter baumannii ATCC 17978]
9
MANTSRSASQSTASSASAAHKRALVIVESPAKAKTINKYLGSQYIVKSSVGHVRDLPTGGSKATEKKPAARTKLTEAEKEQKANQALINRMGVDPEHGWQAHYEVLPGKENVVAELKKLAKDADAIYLATDLDREGEAIAWHLREVIGGDDSRYHRVVFNEITKNAIQEAFKQPTRLDLNRVNAQQARRFLDRVVGFMVSPLLWEKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWQVFADTKAKKDDIRLEAVKQAGKTLKLKNKAETDALLDVLKGAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEAGFITYMRTDSTFLSDDAVSMVRAHIESQYGEKYLPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGVERDAQRLYDLIWRQFVACQMTPAEYLSSTLTVEAGNVELKAKGRTLVFDGFTKVRGANKSDDDIILPAIKVGEILKLEKLDPSQHFTKPPARFTEASLVKELEKRGIGRPSTYAAIISTIQERGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDRVATGERNWKELLDTFYGDFKKRLTNAQGEQGMRRNQPVEVPAVHCPECSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAALSDDDSAETADLMSKHRCPKCGTAMDSYVIDGGRKLHVCGNNPDCDGYELEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKNGQPAPPRVEPIKMEHLRSTKHDDYFVLRDGAAGLFLAASKFPKIRETRAPKVAELRSVADQLDPKYQFILQAPDVDPEGNPTIVKFSRKNQSQYVGSETPEGKQTKWSLIYQDGKWIEG
(1590) DNA topoisomerase 3 [Klebsiella pneumoniae KCTC 2242]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDIYDSRYARWNLNDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVATWVPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPAIVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADLLPQPVVDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLTDNEAKVYTLIARQYLMQFCPDAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCERGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLSKKGRYIHSSEAGRALIHSLPEMAGRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQARSTPVRQFRGLVAPGGAKKSFSKGKGKPKGKKAADDTAPPPQ
(730) DNA topoisomerase 1 [Klebsiella pneumoniae KCTC 2242]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTATKGAKKPKKDERSALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVTHKDDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASKENSQEAHEAIRPSDVNVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLATAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVASEKEGKATGWSAFFIDGKWTEAKK
(1417) DNA topoisomerase 3 [Enterobacter asburiae LF7a]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLNDLPIVPEKWRLQPRPSVTKQLNVIKRFLHEASEVIHAGDPDREGQLLVDEVLDYLELAPEKRQQVQRCLINDLNPQAVERAISRLRANSEFIPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPKEERFTATWQPSDACESYQDEEGRLLHRPLADHVVNRITGQPAIVTSYNDKRESEPAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHYAGRHSVMNAIGVHAPDLLPQPAVNPDTRNRCWDDKKVDAHHAIIPTARTSNVNLTENESKVYNLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLEKKGRYIHSTEPGRALIHSLPELAARPDMTAHWESILTQISEKQCRYQDFMQPLVGTLYQLIDQARSTPVKTFRGMVAPGGGAKKPFKKKKSAA
(1116) DNA topoisomerase 1 [Enterobacter asburiae LF7a]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERSALVNRMGVNPWHNWDAQYEVLPGKEKVVNELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDANVTTPGGDALPLQVSHQNDKPFRPENREQTMAAVALLEKARYQVLEREDKPTSSKPGAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESANQFASKENSQEAHEAIRPSDVSVLAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDELSLVDLVPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEANFRELMNYDFTAQMEDSLDQVASHQAEWKKVLDSFFSDFTNQLDKAEKDPEEGGMLPNQMVLTSIDCPTCGRKMGIRTATTGVFLGCSGYALSPKERCKTTINLVPENEVLNILEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKEGKATGWSAFFVDGKWAEGKK
(1591) DNA topoisomerase 3 [Enterobacter lignolyticus SCF1]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLTDLPIVPEKWQLQPRPSVTKQLNVIKRLLQDASEVIHAGDPDREGQLLVDEVLDYLNLAADKRQQVQRCLINDLNPQAVERAISRLRANSEFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPADERFTALWQPSEACEPYQDEEGRLLHRPLADHVVSRISGQPAMVTAYNDKRESEPAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRQAVLNAISVHAPDLLPQPAVDPEVRNRCWDDKKVDAHHAIIPTARSSSVKLSDNEANVYGLVARQYLMQFCADAVYRKCQIDLDIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVEKGAELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLVKKGRYIHSTEAGRALIHSLPEMAGRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFSLIDQARRTPVKQFRGLVAPGGDKKKTFARKGGKRKTAAE
(755) DNA topoisomerase 1 [Enterobacter lignolyticus SCF1]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSATKKSADSASTKTAKKPKKDERGALVNRMGVDPWHDWKAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFVDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPSGEVLPLQVSHYLDKPFRPVTRDETMAAVSLLEKARYSVVEREDKPTSSKPGAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALNMVRGYISDSFGKKYLPESANQYASKENSQEAHEAIRPSDVNVMAEALKDMETDAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDYKLKARGRTLRFDGWTKVMPALRKGDEDRTLPPVKQGDALSLVELQPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKEVLNDFFGDFTRQLETAEKGPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCAKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELHRFRDRLPEKLRYLADAPQEDGQGNKTMVRFSRKTKQQYVASEKDGKATGWSAFFVDGKWQEAKK
(947) DNA topoisomerase 1 [Enterobacter sp. 638]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSASKKSADSTSTKGAKKPKKDERSALVNRMGVDPWHEWEAQYEVLPGKEKVVNELKQLAEKADHIYLATDLDREGEAIAWHLREIIGGDETRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANVTTPAGDALPLQVTHENDKPFRPVNRDHTMAAVAQLEKARYQVVEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVTMVRDYIGENFGKKYLPESANQYASKENSQEAHEAIRPSDVSVVSESLKDMETDAQKLYQLIWRQFVACQMNPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPPVNKGDELSLTELLPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRAENRRFYAEKMGEIVTDRLEANFRELMNYDFTAQMEDRLDQVANHQAEWKNVLDSFFSDFTEQLAKAEKDPEEGGMQPNQMVLTSIDCPTCSRQMGIRTATTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLRMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPLQDPEGNKTVVRFSRKTKQQYVSAEKEGKATGWSAFFIDGKWVEGKK
(224) DNA topoisomerase 3 [Enterobacter sp. 638]
10
MRLYIAEKPSLARAIADVLPKPHRKGDGFIECGKGQVVTWCIGHLLEQAQPDVYDSRYARWNLNDLPIVPEKWRLQPRPSVTKQLNVIKRFLHDAAEIVHAGDPDREGQLLVDEVLDYLELAPEKRKQVQRCLINDLNPQAVERAISRLRSNNEFIPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPKDERFVAVWQPSEACEPYQDEEGRLLHRPLAEHVVNRIAGQPAIVTSYNDKRESEPAPLPFSLSALQIEAGKRYGMSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIGVHTPDLLPQPAVNLETRNRCWDDKKVDAHHAIIPTARASNVNLTENESKVYQLVARQYLMQFCADAMFRKCVIELEIAKAKFVAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKNDELLCEKGEVIERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLIKKGRYIQSTDPGRALIHSLPELAARPDMTAHWESILTKISEKECRYQDFMQPLVGTLFDLINQARTTPVKNFRGMVAPGGAKKPFKKKKSAA
(1627) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhi]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLSVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(150) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(148) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(1628) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhi]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLSVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(149) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(94) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(1228) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(196) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Newport str. SL254]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(1239) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Newport str. SL254]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFMLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1332) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
10
MANWSRPAAVALWLRFVNLMRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAKETGRQTE
(896) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQLLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(500) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
7
MDLYICEKPSQAKDLAGVMKASQRGDGFIHDGGNRVITWAFGHLLELYMPDDYDERYKSWSLETLPIAPDAWRYNVRKSALKQYKIVEGLVKKASTIYISTDFDREGEAIARSLLDQFRYSGPIRRVCLTALDESSIKKALNNVKDGKETVSLYYAALARQRADWLVGMNVSRLYTVLARDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEECSDEQGRCINKAYAEQVSSQVNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGYTAQQVLDAAQALYETHKATTYPRTDSRYLPESQKENIPDILQALILSDQNVSGLVAGADPHRKARVFNDSKVTAHHAIIPTPARTDISAMSEIELNLYDAIRRFYIAQFYSEFEFTKTSIEVQCGRHLFAASGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALLNGTELMNKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGTVDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVATGSGNMSVFMKQISTWICQMVDQLKVAAPVLTKEGSAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQNEACKKTFPDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTMPFKKSDL
(316) DNA topoisomerase 3 [Xenorhabdus nematophila ATCC 19061]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIECGNNQFVTWCVGHLLEQAEPDAYDSRYARWVLTDLPIIPEKWQLKPRPAVAKQLNTIKSLLERASEIVHAGDPDREGQLLVDEVLDFLDLDAEKKQNVQRCLINDLNPQAVIKAVERLRNNREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFVPKDFFEVKAHIVTPSEERFTAIWQPSESCIDFQDEEGRIIHRPLAEHVVARITGQPAIVTAYQDKRESETAPLPFSLSSLQIEAAKRYGLSAQDVLDICQRLYETHKLITYPRSDSRYLPEEHFTGRHAVLNAISVHAAHLLPQDALDTERKNRCWDDKKVDAHHAIVPTARSSQVNLTKNENDIYSLIARQYLMQFFPDAIFRKCTIELDIAGGKFIAKARFLAEAGWRTLLGHKERDEENEGTPLPIVAKGDELLCEKGEMVERQTQPPRPFTDATLLSAMTGIARFVQDKALKKVLRATDGLGTEATRAGIIELLFRREFLYKKGRHIHATPAGRALIHVLPDMAVLPDMTAHWESRLTQISEKQFRYQDFMSPLQETLQQLIRQAKQYRNLKAFRDLPPVPAKGKKGKQLKSSKSKNR
(549) DNA topoisomerase 1 [Xenorhabdus nematophila ATCC 19061]
9
MAKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGAASQKSSISSTDKNKKKVKKDEKTALVSRMGVDPYHDWEANYQILPGKEKVVAELKTLAEKAEHVYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAITQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWQLHADLVAKGEIALRMEVTHEKGKPFKPVNAQQTHAAVSLLEKAKYSVIDREDRPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALDMARGYISTHFGDKYLPKEGNVYSSKENSQEAHEAIRPSNVEVMAEELKDMEADAQKLYQLIWRQFIACQMMPAKYDSTTLTVQAGNFELRAKGRTLRFDGWTKVMPVLRKGDEDNTLPAIEANTELDLQQLFPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVHVENRRFYAEKMGEIVNDRLEENFNELMSYDFTARMEDQLDHVANNEANWKGVLDEFFSNFSEQLDVASKEPDEGGMRPNPMVITSIDCPTCCRAMGIRTATTGVFLGCSGYALSPKERCKQTINLIPENEILNILEGDDAETNALRARRRCKKCGTAMDSYLIDNQRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGSEMHLKMGRFGKYMGCTNEECKNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLHYLAEAPVADPEGNKTVVRFSRKTKQQYVSSEKNGKATGWAAFFVEGSWAVKEK
(1543) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGGSITVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILPGEQTESLWQAGLGRARADWLTGINLTRLYTLKAQEQGFGEVLSIGRVQTPTLALVVNRDNDIARFEQKPYWQVMATLQKDDISFRAKWLPAPDDGDEEKRCIREDIAQRVVQRCQQAQDAVVTELTQKREKTPPPLCFDLGTLQQVASRQWGMGAGQVLTIAQSLYETHKATTYPRTDCGYLPVSMRENIPAVFTALTRTDPAMSAIISQLDASAFSRVWNDSQITAHPAIIPTRHTFDMTKLTADELKVYQLIRHYYLAQFLPAQETDVTDVTFTIGGQVFQAKGRVSVVTGWKALFADEKQAQEQEDNTALPALKKEEISPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRESAGLGTEATRAGIIEALFKRRLLARKKKNLHATQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRRGNSPD
(1717) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
4
MQLYLCEKPSQARDIARVLGVKQRGQGYLFGDSIIVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCHFTGPVRRLWLSALDETSIRQALAAILPGEKTAPLWQAGLGRARADWLTGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMATLQKDDISFRAKWLPAPDDGDEEKRCIREDIAQSVVQRCQQTQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYETHKATTYPRTDCGYLPVSMRENIPAVFTALTRTDPAMSAIISQLDASAFSRVWNDSQITAHPAIIPTRHTFDMTKLTADELKVYQLIRHYYLAQFLPAQETDVTDVTFTIGGQVFQAKGRVSVVTGWKALFADEKQAQEQEDNTALPALKKEEISPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRESAGLGTEATRAGIIEALFKRRLLARKKKNLHATQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRRGNSPD
(50) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSIIVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILPGEKTESLWQAGLGRARADWLMGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVVATLQKDGIGFRVKWLPAPDDCDEEKRCIKEDIAHSVVQCCQEAQNAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDASTLSRVWNDSQITAHHAIIPTRHPFDMTKLTADELKVYQLIRQYYLAQFLPAQETDVTDVTFTIGGQVFQATGRVSVVTGWKALFADEKQAQDQDGNTALPVLKKAETCPVIRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEALFKRRLLARKKKNLHATQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRRGNSPD
(1671) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAAETGRQTE
(284) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1883) DNA topoisomerase 3 [Salmonella bongori NCTC 12419]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWSLADLPIVPEKWQLQPRPSVTKQLNVIKRFLQDAGEIVHAGDPDREGQLLVDEVLDYLQLPAEKRQRVQRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMKAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYALIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPIVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVRQFRGIIAPVGEGKKKSAPRKRPAKKSPPQA
(844) DNA topoisomerase 1 [Salmonella bongori NCTC 12419]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGDALPLQVTHQNDKPFRPVSREQTLAAISLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVSVMAESLKDMEADAQKLYQLIWRQFVACQMTSAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKSDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVIRFSRKTKQQYVAAEKEGKATGWSAFFVDGKWVEGKK
(743) DNA topoisomerase [Serratia plymuthica AS9]
4
MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPWRESVLPIVPTQWKMAIKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHFTGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAREQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRGTLQKGGIAFPANWVPAANYCDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMSANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRAFVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEATFNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELKTLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYLEKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGHLVEKGKTQAVKFTAPPSPPCPTCSGSMRRRAGKKGGGAFWGCSNYPTCQGVINIDAKGGRKAKRYKAKSPTKNKATGSE
(369) DNA topoisomerase 3 [Serratia plymuthica AS9]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGNNDVVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNAIKKLLHDADEVVHAGDPDREGQLLVDEVLDYLALTPEKRHSVRRCLINDLNPQAVERAIDRLRDNRDFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVPKDFFEVKAHIVTPKEERFVALWQPSDSCEPYQDEEGRLLHRPLAEHVLKRIEGQPALVTSYNDKRESDTAPLPFSLSTLQIEASKRFNLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISAHQPDLYPQPVIDSDRRNRCWDDKKVDAHHAIIPTARASKVSLSQDELNVYGLVARQYLMQFCPDAMFRKCVIELDIAGGKFVAKARFLAEAGWRTLLGSKERDEENEGSPLPVVAKDDELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIELLFKRAFLYKKGRYIHSSETGRALIHSLPDIAARPDMTANWEATLTQISEKSCRYQDFMQPLVGTLQELIYQAKQSRASMAFRGLPPSPSAGAKKRKKSAGKAREKSE
(1540) DNA topoisomerase 1 [Serratia plymuthica AS9]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTEDKAKKKVKKDEKTALVNRMGVDPYHGWKADYEILPGKEKVVAELKSLAENADHIYLATDLDREGEAIAWHLREVIGGDEKRFSRVVFNEITKNAIQQAFKQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKNDTALQMEVTHAHDKPFKPVNREQTHAALKLLEKARYTVLDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGDNFGDKYLPKAPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLSVKAGDYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPYVEVGSDLELQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEENFRELMNYDFTARMEDGLDQVANNHAEWKAVLDEFFAEFSEQLETAEKDPEDGGMRPNQMVMTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPETEVLNILEGDDAETNALRARHRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEEGEFRLKGYDGPVVECDKCGSEMHLKMGRFGKYMGCTNETCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADGEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(1816) DNA topoisomerase 3 [Shigella boydii Sb227]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTRQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA
(1810) DNA topoisomerase 1 [Shigella boydii Sb227]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(310) DNA topoisomerase 3 [Shigella flexneri 5 str. 8401]
10
MANWCQRAAVVPWLRSVNLMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIA
(1024) DNA topoisomerase 1 [Shigella flexneri 5 str. 8401]
9
MRRIPGRIKLGKVNMGKALVIVESPAKAKTINKYLGCDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(366) DNA topoisomerase 3 [Yersinia enterocolitica subsp. enterocolitica 8081]
10
MMRLFIAEKPSLARAIADILPKPHRRGDGFIACGSDNMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWRLQPRPSVSKQLNVIKQLLQQADEVIHAGDPDREGQLLVDEVLDYLDLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRIAGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISMHQADLLPLDVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKQNRSPQVFRGLPAAPSGAIKKRKKTSSKTKENKS
(1742) DNA topoisomerase 1 [Yersinia enterocolitica subsp. enterocolitica 8081]
9
MGKALVIVESPAKAKTINKYLGNNYVVKSSVGHIRDLPTSGSASKKSANSTEDKAKKADKPKTKVKKDEKVALVNRMGVDPYHGWKAQYEILPGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKGEVPIQMEVTHAHNKPFKPVNREQTHAALKLLENARYKVLDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPSAPNQYSSKENSQEAHEAIRPSDVNVMAEQLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSELDLQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESGLDQVANDQAEWKAVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVMTSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEAEILNILEGDDAETNALRAKRRCQKCGTAMDSYLIDNQRKLHVCGNNPTCDGYEIEEGEFRIKGYEGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVTDNEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEAKK
(323) DNA topoisomerase 3 [Yersinia pestis A1122]
10
MRLFIAEKPSLARAIADILPKPHRRGDGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPVGPSGAPKKRKKISSKAKESKS
(1303) DNA topoisomerase 1 [Yersinia pestis A1122]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSANSAEEKAKKDDKPKKKVKKDEKVALVNRMGVDPYHGWKAQYEILSGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNISRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLVAKGDIPIQMEVTHAHGKPFKPVNREQTHAALTLLENARYKVLDREDKPTSSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPATPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQRLYQLIWRQFVACQMPPAKYDSTTLTVQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSDLDLQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESGLDQVANDQAEWKAVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVMTSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPDAEILNILEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEAGEFRIKGYEGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLLELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVVDKEGNKTLVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEAKK
(1001) DNA topoisomerase 3 [Yersinia pestis]
10
MMRLFIAEKPSLARAIADILPKPHRRGDGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTACASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPVGPSGAPKKRKKISSKAKESKS
(1798) DNA topoisomerase 3 [Yersinia pestis]
10
MRLFIAEKPSLARAIADILPKPHRRGDGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPVGPSGAPKKRKKISSKAKESKS
(490) DNA topoisomerase 3 [Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGDNQFVTWCIGHLLEQAEPDAYDSRFARWSLVDLPIVPEKWQLKPRPSVAKQLDIIQELLKKADEVVHAGDPDREGQLLVDEVLDFLNLDGEKRKNVRRCLINDLNPQAVAKAVDRLRDNRDFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYRGVLSVGRVQTPVLGLVVRRDEEIEHFVPKDFFEVKAHIVTPKDERFTAIWQPSESCIDFQDEEGRLIHRPLAEHVVARITGQPAYVTSYQDKRESEVAPLPFSLSSLQIEAAKRFGLNAQQILDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISVHTINLLPQDLLEVDRKNRCWDDKKVDAHHAIIPTARNSHINLTDNEANIYGLIARQYLMQFFPDAIFRKCVIELEIAGGKFIAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKGDELLCERGEVVDRQTQPPKPFTDATILSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKREFLYKKGRYIHATPAGRALIHVLPDIAALPDMTAHWESRLTQISEKQFRYQDFMKPLEETLQQLIWQAKQSRNLQAFRDLPPVPVKGKNGKKSKSGKNTKATAP
(1696) DNA topoisomerase 1 [Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSASQKSSSSSTDKSKKKVKKDEKAALVSRMGVDPYRGWEANYQILPGKEKVVAELKSLAEKADHVYLATDLDREGEAIAWHLREVIGGDSDRFSRVVFNEITKNAIKQAFDKPGELNIDRINAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWQLHADLLAKGEISLHMEVTHKRGKPFKPVNSEQTQAAVSLLEKARYKVVDREDRPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALDMVRGYISDNFGDKYLPKTANTYSSKENSQEAHEAIRPSSVDVMAEQLKDMDADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFELRAKGRTLRFDGWTKVMPALRKGDEDHTLPVVEVGTELDLQQLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYSEKMGEIVTDRLEENFNELMSYDFTARMEDQLDQVASNKAEWKGVLDEFFTDFSEQLEVANKDPEDGGMRPNPMVITSIACPTCDRPMGIRTATTGVFLGCSGYALSPKERCKQTINLIPENEILNILEGDEAETNALRARRRCKKCGTAMDSYLIDNQRKLHVCGNNPACDSYEVEEGEFRIKGYDGPVIECDKCSSEMHLKMGRFGKYMGCTNETCKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADAEGNKTVIRFSRKTKQQYAASEKNGKATGWSVFYVDGKWIEKDKK
(147) DNA topoisomerase 3 [Citrobacter rodentium ICC168]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLSDLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEVVHAGDPDREGQLLVDEVLDYLQLAAEKRQQVQRCLINDLNPQAVERAIERLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFIPKDFFEVRAHIVTPADERFIAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPAFVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIGVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSTINLSENEAKVYNLIARQYLMQFCPDAVFRKCVIELEIAKGKFIAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKSTPVRRFRGIVAPGGGSSEKKKSAPRKRAAKKSPPSAEAGL
(1777) DNA topoisomerase 1 [Citrobacter rodentium ICC168]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGDALPLQVTHQNDKPFRPVNREQTQAAVSLLEKARYTVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDSFGKKYLPDSPNQYASKENSQEAHEAIRPSDVTVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLVELIPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHEAEWKAVLDNFFSDFTQQLDKAEQDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVAAEKDGKATGWSAFYVDGKWVEGKK
(814) DNA topoisomerase 1 [Buchnera aphidicola str. Ua (Uroleucon ambrosiae)]
1
MSKSLVIVESPAKAKTINKYLGNEYIVKSSIGHVRDLITRKFKKPTHKSQKYSQSYSLNNKQKTYFIENIGIDPYKDWKAEYSILPGKEKIISELKNIAHKVDHIYLATDLDREGEAIAWHLKEVIGGDSTKFSRVVFNEITKHAIKKAFKNITKINMHRVHAQQARRFMDRIVGYMISPLLWEKISRGLSAGRVQSVAVRIIAEREDIIKKFIPEEYWKLNVSFVLKNQNKIIMDVTHFNNKKFRPNNQNELNIAIEEIKKSSFFIKKFEKKIIYKQAPAPFITATLQQSASLILGFSVKKTMFLAQKLYEEGYITYIRTDSCYLSLNAINKVRKYIKKFYGDAYLSNKYYIHTNKKHSQEAHEAIRPSDIKVKNINTNTINLDAEKLYLLIWNQFIASQMKPAQYQFITIKIFSHLFQLQKQLKIVLFDGWTKMFKEKNENITQIPIIDIGSILNIDNIIINQKFTKPLPRFTEASLVRELEKKGIGRPSTYSVITSKIQERGYVTIKKNKFYAEKMGSILTIRLKKSFSNLIDYNFTANMEKKLDQIAENKLSWINVLNSFFKDFSEKLDQAKKNPEEGGMELNNIVFTSIKCPTCFKKMGIKNAITGVFLSCLGYQDNLKKRCKQTINLIPLNDVLKKKQNNEVTSGFTKLINKCEKCNMFMDSYFINKNIQLHICINNPSCIGYKVEKGNFKIPIWLSKTVECDKCYSNMLLKKGPFGKFFICVNIKCKNTRKILPNGEISDPKLEPIPFPELLCKKSNASFVLREGVSGIFFAASTFPKSRETRSPFIEELAKFQYLLPKKIYYLSKAPIVDDKGNKTIVCFNRKNKEYYVTSKKKGKFTGWSAVFIKNKWCVINQ
(198) DNA topoisomerase 1 [Candidatus Vesicomyosocius okutanii HA]
1
MAKNLVIVESPTKAKTIEKFLGKDFSVKSSIGHIRDMPKKNMGIDIDNNFTPTYEITADKKKVVTDLRKAVKVAEKVYLATDEDREGEAIAWHLLEALNLPKDTPRIVFHEITKNAITHAISEPRIVNYRLVDAQQARRIIDRLVGFEISPILWRKISGARSAGRVQSPVVRLVVEREREISKHIDNSTYKVKAELSSESGEIFKVKLSKEFKSKKQVLAFANILLLANLTITSIEKKPFKRSPKPPFITSTLQQEAFQKLGFSVKQTMILAQNLYRKGFITYMRTDSFILSETAIEAVHKIIVREFGSEYHNTRRYKSKESRAQEAHEAIRPTDLTRSNIFDIEEQAAKLYILIYKRTLSCQMSDAQLQKTKIKINIEGLDEIFIANGEVLVFPGFLRIYDYLLSEDKLLPRLNKGNALNLVNFKARESFSRAKPRYTEASLVKKIEEMGIGRPSTYSTMVSTVQDRNYVTKKNGRGVEREYQLIEIKDNQVIQSQPSEVISGEKNKLFPTNIAYLLTDFLVKYFNNIIDYKFTAKLESDFDTIATQNISWQGVVKNFYIPFHQKIEDAVNISREEIHSMRNLGVDPKSDKPVSVRVGRYGAFVQIGHTDDKDKPTFASFRGLLDIESITLDEALELFNMPRHLGETDNFGTIKANYGRFGPYIQYGKKYVSLKEDIPEEVSLEKALELIKIKEKFDSERIIKIFDGSDIQLLNGRFGPYIWNGKKKGKGQKNITIKKVFGDKPIANLTLEECKKAISGKLKLKKKIVKKEVTKNS
(1021) DNA topoisomerase 3 [Rahnella sp. Y9602]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGNDQVVTWCVGHLLEQAQPDAYDSRFARWSLADLPIIPEKWQLQPRSSVAKQLNVIKRLLLEASQVVHAGDPDREGQLLVDEVLDYLELTPEKRHATQRCLINDLNPQAVERAIERLRDNRDFIPLCVSALARARADWLYGINMTRAYTILGRNAGYNGVLSVGRVQTPVLGLVVRRDEDIENFVPKDFFEVKAHIVTPAEERFVALWQPSDSCEPYQDEEGRLLHRPLADHVVARIAGQPAMVTGYNDKRENDIAPLPFSLSTLQIEGSKAFGLSAQQILDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAIGVHRPDLMPQPAVDTDLRNRCWDDKKVDAHHAIIPTARSSNVNLTDDERKIYGLVARQYLMQFCPDAVYRKCVIDLDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGTPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFRREFLYKKGRYIHSSDTGRALIHSLPDIAARPDMTADWESTLTRISEKSCRYQDFMQPLVATLQNLIMQAKTNRVSSAFRSLPSKPAGAVAKGKSAPKRRKASTKGKEANSDE
(936) DNA topoisomerase 1 [Rahnella sp. Y9602]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKTADSTEEKTKKKVKKDEKTALVNRMGVDPYHGWEAQYEILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQNAFKEPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLLAKKETALQMEVTHHLEKPFKPVNKEQTHAAVSLLEKARYTVVDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVEMVRGYIGENFGDKYLPKAPLQYSNKENSQEAHEAIRPSDVAVISEQLKDMEADAQRLYQLIWRQFVACQMTPAQYDSTTLTVKAGDYSLRAKGRTLRFDGWTKVMPALRKGDEDRTLPAIEVGTDLELQQLLPTQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVHVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMEDGLDQVANNKAEWKAVLDEFFTEFSKQLETAEKDPEEGGMRPNQMVLTSIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLIADAEVLNILEGDEAEANALRAKRRCVKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELKRFKDRLPEKLSYLADAPVADPEGNKSMVRFSRKTKQQYVSSEKDGKATGWTAFFVDGKWVEGKK
(418) DNA topoisomerase 3 [Rahnella aquatilis CIP 78.65 = ATCC 33071]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGNDQVVTWCVGHLLEQAQPDAYDSRFARWSLADLPIIPEKWQLQPRSSVAKQLNVIKRLLLEASQVVHAGDPDREGQLLVDEVLDYLELTPEKRQATQRCLINDLNPQAVERAIERLRDNRDFIPLCVSALARARADWLYGINMTRAYTILGRNAGYNGVLSVGRVQTPVLGLVVRRDEDIENFVPKDFFEVKAHIVTPAEERFVALWQPSDSCEPYQDEEGRLLHRPLADHVVARIAGQPAMVTGYNDKRENDIAPLPFSLSTLQIEGSKAFGLSAQQILDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAIGVHRPDLMPQPAVDTDLRNRCWDDKKVDAHHAIIPTARSSNVNLSDDERKIYGLVARQYLMQFCPDAVYRKCVIDLDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGTPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFRREFLYKKGRYIHSSDTGRALIHSLPDIAARPDMTADWESTLTRISEKSCRYQDFMQPLVATLQNLIMQAKTNRVSSAFRSLPSKPAAAKGKSAPKRRKASTKGKEANSDE
(1587) DNA topoisomerase 1 [Rahnella aquatilis CIP 78.65 = ATCC 33071]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKTADSTEEKTKKKVKKDEKTALVNRMGVDPYHGWAAQYEILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQNAFKEPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLLAKKETALQMEVTHHLEKPFKPVNKEQTHAAVSLLEKARYTVVDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVEMVRGYIGENFGDKYLPKAPLQYSNKENSQEAHEAIRPSDVAVTSEQLKDMEADAQRLYQLIWRQFVACQMTPAQYDSTTLTVKAGDYSLRAKGRTLRFDGWTKVMPALRKGDEDRTLPAIEVGTDLELQQLLPTQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVHVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMEDGLDQVANNKAEWKAVLDEFFTEFSKQLETAEKDPEEGGMRPNQMVLTSIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLIADAEVLNILEGDEAETNALRAKRRCVKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELKRFKDRLPEKLSYLADAPVADPEGNKSMVRFSRKTKQQYVSSEKDGKATGWTAFFVDGKWVEGKK
(1002) DNA topoisomerase [Halothiobacillus neapolitanus c2]
4
MRVYLCEKPSQARDIAAVLGIQSKDKSSITTADGVVTWAFGHLLEQAPPDAYDDSLKRWALASLPIAPTQWKVEVKSSAKDQFKAIATLLKRATEVVIATDADREGEMIARELMAFVGFKGKVQRLWLSALDAASVKKALAALKPSAETAGLYQSALGRSRADWLVGMNLTRAFTLAGCSQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFFEAGQSFSTKWKVPEGAGDDAGRCVDQSIVDAVASKITGKTGTVSQYETKRISENPPLPFSLSTLQKTCSAKFGLGAQEVLDIAQALYETHKATTYPRSDCNFLPEEQFQEASSIVTALAKSDTEVQGIVDLLDFSRKSPAWNTKKITAHHAIIPTQTPPNMDAMSDNERRVYELIRRQYLAQFLPNYEYDRTQIGISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLPALTQGQTLPLSHTEIAAKQTKPPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTEATRAGIIANLIERGFITKKGKQVISSDVGRQLIDALPDSVKSPALTALWEQSLEEIAEGKRELAGFEADVVKFITAIIDQIKKQHADAPAPTRPTADCPTCKAQGQAEKVYSIKKQCHYWHCKACNQWFDDAAGKPVPKAAASSSKTKPAPRKKTTARKAK
(1231) DNA topoisomerase 1 [Halothiobacillus neapolitanus c2]
1
MSQTLVIVESPAKAKTIKKYLGPGYEVLASYGHVRDLIPKDGAVDTAHDFAMNYTLIDKNVRHVDAIKKALKSSDILLLATDPDREGEAISWHLRELLAEAGLLKNKTAQRVVFYEITKKAVQEAVAHPRDLSIDLINAQQARRALDYLVGFNLSPLLWKKINPGLSAGRVQSPALRLIVEREAEIEAFNPQEYWTILADCQADRAAEKSRFNARLLTLDGQKAEQFTLTNETDAQSARSRILEAAAGTLTVRSVEKRERKRNPAPPFTTSTLQQEGVRKLGLSASRVMRLAQELYEGVDIGAGTVGLITYMRTDAVTLSEDALTQIRAHIGDKYGAAYLPASPNRYKTKSKNAQEAHEAIRPTSAAHTPDSVRAFLNKDQFRLYEMIFKRAVASQMTPAVYDQVSVDLAVNDQHSFRANGSTLKFPGFIALYREDEDDASGDNDEDRRLPPLTVGDKIALNDIAADQHFTEPPPRFTEASLVKTLEEYGIGRPSTYASIISTLQAREYVLLDQRRFKPTDMGRVVNGFLTDYFRDIVDYEFTAKLEDDLDAVSRGERDWVPLMREFWTPFHDRVEHTNENVTRQEAAQGRELGIDPKSGKPVSVRLGRFGPFAQIGTKDDEEKPKFASLKRSQSIATITLDEALDLFQLPRKLGETPEGEPVEVAIGRFGPFVKFGKMYASLGKDDDPYTIELPRALEIIEIKKLAEKNRYITQFDNGVSVQNGRYGPYITDGKKNAKIPKDKDPKSLTLEECVALLAAAPEKKSARGKTAAKATAKKTAAPKATAPKTTAKKSTTPRAKKASATDAQAPAKKTPVKKPATARSKKPAATIPE
(1337) DNA topoisomerase 3 [Pantoea ananatis PA13]
10
MRLFIAEKPSLGRAIADVLPKPHRRGEGFIACGNDQIVTWCVGHLLEQAQPDVYDSRYARWSLVDLPIIPEKWRLQPRPSVAKQLKVVEGLLAQADEVVHAGDPDREGQLLVDEVLDYLQLPAEKRSKVQRCLINDLNPQAVERAINRLRENREFIPLCVSALARARADWLYGINMTRAWTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIANFVPKDYFEVKAHIVTPDESRFTANWIPSEACEPWQDEEGRLLKRSLAEHVVARISGQPAIVTAYSDKRENDIAPLPFSLSSLQIEAAKRFGLSAQAVLDICQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAIQSHQPDLTPPADFDADRKNRCWDDKKVDAHHAIIPTARASAVKLNENEQQIYGLVARQYLMQFCPDAVFRKCTIDLDIAGGKFVAKARFLAEAGWRALLGGKERDEENDGMPLPVVAKDDELLCERGEVLAKQTQPPRHFTDATLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFRRSFLHKKGRYIHSTDAGKALIHSLPDLAARPDMTAQWESTLTRISEKACRYDEFMQPLVQTLSGLIQQARQQPSGQAFRGLPSTGQKRPPRKAGRKTKETE
(130) DNA topoisomerase 1 [Pantoea ananatis PA13]
9
MGKALVIVESPAKAKTINKYLGSGYVVKSSVGHIRDLPTSGSTAKKSAETSTDKKVKKVKKDEKAALVSRMGVDPYHGWEADYQILPNKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIRQAFDTPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELSANLTTPKGDDLAMDVTHAGDKPFRPVNHEQTHAALALLEKARFAVTDREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVSMVRGYIEGNFGKKYLPDNANTFASKENSQEAHEAIRPSDVDVVAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVTAGDYKLKAKGRTLRFDGWTKVMPALRKNDEDRTLPPVNVGDELSLQALLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYAAIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMESSLDQVANNQAEWKAVLDRFFSDFSQQLEQAEKDPEEGGMQPNQMVLTTIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCQKCGTAMDSYLIDNGRKLHVCGNNPECDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFHDRLPEKLKYLAEAPATDPEGNKTLVRFSRKTKQQYVASEKEGKATGWSAFYIDGKWQEAKK
(1818) DNA topoisomerase [Pantoea ananatis PA13]
4
MRLFLCEKPSQGRDLAAVLGASRRGEGFMTGNGVTVTWAVGHLLETAPPEVYGQQYGKPWSLSALPILPSRWQVVVKKDTQDQFKVIEKLLRQADEVVIATDADREGEVIARELLDYCGWDGRILRLWFSALDELSVRAALSDLRPGQASVGMYHAGLGRSRADWLIGMNLSRLYTLRAAEAGFEGVVSVGRVQTPTLALVARRDREIAAFVPKPYWQVKATLSASGVSFQASWVPAAVYADEEKRCIHQNIAQQVAQLCRQAGVSTVTEYETKREKEAAPLAFSLGTLQRACGKMWNMSPQKVLDTAQSLYETHKATTYPRTDCGWLPKSMREEIPAVFDAMARTDPSPEFASLLSQLDRGFASRIWNDKKITAHHGIIPTRNAVQLSSLTETERQVYLLIRRNYLAQFLPLCESDATRISFDIGGQLFRTTGRTEVLKGWKVLFTKDEEDKDTAEEDIAGSLPPLSKGAQCGVTDAEVKQLMTQPPAHYTFDTLIGAMMNAAAYVTDLQLRKILKENAGLGTEATRAGIIEQLLSRRFITLKGSKLLATDLGADVIDALPPQLTDPGMTALWEQALDEVAAGRMNLNDFLQRQTAWTSTLVSQGMQQRISIRVPPSPPCPLCGSKTALRRSPKGEFRSCTRYPECKGIISLDSGRRKSPARAKSPKTKKN
(536) DNA topoisomerase 3 [Pantoea sp. At-9b]
10
MRLFIAEKPSLGRAIADVLPKPHRRGEGYIACGNDQVVTWCVGHLLEQAQPDSYDSRYARWNLADLPIIPEKWQLQPRPSVAKQLKVIEGLLAQATEVVHAGDPDREGQLLVDEVIDYLQLPAEKRQKVQRCLINDLNPQAVERAVSRLRENREFIPLCVSALARARADWLYGINMTRAWTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFIPKDYFEVKAHIVTPKDERFVASWVPSDACEPWQDEEGRLLHRPLADHVLERINGQPARVTAYNDKRESEIAPLPFSLSSLQIEAAKRFGLSAQNVLDCCQRLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIQAHQPDMTPPADFNPEQRNRCWDDKKVDAHHAIIPTARASKVNLSENEANIYGLIARQYLMQFCPDAVFRKCVIDLDIAGGKFVAKARFLAEAGWRALLGSKERDEENDGTPLPVVSKGDELLCERGEVLAKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFRRTFLVKQGRYIHSTQAGRALIHALPEMAARPDMTAHWESTLTRISEKACRYDEFMQPLVSTLIGLIGQARQQPSLQAFRGIAASGSASEKKRTRKPARRKMKETE
(702) DNA topoisomerase 1 [Pantoea sp. At-9b]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTARKSADGEKTKPAGKKVKKDEKAALVNRMGVDPWHGWQADYQILPGKEKVVSELKSLAADADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIRQAFEKPGELNIERVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDADLVTPKGDALAMQVTHQGDKAFRPVNREQTYAAVALLQKARYDVLDREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAIAMARSYIDKNFGANYLPAAPNTYASKDNSQEAHEAIRPSDVAVAAEKLKDMEADAQKLYQLIWRQFVACQMVPAQYDSTTLTVGAGDFKLKAKGRTLRFDGWTRVMPALRKNDEDLTLPPVNVGDVLDLKEVLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDSLDQVANNQAEWKGVLDSFFSDFSQQLDQAEKEPEEGGMQPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNVLEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEQGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFADRLPEKLKYLAEAPAADPEGNKTMVRFSRKTKQQYVASEKEGKATGWSAFYVDGSWQEAKK
(535) DNA topoisomerase 1 [Alkalilimnicola ehrlichii MLHE-1]
1
MSKNLVIVESPAKAKTINKYLGKDYKVLASYGHVRDLVPKEGAVDPEHGFAMKYTTIDKNAKHVDTIAKAMKQADALYLATDPDREGEAISWHLYELLKEKGALKDKPVYRVVFHEITPRAIREAMEHPRELSTPLINAQQARRALDYLVGFNLSPLLWKKIATGLSAGRVQSPALRMIVEREEEIEKFISREYWTVEADLARNGEAFPGRLHTLDGQRVKQFDIDNGERAREVEHQLARAAGMALSKSHIDAGEGESPVQSPGTVQVTQVEKKQRRRNPAAPFTTSTLQQEAARKLGFTANRTMRVAQQLYEGIDIGGGVTGLITYMRTDSVNLSQEAVADLRDTIAKRYGEDRLPKAPQVYRTKSKNAQEAHEAIRPTGAFRLPEEVRGKLSDDQFRLYELIWKRAVACQMIPALINTVAVDLACGEGNSFRATGSTIAEPGFMAVYLEGTDDRKPDVGSSERILPPLKEGDKVALERIKPEQHFTEPPPRYTEASLVRALEEYGIGRPSTYAAIISTLQQRKYVELDGKRFRPTDIGRVVNRFLTDHFDRYVDYDFTARLEDDLDAVSRGERDWVPLLEEFWQPFKDKVDEKATISREEVMQSRDLGTDPKTGKPVSVRVGRFGPFVQLGTKDDEEKPRFAGLRPGQSMDKITLEEALELFKLPRDMGETPEGEPMQVNIGRFGPYVRFGNKFVSIKDDDPYTISRERCLELVEEKKRIERERTIRDFEGSDIRILKGRYGPYITNGKKNARIPKDREPESLGLEECEELIAKAPERKGRRRTGGTGRKRSTKA
(715) DNA topoisomerase 3 [Pantoea vagans C9-1]
10
MRLFIAEKPSLGRAIADVLPKPHRRGDGFIACGNDQIVTWCVGHLLEQAQPDSYDSRYARWSLNDLPIIPEKWQLKPRPSVAKQLKVVEGLLAQASEVVHAGDPDREGQLLVDEVLDYLNLPPEKRSKVQRCLINDLNPQAVDRAVNRLRENREFIPLCVSALARARADWLYGINMTRAWTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFEVKAHILTPDGARFVASWIPSEACEPWQDEEGRLLKRALADHVVARITGQPAIVTAYSDKRENDVAPLPFSLSSLQIEAAKRYGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPEEHFAGRRTVLKAIQAHQPQLTPPADFNADRRNRCWDDKKVDAHHAIIPTARSSAVKLSENEQHIYELVARQYLMQFCPDAVFRKCVIDLDIAGGKFMAKARFLAEAGWRALLGSKERDEENDGMPLPVVAKGDELLCERGEVLAKQTQPPRPFTDATILSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFRRGFLVKKGRYINSTDAGRALIHSLPDLAARPDMTAQWESTLTRISEKACRYDEFMQPLVQTLTGLIQQARQQPAAHAFRGLPSTGQKRPVRKTRRKVKETE
(582) DNA topoisomerase 1 [Pantoea vagans C9-1]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSTAKKSADASTDKKVKDASTDKKVKKVKKDEKAALVSRMGVDPYHGWEADYQILPGKEKVVAELKALAANADHIYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVNAALTTPKGDELSMDVTHKGDKAFRPVNRDETYAAVALLEKARYEIVDREDKPTSSKPGAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVAMARGYIESNFGKKYLPETAITYASKENSQEAHEAIRPSDVEVVAEKLKDMEADAQKLYQLIWRQFVACQMTPAKYDSSTITAAAGEFKLKAKGRILRFDGWTKVMPALRKNDEDRTLPAVSVGDVLDLQQLLPGQHFTKPPARFSEASLVRELEKRGIGRPSTYAAITSTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESNLDQVANNEAQWKAVLDHFFADFTQQLELAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCQKCGTAMDSYLIDNERKLHVCGNNPECDGYEIEKGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRSGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFKDRLPEKLKYLADAPAADPEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWQEAKK
(885) DNA topoisomerase 1 [Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum)]
9
MGKSLVIVESPAKAKTINKYLGSHYVVKSSVGHIRDLPKSGSNNKKNASEIIKKQKTEKKMFQDHQSSLIKRMGIDPYHGWKAQYEILSGKEKVVSELKALAAKADHIYLATDLDREGEAIAWHLREVIGGDPQRFSRVIFNEITQNAIQQAFKKPGELNMNRIHAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPQEYWHLEANLLTPQKIMIPMMVSHFEGEPFKPLNREQTYAAVNDLEDAQYVVLDRKDKPTSSKAGAPFITSTLQQAASTRLGFGVKKTMLMAQRLYEAGHITYMRTDSTHLSQDALSMVRNYIQKHFGNRYLISPAYEYGNKKNAQEAHEAIRPSNVDVFSEQLEDMEPDARKLYQLIWRQFVACQMTPAQYDVTTLIVEAKNYQLRAKGRTLRFDGWTKVMPALRKGDEEETLPIIAVGTSMHLEKLIPSQHFTKPPGRYSEASLVKELEKRSIGRPSTYATIISTVQERGYVRIENRRFYAEKMGEIVTNRLEENFRELMNYDFTARMENALDQIAQHQAEWKKVLDEFFSEFSEQLNIAEKDPSEGGMRPNSMVIMDINCPACGQKMGIRTASTGVFLGCSSYALPPKERCKTTLNLISENEILNLLDGDEAETNALRSRRRCEKCETAMDSYLLDTARKLHICGNNPICDGYQMEQGEFRIKGYEGPIVECDKCAHEMHLKVGRFGKYMGCTNEECKNTRKILRNGEVAPPKENPVPLPELLCEKSDAYFVLRDGAAGLFLAANTFPRSRETRAPRVEELQRFKDRLPEKWHYLVEAPLKDTEGNKTFLRFSRKTKEQYISSEKSGKATGWCAFYIDGQWVEGKKRPLVKS
(1163) DNA topoisomerase 3 [Escherichia fergusonii ATCC 35469]
10
MPWLRFVKSMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDTYDSRYARWNLTDLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNNKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRCIVAPDGGEGNKKTSSRKRAAKKSPPADEAGSGAIA
(1194) DNA topoisomerase 1 [Escherichia fergusonii ATCC 35469]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANTTTPSGDALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPAGNKSMVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEGKK
(824) DNA topoisomerase 3 [Escherichia coli NA114]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETYKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTSVRQFRGIMAPGGGEGKKKDSPRKRAPKKSPPSEEAGNGVII
(307) DNA topoisomerase 1 [Escherichia coli NA114]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(1300) DNA topoisomerase 3 [Cronobacter turicensis z3032]
10
MRLFIAEKPSLGRAIADVLPKPHRRGDGFIECGNGQVVTWCVGHLLEQAQPDAYDSRYGRWNLADLPIVPEKWQLQPKPSVAKQLNVIKKLLREAQEIVHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDKLRENREFVPLSTSALARARADWLYGINMTRAYTLLGQNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFVAKDFFEVKAHIVTPAQERFTALWQPSEACEPYQDEEGRLLNRALAEHVVKRIEGQPARVTSYNDKREGEAAPLPFSLSTLQIEASKRFNLSAQAVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLKAIGVHASDLLPQPAVDPERRNRCWDDKKVDAHHAIIPTARSAPASLSDGEAKIYGLIARQYLMQFCQDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGAKERDEENDGTPLPVVAKGDELHCERGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLEKQGRYIHSTPAGKALIHALPELAARPDMTAQWESTLTQISEKQCRYQDFMQPLVHTLYTLIDQARSAPVRQFRGLVAPQQAQKRRAGKGGKKPAARKRSGAQPATE
(1760) DNA topoisomerase 1 [Cronobacter turicensis z3032]
9
MGKALVIVESPAKAKTINKYLGKDFVVKSSVGHIRDLPTSGSAPKKSAESAPTKPAKKVKKDERGALVNRMGVDPWHNWEAQYEVLPGKEKVVSELKSLAEKADHIYLATDLDREGEAIAWHLREVIGGDETRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDALLSTPKSDQLSVQVTHHKDKPFRPVNRQDTEAAVALLKAASYQIVEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVSMVRNYIGEEFGKKYLPENPNQYASKENSQEAHEAIRPSDVSVLAESLKDMENDAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFRLKARGRILRFDGWTRVMPALRKGDEDRTLPAVNQGDKLSLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFPELMNFDFTAQMEDSLDQVANHEAEWRGVLDTFFDDFSRQLDTAEKDPEEGGMRPNQMVLTSIDCPTCGRPMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEVEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFRDRLPEKLLYLADAPAQDPEGNPAVVRFSRKTKQQYVASEKDGKATGWSAFYVDGKWAEGKK
(1411) DNA topoisomerase 1 [Candidatus Moranella endobia PCIT]
9
MGTALVIVESPAKAKTINKYLGKGYVVKSSVGHIRDLPKKSPASKNKNNTCIPDQHTVLIKRMGIDPFHSWKARYEILPGKEKLVTELRALAEEADHVYLATDLDREGEAIAWHLREAIGGDEKRFRRVVFNEITRNAVTQAFENPVVLNMNRVNAQQARRFMDRIVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKSFMPAEYWELHVALQTSQAAQLMMKVTHQQEKPFKPAKQQQLQAAISILEHTDYIVSNRDDKITTSKPGSPFTTSTLQQAASLHLGYRVKKTMLLAQRLYEAGHITYMRTDSTHLSRNALNMARCYISAAFGHSYLPTQPKEYVSKNNSQEAHEAIRPSDVSALAEQLNNMEAEAQKLYQLIWRQFVACQMKPAQYNYTILTVNAGEFQLSAHGRQLMFDGWTKVMPTQHTEKDKRTLPTVKEGNNLTLNKILPSQHFTKPPARYSEASLVKELEKRGIGRPSTYVSIISTIQERGYVHADNRRFYAEKIGEIVTDRLEENFSELMSYDFTAKMEATLDQVATNQQDWKSVLDAFFSKFSQQLKNAEQNPVDGGMRLNQMIMTSINCLVCDRPMGIRTASTGVFLGCSGYQLPPKDRCKNTIHLIPESETLNRFTVGDEETNALRARRRCVKCRTAMDNYVIDSKRKIHVCGKNPLCDGYNIEQGEFIVVAYNGRVVECEKCGFNMQLKFGRFGKYIACTNNNCKNTRKILRNGDVAPPKEDPVLLPELPCYGHSDAYFVLREGAVGVFLAANTFPKYRETRKPLVAELARFRERLPVKLQYLADAPIEDDEGNSTLVRFSRKTKQQYISSEKDGKATGWTAFYVNGKWQVNRKSSGCGP
(462) DNA topoisomerase 3 [Enterobacter cloacae EcWSU1]
10
MRSVNSMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLNDLPIVPEKWRLQPRPSVTKQLNVIKRFLHDATEVIHAGDPDREGQLLVDEVLDYLELAPEKRQQVQRCLINDLNPQAVERAISRLRANSEFIPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPKDERFTAVWQPSDACESYQDEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESEPAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHSVMNAIAVHAPDLLPQPVVNPDIHNRCWDDKKVDAHHAIIPTARASNVNLTENEAKVYNLVARQYLMQFCPDAVFRKCVIELEIAKGKFIAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLEKKGRYIHSTEPGRALIHSLPELAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYELINQARNTPVKQFRGMVAPGGAPKKPFKKKKSAA
(542) DNA topoisomerase 1 [Enterobacter cloacae EcWSU1]
9
MNMGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERSALVNRMGVNPWHNWDAQYEVLPGKEKVVNELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANVTTPGGDALPLQVSHQNDKPFRPENRDQTMAAVALLEKARYQVLEREDKPTSSKPGAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPESANQYASKENSQEAHEAIRPSDVSVLAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDELSLVDLVPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEANFRELMNYDFTAQMEDSLDQVASHQAEWKKVLDSFFSDFTNQLEKAEKDPEEGGMLPNQMVLTSIDCPTCGRKMGIRTATTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELHRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKEGKATGWSAFFVDGKWVEGKK
(231) DNA topoisomerase 3 [Vibrio vulnificus YJ016]
10
MTRLFIAEKPSLGRAIAAALPNPQKKEQGFIRCGNGDIVTWCIGHLLEQVEPDAYDERYKKWNMADLPIIPEQWQLRPRPSASKQLTVIRKLLKEASEVIHAGDPDREGQLLVDEVLDYCKLSQTKKAQTQRLLISDLNLPAVKRALSSLRSNRDFVPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPRDFFTLHALIPYQNGSEPFDIKARWKPSEACQPWQDEEGRVLSRKLVENVASRIANQPATVTESEHKQTKQAPPLPYSLSALQIDAAKRYGMSAQQVLDTCQSLYEKHKLITYPRSDNRYLPKEHYAQAASVSQAIANNAKELSDAVSGADLSLKSKAWNDSKVEAHHAIIPTPKQASVNALSGYEMKIYQLIARQYLMQFYPAATYAEAKLVFEIAGGVFIAKGRQLTFAGWKALTGATEKEEDGADTVPPLAKGTVLTCREGVIKDCKTEPPKHFTEATLLQAMTGIARYVSDKELKKILRETDGLGTEATRAGILDTLFKRQLLSRQGKAILSTPAGRGLIHALPQESTYPDMTAHWEHQLQGMAERNQAYQPFMAALQQRISELMQQVTTSPVPSSLRQLPPVERPAFKRKRRASTSKKTASTATQKRTNKSA
(1105) DNA topoisomerase 1 [Vibrio vulnificus YJ016]
9
MGKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTAGQSTGEKAAAISTKGMSVEEKARIKQKKDRNALIKKMGIDPYHDWAANYQILPGKEKVVSELQKLAKDADFVYLATDLDREGEAIAWHLREIIGGDETRYKRVVFNEITKNAIQQAFQKPGHLNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDIHANTLTQETMPFKLLVAQKSGDAFRPVNEAETKAALAVLQKAQFEVCKREDRPTKSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSQEAVEAVRGYISDEFGSRYLPKAPLVYGSKQGAQEAHEAIRPSDVNIKADALEGVDADAHKLYALIWNQFVACQMTEAEYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDTILPAVQVGDKLNLESLEPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEEKLDKIAEGDVNWKDVLNQFFADFTTDLGRAEEDEAHGGMKPNHIVMTDIQCPTCSRPMGIRTASTGVFLGCSGYALPVKERCKTTINLGDEEGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYLVEHGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHFPELPCSNSDAYFVLRDGAAGLFLAASNFPKSRETRVPLVSELARFAERLPEKYKHLAQAPTQDPDGVEAVVRFSRKTKENYVRTEVDGKPTGWTALYVDGKWEVTDKRKNAK
(64) DNA topoisomerase 1 [Baumannia cicadellinicola str. Hc (Homalodisca coagulata)]
9
MNKALVIVESPAKAKTINKYLGNQYLVKSSIGHIRDLPIHRETVKQQGKTNYQNTLANRMGIDPYNNWFANYEILPGKEKLVNELKALANKAKHIYLATDLDREGEAIAWHIREVIGGDNSKFSRVVFNEITCNAITQAFQSPRELNLHRINAQQTRRFMDRIVGYMISPLLWKKIARGLSAGRVQSVAVKLIVEREREIKQFSPIEYWDLYSYLQGPKDIVLKMQVTHLNNKPFKPINSLQVQSAIALLNNARYIVCCREDKITSSNPNAPFITSTLQQAASTRLGYSVKQTMLVAQRLYEAGYITYMRTDSTKISDEAINIVRNYILDIFGSKYLPNQPNQYLSKKNSLEAHEAIRPSNLHILAEQLENIEEDARKLYQLIWRQFVSSQMMPTQYNYTKINVIAGDFQLSTTGRTLHFDGWSKVMPILHKENEESICQSISVGQILSLQQLISQQNFTKPPLRYTEASLVKELEKRRIGRPSTYMSIIDSIQDRGYVKLNNHRFYAKKIGQIVTDRLAENFSELMNYDFTANMEDTLDKVATNQQDWKNVLDTFFIKLNQQLEKAKKSPTEGGMLPNSIVTTSINCPICGRMMGICTANTGVFLSCSGYKLPPKERCKHTINLISESEWLKKLDNENKSIDTQKVRSRCIKCNNIMDSYYFNNNSMLNICNNNPLCDGYEIEQGLCLLNTDYGTLVPCEKCSANMQLRIGRFGKYIACTNNTCKNTRNILRNGDIAPPKMELIEFPELPCKNSNAYFVLRNGAAGVFLAANTFPKVHETRAPLVEELVKFKDRLPTMLRYLTEAPIQDDQGNKTLVRFSRKKKQQYISSEKEGKATSWKAFFINGHWQVYNKEDQ
(804) DNA topoisomerase 3 [Photobacterium profundum]
10
MTRLYIAEKPSLGRAIAAVLPRPHKNNNGYIETGNGDIVTWCIGHLLEQVEPDAYDEKYKKWNMADLPIIPEQWQLSPRKSVKQQLAVVRKLAKQATDIVHAGDPDREGQLLVDEVIDYVKVSAKKKTEIQRLLISDLNPAAVKRALSTMRSNREFIPLSVSALARSRADWLYGMNMTRAYTLLGQKGGYRGVLSVGRVQTPILGLVTRRDDDIANFKPKPFYEVFALIPYQDMDIRARWKPSEACQPWQDEEGRVLNRQLCENVLKRIKGQPAEVTESERKETRQAPPLPYSLSALQIDAAKRFGMSAVDVLANCQSLYEKHKVITYPRSDSRYLPNEHFKQANDVCRAVASNASELSNACNGANTTLKSKAWNDKKVDAHHAIIPTPKQISPNALSGSESKVYQLIARQYVMQFYPAAIYAEAKLVFTITQGHFIARGRQLMSAGWRELLGRDHAEDKTKVAGNSDQGLTDKVPPLDKGTILTCREGEIKDKVTEPPKAFTEATLLQAMTGIARFVSDSSLKKILRDTDGLGTEATRAGILELLFKRQLLMRQAKNIHATDAGRGLVYALPDEATYPDMTAHWEHQLQDMADKKCAYQPFMDALQQQVSQLMDKVKYSEVPESLRQLTSPESRKPMKKKRYTKSKKS
(801) DNA topoisomerase 1 [Photobacterium profundum]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTGARNAGKKAAAQSTAGLSVEEKARLKKIKDRKSLIGKMGVDPYNDWDAHYEVLPGKEKVVSELQKLAADADFIYLATDLDREGEAIAWHLREIIGGDDARYKRVVFNEITKNAIQQAFEEPGELNIDGVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLIVEREREIKAFTPEEFWDIHANTLTVGKDALRLIVSQQAGKAFRPVNEAQTMAAKSVLDSAEYKVVDREDRPTSSKPSAPYITSTLQQAASTRLGYGVKRTMGLAQRLYEAGYITYMRTDSTNLSNDAVVAAREFIGSEYGENYLPKEAIKYGSKKNAQEAHEAIRPSSVEVQAENLEGMDADAVKLYDLIWRQFVSCQMVPAKYDSSTITVQADEFTLKAKGRILRFAGWTLVQRPSGKNEDTTLPIVHVGDVMILEGVEPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVRVDQRRFYAEKMGEIVSDRLDGSFPDLMDFDFTARMEGNLDKIAEGEKNWKAVLDNFFSDFTTELERAELDEDEGGMKPNNIVVTDIECPTCSRPMGIRTASTGVFLGCSGYALPPKERCKKTINLGDEDGIVNVLEEDVETAALRAKKRCPKCDTAMDAYLIDQDRKLHVCGNNPSCDGYIVEKGEFKLKGYEGPLIECDKCGSDMELKTGRFGKYMGCTNEDCKNTRKILKNGEIAPPKEDPVHLPEIPCTQDSNAYFVLRDGASGLFMAASTFPKSRETRAPLVSELVRFKDRLSPKFYYLAEAPTEDPDGREAVVRFSRKSKENYVRTEVDGKPSGWTGLYVDGKWEITDKRKKPKKEKAEKED
(1744) DNA topoisomerase 1 [Thioalkalivibrio sulfidophilus HL-EbGr7]
1
MSKHLVIVESPAKAKTIKKYLGPDFEVMASYGHVRDLVPKEGAVDPDHGFRMNYQVIDRNERHVESIVKALRKADSLLLATDPDREGEAISWHLYELLRERGVLDAKTVQRVVFYEITQRAVKEAIEQPRGLSFDLINAQQARRALDYLVGFKLSPLLWKKIKRGLSAGRVQSPALRMIVEREEEIERFQTREYWTLEADLDKSGQAFNAKLHTLDGKKLDQFDIADEVTASAARNTLLSAADGRLRVARIEKKQRRRNPAPPFTTSTLQQEAVRKLGFSASRAMRVAQQLYEGIDLGAGPIGLITYMRTDSVTLAGEAIAEIRRLIEQRYGRNTLPEHPRQYKTKAKNAQEAHEAVRPTSVMRAPEEVKRHLTTDQFKLYDLIWKRTVACQMQHATLDTVSADLAAGSERHLFRASGSSVRDPGFMAVYQEGKDDAKEESDERILPPLEEGDIVKLEALRAEQHFTEPPPRYTEASLVKALEEYGIGRPSTYASIISTLQQREYVEMDSRRFIPTDIGRIVNAFLTQHFTQYVDYDFTARLEDELDEISRGEKEWVPVMEGFWSSFKEQIEEKEATVTRAEAVQSRELGIDPKSGRPVSVRMGRYGPVVQIGTKDDEEKPRFAGLPPGKKMDAVTLEEALELFKLPRELGETPEGEPVSVNIGRFGPYVKFGSRYASLKPEDDPFSIELPRALELVAEKKEADANKYIRVFDEAGVQVVNGRYGPYITDGNKNARIPKDRDPKSLTLEECQALLAAAPERKGRRGVKKAAPKKKAAAPKKAAPKKKAAPRKKATAKKKAAPKKAAAKKNATSGGESGAGLTR
(1828) DNA topoisomerase [Thioalkalivibrio sulfidophilus HL-EbGr7]
4
MRVFLCEKPSQGKDIARVLGARQRGNGCYSGSGITVTWCIGHLVEAAPPETYGEQYKQWSIEQLPILPERWRIEVKAKTAAQFKIVKQFVAQAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALTQLKPGGETLPLYFSALARSRADWLIGMNLSRLFTVLGRRSGYQGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWTIDVTLSHAGQSFAASWMPPDGTTDAAGRCLQQPVAQQAADRIRAGRESKVLSVETERVREAAPLPFDLGTLQEVCSRQLGLDVQETLDIAQSLYETHKATTYPRSDSGYLPESMLAEVPTVLDALLATDPGLRPLIDRLDRTQRSRVWNDSKITAHHGIIPTLEPANLSAMSEKELAVYALIRAHYLAQFLPHHEFDRTLVMLDCAGQSLQAVGKRVIVPGWHLALPGKGQDAADDEPAQRSQILPPLDTGARCGVQQVELKALKTLPPKPYTQGELIKAMKGVAKLVTDPRLKQKLKETTGIGTEATRAGIINGLLARGYLVKKGRAIRASDAAFTLIDAVPAAITDPGTTAIWEQALDMIEAGQMTLDTFINKQSAWVAQLVQQYRGTVLSIKLPEGPACPVCGAATRQRNGKNGAFWSCSRYPDCKGTLPAESSTGRRRASRQRRAAPKAS
(1802) DNA topoisomerase 1 [Dichelobacter nodosus VCS1703A]
1
MSYKHLLIVESPAKAKTLHKYLGNDYEVLASYGHVRDLIPKNGAVEPENDFAMNYELIERNAKHVAQIEKALKNADELLLATDPDREGEAISWHLFELLQEKGVLAEKTVKRVVFYEITQRAILQAVSAPRDIEMNLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSPALRMIVEREREIDAFQAQEFWNITAHCQQKEEPFLAELTLFAGEKLEQFSFTDEQKTQTAIETLKKQAQGQLTVIDIVSKERKRNPAAPFTTSTLQQEAARKLRSSAQKTMRVAQKLYEAGYISYMRTDSVHLAQEAIEACRLLIEQQYGAVYVPPTPPVYTTKSKNAQEAHEAIRPTDITLEAAMLSAEMGADERQLYDLIRKRTLASQMAAAVMEQTSVDLSAGDTQNIFHATGSIIKFAGFMSVYLEDREESAEENMNLLPKMDIGDVIVLTDIIGSQHFTAPPPRFSEASLIKALEEYGIGRPSTYASIISTLQNREYVESSNRRFVPTTIGKVVNDFLTNHFQRYVDYDFTADLEDELDAIARGEQEWKPLLKDFWAQFKAQIEKKSEISREEVMQARELGMDPKTGKTVTARFGRFGPFVQIGSKDDAEKPLFASIPEDWDFEKISLENALELFKLPRNLGKTEEDEEIVINNGRFGPYVRFGRKFVSLPKDEDPLTISKERALELIALKKEEDRKKHIKEIKNGDDILQVLNGRFGPYVTNGSINASIPKHIEPAALTLEDALALLEKAQERKVNRKKKATEKTSEKKAKTTKTAKKAAPKKSTAKTKSTKQAEKGINHD
(78) DNA topoisomerase 3 [Dickeya dadantii 3937]
10
MRLFIAEKPSLARAIADVLPKPHRRSDGFIACGEQDVVTWCVGHLLEQAQPDVYDARYARWSLADLPIVPQKWLLQPRPSVSKQLNVIKKLLNQADEIIHAGDPDREGQLLVDEVLEYLSLPEEKRQHVGRCLINDLNPQAVERAVSRLRENREFVPLCVSALARSRADWLYGINMTRAYTLLGRNAGYEGVLSVGRVQTPVLGLVVRRDEEIDNFVSRDYFEVKAHIVTPADERFIALWQPSESCEPYQDEEGRLLHRPLAEHVVKRIEGQPAWVTAYNDKRESETAPLPYSLSALQIEAAKRFGLSAQQVLDVCQRLYETHKLITYPRSDCRYLPEEHFAGRQAVLNAIAAHQPDLLPQPAVDPERRNRCWDDGKVDAHHAIIPTARSARTSLTESESQVYGLIARQYLMQFCADAMFRKCVIDLDIAGGKFVAKARFLAEAGWRTLLGNKERDEENEGMPLPVVEKGDELLCERGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKALKKILRETDGLGTEATRAGIIELLFKRAFLVKKGRYIHSTEAGKALIHALPPMAAHPDMTAHWEATLTQISEKRCRYQDFMQPLTQSLHELIQQARQSGNITAFRGLPPVKRAPPAGRKRRQSRSASTKE
(253) DNA topoisomerase 1 [Dickeya dadantii 3937]
9
MGKALVIVESPAKAKTINKYLGNDFVVKSSVGHVRDLPTSGSGSASKKSAEANGEKAKKAVKKDEKTALVNRMGVDPYRGWQANYEILPGKEKVVSELKTLAQNADHVYLATDLDREGEAIAWHLREIIGGDDKRFSRVVFNEITKNAIRQAFENPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWELHADLLANPDIALQMQVTHHNGKPFRPVNQAQTQAAVSLLEKASYVVAEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALAMARDYIQDEFGKRYLPEAPNLYTSKENSQEAHEAIRPSDVKVLADQLKDMEADAQKLYQLIWRQFVACQMMPAQYDSTTLVVSAGDYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPAIDVGQSLSLEKLLPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMENSLDLVANSQAEWKAVLDEFFAEFSKQLETAEQEPDEGGMKPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLIPEAEVLNVLEGDEAETNALRARRRCSKCGTAMDSYLIDNQRKLHVCGNNPSCDGYEIEQGEFRLKGYDGPVVECEKCSSEMHLKMGRFGKYMACTNESCGNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFRDRLPEKLRYLAEAPVTDPEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYVDGKWVESSR
(769) DNA topoisomerase 1 [Nitrosococcus watsonii C-113]
1
MSKNVVVVESPAKAKTIKKYLGKNFEVLASYGHVRDLMPKEGAVDPEHGFKMKYQAIEKNGRHVNAIAKALKSADSLLLATDPDREGEAISWHLLELLKEEGVLEDKAIQRVVFYEITSQAVNEAVAHPRDISLDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIDAFKVREYWTLEADAAAAKQPFVAKLTHLDGRKLTQFDIENKDQALALVERLTKAAAGELWVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSAKRTMSVAQQLYEGVDIGDGAMGLITYMRTDSVNLANEAVGEIRNFIAERFGQNSLPVKSRTFKTRAKNAQEAHEAVRPTSVYRVPEALKPYLKPEQFKLYQLIWRRTIACQMNHATIDAVAVDLDTQKAAPERGEDARGNIFRATGSTVVDPGFMAVYQEGRDDAKGEEEQRKLPPMKEGDRVALLQIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRDYTVLESKRFQPTDVGRVVNRFLTEHFNPYVDYDFTARLEDELDAISRGEKVWIPVLEEFWGPFSARIQEKEQNVSREEAVQARELGVDPQSSRPVSVRMGRYGPYIQIGSKEDEEKPRFAGLQPGQKMDAITLEEALALFKLPRELGFTPGGERVSVNIGRFGPYVKYDNKYVSLRGEDPHTIPLERALVLIEEKRQADANRVIKVFPDSGIQVLNGRYGPYVTDGERNVRVPKEQAPEELSLEQAQTLIHEAPVKRARRKAGSRKKAKG
(459) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(305) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFLPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEEIYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(348) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Gallinarum/pullorum str. RKS5078]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(192) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Gallinarum/pullorum str. RKS5078]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(985) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEERLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(867) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(771) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLSVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(226) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(205) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(386) DNA topoisomerase 1 [Xylella fastidiosa 9a5c]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPENGFAMRYDLIDKNEKHVEAITKAAKTADSIYLATDPDREGEAISWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRMIASDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFITREYWSIHAECAHPAQHFSAKLIKLDGQKFEQFTITDSDTAAAAQRRIQQVAQGRLHITDVTNKERKRRPAPPFITSTLQQEASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDIIARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVWKRAVASQMIPAILNTTSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPVMKTGENVPLERILTEQHFTQPPPRYTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVDMEGRSFRPTDIGRAVSKFLASHFTRYVDYDFTAHLEDELDAISRGEEEWIPLMKKFWVPFKELVEDKKDSLDKTDAGSVRLLGIDPTSGKEVSGRIGRFGPMVQIGTVDDEEKPRFASLRPNQSIYSISLEEAIELFKMPRVLGEDQSQQVSVGIGRFGPFAKRGSTYVSLKSEDDPYTIDLARATFLINEKEEIARNRIIKNFENSQIQVLNGRFGPYISDGKLNGKIPKDREPASLTLEEAQQLLIDTGKPARKNFSTKKTATKNETRKQTTKKRTTDAKATKKVSDKPVKKQIKKRIAPNITE
(1779) DNA topoisomerase [Xylella fastidiosa 9a5c]
4
MTRRSSAGRWSSCPLFRSSGGSRSNRRPPRNSKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTVLGLQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSVPFWAIDVSLSAGGQAFSAQWVPPDGCTDDAGRCLQQPIAQQAAQQIRAASSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRPIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETTARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIVQYGSTSLSIKVPQGPACPQCGAPTRQRTGKTGPFWSCSRYPDCKGTLPVDSGTSKRGASRPRSSGRKGS
(580) DNA topoisomerase 3 [Haemophilus influenzae R2846]
10
MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGDNDVVTWCVGHLLEQAEPDVYDPKFKQWRLEHLPIIPEKWQLLPRKEVKKQLSVVEKLIHQADTLVNAGDPDREGQLLVDEVFSYANLSAEKRDKILRCLISDLNPSAVEKAVKKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQTGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVQAWVNPESKEEKTPEKSTALFSALWQPSKACEDYQDDDGRVLSKGLAENVVKRITNQPAEVTEYKDVREKETAPLPYSLSALQIDAAKRFGMSAQAVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHNVLNAISTHCEAYQRLPNVISTEQRNRCWNDKKVEAHHAIIPTAKNRPIHLTQEERNIYSLIARQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQTAGWKELLGKEDDTENQEPLLPIVKKGQILHCERGEVMSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLTKKGRNIHSTETGRILIQALPDIATQPDMTAHWESQLTDISQKQATYQQFMHNLNQMLPDLVRFVDLNALRQLSRIKMIKSDRAKPKSAVKKSSKSNGQTD
(1866) DNA topoisomerase 1 [Haemophilus influenzae R2846]
9
MSKSLVIVESPAKAKTINKYLGSQYVVKSSVGHIRDLPTVGSSTGEKAKPISTKGMDAEEKAKIKAEKERNALVKRMGIDPYHDWKANYQILPGKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGNNDRFSRVVFNEITKNAIKQAFEKPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWEVAVLTNNQNKQAIRLDVTDYKGKKFDPKNQKEAQSAVDFLNVSDYVVTDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMARSYIENHFGAQYLPEKPNFYSSKENAQEAHEAIRPSDIRALPESLEGMEKDAVRLYDLIWRQFLACQMPPAQYDSSTLTVSAGDYTLKAKGRILRFDGWTKVLPQIGKNPEDQELPSVTVSEKLALKEVQPTQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNESFGELMNYDFTANMEDTLDKIASGSVNWKTELNQFFKDFSSQLSKAELDELEGGMRPNNLVETDIKCPTCDRNMAIRTASTGVFLGCTGYALPPKERCKTTINLIPEAELLNVLDESSETKALMDRKRCTKCGTAMDSYVIDAHRKIHICGNNPNCDGYLIEEGSFKIKGYDGPVVECDKCGADMHLKLGRFGKYMGCTNCDNTRKILKNGEVAPPKEEPVHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRPVKIAELVQYRERLPEKLAYLADAPQKDPEENEAIVRFSRKEKKQYVTSEKEGKATKWIVDFTNGKWVERKK
(213) DNA topoisomerase 3 [Haemophilus parainfluenzae T3T1]
10
MRLFIAEKPSLGRAIADVLPKPHQRGDGFIKCGNDDVVTWCVGHLLEQAEPDAYDPKFKQWRLEHLPIIPEKWILLPRKEVKKQLSVVEKLIHQADVLVNAGDPDREGQLLVDEVFSYANLSAEKRDGILRCLISDLNPSAVEKAVQKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQAGYDGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFYEVLAWVKEEKTSENPTALFSALWQPSKACEDYQDEDGRVLSLGLAENVVKRITDQPAEVTEYVDKREKETAPLPYSLSALQIDAAKRFGMSAQSVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHKVMNAISQHCQTYQTLPLVVDTEQRNRCWNDKKVEAHHAIIPTANTRSINLSIDEQRIYELIARQYLLQFCPDAEYRKSKIILSIAGGTFVAQARNLQTAGWKELLGKEDEDENQEPLLPIVKKGQILYCERGEVVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLTKKGRNIHSTETGRILISALPDIATQPDMTAHWEAQLTDISQKQASYQQFMFTLNQMLPDLVRFVDFTALRRLSQISKGLSTPATKRKRAVKKSEDLNAEN
(1632) DNA topoisomerase 1 [Haemophilus parainfluenzae T3T1]
9
MSKSLVIVESPAKAKTINKYLGSQYVVKSSVGHICDLPTAGSSTGEKAKPVSTKGLSAEEKNKIKAEKDRAALVKRMGIDPYHDWKANYQILPGKEKVVAELKSLAKKSDHVYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKKAIEKAFQHPAHINMDQVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEFWEIEALTQTSKKEDLRLDVVQYKGKKFEPKNEKEAQSAVDFLNKSHYVVTDLETKPTGSKPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMARSYIESHFGKDYLPAKPNFYSSKENAQEAHEAIRPSDVKMLADHLSGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVMAGDYELKAKGRILRFDGWTKVLPQLGKNPEDQILPAVSLNETLALKTVSPSQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRIENRRFYAEKMGEIVTDRLNQSFTDLMSYDFTANMENVLDQIASGEKNWKAELNQFFKDFSTQLSTAELDELEGGMKPNSLVLTDIDCPTCSRKMAIRTASTGVFLGCSGYALPPKERCKTTINLIPETELLNVLDEASETKALMDRKRCPICGTAMDSYIIDPHRKLHICGNNPNCDGYLVEQGQFKIKGYDGPIVECDKCGSDMHLKLGRFGKYMGCTNCDNTRKILKNGEVAPPKEEPVHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRPAKVAELALYRDRLPEKLRYLADAPQKDPEGNEAIIRFSRKEKHQYVTSEKNGKATKWIVDYIDGKWVERKK
(881) DNA topoisomerase [Haemophilus parainfluenzae T3T1]
4
MKLFLCEKPSQGNDIAKILGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFKKWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLAGFRGQIKRLWLSALDDASIRKALGALKDNEETLPLYYAGLARSRADWLIGMNFSRIYTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQYVIPEQYCDPDGLCLSAQVIQAANQQIRQLGQAKMESVETKRERQNAPLCFALSDLQSEANRLYGLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPKIIQCLLQSDNRLQPLAGMLNLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQFLPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQALPTLKQGQICQISDSEIKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQGLIDKGFLKKKGKSLLATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRHLMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFLGCSAYPNCQHIENFDSKKNTKGAKSSKKTSSKSVSEQISSLRSLLN
(481) DNA topoisomerase [Marinomonas posidonica IVIA-Po-181]
10
MILYIAEKPSLARAIAAALPGPQKKQEGCIWLPNGDCISWCIGHLLEQAEPHIYNPAFKTWQLDHLPIIPSDWQWQEKANTKKQLGILKKLIKQATQLVHAGDPDREGQLLVDEVLHYAKVPAQKLQQTQRVLISDLTPVAVKKSLQQLKSNAEFAALSRSALARARADWLFGLNLTRAYTIRGRQAGYQGVLSIGRVQTPVLGLVVARDTERENFVAKNYYQVWAQITTPENQHFQAKWLPSDACRPYMDEEGRVLNRALAKNVASRIENQPALVSQADYKQKKQPPPLPYNLSSLQIDAAKIFAMSAQQVLDTCQALYERHQIITYPRSDCRYLPTLQHRDAKAIINALSKGSEALAKSTKNANSNLKSKAWNDKQVTAHHAIIPTSQAHKAASLNKTESQIFGLIARQYLMQFYPDYQYLSTLIQLDIAGGKFEAKGSTPVALGWRSLLPTKKKSDHEEEQEQLPNLKKGDSLWCDQGIIRDKVTTPPAAFTDATLLAAMTGISRFVSDKSIKAILKETDGLGTDATRAGIIEILFKREFLIRQGKQIHASQTGRAFADTLPSQLVTPDMTAQWEAQLNAMSLGESRYQDFMAGLTDNLTDLLTQSKSVSTASLQHLPAPKRNPFKKRSATRKRSTKSKAKKPA
(1518) DNA topoisomerase 1 [Marinomonas posidonica IVIA-Po-181]
9
MGKSLVIVESPAKAKTINKYLGNDFVVKSSVGHIRDLPSGKTATSTPQERAKQAALTRKMSPEEKLEYKSRKSRKQLIARMGVDPEDNWHANYEVLPGKEKVVDELKRLAKNADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQSAFETPSELDLNRVNAQQARRFLDRVVGFMVSPLLWAKVARGLSAGRVQSVAVRLIVEREQEIRAFVPEEFWELDAMLSTSSDDMIKFEAAKYQGKEYRPVNQLQSDEHVARLQMAKYLVQSREDKPTKSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVESLRQYILSSFGEAYLPADPIRYSSKEGAQEAHEAIRPSDVNVRVDDLLGMEKDAHRLYDLIRSQFMACQMTPAEYTSTTITVVAEEYEFKAKGRILRFDGYTRAMQTVVKKGEDNILPDVTQGEFLDLKELLPEQHFTKPVARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGDIVTDRLVGSFSSLMDFSFTAQMEERLDEIAEGDKDWIQTLNAFYRDFSNVLAKAESPDDGMMLNEPTPTDVECPTCSRPMQIRTASTGVFMSCSGYALPPKERCKATINLIRGDEAVAVDDEEGESKALINKHRCKICGSAMDSYLMDEHRKLHVCGNNPSCTGYEVEAGSFKIKGYDGPVIECDKCSSEMQLKTGRFGKYFGCTNEECKNTRKLLKSGEVAPPKMDPVPMPDLACQKVEDHYVLRDGATGLFLAASQFPRKRETRAPYVKELIPYMDQIDPKYHFFADAPVADSEGRSTLIRYSRKTKEQYIMTENEGKPTGWKAFYDGGKWVIEEGKKKK
(716) DNA topoisomerase 3 [Actinobacillus succinogenes 130Z]
10
MRLFVAEKPSLARAIADVLPKPHSRGDGFIRCGENDYVTWCVGHLLEQAEPDAYNPSYKQWRLEHLPIVPQKWQLIPRKEVAKQLKIVEKLIHQADELVNAGDPDREGQLLVDEVFSYADLPADKKDKIQRCLVSDLNPNAVEKAVNKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQAGYNGVLSVGRVQTPVLGLIVRRDLEIENFRPKDFFEVLAQIKSEQNPTALSFTALWQPSKACEDYQDEDGRVLSRALAENVIKRITRQPAEVTAYEDKREKQTAPLPYSLSALQIDAAKRFALSAQDVLDTCQSLYEKHKLITYPRSDCRYLPNEHFADRHAVMNAISVHCTAYQTLPSAVNSEQKNRCWNDKKVEAHHAIIPTAKNRAVSLTAREQDIYGLIARQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQIAGWKELIGKEDDDEQLEAPLPVVKKGQMLFCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTEAGRILIQALPDLATQPDMTAQWEAQLNGISQKETSYQSFMFQLTQMLPELVQFVNFSALRRLSAVADRPKPTFKRKARKTADKSAVKSV
(639) DNA topoisomerase 1 [Actinobacillus succinogenes 130Z]
9
MSKSLVIVESPAKAKTINKYLGTNYVVKSSVGHIRDLPTAGASSGEKAKPISTKGLSVEEKSRIKAEKERNALVKRMGIDPYHDWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKNAIKQAFEKPEQLNIDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEFWEVAAELFTVHKAGIRLDVTAFKGKKFAPKNAEQAQSAVDFLAKSDFIVSDLETKPTSSRPRPPFITSTLQQAASTRLGFSVKKTMMLAQRLYEAGYITYMRTDSTNLSRDALGMVRGYIEQNFGDSYLPPKPNFYSSKENAQEAHEAIRPSDVNVSASHLSGMEKDAERLYDLIWRQFVACQMPAAQYDSTTLTVSAGDYELKAKGRILRFDGWTKVLPQMGKNPEDQELPAVALQEKLELGSVQPTQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFAELMNYDFTAGMEDMLDQIANGTKDWKAELNQFFKDFSGQLSQAELDELEGGMKPNSIVPTDIDCPACGRKMAIRTASTGVFLGCTGYALPPKERCKTTMNLIPESELLNVLDSETETKALMARKRCPKCGSAMDSYILDPHRKLHICGNNPNCDGYLVEEGAFKIKGYDGPVVACDKCGADMHLKLGRFGKYMACTNCDNTRRILKNGEVAQPKEEPIHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRESRPAEVAELALYRERLPGKLQYLADAPPKDPDGNDAVIRFSRKEKRQYVSSTDKNGKQTKWIVDFIDGKWIERSKK
(1604) DNA topoisomerase [Glaciecola sp. 4H-3-7+YE-5]
10
MILYIAEKPSLGRAIAQGFSGQQQKSDGYIKLANGDCVTWCIGHLLEQAEPDKYDPAYAKWALQHLPIVPQDWILVPKKGTSKQLSVIKRLLKTATKVINAGDPDREGQLLVDEVITYCKVKRDIIDNAGRLLINDLNLNAVKKSLTNIRPNREFTGLSISALARSRADWLYGLNLTRAYTLLGQRGGYSGVLSVGRVQTPVLGLVVRRDAEIAQFESKPFYDVIATLATQTSPSRQTFTAKWQPSAACEPYQDEEGRVIVKRLAETVVNKTRGQPGIVESYTVKDKQSPPPLPYNLSALQIDASKRYNLSPKAVLNVCQSLYERHQLITYPRSDSRYLPMEHFKDAQNVLSAIKANAPDQKSAVDNANSKLKSKAWNDSKVDAHHAIIPTSRRKALASLSGDEAKIYQLISTQYVMQFYGPHKYQEQVAVVTIAGGTFVAKAKATTDKGWLVLTKQSEAKQEPALPSLVKGQVLDCVDSQLVEKQTSPPKHFTEATLLAAMTGIARYVQDANIKKILKETDGLGTEATRASIIDLLFKRQFMQKSGKEIHATPTGKALVNALPSESTLPDMTAIWEANLDKISQRQMRYQDFMQPLTHTIGELINASQRIGTSQFAGLASTKPAYKKKWRKKKKAS
(829) DNA topoisomerase 1 [Glaciecola sp. 4H-3-7+YE-5]
9
MAKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGKVPPKKPAKELKLLSENKRESYLREHEYRKLVDRMGVDPKDDWAAHYEVLNGKEKVVNELKKLAKNADTIYLATDLDREGEAIAWHLQELIGDPSKDYQRVVFNEITKNAIQEAFSEPGKVNVERVNAQQARRFLDRIVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDVHANLLTAKDSDLRMQVAKYNDKAFKPTNKKQTDTALADLEGAEYKVISRDSKPTQSRPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSKEAVDACRDYIDDNFGAKYLPENALKYGSKEGAQEAHEAIRPSNVLLKSESLSEMERDAQRLYELIWRQFVACQMTPAKYDASTIRVSANGYELTAKGRVLKFDGWTKVQNPQRKKGEEDFLLPDVKEGESLSLKQLDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLESKRFYAEKMGEIVNDRLLENFDNLLSFDFTAKMEQELDEIANGKVSWKDVLNDFYGDFEKKLHLAEKDPDDGGMRLNQAVPTDIECPKCGRPMNVRTASTGVFLGCSGYNLPPKERCTGTMNLTSGDEVIKVDDEEELETELLRSKRRCPICSTAMDSYLVDETRKLHVCGNTPTCPGIEVEMGTFKIKGYDGPIIECDKCGSDMELKNGRFGKYFGCTNEECKNTRKLLRNGEAAPPKEDPVDLPELECTKSDAHFVLRDGASGIFMAAHNFPKSRETRAPLVAELARFRDRISPKFYYLADAPAKDPDGNDTLVRYSRKTKQQYVMSENEEGKATGWSAWYTDNKWTVEDKRKKAK
(721) DNA topoisomerase 3 [Glaciecola nitratireducens FR1064]
10
MIVYIAEKPSLGRAIATGFSGKQQKREGYIELDNGDCVTWCVGHLLEQAEPDKYDAAFAKWSLQHLPIVPDKWQLVPKKNTQKQLTVVKRLLKKATHIVNAGDPDREGQLLVDEVITYCGVKASIIENAGRLLINDLNTSAVKKALQNMRTNREFLGLSISALARSRADWLYGLNLTRAYTLLGQRGGYSGVLSVGRVQTPVLGLVVRRDQEIAHFVSKPFYEVIASLESQNKKTFNAKWQPSKACEPYQDEEGRVLSRKLAQTVVNKTRGQQAKVTDYKVQNRQSPPPLPFSLSVLQIEASKRFNLSPKMVLDVCQSLYEKHQLITYPRSDSRYLPKDQFGQASNVLGAIKSNVPNFASAVDNANPKLKSKAWNDSKVDAHHAIIPTNRSKAIGSFTQYEGKIYQLIANQYLMQFYGPHKYQEQVAKIDIAGGEFVAKGKSSQDLGWLALTKNQNNASDDNKNDTLLPQLNKGELLKCTDSQLMEKQTSPPKHFTEATLLAAMTGISRYVQDRNIKLILKETDGLGTEATRATIIDLLFKRQFMQKVGKEVHATETGKALINALPSETTYPDMTATWEADLDKIAQRQLRYDGFMQPLTESIARLIDNSQQLDSRQFAGLKSSKPTRKKRYFKKKSS
(763) DNA topoisomerase 1 [Glaciecola nitratireducens FR1064]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGLVEPKKPAKELSKWTDKKKAEYLKDYEYQKLVDRMGVDPKQNWMAHYQILQGKEKVVAELKKLAKDADTIYLATDLDREGEAIAWHLQELLGSKGKTYQRVVFNEITKNAIQEAFSDPGVVNINRVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDIHADLSTQKKDALKMLVAKHKGAAFKPINKKQADEAVSALENADYTVTSRESKPTQSRPSAPFITSTLQQAASTRLGYGVKKTMTMAQRLYEAGHITYMRTDSTNLSKDAVEGCRNYIQKNYGDKYFPSNPLTYGSKDGAQEAHEAIRPSNVAVKADSLKEMERDAQRLYELIWRQFVACQMTPAKYDATTIRVEANNYELTAKGRVLLFDGWTAVQPQIKRKGDNELLLPDVKQGDTLKLNELDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVKLDSKRFYAEKMGEIVNDRLVENFSDLISFDFTAKMEQRLDDIAHGETKWKSVLDNFYSEFSEQLENAEKSVEDGGMKLNQAVPVDIECSKCGREMNIRTASTGVFLGCSGYNLPPKEKCTNTMNLTPGDEVIKVDDEEELETEVLRAKRRCDKCGTAMDSYLVDENRKLHVCGNAPSCEGVFVEQGTFKIKGYDGPIIECDKCKSNMELKTGRFGKYFGCTNEECKNTRKLLRSGEAAPPKEDPVFLPELECEKSDAHFVLRDGAAGLFLAAHTFPKSRETRAPLVEELARFRDRISPKFYYLADAPKADPDKNPTIVRFSRKTKQQYVMSEDGKGKATGWSAWYENGKWVADDKRKKAKKEPKK
(1133) DNA topoisomerase 1 [Shewanella frigidimarina NCIMB 400]
9
MESIFFFSRLFGANKTMGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSTSDGTTVTKTAAEVKKLSPEEKAKYKLIRDKQALVARMGVNPDKGWAAKYQILPGKEKVVKELKALAETADQIYLATDLDREGEAIAWHLQEIIGGDPSRYQRVVFNEITKTAIQDAFSKPSVLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDIHAELNTPTAASLKMQVMKYQSAAFEPINEAQAKVAVDALRDATYVVTAREDKATSSKPSAPYITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSKEAVENLREMIAAEFGDKYLPAEPIRYGSKEGAQEAHEAIRPSNVAVQSASLTDMERDAQRLYELIWRQFVSCQMTPAQYDATRLTVTAGDYELKASGRTLRFDGWTRVQPQVSKKNEEDKTLPVVAKGDKLVLETLSPKQHFTKPAPRYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVDNRRFFAEKMGEIVSERLVGSFKELMSYDFTASMEQTLDDVAQGKLDWKKVLDGFYGDFTKQLLLAELDPDEGGMRPNEMVLTDDIKCPTCCRPMGIRTGSTGVFLGCSGYALPPKERCKTTLNLTPGEEAVSDNEDGETEALRAKHRCGKCGTAMDSYLIDETRKLHVCGNNPSCDGYEVEAGQFKIKGYEGPIIECDRCGNNMELKNGRFGKYFGCTNSECKNTRKLLRSGEAAPPKEDPIFLPELKCTKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVQYRDLLWPKYAYLADAPVEDDEGNKASVKFSRKTKEQYVATEVDGKATGWSSKFIGGKWVSESTKKKAKK
(1363) DNA topoisomerase 3 [Shewanella frigidimarina NCIMB 400]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFITAANGDCVSWCIGHLLEQAEPDAYDDAFKSWKLEHLPIVPQTWKLQPKPKTRSQLTVLRKLVKHASSIINAGDPDREGQLLVDEVISYLGVKGDKLNQVQRLLISDLNPQAVKRALGQLRKNREFVPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPLLGLVVRRDDEIADFTPKAFYEVLAHLLTDQQQAFTAKWQPSEACQPYMDEDGRVLAKGLAENVVARINDKPAEVTKIEAKDKRQNPPLPYSLSALQIDAAKRFGLSAKEVLDTCQSLYERHKLITYPRSDSRYLPKEQHALAPKVLDAVLKGASGLIEGCESPNSKLKSKAWDDSKVDAHHAIVPTEKVANLSTLSSNEAKLYQHVARQYLAQFYPAYIYAETAVEVTIAGGLFTTKARQDKTLGWKQLFKRTATVNQASSNSTSSDDDNDDAVLSLPPLVKGQILHCQRGELLQKMTQAPKHFTDATLLGAMTGISRYVTNSEIKKILKETDGLGTEATRAGIIELLFKRGYLVRQGKSILATPVGVGLIRSLPESATTPDMTALWENSLDAISQKRLKYDAFMQPLLSQLDGLITQASSQLPSALQGVASSAPKRSFKKSYKKKAKAKS
(71) DNA topoisomerase 1 [Alcanivorax borkumensis SK2]
9
MGKSLVIVESPAKAKTINRYLGDDFIVKSSVGHVRDLPVSGGSKKSTPQERAKEAAYTRSLPKEERDAYKKKKAKKQLINRMGIDPENGWAAHYEVLPGKDKVVDELKRLAAKADRIYLATDLDREGEAIAWHLREVIGGDEERFDRVVFNEITKKAIQAAFEEPGKLDLHRVEAQQARRFLDRVVGFMISPLLWEKIARGLSAGRVQSVAVELVVEREREIRAFIPEEFWELYSDTHSGDGEALRLQVAKHNGLAFRPNNGDDAAAHKQALENAGRLTISQREQRPTRSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSSDAVAACREWIGEKLGDKYLPDEPLSYSSKEGAQEAHEAIRPSDVRRTSDSLKDMERDAQRLYELIRRQFIACQMPPAEYLSSTLTAIGNGYELKAKGRIMKFDGWTRIQPPASRKGQEDTLLPDVKEGDVLAIDNVDANQHFTKPPARFTEASLVKELEKRGIGRPSTYAAIISTIQDRGYVRQDNRRFYAEKMGDIVTDRLVESFPNLMDYGFTASMEETLDEVAEGRRNWQDVLNEFYKDFVSKLDAAQGEGTGKQAVGGMRANLPTDTDIECPSCGRPMQIRTGSTGVFLGCSGYALPPKERCTATLNLLPGEEAEAVKTDDDEEAETNELRSKKRCQKCGTAMENYLIDEKRKLHICGNNPDCDGYVIEKGEFRIKGYDGPVLECEKCGNDMQLRTGRFGKFFKCTNDECGNTRKLLKSGEPAPPRADPIPMPHLQCQKVDDHYLLRDGASGLFLAASKFPKNRETRPPLIEEIQSVAEQLDPKHAYLAQAPATDPDGNKGVLRYSRKAKEQYVMSEIDGKATGWMAFYRDGKWVEEQAKKKAPAKKKAAAKKKATKKKAAAKK
(1519) DNA topoisomerase 1 [Kangiella koreensis DSM 16069]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSIGHIRDLPTGSQNKKPVDAKERARKAAATRKLSPEQKAKQKALKEKTALFARMGINPEHDWEARYEVLPGKEKVLNELKKFAKDADTIYLATDLDREGEAIAWHLRELLDGKETQFKRVVFNEITKKAIQQAFAKPGDLDMNYVNAQQARRFLDRVVGFMVSPLLWRKISRGLSAGRVQSVAVRLLVEREREIRAFIPEEYWDIHANTLTQSKDDLRLQVNKYQGKNFRPNSEQETNKALEVLKSSSYKVVTREDKPQKSKAPKPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTYLSTDAVDACRDYIKTNIGAEYLPKEANSYSSKEGAQEAHEAIRPSDVTKKVGHLSGMEKDAERLYDLIWRQFVACQMLPAEFDVTSLKVQAGDYELKARGRVMRFDGWTQVLPMQKKNAEDEELPNVKEGELLELKKLDPKQHFTKPPARFSEAALVKELEKRGIGRPSTYASIISTIQDRGYVRIENRRFYAQKIGEIVTDRLVESFSDLLDFSFTATMEKHLDDIASGRQNWKVTLDEFYDEFSQQLKKADEEEGEGGMRRNEAVETDILCDKCKKNHMAIRNASTGVFLGCMGYSLPPKERCKNTVNLIPGEEFIAADEEEEARYLHDKKRCTKCNSTMDDYLVDENTKLYICGNNPDCDGYEIEKGEFKIKGYDGPILECDKCGSEMQLKTGRFGKYFDCTNDDCKNTRKLLKSGQPAPPKADPIPMPELQCEKVDDHYVLRDGAAGIFLAASKFPRNRETRAPAVDELVTVKDKLDPKYKFLGEAPLKDPDGNRTFVKFSRKTGQQYVAGVKEDGKASGWTAFYENGKWVPQK
(33) DNA topoisomerase 1 [Hahella chejuensis KCTC 2396]
9
MTAISTRSKEPSAMGKSLVIVESPAKAKTINKYLGSEYVVKSSVGHIRDLPTSGGKETSSPKERAAEAAKMRKLPAEERESIKKRKARDQLISRMGVDPENDWAARYEVLPGKEKVVEELRRLAKSADQIYLATDLDREGEAIAWHLKESIGGDDSRYRRVVFNEITKSAITEAFKSPGQLDYNRVNAQQARRFLDRVVGYMVSPLLWSKIARGLSAGRVQSVAVRLIVEREREIRAFTPEEYWELHALLSKSKQQAKFQVAKYKGENYRPTNKAQSDKLTALLQTQAFKVVNREDKPSVTKAPAPFITSTLQQAASTRLGFSVKKTMVLAQRLYEAGYITYMRTDSTNLSADAVNACREFIGKKFGDKYLPDNPKTYVSKERAQEAHEAIRPSDINVGANQISGLEKDAEKLYDLIWRQFVACQMENARFLSTSIQVQAGDFELRTRGRLLQFDGFLKVLPAQAKKDDEAELPAFEVNDQLDLDKLEPTQHFTKPAPRYTEATLVKELEKRSIGRPSTYASIISTIQERGYVKLANRRFYAEKMGDIVTDRLTEAFTDLMDYGFTAKMEGQLDEIASGNEGWKQVLNAFYSDFAKKLEKADMEGGMRANQAVQTEIACPTCSRPMQIRTASTGVFLGCSGYALPPKERCKTTINLIPGDEVIRADDEEGEANALRAKKRCPICDTAMDSYVIDETRKLHVCGNNPDCEGYEVEGGQFKVAGYDGPTLECDKCGAEMQLKTGRFGKYFGCTSSTCGNTRKLLKNGEPAPPKMEPVVMPELACDKVDDIFVLRDGASGLFLAASKFPKNRETRAPLVEELIPHKKEIDPKHHYLLEAPTRDPEGNPAIIRFSRKTKQQYVMSEKGGKPTGWSAFYKDGKWVAKDK
(1721) DNA topoisomerase 3 [Shewanella woodyi ATCC 51908]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGHIIAGNGDCVSWCIGHLLEQAEPDAYDPEFKSWKFEHLPIVPDSWKMKAKPKTRSQLTILKGLIKQASQLVNAGDPDREGQLLVDEVIAHFGVKGDKLHQTKRLLISDLNPQAVKRALGQMRSNREFIPLSTSALARSRADWLYGLNMTRAYTIQGRKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFVSKPFFEVLANLSTEHNEHFKAKWQPSEACQAYMDEEGRVLSKGLAQNVVGRITEQPACVVGLDSKDKKQNQPLPYNLSSLQIDAAKRFGMSAKEVLDTCQALYEKYKLITYPRSDSRYLPIEQFSMAPSVIKAVLSGASELVIGPEQPDSKIKSKAWNDKKVDAHHAIIPTEKTANLAGLTPRERQIYLQLARQYLAQFYSPYQYHETLVEVEIAGGKFKTKAKQDKSLGWKQLFAKKGEKLEEKGSAVGDSSDDDLDALQKLPQLKKGQALHSGQGELIEKQTQAPKHFTDATLLGAMTGINRYVTDPEIRKILKDTDGLGTEATRAGIIELLFKRNYLSRSGKSIVATDVGKGLINSLPMSATTPDMTALWESNLDAISRKEAKYINFMSPLVDSLAQLITQAGAQLPTSLQGIKAPKSNFKKRAYSRKKTTKSAAKPSGRRATKVS
(342) DNA topoisomerase 1 [Shewanella woodyi ATCC 51908]
9
MEPIYKFLRLFGADHSMGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSTAEANVATKTPAEVRKMSPEEKAIYKSKRAKQALVTRMGVDPENGWKAKYQTLPGKEKVVKELQALAASADHIFLATDLDREGEAIAWHLQEVIGGDASRYQRVVFNEITKSAIQDAFSKPATLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEKEGEIKAFVPEEFWDIHANLTTLANDALKMEVVKFQEKAFNPVNELQAQTAVSALSQSSFVVAAREDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVDNVREMIGKEYGDKYLPDAPIRYGSKEGAQEAHEAIRPSDVSVHAAGMKDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGEYELKATGRTLRFDGWTRVQTAVKKKNEEDNTLPVVAKGDVLSLEELLPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLIGSFKELMSYDFTASMEQTLDDVAQGELEWKKVLDGFYQDLTKQLDQAELAPEEGGMRPNEMVLTDIKCPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTAGEEAVSENSEDAETDALRAKHRCGVCGTAMDSYLIDETRKLHVCGNNPICGGYEVELGQFKIKGYEGPIIECDRCSNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFMAASTFPKSRETRPPLVEELVKYRELLWPKYAYLADAPVEDDDGNKSTVRFSRKTKEQYVATEVDGKATGWTSKFVDGKWVTESKKKAKPKAKPKAKAKAKS
(907) DNA topoisomerase 3 [Shewanella amazonensis SB2B]
10
MRPPGIFATFTVNSSSAFAPEYPAMILYIAEKPSLGRAIAEVLPKPHKKGEGYIELGNGDCVTWCIGHLLEQAEPDAYSPEYKQWQLAHLPIIPAEWKLTPRSSAKSQLAVVKRLIKQASSLVHAGDPDREGQLLVDEVISHAKVSASKLASTQRLLISDLNPDAVRRALGQLRSNKEFVPLATSALARSRADWLYGLNMTRAYTLQGRKVGYAGVLSVGRVQTPLLGLVVRRDLDIEHFEPKDHYEVLAHITTDKGESFCAKWQPSEACQPYMDEEGRVLSRRLAETVVSRIGGKPALVEHVSHKDKKQAPPLLYSLSALQIDCAKRFGMSAKEVLDTAQSLYERHKLITYPRSDSRHLPKEQLALVPDVLSAVSANAPELLEGAPSPDLHLVSKAWDDSKVDAHHAIVPTGKRTALSQLNQRERQLYLHIARQYLAQFYPNRLLADTEIQLIIEGGSFIARASVERAPGWRVLFQGRSTEQDEAKEPQETDASQKTPLPALNKGDIARCCHGELLAKQTQPPKHFTDATLLSAMTGIARYVSSPDIKRILKDTDGLGTEATRAGIIELLFKRGFLVRQGKSIVASQAGRGLIASLPEVATTADMTALWERQLSDICQRQLSYKGFMTPLVLELEKLIEQAAASLPTALAGVTAAGPKRSFRGRAGKGKGRAPGASAGRGRKSRSSPSGKVAT
(1421) DNA topoisomerase 1 [Shewanella amazonensis SB2B]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSAAEGKASTKSAAEVRKMNPEEKAKYKAQKDKQALVARMGVDPEHGWQANYQVLPGKEKVVKELQSLASSADQIYLATDLDREGEAIAWHLQEVIGGDESRYKRVVFNEITKGAIQEAFSRPTDLNTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREAEIKAFVPEEFWDVHATLSTPAAAELVMEVSRYRNEAFEPVTQSEAMAAVNALEKAAFTVTDREDKATSSKPSAPFITSTLQQAASTRLGFGVKKTMMLAQRLYEAGHITYMRTDSTNLSQEALENVRAHIEKEFGSKYLPESPIRYGSKEGAQEAHEAIRPSNVKVESATLIDMERDAQRLYELIWRQFVACQMTPAVYDATRITAKAGDYELKASGRILKFDGWTRVQPALKKKNEEDNTLPDVQVGDMLSLKALDPKQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVKVENRRFYAEKMGEIVTERLVESFSELMNYDFTAGMEQTLDDVAKGDKDWKGVLDGFYSGFTAKLEKAEAEPDAGGMRPNQMVLTDIPCPTCGRQMGIRTGTTGVFLGCSGYALPPKERCKTTLNLTPGEEAISDSSEDAETDALRAMHRCGKCGMAMDSYLLDETRKLHVCGNNPECDGYEVEKGAFKLKGYEGPIIECDRCGSDMELKNGRFGKYFGCTNESCKNTRKLLKNGEAAPPKEDPIHLPELKCTKSDAYFVLRDGAAGIFLAASTFPRSRETRAPLVEELKKYREALWPKYQYLADAPVEDAEGNKALVKFSRKTKEQYVATEVNGKATGWSAHFKDGKWVESK
(713) DNA topoisomerase 3 [Shewanella oneidensis MR-1]
10
MILYIAEKPSLGRAIADVLPKPHKKGEGFIEDANGNCVSWCVGHLLEQAEPDAYNPDFKSWKFEHLPIVPEKWQLKPKAATRSQLTVLKKLIKQADTLVNAGDPDREGQLLVDEVIAYLGVTGDKLQQTQRLLISDLNPQAVKRALSQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLIVRRDEEIAHFQSKPFYEVLAHLVTDKQQFFSAKWQPSEACQPYMDDEGRVLSKGLAQNVVRRITDKPAKVTQLSTKDKQQSAPLPYSLSALQIDAAKRFGMSAKEVLDTCQSLYERHKLITYPRSDSRYLPTEQHGLASSVLNAITSGAPELVAHSEAPNPRLKSKAWDDKKVDAHHAIIPTEKQPNLGSLSQRERQLYLHIARQYLAQFYPAYCYSETAVEVTIEGGLFKTKARQDKSLGWKQLFAREEGERKDTSNTETFAQDDKDKDEGEYAGQLPPLILGQVLHCNQGELVEKQTQPPKAFTDATLLGAMTGINRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFIQRQGKSIVATEVGKGLINSLPLSATTPDMTALWEASLNGICHKDISYQGFMQPLLGTLHSLIQNAGAQLPSALNGLKGQGFKRAATKKSGYRKAGVRGAAGGKKAGTGAKNARNSAAASSTSTTAKPTVPRRRTSKATAQA
(1060) DNA topoisomerase 1 [Shewanella oneidensis MR-1]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSISDGTEKVKSAAEVKKMSPEEKARYKKVKDHQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQEAFSKPASLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAQLNTPSSEALRMEVVKYLDSAFEPTNEQQALAAVQALSSASFKVIAREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDSVREMIGKEYGAKYLPAEPIRYGSKEGAQEAHEAIRPSNVKVEAAALTDMERDAQRLYELIWRQFVSCQMTPALYDATKLTVKAADYELKATGRILRFDGWTRVQTAIKKKNEEDNTLPAVNEGDVLSLVELEPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQERGYVKVENRRFYAEKMGEIVSERLVNSFAELMSYDFTASMEQTLDDVAKGELDWKKVLDGFYADFTKQLEKAELAPEEGGMRLNQMVMTNIKCPTCGRPMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGIEAISDSEDAETDALRAKHRCGICGTAMDSYLLDEKRKLHVCGNNPVCEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNEECKNTRKLLKNGEAAPPKEDPIYLPELKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYREFLWPKYQYLADAPIADDDGNKAVVKFSRKTKDQYVATEVDGKATGWSAHYVNGKWVSESSAKKAKK
(1252) DNA topoisomerase 1 [Nitrosococcus halophilus Nc 4]
1
MSKNLVVVESPAKAKTIKKYLGKDFEVMASYGHVRDLMPKEGAVDPEHGFAMKYQVIEKNSRHVDAIAKALKKADALLLATDPDREGEAISWHLLELLKERGALEGKSIKRVVFYEITQQAVNEAIAHPRDISSDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIEAFKIQEYWTLEADAAASKHPFVAKLTHLDGHKLGQFDIDNGDRAQALVEQLTKAASGELLVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSTKRTMSVAQQLYEGVDIGDGAVGLITYMRTDSVNLANEAVKELRDFIAGHFGEKSLPAKPKTFKTRAKNAQEAHEAIRPTSVYRTPEELKPHLKPEQFKLYQLIWRRTIACQMNHATIETVAVDLDTRKSVPEKGVSNTGSNIFRATGSTVVDPGFMAVYQEGRDDTKAEEEQRILPPMKEGDRVELVRIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRSYALLENKRFHPTDVGRVVNRFLTEHFNPYVDYDFTARLEDQLDAISRGEKVWIPVLEEFWEPFLGRIQEKEQSVSREEAVQARELGIDPKSGRPVSVRIGRYGPYVQIGSKEDEEKPRFAGLRPGQKMDTITLEEGLALFELPRELGFSPEGEKVSVNIGRFGPYVKYDNKYVSLRGEDPYTIALERALELIQEKKQADANRVIKVFPDSGIQILNGRYGPYVTDGERNARVPKDQAPEKLSLEQAQTLINEAPAKRARRKTGTRKKAKG
(587) DNA topoisomerase 1 [Brucella microti CCM 4915]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1296) DNA topoisomerase 3 [Shewanella sp. W3-18-1]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFIEAANGDCVSWCVGHLLEQAEPDAYNPEFKAWKFEHLPIVPDKWQLTPKAATRSQLTVLKRLVKQASMLVNAGDPDREGQLLVDEVIAYLGVTGDKLHQTQRLLISDLNPQAVKRALTQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDKEIANFQSKPFYEVLAHLATDKQETFSAKWQPSEACQPYMDEEGRVLARGLAQNVVSRISDKPALVTQLVAKDKKQHPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPVEQHNLAPSVLKAISDGAAELLQGADAPDPRLKSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHIARQYLAQFYPAYCYSETTVQVTIEGGLFNTKARQDKSLGWKQLFARQEPNGSKASGNKSTEESAGKDDEEHDEFIGQLPPLKLGQALHCTRGELLEKNTQPPKAFTDATLLSAMTGISRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVSTDVGKGLINSLPLSATTPDMTALWEASLNGICHKETSYQGFMQPLLGTLSTLIQNAGAQLPTALNGLKGQGYRKTASHKSGYRKSYSKKSSSAKGIGTTKNDVSNKYGSQKTSSKSSVTRSTSRSASNSRKSTAAV
(1556) DNA topoisomerase 1 [Shewanella sp. W3-18-1]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSEGNEKVKSAAEVKKMSPEEKAQYKKVKDQQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAQLTTPAEESLRMEVVKHLDSAFEPINEQQALAAVQALSSASFKVISREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALESVRDMIGKAFGAKYLPAEPIRYGSKEGAQEAHEAIRPSNVHVEATDLTDMERDAQRLYELIWRQFVSCQMTPAQYDATKLTVKAGDYELKATGRTLRFDGWTRVQTVLKKKNEEDNTLPFVSQGDVLALKELQPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSERLVSSFADLMSYDFTASMEQTLDDVARGELDWKKVLDGFYADFTKQLEKAERDPEEGGMRLNQMVMTDIKCPTCGRPMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGVEAISENSEDAETDALRAKHRCGICGTAMDSYLIDEKRKLHVCGNNPICEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNEECKNTRKLLKNGEAAPPKEDPIYLPELKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPICDDEGNKAAVKFSRKTKEQYVATEVDGKATGWSAHYINGKWVSESTAKKSKKA
(823) DNA topoisomerase 3 [Shewanella loihica PV-4]
10
MILYIAEKPSLGRAIADVLPKPHKKGEGYITAANGDTVSWCIGHLLEQAEPDSYDPAFKSWSFDHLPIVPQQWKMTPKSKTRGQLSVLRKLVKQASQLVNAGDPDREGQLLVDEVIAYLGVKGDKLEQTQRLLVSDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTLQGRKVGYQGVLSVGRVQTPLLGLVVRRDEAIEHFVSKPFYEVLANLYTQEQAHFKAKWQPSEACQPYMDEEGRVLSRRLAENVVGRITEQPAKVTDLQAKDKQQGQPLPYNLSSLQIDAAKRFGMSAKTVLDTCQSLYEKHKLITYPRSDSRYLPKEQLALAPSVIGAVLKGAGELTAQCAAPDLKIVSKAWNDAKVDAHHAIVPTEKVANLSALTQAEKQIYLQLARQYLAQFYPVYRYHETQVEVEIAGGHFHTKAKQEIALGWKQLFPKRSDDKTDGEGDEALAQLPPLHKGQMLHSGQGELIEKQTQPPKAFTDATLLSAMTGISRYVTNPEIRKILKETDGLGTEATRAGIIELLFKRGFLARQGKSIVSTPVGRGLINSLPESATTPDMTALWESHLDAISRKEAKYLSFMAPLVESLNGLIMQAGAQLPKALQGVEAPKRSFKKRGYGNRRGTATGAKGKASGAKKTAARAASKTRAKTSA
(325) DNA topoisomerase 1 [Shewanella loihica PV-4]
9
MEPIYRILRLFGADHSMGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSSSDASSSTKSPAEVRKMSTEEKAKYKADKAKKALVARMGVDPERGWKAKYQTLPGKEKVVKELQSLAENADHIFLATDLDREGEAIAWHLQEVIGGDPERYQRVVFNEITKSAIQEAFSHPSQLNTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEREGEIKAFVPEEFWDIHAELTTLGNEGLKMQVAKFKGDNFNPVNEAQAMVAVNALKDSKYQVSSREVKATSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDSVRDMIGKEYGDKYLPDAPIRYGSKEGAQEAHEAIRPSDVNVSATSLSDMERDAQRLYELIWRQFVACQMTPAKYDATRLTVTAGDYELKASGRTLKFDGWTRVQTALKKKNEEDNTLPMVAEGDVLALEELLPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLIGSFEELMSYDFTAGMEQTLDNVAQGQLEWKKVLDNFYKGLTAQLEKAELPPEEGGMRPNEMVLTDIACPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSENSEDAETDALRAKHRCDVCGTAMDSYLIDEKRKLHVCGNNPICGGYEVEQGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNSECKNTRKLLKNGEVAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPVADEDGNKAVVRFSRKTKEQYVATEIDGKATGWTAKFVGGKWVSEAKAKPKAKKKA
(522) DNA topoisomerase 3 [Shewanella piezotolerans WP3]
10
MILYIAEKPSLGRAIADVLPKPLKKGEGFIRAANGDCVSWCVGHLLEQAEPDAYSPEYKSWKFEHLPIVPDVWKMKPKYKMRGQISVLRGLVKEATQLVNAGDPDREGQLLVDEIIAHLGVKGNKLTQAKRLLISDLNPQAVKRALGQLRLNREFIPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPILGLVVRRDEEIAHFVSKPFFEVIAHLTAEPQQTFTAKWQPSEACQPYMDEDGRVLSKGLAQNVVGRITGQPATVEKVNAQDKKQNAPLPYNLSSLQIDAAKRFGMSAKTVLDTCQSLYERHKLITYPRSDSRYLPQEQHGMAPSVINTVNKGAPELTQGIDAPNAKLKSKAWNDKKVDAHHAIIPTEKVANLSSLSPAEKQVYLLVARQYLMQFYSAYQYKETQVEIIIAGGLFKTKAKQEIAKGWKLLLKQSKASTSSDSNGQDEDELATIPPLTIGQKLFCDRGQLLEKQTQPPKHFTDATLLSAMTGISRFVTDVEIRKILKDTDGLGTEATRAGIIELLFKRSFLVRQGKTIVATDVGKGLINSLPLSATTPDMTALWENNLDSMSRKETQYQAFMQPLISKLDELITQAGSVLPTALQGVKSPTPFKKKSYARKGGKGQSTTKKNVGKPRMAKS
(854) DNA topoisomerase 1 [Shewanella piezotolerans WP3]
9
MEPIFRFLKLVGANKYMGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSSPDAKVVSKTPAEVKKMSPEEKAEYKSLKAKQALVARMGVDPEKGWKAKYQTLPGKEKVVKELQTLAESADHIYLATDLDREGEAIAWHLQQVIGGDESRYQRVVFNEITKSAIQDAFSQPSVLDTNMVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVRLVVEREGEIKAFVPEEFWDVHAELNTLCDERLKMQVAKFQGKAFNPVNQTEADAAVSALSQSSFVVAGREDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVREMIGKEYGDKYLPEAPIRYGSKEGAQEAHEAIRPSNVKVTAASLSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVAAGDYELKASGRTLRFDGWTRVQTAIKKKNEEDNTLPVVAKGDTVTLQELMPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVDNRRFYAEKMGEIVSDRLVGSFQDLMSYDFTASMEQTLDDVAQGKLDWKKVLNGFYKDFTKQLENAELPPEEGGMRPNEMVITDIKCPTCGRPMGIRTGSTGVFLGCSGYALPPKERCKTTLNLTPGEEAVSESGEDAETEALRAKHRCGICGTAMDSYLIDETRKLHICGNNPTCEGFEVEAGQFKIKGYEGPIIECDRCQNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPDLKCTKSDAYFVLRDGAAGIFLAASTFPKSRETRGPLVEELVKYRELLWPKYAYLADAPVADDDGNLASVRFSRKTKEQYVATDVDGKATGWTAKFIDGKWVAEAKAKAKPKAKAKPKAKPKAKAKPKAE
(629) DNA topoisomerase 3 [Shewanella baltica OS155]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFIEAANGDCVSWCVGHLLEQAEPDAYNPEFKSWKFEHLPIVPDKWQLKPKAATRSQLTVLKRLVKQANTLVNAGDPDREGQLLVDEVIAYLGVTGDKLHQTQRLLISDLNPQAVKRALTQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFQSKPFYEVLAHLATEKQETFSAKWQPSEACQPYMDEEGRVLARGLAQNVVSRISDKPALVTQLVAKDKKQNPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPVEQHSLAPSVLKAISGGAAELLQGADAPDPRLKSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHVARQYLAQFYPAYCYSETTVQVTIEGGLFNTKARQDKSLGWKQLFARQEPNGSKASGNKSTEENAGKDDEENDEFIGQLPPLKLGLALHCTRGELLEKNTQPPKAFTDATLLGAMTGISRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVSTDVGKGLINSLPASATTPDMTALWEASLNGICHKETSYQAFMQPLLGTLSTLIQNAGAQLPTALNGLKGQGYRKTAGNKSGYRKSPYRKASSSAKRTGTASTAKTSTTTSSSAKKSSASSGTRSRTRKVAAEV
(1232) DNA topoisomerase 1 [Shewanella baltica OS155]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSEGNEKVKSAAEVKKMSPEEKAQYKKVKDQQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAELSTPAQEALRMEVVKHLDAAFNPINEQQAMAAVQALSAASFTVLAREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVENLRDMIAKEFGDKYLPAEPIRYGSKEGAQEAHEAIRPSNVHVQAATLSDMERDAQRLYELIWRQFVSCQMTPAQYDATKLTVKAGDYELKATGRTLRFDGWTRVQTALKKKNEEDNTLPFVAQGDVLALKELQPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSERLVGSFADLMSYDFTASMEQTLDDVARGELDWKKVLDGFYADFTKQLEKAELDPEEGGMRLNQMVMTDIKCPTCGRSMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGVEAISENSEDAETDALRAKHRCSICGTAMDSYLIDEKRKLHVCGNNPICEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNSECKNTRKLLKNGEAAPPKEDPIYLPDLKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVQYRELLWPKYQYLADAPVTDDEGNKAAVKFSRKTKEQYVATEVDGKATGWSAHYVNGKWVSETTKKAKKSA
(987) DNA topoisomerase 3 [Shewanella pealeana ATCC 700345]
10
MILYIAEKPSLGRAIADVLPKPLKKGDGFIRAANGDCVSWCVGHLLEQAEPDAYSPEYKSWKFEHLPIVPETWKMKPKYKMRGQIAVLRGLVKEASQLVNAGDPDREGQLLVDEIIAHLGVKGPKLQNAQRLLISDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPVLGLVVRRDAEIAEFISKPFYEVLAHLATDNQQRFSAKWQPSEACQPYMDEEGRVLSKGLAQNVVGRINGQNGTVEKVTAQDKKQNAPLPYSLSALQIDAAKRFGMSAKSVLDTCQSLYEKHKLITYPRSDSRYLPAEQHALAPSVIGAVLNGASELVSGIEQPNSKLKSKAWNDKKVEAHHAIVPTEKTANLQNLNQAEKQLYLQVARQYLMQFYPAYLYKETQVEIIIAGGLFKTKAKQEVALGWKQLLKQNKEKSQSEKQQTDDDEYLANIPALKKGQILLCERGELLEKQTQPPKHFSDATLLGAMTGISRYVTDSEIRKILKETDGLGTEATRAGIIELLFKRNYLTRQGKSILATEVGKGLINSLPLSATTPDMTALWENNLDAISRKEAKYQSFMAPLLISLQQLIEQAGAQLPTSLQGVKSPDSGFKKRRYSGNKSAATTKSATAKKASAKRVSTTKAKRATS
(740) DNA topoisomerase 1 [Shewanella pealeana ATCC 700345]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSSSDAKVVSKTAAEVKKMSPEEKAEYKSLKAKQALVARMGVDPEKGWKANYQTLPGKEKVVKELQTLAASADHIYLATDLDREGEAIAWHLQQVIGGDESRYQRVVFNEITKTAIQDAFSQPSVLDTNMVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAELNTLTDDLLKMQVVKFQGKAFSPVNEVEAQTAVSQLSQSSFVVAAREDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVRDMIGKEYGDNYLPESPIRYGSKEGAQEAHEAIRPSNVKVSAASLSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGDYELKATGRTLRFDGWTRVQTAIKKKNEEDNTLPYVAQGDAVTLKELLPKQHFTKPAPRYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVDNRRFFAEKMGEIVSDSLVGSFEDLMSYDFTASMEQTLDDVAQGKLEWKKVLDGFYKDFTKQLEVAELPPEEGGMRPNEMVITDNIKCPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTLNLTPGEEAVSSGEDAETEALRAKHRCGICGTAMDSYLIDEARKLHVCGNNPTCNGYEVEAGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNTECKNTRKLLRSGEAAPPKEDPIHLPELKCTKSDAYFVLRDGAAGIFLAASTFPKSRETRGPLVEELVKYRELLWPKYQYLADAPVADDDGNLASVRFSRKTKEQYVATDVDGKATGWTSKFVDGKWVTEAKAKPKPKAKAKPKAKPKAKATKAE
(696) DNA topoisomerase 3 [Shewanella sediminis HAW-EB3]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGHIMAANGDCVSWCIGHLLEQAEPDHYDPLFKSWKFEHLPIIPQQWKMKAKPKTRSQLTVLRGLVKKASQLVNAGDPDREGQLLVDEVIAHLGVKGEKLNNTQRLLISDLNPQAVKRALGQMRSNREFIPLSTSALARSRADWLYGMNMTRAYTLQGRKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFVSKPFFEVLANLTTDNKEAFKTKWQPSAACQPYMDEEGRVLAKGLAQNVVGRITNKPAEVTQVLAKDKKQNAPLPYSLSSLQIDAAKRFGMSAKEVLDTCQTLYERHKLITYPRSDSRYLPVEQFQQASQVVSAVSSGAAELLEGMTAPDTKIKSKAWNDKKVDAHHAIIPTEKTANLSQLGARERQIYLQVARQYLAQFYPPYLYSETEVHVLIEGGNFKTKAKQERALGWKQLFGRNSDKQKSNGPDSKNNSDDDEESSQVLPPLVKGQQLHSGMGELVEKHTQAPKHFTDATLLGAMTGISRYVTDPEIRKILKDTDGLGTEATRAGIIELLFKRSFLSRQGKSILSTEVGQGLINSLPMSATTPDMTALWESNLDAICRKEAKYLSFMSPLIASLSELITQAGSQLPSALQGVKAPANSFRKKRYSKSLGSGRKKSTTGSTSRTSATKKRASSKTQTKG
(1874) DNA topoisomerase 1 [Shewanella sediminis HAW-EB3]
9
MGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSSTEAKVATKTPAEVRKMAPEEKAIYKSIKAKQALVSRMGIDPDKGWKANYQTLPGKEKVVKELQKLAESADQIFLATDLDREGEAIAWHLQEVIGGDASRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEKESEIKAFVPEEFWDIHAQLETLNNAALKMQVVKFQDKAFNPVTESQAQTATSALSQSSFVVAARDDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDGVREMIAKEFGDKYLPEAPIRYGSKGGAQEAHEAIRPSDVSVQAASMKDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGEYELKATGRTLRFDGWTRVQTVVKKKNEEDNTLPVVAQGDKLNLQELMPKQHFTKPPARYGEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLVGSFKELMSYDFTASMEQTLDDVAQGELKWKKVLDGFYKDLTKQIEQAELAPEEGGMRPNEMVLTDNIKCPTCDRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSENSEDAETDALRAKHRCDVCGTAMDSYLIDEKRKLHVCGNNPICGGYEVEQGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNDDCKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFMAASTFPKSRETRAPLVEELVKYRELLWPKYAYLADAPVTDDDGNKATVRFSRKTKEQYVATDVDGKASGWASKFIDGKWVSESKKKAKPKAKAKPKEKK
(1369) DNA topoisomerase 3 [Shewanella halifaxensis HAW-EB4]
10
MILYIAEKPSLGRAIADVLPKPLKKGDGFIRAANGDCVSWCVGHLLEQAEPDAYSPEYKSWKFEHLPIVPDNWKMKPKSKMRGQIAVLRGLVKEATQLVNAGDPDREGQLLVDEIIAHLGVKGAKLQNAQRLLISDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPVLGLVVRRDGEIAEFVSKPFYEVFAHLATDNQERFSAKWQPSEACLPYMDEEGRVLSKGLAQNVVGRINGQPATVEKVTAQDKKQNAPLPYSLSALQIDAAKRFGMSAKAVLDTCQSLYEKHKLITYPRSDSRYLPVDQHGLAPSVIRAVLSGASELVSSCDEPNAKLKSKAWNDKKVDAHHAIVPTEKTANLSNLSQAEKQLYLQIARQYLMQFYPAYLYKETQVEIIIAGGLFKTKAKQEVALGWKQLLKLSAKASQEKSSSEKSQTDDDEHLANIPALKKGQILLCERGELLEKNTQPPKHFTDATLLGAMTGISRYVTDSEIRKILKDTDGLGTEATRAGIIELLFKRNYLTRQGKSILATEVGKGLIYSLPQSATTPDMTALWENNLDAISRKEAKYQSFMDPLVNSLQGLIEQAGSQLPTSLQGVKSPDGGFKKRRYSGKKSTTTTKSAIANKTPAKRASTAMTKTKKATS
(984) DNA topoisomerase 1 [Shewanella halifaxensis HAW-EB4]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSSSEAKVVSKTAAEVKKMSPEEKAEYKSLKAKQALVARMGVDPENGWKAKYQTLPGKEKVVKELQTLAASADHIYLATDLDREGEAIAWHLQQVIGGDESRYQRVVFNEITKSAIQDAFSQPSVLDTNMVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAELNTLTDDLLKMQVVKFQGKAFNPVNETQAQTAVSQLSQSSFVVAAREDRATSSKPSAPYITSTLQQAASTRLGYGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVRDMIAKEYGDKYLPESPIRYGSKEGAQEAHEAIRPSNVKVSAASLSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGDYELKATGRTLRFDGWTRVQTAIKKKNEEDNTLPYVAQGDAVTLKELQPKQHFTKPPARFSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSDSLVGSFQDLMSYDFTASMEQTLDDVAQGKLEWKKVLDVFYKDFTKQLEIAELPPEEGGMRPNEMVIADDIKCPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTLNLTPGEEAISEGGEDAETEALRAKHRCGICGTAMDSYLIDEKRKLHVCGNNPTCNGYEVEAGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDAYFVLRDGAAGIFLAASTFPKSRETRGPLVEELIKYRELLWPKYQYLADAPVADDDGNLASVRFSRKTKEQYVATDVDGKATGWSSKYIDGKWVTEAKAKAKPKAKAKPKAKAKKAE
(1636) DNA topoisomerase 1 [Teredinibacter turnerae T7901]
9
MGKSLVIVESPAKAKTINKYLGNQYIVKSSVGHIRDLPTSGSAKTTTDPKARAKQAALTRKMSAEEKEVYKQNKAREQLINRMGIDPDNDWQAHYEILPGKEKVVAELRKLADQADHIFLATDLDREGEAIAWHLQESIGGDPTRYRRVVFNEITKNAIQEAFKSPGMLDINRVNAQQARRFLDRVVGYMVSPLLWEKIARGLSAGRVQSVAVRLVSERESEIRAFIPEEYWEVKAQLDTSKGERAKYEVKRFKDEAFKPVNEAQAMAAKSALEGAAYKVTEREDKPTKSNPSAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVENCRTFIQQEYGDRYLPKAPNVYSSKEGAQEAHEAHEAIRPSDVTTRPNQLSGMERDAERLYNLIWQQFVACQMTSAEFTSSSLKVSAGDYELRARGRVIRFDGFMKVMPPVSRKEEDTLLPDVKVGDMLDLHEILASQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVHVENKRFYANKMGDIVTERLIESFSDLMDYGFTANMEAALDTVAEGDKDWLDLLNEFYADFTVKLEMAQNSAAGMRRNEPVETDIDCGNCGRKMQIRTGSTGVFLGCSGYALPPKERCKNTMNLVSGDEAVNIDEDEDAESRQLRQKRRCKICNTAMDSYLLDEQRKLHICGRNPDCDGYEVEQGVFKIKGYDGPLIECDKCGSDMQLKSGRFGKYFGCTNDECKNTRKLLRNGEAAPPKMDPVDMPELACEKVEDHYVLRDGASGLFLAASQFPKNRETRAPYIKELLPHKDEIDPKYAFLFKAPTQDDNGNDALVRYSRKTKEQYVQTEVDGKATGWKAFYDGGKWQVSGSAKPTKAAPKAKATRKKKS
(1588) DNA topoisomerase 3 [Pseudoalteromonas atlantica T6c]
10
MILYIAEKPSLGRAIAQGFSGQQQKHDGYITLGNGDCVTWCIGHLLEQAEPDKYDPAYAKWALQHLPIVPQDWILVPKKGTSKQLSVIKRLLKTASQVVNAGDPDREGQLLVDEVITYCKVKRDIIDNAGRLLINDLNLNAVKKSLTNIRPNREFTGLSISALARSRADWLYGLNLTRAYTLLGQRGGYSGVLSVGRVQTPVLGLVVRRDAEIAQFKSKPFYEVMATLATQTEQPSQTFTAKWQPSSACEPYQDEEGRVIVKKLAETVVNKTRGQPGVVESYTVKDKQSPPPLPYNLSALQIDASKRFNLSPKAVLTVCQSLYERHQLITYPRSDSRYLPMEHFSEATKVLSAIKANAPEQQSAVENANSKLKSKAWNDSKVDAHHAIIPTSRNKAISSLSGDEAKIYQLIATQYIMQFYGPHKYQEQVAVVTIAGGTFVAKAKATTDKGWLVLTKQNGVAIPENGQTKNEPALPTLVKGQALDCVDSQLVEKQTSPPKHFTEATLLAAMTGIARYVQDANIKKILKDTDGLGTEATRASIIDLLFKRQFMQKSGKEIHATPTGKALIYALPSESTQPDMTAIWEANLDKISQRKMRYQDFMQPLTHTIGELINASQRIDTSQFAGLASTKPAYKKKWRKKKKAS
(634) DNA topoisomerase 1 [Pseudoalteromonas atlantica T6c]
9
MAKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGKVPPKKPAKELKLLSEKKRESYLREHEYRKLVDRMGVDPKNDWEAHYEVLNGKEKVVNELKKLAKNADTIYLATDLDREGEAIAWHLQELIDDPSKDYQRVVFNEITKNAIQEAFSEPGKVNVERVNAQQARRFLDRIVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDVHADLVTAKQSDLRMQVAKYNDKAFKPVNKAQTDAALSDLEGADYKVVSRDSKPTQSRPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSKEAVDACRDYIGDNFGDKYLPENALKYGSKEGAQEAHEAIRPSNVLLKSESLSEMERDAQRLYELIWRQFVACQMTPAKYDASTIRVSANGYELTAKGRVLKFDGWTKVQNPQRKKGEEDFLLPDVKEGESLNLKQLDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLESKRFYAEKMGEIVNDRLLENFDNLLSFDFTAKMEQELDEIANGKVSWKDVLNDFYGDFEQKLHLAEKDPEDGGMRLNQAVPTDIACPKCGRPMNVRTASTGVFLGCSGYNLPPKERCTGTMNLTSGDEVIKVDDEEELETELLRAKRRCPICATAMDSYLVDETRKLHVCGNTPTCPGIEVEEGTFKIKGYDGPIIECDKCGSNMELKNGRFGKYFGCTNEECKNTRKLLRNGEAAPPKEDPVDLPELECTKSDAHFVLRDGASGIFMAAHNFPKSRETRAPLVAELARFRDRISPKFYYLADAPAKDPDGNDTLVRYSRKTKQQYVMSENEEGKATGWSAWYTDNKWTVEDKRKKAK
(681) DNA topoisomerase [Pseudoalteromonas haloplanktis TAC125]
10
MLPKPHKKSDGFITAGNGDVVTWCIGHLLEQAEPEAYNPDYKKWAVEHLPIVPNEWKLVVKSKTRKQFTVVKTLIKKADTLVNMGDPDRVGQILIDEVINHCGVSKAKKTQVLRCLISDLNPAAVKKALNNLRKNTDFIPLATSALARARADWLYGINMTRLCTLQGRQSGYNGVLSIGRVQTPVLGLIVHRDLEIANFVSKPFYEVICTLLTSKGEAYQAKWRPSKACEPYMDEDNRVLSKPLALNVISKVQNKAGKVVNVTQAKKATPPPLPYSLSALQIDAAKRFGMSAQSVLDTCQQLYERHKLITYPRSDCRYLPKEHLNDVKQVVGAIGKSCSALSDAANNANLSLKNKAWNDSKVSAHHAIIPTSKSTDLSRLSPAENNIYELVARQYLIQFYPPFEYVDKQIDTEVSGGLFISKQKDVVSQGWKALFPSKQKSQAESEFSAVSLPNVSKGDEVHCQQADLIEKQTTPPKYFTDATLLSAMTGIARYVTDASIKKVLRDTDGLGTEATRAGIIELLFKRQFLTRKGKDIRATDVGTQLICSLPERMTIPDMTAHWESQLEAISQKEIKYAHFMDPITQSIDTLIAEVKTVTFNGLKGKGTPYKSKKYFKTKTKVNKKNVERL
(1089) DNA topoisomerase 1 [Pseudoalteromonas haloplanktis TAC125]
9
MGKSLVIVESPAKAKTINKYLGNDFIVKSSIGHVRDLPTSGSGKNKVPATKTPAEVRKLPPEEKAAYKKQRDYSNLVARMGIDPDKGWEPHYEILPGKEKVVQELKKLAENADQIYLATDLDREGEAIAWHLQEIIGGEPAKYKRVVFNEITKNAIQQAFETPGELNTDMVYAQQTRRFLDRVVGFMVSPLLWAKVARGLSAGRVQSVAVRLLVEREREIKAFIPEEFWDIHADVKNAESELRLEVAKQADKPFKPVNEAQASAAVKSLENAEYKVISVDEKPSKSRPSAPLITSTMQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKDAVAMCREYVTEQFGEKYLPKDPINYSSKGNAQEAHEAIRPSSVTVLSGHIEGVDADAKKLYELIWRQFVACQMVPAEYDLTTLTVAANDFQLKAKGRVLRFDGWTKVQPAIRKKNEEDQSLPAVTVGETLTLIELDPKQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFFAEKMGEIVTDRLVENFEDLMNFDFTAKMEGRLDDIAEGERIWTEVLDKFYADFSTQLTVAKDEPENGGMRLNEMVETDIECPTCSRKMGIRTASTGVFLGCTGYNLPPKERCTTTMNLVSGDEAVAADSADAEDLETETLMQMKRCPICETAMDSYLIDETRKLHVCGNNPACSGHVVEQGTFKIKGYDGPLIECDKCGADMELKSGRFGKYFGCNNDECKNTRKLLKNGEAAPPKEDPVHITELECEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPKVEELQRFRDRISPKFYYLADAPAQDPDGNLAVVRYSRKNKEQYVMTEVDGKATGWTAHYVAGKWVEEAKKKAAPKKKAAAKKAPAKTKAKAKTKKDDE
(1830) DNA topoisomerase 1 [Brucella suis VBI22]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRITNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRNIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1853) DNA topoisomerase [Colwellia psychrerythraea 34H]
7
MKLYIAEKPSLGRAIAAALPKPQKNHKTHIELANGDVVSWCIGHILAQADPEDYDAELKKWRMESLPIVPQQWQLKPIARTRSQLTVLRKLVKQADEIIHAGDPDREGQLLVDEVIDYFKLSKTKKANIKRLLISDLNLPAVKRALTSLKPNSDFMPLSISALARSRADWLYGINLTRAYTLQGQKTGYNSVLSVGRVQTPLLGLVVRREQEISEFVSKPFFQVQAHIALSSKDAVAFTAKWQPSENCQPYCDEEGRVLVKALAENVVKRIANQPATISNIDSNEKQQAAPLPFNLSQLQISAAKQFSMNAKLVLDVCQALYERHKLITYPRSDCRYLPKEQLKQASGIVNTLANSSLPCNKPAQGANTSFVSKAWNDKKITAHHAIIPTEKSPENINLNTFEKNVYLLIVRQYLVQFYPAYIFQQTKVELLIAGGNFMSQAKTEKQLGWQVLFPKSNKTNNQSKLEHGQEQEQTLPPLTKGQLLHCQQGELIEKHTSPPQSFTDATLLGAMTGISRYVNDAAIKKVLKETDGLGTDATRAGIIDLLFKRGFLQRQGKAITATKVGVALITALPTMATLPDMTAQWEATLTAISEKNANYLSFMQPLTVIVNEMVQGASQQSFSGLPKVAFKPKRGKRTFQKKAVKKAS
(1179) DNA topoisomerase 1 [Colwellia psychrerythraea 34H]
9
MAKSLVIVESPAKAKTINKYLGNDFIVKSSVGHVRDLPHSSTGKKVAAKSPAEVRKMEPAAKAKYKAKRDKQALVNRMGIDPDKNWAADYQILPGKEKVVAELKKLADKADIVYLATDLDREGEAIAWHLKEIIGGEDEKFRRVVFNEITESSIQQAFATPGELSMPGVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEKEREIKAFDPKEFWEIAVDTHASTGEVLTLDVTHENGKAFKPTTEKETNAALAILKPADYAVSKREDRPSKSTPSAPFITSTLQQAASTKLGYGVKRTMGLAQRLYEAGHITYMRTDSTNLSKDAVEMCRKYISDSFGDNYLPENAKTYGSKAGAQEAHEAIRPSNVKLEAAFLEGIEADAKKLYELIWRQFVACQMTAARYTVSTLTISAASFDLKAKGRVMQFDGWTIVHPQLSKGDDTHLPDLQVGEALTLDKIEPSQHFTKPPARFGEASLVKELEKRSIGRPSTYASIISTIQDRGYVRLDKKRFYAEKMGEIVTNSLSGSFEKLMSYEFTSNMEQELDEIAGGSADWKGVLDEFYKNFTKQLSKADQPSEDGGMQTNEPVLTDIDCPTCNRKMGIRTAQTGVFLGCSGYALPPKERCTKTMNLTAGEEAVSILAEDAETEALMAMRRCDKCGTAMDSYLIDETRKLHVCGNNPVCDGIEVEKGEFKIKGYDGPILDCDRCESPMELKSGRFGKYFDCTNEECKNTRKLLASGEAAPPKEDPVQLPELECEKSEAHFVLRDGAAGIFLAAHTFPRSRETRAPKVAELQRFRDRISEKFYYLADAPAEDNEGNLSVVRYSRKTKEQYVMTEIATEEGKPKATGWTAKYIDGKWIEDIPKKKVAKKKAAKKPAAKKKAKTAAE
(84) DNA topoisomerase 3 [Psychromonas ingrahamii 37]
7
MKLYIAEKPSLARAIADALPKPHRKADGCIYVGNGDVVSWCIGHLLTQVDPEAYDPEYKKWKFEHLPIIPENWKLKSTPRTSKQLSILKKLIKQADNLVHVGDPDREGQLLVDEVIHFSGVKGNKLKQVERCLVSDLTTNAVKRSLQQLRSNQEFIALSTSALARTRADWLYGLNLTRVYTLQAQKSGYQGVISVGRVQTPLLGLVARRDKEIEVFVSKPFYEVEAHLTTLKPENVAAFTAKWKPSEACEKYQDHEGRVLVKKLAENVAQRISQQHAVVKSFTAKNKKQVAPLPYNLSALQIDAAKRFSYTALEVLDICQALYEKYKLITYPRSDSRYLPKNHLSQAGSVTRAIANNQPALKKAVSNADISLQSRAWNDKKVDAHHAIIPTDKHQSLTSLDTASQNIYALIARQYLCQFYADYHYGECVAEIEINNGLFISKAKAKISDGWKVLFDKQEKDSYLPALSKGQKLFCDKGEVIEKNTQPPAYFTDATLLAAMSNIARYVKDGELKAVLKETDGLGTEATRAGIIELLFKRLFLQRTGKLIKATETGRKLIESLPEMLTLPDMTAQWEMELNAISQKEQSYQGFVVPLQNQLKSIIEKAIADGPRALANLPSSGNVFKKTYRKKSTKKGTFKKKGS
(1563) DNA topoisomerase 1 [Psychromonas ingrahamii 37]
9
MSKFLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSGSAKKKIEAKGTKSLAGMTPAKKEKEKAKRTQSALVARMGVDPNDHWKANYEILPGKEKVVAELQKLAVDAPIIYLATDLDREGEAIAWHLREVLGGEHQKYKRVVFNEITETAIQEAFEHPTELNIDGVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERERLIKVFNPVEFWDLHADVQDKTKSDLRLEVFKENGKFFKPVTETETLKAVDHLKSAEYKVLSREDKPTTSKPSAPFITSTLQQAASTRLSFGVKKTMMLAQRLYEAGYITYMRTDSTNLSKEAVGSARDFISDEFGKNYLPAEPVVYSSKSGAQEAHEAIRPSDVGQLAALLVGVDRDAQRLYELIWRQFLACQMLPALYDATTLVVQAGDYQLRAKGRTLRFAGWTKVQPVAKTQVDEVQFPELAIGEVLELVELDPKQHFTKPPARFTEAALVKELEKQGIGRPSTYASIISTIQDRGYVKVDKRRFYAVKMGEIVSDRLSENFVELMSYDFTAQMERNLDAIAEGKANWTEQLDDFYQDLTTLLEKAERDPEEGGMRLNEPVIIKEIHCPTCDREMGIRTASTGVFLGCSGYALPPKERCKTTINLVDGEEVVDLLSSEDLETAALMAKQRCPKCDMAMDSYLVDEKRKLHVCGNNPLCDGHLVEYGEFKIKGYDGPVVECDKCGSDMQLKDGRFGKYMGCTNEECKNTRKILRSGEVAPPKEDPVDLPELECEQSDAHFILRDGASGIFLAANTFPRSRETRAPKVAELARFKDRISPKFYYLAEAPQKDPEGNLAVVRYSRKNKEQYVMTEIDKKATGWTAKYIDGKWVEEQTKKRAVKAKK
(1068) DNA topoisomerase 1 [Idiomarina loihiensis L2TR]
9
MAKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTRATETIKSKPAAEVRKMSPDAKAKYQKERDYKRLIARMGVDPENDWEAHYEVLQGKEKVVKELKQLAKKSDEIILATDLDREGEAIAWHLRELIGGDDSRYKRVVFNEITKKAIQEAFQHPAELNTDRVNAQQTRRFLDRVVGFMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWDVHADLNTPADESLRMQVMKQAGKNFRPSNKQETDAALALLKKAGYEITGREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSSEAVDACRELITKDFGKNYLPDDPVRYGAKSNAQEAHEAIRPSDVKVKSESLASVERDAQRLYELIWRQFVACQMVPARYDSTTLTATAGDFELKARGRVMRFAGWTKVMPPASSKKDGDATLPDVKKGDALQLEKLNPEQHFTKPPARYGEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFFAEKMGEIVNDRLIENFTELMNYNFTAEMEQALDDIAAGKRDWKETLDKFYADFKERLEKAELEPTEGGMRENSMVLTDIDCPECGRKMGIRTASTGVFLGCSGYNLPPKERCTKTLNLTPGEEAIEVTDEEERETEALRAKKRCPKCGTAMDSYLIDEKRKLHVCGNNPTCDGQLVEEGTFRIKGYDGPTIECDKCGSEMQLKTGRFGKYFGCTNSECKNTRKLLRSGEAAPPKEDPVPLPELPCEESDAYFVLRDGASGIFLSANTFPKSRETRAVTVKELAKFKDRLPEKFKYLAEAPKEDDDGNDAIVRFSRKNKEQYVVTEIKKKQTGWKAFYRSGKWQVEEK
(1690) DNA topoisomerase 1 [Brucella melitensis NI]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEILRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYPRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(1124) DNA topoisomerase 1 [Acidithiobacillus ferrooxidans ATCC 23270]
1
MTKLLIVESPTKAHHIQAMLGSGWSVKATVGHIRDLPIKGDAAYVRPPDFKLNYEITERASKTVPALRAAARDAESVYIATDPDREGEAIAWHVCQVLGIKPGAAKRVTYQEVTEPAIRKAIAAPRTVNMPLVAAQEARRALDRIVGWEVSGPLSNAIGSRASAGRVQTPALSLVVAREQAIRQFKPTPWFQVLAHVAGKDAAPDWRAVWVDGTQEGEYFQDKAHAKALADALPSMALKVTKAETKPVRKPPAPPFTTSSMQMDGARALKAPVDAIMKAAQSLFEHGHITYHRTDSPNLSEEGEGLLRAALKKENLPLVETPRRWRSKGGAQEAHEAIRPTRPMVRQAGENDLEQALYDLIRKRALASQMPDAVYQQTSCTLDGGMFQGRPAVFRAVGSVLKDPGWMALYRETAEDEEGTENPAANPVPRLAVGDAVRAARGECLSKTTKAPPRYTESTLIKALEDHGVGRPSTYASILKNLFAREYIRRKGKSPALYATELGEKIVEALSVFDFSNVDYTREVEADLDRITEGQMRPRDLLAKSFADIQRILDAMPTQARAQGRPCPIEGCDGTVRRLESKRKPGVFFWMCSNRDAHPLLQDNDGEPGAPFAERVEAGDGPACPECGAATSRQETGKGYGYFRCGKGHGSWWDDKGSLGKKWEDRAPAQGAASGPARKNTGSKASSTKRPTKGTRTKARSSIMD
(228) DNA topoisomerase III [Acidithiobacillus ferrooxidans ATCC 23270]
7
MKLYIAEKPSLGKGIAEYLPGSKNKGNGFIQCGVDTVVTWCFGHIFEQEEPDFYTPDDVPTTPKGKKKWRFEELPIFPEQWKKRAKDDAKAQIKVIRALLKKASSVVNAGDPDREGQLLVDEVLEELRWKGPTLRIWLAALDEQSVRKALASLKDNHDYQNLRNSAEARARADWLMGMNLTRAFTLRNSGAGVVSVGRVQTPTLALVVARDEKIEHFKPKDYYVPRINAGFWATWELREDFEGVDAEGYLTDRKAADRLASRAKAEGKATVKDFTSAEKQQQAPLGFSLAELQKVCSAKLGMSAQSVLDAAQALYEEHKAATYPRTDCRYLPEEQHGDAGQILSGLAKAGFADLVKAADSNRKSAIWNTGKVTAHHAIIPTGSMQGSMSPAVAKVYDIIVRSYLAQFYPPYVYRAIKALLTCTSEDWKATANIPVSAGWKAVYGMTDDDNDDTPAQPIPALKKGQVLTVQDADVQAKQTKPPARFTDGSLIEAMSNIHKVVEDEAAKAKLKETSGLGTEATRASIIETLLTRGFLERKGKQILSTQAGRALVHALPKDLTDPVLTARWEDALSSVSEGRVTLQQFEEAQRKFVVRMIEAAKATTVAVGQARPTSGAGRGKSSTGKTRGVGQKTGPACPDCKKLTITLKTKKGDAFFKCEGCQSCWWPDKQDAKKLGTKWGLEKNEYVRREDWISHTQQD
(782) DNA topoisomerase 1 [Acidithiobacillus ferrooxidans ATCC 23270]
1
MAHQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDLQPKEGAVDTEHDFAMRYTPIERNERHVDAIAKALRGADKLWLATDPDREGEAISWHLVELLRERQLLGDKPTQRVVFHEITKKAVQEAIAHPREIAMDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASRLQHAGSAFTGRLTHWQNKKLEQFDIADGDQAQAIRSGMEDDLGRQALRVREVERKSRQRQPAAPFTTSTLQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRTFIDGYYGSEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPESLQGVLERDLWRLYDLVWKRSIACQMAPARLDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDESNRILPPLDVGDEPLVLGIDPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQRRFHPTDLGRVVGRFLINHFERYVDYGFTASMEDELDAVSRGEKQWQPVLSAFWSPFRALLDEKANVSRAEATSEALEEACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAEPVGRDCPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQPKSSGVTCPQCGEGELVEKRSRYGKVFYSCNTYPKCTYAVWGPPVARPCPRCGWPIMIEKSGKRLGEQLACPQSECAFHFPANASDAEIAALLPGYSPPPPREKRAPPAKKAAPARKTTAKTAKKPATEATAVAAQKTAKAKTTSAAAKKPAASKARGPSAGEGKTSPSRKRAAKGASDS
(1438) DNA topoisomerase [Acidithiobacillus ferrivorans SS3]
7
MKLIIAEKPSLAKAIREVVGKEYTVTNAFGHILEQAGPDEYTPAEVPVNPKTSKKRWRLEDLPIFPQTWIKHPKPDAKEQLMKIKGMLKEAALVVNAGDPDREGQLLIDEILEYCGYRGPVQRVWLASLDETSVKKAFANLRDNKEYRTLSQAAEARSQADWVVGMNLTRAWTIKNNGLLSVGRVQTPTLALVVRRDLEIEQFKPRDFFEVIAHCRHQNGEFVVKWRPAVNDGPGFDEEGRLVGRQLADSIAAKAAGHGKIARYDAKDSKQSAPLPFSLSALQKAASAKFGMSANQVLETAQSLYEMKITSYPRSDARYLPEEQYSDAGRILSHLPIPDPLKAKVLANRKHAAWNTGKVTAHHAIIPTGDRAAGLTDAEQKIYDLIWKSYVALFLPDYLYKAISVAVDLGGEQWTTSGRLDMDMGWKALYGASAADDDEDGDGEGKAKLPSMTTGDAIAGQKGEVQAKQTKPPARFTDGTMIEAMSNIHKFVTDATAKAKLKETSGIGTEATRANHLSSIADGKLDPNKFMGAIQQMVREQLGKVTAGVSVSGGKSGGGSGGTKKVGPQCPDCKAATIILKTKTGKPFVKCEKCGSAWWPDRNDPKKLGSKWEARK
(126) DNA topoisomerase 1 [Acidithiobacillus ferrivorans SS3]
3
MSALLIVESPKKAQHIGHILGNGWQVKATLGHIRDLPVTGEAAYVRPPDFAMRYEILDTKHKEIVSGLRAAAQSADAVYIATDPDREGEGIAWHVCQVLKIKPGEAKRVSYQEVTETAIRKALLAPRPVNMRLVAAQEARRALDRMVGWEVSPVLSNSIGAKASAGRVQSPALALVVERERAIKSFKPTAFYQVLAHMPGKDGVSGWRASWIDGTKEGEYFQDKAFAQALADALPSMPLVVSKAESKPVRRAPAPPFTTSSMQMDGARALKVGVEDIMKAAQALFDNGHITYHRTDSPNLSEEGEGLLRAALEKTGLPVVDKPRRWKAKGDAQEAHEAVRPTKPMLEEAGEDANQRALYQLIRKRALASQMPDAIYQQTSCTLNGGTFHWRDLSHPALFRAVGSVLTDPGWRALYTESEDEGEGKETEAANPVPKLSVGDKLKAERGEMVSKKTKAPPRYTESTLIKALEDHGVGRPSTYASIIKVLYKRDYMKRKGKAPALYATDLGEQVVDALRPFDFAGLEYTRLIEESLDLITEGKMPPRDLLAKSYADIQSTIATMPKGADNSQPCPVDGCGGTVSRRESKKKKGSFFWACSNRDNHNLLQDKDGTPGEPFGDKVESNTDGPACPECGKPTGRYETSNRHGFFRCAKGHGTWWDDKGAIGKLWETLPAGKGGKAKPEAAAKKSAGKPARKRTGKPAARRSTIMD
(687) DNA topoisomerase 1 [Acidithiobacillus ferrivorans SS3]
1
MAYQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDLQPKEGAVDTEHDFAMRYAAIERNERHVDAITKALRGAEKLWLATDPDREGEAISWHLVELLRERHLLGNMPTQRVVFHEITKKAVQEAIANPREIAMDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASHLQQAGSDFSARLTHWQDKKLEQFDVTESDQAAAIRSGMEDDLSRQPLRVREVERKSRQRQPAAPFTTSTLQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRDFIGGHYGGEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPEALQGVLERDLWRLYDLIWKRSIACQMAPARMDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDEGNRILPPLNTGDEPQVLDINPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQRRFRPTDLGRVVGRFLTNHFERYVDYGFTASMEDELDAISRGEKQWQPVLSAFWGPFRALLDEKANVSRTEATSEALDEACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAEPVGRDCPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQPKSSGVTCPECGEGELVEKRSRYGKIFYSCNTYPKCNYALWGPPVARACPRCAWPIMIEKSGKRLGEQLACPQSECAFHFPANASDTEIAAMLSDYTPPPPREKRAPPAKKAAPARKAAAKSTRKPAVKAATAANKPAKAETTAAVVKKPSKAKTPAAKKSTSSKNTTSSASEAATPAARKRSVKNVTNS
(981) DNA topoisomerase 1 [Legionella longbeachae NSW150]
1
MSKHLVVVESPAKAKTIQKYLGNDYEVIASYGHVRDLPARKGSVNPDKQFAMTYVPIEKNARHIETIAKILKKSDSLLLATDPDREGEAISWHIYELMKEKNLTKDKTVHRIFFNEITKSAIQDAINHPRTISMDLVNAQQARRALDYLVGFNLSPLLWKKVRRGLSAGRVQSPALRLIVEREEEIESFVAQEYWKILAQCFHANSPFEARLTHYKNEKIQQFTIVNQEQAQQIKEFLIDQAKGSLFVTNIEKKQRKRKPSPPFITSTLQQEAARKLGFTARKTMMVAQQLYEGIDIGTGTVGLISYMRTDSVNLSVEAIEEIRQFITERFGAANCPTSPRAYKTKSKNAQEAHEAIRPTSIKRVPEMVQSSLTTDQYKLYNLIWKRTIACQMADAVLDTVAVDLTCGEGTIFRANGSTVTFPGFLSVYEEGRDDAKDDENDGSLLPVLVVGEKVNVQDILANQHFTEPPPRYSEATLVKALEEYDIGRPSTYATIIHTLQQREYVVVDKKRFFPTDVGRIVNRFLTGYFTRYVDYKFTAELEDTLDAVSRGEKEWIPVLDEFWKPFVQQIKTTDEQVQRKDVTSEVLDEKCPKCEKPLSIRLGKRGRFIGCTGYPECDYTQDIAGQENEKKEPEVIEGRVCPECSSPLHIKVGRYGRFIGCSNYPQCKHMEPIEKPADTGVDCPKCHQAKILQRKSRKGKIFYSCGNYPKCDYALWNEPINQPCPKCNWPILTVKESKKFGRQILCPQEGCGHSTKEE
(1371) DNA topoisomerase 1 [Coxiella burnetii RSA 493]
1
MVKSLVVVESPAKAKTIEKYLGKDFKVMASYGHVRDLIPKEGAVDPEDHFKMHYQAIERNIRHMDAIAKALKPCHNLYLATDPDREGEAIAWHVKQMLESRNGLKDKKFSRVVFHQITKKAVQHAIENPRDISMDLVNAQQARRALDYLVGFNLSPLLWKKIRPGLSAGRVQSPALRLIVEREIEIENFESQEYWTIHADCHAQQQPFDARLIEFQGEKLEQFSIVNEKQAHETRDAITQAANGKLTVAKVVKRERKRNPAPPFITSTMQQEAARKLGFSASKTMQIAQQLYEGVNLGEEGAMGLITYMRTDSVTLASEALQEIRQLIEEKYGQENVPEQTRIYKTKSKNAQEAHEAIRPTSAFRTPENLKKYLNSDQLKLYTLIWKRTIACQMIEATLHTVAVDLKAPNAIFRANGSTIVKPGFISVYQETFDDKKKEEESDSKMLPPLEEGQTVDVNEIKSEQHFTEPPPRYTEASLVKALEEYDIGRPSTYASIIATLKNRKYVDVDNKRFIATDVGRIVNRFLTHYFTKYVDYGFTAKLEDELDDIARGEKTWIPVLETFWSPFKNLVDVTEKTVKRSDVTQEKIDEKCPKCSAQLSIRLGRRGRFIGCTAYPDCDYTRNLTEIAAEAQAVLEGRQCPECQSNLIIKMGRYGKFIGCSGYPNCKYMEPLEKPKDTNVTCPKCKKGTILQRKSRRGKIFYSCARYPDCDYALWNEPVAEACPKCGWPILSIKTTKSRGTEKVCPQKSCNFIEAYDGDKPSLD
(448) DNA topoisomerase 1 [Alteromonas sp. SN2]
9
MAKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGKVEPKKPAKELKTYSEEDKQEYLRRHEYLKLVDRMGVDPEQNWKAHYQVLQGKEKVVNELKRLAKDADTIYLATDLDREGEAIAWHLQELLGSKGKTYQRVVFNEITKNAIQEAFSDPGEVNVARVNAQQARRFLDRVVGFMVSPLLWKKIARGLSAGRVQSVAVRLVVDREREIKAFVPEEFWDIHADLTSEQKAALRMLVAKHEGKAFKPVNKAQADKALEDLNGAKYLVESRESKPTSSRPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQEALDNCRAYIDDNFGSQYLPESPNRYGSKEGAQEAHEAIRPSSVKVNAAHLGDMERDAQRLYELIWRQFVACQMTPAKYDATTIRVGAGNYELTAKGRVLKFDGWTRVQPQLRKKGEEELMLPDVQKGDVLNLNALDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLENKRFYAEKMGEIVNDRLMENFDDLMSFDFTANMEQQLDDIAEGNKDWKDVLNLFYSDFYGKLLNAEKAPEEGGMRLNQAIPAGITCDKCGREMNVRTASTGVFLGCSGYNLPPKERCTNTMNLTPGDEVVKVDDEEELETEALRAKKRCPICSTAMDSYLVDETRKLHVCGNTPTCEGTLVETGTFKIKGYDGPIIECDKCGSDMELKNGRFGKYFGCTNEECKNTRKLLRNGEAAPPKEDPVDLPELPCEKSDAHFVLRDGASGIFMAAHNFPKSRETRAPKVEELARFRDRISEKFYYLADAPQKDPEGNLAIVRYSRKTKQQYVMSENEAGKATGWSAWYNDGKWETQAASKPAAKTKAKAKKK
(51) DNA topoisomerase 1 [Stenotrophomonas maltophilia R551-3]
1
MPKHLLIVESPAKAKTINKYLGKDYTVLASYGHVRDLIPKEGAVDPDNGFAMHYDVIDKNEKHVDAIAKAAKSADDILLATDPDREGEAISWHIAEILKERGLVKDKPMQRVVFTEITPRAIKEAISQPRAIASDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIAAECAHPSQHFNAKLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGALHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVAIGDEGTVGLISYMRTDSVNLSQDALAEIRDVIARDYGIASLPDQPNTYQTKSKNAQEAHEAVRPTSALRTPAQVSRYLTDDERKLYELIWKRAVACQMIPATLNTVSVDLSAGSDHVFRASGTTVVVPGFLAVYEEGKDNKSAEDEDEGRKLPAMKPGDRIPLERIVADQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVEMEGRSFRPSDVGRAVSKFLSSHFTRYVDYDFTAKLEDELDAVSRGEEEWIPLMSRFWEPFKELVEDKKESVDRAEASGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEEKPKFASLRPGQSMHTITLEDALELFLMPRALGEDKGEDVSVGIGRFGPFAKRGSTYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKEFEGSDIQVLNGRFGPYISDGRMNGKIPKDREPASLTLAEVQQLMEETGKPVRKGFGKKAAAKKAPAKKAAVKKEAAPKKAAAKKAPAKKTVKKAAAKKAPAKKAVKKAAK
(941) DNA topoisomerase [Marinobacter aquaeolei VT8]
7
MHLYIAEKPSLARAIAAALPGPHEKGQGWIRCGKGPDAATVSWCIGHLLEPAEPARYNPAWKKWRIEDLPMFPEPWQLTPKDSVRLQFKVLEALVRKADLITHAGDPDREGQLLVDEVLRYLGTKAPVKRILINDLTPKAVARAIQNPRDNREFRPLSHSALARQRADWLYGINLTRFYTLSYQTRGEQGVFSVGRVQTPVLGLVVDRDNTIEHFQPKPWYRVEATFQASEPEADQRPFIARWLPGDEFQDHLDEENRLLDKSVAEQIVAAISGRPGRIDEARFRDRPEPPPLPLSLSALQIEAGRLYRMGAKDVLDTAQNLYERHQLITYPRSDSRYLPEEHFSQREAVIRAIARVAPDLSGFCEKTGTERRSAAWNDQKVDAHHAIIPTVRPAPNGKLSSAEQKIYDLISRFYLMQFAPDAVHREGRLTVAIQDYRFRATETAVIEPGWKTLEIRKREPGQEPEKAPLPRLEKNEPVLCTDPQTNERKTQPPQHFTDATLLSAMTNIARFVADNELRKTLRETDGLGTEATRAAIIDTLFRRDYLFREKRFIRATDKGKSLIAALPESIRTPDRTAVWEATLEGVRRGEEDPRAFLESLKDEIRGFMAQAPAAGLANTETPGTAIHCPKCRAPMVEREGKFGAFFACTRYPACKGTRPLEDHQPEDGTSQKPVPCPHCFSPLVRRKSNKGWFWGCSNFPGCRQTVDDHNGRPAVDLRNST
(135) DNA topoisomerase 1 [Marinobacter aquaeolei VT8]
9
MGKSLVIVESPAKAKTINKYLGSDFIVKSSVGHIRDLPVSGSGSQSDPKERAKQAAATRKMSPDEKAEHKKRKAREQLVARMGVDPDHDWSARYEILPGKEKVVSELKRLAKSADHIYLATDLDREGEAIAWHLQETIGGEPDKYRRVVFNEITKRAIQEAFKDPGNLDNNRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVRLIVEREREIRKFVPEEFWQLHADLAAEGAKDPVRFEVTRYIDKPYRPVNEAQSKEHVERLKAGGFKVAKREDKPTRSRPSAPFITSTLQQAASNRMGFSVKKTMMLAQRLYEAGFITYMRTDSTNLSQDAVVSCREFVQKQFGERYLPEKPRVYGSKEGAQEAHEAIRPTDVARRPTDITGLEKDAEKLYDLIWRQFIACQMADAEFLSTSIVVANGDYELRTRGRIVKFDGFLKAAPQSTKKDEDVALPDIKVDQPLDLKKLDPTQHFTKPAPRYTEASLVKELEKQGIGRPSTYASIISTIQDRGYVKLQNRRFYAEKMGEIVTERLAESFPNLMDYDFTARLEDELDEIAEGEVQWKKVLNDFYAKFRNQLESAEKTDGGMRANTPTETDIPCPSCGRNMQIRVASTGVFLGCSGYSLPPKERCKTTINLVSGDEVVSADDDVEGEGETRLLRKKRRCPKCGTAMDSYLIDEKRKLHVCGNNPDCSGYEVEEGTFRIKGYDGPTLECDKCGSEMQLKTGRFGKYFGCTNSECKNTRKLLKNGEPAPPKMDPVPMPELKCDKVDDTYVLRDGASGLFLAASKFPKNRETRPPLVMEIKPHRKEIDPKYDYLMDAPEKDPEGNPTVIRYSRKSKEQYVMSEKDGKATGWSAWFENGRWVPRDKKK
(1322) DNA topoisomerase [Haemophilus ducreyi 35000HP]
4
MRLFLCEKPSQGNDIAKVLGATKRGDGCLSSGNGQVFVTWGIGHLVEQLNPEQYHPEWKKWSLETLPIIPGQWQLAPKKETKKQYNIVIKLIKQASEVIIATDIDREGETIARELLELAGFKGKIQRLWLSALDDASIRKALALLKPNHETLPLYYAGLGRSRADWLIGMNFSRLFTLLAQQQGYQGKPLSVGRVQSPTLALVVNRDREIQNFVPKNHFTLSALLYSGQQNFTAQYVIPEQYCDEDGLCLSQQTIQAVNQQVQQAGVMKVESVETKREKQSAPLLFALSDLQSEANRLYGLGAQQVLDIAQSLYETHKATTYPRTDCGYLPESQLAEAPQVIKSLISSDSRLQPLTSKLNLTQKSRAWNDKKITAHHGIIPTAVKVDIGKMSEEEFRLYDLIRRRYLAQFLPVSQSDKTQIVLKCGVHTFISRGNVLIATGWKMLCGAPMTKRNGKNGQFWGCTAYPDCQHIENIGKSTARRKGTANSQNISQQIANLRKLVQ
(1513) DNA topoisomerase 3 [Haemophilus ducreyi 35000HP]
10
MMRVFLAEKPSLARAIAEVLPKPHIRGDGYIQCGEHDYVTWCIGHLLEQAEPDAYDERFKTWRMEHLPIIPQQWKLIAKKQTAKQLKVVEKLVKKAEILVNAGDPDREGQLLVDEVFNYLNVPASKKSQIQRCLVSDLNPTAVSKAINKLQNNCDFIPLATSALARARADWLYGINMTRAYTLQGRWVGYQGVLSVGRVQTPVLGLIVRRDLEIEHFTPKDYFEVLAHIIVPTTQERFTAHWQPSKACEDYQDEEGRVLSRALVENVVKRISDQTACVTDYQDKTESEIAPLPYSLSALQIDAARRYGLSAQAVLDICQTLYETHKLITYPRSDNRYLPNEHYNERFNVVAAIAHHLTEYQQKPEVVNLALRGRCWNDKKIEAHHAIIPTARQGNLRLTENEKRIYRLIACQYLMQFCPDAEYSKRKITLDIAGGTFIAQARNLVTAGWKALLGKEDCDEMIEPLLPAVQKAQRLHCEKREIISKKTQLPRHFTDASLLSAMTGIARFVQDKQLKKILRETDGLGTEATRAGIIELLFKRGFVTKKGRNIQSTETGRVLISALPDIATQPDMTAQWEMQLKQISQKQVSYQQFMHQLTTKLPELLHTDRQKLQKLNIITPLKLPAKRTHTKASIMADEK
(444) DNA topoisomerase 1 [Haemophilus ducreyi 35000HP]
9
MGKSLVIVESPAKAKTINKYLGSDYIVKSSVGHIRDLPKSGSEKAEKVKPISTKGLTAEQKAKVKADKARAALVKRMGIDPYHDWKANYQILPDKDKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGKEEHFSRVVFNEITKNAIQKAFEKPEQLNLDRVNAQQTRRFLDRIVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWDILANTLAENGRLPLALTSYKGKKFVAKNQTEADNAVKALQCCEFVVSDIDKKPTSSKANAPFITSTLQQTASTRLSFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALTMVREYVENHFGTDYLPAKPNFYSSKENAQEAHEAIRPSDVRVKMSDLKGMEKDAERLYDLIWRRFVACQMPPARYDSTSLTITAGDYELKAKGRVLRFDGWTKVLPIQGKTAEDQELPAVMLNEKLTLAEIIPSQHFTKPPAHFSEAALVKELEKRGIGRPSTYATIISTIQERGYVRTENRRFYAEKMGEIVTDRLDESFSDLMNYDFTANMEETLDQIAKGNKNWKEALNSFFSDFSEQLSKAELDELEGGMKPNSLVVTDIDCPTCARKMAIRTASTGVFLGCTGYALPPKERCKTTMNLILEAELFNVLDEESEAKALLARKRCPKCGSAMDSYIIDPTRKLHICGNNPNCDGHIVEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMACTACDNTSKILKNGEVAPPREEPTHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELALYRDRLPAKLQYLADAPQQDPEGNQAIIRFSRKEKRQYVTSEKEGKATKWIVDFIDGKWLERHK
(842) DNA topoisomerase 3 [Pasteurella multocida 36950]
10
MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGADDYVTWCIGHLLEQAEPDAYDPKFKQWRLEHLPIIPEKWQLIPRKDVHKQLTIVEKLIHQADILINAGDPDREGQLLVDEVFSYANLSVDKLNQIQRCLISDLNPSAVEKAVNKLQSNRNFIPLATSALARARADWLYGINMTRAYTLRGRQAGYQGVLSVGRVQTPVLGLIVRRDLEIENFKPKDFFEVLAHIQAETPEKITALSAQEKADIPQFKALWLPSKACEDYQDEEGRVLSLGLVENVVKRIAQQPAEVVEYVDKREHESAPLPYSLSALQIDAAKRYGLSAQEVLDICQRLYETHRLITYPRSDCRYLPEEHFAERTKVFQAISRHISDYQPLPDILNPEQKNRCWNDKKVEAHHAIIPTAKNTPVNLNQREWQIYHLIARQYLMQFCPDAEYRKSKITLNIAGGSFIAQARNLQVAGWKQLLGKEDSDEQQEPLLPVVKKGQILFCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTETGRILIQALPDVATQPDMTAHWESQLTSISQKEMSYQQFMSTLTNFLPELMRYVNFAALRQLSQVEKPPSFSKKTSAKSKKRPT
(914) DNA topoisomerase 1 [Pasteurella multocida 36950]
9
MSKSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAIQQAFEKPEQLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEYWEIDVLTQTQAKQALRLAVTQFKGKKFEPKNATQAQSAVDFLQHADYVVSDLETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALKMVRGYIQSHYGESYLPSKPVFYSSKENAQEAHEAIRPSDVNTLAEQLTGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVRAGEYELKAKGRILRFDGWTKVLPTMSKNAEDQVLPDVQLNEKLHLEHVLPEQLFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNQSFTALMNYDFTANMENILDQIANGEKNWKTELNQFFKDFSQQLSQAELDELEGGMKPNSLVPTDINCPTCGRKMAIRTASTGVFLGCSGYALPPKERCKTTMNLIPEAELLNVLDEASETKALMERKRCPKCGTAMDSYLIDPERKIHICGHNPNCDGYVLEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMGCTSCDNTRKILKSGEVAPPKEEPTHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELALYRDRLPEKLRYLADAPQHDPEGNDAIVRFSRKEKRQYVTSEKNGKATKWIVDYLGNQWVERKK
(876) DNA topoisomerase [Pasteurella multocida 36950]
4
MKLFICEKPSQARDLAGVLGATSKGEGLLATADKSIIVTWGFGHLVEQYQPEDYDEAWKRWAFETLPIIPAQWKMTPKKESKKQYSVVIGLIKKATSVVIATDADREGEMIARELLDLAGYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLMAQAKGYSGKPLSVGRVQSPTLTLVVNRDREIANFVPKSHYALAVQLTTTSGETFVAGLAVPEQYLDESGLCLDSRVIQQAEAQIKQTGLAKVVTVETKREKKSPPLLYALSDLQGECNRLFGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQFSDVPNVIRSLVASDSGLQTLLPKLNLRQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLEMDKTVATLQSSGHTLVARGNVIVAQGWRILFGKNVDEETGNDDEKQGLPVLTKNQQCNVTHSEVRTLQTKPPAHYTEGTLLDAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKGFLLKKKKSLVASAEAVALIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDAFMQKQEAFVKQLIGSCMQQGMSLGNIEIRKCSECGKPMRKINHAKGTFWGCTGYPDCQHKEADKKVKSASNKSAKKSSNLNVLDQLNKLRSQL
(49) DNA topoisomerase 3 [Aggregatibacter actinomycetemcomitans D11S-1]
10
MRLFIAEKPSLGRAIADVLPKPHQRGDGFIKCGENDCVTWCVGHLLEQAEPDAYDARFKQWRLEDLPIVPQKWQLIPKKETHKQLKTVEKLVQQADVLVNAGDPDREGQLLVDEVFSYLNLSAEKRNAIQRCLISDLNPSAVEKAIKKLQPNRDFVPLATSALARARADWLYGINMTRAYTIHGRQAGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVLAWVRDPKGEKTPEKPTALFSALWQPSKACEDYQDDDGRVLSRALTENVVKRIADQPAEVTDYTDKREKETAPLPYSLSALQIDAAKRFGMSAQEVLDTCQRLYETYKLITYPRSDCRYLPQEHFADRMAVMNAISSHLSQFQPLPEIIDPEQKNRCWNDKKVEAHHAIIPTAKNRPVGLTSAEQNVYFLIARQYLMQFCPDAEYRKCKITLNIAGGTFVAQARNLQIAGWKQLWGKEDSDDEQQDALLPVVKKGQILHCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTEAGRILINALPDVATQPDMTAHWESQLDGISRKQASYQQFMENLTQLLPELLHYINFSALRELSRHNSGVKKQGIKKKTSRITKS
(825) DNA topoisomerase 1 [Aggregatibacter actinomycetemcomitans D11S-1]
9
MSKSLVIVESPAKAKTINKYLGNNYVVKSSVGHIRDLPTVGSSTGEKAKAISTKGLSAEEKQAIKHKKEQEALVKRMGIDPYHSWKANYQILPGKEKVVAELKSLAKKVDHIYLATDLDREGEAIAWHLREVIGGDDERYSRVVFNEITKNAIKQAFEHPEHLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLIVEREREIKAFVPQEYWEVSVLTNTPKGDEIRLDVVQFKGKKFEPKNAEQAQSAVDFLSKSDYVISDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMVRGYIEKQYGQTYLPAKPNFYSSKENAQEAHEAIRPSDINVGLDDLAGMEKDAVRLYDLIWRQFVACQMPAAQYDSTTLTVTAGDYSLTAKGRILRFDGWTKVLLQQSKSAEDQALPAVSVNDKLNLSEVQPQQYFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFADLMNYDFTANMEDVLDQIASGDKNWKTELNQFFKDFSTQLTKAELDELEGGMRPNNLVETDICCPTCGRNMAIRTASTGVFLGCTGYALPPKARCKTTINLVPEAELLNVLDDASETKALMERKRCPKCGTAMDSYIIDPHRKLHICGNNPNCDGYLVEEGKFKIKGYDGPIVECDKCGGDMHLKLGRFGKYMACTQCDNTRKILKNGEVAPPKEEPIHFPELKCEKSDAYFVLRDGAGGVFMSAHNFPKSRETRAPKVAELALYRERLPEKLSYLADAPQTDPEGSEAIIRFSRKEKRQYVTSEKNGKATKWIVDFVDGKWVERKK
(628) DNA topoisomerase 3 [Mannheimia succiniciproducens MBEL55E]
10
MRLFVAEKPSLARAIADVLPKPHQRGDGFIKCGKNDCVTWCVGHLLEQAEPDAYNPMFKQWRLEHLPIVPKKWRLIPRKEVAKQLKTVENLIHQADQLVNAGDPDREGQLLVDEVFNYANLSTDKRNAIQRCLVSDLNPAAVEKAVKKLQPNTNFIPLATSALARARADWLYGINMTRAYTIRGRQAGYNGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFFEVLAHIQTEDETPQKFTALWQPSKACEDYQDDDGRVLSLGLAENVVKRITGQPAEVTEYTDKREKETAPLPYSLSALQIDAAKRFAMSAQDVLDTCQRLYETHKLITYPRSDCRYLPNEHFAERMPVLNAISTHCKEYQPLPEVLNTEQKNRCWNDKKVEAHHAIIPTAKNRPVNLNSQELNIYTLIARQYLMQFCPDAEYRKSKISLKIAGGNFVAQARNLQIAGWKELLGKEDENEQLEPSLPIVKKGQQLFCEKGEVISKKTQPPKPFTDVTLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSSEAGRILIQALPDMATQPDMTAQWEAQLDGISRKQASYQQFMATLTELLPELVQFVNFSALRKLSAVANNPKPKNFKKKAKIAQSTETKKEV
(87) DNA topoisomerase 1 [Mannheimia succiniciproducens MBEL55E]
9
MSKSLVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTAGASTGEKAKPVSTKGLTAEEKQALKTEKEKNALVKRMGIDPYHGWKANYQILPGKEKVVADLKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDNRFSRVVFNEITKNAIKQAFEKPEHLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPQEYWEVAVVTKTADNQKITLDVAEYKGKRFDPKNETEAQSAVDFLAKSDYIVSALETKPTTSRPRAPFITSTLQQTASTRLNFSVKKTMMLAQRLYEAGYITYMRTDSTNLSRDALNMARSYIERNFGEKYLPEKPNFYSSKENAQEAHEAIRPSDVNISMNDLQGMEKDAVRLYDLIWRQFVACQMPAAQYDSTTLTVKAGDYELKAKGRILRFDGWTKVLPQLGKSAEDQELPALNVHNKLALDEIQPSQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFAHLMSYDFTASMEDMLDQIATGKKDWKTELNQFFKDFSGQLTTAELDELEGGMKPNSLVLTDIQCPTCGRPMAIRTASTGVFLGCSGYALAPKDRCKTTINLIPEAELLNVLDDASETKALMERKRCPKCDTAMDSYIIDPHRKIHICGNNPNCEGYLIEQGTFKIKGYDGPIVECDKCGSDMHLKLGRFGKYMACTACDNTRRILANGEVAPPKEEPIAFPELKCEKADAYFVLRNSAVGVFMSAHNFPRVRESRPAKVAELAQYRERLPEKLQYLADAPQQDPEGNPAIISFSRKEKHQYVTSEKNGKKTKWIVDYIDGNWIERKK
(785) DNA topoisomerase 3 [Oceanimonas sp. GK1]
10
MILYIAEKPSLARAMAEVLPKPQQKGDGFIRLANGDVVSWCIGHLLEQAEPDAYDPAFKQWRREHLPIIPDDWKLVAKPNTKKQLAVLKKLLKEADSIVHAGDPDREGQLLVDEVISYCNVPAAKREAVQRCLISDLNPAAVKKSLATLKPNKDFVPLSVSALARSRADWLYGINMTRLCTLAGRSTGYNGVLSVGRVQTPVLGLVVRRDRDIADFRPKPFYEVLALLQTDSKAQFRAKWQPSEACQPWQDEEGRVLSRALAENVIRRITGQPGRVLAADNKRQRIPPPLPYNLSALQIDAARRFGLSAKQVLDLCQGLYERHKLITYPRSDNRYLPAEHFGQGPAVLAAIAAVCPGLSQAVAAADTGIRGRAWNDARVEAHHAIIPTTRHTDGARLSGTERQIYELIARQYAAQFYPHQELDEKKVELEIAGGRFVARARQQQVAGWKALFTQGKADEEEDDELQAQLPALKTGDTVQCLQGELQEKQTQPPRPFTDATLLSAMTHIARFVTDGELKKILRDTDGLGTEATRAGIIELLFTRGFLERRGRQIHATETGSRLVDSLPASATTPDMTARWEAVLDAISRKQAGYRQFMEELQGQLPMLIDSVKPDAFRGLQGGKPPRKRRGPVRRRARG
(1804) DNA topoisomerase 1 [Oceanimonas sp. GK1]
9
MSKSLVIVESPAKAKTINKYLGRNYVVKSSVGHVRDLPTAGSAGGKKPAARKTDTKQLSPEEKARLKKEKEHKALIARMGVDPEHGWKADYQVLPGKEKVVSELQALAEKADTVYLATDLDREGEAIAWHLKELIGGDDSRFKRVVFNEITKSAIQDAFSQPAELNLNRVNAQQARRFLDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEKEREIKAFVPEEYWDIQAALSNEQQLALSMMVAKYQGKEFRPTNEADAMAAVTALRASSFEVASREDKPTQSKPPAPFITSTLQQAASTRLSFGVKRTMMLAQRLYEAGYITYMRTDSTNLSQEAVASVRDFIEQHHGSAYLPESANVYGAKANAQEAHEAIRPSDVTLSADQLDGMEADAKRLYDLIWRQFVACQMTPAQYDSSTITVRAGDYELKARGRILRFAGWTRVLSPQSRKGEDTELPAVQAGETLSLNELTPKQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVADRLQESFAELMNYDFTAQMESKLDEIAGGKLDWTQVLDAFYAEFSDELEKAEQPAEEGGMRANQMVLTDIDCPACGRKMGIRTATTGVFLGCSGYALPPKERCKQTINLIPGDDFVLANDEEAETDALRAKHRCSKCGTAMDAYLIDDKRKLHVCGQNPDCDGYELEQGQFKLKGYEGPVIDCDRCGAEMQLKSGRFGKYMACTSEACKNTRKILKNGEVAPPKEDPVHLPELPCSQSDAYFVLRDGAAGLFMAASNFPKSRETRAPLVEELVRFKDRLPAKFRYLAEAPTEDPDGNKAVVRFSRKNKEQYVMTEVNKKATGWTAHYVDGKWQQHQKGKK
(186) DNA topoisomerase 1 [Tolumonas auensis DSM 9187]
9
MGKALVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTSGSASTSANKEGVKKATKPSAADKAQKEYSSLVSRMGIDPEHGWKARYEILPGKEKVVAELRALAAQADIIYLATDLDREGEAIAWHLRELIGGDESRFKRVVFNEITKTAIQEAFSHPGLLNIERVNAQQARRFLDRVVGYMVSPLLWKKIARGLSAGRVQSVALRLIVEKERDIKAFVPEEYWDIHADTQTPTRETLRLQVTAQQGKTFDPKNEQQAMAAVQTLKNAAYQVRDREDKPTSSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVVTVREYIEQQFGKKYLPKEPLTYGSKANAQEAHEAIRPSNVEVKADTLKDMEADAVRLYDLIWRQFVACQMTPAQYDTSTLTVTAADFELKAKGRILRFAGWTKALPPMGRKGDDIELPAVNAGDVLQLIKLDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLVESFADLMSYDFTAQMENSLDNIAQGKLDWHKQLDEFYAEFKSDLQKAEGEAGGMRSNQMVLTDIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKQTINLVPGDEYIAADSEDGEVDALLAMHRCKKCGTAMDSYVLDATRKIHICGNNPDCDGYEIETGQFRLKGYEGPVVECDRCGSDMQLKTGRFGKFMACTNAECKNTRKILKNGDVAPPKEDPVFLPELKCSKSDAHFVLRDGAAGLFMAASTFPKSRETRAPLVAELLRFKDRLAPKHQYLAEAPVADPEGNPTIVRFSRKTKEQYVASEVEGKATGWAAYYTNGRWQVSAGKGK
(1681) DNA topoisomerase [Tolumonas auensis DSM 9187]
4
MRLFLCEKPSQGKDIGRLLGARQRGNGCLNGPGVVVTWCIGHLVEAAPPEAYDEQLKRWTIEQLPIIPQHWRVEVKPKTAAQFKVVKDLLSKATELVIATDADREGELIAREIIDLCGYRGPIQRLWLSALNDASIHAALGKLKPSGDTLPMYHSALARSRADWLVGMNLSRLFTLLGRRAGYDGVLSVGRVQTPTLRLVVDRDREIAAFVSVPFWSIEVALSCTGQTFTAQWLPPSASTDDAGRCLQEPVAQQAVQRIRAAGAAQMVSVETERMREGAPLPFDLGTLQEVCSKQFGLDVQETLEIAQSLYETHKATTYPRSDSGYLPESMHAEAPTVLDSLLKTDPSLRPIIDQLDRTQHSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAAYRLIRAHYLAQFLPPHEFDRTTARFSCGDQTLQAVGKHVVVPGWRLVLAEPQPDDAGDDAAPRSQVLPALHQGLACQVAGVDLKALKTLPPRPYTQGELVKAMKSVAKLVSDPRLKQKLKDSVGIGTEATRANIIGGLLNRGYLIKKGRAIRASDAAFTLIDTVPAAIADPGTTAVWEQALDMIETGQLALDTFIDKQAAWVTQLIAQYRGTSLSIKIPEGPACPQCGGATRQRSGKSGPFWSCAKYPDCKGTLPIESGKRAAPRKRRGGPKAS
(163) DNA topoisomerase [Marinobacter adhaerens HP15]
7
MHLYIAEKPSLGRAIAAALPGPHQKGQGWIRCGTGENAATVSWCIGHLLEPAEPARYNPAWKKWRQEDLPMFPDKWEVMPKDSVQQQLKVLESLIRQAKTIIHAGDPDREGQLLVDEVIRYFGASAPVQRILINDLTPAAVARAIQSPRDNREFRRLSHSALARQRADWLYGINLTRFYTLSYQRQGEQGVYSVGRVQTPVLGLVVERDTTIEHFQPKPYYRIEARFRAQEEEADQQTFTARWQPNEQFQDYLDEENRLLNREVAEQIADSVRNRPGTITESRFRDRSEAPPLPFSLSALQIEAGRLFRMGAKDVLDTAQNLYERHQLITYPRSDCRYLPEGHYSQREQVIRAIARVAPDLEEACNGADLGRRTSAWNDKQVDAHHAIIPTSRPTPNGKLSDAEEKIYGLISRYYLMQFAPDAVHREGKLTVRVSEHEFRATETAILVPGWKTLELKLREARKEPEKAPLPRLEKGEPVFCDDSSLSERKTQPPQHFTDATLLSAMTNIARFVTDTELRKTLRETDGLGTEATRAAIIDTLFKRDYLYRDSRHIRATDKAKALISALPESVSKPDRTAVWEANLESIRRGEGDPRKFLDTLKEEIRGFLDRPQGRPTVDSESIGTTSPEAQPHCPKCRAPMLEREGKFGRFFACTRYPDCRGTRPLEEATPQDGTGQKPIPCPHCFSPLVRRKGKKGWFWGCSNFPGCRQTLDDDNGKPSVRLRKST
(1173) DNA topoisomerase 1 [Marinobacter adhaerens HP15]
9
MGKSLVIVESPAKAKTINKYLGSDFIVKSSVGHIRDLPVSGSGSQSDPKERAKQAAITRKMSPEEKAVHKKRKSREQLVARMGVDPDQDWSARYEILPGKEKVVSELKRLAKSADHIYLATDLDREGEAIAWHLQQTIGGEPEKYRRVVFNEITKRAIQEAFKDPGTLDNNRVNAQQARRFLDRVVGYMVSPLLWAKLARGLSAGRVQSVAVRLIVEREREIRKFVPEEFWQLHADLASAKADQPVRFEVTRHEDKPYRPVNEQQSSDHVSRLKAGTFKVAKREDKPTRSRPSAPFITSTLQQAASNRMGFSVKKTMMLAQRLYEAGFITYMRTDSTNLSQDAINSCRAYIEKQFGDKYRPEKPRVYGSKEGAQEAHEAIRPTEVSRRPADISGLEKDAEKLYDLIWRQFIACQMSDAEFLSTSIVVANGDYELRTRGRIIKFDGFLKAAPQAAKKDEDIALPDIKVDEVLDLKKLDPTQHFTKPAPRYTEASLVKELEKQGIGRPSTYASIISTIQDRGYVRLQNRRFYAEKMGEIVTERLSESFPNLMDFDFTARMEDELDEIAEGDVEWKKVLNDFYGRFRQQLEKAESGEDGGMRANTPTETDIPCPSCGRNMQIRVASTGVFLGCSGYSLPPKERCKTTINLVSGDEVVSADDDVEGEGETRLLRKKRRCPKCGTAMDSYLVDETRKLHVCGNNPDCSGYEVEKGTFRIKGYDGPTLECDKCGSEMQLKTGRFGKYFGCTNAECKNTRKLLKNGEPAPPKMDPVPMPELQCQKVDDTYVLRDGASGLFLAASKFPKNRETRPPLVMEIKPHRKEIDPKYDYLMDAPERDPEGNPTVIRYSRKSKEQYVMSEKDGKATGWSAWYVNGKWQPQDKKK
(1049) DNA topoisomerase [Halomonas elongata DSM 2581]
7
MRLIIAEKPSLARAIANALPASPRREEGALVAGDTVVTWCLGHLLEQAPPDAYDPALKTWRLDSLPILPDHWKLMPRPKARGQLAVIRRLLKSADQVVHAGDPDREGQLLVQEVIEHLGWKRDVARLLVSDLNPPAVKRALERLEDNRRYASLYRAAQARARADWLYGINLTRAWTLVGRQAGHDGVLSVGRVQTPVLGLVVRRDAEIRDFEPRPFFVLWVDLVVSRGQLRAWWVPGDTHRLDDQGRLLDRAPAAALADRLPGAEGRLDSLASRDKRQAAPLPYSLSALQVDAARRHGLSAKAVLDVCQRLYERHQLITYPRSDCRYLPEEHFAQAQRTLSGACRNDETLSRWLAGADFSRRSKAWDDKKVGAHHALAPTGKPADLDRLSRQEADVFRLIARNVLAQFYPALQTREVKAEFLIAGERFRARGQEVLEPGWKPLFTTRDEAPPLPPLSEGEACRVEQAGVEDRETRPPEHFTDASLIKAMMNIARYVDDPAIRRTLRDSDGLGTEATRAGIIETLLERGYLVREGKSLKASRLGSALIASLPEAVGRPERTAQWEQRLANIAEQDDAPAPFLEGLIDDLRGLLGHADAGRVRSALSEARGPEPKASKPARGRGRSTKRGSGQRRQGKGTRRAAGGKRQ
(346) DNA topoisomerase 1 [Halomonas elongata DSM 2581]
9
MGKSLVIVESPAKAKTINKYLGNEYIVKSSVGHIRDLPTSGSGKAASDPKERARQAAATRKMSAEEKAEYRKRKAHDQLIRRMGIDPDHGWEAEYVVLPGKEKVVAELKKLADKADNVYLATDLDREGEAIAWHLRETIGGDESRYRRVVFNEITKNAIQEAFEDPGQLNMPRVEAQQARRFLDRVVGFMLSPLLWAKIARGLSAGRVQSVAMRLIVEREREIRAFVPEEFWDVHADLSPRDGNGETVRFELARQDGKTFRPTSETETLERIAALREANLVITSREDKPTRSRPNAPFITSTLQQAASGRLGFSVKKTMTLAQRLYEAGYITYMRTDSTNLSQEAVAGARDYIGEAYGKPYLPETPNRYTSKEGAQEAHEAIRPSDVTRRAGDLAGMERDAERLYELIWRQFVACQMTPAEYLSTTLTVEASGYELRAKGRVLKFDGYTRVMAPMGRKDEDQSLPDLAEGTALTLEALDPQQHFTKPPARYTEASLVKELEKKGIGRPSTYASIISTIQDRGYVRLENRRFYAEKLGDIVTERLKESFPDLMDYSFTARMEDSLDEVAEGQRRWRELLDAFYAEFREELKVAESEEGMRPNQPVPTDIECPTCGREMQIRTASTGVFLGCSGYNLPPKERCKTTMDLLPGDEAVAADAGEEAETDALRAKHRCPKCGTAMDSYLIDEQRKLHICGNSPDCDGHEVEEGRFRIKGYDGPTIECDKCGSEMQLKSGRFGKYFGCTNDTCKNTRKLLRNGEVAPPKMDPIPMPELACQKVEDHYVLRDGASGLFLAASKFPKNRETRPPLVVELQAHADELPEKYRYLLDAPSADPDGRPAQIRFSRKTKEQFVMTDDNGKATGWKATFADGRWQVEDKRK
(704) DNA topoisomerase [Halomonas elongata DSM 2581]
4
MSRLFLCEKPTQARDIAKVLGASEKGNGCLKGRGITVTWGFGHLLEQANPEAYDPALKRWSMESLPILPTQWKLEVKPSAKKQFTVVKKLLSSASEVVIATDADREGEMIAREILEACQFSGGVSRLWLPALDEASIRKALGDIRPGESTRLLYHAALGRSRADWLVGMNLTRAFTMRAKQLGYDLLLSVGRVQTPVLKLVVDRDREIANFVPKPFWEVVAVFQAEGGTFQAKWQPADDDVLDESGRCINQSAAQAVVARCQGLPGQVTTLETTRKREAPPLAMDLGTLQQTCSKRWGYGAQQVLDIAQALYETHKATTYPRTDCRYLPLSQLDDAQQVVTALLTSDGELAPVVQSLDLTRKSRVWNDSKITAHHGIIPTTSPCDTSKMSEAEWNVYDLVRRHYLAQFLPPHEYDHTDVALEVAGERFATTGRQVQVEGWKVLFRNVQQDDAAGDEATAKTSSQALPPLQAHANVPQSSLDLVSKTTTPPKPFAEGTLIGAMKNAARFEPNPKLKARLKESAGIGTEATRAGIIETLLKRKFLTKKGRAIVATATGRQLIDALPEVVTNPGMTALWEQALDSVAAGELSLEDFMAKQQTLVERLIEQAKSATINLPQEPAKSKACPECGAPMKKRKNDYGSFWGCTKYPDCKGMVKIGSGKKRQGKGRKASNG
(1318) DNA topoisomerase 1 [Xanthomonas oryzae pv. oryzae KACC 10331]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNSFAMRYDLIEKNEKHVEAIARAAKGADDIFLATDPDREGEAISWHIAEILKERGLLKDKPMQRVVFTEITPRAIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIDAHCRHPSQAFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALSEIRDVIARDYGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVPGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTAKLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGTDPVSGKEVSARIGRFGPMVQIGSVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKDFEGSDIQVLNGRFGPYISDGKLNGKIPRDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVKDSAPKKPAAKKTATKTAASKTAAKKAPAKKAAAEKGTKRVVKKTVSKAAD
(31) DNA topoisomerase 1 [Xanthomonas campestris pv. campestris str. ATCC 33913]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNGFAMRYDLIEKNEKHVEAIARAAKSADDIYLATDPDREGEAISWHIAEILKERGLLKDKTMQRVVFTEITPRAIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIDAHCRHPSQPFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALAEIRDVIARDFGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVAGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTANLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGADPVSGKEVSARIGRFGPMVQIGTVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKEFDGSDIQVLNGRFGPYISDGKLNGKIPKDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVKDSAKEAKDAAKKTAAVKKVATKTAAKKAPAKKAAKKATKRVVKKAVSKAAG
(1596) DNA topoisomerase 1 [Methylomicrobium alcaliphilum 20Z]
1
MSNNLVIVESPAKAKTIEKYLGKDFHVLASYGHVRDLVPKEGAVDPEHDFAMKYEIIERNQRHVQAITKAIKQAQALYLATDPDREGEAISWHLYELLKDKKLLKDKPVHRVVFHEITKKAVTEAIAHPAELSIDLINAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSREYWTIDAELSAEEQAFKAKLTHFEGEKVEQFTIDNEERALQVKQTLFDAADGKLLVAKVEKKQRKRNPAPPFITSTLQQEAARKLGFTTKRTMMVAQQLYEGIDIGGETVGLITYMRTDSVNLAAEAIAEIRELIAEKYGAKNVPKSPRDYKTKSKNAQEAHEAIRPTSARRIPVELQKFLSPEQFKLYDLIWKRTISSQMVHATINTVAVDLHCGSERNVFRATGSTIADPGFMAVYLEGKDDTAEGDDKENFLPSLEEGRPVPLNDIIAGQHFTEPPPRYSEASLVKALEEFGIGRPSTYASIISTLQNRDYVTLESKRFYPTDVGRIVNKFLTEHFNKYVDYDFTANLEDELDAVSRGEKDWIPLMRSFWEPFNTLIHEKEESVQRKDVTQEAIDEKCPECGSPLSIRLGRNGRFIGCTNYPECSYTRNLNEDASKSSEPEVVEGRVCPKCESPLVIKTGRYGKFIGCSSYPKCKHIEPLEKPVDTGVECPQCKKGNLLKRKSRNGKIFYSCSEYPKCSYAIWNAPVQENCPECNWPILTLKTTKRRGTEKVCPQKECSYATPYEGDPDDVLGPKG
(20) DNA topoisomerase 1 [Pseudovibrio sp. FO-BEG1]
1
MESPAKAKTINKYLGKDYTVLASYGHVRDLPPKDGSVLPDDDFAMSWSVDSKSQKRLSDIASAVKEADRLILATDPDREGEAISWHVLEVLKKKRVLKDKKVERVVFNAITKSSILEAMKNPRELDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCQRENEIETFLSQEYWSILANLNTPENAPVQARLTGFDGQKITRLDIKNEQEATTIKQMLDGANFSVSNVESKPQRRNPYAPFTTSTLQQEASRKLGFAAARTMQVAQKLYEGANIGGETTGLITYMRTDGVQIAPEAITSARGVIASRYGDEYVPEKPRMYSSKAKNAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIWKRTIASQMESAVLERTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESKRLPPMTRGDSLGRKGIEANQHFTEPPPRFTEATLVKKMEELGIGRPSTYAATLQTLRDRGYVELDKKRLIPQDKGRLVTAFLEDFFNRYVEYDFTASLEDQLDKISAGDLEWKAVLRDFWNPFHEICDEVIKRSNTEVLDALNETLKAHVFPDKEDGSDPRKCPKCDTGRLSLKVSRFGAFVGCSNYNKDKKDGKEPNENPPHCDYTRQLTSGGDSDAGAAADGPQVLGIDPETGLEVSLRTGRFGPYVQLGEEAKPKRSSLPRGWSTADLDLEKALQLLSLPREVGTHPEDGKTISAGLGRFGPFVLHDGTYANLDSPDEVFSVGINRAVTLLAEKRAKGGGRGAAAKPLKELGNHPDGGAINVYSGRYGPYVKWEKINATLPKDVAPEAVTLEQAIELVNAKAATKGKKKAPAKKAAAKKTTAKKAAPKGALKEFGDHPDGGAMELRDSGRLGVRIKWGKEFVSLPKGTDPETVTREQAIELINAKKG
(1747) DNA topoisomerase 1 [Candidatus Liberibacter asiaticus str. psy62]
1
MNVIIVESPAKAKTISKYLGSNYKVLSSFGHIRDLPAKKGSVLPEKEFEMIWNIDPSSQKHLQNIIHAVKSSTILILATDPDREGEAISWHVLDVLRQKNLIEKTKIQRVSFNAITKQVVLNAMKSPRDINLDLVNAYLARRALDYLVGFNLSPILWQKLPGARSAGRVQSVALRLICNRENQIESFVSEEYWSLSVLLETPRNDKFTAHLTDFNGQRIEKKSISNKKEADDLISFVKKATYSVEKIENKPIKRNPWPAFTTSTLQQVASSRLGFSASHTMRIAQKLYEGIDVNGEIVGLITYMRTDGVHMSPDALEAVRRSITSHYGDHYLPEKPRIYSSKSKNAQEAHEAIRPNDFDFLPSKMKQFLDSDQFQLYNLIWKRSVASQMASAKFERTTVNIIATYNDQIGHLRTTGSLLCFDGFLKVWENQYDQEKNSEEDILLPYISANEQLIATETNASQHFTEPPPRYSESSLIKKMEEIGIGRPSTYATILETLYKRKYVIAEKRKILPQNTGRIVTAFLENFFSQYVEYDFTADLEEKLDEISTGKLNWKEVLHEFWEEFIEKIDSIKKLRISNVLDILNDTLSSVIFPPKENNEDSRTCPECHTHSLSLKLSSKYGAFVGCTNYPECKYTRQLTSNPQDIPEMKESVLLGNDLETKESVTLRSGRFGLYVQRGDGKDAKRCSLPKTWKSDSVDYDKAMSLLSLPREIGIHPETQKNIIAGTGKYGYYLNHDGAYTKLESIEQVLTIDLEQAISCITEKKKIEKSSRKNSKNQGHVIGTHPEGGSITVHNGRYGPYLHWKKINASLSKEESPDTVDLEKALKILNIKKQKKL
(1624) DNA topoisomerase 1 [Agrobacterium sp. H13-3]
1
MLTDQFQRKNNMNVVVVESPAKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVLPDQDFEMSWEVDSASAKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLKKKRVLGDKPVKRVVFNAITKKAVLDAMANPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVSLRLVCDREAEIERFVSEEYWNISALLKTPRGDEFEAKLVSADGKKLQGRSIKTGDDANRLKALLEGATYIVDTVEAKPVKRNPGPPFTTSTLQQAASSRMGFSASRTMQVAQKLYEGIDIGGETVGLITYMRTDGVQMAPEAIDAARRAIGEQFGDRYVPEKARFYSTKAKNAQEAHEAIRPTDFNRTPDQVKRYLDADQLRLYDLIWKRGIASQMASAEIERTTVEILADKDGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDDEGRLPQINARENLAKQKINASQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLKTLSDREYIIIDKRKLIPHSRGRLVTAFLESFFAKYVEYDFTADLEEKLDRISAGELDWKQVLRDFWKDFFAQIEDTKELRVTNVLDALNEVLAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNFTRQLTSDGSEAEASVSNEPKALGADPMTGEELTLRSGRFGPYIQRGDGKEAKRSSLPKGWKPEEIDHEKALALINLPRDIGKHPETGKMISAGLGRYGPFLLHDGSYANLESIEDVFSIGLNRAVTVIAEKQSKGPGRGRNGTPAALKELGDHPDGGPITVRDGRYGAYVNWGKVNATIPKGQDPTSVTLDESLVLIAERIAKTGTGGKPAKAKKPAAKKADGDTAAKPKATKAKAATKSKTAAKPKAAAKPKKAES
(1515) DNA topoisomerase 1 [Agrobacterium fabrum str. C58]
1
MNVVVVESPAKAKTINKYLGSGYKVLASFGHVRDLPAKDGSVLPDQDFEMSWEVDSASAKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLKKKRVLGDKPVKRVVFNAITKKAVLDAMANPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFVSEEYWNISALLKTPRGDEFEAKLVSADGKRLQSRGIKTGEDANRLKALLEGATYVVDTVEAKPVKRNPGPPFTTSTLQQAASSRMGFGASRTMQVAQKLYEGIDIGGETVGLITYMRTDGVQIAPEAIDAARLAIGEQFGERYVPEKARFYSTKAKNAQEAHEAIRPTDFTRTPDQVKRYLDADQLRLYDLIWKRGIASQMASAEIERTTVEILADKNGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDDEGRLPQINARENLAKQKINASQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLKTLSDREYIVIDKRKLIPHSRGRLVTAFLESFFTKYVEYDFTAALEEKLDRISAGELDWKQVLRDFWKDFFAQIEDTKELRVTNVLDALNEVLAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNYTRQLTSDGAEADAAASNEPKALGADPMTGEELTLRSGRFGPYIQRGDGKEAKRSSLPKGWKPEDIDHEKALALINLPRDIGKHPETGKMISAGLGRYGPFLLHDGSYANLESIEDVFSIGLNRAVTVIAEKQAKGPGRSGTPAALKELGDHPDGGAITVRDGRYGAYVNWGKVNATIPKGQDPASVTLDESLVLIAERIAKTGTGGKPAKAKKTTAKKADGEAAAKPKATKAKAATKSKAAAKPKAAAKTKKAAE
(1503) DNA topoisomerase 1 [Agrobacterium vitis S4]
1
MNVVVVESPAKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVLPDQDFEMLWEVDTASAKRMKDIADAMKGADALFLATDPDREGEAISWHVLDLLKKKKVIGDKPVKRVVFNAITKKAVLDAMAAPRDIDGDLVDAYLARRAMDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRENEIERFVSEEYWNLSALLKTPRGDEFLARLVSADGKRLQARSVGNGDMANRLKDLLDGANYVVESIEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIEAARSAITQQFGPRYMPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDQVRRYLDADQLRLYDLVWKRGIASQMASAEIERTTAEILADKAGEKAGLRAVGSVIRFDGFIAAYTDHREEGEKSDDDDEDGRLPEINAREALAKQKVNATQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATLKTLSDREYVVIDKRKLIPEAKGRLVTAFLESFFTRYVEYDFTADLEEKLDKISAGELNWKDVLREFWQNFFAQIEGTKELRVTNVLDALNEALAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNFTRQLSADGGTEAEAVGNEPKALGEDPTTGEQITLRSGRFGPYVQRGDGKEAKRSSLPKGWSPTDVDFDKALSLLSLPREVGLHPETGKMMTAGLGRYGPFVLHDGTYANLDGIEDVLTIGLNRAVTVLAEKQANPGGRGRAAPAALKEIGDHPDGGAITVRDGRYGPYVNWGKINATIPKGMDPQAVTMEEAIALIVERAAKEGSGKTKAKPAAKSASAKKAPAKKPAAKATKADADDAADAKPKKAAAKPKATKPKAKPAAKTEKA
(994) DNA topoisomerase 1 [Sinorhizobium fredii HH103]
1
MTMNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLKKKKVIGDKPVKRVVFNAITKKAVLDAMADPRDIDISLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNIVALLKTPRGDEFEARLVSADGKRLQPKSIGNGEDANRLKALLDGASYVVESVEAKPVKRNPGPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDVGGETVGLITYMRTDGVQMAPEAIDAARRAIGSQFGPRYLPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDQVRRVLDGDMLKLYDLIWKRGIASQMASAEIERTTAEIAADNGGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDEDGRLPEINARENLAKQKINATQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATISTLVDRDYVEIDKRKLMPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLREFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRTCQVCGTGKLSLKLGKYGAFVGCSNYPDCNYTRQLSSDSNGDAEAAVSNEPQSLGKDPHTGEEITLRSGRFGPYVQRGDGKDAKRASLPKGWTPATIDHEKAIALLSLPRDIGKHPETGKMISTGIGRYGPFVLHDGTYANLESVEDVFSIGLNRAVSALADKQSKGAGGARGRTAAAALKELGEHPDGGAMTVRDGRFGPYVNWGKVNATLPKGKDPQSVTVEEALALIAERAAKGGVSKGKSAKGRSAATKSTAAKAEKPKAAAKAKSKTAAKAKKG
(389) DNA topoisomerase 1 [Sinorhizobium meliloti AK83]
1
MNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLILATDPDREGEAISWHVLDLLRKKKVIGDKPVKRVVFNAITKKAVLDAMAEPRDIDASLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLPPKAIGNGEEANRLKSLLDGASYVVESVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIEAARQAIGSQFGERYLPEKPRFYSTKAKNAQEAHEAIRPTDFDRTPDQVRRFLDGDMLRLYDLVWKRGIASQMASAEIERTTAEIVADNAGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDEDGRLPEINARENLAKQKINASQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATVTTLIDRDYVEIDKRKLVPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLRDFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRICQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSNGDAEAAAANEPQSLGKDPHTGEEITLRNGRFGPYVQRGDGKEAKRASLPKGWTPAAIDHEKALALLSLPRDIGPHPESGKMISTGIGRYGPFVLHNGTYANLESVEDVFSIGLNRAISVLADKQSKGAGGGRASAAALKELGEHPDGGAITVRDGRFGPYVNWGKVNATLPRGKDPQSVTVEEALALIAEREAKGGVTKGKAAKGKPTGGKSAGTKSAKAASAGTAKAEKPKSAAKTKTKAAAKAKKD
(330) DNA topoisomerase 1 [Paracoccus denitrificans PD1222]
1
MPVVVVESPAKAKTINKYLGDDYTVLASFGHVRDLPPKDGSVDPEADFAMKWEVASESKKHVKAIRDALAADPNLILATDPDREGEAISWHLLETLAPALKKGAEVSRVTFNAITKAAVTEAMANPRQIDQPLVDAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVALRVIVDREMEIEAFKAREYWSVHARLATPRGDEYDATMTVFGGKKLERFDIASEEQAKLAVAAITSRDLRVASVAAKPASRNPWPPFMTSTLQQEASRKLGLGARACMSAAQRLYEAGHITYMRTDGIDMAPEAVMAARDAIKARFGAEYLPKSPRMYKNKAKNAQEAHECIRPTDMMLSPDRLPVSDKDQKALYDLIWKRTIASQMESARMERTTVEIGSADGQVGLRANGQVMLFDGFLRVYDQGRDDEEDEDSRRLPSIEEGERAEKRSVTPEQHFTQAPPRYTEATLVKRMEELGIGRPSTYASIVTTIQDRDYVRKEQNRLIPEDKGRLVTIFLLKYFPRYVSYDFTANLEGELDDISSGERAYREVLRRFWRDFTAALEGTSELRITEVLDAIDEALAPHLYPPRADGSDPRECPLCHKGRLHLKTARSGGAFIGCSNYPDCRFTRPISSPDAEVVGDAVLGVDNGDEISLKNGRFGPYVQRGEATAENPKPPRASIPKGWDLASVDLERALALLSLPREIGSHPEDGVPVEAGIGRYGPYVKHGAKYANLPDVDEVFTIGMNRAVEVLASKQVRGRAAVAAPLAELGEHPEGGSVQVMSGRYGPYVKWGKVNATLPRDLEPGAVTLERALELIAEKAAKSGKKPAKKAAAKKPAAKKPAAKKPAAAKAKKAG
(1266) DNA topoisomerase 1 [Rickettsia heilongjiangensis 054]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKAIIHAVENPRKLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTEKLKSQKFHVDKIEKKQQKRQPQPPFITASLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDKAEEENKMLPPLKEQEPLKTKKVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKPA
(1207) DNA topoisomerase 1 [Rickettsia peacockii str. Rustic]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKTGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTQVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAVRKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGTLEWKAALNNFWSGFNHNIESVNEQNITEIISYVQKALDYHLFGENKESKICPSCHTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(623) DNA topoisomerase 1 [Sinorhizobium medicae WSM419]
1
MSWRRYWRAWSPKQLFQRMSMNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKASDGLILATDPDREGEAISWHVLDLLRKKKVLGDKPVKRVVFNAITKKAVLDAMAQPRDIDASLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLPAKAIGNGEEANRLKTLLDGASYVVESVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGIDIGGETVGLITYMRTDGVQMAPEAIDAARQAIGSQFGERYLPEKPRFYSTKAKNAQEAHEAIRPTDFNRTPDQVRRFLDGDMLRLYDLVWKRGIASQMASAEIERTTAEIVADNAGKRAGLRATGSVIRFDGFIAAYTDMKEDGEQTDDGDEDGRLPEINARENLAKQKINASQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATVTTLIDRDYVEIDKRKLLPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDRISAGELNWKDVLRDFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRICQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSSGDAEAAASNEPQSLGKDPHTGEEITLRNGRFGPYVQRGDGKEAKRASLPKGWTPATIDHEKALALLSLPRDLGPHPETGKMISAGIGRYGPFVLHNGTYANLESVEDVFSIGLNRATSVLADKQSKGAGGAGGRTGAAAVKELGEHPDGGAITVRDGRYGPYVNWGKVNATLPRGKDPQSVTVEEALAFIAERAAKGGVTKGKTAKGKSAGRKQAGTKTAKAAGTATAEKPKRAAKTKTKSAAKAKKD
(659) DNA topoisomerase 1 [Roseobacter denitrificans OCh 114]
1
MPVVVVESPAKAKTINAYLGDDYTVLASYGHVRDLPPKDGSVNPDADFEMLWEVGYDSRKHVKAIADALKEDNALILATDPDREGEAISWHLQEALTKRKSIKKDTPVSRVVFNAITKAAVTEAMQNPRQVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVTLRLIVEREMEIEAFRAREYWSVKALLATPRGQEFEAKLTVLAGKKLDRFDIENQTQAELAVQAITSRDLSVKSVEAKPANRNPSAPFMTSTLQQEASRKFGMGARQTMSTAQRLYEAGYITYMRTDGIDMAPEAVTAARDAIKTLYGSKYVPEKPRIYKNKAKNAQEAHECVRPTDMMTKAEDLKTTDADQRKLYDLIWKRTLACQMEAARMERTTAEIASEDGQVGLRATGQVMLFDGFLRVYEEGRDDVAVVDDDDKRLPQIDQGDRLDKRTVTPEQHFTQPPPRYTEATLVKRMEELGIGRPSTYASVVTTIQDREYVRKDKNRLIPEDKGRLVTAFLSNYFRKYIGYDFTADLEDQLDTVSAGNADYKEVLGRFWRDFSAAIAETADLRITEVLEKINEVLEPHLFPPNEDGSDPRLCPNCGAGRLSMRTARSGGAFIGCSNYPECRYTRAFGPPGEEDDSGIPPEGKLLGEDGDDKIYAFKGRFGPYVQRGEVTEDNKKPPRQSIPKDWPPEDVDLPQALKLLSLPREIGPHPEDGIMVWANIGRYGPYLKHAPSTSDRGGTNANLESIEEVFTVGMNRAVQLLAEKVASRGRRGGAAKTLRDLGEHPEEGGPVAIMEGKYGPYVKWDKINATLPKDSDPAELTMEAAIALIDEKAASKGKKRRKAAPKKAAAKKTATKKAAPKKTAAKKKAPAKKAKE
(1205) DNA topoisomerase 1 [Ochrobactrum anthropi ATCC 49188]
1
MNVVVVESPAKAKTINKYLGSNYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSSKRLADIVKALKDSDGIILATDPDREGEAISWHVLEVLNQKKALKGKTVKRVAFNAITKKAVLDAIANPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVADRESEIERFIREEYWNIAALLKTPRNDGFTARLTAVDGKKLGKLDIKNGEQATAIRTMLEGASFKALSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIGKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRYLDDDQARLYELIWKRAIASQMQAADIERTTVDIEAVNSSRSAMLRANGSVTKFDGFLAAYMDHREEEDDDEDSAKLPEIRSGEALAREKIDATQHSTEPPPRYSEASLIKKMEELGIGRPSTYAATLATLRDREYITIDKRKLIPEPKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKDVLRDFWRDFSGNVDDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGMLSLKLGKYGAFVGCSNYPECKYTRQLGGDANGESAAADEPKSLGKDPFTGEEITARTGRFGPYVQRGEGKEAKRASLPKGWTVDTLDHEKAVALLSLPRDIGQHPETGKMISAGIGRYGPYVSHDGTFANLENAEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGSITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKSKKTPARKASASTEKKAAAKKPAAKKAPAKAKSTAKPKAKSKAETVEE
(1623) DNA topoisomerase 1 [Rhodopseudomonas palustris CGA009]
1
MNLVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDADFQMIWEVDPKAASRLNDIAKALKGADKLILATDPDREGEAISWHVLEVMKQKRALKDQQVERVVFNAITKQSVTDAMKHPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRETEIEKFVPREYWSLIATMATPRGETFEARLVGADGKKIQRLDIGTGAEAEDFKKAIEAANFRVATVEAKPARRNPYAPFTTSTLQQEASRKLGFAPAHTMRVAQRLYEGVDIGGETVGLITYMRTDGVQIDSSAITQARKVIAEDFGNAYVPDAPRQYTAKAKNAQEAHEAIRPTDLSRRPSDVSRNLDSDQARLYELIWIRTVASQMESAELERTTVDIEAKAGSRVLELRATGQVVKFDGFLAAYQEGRDDDSEDEDSRRLPAMSENEALKREALAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVRLEKKRLHGEDKGRVVVAFLESFFTRYVEYDFTAGLEEDLDRISNNEVSWKQVLSDFWRDFIGAVDEIKDLRVAQVLDVLDEMLGPHIYPAREDGGDPRQCPSCGTGKLNLKAGKFGAFVGCSNYPECRYTRPLASDSAGDADRVLGTDPDSGLEVAVKSGRFGPYIQLGEAKDYAEGEKPKRAGIPKGTSPSDVDLEMALKLLALPREVGKHPETGQPIKAGIGRFGPYVQHEKTYASLEAGDDVHTIGLNRAVTLIAEKVAKGPSKGRFGSDPGKALGDHPSLGAVAVKKGRYGAYVTAGGVNATIPNDKTEDTITLPEAIALLDERAAKGGGKAKKAPAKKAAAKKASADGEAKPVKKAAAKKAKPKAEGAAASKARAPVAAKTAAKKAAKPKDAAKSSAAKNG
(1366) DNA topoisomerase 1 [Oligotropha carboxidovorans OM4]
1
MNLVIVESPAKAKTINKYLGSSYEVLASYGHVRDLPAKNGSVDPDANFQMIWETDPKAASRLNDIAKALKGADKLILATDPDREGEAISWHVLEVMKQKRALKDQKVERVVFNAITKQSVTEAMNNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREIEIEKFVAREYWSLVATLATPRNDTFEARLVGADGKKIQRLDIGTGAEAEDFKKALETAAFTVSLVEAKPARRNPQAPFTTSTLQQEASRKLGFAPSHTMRIAQRLYEGIDIGGETTGLITYMRTDGVSIAPEAIPALRKVIAEEYGSNYVPSAPRQYTSKAKNAQEAHEAIRPTDVSRRPAKLKARLDNDQYRLYELIWMRAIASQMESAELERTTVDITAKAGARTLELRASGQVVKFDGFLAVYQEGRDDDPEDEESRRLPAMSEGEALKRESLAVTQHFTEPPPRYSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLSAEDKGRVVVAFLQKFFARYVEFDFTADLEEQLDKISNNEVAWKNVLSDFWRDFIGAVDEIKDVKVSEVLDVLDAMLGEHIYEPRADGGDPRQCPSCGTGRLNLKAGKFGAFVGCSNYPECRYTRPLAASSGTSDRVLGKDPKTNLDVAVKAGRFGPYIQLGEPNDYAEGEKPKRAGIPKNMSPADVELDLAIKLLSLPRDVGPHPEDGEIITAGIGRFGPFVRHGKTYASLEAGDDVYTIGLNRAVTLIAEKIAKGPSRRFGADPGKEVGDYPARGGKIMLKKGRYGAYVTIDGINATIPDDKEPDQITLEEAIALIEARAAKGGKAKRAPKKAAAKKAAPKKKATAKKKADSEPESGAKPAKKAATRTAPKARTSTAKPAAKTAAKAKPTAKKSAGKARG
(184) DNA topoisomerase 1 [Hyphomicrobium sp. MC1]
1
MNVVIVESAAKAKTINKYLGSGYKVIASYGHVRDLPAKDGSVEPDHDFNMHWEVDTKSQKIMREIAEAVKKADKLILATDPDREGEAISWHILQILNQKKALGKDTEVERVAFNAITKQSILAALKEPRKIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVCDREAEIEAFKTEEYWTIEALLSTAKNEDVRSRLVAIDGTALKKLDIKDEATATAIRKALLGQDFRIASVEKKATKRNPFPPFTTSTLQMDASRKLGFSAKQTMQIAQRLYEGVDIGGETVGLITYMRTDGVQIVPEAVSQIRDVISAEYGKNYTPFAREYKTKAKNAQEAHEAIRPTDPRRKPDQVRKHLEKDQAALYDLIWKRTIASQMAAADIEQTTAEIDVKGSDGKAYGLRANGSVLMFDGFLKVYEEGRDDRVRTIEKGKDDTADEDDDSRRLPPLAVGDRLKDKEISADQHFTQPPPRFSEATLVKRMEELGIGRPSTYASTMAVLVDRDYVRIEKKRLIPEDKGRLVIAFLESFFKRYVEYDFTADLEEKLDLISNDELEYKQVLRDFWRDFMAAVGEIKDLRVGDVLEALNEMLGPHVFPDKGDGSDPRLCPKCGTGRLSLKISGKYGAFIGCGNYPECNYTRQLTQSSDGDAAALDGKILGYNDDGLAVTMKTGRFGPYIQLGEAEGDEKPKRSSIPRGIDAATLDFERAMQLLSLPRDVGEHPDEGGMITAGLGRFGPFIVHEKDGAKTYVNLESLEDVFTVGLNRAVTLIAEKRAGGGKSRFQRNAPKVVKDLGQHPSEGGAVQVLEGRYGPYVTHNKVNATVPKAKNPAELTMDEAVALINERTANGGGKKGKPARGAKAKAAKDDKPAKAPKADKAAAPKAAKKPAATKTAAAKAEKAPAKKAPATSAGAKKLARAKA
(396) DNA topoisomerase 1 [Hyphomicrobium denitrificans ATCC 51888]
1
MNVVIVESAAKAKTINKYLGSGYKVIASYGHVRDLPAKDGSVEPDHDFAMQWEVDSKSQKIMREIADALKNADKLILATDPDREGEAISWHILEILNNKKALKKGTEVERVAFNAITKQSILAALKEPRKIDEPLVEAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIEAFKTDEYWTIEALLTTSRGDDVKTRLVAIEGTALKKLDIKDEASATAIKAALEGRDFRVASIEKKAAKRNPYPPFTTSTLQMDASRKLGFSAKQTMQIAQRLYEGVDIGGETVGLITYMRTDGVQIVPEAVSQIRDVISAEYGKQYTPFAREYKTKAKNAQEAHEAIRPTDPRRKPDQVRKYLEKDQAALYDLIWKRAIASQMAPADMEQTAVEIEAKGSDGKNYGLRANGSVLLFDGFLKVYEEGRDDRFRYIEKGKDDPEGEDEDRRLPALAEGDHLKDKEISADQHFTQPPPRFSEATLVKRMEELGIGRPSTYASTMAVLVDRDYVRIEKKRLVPEDKGRLVIAFLESFFKRYVEYDFTAELEEKLDLISNNELAYKEVLRDFWRQFIASVGEIKDLRVGDVLEALNEMLGPHVFPDKGDGSDPRLCPKCNQGRLSLKISGKYGAFIGCGNYPECNYTRQLSQSANNGEAALDGKVLGYNDDGIAVALRTGRFGPYIQLGEATGDEKPKRSSIPKGIDAATLDFEKAMQLLSLPRDVGVHPTEGGMITASLGRFGPFILHEHDGAKTYVNLGNVEDVFTIGINHAVTLLAEKRAGGGKSRFQRNAPKVLKDLGAHPSEGGPVQVLEGRYGPYVTHNKVNATVPRGKDPSALTMDEAVALIAERIANGGGKKSKASRSSAKPKAAKAAKPAKGEAAPAAKRTAKPAAAKKAAPAKKSAAKPAAKKLAKAKA
(1146) DNA topoisomerase 1 [Rhodomicrobium vannielii ATCC 17100]
1
MNIVIVESAAKAKTINKYLGADYKVIASYGHVRDLPAKDGSVLPDNDFEMTWEVEADSNRIVNEIAKAVKGADRLILATDPDREGEAISWHLLKILEQKRALNGVSVERVAFNAVTKDAILTAMKNPRKIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVVDREAEIEAFRTREYWTVEAALKNGGGDAFTARLVARAGKKLDKFDIPNEALAHAYRDAIKGQSYRVDSVDAKDHKRNPAPPFTTSSLQQEASRKLGLSPRQTMQIAQKLYEGIDIGGETVGLITYMRTDGVQIVGEAIAQARGQIESQFGARYVPSAPRIYKTKAKNAQEAHEAIRPTDFGRQPDKLRGLSAEEARLYKLIWQRAVASQMASADIERTTAEISVPGKDGVPYGVRATGSVVKFDGFMRLYEEGRDDTDDEDSARLPPLKQGEALKDSGVTAAQHFTEPPPRYTEATLIREMERLGIGRPSTYASTMAVLREREYVKLEKKRLVPEDKGRLVTTFLEAFFKRYVEYDFTAYLEDRLDQISDGKLDWKALLREFWQDFIGAVTDIKDLRVTQVLDALNELLGPHIFPAKEDGGDPRLCPLCNQGQLSLKIGKFGAFVGCSNYPECRYTRQLKTGENGNGDGAAPAGDTVLGNDPETGLAVCLKNGRFGPYIQLGEGGDGEKPKRASIPGGMGLADVDFAYALKLLALPREVGPHPETQKTIMAGFGRYGPYVEHDGKYVKIDAEEVFTIGLNRAVTVIAEGGTGGKGRAPKTEPIKVLGEHPEKGGKMEVLAGRFGPYIKWGKVNATIPKGTEPQDVTVDEAVRLIAARIEAGDGKKGRGKPTKSAKAPAKEKKPAKAKTADAGDEAEAPKKAKTAAPKKAAANGKAKSSAKEKSAKADEADKKPKAKASAKKTTSKAAGGTT
(1538) DNA topoisomerase 1 [Pelagibacterium halotolerans B2]
1
MKVVIVESPAKAKTINKYLGKDFEVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDTNSKKRLADITRALKGADELILATDPDREGEAISWHLLDALKAKKAIKADMPVKRVVFNAITKDAVTTAMQHPRDIDAPLVDAYLARRALDYLVGFTLSPILWRKLPGSRSAGRVQSVALRLVTEREEEIERFKPQEYWSVIPTLNQTGKSFATRLYSVDGDKTDKLAIKTGEDAQGLKTAIEKGNFKVASVDRKPTKRNPYAPFTTSTLQQDASSRLSLSPSRTMQIAQRLYEDGLITYMRTDAVQMAPEAIEAARRVIGKEFGSEYVPEKPRFYSTKAKNAQEAHEAIRPTDLGKHPDTLRNLDPDQHKIYQLIWRRALASQMRSAEIERTTADIDVLAAGRAITLRATGSVVTFPGFLGVYGVEKTDEDDEDGKDLPALNVGDTPALENVAIEQHFTQPPARYTEASLIKKMEELGIGRPSTYAATLKTLQDRDYIKLEKRAIMPEDRGRLVTAFLQSFFTKYVEYGFTAGLEEELDEISAGEIDYKEVLRRFWKDFSHQADEIKDLRVSEVLDALNDLLGHHIFPERPDGTDPRLCPTCGTGQLSLKLGKYGAFIGCSNYPECRHTQQLAESATGQASEAAQGDGVLGADPETGAEIYLKTGRFGPYVQLGEDAKDAKRSSIPKGWDAGSMDLEKALKLLSLPREVGLHPEDGKPISAGIGRYGPFVLHEKTYANLPDVEEVFTVGLNRAVDLIAQKRAGGGRGGRGAAVAAIQTFEHDDGPITVRAGRYGPYVNQGKVNATLPKDLAPEAVTLEKALELIAAKGGSKSKAKAKPKPAAKKPAAKKTATKKPAAKKKAEA
(503) DNA topoisomerase 1 [Mesorhizobium ciceri biovar biserrulae WSM1271]
1
MDVVVVESPAKAKTINKYLGKNYKVLASFGHIRDLPAKDGSVRPDEDFAMSWAVDTASGKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLKQKRALKDKPVSRVVFNAITKSSVLEAMANPRQIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFIREEYWQIAALLGTPRNENFEARLTAFDRKKLQKLDISNKAQADDIKSMLEGATFKAVSVEAKPTKRNPGPPFTTSTLQQAASSGLGFSASRTMQVAQRLYEGMEIGGETTGLITYMRTDGVQMAPEAIDAARDAIAKEFGPKYLPEKPRQYTAKAKNAQEAHEAIRPTDFMRTPASVRQYLDSDQMRLYELIWKRAIASQMQPAEIERTTAEIEAVNGSRTAELRAIGSVVRFDGFIAAYTDQKDDDAEDEENRRLPEIRAGEQLARQAINATQHTTEPPPRYSEASLIKKLEELGIGRPSTYTAILKTLEDRDYVTIDKRRLVPQAKGRLLSAFLESFFKRYVEYDFTASLEEKLDEISDGKLAWKDVLRDFWKDFSGAVADIKELRVTDVLDALNEELAPLVFPAREDGSNPRICPKCGTGNLSLKLGKFGAFVGCSNYPECSFTRQLGDAANPNGENGGGEDGTKVIGKDPYTSEEITLRSGRFGPYLQRGDGKEAKRSSLPKGWTAESIDHEKALALLSLPRDVGQHPETAKMISAGLGRYGPFVLHDGTYANLESIEDVFSIGLNRAVSVIAEKQLKGKGGRNGGTAAALKELGDHPDGGGKIVVRDGKYGPYVNFGKVNATLPKGKDPQSVTMEDALALIAEKEAKGGGGKKPFRKAAAAKAPATKKVAAKKPAAKKPAAKKKG
(662) DNA topoisomerase 1 [Mesorhizobium opportunistum WSM2075]
1
MDVVVVESPAKAKTINKYLGKNYKVLASFGHVRDLPAKDGSVRPDEDFAMSWAVDTASGKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLKQKRALKDKPVSRVVFNAITKSSVLEAMANPRQIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFIREEYWQIAAILGTPRNEAFEARLTAFERKKLQKLDISNKAQADDVKAMLEGAAFKALSVEAKPTKRNPGPPFTTSTLQQAASSGLGFSATRTMQVAQRLYEGMEIGGETTGLITYMRTDGVQMAPEAIDAARDAIAKEFGPKYLPEKPRVYTTKAKNAQEAHEAIRPTDFMRTPASVRQYLDSDQMRLYELIWKRAISSQMQPAEIERTTVEIEAVNGSRTAELRAVGSVVRFDGFIAAYTDQKEDDAEDEENRRLPEIRVGEQLARQAINATQHTTEPPPRYSEATLIKKLEELGIGRPSTYTAILKTLEDRDYVTIDKRRLVPQAKGRLLSAFLESFFERYVEYDFTASLEEKLDEISDGKLAWKDVLRDFWKDFSGAVADIKELRVTDVLDALNEELAPLVFPAREDGSNPRICPKCGTGNLSLKLGKFGAFVGCSNYPECSFTRQLGDAANPNGENGGGEDGTKVLGKDPYTAEEITLRSGRFGPYIQRGDGKEAKRSSLPKGWTPESIDHEKALALLSLPRDVGKHPESGKMISAGLGRYGPFVLHDGTYANVDSIEDVFSIGLNRAVTVIAEKQSKAKGGRNGGTAAALKELGDHPDGGGKIVVRDGKYGPYVNFGKVNATLPKGKDPQSVTIEDALALIAEREAKGGGGKKPFRKAASPATKKAATKKPAAKKKG
(47) DNA topoisomerase 1 [Chelativorans sp. BNC1]
1
MDVVVVESPAKAKTINKYLGKDYKVLASFGHVRDLPAKDGSVRPEEDFAMSWEVDSPSAKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLRQKRALKDKPVRRVVFNAITKKAILDAMASPREVDASLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDLEAEIERFVREDYWQIAALLDTPRGDSFEARLTTLDGKRLQKLDIKSQEEADSIKALLDGAAYRVLSVEAKPTRRNPGPPFTTSTLQQAASSRLSFSASRTMQVAQRLYEGVEIGGETTGLITYMRTDGVQMAPEAIEAARSAVSNTFGPRYLPEKPRHYSSKAKNAQEAHEAIRPTDFSRTPDEVRKYLDSDQARLYEMIWKRAIASQMEAAEIERTTVEIEASGAGRAAGLRAVGSVVRFDGFLAAYAEVKDEDSQDEEDRRLPEINSGEALKRNSVNVTKHTTEPPPRYSEASLIKKLEELGIGRPSTYAAILKTLDDRGYVSNERRKLVPQAKGRIVTAFLENFFRRYVEYDFTADLEEKLDEISDGKLSWKQVLRDFWKDFSAAVGDIKELRVTDVLDALNEELAPLVFPTREDGGDPRICPKCGAGKLSLKLGRYGAFVGCSNYPECDYTRQLGENPAENGEAEAGLNGNKVLGTDPFTGEEITLRSGRFGPYVQRGEGKDAKRAGLPKGWTPEDLDHEKAIALLSLPRDVGKHPETGKMISAGIGRYGPFLLHDGTYANLETVEDVFSVGLNRAVSLLAEKQAKTNGARAKPAALKELGEHPDGGVITVRDGRFGPYVNVGKVNATLPKGKDPMSLTREEALELLAAKAGKTGKKPAKSKARS
(1004) DNA topoisomerase 1 [Azorhizobium caulinodans ORS 571]
1
MQVVIVESPAKAKTINKYLGPGYEVIASYGHIRDLPSKDGSVDPEADFRMLWEVDPKAQKRLNDIAKAVKVADGLILATDPDREGEAISWHVLEVLREKKALKGQKVERVVFNAITKQAVLEAMKAPRAVDVALVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIELFVAKEYWSIAATLATPRGDTFEARLSGADGKKITRLSVGTAEEAAAFRAALDTAAFSVRNVEAKPVRRHPQPPFTTSTLQQEASRKLGLAPARTMQIAQRLYEGVDIGGETAGLITYMRTDGVDMAPEAVTATRNAISAQYGARYLPGTPRKYTTKAKNAQEAHEAIRPTDPSRHPREMARHLDAEQARLYELIWTRTIASQMESAELERTTADIIAKAAGRELELTATGTVVKFDGFLTLYREGKDDEDDDEESRRLPAMSAGEALDKREIKTDQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLAVLRDREYVKLEKKRLVPEDKGRLVTAFLQSFFKKYVEYDFTADLEEKLDEISAAEIDWKQVLRDFWNDFSLAVDATKELRVSQVIDALDEILTAHLFPAKEDGSDPRLCPTCGSGRLSLKMGKFGAFIGCSNYPECRYTRPLSGGEGEAGGDGVRKLGTDPETGLEVTLRDGRFGAYLQLGEAVDGEKPKRSSLPKGLAPADVDLETALALLALPRRVGTHPEDGEPILAGIGRFGPYIQHGKVYANLEAADDVLTVGLNRAVVLLAEKQSRGRGGRGAAPAGRTLGDHPTEGGAITVRAGRFGPYVNHGKINATLPKSQDPDSLTLEQALALIEAKAAASPSARKPARKSASADGAAKKAPAKKTATKTAAKKTTTKAAGTKKTAKAKADAAAEE
(183) DNA topoisomerase 1 [Starkeya novella DSM 506]
1
MQVVIVESPAKAKTINKYLGPGYEVIASYGHVRDLPAKDGSVDPEHDFHMLWDIDPKAQKRLSDIARAVKGADGLILATDPDREGEAISWHVLEILKEKRALKDQPISRVVFNAITKQAVLDAMAHPRTIDAALVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIETFVKREYWSIAATLATPRNETFEARLVGADGKKITRLDVGTEAEATDFRKALESADFKVRSVEAKPARRHPYPPFTTSTLQQEASRKLGLAPAVTMRIAQRLYEGVDVGGETVGLITYMRTDGVDMAPEAVAQARSVIGRDYGDRYVPNAPRKYTAKAKNAQEAHEAVRPTDLSRRPKDVSRHLEPEQAKLYELIWLRTVASQMESAELERTTVDIDAKAAGRALELRATGQVVKFDGFLTLYREGIDDGDEDEENRRLPAMSTGEALANKGIKADQHFTEPPPRYSEASLVKRMEELGIGRPSTYASVLAVLRDREYVKLDKRRLVPEDKGRLVTAFLESFFDRYVEYDFTADLEEKLDLISNGELAWKDVLRDFWRDFTAAVGETKELRVSDVISALDEMLTAHIFPPKEDGSDPRICPTCGTGRLSLKVGKFGAFIGCSNYPECKYTRPLAVQNGDSDNPAEANGTRVLGTDPVSGLEVTVRDGRFGAYLQLGEAKDGEKPKRSSLPKGLAPADVDLETGLALLSLPREIGVHPDNGEPILAGIGRFGPYVQHGRTYANLEAGDDVLSIGLNRAVALIADKQNKGPGRGRGAVGGRELGEHPTLGGQVTVRPGRFGAYVNHGKVNATLPKSMPAESVTLEQAVELITAKAGSAPAKPARRAAAKTASGDKPAKKAAPKKAAAKKSPAKKSG
(1057) DNA topoisomerase 1 [Candidatus Liberibacter solanacearum CLso-ZC1]
1
MNVIIVESPAKAKTISKYLGPDYKVLSSFGHVRDLPAKKGSVLPEKNFEMLWETDKSSQKHLENIISAVKSSTLLILATDPDREGEAISWHVLDILRQRNLIGERKIKRVSFNAITKKVVLNAMENTRDLNLDLVNAYLARRALDYLVGFNLSPILWRKLPGARSAGRVQSVALRLICHRENQIECFVSEEYWLLSVLLETPRGDKFIARLVDFNGQRIEKTSIGNKKEADKLISFLEKATYIVKNTETKPIKRNPWPAFTTSTLQQAASSRLGFSPSYTMRIAQKLYEGIDVNGEVVGLITYMRTDSVHLSLDALEEVRRSISSNFGNSYLPDKPRIYSVKAKNAQEAHEAIRPNDFNFLPSEMKKFLDSDQFQLYNLIWKRSVASQMASAEFERTTISIDATYEDQIAHLRTVGSCLRFDGFLKVWENQNDQENNSDEDKLLPCINKNEKLLAKETNASQHFTEAPLRYSESSLIKKMEELGIGRPSTYAAILETLSKRRYIVIEKRKLFPQNTGRIVTAFLENFFSRYVEYDFTADLEEKLDKISSGKLDWKEVLHEFWKEFIEKIDSTKELRTSNVLDILNDTLSSVIFPAKDNNEDSRTCPSCQKNPLSIKLSSKYGAFVGCTNYPECKYTRQLTTSNQQYIEENLEPLLLGDDPETKEPITLRSGRFGFYVQRGDGKDAKRCGLPKNWDRESIDYDKALSLISLPREIGIHPETQKSIIASMGKYGCYLKHDGHHTKLESIEQVLTINLDQAISCMIQKNKKEKSSRTSTKNQGHVIGIHPEGGSITIHRGRYGPYLNWGKINASIPNNENPDTIDLENALKIFETKIKGKKKS
(1309) DNA topoisomerase 1 [Bartonella clarridgeiae 73]
1
MNIVIVESPAKAKTINKYLGSQYKVIASFGHVRDLSAKDGSVLPDKDFAMKWDIDTASAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDILKQKKVLNNKPIKRVVFNAITKKSVLAAMKNPRDIDISLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICNRESEIEQFIKEDYWSITTYLKTLQDNIFYARLTEFNHKKLGKLDIRSQEQADQIFFMLEKANYRTLSIEAKPIKKNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVEINGETAGLITYMRTDGVQMASEAIDAARKAIIDSFGNHYVPEKPRFYSTKAKNAQEAHEAIRPTDFKRHPNQICNVLDSDQAKLYELIWKRAIASQMRSAEIERTTVEIEAFQEENHANLRAIGSVIHFDGFISAYTDPKEEENSEEDESTRLPQINIGESLKKEKVELTQHTTEPPPRYSESALIKKLEELGIGRPSTYASTLSTLCDRGYIITDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTANLEEKLDLISDGKLSWKDVLHDFWDEFNASITSIQELRIMNVLDVLNVTLAPLAFPTREDGSDCRSCPLCINGQLSLKLGRYGAFVGCSNYPECKYTCQLGTDTKEKSKVVHNDEPIMLGIDPETGKDISLRNGRFGPYIQLGEDKKSKRASLPKGWQIENINFDKALALLSLPREVGTHPETGKIITAAIGRYGPYLAHDGKYANLFSIDEVFDIGINRAITILAEKKNNETNRRRILPTVLTTLGDHPEGGTITIRDGRYGPYVNWNKINATLPRDKDPTTVTLSEALELISAKASTKKTGQKATSKKKLTPKKASPRKEKA
(494) DNA topoisomerase 1 [Bartonella bacilliformis KC583]
1
MDIVIVESPAKAKTINKYLGSQYKVIASFGHVRDLSAKDGSVLPDKDFSMKWDVDTASAKRLNEIAKAVKEANSLILATDPDREGEAISWHILDVLNQKKILNDKPVKRVVFNAITKQSVLDAMNNPRDIDVSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEREHFVKEDYWSITTYLKTPRNDVFQARLIEFNQKKLSKLDIQSQEQANQIRLMLEEAEYCTLSVEAKPTKRNPSPPFTTSTLQQASSSKLGFSASRTMQIAQKLYEGVEMNGETAGLITYMRTDGVQIAPEAIDSARRAISNSFGNNYLPEKPRFYSTKAKNAQEAHEAIRPTDFKRHPDQVRNFLDNDQAKLYELIWKRAIASQMRSAEIERTTVEIKAVQEENYANLRATGSVTRFDGFIAVYTDQRDETNGDEDDLARLPPINVNEILTKEKIETAQHTTDPPPRYSEASLIKKLEELGIGRPSTYASTLATLCDRGYIIIDKRQLTPDAKGRIVTAFLENFFNRYVEYGFTANLEEKLDLISDGKLFWKDVLRDFWDEFNASVTNIQELRITNVLDVLNTTLAPLAFPTREDSSDPRSCSLCKHGQLSLKLGRYGAFVGCSNYPECKYTKQLGTDAGEEREAAHNDEPVILGVDPETGKDIFLRNGRFGPYIQLGEGKEAKRSGLPKGWKTENVNLDKALSLLSLPREVGIHPETGQMITATIGRYGPYLTHDRKYAALSNVDDVFDIGINRAVTVLAEQKENKANRGKTVSSVLAALGDHPDGGSITVRDGRYGSYVNWGKINATLPKDKDPANITLSEALELLSAKTSAPSKTRKVAAKKTAPKKNTTVKKASSTIKKAK
(38) DNA topoisomerase 1 [Bartonella tribocorum CIP 105476]
1
MNIVIVESPAKAKTINKYLGPQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDIDSAAAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDVLRQKKVLKDKPIKRVVFNAITKKSVLDAMNNPRDIDTSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTQLKTIRNDHFQARLTMFNQRKIGKLDIQSQEQADQIRLMLEKAQYHTLSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEVAGLITYMRTDGVQIAPEAIDAARKVIHESFGKDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRSPNQVRNFLDDDQAKLYELIWKRAIASQMCSAEIERTTVEIEAQQGDNRANLRATGSVVRFDGFISVYTDQRDEENNEENETTRLPQINTGEALTKEKVESLQHTTEPPSRYSEASLIKKLEELGIGRPSTYASTLATLCDRGYIVIDKRKLIPDAKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRDFWDGFNTSISNIQELRIANVLDVLNVTLAPLAFPEREDGSDVRSCPLCKNGQLSLKLGRYGAFVGCSNYPECRYTRQLGTTDTEEENEAVRNDEPVMLGIDPETGKDISLRNGRFGPYIQRGESKEVKRAGLPKEWQAENITLERALALLSLPREIGIHPETGKMITATIGRYGPYLSHNGKSARLLHADEVFDIGINRAVTVLAEQQENKTKQSRTTSAALATLGEHPEGGTVTVRNGRYGPYVNWGKINATLPKEKDPISVTLSEALELISAKASSKKAISKRASSKTKAKTKET
(155) DNA topoisomerase 1 [Bartonella quintana str. Toulouse]
1
MNIVIVESPAKAKTINKYLGSQYKVLASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAASKRLNEIAKAVKEADSLILATDPDREGEAISWHILDILRQKKVLKDKPVKRVVFNAITKKSVLDAMNNPRDIDTSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTDLKTIRNEGFQARLTMFNHKKIGKLDIQSQEQADQMRHMLESAKYHTLSVEAKHTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGVEINGEMAGLITYMRTDGVQIAPEAIDSARKVIHEFFGSDYVPEKPRFYSTKAKNTQEAHEAIRPTDFQRIPNQVRNFLDTDQVKLYELIWKRAIASQMRSAEIERTTVEIEAQQGENHANLRATGSVIRFDGFISVYTDQRDEENSEENEITHLPQINTGETLTKEKVEAIQHSTEPPPRYSEASLIKKLEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRNFWDGFNASITNIQELRITNVLDVLNITLAPLIFPGREDGNNVRSCPLCSSGQLSLKLGRYGAFVGCSNYPECKYTRQLGTDPGEEKEVMRNDEPVMLGIDPKTGKDVSLRNGRFGPYIQVGEQKEAKRVRLPKEWQTEKMTLDKALALISLPREIGIHPETGKIITATIGRYGPYLAHDGKYAPLLHADEIFDIGINRAVTVLAEKQENKTKRNRTKTAALATLGDHPDGGTVTIRNGRYGPYVNWGKINATLPKDKDPISVKLSEALELISDKASSKKTTAKKASSKRKET
(1356) DNA topoisomerase 1 [Wolbachia endosymbiont of Drosophila melanogaster]
1
MALLIVESPAKAKTIGKYLSKEFKVAASFGHVRDLPAKNGSVDPDNDFTIKYETIEKAEKYIKELVKAASKTSDIYLATDPDREGEAMAWHVIETLKEKKAISNENNIYRVVFNEITKRAVQEAIKNPREINMDLVRAQQARRALDYLVGFSLSPLLWTKLSGSKSAGRVQSVALKIICEREDEISKFITQEYWSIKAEMQNSKDEAFFAMLSHYDNKKLEKFDIKNEEEAKNLVREIESRQYAVSTVERKQVKRNPLPPFITSSLQQDAVNKLYFNVKSVMRIAQNLYEGIDIGGETVGLITYMRTDGFHIADEAINSIRGSIKSLYGDKYLPQSPRKYVKKVKNAQEAHEAIRPTDINRTPGSIKDYLTPEQFKLYDLIWKRTIASQMESAILDQVVVEISSTDQKVILRASGSSIFFDGFYRVYQDNIEAENEGLLPAMKEGEACKLISVEPKQHFTQPPPRYSEASIVKKMEEIGIGRPSTYATIISVLQDREYVSLDSKRFIPSSRGKIVTIFLETFFQRCVEYDFTAQMEEKLDLISNGHADWKKELGHFWVPFFGHVNSVKQMTHDEVFSGIHDLVIDWFCSEEGRKEVNTKCPACLGGILKLNFGKAGVFLGCSNYPECNHTKEITGSNDNSEYPKSLGIDDITNQEVMIKKGPFGLYLEFNNELKKKKTVSIPKDINVNEIDLSTATQLLSLPKVIGEHPETGKEVKIGLGRFGYYIFYDGRYFSLKKSSKEVLNTELSEAVQIIANSPRKELKSLGVNEKGKEVFICNGRYGFYIKCGKTNVALGKSADIESIDLEKALELIKGKK
(970) DNA topoisomerase 3 [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
10
MRLFIAEKPSLGRAIADVLPKPHKKGDGFIETAQGDVVTWCIGHLLEQAEPDAYDAAYKQWRMESLPIVPSQWQLVAKPKTKTQLTVIKRLLKQADCVVNAGDPDREGQLLVDEVIDFLGYGKTRPVLRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYTLLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFFEVLAHLQTEGNERFSAKWLPSEACLPWQDEEGRVLNRALAAKVVERIQGQPALVEEVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDVCQGLYERHKLITYPRSDSRHLPSDHFNRAGQVREAIASTAPALAKAVSEADGKIRSKAWNDGKVDAHHAIIPTEKQGNPATLGADEAKLYGLIARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGALLEKMTQAPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIIDLLFKRRFLVRQGKSIKGTPTGRALILALPATATTPDMTALWEQHLGRIAERQTSYQQFMGPLTEQLNGLIDGARQDSGASFSALPKAVPGADKRRFTKRKRSTAAGGTSGTAKRGSKRPAKAA
(470) DNA topoisomerase 1 [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
9
MGKSLVIVESPAKAKTINKYLGKDYVVKSSVGHVRDLPTSGSASNEPKKPVIRGIKLSEAEKAAKDRNALFSRMGINPTAGWQANYQILPGKEKVVSELQSLAEKADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKTAIQEAFAQPSELNIHRVNAQQARRFLDRVVGYMVSPLLWKKLARGLSAGRVQSVAVRLIVDKEREIKAFVPVEFWDLNADLLTADKSDLRMEVVSRNGVDFKPVTQAETFAAVAALEGVDYKVVNREDKPTGSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVEAVREYIGEQYGAAYLPSDPNLYGAKANAQEAHEAIRPSSVLVTAEMLEGMEPDAMRLYDLIWRQFVACQMTPAQYDSSTLTVKAGEFELKARGRTLRFAGWTKALPPMGRKGEDSQLPAVTVGEILKLVKLDPRQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIVDRGYVRVESRRFFAEKMGEIVTDRLVENFVELMNYEFTAKMEDKLDGIAEGSLEWKKVLDAFYAEFTQELEKADKAPEEGGMRANQMVLTDIDCPDCGRKMGIRTATTGVFLGCSGYALPPKERCKKTINLVSADEFVSATDGEEAETEALRAKHRCTICGTAMDAYIIDDSRKLHVCGRNPDCDGYEIEKGQFKLKGYEGPSIECDRCGSEMQLKNGRFGKYMGCTNDTCKNTRKILKNGDIAPPKEDPVPLPELKCTQSDAHFVLRDGAAGLFLAASNFPKSRETRAPLVEELKRFKERLSPKHQYLADAPASDPDGNAAIVRFSRKTKEQYVMTEVNGKATGWTAHYDNGKWQESLAKSKKA
(1729) DNA topoisomerase 1 [Aeromonas veronii B565]
9
MGKSLVIVESPAKAKTINKYLGKDYVVKSSVGHVRDLPTSGSASTEPKKPVIRGIKLSESEKAAKDRKALFARMGINPTAGWQANYQILPGKEKVVSELQSLAEKADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKSAIKEAFAQPSELNIDRVNAQQARRFLDRVVGYMVSPLLWKKLARGLSAGRVQSVAVRLIVDKEREIKAFVPVEFWDLNADLLTGDKSDLRMEVVSRNGADFKPVTQAETFAAVAALEGVDYKVVNREDKPTGSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVEAVREYIGEQYGAAYLPAEPNLYGAKANAQEAHEAIRPSNVQVTAEMLEGMEPDAMRLYDLIWRQFVACQMTPAQYDSSTLTVKAGEFELKARGRTLRFAGWTKALPPMGRKGEDSQLPAVTVGEVLKLIKLDPRQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIVDRGYVRVESRRFFAEKMGEIVTDRLVENFVELMNYEFTAKMEDKLDGIADGSLEWKKVLDAFYAEFTQELEKADKAPEEGGMRANQMVMTDIDCPDCGRKMGIRTATTGVFLGCSGYALPPKERCKKTINLVSADEFVSATDGEEAETEALRAKHRCGVCGTAMDAYIIDDSRKLHVCGRNPDCDGYEIEKGQFKLKGYEGPSIECDRCGAEMQLKNGRFGKYMGCTNETCKNTRKILKNGDIAPPKEDPVPLPELKCTQSDAHFVLRDGAAGLFLAASNFPKSRETRAPLVEELKRFKDRISAKHKYLAGAPLTDPDGNPAIVRFSRKTKEQYVMSEVNGKATGWTAHYDNGTWQESLPKAKKA
(1880) DNA topoisomerase 3 [Aeromonas veronii B565]
10
MRLFIAEKPTLGRAIADALPKPHKKGDGFIETAQGDVVTWCIGHLLEQAEPDAYDAAFKQWRMEHLPIIPAQWQLVAKPKTKTQLTVIKRLIKQADCVVNAGDPDREGQLLVDEVIDFLGYPKTKPVQRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYTLLGRKAGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFYEVLAHLLTEGNERFTAKWLPSEACLPWQDEEGRVLNRALADKVVSRINGQPAQVESVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDICQSLYERHKLITYPRSDSRYLPTDHFKRAEQVRGAIAATAPALAKAVSEADGKIRSKAWNDSKVDAHHAIIPTEKQGNPATLGADEAKLYGLIARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGELQEKMTQPPKSFTDATLLAAMTGIARYVQDPEIRKTLRDTDGLGTEATRAGIIDLLFKRRFLVRQGKSIKATPTGRALVQALPATATTPDMTALWEQSLGQIAERHGSYQQFMGPLTEQLNGLIEGARQDSGASFSALPKEAPGAGKRRFTKRKSPAASTTGGPRPRKTASKRQTRAA
(710) DNA topoisomerase 1 [Aeromonas salmonicida subsp. salmonicida A449]
9
MGKSLVIVESPAKAKTINKYLGKDYVVKSSVGHVRDLPTSGSGSNEPKKPVIRGIKLSESEKAAKDRNALFSRMGINPTAGWQANYQILPGKEKVVSELQSLAAKADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKTAIQEAFAQPSELNIHRVNAQQARRFLDRVVGYMVSPLLWKKLARGLSAGRVQSVAVRLIVDKEREIKAFVPVEFWDLNADLLTGDKSDLRMEVVSRNGADFKPVTQAETFAAVAALEGVDYKVVNREDKPTGSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVEALREYIGEQYGAAYLPAEPNLYGSKAGAQEAHEAIRPSSVLVTAEMLEGMEPDAMRLYDLIWRQFVACQMTPAQYDSSTLTVKAGEFELKARGRTLRFAGWTKALPPMGRKGEDSQLPAVTVGEVLKLIKLDPRQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIVDRGYVRVESRRFFAEKMGEIVTDRLVENFVELMNYEFTAKMEDKLDGIAEGSLEWKKVLDAFYEEFTQELAKADRDAEEGGMRANQMVLTDIDCPDCGRKMGIRTATTGVFLGCSGYALPPKERCKKTINLVSADEFVSATDGDEAETEALRAKHRCGVCGTAMDAYIIDDSRKLHVCGRNPDCDGYEIEKGQFKLKGYEGPSIECDRCGSEMQLKNGRFGKYMGCTNETCKNTRKILKNGDIAPPKEDPVPLPELKCTQSDAYFVLRDGAAGLFLAASNFPKSRETRAPLVEELKRFKERLSPKHQYLADAPASDPDGNASIVRFSRKTKEQYVMTEVNGKATGWTAHYDNGKWQESLAKSKKA
(692) DNA topoisomerase 3 [Aeromonas salmonicida subsp. salmonicida A449]
10
MRLFIAEKPSLGRAIADVLPKPHKKGDGFIETAAGDVVTWCIGHLLEQAEPDAYDAAFKQWRMEQLPIIPAQWQLVAKPKTKTQLTVIKRLIKLADCVVNAGDPDREGQLLVDEVIDFLGYPKTRPVQRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYTLLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFYEVLAHLVTDGNERFSAKWLPSEACLPWQDEEGRVLNRALAEKVVSRINGQPASVEEVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDVCQGLYERHKLITYPRSDSRHLPSEHFNRAAQVREAIAATAPALARAVSEADGKIRSKAWNDSKVDAHHAIIPTEKRGNESSLSGDEAKIYGLVARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGELLEKMTQAPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIIDLLFRRRFLVRQGKSIKGTPTGRALILALPTTATTPDMTALWEQSLGQIAERHASYQQFMGPLTDQLNALIEGARQDSGASFSALPKAVPGAGKPHFTRRKSSAGTTGTPRKSAGKRPAKSKAT
(1613) DNA topoisomerase 1 [Aliivibrio salmonicida LFI1238]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPMGSTSTGKKTAAASTKGMSVEDKARIKKERDKKNLINKMGIDPYNDWAANYQILPGKEKVVAELQKLAENADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKNAIQQAFETPGELSMPGVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVKVLVEREREINAFIPEEFWDIHADTLTSGKENFRLQVAQRNGSVFKPLNQADTESAVSILEKAEYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKEAVETLREFIGSEYGESYLPAAPIIYGSKEGAQEAHEAIRPSSVDVKVDDLQGMEADAHKLYNLIWNQFVSCQMTPAQYDSTTLSVKADEFTLKAKGRILKFDGWTRVQRPMGKNEDQLLPAVQLGDKLKLEQLDPKQHFTKPPARFTEAALVKELEKKGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLNQSFDDLMDYDFTARMEGNLDKIAEGSKDWKEVLNAFFQDFTDDIAKAELDESEGGMSPNNIVETDIKCPTCDRNMGIRTASTGVFLGCSGYALPPKERCKKTINLGNEEGIINVLEEDVETAALRAKKRCPKCETAMDPYLIDQDRKLHVCGNNPNCDGYIVEKGEFQLKGYDGPIVECDKCGSDMELKNGRFGKYMDCTSETCKNTRKILRNGDVAPPKEDPVHLPELECEKSDAYFVLRDGASGLFLAASTFPKSRETRAPLVEELVRFKDRLSPKFVYLTEAPTHDPDGKPAVIRFSRKTKENYVRTETDGKPSGWTALYLDGKWAVTDKRKKPKAEKES
(1718) DNA topoisomerase 3 [Aliivibrio salmonicida LFI1238]
10
MSRLFIAEKPSLGRAIAAGLAKPQKNHQGYIECGNGDIVTWCIGHLLEQVEPDAYDDKYKSWRMEHLPIVPEQWQLRPRKSSSKQLTVIRKLLKTASQVIHAGDPDREGQLLVDEVLDYLKLSKTKKAATQRLLISDLNLPAVKRALSAMRSNQEFIPLSISALARSRADWLYGMNMTRAYTLLGQRGGYQGVLSVGRVQTPVLGLVTRRDEEIAHFIPNAYFTLDALIPYHNPNLNGGLPFDIRAKWKPSEACQQWQDEDGRVLNLKLVENVAQRIANQPATVTKAENKETKQNAPLPYSLSALQIDASKRYNLSAQQVLDSCQALYEKHKLITYPRSDSRYLPKDHYKQREQVCAAIGNNDKQLSNAVNNADVNLRSRAWNDSKVDAHHAIIPTPKSSGAAGLSGYEEKVYHLIARQYLMQFYPAAIYAEAELIFDIAGGVFSAKGKQMLFAGWRILLGKTHTQNADDDVANKVPPLKKGEVHTCREGEIKHKMTEPPKYFTEATLLQAMTGIARFVEDKELKKVLRDTDGLGTEATRAGILDTLFKRQLLIRNGKNINASDAGKGLIHALPREATYPDMTAHWEFQLQGMTEKTYSYRPFMQSLETKVTNFMQGVQQGPVPDSLRSLKSPTKPQFKRRKSAKKS
(496) DNA topoisomerase 1 [Rickettsia japonica YH]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPNENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKAIIHAVENPRKLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTEKLKSQKFHVDKIEKKQQKRQPQPPFITASLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAQANGSTIAFDGFYKVYRESMDDKAEEANKMLPPLKEQEPLKTKKVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKPA
(1592) DNA topoisomerase 1 [Ehrlichia ruminantium str. Welgevonden]
1
MSLIIVESPSKAKTIGKYLGSKYKVVASFGHIRDFPAKSGSVDPDKDFAMTYEIIAKSEKYVSKLVQVANKETKEIYLATDPDREGEAIAWHIVEVLREKNAINNNIVINRMVFNEITKNAILASVKNPRNINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRENEIEKFITQEYWDIEAKLQNVEGREFSAYLKCYSGNKLEKFDIKNEEDANRLSAEIRQRSYSVSSVEKKHTKRNPYPPFITSSLQQEASTKLGFSAKSTMLIAQKLYEGVDIGGEIVGLITYMRTDGVYISDEAVEHIRSVISSMFGKEYLPESPRKYVKKIKNAQEAHEAIRPTNITITPDSLVSYLTQEQLKLYDLIWKRTVASQMNSAVLDQVIVELSSLDGIVILRALGSSLSFDGFYKVYGHDDDSKNSILPLLNENDHCPLNDVIPNQHFTNPPARYSEASLVKKMEEIGIGRPSTYASIISVLQDRQYVVLNQKRFFPTERGRVVNIFLVNFFNRYVEYDFTADLEEKLDLISNGKIGWKEVLHQFWFLFIDNVNSVKKLEFTQILNAISSEMESHIFPSDVSEVDKMCPVCNVGTLSLNISKNGVFLGCSQYPECKYTKNIGDSTVDNTEVSQYPRVLGSDAASGEDIYLKKGPYGIYLQIGSGKDGKRATLPKDIDLNLLDLEMAKKILSLPISLGMYPDTNSEIKLGLGKFGAYIFYEGKYFSIKKFEGNFLDITLENAIAIIQKNRTNGVIKSLGMSQDNKEVFLCKGRYGFYLKYDKLNIAIKKGIDVEQMSLVDALKLISEKL
(1593) DNA topoisomerase 1 [Ehrlichia ruminantium str. Welgevonden]
1
MSLIIVESPSKAKTIGKYLGSKYKVVASFGHIRDFPAKSGSVDPDKDFAMTYEIIAKSEKYVSKLVQVANKETKEIYLATDPDREGEAIAWHIVEVLREKNAINNNIVINRMVFNEITKNAILASVKNPRNINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRENEIEKFITQEYWDIEAKLQNVEGREFSAYLKCYSGNKLEKFDIKNEEDANRLSAEIRQRSYSVSSVEKKHTKRNPYPPFITSSLQQEASTKLGFSAKSTMLIAQKLYEGVDIGGEIVGLITYMRTDGVYISDEAVEHIRSVISSMFGKEYLPESPRKYVKKIKNAQEAHEAIRPTNITITPDSLVSYLTQEQLKLYDLIWKRTVASQMNSAVLDQVIVELSSLDGIVILRALGSSLSFDGFYKVYGHDDDSKNSILPLLNENDHCPLNDVIPNQHFTNPPARYSEASLVKKMEEIGIGRPSTYASIISVLQDRQYVVLNQKRFFPTERGRVVNIFLVNFFNRYVEYDFTADLEEKLDLISNGKIGWKEVLHQFWFLFIDNVNSVKKLEFTQILNAISSEMESHIFPSDVSEVDKMCPVCNVGTLSLNISKNGVFLGCSQYPECKYTKNIGDSTVDNTEVSQYPRVLGSDAASGEDIYLKKGPYGIYLQIGSGKDGKRATLPKDIDLNLLDLEMAKKILSLPISLGMYPDTNSEIKLGLGKFGAYIFYEGKYFSIKKFEGNFLDITLENAIAIIQKNRTNGVIKSLGMSQDNKEVFLCKGRYGFYLKYDKLNIAIKKGIDVEQMSLVDALKLISEKL
(794) DNA topoisomerase 1 [Rickettsia bellii RML369-C]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVIPDENFSMKYDISEKAGKYVDAIIKDAKKAESVYLATDPDREGESISWHIAEVIKEKNKVKSDDFFKRVAFNEITKKAITHAIENPRKLDNNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMLNSNNELFTAKLTHINDQKLEKFSITNDKEAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVDEIRKLINKDYGDKYLPSSPRIYKSKVKNAQEAHEAIRPTNINYIPNDLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVNATLASENKEYLARANGSTIAFDGFYKVYRESIDDEAEEENKMLPPLKEQEHLKTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYATILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKSALGNFWNGFNHNIESVNKQNITEIISYVQQALDYHIFGENKDSKVCPSCKTGELSLKLGKFGAFLACSNYPECNFRKSIVSGNDNNEADGEAKDIVNENKVLGKDKEGIEIYLKKGPYGPYIQYGEQVDSKIKPKRSPLPAGLNQNDITLDMALKLLSLPLKIGNHKESGEEVLVGYGKFGPYIKYMGKFISIPKKYDFLNLSLDDAMKLIEEKLNAIAAKQPNPLNMDEVTNLVDKKIKVKKTKK
(932) DNA topoisomerase 1 [Rickettsia typhi str. Wilmington]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDKNFAMEYDISDKASKYVDAIVKYARKAEAVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICDREDEIERFKAEEYWDISLKMQNSNNELFTAKLTHVNDQKLKKFSIINEKEAKDLTRKLKLQKFYVEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGNKYLPINPRIYQSKVKNAQEAHEAIRPTNITYTPDNLKQKLEKDYYKLYELIWQRTIACQMENVIMDLVIANLASENKEYLAKANGSIIAFDGFYKVYRESLDDEDEEDNKMLPPLKAQEHIKTKEVIPNKHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKTSLNNFWSGFNNNIESVNEQKITEIINYLQKALDYHLFGENKESKVCPSCKTGQLSLKLGKFGAFLACSNYPECTFKKSIVSGNDNNEDEGNLSTILNDNKILGTDKDGVEIYLKTGPYGPYIQLGEQCGKVKPKRTPVPTNLKQSEITLEVALKLLSLPLKIGIHKDSGEEIIIGYSKFGPYIKYMCKFISVPKKYDFLNLNLDDAIKLIENNKAKLEKKHRSMV
(1052) DNA topoisomerase 1 [Orientia tsutsugamushi str. Ikeda]
1
MKLLIVESPAKAKTINKYLGSDFQVVASYGHVRDLLAKAGSVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATDPDREGESISWHIVEVLKEKKIFANFKRIIFNEITKKAIGDALQQPRDINLNLVNAQQARRSLDYLVGFSLSPLLWRKLPGCKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKLIEFDGNKLEKFSITNQSQAQDIVKNIENQQFKVIDITRKQRKKSPPPPFITSSLQQEAAGKLGFTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNFISSSFGSNYLPKQIRAFKSKVKNAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQRTVACQMENVILNLESINFASFNQLHVAKATGSTIAFDGFYKVYKEINDEEENKKLLPNLSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLGIGRPSTYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSIAKGMIEWQEILKNFWTGFNNNVQEIEQYKITDIIPQIETLLSNFLFPAQNDETDHKLCTLCKVGKLSLKLSKYGAFLACDNYPSCNFTRNIAAAFENNDNLPKGKNNKAIGYSDDMQKTIYLKEGPFGWYIQAGEDSTNKNDKPKRVPISVISSSPQDITLETAVKLLALPKVIGLNPNTNKEITVAVGRYGPYLKHDGKFISIPKNYDYLNLSINDCIKIITSSSSQLRKAKKDAPTNSDKVAKSKS
(508) DNA topoisomerase 1 [Anaplasma centrale str. Israel]
1
MMGVVIVESPSKAKTISKYLGGKYKVVASFGHVRDFPAKSGSVDPDDDFRMIYEIIPKSEKYIDKIVKAVSSEKSGIYLATDPDREGEAIAWHIIEVLRERSAIGGDVAINRMVFNEVTKRAVTAAISDCRSINMDLVHAQQARRVLDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLVCEREHEIERFDSKEYWNIEVLLKSKSGEELTAALKCYNGEKLDKFAIPNADSASAIAEHVRNGTYHVASVEAKRTKRNPHPPFITSSLQQEASTKLGFSAKNTMMVAQKLYEGIDIGGETVGLITYMRTDGFYISSEAISYIRDTIKMQFGEQYLTKSPRKYVKKVKNAQEAHEAIRPTDITMTPDSLAQYLSEDQLKLYDLIWRRTMASQMESAVIDQVIVDIQSKDGSVVLHAVGSSLGFDGYQRVYGTDDDDKRKMLPKLEAGEDCSLVEVSPSQHFTQPPPRYSEASLVKKMEEIGIGRPSTYATIISVLQERGYTQLEQKKFVPSERGRIVNAFLTNFFGRYVEYDFTANLEEELDLISNGNMAWKEVLRRFWDKFISDVSTVKGIEVSEILKSITKDLEEYAFSPNAGEAVNRSCPGCGEGELMLNIGKYKAFLGCNRYPECKYTRGVGGDSGVCRDEFPKVLGLDDATQEEIILKHGPYGEYLQLGDNAKGKRVAVPQGIQEITLDVAKKLLSLPITLGHYPNTAQDVKLGTGRFGPYVLYGGTYFSVKGREDFWNLTFEEAVNVIDSQAQKKSKLLGLHDNGKEIYVCKGRYGFYLKCDKKNVAIKGKGGDITLEDAVSLLNQKP
(534) DNA topoisomerase 1 [Anaplasma phagocytophilum str. HZ]
1
MGVVIVESPSKAKTISKYLGKKFNVIASFGHIRDFPAKSGSVDPSNDFKMIYEIIPKSEKHLDKIVKTVSAEKEAIYLATDPDREGEAIAWHIVEVLKEKCAIAKDVTVNRMVFNEVTKRAVTAAVDNCRPINMDLVRAQQTRRVLDYLVGFTLSPLLWRKLPGSRSAGRVQSVALRLLCEREYEVEQFKTQEYWDVGVDLQNQGGEKFEAVLKCYAGEKLEKFSIGTEEQAKEYAETVKNQSYTVESVESKKTKRNPYPPFITSSLQQEASTKLGFSAKNTMMIAQKLYEGIDIGGEIVGLITYMRTDGFYISEDAVNYIRDTIKMQFGEKYLSKSVRNYTKKVKNAQEAHEAIRPTDITMLPEQLSKYLTDEQLKLYTLIWKRTLATQMESAVIDQVAVDIKSSCGKISLHATGSTLSFDGYYRVYGSEDSDKRRMLPQLREGESCELLEVHPNQHFTQPPARYSEASLVKKMEEIGIGRPSTYATIISVLQERGYTQLEQKRFIPSERGRIVNAFLTNFFRKYVEYDFTANLEEELDLISNGKMVWKEVLSQFWDKFISDVSSVKTIEASEILKAITRDLENYAFSSVDGESISRVCPQCGSGELMLNIGKTSAFLGCNRYPECRYTRGIGGDGSASPADDASRILGIDEETQEEIFLKRGPYGEYLQLGNSTKRVSLTKSAGEITVDLAKKMLSLPLVLGCYPDTDKEIKLGIGRFGPYLFYNGVYFSIKDREDYINISHQEAVEIIDKQSDKKAKLLGQNKDGKDIYVCKGRYGFYLKCDKTSVALKGRSEDITLEDAILLLSQKQ
(1552) DNA topoisomerase 1 [Ehrlichia canis str. Jake]
1
MSLIIVESPSKAKTIGKYLGSKYKVVASFGHIRDFPAKSGSVNPDKDFAMTYEIISKSEKYVNKLIQVASKETHGIYLATDPDREGEAIAWHIVEVLKENNAIDDNVVINRMVFNEVTKNAILESIKHPRSINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRESDIEKFVTQEYWDIEAKCQNVEGKQFSAFLSYYAGKKLEKFDIKNEEDAKRLAEEVKSRNYSVVKVEKKHTKRNPYPPFITSSLQQEASTKLGFTAKNTMLIAQKLYEGIDVGGEIVGLITYMRTDGFYIADEALDHIRSIIVSIFGKEYLPASARKYVKKVKNAQEAHEAIRPTNITITPDSLSNYLTPEQLKLYDLIWKRTVASQMNSAIIDQVVVELASSDKVVTLRATGSSLFFDGFYKVYGHNEDDDNKNNMLPLLQVSDECPLNEVIPHQHFTIPPARYNEASLVKKMEEIGIGRPSTYASIISVLQDRQYVILNQKKFFPTERGRIVNIFLVNFFSRYVEYDFTADLEEELDLISNGKINWKKVLHKFWFLFIDNVNSVKKLEFTEILKVISCEMENYIFSSDKSETGRVCPACNDGTLGLNISKNGIFLGCSGYPECKYTKNVGGDLVDDVDNVQYPKVLGIDTATCQEIYLKKGPYGVYLQIGSDKNGKRAAIPKNMNANLLDLQMAEKILNLPISLGTHPETCKEIKLGLGKFGAYILYEGKYFSIKNESNFLDVKLEDAIDIIANSSTNGVIRSLGISEDNKEVLLCKGRYGFYLKYDKLNVALKKGTDVEQMSLSDAMKLISEKK
(1230) DNA topoisomerase 1 [Wolbachia endosymbiont strain TRS of Brugia malayi]
1
MALLIVESPAKARTISKYLSKEFKVAASFGHVRDLPVKNGSVDPDNDFAIKYEIIEKAEKYVKELVKEASQTSDIYLATDPDREGEAIAWNVIEALKERKAINDKSNIYRVVFNEITKRAVQEAVKNPREINMDLVRAQQARRALDYLVGFSLSPLLWTKLSGSKSAGRVQSVALKLICEREDEISKFVSQEYWSIRAEIKDSKGETFFAMLSHYDNKKLEKFDIKNEEEAKGLVKQIESRQYAVSTVERKQVKRNPLPPFITSSLQQDAVNKLYFNVKNVMRIAQDLYEGIDIGGETVGLITYMRTDGFYIADEAVNSIRRSIKSLYGNKYLPKSSRQYVKKVKNAQEAHEAIRPTDIDRTPDSIKDYLTPEQFKLYGLIWKRTIASQMESAILDQVVVEISSTDQKVILRASGSIIFFDGFYKVYKNNVDGEDESMIPTMKEGEECKLISVDPEQHFTQPPSRYSEASIVKKMEEIGIGRPSTYAAIISVLQDREYVTLDNKRFIPSSRGKIVTIFLETFFQRCVEYDFTAQMEEKLDLISNGRADWKKELGYFWVPFFNHVNSVKQMTHDEIFNGIRDLVVDWFCSEEGKKEVNKKCPDCPDGILKLNFGKAGVFLGCSNYPTCTHTKEITGSNDNSEYPKSLGIDGVTEQEVVIKKGPFGLYLEFNSESEKKKTVSIPKDINVNDIDLSTATRLLSLPKVIGEHPETGKEVKIGLGRFGYYIFYDSKYFSLKKSFKEVLEIQLDEAVQIIANSPRKELKSLGFNEKGKEVFICNGRYGFYIKCGKTNVALGKNADIESVDLRRALELIKSKK
(23) DNA topoisomerase 1 [Bradyrhizobium japonicum USDA 6]
1
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDANFKMIWEVDPKAAGRLNDIAKSLKGADRLILATDPDREGEAISWHVLEVLKEKRALKDQKIERVVFNAITKQAVTDAMKNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVPREYWSLIATLLTPRGDAFEARLVGADGKKIQRLDVGSGAEAEDFKKALEAAAYAVTAVDAKPARRNPQAPFTTSTLQQEASRKYGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDPSAITQARKVIGEDYGNAYVPEAPRQYQAKAKNAQEAHEAIRPTDMSRRPDSMSRKLDADQARLYELIWKRTIASQMESAELERTTVDITAKAGSRTLELRATGQVVKFDGFLALYQEGRDDEEDEDSRRLPAMSPNDALKRQSLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLHGEDKGRVVVAFLESFFNRYVEYDFTANLEEQLDRISNNEISWQQVLKDFWTGFIGAVDEIKDLRVAQVLDVLDDMLGQHIYPPRADGGDIRQCPSCGNGRLNLKAGKFGAFVGCSNYPECRYTRQLAADSETTADRSLGQDPDTGRDVWVKAGRFGPYIQLGEPKDYEEGEKPKRAGIPKGTSPGDVELELALKLLSLPREIGKHPETGQPITAGLGRFGPFVKHEKTYASLESGDEVFDIGLNRAVTLIAEKVAKGPSRRFGADPGKAIGDHPTLGTVTVKSGRYGAYVTAGGVNATIPAEFEKDTVTLPQAIALIDERAAKGGGKTKAKKAAKPAKAKKAAEKAADGDDAAPKPKKPAAKKAAKPKSESTSKARAAVSSTAKTSPTKAAAPKAPAKKSAGKT
(942) DNA topoisomerase 1 [Bradyrhizobium sp. ORS 278]
1
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPEENFRMIWEVDPKAAGRLNDIAKSLKGADRLILATDPDREGEAISWHVLEVMKEKRALKDQKIERVVFNAITKQAVSEAMKNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVPREYWSLIATLATPRGDTFEARLVGADGKKIQRLDIGTGAEAEDFKNALNAATYSVATVDAKPARRNPQAPFTTSTLQQEASRKLGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIAPEAITQARKVIGEIYGNKYVPDSPRQYQTKAKNAQEAHEAIRPTDLSRKPAELRKRLDDDQAKLYELIWTRTIASQMESAELERTTVDIVAKAGGRTLELRATGQVIKFDGFLALYQEGRDDEEDEDSRRLPQMSQGEALKRQNLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILDVLKARGYVKLEKKRLHGEDKGRVVIAFLENFFRRYVEYDFTADLEEQLDRISNNEIAWQQVLKDFWTGFIGAVDDIKDLRVAQVLDALDEMLGPHIYPPREDGGDVRQCPTCGTGRLNLKAGKFGAFVGCSNYPECRYTRPLAADSEAAADRMLGQDPDSGLEVAVKAGRFGPYIQLGEQKDYAEGEKPKRAGIPKGTQPSDVDLDLALKLLSLPREIGKHPETGLPITAGLGRFGPFVKHDKTYASLEAGDEVFDIGLNRAVTLIAEKVAKGPSKRFGADPGKALGDHPSLGPVAVKAGRYGAYVTAGGVNATIPGDKEKDTITLAEAIALIDERAAKGGGKAKAPKKAAKPKAAAKPKAGGDDDTPKPAKKAVAKKAAAKPKSDSTSKARAPVAKAAKTSAKPATKATPKKSAGKARG
(1368) DNA topoisomerase 1 [Bradyrhizobium diazoefficiens USDA 110]
1
MNIVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDANFKMIWEVDPKAAGRLNDIAKSLKNADRLILATDPDREGEAISWHVLEVLKEKRALKDQKIERVVFNAITKQAVTDAMKHPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVAREYWSLVATLLTPRGDAFEARLVGADGKKIQRLDIGTGAEAENFKKALEAAAYAVTAVDAKPARRNPQAPFTTSTLQQEASRKYGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDPSAITQARKVIGEDYGNAYVPEAPRQYQAKAKNAQEAHEAIRPTDMSRRPDSMSRKLDSDQARLYELIWKRTIASQMEAAELERTTVDITAKAGGRTLELRATGQVVKFDGFLALYQEGRDDEEDEDSRRLPAMSAGDGLKRQSLAVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLHGEDKGRVVVAFLESFFSRYVEYDFTANLEEQLDRISNNEISWQQVLKDFWNGFIGAVDEIKDLRVAQVLDVLDDMLGQHIYPPRADGGDIRQCPSCGNGRLNLKAGKFGAFVGCSNYPECRYTRQLAADSEATADRSLGQDPDTGRDVWVKAGRFGPYIQLGEQKDYEEGEKPKRAGIPKGTSPGDVELELALKLLSLPREIGKHPETGQPITAGLGRFGPFVKHEKTYASLEAGDEVFDIGLNRAVTLIAEKVAKGPSRRFGADPGKAIGDHPTLGTVTVKSGRYGAICHRRRRQRDDPGRVRKGHRHAAAGDRTD
(280) DNA topoisomerase 1 [Nitrobacter hamburgensis X14]
1
MFAPKPSAHLSRNRPRVFPLSYWNNMNIVIVESPAKAKTINKYLGASYEVLASFGHVRDLPAKNGSVDPDANFQMIWEVDPKAVGRLNDIAKSLKGADKLILATDPDREGEAISWHVLEVLKQKRALKDQKIERVVFNAITKQAVTDAMKNPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCSREIEIEKFVPREYWSLIATLATPRGDTFEARLVGADGKKIQRLDIGSGAEAEDFRKAIEAANFIVSTVEAKPARRNPQAPFTTSTLQQEASRKLGFAPAHTMRIAQRLYEGIDIGGETTGLITYMRTDGVQIDGSAITQARKVIGEDYGNAYVPDAPRQYQTKAKNAQEAHEAIRPTDLSRRPADMKRRLDADQARLYELIWIRTIASQMESAELERTTVDIAARAGSRVLELRASGQVIKFDGFLALYQEGRDDEEDEDSRRLPAMSDGEALRRENLSVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLYGEDKGRVVVAFLENFFARYVEYDFTANLEEQLDRISNNEVSWQQVLKDFWNDFIGVVNEIKDVRVSEVLDVLDNMLGPHIYAPREDGGDPRQCPTCGTGKLNLKAGKFGAFVGCSNYPECRYTRPLAADGEAGGDRILGKDPESGLDVTVKSGRFGPYIQLGEPSDYGEGEKPKRAGIPKNTSPADMELDLAVKLLSLPREIGKHPETGEPITAGIGRFGPFVRHEKTYASLEAGDEVFDIGLNRAVTLIAEKIAKGPSRRFGADPGKPLGEHPTLGSVAVKSGRYGAYVTAGGVNATIPSDKTQDTITLPEAIALIDERAAKGGGKPKRAAKKAKSAGTERTGKAGAVAAKPAKKAAAKQASVKPKSAAVSKARGSIAAVKPPAKAEKAPAKKSAGKNG
(225) DNA topoisomerase 3 [Vibrio parahaemolyticus RIMD 2210633]
10
MSRLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERYKKWNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCKLSKTKKEATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDQNGAFDIRARWKPSEACKPWQDEEGRVLNRKLVENVANRIANQPAIVKESEQKQTKQSAPLPYSLSALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPLEHYSQAGTVTSAIANNAKELQSAVNGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQFYPAAVYAEAKLVFDIAGGIFIAKGRQLVSPGWKALMGKTDKEDEGIDTVPPLSEGTVLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGILDTLFKRQLLTRQGKSILSSQAGRGLINALPQDATYPDMTAHWEHQLQGMAERNQAYQPFMQALEQRIDGLMSQVKSGPIPDSLRHLPKVERPAFKRKKRSYPNSGASKAGASKRKSS
(1253) DNA topoisomerase 1 [Vibrio parahaemolyticus RIMD 2210633]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQSTGEKKAAAISTKGMSAEEKARVKKEKDRKALIKKMGINPYHDWEANYQILPGKEKVVSELQKLAKDADCVYLATDLDREGEAIAWHLREIIGGDEERYKRVVFNEITKNAIQQAFQTPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFVPEEFWDIHANTKTKDKSDFKLLVAQKDGVAFKPVNETETKAAISVLENASYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVDAVRDFIGSEFGDKYLPAKPLTYGSKEGAQEAHEAIRPSDVSVKAEDLQGVDADAHKLYSLIWNQFVACQMTPAEYDSTTISVKAAEYTLKAKGRILKFDGWTRVQRPMGKNEDTILPAVQLGDKLSLESLDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEQKLDQIAEGEVNWKAVLDNFFADFTGDLEKAELDESEGGMKLNHIVMTDIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEEGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYVVEYGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHFPELPCENSDAYFVLRDGASGLFMAASNFPKSRETRAPLVSELARFEERLPEKFKYLTTAPQEDPDGRPAVVRFSRKTKENYVRSEDDGKPSGWTALYVDGKWEITDKRKKAKA
(612) DNA topoisomerase 3 [Vibrio anguillarum 775]
10
MTRLFIAEKPSLGRAIADALPKPHKKDQGFIRCANGDIVTWCIGHLLEQVEPDVYDERYKKWNLLDLPIIPSQWQLRPRKTSSKQLTVIRQLLKEASQIIHAGDPDREGQLLVDEVIDYCKVSQSKKEQALRLLISDLNLPAVQRALKQMRSNREFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPILGLVVRRDEEIENFIPRDYFTLHALIPYQTDQVAFDIRARWKPSDACQPWQDEEGRVLNRKLVENVAQRIAGQPATVIEAEQKQTKQAAPLPYSLSALQIDAAKRFAMSAQQVLDTCQSLYEKHKLITYPRSDCRYLPQEHYAQASSVTQAIACNAKELLTSVSGANLALKSKAWNDKKVDAHHAIIPTPKQTSVNALSGNEMKIYQLIARQYLMQFYPAAVYAEAKLVFDIAGGFFVASGRQLVDTGWKSLLGKVDEEENGVDAVPPLSKGTVLTCREGEIHDRKTEPPRHFTEATLLQAMTGIARYVEDKELKKILRETDGLGTEATRAGILDTLFKRQLLTRQGKLILSSPAGRGLIHALPNESTYPDMTAHWEHQLQAMAERGQAYQPFMQVLQERIIQIMEQAKSGAVPESLRSLPKVERPAFKRKTRKSSKTTRYQRNSAQ
(1695) DNA topoisomerase 1 [Vibrio anguillarum 775]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQSTAKKATSSSSSKNLSAEEKARLKSEKDRSSLIKKMGIDPYHGWEANYQILPGKEKVVAELQKLAKDADCIYLATDLDREGEAIAWHLREIIGGDEQRYKRVVFNEITKNAIQQAFQTPGELNIDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFVPEEFWDIHADTKTQDKTDFRLLVAQKNDVAFKPVNEAEAKSAVSILEKASYEVCKREDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVEAVRSYIGSEFGQAYLPENPLAYGSKQGAQEAHEAIRPSSVDVKADDLQGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEFTLKAKGRILKFDGWTRVQRPMGKNEDQILPPVKVGETLLLQTLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEEKLDQIAAGSANWKGVLDDFFKDFTADLETAELDEEQGGMKPNHIVMTDIQCPTCSRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEEGVINVLEEDVETAALRAKKRCPICETAMDAYLIDDTRKMHVCGNNPNCEGYVVEFGEFKVKGYDGPVVECDKCGSNMVLKNGRFGKYMDCTSDDCKNTRKILRSGEVAPPKEDPIHFPELPCENSDAYFVLRDGASGLFLAASNFPKSRETRAPLVEELARFKERLAPKYQYLADAPAHDPDGVAAVVRFSRKSKEHYVRTEIDGKPSGWTALYDNGRWEITDKRKNAKK
(1115) DNA topoisomerase 1 [Polymorphum gilvum SL003B-26A1]
1
MESPAKAKTINKYLGSGYQVLASYGHVRDLPAKDGSVKPDEDFAMSWEVDSKSQKRLNEIAAAVKDADRLILATDPDREGEAISWHVLEVLHKKRVLKDKPVERVVFNAITKQAILEAMKHPRAIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLICDREMEIETFVKEEYWSILANLKTPSAEVLQAGLTGFDGRKIGRLDIKTGDEAETIRRMLEAARYTVASVVSKPAKRHPQPPFTTSTLQQEASRKLGFAAARTMQVAQKLYEGVAIGGETTGLITYMRTDGVQIAGEAISATRKVIGQDFGDNYVPEKPRFYSSKAKNAQEAHEAIRPTDLARRPRDVARFLDPDQARLYELIWKRTMASQMESAVLERTTIDIDAAGAGKTATLRATGSVVRFDGFLALYQEGRDDEEDEAARRLPAVDDGAPLALAAVEGKPSAIEADQHFTTPPPRYTEASLVKKMEELGIGRPSTYASTLQTLRDRDYVAFDKKQLVPQDKGRIVTAFLESFFNRYVEYDFTASLEEQLDRISAGELSWREVLANFWRDFSASVDETKDLRVSQVIDALNDLLAAHIFPPREDGKDPRACPTCATGQLSLKVSRFGAFIGCSNYPECSYTRQLARNGDGEGEDAASDGPKVLGTDPATGLEVSLRSGRFGPYVQLGEDAKPRRSSLPRGWSAADLDLARALQLLSLPRDVGAHPEDGKMITAGLGRYGPFVQHDGTYANLGSADEVFSVGLNRAVDLLAEKRSKTGRGRATPAALKELGEHPSAGGPITVRDGRYGPYVNWAKVNATLPKGSDPMAVTLEQAVELIAAKGGGKAAPKKAATKKPAAKKPAAAKKSASRTKAKAGGAAADGTS
(499) DNA topoisomerase 1 [Caulobacter crescentus CB15]
1
MNVVVVESPAKAKTINKYLGSDYTVLASYGHIRDLPSKDGSVEPDNDFAMSWEVDAKASKRVSDIVDAMKKADRLILATDPDREGEAISWHVLEVLNKKKALKDKTVQRVTFNAITKTAVTEAMKAPRDLDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVVDRELEIERFKTQEYWTVDADVSAGSDPFLARLVKHEGKKLTKFDLGNETSALTAKAAVEAAVFKVEAVEKKPGKRSPAPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVSMAPEAIFEARDVIGAVYGKEYVPDSPRMYKSKAKNAQEAHEAIRPTAMGRNPGSLRLEPELGRLYELIWKRTIASQMESARIERTTVDLTSADGQTGLRATGQVVQFPGYLAVYEEGRDDEGDEDSARLPAITEGASAKVLKSRADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASVLGVLRDREYVRMEKQRFIPEDKGRLVTAFLEQFFKRYVEYDFTAALEEKLDLVSDGKLDWKEFLREFWKDFHAAVGEIAELRTTNVLDALNEALGPHIFPDKGDGSNPRLCPTCGSGQLSLKTGKFGAFIGCSNYPECRYTRQLGVSEGDGDAESADKQLGLNPATGLAVWLKNGRFGPYVEELAAEGSSDKPKRSSLPKGWIASAMDMEKALRLLSLPREVGKHPDDGKVITAGLGRFGPFVLHDGTYANLENADEVFDVGLNRAVAILADKRAGGGRPQRGAAAALAELGNHPEDGKPIRVLSGRFGPYIKHGDTNANVPKGKDPAAITLEEALALIAERAAKGGAKKPAKKAAATKSKAKAESDAPAKKTAAKKPAAKKPAAKKAAPKAKAKATAASDDGAAPWDDEG
(1277) DNA topoisomerase 1 [Caulobacter segnis ATCC 21756]
1
MNVVVVESPAKAKTINKYLGSDYTVLASYGHIRDLPSKDGSVEPDNDFAMSWEVDAKASKRVSDIVDALKKADRLILATDPDREGEAISWHVLEVLNKKKALKDKSVQRVTFNAITKTAVTEAMKAPRDLDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVVDREIEIERFKTQEYWTVEADVSAGSDPFLARLVKHEGKKLTKFDLGNETSALAAKAAVQAAVFKVEAVEKKPGKRSPAPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVSMAPEAITEARDVIGKVYGKEYVPDVPRLYKSKAKNAQEAHEAIRPTSMGRNPGSLRLDPELGRLYELIWKRTIASQMESARIERTTVDLESADGKTGLRATGQVVQFPGYLAVYEEGRDDEGDEDSARLPAIVEGSPAQVREARADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASVLGVLRDREYVRMEKQRFIPEDKGRLVTAFLEQFFKRYVEYDFTAALEEQLDLVSDGKLDWKQFLRDFWKDFHAAVGEIAELRTTNVLDALNEALGPHIFPDKGDGSNPRLCPTCGTGQLSLKTGKFGAFIGCSNYPECRYTRQLGVSEGDGEAESADKELGVNPATGRAVWLKNGRFGPYVEELAAEGDKPKRSSLPKGWIASAIDLEKALRLLSLPREVGKHPDDGKVITAGLGRFGPFVLHDGTYANLENADEVFDVGLNRAVAILADKRAGGGRPQRGAAAALAELGNHPEDGKPIRVLSGRFGPYIKHGDTNANVPKGKDPAAITLEEALALIAERAAKGGGKKPAKKAAASKAKAPTKAEGDKPAKKTAAKKPAAKKTAPKAKAKAPAASDDGAAPWDDEA
(1848) DNA topoisomerase 1 [Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]
1
MKLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGSVNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLSPILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQMASAKLERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRADQHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEPWLFPDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYPECKYTRGFGQGEDGVDDNEPVLLGYMPENSDDDGYMAFSDQGDILPANTASASETGVTDGGIAANAAFSGKGNSASHTDRDDLPFDPDEPASSTGNVASSQSRMTGDETASSGNSRDSSAHGVSTTAGIDAESQAGISNQALAGKNNAGRTAVSDNKGNNSSSTIAAARKGGSTDDNATVSDPDGDIGSGASSSGQDADNRLLSHRNGDIDSRAIPADHKDSSSDQNASHALSPDRNSDDASVSNSDKKIDSKAVSTGHDVGNAITSDNSPSDNVAHLASTPSSATSSVKVALETENNDTAASKADEQAKEEEESRKARAVTRRTGRFGPYIQLGEGKNAKRVSVPRDVNPREVDFSLASRLLALPREIGLHPESGKMIIAGTGRYGPYLNCDGKYARLSSTEELLDIDIDRAVVKLAEAAQNKGRTGATLSREPLKVFGDSPVTEKPVQLMNGRYGPYVTDGETNASLPKDTTPESLTFEEALALLEARAKMPKKKKTKKAAAKKPAAKKTTTKKAAPKKATTKTATPKSATTDNATSEDGDATPAKSPAKKAVAKKTTAKKPASKSATKKAPSSKTTAAKKTSKATPKDEVAE
(1847) DNA topoisomerase 1 [Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]
1
MKLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGSVNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLSPILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPTDFSRDKAASGDHARLYELIWKRALASQMASAKLERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRADQHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEPWLFPDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYPECKYTRGFGQGEDGVDDNEPVLLGYMPENSDDDGYMAFSDQGDILPANTASASETGVTDGGIAANAAFSGKGNSASHTDRDDLPFDPDEPASSTGNVASSQSRMTGDETASSGNSRDSSAHGVSTTAGIDAESQAGISNQALAGKNNAGRTAVSDNKGNNSSSTIAAARKGGSTDDNATVSDPDGDIGSGASSSGQDADNRLLSHRNGDIDSRAIPADHKDSSSDQNASHALSPDRNSDDASVSNSDKKIDSKAVSTGHDVGNAITSDNSPSDNVAHLASTPSSATSSVKVALETENNDTAASKADEQAKEEEESRKARAVTRRTGRFGPYIQLGEGKNAKRVSVPRDVNPREVDFSLASRLLALPREIGLHPESGKMIIAGTGRYGPYLNCDGKYARLSSTEELLDIDIDRAVVKLAEAAQNKGRTGATLSREPLKVFGDSPVTEKPVQLMNGRYGPYVTDGETNASLPKDTTPESLTFEEALALLEARAKMPKKKKTKKAAAKKPAAKKTTTKKAAPKKATTKTATPKSATTDNATSEDGDATPAKSPAKKAVAKKTTAKKPASKSATKKAPSSKTTAAKKTSKATPKDEVAE
(566) DNA topoisomerase 1 [Novosphingobium aromaticivorans DSM 12444]
1
MQLVIVESPAKAKTIEKYLGPGYKVLASYGHVRDLPVKDGSVRPDEDFAMDWELYGDKQARVKAISDAAKGADRLILATDPDREGEAISWHVRELLAKRRVLPKEVERVTFNAITKQTVTDAMKKPRALDQDLIDAYLARRALDYLFGFTLSPVLWRKLPGAKSAGRVQSVALRLIVEREREIEAFRAQEYWSVIARLEHAGTEFAARLVKFDGQKLDKLTLGDEGAAMRAKGVVEAATFRVEEVETKPTRRNPYPPFTTSTLQQEAARKLGFSASHTMRVAQTLYEAGAITYMRTDGVQMDPSAISAARKAISDRYDGHYLPEKPRHYETKAKNAQEAHEAIRPTDFSKDRYGSADEARLYDLIYKRAMASQMASANIERTTVTLRDGTGKHELRATGQVVKFPGFLAVYEEGRDQKQDGDEEDGSLLPAMASGDTPAKRGVDATQHFTQPPPRYSEASLVKRLEELGIGRPSTYAATLQVLKDRNYVRTEKNRFFAEESGRLLTAFLERFFPRYVAYEFTAGMEEELDDVSGGRAEWKKVLADFWRDFKPKSDEVMEKKPSEVTAELDEFLSDYLFPPRADGTDPRLCPKCEEGRLSLRGGRYGAFVACSNYPECKYTRKFAQPGGADGDGGEDGALGKDPETGLEVVRKAGRFGPYIQLGDGKEAKRASIPKDIGELDLEWALKLLSLPREVGVHPETGNPITASIGRYGPYLAHDGKYARLKSTAEVFETGMNAAVMLLAAAAAGAGARGSRAAAEPLKVFGAHPTSGGEIKLMAGRYGPYVTDGTTNATLPRDKQPEALTLEEAITLIDERAAKGPAKGKKKAPAKKASAAKKPPAAKKAPAKKAAPKKAAAAE
(1132) DNA topoisomerase III [Azospirillum sp. B510]
3
MATLIITEKSSQAKDLRAALGDRFGRILPAEGHLLRLAEPDEVDPAWKRWSPTLLKPDGLYPTRPDQGGNKAAKLQAITTALRACDEVILATDCDREGQLIGQEILEHVGYRGKVRRALFTAQDPKTLRDAFAALKPNDSMRPLYEAAVARQQADQIYNLSLTRTATKTLLAPGTRGVIGIGRVKTPTLAIVCLRELEIRDFKPEDYFEVVATANVAEGRFLMRHAPAPKDRIKDRATAEAIARAADQHRGPLTVTVEEKRQAPPRLYDLPSLQKTCGQRWGWTADRTLAVAQELYDGDGKKLITYPRAEARYLSENQIGDAPAIVGALTRLRGFAHLGEHMDVRRPVIRKGKSGHFCDKALEGVSHHAVIPNVNVLDDLESRLGRLSDDEKRLFALICRSYLAAVMPDYEYRQTGVTMPVPVPPPEGARTEGAKPVAFRAVGRIPLKLGWKAAFGSAETEDRSGGKPEEEAEQTLPPLRDGEPATLTDPKVEAKRTQAPPRYNEGTLVDAMQNAWRFVEDPALRDRLKEAKGIGTPATRAEVIKGLRKQNLLGADGKWLVPTPAGLHLFETLRAAAPTLVDPGTTALWEMKLDEVVTGRADFRGVIDAIAGEADRLIGALLGQRGTMLDLGQPAAKTRFTRRRTGATRAASAQTGAPAAPKGRRTRKATVVPADGAAMPPKPRRTRKAKEAAVAPPVTGSAVAQPMESQAGPEARRRREPTERMVAFARSLAERKGIALPDPCLRDFERCRSFLDEHAR
(187) DNA topoisomerase 1 [Azospirillum sp. B510]
1
MPGSNVVIVESPAKAKTINKYLGDDYTVIASFGHVRDLPARDGSVRPDEDFAMEWELGDRSKRHIDEIAKAVKSADRIYLATDPDREGEAIAWHLSELLREKHLSDNRDVQRVTFNEITKSAVQTAMANPRAVSQELVDAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICERESEIEVFKPQEYWSIAVGFTTPSGSAFTASLTQLDGKRLDKFGLPNREAAEAAVAKILPRSFAVSSVERKQSRRNPSPPFTTSTLQQEASRKLGFGATRTMRTAQKLYEGVDIGGETVGLITYMRTDGVSLSQEAIDGARGLIGSHYGERYVPDQPRVYKTAAKNAQEAHEAIRPTDLHRRPETVAAYLEQDELRLYELIWKRTLASQMESAVLDQVAVDIASPSDNGAKAVVLRATGSIVVFDGFLKVYQEDRDDAAEDEQQERRLPAMDQGDALARGDIAQDQHFTQPPPRYSEASLVKKLEELGIGRPSTYASILQVLQDRNYVRLDKRRFIPEDRGRLVTAFLENFFHRYVEYNFTAELENQLDEISDGKIDWKTVLRDFWTAFDVAVNGTKDLTITQVLTTLDNELGAHFFPAATEGGHDPRVCPVCREGRLGLKLGKMGAFIGCSRYPDCRYTRPLAVANDENGEAQEGPRELGNDPETGLPVTVRRGPFGAYIQLGPAPAAATPPEEPAAEEPAADGKKPKAKKKKKDEAPKPKRVSLPKGMAAADVDLDTALRLLALPRAIGNHPETGEEISAGIGRFGPYLKHGSVYKSLTADDDVLTIGINRAVDLLAGAAKKASAPAKTLGDHPKTGKPITMGSGRFGPYVKHASVYASIPKGTEPDSVTLEQALELIEAKVAKDAAKKGKAPKDAEPAKAEGAEAEKPAKAKVPAKKPAAKKATKAKAAKDAPAETAAPKKKTVKAS
(1111) DNA topoisomerase 1 [Hyphomonas neptunium ATCC 15444]
1
MKLVVVESPAKAKTINKYLGKDYKVLASYGHIRDLPSKNGSVDPENDFEMVWEADSKSAKRISDIANALKDADTLILATDPDREGEAISWHLVEALRKRRALKKDVAIERVVFNAITKSAVTQAMEHPRAIDAELVDAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRIVCDRENEIESFRAQEYWNIVAELRAPDGTAFEARLHSLDGETLKKFTLGNQGDANRALEIVKVGGYSVVSVEAKPVKRNPPPPFITSTLQQEASRKLGFNAKRTMQAAQKLYEEGRITYMRTDGVNMAEEAYVAARTMIQSNYGARYLPENTRRYSSKAKNAQEAHEAIRPTDFNLRPEDYHGDGDLKKLYTLVWRRAVASQMETALFERTTIDLASKDKRAGLRATGQVLVFDGFIKLYTEGHDAGDDDDDAEGRLPKMAEGQHADLLKADANQSFTQPPPRYTEASLVKRLEELGIGRPSTYASTMSTLEDRGYVRIEGKALVPEDKGRLVTAFLENFFSRYVEYDFTAGLEEKLDVISDGKLDWKAFLREFWQQFAADIDGTKDLRVSAVLDALNEALGAYVFPRQDAEGNPIENPRQCPLCKEGELSMKLGKFGAFVGCSRHPECKYTRQFSSEGGDAAINPDGNEIGIHPDTGAMILLKSGRFGPYVEMANGEKPKRASLAKADNAAELTLERAVELLSLPREVGPHPEDGEMILANFGRFGPYVQHGKTYANLKDPRDVFTIGVNHAVSLIEDKKARGSARGGAAALKALGDHPDGGAIEVFEGRYGPYVKWGKVNATLPKEITPDVVTLEQAIELVNAKGGSAKKKAPAKKAAAKKPAAKKAAPKKKAPAKKAEE
(1028) DNA topoisomerase 1 [Hirschia baltica ATCC 49814]
1
MQVVVVESPAKAKTINNYLGKDYIVLASYGHIRDLPSKDGSVDPDADFAMKWEGDSKSNKRIKDIADALKGADGLILATDPDREGEAISWHVLDVLSKKRGLMKDKKIERVVFNAITKKSILEAMQNPRSLDQELVDAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRLICEREVEIEAFKPEEYWTIKGLMDSVSKTEFEARLYELEGKKTQKFSFPNKEAADKALEVVRVGGYTVQSVEAKPVKSNPPPPFTTSTLQQEASRKLGFNASRTMGAAQKLYEAGLITYMRTDGVEMAQEAIHAARDAIKERYGAPYVPSSPRIYTSKAKNAQEAHEAVRPTDFLKHPSEVRLEADLQRLYDLVWKRAVASQMATAQLERTTADLKSKDGQAILRATGQVVKFDGFLTLYQEGKDDANGDEDAKRLPAMSVGDVIDLKKADANQSFTQPPPRFTEASLVKKMEELGIGRPSTYASTLATLRDRDYVEMDKNRFVPADKGRLVTIFLENYFNQYVQYDFTAELEEKLDLVSDGKLEWKVFLAEFWKQFSLKIAEVMELRVTNVLDLLNDVLGPKIFPPKLDEKTGEPTGEDPRLCPLCKEGQLSMKLGRNGAFIGCSNYPECKHTRPFTTDGSDAEDAVSPDGKLLGQDPETGKDISLRTGRFGPYVQLGEGIGKEKPKRGSIPKGWKADELTLAQAIQLINLPREIGPHPEDGEMMYANFGRYGPYVQHQKTYANLPDPMDVFEVGLNRAVALIAEKNAKGGRGGAAKALKELGKHPDTDEPINVFDGRYGPYVKHQKTNATLPKDLTPETITLEKAIELINAKAGASKKKAPAKKKAPAKKTAAKKAPAKKAPASDS
(1756) DNA topoisomerase 1 [Parvularcula bermudensis HTCC2503]
1
MQVVIVESPSKAKTINKYLGSDYKVLASYGHIRDLPSKNGSVDPEADFSMIWESDARSKKHVSDIVDAVKAADGVILATDPDREGEAISWHLLEVLDKKKALKDKSIQRVAFNAITKRAVEEAIANPRTIDQDLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLICERELEIEKFIAEEFWTLEANVSADDSPQFAARLVKLDGTKVEKFTLTTEEDGSRAKKAVEDAQFLIKSVEAKPTRRNPAAPFTTSTLQQEASRKLGFNARRTMQTAQRLYEGITIGGETTGLITYMRTDGIDMAPEAVMAVRDEIKSTFGADYLPSSPRMYKSKQKNAQEAHECIRPTNFARHPDALKQLDQDQYRLYDLIWKRAMACQMETARLEQTTIDIESRDGKTGLRATGSVVVFDGFLKLYAEGRDDTEDEKDRSLPKVSEGSDAQVTDPTPEQHFTQPPPRFTEASLVKRLEELGIGRPSTYASIISTLQDRSYVTMDKNRFIPDDKGRIVTAFLENFFGRYVEYDFTAKLEETLDDISNGEMAWKAFLRRFWDEFHARVEDMSDLRISEVLDALNEALGPHIFPQREDGRPPRECPTCGEGELSLKVGRYGAFIGCSRYPECKHTRPLGQSEQGNAPAEDRQLGVDPDTSQAVWLKSGRFGPYVQLGEPDPDTKEKPKRSSIPKSWDAASLDFDKAMKLLALPRDVGPHPEDGEMIEASLGRYGPYVKHGKLYANLESIDDVFDIGINRAVAVLEDKKANPRGRGRSAAKPQRELGNHPDTDELVAVYDGRYGPYVKHQKTNATIPQGVDPAEITLEQALELISAREAKKPTKKKKTAKKKSAKKPAKKKTTKKAAKKATKKTTNSAGKD
(1811) DNA topoisomerase 1 [Magnetococcus marinus MC-1]
1
MTAVVIVESPAKAKTINKFLGRGYKVVATYGHIRDLPSKNGSVDTEHGFAMKYSVPKDSTKRVDELAKAVKGAEQVLLATDPDREGEAISWHVYEVLNEKKLLENVQVKRVVFHEITKTAIQDAVAHARDVDMDMVNAQQARRALDYLVGFNLSPLLWRKVRRGLSAGRVQSVALRLVCEREAEIQAFEAREYWSITALAAQAAQSAPRPFEARLAVADGEKLSKFSIGDEAYAKRLIKAVEKRPLYVSEIEKKQSKRNPAPPFITSTLQQEASRKLGFSAKKTMTVAQRLYEGMEVPTADGGKETVGLISYMRTDSVNLANEAIESIRKQIEIRYGKEYLPKSPRKYKSSAKNAQEAHEAIRPTDVIRTPEMLREILEKDQFRLYELIWKRTVACQMAQAKIDKVAANLSVDSQDPNAAYRFRATGSSVAFAGFMKVYMEGKDEVSAQDREDDDDDNESILPPLEVGQQLEQKSLDARQHFTEPPPRYTEATLVKVLESYGIGRPSTYAPTMSTLQDRGYVKLDARKFYPEDVGMVVNSYLTKHFSTYVDYNFTANLEDQLDAVSRGEKSWVPLMEDFWQPFIQQITLKDETTSKEEVTTEQIDEPCPKCGAPLSIKLGRFGKFKACTGYPECKHTEPLNKEEEVSRPEPELTDIPCDKCGKPMLIKEGRYGKYYGCSGAPECKNNQPLNKPRDTGVACPSCGQGTFLEKKSRRGKIFYSCSNYPKCKQALWDEPLEIPCPKCQAPFVTKKVTKTRGTEHICVAEGCDYKEVVEAPIKTSKQ
(654) DNA topoisomerase [Magnetococcus marinus MC-1]
4
MILYLCEKPSQGRDIGRVLGATSRHEGYVAGAGVCVTWCIGHLMEMVAPDGYRPEWKSWRLDTLPIIPQQWQLELTARGRKQFKVIQGLLKGVTEVVLATDADREGETIGREVLERCQYRGKISRLWLSALDDASIRKALGNLLPGEQTEPLYQAGLGRSRADWMVGMNLTRAYTLLGRQGGYAGVLSVGRVQTPTLKLVVDRDRLIENFKPVDYFEIFALHRVHSGTFIAKWVPPPKPCDAEGHCLDRTLAETVIHKVQGHSGTITKAETKRVKEPPPLPLELSTLQQEASRRWGMGAKQTLEIAQSLYEKHKAVTYPRTDCRYLPSNQFKEAPAVLQGLTTNDASLTPLVEGADAQLRSKAWNDKKITAHHAIIPTAAKINIDALSREEALLYDLIRRHYLAQFYPPFEYDRTVIDTQVAMETFHATGRVELIPGWKRVLAANQEKKEGDEDEQTLPVVRSGEAATIEGAELKQKQTKPPNRYTEGTLIQAMKSVGKLVEDARLRKILRETSGIGTEATRAAILETLIKRNLLAKQGKKSLVSMPAGRLLVDALPHSVTDPATTAVWEQTLDDIAHGGGSLETFLAKSELWLNKLIHNVHQRQQLGLNPFRGLPPSTSHTDPAQPTPRRQRRSKAEVTPTPNAAPLCPQCGGPMLQRKSPQGAFWSCAEQATCTGTRPGSPLAAHSPLMQPNPERGPLCPKCQQAPLVQRTAYRGKNSGQPFWGCQRYPQCRYTQASQTTES
(121) DNA topoisomerase 1 [Maricaulis maris MCS10]
1
MNVVVVESPAKAKTINKYLGADYTVLASFGHVRDLPAKDGSVKPDEDFEMAWEIDTASAKRVKAIADAVRESDRLILATDPDREGEAISWHLLEALQKRRVLKDVTVQRVAFNAITKPAILEAMAHPRAVDMELVNAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICDRELEIEKFRSEEYWTVDADLTANSDSFRAKLVTLGGKKLQKLSIKDRASANAAVEAVNSANLSITGVEAKPAKRNPPPPFTTSTLQQEAARKLGFSATRTMQTAQKLYEGVTLGGETTGLITYMRTDGVTMVPEAVSQARDVIGKEHGSLYVPSAPRHYASKAKNAQEAHEAIRPTSFSRLPEKLSLDADMARLYQLIWRRAVASQMESARFERTTVDIASPDGQTALRAVGTVQLFDGFLALYQEGRDDEEDEGENRLPKLTQGAAATVAKTHADQHFTQPPPRFTEASLVKRMEELGIGRPSTYASTLQVLRDREYVQMEKNRFHPFDKGRVVIAFLENFFARYVEYDFTASLETQLDKVSAGELDWKQLLRDFWTDFRAAIDEIGELRITNVLDALNEALAPHIFPEKEDGTDPRLCPSCKEGTLSLRLGKFGAFLGCSNHPDCSFTRQMSPPGEDDAQGDRVIVQHPETGKDVELKNGRFGWYLQMQLDGEDKPKRSSIPKGWDAATLTEEQAIKLIDLPRTVGEHPDDGQPITANIGRYGPYVHHDKTYANIPSVEEVFEIGLNRAVSVIADKRANGGRRGATASALKELGEHDGKPVRIMSGRYGPYVKYEKINATLPKDTDPESVTLEQAMEWVEAKAAKGGKKKAPAKKKAPAKKKAPAKKATAKKPAAKKTAAAKDKAE
(700) DNA topoisomerase 1 [Granulibacter bethesdensis CGDNIH1]
1
MPHDVAIIGILMTDVVVVESPAKAKTINKYLGGNYTVLASFGHVRDLPPKDGSVRPDQDFAMDWEADERGRKQVAAIAKALKGAETLYLATDPDREGEAISWHVRAMLEEARALKGVEVRRITFNEITRNAIRHAIEHPRDLDQPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFRPREYWTVETHFFTPAGAPFTARLTHLDGKKLDQFDLNTEALAMRARALVEQGQFHVGMIERKKVKRNPPPPFTTSTLQQESSRKLGFGAQATMRLAQQLYEGVEIGGETVGLITYMRTDGVQMAREAMFSIRDHVKDSYGLDYLPAAPREYSSKAKNAQEAHEAIRPTDVERTPDSVARYLNPEQRRLYELVWKRAVASQMQSAELDQVTVDIFPQTGDAKSVQLRATGSIIAFDGFLKLYREGQDDTEEEEGRMLPPMAERDPLRQDRVDASQHFTQPPPRYSEASLVKRMEELGIGRPSTYASILSVLQDRNYVRLDKRRFHPEDRGRLVTAFLTSFFERYVDTNFTASLETQLDEISDGRADWRQVMQAFWQDFYQAVEQTKDLKISDVIDALDRDLGPHFFPTREDGTDPRICPACGDGRLGLRLGRHGSFIGCSNYPGCSYTRRLGIDGAEGEAETLKEGMRVLGQHPETGEDITVKRGPYGLYVQQGEAEEGSKKKPRRASLPRGVDGETILLDQALGLLSLPRLVGIHPETGEPIEANLGRFGPYVKMGGIYGNLDKDDDVLTVGLNRAVDVLAKKMASIRTLGTHPKDKEPVVVRKGRFGPYVQHGQVVANVPREIEMDDVTLDDALGWLAEKGKPLKAKGGRKVAAKSSGKKAASADGNEAQPLKKATAKKTTRAAGAGKAAAKKSGTRSATAKTAKAER
(1149) DNA topoisomerase 1 [Xanthobacter autotrophicus Py2]
1
MQVVIVESPAKAKTINKYLGPGYEVIASYGHVRDLPSKDGSVDPDADFRMLWEVDPKAQKRLNEIATAVKGADGLILATDPDREGEAISWHVLEVLKQKKALKDQKVERVVFNAITKQAVLDAMKAPRAIDVALVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREREIETFVQKEYWSILARLATPRAEEFEARLTGADGKKITRLSVGTAEEAKAFRAALEAADFRVRSVEAKPMRRHPQPPFTTSTLQQEASRKLGLAPARTMQIAQRLYEGVDVGGETVGLITYMRTDGVDMAPEAVAATRSAIGKQFGPKYLPGVPRKYTTKAKNAQEAHEAIRPTDPSRHPREVARHLDGEQAKLYELIWIRTVASQMESAELERTTADIEAKAGGRTLDLTATGTVVKFDGFLTLYREGKDDEDDDEESRRLPAMSANEKLNRRDILTTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLAVLRDREYVKLEKKRLVPEDKGRLVTAFLESFFKRYVEYDFTADLEEKLDEVSAAELDWKEVLRAFWQDFHTAVEATKDLRVSQVLDALDEMLTAHIFPPTQDGSDPRLCPTCGNGRLSLKMGKFGAFIGCSNYPECRHTRPLTGDGAPEGDGKRELGIDPESGEDVTIRAGRFGTYLQLGEGKDGEKPKRSSLPKGLAPADVDLETALKLLALPREVGKHPEDGEPILAGIGRYGPYVQHGRTYANIEDGDDILAIGLNRAVVLIAEKQSKGRGGRGAATPGRTLGDHPTLGGPVTVRPGRFGPYVNHGKVNATLPKSVDPEALTLAEAVTLIDAKAALSPSKAKAPRKAATKAAASGEDAPAKAATKTAAKKPAAKSAAKKTATKQPAAKKTTKTASKGPKAAE
(140) DNA topoisomerase [Methylobacterium sp. 4-46]
3
MFFFEKPSAMRELQRFFRAPTTVCIAAEGHLLAAQEPAEIRPAWKAWRFEDLPIAVDEIPLCCGQSRSGASHAARIAAIRRALDGVERVIIATDPGREGSMIAWEVLEHLGYRGRVDRLRLGALDEVSIRRAFAALGRDPDSGERDYAAYQEALCRRYEDWHLGLNGTRAVSLRLRPAAFREPWRFGGVQTPTLALLADLERRIRDFVPREFFRIALPVATVSGAELTLWHAPKERIFAREEAEAIAAAARGWAGPLAVAERDVRRPPPRLFSKDTLARRCAKSFGFDPQRTASLAQDLYDRGFLSYPRTESEHLPESQSGDAPAVLAALGASLPDLAGLVPAPGAVVLRRGPRGHYVKDPGEHHAIVPLRKVPRPGEVGPEAWRLWELVAKAFLAAHLPDGIDARTTVSAEVATALGPKRFAVTGSVVRAPGWRAVYGAEAEDEEPVPGKAKREDEPSAGRLPPVAPGEAARAGEARVEGAMTEPPRRITRGELPVVMGRLIDQVEDPALKRALENPANPNEPRGLGTAATRDAVLPKLEKSGYVVLGGALPADARAGAGGNAPRRRRDTPGRADRGGGGARGRDPTITVTEAGLAFIDAVRRVFPAYGDPVGRAVFEADLAEIGRAATRAEAVSRAETFRQRTRARLDALIAAVAGLERAAVEGPAAAPAGRPPSDAMVAFATALAARKNLPLPRGVARDAAVCRRFLDAHAEKREPTAPGAPRPPTPAMLRYAESLAREAGLPDLPEEARTEFAACRAFLDAHARPAPAEARERAGPRRPGAGRPRRRPARSPRARTAGTALGEPA
(167) DNA topoisomerase 1 [Methylobacterium sp. 4-46]
1
MKVVVVESPAKAKTINKYLGHDYEVLASFGHVRDLPAKDGSVDPEQDFKMLWELEERGAKRVSEIARAVKGADTLILATDPDREGEAISWHVLEALQAKRVLKDVAVERVTFNAITKDAVQTAMANPRQIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIEAFKPREYWSLVATLATAKGATFEARLVGADGKRIQRLDVGTAEEAEAFRRDLELATFAVASVESKPAKRHPQPPFTTSTLQQEASRKLGLAPAQTMRIAQRLYEGVEIGGETVGLITYMRTDGVDMAPEAIRDARRVIGAEFGDAYLPGAPRSYSVKAKNAQEAHEAVRPTDLGRLPKEVARFLEPEQAKLYELIWIRTIASQMESAELERTVVEIAAQVGPRRLDLRATGQVVRFDGFLTLYQEGKDDEEDEESRRLPPMQAGDPLRRERVAATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQVLRDREYVRLDKKRLVPEDKGRLVTGFLESFFQRYVEYDFTADLEEQLDRISNAEIDWREVLRDFWRDFSAALAGTKELRTAEVLEALNQLLGPHIFPPRADGANPRACPNCAGGTLSLKLGKFGAFVGCSNYPECKYTRQLSAAGLDGDGEGSAGEGGQPGVRVLGEDPATGLPVTLRDGRFGPFVQLGEASAEKGAEKPKRSSLPRGLTPADVTLETALKLLALPREVARHPESGEPILVNLGRFGPYVQHGKTYANLGKDDDLLEIGANRAIDLIVAKEQGGGRPAADPGRVLGNDPEGRAVTVKAGRYGPYVTDGEVNATLPKGADKEALTLEEALRLIVARREAGGGTKKKTSGRARAARKTEAKPAAKAKAEKAAKPAAAGKSASAGKSASAAKSATAPEKAPARKKAAAAE
(1512) DNA topoisomerase 1 [Methylobacterium radiotolerans JCM 2831]
1
MKVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDGSVDPEQDFRMVWELADRGASRVSEIAKAVKGADKLILATDPDREGEAISWHVLEALTARKALKGIPVERVTFNAITKASVEQAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEARLVGADGKRIQRLDVGTGEEAAAFRRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDARRVIGKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIWTRTMASQMESAELERTTVDVTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLEEQLDRVSNAEIDWRAVLRDFWRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGSNPRTCPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSATGIDGDGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFLQLGEASTEKGAEKPKRSSLPKGLSPSDVDLNKALALLALPREVARHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRLAADPGRPLGKDEASGRDLVVKAGKYGPYVTDGEVNATLPKTMSAEALTLDEAIALVNAKRAAGGGKPAKRGAARKSSARAASGDKPAAKKTATKKPAAKKAATKKSSSG
(300) DNA topoisomerase 1 [Rhodospirillum centenum SW]
1
MPGHNVVIVESPAKAKTINKYLGQDFTVLASYGHVRDLPPRDGSVRPDEDFEMDWELGDRSKRHIDEIARAVRGADRVYLATDPDREGEAIAWHMKEVLGERRLLGKVDVKRITFNEITKSAVQTALAQPRDVNRELVDAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLVCEREAEIEVFRPQEYWTIEADFRTQEGQTFTARLSQLDGKRLEKFTLGTQGDADAAVARIRPMTFRVGRIERKEVRRNPFPPFTTSTLQQEASRKLGFGATKTMRTAQRLYEGVDIGGETVGLITYMRTDGVALSQEAIDAARRLIDESWGRSYVPEKPRIYKAAAKNAQEAHEAIRPTDLFRRPEHVARYLEKDELALYELIWKRTLASQMASAVLDQVTVDIISKGAEAVFRATGSVIRFDGFLKVYQEDKDDADEDEDHRRLPPMRDGDDLARGEIRPNQHFTQPPPRYSEASLVKKLEELGIGRPSTYASILQVLQDREYVRLEKRRFIPEDRGRLVTAFLESFFPRYVEYTFTADLEGKLDDISGGRIDWKQVLREFWRQFSAAVEDTRDLTITQVLTALDELLGPHFFPRRLGPDGQEVDARVCPTCGTGRLSLKLGKSGGFIGCSNYPECRYTRPLSVAGEGGEAESGDRMLGNDPETSLPVWVKTGRFGAYVQLGNGDGKEEKPKRASLPRGMLPATMDLDTALRLLALPRSLGTHPESGLEIVAGIGRYGPYLKHGASYKNLTAEDDVLTIGLNRAVVVLGDAPAKKAVAGRELGAHPKDGKPVKVGSGRFGPYVQHNKLFASIPKSMSADTVTLAEALELLAAKAAKDGAKKGPAKAEGGEEAAATPAKKTTAKKAPAKKAPAKKTGAAKAESAGTDAEAETAEKPARRTAAKTTKAPAKASAAKASGTKAATRKAAAGD
(1832) DNA topoisomerase 1 [Gluconobacter oxydans 621H]
1
MTDVVVVESPAKAKTINKYLGSGYTVLASFGHVRDLPPKDGSVRPDENFAMSWQTDERGAKQISAITKALKGAKNLYLATDPDREGEAISWHVRSVLEEKKLLKNVDVHRVTFNEITKSAVTAAMAAPRELDRPLIDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFRPKEYWTVTGGFTTPGKAAFQARLTHLKSEKLDQFDLNNEQLAFGARDTVLGGQFTVRSVERKRTKRNPPPPFTTSTLQQEASRKLGMSAQTTMRTAQQLYEGVDLRGETTGLITYMRTDGVTMAKEAIGSIRGHIGKAFGDEYVPDYPRSYSTKAKNAQEAHEAIRPTDVFLTPQQVAHALTPEQKKLYELIWKRSVASQMQSAELDQVAVTLADASGQTLLRATGSTIAFDGFLKLYIEGRDDTKAEDEDGKLLPPMKEGDRLTTGAVEAEQHFTQPPPRYSEASLVKKMEEIGIGRPSTYASILGVLRDRNYVRLDARRFVPEDRGRLVTAFLTSFFERYVDTGFTASLEEQLDDISGGRADWHDVMAAFWHDFSAAVAQTKDLKISDVIDALDEDLGPHFFPPRPDGADPRVCTSCGTGRLGLRLGKFGAFIGCSNYPTCQFTRRLVAEEGDTEGLNDGPKVLGQDPETGEDVTIRRGPYGLYIQRGEPNPEDKKAKPKRTTIPKGLDGNTMTLEQALGLLSLPRLVGLHPETGEKIEAGLGRFGPYVKMGAIYGTLDKDDDVLTVGLNRAVDALAKKLASIRNLGPHPKDGEPVMIRKGRFGPYAQHGQLIANLPKGQDMDEVTLDEAVALLAEKGKPLKGGAKKTSAKKAAPKAAKAKKNVAAAEGDETAPKKVTKRSPAKSATKTKTTTPRKRKTVSDTSSEG
(498) DNA topoisomerase 1 [Acidiphilium multivorum AIU301]
1
MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGDRQVAAIAKALKGADTLYLATDPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEVTKSAVQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICEREAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVERGAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVGLITYMRTDGVQMAREAITAARQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFTLTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTVELADAAGTTLRATGSILAFDGFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEELGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEEKLDEVSDGRLDWRSVMRDFWADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDPRVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEGGEDEGDQLRDGMKLLGENAEGIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGVHPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHPKDGESVTARKGRFGPYVQHGKTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAKPAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPKAAAAKAKPAARKTARSGG
(70) DNA topoisomerase 1 [Methylobacterium nodulans ORS 2060]
1
MKVVVVESPAKAKTINKYLGHGYEVLASFGHVRDLPAKDGSVDPEQDFKMLWELEDRGAKRVSEIARAVKGADKLILATDPDREGEAISWHVLEALQAKRVLKDVSVERVTFNAITKDAVQTAMAQPRQIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIEAFRPREFWSLVATLATARGAVFDARLVGADGKRIQRLDIGTAEEAEAFRRDLELATFTVGNVEAKPARRHPQPPFTTSTLQQEASRKLGLAPAQTMRIAQRLYEGVEIGGETVGLITYMRTDGVDMAPEAIQDARRVIGAEFGDAYVPAAPRSYSVKAKNAQEAHEAVRPTDLGRLPKEVARFLEPEQARLYELIWIRTVASQMESAELERTTVDIAAQVGPRRLDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPSMAAGEALRRERIAATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQVLRDREYVRLDKKRLVPEDKGRLVTGFLESFFRRYVEYDFTADLEEQLDRISNAEIDWRAVLRDFWRDFSAAIAGTKELRTAEVLEALNQLLGPHIFPPRADGANPRACPNCASGTLSLKLGKFGAFVGCSNYPECKYTRQLSAAGVEGEGDGSSGEGGQPGQRVLGEDPATGLPVTLREGRFGPFVQLGEASAEKGAEKPKRSSLPRGLSPAEVSLETALKLLALPREVARHPETGEPILVNLGRFGPYVQHGKTYANLGKGDDLLEIGANRAIDLIVAKEQGGGRPAADPGRVLGNDPESGRAVTVKAGRYGPYVTDGEVNATLPKGADRDAITLDEALRLIAARREAGGGTKKKATTRTRKSETAAKPAGKATKKAPTKASAAKKKAAAE
(1787) DNA topoisomerase [Methylobacterium nodulans ORS 2060]
3
MARASADRTLFFFEKPSAMRQLQRFFKAPTTICVSAEGHLLAAQEPAAIRPAWKAWRFDDLPIALDEIPVAYARNRSGASHAGRIEAIRGALQGVDRVIIATDPGREGSMIAWEVLEHLGYRGRVERLRLGALDEVSIRRAFAALAREPDSGERDYAAYLEALCRRYEDWHLGLNGTRAVSLRLRPPAFREPWRFGGVQTPTLAILADLERRIRDFVPRDFFKVAMPVETETGAALTLWHAPKERIFDRAEADAIREAAAGWSGPLSVVQKDVRRPPPRLFSKDTLARRCAKRFGWDPQRTAATAQDLYDSGFLSYPRTESEHLPESQSGDAAAILAAIAGCLDDVAELVPAGEAIVVRRGPRGHYVKDPGEHHAIVPLRKVPRRGELGPEAWRLWELVAKSYLAAHLPDGIDARTTVAAEVATPPGPKRFAVTGSVVRAPGWRAVYGSEAEDEDPVPGKARRDDEPTTGRLPPLRDGAAARATDATVETAVTEPPRRITRGELPVVMGRLIDQVEDPVLRRALENPANPNEPRGLGTAATRDAVLPKLEKSHYVVLAKGKDPAITVTEAGLAFIDAVRRVFPAYGDPVGRAVFEADLAEIGRAPSRAEAVRRAEEFRQRTRARLDALIAAVAGSERLAVAAPSPDGAGRPPTPAMVAFATALAARKGLRLPRGLKQDAAICRRFLDAHAEQREAAAPGAPRPPTPAMRRYAEALARENGLDKLPDDAATDFSACRRFLDAHAAPRPDAPAKPSPRKPAPRRRTRPPAGADRHADTSN
(798) DNA topoisomerase 1 [Methylobacterium populi BJ001]
1
MKVVVVESPAKAKTINKYLGRDYEVLASFGHIRDLPAKDGSVDPEADFAMVWELEDRGSKRVSEIARAIKGAEKLILATDPDREGEAISWHVIEALSARKALKGIPVERVTFNAITKASVDAAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWSIVATLATEAGGVFEARLVGADGKRIQRLDVGNAEEAAAFKRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQKLYEGVDVGGETVGIITYMRTDGVDMAPEAISDARRVIGREFGDDYVPGAPRKYSVKAKNAQEAHEAVRPTDMGRLPKQVARYLEPEQAKLYELIWTRTIASQMESAELERTTVEVTASVGPRRIDLRATGQVVKFDGFLALYQEGKDDEEDEDSKRLPAMAAGDPLKRERIASTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFKRYVEYDFTASLEEQLDRVSNAEIDWRSVLRDFWRDFSAAIGGTKELRVAEVLEALNGLLGPHIFPEKADGGDPRACPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSASGVEGEGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFVQLGEASSEKGAEKPKRSSLPKGTSPGSVTLEIALRLLSLPREVAKHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRPSSDPGRALGPHPDGAALVVKAGKYGPYVSDGSVNATLPKTMAAESLTLEQAIELINAKRASGGGKKPVRKTATRARTATKAADGAEAKKPAVRKTASKTASKSTTKAAAKPAAAKKAAAKTKAS
(1752) DNA topoisomerase 1 [Ketogulonicigenium vulgare WSH-001]
1
MPVVVVESPAKAKTINKYLGSDYQVLASYGHVRDLPPKDGSVDTDEDFAMTWEVDANSKKHIKAIADALKADPNLILATDPDREGEAISWHLVEALTDRKAIKKDTPVSRVVFNAITKSAVTEAMQNPRQVDAPLVEAYLARRALDYLVGFKLSPVLWRKLPGAKSAGRVQSVCLRVIVDREVEIEAFRAQEYWTVAAEIETPRGQIFTARLVTLGGKKLDKFDLGNQVAAEMAVQAVTSRALSVQGVEAKPAQRHPSAPFMTSTLQQEASRKFGMGAKATMSAAQRLYEAGLITYMRTDGIDMAPEAVMAARDAIRDKFGADYLPASPRMYKNKAKNAQEAHECIRPTDMTRGVEQQKIVDADQRKLYDLIYKRTIASQMAAARLERTTVDIGAADGQVGLRATGQVVLFDGFLAIYEEGRDDSTDEDEGRLPQMMQGEALKKLAVTPDQHFTQPPPRYTEATLVKRMEELGIGRPSTYASIVTTIQDRGYVQKDKNRLIPQDKGRLVTAFLENYFPRYVEYDFTAGLEDQLDKVSAGDADYKDVLRQFWRDFSAALNETSELRITDVLEKLNEVLSPIMFPPKPDGSDPRACPNCGNGHLSMRTARSGGAFIGCSNYPECRFTRPFGPPELAEGAIGPDGRLLGHDEGDPITLRDGRFGPYVQRGEATEEVPKPPRASLPKTWSPDEVTLERAVSLLNLPRPVGPHPEDGVLIEAGLGRFGPFIKHGSTYANLKSIDEVFEIGMNHAVELLAQKLAGGRGRTAVAKPLKELGDHPDGGAITVMPGRYGPYVKWEKVNATIPKDIEPEALTIEQALELITAKAGKKPAKKPAKKAATAKAATTKAKAAPKAKTTKAKAASADPAKPKRKTAKAAPDVVEDEA
(36) DNA topoisomerase 1 [Ruegeria sp. TM1040]
1
MPVVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPAKNGSVDPEDDFAMTWEVGNDSKKHVRAIAEALKDDNALILATDPDREGEAISWHLQEALTKRRSIKKDTDVKRVTFNAITKDAVAEAMKNPRDVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVCLRLIVEREMEIEAFNPQEYWSVRANLATPRGQSFEARLTVLGGEKLDKFSLANSTAAELAVQAVSSRKMSVLSVEAKPAARNPSAPFMTSTLQQEASRKFGMGAKQCMNAAQRLYEAGLITYMRTDGIDMAPEAVSAARDEIAKRYGQEYVPGEPRIYKNKAKNAQEAHECIRPTDMSRDAASLKVSEDDQRKLYDLIWKRTLACQMAGARLERTTVDIGSDDKQVVLRATGQVVMFDGFMRVYEEGRDDVVDEDDKRLPQIMQGEALKFAGSLAAQAEKAGKDGSVLSQDGATLALQHHTQPPPRYTEATLVKRMEELGIGRPSTYASVITTIQDREYVRKDKNRLFPEDKGRIVTIFLLNFFKRYVEYDFTAALENQLDDVSAGGKDYKELLDSFWRDFSAAISETSDLRISEVLDVLDEALAPQLYPPREDGGDPRICPKCGAGQLHLKTSRTGGFVGCGNYPECNYTRPISGEGAEGYERVLGEDDGDEIHLKSGRFGPYVQRGEATPENKKPPRSSLPKQGKDYLPGWGPNEITLEQAVTLLTLPREIGAHPEGGVVSSNLGRFGPYIMHQRPDEEKPVYVNLKETLDVFEIGMNRAVEMLAEKRANPGRGRSAAAKPLRELGEHPDDKAPVNIMDGRYGPYVKWGKVNATLPKDTEAKDVTMEMAVELLNEKAAKSGKKKAPAKKAAAKKTTAKKTTAKKAPAKKKEAKASGD
(619) DNA topoisomerase 1 [Sphingobium chlorophenolicum L-1]
1
MQLVIVESPAKAKTIEKYLGGDFHVLASYGHIRDLPAKDGSVDPDAGFAMQWENYGDKGKQLKAIADEAKKATRLILATDPDREGEAISWHVQEVLRAKKALPQKVDRVTFNAITKQAVTEAMAQPRALDEDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIESFVPQEYWSVAAEMEQGGQGFTARLVRWRGEKIERLTIGREGDAMAAKADVEAGRFTVEKVETKPVSRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQQLYEDGAITYMRTDGVQMDGSAISAARKAIAERYDGGYLPEKPRQYQTKAKNAQEAHEAIRPTEFYRDKVGSGDHARLYDLIFKRALASQMASARLERTTIDLVDGTGQHGLRATGQVVIFPGFLALYEEGRDDTEDDDSKLLPRMAEGDAPAKKKVTAEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASTLQVLKDRDYVRIEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEEELDDISGGRAQWQAVLEAFWRDFKPKTTEVMEQKPSDITAELDKFLEPMLFPPKADGSNPRACPMCGDGQLSLRGGRFGAFIACSNYPECKYTRKFGQPGGKDGAEDSGPEVLGKHPETGQDIVRKSGRFGPYIEMGEGKEAKRGSIPKDLPDGEMTLDWAVKLLSLPREIGLHPETGKPIVANIGRFGPYLLHDGKYGRLSSTAEIFEVGMNSAVAKLADAANRGGRGASSREPLKVLGKHPRTEAEIKLMAGRYGPYVTDGTTNATLPKTIEQDALTLEEAAQLIDARAAAAPAKKGKKAPAKKAAAKKPAAKKAPAKKKVAAE
(680) DNA topoisomerase 1 [Phenylobacterium zucineum HLK1]
1
MNVVIVESPAKAKTINKYLGSDYKVLASYGHVRDLPAKDGSVRPDEDFAMSWDVDAKAAKRLSEIAEAAKGADRVILATDPDREGEAISWHVLEVLQKKRALKDAKVQRVVFNAITKSAVTEAMANPRELDMELVEAYLARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDRELEIERFRTQEYWTVEAEVAAGGDPFTARLVKHEGKRLSKFDLGNEASAFAARDAVKAATFKVAAVERKPGRRSPPPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLITYMRTDGVQTAPEALDEARAVIGGLYGKDYVPEKPRFYSTKAKNAQEAHEAIRPTSLGRNPGKLRLEGDLGRLYELIWKRMIASQMESARIERTTIDLESADGRTGLRATGQVVTFPGYLAVYEEGRDDPEDEEGGRLPQVAEGAQATVRQAKADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASILERLRDRSYVRMEKQRFVPEDQGRIVTIFLEEFFGKYVEYDFTADLEDQLDQVSAGDLDWKVLLKNFWADFNAKVGELGQIGTREVIDALDESLASTLFPPMADGSDPRVCPRCGSGRLSLKPSRTGAFIGCSNYPECRFTRPFGPPDAEGAEASGDRDLGTDPQTGETVWLKAGRFGPYVQLGEGEKPKRSSLPKGWSVADMDLEKALRLLRLPREIGPHPEDGKPILAGIGRYGPFVQHNGTYANLPSVDEVFEVGLNRAVDLIATKRAGGKRGGEAEALKDLGAHPADGQPVRVLAGRYGPYVKHGSTNATIPKGADPKALTLDEAVKLLAEREAKGGGKKKPARKAKAEPKAKKAPAKKAPAKKAAAKTPAKATPAGDIDDDESPF
(1109) DNA topoisomerase III [Azospirillum lipoferum 4B]
3
MATLIITEKSSQAKDLRAALGDRYGRILPAEGHLLRLAEPDEVDPAWKRWSPTLLKPDGLYPTRPDQGGNKAAKLQAITAALRACDEVILATDCDREGQLIGQEILEHVGYRGKVRRALFTAQDPKTLRDAFSALKPNDSMRPLYEAAVARQQADQIYNLSLTRTATKTLLAPGTRGVIGIGRVKTPTLAIVCLRELEIRNFKPEDYFEVVATASVAEGSFQMRHAPAPKDRIKDRATAEAIARAADNHRGPLTVTVEEKRQVPPKLYDLPALQKTCGQRWGWTADRTLAVAQELYDGDGKKLITYPRAEARYLSENQIADVPAIVGALTRLRGFAHLDIARPVIRKGKSGHFCDKALEGVSHHAVIPNVNVLDDLESRLVRLTDDEKRLYALICRSYLAAVMPDYEYRQTSVTMPVPMPTPGGTKPVAFRAVGRIPLKLGWKAAFGSAESDDRSGGKPEEEAEQTLPPLTDGEPATLSDPKLEAKRTQAPPRYNEGTLVDAMQNAWRFVEEPSLRDRLKEAKGIGTPATRAEVIKGLRKQNLLGADGKWLVPTPAGLHLFETLRAAAPTLVDPGTTALWEMKLDDVVTGRADFRRVIDAIATEAERLIGALVGQRGTLLDLGMPAPKARFARRGTGGRTTGAAAGAAKPVRRRTRKAEAPVEGGAAAPKPRRVRKAKAPASAPPTSAQADNGRPAAPATAPAPPNGLRRREPTERMVAFARSLAERKGIDLPDPCLRDFDQCRSFLDQHAR
(744) DNA topoisomerase 1 [Azospirillum lipoferum 4B]
1
MPGSNVVIVESPAKAKTINKYLGDDYTVIASFGHVRDLPARDGSVRPDEDFAMEWELGDRSKRHIDEIAKAVKSADRVYLATDPDREGEAIAWHLSELLREKHLTDNRDVQRITFNEITKSAVQAAIANPRDVSRELVDAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICERESEIEVFKPQEYWSIAVGFTTPAGAGFTASLTQLDGKRLDKFGLPNREAAEAAVAKILPQSFAVSSVERKQSRRNPSPPFTTSTLQQEASRKLGFGATRTMRTAQKLYEGVDIGGETVGLITYMRTDGVSLSQEAIDGARSLIGSQYGERYVPAQPRVYKTAAKNAQEAHEAIRPTDLQRRPDSVAGYLESDELRLYELIWKRTLASQMESAVLDQVAVDIANPSKDVVLRATGSIVVFDGFLKVYQEDRDDAAEDDQQERRLPAMDQGDALARGDIAQDQHFTQPPPRYSEASLVKKLEELGIGRPSTYASILQVLQDRNYVRLDKRRFIPEDRGRLVTAFLENFFHRYVEYNFTAELENQLDEISDGKIDWKTVLRDFWTAFDVAVNGTKDLTITQVLTTLDNELGAHFFPAATADGHDPRVCPVCREGRLGLKLGKMGAFIGCSRYPECRYTRPLAVANDENGEAQEGPRELGNDPETGLPVTVRRGPYGAYIQLGPAPTVAAPPEEPAVEEPAADGKKPKAKKKKKDEAPKPKRVSLPKGMAAADVDLDTALKLLALPRTIGNHPETGEEISAGIGRFGPYLKHGSVYKSLTPDDDVLTIGINRAVDLLAGAAKKASAPAKTLGDHPKTGKPITMGSGRFGPYVKHASVYASIPKGTEPDSVTLEQALELIDAKVAKDAAKKGKAPKDAEPAKAEGAEAEKPAKAKAAAKKPAAKKATKAKAAKDAPAEAAAPKKKTAKAS
(68) DNA topoisomerase 1 [Rhodospirillum rubrum F11]
1
MHVVVVESPAKAKTINKYLGKDYVVLASYGHIRDLPPKDGSVRPDEGFAMDWEIDAKSEKHVKDITQALKSADGLLLATDPDREGEAISWHVRDVLEKRKALVGKQVQRITFNAITRSAVEEALRNPRDLDTPLVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREQEVERFVSREYWTVDAILASPQGQIFRARLSQLDGQKLDKFGLPDETTALAALERIKAATLRVESVERKQARRNPAAPFTTSTIQQEASRKLYFSARQTMQVAQKLYEGVDLGGETVGLITYMRTDGVSIAPEAVFATRDLIGAEFGAAYLPEQPRVYKTKAKNAQEAHEAIRPTDVARTPQSVAPYLTAEQRKLYELVWKRTVASQMASAILDQVAVDIADPEAKVVLHATGSVIQFDGFLKVYREDFDDRPESSPDGAGEDENRLLPPLREGDGVKREDVKADQHFTQPPPRYTEASLVKRMEELGIGRPSTYASILSVLQDREYVRLDARRFIPEDRGRLVTAFLENFFSRYVQYSFTADLENQLDEISDGKLGWKTVLERFWMDFKAAIEGTATLRVSEVLDALDKELGPHLFPQAEDGHDPRVCPVCSAGRLGLRIGKFGAFVGCSNYPDCKFTRPLVTKEGEGGDGAALAEDGTKPLGKDPVSGEDVTLRKGPYGLYVQKGEAAPVEKGKKAVKPPRVSIPKDMDAATIDLDIALKLLSLPRPVGDHPETGTMISAGIGRFGPYIKHGDIYKSLPKDDDVLTIGLNRAVSLLAEAGKGGRARQPARSLGDHPADTKPVTIHDGRFGPYVQHGGVRATIPRTADPATYTLAEAVELIAAKAAKDGDGKKAPAKKAATKAPVKKAAAEKKAPAKTATKKAAPKKAADSAEDAPAKAPRKSKAKPASADPD
(1771) DNA topoisomerase 1 [Micavibrio aeruginosavorus ARL-13]
1
MSASNLVIVESPSKAKTINKYLGPDYEVLASYGHVRDLPPKDGSVDPENGFAMLWELGDRAAKPVNDIRRAVKKAKALYLATDPDREGEAISWHVQELLKDEKLLEGKQVFRVTFNEITKKAVQEAFKNARDLDAPLVEAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRLICERESEIEKFRADEYWTIEARLHNRDGAPFTARLTHLSGNKLDKLDIGSEAQATAAANRIRGKNLVVQNVEKKQVRRFPPAPFITSTLQQEASRKLGFGASQTMRLAQRLYEGTEINGDTVGLITYMRTDGTTLSEDAVTQCRDVIKSNYGPKYLPDAPRLYKSKAKNAQEAHEAIRPTDLSRTPDEVRMYVDDQMARLYELIWKRTMASQMENAVMDQVGADISDGTTDVVLRATGSTVAFDGFLTLYQEGQDDDETDEENRRLPVLDKGDATKLIDVAQDQHFTQPPPRYSEASLVKKMEELGIGRPSTYASILQVLQDRDYVRLDKKRFIPEDRGRLVTTFLSKFFTRYVDYDFTATLEEELDAIAAGQAHWKDALAQFWKDFSKAVGDTKNLTITEVIDNLDAELGPHFFPVVEHGKDPRICPACNEGRLSLKLGKFGAFIGCANYPDCRYTRPLVVPSADENAEGGEAGGESGLAAQLANAPKILGHDPVTGRAVSLRRGPYGPYVQIDPPEAPPAPAVEEKAPEVEDGTAKKGKGKAKKKKETAEKPKRQGVPKGLKLEDIDLAAALKLLELPREVGLHPETKEMIKAGIGRFGPFLVHQGSYTSIPKGDDVLTIGINRAVDLIAAKAERAANGGGRRGGWGKKKAKADGDDAAPKKTAAKKKAPDKKAAAKKPAAKKTAAKKPAAKKTATKKPAAKE
(1672) DNA topoisomerase 1 [Caulobacter sp. K31]
1
MIVVVVESPAKAKTINKYLGSGYTVLASYGHIRDLPSKDGSVEPDNDFAMHWEADAKGAKRIGDIVDAMKGADGVILATDPDREGEAISWHVLEVLQKKKAIKDKSVQRVTFNAITKTSVLEAMAHPRDIDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVCLRLIVDRELEIERFKTQEYWSVEADVTAGAEPFVARLVKHENKKLTKFDLNNESSALAAKAAVEKAVFKVAAVEKKPGKRSPAPPFTTSTLQQEASRKLGFSAQRTMQAAQKLYEGIDIGGETVGLITYMRTDGVSVEPEGIAEARSVIGSVYGETYVPETPRYYKAKAKNAQEAHEAIRPTSLKRNPGSLRLESDLGRLYELIWKRMIASQMESARIERTTVDLESADGQTGMRATGQVVLFPGYLAVYEEGRDDEGDEDSARLPMIEEGAAAKVLDARADQHFTEPPPRYSEASLVKKMEELGIGRPSTYASVLTVLRDREYVRMDKQRFIPEDKGRLVTAFLEQFFRRYVEYDFTAALEEQLDLVSDGKLDWKQFLRDFWKDFHAAVGEIAELRTTNVLDALNESLGPHIFPDKGDGSDPRLCPTCGTGQLSLKVGKFGAFIGCSNYPECRFTRQLATAEGEGEAEAADKELGINPATGRAVWLKNGRFGPYVEEPAAEGSGDKPKRSSLPKGWTPAGLDLEKALRLLALPREVGMHPDDGKKITAGLGRFGPFVLHEGTYANLENPEEVFDIGLNRAVALLADKRAGGGRPQRGQAAALADLGVHPEDGKPVKVLSGRFGPYIKHGDTNANVPKGADPAALTLAEAVVLLADRVAKGGGKKPAKKAAAKKAPAKAKAAAATDGGAPAKKAPAKKAPAKATGAKKTAAKKPAAKKAKAEA
(741) DNA topoisomerase 1 [Candidatus Pelagibacter sp. IMCC9063]
1
MNLVIVESPAKAKTINKYLGSNYIVLASFGHVRDLPSKNGSVDTENNFNMVWEIDTASKKHIKEIADAAEDCEKIILATDPDREGEAIAWHVRHILEDKNLLKGKKVERVVFNEITKKAVVYGVENPRDLNIELVNAYLARRALDYLVGFNISPILWTKLPGSKSAGRVQSVALKIIVEREYEIELFKPEEFWTLNAVFKNSQNKEINSKLNIYDSKKVEKFSFKNKKAAENAVAEINKNEFKVKSIESKPFKRNPYAPFRTSTMQQDASRKLGFGASRTMQVAQRLYQGIDIEGETVGLITYMRTDGTDISLDAVADCRTFIKNEIGEKYLPSEARNYSGKKAKNAQEAHEAIRPTDITRTPNSLKSKLDKDQMRLYELIWNRTVSSQMESAEFERTAIDFTNQSSSMIFRANGSIQKFDGFLKLYQEVKDEDDKEKEDSDEDNILPEVVKDEILKIDKVLNEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASIISVLSTRNYVEVLNKKFTPTDRGKLITSFLNQLFTRYVDYNFTAGLEESLDDITTGKADWIEVLAKFWKEFNQNVLEVKELRTRAILDMMNESLGEIIFDKDNEGKIKRSCECGGELSLKTGRFGAFIGCSKYPDCKFTRPMSRIKAAEQDYLAEPKEIGKTEDDKNIVLKKGRFGPYLQVGNDEKEMKNVSIPKGISLDDIDLDKARFLASLPKVLGQYPENSMDITLNNGRYGPYVKCDKKSATLEAPEDIFSIGLNKAITMIADAKPGRRSSNEIKLIGEHPEDKKPVKVMKGSYGPYIKYKTINATIPDDKDPESVTMEEALDLIEKRLEYDSTKKGKKIKKKTAKKRKPKKKADKNKDEEK
(892) DNA topoisomerase [Bordetella avium 197N]
5
MNKTLIIAEKPSVALDISRALGGFAREGDFFESESYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSSERLKLLVRLAKRKDVDTIINACDAGREGELIFRYIIQYAGVKKPIKRLWLQSMTQAAIREAFANLRDDVQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVAERESRIRSFVPRDYWEVHATFVAAAGLYEGRWIDPDFKKDERDPEKRESRLWSAAAAQSVVAACREQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLSLAQTLYERHKALTYPRTDSRYLPEDYVNTVRQTMRALSEGGSNAVGGLARHAGTVVSNDWVKLHRRIFDNKKVSDHFAIIPTLQIPHDLSEAEGKIYDLVLKRFLAVFFPAAEYRLTTRLTEVQGHRFKTEGKVLVAPGWLAVYGKEAQGEDANLVPVADGEKVRTEDVRAEALSTKPPARYNEATLLSAMEGAGKLVDDGELREAMSERGLGTPATRAAIIEGLLNESYLRRDGRDLVPTAKARQLMTLLAGLDVAELTSPELTGEWEHKLKQIEQGGLDREAFMREIAQMTQVIVKRAKEYERDTVPGDYATLKTPCPHCGGVVKENYRRYACTQCEFSISKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISDEYKLEFDFGQSDEEDDTPVDFSGHTPVGACPKCHSQVFEHGMSYVCEKSVGPAKSCDFRSGKVILQQEISREQMSKLLSEGRTDLLDGFVSSRTNRKFKAFLVRQPDGKIGFEFEPRGDKPARRAAAKKAPAKTATKTAAKTAVKKAASKTTTKTASKTATKTATKTAAKKAAAKKTAA
(1723) DNA topoisomerase [Pusillimonas sp. T7-7]
5
MTKTLIIAEKPSVALDISRALGGFTREGDYFESEQYVLASSVGHLLSLVAPNDPVRGKWSFTHLPVIPPQFELGPTDKRSSERLKLLVKLLKRKDVDAVINACDAGREGELIFRYIVQYSGVKKPVKRLWLRSMTQAAIREAFANLRDDDTMKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNEREERIRKFVSRDYWEVHATFVAAAGFYTGRWFDPKFVKDERDPEQRDSRLWSNTAAQTIVMACRGQSGKVTEESKPSTQMSPALFDLTSLQREANSRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYISTVQQTMEALSEGGSSAVANIRPFAETICKQKWVKPNRRIFDNKKVSDHFAIIPTLQVPRELSEAEGKIYDLITRRFLAVFFPAAEFRITTRITEVSGHHFKTEGKVLIAPGWLAIYGREAQGDDTTLIAVSEGETVKTDEVEAKGLATKPPAHFNEATLLSAMEGAGKLVDDEALREAMSERGLGTPATRAAIIEGLLNEGYLRREGRDLIPSAKARQLMTLLSGLGVNELTSPELTGEWEHRLKQIEQRELDRDAFMREIAQMTQVIVKRAKEYERDTVPGDYATLSTPCPKCGGVVKENYRRYACTNCDFSIGKHPGGRTFEIDEVEELLTKRELGPLPGFISKMGRPFAALLRITDEYKLEFDFGQKDDEDTEPVDFSGHTPVGECPKCHHKVYEHGMNYVCEKSVGPDKTCDFRTGKMILQQEISAGQVSKLLSEGKTDLLEGFVSSRTNRKFKAYLVKQPNGKIGFEFEPRPVKAGAKTAAKKAASKTASKTAAKTATKTAAKKAAAKKAATKAPAKKAAKKTAVKKAAVKKAVKAAPVTASGDDDPPF
(723) DNA topoisomerase [Achromobacter xylosoxidans A8]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESERYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPEFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIIQYAGVKKPIQRLWLQSMTQAAIREAFANLRDDSQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVAEREERIRRFVPRDYWEVRATFVAAAGLYEGRWIDPQFKKDDRDPEKRESRLWSEAAAQSVVAACREQPGNVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYIATVQETMRALAKGGSNAVGGLSRHAETVVGNQWVKPNRRIFDNKKVSDHFAIIPTLQIPHDLSEAEAKLYDLVLKRFLAVFFPAAEYRVTTRMTEVQGHRFRTDGKVLVSPGWLAVYGKEAQGEDANLVPVADGETVRTEDVEAVGLSTKPPARFNEGTLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEVYLRREGRDLVPTAKARQLMTLLSGLDVTELTSPELTGEWEHKLKQIEQGGLGREAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGAVVKENYRRFACTACDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISDEFKLEFDFGQSDEDDNEAVDFSGHTPVGSCPKCQSRVFEHGMSYVCEKSVGPEKSCDFRSGKVILQQEISREQMEKLLTNGRTDLLDGFVSSRTNRKFKAFLVRQPDGKIGFEFEPRPEKPGRAPAKTAAKTATKTAAKKAPAKKAAVKKTATKTATKTAVKKAVKKAAPKKTAA
(834) DNA topoisomerase [Achromobacter xylosoxidans A8]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDASADDAGRCLQQPIAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRTQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTVADLSCGQQKLVATGKQVVVKGWRLVLAEPEREGSADEDGDAPRSQVLPALRDGMACQVAGADIKALKTMPPKPYTQGELVKAMKGVARFVTDPRLKQKLKDTTGIGTEATRANIISGLIARGYIVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPACKGTLPVATGTSRRGASRPRRTSGGGCKGA
(172) DNA topoisomerase [Taylorella equigenitalis MCE9]
5
MSKTLVIAEKPSVATDLSKALGTFKKETGFYENDHYVISSSVGHLLTLFNPDDAVRGKWSFTNLPAIPSKKFEIQPIDKKSKERLTLLVKLIKRADIELIINACDAGREGELIFRYIMQYAKVKKPIKRLWLQSMTKQAIQEAFENLRSDESMKPLEDSARSRAEADWLIGINGTRAMTAFNSKGGGFNKTPIGRVQTPTLAIVYDRDQKIRAYEPKDYWEVVATFVASAGVYEGKWFDPEFKKNPKDPDARESRLWDANTAKTIVLACKGKEGTVTEETKENTQNSPILFDLTTLQREANSKFGYSAKTTLALAQALYEKHKLITYPRTDSRYLPEDYLNTVKENIKSMSSDSSSLHTGHKEFAQKIISNKWVKSNKRIFNNSKVSDHFAIIPTSNSTATLSEAEFKVYDLICKRFMAVFYPPAIYNVTTRITEVISYKFKTEGKILVSPGWLEIYGREEMDETLPPIKANETVLTESIESIQNKTKPPAHFNEATLLSAMEGAGKLVDSDDLREAMSERGLGTPATRASIIEGLISEQYLRREGKDLITTIKTKQLMTLLHGLSINELTSPELTGEWEYKLRQIEEGNLDRDKFMQEIAKNTQIIVKRAKEYEHDTVPGDYATLETPCPVCGGVIKENYRRYACTDCDFSITKNPGSRPFETAEVEEFLTNRSIGPLSGFISKMGRPFAAILKLTDDNKLEFDFGNDNAQEKEDIDLTALEPVGKCPKCSSNVYDTGLNYACEKQIKDKSCDFKSGKVILQQEIPLEQMQKLLSNGRTDLLEKFISNRTKRAFKAYLVLEKNGNVGFEFEKKSSTGRKSSKK
(559) DNA topoisomerase III [Comamonas testosteroni CNB-2]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFEKHDDYFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPRFDLKPVDKTKTRLNAVVKQAKRKDVTELINACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFNNLRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQAGQYLGKWFNPQWKKSDDAEAKADRLWNKADAEAIAAAVQGKPAQVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFDMLATSGMRHLAPFAQQAINDNYIRPTKRVFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAANEVEDAKEGDKGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLEVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRYACTGANGASEGCGFSFTKSPAGRTFETAEAEQLLRERRIGPLEGFRSKAGWPFVAEVAIVRDEENSNFKLEFDFGDDKDSEDTGEIVDFAHQQSLGPCPKCGSPVFEHGANYVCSKAVPTLAQTTPSCDFKSGQIILQQPIEREQMSKLLQTGKTDLLEKFVSNRTRRNFKAFLVWDGAAGKVNFEFEQREGKYPARKTAGAAAAKTTTAAAKKTGTAAKKTAAKTATKTAAVKKPRTVSATLKPSADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFELAGIVGKHVS
(313) DNA topoisomerase 1 [Rickettsia akari str. Hartford]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKASKYVDAIVKDAKKADSVYLATDPDREGESISWHVAEVIKEKNKVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDKIERFKSEEYWDISIKIQSSNNELFTAQLTHVNDQKLEKFSIINAKDAKDLTEKLKSQKFHVDKIEKKQQKRAPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDTSYGNKYLPSSPRIYKSKVKNAQEAHEAIRPTNITYTPDNLKELLEKDYYKLYELIWKRTVACQMENVIMDLVVASLASENKEYLAKATGSTITFDGFYKIYRESVDDEDEEENKMLPPLKEQESLKTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVTLEKKRFIPEELGRLVTVFLVGFFRKYVEYDFTAGLENELDEIAAGKLEWKAALNNFWSGFNNNIKSVNEQKITEIISYVQKALDYHLFGENKESKVCPSCKTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEAELSAIPNGNKILGTDKDGIEIYLKKGPYGPYIQHGEQEGKVKPKRSPIPAILNQNDITLEIALKLLSLPLKIGIHKDSGEEIMIGYGKFGPYIKYMSKFISIPKKYDFLNLSLDDAMKLIEDNNAKLETTQG
(465) DNA topoisomerase III [Polaromonas naphthalenivorans CJ2]
5
MKTLVIAEKPSVAQDIVRALTPTAGKFEKHDEYFESDDWVITSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKPMDKTKTRLNAIVKLTKRKDIGALVNACDAGREGELIFRLIQQYAKSKHPVRRLWLQSMTPAAIRDGFAALRSDAQMLPLADAARCRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRKFVSRDYWEIHALFSAEAGEYPGKWFDPKFKRAAANADNAEPDPELKADRLWTEREARAIADAVRGQTATVTEESKPTTQAPGLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYVPVVKQTFEMLATSGMNHLAPHAATALKGNYIKPTKRIFDNAKVSDHFAIIPTLQAPSGLSEAEQKLYDLVVRRFMAVFFPNAEYLVTTRISVSVGHSFKTEGKVLVKPGWLAIYGKEAAAEVPEAKEGDKGQSLVPVKPGERVGVEAADAKALKTRAPARYSEATLLGAMEGAGKTIDDDELREAMQEKGLGTPATRAATIEGLIAEKYMLREGRELIPTAKAFQLMTLLRGLDVQELSKAELTGEWEFKLAQMEHGKLSRETFMAEIAAMTKNLVAKAKGYSRDSVPGDYATLQARCPNCGGVIKENYRRYTCTGATGDGEGCGFSFGKTPAGRTFELAEVEQFLRDKKIGPLEGFRSKAGWPFTAEMVLKFDEETKNYKLEFDFGDDKNADTGEIVDFGDQESLGACPKCAANVYELGKNYVCEKSVPTLEQPTPSCDFKTGQVILQQPIEREQMSKLLATGKTDLLDKFVSMRTRRAFKAMLVWDAEAGKVNFEFAPSKFPPKPGAAPRAGAGTIKTPFGKTVAVKAAAAPAAKKAAVKKVAAKKSAAASDKPKAVRKAAAPGAGLKPSDALAAIIGSEQVARPQVIKKLWDYIKDQNLQDPANKRAINADAKLLPVFGKPQVTMFELAGIVGKHLS
(673) DNA topoisomerase III [Acidovorax sp. JS42]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFEKHEDHFENERYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKQARRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFENLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGEYLGKWFDPKWKKSDDPEARADRVWSYHQAKDIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFGMLAGSGMRHLAPFAQQALDDGYVRPSKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLDVQELCRADLTGEWEFKLAQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRYACTGANGAGEGCGFSFTKSPAGRTFETAEAEQLLRDRRIGPLEGFRSKAGWPFVAEVTIARDEEAGNYKLEFDFGDDKNAEESGEIVDFAGQESLGACPSCGAPVYEHGSNYVCSKSVPTAQQPTPSCTFKSGKVILQQPVERAQMQKLLATGKTDLLDKFVSMRTRRAFKAFLAWDKEAGKVNFEFEQRESKYPPRKTAAAKTGAASARGTGAGAVKASKPATKAAAKKAAAKTTAAKTPRKASTAAGKAPSAQLAAVIGTEPVARPEAVKKMWDYIKAHNLQDPQDKRTIVADDKLRAVFGKDRIGMFELAGILGQHLA
(53) DNA topoisomerase [Acidovorax sp. JS42]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGYRGPIARLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDASTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRAQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETIARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPDCKGTLPVETGTSKRGASRPRKSGRKGS
(574) DNA topoisomerase [Acidovorax sp. JS42]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGYRGPIARLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDASTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRAQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETTARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIVQYGSTSLSIKVPQGPACPQCGAPTRQRTGKTGPFWSCSRYPDCKGTLPVETGTSKRGASRPRKSGRKGS
(727) DNA topoisomerase [Acidovorax sp. JS42]
4
MRVFLCEKPSQGKDIARVLGAGHRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGDQYKRWAIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYHGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYMGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAVDVLLSHAGRSFTASWIPPEGSTDAAGRCLQQPVAQQAADCIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPAVLDALLATDPSLRPLIGQLDRNQRSRAWNDGKVTAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQFSCGSQSLAAVGKQIAVTGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLKALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANTINGLIGRGYLVKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMALDTFIEKQSVWVGQLVQQYRGATLSLKLPPAPACPQCGAPMQQRTGKSGAFWSCSRYPDCKGTLPIESPTGRRSAPRKRCAASKAS
(699) DNA topoisomerase 1 [Rickettsia slovaca 13-B]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKIKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPSENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(1766) DNA topoisomerase III [Acidovorax avenae subsp. avenae ATCC 19860]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKLARRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLNKPVRRLWLQSMTPQAIRDGFGNLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRQFVSRDYWEIHAGFHAEAGEYLGKWFDPQWKKVADDPEARADRVWSFERAREIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKDTFGMLATSGMRHLAPYARQALDENYVRPSKRIFDNAKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYMVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEYAEAKALKTKPPARYSEATLLGAMESAGKQVEDEELRSAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTERMVKKAKEYDRDTIPGNYATLSTPCPNCGGVVKENYRRYACTGADGRGDGCGFSFTKSPAGRTFEPAEAEALLRERRIGPLEGFRSKAGWPFTAEVTIVRDEEAGNFKLEFDFGDDRAGEASGELVEFTDEPLGPCPICGAPVHEHGSNYVCSKAVPTAAQPTPSCTFKSGKVILQQPVEREQMAKLLATGKTDLLDKFVSMRTRRNFKAFLAWDKEAGKVNFEFEPRESKFPPRKFAGKAGAAAGAAKAGTAAAAKKAAKPAAKAAAKKSSTAAKAPRKTAAGKPPSAALAAVIGPEPVGRPEAVKKMWEYIKAHNLQDPKDKRTINADAKLREVFGKESAGMFELAGILGKHLQGDSE
(83) DNA topoisomerase 1 [Rickettsia africae ESF-5]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESIDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPATMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMDQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(1643) DNA topoisomerase 1 [Rickettsia rickettsii str. 'Sheila Smith']
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDATKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTQVNDQKLEKFSIINEKNAKDLTKKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKAVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCHTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIIIGYGKFGPYIKYMGKFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(169) DNA topoisomerase III [Acidovorax ebreus TPSY]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFEKHEDHFENERYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKQAKRKDVTELVNACDAGREGELIFRLIEQYAGGAKGTLAKPVRRLWLQSMTPQAIRDGFENLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGEYLGKWFDPKWKKSDDPEARADRVWSHHQAKDIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFGMLAGSGMRHLAPFAQQALDDGYVRPSKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLIKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLDVQELCRADLTGEWEFKLAQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRYACTGANGAGEGCGFSFTKSPAGRTFETAEAEQLLRDRRIGPLEGFRSKAGWPFVAEVTIARDEEAGNYKLEFDFGDDKNAEESGEIVDFAGQESLGACPSCGAPVYEHGSNYVCSKSVPTAQQPTPSCTFKSGKVILQQPVERAQMQKLLATGKTDLLDKFVSMRTRRAFKAFLAWDKEAGKVNFEFEQRESKYPPRKTAAAKTGAASARGTGAGAVKASKPATKAAAKKAAAKTTAAKTPRKASTAAGKAPSAQLAAVIGTEPVARPEAVKKMWDYIKAHNLQDPQDKRTIVADDKLRAVFGKDRIGMFELAGILGQHLA
(1876) DNA topoisomerase 1 [Rickettsia conorii str. Malish 7]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKSHKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESMDDEAEEENKMLPPLKEQEPLKTKAVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKICPSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMIGYGKFGPYIKYMGQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
(383) DNA topoisomerase [Bordetella bronchiseptica RB50]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESDRYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIVQFAGVKKPIQRLWLQSMTQQAIRDAFANLRDDEQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNERENRIRSFVSRDYWEVHATFVAAAGLYEGRWIDPAFKKDERDPEKRESRLWSLAAAQSVVAACRAQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYINTVRQTMQVLAQGDSNAVGALSRHADTVLAQNWVKPNRRIFDNKKVSDHFAIIPTLQVPRDLSEAEGKLYDLVLKRFLAVFFPAAEYRVTTRLTEVQGHRFKTEGKVLVTPGWLAVYGKEAQGEDANLVPVADGETVRAEDVEAVGLATKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEAYLRRDGRDLVPTAKARQLMTLLSGLDVSELTSPELTGEWEHKLKQIEQGALDRAAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRFACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISGEYKLEFDFGQNDEEDNEAVDFSGHTSVGACPKCSARVFEHGMSYVCEKSVGPQKSCDFRSGKVILQQEISREQMEKLLTAGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRGDKPGRPGAAAKKAAGKTATKTAAKAPAKTAAKKAVKKAAPKKAATKTAARKAAKKSAA
(1307) DNA topoisomerase [Bordetella pertussis CS]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESDRYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIVQFAGVKKPIQRLWLQSMTQQAIRDAFANLRDDEQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNERENRIRSFVSRDYWEVHATFVAAAGLYEGRWIDPAFRKDERDPEKRESRLWSLAAAQSVVAACRAQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYINTVRQTMQVLAQGDSNAVGALSRHADTVLAQNWVKPNRRIFDNKKVSDHFAIIPTLQVPRDLSEAEGKLYDLVLKRFLAVFFPAAEYRVTTRLTEVQGHRFKTEGKVLVTPGWLAVYGKEAQGEDANLVPVADGETVRAEDVEAVGLATKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEAYLRRDGRDLVPTAKARQLMALLSGLDVSELTSPELTGEWEHKLKQIEQGALDRAAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRFACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGCISKMGRPFAAILRISGEYKLEFDFGQNDEEDNEAVDFSGHTPVGACPKCSARVFEHGMSYVCEKLVGLQKSCDFRSGKVILQQEISREQMEKLLTAGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRGDKPGRPGAAAKKAAGKTATKTAAKAPAKTAAKKAVKKAAPKKAATKTAAKKAAKKSAA
(1824) DNA topoisomerase [Nitrosomonas sp. AL212]
5
MGKSLIIAEKPSVAADIARALGSFTKNTDFFENDQYVISSAVGHLLELAIPEEYEVKRGKWSFTNLPVIPPHFDLNPIEKTSSRLKLLSKLIKRKDIDSLINACDAGREGELIFYYILRHVGTDKPVKRLWLQSMTPDAIREGFTRLMDSSEVKSLAEAAVSRSESDWLVGINGTRAMTAFNSQEGGFHKTTVGRVQTPTLAILVEREEKIKKFRPQDYWEIHATFTTSNGDYTGKWFDEKFTKDKINQESKPERLWEQTKAAIIRDKCQGKSGHVNEESKPSKEICPLLYDLTSLQRDANSRFGFSAKATLGLAQALYEKHKVLTYPRTDSRALPEDYIGTVKDTVQNLENTDYGKFCRQILASNWVVPNKRIFNNAKISDHFAIIPTSLNPTKLNEAEAKLYDLVTKRFLAIFFPAAEFLVTTRITRIENEPFKTEGKVMVNPGWQAVYGKSTKPDNAEDDNTLVAIIPGESVITEAIDIVANQTRPPARFNEATLLSAMESAGKLVEDEELRAAMSAKGLGTPATRAAIIEGLVFENYIQRVGRELHPTAKAFSLITLLRGLKIPELISPELTGNWEFQLRQIEQGNLKRTAFMEKIAEMTRHMVEQAKTHRGETIAGDFAVLKSPCPKCGGIVHETYKKFQCQKCDFALWKILAGRQFEVEEMETLITRHEVGPLQGFRSKMGQPFNAIIRLTDTLEMKFDFGNNDENQEEIDFSEQLPLGKCPKCNHAVYEHGMQYVCEKSVGAARTCDFKTGKIILARPIDRAQITKLLETGKTDLLTKFISKKGRPFSAYLVRNSDGKIGFEFEQKTAKKTTKTKSKTKQSKTRSTGNIAS
(1614) DNA topoisomerase [Verminephrobacter eiseniae EF01-2]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENERYVVTSAVGHLVEIQAPEQFEVKRGKWSFAHLPVIPPYFDLKPVDKTKGRLNAVVKQARRRDVGALINACDAGREGELIFRLIEQYAGGDKPLGKPVERLWLQSMTPQAIRDGFAALRPEQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRQFVSRDYWEVHALFGAAAGPYPGKWFNPQWKKSDDAEARAERLWSVAEAQAIAQAVRDQPASVSEESKPSTQAAPPLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFEMLAGSAMRHLAPHALTALNNGYVRMSRRIFDSSKVSDHFAIIPTLQAPGGLNDAEQRLYDLVVRRFIAVFFPNAEYTVTTRISTVSVAPNGGAAAVHRFKTEGKVLVKTGWLAVYGKEAADEVEGGKEGDKGQNLVPVQPGERVLTLQADPRGFKTKPPARYSEATLLGAMESAGKQLDDDELREAMQAKGLGTPATRAAIIEGLLTEKYMLREGREIIPTAKAFQLMLLLRGLQVEELCRADLTGEWEFKLAQMEKGQLSRAAFMADIAAMTERMVTKAREYDRDTIPGDYATLQAPCPNCAGVVKENYRRYACAGKDGASPCGFSFGKSPAGRTFETAEAETLLRERKIGPLEGFRSKAGWPFSSEIVIRYDEQTHNYKLEFDFGDDRKNAEESGALVEFKDAALGPCPLCGAGVHEHGNNYLCSKSVPTAAQPAPSCSFKSGRVILQQPVEREQMQKLLATGKTDLLDKFVSMRTRRAFKAHLVWDPAAGKVNFEFAPSKFPPRQPVAAAAKTSAHVGHAGHAGRAGSALKADRAVAAKKAPVKRVAAKVKAAAAKPPRKAA
(1287) DNA topoisomerase [Polynucleobacter necessarius subsp. asymbioticus QLW-P1DMWA-1]
5
MDNPKALIIAEKPSVANDIAKALGGFIKHEDYFESDDFVISSAVGHLLEIAAPEEYDVKRGKWSFANLPVVPPYFDLRPIAKTEARLKVLQKLIKRKDINSLINACDAGREGELIFRLIAQHAKASQSVKRLWLQSMTPAAIRDGFTHLRTDDEMQPLADAARCRSEADWLVGINGTRAMTAFNSKSGGFFLTTVGRVQTPTLSIVVEREELIRKFVSKDYWEVKAEFIASAGIYEGRWFDPKFKKDVTEPDARENRLWSEAAAQSIVAACRGKKATVTEEAKPATQLAPQLFDLTSLQREANARFGFSAKNTLGLAQALYERHKVLTYPRTDAKALPEDYLDTVKQTMENLSEHSSEYRSFAKQILQGDPKDPKTKAGYGWIKPNKRIFDNSKISDHFAIIPTLETPKTLSEPEAKLYDLVVRRFLAVFYPAAEFRVTTRITEASGHHFKTEGRVLVNPGWLTVYGRSNQADDELVPVKEGETVQTESIAAIPLKTKPPARYTEATLLSAMESAGKWVDDDEMREAMAEKGLGTPATRAAIIEGLLAEKYMVREARELIPTAKAFQLMTLLRGLDVEELTRPDLTGSWENKLSLIEQGKMKRDTFMQEIAQMTQRIVKRAKEYDSDTIPGDYATMSTPCPHCKGPVKENYRRFACEKCGFTISKTPGGRAFEYPEVEELLREKTIGPLQGFRSKMGRPFAAIIKLSEIPEDDADYPNAGFKLEFDFGNTQDDETEAIDFTGRLALGACPKCSGAVYEDGMRYVCESNTGPNKSCDFKTGKVVLQQEISQEQVQKLLKEGKTDLLTNFKSNRTGRGFKAYLALGADGKIGFEFEAKAPKAGGAAKAPAKKRAGASAATKSVAKPKRASKAKSSSSS
(661) DNA topoisomerase [Burkholderia xenovorans LB400]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEDYEVKRGKWSFANLPVIPPHFDLNPIAKSESRLKVLTKLLKRKDVDRLINACDAGREGELIFRLIAQHAKARQPVQRLWLQSMTAGAIRDGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCSAGFYEGRWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRGQIGTVTEESKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKETLGMLKESNNYLPFAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLSVFFPAAEFKVTTRITEVVGHHFKTEGKVLVEPGWLQVYGREISGEDANLVPVQKDEKVKTDRIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLIREGRDLIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACSKCEFSISKIPGGRQFEIPEVEELLQNKTIGPLSGFRSKMGRPFSAILKLSFDDEIKNYKLEFDFGQDAGGEDGEPPDFSDQQPVGACPKCKGRVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKEPSAKTVAKTAAAKAAAEAADSESEDGGAPVAVKAAPAAKKAAAKKAPATKTAAARKAPARKTAARKTGS
(1504) DNA topoisomerase [Burkholderia xenovorans LB400]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQLKRWSIEQLPIIPQNWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSASGQSFTAQWVPPDAYTDDTGRCLQQPVAQRAAQQIRGAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVSTVLDSLLRTDPSLRPIMDQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTVANLACGQQKLAATGKQVVVKGWPLVLTEPQPDEDGDAAARSQVLPALREGLACLVADVDLKALKTLPPRPYTQGELVKSMKGVAKLVTDPRLKQKFRDTVGIGTEATRANIISGLIARGYIVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYSIASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRGASRPHRSGRQGS
(1170) DNA topoisomerase [Burkholderia sp. YI23]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDDYVISSAVGHLLEIAAPEEYDVKRGKWSFTNLPVIPPHFDLNPIAKSESRLKVLTRLMKRKDIDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIREGFANLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFIAAKGIYEGRWFDPKFKRVENDPEQRDSRLWSLAAAETVVAACRGKTGTVTEESKPSTQMSPLLLDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYLSTVKDTMTMLKESNNYLPFAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLSVFFPAAEYLVTTRITEVSGHHFKTEGKVLVEPGWLQVYGREAAGEDGNLVPVQKNESVDVEKVEAHGLVTKPPARYNEASLLSAMEGAGKLVEDEELRDAMAAKGLGTPATRAAIIEGLLGEKYMVREGRELIPTAKAFQLMTLLRGLGVEELTAPELTGQWEHKLSQMERGSLHRDQFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGSQVKENYRRFACTKCEFSISKIPGGRQFEIPEVEELLREKTIGPLSGFRSKMGRPFSAILKLALDDEIKNYKLEFDFGQDSGGEDGEPPDFSEQTPVGACPKCQSRVFEHGMSYVCENSVSNPKTCDFRSGKVILQQEIAREQMQKLLGDGRTDLLTNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEAKPGAKTAAAKRGAAADAQSDSGDESGDSDVAVAAKTTRAKPAAKKAPAKKAAVKKTAARKTG
(1385) DNA topoisomerase [Burkholderia gladioli BSR3]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDDFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDIDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAKLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWYDPKFKRDEHDPEKRDSRLWALPAAETIVAACRGQIGVVSEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKQTMEMLKESNNYLPHAKQVLDKGWVKPNKRIFDNAKISDHFAIIPTLQAPKALSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDKVAAHQLVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLIREGRELIPTAKAFQLTTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDTFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIPEVEELLQKKEIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEDGEAPDFSAQEPVGACPKCGARVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLSDGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKPGAAAKKAAAKKTAAAANEDGAGSDAAEAAVPAKKMAAAKKAPAAKKTAAAKKTPARKTGS
(1840) DNA topoisomerase III [Albidiferax ferrireducens T118]
5
MCERPGAREKLDCSQMKTLIIAEKPSVAQDIVRALTPVAGKFDKHDEHFESDSYVVTSAVGHLLEIQAPEEFDVKRGKWSFAHLPVIPPHFDLKPVDKTKTRLNAVVKLAKRKDVDQLINACDAGREGELIFRLIEQYAGGAKPLGKPVRRLWLQSMTPQAIRDGFNTLRSNEQMLPLADAARCRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRAFVSRDYWEVHATFAAQAGDYPAKWFDPQWKKAAANAAAGNLEEADPELKADRLWQQREAQAIADAVRGQTASVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYLPVVKQTFEMLSKSAMRHLAPHALTALNNNYIRPSKRIFDNSKVSDHFAIIPTLQAPSGLSEAEQKIYDLVVRRFMAVFFPNAEYQITTRISVAAGHSFKTEGKVLVKPGWLAIYGKEAVDEVTDRDGAKDGDKGQRLVPVQAGERVTAQTVEARGLKTRPPARYTEATLLGAMEGAGKTIEDDELRAAMHEKGLGTPATRASIIEGLLTQKYMLREGRELIPTASAFQLMTLLRGLDVKELSKAELTGEWEHKLALMEHGQLSRAEFMAEIAAMTERMVKQAKEYDRDTVPGNYATLTAPCPNCGGIIKENYRRYTCTGKTGAEEGCGFSFGKTPAGRTFEVAEVEQFLRDKKIGPLEGFRSKAGWPFTAEMVIKFDEESKNYKLEFDFGDDKKGEESGELIDFSGQESLGACPKCGAPVFEHGKNYVCEKSVPTDAQATPSCDFKTGQIILQQPIEREQIAKLLATGKTDLLDKFVSMRTRRGFKAMLAWDAEAGKVNFEFAPSKFPPRKTAAKSAAGASVAAKTGAARAATTGAAAKKAAKKVASPKAAAKASAKTPRKAAVKKVASPAAGLQPSAALAAVIGAEPVARPQVIKKLWDYIKANNLQDAVNKRNINADAKLLAVFGKPQVTMFELAGIVGKHLA
(1785) DNA topoisomerase [Cupriavidus taiwanensis]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAKTESRLKVLNRLIKRKDVTTLINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFAALREDEDMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKNEFDPEARESRLWSEAEAKSIVAACRDKPGTVTEESRPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKQTMDMLADSSPNYLPHAKKILAQGWVRPNKKIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKVEGVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMREIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENYRRFACTACEFSISKIPGGRQFEIEEVEELLQKKEIGPLQGFRSKMGRPFAAILKLGKDDEGHYKMEFDFGQNDDDNDGEPVDFSGQQPVGTCPKCGGSVFEHGMKYVCENSTTSPKSCDFTTGKIILQQEISREQIGKLLNEGKTDLLTGFKSSRTGRNFKAFLVKQPDGKIGFEFEAREPKAGAKSAAKAPAKAASRGTAEAEAAPATKTAAKTASKTAAKTAAAKAPAKKAAAKKAPAKTAAAKKTRAAAAGE
(943) DNA topoisomerase 1 [Pseudogulbenkiania sp. NH8B]
1
MPSSLLIVESPSKAKTLKKYLGQDFEVLASYGHVRDLVPKSGAVDPDKNFAMKYQLIPRNAKHVDAITQAVAEADHIYLATDPDREGEAISWHLVQILNNKKLLKGKTAQRVVFHEITKNAVLDAIANPRDISQELVDAQQARRALDYLVGFNLSPMLWKKIRRGLSAGRVQSPALRLICERENEIRAFTEQEYWSIHLDSHKGRQKFGAKLFELGGNKLDQFDIPSEAVQADTLARLAEQPATVSNVDKKKKTRNPAAPFTTSTLQQEAVRKLGMTTDRTMRTAQQLYEGVDIGQGTVGLITYMRTDAVVLSNEALTEIRGYIESQFEPAFLPKAPVTFKNKSKNAQEAHEAIRPTSIERTPAAMKPFLTTDQFKLYEMIWKRTLACQMAPAKFDTTSVDITVGEGVFRATGQVQTFAGFLAVYEEDVDDAEDEDNAKLPALEVGDVLPVDKLYGEQHFTQPPPRFSEASLVKALEEFGIGRPSTYASIISTLKDREYVVLDKKRFLPTDTGEIVNKFLTEHFGQYVDYNFTAKLEDQLDEIANGRREWVPVMETFWKGLAKQLSEKESLSRAEVTTESLDEACPKCSKPLQIKFGKRGRFIACTGYPECDYTRDIGETAESAAAAAEEPTVIEGRTCPECGGALHIKKGRYGKFIGCANYPKCKHIEPLEKPRDTGVTCPECKTGSLIERKSRYGKLFYSCNTYPKCKYATWNPPVAEPCPKCHWPILTIKTTKRRGTEKVCPQKECGYSEVIAPPEAKEA
(1784) DNA topoisomerase 1 [Laribacter hongkongensis HLHK9]
1
MPANLLIVESPSKAKPLKKYLGADFEVLASYGHVRDLVPKNGAVDPEHDFAMKYQIIAKNAKHVDAIASAVREADNIYLATDPDREGEAISWHLLQILQSKKLLKDKNVQRVVFHEITQNAVLDAVAHPRNILQELVDAQQARRALDYLVGFKLSPLLWKKIRRGLSAGRVQSPALRLICEREAEIRAFETREYWSVHLDSHKGRQKFSARLTDWLGRKLDQFDIPDETSQAGILAALAGKPASVTAVEKKKKSRSPAAPFTTSTLQQEAVRKLGMTTDRTMRTAQQLYEGVDVGQGQVGLITYMRTDAVVLSNDALTEIRYYIGEHFDADYLPKSPVSYKNKSKNAQEAHEAIRPTSIFRTPESVKPFLTPEQFKLYTMIWKRTLACQMAPAKFDTTAVDITVGDGVFRASGQVLTFPGFIAVYQEDKDSDDAAAGDDDEARLPVLEVGDELPVDKLYGEQHFTQPPPRYSEASLVKALEEYGIGRPSTYASIIKTLKDREYVTLEKKRFEPTDTGDIVNKFLTEHFEQYVDYNFTARLEDQLDDISNGKRQWVPVLDSFWQGFKKQLEEKEGISRAEVTTQQLDEACPKCGKPLNIRFGKRGRFIGCTGYPECDYTRNLNETAEEAAAAAAAEQEELVVIEDRVCPEDGGQLVIKKGRFGKFIGCANYPKCKHIEPLEKPRDTGVTCPVCKTGHLVEKKSRYGKLFYSCNTYPKCTYAVWNPPVAENCPQCGWPVLTIKTTKRRGTEKVCPQKECGWSEVIAPPAGKDEAPAD
(1018) DNA topoisomerase [Burkholderia thailandensis E264]
5
MCYKAVVKGPASGSPGPSIHTVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDVDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDQLGTVTEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDETKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQADGKIGFEFEKKEPKPAAAKKTASKSTAAAADAAADSDDKAEKKTAPARKTAARKTPARKTGS
(1112) DNA topoisomerase [Burkholderia rhizoxinica HKI 454]
5
MRLRPICYKAFDSAHPYFPIVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDDYVLSSAVGHLVEIAAPQEYEVKRGKWSFAHLPVIPPHFDLQPIAKSESRLKLLTRLIKRKDVDRLVNACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPAAIRDGFAQLRSDQEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCATGSYEGRWFDPKFKKNEFDPEQRDSRLWSAAAAETIVAACRGQIGTVSEESKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLALAQALYERHKVLTYPRTDARALPEDYMAAVRDTLEVLKESNNYLPFAKQVLDKGWVRPNKRIFDNTKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVVGHHFKTEGKVLVAPGWLQVYGRETSGEDANLAPVAKDEKVQTDKIAAQQLTTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVEELTAPELTGEWEHKLSQMERGRLEREAFMREIARMTQTIVKRAKEYDSDTIPGDYATLKTTCPNCNGEVKENYRRFACTKCDFSISKIPGGRQFEIDEVEQLLSEKSIGPLSGFRSKMGRPFSAILKLARDEEANNYKLEFDFGQDTMGEEGEAPDFSSQEPVGQCPKCHARVFEHGMSYVCENQAAHPKTCDFRSGKVILQQEITREQMAKLLDQGRTDLLTNFKSSRTGRNFKAFLVKQKDGSIGFEFEKKEPAAKTAAKSSTRGAKANSGAGDAGPDTTQRGDSHRATSLKPAAKRATRTATATAGPAAKTTARKTPARKRAAG
(1292) DNA topoisomerase [Burkholderia multivorans ATCC 17616]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFACAAGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYIGTVKSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEYRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVQVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDEIKNYKLEFDFGQDQGGDEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMAKLLADGRTDLLPNFKSSRTGRNFKAYLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDTETVTEGADEKPAPARKTAARKTTTRKTGS
(1291) DNA topoisomerase [Burkholderia multivorans ATCC 17616]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFACAAGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYIGTVKSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEYRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVQVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDEIKNYKLEFDFGQDQGGDEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMAKLLADGRTDLLPNFKSSRTGRNFKAYLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDTETVTEGADEKPAPARKTAARKTTTRKTGS
(1646) DNA topoisomerase [Ralstonia pickettii 12J]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDEYVLSSAVGHLVEIAAPDEYEVKRGKWSFAHLPVIPPHFDLRPIAKSESRLKVLTRLIKRKDVTGLINACDAGREGELIFRLIAQHANTKLPVKRLWLQSMTPQSIRDGFGKLRSNEDMMPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKRFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKDEFDPERRDSRLWSEAEAKSIVAACRDKPGSVTEESKPSTQMSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYMGTVKQTLDMLGESSPNYLTHAKKILANQWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEYQVTTRVTEVAGHHFKTEGKVLVNPGWLVVYGREAQGEDANLVPVAKDEKVKTDKVEPVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVEELTQAELTGGWEHKLSLIERGQLERDEFMREIAQMTQQIVKRAKEYDSDTIPGDYATLSTPCPQCGHVVKENYRRFACSHCDFSISKIPGGRQFELDEVEELLTNKTIGPLQGFRSKMGRPFAAILKLAQEDGHWKMEFDFGQNDEDDGEPVDFSGQESVGHCPKCNGNVYEHGLKYVCENAVAQPKTCDFTTGKIILQQEISREQLAKLLTEGKTDLLTGFKSARTGRNFKAFLVKQPDGKIGFEFEPRGEGKGKPGAKTAAKKTTAAAKTPAAKKAPAKTAGKTAAKKAPARKKATEAETDEESTSET
(1730) DNA topoisomerase [Janthinobacterium sp. Marseille]
5
MTKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDEYVLSSAVGHLVEITVPEEYDVKRGKWTFTHLPMIPPHFALNPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQYTKAKQPIKRLWLQSMTPGAIREAFKNLRSDDEMLPLADAARCRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVRAEFICAAGIYQGRWLDTAFKKDETDPERRAERLWSKAAAESIVAACRGKQGNVTEESKPTTSMAPALFDLTSLQREANARFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYLPTVLQTLDVIAENNNYHQFAKQITDNKWVKPNKRIFDNTKISDHFAIIPTTQAPKNLSEPEQKLYDLVTRRFMAIFFPAAEFQVTTRFTEVSGHQFKTEGKVMTNPGWLAVYGKEVIDEKDPENSGTLVPVAKGEKVKTESVVANGLVTKPPARYSEATLLSAMEGAGKLIDNDGLRDAMAGKGLGTPATRAAIIEGLLNEKYLLREGREMIPTAKAFQLMTLLRGLGVNELTAPELTGEWEYKLSEMERGKISREEFMREIAQMTQVIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKTPGSRQFEIAEVEELLTNKTIGPLQGFRSKMGRPFAAVLKISRDEEIKNYKLEFDFGQNDDDENAEAVDFSGQTSLGPCPKCAGGVYELPLSYVCENSVAKPKTCDFRSGRIILQQEILPEQMSKLLNEGKTDLLPGFVSQRTRRAFKAYLVRGKDGKTSFEFEPRKEKAPAKGKAAAVADDAAEAGDDTAVAAKPAKKAAAKPAAKKAVAKKKAPAKKAAAKA
(401) DNA topoisomerase III [Polaromonas sp. JS666]
5
MKTLVIAEKPSVAQDIVRAITPTAGKFEKHDEYFESDEWLVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFEVKPIDKTRTRLNAIVKLAKRKDVGAIVNACDAGREGELIFRLIQQYANSKHPVKRLWLQSMTPAAIREGFDSLRSEKQMQGLADAARSRSEADWMVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRKFVSRDYWEIHASFLAEAGEYPAKWFDPKWKKAAANADNAEPDAELRADRVWSEREALAIAEAVRGKAATVTEESKPTTQAAGLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYLPVVKQTFEMLADSGMRHLAPHAATAIKGNYIKPSKRIFDNAKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFYPSAEYLVTTRISQAVGYSFKTEGKVLVKPGWLAIYGKEAADEVADAKDGDKGQSLVPVKPGEMVRAEVVEAKGLKTRPPARYSEATLLGAMEGAGKTIDDDELREAMQEKGLGTPATRAATIEGLIAEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSKAELTGEWEYKLAQMEHGKLSRETFMAEIAAMTENLVNKAKGYDKDTIPGDYTTLQTPCPNCGGVVKENYRRYTCTGKNGGDGCGFSFGKTPAGRTFETAEVEQFLRDRKIGPLEGFRSKAGWPFTAEMVIKFDEETKNYKLEFDFGDDKNGETGEIVDFGDQQSLGPCPRCAARVFELGKNYVCEKSVPTLEQPTPSCTFKTGQVILQQPIEREQMHKLLETGKTDLLDKFVSMRTRRPFKAMLAWDKEADKVNFEFAPSKFPPRKPAAAKTGVVKTPFGKTVAAKGAAGDAAPAAKKAAAKKVAAKKAPAKTAAPKVARKAATPKPGAGLKPSDSLAAVIGAEPVARTQVIKKLWDYIKAEGLQDAANKRAINADAKLLPVFGKPQVTMFELAGIVGKHLS
(1783) DNA topoisomerase [Herbaspirillum seropedicae SmR1]
5
MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGKWSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQYTKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDKGHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFSKQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPAEFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKTDKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLLNEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFMREIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVPGGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAEGEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPEQMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAKAPAKGKAAAADADDGADEAVAKPAAKKTATKTAAKTTATKAKAAAAKKPALRKATPKKAAAPDA
(76) DNA topoisomerase [Alicycliphilus denitrificans BC]
4
MRVFLCEKPSQGKDIARVLGAGQRSNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQYKRWAIEQLPIVPERWRVEPKVATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAADVLLSHAGQSFTASWIPPEGSTDAAGRCLQQPVAQQAVDRIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSRQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPAVLDALLATEPSLRPLLGQLDRNQRSRAWNDGKVTAHHGIIPTLEPAKLLAMSEKELAVYQLIRGRYLAQFLPHHEFDRTVTQLACGGQSLVAVGKQIAVIGWRQVLATPEPDAADGEEAQRSQVLPPLASGSRCGVEQVELKALRTLPPKPYTQGELVKVMKGVAKLVDDPRLKQKLKETTGIGTEATRASTIKGLLDRGYLLKKGRAIRASDAAFTLIDAVPAAIADPGMTAIWEQALDMIEAGQMTLDTFIAKQSTWVAQLVQQHRGATLSIALPPSPPCPQCGAPMRQRTGKSGAFWSCSRYPDCKGTLPVESSASKRGAPRKRRTVPKAS
(859) DNA topoisomerase III [Alicycliphilus denitrificans BC]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLAAVVRQAKRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFEHLRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFQAEAGQYLGKWFDPKWKKSEDPEARADRVWSLKEAEAIAHAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKNTFAMLAGSGMRHLAPYAQQALDDGYVRPSRRIFDNAKVSDHFAIIPTTQAPHGLSEAEQKLYDLVVRRFMAVFFPSAEYLVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAASEVEGGKEGDKGQPLVPVKPGEMTHTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDEELRSAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLQVEELCRAELTGEWEYKLAQMEKGQLSREAFMQQIQAMTEKLVRKAKEYDRDTIPGDYATLATPCPNCGGVVKENYRRYACTGAGGSGEGCGFSFGKSPAGRTFETAEAEQLLRERRIGPLEGFRSKAGWPFTAEVTIARDEEAGNYKLEFDFGDDKNAEESGEIVDFAGQESLGRCPVCGAPVYEHGGNYVCAKAVPTAQQPVPSCSFKSGKVILQQPVERAQMHKLLATGKTDLLDKFVSMRTRRPFKAFLAWDAAAGKVNFEFEQRESKYPPRKTAAAAKTGAASARGTGAAGPKTSKPAAKKTAAAKTPRKTGAAGKTPSAQLAAVIGAEPVARPEAVKKMWDYIKAHNLQDPKDKRTIVADDKLRAVFGKDSIGMFELAGVLGRHLA
(1209) DNA topoisomerase [Sorangium cellulosum So ce56]
7
MIAVVAEKPAVARDIAAVLGASKRAEGFLEGGGYVVTWAIGHLVAIAEPHQIDPAWKRWRLDLLPMLPGQFPLVVLPGTRAQFEIVRKVLGRRDVERVVCATDAGREGELIFRYIYEAAGCKKPVERLWISSLTPDAIRDGLRRLRDARGYDGLADAARGRSRADWLVGMNLSRAYSLVFDQDLSVGRVQTPTLSMVVERELAIRRFVPEPYLEVVATFCPLREDASGAADESYKGTYFNDKPVPGEPPGAGERPNAGERPNAGERPNAGERPNAGERPNAGERPETAPSRRRLPPDGEEARRIIERARRGEARIEAVRSESRRLPPPLLYDLTELQRHANRLYGFSAQKTLEVAQALYERRKLISYPRTDSRHLSTEVAATLGAAVQAIEGSYRGMLAPGTGARPLGKRFVDDGKVGDHHAIIPTGARSSRAELSTDEQKIFDLICRRLLSAWHEDHVTSITTVITAITTRGGAGARGGEPIVDRYHSAGSVVEKVGWKVLDIGFGKPPARPRRKGESDGDGPDAPDARDGEGGEGERETADQRLPPGLARGQVQLVLDAEAQAKKTRPPPRFTEATLLTAMETAGSSLEEKELSAAMKDSGLGTPATRAAIIETLLRREYIVRKGKLLHATDKGVGLIEVVHADVKSPAMTGAWEAKLARMARGGGDLPSFMAGIESYVRQVVAEVSAGRRAAGGGALSPEAGASPFQERGEARSRAKGDRAAAAAPGTGRGREATPRRAPGSSAGAVPGDASAGTLQAVAAAAAASPPARAQARSRAAAPSPARPAAATARRVAVAPSTARPVAATSPPARSAAIAPSLARPAAATSPPARPAAVAPPPARAAAIGSFPARGAGTASSPAVASSPARRPEDLVELLHQCFGFSAFRPYQEAVCRTAAAGSDVLLVMPTGAGKSLCYQLPGIARGGTTLVVSPLIALMEDQASKLRACGFAAERIHSGRSRAESRKACIDYLEGALDFLFIAPERLRVPGFPELLARRKPVLVAVDEAHCISKWGHDFRPDYRMLGQRLPALRPAPVIALTATATPVVQDDIVEQLGLASAARFIHGFRRSNLGIEILEVSPGERLARVRALLGQEGRTPAIVYAGTRKDAEALAAGLSEDLPAEAYHAGLAAPVRDRIQAAFLDGSTEIIVATIAFGMGIDKPDVRTVVHAGLPGSVEGYYQEIGRAGRDGLPSRAVLMHSYVDRRMHEFFHERDYPDPAMLQRIEEVLSEEPRPKEAILGDLGIDPEVADKALEKLWIHGGARVDPDGGIALGEPGWRGPYEAQRRHKLAELVQMARFTEGHGCRMLHLVRHFGDQEDTGEPCGLCDVCAPAACAAREFRAPSRDEAQAIAKILAALRESEQPTGRLYREAFADGSLERRDFEHLLGGLVRAGLVCVREDSFEKAGELITYQRASLTSRGLLGGPRGASDVVGDVPLAKLPPKVKKRQSATSSDARRAFFARKAQRKKGRSR
(742) DNA topoisomerase 1 [Sorangium cellulosum So ce56]
1
MAKTLVIVESPAKAKTIKKYLGNGYEVFASKGHVKDLPKKQNAVDVQNDFAETYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIAFHISEEIKNPKLKVARVEFHEITKKGVDHGVHNPRKLDENLYDAQRARRVLDRIVGYDVSALVWSKLAFGLSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAKLASADGKKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQDATNYLHFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVVAKRYGKEFVPERPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLYKLIWNRFVASQMTPAVYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQEFAGEEESAGAAADGGAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPPGVITDQKFTQPPPRYNEGSLVRELEKRGIGRPSTYAEIISKVQQRAYVEKRDGGAFQPTLLGKFVVDGLVRSNLDIMDPNFTAQMEEELDAVGAGSLKREQLLKSFYKKFREQLDKSKKLAPWKPEAEKTDIVCDECGSMMLKKWGKNGWFLSCERYPKCKATRDLSDARGTAAVRETDISCDKCGKPMIIKTGRFGDFLSCTGYPACKNTRPVPLGVACPSCGGDLIEIRPRKKGGRTFYGCSNWNAEQKCEFKLWQKPVPVPCPQCGAKFVTRTAGKKAMLVCATKDCGFKQEIVEGEGEDGAADGAATPDAAAVVASAAPAPAARPAPAEPTPAGRPEAAPEGAGAAQGAAEKPARAVRARRTAS
(1758) DNA topoisomerase 1 [Haliangium ochraceum DSM 14365]
1
MADQQAISKKRANDPANQADAADDNTSAKGATSEKSASKKAASPSKKTSTKKASTKKTAKKASTKKASTKKTTKKASAKKASAKKTAKKASAKKTTKKASAKKASAKKSASQEAAEDEGESAPKRTKSRSKATKQGKALVVVESPAKARTIGKYLGPDYTVKASVGHIKDLPKNKIGVDVDQAFEPEYVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAWHIAEEIKPINDNIKRILINEITKKGVNHAIANPTVLDTNKTDAQQARRILDRLVGYEISPILWKKVRRGLSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHRWDGAKAEPKTEAQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEASRKLRFSAKRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQGTYGPEFLPAKPHTYKSPKRAQDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYTLIWQRFVASQMAPAVYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAADQDKLLPHLEEGMAIHFDAIRPEQHFTQPPPRFTEASLVKELEERGIGRPSTYASIISTITDRGYVERREARFFPTELGAIVNDLLVESFPKIMDVDFTAAMEADLDKVEEGERDWRELLGGFYEPFRGNIEHAKENMRDVKREEIPTDHVCEKCGAPMVIKWGRNGSFLACQAYPDCRNTKEINRNPDGSFEIVPEQTTDETCSECGAPMVVKRGRFGAFLACSTYPECKNTQPISLGVDCPKDGCGGFLTEKRSRRGKPFYGCSNYSKTGCDFVTWDRPIAEACPVCEASFLVKKETRRGTTVRCLSCDYKTEQAGESAA
(993) DNA topoisomerase [Haliangium ochraceum DSM 14365]
7
MTATTLIIAEKPSMARDIARVVGARSKREGYLEGGGYWVSWCIGHLAELCEPHEYDAKWKSWSPSLLPILPDELRVRPSRSGAAHLRVLHRLMRAREVGTIVNACDAGREGELIFRHVHALSNTRKPVRRLWISSLTGEAIRRGMSALRPGAEFDDLADAARARADADWLVGMNATRALTGLVRSGGTRGLLMSVGRVQTPTLALIVRREREIESFESKPFWQVLATFAVPGEAGASYEGIWQRPREAGDDAGDAQRDNKGDAQRDNKGDGDTNTARDRSRVPTRQQADAIADAVRGRAGTITQLTRKSTRERPPLLFDLTNLQKLANRRFRMSAKRTLELAQALYETHKLITYPRTDARYLTDDLAPTLPELVRALAGEYPGLRDTALAGAAHAAGNRRIFDNAQVGDHHAIIPTAKAPSPGRLSADERRLYDLIARRFLASLFPDAVYDQTKIVTTVAGHCFATERRVCAEPGWQQAEPPPPAKRNEPPLPRLRQDMEVDTAAIEVREGKTQPPKRYSEASLLGAMEHAGRSLDDPGLRRVMRDAGLGTPATRAAIIETLLKRSYIERQGRELVPTEQGRALIASVPIEDLLSAELTADWEQKLDAIARGRASKARFMDEIHGYVRRIVDALAQATPPSLPSPTDEVLGLCPVCNGVVTEGFKTFQCASGKSCSFVIFKRIAGRKTSAALVRVLLARGRTQTLKGFRSKRGKRFSAVLTLDAEGKVQFAFDNPRGGATKSAGSAKGAKKSASSASGAKKSAASASGAKSAAAGGSGPRCPACRQGRIITGRRAWGCSRWREGCGFTVGFQQGEVRVSEEQAERLFRRGQTVLLDGLMPERRARLVLDLEAEGNVRVEPGKRARRT
(1781) DNA topoisomerase [Thauera sp. MZ1T]
4
MRVFLCEKPSQGKDIARVLGAVQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQYKRWAIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSMPYWAVDVLLSHAGQSFTASWIPPEGSTDAAGRCLQQPVAQQAADRIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLDSLVKTDPSLRPLIERLDRQQRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLICAHYLAQFLPHHEFDRTVAQFSCGSQSLAAVGKQIAVTGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLKALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYLVKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMALDTFIEKQSVWVGQLVQQYRGATLSLKLPPAPACPQCGAPMQQRTGKSGAFWSCSRYPDCKGTLPLESPTGRRSAPRKRRAASKAS
(1392) DNA topoisomerase [Thauera sp. MZ1T]
5
MSKQLIIAEKPSVAQDIARALGGFTKEKDYFESDEYVLSSAVGHLLELTLPEEFEVKRGKWTFAHLPVIPPHFAVKPIEKTEDRLKLLTRLIKRKDVTGLINACDAGREGELIFNFIAQHAGTKKPMQRLWLQSMTAQAIRDGFAHLRAAQDVEGLRNAAICRAESDWLIGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLAMVVEREDRIRKFKSRDYWELEARFGCAAGEYPGRWFDEKFKRPEGDEHATAFRLWDKAQAEAIRAKCAGKPGVVSEEAKPSTQLSPLLFDLTSLQREANGRFGFSARVTLQLAQALYEKHKVLTYPRTDARALPEDYLATVGEVMRTLPDQYAPFANEITRQGWVRPNKRIFNNAKISDHFAIIPTGALPKSLSDAEHKIYDLVTKRFLAVFYPAAEYQITTRITRVEGEAFKTEGKVLVNPGWLTVYGKEAANDEKDAKDGGAPQLVAVKQGETVSTEDIVVKSLQTKPPARFNEATLLSAMEGAGKMVDDEELRAAMAERGLGTPATRAQIIEGLISEQYIHRDGRELIPSAKAFSLITLLKGLGVTALTSPELTGGWEYKLAQMEHGKLSREAFMNEIAEMTREVVERAKRYESDTVPGEFVTLQTPCPKCGGVVKENYKKFACQACDWSTWKIVAGRQFEYDEIETLLRAGKVGPLLGFRNKMGRLFNADIVLNEDKQPTFDFGQPKEGEEAEEVDFSDQQPVGACPKCASRVFEHGMAYVCEKSVGPGKSCDFRSGKVILQQPIEREQMARLLTEGKTELLKGFVSARTRRKFSAFLVRGKDGKVGFEFEAKAPKAGAKPAAGKGDEAAGEDAEPAAPRKRAARKAS
(1680) DNA topoisomerase [Dechloromonas aromatica RCB]
5
MPRHPTGQTMSKKLIIAEKPSVAADIARALGGFTKHDDYFESEELVLSSAVGHLLELACPEEFEVKRGKWSFAHLPVIPPHFALKPIEKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFNYIAQNAKSGKPVQRLWLQSMTQGAIRDGFSRLRPGQEMEGLGDAAVCRSESDWLVGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLAIVVERERKIRDFKSRDYWEVEADFTAKAGSYKGKWFDEAFKGKNDDEHARADRLWEVARAEAIRAATEGKPGEVTEEAKPETRLSPALFDLTTLQREANARFGFSAKTTLSLAQALYEKHKVLTYPRTDSRCLPEDYLPTVKETLTILTGEGAGKGHDEVLLARYSPFAHQILARNWVLPNKRIFNNAKISDHFAIIPTPQAPKSLNEMEQKLYDFVVRRFLSVFFPAAEYMVTTRITRVEGHPFKTEGKVLVNPGWLAVYGKEGQDGDEGNLVAVDAKEKVKTDEVTVKANATKPPPRYSEATLLSAMEGAGKMVDDEELKAAMAGRGLGTPATRAQIIENLIGEQYMHREGRELIPTAKAFTLMTLLNGLGIKELTQPELTGDWEWKLGRIEKGEFTRDEFMREIAEMTRHMVERAKQYEADTIPGDFGVLTAPCPKCGGQIRETYKKFQCGSCDYALWKIVAGRQYEPAEIEQLLTEKQVGPLTGFRNKMGRSFSAAIKLNDELQPEFDFGQDKADAADAEPVDFSAQESLGKCPKCAANVFEHGTSYVCEKSVGPAKTCDFRSGKIILQQPIDAAQMKKLLADGKTDLLKEFVSNRTRRKFSAYLVNQGGKVGFEFEKKVAKPKAPAKKKTEA
(1099) DNA topoisomerase 1 [Methylobacillus flagellatus KT]
1
MSKLLIVESPSKAKTLKKYLGKDFEVLASYGHVRDLVPKTGAVDPDHDFAMKYEVIDRNARHVDAIAKAVKTADAIYLATDPDREGEAISWHIAEILKSKKLLKDKLIKRVVFHEITKNAVQNAIEEPRDISMPLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWTIHLESAKHQHVFDAKLVQLEGKKVEQFTITNQAQQQEVVGKLLAVSAGKTTVSRVEKKQRSRSPAAPFTTSTLQQEAVRKLGFTTSRTMRVAQQLYEGIDIGSGTMGLITYMRTDSFSLATEAVMQIRDYIKQNFAAEYLPKSPIMYKTKAKNAQEAHEAIRPTDISRTPASMRAFLTDEQFRLYEMIWKRALACQMTQAKFDAVSIDLAVGSDANLFRATGQTLIFPGFIAVYMEGVDDEEEEGESKLPHLETGEVLAVQKIYGDQHFTEPPPRYSEASLVKALEEYGIGRPSTYASIISTLQDREYVVLDKKRFIPTDVGRVVNKFLTEHFTRYVDYGFTANLENELDDIAEGEREWIPVLNEFWQGFNNQIHEKSNVERPGVEMLDEACPKCGKPLQSRLGRFGKFIGCSGYPECDYIRNPNANANNNEPTVIGQEPESGKDILLLNGPYGPYLQIGLPEADSKKKPKRVSIPKEIPVSSLDMETALKLIALPRDLGQHPETGKKVVANIGRFGPYVNHDGKFKSIPKSESVFDIDLARAIELLAQANAGAAPIKELGNHPDGTGNIAIYAGRFGPYVQHGKLRATLPKGQEPETLTMEQALELLSAKAAKDAPAKKAKTTTAKKTSSTKKAATTTRRKKASAGESE
(100) DNA topoisomerase [Azoarcus sp. BH72]
5
MSKQLIIAEKPSVAQDIARALGGFTKEKDYFESDDYVLSSAVGHLLELAVPEEFEVKRGKWTFAHLPVIPPHFALKPIEKTDDRLKLLTRLIKRKDVTGLINACDAGREGELIFNFIAQHAGTNKPMQRLWLQSMTPAAIRDGFAHLRAARDVEGLRNAAICRAESDWLIGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLAIVVEREDKIRKFKPRDYWELEATFGCAAGEYTGRWLDENFRKPEGDEHANAHRLWDKARAEAIRAKCEGKPGVVTEEAKPSTQLSPLLFDLTSLQREANGRFGFSARVTLQLAQALYEKHKVLTYPRTDARALPEDYLGTVKDVMAGLPDTYAPFANEIAKQGWVRPNKRIFNNAKISDHFAIIPTGTLPKSLSEAEHKIYDLVTRRFLSVFYPAAEYQITTRITRVEGEAFKTEGKVLVNAGWLAVYGKEAANEDGEGKDAGKDSGRQLVAVKPGETVSTDDILVKALQTKPPARFNEATLLSAMEGAGKMVDDEELRAAMAERGLGTPATRAQIIEGLIAEQYIHREGRELIPSAKAFSLITLLTGLGVNALTSPELTGGWEYKLSRMERGELSREAFMHEIAEMAREVVERAKRYESDTVPGDFVTLKTPCPKCGGTVKENYKKFACQACDWSTWKIVAGRQFEIDEIETLLRDGKVGPLLGFRNKMGRLFNAEIKLNDDKQPEFDFGQPKEGEEGGEAVDFSGQQSIGACPKCGANVFEHGLAYVCEKSVGPGKNCDFRSGKIILQQPIEREQMAKLLTDGKTDLLKGFVSARTRRKFSAFLVRGKDGKVGFEFEAKTPKAGAKSTPAKAAANEETGKPAPRKRAGGKTAG
(792) DNA topoisomerase [Aromatoleum aromaticum EbN1]
5
MSKQLIIAEKPSVAQDIARALGGFTKEKDYFESDEYVLSSAVGHLLELAVPEEYEVKRGKWTFAHLPVIPPRFALKPIEKTDDRLKLLTRLIKRKDVTGLINACDAGREGELIFSFIVQHAKTDKPISRLWLQSMTAGAIRDGFAQLRSAQEVEGLRSAAVCRAESDWLIGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLAIVVEREEKIRRFKPRDYWELEATFGCKAGRYVGRWFDESFRKPEGDEHATAFRLWDRARADAIKAKCDGKPGIASEESKPSTQLSPLLFDLTSLQRDANGRFGFSARVTLQIAQALYEKHKALTYPRTDARALPEDYVGTVKDVLHALPDDYAPFAGEIMKQGWVRPNKRIFNNAKISDHFAIIPTGTVPKSLSEAEQKIYDLVTRRFLAVFYPAAEYRITTRITRVENEAFKTEGKVLVNPGWLAVYGKEAAKADDEGGAQLVAVEQNERVATEDILVKALVTKPPARYNEATLLSAMEGAGKMVDDEELRAAMGERGLGTPATRAQIIEGLIAEQYLHREGRELIPSAKAFSLITLLKGLDVSSLTSPELTGEWEHKLAQMERGQLSRPEFMREIAEMAREMVERAKRYESDTVPGDFATLSAPCPKCGGVVRENYKKFACQACDWSAWKIVAGRQFEIHEIETLLRERRVGPLTGFRSKMGRLFNAEIRLNDEQQPEFDFGQPKDDGEGAEPVDFSAQEPLGPCPKCGARVFEHGMAYVCEKSVGPEKSCDFRSGKVILQQPVEREQMVKLLADGRTDLLKGFVSTRTRRKFSAFLVRGGDGKVGFEFEAKTPKAGAKGKTAAAADDEKPPVAATATAKPARAPARKRSSAA
(1420) DNA topoisomerase [Aromatoleum aromaticum EbN1]
4
MRVFLCEKPSQGKDIARVLGAGQRRNGCYSGAGIVVTWCIGHLVEAVPPEGYDERDKRWVIEQLPIIPERWRVEPKAATAAQFKIVKQLVGQATELVIATDADREGEMIAREIIELCGYRGAIQRLWLSALNDASIRKALGALKSSAETLPLYYSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSAPFWAVEVALSHAGQPFTASWTPPEGCTDEAGRCLQQPVAQQAAERMRATGSAQVASVETERVREGPPLPFDLGTLQELCSQQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLDSLVKTDPSLRPLIDRLDRNQRSRAWSDAKVTAHHGIIPTLEPANLSAMNDKELAVYKLIRAHYLAQFLPHHEFDRTVAELACGGQSLLAVGKQIAVAGWRQVLASSEEGGADSDDAQRSQVLPALRAGLSCQVGHVDLKALKTLPPKPYTQGELVKAMKGVARLVTDPRLKQKLKDTTGIGTEATRANIISGLLGRGYLLTKGRAVRASDAAFTLIDTVPAAIADPGTTAVWEQALDMIEAGQMTLDAFIAKQSAWVTQLVQQYRGTTLAIKLPPSPSPSCPQCGAPMRQRTGKSGAFWSCSRYPDCKGTLPVDTSTGKRSASRKQRASPKAS
(670) DNA topoisomerase III [Stigmatella aurantiaca DW4/3-1]
7
MGTAPEQEKTRQAGGGVAPRGPSSVLAVVAEKPAVARDIARALGATQRGEGWFRGNGYVVTWAIGHLVGLAQPHEMHPAWKRWHREQLPMLPSTWPLVVSENTRTQFEVVRAVVNAPEVSGVVCATDAGREGELIFRYIYEAAGCRKPVKRLWVSSLTEGAIREGFRTLKDGRAYDALADAAKGRSRADWLVGMNLSRLYTLACGETLSVGRVQTPTLAMLVERELAIRDFVPEDYLEVVATFAPQAAGVPAGTQYRGTWFREAEPKGGPRTAETAREARRLPADGVEAGEVMARVRSGAAVIESLTSETKRMAPPLLYDLTELQRHANRLYGFSAQRTLELAQNLYEKHKLLSYPRTASRHLSSAVAETLPEVVRAIRAPYEPLLAPGTGEKPLGRRFVDDAKVTDHHAIIPTATSPEGERLPPDEKRLYELVCRRLLAAWHDEHVWAVTTVVTAVSSVGPAPGSPRVDRFHSSGTQVVRVGWKVLDIGGGQRPPKGREGKGPKEEGEGKEPEDEPQDLPAVLARGQKQRVEDVEAVKKRTRPPPRLTDASLLTAMETAGRTLDEKELADAMKETGLGTPATRAAIIEVLLEREYLQRRGKSLEVTEKGIRLIQVVHPDVKTPAMTGQWEAWLQRIERGQGDLQAFLRGIEAYVIEVVGKMPAQPMPPRAEGPRPPPPSGAPASGAPPASVPAVSVAARAPLSAPRPASPSPSSPAAMRVRVEAPQGASKRSVERTPRAPTPPGELRKLLKEAFGFEDFRPYQEEVCKAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQVTRLQSLGFAAERIHSGRDRAASRQVCTDYLEGRLDFLFIAPERLGVPGFVELLARRPPALIAIDEAHCISQWGHDFRPDYRLLGARLPLLRPSPVVALTATATPDVQRDIVQQLGLRGSRGGASRTFIHGFRRTNIAIEVRELNPGQRGDAIRDVLAEPENRPAIVYASTRKHAEQLAERLAEEVPTAVYHAGMTPADRDRVQSAFLSGRLEVIVATTAFGMGIDKADVRTVVHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYVDRRTHEFFHQRDYPEPSMLAKLFHAAGAGLEPKEALQARVRMDPEVFDKALEQLWIHGGLEMTPDENVRRGRPEWPAPYTAQRERKMLHLEQMGRYAEASGCRMRHLVSHFGDVQDSGKPCGLCDVCAPETCVTLRFAEPGERELQALGRILDALHERDGQATGRLHRELFGEALPRREFERLIGGMVRAGLTRLSEDSFEKDGQSISFQRLTLTPEGQRTRVIEPDLVMLPMPLEAKSAKKRRATRGKAAGARLEKPRRAGTRGPPVGHSAGSASEGRQRPVAVPWGGTRERAGAVTGRSSKALSVVREWEGMDAPPATEEDWDEEQDIGVRRGGRRQPMPLPKPSPALVEALKAWRLAEARKRRVPAFRILTDRVLGAIAAARPEDREALMAIQGVGPKLVERYGAQLLALVGR
(1289) DNA topoisomerase 1 [Stigmatella aurantiaca DW4/3-1]
1
MATRKKKADETGTEAEETAAKKKAKRPAAKKAAAKKKSATKRKGSASLATVEVSADEEEEATPRGKGPHYLVVVESPAKAKTIKKYLGTGYTVKASVGHVKDLPKSKIGVDVEHDFQPEYQVIKGKEKVLNELKKAAKAVDKVYLATDPDREGEAIAWHIFEELGHKDSYRVLFNEITKKAIQEAIAQPRHLNQESYDSQQTRRILDRLVGYQISPLLWKKIRRGLSAGRVQSVAVRLICEREDEIKAFLPQEYWTLDALLEGASGPPPFKAKLSKIDGKKVELKDRETTDALVAELQGAEFTVAKVDRRERRRNAPAPFITSKLQQEAANRLHFTAKKTMTLAQRLYEGIPMGEEGQTALITYMRTDSTRLSDDAVKQVREFIGNQYGGDFLPEEPVSYRSKKNAQDAHEAIRPVSLEYPPERVRPFFEQMGEQDMFRLYELIWNRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLRVYGAGLTPEEEAEKEKAKAAGDEATDSDEATGELPPLNDGDKLRLQKLLNEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGVMTNEMLVKHFPKEMAVAFTADLEEKLDQISEGGASWKAVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNPLVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVIVEEETTDEKCENCGKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVNCPECKQGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEACPQCQSPYLLQKFSKRDGVYVACPNKECDYRREVQQPADATAPSAA
(1415) DNA topoisomerase 1 [Anaeromyxobacter dehalogenans 2CP-C]
1
MAKEPKTGAVAVKKKKAAAAPKEATAVAEAEAPKTPRRAARKTSTGTSLVVVESPAKAKTIKKYLGRAYDVKASVGHVKDLPKSKIGVDVEKGFLPEYDVIKGKAKVLSEIKRAARTADHVFLATDPDREGEAIAWHISEELGSEGGDARVRRVLFNEITKTAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFVPVEYWSLDADLAAQVPPDFRAKIFKVDGQKADLKQGEETLALVKELEGARYVVASVDRKERKRNPPPPFTTAKLQQEAANRLGFSPKKTMTLAQRLYEGVELGDEGAIGLITYMRTDSVRLATEAVDAVRAHIQQAYGKDHLPEQANVYKTKAKAAQEAHEAVRPTSLEWTPDRVAPFFDQMGERDMYRLYELIWNRFVACQMVPAVYDQTAADIAAGRAVFRATGSILKFPGYLAVYGAKPPEEEAGAEEEKSNGDAAEPAARAEDRQLPPLEAGMELRLLKLLPEQHFTQPPPRFNESSLVKEMEERGIGRPSTYAAILDTIQEKGYVEKLEKQFKPTHLGVLVTDELVRAFPREMDIAFTASMEEKLDEIEEGSAGWQRVLEEFYVSFKEDLAKADEAMRNVKAQAIETDITCEKCGQHKMVIKWGRNGEFLACPGYPECRNTMNFRREDGNIVPEKEEDVPVEDKCPECGADMVMKRGRFGRFLACTRYPDCKGTKPVSIGVTCPKGCGGYISEKRSRRGKTFYGCSSYPKCDFVAWDRPRNETCPQCGSAYLLDKYSKKTGPFVACPNKECGYRREAEPREGGAAAAQVEPAKA
(1071) DNA topoisomerase [Herminiimonas arsenicoxydans]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAATPEAYDEQLKRWSIEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLPMYHSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIVVSLSAGVQAFTAHWVPPNACTDDAGRCLQQPVAQQAMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVTTVLDSLLKTDPSLRSIIGQLDRLQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDHTVAKLSCGGQNLAATGKQVVTPGWRQVLAEPQSEDGDGDGDTAARAQVLPALHEGLACQVADIDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGNASLSIKAPQGPTCPQCGAPTRQRSSKSGPFWSCSRYPDCKGTLPVESGSSKRAASRPRRSGRKGS
(388) DNA topoisomerase [Herminiimonas arsenicoxydans]
5
MTKTLIIAEKPSVANDIAKTLGGFTKHDDYFESDEYVLSSAVGHLVEISVPEEYDVKRGKWSFAHLPMIPPYFALNPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQYAKAKQPIKRLWLQSMTPGAIREAFKNLRSDEEMLSLADAARSRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVRAEFICAAGIYQGRWLDTAFKKDETDPERRPERLWSKAAAESIVAACRGGKPGNVTEESKPTTSMAPALFDLTSLQREANARFGFSAKNTLGLAQALYERHKVLTYPRTDSRHLPEDYLPTVLETLEVVAENNNYHQFAKQILNSKWVKPNKRIFDNTKISDHFAIIPTTLAPKNLSEPEQKLYDLVTRRFMAIFFPAAEFQVTTRFTEVSGHQFKTEGKVMTNPGWLAVYGKEVIDEKDPENSGTLVPVAKGEKVQTESVVANGLVTKPPARYTEATLLSAMEGAGKLIDDSDLRVAMTGKGLGTPATRAAIIEGLLTEKYLLREGREMMPTAKAFQLMTLLRGLGVNELTAPELTGEWEYKLSEMERGKISREEFMREIAQMTQVIVKRAKEYDNDTIPGDYATLKTPCPNCGSVVKENYRRFACTKCEFSMSKTPGSRQFEVAEVEELLTNKTIGPLQGFRSKMGRPFAAVLKISRDEEIKNYKLEFDFGQNDDENAEPVDFSDQTPLGPCPKCAGGVYEMPLSYVCENSVAKPKTCDFRSGRIILQQEILPEQMSKLLNEGKTDLLPGFVSQRTRRAFKAYLVRGKDGKTSFEFEPRKEKVPGKGKAAAVADDAEETTDAAPPKAAKKVAAKKPAAKKTVAKKKPAAKKTAA
(1144) DNA topoisomerase 1 [Anaeromyxobacter sp. Fw109-5]
1
MPRATKAAAAAEGVKAEGVKKEKAAPPKRAAKKVAQGGSLVIVESPAKAKTIKKYLGRSYDVRASVGHVKDLPKSKIGVDVEAGFTPQYDVIKGKAKVLSEIKRAARSAERVYLATDPDREGEAIAFHIAEELGDSGDGRVRRVLFNEITKNAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFKPEEYWTLEAELAAKLPPEFRARLSKVDGQKAELKEGAVTHALVKDLDGATYVVATVDKKERRRNAPPPFTTAKLQQEAANRLGFTAKKTMTLAQKLYEGVELGDEGAVGLITYMRTDSVRLSTEAVDAARGYIAEAYGQDHLPEAPNVYKTKAKAAQEAHEAVRPTSLEWTPARVAPFFEQIGERDMYRLYELIWNRFVACQMVPAVYDQTTADITAGRATFRATGSILKFPGYLAVYGAKPPEDEAGAEEEAKENGDREKANEERQLPPLEAGMILDLRRLLPEQHFTQPPPRFNESSLVKELEQRGIGRPSTYAAILENIQEKGYVEKVERNFKPTHLGLVVTDELVKSFPREMDLAFTAGMEERLDEIEEGNAAWQQVLKDFYDSFKDDLAKAEVNMRDVKRQEIATELTCEKCGKPMVIKWGRMGEFLACSGYPECRNTMNFKRGEDGTIVPEKEEDVPTDEKCPECGAAMVMKRGRFGRFLACTRYPECKGTKPVSIGVSCPKGCGGYISEKRSRRGKTFYGCSSYPGCDFVSWDRPRNEACPQCGSAYLLDKYSKKTGPYVACPNKECGYRRDAEAKAPGAASEA
(171) DNA topoisomerase [Leptothrix cholodnii SP-6]
5
MSKSLVIAEKPSVAQDIVRALTTTSGKFEKHAEHFENDHYVVSSAVGHLVEIRAPEEYDVKRGKWSFNNLPVVPPHFDLEPIDKSKGRLSALVKLIKRKDVTHLINACDAGREGELIFRLIEQYALGAKVGTKPVQRLWLQSMTPQAIRDGFEKLRSDAEMRGLAEAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSIVVEREEKIRKHVSRPYWEVRADFGAAAGLYEGKWFDPKFKKDDDLERRADRLWSEAEADAIAAAVRGRTGTVREEAKPSTQASPLLYDLTTLQREANGRFGFSAKTTLSIAQALYEKHKVLTYPRTDARALPEDYVPVAKETLAMIASEDLPGPLRELAQHARKALDAGYVKPVKRVFDNSKISDHFAIIPTLQAPRSLSEIEAKLYDMVVKRFIAVFYPSAEFMVTTRITEVPVAQSASQSLPKGVTSPLQFQTNGKVLVNPGWLAVYGKDAQDEDANLVPVKPGETVQAEELRISPLKTRPPARYNEATLLSAMEGAGKLIDDEELKAAMQEKGLGTPATRAQVIEGLILEKYMLREGRDLIATAKAFQLMTLLRGLAIEDLTKPELTGQWEYQLSQMEKGQLSRDAFMHGIADMAQRIVKKAKEYDRDTIPGDYATLKAPCPNCGGVVKENYRRFACVGRDANGSSGAEGSGCGFSISKIPGSRSFELHEAEAFLRDHKIGPLEGFRSKAGWPFTAELKLVRDDEINNWKLEFDFGEDAKKDDESGEPVDFSAQTSLGSCPKCKGHVYEHGTSYVCEHAVGAPQTCDFKTGKIILQQPVTHEQMNKLLIEGKTALLDGFVSNKTKRKFKAFLVFDKKEGKVVFEFEPRAARVPAKKAAAKAS
(694) DNA topoisomerase [Methylibium petroleiphilum PM1]
5
MACGTALRSGDNDIENMSKALVIAEKPSVAQDIVRALTPTSGKFEKHDDHFENEHYVVTSAVGHLVEIKAPEEYDVKRGKWSFAHLPVIPPHFDLAPIDKAKSRLNAVVKQVKRKDVGELINACDAGREGELIFRLIVQYAGTEKKPIDKPVRRLWLQSMTPQAIRDGFERLRSDADLRGLADAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSIVVEREEKIRKHVARDYWELKATFAAQAGEYEGKWFDPAWKKNDDAERRADRLWNEADAQAIAQAVRGQPATVTEESKPSTQSSPQLYDLTLLQREANSRFGFSAKTTLSIAQALYEKHKVLTYPRTDSKALPEDYVGVVKQTMEMLAAEDLPGPLKALSAHARKAVKEGYVKPNKRIFDNAKVSDHFAIIPTLQAPKSLTEVEAKLYDLVVKRFLAVFYPPAEFLVTTRISTVKAGSAEHRFQTHGKVMVKPGWLAVYGRDVEDADATLVPVEPGEVVRTESVDVNALKTKPPARYTEATLLSAMESAGKLIDDDELREAMQEKGLGTPATRAQTIEGLILEKYMHRDGRELIPTAKAFQLMTLLRGLQVEELTQPELTGNWEYQLAEMEKGKLSRDAFMREIAAMTQKIVAKAKEYDRDTIPGDYATLKTPCPKCGGVVKENYRRFTCAAKSGDAEGCGFSISKIPGGRSFELDEVESFIADKKIGPLEGFRSKAGWPFTAELKLAYDDEIANWKLEFDFGDDAKKGEGDGTPVDFSAQQSLGACPKCKGHVYEHGSSYVCEHAVGAHVTCDFKSGKIILQQPVAREQMTRLLQEGKTDLLENFVSNKTRRKFKARLAWDAKEGKVGFEFEPRAAKVPAKKSGVRAGTKS
(204) DNA topoisomerase [Methylibium petroleiphilum PM1]
4
MRVFLCEKPSQGKDIARVLGAGQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQYKRWAIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALGALKPSDETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVCVPFWAIEVALSHAGQSFVASWTPPQGSADDADRCLQQPVAQQAAEFLRAAGTAQVLSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLNSLVKTDPSLRPLIERLDRQQRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQFSCGSQSLAAVGKQIAVIGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLKALKTLPPKPYTQGELIKAMKTVAKLVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYLVKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMTLDTFIEKQSVWVGQLVQQYRGATLSLKLPPAPACPQCAAPMQQRTGKSGAFWSCSRYPDCKGTLPIESPTGRRSAPRKRRAASKAS
(1223) DNA topoisomerase [Burkholderia phytofirmans PsJN]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEDYEVKRGKWSFANLPVIPPHFDLNPIAKSESRLKVLTKLLKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTAGSIRDGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCSAGFYEGRWFDPKFKRDEFDPEKRDSRLWALPAAETIVAACRGQIGTVTEESKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKETLGMLKESNNYLPFAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVVGHHFKTEGKVLVEPGWLQVYGREISGEDANLVPVQKDEKVKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLIREGRDLIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACSKCEFSISKIPGGRQFEIPEVEELLQNKTIGPLSGFRSKMGRPFSAILKLSLDDEIKNYKLEFDFGQDAGGEDGEPPDFSDQQPVGACPKCKGRVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKEPSAKTAAKTAAAKSAAKAAPEAESDDGEVSVAVKAAPAAKKAAAKKAPATKTAAAKKAPAKKAAGRKTGS
(900) DNA topoisomerase 1 [Sphingobium sp. SYK-6]
1
MKLVIVESPAKAKTIEKYLGGDYRVLASYGHVRDLPPKDGSVDPEHGFAMAWENYGDKARQLKAITDEAKKADELILATDPDREGEAISWHVQEVLRAKKALPERVERVTFNAITKATITEAMKHPRALDDDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLIVEREREIEAFVSQEYWSVTALLEQGGQRFDARLVRWRGEKLDRLSIGKEGDALAAKADVEAGRFTVSSVETKPATRNPPPPFTTSTLQQEAARKLGLSASETMRVAQQLYEDGAITYMRTDGVQMDESAISAARNAIAKRYDGGYLPDKPRHYQTKAKNAQEAHEAIRPTDFSRESAGSGVHAKLYDLIFKRALASQMASARLERTAVELTDGTGQHVLRATGQVVLFPGFLALYEEGRDDPVGRQGAGDGEDEESRLLPALKAGDQPAKKDVRADQHFTQPPPRYSEASLVKRLEELGIGRPSTYASTIQTLKDRDYVRIEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEEELDEISGGRAQWQQVLEAFWRDFKPKTAEIMEQKPSEITAALDEYLAPMLFPDKGDGSDPRLCPLCHDGRLSLRGGRYGAFIACSNYPECRYTRKFGQPGGADGDAAGGNEELGTHPETGEPILRKSGRFGPYVEMGSGKEAKRASIPKDLPNGELTLDWATRLLSLPRTIGDHPETGKPITASLGRYGPYLAHDGKYARLASTAEIFETGMNAAVAKLADAANRGGARKAAEPLKILGAHPRTEAEIRLMEGRYGPYVTDGTTNATLPKTVAPDALTLEEAAQLIDERAAKAPAGKRKGKAKSSAGKSGAAKKTTVKGKAPSKAKSKAPAAAE
(138) DNA topoisomerase 1 [Sphingobium japonicum UT26S]
1
MQLVIVESPAKAKTIEKYLGGDFHVLASYGHIRDLPPKDGSVDPDNGFAMSWENYGDKGKQLKAIADEAKKATRLILATDPDREGEAISWHVQEVLRAKKALPQKVDRVTFNAITKQAVTEAMAQPRALDEDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIESFVPQEYWSVAAEMEQAGQGFTARLVKWRGEKIERLTIGREGDAMAAKADVEAGRFTVEKVETKPVSRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQQLYEDGAITYMRTDGVQMDGSAISAARKAIAERYDGGYLPEKPRQYQTKAKNAQEAHEAIRPTEFYRDKVGSGDHARLYDLIFKRALASQMASARLERTTVDLVDGTGQHGLRATGQVVIFPGFLALYEEGRDDPERGSGKHASADGEDDDSKLLPRMAAGDAPAKRKVTAEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASTLQVLKDRDYVRIEKNRFFAEESGRLVTAFLERFFERYVSYDFTAGLEEELDDISGGRAQWQAVLEAFWRDFKPKTAEVMEQKPSDITAELDKFLEPMLFPPKADGSNPRACPMCGDGQLSLRGGRFGAFIACSNYPECKYTRKFGQPGGDKDGEDTGPEVLGQHPETGQDIVRKSGRFGPYIEMGEGKEAKRGSIPKDLPDGELTLDWAVKLLSLPREIGPHPETGKPIVANIGRFGPYLLHDGKYGRLSSTAEIFEVGMNSAVAKLADAANRGGRGASSREPLKVLGKHPRTEAEIKLMAGRYGPYVTDGTTNATLPKTIEQDALTLEEAAQLIDARAAAAPAKKGKKAVAKKAGAKKPAAKKAPAKKKVAAE
(1017) DNA topoisomerase 1 [Sphingopyxis alaskensis RB2256]
1
MQLVIVESPAKAKTIEKYLGRDFKVLASYGHVRDLPPKDGSVDPDDGFAMQWQLYPDKAKRLKEISDAAKGADRLILATDPDREGEAISWHVQELLRSKKALPAAVDRVTFNAITKQAVTDAMRHPRELDTDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVEREREIEAFVAQQYWSVTGLFEMGGTPFKARLSRWRGDKIERLSITSEADARAAEADVKAGHFTVDTVETKPLTRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQALYEDGAITYMRTDGVQMDGSAISAARKAIATRYDGGYVPDKPRQYQTKAKNAQEAHEAIRPTDFGKDKVGGGDHARLYELIWKRALASQMASARLERTSVELSDGTGKTTLRATGQVVKFPGFLALYDEGRDDAEDEDARLLPAMAKGDAPAKTGVEVERHETQPPPRYSEASLVKKMEELGIGRPSTYASILQVLKDRDYVRVEKNRFIPEESGRLLTAFLERFFERYVGYDFTAELEEELDDVSGGRAQWQAVLERFWRDFKPRTGEVMEQKPSEITAALDEFLGPYLFPDKSDGSDPRLCPNCGTGRLALRGGKFGPFIACSNYPDCKFTRKFAQSGGNGEADNGPETLGTDPESGLEVTKRSGRFGPYIQLGEGSEAKRSSIPKDIPAEDFDLDYALRLLSLPREVGVHPESGKPIMAGLGRYGPYLLHDGKYAKLGGTAEIFDIGMNAAVVRIAEAANGGGRGRAKAEPLNTFGPHPTSGGEMKLMEGRYGPYVTDGTTNATLPKTTDPATLTMEEAIALIDARAAKGPVKGKKKAAPKKKAAAKKAAAKEAPARKTAAE
(1736) DNA topoisomerase 1 [Desulfovibrio africanus str. Walvis Bay]
1
MAKNLIIVESPAKVKTIKKFLGRDYMVEASVGHVRDLPPNKIGVDEERGFTPDYKVIPGKQKVVAKLKAAADQAEHIYLAPDPDREGEAIAWHVAHLIGDKNKQVSRIQFNEITSRAVKEALDNPRPLDENLFHSQQARRILDRLVGYKLSPLLWSKVKRGISAGRVQSVALRIIVDRERERQAFRPEEYWVFKALLEGPEPPAFAAELWKVEGKKPSVGSGEQAQVLYDRVKDTPFVVSAIEEKERQRHPSPPFITSTLQQDASRRLGYTAKRTMSTAQRLYEGVELGESGVTALITYMRTDSVRVADEARDAAQAFIVETLGADYYPPKPRYFKTKSGAQDAHEAIRPVDVRVTPESVRKHLPADQYKLYTLIWQRFMASQMAAARLHDTTVTVDSGPAQWRAKGERVLFPGFLKVYGVDEATDEKTEGEGGESTSTKAAMLPKLEKGMQLTVRKLTKDQKFTQPPPRYTEASLVKELEEQGIGRPSTYAAIISTLLDRDYARLEEKKFVPSELGVTVVDLLTKHFQSLMDVHFTAGMEEQLDDVAGGKVNWVELLKHFTGDFYPTLDKAKDEMVQVKGGLETGIVCDLCGKPMNIRFGKNGEFLGCSGYPDCKGIKNFTRDEQGQIQIVERANEMPEKVGTCPDCGKDLVLKRSRTGSRFIACSGYPECKHAEPHSTGVTCPREGCTGQLVEKSSKRGKVFYSCSTYPKCNYATWDWPIAKPCPQCDSKILTIKTTKARGEHVACPEKACRFTRELEPDESVG
(262) DNA topoisomerase type IA central domain protein [Desulfovibrio salexigens DSM 2638]
3
MRLFIAEKRDVALAISQALGGPDRPTGAAFQVNGDRITWLWGHVLRLTDPEEHDERYKLWDLNTLPMKWPVTYAPESKHVDHLKKIIELAHQADELVNAGDPDPEGQRLVDEVIEFAGLLEKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAVCDQRYGYNLTRCYSTLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQIDMPSQLVEAEYIPADDAPVDEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPLPYNLLALQADAAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQALTPAFGDMAEYAAPNLKSKAFNSKKVTAHHAIIPTMNVPELGKLNEDERRIYTLIVKLYIAQFYLPAEFVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHKLQQNDSGTVESAESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDESGGIGTPATRDSHIETLFRRGFVAEKSKKVISTELGREFHDALPEFAVKPDMTALWHEKQKQIEAGELNYLQLIEEVDGSVAQEIARVKREGINIKSSAVQCPKCKTGFLKPRKGPKGKFWGCSAYPDCNATFPNKAGKPDLKAKPAKKLAASKEHKCPDCGKGLIRRPAKRKGLFWWSCSGFPECKFRCFDEKGKPKLES
(1384) DNA topoisomerase 1 [Desulfovibrio salexigens DSM 2638]
1
MSKDLIVVESPAKVKTISKFLGRNYQVAASVGHVRDLPKNKLGVEENGDFTPQYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIGWHVAAIIKEVNENVSRIQFNEITARAVKEALEHPQPLNEQLFDSQQARRILDRLVGYKISPILWKKVKRGISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWKVDGKKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDANRRLGYSAKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVILDKYGDEFYPAKPQVYKSKGGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNRFIASQMAPARFWDTVVTIQAKNTIWRSKGERLLFPGFMRVTGKTGDEKLIELPKLEKGEVLKVDKIESEQKFTQPPARYSEASLVRELEEKGIGRPSTYASIISTIQDRGYVNLEEKKFIPTELGFVVSDQLSEHFKELMDVGFTAAMEKQLDDVADGKIEWTSLMKDFVDGFYPTLETAAKEMKRGGEDTGITCDKCESPMVIKFGRTGEFLGCSNYPECKNIVNFTRDEKGKIVVLEEEPPEETGVTCEKCGSAMAIKRSNRGEFLGCTGYPDCRNIKNFERDDEGKIKVVETPTAQIVGKCPDCDDGDLIIKHARTGSRFIACSNYPDCKHAKPFSTGVKCPREGCKGELVEKSSRRGKLFYSCDQYPDCDYAVWYPPIDGPCPKCGHPVLVKKTTRAKGEHIACPEKGCGYVQGEEES
(24) DNA topoisomerase 1 [Desulfurivibrio alkaliphilus AHT2]
1
MGKSLIIVESPAKARTLQKHLGKDYLVKASVGHIRDLPVSSLGVDIDHDFAPQYVTIKGKAKVISDLKKAAKEADQVYLAPDPDREGEAIAYHIAEALKTTRKPIRRVLFHELTHKAVLAALEKSGEVDHHLFEAQQARRVLDRLVGYQISPLLWDKVRRGLSAGRVQSVAVRMVCEREEEIEKFVSEEYWSITTTLAGPQPPPFQALLEKVDGRKLDNRKRKIADEAQARELVLQLMAAELKVAGVDKKQQRRRPSPPFITSTMQMDANRKLRFSAKKTMAQAQRLYEGIDLGKEGPVGLITYMRTDSTRVNDEALGMARDYIGSTYGADYLPAKPVQYKTGKGAQDAHEAIRPTDVSRTPESLAGKLDKDMLALYTLIWKRFVASQMAPAIYDQTSIRIAGGPEGRHELKATGSIMRFPGFMTLYVEAVDETPEEGKQSGKGGKDALLPDLQEGQLLKLNEITPKQHFTQPPPRYTEATLVKALEENGVGRPSTYAAILSTIVDKEYVRLTQRKFYPTDLGRMVNKLLVAHFPKVIDTDFTAKLEQELDEIETGKVDWVQVMREFYGPFQQNLEQAREEMKAVKHSAIPTGLNCPQCESELVIKWGRKGEFLACSNYPECKHTQDFTRDEEGKIKPLEREAPEESGESCDKCGKPMVYKHGRFGKFLACSGYPDCKNVRAISTGVSCPEDGCDGEIVQKVSKRGKVFYSCNRYPKCTYALWDKPVAKPCPLCSSPFLVEKSSKKGRRLACPNKECRYSEELPEEGE
(1362) DNA topoisomerase [Desulfovibrio alaskensis G20]
7
MSKILIIAEKPSVAREIAPLVGAVSRRDGFLEGPTHIVSWAVGHLVNIAEPEEQDEAWGGRWALEQLPMIPRQFRLTVLPEARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRIQLHAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLAAFARAEADWLIGMNLSRLFTLKAGSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGGAAAAAGSAAPVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDVFSAVWHLPPDFKETRLERQDDAEAVIGRCQGGTGVVDATENRKGSQKPPLPFDLTTLQREANSRFGYSAKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHFRAVYHLYPQETVPAVERVKAGCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAPASFMSSTVRVLSGEDVFVARGKVFKDIGWLAVEPWRTAEDNPLPALRKGTRLHVHEVSAVRRQTKAPAHFTDASLLAAMETAGRLVDDEELRNAMKERGLGTPATRAQIIETLLARGYVEKKGKRLIATDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNTYPLFMQEIRTMLAQSVESIKPRNVKNILVETAARLASRELDGKCPLCGAEVEERDKGFGCSRWKRADGGCPFMIWRTFMGTQIDAGMVRELLETGCTSQELQLTSRGGNTFSARLRLEQGRVRPDLPEKHARASGGAAPSAGVDMHDPAENPFFADENPFPPEMP
(493) DNA topoisomerase 1 [Desulfovibrio alaskensis G20]
1
MGKDLIIVESPAKVKTIKKFLGNKYMVQASVGHIRDLPTKELGVDEENDFSPDYQVIQGKQKVVSALREAAAKADNVFLAPDPDREGEAIAWHVAEIIAKENKNISRIQFNEITARAVREALENPRELNRSLFDAQQARRVLDRLVGYKISPILWNKIKRGISAGRVQSVALRLIVDRERERYAFTSEEYWVFRANLAAETPPPFKAELFKVDDKKPAIASAEQAQELEKSIEGKAFIVDSVQEKERSRKPQPPFITSTLQQLASQRLGFSAKRTMSVAQRLYEGLDLGDMGTTALITYMRTDSVRISDEARDSARELIASLYGKEYCPAKAPVYKTKGSAQDAHEAIRPVDVTLTPDKIKGLVAPEQYSLYRLIWSRFMASQMAPARFHDTTVLIGCGGTQWRVKGERLLFPGYMAAAPASAKEANVELPPMQQGQTLELTLLEKEQKFTQPPARYSEASLVREMEEKGIGRPSTYASIISTIVDRDYTRLEEKHFVPTDLGFVVCDMLTNHFGTLMDIGFTAQMENSLDKVAEGDLDWVALMKDFTSDFNPTLASAAKEMKTVKAGLETDIVCSECGKPMAIKFGKAGPFLACTGYPDCKNTSNFTRDESGTIQLVEREQEELKPVGTCPECGKDLVVKQARTGSRFIACTGYPDCKHTEPFSTGVPCPNDGCDGQLVEKSSRRGKIFYSCNRYPQCDYATWNWPVAEACPQCDSKILTIKSTKARGKHIACPACKYTRALEDEE
(1757) DNA topoisomerase 1 [Sideroxydans lithotrophicus ES-1]
1
MATNLLIVESPAKAKTLKKYLGKDFEVLASYGHVRDLIPKTGAVDPDDNFAMKYETIARNAKHVDAIAKAAAEADHIFLAPDPDREGEAIAWHISELLKGKRALKGKTMQRVVFYEITQSAVREAVAHPREISIPLVNAQQARRALDYLVGFNLSPLLWRKIRPGLSAGRVQSPALRLIVERELEIEKFKSQEYWSVHLDSQKNSIPFKAKLYQFQGKRMEQLTIGSQAEYDAIHAKLVDAKLPPKVVRVEKKGKQRSPAAPFTTSTLQQEAVRKLGMTSDRTMRTAQSLYEGVDIGGQTIGLITYMRTDSVNLANEAVAEMREYIKDNFAGDYLPVKQPVYKSKSKNAQEAHEAIRPTSILRTPDSLRDHLNIDQMRLYEMIWKRTLASQMSPARFDTVSVDIRLSSDDTLFRASGQTLVFPGFIGVYMEDVDDAEEEDSAKLPPLVEGDVLPVDKLYGEQHFTQPPPRFSEASLVKALEEYGIGRPSTYATIISTLQAREYATLDKKRFMPTDVGRVVIKFLNEHFTRYVDYGFTANLEDELDDISEGKRDWIPVLNEFWKGFNKLISEKKDVDRPGTEILEETCPKCGKPLSKRLGKRGSFIGCTGYPECDYTRSLGGEEDAGESRKELGQHPDTNQLVLLLRGPYGPYVQLGEMIEGEKTKPKRVSWPKELPLEQADLPSALKLLSLPREVGAHPETGKKVIVNIGRFGPYIGHDGKFKSIPRTDSIFDIGLDRSVELLAQARSGGATVLRTLGEHPDDKAPIEVCSGRYGPYVRHGKINATLPKDVTPEAVTLEEALEMIAAKAAKGGTGKAKTTRKPAAKKAAAKPKTTKEKAAAKPKTTVKKATVKTATAKTTVRKVAAKPAAKKTTKK
(688) DNA topoisomerase [Candidatus Accumulibacter phosphatis clade IIA str. UW-1]
5
MSKKLIITEKPSVAADVARALGGFVRHDDYYEGDEYVLSSAIGHLLELACPEEYEVKRGKWSFAHLPVIPPHFALQPIAKTESRLKLLVRLIKRKDVAGLINACDAGREGELIFNYINQHAGNAKPVERLWLQSMTPQAIREGFSRLRSGTEMQGLGDAAVCRSESDWLVGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLALMVDREDRIRKFVARAYWELDGVFACAAGDYRGRWFDENFKGKDDDEHARADRLWDESRALALQNKCADQDGDVSEESKASTQLSPLLFDLTSLQREANGRFGFSAKATLGLAQALYEKHKILTYPRTDSRALPEDYRQTVLSTLSMLTGEGVGKGHDEQTLARYAPFAGRILASNWVVPNKRIFNNAKVSDHFAIIPTLQAPKHLSEPEMKLYDMVVKRFLAVFHPAAEYLITTRITRVAGEPFKTEGKVLVNPGWLAVYGREGQEGEEGNLVAVQAGERVHASEMLLSAHQTRPPARYSEASLLTAMEGAGKAMDDEELRAAMAGRGLGTPATRAQIIENLLAEQYLQREGRELQPTAKAFSLMTLLNGLGIPELTAPELTGEWEWKLARMERGELARTAFMKEIAAMTQRIVDRAKSYDSDTIPGDFGELSTPCPKCGALIKETYKKFQCQACDFSLWKIVAGRQFEASEIEELLTRRRIGPLSGFRNKMGRPFNAIIQLNADNSPEFDFGQGSAGADGPAEEVDFSQSETLGPCPKCGASVFEHGMAYVCERSQGSAKTCDFRSGKVILQQTVEAEQMQKLLSSGRTDLLRNFVSARTRRKFSAYLVRGADGKVGFEFEKREPRTPAKKSRATPTSEPSDAATPTSGTTTRSRKKASSS
(154) DNA topoisomerase 1 [Desulfovibrio magneticus RS-1]
1
MGKDLIIVESPAKVKTIKKFLGNAYAVEASVGHVRDLPSKKLGVDEKDDFAPQYQIIPGKQKVVSKLKEAAASASTIYLAPDPDREGEAIAWHVAQIVQEAGVPVHRIQFNEITAKAVREALSHPRDINEKLFLSQQARRILDRLVGYKVSPILWQKVKSGISAGRVQSVALRLVVDREKERRAFVPVEYWNFKARLAADSPPEFEAELAKYQGKKLEIGSAEAAAAAEAAITGQPFVVTAVTEKERKKSPPPPFITSTLQQAANQRLGYSAKRTMGAAQKLYEGLELGDSGTVALITYMRTDSTRIADEARDAAREYITEALGPDYYPEKARHFRSKAGAQDAHEAIRPIDVRITPADVKTLLPKDLFSLYKLIWERFVASQMAEARFWDTAVDVTAGPGLFKAKGQRLIFPGYLKVYGQEAGDEAKSLPKLDKGQELTLLELKKEQKFTQPPPRYTEASLVRELEEKGIGRPSTYAAIISTLIDRDYARLEEKHFVPSELGETVSDLLAEHFVKIMDVGFTAGMEEALDAVADGRTDWVNLLKDFTEDFNPTLAKAAKDMAKVKAGKETDVKCELCGKPMVIRFGKAGEFLGCSGYPDCKNTKEFDRAPDGAVIPRERKAEEVASVGACPTCGKDLVVKKSRTGSRFIACTGWPDCKYTKPLSTGVPCPKEGCSGTLVEKSSKRGKVFYACDAYPQCDFAVWDWPINEPCPQCDSKILVRKKTRDGELITCPSKSCRYKRAVGGKKDEGEGEE
(1863) DNA topoisomerase 1 [Campylobacter lari RM2100]
1
MKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDENFKPEYRISSDHSTLVKELKEKAKNAKQIYLATDEDREGEAIAYHIAKAINKDENSLPRIVFHEITKSAIENALNNPRHLDINSVNAQQARRLLDRIVGYKLSPLLNQKIQKGLSAGRVQSAALKIIVDREREIKAFTPLKYFSIDVIFKKDLEAELVEFQGQKIEKFTITNEDRAKLIFENCKNAKFKINNIESKDRKITPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVKTHQGIMGVITYMRTDSLNIAKEALEQVRKLIKDEFGKEYLPAKANIYTTKAKGAQEAHEAIRPTNLSFTPKLASEFLEKDEARLYTLIYNRFLASQMNPAISQTQNVYAKSNEASFKISGRKILFDGHYKVYGDMDKDKILPNLKLEDTLNIQNIEFNSHFTEPPSRYSEAGLVKKLENLGIGRPSTYAPTISLLSARDYVRIDKKQLIPNEIAFNVIEVLEQNFSDIVDSDFTFKMEESLDEIAEGKLDWQELLREFYFPFMRKIDEGKKNIKSQKTITKIDETCPDCGGELAIRKGRYGEFIACLNFPKCKYSRNLKQENKNEEKTQIKQVNSIGLTCPECKKGEIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGENLIIKELKKGTFLECLKCKIKKEI
(553) DNA topoisomerase 1 [Desulfomicrobium baculatum DSM 4028]
1
MGKDLIIVESPAKIKTIKKFLGGGYEVEASVGHVRDLPTKTLGVDEGNDFAPDYQIIPGKAKVVSKLKSAAKAADTVYLAPDPDREGEAIAWHVAEVIRTSNPNVKRIQFNEITAKAVKEALANPTELRKPLFDSQQARRILDRLVGYKISPLLWKKVKRGLSAGRVQSVALRLIVDRERERQAFVSEEYWVFKITVQGETPPPFDADLWKVDGEKPVIGDEKTALALESRVDGQSYVVRDIVEKERQRHPRPPFITSTLQQDASNKLGFNAKRTMSVAQRLYEGVELGERGTTALITYMRTDSVRISDEAKDGAREWITRTLGPEFYPKEPRVYKSKGSAQDAHEAIRPVDPSLTPDSIKNNLPPEQYKLYRLIWERFMASQMASARFWDTVATIESGPAQWRAKGERLVFPGFLQIWPQSSDNQSALLPKLVTGQELRLEKLHKEQKFTQPPARFSEASLVHKLEELGIGRPSTYAAIISTLTERDYVHIEEKHFQPTDLGVIVCDLLVEHFAHLMDAGFTARMEESLDHVAEGETDWVALLRDFTLDFNPTLDKARENMTQVKAGMDTGLSCPQCEDGRLVVKFGKNGTFLGCANYPACSFTSNYIRNNAGEIELVKEEAPEELGPCPKCEDGRLVVKKTKTGGRFVACSNYPACRHTKSVSTGVACPKDGCDGELVEKTSRRGKPFYSCSKYPKCDYAVWDFPVAKPCPLCESKILVRKETKARGAHLACPVKDCGYWEKLD
(1398) DNA topoisomerase [Desulfomicrobium baculatum DSM 4028]
7
MPRTLIIAEKPSVARELAGVLGVKGRGDGFLQGPGHIVTWAVGHLVNIAEPAEQNPAWSGRWSMRQLPMLPSRFTLGILPSTAKQYEIIRNFLLDDDIDSVVNATDAGREGELIFRRIYLLAGSTKPIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAAFARAEADWLVGMNFSRLFTLRAGSLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGEFAHEGETFKATWFAAPDFKDSKIWQVEEGQTVVQACAGKDGAVLEMEKKKGRQKPPLLFDLTNLQKEANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVYAHFPEISQSAAANIKDAKKKFECVNDKKVSDHHAIIPTTLRANPATLGKEEWAIYEMICRRFAAAFMDDATFASSTLWIGVEGHRYRATGKIFQDKGWLEAEPWRASEDNPLPNLRKGAAVTAQSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKERGLGTPATRAQIIETLLARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVASPELTGEWEKRLKEMEQGGYAYGVFMHQVREMVSSGVSRVKGSNARPPACPVVSDRKPSKEVNS
(1558) DNA topoisomerase 1 [Bdellovibrio bacteriovorus HD100]
1
MAKKSDATDGIKLVIVESPTKAKTIRKFLGRDYVVESCMGHIRDLPQSAKDIPEKVKKEKWAQLGVNVDKNFEPLYCVPKDKTKVVKNLKDKLEEASELYLATDEDREGESISWHLLEVLKPKVPTKRMVFHEITKDAIQKALKDTREIDFNLVRAQEARRVLDRLVGYTISPLLWKKVAYGLSAGRVQSVAVRLIVERELERVRFKKSSYWGVLAELSKDGVSFESRLQQYKNQRVATGKDFDGLTGQLTAGKDVLVLDEKTAGKLSMDLKSGNWQVTDVEEKPTFRKPAPPFITSTLQQESNRKLGLSSRETMQVAQKLYEQGFITYMRTDSTFLSNEAITASRDCIESKYGKEYLTPQPRNYAAKKVKGAQEAHEAIRPAGNQFMDPDETGLTGTQFRLYDLIWKRTIASQMVDARQKQVSAKITVGDALFGASGMTIEFPGFLRAYVEGSDDPEADLAEREVRLPALKVKDGVKCAKLDPTSHETKPPARYTEASLVQTMEKEGIGRPSTYASVIGTIIDRGYVRKNGTALVPTFTAMIVSKLLSQYLSQYVDLGFTSEMEQSLDNIADGELDWESYLASVYKGPKGLRAMVDNQGDKIDPNEARTMTLEGMDKYKFHVGRYGAYVTTQRDGEDVSASLPDNESPADITPEIAEKLIDQKINGADSLGNDPETDLPVYVLNGRYGPYVQLGDVTPEDDKPKRASLPPGTQPEQVDLAMALSLLQLPKTLGTHPGTGKDIKAGLGRFGPFVVHDGDYRSIPKGESIFNITFEKAMEMLAQPKKGRGRAAPLKELGAHPDSGDAIQVFNGPYGPYIKCGKVNASLPEGATPDTVTLEQAVALINEKGPAKGKGKAKGKAKAAPKAKAAKADGEKPAAKKPALKKAANAKEKAEALGVKKVVTRKSKK
(1499) DNA topoisomerase 1 [Bacteriovorax marinus SJ]
1
MKRASPFHLNKDVIMASSEAVEETKSSKKTAKKTAKASSKKKTTKKKTTTSKKKTAKKKTAKTTKKKTTKKRDLGDYSLVIVESPSKAKTIKKYLGKGYQVVASNGHIKDLPKSKLGVDIKENFQIDLVPITGKKDKIERIQELAKDATAIYLAPDMDREGEAIAHHLAEEIGKKKKMYRVVFNAVTKSAVNNAIENPTELNKSMYESQQTRRILDRLVGYKISPILWDKVQRGISAGRVQSVALRIIVEREDEINAFEPEQWFSIHGVCEKDAQKFEVKYYGESATKKTDLTEKDLVDKILSDVKGKSLDVIDVKKKERKQNPTPPFTTSKLQQEAANKLGFTAKRTMMTAQKLYEGIQLTEHGMQGLITYMRTDSVRTAPEAMGALREFILDKYGKDYLSVEPIEYKKKGSSKVQDAHEAIRPTNLAFTPDSVRGDLEPDQQKLYELIWNKFISSQMSQAIIDQTTVMMEREGHFFKANGSIIKFPGFRTVYLEAAAEKRSRKGGDDEDDNDAGEVKSGLLPVINTGESFTPIEGPTEQEHWTSPPPRFNEASLVKSLEEFGIGRPSTYAAIISNIQDRGYVEKTENRFLPTELGIVVCRMLVESFPNVMDIKFTAGVEELLDQIEDGTIKYKKVLKEFWKEFEVTLEKAKEEMKNLKKQLIPTGINCLKCEDGEYHIKWGRNGQFFACSNYPDCNSTQDFKKHLDGSYEILPKNWFHDNCPNCQKRLEVKKGKYGRFVRCEDYPQCDTTLPYTLDITCPECNVGKFAEKKSRYGKIFYGCSNYPNCENASWTKPYVQDCPSCGYGIMGFKETKRDGKHLECAKCKFKLEWEQTKYGKEELEKQRQEEEALKGSH
(1533) DNA topoisomerase 1 [Geobacter daltonii FRC-32]
1
MPQHLVIVESPAKAKTIEKFLGPDYKVLASFGHVRALPSKQGSVDIEHDFEPKYAVLPESKKHIDAIKKELKQADVLLLATDPDREGEAISWHLLAALGLDKKPNIDIKRVVFHEITKGAIVNAVENPRGISHELVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFVEQEYWTIGADLSTAGKQNFTANLVEADGKKLGKFDIPGKEAADKLIEILDKATYSVEKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSIAQKLYEGIDIGEGTIGLITYMRTDSVVLSQQALDEAHQVITSLYGKEYALAKPRVFKNKAKNAQEAHEAIRPTYISKTPVELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVEISAGKGYKFRVAGTVIRFPGFMKLYIEGVDDETEEKEGVLPPLNEGDSLQLRDLLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYARLDKKRFFPEDVGMVVSELLVNHFTKYVDYNFTASLEEELDQVSRGEKKWKPLLHEFWQPFHNLLKQKEGEVNKSDLTTEATDEICPECGKPLVVKLGKFGKFFACSGYPECKYIRPLDKDKKESAEPVFSEEKCEKCGSQMLIKEGRFGKYLACSAYPACKNMQPLVKPKGTGIKCVECGEGELTEKKSRYGKMFYSCNRYPQCKFALWDLPVEKPCPKCGFPLLVKKVYKREGEFLKCPKDGCDYKEGGKEK
(1416) DNA topoisomerase 1 [Desulfococcus oleovorans Hxd3]
1
MNKPVIIVESPTKVKTITKYTGNAYSVTATSGHLRDLPPHELGIDIDNGFAPDYVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIAFHVADLLKKKGRRFHRVMFHELTKTGIQKGLTEPTELNRNRYDAQQARRILDRLVGYQISPLLWRKVRNGLSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVKKGTKNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAIRKLGFTAKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPEAAHEALAHIRSVFGNDYAPDRPRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKRFVASQMSEAQIDQKTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDKLPQLDEKEVLKLIELDPKQHFTTPPPRFSEASLVKELEENGIGRPSTYATILSTIRDKGYVDLINKAFRPTELGFIVNDLLVENFPTILDIEFTANMENDLDRIESDQLQAVRLLERFYGPFSQRIEAAKDRMRSVKGVGMDTGLSCPECGKELKIKLGKNGPFLACSGYPDCKFSRNYARTDKGTVEPVEPDLTVAEGKSCEKCGSPMVVKQGRYGDFLACSAYPDCKSTQSLNSGANAAPIGVKCPEPGCNGDIVEKKSKRGKVFYGCSRFPKCTFASWDKPVDMACPDCGAPFVVEKTTKKEGTVLTCASEGCGFRQRT
(72) DNA topoisomerase [Desulfobulbus propionicus DSM 2032]
7
MGKTLIIAEKPSVAADIVKALPGKFTNAKTHYESDEYIVSYAIGHLVSIAYPEEINPELNKWTLDNLPILPEEFPLAVLPDTKAQFNALTKLIRRRDVEVIVNGCDAGREGELIFKYILKQATNRSVEHKRVQRLWLQSMTLDAIRDGLGKLKDDQEMRPLEDTALCRSEADWLIGINATRALTCYNSRFGGFRKTPCGRVQTPTLSLLVKRETERREFVPTTYWELHGCFVCGPVAYQGVWIDPAFAKDEEQAHGRRNRIWEEERAKEIADRCTGKPAMVEESSKKSTKGAPPLYDLTLLQREANSRFGFSAKNTLALAQALYERHKLITYPRTDSRCLPEDYLPTVVKVVGQQQQWQYGRFASEALEKKYLKKDKRIFDNKKISDHFAIIPTAGLPKTLSEPELKIYQMIVQRFLAVFFPAAVYHNTRRLSLVEGETFLTEGKILVEPGWRAIYGASSEEDGDKELQALPPDTLVQCEDIDRQEHQTKPPPRFTEATLLSAMEHSGKLVEDEELAEAMKERGLGTPATRAAIIEKLINEKYIVREQRELVPTGKAFELLSLLEARKIDVLASPELTGEWEYKLNQILKGAMTRTQFMKEIREMTGAIVDKVKQGGGTERHEAPFSPVDGARFYETASAYESEDKKLIIRKVLGGRVMDPAEIVELIRGKTLGPFNDFRSKKGKPFTASVHIANSKVEFLFADSTDELNLDEIRGQEPLGLSPVDQTKVFETPAGFLSESALEGDQKKGLRISKIILGKKLEREHISQLLADGRTELIGGFISKRKKPFDAFLLLDAKGKLSFAFPPRGKKGKDKEADNG
(1500) DNA topoisomerase 1 [Syntrophobacter fumaroxidans MPOB]
1
MSKSLLIVESPTKAKTLGRYLGKDFIVKASVGHVKDLPKNRLGINLEKDFQPEYQVIRGKKKVISELHEAAAKSGAIFLGPDPDREGEAIAWHIAEEIGATDKPVYRVLFYELTRKAIQEALAKPDRLNRELYEAQQARRILDRLVGYMISPILWQKVKRGLSAGRVQSVALRLICAREKEIRDFDSREYWTITALLGTQASADAPAKSASRRFKAELFRCGKKKCTISTGEEARELVDRLRPLDYRVSKVERRKKKRHPAPPFITSTLQQEAARKLHFSARQTMNVAQRLYEGLELGKEGAVGLITYMRTDSTRLSADAVQAVRDYIAGHWDKAYLPAKPAAYKSKAGAQGAHEAIRPTDVNRTPETVAGFLTKEQLKLYTLIWKRFTACQMAPAVLDQTSVDIAAGDYVLRASGSIVEFPGFMTLYVEGRENGDEDSETEGLLPELKEGEVLRLEDLKADQHFTQPPPRYTEASLIKELEDLGIGRPSTYATILSTILDREYAVVRKKSLFPSELGWLIDGLMVENFPSVVDVDFTAKMEKSLDEIEQGQHPYRNLLAEFYEQFSKTLESARTNMVNLKAVGRRTDLQCPQCGLPLHIRWSRNGPFLACSGYPDCRFSSDYRRDEKGNIEPVAEESTGETCEKCGRPMILKKGRFGNFLACSGYPACKNTKAPGTGIPCPREGCSGELVERVSRGGRHFFGCSRYPECKTAFSGRPVPGKCPSCGTGPLIEKGGKGGSVKRVCVNPSCKYVETVPAAADRKAAKD
(61) DNA topoisomerase 1 [Lawsonia intracellularis PHE/MN1-00]
1
MGKNLIIVESPAKVKTIKKFLGSGYVVQSSVGHIRDLPKKNIGVDESKNFSPHYEIIPGKEKIVQGLRETAAKVDTVYLAPDPDREGEAIAWHVAELIKDKNSNIQRIQFNEITSKAVQEALSHPQKLNKNLFDAQQARRILDRLVGYKISPLLWKKVKQGISAGRVQSVALRLIVERDEERYTFIPEEYWLFKANLEGSNPPPFKVELWKVNNKKPIIPDAVTAAALEQQIKDKPFIVDSIEEKERQRSPKPPFITSTLQQAANQRLGYTAKRTMNIAQRLYEGLELGDKGTTALITYMRTDSVRIANEAKLAAATLIEQKFGKEYLAKGGNGRNFKGKAGIQDAHEAIRPIDVTILPEDVKPYLAPDQYQIYRLIWSRFIASQMSVAQFHDTIITINCENSQWRTKGERLLFPGFLAAFPNTKEEEDTNLPVLHKGEILKLHSLIKEQKFTQPPPQFTEASLVRELEELGIGRPSTYASIISTLQDRDYVRLEDKHFIATDLGRVVCMLLQDYFKNLMDVTFTAHMEELLDKVAEGKQDWVELLQNFSETFNPTLEEATKAMSQVKTGLETDINCPDCKKPLVIKFGKSGQFLACSGYPQCKFTSNYLRDDKGQIHLQEKVQPELQKIGICPKCNKDLVLKKARTGSRFIACSGYPECNYTEAFSTNVPCPCEGCKGMLVEKSSKKGKVFYACNTYPTCDYAIWNWPIQKSCPTCSFPILVEKITKAKGKHLACPEKNCRYTCELEESDIET
(409) DNA topoisomerase 1 [Sulfurovum sp. NBC37-1]
1
MKNLIIVESPAKARTITSFLGKDYKVIASKGHIRDLPKSTFGITIDDETGDLIPKYSIPRDANPTVKELKKLAKEAETIYIATDEDREGEAIGYHIAKAIGKEPTELPRIVFHEITKSAIQHALENPRKVDMDSVDAQQTRRLLDRIVGYKLSPLLASKIQKGLSAGRVQSSTLKIVVDREREIKAFKPEEYWTIDALFEKNIDASIYDYNGLKIDKLTIKTDADANEIVESAKGESFVVSSIEKTKRKTKTPPPFMTSTLQQAASTQLGFSPKKTMMVAQKLYEGVKTDKGTMGIITYMRTDSLNLAKEAVEAARTHIKETYGDKYLPAKAKHYTSKSKGAQEAHEAIRPTRVDFDGTKAANFLNADELKLYRLIYNRFLACQMTEAELESQTILFKGDKCTFKASGRKLLFDGFYRVTGYNEKDKLLPELKKEQPVSLDDIKAEQHFTEPPARYNEASLIKKLESLGIGRPSTYAPTITILQTRKYIEIEKKRIHPTEIAFTVIEMLEKHFPEIVDSGFTANMEETLDKVAEGETDWQTILKEFYTPFLQKIEEGKKNIKSLKVAIPTGENCPKCGSELLLRKGRYGEFIACSNFPKCKYTKNTDGTEVEQPEETDEKCEKCGSPMVIKNSKRGKFLACSAYPKCKNAKSLTPPKELSVPCPECGGKLQEREGRRGKFFGCENYPKCKFIANFEPVDKKCPECGYTMGKKTLRGKEIFECFKCKHKEEAK
(309) DNA topoisomerase 1 [Pelobacter propionicus DSM 2379]
1
MPQNLVIVESPAKAKTIEKFLGKDYKVLASFGHVRALPSKQGSVDIEQDFTPKYHILPESKKHIDAIKAALKDAKNLLLATDPDREGEAISWHLLAALGLDKKNPGKSIQRVVFHEITKDAIIHAVENPRDIATDLVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFKEQEYWTIAARLGVKPGAEFRASLVEVGGKKLGKFDIPDENVATALNRALKSGSYRVAKITRTERKRNPSPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGIDIGQEGTVGLITYMRTDSVTLSSQALTEAHEVISAAYGAEYALAKPRIFKTKTKNAQEAHEAVRPTSIARTPAELKKHLTPDLFKLYELIWKRTVASQMAEALLDQTSVDIAAELNEAVADCTVAESGAASPFTGAKRCGLRAAGTVIRFPGFMKLYIEGLDDQDEEKEGLLPPLQEGDDLKLHELFPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYTRLDKKRFFPEDVGMVVNDLLVAHFSRYVDYNFTAGLEEELDQVSRGEKQWKPLLKEFWEPFITLLKQKEGEVKKDDLTTTELDEVCPECGKPLAIKLGKRGKFIACTGFKEGCTYTRNLESDASEPSEPVLSDEKCDKCGQQMLIKDGRYGKYLACSGYPACKNIQPLVKPRGTGVVCPECKEGELTEKKSRFGKLFYSCNRYPQCKFALWDPPVEQPCPKCGFPLLVKKVYKRKGEFLKCPKEGCDYTSE
(426) DNA topoisomerase 1 [Desulfatibacillum alkenivorans AK-01]
1
MSKPLVIVESPTKVRTVKKYLGNDYNVAATVGHVRDLPQKNIGIDIDNNFEPQYEVIPGKQKVISNLKKLAKDASEIYLAPDPDREGEAIAWHTAQLLQGKNRRFHRVLFHELTKNAILNSMQNPLELDKSKFEAQQIRRILDRLVGYQVSPLLWKKVQRGLSAGRVQTVAVRMICEREREIQAFDPEEYWSITAHLQKDEPPVFPAKLLKIGDKKAKVSNEEEANAVLKELEGETYVVDRVIKKTVKRNPLPPFTTSKLQQDSIHKLRFSAKKTMLLAQQLYEGIDLGPGEPVGLITYMRTDSTRVSNEAALEALDYIGKVYGPEYRPDKPRFFQNKKKVQDAHEAIRPTNVLRTPNQVSDVLSKDQLALYTLIWQRFVASQMNPALFDQTSVSVKAGRYLFHATGSTLKFKGYLMVYDAGDGDKDDNKIMLPVLEEKMILQCNKLEPKQHFTQPPPRFSEASLVKELEENGIGRPSTYAAILSTIRDKGYVDLVKRYFRPSELGFIVNDLLVSSFGDIFEVPFTAQMEDNLDKVETSQANSLEILNAFYNSFKQDLENAGDKMVSVKGVGVPTGIKCPQCEKELHIKIGKNGPFLACSGYPECRFTRNYDRDDKGGIVMETPPETEETDEVCDKCGKPMLVKSGPYGTFLGCSGYPDCKNTKTMNGGAQQNQATGIKCPVEGCDGEIHERRSKRGKVFYGCSKYPKCDFATWDKPVDKPCPVCQSPYLVEKSTKKSGVYLKCPTRGCKYREDPQ
(497) DNA topoisomerase 1 [Geobacter bemidjiensis Bem]
1
MSQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPESKKHIDAIKKEMKGISSLLLATDPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITKDAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKLGGKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQLLPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFTQYVDYNFTANLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVNKSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEEICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFGKLFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS
(359) DNA topoisomerase 1 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]
1
MKKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKNPRKLNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDREKEIRAFVPLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSISDIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIAAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGRKILFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISILTSRDYVTIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIAEDKADWQETLKEFYYPFMRKIEEGKTKIASQKTVTKLGESCPDCGGELAIRKGRFGEFVACLNFPKCKYSRNLKSESKNESENTAAKAKANGTGITCPSCQKGEIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGETLVIKELKKGTFLECLKCKIKKEMKD
(123) DNA topoisomerase 1 [Campylobacter concisus 13826]
1
MKSLIIVESPAKAKTIKNFLDKSYNVIASKGHIRDLPKTSFGIKIEDDKFTPEYRISSDHSAIVKEIKELAKGADEIYLATDEDREGEAIAFHIANAIGKEPTSLPRIVFHEITKSAIQNALKSPRHVDMNSVNAQQTRRLLDRIVGYKLSPLLNLKIQKGLSAGRVQSAALKIIVDREREIQAFKPVEYYTIDTVFKKDLDAELVKFENQKIEKLTIQNPDRAKYIIENLQNEKFSVREIESKDRKIQPSPPFMTSTLQQSASNRLGFSPKKTMMIAQSLYEGVQTNEGFMGAITYMRTDSLNLAKEAVAAAREHILQNYGKEYLPAKAISYTTSSKGAQEAHEAIRPTNLNFTPQIAAKFLEKDALKLYTLIYNRFLACQMSACVSQTQNVYVASEKGEFKISGRKVLFDGFYKVYGELDKDKILPNLKKGDEMSLQSIKSTQNFTEPPARYSEAGLVKKLESLGIGRPSTYAPTISLLTSRDYVRIEKKQLIPNEIAFSMIGVLEEHFSNIVDSEFTSHLEEKLDEIALDKADWQKVLSDFYYPFMEKISAGKTGIKSLKTATPIGEKCPECGSELVLRKGRYGEFIACSNFPKCKYSRNVAKDNEKSAETGSTTAAKPKRELKKLDVPCPKCGGEIVERFSRRGKFYGCANYPKCDFISNYEPVAQKCDECGGDMIKKELKKGTFIECTKCKKKTLVSEN
(596) Reverse gyrase [Nautilia profundicola AmH]
6
MLHIIYKNECPRCGGDISSVNLNKGMFCDECMKSKKKEWNLENCENLLNYEKYCIADKKVNEFNEFFKFKCGNELNSIQKMWAKRFFLDNSFALLASTGIGKTTFGLLLSAFVKNSYILFPTKLLVAQAAEKYKKWGIEFVAYMGKKSEKELIEKGEYDILITTTQFLYKNRSLIKRNFELIFVDDVDSILKSGKKIADILTLLGIDKNSIEKTYELIKNQKYSEIKSVSKKGNLIVSSATANPKSKKILLFKYLLGFEVSRPNFNLRNIEDLYDENYSWDHSVKWINELGRGGLLFLPGNETKDTLYEYIDFLNTKNIKAYSYEDFEKHLEEFKEGKCFFVGFASYKNPLARGIDLPEYIKYTLFVGVPKIEFNLKDENFRAFYFIMLSLLPYLVKNNLSQKEVSEIQNDLNYLKKYIYLSKINVNTQQKIADILIRFKNTVKKYEDIIKTAENISFDGEKFIIADVTGYIQASGRSSRFYKGHLTKGLSLLLVDNKKAFYSLKKKLKWFGEIEFKNVEDVDIKKVLTEIEKSRTENVKTEFKTSFVIVESPTKAKTISSFFGNPSKRIINNVAVYEVLSQDRVLIIAASIGHDFDLVKDEGVWGVKDLIPIFHVLENKDKILQTLNINANEVEEVYAATDPDREGEKIAFDLTMINKPYNMNIKRIEFHEITKQAFEEALSIPREIDLNLVKSQLFRRITDRWVGFKISLYLQRLLNNTHLSAGRVQTPVLKWICERTGLLKEKIYVVIIRFNNVSIDFEFDTKQEANEFFNSLKESVYIKKLSSNTEVMFEKPFNTPDLLKEASNKLRFSPQKTMQLAQELFEKGFITYHRTDSYRISDTGKAIAKTYILENFSKDYLKFRNFESKGAHEAIRATTSMDADELRSYMLERNILLSEEHLRLYDLIFRKFIASQMKEAKVLKEKFLILLKEKSFITEIVENGYNLIYPINIYIISEGENKIVKELRQKPKAAPYTYAEVIEEMRSKGIGRPSTYAIIIEKLLKRKYITDKNGYLFATKLGFRIIKEVYKSDFKDFVSEEFTAELENIMDKIEEGKTEYEKELKKLFSLLF
(705) DNA topoisomerase 1 [Nautilia profundicola AmH]
1
MAKNLIIVESPAKARTIKNFLGKEYEVVASKGHIRDLPKTSFGIKIEEDKFIPQYRVTADHQPIAKELKEKAKKAETIYIATDEDREGEAIGYHIAHVIGKKPEELPRIVFHEITKTAIKKALENPRTIDLNRVNAQQARRLLDRIVGYKLSPLLNKKIQKGLSAGRVQSAALKLVVDREREIKAFKPQEYWSIEGIFKKIEGSLIKYNGKKLDKFDIKSKDEAQKIVEELKPLEYTVREIETKTTTVKSPAPFMTSTLQQVASSELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQQAALEFIKQNIGEEYAQAKTYATKNQNAQEAHEAIRPVDVRLTPDDLKNYLKPDELKLYALIFNRFLASQMKDAKFETQNIYIANDKGEFKISGRKLIFDGFYKVYGKPSANTLLPEFEKGEKLKPEDVKATQHFTKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEVKDKKLHPTEIAFSVIETLEKHFPDIVDANFTANMEEMLDEVAEAKKDWQEVLKDFYNPFMELVNKGYKEIPSQKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYPKCKYTRPLEESKEEKKTDVKCDKCGADMVVKKGKSGEFLACSNYPKCKNTKPLNAPEVLDDVKCPECGGDIVKRKSRRGEFYGCANYPKCNFISKYRPVNKKCPECGYLMAERTYRKKDVYECIKCKHREEAKK
(997) DNA topoisomerase 1 [Sulfuricurvum kujiense DSM 16994]
1
MKLIIVESPAKAKTIKNFLSKDYEVIASKGHIRDLPKNRFGIKIDDEKIIAEYRISEDSTATVKQIQELAKKSDTIYIATDEDREGEAIGWHIAHAIDKDPSSLPRIVFHEITKNAIIHALETPRTIDMDRVNAQQARRLLDRIVGYKLSPLLANKIQKGLSAGRVQSSTLKIVVDREREIRAFIPEEYWTIDTLFKKDIEAALVNFENEKIDKLTIKTGDEAARIVETLKGESFKVGEIETKERKSSTPPPFMTSTLQQTASSQLGFSPKKTMMVAQALYEGVKTPEGTSGVITYMRTDSLNLATEAVEAAREVILTRYGKEYLPKEAKVYTKKSKGAQEAHEAIRPTMLGFTPEVAATYLKPDEIKLYRLIYNRFLACQMNDARFEQQSITFESAKAQFRATGRKLLFDGFYRVTGSDDKDKLLPSLTTGDSIEIQTVTPEQHFTEPPARYSEASLIKKLESEGIGRPSTYAPTISTLQARNYIEIEKRAIMPTEIAFTVTEMLENHFNEIVDASFTATMEETLDEISESGKSWHKILLDFYYPFIEKIDAGKSNIVSLKMAKPLGRNCPQCGSELLLRSGRFGEFIACSGFPKCKYTEQTEENQKENPATPDEVSEEVCDKCGSAMVVKNGRNGKFLACSGYPKCKNTKTLNQETKFSQVPCPECGGKLLWRQSRRGAFWGCEHYPKCKFISKFEPSDKKCEVPGCGGALAPRTYRNKEVYECVKCKDRTPREEAGE
(572) DNA topoisomerase 1 [Arcobacter sp. L]
1
MASMGHVRDLPKSSLGFDPSDNFKPKYMVTADKKKVISDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAILKALENPRDVDQHLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFVPEEYWKVKADFINPELKAELAKISAKTAKVDNEEQALNIESSLNQGIYKLASIEEKESIRNPAAPFTTSTLQQEASRKLGLSVKQTMVIAQQLYEGNVGNIPNHTGGLITYMRTDSLNLSTVATSAAKAVIEEEYGKEYSLSKPRVYKSTAKGAQEAHEAIRPVNLALKPSMIKEFVEPAQYKLYSLIWKRTLATQMAQAKIANTTYKIEAGRDKEFEFQSKGQRIIFAGFMKAYTEGSDNPEAALDSTEKILPNIKVGTVLELEKLESEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYVTKTEDKKLIPTQTGEIVNSFLVDHFSDIVDLGFTAKIEEEFDEIALGKIAWEQVMKDFYGNFKKTIDEKEESVHKEDYLQSREIGIDPKSGKPVSARVGRFGPFIQIGTKDDEEKPKFVAIPDNLNMDTITLDEALFLFTLPRVVGLDNSGDEIKANIGRFGPYLQVKTKFYSLKTDDPYTVDLNRALEIIKETDEAKEKSTIKTFDKEKIQILIGQYGPYIKQGRKNFKIPKSVEAKDLTLEQCLEIIAKDSKTKTSSTKKASTEKKASTEKKETKKKTTTAKKTTKKSADK
(1699) DNA topoisomerase 1 [Sulfurimonas autotrophica DSM 16294]
1
MNLIIVESPAKAKTIKNFLGKDYDVIASKGHIRDLPKSRFGITLDEETHELVPKYSVAKENAPTVKEIKEKAKKADTIYIATDEDREGEAIGWHIAHAIKKDPLELPRIVFHEITKTAIKHALESARKIDMDMVNAQQARRLLDRIVGYKLSPLLASKIQKGLSGGRVQSSTLKLVVDREREIKAFVPQEYWSIDTVFKTNIDANLIKHKDKKLSKLSIENKEQAETITQSVKNDNFTIAKIETKQRKSSTPPPFMTSTLQQTASSKLGFTPKKTMMIAQTLYEGVKTPDGTSGVITYMRTDSLNLAQEAVGAVRGIIENRYGKKYLPKEPKIYTKKAKGAQEAHEAIRPTMLQFTPEVAQSFLKADEIKLYRLIYERFMACQMEDAIFEQQSIIFKGNENEFRASGRKLIFDGFYAVTGTEDKDKLLPTLKEGEKAEIQSVKPEQHFTEPPSRYSEASLIKKLEAEGVGRPSTYAPTIATLSNRTYVTIEKKQIIPTEIAFTVTEILEKNFPNIVDINFTAEMEEELDEIAEGKVDWQKLLLEFYEKFMKQIEEGKENIVSLKLAKPLGRTCPKCGEHELLLRSGRFGNFIACSGFPKCKYTEQCDEEGNAVEKKETTADEKCDKCGADMIVKNGRNGEFLACSNYPECKNTKSINVEEKVSETPCPDCGGKISLKNSRRGPFWGCENYPDCKFISKFEPTTIKCKEEGCSGVLAPRTYRNKEVYECVKCKARTPKEEIDTKK
(375) DNA topoisomerase 1 [Arcobacter butzleri RM4018]
1
MASMGHVRDLPKSSLGFDPNDNFKPKYQISTDKKKVITDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAILKALENPRDVDQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFVPEEYWKIKADFINPELKAELAKENGKTLKISNEKQALEIEASLKQGSYKLVDIEEKESTRNPAAPFTTSTLQQEASRKLGFSVKQTMIIAQQLYEGNVGNIPNHTGGLITYMRTDSLNLSTVATTAAKAVIEEEYGKEYALNKPRVYTTKSKGAQEAHEAIRPVNLALRPSQIKEFVEPAQYRLYSLIWKRTLATQMAQAKIANTTYKIEAGKNKEFEFQVKGQRIIFAGFMKAYTEGSDNPEAALDSSEKILPNIKEGTILELEKLESEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYVSKTEDNKLIPTQTGEIVNSFLVDHFSNIVDLGFTAKIEEEFDEIAEGKIAWEEVMKNFYGGFKKTIDEKESSVSKEDYLQVNELGIDPKSGKPVSARVGRFGPFVQIGTKDDEEKPKFVAIPDNLNMDTITLEEALFLFNLPRVVGNTENGDEIKANIGRFGPYLQVKTKFYSLKTDDPYTIDLNRALEIIKDIDEAKEKSTIKTFDKEKIQILVGQYGPYIKQGRKNFKIPKGKNAEDLTLEECLEIIEKDSKGSTKRTTTKKSATEKKTTAKKTTKKSTDKK
(527) DNA topoisomerase 1 [Hippea maritima DSM 10411]
1
MNLVVVESPAKAKTISKFLGKNYSVVASYGHIRDLPKSSFGVDIEDGFKPKYVIPKDKQPIVRELKKLTKDSDLVYIATDEDREGEAIGWHITQATKLDETKLKRIAFHEITKKAILDAIKSPRSIDMDMVNSQEARRILDRIVGYKLSPLLAKKIRKGLSAGRVQSVALKLIVDREEEIQSFKPEEYWTIHLIFENSIQADLTKAYGEKFDKLFIKKEDDKARVSKLKEEIEKESFNVYSITKTKSLRKPEPPFITSTMQMAASTYLGFSAQRTMRIAQSLYEGVDIGKERIGLITYMRTDSVNIAKEALTKVRRTIKELLGDEYLPSKPVTYKTKSKLAQEAHEAIRPTDPALLPDMVKPYLTEDQFKLYDLIWRRFVASQMKPAEFRNTKITFTSYNFEAKASYKELVFDGFLRIWTFSKLNEDKIPILKKNQSVELTEVKPKQHFTEPPPRYTEASLIKELEKHGIGRPSTYATIIDTIIKRGYVVLKDKRFYPEEIGIITSRMLDKFFSDIINVKFTAQMEDGLDKIANRELTKLELLKRFYDKFKVLLENAYENMERIKPEDEPTDEVCPLCGANLVIRHGRFGKFLACSNYPKCKYTKPLQEEITEIKCDKCGAPMVVKYSRKGSKFLACSNYPKCKNTKPYPTGLKCSECGGDLIEYSSKRGRFYGCSNYPECKFTIKGELKNQKCPKCGYSLFVKKKDKWCCANKKCNYCE
(1171) DNA topoisomerase 1 [Geobacter lovleyi SZ]
1
MAHQLVIVESPAKAKTIEKFLGSEYRVLASFGHVRALPSKQGSVDTANDFEPKYHVLPESKKHIDAIKKELKGADRLLLATDPDREGEAISWHLLAALGLDKKPKIPIQRVVFHEITKDAIIHAVQHPRDIAIDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFVDQEYWTIGAKLEKQGGQTLKAGLVAVDGKKLGKFDIPDQKSADALKNAIAQGKAEVASVTRKEMKRNPAPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGVAIGEGGTVGLITYMRTDSVNLSAQALKDAHDLISVAYGKEYALAKPRFYKNKSKNAQEAHEAIRPTYLDKTPAELKKYLTPDLFKLYELIWKRTVACQMAEALLDQTSVDIAVSGQKTDSFILRATGSVIRFPGFMKLYIEGVDDEDEEKEGTLPALDEGEALKLLEVLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASTLNTLVERKYARLDKKRFFPEDVGMVVNDLLTAHFPKYVDYNFTAGLEEELDQVSRGEKQWKPLLREFWNPFISLLKQKEGEVKKDDLTTETLEEACPECGKPLAIKLGKRGKFIACTGFKEGCKYTRNLENSGTEEAAEPEVSEEKCDKCGQPMLIKSGRYGKYLACSGYPACKNIQPLNKPKGTGVTCPECKEGELTEKKSRYGKMFYSCNRYPDCKFALWDPPVTQPCPKCGFPVLVKKVYKKKGEFLKCPKEGCDYTSA
(1492) DNA topoisomerase 1 [Chromobacterium violaceum ATCC 12472]
1
MPTSLLIVESPSKAKTLKKYLGPDFEVLASYGHVRDLVPKNGAVDPEKDFAMKYQLIARNSKHVDAIVSAVREADHVYLATDPDREGEAISWHLVQILNSKKLLKDKTAQRVVFHEITKNAVLDAIQNPRDIAQDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIKAFVQQEYWSVHLDSHKSRTKFSAKLTTLGGKKLDQFDIPNEAEQASVLARLQGLPATVGSIEKKKKSRSPAAPFTTSTLQQEAVRKLGMTTDRAMRTAQQLYEGMDIGQGTVGLITYMRTDSVALANEAVEEIRGYIGLKWDADYLPKNPAVYKSKAKNAQEAHEAIRPTSILRTPEMVKPFLTTDQFKLYDMIWKRTLACQMAPAKFDTTSVDIMVGEGVFRASGQVQTFAGFLAVYEEDVDDAEDEDNAKLPLLTEGEDLPVDKLYGEQHFTQPPPRFSEASLVKALEEFGIGRPSTYASIISTLKDREYVILDKKRFLPTDTGDIVNKFLTEHFAQYVDYNFTAKLENQLDEIANGGRQWVPVMDTFWKGFKKQIDEKESISRAEVTTESLDEDCPKCGKPLSIKFGKRGRFIACTGYPECDYTRNMGETAEQAAEEAEAPTVIEGRSCPDCGGELHIKKGRYGKFIGCANYPKCKHIEPLEKPRETGVTCPECKTGQLIERKSRYGKLFYSCNTYPKCKYATWNPPIAEPCPQCNWPILTIKTTKRRGTEKVCPQKECGYAEQIAPPEGKDAAPAEEA
(1217) DNA topoisomerase 1 [Neisseria meningitidis MC58]
1
MAKNLLIVESPSKAKTLKKYLGGDFEILASYGHVRDLVPKSGAVDPDNGFAMKYQLISRNGKHVDAIVAGAKEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPREIEMDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIRAFEAQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQFDLPNEAAQADVLKELEGKEAVVTAIEKKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDSVNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPFLSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFAGFLSVYEESSDDEEGEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEYGIGRPSTYASIISTLKDREYVTLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLEDQLDEIADGKRQWIPLMDKFWKPFIKQVEEKEGIERAKFTTQELDETCPKCGEHKLQIKFGKMGRFVACAGYPECSYTRNVNETAEEAAERIAKAEAEQAELDGRECPKCGGRLVYKYSRTGSKFIGCVNYPKCKHVEPLEKPKDTGVQCPQCKKGNLVERKSRYGKLFYSCSTYPDCNYATWNPPVAEECLNCHWPVLTIKTTKRWGVEKVCPQKECGWKEQIEPPAPKE
(1043) DNA topoisomerase 1 [Methylotenera versatilis 301]
1
MSKLLIVESPSKAKTLKKYLGSDFEVLASYGHVRDLIPKNGAVDTANDFAMKYDIIERNSKHVDAIAKAVKSADSIYLATDPDREGEAISWHIAEILKSKNLLKNKVMKRVVFHEITKSAVEHAIAEPRDISMPMVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLDALKHSHGFTAKLIQLNNQKVEQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTLQQEAVRKLGFTTSRAMRVAQQLYEGMDVGSGTVGLITYMRTDSFSIAAEAIAQIRDYVKKNFDAEYLPKAAIQYKTKSKSAQEAHEAIRPTDISRTPASVRQYLTDEQFKLYEMIWKRALACQMAPAKFDAVSVDLSVGSDANLFRASGQTLVFPGFIAVYMEGTDDEEEEGESKLPHLETGEVLTVEKIYGDQHFTEPPPRYGEASLVKILEEYGIGRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTKYVDYGFTANLEDALDSVAEGEREWLPLMAEFWQGFNQQLLSKADVERPGNELIDEACPKCGKPLQKQLSRFGTFIGCTGYNDEPKCDYKRSLNGAAQVGSDPIIIGNDDESGKEIMLMNGPYGPYLQLGLAVEGDKKKPKRVSVPKEISLADMNLETAKMVLSLPRDLGLHPVTNKKIVANIGRFGPYVNHDAKFKSIPKTDSVFTIDLDGAVALLAAAHTGPAPLATLGNHPTEDGQIEVFAGRYGPYVQHGKIRATLPKSVEPESLTLDEALELLMAKAQKEAPAKKTTTKKPTAKKAPAKKPAAAKATAKKPAATKTATKKPAAKKAAVQ
(476) DNA topoisomerase 1 [Neisseria gonorrhoeae FA 1090]
1
MAKNLLIVESPSKAKTLKKYLGGDFEILASYGHVRDLVPKSGAVDPDNGFAMKYQLISRNGKHVDAIVAAAKEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPREIEMDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIRAFEAQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQFDLPNEAAQADVLKELEGKEAVVTAIEKKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDSVNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPFLSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFAGFLSVYEESSDDEESEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEYGIGRPSTYASIISTLKDREYVTLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLEDQLDEIADGKRRWIPVMDKFWKPFIKQVEEKEGIERAKFTTQELDETCPKCGEHKLQIKFGKMGRFVACAGYPECSYTRNVNETAEEAAERIAKAEAEQVELDGRECPKCGGRLVYKYSRTGSKFIGCANYPKCKHVEPLEKPKDTGVQCPQCKKGNLVERKSRYGKLFYSCSTYPDCNYATWNPPVAEECPNCHWPVLAIKTTKRRGVEKVCPQKECGWKEQIEPPAPQE
(219) DNA topoisomerase 1 [Neisseria lactamica 020-06]
1
MAKNLLIVESPSKAKTLKKYLGGDFEILASYGHVRDLVPKSGAVDPDNGFAMKYQLISRNAKHVDAIVAGAKEAENIYLATDPDREGEAISWHLLEILKSKRGLKNIKPQRVVFHEITKNAVLDAVAHPREIEMDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICERENEIRAFEAQEYWTVHLDSHKGRSKFTAKLAQYNGAKLEQFDLPNEAAQADVLKELEGKEAVVTAIEKKKRSRNPAAPFTTSTMQQDAVRKLGFTTDRTMRTAQQLYEGIDVGQGAIGLITYMRTDSVNLADEALTEIRHYIENKIGKEYLPSAAKQYKTKSKNAQEAHEAIRPTSVYRTPESVKPFLSADQFKLYQMIWQRTVACQMTPAKFDQTTVDITVGKGVFRVTGQVQTFAGFLSVYEESSDDEESEDSKKLPEMSEGDKLPVDKLYGEQHFTTPPPRYNEATLVKALEEYGIGRPSTYASIISTLKDREYVTLEQKRFMPTDTGDIVNKFLTEHFAQYVDYHFTAKLEDQLDEIAGGKRQWVPVMDKFWKPFIKQVEEKEGIERAKFTTQELDETCPKCGGHKLQIKFGKMGRFVACAGYPECSYTRNVNETAEEAAERIAKAEAEQAELDGRECPKCGGRLVYKYSRTGSKFIGCANYPKCKHVEPLEKPKDTGVQCPQCKKGSLVERKSRYGKLFYSCSTYPDCNYATWNPPVAEECPNCHWPVLTIKTTKRWGMEKVCPQKECGWKEQIEPPAPKE
(1827) DNA topoisomerase 1 [Helicobacter felis ATCC 49179]
1
MGKNTKLIIVESPTKAKTIAHFLDNSYEVIASKGHVRDLSKYAMGIKVQDNKFIPKYAIDKDHEEIVAQILQKAKNAQEIYIATDEDREGEAIGYHIAYLIDQAGNRSKDPLIEMRALEEQSQTKNPHPIFAFPRIVFHEITKTAILHALKHPKTLDVHKINAQLARRLLDRIVGFSLSSLLASKISKGMSAGRVQSAALKLVVDREREIKVFKPIIYYEITGTIAQASVSLQSYRHEKIKKQGLRDSKEALEMVANLSAQTYQVQEISTKEKNTPSPPPFMTSTLQQSASNQLGYSPSKTMSIAQKLYEGVMTSEGVSGVITYMRTDSLNIAKEAIESARVFIEQTYGAPYVPKKPKVYTSKNKSAQEAHEAIRPTNLAFTPAIAKDYLKPEEHKVYTLIYQRFLASQMSDARLESQSVSFACESLGAVFKASGHKLLFEGFYKVLGNGDKDTLLPSFTLHQEVRLEKLEAKECSTQPPARYSEASLIKTLESLGIGRPSTYAPTIALLLSRDYVSLQQKQLTPTPNAFSVIEILEKHFSEIVNATFSAGLEDKLDAIASHELNWQDMLLKFYTPFMAQIEEGKIQIASQKVSAPTGESCPKCGAPLVQRTGRYGVFVACSAYPKCKFIKSEVVQTEDLGVCEKCGAPMVSKRGRFGTFVACSAYPTCKNIRNEESKNTPALAKCPQCGGDVRAKRGKRGMFYGCDNYPSCKFISNYKPAPKPCPECGGLCVMKIYKTKPSVQECLQCHIQVEIEGEQV
(880) DNA topoisomerase 1 [Helicobacter pylori F32]
1
MKHLIIVESPAKAKTIKNFLDKNYEVIASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKELVKQIIELSKKASTTYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPRKIDMSKVNAQQARRFLDRIVGFKLSSLIASKITKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDAYFESHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYTISGIIKKSKKSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARNKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSIVLEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQSVVVACEKGEFKASGRKLLFDGYYKILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVMEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYVKQTENANDGAKQELCEKCGGEMVQKFSKNGAFLACNNYPECKNTKSLKNTPNANEIIEGVKCPECGGDIALKKSKKGSFYGCNNYPKCRFLSNHKPINKRCEKCHYLMSERIYRKKKAHECIQCKERVFLEEDDG
(764) Topoisomerase I [Helicobacter pylori F32]
3
MKDSVIIIESPNKVAKVKEITGAKVFATIGHFMQLKSYDENNNFKPTFEYDSQKKKRIFEIIEACKNKKVYIATDPDREGYAIGYHFYEKIKKIASSIYRAEFFEITPSGINKGLQNALLFENTNKQMYQSALARRVADMLLGFTLSPYLGKALGQMKGSSAGRVQTPCLKLIVDRDREIEKFKALPENEKVSYQIQAKINDNANREVIIKHCDEKGEEIKFNDKEEALKLFESLKDNKACLLKDLKISVVETKPKKPFITSTLLERASSELGLGIAEVQSLAQSLFEAGLITYIRTDAESLSVEFLNEAESFYLPIYKEVYQKREYKAGKQSQAEAHEAIRITHPHKYEDLESIVYNAGITNQDALKLYRLIFERTIESQGKNAIYDKQDLLFKIKNEYFKCSAKSLKSTGFLAMFSKKELENDDESNDDKEDKEKEQNAQFNLKIDDMLSLNDLVLATIKRNAPSPYKEASFVKLLENKGIGRPSTYASYLSTLLKREYISISQDKKHTITPTHKGKRVIEVFENAYQFIIDLTYTKQMEEVLDEIVENKSSYLDFLQNLATKCPKIEKLERNDDEIKPSSEGQITYIENILRDLQLDLSEEFKNYKEDNRIAKAFLDRYIKEHEFFEKNNKKASSSNNNEIRPATPKQINFAEILAKKHNVKLPKDYKSNIKVCGDFINEYHKK
(1497) DNA topoisomerase 1 [Helicobacter hepaticus ATCC 51449]
1
MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDHMEIVEKIKVASKKAKVTYIATDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITHSLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQRGLSAGRVQSSALKIIVDREREIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAMLEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVETNFGSMGVITYMRTDSLNIAKEAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAIRPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDALFEIQNIIFTPHNQTHLIEFKASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSMESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGLEDKLDEIAQAKMNWESVLWEFYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRKSKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGEPMIKKFGRNGEFIACSGYPKCKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKCPQCGGISVEREYRKKQVRECLKCKHRIEI
(525) DNA topoisomerase 1 [Helicobacter canadensis MIT 98-5491]
1
MSLKDLIIVESPTKAKTIKNFVGSNYEVIASKGHIRDLPKHSFGIKIDNQEFIPEYKIDESHKNIVSELKKLAKDSKTIYIATDEDREGEAIGFHIATAIGKDPQKLPRIVFHEITKKAILDSLKNPRHIDMDKVNAQQARRLLDRIVGYRLSPLIASKIQRGLSAGRVQSSALKIIVDREKEILNFKPITYYSIDIAFKEQLESELLEFKGKKIQKLSLQDKAEALEMIQQLKQESFKVKEIENKKRKTATPPPFMTSTLQQSASSILGFSPSRTMQTAQKLYEGVMTHKGSMGVITYMRTDSLNIAKIAQDEAREFITKTYGKEYAPSKPKNYATKAKGAQEAHEAIRPTLVDFTPQIAAQYLKGDELKLYTLIYNRFLASQMSDAEFELQNIFIDSNSSLLKISGRKLIFDGFYRILGNEDKDKLLPHLKVGEVLKLEKCDLSEHQTEPPARFSEASLIKTLESLGIGRPSTYAPTISLLNSREYISIEKKQIKPQEIAFKVVELLEKHFLEIVDSKFTANLEEKLDEIAENKQDWQKLLWEFYEPFIQKVNEGKTSIQSQKIALPTGENCPLCGKELIKRSGRFGEFVGCSGYPKCKYIKKEVEENAQEESYGVCEKCGKPMVKKRSRSGEFLACSGYPECKNTKSLNNSAPSAKKAVEGVKCPKCSGEILERMSRRGKFYGCANYPKCDFISTYEPTNVHCPKCNSLMAKRTYRKKAVLECIACKERIEEIQTTIKE
(642) DNA topoisomerase [Pseudoxanthomonas spadix BD-a59]
4
MRVVLCEKPSQGKDIARVLGATQRGNGCYTGSGLGVTWGIGHLIETAPPEAYGEQYKRWALEPLPIIPQHWQVVVKAKTATQFKVVKQLLAQATDLVIATDADREGEMIARELIDYCGYRGPIQRLWLSALNDASIRKALGALKPSGETLPLYYSALARSRADWLIGMNLSRLFTVLGRQAGYSGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWTIEVLLAHAGQSFVANWTPPAGCTDDAGRCLQQPVAQQADERMRAAVSAQVVSVETERMREGPPLPFDLGTLQEVCSKQLGLDVQETLDIAQSLYETHKATTYPRSDSGYLPENMLAEVPTVLDSLVKTDPSLRPLVAKLDPHQRSRAWNDAKVTAHHGIIPTLEPANLSALNDKELAVYRLIRAHYLAQFLPHHEFDRTVAQFACAGQSLTVVGKQIVVTGWRQVLAAPAPDEPDEDAQRSQVLPALHAGLSCPIGAVDLKALKTLPPKPYTQGELVKAMKGVARLVTDPRLKQKLKDTTGIGTEATRANIINGLLGRGYLLKKGRAIRASDAAFTLIDAVPPAIADPGTTAVWEQALDMIEARQMTLDAFIAKQSAWVAQLVQQYRTATLSIQLPPAPACPQCGSPMRQRTGKSGAFWSCSRYPDCKGTMAIESATGGKRSAPRKRRTAPKAS
(1405) DNA topoisomerase 1 [Pseudoxanthomonas spadix BD-a59]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNNFAMRYDLIEKNQKHVEAIAKAAKGADDIYLATDPDREGEAISWHIAEILKERNLIGNKPMHRVVFTEITPRAIKEAMARPRAIAGDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIAAACAHPSQPFTAKLVKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVTSKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGAVGLISYMRTDSVNLSQDALNEIRDVIARDYGTASLPDQPNIYLTKSKNAQEAHEAVRPTSALRTPSQVARFLSDDERRLYELIWKRAVACQMIPATLNTVSVELAAGSAHSFRASGTTVVVPGFLAVYEEGKDTRSAEDEDEGRKLPAMKPGDSVPLDRIVAEQHFTQPPPRFTEAALVKTLEEYGIGRPSTYASIIQTLLFRKYVEMEGRSFRPSDVGRAVSKFLSGHFTRYVDYDFTAKLEDELDAVSRGEEDWIPLMARFWGPFSQLVEEKKESVDRAEASGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEDKPRFASLRPGQSMHTISLEDALELFLMPRALGQDKGEEVSVGIGRFGPFAKRGSSYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKTFPDSQIQVLNGRFGPYISDGKLNGKIPKDRDPASLTGEEVIRLLEETGKPVRKGFGAKTPQKGAKTTARKVTKKAEPAEKKPTASKAVKKATGKTARNPGKGTGAASKLAAKKTVAKKSVAKKAASQGAAPF
(977) DNA topoisomerase 1 [Methylococcus capsulatus str. Bath]
1
MAQHLVIVESPAKARTIEKYLGKSFQVYASYGHVRDLIPKEGAVDPDHDFSMKYAIIEKNKKHVQAISKAMEKADALYLATDPDREGEAISWHLYELLKEQQVLDSKPVHRVVFHEITKRAITEAVENPKTLSTDLIHAQQARRALDYLVGFKLSPLLWKKIRRGLSAGRVQSPALRMIVERELEIERFEVQEYWTIEAAIQTEDQALSARLTHLAGEKLEQFSIVNEAQAQATRQSLLDQARGKLQVVRVEERERKRNPAAPFTTSTLQQEAARKLGFTTRRTMTVAQQLYEGIDLGGEAVGLITYMRTDSVNLAQEAVQELRALIESRYGKDNLPAQPRLYKTKSKNAQEAHEAIRPTSAFRTPESVKAHLTPDQFKLYSLIWKRSVACQMVHATLNTVTVDFACGSADNLFRATGSTVIHPGFMSVYREGRDDMPEESDEIYLPKLVEGQEVDLKDVTPSQHFTEPPPRYTEASLVKALEEYGIGRPSTYATIISTLQQRHYVELENKRFRPTDLGRVVNKFLTEHFNRYVDYNFTANLEDDLDAVSRGEKDWIPLMREFWGPFHALIGEKDESLKRADVTHEAIDEKCPECGSPLSIRLGRNGRFVGCTNYPQCKYTRNLAGKESEQTEPEVVEGRQCPKCHSPLVIKTGRYGRFIGCSGYPACRHIEPLEKPTDTGVPCPECGQGTLTKRKSRFGKLFYSCSTYPKCSYAVWNPPIAEACPACQWPVLTLKTTKRRGTEKVCPRKECGYAAPYEGEPLTDFAA
(1370) DNA topoisomerase [Xanthomonas axonopodis pv. citri str. 306]
4
MRVVLCEKPSQGKDIARVLGAHRREAGCLGGPGITVTWGSGHLIEAAPPEAYGEHFQRWTLPIVPPRWQWVVKARSAAQFKVVKRLLGEASELIIATDADREGEMIAREMIDYCGYRGPVQRLWLSALNDASIRKAFGALRASSETLSLYHCALARSRADWLVGINLTRLFTLLGRHAGHDGVLSVGRVQTPTLKLVVDRDREIAAFVPVPFWSIDVSLSAANVPFSAHWLAPRTATDDAGRCLRQSVARHAADAIRAAGTAQVVHTETERVREGPPLPFDLSTLQEVCSRRLGLEVQETLDIAQALYETHKATTYPRTDAGYLPENMLAEVPTVIQSLVKTDPALQPLIDRLDFRQRSRAWNDAKITAHHAIIPTLEPADISAMSAKELAVYRLIRAHYLAQFLPHHEFDRTVVRFRCGGETLQAVGKRIAVPGWQHAFSAPSLPHVAADGADTEGSDEAPREQMLPVLQEGISCQVSALDLKSLSTKPPRPYTQGELVKAMKTVARLVTDPRLKQKLKDTTGIGTEATRANIISGLLSRGFLIRKGRAVRASDTAMMLIDAVPAAIADPGTTAIWEQALDMIEARQMGLESFVEKQAAWVTQLVRQHLGTTLAIRSPEGPPCPLCGAATRQRTGRSGPFWSCSRYPDCKGTAPVAPAQAGPDGQKRSRSRGARAQR
(1404) DNA topoisomerase 1 [Xanthomonas axonopodis pv. citri str. 306]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNGFAMRYDLIEKNEKHVEAIARAAKGADDIFLATDPDREGEAISWHIAEILKERGLLKDKPMQRVVFTEITPRAIKEAMAKPRMIAGDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIPREYWSIDAHCRHPSQAFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALAEIRDVIARDFGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSEDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVPGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNVPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTANLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGTDPVSGKEVSARIGRFGPMVQIGTVEDEDKPTFASLRPGQSIYSISLEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSTYASLKKEDDPYTIDLARAIFLIEEKEEIARNRVIKEFDGSDIQVLNGRFGPYISDGKLNGKIPKDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNTVKDSAPKKPAVKKTATKTAASKTAVKKAPAKKTATKKAAKRVVKKTVSKAAG
(424) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1382) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(110) DNA topoisomerase 3 [Serratia proteamaculans 568]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGNNDVVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNAIKKLLHEADEVVHAGDPDREGQLLVDEVLDYLALSPEKRHSVRRCLINDLNPQAVERAIERLRDNRDFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVSKDFFEVKAHIVTPKDERFVALWQPSDSCEPYQDEEGRLLHRSLAEHVLKRIEGQPALVTSYNDKRESDTAPLPFSLSTLQIEASKRFNLSAQQVLDVCQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISVHQPDLYPQPVIDSDRRNRCWDDKKVDAHHAIIPTARASKVSLSQDELNVYGLVARQYLMQFCPDAMFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKDDQLLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIELLFKRAFLYKKGRYIHSSETGRALIHSLPDIAARPDMTANWEATLTQISEKSCRYQDFMQPLVGTLQELIYQAKQSRASMAFRGLPPSPSGGAKKRKKSAGKAREKSE
(93) DNA topoisomerase 1 [Serratia proteamaculans 568]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTEDKAKKKVKKDPTTALVNRMGVDPYHGWKAHYEILPGKEKVVAELKSLAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQNAFKQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKGDTALQMEVTHAHDKPFKPVNREQTHAALNVLEKARYTVLDREDKPTSSKPGAPYITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALEMVRGYIGDNFGDKYLPKAPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLSVKAADYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPYVEVGSDLELQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEENFRELMNYDFTARMENGLDQVANNQAEWKAVLDEFFAEFSEQLETAEKEPEEGGMRPNQMVMTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPETEVLNILEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEEGEFRLKGYDGPVVECDKCGSEMHLKMGRFGKYMGCTNESCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADAEGNKTLVRFSRKTKQQYVSAEKDGKATGWSAFYIDGKWVEGKK
(1256) DNA topoisomerase [Serratia proteamaculans 568]
4
MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPWRESVLPIVPTQWKMTVKKETADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHFTGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAREQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRATLQKGGIAFPASWVPAANYCDEEKRCIQQNVAQAVVQLCQQTGHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMSANQALSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTQSGSVARLDRTFVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEATFNIGGQLFRTRGKVEVVAGWKVLFQHDVSEAKEESTDTDDVRLPALVKGETVAVAGAELKTLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYLEKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGHLVEKGKAQAVKFTAPPSPPCPTCSGTMRRRAGKKGSGAFWGCSNYPTCQGIINIDAKGGRKAKRYKAKSPAKNKTTKSE
(1882) DNA topoisomerase [Serratia proteamaculans 568]
4
MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPWRESVLPIVPTQWKMAVKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHFTGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAREQGYGEVLSIGRVQTPTLALVVNRDRDITNFISKPYWQVRATLQKGGITFPANWVPAANYCDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMSANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRAFVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQYLSLHEVDVTEATFNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELKTLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILDTLFKRGYLEKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGHLVEKGKTQAVKFTAPPSPPCPTCSGSMRRRAGKKGGGAFWGCSNYPTCQGVINIDAKGGRKAKRYKAKSPTKNKATGSE
(202) DNA topoisomerase 3 [Actinobacillus pleuropneumoniae serovar 5b str. L20]
10
MISEKRILRVFLAEKPSLARAIADVLPKPHTRGDGYIQCGENDTVTWCIGHLLEQAEPDIYDERFKMWRMEHLPIVPQQWKLVPKKETLKQLKAVEKLVKKADVLVNAGDPDREGQLLVDEVFSYLNVPPEKRNRIQRCLVSDLNPSAVKKAIDKLQNNRDFIPLATSALARARADWLYGINMTRAYTLQGRWAGYQGVLSVGRVQTPVLGLIVRRDLEIENFVPKDYFEVLAHIVVPETQERFTAQWQPSKACEDYQDEDGRVLSKSLAENVVKRITDQAALVTDYQDKIETETAPLPYSLSVLQIDAARRYGLSAQAVLDICQKLYETHKLITYPRSDNRYLPNEHYADRFKVMAAIAHHLDEYKEKPEAVNPEIRNRCWNDKKVEAHHAIIPTVRQGSVKLTENEKRIYQLIARQYLMQFCPDAEYRKGKIVLEIAGGTFNAQARNLIVAGWKALLGKEDSDEVLEPLLPVVKKGQQLHCEKGEIVSKKTQPPRHFTDASLLSAMTGIARFVQDKQLKKVLRETDGLGTEATRAGIIELLFKRGFLIKKGRNIHSTEAGRILISALPDEATQPDMTAHWEMQLTDISKKQASYQQFMQVLTSKLPELLHTERQKLQNLSRIQPPASYRKRSNFKKNLQTAEK
(1406) DNA topoisomerase 1 [Actinobacillus pleuropneumoniae serovar 5b str. L20]
9
MGKSLVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPKSGSESEKGEKAKPISTKGMTAEQKAKLKAEKDRAALVKRMGIDPYHDWKANYQILPDKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDERFSRVVFNEITRNAIQKAFEQPDHLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWEILANTLTAKGKLPLDLTGYKGKKFSAKNQKQADEAVKSLQGSEFIVSEIDKKPTSSKASPPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALAMARGYIENQFGAEYLPAKPNFYSSKEGAQEAHEAIRPSDVNVKMADLKGMEKDAERLYDLIWRRFLACQMTPARYDSTSLTVTAGDYELKAKGRVLRFDGWTKALPVQGKTAEDQVLPEVALNEKLALEEVLPSQHFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLDESFSDLMNYDFTANMEETLDQIAEGNKNWKEALNNFFKDFSEQLTKAELDELEGGMKPNSLVPTEIDCPTCARKMAIRTASTGVFLGCTGYALPPKERCKTTMNLIPESELLNVLDEESEAKALLARKRCPKCDSAMDSYVIDPQRKLHICGNNPNCDGYVLEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMGCTACDNTRKILKNGEVAPPREEPTHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELAQYRDRLPEKLQYLADAPQQDPEGNEAIIRFSRKEKRQYVTSEKDGKATKWIVDYLDGKWLERKK
(1391) DNA topoisomerase 1 [Haemophilus parasuis SH0165]
9
MGKSLVIVESPAKAKTINKYLGSDFVVKSSVGHIRDLPTSGAEKEEKTEKAKAVSTKGMTAEQKALVKSEKERTALVKRMGVDPYHDWNATYQILPGKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGENERFSRVVFNEITKNAIKQAFEKPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEFWDILAKTSAKKGDLALELVQHKGKKFSVKNQKEAEQAVKSLQNSAFIVTEIDKKPTSSRAKAPFITSTLQQTASTRLGFSVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALTMARSYIEKQFGDRYLPEKPNFYASKEKAQEAHEAIRPSDVMVKMQDLSGMEKDAERLYDLIWRQFLACQMTPAEYDSTSLTVTAGDYELKTKGRVLRFDGWTKVLPIQGKTAEDQELPEVSLNETLKLNAVEPSQHFTKPPARYSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNEAFSDLMNYDFTANMEDTLDQIASGNSNWKVELNRFFADFSEKLTTAELDELEGGMRSNNLVATDIHCPTCQRQMAIRTASTGVFLGCTGYALSPKERCKTTINLIPEAELLNVLDEDSETNALMKRKRCPKCDTAMDSYVIDPQRKIHICGNNPNCDGYVIEEGSFKIKGYDGPIVECDKCGSDMHLKLGRFGKYMGCTNCDNTRKILKNGEVAPPREEPVAFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELALYRDRLPEKLQYLADAPQQDPEGNEAIIRFSRKEKRQYVTSEKNGKATKWIVDYLDGKWVERHR
(1495) DNA topoisomerase 3 [Haemophilus parasuis SH0165]
10
MRLFIAEKPSLGRAIADVLPKPHTRGDGFIQCGEDNVVTWCIGHLLEQAEPDAYDERFKMWRMEHLPIIPEQWKLIPKKETLKQFKVVERLIKQADILVNAGDPDREGQLLVDEVFGYLNLSPERKSQIQRCLISDLNPNAVKKAIEKLQFNRDFVPLATSALARARADWLYGINMTRAYTLQGRWAGYKGVLSVGRVQTPVLGLIVRRDLEIENFIPKDYFEVLANVVVPETQERFQAQWQPSKACEDYQDEDGRVLSRPLAENVVKRITDQAACVTEYQDKMESEAAPLPYSLSALQIDAARRFGLSAQDVLDVCQRLYETHKLITYPRSDNRYLPNEHFADRLKVMAAIAHHLPEYAQKPDAVDPNKKNRCWNDSKVEAHHAIIPTARQGRQVHLTQNEQWIYQLIARQYLMQFCPDAEYRKGKIVLNIAGGTFIAQARNLVVAGWKSLLGKEDNDEIVEPLLPVVKKDQQLWCESGEIISKKTQPPRHFTDATLLSAMTGIARFVQDKQLKKVLRETDGLGTEATRAGIIELLFKRGFLIKKGRNIHSTEAGRTLISALPDVATQPDMTAHWEMQLTDISKKQASYQQFMADLNQRLPSLLSSPNKQILQSLAKITPLTTSSKSRYTRKSTQNVEK
(1354) DNA topoisomerase 3 [Shewanella denitrificans OS217]
10
MRLYIAEKPSLGRAIADVLPKPHKKGDGFITAANGDCVSWCIGHLLEQAEPDAYDVAFKSWKLEHLPIIPTQWQLKPKSSTRSQLSVLKKLVKQATHLVNAGDPDREGQLLVDEVIAYLGVKGDKLNQVQRLLISDLNPQAVQRALNQLKSNRDFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDEEIEAFVPKPFYEVLAHLLTDKQQGFTAKWQPSAACEPYQDEEGRVLVKGLGQNVVERISGQPAQVTGLVAQDKRQAAPLPYSLSSLQIDAAKRFGLSAKEVLDTCQSLYERHKLITYPRSDSRHLPVEQFSLAPSVINAVIKGAPTLISHTDAPNPKLKSKAWDDSKVEAHHAIIPTEKIAHLSALSMNEARLYQHIARQYLAQFYPAYQYAETQVEVTIAGGIFTTKARQNKSLGWKSLFSNNNKIVEHNTENNQEGEPESQTLPALKKGQWLNCERGELLEKMTQAPKHFSDASLLSAMTGIGRFVTNVEIKKILKDTDGIGTEATRAGIIELLFKRGYLLRQGKSILATPVGRGLINSLPMSATTPDMTALWEASLDKISHKTMRYQAFMAPLIQQLSELIGQAASELPRALQGLASPSKGKGFPKKKSAYSTKSSGKYKAKNAKAGTVAKKKS
(58) DNA topoisomerase 1 [Shewanella denitrificans OS217]
9
METIFYLFETFGANKTMGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSDGSASTKTAAEVRKMSPEEKAKYKLIRDKQALVSRMGINPEKGWAAKYQILPGKEKVVKELKALAESADQIYLATDLDREGEAIAWHLQEIIGGDASRYQRVVFNEITKSAIQDAFSQPSSLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDINAELNTAASQVLKMQVAKYQGESFNPINKAQAEQAVERLTNASYSVSAREDKATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVENVREMIAADFGTKYLPADPIRYGSKEGAQEAHEAIRPSNVQVQSASLTDMERDAQRLYELIWRQFVACQMTPAQYDATRLTVKAGDYELKASGRTLRFDGWTRAQPPMGKKNEEDNTLPHVDKGESLTLNTLAPKQHFTKPPARYGEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFFAEKMGEIVSDRLVGSFKELMSYDFTASMEQTLDDVAQGKLEWKQVLDGFYGDFTKQLEKAELDPEDGGMHLNQMVLTEAISCPTCDRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSDAEDAETDALRAKHRCGKCGTAMDSYLIDEKRKLHVCGNNPSCDGYEVEAGQFKIKGYEGPLIECDRCGNDMELKNGRFGKYFGCTNSECKNTRKLLRSGEAAPPKEDPIFLPELKCTKSDAHFVLRDGAAGIFMAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPVEDDDGNKAAVKFSRKTKEQYVATEVDGKATGWTAKYHGGKWLVEQTKKKAKS
(1805) DNA topoisomerase 1 [Shewanella violacea DSS12]
9
MGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHVRDLPTSSSPDSKVATKTPAEVRKMAPEEKAIYKSKKAKQALVARMGVDPDNGWKAKYQILPGKEKVVKELQALAEKADKIYLATDLDREGEAIAWHLQEIIGGDESRYQRVVFNEITKTAIQEAFSKPAHLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEREGEIKAFVPEEFWDIHAQLNTQANDLLKMQVVKFQGKAFNPVNEQQTLEAVSALSQSSFVVAARDDRATQSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVREMIAKEFGDKYLPDEPIRYGSKDGAQEAHEAIRPSDVKVHAALMSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKSGEYELKATGRTLRFDGWTRVQTAIKKKNEEESTLPHIEQGDKLDLKELDPKQHFTKPPARYGEASLVKELEKRGIGRPSTYATIISTIQDRGYVRVENRRFYAEKMGEIVSESLVGSFKELMSYDFTAGMEQTLDDVAKGELKWKKVLDGFYKDLTKQIEQAELPPEEGGMRPNEMVPTDNIKCPTCERPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSENSEDVETDALRAKHRCDICGTAMDSYLIDETRKLHVCGNNPICVGHEVELGQFKIKGYEGPIIECDRCSNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPDVKCTKSDGYFVLRDGAAGIFMAASTFPKSRETRAPLVEELVKYRELLWPKYAYLADAPVKDDDGNKASVRFSRKTKEQYVATDVDGKATGWTSKFIDGKWVTEAKKKAKPKAKAATTTKAKAKPKAKAKPKKAEKTED
(604) DNA topoisomerase 3 [Shewanella violacea DSS12]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGHIMAANGDCVSWCIGHLLEQAEPDSYDAAYKSWKFEHLPIIPEKWKMKAKPKTRSQLTVLRGLVKKATQLVNAGDPDREGQLLVDEVISHLGVKGEKLNNTQRLLISDLNPQAVKRALGQMRSNREFIPLSTSALARSRADWLYGLNMTRAYTLQGRKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFVSKSFYEVQANLNTEKNEAFRAKWQPSEACQPYMDEEGRVLSKGLAQNVVDRISDKPAQVTQVIAKDKQQNAPLPYSLSSLQIDAAKRYGMSAKEVLDTCQTLYERHKLITYPRSDSRYLPAEQFSQAPQVIGAVLSGAGELVENSDKPDPKIKSKAWNDSKVDAHHAIIPTEKRVNLSSLSAWERQIYLQVARQYLAQFYPPYLYSETEVHVLIEGGHFKTKAKQERAQGWKQLFTRNNTANTNSASTGKEDDDESQQKLPALKKGQSLHSGAGELIEKQTQPAKHFTDATLLGAMTGINRYVTDPEIRKILKDTDGLGTEATRAGIIELLFKRTFLSRQGKTIIATEVGRGLINSLPLSATTPDMTALWESNLDAISRKEAKYQSFMTPLIDSLSHLITQAGSQLPTALQGVKAPKSSFKKRRFTKKKSKS
(42) DNA topoisomerase 3 [Pseudoalteromonas sp. SM9913]
10
MKLYIAEKPSLGRAIADALPKPHKKHDGYIEVANGDCVSWCIGHLLEQAEPDDYDERFKKWQFEHLPIVPEHWQLKAKTKTRKQLTILKKLIKQATTLVHAGDPDREGQLLVDEVIEQTKISQTKKQSIQRLLISDLNLTAVKKSLNAMRANRDFIPLSVSALARSRADWLFGMNLTRAYTLAGQKAGFGNVLSVGRVQTPILGLVVNRDNEIANFVSKPFYEVLAHLVTPEQQSFTAKWIPSKACEPYQDEEGRVLNKALAENVTSRIANQPANVTALEQKQKKQTAPLPYNLSALQIDAAKAFGMPAQKVLDICQVLYERHKLITYPRSDNRYLPREHHQDAPAILKAIAVNGGQSVELVNEANAKQRSKCFNDAKVAAHHAIVPTAKQLKSVSLANDEAKIYQLISRHYLIQFYPDYIYNESKVEVTIAGGLFKASAKQDVSLGFKLLMGKSELKEEATLPYLEKGMALTCTKGEVVQKHTSPPAHFTDATLLAAMTGISRYVKDLQIKKILKETDGLGTEATRAGIIELLFKRRFLKREGKAIKATETGLALISVLPEGLSSPDLTAKWESSLGDIAQQAMSYQQFIQPLLADLTNFVSQAANCNSQAFALLPKTSPKKRFAKRTKKAPYKKSSYKKSPAVN
(1343) DNA topoisomerase 1 [Pseudoalteromonas sp. SM9913]
9
MGKSLVIVESPAKAKTINKYLGNDFIVKSSIGHVRDLPTSGSGKNKVPASKTPAEVRKMPPDEKAAYKQQRDYSNLVARMGIDPEKGWEPHYEVLPGKEKVVQELQKLAQNADQIYLATDLDREGEAIAWHLQEIIGGEPEKYKRVVFNEITKNAIQQAFETPGELNTDMVFAQQTRRFLDRVVGFMVSPLLWAKVARGLSAGRVQSVAVRLLVEREREIKAFIPEEFWDIHADVKNSESDLRLEVTKQADKPFKPVNEAQATAAVKSLENAEYKVVSVEEKPSKSRPSAPFITSTMQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKDAVEMCREYVTNEFGAKYLPADPINYSSKGNAQEAHEAIRPSSVSVLSGHVEGVDADAKKLYELIWRQFVACQMVPAEYDLTTLTVAANDFTLKAKGRVLRFDGWTKVQPAVRKKNEEDQSLPAVKQGEVLTLVELDPKQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFFAEKMGEIVTDRLVENFTDLMNFDFTAKMEGRLDDIAEGERVWTQVLDKFYADFSTQLNIAKGEPDEGGMRLNQMVETDIDCPTCGRKMGIRTASTGVFLGCTGYNLPPKERCTTTMNLVSGDEAVAADVEDVETETLMQMKRCPICETAMDSYLIDETRKLHVCGNNPACQGHVVEEGTFKIKGYDGPIIECDKCGADMELKSGRFGKYFGCNNDECKNTRKLLKNGEAAPPKEDPVHIPELECEKSEAYFVLRDGAAGIFLAANTFPKSRETRAPKVEELQRFRDRISPKFYYLADAPAKDPDGNLAVVRYSRKNKVQYVMTEVDGKATGWTAHYEGGKWVEEAKKKAAPKKKAAAKKAPAKSKAKAKPKKDDE
(108) DNA topoisomerase 1 [Pseudomonas entomophila L48]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKTAGEAPALSPKEKARRQLVARMGVDPEAGWKAKYEILPGKEKVIDELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSQPGDLDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFNPEEYWEVHADLGTAKNAKVRFEVAREKGEAFKPLNEAQAMAALEKLKASSYSVVKREDRPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSTDAVEMARSYIENEFGKQYLPDAPVVYGSKEGAQEAHEAIRPSDVNTHPTKLSGMERDAERLYELIWRQFLACQMPPAQYLSTSVTVAAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMAQGEALKLIQLDPSQHFTKPPARFTEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVTLHNRRFYSEKMGDIVTERLSESFANLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFSKKLLTAESAENGMRANQPTLTNIACKECGRPMMIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESLVLRGKHRCPICATAMDAYLLDEKRKLHICGNNPDCAGYEIEEGSYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNATCKNTRKLLKSGEAAPPKMDKVDMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVLEIVPHKHEIDPKYHFLCDAPQKDPDGRPAVIRYSRKTKEQYVQSEVDGKPTGWKAFFDGKAWKVEDKR
(1302) DNA topoisomerase [Pseudomonas entomophila L48]
4
MRLFLCEKPSQAKDIAKVLGAQRRGDGCWQGTDVCVTWCIGHLLETAPPDSYDERYKRWSLDDLPIIPEKWKMTVKPKTASQYKAVKRLLGEARELVIATDADREGEMIARELVEHCRYRGPIQRLWLSALDDASIRKALARLLPGQETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIDVQLESAGNVFNAQWRAPEDACDDQGRCLKQALAQQAAHDMQAAGSARVMKIATERVRETAPLPFDLGTLQEVCSKKLGLGAQETLDIAQALYETHKLITYPRSDSGYLPLSQHGEAPGILAALQRADASLAPLQPYLDPQRRSRAWNDQKVSAHHGIIPTAAASDPSRLPPKYKAVYTLIRARYLAQFLPNHEYDRTQADFDCAGHTLRAVGKQIIEPGWRRALPEALMPQKGREAPPAQVLPALREGQDCAVQGLQLKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKETTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQNGEMSLDEFVARQSAWMGKLVQRCSGMRLTITGPAAGKAAAPWKKKRKSSGKGKVAGSGGKAAAGKPRQPRRKTAT
(371) DNA topoisomerase [Marinomonas sp. MWYL1]
10
MILYIAEKPSLARAIAAALPTPQKKEEGCIWLPNGDCVSWCIGHLLEQAEPHQYNPAYKSWNLDHLPIIPTDWQWQEKANTKKQLGILKKLIKKATVLVHAGDPDREGQLLVDEVLHYTKVPAQKLKNTQRLLVNDLTPSAVKKALSNLRLNNEFAALSRSALGRARADWLFGLNLTRAYTIKGRQAGYQGVLSIGRVQTPVLGLVAARDKEREAFVPKDFYQVWASIQTSQGAIFQAKWLPSEACKPYMDEENRVLSLPLAQNVANRITNKPAVVVEANYKQKKQPAPLPYSLSALQIDAAKAFSLSAQQVLDTCQALYERHQIITYPRSDCRYLPTQQHKDASAIIAALARSGTDIQQGAENADASRKSKAWNDKQVTAHHAIIPTTQAHKAASLSKTEALVFNLIARQYLMQFYPEYDYLASYIKLEIEGGLFEAKGNTPLALGWKALLPNKNKSKDPEDENQNELPKLSKNEELCCIQGQVQEKVTTPPAAFTDATLLAAMTGISRFVTDKDIRAILKETDGLGTEATRANIIELLFKRGFLIRQGKQIHASQTGRAFIDCLPMQLVTPDMTAKWESALNSISLGETSYQEFMTNLEGNLNQLLSASRDMPTSALQNLPQPSKSPFAKRKGSTSKRTASTRKATGTKSNSTKTTSSNTRRRSKAPS
(583) DNA topoisomerase 1 [Marinomonas sp. MWYL1]
9
MGKSLVIVESPAKAKTINKYLGNDFIVKSSVGHIRDLPSGTTATSTPQERAKQAALTRKMSPEEKLEYKSSKARKQLISRMGVDPESNWKAHYEILPGKEKVVDELKRLAKNADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIKAAFETPSELDMDRVNAQQARRFLDRVVGFMVSPLLWSKVARGLSAGRVQSVAVRLIVEREKEIRAFVPDEFWELDAMLATPSKEVIKFEAAKYQDKEYRPVNKAQSDEHVARLNDAKYLVSSREDKPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSVDAVEALRGYILSKFGEAYLPAEPIRYSSKEGAQEAHEAIRPSDVNVRVDDLQGMEKDAHRLYDLIRSQFMACQMTPAEYTSTTITVTSGDYEFKAKGRILRFDGYTRAMQAVAKKGEDNILPDVGQGEYLTLKELLPEQHFTKPVARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGDIVTERLVDSFSSLMNFSFTAQMEEQLDDIAEGHKDWIKTLNAFYKDFSSVLAKAESPDGGMMPNEPTPTDVECPTCSRPMQIRTASTGVFMSCSGYALPPKERCKATINLTRGDEAIPVDDEEGESKALINKHRCKICGSAMDSYLMDEHRKLHVCGNNPACSGYEVETGAFKIKGYDGPTLECDKCGSEMQLKTGRFGKYFGCTNEGCKNTRKLLKNGEAAPPKMDPVPMPDLACQKVDDHYVLRDGATGLFLAASQFPRKRETRAPLVEELLPYMDQIDPKYHFFAKAPKKDSEGRPAIIRYSRKTKEQYVMTEEEGKPTGWKAFYVGSKWVIEEGKKK
(1215) DNA topoisomerase 1 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
1
MSKHLVIVESPAKAKTIQKYLGNDYDVLASYGHVRDLPARKGSVNPEKHFSMTYVPIEKNARHIDTIAKTLKKSDSLLLATDPDREGEAISWHIFELMKERNLLKDKSVHRIFFNEITKAAIQDAINHPRSISMDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVEREEEIERFIAQEYWKIIAKCAHASTEFEARLTHYNEEKLQQFSVTQQEQAHEIKKQLIAQAQGFLTVAQIDKKQRKRKPSPPFITSTLQQEAARKLGFTARKTMMVAQQLYEGIDIGTGTVGLITYMRTDSVNLAKEAIDEIRDYITQRYKGDNCPNSPRIYKTKSKNAQEAHEAIRPTSIKRTPEMVQGSLTSDQLKLYSLIWKRTVASQMADAILDTVSVDFSCGKGNTFRANGSTIAFPGFLSVYEEGRDDSKDEDNEDKILPAFNVGEKIKVSDIETNQHFTEPPPRYSEATLVKALEEYDIGRPSTYASIIHTLQQREYVVVEKKRFLPTDVGRIVNRFLTNYFTRYVDYQFTAGLEDTLDAIARGEKDWIPVLEEFWQPFVQQIQNIDEQVQRKDVTTELLDEKCPKCQKPLSIRLGKRGRFIGCTGYPDCDYTQDISNPEGEKSEPEVVEGRSCPLCHGALHIKTGRYGKFIGCSNYPECKHMEPLEKPSDTGVTCPKCSQAKILQRKSRKGKIFYSCGNYPKCDYALWNEPLDLPCPKCAWPILTLKESKKFGRQILCPREGCDYSAKED
(458) DNA topoisomerase 1 [Halorhodospira halophila SL1]
1
MGKSLVIVESPAKARTINKYLGSDYEVMASYGHVRDLVPKEGAVDPSSGFAMKYAPIDKNQKHVDAIAKAARKADALYLATDPDREGEAISWHLVELLRDKGTLDDKPVYRVVFHEITKGAIQEAMNNPRDISEELVNAQQARRALDYLVGFNLSPLLWRKITSGLSAGRVQSPALRMICERETEIEQFEPQEYWSVEADAAKAQQPFMAKLSQLHGEKVRQFTITDETHAQEVDRTLREAARAQPDPARIGPTGDGETEVIGTLRVASVERKQRRRNPAAPFITSTLQQEASRKLGFTASRTMRIAQQLYEGIDVGEGSAVGLITYMRTDSVNLSGEAITEMRQAITDRYGADKLPGQAQVYKTRSKNAQEAHEAIRPTSASRHPDDVRAYLNEEQRKLYDLIWKRAVASQMKHATIHTVAVDLAADADARHLLRATGSTVADPGFMVVYREGNDEGKDDSGEKFLPELEEGEQVDLHAIRAEQHFTEPPPRYTEASLVRALEEYGIGRPSTYASIISTLQNRNYVEMDGKRFIPTDIGRTVNKFLTEHFDRYVDYDFTARLEDDLDAISRGEQDWVPVLEAFWEPFRERVEEKKNVSRQEAVQARELGTDPKTGKPVTVRIGRYGPFAQLGSRDDDEKPRFAGLRPGQSIDTITLDEALQLFKLPRDMGETDEGEDVQVSIGRFGPYVRYGKKFVSIPKDEDPYTITKERAHELVREKKQADANRIIHDFGDGIQILRGRYGPYITNGEKNAKVPKDREPDSLTHEECQDLIAKAPARKGRRGGAAKGGRGRSKATS
(373) DNA topoisomerase 1 [Allochromatium vinosum DSM 180]
1
MNLVIVESPAKAKTIKKYLGPSFEVVASYGHVRDLVPKEGAVDPDHGFAMKYQIIERNEKHVQSIAKKLKDCEALYLATDPDREGEAISWHLHELLKSRRQLGDKPVHRVVFNEITKRAVQDAIANPRQISYDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREAEIEAFVQREYWTIEADTAKDARPFVARLTTFAGEKVEQFTITDEARATEVKTALEQAAGGKLKVEQVERKQRKRQPAPPFITSTLQQEAARKLGFTAQRTMRVAQQLYEGVDVGSGAVGLITYMRTDSVNLAQEAIDEIRAYVVERYSEADLPDAPRLFKTKAKNAQEAHEAIRPTSIRREPAAVKAHLTVEQFRLYELIWKRTLACQMAHALINQVAVDLSAGAGNMLRATGSMVVDPGFMRVYLEGRDDAKGADDDEDRMLPEMKVGELVDLLAIRPEQHFTEPPPRYSEATLVKALEEFGIGRPSTYASIISTLQDREYVILDKKRFVPTDVGRVVNRFLTDYFTSYVDYDFTARLEDDLDAVSRGEGDWVPLLERFWRPFKDLVDHTQEHVKRSDVTQERIEETCPKCGGQLAIRLGRNGRFIGCTQYPECDYTRDLDPDKAEREAPEVVEGRSCPLCGSALEIKRGRYGKFIGCSAYPNCKHIEPLDKPEDTGVTCPKCNKGTLQKKKSRRGKEFYSCSTYPKCDYALWDEPLAEPCPSCGWPVLTLKITKTQGAAKICPQKECGYRAPVEDQEAER
(1598) DNA topoisomerase 3 [Vibrio splendidus LGP32]
10
MSRLIIAEKPSLGRAIAAALPNPQKKDQGFIKCGNGDVVTWCIGHLLEQVEPDAYDDRYKKWNLADLPIVPEQWQLRPRKTSSKQLTLIRKLLKDATQIVHAGDPDREGQLLVDEVIDYCKVSKAKKESMDRLLISDLNLPAVKRALSQMRSNRDFIPLSISALARSRADWLYGMNMTRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFIPKDYFTLHALIPYQNNGQSFDIRARWKPSEACKPWQDEEGRVLNRKLVENVANRIANQPATVTESEQKQSKQAAPLPYSLSALQIDASKRFGMSAQQVLDTCQSLYEKHKLITYPRSDSRYLPKDHYSQRESVVDAIANNAKELQSGAQGADLSLKSKAWNDSKVDAHHAIIPTPKKSAVNGLSANEMKIYQQIARQYLMQFYPPAVFADAKLVFDIAGGVFIAKGRQLINPGWKVLMGKTDTEEKGDGTDTVPPLDKGTVLTCREGIIGDKKTEPPKHFTEATLLQAMTGIARFVANKDLKAILKETDGLGTEATRAGILDTLFKRQLLTRQGKSIHSSPAGRGLINALPEDSTFPDMTAHWEHQLQGMAERNQAYQPFMQELESKIDGLMGKVKTGEVPESLRHLPKVERPAFKRRKGGGAKSYANKGTYAKKGTYAKKGTKS
(789) DNA topoisomerase 1 [Vibrio splendidus LGP32]
9
MGKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTAGQSTGQKAAAVSTKGMSPEDKARIKKEKDRKALIKKMGINPYQEWEANYQILPGKEKVVAELQKLAENADHVYLATDLDREGEAIAWHLREIIGGDETRYKRVVFNEITKNAIQQAFETPGELNIDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFIPEEFWDVHADTKTAEKTDFRLQVAQKDGVAFKPDNEAQTQAAVSVLEKAQYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVEAAREYIGSEFGAQYLPPKALVYGSKEGAQEAHEAIRPSSVDVKSEDLNGVDADAHKLYSLIWNQFVACQMTPAQYDSTTVSVKADEYTLKAKGRILKFDGWTRVQRPMGKNEDTILPAVQVGEKLDLIALDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVEQRRFYAEKMGEIVTDRLDGSFNDLMNYDFTARMEQKLDQIAEGEASWKGVLDNFFEDFTGDLEKADLDEDAGGMKPNHIVETDIECPTCSRKMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEDGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYVVEHGEFKVKGYDGPLVECDKCSSDMVLKNGRFGKYMDCTSEDCKNTRKILKNGEVAPPKEDPVHFPELPCENSDAYFVLRDGASGLFMAASNFPKSRETRAPLVEELVRFKDRISPKFQYLASAPVADPDGKPTVVRFSRKTKENYVRTEVDGKPSGWTALYIDGKWEVTDKRKKPKEK
(1104) DNA topoisomerase 3 [Vibrio furnissii NCTC 11218]
10
MTRLFIAEKPSLGRAIADALPKPHKKDQGFIRCANGDVVTWCIGHLLEQVEPDVYDERYKKWNLADLPIVPEQWQLRARKSASKQLSVVKKLLKEANHIVHAGDPDREGQLLVDEVIDYCKVAKSKKESMERLLISDLNLPAVKRALTSMRSNRDFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPRDYFTLDALIPYQDANGAFDIRARWKPSDACKPWQDEEGRVLNRKLVENVASRIAGQPAKVVESEQNQTKQSAPLPYSLSALQIDAAKRFNMSAQQVLDTCQSLYEKHKLITYPRSDCRYLPKEHFAQAPSVTAAIANNANELAGAVANADLSRKSKAWNDAKVDAHHAIIPTPKQASVNALSSYEMKVYQLIARQYLMQFYPPAVYAEAKLVFDIAGGTFVAKGRQLLSAGWKTLTGQKEEQEEGVDTVPPLPVGTVLTCREGEIKDRKTEPPRHFTEATLLQAMTGIARFVADKELKKILRDTDGLGTEATRAGILDTLFKRQLLIREGKLIKSSAAGRGLIHALPSDATYPDMTAHWEHQLQAMAERGQAYQPFMQALQQRIDQLMAQVKTGPVPESLRALPKVERPAFKRKRRTSSNRSQPKGKSRT
(341) DNA topoisomerase 1 [Vibrio furnissii NCTC 11218]
9
MEEKARLKKEKDKAALIKKMGVDPYHGWEANYQILPGKEKVVAELQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEERYKRVVFNEITKNAIQQAFQQPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDIHADTKTPSKEDFRLLVAQKDGVAFKPSNEAEAMAAMSVLQKAAYEVCKREDKPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVDAVRQYITSEFGEAYLPGKPNVYGSKEGAQEAHEAIRPSDVAVKADALEGMEADAHKLYALIWNQFVSCQMTPAKYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDQILPAVEVGETLSLEKLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFEDLMNYDFTARMEQKLDQIAEGETSWKGVLDNFFEDFSHNLETAEQDEDHGGMKPNHIVMTNILCPTCSRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEDGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGYIVEQGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILRNGEVAPPKEDPVHFPELPCENSDAYFVLRDGASGLFLAASNFPKSRETRAPLVEELAKYKDRLPEKYQYLADAPAQDPDGLKAVVRFSRKSKEHYVRTETDGKPSGWTALYNDGHWDITDKRKKAK
(251) DNA topoisomerase 3 [Vibrio fischeri ES114]
10
MLFTTSAFFMSRLFIAEKPSLGRAIAAGLAKPQKNQQGYIECGNGDIVTWCIGHLLEQVEPDAYDDKYKSWRMEHLPIVPDQWQLRPRKASSKQLTVIRKLLKNATQIVHAGDPDREGQLLVDEVLDYLKLSKTKKAATQRLLISDLNLPAVKRALTSMRSNQEFIPLSISALARSRADWLYGMNMTRAYTLLGQRGGYQGVLSVGRVQTPVLGLVTRRDEEIANFVPKAYYTLDALIPYQNDQLNDGVPFDIRAKWKPSDACQPWQDEEGRVLNLKLVENVAQRIANQPATVTKAENKETKQNAPLPYSLSSLQIDAAKRYGLSAQQVLDACQALYEKHKLITYPRSDSRHLPKDHYKQREQVCAAIGNNDKQLSTAVTKADFSLKSRAWNDSKVDAHHAIIPTPKSSSSAGLSGYEEKVYHLIARQYLMQFYPAAVYAEAELVFDIAGGVFVAKGKQMLFAGWRVLLGKVQSQNSDDDVASKVPPLSKGEVHTCREGEIKHRMTEPPKHFTEATLLQAMTGIARFVEDKELKKILRDTDGLGTEATRAGILDTLFKRQLLTRNGKSIHASEAGRGLIHALPNEATYPDMTAHWEFQLQGMTEKTHAYRPFMSELEIKVTNFMQGVQQGPVPESLRTLKSPAKPQFKRKRKAKKS
(1523) DNA topoisomerase 1 [Vibrio fischeri ES114]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPMGSTSTGKKAAASTKGLSVEEKARIKKERDKKNLINKMGIDPYNDWAANYQILPGKEKVVAELQKLAESADTVYLATDLDREGEAIAWHLREIIGGDDSRFKRVVFNEITKNAIQQAFETPGELSMPGVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVKVLVEREREINAFIPEEFWDIHADTLTADKENFRLQVAQRNGSAFKPLNQADTEAAVSILQNAEYEVCKREDRPTKSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKEAVEALREFIGSEYGDSYLPAAPIVYGSKEGAQEAHEAIRPSSVEVKADDLQGMEADAHKLYNLIWNQFVACQMTPAQYDSTTLSVKADEFTLKAKGRILKFDGWTRVQRPMGKNEDQLLPAVQLGDKLKLEKLDPKQHFTKPPARFTEAALVKELEKKGIGRPSTYASIISTIQDRGYVRIDNRRFYAEKMGEIVTDRLNQSFDDLMDYDFTARMEGNLDRIAEGEKDWKDVLNTFFQDFTADIAKAELDESEGGMSPNNIVETDIKCPTCGRNMGIRTASTGVFLGCSGYALPPKERCKTTINLGSEEGIVNVLEEDVETAALRAKKRCPKCETAMDPYLIDQERKIHVCGNNPNCEGYVVEKGEFQLKGYDGPVVECDKCGSDMELKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHLPELVCEKSDAYFVLRDGASGLFLAASTFPKSRETRAPLVEELVRFKDRLSPKFLYLTEAPTHDPDGKPAVVRFSRKTKENYVRSEVDGKPTGWTGLYIDGKWAITDKRKKPKAEK
(1225) DNA topoisomerase [Chromohalobacter salexigens DSM 3043]
3
MRLIIAEKPSLARAIADALPTAPQRHEGYLVCGETCISWCVGHLLEQAPPDAYDARYQQWRLDHLPIVPRQWKLIPRSKARAQLAVIRKLLKRADTVVHAGDPDREGQLLVQQVIAHLGWRGSISRLLVSDLNRPAVRQALQCIEDNARYQSLFEAAEARSRADWVYGINLSRAWTLTGRQAGYQGVLSVGRVQTPVLGLIVRRDLDIEAFTPRPFYPLWADLKVEHGTLRAWWQPQAPHPLDEQGRLLERAPAEALAAHLPGAEGHLSELQSKRQTQSAPLPYSLSALQVDAARRYKLPAKRVLDICQTLYERHQLITYPRSDCRYLPEGHFAAAKKTLDTACAQDATLRGWYQGADFSRRSRAWNDKQVGAHHALAPTGRTFDASRLTGDEANVFRLIARNVLAQFYSPLVTRDVKAAFSIHGEHFRAQGREILEPGWKPLFTTRDEAPPLPALHEGEAARVVDCAVEDRQTRPPDPFTDASLIKAMMNIARYVDDATVKRTLRDTDGLGTEATRAGIMETLVTRGYIVRQQGALRATRTGRALIQALPDTATRPERTALWEQRLADIAEGRGDADAFLDALVGDVRQLLDQADAARMRQALATTGGAEPSSPSRGKKRGTRRGSGDASSSPRRRAGKSTARRRTSSKKGQT
(607) DNA topoisomerase 1 [Chromohalobacter salexigens DSM 3043]
9
MGKSLVIVESPAKAKTINKYLGNDFVVKSSVGHIRDLPTSGSGKNATDPKERARQAAATRKMSPDEKAVYKKQKHWNQLVRRMGIDPEHGWEANYEVLPGKEKVVAELKKLAEKADAVYLATDLDREGEAIAWHLQETIGGDASRYRRVVFNEITKNAIQEAFKTPGDLDLSRVEAQQARRFLDRVVGFMLSPLLWSKIARGLSAGRVQSVAVRLIVEREREIRAFVPEEFWDVHADLLPASGEDTPIRFEVARHQGKAFRPTSEQETLERIAPLRDAALTITERETKPTRSKPNAPFITSTLQQAASGRLGFSVKKTMTLAQRLYEAGYITYMRTDSTNLSQDAVESARAFIGERFGQSYLPDAPNRYASKDGAQEAHEAIRPTEVTQAGDDLAVERDAQRLYELIWRQFVACQMVPAEYLATTLTIEAEGFELKARGRVLKFDGYTRVMKPAGKKEEDQSLPDLEEGAEMTLQALDPQQHFTKPAPRYTEASLVKELEKRGIGRPSTYASIISTIQDRGYVKLENRRFYAEKLGDIVTDRLAESFSDLMDYGFTARMEDHLDEIAAGNREWRELLDAFYAEFKAKLEHAEAEEGMRPNQPVPTDIDCPTCGRKMQIRTASTGVFLGCSGYNLPPKERCKTTIDLIAGDEAVAADADEEAETEALRAKRRCPECGTAMDSYLIDETRKLHICGNSPDCSGYEIEQGKFRIKGYDGPTIECDKCGSEMQLKSGRFGKYFGCTNENCKNTRKLLRNGEVAPPKMDPIPMPELACQKVEDHYVLRDGASGLFLAASQFPKNRETRAPLVKELKAHRDELPEKYHFLLDAPSEDPDGRDAQIRFSRKTKRQYVMSERDGKASGWRAEYEDGQWRVEDKRK
(1738) DNA topoisomerase [Marinomonas mediterranea MMB-1]
10
MILYIAEKPSLARAIAAALPSPQKKEDGCIWLPNGDCISWCIGHLLEQAEPHIYNPAYKSWSLDHLPIIPDDWQWQEKSQTKKQLSKLKKLIKQADQLVHAGDPDREGQLLVDEVLHYTNVPKKKLETTKRLLVSDLTPSSIKKSLGKLKLNSEYSALSRSALARARADWIYGLNLTRAYTIKGRQAGYQGVLSIGRVQTPILGLVVKRDLEIENFVTKDYFQVHAHLATEANEHFVANWVPSDACKPHMDEDGRVINRALAENVARRITHKPGTVVKAEYNTKRQSPPLPYSLSSLQIDAAKRWGLSAKQVLDTCQDLYEKHQMISYPRSDCRYLPVEQMSEISSIIKVLKSTSSEINNWCENANPHLKSSAWNDKKVGAHHAIIPTQKSGKYASLSHREKQVYELVVRQYLMQFYPNYEYLAAKIVAEIEGGTFSATGNTPLTLGWKSLLGATLNNDDKKTEETEPNLPKLTQGDPLFCRLGEVVQKQTKPPAHFTDATLLAAMTGIAKYVEDKSVKDILKETDGLGTEATRASIIELLFKRQFLFRDSKKIKATEAGRLFVSCLPRSTITPDMTAVWESTLSAISVKQASYEAFMTSLEATLTHLLNEARNTPLTSLTSLAKSTPAKTAWKARRSSSSRSSTKKEPTKRGSKGTGQKTTYKKKTTYKKSN
(1076) DNA topoisomerase 1 [Marinomonas mediterranea MMB-1]
9
MGKSLVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTGTTSKSTPQERAKQAALTRKMSPEEKAEYKSKKSRQQLIARMGVDPENNWEAHYEVLPGKEKVVDELKRLAKNADTIYLATDLDREGEAIAWHLREAIGGDEARYKRVVFNEITKNAIKSAFDEPSDLDMNRVNAQQARRFLDRVVGFMVSPLLWSKVARGLSAGRVQSVAVRLIVEREKDIRAFNPEEFWELDALLATASKEQVKFETLKYLGKEYRPTSQIESDEHVARIQNSGFVVSNREDKPTRSKPSAPFITSTLQQAASTRLSFGVKKTMMLAQRLYEGGYITYMRTDSTNLSNEAVEALRDFVGEKYGEAYLPKEPIRYSSKEGAQEAHEAIRPSDVTVTQNMLQGMDNDAHRLYELIRNQFIACQMTPAEYTSTSITVTAGDYELKARGRILRFDGYTRVLTPVGKKAEDMILPDIQKGDTLGLNELLPEQHFTRPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVDNRRFYAEKMGDIVTERLVGSFSQLMNFSFTAQMEEQLDEIAQGEDDWIRTLDAFYADFSNTLTKAEHPEEGMLQNQPTPTDVECPKCGRPMQIRTAATGVFLSCSGYALPPKERCKATINLVSGDEAVAVDDDEGESKALINKKRCKICDSAMDSYLMDETRKLHVCGNNPSCSGYEVEKGAFKIKGYDGPVIECDKCSSEMQLKTGRFGKYFGCTNEECKNTRKLLKNGEAAPPKMDPVAMPDLACQKVEDHYVLRDGATGLFLAASQFPRKRETRAPLVSELIPYMDQIDPKYHFFSDAPVMDNEGRPTVIRYSRKTKEQYVMTEENGKPTGWKAFHQNGKWVVEEGKKKK
(512) DNA topoisomerase 1 [Psychrobacter arcticus 273-4]
9
MTKPTTKKSAAPAADKPKGSPKGKSLVIVESPAKAKTINKYLGDDFIVRSSIGHVRDLPVGASKSAKKPATTKKDDILTKEEKTQQALVRRMGIDPEHDWAAVYEVLPNKTKVIKELKALAKDADKIYLATDMDREGEAIAWHLKEVIGGADSKYERVVFNEITKSAIQNAFKQPSKLDIDRVNAQQARRFLDRVVGFMVSPLLWQKVARGLSAGRVQSVAMRLVVEREHEIRAFIPEEYWQIHADTHIVDNKDKKATDAEQIGIRLEATKQGGKTLKLVNKEQTDKVLDVLKANDFIVKEREEKPTQSRPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSGDALAAVRGYIEDSYGAKYVPEKPTFYGNKQGAQEAHEAIRPSNVNMKSTQLKAVERDAIRLYELIWRQFVACQMLPAKYLSVNLFVAADDVELKARGRTLVFDGYTKVMPPAKTDDNLLPDVKKGDKLTVDKLDPSQHFTKPPPRYTEASLVKELEKKGIGRPSTYASIISTIQDRGYVKLENKRLFAEKMGDIVTDRLTASFPDLMDYTFTAALEDKLDHVAEGDTNWKDVLDNFYGDFKTTLDRAKEKDGMRPNDPTDVPDVHCDLCDRPMQLRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVEAFANLDDAEGDDEAAEVRDLMEKKRCPKCSTAMNGYIVDGGLKLHVCGNNPDCDGYVLEEGKFEVPGSDSPTIDCNKCDGQMELKTGRFGPYFACQQCDNTRKVLKTGEAAPPRMDPIHLPELKSVKHEDYFILREGAAGMFLAASKFPKVRETRPPKLAELREIKDKMEDKFQYLFEGPDEDPDGNPTILRWSRKKKEQYIGSEKNGKATRWGVYWRKGEWVEE
(59) DNA topoisomerase [Azotobacter vinelandii DJ]
4
MATMRLFLCEKPSQAKDIAKVLQATRRGDGCWLGPDLAVTWCIGHLLETAPPDAYDARYKRWDLSDLPIVPEHWKMLVKPKTASQYKVIKRLLGECRELIIATDADREGEMIARELVEHCRYRGPIRRLWLSALDDASIRKALAALKPGTETFSLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLSVGRVQTPTLRLVVDRDRSIADFVPVPWWAIEVQLLAEGTPFTAQWRAPEDACDDQGRCLKQELAQQAAQDMRHAGSARLVALKTERIREMPPLPFDLGTLQEICSKKLGLGAQETLDIAQALYETHKVITYPRSDCGYLPQSQHGEAPAILAALERTDPALAGLMHHIDPRRRSRAWNDARVGAHHGIIPTAAAQSLDRLVGKQCAVYTLIRARYLAQFLPNHEYDRTQADFDCAGHALRAVGKRIVEPGWRRALPEALTPAKGRETPPSQELPALREGQDCAVAEVTLKDLWTQPPKPYTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQALIERGYLLKQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMSLEAFVAKQSAWMSKLIERCAGLRLTISGPAAPVGRGAGPWKKKRKAGKPGAGGRRRARPAAPP
(413) DNA topoisomerase 1 [Azotobacter vinelandii DJ]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGSASTAKEPAKRGKGVAEGPALSPRDKAKRQLFARMGVDPEHGWQAHYEILPGKEKVVDELRRLAREADTIYLATDLDREGEAIAWHLRESIGGDEERYKRVVFNEITKKAIQEAFSQPGDLDINRVNAQQARRFLDRVVGYMVSPLLWQKIARGLSAGRVQSVAVKLIVEREREIRAFIPEEFWEVHADLGTARGDKVRFEVAREQGEVFRPLNEAQAMAALEKLKASSYQVLKREDKPTRSKPSAPFITSTLQQAASNRLGFSVKKTMMMAQRLYEAGYITYMRTDSTNLSADALEMARGFIDSEFGGKYLPAKPNVYTSKEGAQEAHEAIRPSDVNLRPNQLAGMERDAERLYELIWRQFVACQMPPAEYLSTNVSVQAGDFELRAKGRILKFDGYTRVLPQLAKPGEDDVLPEMSEGELLDLLKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQERGYVTLQNRRFHSEKMGEIVTERLGESFANLMDYGFTASMEEHLDDVAQGERDWKNLLDEFYGDFRRKLEAAESSEAGMRANQPTLTDIPCRECGRPMMIRTASTGVFLGCSGYNLPPKERCKATVNLIPGDEIAADDEGESESLLLRHKRRCPKCGTAMDAYLLDERHKLHICGNNPDCPGYEIEEGQYRIKGYEGPTLECDKCGSEMQLKTGRFGKFFGCTNAACKNTRKLLKNGEPAPPKMDAVKMPELRCEKVDDVYVLRDGASGLFLAASQFPKNRETRAPLVLELLPHRDEIDPKYHFLLEAPSHDPEGRPAVIRFSRKTKEQYVQSEVEGKPSGWRAFHRDGRWVVEDKH
(474) DNA topoisomerase [Pseudomonas putida S16]
4
MRLFLCEKPSQAKDIAKVLGANRKGDGCWQGTDVCVTWCIGHLLETAPPDSYDERYKRWNLADLPIIPEKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRYRGPVQRLWLSALDDASIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRGIADFVPVPFWAIDVQLEHAGFGFNAQWRAPDDACDDQGRCLNQALAQQAAVDIGNAGTARAVKVTTERVREAAPLPFDLGTLQELCSKKFGLGAQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILAALQRSDASLAPLQPYLEPQRRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQADFDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALREGQDCTVQGLQLKDLWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMTLEEFVARQSAWMGKLVERCSGMRMTISGPAAGAAPPWKKKRRGGGKGKAAAGKPRQPRKKATT
(603) DNA topoisomerase 1 [Pseudomonas putida S16]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKAAGEAPALSPKEKARRQLVARMGVDPDHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDTRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEIHADLGTAKNAKVRFEVAREKGEAFKPLNEAQAMAALEKLKASSYSVVKREDRPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADALDMARSYIEREFGKQYLPEAPLVYGSKEGAQEAHEAIRPSDVNTHPSKLSGMERDAERLYELIWRQFLACQMPPAQYLSTSVTVAAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMVQGEALKLIQIDPSQHFTKPPARFTEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVTLHNRRFYSEKMGDIVTERLSESFSNLMDYGFTADMEENLDDVAQGERDWKNVLDEFYGDFSKKLQTAESNEDGMRANQPTMTNIPCKECGRPMMIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESRVLLGKHRCPICATAMDAYLLDEKHKLHICGNNPDCAGYEIEEGNYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPACKNTRKLLKSGEAAPPKMDKVDMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVLEIVPHKHEIDPKYHFLCDAPQKDPEGRPAVIRYSRKTKEQYVQSEVDGKPTGWKAFYDGNAWKVEDKR
(275) DNA topoisomerase [Pseudomonas putida S16]
4
MRLYICEKPSQARDIARVLQAHRRGDGYLQGIGVTVTWCVGHLLETAPPETYSDQFKRWSLEHLPIIPQHWQLVVKPKVAAQLKAISRLLQACAEVVIATDADREGEMIAREILERCQYQGPILRLWLSALDDASIRRALTALRPGEQTLPLYHCALARSRADWLVGINLSRLFTLLGRRAGFDGTLPVGRVQTPTLRLVVERDRAIASFVARPFWTVDVVLHADGAEFEARWQPPAAHCDDAGHCVDQAAAEQVARRLAAARSVQVERVDVERVTEGPPLPFDLGTLQEVCSAKLGLGAQETLSVAQALYETHKATTYPRSDCGYLPESMLDEVPRVLKALAAADPALAQRFKEFDPTRRSRAWNSSKVTAHHGIIPTPVVIPLDQLSERERAVYTLIRARYLAQFLPHHEYLKTQVQLRSQADQVLARGKQIQVRGWKAVIDETDASEPTEQTQRLPTLQDGASVAAHDATINTQRTQPPKPYTEGTLVKAMKTIANQVADMRLKQTLKDSIGIGTEATRAAIIQGLIDHGYLTKKKRSLAASAAAHTLIEAVPREVADPVMTALWEQALARIETGQLSVEAFLAKQSAWLTQVVRSQASLNLQLPRSKGPACPVCRSPMRQRKGRTGNFWSCVRYPDCKGTKPVKASAAPAKPKRS
(1573) DNA topoisomerase 3 [Pectobacterium atrosepticum SCRI1043]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGQNDVVTWCVGHLLEQAQPDVYDARYARWSLADLPIIPQKWLLQPRPSVSKQLSAIKKLLNDASEVIHAGDPDREGQLLVDEVLDYLSLPEEKRQQVRRCLINDLNPQAVERAVSRLRENREFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVSKDYFEVKAHIVTPADERFVAIWQPSESCEPYQDEEGRLLHRSLADHVVKRIDGQPAFVTSYNDKRESETAPLPYSLSTLQIEAAKRFGLSAQQVLDVCQKLYETHKLITYPRSDSRYLPEEHFTGRHAVLNAIAVHQPDLLPQPVMDIDRRNRCWDDGKVDAHHAIIPTARSASASLTENERKVYGLVARQYIMQFCPDAVFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGGKERNEENEGMPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRTFLFKKARYIHASEAGRALIHSLPASAAHPDMTAHWEATLTQISEKKCRYQDFMQPLTNSLQELIQQAKQNGAVRAFKGFSAPPSGASKRRKPQAKKAKEQDQ
(380) DNA topoisomerase [Pectobacterium atrosepticum SCRI1043]
7
MMRLFLCEKPSQGRDIARFIGATQRGKGFLSGTGTVVTWAFGHLLEVASPEEYGAQFGKPWRMDVLPILPTEWKMVVKQSSADQFAVISRLLKQADEVVIATDADREGEVLARELLDYCHFTGNVKRLWLSALDDASIRKGLDNLLPGEKTVRLYYAGMGRSKADWLIGMNLTRIYTLKASEQGIDELLSIGRVQTPTLALVVQRDSDIENFSPKPYWQVFADIEKAGMTFRAQWVPAAGYCDDEKRCIQHNAALAVEQLCKQTATTSVVDVLLKREKTPAPLCFSLSVLQKACSDKWGMIAQKVLEIAQSLYEVHKATTYPRTDCGYLPESMKGEVSDVLSAILQSDPAATSLIKDADRSFVSRIWNDKKISAHHAIIPTKQPFDISKLSDDELNVYQLIRLHYFAQFFPLHESDVTDVTFNLGGQLFKTRGRVSVVIGWKKLFFNDKEPDIQSDENGSQGSLPVLHNGDICNVLDCEVKAQQTKPPSRFTDGTLIDAMKNSASFISDPTLKKILRDNAGLGTEATRANILDVLFKRNYLKRREKFIYSTQLARELISQLPEALTNPGMTALWEQALDDVAEGRMSLDAFLQKQKEWTLRLVDRGRQQAIKLTAPVSPLCPQCGGIMRKRNSDNGVFWGCVKYPLCKGIISEGTKGKRGKKNLKTKNKPAT
(835) DNA topoisomerase 1 [Pectobacterium atrosepticum SCRI1043]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSVSKKSADSTTKDKTKKKVKKDEKSALVNRMGVDPYHGWEANYEILPGKEKVVSELKALAENADHIYLATDLDREGEAIAWHLREIIGGDDQRFSRVVFNEITKNAITQAFEKPDTLNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVDREREIKAFVPEEYWELHADLLAGSDIQLQMQVTHHNGKPFKPVNKEQTHAAVSLLENARYVVADREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALTMVRGYIGEEFGKRYLPEAATGYSNKENSQEAHEAIRPSDVGVLADSLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLIVEAADYQLRAKGRTLRFDGWTKVMPALRKNDEDRTLPTVAVGEGLSLQKLLPGQHFTKPPARYSDASLVKELEKRGIGRPSTYASIISTIQDRGYVRAENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESRLDQVANNQAEWKAVLDEFFNEFSQQLEKAEQDPEEGGMRPNAMVLTSIDCPTCSRQMGIRTASTGVFLGCSGYALPPKERCKTTINLIPETEVLNVLEGDEAETNALRARRRCEKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEAGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTGETCSNTRKILRNGDVAPPKEDPVPLPELSCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELDRFKDRLPEKLRYLADAPVADKDGNKTQVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEGKK
(429) DNA topoisomerase 1 [Thiobacillus denitrificans ATCC 25259]
1
MSKLVIVESPSKSKSLKKYLGADYDILASYGHVRDLEPRTGAVDTENFSMKYQIIERNAKHVDAIVKAAKKADEVLLATDPDREGEAISWHISEILKEKKVKTPMKRVAFYEITESAIQDAVRNPREIASDLVDAQQARRALDYLVGFNLSPLLWKKISPGLSAGRVQSPALRMIVEREEEIEAFVAREYWTLHLDSHKGSQAFTAKLTHFKGEKLDQFAVEHEARSKEWLATLESKDARVMRIEKKRRARNPAAPFTTSTLQQAGVRQLGMTTDRVMRTAQQLYEGIDLGEGPVGLITYMRTDSVNLAQEAITDIRKYVGANFDKDYLPPHAVQYKAKTKNAQEAHEAVRPTSVLRTPDAVRQFLTQDQARLYELVWKRTVACQMTAAQFDTVAADITVGEGTFRATGQTLAFAGFLAVYQDDEDDEGESKLPALVEGETLPVDRLYGEQHFTQPPPRYTEASLVKALEEYGIGRPSTYASIISTLQDREYVVLEKKRFQPTDVGRLVNCFLTRHFSHYVDYDFTAKLEDKLDDVSNGKRVWSRLLGEFWSGFEGDLKAKQDVERGCPILEACPKCAKPLFMQASKRGLFIGCSGYPECDYTRPLHPATAEGDNILGKDPASGLDVKLLSGRFGPYVQIGDMPEDKKAPKPRRASWPKDIPLENATLDLALKFLSLPREVGHHPTTGLPIVANNGRFGPYLLHDGKFKSIPKTDSVYEIDLPRALEVLAMERAPRGADSAASVLKNLGPHPEDGKDITVRSGRYGPYVKHGSTNATLPKDITPEAVTLDEAIGLIAARVAKGPAKKPPRKAPTKASATKTKAADTATKPAATKKAATKKAPAKPAATKKPASKKAA
(317) DNA topoisomerase 1 [Sodalis glossinidius str. 'morsitans']
9
MGKALVIVESPAKAKTINKYLGKDYVVKSSVGHIRDLPTSGSASQKSTDASKKKKGKPDAQLALVNRMGIDPYHGWKARYEILPGKEKVVTELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITRNAITQAFEQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELHADLKTAQAAPLAMQVTHQREKPFKPVNQQQIQAALDGLENADYVVSDRDDKPTSSKPGAPFTTSTLQQAASTRLGYGVKKTMTLAQRLYEAGHITYMRTDSTNLSQDALNMARGYISASFGSPYLPKQANDYASKNNAQEAHEAIRPSDVNALAEQLKDMEADVQKLYQLIWRQFVACQMTPAQYDSTTLTVTAGEFQLRARGRTLRFDGWTKVMPALRKGDEDRTLPAVEAGQTLTLIKLLPSQHFTKPPARYSEASLVKELEKRGIGRPSTYVSIISTIQDRGYVHAENRRFYAEKMGEIVTDRLEENFRELMNYNFTAKMEDTLDQVAANQQEWKQVLDAFFQEFSQQLENAEKDPEDGGMRPNQMVMASINCPVCGRKMGIRTASTGVFLGCSGYALPPKERCKNTINLIPESETLNVLEGDDAETNALRARRRCGKCGTAMDSYVIDGQRKLHVCGNNPLCDGYDIEQGEFRIKGYDGPVVECEKCGADMHLKLGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELLCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVAELARFRDRLPENLRYLADAPVKDDEGDSTLVRFSRKTKQQYVSSEKDGKATGWTAFYIDGEWQVTKK
(649) DNA topoisomerase 3 [Sodalis glossinidius str. 'morsitans']
10
MQLFIAEKPSLARAIADVLPKPHRRGDGYIACGPDHVVTWCIGHLLEQAQPDVYDGRYARWSLADLPIIPEKWRLQPRPSVQKQLDVIKTLLAKAERVIHAGDPDREGQLLVDEVLDYLALDEAKRRDAKRCLVNDLNPQAVSKAVSRLRENSEFVPLCVSALARARADWLYGINMTRAYTLIGLNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPKAYFEVKAHIVTPSQERFIALWVPSDACESWQDEEGRLLHRPLAEHVVARITSQPAYVMLYQDKRESEAAPLPFSLSALQIEAAKRFGLSAQQVLDTCQRLYETHKLITYPRSDCRYLSEEHFAGRQAVLAAIAAHQPALMTQGQLNTDQRNRCWNDKKVDAHHAIIPTARTSRATLNDSEQKIYALVARQYLMQFCADAVFRRCIIELDIAGGKFFVRARFLAEAGWRALLGAKERDEEDEGTPLPVVAKGDALLCECGEVVARETQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIELLFKRGFLFKQGRYIHASETGRGLIHALPPSAASPDMTAQWEASLTQISEKQCRYQDFMQPLTHTLQQLIEQARQQPAPSSLRGLPPASEKPALKQARRKRKPP
(73) DNA topoisomerase [Acidithiobacillus caldus SM-1]
3
MSTVVIAEKPSMARAIQEGLGQQANRYEITNAFGHILEQAEPDAYLPGDVPKTAKGKKIWRMQDLPILPAEWKKFPKRDAKDQLAKIGALLKSADTVINAGDPDREGQLLIDEILEHFHYRGKVLRVWLKALDAENVRKAFAALESNEKYRPLKDAAEARSQSDWVVGMNLTRAVTVKSGDLFSIGRVQTPTLAIVVRRDLEIENFVPKDYFEVFAQCRHAQGAFLAKWEPSSTDGPGFDEEGRLIDKRLAEAIAQKAKGAGKVARFEAKEQKQSAPLPYSLSALQKVASSRFGMSAQQVLDTCQSLYEKKITSYPRTDCRYLPEEQLVDAPRILGKLPIPDGIRPLLNPRQKHVAWNNAKITAHNAIVPTGEPARGLSDAEAKLYDLIWKSYVALFLPDYRYRALSATIALGGESWKATGRQDIDLGWKKLFGAQALEDDEDADAARAPLPVMQTGDPVQGDGGKVEARQTKPPARFTDGSLIDAMSNIHKFVTDPQAKAKLKETSGLGTEATRASVLETLLQREYLQKKGKQLISTPKGRALIAYLEKQRLGSFADPVTTARWEDVLGMVAEGKVPMQKFTTAVTQEVAKAIEVLKSGSAMAGGGNATQQPLRAQPCPICGGDAVVRRLQSKKNRKVFFWSCSNRDAHPLLQDDNGKPGKPFEERKEDSGPPGPACPHCAGTATRTKTTSTGKTYYRCPSCQAAFWPDREDPQRLGAPWPPAENGGRRGSGATRSSSAKRSSGGDPSAPKTRSSTGGKKSASSGARGGKGRKSG
(1861) DNA topoisomerase 1 [Acidithiobacillus caldus SM-1]
1
MGQQLVVVESPAKAKTIEKYLGKDFTVLASYGHVRDLLPKEGAVDTEHGFAMRYAEIERNRRHVDAIAKALRSADALWLATDPDREGEAISWHLVELLREKGLLKDRAVHRVVFHEITQKAVREAIAHPREIAGDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLVCEREDEIEAFVRQEYWTIGAHLRRGEDPFTARLTHWQQQKLEQFDIVDGERAEEIRQAILADIAAGGLRVRKVERKNRQRQPAAPFTTSTLQQEASRKLGFSASRTMRVAQQLYEGVSIGTETVGLITYMRTDAVNLAEEALTSLRSFILGHYGADFLPAEARRYQTKSKNAQEAHEAIRPTDVQRTPEKLRGVLERDLWRLYDLIWKRAVACQMAAARLDLVAADLDADSHWTLRANGSTVTFPGFMAVYLEGRDEAAEEDEERLLPPLREGESVAVDAVLGEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVEVQQRRFVPTDLGRVVGRFLIQHFERYVDYGFTAAMEDELDAIARGEKQWQPVLAQFWGPFHELLEEKANVSRQEATSEALDEDCPECGKKLLVKLGRHGRFIACSGFPECHYARPLDGPRDAPEPVGRDCPDCGQPLVYKTGRYGRFISCSAYPQCKYIEALNKPKGTGITCPQCKVGELVEKRSRYGKIFYSCDTYPKCSYALWGPPLQRPCPRCAWPILYQKSTKRRGEELVCPQAECAFHFPAAAEDAEVQRLLADYTPPPPKDDADAAARPRRAAKTVKKAAAGPKSAAAAKTVRSKPTSRTANKSKTSKKPTVKA
(453) DNA topoisomerase III [Acidithiobacillus caldus SM-1]
7
MFIAEKPSLGKGIAKYLSGSASSGKGYIQCGPDVVTWCFGHVFEQVEPDYYLPDDVPLANNGKKKWRFEDLPIFPEHWKLEAKDDAKAQIKVIRDLLKKADVVVNAGDPDREGQLLVDEVLEELGWKGPTQRIWLAALDEQSVKKALSSIRDNREYQNLCNAARARSRADWLVGMNLSRAFTLRNSGGGVVSIGRVQTPTLALIVARDEKIENFQPKEYFVPRIHTGFWSSWELHEDFSGVDGEGYLTDCKAADSLIARAQAEGRAVVQEYESREKQQSATLGFSLAELQKVCSAKLGMSAQQVLDAAQALYETHKCATYPRTDCRYLPEEQFAEASRVLSGLARLGFGDLVKNADAARKSSIWNTGKVTAHHAIIPTGGMESRPEGATAKVYEIIVRSYLAQFYPPYVFRAIKAVLGCAGESWKATANVPVAPGWKAVYGLSEEEGEAAQQPIPVLQTGQVLPVQDADVQAKQTKPPARFTDGSLIEAMSNIHKFIEDEAAKAKLKEASGLGTEATRASILETLLGRGFVERKGKQLISTRAGRELVKALPRELTDPVTTAKWEDALSLIAEGKLTLEQFEEVQRAVVARHIAAAKSSHFTVGEARSRNGKGAATGKARKLGPTCAACKQSKTVVLRAKSGKNWLKCEACGAAFWPEKNGKGCGTPWEARA
(820) DNA topoisomerase 1 [Neorickettsia sennetsu str. Miyayama]
1
MNVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKGSVDVTESFEMLYKLTDTGETVVPQLIKDVKKATALYLATDPDREGEAISWHLVEVFKENDVLPKDVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSISPVLWKKLPGSKSAGRVQSVALRILCDRENEIGLFTPEEYWTVTVNMTDGEALVLPTQLSHMNGEKLERMSIRRAEEAEKIVEEISGLPFLVEEIKKKELKQKPSPPFITSTMQQTASTILGFSVKKTMSLAQKLYEGIEIGGVIEGLITYMRTDATHLSVESVDAIREFIQEKFGQEYLPASPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAITSSQNIVFVSQDKKFKTSASASLLIFDGFNAAFSHGKNKNKNQDVIDFIKKHKEGAQVKVGDVLLTQNFTEPPHRYSEAGLVKHLEELGIGRPSTYATVVSVLQERGYASIVNKSFIPESRGRLVSEFLVHFFSKYVEYHFTAELEDRLDKVADGTIFWLDVIQDFWDSFHSNVEEVEKVPITEVLAFVNGALARQKLVSAEVKVGDKCPKCEKGYMHLNVSRYGVFLGCTDYPVCRFIVNSYSTDNDTEYPKQIAQDISLHKGPYGIYLKCKGKNSSIPKDVDPVSIDEEFAHKIASLPKILGKHPIDGKEIKMGLGPYGLYLFWNAKYYNLQFSQMDEMTLDQAVQFMEDYVSHDKSLLRVLGSHEGEEIQIRDGRYGPYIKYSKMNVPIPKGESPESLSLETAILLIEKKKNTSKSARKVTTKRKVFTKEKK
(477) DNA topoisomerase 1 [Candidatus Midichloria mitochondrii IricVA]
1
MNLLIVESPAKAKTIGKYLGPSYKVISSYGHVRALPSEEGAVDPEHDFAMRYEIPPKAAKQIAAIVAEAKHSDHIYLATDPDREGEAISWHVLEILKQKKAIKNSTKVYRAVFHEITKKAIADSLKTPRDLNNDLVSAQKTRQGLDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRMICEREAEIESFKSQEYWSIHGRFSTEKGEEFDSTLIEFQGKKLEKFTTVNEAQAADVISKIKDNSFSVKRVEKKKVNRNPQAPFSTSTMIQEASRKLGFSAKKTAQIAQKLYEGININGELTGLITYMRTDSTSISAEATKAASELITKIYGSNYLPPSPRVYKTKTKNAQEAHEAIRPTDVFKKPESIKSFLEEDQFKLYELIWNRLVASQMASAILDVMTVDIADDQGNTFRATGSSIAFSGFYKVYREGIDDADEEKDRILPILKEKELLKLLEAIKEQHFTQPPPRYTEASLVKRMEELGIGRPSTYPTIISILQDRKYVIFEKKRFIPEPRGRLVNTFLTLFFNQYVEYGFTANLEEQLDEIAAGKVIWKKVMKDFWYPFKNKTDEVLSIKTSEILAKMEEQLLNYLFHKEILQDSKSIEEVLKCSKCVTGKLQLKNGRFGSFLACSNYPNCNYTKAIGSNDNNMQDTCNEPAVADLPKVLGTDPNTKEEVSIRKGPYGFYVQRGEGKKVKRTGLPKDLNYQNIDLNYAIGLLNMPRELGLDQEGVLIRAGAGKFGPYLERSGKYISLRTARIDPVLITLEEALGIIKKSSSDKKDKSSQGKRSAKATI
(796) DNA topoisomerase 1 [Novosphingobium sp. PP1Y]
1
MQLVIVESPAKAKTIEKYLGKDFKVLASYGHVRDLPPKDGSVRPDEGFEMDWELYGDKQKQVRAITDAAKVSDRLILATDPDREGEAISWHVLELLKKRRALPKDVQRVTFNAITKDTVTKAMQAPRELDQDLIDAYLARRALDYLFGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDREREIEAFRPQEYWSVAAHMEQDGTPFTAKLVAFEGQKLDRLSLGDEGIAMRAKAAVEQGAFKVENVETKPHRRNPQPPFTTSTLQQEASRKLGFSASQTMRVAQSLYEAGAITYMRTDGVQMDPSAISACRKAISDRYDGHYLPEKPRHYETKAKNAQEAHEAIRPTEFTRDRFGSGDEARLYDLIFKRAMASQMASAALERTTITLRDGTGRNELRATGQVVKFPGFLAVYEEGRDQKDDDEESGLLPMMRSGDAPAKKDVTAEQHFTQPPPRFSEASLVKRLEELGIGRPSTYAATIQVLKDRNYVRTEKNRFFAEESGRLLTAFLERFFERYVAYDFTAGMEEELDDVSGGRHAWKELLEAFWRDFKPKSDEVMERKPSEVTEVLDEFLSDYLFPPKDDGSDPRACPKCADGRLALRGGRYGAFVACSNYPECKFTRKFAQPGGNGETADDEELGKHPETGEEITRRVGRFGPYIQLGEGKEAKRASIPKDIDELTLDWALKLLSLPREVGKHPETGKEIVANIGRYGPYLLHDGKYGKLRSTADVFETGMNAAVSILAEAAQGGGRGQRAKAEPIKVLGKHPTSEGEIKVLAGRYGPYVTDGTTNATLPRDQKPEELTAEQAIALIDAKAAKGPAKGKKKASAKKAPAKKATAKKAAGKSGEAKTATKKAPARKASVTKTSNDTSEQDGEVPWDVDA
(1221) DNA topoisomerase 1 [Sphingomonas wittichii RW1]
1
MKLVVVESPAKAKTIEKYLGPGHRVLASYGHVRDLPAKDGSVDPDNGFAMEWEAYADKSRQLKAIADEAKGADTLILATDPDREGEAISWHVKEVLGKRRVLPKDVRRVTFNAITKAAVTEAMANPRDLDEDLIDAYRARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVALRLVVDREREIELFKAQEYWSVTADMEYDGIGFLTRLVRWKGQKIDRLTIGNGKDAEAAKADVEAGRFTVASVETKPLTRNPPPPFTTSTLQQEAARKLGFSASHTMRIAQALYEDGAITYMRTDGVQMDGSAISAARGAIANRYDASYVPDKPRQYSAKAKNAQEAHEAIRPTDFSRDRAGSGDHGRLYDLIFKRALASQMASARLERTTVDLVDGTGQNALRATGQVVLFPGYLALYEEGRDDPNPQGQQAGGGDADEDSRRLPRMKEGDSPAKKKVDAEQHFTQPPPRYSEASLVKKMEELGIGRPSTYASILQTLKDRDYVTVEKNRFTPNESGRLVTSFLERFFERYVSYDYTAHLEEELDDVSGGRAGWQQVLEAFWKDFKPKTAEVMDQKPSEVTAALDEFLAPYLFPDKGDGTDPRLCPVCQEGRLSLRGGRFGAFIACSNYPECKFTRRFAQAGAANDGADTGPVVIGTDPATGLEVSKRAGRFGPYIQLGDGKDAKRSSIPKDVLGDDLDLGWALKLLSLPRLIGPHPETGHPITASIGRFGPYLAHDGKYARLGSTAEVFETGMNAAVVKLAEAANGGGRQRGKAEPLKTFGASPVTGSEVKLMAGRFGPYVTDGETNATLPKTANPDELTAEAALELLAARAAKGPPAKGKKKAPAKKAAPKKAAAKK
(419) DNA topoisomerase 1 [Brevundimonas subvibrioides ATCC 15264]
1
MNLVIVESPAKAKTINKYLGSGFEVLASYGHIRDLPSKDGSVKPDEDFAMEWEVDARASTRMTEIAAAAKRADRVILATDPDREGEAISWHVLEVLNKKKAIKDTPVERVTFNAITKSAVLEAMANPRQIDMELVEAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIVVDRELEIERFRPQEYWSIEADLAADSPPFTTRLVKHAGKRIQRLDIKDEATANAARDAIQTGDFTIRSIEKKPVRRFPSPPFTTSTLQQEASRKLGFDAQRTMRAAQKLYEGVDETGGLITYMRTDGVQTTPEGIAQAREVIGETFGPAFVPAEARYYKTKAKNAQEAHEAIRPTNIARRPDSLRLESDLQRLYELIWKRMVASQMEAARLDRTTVEVETPDGQTGLRATGQVVTFDGFLAVYEEGRDEKQKGAESEEDDDTARLPTLKEGAKAKVEAIRTDQHFTEPPPRYSEATLVKKLEELGIGRPSTYASILTTLRDREYVRMDKNRFIPEDNGRLVTAFLEQFFGRWVEYDFTAALENQLDEVSAGDMDWKALLREFWSKLKPATAAVLERQGVIDELDTAIGPFLFPEKADGSDARLCPLCKTGHLHLKASFKMKSSFIGCSNYPECRYTRGFGAGENAGDEAGGDRELGIDEATGLPVALKIGRFGPYVETANPGEEKPKRSSLPKGWSPATLTLEQAVRLLALPRPVGDHPEDGKPITAGLGRYGPFILHAGTYANVADIDEVFDIGLNRAVVLLAEKRAGKFAGRGAAVAPLKDLGAHPESGEPVHVMAGRFGPYVKSGKINATLPKGTAPEDMTMEIAVPLLAARALVAPKAKKAPAKKAAPKTAAAKKPAAAKKPAAKKPAAKKTKTVA
(1531) DNA topoisomerase 1 [Pectobacterium carotovorum subsp. carotovorum PC1]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSVSKKSADSTTKDKTKKKVKKDEKSALVNRMGVDPYHGWQANYEILPGKEKVVSELKTLAENADHIYLATDLDREGEAIAWHLREIIGGEDERFSRVVFNEITKNAIKQAFEKPDTLNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVDREREIKAFVPEEYWELHADLLAGSDIQLQMQVTHHSGKPFKPVNKEQTQAAVSLLENARYVVADREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALTMVRGYIGEEFGKRYLPESANLYSSKENSQEAHEAIRPSDVGVLADSLKDMETDAQKLYQLIWRQFVACQMTPAQYDSTTLIVEAADYQLRAKGRTLRFDGWTKVMPALRKNDEDRTLPTVAVGEALSLQKLLPGQHFTKPPARYSDASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESRLDQVANNQAEWKAVLDEFFNEFSQQLEKAEQDPEEGGMRPNAMVLTSIDCPTCSRQMGIRTASTGVFLGCSGYALSPKERCKTTINLIPENEVLNVLEGDDAETNALRARRRCEKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIETGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTSETCSNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLAEAPVVDKDGNKTQVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEGKK
(1549) DNA topoisomerase 3 [Pectobacterium carotovorum subsp. carotovorum PC1]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGQNDVVTWCVGHLLEQAQPDVYDARYARWSLADLPIIPQKWLLQPRPSVSKQLNTIKKLLNDANEVIHAGDPDREGQLLVDEVLEYLALPEEKRQQVRRCLINDLNPQAVERAVSRLRENREFIPLCVSALARSRADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVAKDYFEVKAHIVTPADERFVALWQPSESCEPYQDEEGRLLHRSLAEHVVKRIEGQPAFVTSYNDKRESETAPLPYSLSTLQIEAAKRFGLSAQQVLDVCQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISVHQPDLLPQPVMDVDRRNRCWDDGKVDAHHAIIPTARSASASLTENERKVYGLVARQYIMQFCPDAVFRKCVIELDIAGGKFITKARFLAEAGWRTLLGGKERDEENEGMPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRTFLFKKARYIHASEAGRALIHSLPASAAHPDMTAHWEATLTQISEKKCRYQDFMQPLTHSLQELIQQAKQNGAVRAFKGLSAPQSGAAKRRKPQTKKAKEQEQ
(1580) DNA topoisomerase [Parvibaculum lavamentivorans DS-1]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQLKRWSVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDACTDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAKFSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVADVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGSSKRGASRPRRSGRKGS
(46) DNA topoisomerase 1 [Parvibaculum lavamentivorans DS-1]
1
MDVVIVESPAKAKTINKYLGKGFKVLASYGHVRDLPSKDGSVLPDQDFAMAWDVDAKSQKRLNEIATAVKGADRLILATDPDREGEAISWHVLEVLNKKKVLKDVEVQRVVFNAITKKSVTEAMEHPRGLDKELIDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICDRELEIEAFRSQEYWTVEADMKTGGGSPFVARLTVLDGKKLDKFDIPDKKSADDIEARIKASRFSVKSVESKPTRRNPNPPFTTSTIQQEASRKLGFSASRTMQVAQRLYEGVEIDGETTGLITYMRTDGVQIAPEAIAQARTVINNEFGEAYLPDAPRVYTTKAKNAQEAHEAIRPTDLSRLPKHAAKYLDDDQRRLYELVWNRTIASQMESVQLERTTIEIEADDAPIGLRATGSVIVFDGFLRLYQEGRDEPDDGEDGGRLPKVARGDKLGLEKVRPEQHFTEPPPRFTEASIVKRMEELGIGRPSTYASTLQTLRDRDYVHMDKNRLVPQDKGRLVTAFLENFFTRYVEYDFTAELEEKLDKVSAGELDWKDLLREFWKEFTVNVAEALELRITEVLDRLNEVLGPHVFPEKEDGSNPRACPSCGNGILSLKVGRFGAFVGCSNYPDCKFTRQLTVGAEGEEQAGDRVLGTDPETGAEVSLKTGRFGPYVERAPLGDDEKPKRSGLPAKMSAADVDLDTALRLLTLPREIGIHPETGKKITAGLGRFGPFVLHDGTYANLKDPEELFDIGLNRAIAVLAEKVIRAEERAGKVLKELGDHPDTGKPVQVREGKYGPYIKHGTTNATLPKSADPAAVTLEEALALVAEKDAKSGKKKPAAKKAAKKPAAEKKPAAKKAPAKKPEKKKAPAKKKAPAKKPAAKARKTDKASELAD
(701) DNA topoisomerase 1 [Nitrobacter winogradskyi Nb-255]
1
MNIVIVESPAKAKTINKYLGTSYEVLASFGHVRDLPAKNGSVDPDANFQMIWEVDPKAAGRLNDIAKSLKGADKLILATDPDREGEAISWHVLEVLKQKRALKDQKIERVVFNAITKQAVTEAMKSPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRELEIEKFVPREYWSLVTTLATPRGETFDARLVGADGKKIQRLDIGNGAEAEDFRKAIEAANFTVSTVEAKPARRNPQAPFTTSTLQQEASRKLGFAPAHTMRIAQRLYEGIDVGGETTGLITYMRTDGVQIDGSAITQARKVIGEDYGHAYVPEAPRQYQTKAKNAQEAHEAIRPTDLSRRPSDMKRRLDADQARLYELIWIRTIASQMESAELERTTVDIAARAGARTLELRASGQVVKFDGFLALYQEGRDDEEDEDSRRLPAMSEGEALRRENLSVTQHFTEPPPRFSEASLVKRMEELGIGRPSTYASILQVLKDRGYVKLEKKRLYGEDKGRVVIAFLENFFARYVEYDFTANLEEQLDRISNNEVSWQQVLKDFWDDFIGVVNEIKDVRVSEVLDVLDNMLGPHIYAPREDGGDPRQCPTCGTGRLNLKAGKFGAFVGCSNYPECRHTRPLAADGEAGGDRVLGKDPESGLDVAVKSGRFGPYIQLGEASDYGEGEKPKRAGIPKNTSPADIELDLAVKLLSLPREIGKHPETGEPITAGIGRFGPFVRHEKTYASLEAGDEVFDIGLNRAVTLIAEKVAKGPSRRFGADPGKPLGDHPTLGPVAVKSGRYGAYVTAGGVNATIPSDKTQDTITLPEAIALIDERAAKGGGKPKRAAKKAKPAQTEKAGKDGAATKKPAKKAASKQASTKPKSEAVSKARGSIAAAKAPPNTVKAPTKKSAGKNG
(318) DNA topoisomerase 1 [Erythrobacter litoralis HTCC2594]
1
MQLVIVESPAKAKTIEKYLGKDFKVLASYGHVRDLPPKDGSVRPDEDFAMDWELYRDKQKRFKEISDAAKQADRLVLATDPDREGEAISWHVQELLAKRKALPAKVDRVTFNAITKSAVTEAMGRPRELDQPLIDAYLARRALDYLFGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDREREIEAFKPEEYWSVLARFEHDGTEFDARMVRFDGKKLDKMTLGNEGSALAAKAAVDAGRFTVSDIETKPLKRNPAPPFTTSTLQQEAARKLGFSASHTMRCAQSLYEAGAITYMRTDGVQMDGSAIAACRHAIEERYESAYLPEKPRFYATKAKNAQEAHEAIRPTNFNRDSAGSGDEAKLYGLIFKRAMASQMATAQLERTTITLEDPTGQHALRATGQVVKFPGFFAVYQEGFDDKSDEDEDGLLPAMHKGDAPAKKGVEANQHFTQPPPRFSEASLVKRLEELGIGRPSTYASTIQTLRDRDYVRMEKNRFFAEESGRLLTAFLERFFPNYVAYEFTAGMEEELDTVSDGREEYKELLAKFWADFKPKADEVMEKLPSEVTEVLDDYLSDYLFPPTEDGTEPRACPLCRDEGREGGRLALRGGRYGAFVACANYPECKYTRRFAQPGGNESAADDGIMGQHPETGEDIERKSGRFGPYVQMGEGKEAKRASIPKDLDDFDLDWAVKLLDLPRIVGAHPETGKEIEAAIGRYGPYLRHDGKYGKLQSTRDVFEVGMNAAVTILAEAANRKGGGRGKAEPIKTLGEHPTSGGEMKVMPGRYGPYVTDGTTNATIPKDMKPEDVSEAQAIELIDARAAKGPVKKKRKKAPAKKKAAPKKKAAAKK
(1645) DNA topoisomerase 3 [Yersinia pseudotuberculosis IP 32953]
10
MMRLFIAEKPSLARAIADILPKPHRRGGGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPAGPSGAPKKRKKISSKAKESKS
(1341) DNA topoisomerase 1 [Yersinia pseudotuberculosis IP 32953]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSANSAEEKAKKDDKPKKKVKKDEKVALVNRMGVDPYHGWKAQYEILPGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNISRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLVAKGDIPIQMEVTHAHGKPFKPVNREQTHAALTLLENARYKVLDREDKPTSSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPATPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQRLYQLIWRQFVACQMPPAKYDSTTLTVQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSDLDLQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESGLDQVANDQAEWKTVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVMTSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPDAEILNILEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEAGEFRIKGYEGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVVDKEGNKTLVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEAKK
(1381) DNA topoisomerase 1 [Roseobacter litoralis Och 149]
1
MPVVVVESPAKAKTINSYLGDNYTVLASYGHVRDLPPKDGSVDPDAGFEMLWEVGYDSRKHVKAIADALKEDNALILATDPDREGEAISWHLQEALTKRKSIKKDTPVSRVVFNAITKAAVTEAMQNPRQVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVTLRLIVEREMEIEAFRAREYWSVKALLATPRSQEFEARLTVLAGKKLDRFDIENQTQAELAVQAITSRDLSVKSVEAKPANRNPSAPFMTSTLQQEASRKFGMGARQTMSTAQRLYEAGYITYMRTDGIDMAPEAVSAARDAIKTLYGADYVPKSPRIYKNKAKNAQEAHECVRPTDMMTKAEDLKTSDADQRKLYDLIWKRTLACQMEAARLERTTAEIASEDGQIGLRATGQVMLFDGFLRVYEEGRDDVAVVDDDDKRLPQIGQGDRLDKRTVTPEQHFTQPPPRYTEATLVKRMEELGIGRPSTYASVVTTIQDREYVRKDKNRLIPEDKGRLVTAFLSNYFRKYVGYDFTADLEDQLDTVSAGNADYKEVLGRFWRDFSAAIAETADLRITEVLEKINEVLEPHLFPANEDGTDPRLCPNCGAGRLSMRTARSGGAFIGCSNYPECRYTRAFGPPGEEDDSGIPPEGKLLGEDGEDKIYAFKGRFGPYVQRGEVTEDNKKPPRQSIPKDWPPEDVDLPQALKLLSLPREIGPHPEDGITVWANIGRYGPYIKHAPSTSDRGGTNANLEGIDEVFTVGMNRAVQLLAEKLASRGQRGGAAKTLRDLGEHPEEGGPIAIMEGKYGPYVKWEKVNATLPKDSDPAGLTMEAAVALIDEKAASKGKKRRKAAPKKTAAKKTATKKAAPKKTAPKKKAQAKKAEE
(554) DNA topoisomerase 1 [Jannaschia sp. CCS1]
1
MPVVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPSKDGSVDPEEGFFMKWEIGSDSKKHVKAIVDALKDDNSLILATDPDREGEAISWHLQEALTSRKAIKTDTPVSRVTFNAITKDAVTKAMAEPRQVDMELVEAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVCLRLVVEREMEIEAFRPREYWSVRAVLETPRGQTIEARLTVLGGKKLDRYDLPSAAEAGLAVQAVSSRKLSVSDVEAKPANRNPSPPFMTSTLQQEASRKLGMGAKQAMSTAQRLYEAGHITYMRTDGIDMAPEAVEDARGAIKTRYGVDYVPGKPRIYKNKAKNAQEAHECVRPTDMSKAANDLKLSEDDQRKLYDLIWKRTIASQMEAARLERTTVTIASDDREVELRATGQVMLFDGFLKVYEEGRDDAGDDEDSKRLPQVSAGDPLKPSADAMADDYAKYSGDDVVEDDGNGDVRRSKSAILSREGAVLGQQHHTAPPPRYTEATLVKRMEELGIGRPSTYASIMDTIQNRGYVIKDKGRLIPEDKGRLVTVFLSNYFNRYVQYDFTADLEQQLDEVSAGDRHYKDVLDRFWRDFRAAIDETSDLRIGEVLDKINEVLEPHLFPDPGDGTDPRLCPNCGVGRLSMRTARAGGAFIGCSAYPECRYTRPFGPPDPEAEASAIPPDGKLLGEDQGDEIRIFKGRFGPYVQRGAMTEENKKPPRQSIPKDWTPEELDLERALMLLSLPRQIGPHPEDGIMVWSNIGRYGPYLKHAESTSDRGGTNANLDGLDEVFTVGMNRAVQLLAEKVASRGGRGQAAKPLRELGEHPDAGGPVNVMKGKYGPYVKWDKVNATIPEAIDPEAITMDQAVQLIEERAAKSGKKKPAAKKKTTAKKPAAKKKPAAKKTAKSAD
(1792) DNA topoisomerase 1 [Mesorhizobium loti MAFF303099]
1
MDVVVVESPAKAKTINKYLGKNYKVLASFGHVRDLPAKDGSVRPDEDFAMSWAVDTASGKRLADIAKAVKDADGLILATDPDREGEAISWHVLEVLKQKRALKDKPVSRVVFNAITKSSVLEAMANPRQIDAPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFIREEYWQIAAILGTPRNETFEARLTAFERKKLQKLDIANKAQADDIKAMLEGATFKALSVEAKPTKRNPGPPFTTSTLQQAASSGLGFSATRTMQVAQRLYEGMEIGGETTGLITYMRTDGVQMAPEAIDAARDAIAKEFGPKYLPEKPRFYTTKAKNAQEAHEAIRPTDFMRTPASVRQYLDSDQMRLYELIWKRAIASQMQPAEIERTTVEIEAVNGARTAELRAVGSVVRFDGFIAAYTDQKDDDAEDEENRRLPEIRAGEQLARQAINATQHTTEPPPRYSEATLIKKLEELGIGRPSTYTAILKTLEDRDYVTIDKRRLVPQAKGRLLSAFLESFFERYVEYDFTASLEEKLDEISDGKLAWKDVLRDFWKDFSGAVADIKELRVTDVLDALNEELAPLVFPAREDGSNPRICPKCGTGNLSLKLGKFGAFVGCSNYPECSFTRQLGDAANPNGENGGGDDGTKVLGKDPYTAEEITLRSGRFGPYLQRGDGKDAKRSSLPKGWTPETIDHEKALALLALPRDIGKHPETSKMISAGLGRYGPFVLHDGTYANLDSIEDVFSIGLNRAVTVIAEKQSKGKGGRNGGTPAALKELGDHPDGGGKIVVRDGKYGPYVNFGKVNATLPKGKDPQSVTIEDALALIAEKEAKGGGGKKPFRKAAAAKAPAAKKTAARKPAAKKKG
(1539) DNA topoisomerase 1 [Bartonella henselae str. Houston-1]
1
MNIVIVESPAKAKTINKYLGSQYKVVASFGHVRDLPAKDGSVLPDQDFSMKWDVDSAAAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDVLRQKKVLKDKPVKRVVFNAITKKSVLDAMNNPRDIDTSLVNAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSITTDLKTIRNDGFQARLTMFNQKKIGKLDIQSQEQADQIRLMLEKAKYHALSVEAKPTKRNPFPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGEMAGLITYMRTDGVQIAPEAIDSARKVIHESFGSDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRIPNQVRNFLDSDQAKLYELIWKRAVASQMRSAEIERTTVEIEAQQGENYANLRATGSVIRFDGFLSLYTDQRDEENNEENETTRLPQINTGEELTKEKVDAIQHTTEPPPRYSEASLIKKLEELGIGRPSTYASTLATLSDRGYIIIDKRKLIPDVKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRDFWDGFNASITNIQELRITNVLDVLNVTLAPLAFPVREDGSDVRSCPLCTNGQLSLKLGRYGAFVGCSNYPECKYTRQLGTDPGEENEAIRNDEPVILGVDPKTGKDVTLRNGRFGPYIQLGESKEAKRAGLPKEWQAEKITLEKALSLISLPREIGIHPETGKTITATIGRYGPYLTHDGKYAPLLNVDEVFDIGINRAVTVLAEKQENKTKRSRTTTAALATLGNHPDGGVVTVRNGRYGPYVNWGKVNATLPKDKDPINVTLSEALELISVKASGKKTTLKRASTKTKET
(540) DNA topoisomerase 1 [Beijerinckia indica subsp. indica ATCC 9039]
1
MNVVIVESPAKAKTINKYLGKDYEVFASFGHVRDLPPKDGSVDPDHDFAMLWDVDTKSAKRLADIAKAVKEADRVILATDPDREGEAISWHVLEVLKAKKVLKDKPVERVVFNAITQSAILDAMRHPRAIDIDLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCERELEIERFVPREYWSLTAFLRTPADQPFSAKLVGADGKKINRLDIGAGAEAEAFKAALETAKFTVAKVEAKPARRNPAPPFTTSTLQQEAARKLGLAPARTMQLAQRLYEGIDLDGETVGLITYMRTDGVDLAPEAITGARKVIAAEYGDKYVPQAPRRYQVKAKNAQEAHEAIRPTDLARLPKHVARFLDAEQARLYDLIWTRTIASQMESAELERTTVDILAEVGARRLDLRATGQVVRFDGFLKLYQEGRDDEEDEEGGRLPAMQVGDPLKKDRIEASQHFTEPPPRFTEATLVKRMEELGIGRPSTYASTLAVLKDREYVRIDKKRLIPEDKGRLVTAFLESFFGRYVGYDFTADLESSLDKISNHEIDWKQVLRDFWADFSGAIADTKDLRTTQVLDSLNEVLGPYIFPDKGDGSNPRACPSCANGQLSLKLGKFGSFIGCSNYPECKFTRTLSDTGPEGGNGETDRPGVKVLGVDAETGEEISLRDGRFGAYVQRGEGEKPKRASLPKTIAPADLTLDMALGLLSLPREVARHPETHEPILAGIGRFGPYVQHGKTYANIGKDEDILTLGANRAIDLIIAKESGLTGRRFGKGESAPARVLGDHPEGGQVTIKAGRFGPYVNYGKLNATLPKDADPTTLTLEEGLALLAAKASGQGGGKGAVQGQLLGEHPSGGPITVREGRFGPYVNHGKVNATLKSGLSPETLTLEEAIRLIDEKAGAASKKAPAKKAPAKKASGKTTTTEKAPAKKAASKAATAKTTKAKAAKSSEPDEEPPF
(1206) DNA topoisomerase 1 [Rhizobium leguminosarum bv. viciae 3841]
1
MNVVVVESPAKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVLPDQDFEMLWEVDSASAKRMKDIADALKSSDGLILATDPDREGEAISWHVLDMLNKKRALTGKSVKRVVFNAITKKAVLDAMAAPRDLDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFISEEYWNISALLKTPRGDEFEAKLVSASGKRLQPRAIGNGEDAGRLKALLEGASYVVDSVEAKPVKRNPGPPFTTSTLQQAASSNLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIDAARSAIVDQFGERYMPEKPRFYSTKAKNAQEAHEAIRPTDFDRSPDRVRKFLDADQIRLYELIWKRGIASQMASAEIERTTAEITADNKGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDEDGRLPEINAREALAKQKINSTQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLATLRDRDYVTIDKRKLIPQAKGRLVTAFLESFFTKYVEYDFTADLEEKLDRISAGELNWKQVLRDFWKDFFAQIEDTKELRVTNVLDSLNEALAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPDCNYTRQLSSENGGEADGAALNEPKNLGTDPTTGEELTLRSGRFGPYIQRGDGKEAKRASLPKGWKPEDIDYEKAMALISLPRDIGKHPESGKMISSGIGRYGPFLLHDGSYANLETVEDVFSVGLNRAVTVIAEKAKQAPGRGARGTPAALKTLGDHPDGGAITVRDGKYGPYVNWGKVNATLPKGKDPQAITVEEALALIAEKAGKAPASKTAKAKAKPKAAAAAAKSTKTAAKPKATKAKAPAKSKKG
(1817) DNA topoisomerase 1 [Sinorhizobium meliloti 1021]
1
MFQRMSMNVVVVESPSKAKTINKYLGPGYKVLASFGHVRDLPAKDGSVRPDEDFEMSWEVDGASAKRMKDIADAVKSSDGLILATDPDREGEAISWHVLDLLRKKKVIGDKPVKRVVFNAITKKAVLDAMAEPRDIDASLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVTEEYWNISALLKTPRGDEFEARLVSADGKRLPPKAIGNGEEANRLKSLLDGASYVVESVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIEAARQAIGSQFGERYLPEKPRFYSTKAKNAQEAHEAIRPTDFDRTPDQVRRFLDGDMLRLYDLVWKRGIASQMASAEIERTTAEIVADNAGKKAGLRATGSVIRFDGFIAAYTDMKEDGEQADDGDEDGRLPEINARENLAKQKINASQHFTEPPPRYSEATLIKKMEELGIGRPSTYAATVTTLIDRDYVEIDKRKLVPQAKGRLVTAFLESFFTRYVEYDFTASLEEKLDQISAGELNWKDVLRDFWKDFFSQIEDTKELRVTNVLDALNEELAPLVFPKREDGGDPRICQVCGTGKLSLKLGKYGAFVGCSNYPECNYTRQLSSDSNGDAEAAAANEPQSLGKDPHTGEEITLRNGRFGPYVQRGDGKEAKRASLPKGWTPAAIDHEKALALLSLPRDIGPHPESGKMISTGIGRYGPFVLHNGTYANLESVEDVFSIGLNRAISVLADKQSKGAGGGRASAAALKELGEHPDGGAITVRDGRFGPYVNWGKVNATLPRGKDPQSVTVEEALALIAEREAKGGVTKGKAAKGKPTGGKSAGTKSAKAASAGTAKAEKPKSAAKTKTKAAAKAKKD
(1560) DNA topoisomerase 1 [Brucella abortus A13334]
1
MGREFRLLYMNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEILRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGRDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEQITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(86) DNA topoisomerase 1 [Brucella ovis ATCC 25840]
1
MNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKTVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAITKSFSAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFAGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRVTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
(618) DNA topoisomerase 1 [Ruegeria pomeroyi DSS-3]
1
MPVVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPAKDGSVDPEHDFDMTWEVAADSRKHVKAIADALAEDNELILATDPDREGEAISWHLQEALTKRRSIKKGTAVSRVTFNAITKDAVTKAMQNPRQVDMPLVEAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVCLRLIVEREMEIEAFKPVEYWSVKALLETPRGQVYEARLVTLAGNKLDKMDISNATQAELAVQAITSRALSIQSVEAKPAARNPSAPFMTSTLQQEASRKFGMGARHCMSAAQRLYEAGHITYMRTDGIDMAPEAVMATRDAIADRFGAEYVPDSPRMYKNKAKNAQEAHECIRPTDMRKDAAALKLKDEDQRRLYDLIWKRTIACQMAAARLERTTVEIGSADGQVGLRATGQVVLFDGFLRVYEEGRDDVENDEDKRLPQISMGEKAVFAKTSLADQFARATGDTPLTEGAKIAKEAILSENEAVLALQHHTQPPPRYTEATLVKRMEELGIGRPSTYASVITTIQDREYVRKDKNRLIPEEKGRIVTIFLLNFFRQYVGYEFTANLEEQLDDVSAGSRDYKDLLGRFWRDFSAAISETSELRISEVLDKLDEALAPQLYPPREDGSDPRICPKCGTGQLHLKTSRTGGFVGCGNYPECRYTRPISGDADDSAERLLGEDGGDEIWLKAGRFGPYVQRGEISEENKKPPRASLPRGWSAEDLDLEKALVLLSLPRQIGQHPEGGMISSNFGRFGPYLMHQLPDEAKPIYANLKDPSDVFEIGMNRAVELLAEKRANPRGRGRAAAKPLKELGEHPEHGGAVNVLDGRYGAYIKWDKVNATLPKDVEAADVTMEMAVALIAEKSTKKGTKKKAAPRKKTTKKAAEE
(162) DNA topoisomerase 1 [Candidatus Pelagibacter ubique HTCC1062]
1
MNLVVVESPAKAKTINKYLGDDYIVLASYGHIRDLPSKNGSVDPENNFKMEWEVDSFSKKYLKEITDAAKISSKIILATDPDREGEAIAWHVKEYLNEKKLIKDKHIERVVFNEITKKAVIHGIENPRQIEPLLVDAYMARRALDYLVGFNISPILWTKLPGSKSAGRVQSVALKLITEREHEIELFDPEEFWTLSIQFNDSNKNSILASITQLNDKKIEKFSFKNKAEIDKAMKEVKSKNFNINDISSKVVNRNPSGPFTTSTLQQVSSGRLGFGASRTMQIAQKLYQGIEIDGETIGLITYMRTDGTNLSTDAIDTFRKYIKNEFGDEYVPDNAASYSGKKAKNAQEAHEAIRPTDIMRAPDTVKKYLSPDQHKLYDLIWSRALSSQMKPAQFDRNTITITSDDNGTICKASGSVIKFDGFLKVMKDTKKDDDEDILPEMNKGPVNIESLLDEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASIISVISTRGYAETINKRFHPTDRGKLISAFLEKLFSKYVDYNFTASLENQLDDITTGKEGWIKVLELFWKDFNQNVSDVKEKRTREVLDLLNDSLGSLIFERDTEGNINRQCKLCNGGSLSLKNSFRGGAFIGCSNYPDCKFTRPLSKAKAAAQSQLAEPKFIGKHENGNDMYLKNGRFGPYLQYEKIEEIKDEIIIETKKKKKTKKKKIEKEDNNLRNVSIPKGITLDSVDLDRAKFLCSLPKSLGINPENQRDIILNSGRFGPYLKCENKSARIENVEEIFSIGLNRAITLIAEAKPGRMSASIIKDLGEHPEDKKPVRVMKGQYGPYIKYKSLNATIPEEKDPLELNMEEALILIEKRKEYDKNKKVKKKKKK
(1569) DNA topoisomerase [Xenorhabdus bovienii SS-2004]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSITVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPVQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILLGEQTEPLWQAGLGRARADWLMGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMAALQKDDISFRVKWLPAPDDCDEEKRCIREDIAQSVVQRCQQAQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDASTLSRVWNDSQITAHHAIIPTRHTFDMTKLTADELKIYQLIRHYYLAQFLPVQETDVTDVTFTIGGQVFQAKGRVSVVTGWKTLFADEKQVQEQDDNTALPALKKEEICPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEALFNRQLLARKKKNLHATPLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRATLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVTGSRKTRRGNSPD
(143) DNA topoisomerase 3 [Xenorhabdus bovienii SS-2004]
10
MRLFIAEKPSLARAIADILPKPHRRGDGFIECGNNQFVTWCVGHLLEQAEPDTYDSRYARWVLSDLPIIPEKWRLKPRAAVAKQLNTIKSLLEKADEVIHAGDPDREGQLLVDEVLDFLNLRDDKKQNVQRCLINDLNPQAVIKAVERLRSNREFIPLCVSALARARADWLYGINMTRAYTLLGQNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFVPKDFFEVKAYIVTPNEEQFTALWQPSESCIDFQDEEGRLIHQPLAEHVVARITGQPAYVTAYQDKRESETAPLPFSLSSLQIEAAKRFGLSAQNVLDICQRLYETHKLITYPRSDCRYLPEEHFVGRHAVLNAISIHSSDLLPQDALESDKKNRCWDDKKVDAHHAIVPTARSSQVNLTENERQIYGLIARQYLMQFLPDAVFRKCTIELDIAGGKFIAKARFLAEAGWRTLLGNKERDEENEGTPLPVVAKGDELLCEKGEVVERQTQPPRPFSDATLLSAMTGIARFVQDKSLKKVLRATDGLGTEATRAGIIELLFKREFLYKKGRNIHATPAGRALIHVLPDMAVLPDMTAHWESKLTQISEKQFRYQDFMLPLQETLQQLIWQAKQYRNLKAFRDLPPVPMKGKKGKTKQVKKGKEKVNKTE
(1819) DNA topoisomerase 1 [Xenorhabdus bovienii SS-2004]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGAASQKSSNSSTDKNKKKKDEKTALVNRMGVDPYHGWEADYQILPGKEKVVAELKMLAEKADHIYLATDLDREGEAIAWHLREVIGGGEARFSRVVFNEITKNAITQAFDNPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEREREIKAFVPEEYWQLHADLMAKGDIDLHMEVTHEGGKPFKPINAQQTQAAVSLLEKARYKVLDREDRPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALDMVRGYINDQFGDKYLPKTANIYSNKENSQEAHEAIRPSSVDVMAEELKDMEADAQKLYQLIWRQFIACQMMPAKYDSTTLTIQAGNFELRAKGRTLRFDGWTKVMPALRKGDEDHTLPVVEVGTELDLKQLSPSQHFTKPSARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVRGENRRFYAEKMGEIVNDRLEENFNELMSYDFTARMEDQLDHVANNEANWKGVLDEFFTNFSEQLDVASKDPDEGGMRPNPMVSTSIDCPTCSRPMGIRTATTGVFLGCSGYTLSPKERCKQTINLIPENEILNILEGDEAETNALRARHRCKECGTAMDSYLIDNQRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGSEMHLKMGRFGKYMGCTSEECKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAASTFPKSRETRAPLVEELVKFKDRLPEKLCYLAKAPVADPEGHKTVVRFSRKTKQQYVSSEKNGKATGWAAFFVDGAWVVKEK
(1568) DNA topoisomerase [Xenorhabdus bovienii SS-2004]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSITVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPVQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILLGEQTEPLWQAGLGRARADWLMGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMAALQKDDISFRVKWLPAPDDCDEEKRCIREDIAQSVVQRCQQAQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDASTLSRVWNDSQITAHHAIIPTRHTFDMTKLTADELKIYQLIRHYYLAQFLPVQETDVTDVTFTIGGQVFQAKGRVSVVTGWKTLFADEKQVQEQDDNTALPALKKEEICPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEALFNRQLLARKKKNLHATPLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRATLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVTGSRKTRRGNSPD
(1793) DNA topoisomerase 3 [Haemophilus somnus 129PT]
10
MRLFIAEKPSLARAIADVLPKPHQRGQGFVKCGEQDYVTWCVGHLLEQAAPDVYNPMFKQWRLEHLPIIPQKWLLLPRQEVKSQLDIVLKLIHQADIIINAGDPDREGQLLVDEVFSYAKLPATKLAEIQRCLINDLNPSAVEKAIKKLQPNKNFIPLATSALARSRADWLYGINMTRAYTIRGRQSGYNGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVQAFIATKEKMPSTFTALWQPSKACEDYQDEEGRVLSNALAKNVVKRITAQPATVTEYIDKREKETAPLPYSLSALQIDAAKRYAMSAQEVLDVCQKLYETHKLITYPRSDCRYLPEEHFSARHTILRAISTHSILYKEIPDIVNTELKNRCWNDKKVEAHHAIIPTAKNKTVSLSQNEQQIYDLIARQYLMQFCQEAEYRKSKITLDIAGGTFIAQARNLQIAGWKQLWGKEDEDEQQEPLLPIVKKGDELFCEKGDVISKKTQPPKPFTDATLLSAMTGIARFVQNKELKKILRETDGLGTEATRAGIIELLFKRGFIYKKGRNIHSTETGRTLIQALPEIATQPDMTAHWEAQLDSISRRQGSYQQFMQTLSELLPELLGYFNFSALRKLGLQTKENKKADLKKNE
(600) DNA topoisomerase 1 [Haemophilus somnus 129PT]
9
MSKSLVIVESPAKAKTINKYLGNQYVVKSSVGHIRDLPTVGESSGEKAKPISTKGLSAEEKQRIKTEKEQNALVKRMGIDPYHNWEAKYQILPGKEKVVSELKSLAKKVDHIYLATDLDREGEAIAWHLREVIGGEDSRFSRVVFNEITKNAIKQAFEKPEQLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPQEYWEISVDSKNSQKRPIRLDVVQFQGKKFEPKNIEQTRSAVDFLQISDYFVKDLEIKPTTSKPKAPFITSTLQQSASTKLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSKDALEMVRNYIVQEFGQAYLLDKPNFYSSNENAQEAHEAIRPSDVKQLADSLEGMERDAVRLYDLIWRQFVACQMPAAKYDSTTVTVQSGDYELKSKGRVLRFDGWTKVLPQSNRNPEDQELPIVKVGEKLSLTKVEPQQYFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNQSFADLMSYDFTANMENILDQIADGKKNWKEELNQFFKDFSQQLTQAELDELDGGMKPNSLVATDIGCPTCNRQMAIRTASTGVFLGCSGYALPPKERCKTTINLIPEAELLNVLDESSETKALMERKRCSKCDTAMDSYLIDTTRKLHICGNNPNCDGYLVEQGEYKIKGYEGPIVECDKCGGEMHLKLGRFGKYMGCTNCDNTRKILKSGEVAPPKEDPVHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRESRPAKVAELAQYQDRLPEKLRYLADAPVKDPEGNEAIIRFSRKEKRQYVTSEKNGKTTKWSAYFVDGKWVENSK
(614) DNA topoisomerase [Haemophilus somnus 129PT]
4
MKLFLCEKPSQGRDIAKVLGATQKGEGYLSTADGTIVVTWARGHLVEHFSPEQYDPALKAWRLDTLPIIPSQWQVSPKPDAKKEYKTVMTLLKKARTVVISTDIDREGETIARELLDLAGYRGHIQRLWITALDEISVRKALSRLKTNEETLPLYYAGLARSRADWLIGMNFSRMFTLLAQQQGYQGPPLSVGRVQSPTLALVVNRDKEIAHFVPTYHYALMVQVCGTNAQSFEASLLVPEQYCDEEGRCLEIKVLQQAEQQIRQAGQVCVQNVETKREKESPPLLFALSDLQAECNRLYDLGTQQVLDIAQSLYEKHKATTYPRTDCGYLPEAQLLEVPQVINSLMQSDAKLQPLRVQLNLSQKSRAWNDKKITAHHGIIPTTQPVDIAKMNENEFKVYDLIRRRYLAQFLPHFEVDKTRVRLSCGEHQCIAKGQVIVSAGWKALFRASKEEQGEKQGLPILNSGQMLKVMNTEIKSLKTTPPAHYTEGTLLTAMVNVARFVTDERLKKQLRETEGLGTEATRASIMKTLYDRGYIKKKGKSIVATDAGVMLIDNLPTVLKDPGLTALWEQALNQIAENQMSLQEFMQKQEQFVLHLIQTCGHQGIKMGNIDIKKCPQCGKPLRKMKGKNGDFLGCTGYPKCKYIESGAKRKTSAGKVTPINLSQQFANLRQAVK
(1336) DNA topoisomerase 3 [Edwardsiella tarda EIB202]
10
MRLFIAEKPSLGRAIADVLPKPHRRADGYIQCGDGDVVTWCVGHLLEQAEPDAYDARYARWNLADLPIVPQKWQLRPKASSAKQLKVIEHLLRDAQQVVHAGDPDREGQLLVDEVLDFLALAPEKRRQVQRCLINDLNPQAVARALERLRDNHEFMPLCVSALARARADWLYGINMTRAYTLLGRNAGYNGVLSVGRVQTPVLGLVVRRDEEIAHFVAKDYYEVRAHIVTPAGERFWAQWQPSEACEPHQDEEGRLLNRALAEHVIARIQDKPARVTGYNDKRESEVAPLPFSLSALQIEAAKRFAMSAQQVLDTCQRLYETHKLLTYPRSDSRYLPEEHFAGRHAVMAAIAAHAPTLANLESVDVQRRNRCWDDSKVDAHHAIIPTARAGSVALNEDERNIYQLVARQYLMQFCPDAQYRKCVIDLEIEGGIFIAKARFLSQAGWRALLGAKERDDEDEGMPLPVVARDDLLHCERGELMARQTQPPRHFTDASLLSAMTGIARFVQDKSLKKILRATDGLGTEATRAGIIELLFRRGFLHKKGRYIHASPAGSALIHCLPEMAGRPDMTAHWEATLTKISERGCRYQDFMHPLVETLQQLIHQARTAVNPRAFRDLPPAESARPRRAKGASTASNKRKKA
(1290) DNA topoisomerase 1 [Edwardsiella tarda EIB202]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKGAASADDKAKTKAKKNERDALVNRMGVDPYHGWQAHYEVLPGKEKVVSELKSLAEKADHIYLATDLDREGEAIAWHLREVIGGDDSRYSRVVFNEITKNAIQQAFSQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEREREIKAFVPEEYWELRADLAVGAEVSFQAQVTHCNDKPFKPVNAAQSQAAVAALEHARFAVREREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALNMVRAYIGDNFGAEYLPADANVYASKDNSQEAHEAIRPSDVNVLADDLKGMEADALKLYQLIWRQFVACQMTAAKYDASTITVQAADYTLKARGRTLRFDGWTRVLPQLRKGDEDRALPAVESGRALDLLQLQPSQHFTKPPARFSEASLVRELEKRGIGRPSTYAAIISTIQDRGYVRTDNRRFYAEKMGEIVTDRLEENFRELMSYDFTAHMEDGLDRVASAQADWKVMLDGFFSDFSQQLEVAEKPPEEGGMRPNPMVLTSIACPTCERQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEAEVLNVLEGDDAETNALRAKRRCPKCGTAMDSYLIDNHRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGAEMHLKMGRFGKYMGCTNEACKNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAEAPQQDEQGNATLVRFSRKTKQQYVSSEKEGKATGWTAFFIDGKWVVSEKK
(1096) DNA topoisomerase [Gallionella capsiferriformans ES-2]
3
MKQAVKVTTNHSARNTFYLCEKPSQARTLAKVLGAEKGRDQMHFAEGVVIGHAYGHMLNLAKPETYIGTGPWCLDNLPILPKTWLWQVKDEHREHLDNLGKYLSQADLVVLATDPDEEGEVIGRQILQTHNYSGEALRLWMSALETESLKKSLQNLRPLSETDHFYQAGRVRHEMDWLFGMNLSRAFSVLLKSKANIGRVKTRLLNEIVTNDQQAENVIQDGYETAYVMLGDTLLELIQADQPCDHIVNFKKLAGAQCGIYRNDKSCNYTDEMGVPLVTPRPLPYTLTALLADSADIGIPLDEGYKAVQKLYESGAISYPRTNSTKLPGTSSDDFAVHHAIVAMRDDLPAGMTEEATRIFELIRLNELYQRNQLITIDRTQTIEIGGEYFASREEWKTISFDSPDRALLKNQNILANQKKLAIYKTGDEFPVKVRLTRENYGKPTYFTESSLLRMMAEKGIGTESTRVAAITNLIKEKLIDVTPQTDHEGVPSTQARTIRSTKLGRDLISRLPEVVTGQEMEAQLQEALKDMRVGQSDESTHLKHTGAWLTKTIREAA
(394) DNA topoisomerase [Gallionella capsiferriformans ES-2]
3
MKQTVKVTTNPAARNTFYLCEKPSQARTLAKVLGAEKGRDQMHFAEGVVIGHAYGHMLNLAKPETYIGTGPWCLDNLPILPKTWVWQVKDEHREHFDNLGKYLSQADLVVLATDPDEEGEVIGRQILQAHNYSGQVLRLWMSALETESLKKSLQNLRPLSETDHFYQAGRVRHEMDWLFGMNLSRAFSVLLKSKANIGRVKTRLLNEIVTNDQQAENVIQDGYETAYVMLGDTLLELIQADQPCDHIVNFKKLAGAQCGIYRNDKSCNYTDEMGVPLVTPRPLPYTLTALLADSADIGIPLDEGYKAVQKLYESGAISYPRTNSTKLPGTSSDDFAVHHAIVTMRDDLPTGMTEEATRIFELIRLNELYQRNQLITIDRTQTIEIGGEYFSSREEWKTISFDSPDRALLKNQNILANQKKLAIYKTGDEFPVKVRLTRENYGKPTYFTESSLLRMMAEKGIGTESTRVAAITNLIKEKLIDVTPQTDHEGVPCTQARTLRSTTLGRNLISRLPEVVTGQEMEAQLQQALKAMRDGHSDESAHLMRTATWLTQTIHEAA
(1726) DNA topoisomerase [Gallionella capsiferriformans ES-2]
3
MKQAVKVTTNHSARNTFYLCEKPSQARTLAKVLGAEKGRDQMHFAEGVVIGHAYGHMLNLAKPETYIGTGPWCLDNLPILPKTWLWQVKDEHREHFDNLGKYLSQADLVVLATDPDEEGEVIGRQILQAHNYSGEVLRLWMSALETESLKKSLQNLRPLSETDHFYQAGRVRHEMDWLFGMNLSRAFSVLLKSKANIGRVKTRLLNEIVTNDQQAENVIQDGYETAYVMLGDTLLELIQADQPCDHIVNFKKLAGAQCGIYRNDKSCNYTDEMGVPLVTPRPLPYTLTALLADSADIGIPLDEGYKAVQKLYESGAISYPRTNSTKLPGTSSDDFAVHHAIVTMRDDLPTGMTEEATRIFELIRLNELYQRNQLITIDRTQTIEIGGEYFSSREEWKTISFDSPDRALLKNQNILANQKKLAIYKTGDEFPVTVRLTRENYGKPTYFTESSLLRMMAEKGIGTESTRVAAITNLIKEKLIDVTPQTDHEGLPSTQARTLRSTKLGRDLIRKLPEVVTGQEMEAQLQQALKEMRGGQSDESTHLMRTDAWLTQTIREAV
(144) DNA topoisomerase 1 [Gallionella capsiferriformans ES-2]
1
MAINLLIVESPAKAKTLKKYLGNDYEVLASYGHVRDLVPKTGAVDTENGFAMNYETIARNSKHMDAIAKAAASAENILLAPDPDREGEAIAWHIAELLKAKRGFKGKNMKRVVFYEITQSAVQAAVANPREIAMPLVNAQQARRALDYLVGFNLSPLLWRKIRPGLSAGRVQSPALRLIVERELQIEAFKTQEYWSVHLDTQKNHQSFSARLIQYQGKKLEQLSIASQSEYDAIYAKLNDAKLPPKVVKVEKKAKQRYAAAPFTTSTLQQEAVRKLGMSAERTMRTAQSLYEGVDIGGQTVGLISYMRTDSVSLANEAVAEIRNYIGDHFSSEYLPGTPPTYKSKTKNAQESHEAIRPTSIVRTPDSLQDRLTVDQARLYEMIWKRTLACQMTAARYDTVSADIRLGGDDTLFRANGQVLVFPGFISVYMEDVDDAEEEQGSRLPPLVEGDILPVDKLFGEQHFTQPPPRFTEASLVKSLEEYGIGRPSTYATIISTLQTREYAILDKKRFMPTDVGRVVTRFLTDHFTRYVDYNFTASLEDELDEVSDGKRDWIGVMDEFWKGFSALIKEKTNIERPQELLDEACPECGKPLAKKLSRYGSFISCTNYPECKYKRSVGGETQEEVRVELGVHPESAQAVLLLRGPYGHYVQLGEVIEGEKAKPKRVSWPKEMAVDQADLESALKLLSLPKDLGLHPETNKKVIVNIGRFGPYIGHDGKFKSIPRTDSIFDVTLDRAVELLAQAKDGNTVLRTLGDHPVDKTTVEICSGRYGPYARHGKINATLPKDVSPDEITLEQALELIAAKAAKGDTKPARKSAAKPKATAKPKAAAKPKAAAKPKAAPKAEAKPKAAAKPKAAPKAAAKPKAAAKKA
(1754) DNA topoisomerase 1 [Methylovorus glucosetrophus SIP3-4]
1
MSKLLIVESPSKAKTLKKYLGSDFEVLASYGHVRDLIPKNGAVDPENDYAMKYEVIDRNSKHVDAIAKAVRASDAIYLATDPDREGEAISWHIAEILKDKKLIKDKLIKRVVFHEITKTAVQNAIASPRDISMPLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWTIHLESKKHQHLFDARLVQLDGSKVEQFTVTNETQQAEIVGKLLLASAGKTTVSRVEKKQKNRSPAAPFTTSTLQQEAVRKLGFTTSRAMRIAQQLYEGIDVGNGTVGLITYMRTDSFSMAAEAVMQIRDYIKRNFEPDYLPKSPIMYKTKAKNAQEAHEAIRPTDITRTPQSLKNYLTPEQFRLYEMIWKRALACQMAPAKFDAVSVDLAVGSDANLFRATGQTMIFPGFIAVYMEGQDDAEEEAEAKLPHLETGEVLDVNKIFGDQHFTEPPPRYSEASLVKVLEEYGIGRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTRYVDYGFTANLENELDDIAEGEREWVPVLDDFWQGFNKQLLEKANIDRAEITQEDIGEACPKCGKPLHSRLGRFGKFIGCSGYPECDYIRNTGSNAAASSEPVVMGHDAASDKDILLLNGPYGPYLQLGLPEEGSKKKPKRVSIPKEIPLANVDLEVAMKLIALPRDLGQHPETGKKIVANIGRFGPYVNHDGKFKSIPRSDSVFDIDLPRAVELLAQAKSGPAPLKDLGKHPTEDGNIEVYAGRYGPYVQHGKLRATLPSSEAPEELTMEEALALLAAKAAKEAPAKKPAAKKKTTAAKKPAAKPAAKKTTATKKPATRAKKTAVTES
(1424) DNA topoisomerase 1 [Methylotenera mobilis JLW8]
1
MSKLLIVESPSKAKTLKKYLGSDFEVLASYGHVRDLIPKNGAVDTENQFAMKYDIIERNSKHVDAIAKAVKNADSIYLATDPDREGEAISWHIAEILKSKKLLKNKLMKRVVFHEITKGAVEHAIAEPRDISMPMVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLDALKHQHGFKAKLVQLNNQKVEQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTLQQEAVRKLGFTTSRAMRVAQQLYEGVDVGGGTVGLITYMRTDSFSLATEAVMQIRDYVKKNFDTEYLPKSPVMYKTKSKSAQEAHEAIRPTDISRTPTSVRQYLNDEQFKLYEMIWKRALACQMAPAKFDAVSVDLSVGSDANLFRATGQTLVFPGFIAVYMEGSDDEEEEAESKLPNLETGEILTVEKIYGEQHFTEPPPRYSEASLVKVLEEYGIGRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTKYVDYDFTANLENALDSVAEGERDWVPLMDEFWQDFNQQIHNKADVERPGNELIDEACPKCGKPLQKQLSRFGSFIGCTGYNDTPKCDYKRSIDGTANAGTDPVSIGVDAATSKEIYLMNGPYGPYLQVGMAVEGEKKKPKRVSIPKEIALADVNLETANMLLSLPRDLGLHPETNKKIIANIGRFGPYINHDAKFKSIPKNLSVFSIDLDGAVALLAQAHTGPAPLCSLGSHPTEDGQIEVFAGRYGPYVQHGKLRATLPKSIEPESLTMEEALELLSAKAAKDAPAKKAPAKKAAAKKTVAASEDKPAAKKAAPKKATTKKAAPKKATAKKSE
(1884) DNA topoisomerase 1 [Anaplasma marginale str. St. Maries]
1
MGVVIVESPSKAKTISKYLGGKYKVVASFGHVRDFPAKSGSVDPDDDFRMIYEIIPKSEKYIDKIVKTVSSEKSGIYLATDPDREGEAIAWHIVEVLRERSAIGEDVAVNRMVFNEVTKRAVNAAINDCRSINMDLVHAQQARRVLDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICEREHEIEQFDSKEYWDIEVLLKNNSGEKLTATLKHYNGEKLDKFAIPDADSANAIAEHVRNGTYHVASVEAKQTKRNPYPPFITSSLQQEASTKLGFSAKNTMMVAQKLYEGVDIGGETVGLITYMRTDGFYISTEAISYIRDTIKMQFGDKYLTKSPRQYVKKVKNAQEAHEAIRPTDITMTPDSLAKYLSDDQLKLYDLIWRRTMASQMESAVIDQVIVDIQSKDGSVVLHAVGSSLGFDGYQKVYGTDDDDKRKMLPQLKVGEACNLVEVSPNQHFTQPPPRYSEASLVKKMEEIGIGRPSTYAAIISVLQERGYTQLEQKKFVPSERGRIVNAFLTNFFSRYVEYDFTANLEEELDLISNGNMAWKEVLRRFWHKFISDVSTVKGIEVSEILKSITKDLEGYAFSSSSGEVVDRSCPGCGEGELMLNIGKYKAFLGCNRYPECKYTRGIGGESGVCRDEFPKVLGLDDATQEEIVLKNGPYGEYLQLGDNAQGKRVAVPQGIQEITLDVAKKLLSLPIVLGNYPDTAQDIKLGTGRFGPYVLYGGTYFSVKGREDFWNLTLEEAVDVINSQAQKKSRLLGLHDNGKEIYVCKGRYGFYLKCGDKNVAIKGKSDDITLEEAVSLLNQKA
(1297) DNA topoisomerase 1 [Rickettsia canadensis str. McKiel]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAIKYDISDKASKYVDAIVKDAQKADAVYLATDPDREGESISWHVAEVIKEKNKVKAADFFKRVAFNEITQKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKAEEYWDISLKMQNSNNELFTAKLTHINNQKLERFSITNKKDAKDLTKKLKSQNFHIDQIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVADIRKLIDKNYGDKYLPSSPRIYKSTVKNAQEAHEAIRPTNITYTPDSLKEKLAKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVYRESVDDEAEEENKMLPLLKENEQLNTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYATILSVLQDRKYVSLKKKRFMPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKSALSNFWSGFNHNIKSVNEQKITEIISYVQKALDYHLFGENQESKACPSCKTGELSLKLGKFGAFLACNNYPKCTFRKSIVSGNNNNENEDKLSTTPNEENKVLGTDKDGIEIYLKKGPYGPYIQRGEHEGTVKLKRSPVPASLNQSDITLDIALKLLSLPLKIGTHKDTHEEIMIGYGKFGPYIKYIGKFISIPKKYDFLNLSLDEAIQLIEDNKTKLEKKQA
(1053) DNA topoisomerase 1 [Rickettsia prowazekii str. Madrid E]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDKNFLMEYDISDKAGKYVDAIVKEARKAEVVYLATDPDREGESISWHVAEVIKEKNKVESDDFFKRVAFNEITKKAIMNAVANPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICDREDEIERFKSEEYWDISLKMQNSNNDLFTAKLTHVNDQKLKKFSIINEKEAKDLTQKLKLQKFYVEKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGNQYLPIKPRIYQSKVKNAQEAHEAIRPTNITYTPDSLKQKLEKDYYKLYELIWHRTIACQMENVIMDLVIANLASENKEYLAKANGSIIAFDGFYKVYRESLDDEDEEDNKMLPPLKEQEHIKTKEVIPNKHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKTALNNFWRGFNHNIESVNEQKITEIINYLQKALDYHLFGEDKESKVCPSCKTGQLSLKLGKFGAFLACSNYPECTFKKSIVSGNDNNEDEGDPSTILNDNKILGTDQDGVEIYLKKGPYGPYIQLGEQCGKVKPKRTPVPANLKQSEITLEIALKLLNLPLKIGIHKDSGEEIIIGYSKFGPYIKYMCKFISVPKKYDFLNLSLNDAMKLIQNNKAKLEKKYG
(772) DNA topoisomerase 3 [Klebsiella oxytoca KCTC 1686]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDARYARWNLLDLPIVPEKWQLQPKPSVTKQLNVIKRLLGDAQEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPKDERFVATWVPSEACEPYQDEEGRLLHRSLAEHVVKRIEGQPATVTAYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIGVHAADLLPQPVVDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLSDNEEKVYGLIARQYLMQFCPDAVFRKCQIDLDIANGKFVAKARFLAEAGWRTLLGNKERDEENDGMPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESILTQISEKQCRYQDFMQPLVGTLFQLIDQARSTPVRRFRGIVAPGDGKKSFSKGKGRAKAKDKKSAAGPAAESPQ
(60) DNA topoisomerase 1 [Klebsiella oxytoca KCTC 1686]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERGALVNRMGVDPWHDWNAHYEILPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVTHNGDKPFRPVNRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPESANQYASKENSQEAHEAIRPSDVNVLAETLKDMESDAQKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPMVNKGDSLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKQVLDSFFGDFTSQLQTAEKDPEEGGMQPNPMVLTTIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLAEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVASEKDGKATGWSAFYIDGKWTEAKK
(1188) DNA topoisomerase 3 [Erwinia billingiae Eb661]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGQDQMVTWCVGHLLEQAQPDSYNSRFARWSLADLPIVPEKWQLKPRPSVAKQLNVIKGLLEQATEVVHAGDPDREGQLLVDEVLDYLSLPPEKRANVQRCLINDLNPSAVERAVSRLRENKEFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGLLSVGRVQTPVLGLVVRRDEEIENFIAKDFFEVKAHIVTPKDERFVALWQPSDSCEPYQDEEGRLLHRPLADHVLARIGGQPANVTSYNDKRENDTAPLPFSLSSLQIEAGKRFGMSAQTVLDTCQKLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINAHQPDLTPPADFDSDRRNRCWDDKKVDAHHAIVPTARSSQVRLTENESTIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFVAKARFLAEAGWRSLLGSKERDEENDGTPLPVVAKGDELLCERGEVVEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRAFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMLPLVETLHNLIYQARQQPAAHAFRGLPAAEPKKPRRKATKAKETE
(686) DNA topoisomerase 1 [Erwinia billingiae Eb661]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTVKKSADSTTSKPAKKVKKDEKAALVSRMGVDPFHGWEADYQILPGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFTPEEYWELHADLNTPKGTGLPMEVTHQHDKPFRPVNGEQTHAAVSLLEKARYVVADREDKPTSSKPGAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVSMVRGYIETEFGAKYLPKAANVYSSKENSQEAHEAIRPSDVAIQSEQLKDMEADAQKLYQLIWRQFVACQMMPAQYDSTTLTVAAGDFKLKAKGRTLRFDGWTAVMPALRKGDEDRTLPPVEVGEELKLQQLKPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEANFRELMNYDFTAHMEDNLDKVANNEAQWKGVLDQFFADFSQQLEKADKDPEEGGMQPNQMILTSIDCPTCNRKMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARHRCQKCGTAMDSYLIDNQRKLHVCGNNPGCDGYEIEQGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGDVAPPKEDPVPLPELTCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFRDRLPEKLSYLADAPVSDEEGNKAVVRFSRKTKQQYVSTEKDGKATGWSAFYVDGKWEVASKATATKAAPVKAAANKATATKATAKKAAKK
(935) DNA topoisomerase 3 [Serratia sp. AS12]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGNNDVVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNAIKKLLHDADEVVHAGDPDREGQLLVDEVLDYLALTPEKRHSVRRCLINDLNPQAVERAIDRLRDNRDFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVPKDFFEVKAHIVTPKEERFVALWQPSDSCEPYQDEEGRLLHRPLAEHVLKRIEGQPALVTSYNDKRESDTAPLPFSLSTLQIEASKRFNLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISAHQPDLYPQPVIDSDRRNRCWDDKKVDAHHAIIPTARASKVSLSQDELNVYGLVARQYLMQFCPDAMFRKCVIELDIAGGKFVAKARFLAEAGWRTLLGSKERDEENEGSPLPVVAKDDELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIELLFKRAFLYKKGRYIHSSETGRALIHSLPDIAARPDMTANWEATLTQISEKSCRYQDFMQPLVGTLQELIYQAKQSRASMAFRGLPPSPSAGAKKRKKSAGKAREKSE
(1639) DNA topoisomerase 1 [Serratia sp. AS12]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTEDKAKKKVKKDEKTALVNRMGVDPYHGWKADYEILPGKEKVVAELKSLAENADHIYLATDLDREGEAIAWHLREVIGGDEKRFSRVVFNEITKNAIQQAFKQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKNDTALQMEVTHAHDKPFKPVNREQTHAALKLLEKARYTVLDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGDNFGDKYLPKAPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLSVKAGDYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPYVEVGSDLELQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEENFRELMNYDFTARMEDGLDQVANNHAEWKAVLDEFFAEFSEQLETAEKDPEDGGMRPNQMVMTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPETEVLNILEGDDAETNALRARHRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEEGEFRLKGYDGPVVECDKCGSEMHLKMGRFGKYMGCTNETCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADGEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(40) DNA topoisomerase [Serratia sp. AS12]
4
MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPWRESVLPIVPTQWKMAIKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHFTGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAREQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRGTLQKGGIAFPANWVPAANYCDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMSANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRAFVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEATFNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELKTLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYLEKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGHLVEKGKTQAVKFTAPPSPPCPTCSGSMRRRAGKKGGGAFWGCSNYPTCQGVINIDAKGGRKAKRYKAKSPTKNKATGSE
(866) DNA topoisomerase 1 [Francisella cf. tularensis subsp. novicida 3523]
1
MAKNLVIVESPAKTKTIKKYLGNEFEILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKAAKDAQNIYLATDPDREGEAISWHVQEVLKSARLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVDAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLIEFNNNKVEQFTFTTAEDAENAKVDILKDANGFLIVDGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIQAKYDKDMLPAKPRVFEKKSQNAQEAHEAIRVTAANRTPESIKQFLTSDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHKFRVTGTVIVDAGFLKIYNVEKDEDDKDSDDEQTLPKFEKGERITLNDVITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQREYVEVDKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLSVLNNFWHPFIERINKISEDVSRKDVVQEELDEDCPECGSKLSLRLGKNGRFIGCTNYPTCKYTRPVDSDPKEVAKEEPVVVEDRKCPKCSSDLHIKQGRYGKFIGCSNYPECKHMEPLEKPKDTGVVCPKCNKNHIVEKKSRKGKVFYACAGFPKCKNAYWYPPIKEECPKCHSPILLHKTTKKDGEQKACPNSECDYAVPFEAK
(640) DNA topoisomerase 1 [Campylobacter fetus subsp. fetus 82-40]
1
MSKLIIVESPAKAKTIKNFLGSEYKVIASKGHIRDLPKSSFGIKIEDDKFTPEYRVSSDHSAIVKEIKDLAKNADTIYLATDEDREGEAIAYHIAAAIGKKPEMLPRIVFHEITKSAIQNALENPRSLNMDSVNAQQARRLLDRIVGYKLSPLLNSKIQRGLSAGRVQSSALKILVDREREIRNFKPIEYFSIDTKFKKDLEAELVEFEGSKIEKLTITNKDRAKFIVDKIKDESFSVANVESKERKTSPQPPFMTSTLQQSASNRLGFSPKKTMMLAQNLYEGVQTNNGFMGAITYMRTDSLNLAKEAISAARDLIKEQFGDKYLPKSANFYTTKNKGAQEAHEAIRPTNLSFTPTEAAKFLEKDLLKLYTLIYNRFLACQMSASVSETQNIFINSKSSIFKISGRKLTFDGFYRVYGDLDKDRILPNLNVGDKMELESLSSQSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISLLTSRDYVKVDKKQLIPNEIAFNITSMLEEHFNDIVDSDFTSKMEEKLDDIAENKADWQEVLSKFYHPFMQKIDDGKKNIKSQKVTEPIGEKCPECGGELVKRKGRFGEFIACLNFPKCKYSRNLKNEAKIEKKEPQKIGVACPQCGGDIVERFSKKGKFFGCANYPKCNFISKYQPTDQKCPQCGEMMVYKELKKGNFYECSACKFKKEGNNNE
(555) DNA topoisomerase III [Thiomonas intermedia K12]
7
MRLIIAEKPSVAQAIADVIGGVRRGDGYIDCPQAKTRVTWCFGHLLEQARPEDYVNGGKVLASHLPVIPTAWKLAPRDGGAGKQIKAIRDLLKDATEVVNAGDADREGQLLVDEVLLFLNWKGKTTRLWLSSLDDESVRRALVTVKSNDALRPLYESALARQRADWLMGMNASIALSRNLQACGVQGAWSVGRVQTPTLALLVDRQRDIQNFKPRDHYQVQATLDGDIRALWQIPEDLQTDDGLLLDKSAAETCAQAVQGQRATVAAFTRKAGERQAPMPYALSTLQKTASSRLGLSAKDTLAAAQELYEAKLATYPRSDCPWLPVEMHAAAAQIIRALGAAEMAGIDPERRHPAWNTAKVEAHHGIIPTGRGLAEVSGLSENAKKIYGLLRESYLRLFMPPETFETREALFTFPGAERFKASARIVQESGWTQLGQADNSAEDDETGQVARLPILTEGQQLACESAQVLAKRTSPPKPYTDGTLIAAMTGVHKLVTDPKLKARLKETSGLGTEATRASMIEVLIAREYAERKKKEIHPTERGVQLIDMLRKVAPDLADPGTTALQEDALAAIASARSTFDEFMTAQIDAVRESTQKLLGGQLGATPAILHACPACGGGRCAQRTSKAGATYHRCLDCDAAFGDDGGKPGKRFEDKHQSEGAAAKAPASGPKCLSCKKPTFKNETKTGKPYYRCGGCKGAWWPDRKDEGKLGTKWEERAGARA
(1850) DNA topoisomerase [Thiomonas intermedia K12]
5
MSKTLVIAEKPSVAQDIVRALTPQSGKFDKHDEYFENEQYVVTSAVGHLVEIKAPDDFEVKRGKWSFAHLPVIPPHFDLNPIEKTKSRLAAVVKQLKRKDVTALVNACDAGREGELIFRLILQYAEGKKALDKPVKRLWLQSMTPQAIREGFERLRGDADMRPLADAARSRSEADWLVGINGTRAMTAFNSKDGGFFLTPVGRVQTPTLSIVVTREEQIRKHIAREYFEVHAQFGAPAGAYAGKWFDPAFKRGEDADARADRLWDKARAEAIVAACNGQPATVRDESKPSTQLSPALFDLTSLQREANGRFGFSAKTTLGLAQALYEKHKALTYPRTDSRHLPEDYLAVARQTAQALAEAGGAIAPHARRALEADYIRPSKRVFDNAKVSDHFAIIPTTQTPGALTEAEAKIYDLVARRFLAVFFPAAESLVTTRISTVGAHQFKTEGKILVKPGWLEIYGKEEQGADDNLPAVKEGDAVQAETVELKTLKTRPPARYSEATLLGAMENAGKMVEDEELAEAMSGKGLGTPATRAATIEGLLAEAYMVREGRELIPTAKAFQLMTLLRGLQVEELTKPELTGGWEHKLAQMERGQLSREAFMRDIAGMTETIVRRAKEFDRDTVPGDYATLQTPCPNCGGVVKENYHRYACTQCDFSIGKHPGGRSFELAEVEQLLRDKHLGPLTGFRSKMGRPFAAELKLAQEDGKGQWKLEFDFGDSAPGSDGGEAPDFSSQQPLGACPKCGSAVYEAGSSYVCEKSVGPAPSCDFRSGKIILQQPIEPEQMRKLLETGRTDLLDGFVSARTKRKFKAFLVKQTGGKIGFEFEPRPAKAPAKKAAAKKATA
(1673) DNA topoisomerase [Thiomonas arsenitoxydans]
7
MRLIIAEKPSVAQAIAGVIGGAKRSDGFIDCPQAKTRVTWCFGHLLEQAKPEDYVDGGKVLASHLPVIPTTWKLSPRDGGAGNQVKVIRDLLKDATEMVNAGDADREGQLLVDEVLLFLNWKGKTSRLWLSSLDDASVRKALSSIKDNAAMRPVYESALARQRADWLMGMNCSIALSRNLQACGMPGAWSIGRVQTPTLALLVDRQREIGHFKPRDFYQVVALLDGGIRAAWQTRDDLVDEDGRLLDKARADATSHQITGKAARVTRYTRKTGERSAPLPYTLGGLQKAASSRLGLSAKDTLAAAQELYEAKVTTYPRTDCPYLPIEMHGGAAGILKAIGGTDIAGIDPERKHAAWNTAKVEAHHGLIPTGQSPDAAGLSADAKRVFGLIRESYIRLFIPPEKFETREAIFDIDGLTFRAAARVVLDPGWTKLGGRDEDEGQEQGEAQGALPDLREGEARTCERGEVVAKRTTPPKPYTDGTLIAAMTGVHKLVTDPKLKARLKETSGLGTEATRASMIETLIAREYAERSKKEIHPTDRGAQLIDMLRKVAPEVADPGYTALQEDALADIAAGRAPLAAFMRAQVDATREFSRTLLDGRLTDQSIAMHACPACGGARCAKLTSKAGNAYHRCMDCQAAFGDAGGKPGKRFEDRPQGDGAQKTSSAAATGPKCPICKKPTFKNETKTGKAYYRCGGCRVAWWPERKDESKLGTKWEAMK
(911) DNA topoisomerase [Thiomonas arsenitoxydans]
5
MSKTLVIAEKPSVAQDIVRALTPQSGKFDKHDEYFENEQYVVTSAVGHLVEIKAPDDFEVKRGKWSFAHLPVIPPHFDLNPIEKTKSRLAAVVKQLKRKDVTALVNACDAGREGELIFRLILQYAEGKKALDKPVKRLWLQSMTPQAIREGFERLRGDADMRPLADAARSRSEADWLVGINGTRAMTAFNSKDGGFFLTPVGRVQTPTLSIVVTREEQIRKHIAREYFEVHAQFGAPAGAYAGKWFDPAFKRGEDADARADRLWDKTRAEAIVAACNGQPATVRDESKPSTQLSPALFDLTSLQREANGRFGFSAKTTLGLAQALYEKHKALTYPRTDSRHLPEDYLAVARQTAQALAEAGGAIAPHARRALEADYIRPSKRVFDNAKVSDHFAIIPTTQTPGALTEAEAKIYDLVARRFLAVFFPAAESLVTTRISTVGAHQFKTEGKILVKPGWLEIYGKEEQGADDNLPAVKEGDAVQAETVELKALKTRPPARYSEATLLGAMENAGKMVEDEELAEAMSGKGLGTPATRAATIEGLLAEAYMVREGRELIPSAKAFQLMTLLRGLQVEELTKPELTGGWEHKLAQMERGQLSREAFMRDIAGMTETIVRRAKEFDRDTVPGDYATLQTPCPNCGGVVKENYHRYACTQCDFSIGKHPGGRSFELAEVEQLLRDKHLGPLTGFRSKMGRPFAAELKLAQEDGKGQWKLEFDFGDSAPGSDGGEAPDFSSQQPLGACPKCGSAVYEAGSSYVCEKSVGPAPSCDFRSGKIILQQPIEPEQMRKLLQTGRTDLLDGFVSARTKRKFKAFLVKQTGGKIGFEFEPRPAKAPAKKAAAKKATA
(99) DNA topoisomerase [Burkholderia phymatum STM815]
5
MGTKPGWENPRYRPESTNLFSVMSKALIIAEKPSVANDIARALGGFTKHDEYFESDDFVLSSAVGHLLEIAAPEEYEVKRGKWSFANLPVIPPHFDLNPIAKSESRLKVLNKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIREGFAQLRTDAEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCASGFYEGRWYDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRGQTGNVTEESKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLETVKHTMEMLKESNNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKALSEPEQKLYDLVVKRFLAVFFPAAEYRVTTRITEVVGHHFKTEGKVLVEPGWLQVYGRETGGEDANLVPVQKDEKVKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLDVKELTAPELTGEWEYKLSQMERGKLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACTKCEFSMSKIPGGRQFEIEEVEELLQKKQIGPLSGFRSKMGRPFSAILKLSFDDETKNFKLEFDFGQDQGGEDGEAPDFSEQQPVGACPKCSGKVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLENGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKEPKEGAAKTAAAKAAAKAAPESATGEAANEATPVKKAATKTAAAKKAPAKKAAAKTSAAKSAARKTGS
(370) DNA topoisomerase [Burkholderia glumae BGR1]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDLLINACDAGREGELIFRLIAQHAKAKQPVRRLWLQSMTPAAIRDGFAKLRSDEDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWYDPKFKRDEHDPEKRDSRLWSLPAAETIVAACRGQIGVVSEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKGWVKPNKRIFDNTKISDHFAIIPTLQAPKALSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDKIAAHALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVRELTAPELTGEWEYKLSQMERGNLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEDGEAPDFSTQEPVGACPKCQARVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLSDGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKPGAAAKKTAARAAANEDGAARETEDGAAPAGKTAAKKAPAAKKAPAAKKAPAAKKTPARKTGS
(412) DNA topoisomerase [Burkholderia glumae BGR1]
3
MRLWIFEKPSMAKAVIPHLPKPHTRHEGYYETGDGYVSWLAGHVMEQVQPGDYDERWGKFPWAFEDLPIIPKDWKLKVSEDKKGQVKIIETLLKKCTSIVNGGDADREGQLLVDEVLLHFGNTKPVARIHLSAMDPTSVKKAIASLEDNATFRPLYEAGLGRQRADWLVGMNMSRAYTILAKKQNYPGVLSVGRVQSPTLALVVKRDREIDGFVPKDFWTVEAQFADPGQSALPFWSRWLPPGLSLESAEKQADVDAKGEADEDEEGDEIEGEGGTVTGQRPAWLDEQNRIINKAVADQIAANVQAAGQGTVTRYVNKPAEEQPPLPFELTGLQTALNGKYGYSAKEVLDTCQELYLQGHTTYPRSDCPYLPVSQHAEAPDVLDAIARGAPHLASLAANANVTIRSRVWNDSKVTEHHALIPTRQAPDWSTMTEIKRRTYEMIAQRYLAQLYPNCQVDKAKVEVSIAGERFAASGRVVKDPGWRVVFQGEAQATDAKKAKDATPTLPVLTEQGPVNRLAVRVDAKRTTPPPRYTEGSLLTAMKHVHRTVTDPVERKKLKALDGIGRSATRAGIIEMIIKRGFVEVKGKQLVATVVGKILVDALPAKLTDPGMTARWEALLDAIAKKQIPLHAFMAKQEEAIGELVAAARVSTLPTIPPDAMPARKPYTGSSTPRPAPDGAKKCPKCKKGYLVPRTVKNGPKAGQTFHGCNNYPECKHSVWPK
(1240) DNA topoisomerase [Burkholderia ambifaria AMMD]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDTDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAAFACANGFYEGKWYDPKFKRDEFDPERRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYISTVQSTLEMLKESHNYLPHAKRVLDQGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEFRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIAEVEELLQQKTIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEEGEAPDFSEQEPVGACPKCNGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITRDQMAKLLADGRTDLMPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDAETVTEGADEKPAPARKTAARKTTARKTGS
(1213) DNA topoisomerase [Burkholderia vietnamiensis G4]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDNDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFACAAGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQIGTVSEESKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLATVQSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVQVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIAEVEELLREKTIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGDEGEAPDFSAQEPVGACPKCNGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMAKLLADGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDAETVTEGADEKPAPARKTAARKTTARKTGS
(1414) DNA topoisomerase III [Burkholderia vietnamiensis G4]
3
MKRLFIAEKPAMARDIAKHMGGRMTKKVGYVEVDMGGGVVNIVASCIGHLLKQAEPADYVKDLEFPGTFADLPILPDQWKLQIAEKKSAQVTLLRRLLRECDEVVNAGDPGREGQLIIDELLEFCGNRKPVKRILLNSLDSATVKRELANLQDNTRFKPIYQAGLGRQRADWLVGMNLSRAYTILGRRAQYRGVLSVGRVQSPTLALVVRRDRAIETFVPRDYWAVKALVRVDGGEFWARWKKPEPAPEWLDEEGRIVVQAEAERIVRATQGQTGQITRFETKPGKEEPLLPFSLATLQIFASAKWGYSAKEVLDACQYLYSEKKCFSYPRTDARHLVVALQAQIPDTLSAIAQTLSMLSPACAKADSSILGKAWDDSKVGEHYALIPTSEAADFASLTPIQQNLYRAVAQRYITLFYPDCLIERTSVEATVAQEVFAASGRVVKSEGWREVYAGEAPEPETPDANGKVAEEKEDEQRFPQMSLGQSAKAAQTVSEQKRTKPPTRMSDSSLLLAMTNVHQLVKDPQLRQRLQSSKGIGTSATRAAIIENLVEKGLLLREGKTLISSSAARVLIDALPATLLDPALSAMWENALDLVAAGKAPLDLFMQKQEAWLRQLLEKAQATGLGALSDAPLANANAGGASRGSGSGSRAGSSSGGSRSAGTSRSSSGSTASSRSAPQTGAGQNAGSGSRTPAPREIGHESSKTAPSAAVKACPECKTGKMVVRQARSGPSAGKPFLGCTNYPRCKHAERMPEKEPAR
(968) DNA topoisomerase [Burkholderia mallei ATCC 23344]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDMDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDHLGTVTEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKGEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIAEVEELLRKKEIGPLSGFRSKMGRPFSAILKLTFDDETKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQTDGKIGFEFEKKEPKPAAAKKTAARSSAAADDAAADSGEKAEKKAAPARKTAARKTPARKTGS
(1544) DNA topoisomerase [Ralstonia solanacearum Po82]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYYESDDHVLSSAVGHLVEIAAPDEYEVKRGKWSFAHLPVIPPHFDLRPIAKSESRLKVLTRLIKRKDVTSLINACDAGREGELIFRLIAQHANTKLPIRRLWLQSMTPQAIRDGFAQLRSDDDMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKRFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKNEFDAEQRESRLWSEAEAKSIVAACRDKPGTVTEESKPSTQMSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYMGTVKQTLDMLADSSPNYLPHAKKILNSQWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEYLVTTRVTEVAGHHFKTEGKVLVNPGWLAVYGRQAEGQGEDANLVPVAKDEKVKTDKVEPVSLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLLREGRELIPTAKAFQLMTLLRGLGVEELTQAELTGEWEHKLAQIERGRLARDEFMREIAQMTQQIVKRAKEYDSDTIPGDYATLSTPCPQCGHVVKENYRRFACSHCDFSISKIPGGRQFELEEVEELLINKTIGPLQGFRSKMGRPFAAILKLAQEDGHWKMEFDFGQNDGDEDGEPVDFSGQESVGHCPKCSGNVYEHGLKYVCENAVAQPKTCDFTTGKIILQQEISREQLHKLLTEGKTDLLTGFKSARTGRVFKAFLVKQPDGKIGFEFEPRGEGKAGAKTAAKKTTATAKKTAAAKAPAKAPAKTAAKAAAKKTPARKKAVAEADEESTSET
(819) DNA topoisomerase [Ralstonia eutropha JMP134]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFASLRADEDMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVHAEFIAAAGLYEGRWFDPKFKKSEFDPEARESRLWSEAEAKSIVAACRDKTGTVTEESKPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMETVKQTMTMLADSSPNYLPHAKKILSQGWVKPNKKIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKVESVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMLEIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENYRRFACMACEFSISKIPGGRQFEIEEVEELLLKREIGPLQGFRSKMGRPFAAILKIAKDDEGHFKMEFDFGQNDDEGDGEPVDFSGQEPVGTCPKCGGAVFEHGMKYVCENSVASPKSCDFTTGKIILQQEISREQVGKLLNDGRTDLLTGFKSSRTGRNFKAFLVRQADGKIGFEFEAREPKAGAKASGKTASRAAAETGEAEAAAAKAPAKKAAATKTATKTTATKTAAKKAPAKTVAAKKTRAAGKATVEAEE
(220) DNA topoisomerase [Dechlorosoma suillum PS]
5
MGKQLIIAEKPSVAADIAKALGGFTKHDDYFESDNFVLSSAIGHLLELVIPEEYEVKRGKWSFAHLPVIPPHFELKPVEKTESRLKLLTKLIKRKDVDGLVNACDAGREGELIFNYIARHAKSGKAVQRLWLQSMTPQAIRDGFARLRRGEEMQGLGDAAVCRSESDWLVGINGTRAMTAFNSKTGGFHLTTVGRVQTPTLSLVVERERKIREFKARPYWEVEATFAAAAGEYKGKWFDEAFKGKDEDEHARADRLWDEARAKALQAKCEGQPGEVSEEAKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYLGTVQATLQMFNGENLTKGSDTSVVDRYGIFANKILKSKWVVPNKRIFNNAKISDHFAIIPTTQAPKNLSEPEQKLYDLVVKRFLAVFFPAAEYLITTRITRVAGEPFKTEGKVLVNPGWLAIYGREGQEGDEGNLVAVSQGEKVQTEEVAVNQNETRPPARYSEATLLSAMEGAGKMVDDEELRAAMAGRGLGTPATRAQIIEGLITEQYLHREGRELIPTAKAFSLMTLLNGLGISELTSPELTGEWEWKLAQIERGDLSRSAFMQEIEEMTRHIVDRAKSYDSDTVPGDFGLLKSPCPKCGGLMRETYKKFQCGDCDYGLWKIVAGRQFEPEEIETLLTERQVGPLMGFRNKMGRPFNALIKLNDKNEPEFDFGQDRSGEDGGEPVDFSGQESLGPCPKCGSPVYEHGLAYVCEKSVGPAKSCDFRSGKIILQQAVEREQMQKLLSTGRTDLLKDFISARTRRKFSAFLVKGKDGKVSFEFEKREPKAPAAKKTAAKAEPKAAVEKPTKAPAKRKAKEA
(808) DNA topoisomerase [Dechlorosoma suillum PS]
7
MSKILIIPEKPSVAQDIAAALGGFSKREDWFERDDAIVCSALGHLVELACPEAEDPGFDLARLPAIPSRFNLAPIAKTSARLSLLKKLMNRQDVQLVVNACDAGREGELIFRYIYLCCGCRKPMQRMWIQSMTPAAIKEAFAKRRPGAELDGLFNSAQSRSEGDWLVGINGTRAYSILETRVTGERTLSTVGRVQTPTLALIVAREEAIRSFIAKPYYEIQGEFAAKTGVYGAKWIDTAFQADPSTPDARAERLFDKAKADAIVAKCTGKRPSSVADATTDSISTPPKLFDLTTLQREANKKFGFSASQTLAIAQALYEKQKVLTYPRTDSSALPEDYLDTARATLTRLGDGGLTVSPFAAKAVAMVKPDKRIFNNAKISDHFAIIPTGLVSATLSGEEAKIFDLVSRRFIAAFFPPAKYLQTVRLTVVEQETFRASGRVLVEEGWLAVYGKEADDSEDPALCAVAKDELPENRRIEAVSLKTKPPLRFTEATLLGAMESAGADIEDDELREAMKDRGLGTPATRASTIEALLADKDGKGRSIQPYVVREKKNLAPTNKAFKLVKFLRENGLTALASAETTGLWEFKLREMEKGRCQRSDFMGEIAALAREFVTRVQALAKDLPASAAMQAKPMAAACPKCGNTTMGATAKTFSCSCGFRIWREVAGRVLSDTEGEKLIAQGSLPTLAGFTSSKKKPFAAGLKLAEDLSGKVDFVFEQHTESSEAAAVACPQCGKPMRRRKGGTGFFWGCSGYPDCNHTMDDKDGKAVPKQPKVARQAGKVGETCPTCQKGKLTGRQSNGTSFLGCTKYPACRHYERV
(127) DNA topoisomerase III [Variovorax paradoxus S110]
5
MKTLVIAEKPSVAQDIVRALTPVAGKFDKHDEHFENDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPHFDLKPVDKTKTRLNAVVKQAKRKDVTQLINACDAGREGELIFRLIEQYAGGKTGLNKPVKRLWLQSMTPQAIRDGFDALRTEKQMQGLADAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRKFVSRDYWEIHGVFQAEAGQYPGKWFDANFKKPPPGPDGTADAEIRADRVWSEREAREIADAARGKPASVTEESKPTTQASPMLFDLTSLQREANGRFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVVKDTMKMLAESGMKHLAPFAQQAVDGSYVKPNKRIFDNAKVSDHFAIIPTLQAPSGLSDAEQKLYDFVVRRFMSVFFPSAEFQVTTRISTVEAGGKKYPFRSDGKVLVKPGWLAIWGKEAISDDDEKDGKNLVVVKPGETVKTESADLKALKTRPPARYSEATLLGAMEGAGKTIDDDELREAMQEKGLGTPATRAATIEGLITEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSKAELTGEWEYKLAQMEKGALSRDAFMREIAEMTQHIVKKAKEYDRDTVPGDYATLSTPCPNCGGVVKENYRRYSCTGKAGQEPCGFSFGKSPAGRTFEVAEAEVLLRDKHIGPLEGFRSKAGWPFTSEIVLKYDEEAKNWKLEFDFGDDKNADTGEIVDFSEQDTVGPCPICGAPVFEHGSNYVCEKSVPTTAQPTPSCTFKTGKIILQQPVERAQMEKLLATGKTDLLDKFVSMRTRRAFKAFLTWNAEEGKVTFEFAPREGGSKFPPRKTFGKAAPAGKTAAAKKVAAKKTPAAKKAPAAKKAAAPRKPGAGLKPSDSLAAVIGAEPVARTEVIKKLWDYIKANGLQDAANKRAINADAKLKPVFGKDQVTMFELAGIVGKHLSAP
(1054) Candidate type IA DNA topoisomerase [Ramlibacter tataouinensis TTB310]
5
MSKTLIIAEKPSVAQDIVRALTPVAGKFDKHDEHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKGRLNAVVKLAKRKDVTELVNACDAGREGELIFRLIEQFAGGGNPLGKPVRRLWLQSMTPQAIRDGFEQLRTDRQMEGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLAVVVEREEQIRRFVSRDYWEIHASFLAEAGEYPGKWFDPKWKKNPDDAEQKADRVWTLQEAQAIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGRFGYSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLGTVKQTMQMLAASGMRHLAPFAQQAIDGNYVKPTRRVFDNSKVSDHFAIIPTLQAPSGLSDAEQKLYDLVVRRFLSIFFPSAEHLVTTRINQVVGHHFKTEGKVLVKPGWLAIWGKEADVEGDENSKTLVPVKPGEMVRTESVEARGLKTRPPARYSEATLLGAMEGAGKLVEDDELREAMQDKGLGTPATRAAIIEGLINERYMFREGRELIPTAKAFQLMTLLRGLGVEELSRPELTGEWEYKLAQMERGQLSRDAFMQEIAEMTKHIVKKAKEYDRDTVPGDYATLKTPCPNCGGVVKENYRRYSCVGRKGDGSDACGFSFTKIPAGRAFELHEVEQFLRDKRIGPLEGFRSKAGWPFTAEIALKYGEEEKNWKLEFDFGDEQDPSETGELVDFGAQQPLGPCPKCAARVFEFGKNYVCERSVPTPQQPTPSCDFKTGQIILQQPVEREQMQKLLATGRTDLLDKFVSMRTRRPFKARLAWDAEAGKVNFEFEPRESKFPPRKGAGAARPATGKTAPRKAAVGRKAGAAIPADKGTAAAKKAAGAKPVAAAKKAAAPKAPRKTGPGLTPSPQLAAVVGAEPVARTEVIKKLWDYIKANGLQDAANKRAINADAKLAAVFGKPQVTMFELAGIVGKHLS
(1716) DNA topoisomerase III [Acidovorax citrulli AAC00-1]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKLARRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLNKPVRRLWLQSMTPQAIRDGFGNLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRQFVSRDYWEIHAGFHAEAGEYLGKWFDPQWKKVADDPEARADRVWSFERAREIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKDTFGMLATSGMRHLAPYARQALDENYVRPSKRIFDNAKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYLVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEYAEAKALKTKPPARYSEATLLGAMESAGKQVEDEELRSAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTTKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTERMVKKAKEYDRDTIPGNYATLSTPCPNCGGVVKENYRRYACTGADGRGDGCGFSFTKSPAGRTFEPAEAEALLRDRRIGPLEGFRSKAGWPFTAEVAIVRDEEAGNFKLEFDFGDDRAGEASGELVEFTGEPLGPCPICGAPVHEHGSNYVCSKAVPTAAQPTPSCTFKSGKVILQQHVEREQMAKLLATGKTDLLDKFVSMRTRRNFKAFLAWDKEAGKVNFEFEPRESKFPPRKFAGKAGAAAGAAKAGTAAAAKKAAKPAAKAAAKKSTAAAKAPRKTAAGKPPSAALAAVIGPEPIGRPEAVKKMWEYIKAHNLQDPKDKRTIKADAKLREVFGKESAGMFELAGILGKHLQGDSE
(1283) DNA topoisomerase [Acidovorax citrulli AAC00-1]
4
MRVVLCEKPSQGKDIARVLGARQREAGCLAGPGIKVTWGIGHLIEAAPPEAYGEHFQRWSLETLPIVPQQWRWVVKADTASQFKVVQRLLAQASELIIATDADREGEMIARELIEYCGYRGPIQRLWLSALNDASIRKALGALRASHETLPLYHCALARSHADWLVGINLTRLFTLLGRKAGFDGVLSVGRVQTPTLKLVADRDREIAAFVPVPFWSIEVSLSAGAQAFSAHWVPPATVTDAAGRCLQQSAAQHAAAAVRTAGHAQVTGIDTERVQEGPPLPFDLSTLQEVCSRRLGLDVQETLDIAQALYETHKATTYPRTDAGYLPENMLTEVPTVIRSLLKTDPALQPLMQRLDLGQRSRAWNATKIAAHHAIIPTLEPADLSKMSEKELAVYRLIRAHYLAQFLPHYAYDRTMVRLACGGQALQASGKQVVDAGWKAAFAAPSIPGAGAETPEAETDSEAPRDQALPTLHEGMACEVRSLDLKSLYTKSPPPYTQGELVKAMKTVAKLVTDPRLKQTLRDTTGIGTEATRANIISGLLARGFLVRKGRVVRASKTAMTLIDAVPAAIADPGTTAIWEQALHMIEARTMDLDTFVSKQAAWVSQLVEQHREATLAIRVPAGPPCPLCGAATRKRTGKTGAFWSCSRYPDCKGTVAIDSAEAGRRNGPRKPRAARKLH
(1703) DNA topoisomerase 1 [Nitratiruptor sp. SB155-2]
1
MGKNLIIVESPAKARTIKNFLGKEYEVIASKGHIRDLPKSSFGIKIEEDKFIPQYRVDKEHSQITKQLKELAKKADTVYIATDEDREGEAIGYHIAEAIGKKPQELPRIVFHEITKSAIQKALQNPRTIDMNRVNAQQTRRLLDRIVGYKLSPLLSSKIQRGLSAGRVQSAALKLVVDKEREIQAFKPQEYWSIDAIFNDTIEAALYEYMNKKIGKMDIKNEKEAQAIVDQVKNESFVVAKIEKKKRITKSPAPFMTSTLQQTASSKLGFSPKKTMMIAQKLYEGVQTPKGITGVITYMRTDSLNIAKEAQEAARDLIKKQFGEKYLPKKPKEYATKSKGAQEAHEAIRPTMLDFTPEVAKNYLSADELKLYTLIYNRFLASQMEDAVFETQTIYFKSPSATFKASGRKLIFDGFYKVLGNEDKDKLLPDLKEGEEAKLTKIEANQHFTEPPARYTEASLIKMLESLGIGRPSTYAPTIALLQARNYIELEKRAIKPTEIAFKVIEVLEKHFPEIVDSSFTAKMEEELDEIAEAKKDWQKVLKAFYDPFIELIEKGKKEIKSQKVAIPVGRNCPECGAELVKRKGRFGEFIACSAFPKCKYTEQIESEEKGPQESNEVCEKCGSPMVVKQGPRGSFLACSAYPKCKNTKPLAKNEPKKLDVKCPECGGEIVERFSRRGKFYGCSNYPKCTFVSKFEPVDKQCSECGYMMAKRTYRNKEVYECIKCKHREEVQ
(69) Reverse gyrase [Nitratiruptor sp. SB155-2]
6
MIDLVYKGLCPNCGGDICSDRLDKGLLCKRCMPKEGEPCEVLKEGEFVKVCEVEQRSVEFEAFFKEKNGFLLRQIQKSWAKRFFLGHSFALLAPTGVGKTTFGLSLASFLDQKSYLLFPTQLLVNQAVEKLRLLGIEPLFYDSGFSKSKKDEVKAKIASGDFEILVTTTAFFYKNFDSIPKAFGFVFIDDVDSILKSARNIDKVMLLLGFSQEDIDAAMQFIDHKIKGDLSYEEFEQWQAKIEAIRSHAKAQLIVSSATANPRSRRVGLFRELLGFEVSRPSITVRNVEDLYEKPEKLWERSVELVERLGRGGLLFLPGNETKERLQEFLAFLEQKGVKAQSYEDFDAKAFEEGEVEVLVGFASYRNPLARGIDMPATIRYALFVGVPKLEFTLDITKHTSLYFFLLALLPVIRNHPNFHQFMQYVNYLKRLVRVPTERLNEKAKARVQTIYHDILAILDEELIDAINKTPDVSLVKEDEYFKIITADVTGYIQASGRTSRLYVGGLSKGLSYLLVDSEKTFSSLQKKVRWFSEEIVFKSAKEADIDAILKIIDEDRKKIALALQGKFQEAKEFFTTSLVIVESPNKARTIANFYGKPMVRDLGGIRVYEVAKEGKILSITASKGHVVDLQKQEGVYGVLRQEHFIPLFEPIDENKRRIIEALRRIGVEVQDVYIATDPDVEGEKISYDLQLLTKPYNHTVQRAEFHEVTKRAFDEALSHPRDFDENLVKAQLVRRIADRWIGFSLSQMLQKKLQKSWLSAGRVQSAVLEWIVLREKEAKEKIFVVHVSFRGLEAEFVFDEKQKAKDFYERLEVVEVRFIQKETKELFRTPFTTDAMLYAASSELHFSPQKTMQLAQDLFESGFITYHRTDSTRISSVGIAIAKEYIQSRFGQDYFVPRSHSKAGGAHEAIRPTKAMDAQELEQFLQMQNSNLTQDHLKLYDLIFKNFIASQMKSAKIEEIAAQVEAFDQKTTIRFYDEIVEHGIDLILPVQLHQLQEGRYAVQKELLTRSKVPKYSYADVIRLMKERGIGRPSTYAITIQKLQERHYIVQRRGILYPTKLGQEVYEELRKNPEVYTFVNEHYTKELEALMDRVEKGEVSYEEVVESLYLQLKERIEF
(279) DNA topoisomerase 1 [Pelobacter carbinolicus DSM 2380]
1
MAQSLVIVESPAKAKTIEKFLGPGYKVLASYGHVRALPSKQGSVDVEHNFSPLYHVLPESQKHIELLKKEAKKSRELILATDPDREGEAIAWHLLEALGIDENAKSPEVKRVTFHEITKGAIQEAISKPGHIARELVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPARLYAVDGNSLGKFDINQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQEASRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVALSQVATGEARELITRMYGEDYALDKPRVFKNKAKNAQEAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLIWQRTVASQMATAQLEATTVDIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQEEGTLPPLEQEQPLDCQEVQPSQHFTQPPPRFTEASLVKTLEEHGIGRPSTYASIINTLTTRKYVRLEKRAFYTEDVGMVVNDLLVNHFNKYVDYDFTAQLEEDLDAISRGEREWQPVLKDFWEPFISRLKEKETQISKQDVTTEKTDRICPECGKPLVIKLGRSGRFLACSGFPDCRYTEPLAGQEREEPVMSDQTCEKCGAPMLIKQGRYGKFLACSAYPECKNIQPLVKPKALGITCPQCGEGELMEKKSRYGKIFYSCNRYPKCKYALWDLPIEEPCPKCKFPLVVEKTTKRQGTFRKCPQEDCDWTVVLIPPEPKAATKKTTTQKTAAKKTPAKKTAAKKTTAAKPAEKKTASKKSAAAKPAAKKTAAKKTTTTKAATQKAAPKKTAAKKATKKEE
(113) DNA topoisomerase III [Azospirillum brasilense Sp245]
3
MAVMATLIITEKSSQAKDLRAALGDRYGRILPAEGHLLRLAEPDEVNPDWKRWSPTLLKPDGLYPTKPDSGGNKTAKLAAIKAALKGCDQVILATDCDREGQLIGQEILEHLGFRGRVQRALFTAQDPKTIRDAFAKLKPNNELRPLYEAAVARQQADQIFNLSLTRTATKTLLAPGTRGVIGIGRVKTPTLSIVCLRELEIRNFKPEDYFEVVATATAAGGSFLMRHAPPPKDRIKDRARAEAIARAADGHGGPLSVTVEDRRQAPPKLYDLPALQKTCGQRWGWTADRTLEVAQELYDGEGKKLITYPRAEARYLSENQIADVPAIAGALTRLRGFAHLDISRPVIRRGKSGHFCDKALEGVSHHAIVPNVNVLDDLESRLNRLTDDEKRLYALICRSYLAAVMPDYEYRQTTVLMNVPVEGKPVVFRAVGRIPLKLGWKAAFGSAETDGKPDEKEEEQTLPPLTDGEPARLSEPRVEAKRTQAPPRYNEGTLVDAMQNAWRFVEDLALRDRLKEAKGIGTPATRAEIIKGLRRQNLLGADGKWLVPTPAGLQLFETLRGAAPTLVDPGTTALWEMRLDEVVVGRADFRSVIDGIADEAERLIGVLVGNQGSAVDLGVRGGPIRAGRGAGRRRSTSPRAAGAPPRPRTRKAAAAAVGVDGEAPKTPRRSRKAKAAPEVPGSIGPVADAVPPSPAAPSIGARRKAPTDKMVAFARSLADRKGVELSDTVLQDFDSCRQFLDQHAR
(751) DNA topoisomerase 1 [Helicobacter acinonychis str. Sheeba]
1
MKHLIIVESPAKAKTIKNFLDKNYEVIASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKDLVKQIIELSKKASTTYIATDEDREGEAIGYHVACLIGGKLESYPRIIFHEITQNAILNALKTPRQIDMSKVNAQQARRFLDRIVGFKLSSLISSKVTKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDALFEPNLEAQLVSYKGNKIKAQELIDGKKAQEIKNELEKESYIISSIVKKSKKSPTPPPFMTSTLQQSASNLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARDKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSVILEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQNVVVACEKGEFKASGRKLLFDGYYKILGNDDKDKLLPNLKENDPIKLEELESNTHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQIRALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGESCPKCGGELVKKNSRYGEFIACNNYPKCKYVKQVENAHNEAKQELCEKCGGEMVQKFSRNGVFLACNNYPECKNTKSLKNTPNAKEMIESVKCPECGGDIALKRSRKGSFYGCNNYPKCNFLSNHKPIDKRCEKCHYLMSERIYRKKKVHECIKCKERVFLEEDNG
(1712) DNA topoisomerase [Desulfotalea psychrophila LSv54]
7
MTTKILIIAEKPSVAGDLAKVLPGKFTKQKTHYESDSHIVSYAVGHLVSLCYPEEIDPIYQKWGLANLPILPESFPLKAVENTKSQLNALKKLIRRKDVTEIINACDAGREGELIFKYILKYVWNTSVAKKTIKRLWLQSMTAESIKKGFNNLRENDTMQSLEDAALCRSESDWLIGLNATRALTGFNSRKGGFFLTPCGRVQTPTLSLIVKREAIRNGFTPTDYNCLQANFSFETGSYSGKWIDPNFKKDPKNSYLRQDRIWDKQKALAILEKCQQKPANATENSKESRQSAPQLFDLTALQREANSRFGFSAKNTLGIAQALYEKHKALTYPRTDSRHLPEDYVDTVKEITQNQTGWEFAAIAKTALKEGYIKAQTRIFNNKKISDHHAIIPTNTLPQNLSEPELKIYTMVVQRFLAIFFPPAVFHNTKRYSLVEGQTFLTEGKILLEAGWKVVYAGADGSTGKDKILAPIPTGSPVTCNKIEKEALTTTPPARYNEATLLSAMENSDKFIENEELADAMKERGLGTPATRATIIEKLIKEKYVVREAKDLVPTGKAFELFSLIEAMKIDTLASPEMTGEWEYKLNQIFKGEMTRDDFMQEIRQLTQQIVDRVRDFNTDEERSLAPFSPVGETVIYSTPTAWVSEDGTIAIRKVLGGRLMSNKEIVALLEGKSLGPFSDWRSKRGKNFTATVSLKNNKIEFIFADSTADLDIDSIKKQEPLGLSPVDQTAVFETPVGYMSESALDGESKKGLKISKVILDKTISKENIQQLLTDGKTELIQGFISKRKRPFDAYLLMDKKGKITFEFPPRKPKNKPQD
(1373) DNA topoisomerase 1 [Syntrophus aciditrophicus SB]
1
MPDSLIIVESPTKVKTLKKYLGADYEVLASKGHIKDLPKKTLGIDPQNEFQPTYSVIDDKKKVIADLKKAAKNVSRIFLAPDPDREGEAIAWHIAEEIKAKNKEIYRVLFNDLTKNTILDAINHPGKLDFNKYEAQQTRRILDRLVGYQISPILWEKVKRGLSAGRVQSVAVRMICDREEEIKRFIPEEYWNISVQLKGVTPPPFEARLIKITGKKAKVKNEAQANEIVSRLSGGVKSGSKPTINLSEDRDLQPQFVVSKLEKKEVKKESLPPFTTSKLQQEASRLLRFSAKKTMATAQKLYEGIELGEEGPVGLITYMRTDSVRIAEDALKEVRSYIRENYDPPFLPAKARFFKSKGKTQDAHEAIRPSSMNYNPQKIKHFLSADQFRLYQLIWNRFVASQMNPALYDQTTVEVSADFYTFRAQGAILKFPGYTIVYTEGKEDKEQNEEMESGKILPDLNEGERLTLLKITPEQKFTQPPPRFSEASLVRELEEQGIGRPSTYAAILSTIQDRNYARLEQGKFHPTELGTIVTELLVKNFPKVMDVSFTASLENQLDLIEEGKQKRIETLQEFYAPFEEDLSKARLEMKNIKREETPTDLICEKCQSPMVIKWGKNGKFIACSNYPACKNTRNIEQGEGVERSAKGGEMTDTVCPKCGKNMLIKHGRFGRFLGCSGYPDCKHTMPISLGVKCPQEGCDGEIIEKRTKKGRSFFGCSNYPNCTFAVWDKPIPEPCPQCNSPFLVEKYSRTEGSYKACPNKDCGYRDDQS
(368) DNA topoisomerase 1 [Desulfohalobium retbaense DSM 5692]
1
MSTDLIIVESPAKVKTIRKFLGSDYLVEASVGHVRDLPSSNLGVDEDNNFQPQYQIISGKQKVVSRLKSAAKKATTVYLAPDPDREGEAIAWHVAELLKKTNTNLKRIQFNEITSRAVKDALEHPRDLDERLFYSQQARRILDRLVGYKISPLLWKKVKRGLSAGRVQSVALRLIAERERERQQFDPQEYWVLKAHVQAAAPPPVVAELWKIGGKKPHVANETQALEIEKKVSEAGFHVESVEEKERKRHPKPPFITSTLQQDASNRLGFAAKRTMRIAQQLYEGLDLGDKGTTALITYMRTDSVRISNEARNAAQKWIVSTLGEAYYPEKPRYFKTKGSAQDAHEAIRPVDPTLTPGSIQSYLSREHFRLYKLIWERFMASQMAPARFWDTQLTLASANTLWRAKGERLIFDGYLRVYSADKSQEEVELPKVQAKDALTLEKIDKEQKFTQPPARFSEASLVRKLEELGIGRPSTYAQIISTLLDRNYVQLAKKQFVPTEMGFVVADLLTAHFPQLLDVGFTAEMEKKLDSVAEGDQDWTQLLREFTESFYPTLEKAEQEMQQVKTGVETGVSCPKCGKPVVIKFGRNGEFLACTAYPDCDFTSNFTRDEAGTIVIVEPEPQERQKVGTCPECGQDLVLKKARTGSRFIACTGYPKCKYTQSYSTGVKCPKQDCPGELVEKSSKRGKVFYACNQYPDCKTAYWNWPIAEECPTCGSPILVRKETKARGEHVACPEKGCGYWRELRDDEKH
(1600) DNA topoisomerase 1 [Desulfovibrio aespoeensis Aspo-2]
1
MPKDLIIVESPAKVKTISKFLGKDYMVDASVGHVRDLPTRDLGVDEENGFTPRYEIIQGKEEVVKRLKAAAKKAGTVYLAPDPDREGEAIAWHVAELLRPVNSNIRRIQFNEITARAVKEALENAQDLNQNLFDSQQARRILDRLVGYKISPILWKNVKRGISAGRVQSVALKLLVEREKERRAFKTDEYWPFKVLLEGGNPPPFWLELHKLSGKAVKPGVNHISTQAEAEALQQTLEAGQFTVDSVQEKQRKRDPLPPYITSTLQQDANRRMGYSAKRTMSVAQRLYEGVELGRHGTTALITYMRTDSVRIAKEAQEAARELIIDRFGADYYPSKPRNFKTKGGAQDAHEAIRPVDVTITPDDVKSSLPSEQHKLYRLIWQRFVASQMAAASFWDTTVLVSAPATEWRAKGERLLFPGFLAAMDKSGTEAETELPKLVEGETLRLNELKKEQKFTQPPPRYSEASLVKTLEELGIGRPSTYAAIISTLLDREYARQEEKRFVPTELGFTVSDQLSEHFHALMDVGFTAQMESLLDDVAAGKQDWAKLLKDFGHDFYPTLEKARTEMARSQQETDIVCENCGKPMSIKFGKTGEFLGCTGFPTCRTIKNFTRDENGAIRIVERETPEETGVECEKCGKPMAIKQSRRGEFLGCTGYPDCKNIVNFQRDENGAISVIESEKLQVVGSCPDCGGELLLKKARTGSRFIACSNYPDCTYAAPFSTGVPCPVEGCAGELVEKSSRRGKIFFSCSAYPKCDYAVWNWPVNEPCPKCGHPILTRKTTKDKGEHLACPQKGCGYTREPDEPADTPDTPDLPDMPDDNA
(852) DNA topoisomerase 1 [Desulfovibrio vulgaris DP4]
1
MGKDLIIVESPAKVKTIKKFLGGKYVVQASVGHVRDLPTNEIGVDEANNFAPQYRVIDGKQKVVDTLREAAAKADTVYLAPDPDREGEAIAWHVAALIEGKADNIKRIQFNEITARAVREALENPRDLNRALFDAQQARRVLDRLVGYKLSPLLWKKVKRGISAGRVQSVALRLIVDRESERRAFTPEEYWLFRAMFAKNVPGATPTSPDPQYAPFKAELAKIDGKKAHVADADAANALEDAMRGKPFVITAVERKKRERQPQPPFITSTLQQAANQRLGYSAKRTMNIAQRLYEGVELGEMGTVALITYMRTDSVRVSDEARDAARAFVTETWGADFCPAKPRQFKTKGSAQDAHEAVRPVDVNVTPDSVKHLLPPDQFQLYRLVWSRFVASQMAPARFDDTTVAIACGPAEWRAKGERMLFPGFLAAMPQKEEGDAELPPLQEGETLHPVSVEKEQKFTQPPARYTEASLVRELEERGIGRPSTYASIISTLIDRDYTRLEDKHFVPTDLGATVCDLLARHFTTLMDVGFTAQMEDSLDKVAEGGLDWVELLSRFSADFNPTLESAAKAMETVKGGLPTNVTCPECGKPVVVKFGKAGPFLACTAYPDCKFTSNFSRDEKGDIVIEQRAREELEAVGTCPECGKDLVVKKARTGSRFIACTGYPDCRHTEPFSTGIACPREGCDGQLVEKSSKRGKIFYSCNRFPKCDYALWDWPVPGPCPVCGSPLLVKKSTRAKGLHIACPEKTCRYTQELPDDEG
(749) DNA topoisomerase [Desulfovibrio vulgaris DP4]
7
MSKTLIIAEKPSVAREIAPLVGAQGRRAGYLEGPDHLVSWAVGHLVGIAEPEEQDEAWAGRWTLEQLPMLPPRFQLRVLPETADQFAVLQRLLLDDRVTGIVNATDAGREGELIFRRIYLVAGCDKPVRRLWASDMTEEGLRKSLARLLPDEEKRNLGLAAFARAEADWLVGMNFSRLFTVKSGGLVSVGRVQTPVLCLLADRRRDIEHFTPQDFWTVEATFDKNLDAGTSTGTRPMTSPAARSTVPCLAESGPATGDAPPAPDGDRTTQSEAQTDEGTKPDAQADALSDASSAAPATSAPDTPVASDVPDAEIAAPEAAANDDRFRGVWHRPPDRRETRVDSGEEADAIATACTGKLGIVESVQGRAGTQQPPLPFDLTTLQREANTRFGYSAKDTLTHAQSLYETRKLITYPRTDSRHLTKELFGEILNHLRAVHHLYPEETMLAVGRIKSGKARFACVDDRKVTDHHAIIPTARKGNLTQLSAPERNIYDMVCRRTIAAFCPEAKFSTSTVTVMVGEHPFIAKGKVFKDKGWMVVEPWRTAEDTPLPQLRKGSKLLTLDVGPVKRQTKAPAHFTDASLLAAMETAGRLVEDDALRQAMKERGLGTPATRAQVIETLVARGYVAKQGKKLVATDRGMQVAETVTTLLPDVASPELTGQWEKRLKDIEAGVDSYPAFMRSIRESVWHGVHRIRNRDIRPLLRDIAARNSRPPDGRCPLCGGDVVETPRGFACKGDSKGKTEGDSTAARCPFIIWKEMHGKAMDEDIVRELLAKGRTAEAFDLTSRQGKSFRAHLVLEGGRVGLDFVRDRTPFRRDEDPQRTVHATGARPAAVPDVDTTSDAHPGADDASAPLTESSHAEGG
(1668) DNA topoisomerase 1 [Helicobacter bizzozeronii CIII-1]
1
MKANPKKLIIVESPTKAKTIANFLDQNYQVIASKGHVRDLSKYAMGIRIQEDKFIPKYIVDKDHEDIVEQILSLAKSASQIYIATDEDREGEAIGYHIAYLIKENQRTSQTKKMSANQILQETLDLEQQTNHAPSSNPIFHFPRIVFHEITKSAILHALKHPKTLDVYKINAQLARRLLDRIVGFSLSSLLASKIAKGMSAGRVQSAALKIVVDREREIQAFKPLIYYNIEGIFEGCIEASLESYLGEKIKKQSLTDAPDALKMVAHLRAQTYQVQEITHKNKTSPSPPPFMTSTLQQSASTHLGYGPSKTMGIAQRLYEGVATPEGMSGVITYMRTDSLNVAKEAIKAARDFISTTYGAPYLPNKPKTYTAKNKAAQEAHEAIRPTNLNFTPTIAKDYLKPEEYRLYTLIYNRFLASQMTDALFENQTLRLSCADGTFKASGRKLIFDGYHRVLGECDRDKLLPALQKDQSVRLDKLEAKKCSTEPPTRYSEASLIKTLESLGIGRPSTYAPTIALLANRSYVKLENKQLVPTEDAFVVIGILEKHFSEIVDAAFSAGLEDKLDAIASSKASWQQVLFDFYTPFMDKIEAGKAQIASQKSSVPTGEFCPECGLELVQRKGRFGEFVACSGYPKCKFVKPPSEQTPTPLEPCEKCGKPMVLKKGRFGEFVACSGYPQCKNIRSKAPQLKEEKVAGVCPECGGHVVEKRGRRGLFYGCANYPQCQFISNYPPSDQKCPECGYVLVFKAYKRKPSVWACLKCAFTRLADV
(1158) DNA topoisomerase I [Helicobacter bizzozeronii CIII-1]
3
MQKPDVIIIESPNKIKKIASITGAKVLATIGHFMELEGIEGENFKPKFAYRADKKQQIYAMIEQCKGKRVYIATDPDREGYAIGKMFYEKIKNVAKEVFRAEFHEITESGINKGLQSALLFANTNSNHYESFLARSVSDHYIGFTLSPYLGDCLQQRKGNSVGRVQTPCLKLIVDRDKEIEAFKALPESQKVSYQIQAKIYDTHNREVILRHCNGEGKEIKYESQEQALAMLAPLKECKVALVLDIKHFTISSPPPKPFITSSLLKVGSTQLGLSTQQIQEHAQKLFEAGLITYIRTDAETLSQEFLYKAEKFYQPIYTNLYERRAYKAKNSQAEAHEAIRITHCHKFEDTQDILAQAGIADNQAQALYTLIFQRTLESQGKSAVYAKQDLQFKIKDHFFKCSVRSLKQAGYLDMFRHTEQAKSAEQAENEQNAHLDLKTDSTISLLSLDIAPIQKHAKSAYVEASFIEVLEKNGIGRPSTYASYLPKLTQREYIQITPDKKRIVNATHKGKQVISVFEASPYSWIVDTQFTALMEELLDKIVRQECSYVEYMQMIAQRCPQMPSQTPREEYPTRAPRESQVKYVQDILRDLKMELPSEFADYARDDKITKAFLDKFIPKHKEAREKAKQEGHYLGDNTPASKPATAKQVAFAESLSQKHNVKLPKDYKSNMQVCSGFIEEWKGK
(1815) DNA topoisomerase 1 [Sulfurimonas denitrificans DSM 1251]
1
MNLIIVESPAKAKTIKNFLGKEYEVIASKGHIRDLPKSRFGITVDENSHLIPAYSVAKENAATVKEITTLAKKSDIIYIATDEDREGEAIGWHIAHAIKKDPAELPRIVFHEITKTAIENALLNARKIDMDMVNAQQARRILDRVVGYKLSPLLSSKIQKGLSAGRVQSSTLKLVVDREREIRAFVAEEYWTIDTLFAKDIEASLISHMGEKLSKLSITNKADASSIVKSVKEDSFIISKIETKERRSATPPPFMTSTLQQVASSKLGFTPKKTMMVAQTLYEGVKTPSGTSGVITYMRTDSLNLAHEALTAVRGLIESRFGKKYLPAEPKIYTKKAKGAQEAHEAIRPTMLAFTPEVAASFLKPDEIKLYRLIYERFVSCQMNDAVFEQQSIIFSGANNEYKAIGRKLTFDGFYALTGAEDKDKLLPSLSEGQSAQIQKIESTQHFTEPPARYSEAALIKKLESEGIGRPSTYAPTIATLSNRTYVTIEKKQIIPTEMAFTVTEILEKNFSNIVDLSFTANMEEKLDEIAEGQNDWQKLLSDFYGDFLAQVEEGKTNIVSLKMATPLGRACPKCGEELLLRSGRFGEFIACSAFPKCKYTEQVEGEKKEGEENAQSSSSDEICDKCGKEMVTKNGRNGPFLACSGYPDCKNTKSINVEEKTSETPCPDCGGKISLKNSRRGPFWGCENYPTCKFISKFEPSKYKCRESGCDGALAFRVFRGKEIYECIKCKAKTPAQEIVAE
(1058) DNA topoisomerase 1 [Geobacter metallireducens GS-15]
1
MPQHLVIVESPAKAKTIEKFLGKDFRVMASYGHVRALPSKQGSVDVANDFEPKYAILPESKRHIDAIKKELKESDILLLATDPDREGEAISWHLLAALGMDKKKNAVPVKRVVFHEITKDAIVHAVENPRDISLELVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIKAFQEQEYWTIGAELGTGKGQKFSANLVEAEGKKLGKFDIPDGTAADRLVKALENGAYTVDKVAKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGVAVGDEGLVGLITYMRTDSVVLSNQALQEAHEVITSLYGKEYALAKPRFYKNKAKNAQEAHEAVRPTSIARTPVEVKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGYRFRAAGTVIRFPGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLQKLVPEQHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLLERKYARLDSKRFVPEDVGMVVNDLLTNHFTQYVDYNFTASLEEELDRVSRGEKQWKPLLHDFWGPFSSLLKQKEGEVSKADLTTEATDELCPDCGKPLVVKLGKRGKFIACSGYQEGCTYTRNIAQGEQQEPAEPVFSEEKCDKCGSPMLIKDGRFGKYLACSAYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPGPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
(1189) DNA topoisomerase 1 [Geobacter uraniireducens Rf4]
1
MPRHLVIVESPAKAKTIEKFLGTDYKVLASFGHVRALPSKQGSVDIEHDFEPKYAVLPESKKHIDAIKKELKNSDSLLLATDPDREGEAISWHLLAALGLDKKKPAIDIKRVVFHEITKGAIIHAVENPRSISHELVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFTEQEYWTIAAQLATGAQQNVTANLVEAEGQKLGKFGIPDKAAAERLTEILANGSYQVDKVTRSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSIAQKLYEGIDVGEGTVGLITYMRTDSVVLSQQALDEAHEVITSLYGKEYALAKPRFFKNKAKNAQEAHEAIRPTYICKTPVELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGYKFRAAGTVIRFPGFMKLYIEGVDDETEEKEGVLPPLNEGDPLKLKELLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYARLDKKRFFPEDVGMVVSELLVNHFTKYVDYNFTASLEEELDRVSRGEKKWKPLLHDFWEPFQTLLKQKEGEVNKSDLTTEATDEICPECSKPLVVKLGKFGKFFACSGYPECKYIRPLDKDKKDVAEPVISEEKCDKCGSQMLIKEGRFGKYLACSAYPACKNIQPLVKPKGTGIKCVECGEGELTEKKSRYGKMFYSCNRYPQCKFALWDLPVEKPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYKEGGKEK
(707) DNA topoisomerase [Taylorella asinigenitalis MCE3]
5
MSKTLIIAEKPSVATDLSKALGSFKKESGYYENDQYVISSSVGHLLTLHNPDDAVRGKWSFANLPAIPKRNFEIEPIDKKSKERLTLLTKLIKRSDIESIINACDAGREGELIFRYIIQYSKTKKPIKRLWLQSMTKQAIQEAFSNLRSDQSMKPLEDSARSRAEADWLIGINGTRAMTAFNSKGGGFHKTPIGRVQTPTLAIVYDRDKKIREYEPKDYWEVIGTFVASAGVYEGKWFDPNFKKNPKDPDARESRIWDANTAKTIVLACKGKEGTVSEEIKELSQNSPILFDLTALQREANSKFGFSAKTTLAVAQALYEKHKLITYPRTDSRYLPEDYLSTVKDNLKSITSMTSSLHKDHREFAEKILKNGWVKPNKRIFNNSKVSDHFAIIPTTGNSGTLSEAEAKVYGLICKRFMAVFFPPAIYNVTTRITDVFSYKFKTEGKILVSPGWLEIYGREEMDETLPQIKPNETVLTETIESVQNKTKPPAHFNEATLLSAMEGAGKLIDSDELREAMSERGLGTPATRASIIEGLITEQYLRREGKDLITTTKTKQLMTLLHGLSINELTSPELTGEWEYKLRQIEDGNLDRQSFMQEIAKNTQVIVKRAKEYEHDTVPGDYATLMTPCPVCGGVIKENYRRYACTNCDFSITKNPGSRPFETSEVEEFLSNRTIGPLSGFISKLGRPFSAILKLTDDNKLEFDFGNDDSEEGEEIDLQALTPIGKCPKCSSDVYDTGLSYACENQIKDKSCDFKSGKVILQQEIPVEQMQKLLVEGRTDLMDKFISNRTKRAFKAYLVLEKNGKVGFEFEKKTKAANKTGKK
(1164) DNA topoisomerase 1 [Nitratifractor salsuginis DSM 16511]
1
MKNLIIVESPAKARTISNFLGKDYKVVASKGHIRDLPKSSFGITVEEGKFIPKYTVPREASPTVKELKKLAKEAETVYIATDEDREGEAIGYHIAKAIGKDPEELPRIVFHEITKSAIQHALENPRRIDMQSVDAQQTRRLLDRIVGYKLSPLLANKIQKGLSAGRVQSAALKIVVDREREIKAFKPEEYWSIKGIFDKTVDADIYSFEGKKIEKMTLKNGEEANKIVESAKEESFKVASIETARRKSKTPPPFMTSTLQQAASTQLGFSPKKTMMVAQKLYEGVKTHKGTMGVITYMRTDSLNLAKEAVAEAREFIEKNFGEKYLPAKPKFYASKAKGAQEAHEAIRPTMTEFTPKLAAKYLAPDELKLYRLIYNRFLACQMTEAEFETQTILFAGEKSVFKATGRKLIFDGFYRITGYNEKDRLLPELKEEQPVELTEIKAEQHFTEPPARYNEASLIKKLESLGIGRPSTYAPTITILQNRKYIEIEKKRIHPTEIAFTVIEMLEKHFPEIVDSNFTARMEETLDKIAEGKEDWQKVLWEFYQPFIEKIAEGKKNIPSQKMAEPIGEKCPECGAELLKRKGRYGEFIACSNFPKCRYSRNIDGTEPEKPEETDEICDKCGAPMVIKNSRRGKFLACSAYPKCKNAKPLTPPKELAVPCPECGGKLIERQGRRGTFYGCANYPKCKFIANFEPVDKKCPECGYLMGVKHLKSGDVYVCFKCKHKVSAEAET
(227) DNA topoisomerase [Nitrosomonas europaea ATCC 19718]
5
MSKKLIIAEKPSVASDIARALGGFVKQKDYFESDEFVVSSAIGHLLELIVPEEYEVKRGKWSFDHLPVIPPRFDLAPIEKTTDRLKLLSKLIKRKDVDMLINACDAGREGELIFRYIVRHVGSKKPIKRLWLQSMTPSAIREAFANLLNDAEVQSLADAAVSRSEADWLVGINGTRVMTAFNSQEGGFHKTTVGRVQTPTLAILVEREEAIKKFVVRDYWEVHATFQAESGVYKGKWFDEGFSKRKDESESRADRIWDHAKAEVIRDKCAGRTGVVTEESKPSRENCPLLYDLTSLQRDANSRFGFSAKVTLGLAQALYEKHKVLTYPRTDSRALPEDYPAIVKDTLQVLKGSRYDRFASQILESDWVKPNKRIFNNAKVSDHFAIIPTALVPKKLNEAEEKLYDLVTKRFLAIFYPAAEFLITTRITRVENEPFKTEGKVLVHAGWQTVYGKVESAQGQEEESVLVAVTPGETVLAQEVAVVAGKTRPPARYNESTLLSAMEGAGKLVEDEELRAAMSAKGLGTPATRAAIIEGLIHENYVERSGRELQPTAKAFSLVTLLRGLKIPELISPELTGDWEFKLRQIEQGQLKRDVFMEKIAAMTRHIVEQAKNHRDKTISGDFATLQVPCPGCGGVIKETYKKFQCQQCDFALWKILAGRQFEAAEMETLISTREIGPLSGFRSKMGRAFNAIVRLTDDYEMKFDFGNEADQAQEKVDFSAQQPLGKCPQCGHSVYEHKLLYVCEKSVGAGAPCSFRTGKIILNRAIEAEQVVKLLQTGRTDLLAGFVSRKGRPFSAYLVVGPAGKIGFEFEQKKTKSKPADTVPETGKAAS
(1851) DNA topoisomerase [Nitrosomonas eutropha C91]
5
MSKKLIIAEKPSVANDIARVLGGFTKQGDYFESDEYVLSSAIGHLLELIVPEEYEVKRGKWSFDHLPVIPPRFDLAPIEKTMDRLKLLSKLIKRKDVDVLINACDAGREGELIFRYIVRHTGSKKPIKRLWLQSMTPVAIREAFTNLLEDSEVQPLADAAVSRSEADWLVGINGTRVMTAFNSQEGGFHKTTVGRVQTPTLAILVEREEAIKKFVARDYWEIHAVFQAENGSYKAKWFDESFSKRKDESESRADRIWDHARAEAIRDKCDGRTGIVSEESKPTRENCPLLYDLTSLQREANSRFGFSAKTTLGLAQALYEKHKVLTYPRTDSRALPEDYSETVKDTLQALKESHYDQFASQILKSDWVKPNKRIFNNAKVSDHFAIIPTALVPKKLNEAEEKLYDLVTKRFLAIFYPAAEFLVTTRITRVEDEPFKTEGKVLVHAGWQTVYGKVESVRGQEEESVLVAVTPGETVLAQEVTAVANQTHPPARYNESTLLSAMEGAGKLVEDEELRAAMSTKGLGTPATRAAIIEGLIHENYVERSGRELQPTAKAFSLVTLLRGIKVSELISPELTGDWEFKLRQIEQGQLKRDVFMEKIATMTRHIVEQAKNHRGKTISGDFATLQVPCPKCSGVIKETYKKFQCQQCDFALWKILAGRQFEVNEMETLISTREVGPLSGFRSKMGRAFNALVRLTDDHEMKFDFGNEATQTEEEVDFSAQQVLGKCPQCGHSVYEHKLFYVCEKAVGPSPSCSFRTGKIILNRAIDTEQVIKLLQTGRTDLLTGFISKKGRPFSAYLVVGPEGKIGFEFEQKKVKSKRADAVPETGKAAS
(562) DNA topoisomerase [Nitrosomonas eutropha C91]
4
MRLFLCEKPSQGKDIGKVLGATQRDNGCLKGPGVIVTWCIGHLVEAAPPEAYDANLKHWSIEQLPIIPERWRIEVKPKTAAQFKVVKQLLAQATELVIATDADREGEMIAREIVELCGYRGPIQRLWLSALNDASIRKALAALKPSSETLPMYHSALARSRADWLVGMNLSRLFTLLGRQAGYDGVLSVGRVQTPTLKLVVDRDREINQFVSIPFWAIDVALSATGQSFIAQWLAPEACTDEAGRCLQESVAQQAAQQLRANGTAQVASVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMQADVPAVLDSLLRTDPALRPVMEQLDRRQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTIARLSCAGQHLQAVGKQIVIPGWRLVLVEQQAEDADDEAAPRSQVLPALNQGLSCQMNTVDLKALKTLPPRPYTQGELVKAMKSVAKLVSDPRLKQKLKDTVGIGTEATRANIINGLLTRGYLIKKGRAIRASEAAGTLIDTVPAAIADPGTTAVWEQALDMIEAGELTHDVFTGKQSAWISQIIAQYQGTAMTIKVPQGPACPQCGSATRQRTGKNGPFWSCSRYPECKGTVPVDSATPKRSAPRKRRSASKTS
(1839) DNA topoisomerase [Bordetella parapertussis 12822]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESDRYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIVQFAGVKKPIQRLWLQSMTQQAIRDAFANLRDDEQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNERENRIRSFVSRDYWEVHATFVAAAGLYEGRWIDPAFKKDERDPEKRESRLWSLAAAQSVVAACRAQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYINTVRQTMQVLAQGDSNAVGALSRHADTVLAQNWVKPNRRIFDNKKVSDHFAIIPTLQVPRDLSEAEGKLYDLVLKRFLAVFFPAAEYRVTTRLTEVQGHRFKTEGKVLVTPGWLAVYGKEAQGEDANLVPVADGETVRAEDVEAVGLATKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEAYLRRDGRDLVPTAKARQLMTLLSGLDVSELTSPELTGEWEHKLKQIEQGALDRAAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRFACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISGEYKLEFDFGQNDEEDNEAVDFSGHTSVGACPKCSARVFEHGMSYVCEKSVGPQKSCDFRSGKVILQQEISREQMEKLLTAGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRGDKPGRPGAAAKKAAGKTATKTAAKAPAKTAAKKAVKKAAPKKAATKTAARKTAKKSAA
(1427) DNA topoisomerase 1 [Ehrlichia chaffeensis str. Arkansas]
1
MSLIIVESPSKAKTISKYLGSKYKVVASFGHIRDFPAKSGSVDPDKDFAMTYEIISKSEKYVNKLIQVANKETQGIYLATDPDREGEAIAWHIIEVLKENNAIDDNVVINRMVFNEVTKSAILESIKRPRSINMDLVYAQQARRALDYLVGFTLSPLLWRKLPGSKSAGRVQSVALRLICDRESDIEKFITQEYWDIEAKCCNTEGKQFSAFLSCYAGKKLEKFDIKNEEDAQKLSEEVRSRSYSVINVEKKHTKRNPYPPFITSSLQQEASTKLGFTAKNTMLIAQKLYEGIDVGGEIVGLITYMRTDGFYIADEALEHIRSIIVSMFGKEYLPESARKYVKKVKNAQEAHEAIRPTNITITPGSLSNYLTPEQLKLYDLIWKRTVASQMNSAVIDQVIVELGSLDKVVTLRATGSSLFFDGFYKVYGHGEDDDSKNNMLPLLQKNDKCPLDEVVPHQHFTNPPARYNEASLVKKMEEIGIGRPSTYASIISVLQDRQYVILNQKRFFPTERGRIVNVFLVNFFSRYVEYDFTADLEEKLDLISNGKINWKEVLHQFWFLFIDNVNSVKKLEFTEVLKVISCEMENYIFSSDKSESSRVCPVCNDGTLELNISKNGIFLGCSKYPECKYTKNVGSGIVDDTDNTQYPKILGIDAATGQEIYLKKGPYGLYLQIGNDKSGKRAAIPKNIDANLLDLQMAEKILSLPISLGTHPDTGQEIKLGLGKFGAYILYGGKYFSVKNEHNFLDISIENAINIIANNSTSGVIKSLGITEDNKEVFLCKGRYGFYLKYDKLNVALKKDTDIEQISLSDAIKLISEKL
(1085) DNA topoisomerase 1 [Dinoroseobacter shibae DFL 12 = DSM 16493]
1
MPVVVVESPAKAKTINKYLGSDFTVLASYGHVRDLPPKDGSVDPEHGFEMLWEIASDSRKHVKAIADALKDDDTLILATDPDREGEAISWHLQEALTKRKAIKKSTDVSRVVFNAITKSAVTEAMKNPRDVDMELVEAYLARRALDYLVGFNLSPVLWRKLPGAKSAGRVQSVCLRLIVEREMEIEAFDPREYWSVRAVLETPRGQTYEARLTELAGKKLDKFDLATAEAAELAVQAVTSRKLSVTSVEAKPGTRNPSAPFMTSTLQQEASRKFGFGARQTMSTAQRLYEAGYITYMRTDGIDMAPEAVTMARDAIKERFGAAYLPDSPRIYKNKAKNAQEAHECIRPTEMSRAPEDLKVTEPDQRKLYDLIWKRTLASQMAAARLERTTVEIGSPDGQVALRATGQVVVFDGFMKVYTEGQDEESTAEDERRLPQIGQGDPAPLHKGGMEAAFAKAGSREDDVVEAAPTGGMQQGPGGLLSENGAVFGQQHFTQPPPRYTEATLVKRMEELGIGRPSTYASIVTTIQDRGYVTKDKNRLIPEDKGRLVTAFLVNYFRKYVGYDFTADLENQLDEVSAGDRNYKDVLDRFWRDFSAAIAETSELRITEVLEKINEVLAPHLFPPREDGKPPRLCPNCEIGQLSMRTARSGGAFIGCSNYPECRYTRPFGPPGMEEASGIPPEGKLLGEDGGDEIRVFKGRFGPYVQRGAVTEENKKPPRQSIPKSWVPEELELDKAVMLLSLPRQIGLHPDDGVPVWANIGRYGPYLKHADSTSDRGGTNANLEDIEEVWTVGMNRAVQLLAEKVASRGGRGAAAKPLRELGEHPEAGGPVNIMKGKYGPYVKWEKINATIPKETDPEQVTMEMAVQLIEERAAKSGKKAPAKKKAATKKKTAAKKTSAK
(1692) DNA topoisomerase [Bordetella petrii DSM 12804]
5
MSKTLIIAEKPSVALDISRALGGFAREGDYFESERYVLASSIGHLLGLVAPNDPVKGKWSFAHLPVIPPEFALGPADKRSAERLKLLVKLAKRKDVDALINACDAGREGELIFRYIIQYAGVKKPIKRLWLQSMTQAAIREAFSNLRDDAQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVFEREERIRAFVPRDYWEVHATFVAAAGLYQGRWIDPDFKKDERDPEKRESRLWSQAAAQSVVAACREQPGSVTEESKPSTQMSPALYDLTSLQRDANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYLGTVRDTMQALAKGGSNAVGQLSRHADTIVAQSWVKPNRRIFDNKKVSDHFAIIPTLQIPHDLSEAEAKLYDLVLKRFLAVFFPAAEYRVTTRITEVQGHRFKTDGKVLVAPGWLAVYGKEAQGEDANLVPVADNETVRTEDVEAVGLSTKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAGIIEGLLGEGYLRREGRDLVPTAKARQLMTLLSGLDVTELTSPELTGEWEHKLKQIEQGGLDREAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRYACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISDEYKLEFDFGQNDDDDSEPVDFSGHTPVGACPKCSSRVFEHGLSYVCEKSVGPDKTCDFRSGKIILQQEISREQMHKLLTDGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRAAKTGRAPAKTASKTATKTATKTATKAASKTAAKKAAPRKTAAKKAPAKKSA
(1410) DNA topoisomerase [Bordetella petrii DSM 12804]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFESVPYWAIDVSLSAGGQTFTAQWVAPDASTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRPIMEQLDRSVRSRAWNDTKVSAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTVAELFCGQQKLVATGKQVVAKGWRLVLAEPQADEDGDGAARSQVLPALRDGMACQIAGADIKALKTMPPKPYTQGELVKAMKGVARFVTDPRLKQKLKDTTGIGTEATRANIISGLIARGYIVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEGGQLTLDVFIGKQAAWISQLIAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPDCKGTLPVATGTSRRGASRPRRTSGGGRKGS
(1516) DNA topoisomerase [Bordetella petrii DSM 12804]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQLKRWSIEQLPIIPQNWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSASGQSFTAQWVPPDAYTDDTGRCLQQPVAQRAAQQIRGAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVSTVLDSLLRTDPSLRPIMDQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTVANLACGQQKLAATGKQVVVKGWPLVLTEPQPDEDGDAAARSQVLPALREGLACLVADVDLKALKTLPPRPYTQGELVKSMKGVAKLVTDPRLKQKFRDTVGIGTEATRANIISGLIARGYIVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYSIASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRGASRPHRSGRQGS
(1826) DNA topoisomerase [Bordetella petrii DSM 12804]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLSGSGVTITWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSAPFWAIDVSLSTEGQAFSAQWVAPDGCTDDAGRCLQQPVAQQAALQIRVADNTQVVSVETERVREGPPLLFDLSTLQEVCSKQLGLDVQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPAVLDSLLKTDPSLRPIMSQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSPLSEKELAVYRLIRAHYLAQFLPHHEFDRTVAEFSCGQQMLVATGKQVVVKGWRLVLAEPQADEDGDDAARSQVLPPLRGGLACQVAEVEIKALKTMPPKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQLIAQYGSMSLSIKLPHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTPKRGASRSRSSGRKGA
(780) DNA topoisomerase 3 [Gallibacterium anatis UMN179]
10
MRLFIAEKPSLARAIADVLPKPHHRNDGFIRCGENDYVTWCVGHLLELAEPDAYNPAFKQWRLEHLPIIPQQWQFLAKKSTAKQLAVIKQLLKQADVIVHTGDPDREGQLLVDELFAYFKLPKEKIATIQRCLVNDLNSAAVSKAVNKLQPNQDFKFLTISALARTRADWLYGINMTRAYTLRGQQVGYQGVLSVGRVQTPVLGLIVRRDLEIEHFVPKDFFEVQAIIHHSVETVADNPQLKGYPFKALWKPSEACEPYQDEEGRVLSKALAEHVVKRISEKSALVTEYQSKTEKEMAPLPYSLSALQIDAARMYGMSAQQVLDICQRLYETHKAITYPRSDCRYLPEEHFAEREKIFSAISNNCQQYQSFESGFNPAQKNRCWNDKQVEAHHAIIPTAKQGLRLNSEEQKIYQLVARQYLMQFYPDAEYHKTKIQLSIDNGTFIAQTRGLANAGWKKLQGKEDADPQSNISALPVVKKGDELYCSSAEVLNKKTQPPMYFTDATLLSAMTGISRFVQDKALKKVLRETDGLGTEATRAGIIELLFKRGFLTKKGRQIHSTEAGRILIGALPEIATQPDMTAHWEQQLEQIYRKGLSYQAFMQQLTAQLPQLIQQIDLQKLMSLRNVPQQQHSKKRFTRRSSTASQN
(464) DNA topoisomerase 1 [Gallibacterium anatis UMN179]
9
MGKSLVIVESPAKAKTINKYLGNSYIVKSSVGHIRDLPTSGSGNGEKAKPVSTKGLSAEEKAKIKQKKERDALVKRMGIDPYHNWKANYQILPDKEKVVSELKSLAKKSDHIYLATDLDREGEAIAWHLREVIGGEDERFSRVVFNEITKNAITQAFSHPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWQIAVETKNAEQQLLPFEVTHYQSKPLQIKDKQSADKATETLKNSRYIVTEVETKPTQSRAKAPFITSTLQQTASTRLGFGVKKTMLLAQRLYEAGYITYMRTDSTNLSQDALTMARAYISDNFSAAYLPEKPNFYSSKENAQEAHEAIRPSDIQLKADDLQGMEKDAIRLYDLIWRQFLACQMTAANYDSTTVTATADDYTLKVKGRVLRFDGWTKVLPPLGKNAEDRVLPEVKKGEELTLLQVIPSQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVRTENRRFYAEKMGEIVTDRLNESFPDLMNYDFTANMEDVLDQIAAGKTDWKQQLNQFFADFSTKLSQAELDELEGGMKPNHLVETNIPCPSCGRPMAIRTASTGVFLGCTGYALPPKERCKTTINLIPEAELLNVLDDNSETKALMERKRCPKCGTAMDSYLIDAHRKLHICGNNPNCDGYVVEEGQFKIKGYDGPVVECDKCGADMHLKLGRFGKYMACTQCDNTRKILKNGEVAPPKEDPIPFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRPAKVSELAQYRDRLPEKLQYLADAPQQDPEGNPTVIRFSRKEKRQYVNSEKEGKATKWIADYIDGKWVARAK
(288) DNA topoisomerase [Gallibacterium anatis UMN179]
4
MKLILCEKPSQGRDIGKFIGATKRGEGYLSSPDQQTFVTWGIGHLVEQAEPQDYDESYKKWIFDNLPIIPDKWIMKVKKETAKQYKIVMGLIKKANHIVIATDPDREGEVIARELLDMANYKGKVQRLWLSALDDGSIRKALANLKSDAETKPLYAAGLARGRADWLVGMNLTRLFTLIAQKQGYQGVMSVGRVQSPTLAIVVQRDREIENFVSKPFYRLKVNLDGFCAYWQPTESVCDDEGRCIDYSVITQVQRQLSKTLKIDNIETKRKKEMPPLAFDLGTLQQTCSRLFGMGAAQVLKIAQSLYETHKATTYPRTDCGYLPESMIDEIPLVLKAVSESDPQVRNIVAKLDISLRSRVWNDSKITAHHGIIPTTQKVDLSKMSDDELKVYQLVRKHYFAQFLPLYEEDNTSVLLSGNEQTFVSKGKQVIKIGWKSLFQQDRNEDDEEQSLPSLRQGQSCNVVDSEVLTLKTTPPKHYTEGTLIAAMKNAARFVTDARLKQRLRETEGLGTEATRAEVIETLFKRGYLEKKRKEIVATSAGRSLIDGLPDIIKDPGMTALWEQALNDIASGKMLLQDFMAKQNQFISHVVKSMIGSGSVAIQVKAEKICPKCGAAMRRRKGKNGDFWGCSNYPTCTAIENIGSRKRVGKSR
(1551) DNA topoisomerase 1 [Ferrimonas balearica DSM 9799]
9
MGKSLVIVESPAKAKTINKYLGKDFVVKSSVGHIRDLPTSGGQAAEKAPPSKTPAEVRKMDPEAKAAYKRERDYQSLIGRMGIDPEHGWAANYQVLPGKEKVVKELQTLAEKADTVYLATDLDREGEAIAWHLQEVIGGDPERYRRVVFNEITKSAIQEAFSHPLHLDNAKVDAQQARRFLDRVVGFMVSPLLWKKLARGLSAGRVQSVAVRLVVEREREIRAFVPEEYWDLHADLSSASGDALRMQVARFNGEALKMVNQGDADKAVSALKEARYTISAREDKPSSSKPSAPFITSTLQQAASTRLGFGVKKTMTLAQRLYEAGHITYMRTDSTNLSKEAVESVRGYIGQEFGNQYLPSSPNLYGAKQGAQEAHEAIRPSDVNVKASTLSTMERDAQRLYELIWRQFVACQMVPAKYDSTTVTATAGSYELKAKGRIMVFDGWTRVQPPMGRKGDEDTMLPAVQVGDVLDLKALDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFFAEKMGEIVTDRLVENFTDLLNYHFTAEMEQTLDKIAQGKLEWKAVLDQFYSDFTEKLTQAELAPEEGGMRANQMVMTDIACPTCGRPMGIRTATTGVFLGCSGYALPPKERCKTTINLTPGEEAEAITSDDQEAAALVTKRRCSKCESTMDSYLIDETRKLHVCGNNPVCDGYEVETGSFKIKGYDGPIIECDRCGSDMELKNGRFGKYFACTDSKETGCKNTRKLLKNGEVAPPKEDPVQLPELPCEKSDAHFVLRDGAAGLFLAASTFPKSRETRAPKVEELKRFKDRISPKFYYLAEAPQADPEGNPAVVKFSRKTKEQYVASEVDGKPTGWIARFENSRWVEEQTKKSKAKK
(1626) DNA topoisomerase 3 [Ferrimonas balearica DSM 9799]
10
MRLYIAEKPSLGRAIAAVLPKPHRNGDGHIVVGNGDVVTWCIGHLLEQVEPEAYDARYQRWALSDLPIRVDNWQLKPRKGGAKQLQVIKKLLKQATDVVHAGDPDREGQLLVDEVLDYLKLDDARRHSARRLLISDLNPAAVTRALKGMKSNREFAPLSVSALARSRADWLYGMNLSRAYTLLGQQAGYRGVLSVGRVQTPVLGLVVRRDEAIANFVAKPFYQLDALIEHDSGVIRARWQPSEACQRWLDEEGRLLSRGLAENVASRIAGQPATVVTSEHKESSQAAPLPYSLSALQIDANKAFGMNAQEVLTLAQSLYEKHKVITYPRSDCRYLPKDHFAEAGAVTQAIARCLPELDGAVSGADLKRRSRAWNDSKVTAHHAIIPTPKAVAPHSLSGKEAKLYGLIARQYLMQFYPAAQYAESKLVFTIGSGHFVAKGKVLRQPGWRALLPKKPEAESRATLPELAPGSQWPCRGGEIKDCMTEPPKAFTEATLLQAMTGIARFVLDDTLKGILRETDGLGTEATRAGILELLCKRGLLRREGKTLRSTPSGQGLIHALPEQASYPDMTAHWERKLQDIAEREYGYAPFMADLDQRLLALVTQAQQGGVPPSLRNLPAVARKAPVRRRRKTAKKTPSQ
(367) DNA topoisomerase 1 [Campylobacter curvus 525.92]
1
MKDLIIVESPAKARTIKNFLSKNYDVIASKGHIRDLPKTSFGIKIEDDKFTPEYRVSLDHSKIVKEIKELAKGANEIYLATDEDREGEAIAFHIANAIGKEVSALPRIVFHEITKTAIDNALKHPRKIDMNSVNAQQARRLLDRIVGYKLSPLLNLKIQKGLSAGRVQSAALKIIVDREREIIAFKPVEYYSIDTKFKTDLDAELVKFEGKKIEKLTITNADRARYIVDALKNEKFSVREIESKDRKIQPSPPFMTSTLQQSASNRLGFSPKKTMMLAQTLYEGVQTHEGFMGAITYMRTDSLNLAKEAVEAARELIKNEFGKDYLPPKAVHYATSSKGAQEAHEAIRPTNLNFTPEIAAKFLQKDELRLYTLIYNRFLACQMSACVSQTQNLFVVSDNGEFKISGRKVLFDGFYRVYGDMDKDKILPNLNVGDEMKLESIKESQHFTEPPARYSEAGLVKKLESLGIGRPSTYAPTISLLTSREYVRVEKKQLIPNDVAFSMIGVLEEHFNDIVDSEFTSHLEEKLDLIAEDKADWQKVLSEFYYPFMDKISEGKTGIKSLKVATPIGEKCPQCGGELVKRKGRYGEFIACSNFPKCKYSRNIASQANDAGAQTTEPKAKKELVKLDVPCPKCGGVIVERFSRRGKFYGCANYPKCDFISNYEPTEHKCSECGSMMVKKELKKGTFLECTKCKHKVQIGEN
(1055) DNA topoisomerase 1 [Methylobacterium extorquens AM1]
1
MKVVVVESPAKAKTINKYLGRDYEVLASFGHIRDLPAKDGSVDPEADFAMIWEVEDRGAKRVSEIARAVKGAEKLILATDPDREGEAISWHVIEALTARKALKGIPVERVTFNAITKASVDAAMKKPRQIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWSIIATLVTEAGGVFEARLVGADGKRIQRLDVGNAEEAAAFKRDLELATFQVASIEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDVGGETVGIITYMRTDGVDMAPEAIQDARQVIGREFGDAYVPSAPRKYTVKAKNAQEAHEAVRPTDMGRLPKHVARHLEPEQAKLYDLIWTRTIASQMESAELERTTVEVSANVGPRRIDLRATGQVVKFDGFLALYQEGKDDEEDEDAKRLPAMKAGDALKRERIASTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVRIEKKRLQPEDKGRLVTGFLESFFKRYVEYDFTASLEEQLDRVSNAEIDWRSVLRDFWRDFSAAIGGTKELRVAEVLEALNGLLGPHIFPEKADGGDPRACPTCGAGQLSLKLGKFGAFIGCSNYPECKYTRQLSASGVEGEGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFVQLGEASAEKGAEKPKRSSLPKGTTPGSVTLEIALRLLSLPREVAKHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRPSSDPGRTLGQHPDGAALVVKAGKYGPYVSDGSVNATLPKTMAAESLTLEQAIDLVNAKRASGGGKKPVRKTASRARAPAKKAEAGEAKKPAVRKTAAKPAAKATATKAAAKPAAAKKATAKTKAG
(531) DNA topoisomerase [Methylobacterium extorquens AM1]
3
MPQRLFIAEKPALGRAIATALATLSGARPSAGRGFIEVGGDCVTWTIGHAYDTAEPGDYSSTWDKWSLDVLPMLPERWKLVPNAEIADQIAVLKDRIRRYDHFVNVGDAEREGQLIVDEILIENGVDPFSPKVSRVWVSSFVEKDVAAAVAGAFPNSQKKSLYEAAVARQRADWLLGMNMSRVFGLMVQQSGARGFRVSVGRVQTPTLKLVVDRDWQIENFKAVDHFAPSITFVHENGTFKAAWQFPADTKGLDPEGRLLDKAVAQALVQKIAGKTGTVESYSETPKSTSPPLPFALSTLQKACSQKFGLTAQQTLDVAQELYEKHKAITYPRSDSQHLPNSVHTDEADGILRNLAGVRELADAAGRANPKLKSPAFDDKKVTDHHGIIPTSEASASKLAAMGEIERKVFLLIARTFVAQFHPDFRYVSSAATVLCEGERFKATGTRVVDQGWKTVFGAEEADEEEEAEGTLPSMKMKDPVDAKAGSIDPKRTKPPAHFDDGTLVEAMAKIHLYVQDQEVRKRLRENDGIGTEATRASMIEKLIRAKYLERRTKGKRKILVSTDAGRQLVDLLPSDLVAPDTTAMWESFLERVKGGEFTLAQFMDRQTQFVRKRVQTAIAAGAIQVKGFSVEPLEGHGTECPHCRAGHLVTQLWPFDDEYKGRRFLRCDNWVKDRADNCRYKTPPEGYKEREKLEGEGNPCPACGKGVLKGGVVRKEGPNRGRPFLMCSEVDREKPDSCQHFEWKDETPCPSCGKGVLKRGVVRKEGPNKGRPFAMCSAVDRTNPDGCQHFSWLDEKAAKGPKIKGEGELCTVCGKGTMMRRTGRTSGKPFLSCSNWKQGASDSCDNRVFPDDGGRRPAGGASAAPAARPRGGRPSPGGGKRSFAKAR
(883) Putative DNA topoisomerase [Methylobacterium extorquens AM1]
3
MADLFVIEAPFKAQLLEGILRELHVDAKVQATRGHFMSMPGKLRPLGIDCRMREFMRVPANPEVFMRLRDMARSADNLYIATDADQEGDVIAWDVYEAVRDIHPSPARVRLKSMDHASIREAIAAAGPVEKAAAVPGRARGIIDRMIGGVFGSPEVPAGRVSTAILGLVASRGLSVTKVRLAAPSKDRGRPWLAEFDLAAPLDLPTAERLAKLDLPPLGSRGSPVVHPTKPSHTGDILVRAGDRLDISPAEAAASLQRSYEAGRMSYPRAGSRGMTPETAKQIAGIFRKSGWTAVKTENFAAKGEDETHEAPHPIGAVDPRLNPGRLGQDEGVRTLVAADLVKAGMEHKRETAFAQDLAPFLRAQGLPGEVADFVAGLRPGRDGATLTWHREHGPAYPGQEVWARSGIERRRPDTVLLEAVVKAGLGRPSTWPRHVQTFMDRGLADDDLKLTPRGRAWVEGSYAPLLDPRLSAAIEVACERVDPSLFDDPDREPWEVMVDQIVNLLPPSVRDPLREAVAHEPPRQKIDWVGKLDARPDLVGRLAQYVSRPEYAPDL
(1684) DNA topoisomerase 1 [Sulfurospirillum deleyianum DSM 6946]
1
MEKSLKNLIIVESPTKAKTIKNFLGKNYTVVASKGHIRDLPKSSFGIKIDNQTFIPEYRVPKDHASVVKEIKELAKEADQVYIATDEDREGEAIGFHIATAIGKDPKSLPRIVFHEITKNAITHALENPRILDESSINAQQARRLLDRIVGYKLSPLLSSKIQKGLSAGRVQSSTLKIVVDREKEIRAFKEEEFWSIDALFNKTIEASLVEFEGEKIEKMSIGNQERAYAIKEKLLKEAFHVALLEKKERESSPSPAFMTSTLQQSASSALGYSPKKTMMLAQTLYEGVKTHQGVQGVITYMRTDSLNVSKEAIEAAREQILSQYGKTYLPEKARFYANKSKGAQEAHEAIRPTILEFTPAIASAYLAPDELKLYALIYNRFLASQMNNARFESQTLIFESQSGKFKASGRKLLFDGFYKVYGDNDKDKLLPDLALKQEVTLSKLDANQHFTEPPSRYSEASLIKKLESLGIGRPSTYAPTISVLSARDYINIEKKQIVPTEVAFQVTELLEQHFPQIVDSSFTSTMEERLDLIAEDKEDWQAILWNFYEPFDAQVAKGKTEIQSQKVIVFTGEMCPECGKELVRRKGRFGEFIACSTYPTCKYTQNLKKVSESAPKEKVTLSVPCPECGGEIIERSSRRGKFFGCGNYPKCKFISNYEPTDKKCPECGYIMAKRELRKKEIYECIKCKHKEEA
(15) DNA topoisomerase 3 [Dickeya zeae Ech1591]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGDQDTVTWCVGHLLEQAQPDAYDARYARWSLTDLPIVPQKWLLQPRPSVSKQLNVIKKLLTQADEIIHAGDPDREGQLLVDEVLEYLALSEEKRQHVRRCLINDLNPQAVERAVSRLRENREFVPLCVSALARSRADWLYGINMTRAYTLLGKNAGYEGVLSVGRVQTPVLGLVVRRDEEIDNFVPRDYFEVKAHIVTPANERFVALWQPSESCEPYQDDEGRLLHRPLAEHVVKRIEGQPAWVTAYNDKRESETAPLPYSLSALQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRQAVLNAIATHRPDLLPQPAVDPERRNRCWDDGKVDAHHAIIPTARSARTSLTEQESQVYGLVARQYLMQFCADAVFRKCVIDLDIAGGKFVAKARFLAEAGWRTLLGNKERDEENEGMPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKALKKILRETDGLGTEATRAGIIELLFKRAFLIKKGRYIHSTDAGKALIHALPPIAAHPDMTAHWEATLTQISEKRCRYQDFMQPLTQSLYELIQQARQSGNIQAFRGLPAVKRATPEKRKRRQSRSASTKE
(1778) DNA topoisomerase 1 [Dickeya zeae Ech1591]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSGSASKKSAEANGEKAKKAVKKDERTALVNRMGVDPYRGWQAHYEILPGKEKVVSELKMLAQNADHVYLATDLDREGEAIAWHLREIIGGDEKRFSRVVFNEITKNAIRQAFENPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELHADLLANAETALQMQVTHHHGKPFRPVNQAQTQAAVSLLEKASYVVNEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMARDYIQGEFGKRYLPDAPNLYTSKENSQEAHEAIRPSDVSVLADQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLVVSAADYQLRAKGRTLRFDGWTKVMPALRKSDEDRTLPAVEIGQSLSLEKLSPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMENSLDLVANSQAEWKAVLDEFFAEFSQQLETAEQEPDEGGMKPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLIPEAEVLNVLEGDEAETNALRARRRCSKCGTAMDSYLIDNQRKLHVCGNNPSCDGYEIEQGEFRLKGYDGPVVECEKCGSEMHLKMGRFGKYMACTSDSCGNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFRDRLPEKLRYLADAPVTDPQGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYVDNKWVETAR
(1586) DNA topoisomerase [Dickeya zeae Ech1591]
4
MRLFLCEKPSQGKDIGRVLGTTQRGNGCLTGSGITVTWCIGHLVEAAPPETYGEQYKRWSIEQLPIIPECWRVEVKSKTASQFNVVKELLSKATELVIATDADREGELIAREIIELCGYRGPIQRLWLSALNDTSIRKALSVLRPSDETLPMYFSALARSRADWLIGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWAVEVVLSSAGQHFTAAWLAPDTAADNAGRCLQEPIARQATERMRVTGSAQVTSVETEHMREGPPLPFDLGTLQEVCSRQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPIVFDSLLKTDPDLRPIVDLLDRNQRSRAWNDSKVTAHHGIIPTLEPANLAAMSDKERAVYTLIRTHYLAQFLPHHEFDHTTAYLSCAGEMLQAVGKQVVLVGWRRVLTEPKPDDDGDTTSRSQVLPPLNEGLSCQITGIDCKALKTSPPRPYTQGELVKSMKSVAKLVSDPRLKQTLKDTTGIGTEATRANIIKGLLDRGYLLKKGRSVRASDAAFTLIDAVPGAIADPGMTAIWEQALDMIESGQLTLDVFIDKQSAWIAQLIQQYRGASLSIQMPLGPACPECGTPMHQRPGKNGAFWSCPRYPDCRGSLPIDSGKRKRTTPRKRNSSLQAS
(1641) DNA topoisomerase 3 [Shigella dysenteriae Sd197]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRYLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSGFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKARIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGRKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIV
(1216) DNA topoisomerase 1 [Shigella dysenteriae Sd197]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSYFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPENLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(447) DNA topoisomerase 1 [Rickettsia massiliae MTU5]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQTLEKFSIINEKNAKDLIEKLKSQKFHVDKIEKKQQKRQPQPPFITSSLQQDAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMNLVVANLASENKEYLAKANGSTIAFDGFYKVYRESVDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCTSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHKDSDEEIMVGYGKFGPYIKYMGKFIAVQKKYDFLNLSLDDAMKLIEENKEKLEKKQA
(1576) DNA topoisomerase [Burkholderia pseudomallei K96243]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDMDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDHLGTVTEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKGEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIAEVEELLRKKEIGPLSGFRSKMGRPFSAILKLTFDDETKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQPDGKIGFEFEKKEPKPAAAKKTAARSSAAADDAAADSGEKAEKKAAPARKTAARKTPARKTGS
(1138) DNA topoisomerase [Desulfobacterium autotrophicum HRM2]
7
MTELILTEKFSVASDFAKALGVKNKKDGYFEGDAHVITWAVGHLVELFEPDDYDAGLKKWRVETLPLIPERFRYKPITRTLQQFRTIKALLTQRQFDRIIIATDAGREGEVIARTILLESGFRDKERIMRFWTSQALVPKVVRDTMNQLKPITDYDRLWRAGYYRQVSDWLVGMNLTRLMTVRLGDLFSVGRVQTAVLAMLVDRRNEREHFIPETYWNFKVLFSGDKGRWTGRWFKEKETRITDKPQADALLERFQAEKAPGVVVSMKKETKQEPPPLLFSLTDLQQEANNRFGFPAKKTLAIAQALYQDRKCLSYPRTDSKVLGTASLGLVNTVLGKLEQACPDLFAFVDPKRVSLSNRRVFNDAKLTDHHALIPFKPISEAASRDEKLLFDLVVRRFAAAFHPDCRFESTRVVTLFAKETFQTRGKVILDPGWQRVYGTGIRDKAEAEIIPPLVEGDEGAVEKIEREEKQTSPPPDYSDSLLLKDMTNPGRYVAEEEIKRLYRGDIGIGTQSTRAQIIETLISRGYVQRAGKRLLATDKGGYLVTQLRKCPISSVLTSPEETARWEMQLNTIALGEGSDIRFLDHIKAFVTNAVAELKSAGLNVKLFKAEQPQAAVIGICPACGKAVRENPKAFSCEDRGCEFVIFKRIAGKSISAKMATNLLQYRKSGPFKGFISKKKKRFSASLKIVNENGHWKVTFDFNNQGKASSNNGQASPDPRRSISTVERVRSEPRGPESLSAPGSEPTQGAETMRCPLCNGTIIEGNRGFGCSNWRPEHGDCRFVIWKEIAGKTLTLQNLETLIAGKKTRPYVLKNSNGDKFKASMKMVKAPGQGVAIEVEPQGEGQGFKVLCLR
(306) DNA topoisomerase 1 [Desulfobacterium autotrophicum HRM2]
1
MKKPLLIVESPTKVKTLKKYVGKDYNVTATVGHIRDLPPKELGIDIEDDFKPKYITIQGKTKVIQAMKSAAGDTDTVYLAPDPDREGEAIAFHAAEVLKKKGRTFYRVLFHELTQKGISEALENPLDLNHDRYEAQQTRRSLDRLVGYQISPLLWRRVQGGLSAGRVQSVAVRIICDRERIIRAFEPEEYWTITADLATDLPPTFTAALARIDNKKAVIPDQQTAEKIVGELENAAFVVEKIVSRTIKRNPLPPFITSKLQQDAINRLRFTAKKTMLVAQQLYEGIEIGTGGPEGLITYMRTDSIRIADEAAQEALEHIRQTFGPEYALATPRFFKNKNKAQDAHEAIRPTSVLNTPERLKSFLGEDQFKLYELIWNRFVASQMAQAIIDQNTISIQALNYTFTVGGTTVKFPGFMALYAAIDEKADKAKQKLPIIEQGMGLERKAIIPKQHFTKPPPRFSEASLVKELEENGIGRPSTYASILSIIRDKGYVELINRYFVPSELGFIVNDLLMTSFPEILDTDFTARMENDLDEIESGTKHSLGVLKAFYSTFKEKLDHAKENMLSVKGVGIPTGLSCPLCGKPLNIKMGRNGHFIACTGYPECSFSSNYTRDEKGAIQILETKTDNTKVKDCIKCGSPMVKKEGRFGEFLACTGYPECKHTESVNGDAGGRETGAKCPEPLCNGVIVEKRSRRGKTFFGCNKYPECTFASWDPVVNKPCPKCNSSYLIEKQTKKEGKFLKCPNKECTYKESLDD
(1142) DNA topoisomerase 1 [Agrobacterium radiobacter K84]
1
MMNVVVVESPAKAKTINKYLGPGYTVLASFGHVRDLPAKDGSVLPDQDFEMLWEVDPASQKRMKDIADAVKSSDGLFLATDPDREGEAISWHVLDLLNKKRVINGKPVKRVVFNAITKKAVLDAMADPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFISEEYWNLSAILKTPRGDEFEARLVAANGKRLQPRAIGNGEEAGNLKALLEGASYVVDTVEAKPVKRNPSPPFTTSTLQQAASSKLGFSASRTMQVAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIDAARTAIADQFGNRYLPEKARLYSTKAKNAQEAHEAIRPTDFDRTPDRVRKYLDADQLRLYDLVWKRGIASQMASAEIERTTVEILADNGGQKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDADDEDGRLPEINARENLAKQKINSTQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLATLRDRDYVTIDKRKLLPQAKGRLVTAFLESFFTKYVEYDFTADLEEKLDRISAGELNWKDVLRDFWRDFFAQIEDTKELRVTNVLDALNEALAPLVFPKREDGSDPRICQVCGTGNLSLKLGKYGAFVGCSNYPECNYTRQLSSEGGTEAEASGLNEPKALGTDPVTNEELTLRSGRFGPYIQRGDGKEAKRASLPKGWKPEDIDYEKAMALISLPRDIGKHPESGKMISSGIGRYGPFLLHDGSYANLETVEDVFTVGLNRAVTVLAEKQSKAGGGRGTPAALKDLGAHPDGGGSITVRDGKYGPYVNWGKVNATLPKGSDPQAITVEEALALIVAKAGKSGGGKPARAPAKAKTKTAAAASKTTKTTAKPKAKAATKAKTTKKSAE
(1428) DNA topoisomerase 1 [Rhodobacter sphaeroides 2.4.1]
1
MAVVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPPKDGSVDPEHEFAMTWEVAADSKKHVRAIADALKTDDTLILATDPDREGEAISWHLQEALASSLKKGKTVRRVTFNAITKSAVTEAMKAPREVDTALVEAYLARRALDYLVGFTLSPVLWRKLPGAKSAGRVQSVCLRLIVEREMEIEAFRAREFWTVSAVLATPRGQEFEARLTVLGGKKLEKFDLATSEAAELAVQAVTSRPLKVASVEAKPASRNPSAPFMTSTLQQEASRKFGMGAKQCMSAAQRLYEAGHITYMRTDGIDMAPEAVMAARDEIKRRFGANYVPDSPRMYKNKAKNAQEAHECIRPTDMSASPEKLGLTDTDQRKLYELIWKRTLASQMAAARLERTTVEIASPDGQVGLRATGQVVLFDGFLKVYEEGRDDRSDGDEDDEGRLPQIMANEAVEKKSITPEQHHTQPPPRYTEATLVKRMEELGIGRPSTYASIVSTIQDREYVRKDKNRLIPEDKGRLVTAFLANFFRKYVEYDFTADLEGELDDVSAGERNYKEVLARFWRDFSAAVAETADLRIGEVLDKLDEFLAPHLYPPRPDGSDPRICPTCGSGRLHLKTARGGGAFIGCGNYPDCRYTRPISVTGDEENAISPDGKLLGHDEDGAPISLRSGRFGPYVQKGEVTAEVPKPPRASLPKGWAPDTVDLDRALMLLNLPRLVGSHPEDGQPVEAAIGRYGPYVKHGSTYANLPDVEEVFTIGMNRAVEVLAQKAAGRRGASAPAQPIKELGEHPDGGLLAVMPGRYGPYVKWGKVNATIPKGIEPEAITLEEALALVAEKAGKAPKKKAPARKAKAEEGAPKKAAPKKAAAKTTKTAAKKPAAAKSTAKKKAAPDTDAA
(105) DNA topoisomerase 1 [Francisella philomiragia subsp. philomiragia ATCC 25017]
1
MAKNLVIVESPAKTKTIKKYLGNDFDILASFGHVREIPSKDTSIDVNDNFKIKFTTSERSKKHLDAIKKAAKSAENIYLATDPDREGEAISWHVQEVLKNAHLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVNAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLIEFNNTKVEQFTFIAEKDAKKAKSTIVKDANGFLIVEGVTEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIESKFDKDMLPSKPRVFDKKSQNAQEAHEAIRVTAANRTPESIKQHLTSDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHKFRVTGTVIVDAGFLKIYNVEKDEDEKDSDDEQTLPEFEKGEKVPLKDIITKAHSTEPPPRYTEASLVKALEKHGIGRPSTYATIISTLQQRDYVEVEKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIANHKNDYLSVLNSFWHPFIEKINKISEDVSRKDVVTEELDEDCPECGSKLSSRLGKNGRFIGCTNYPTCKYTRRVDSDGKEVEKEEPTVVEDRKCPECGSDLHIKQGRYGKFIGCSNYPTCKHMEPLEKPKDTGVVCPKCNKNNIVEKKSRKGKVFYACSGFPKCKNAYWYPPIKEDCPKCKSPILLHKTTKKDGEQKACPNPECDYAVPWEENN
(897) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Enteritidis str. P125109]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1734) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Enteritidis str. P125109]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(358) DNA topoisomerase 3 [Erwinia pyrifoliae Ep1/96]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGSDQVVTWCVGHLLEQAQPDSYNSRFARWSLDDLPIVPEKWRLQPRPSVAKQLNVIKGLLAQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKRAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVRAHIVTPADERFVALWQPSASCEPYQDEEGRLLHRPLAEHVVARIGGHPAHVTSYNDKRENETAPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINVHQPNLSPPGDFNSDQKNRCWDDKKVDAHHAIIPTARSSQVSLSDNEQQIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFVAKARFLAEAGWRALLGSKERDEENDGTPLPVVTKGDELLCERGEVQEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMSPLVDTLHSLIQQARQQPAAHAFRGLPAPATDKTKRPRRKTAQKKESET
(1770) DNA topoisomerase 1 [Erwinia pyrifoliae Ep1/96]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTVKKSADSTTSKTTKKVKKDEKTALVNRMGVDPFHGWEANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIRQAFDRPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVDREREIKAFVPEEYWELNADLTTPKGVDLPMQVTHQHDKPFRPINREQTYAAVSLLEKARYVVVDREDKPTGSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMVRGYVEEEFGAKYLPKTANLYSSKENSQEAHEAIRPSDVKVQSEQLKDMDADAQKLYQLIWRQFVACQMVPAQFDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDDRTLPAVEVGSELSLQQLLPGQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNEAQWKAVLDQFFGDFSQQLEQAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALSPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCGKCGTAMDSYLIDNQRKLHVCGNNPECDGYDIEQGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPQVEELQRFRDRLPEKLRYLADAPAKDADGNKAVVRFSRKTKQQYVSTEKDGKASGWSAFYVDGKWEVTKK
(787) DNA topoisomerase 3 [Pectobacterium wasabiae WPP163]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGQNDVVTWCVGHLLEQAQPDVYDARYARWSLADLPIIPQKWLLQPRPSVSKQLSAIKKLLNDASEVIHAGDPDREGQLLVDEVLEYLSLSEEKRQQVRRCLINDLNPQAVERAVSRLRENREFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVSKDYFEVKAHIVTPADERFVAIWQPSESCEPYQDEEGRLLHRSLADHVVKRIEGQPAFVTSYNDKRESEIAPLPYSLSTLQIEAAKRFGLSAQQVLDVCQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAISVHQPDLLPQPVMDVDRRNRCWDDGKVDAHHAIIPTARSASASLTENERKVYGLVARQYIMQFCPDAVFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGGKERDEENEGMPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRTFLFKKARYIHASEAGRALIHSLPDSAAHPDMTAHWEATLTQISEKKCRYQDFMQPLTNSLQELIQQAKQNGAVRAFKGLSAPPSGASKRRKPQAKKAKEQKQ
(1350) DNA topoisomerase 1 [Pectobacterium wasabiae WPP163]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSASKKSADSTTKDKTKKKVKKDEKSALVNRMGVDPYHGWKANYEILPGKEKVVSELKTLAENADHIYLATDLDREGEAIAWHLREIIGGDDRRFSRVVFNEITKNAITQAFEKPDTLNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVDREREIKAFVPEEYWELHADLLAGSDIQLQMQVTHHNGKPFKPVNKAQTHAAVSLLENARYIVADREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALTMVRGYIGEEFGKRYLPEAAIAYSSKENSQEAHEAIRPSDVGVLADSLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLIVEAADYQLRAKGRTLRFDGWTKVMPALRKNDEDRTLPTVAVGEALSLQKLLPGQHFTKPPARYSDASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESRLDQVANNQAEWKAVLDEFFNEFSQQLEKAEQDPEEGGMRPNAMVLTSIDCPTCSRQMGIRTASTGVFLGCSGYALSPKERCKTTINLIPETEVLNVLEGDEAETNALRARRRCEKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIETGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMSCTGETCSNTRKILRNGDVAPPKEDPVPLPELSCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPEVDKDGNKTQVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEGKK
(556) DNA topoisomerase [Pectobacterium wasabiae WPP163]
4
MCEKPSQGKDIGRVLGATQRGNGCLAGSGITVTWCIGHLVEAAPPETYGEQYKRWSIEQLPIIPERWRVEVKSKTASQFNVVKNLLSKATELVIATDADREGELIAREIIELCGYHGPIQRLWLSALNDASIRKALAALRPSGETLPMYFSALARSRADWLIGMNLSRLFTVMGRQAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWTVETVLSSAGQSFTAGWLAPDTATDDAGRCLQEPIARQAAERMRIAGSAQVTSVETERLREGPPLPFDLGTLQEICSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPVVLDSLLKTDPGLRPIVDQLDRNQRSRAWNDSKVTAHHGIIPTLEPANLTAMSDKEQAVYKLIRAHYLAQFLPQHEFDRTTACLSCTGETLQAVGKQIVVIGWRQVLTEPRPDEDGETTLRSQVLPALHEGLSCQITGIDCKALKTSPPRPYTQGELVKAMKGVAKLVSDPRLKQKLKDTTGIGTEATRANIIKGLLDRGYLLKKSRSVRASDAAFTLIDAVPGAIADPGMTAIWEQALDMIEAGQLTLDVFIDKQSAWITQLVQQYRGASLSIKVPQGPACPECGTAMRQRTGKSGPFWSCPRYPDCKGSQPIDSGKHKRAMPRKRSRSSREP
(551) DNA topoisomerase [Pectobacterium wasabiae WPP163]
4
MRLFICEKPSQARDIAAVLGATKRGQGFLSAPGITITWARGHLLETASPEVYGTQFEKPWRIDVLPVLPPVWQMVVKSESSDQFTVISRLLKQVDEVVISTDADREGEVIGWSLLEYCGWRGPVFRLWLSALDESSIRAALAAIKPGSETKPLYYAGLGRSRADWLIGMNLTRLYTVKARDKGYDGLLSVGRVQTPVLAMVVNREREIATFVPKPYWQVWVALQSNGVRFSAQWVPAKMYVDEEKRCIHQDIAQQVAQLCKQTGKATVIEQETKREKEAAPLAFTMGTLQQACGRLWDMSPQKVLDIAQSLYETHKATSYPRTDCGFLPESMREEIPDVLSALVKIDPSLQALISQLDTRFVSRIWDDKKMTAHHGIIPTRHVCDMSKMSDQEKQVYVLIRRHYLAQFFPLHEVDFTRLSLNIGGQLFQTTGRVVVVPGWKRLFSQDDGEHKEAAADEKDQSLPMLVKGDNCGVAGSEVKALKTKPPQYFTFQSLIAAMMNAAAYVTDLTLKKVLKENAGLGTEATRGGIVETLLARNFISIKGRYLRATDIAMDLIDALPHALKEPGMTALWEQALDEVAKGRMTLDSFMSRQTQWICQLVSLGTQQDVVVRVPPTPACPLCGSKTRLRKGAKGAFYGCEKYPDCKGMINVPGQSKNAASKTRKKKQN
(454) DNA topoisomerase 1 [Cellvibrio japonicus Ueda107]
9
MGKSLVIVESPAKAKTINKYLGSDFVVKSSIGHIRDLPTSGNNKPVDTKERARQAAATRKMSAEQKAVYQAQKSKSQLVGRMGIDPENHWEAHYEILPGKEKVVDELKKLAEKADAIYLATDLDREGEAIAWHLREAIGGDESRFRRVVFNEITKTAIQNAFKSPGPIDQNRVDAQQARRFLDRVVGYMVSPLLWEKVARGLSAGRVQSVAVRLVVEREREIRAFIPEEYWTLFADLKAESGQIASFEVKKQGEEAFKPINEAQAMAAVTALQHAAYKVVSREDKPTQSKPTAPFITSTLQQSASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQEAVESCRTYILDNFGQKYLPKEPVAYSSKEGAQEAHEAIRPSSVDVMPNQLSAMERDAERLYGLIWQQFVACQMTPAEYTSTSVVVEAGNYELRTRGRVIRFDGYTRVLPQQAKKDEDVVLPDMKVGQVLPLVKLNPQQHFTKPPARYTEASLVKELEKRAIGRPSTYAAIISTIQERGYVRQENRRFYAEKMGDIVTERLMESFDDLMDYGFTANMEEALDQVAQGDKNWRQLLDEFYADFSQQLDTASRQDKGMRANDPTDTNIPCSLCGRHMQIRTGSTGVFLGCSGYALPPKERCKNTMNLVSGHEVIDADADDEAESRQLRSKHRCKLCNSAMDSYLIDEQRKLHICGNNPDCPGYEVEQGVYRIKGYEGPTIECDKCGSEMQLKTGRFGKYFGCTNADCKNTRKLLKNGEAAPPKVEPIAMPELRCEKVDDHYVLRDGAAGLFLAASQFPKNRETRAPLVAELLPYKNQLDPKYHFLLSAPVSDPEGNKAIVRFSRKTKEQYVQTEVNGKATGWKAFYVNGRWQVQK
(355) DNA topoisomerase 1 [Pseudomonas fulva 12-X]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGGAATKEPAKRGKAAAGEAPALSPKEKAKRQLFARMGVDPEHGWKAKYEILPGKEKVVEELRRLAKEADTIYLATDLDREGEAIAWHLRESIGGDDSRYKRVVFNEITKKAIQEAFSAPGELDINRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREKEIRAFVPEEYWEVHADLGTAKDAQVRFEVVRENGAAFKPLNEAQAMAALATLKASSYSVAKREDKPTSSKPTAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAIEMVRGFIDKEYGKKYLPEKPNFYSSKEGAQEAHEAIRPSDVNLRPTQLSGMERDAERLYELIWRQFVACQMPPAEYLSTTVTVNAAQFELRAKGRILKFDGYTRAQPQLSKPGDDAMLPEMKESESLKLIKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTERLSESFSDLMDYGFTAGMEENLDDVAQGEREWKHLLDEFYGDFKKKLEVAADGDNGMRANTPTLTDIPCRECGRPMMIRTASTGVFLGCSGYALPPKERCKATINLVPGDEIAADDEGESESRVLLGKHRCPICATAMDAYLLDETRKLHICGNNPDCAGYEIEQGQFRIKGYEGPSLECDKCGSQMQLKTGRFGKFFGCTNSECKNTRKLLRNGEPAPPKMDAVKMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVLELLPHKDEIDPKYHFLFDAPAKDPEGRAAVIRYSRKTKEQYVQTEVDGKPTGWKAFFDGGKWKVEDKR
(315) DNA topoisomerase [Pseudomonas fulva 12-X]
4
MRLFLCEKPSQAKDIASVLGATRRGDGCWLGNGVTVTWCIGHLLETAPPDAYDARYKRWVLDDLPIVPQQWKMRVKANTAAQFKAIKRLLGEASELVIATDADREGEMIARELLEHCRYRGPIQRLWLSALDDASIRKALAALKPGASTYNLYQSALGRSRADWLIGMNMSRLFTLLGRKSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIDVTLDGNGIPFTAVWRAPQDDCDEQGRCLKQEVAQRAAEAMQGAEHAVLEKLKTERMREAPPLLFDLGTLQQVCSKKLGLGAQETLDIAQKLYETDKLITYPRSDCGYLPLSQHAEAPAILAALGQADPTLREVLAHTQTQRRSRAWNDAKVSAHHGIIPTLAAGGLTRLSGRPRAVYELIRARYLAQFLPNHEYDRTQADFDCAGHDLRAVGKQIVEPGWKRALPEALAPSKGREAPAPQALPALHEGQTCAVREVTLKDQFTQPPKPFTEGDLIQAMKNVARLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLTKQGKTLAATSAAFGLIDAVPRAIADPGTTAIWEQALDMVQSGEMPLDEFVAKQSAWMARQIERCRGLQLTISGPPPGGRPAWKGKRKGASRKKAASAKRAGASAAGGRSK
(156) DNA topoisomerase [Collimonas fungivorans Ter331]
5
MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDEYVLSSAVGHLLEIAVPEEYDVKRGKWTFTHLPMIPPHFALNPIAKTESRLKVLNKLIKRKDVTALINACDAGREGELIFRLIAQYTKAKQPVKRLWLQSMTPGAIRDGFTHLREDKDMLPLADAARCRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDFWEVRAEFVCAAGIYEGRWLDTAHKKDENDPEKRAERLWSKAAAESIVAACRGKMGAVREESKPTTSMAPALFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYLSTVKQALETVSENNNYQQFAAQILNKGWVKPNKRIFDNTKISDHFAIIPTTQAPKNLSEPEQKLYDLVTRRFMAVFFPAAEFQVTTRYTEVSGHQFKTEGKVMTNPGWLAIYGKEAADEKDPENSGTLVAVAKDEKVKTDKITANGLVTKPPARYTEATLLSAMEGAGKLLDDGELREAMAGKGLGTPATRAATIEGLLYEKYLLREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLSQIERGTISREEFMREIAQLTQIIVKRAKEYDNDTIPGDYATLLAPCPNCGSVVKENYRRFACTKCEFSMSKTPGSRQFEISEVEELLTKRTIGPLQGFRSKMGRPFAAILKISRDEEIKNYKLEFDFGQNDDEGEDGEGVDFTGQTALGPCPKCGNGVYEMGLAYVCEKAVAKPKACDFRSGRIILQQEILPEQMVKLLNDGKTDLLPGFISQRTRRPFKAFLVKGKDGKVSFEFEERKAKAPPKGKAKAAAVEGEEDEVTAVAKKPAAKKPTVKKAAVKKAAPKRVVAKRKAA
(538) DNA topoisomerase III [Delftia acidovorans SPH-1]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHDEYFESEHYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKPVDKTKSRLNAVVKLAKRKDVTELINACDAGREGELIFRLIEQYAAGAKPDGKGLGKPVKRLWLQSMTPQAIRDGFQNLRSDAQMLGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHAAFDAQAGQYLGKWFDTQWKKSEDAEARADRIWNQRDAQAIADAVRGKPAQVTEESKPTSQASPLLFDLTSLQREANGKFGFSAKTTLSLAQSLYERHKALTYPRTDSRALPEDYVPVAHQTFAMLAGSGMRHLAPFAQQALDENYVRPTKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEHQVTTRISKVEQHSFKTEGKILVKPGWLAIYGKEAANEVEGGKDGDKGQPLVAVQPGEQPRAGQVDPKGLKTKPPARYSEATLLGAMESAGKQVEDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSRADLTGEWEYKLAQMEKGQLSRDAFMQQIQAMTEKLVKKAKEYDRDTVPGDYATLSTPCPNCGGVVKENYRRYGCTGSDGQGAGCGFSFTKSPAGRTFETAEAEQLLRDRRLGPLDGFRSKAGWPFVAEVTIVHDEEGGNYKLEFDFGDDAASEDTGELVDFASQQSLGPCPKCGAPVFEHGSNYVCAKAVPTLAQATPSCDFKSGQIILQQPIEREQMQKLLQTGKTDLLDKFVSNRTRRSFKAFLVWDGAAGKVNFEFEQRDSKYPPRKTAAAKSAPAKKAPAKKAAAKTTAKTATKTATKTARKPAAGTLQPSAALAAVIGEGTVARTEVVKKLWEYVKAQNLQDPKDKRVIRADDKLRPVFGKDSVNMFELAGIVGKHLTP
(88) DNA topoisomerase [Delftia acidovorans SPH-1]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLSGSGVTITWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSAPFWAIDVSLSTEGQAFSAQWVAPDGCTDDAGRCLQQPVAQQAALQIRVADNTQVVSVETERVREGPPLLFDLSTLQEVCSKQLGLDVQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPAVLDSLLKTDPSLRPIMSQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSPLSEKELAVYRLIRAHYLAQFLPHHEFDRTVAEFSCGQQMLVATGKQVVVKGWRLVLAEPQADEDGDDAARSQVLPPLRGGLACQVAEVEIKALKTMPPKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQLIAQYGSMSLSIKLPHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTPKRGASRSRSSGRKGA
(252) DNA topoisomerase [Cupriavidus necator N-1]
5
MLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAKTESRLKVLNRLIKRKDVTALINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTQQAIRDGFASLREDEDMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKSEFDPEARESRLWSEAEAKSIVAACRDKTGTVTEESKPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLDTVKQTMDMLADSSPNYLPHAKKILAQGWVKPNKKIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKVESVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVLELTQAELTGEWEHKLSQIERGRMKRDEFMLEIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENYRRFACTACEFSISKIPGGRQFEIEEVEELLLKKEIGPLQGFRSKMGRPFAAILKLGKDDEGHYKMEFDFGQNDDDNDGEPVDFSGQEPVGTCPKCGGSVFEHGMKYVCENSTTSPKSCDFTTGKIILQQEISREQIGKLLTDGKTDLLTGFKSSRTGRNFKAFLVKQPDGKIGFEFEAREPKAGAKTAAKTTAKAASNGTAEAAPATKTAAKTAAKTPATKAPAKKPAAKKAPAKTAAAKKSRAAAAGE
(1786) DNA topoisomerase 1 [Campylobacter hominis ATCC BAA-381]
1
MKNLVVVESPAKAKTIGKFLGDNYNVIASKGHIRDLPKKTFGIKINEKHFEPVYEISEDHAKIVSEIKKLAKKADQIYLATDEDREGEAIAYHIATAIGKEPANLPRIVFHEITKTAIENAIKNPRALDTASVNAQQARRLLDRIVGYKLSPLLSQKIQKGLSAGRVQSSALKIVVDREREINAFKPEKFYTVNMIFKKDLEAEFVKFKNKKIEKMSIKTAKEADEIVQILCDEKFEVSKIESKDRKTNPYPPFMTSTLQQNASTALGFSPKKTMNLAQSLYEGVNAPNGGAITYMRTDSLNIAKEAIVSVRDMIKNEFGSEYLPKSANFYATKSKGAQEAHEAIRPTDLKFTPAIAAKSLPKDELRLYTLIYNRFVASQMNPCVSEIQNVFAKSGSSLFKILGRKVKFDGFYKIYGENDKDKILPDFKIGDELKVQNLKSVENQTEPPARYSEASLIKKLESLGIGRPSTYAPTLSLLISRKYVNTEKKQLVPTEIAFKIVEMLEQNFNNIVDSEFTSKMETKLDEIAEKSADWQEILADFYYPFMEKIAIGKKNIKSQKVAEPIGEKCPECGGELLKRNGRFGEFIACSNFPKCRYSRNLSGEQKIKKEPAKIGVKCPECGGEIVERVSKRGKFYGCSNYPKCNFISNYKPTNEKCPECGEMLFKKSLKKGDFLYCAKCKFQKAIDD
(1151) DNA topoisomerase 3 (DNA topoisomerase III) [Campylobacter hominis ATCC BAA-381]
3
MKLFIAEKPALAKSIAAGIDGEYKNGDGFFQKGENIITWAFGHLLELYMPEDYDENFKKWDLKDLPLKIDEFKYKPIQSSKEQLKIICNLIKRSDVDTIINCGDADEEGQILIDEILKYANNKKPVLRLLLHDLTEKGVRSELKNMKSNNDFSNLSECGFARSIADWIVGINLTRAYTTKAQNNGYKGVISVGRVQTPILGLVVSRDLEREGHKSSFYYTLTGKFKTHQAEILANLKTDEKITDENEANEIKNICLGKNGILNVTNENKLEYPPLPYNLLNLQADCSKKFNFKPDKTLKITQDLREKYKCITYNRSDCEYLPVNMWESSTNVLNSIKSNLSDFENIIKNADPNLKSRAFNDEFITAHFAIIPTETTFDFNSMSKDEQNVYKLISKRYIAQFYEPMQYLQTNIEILINDYKFTTSKKKITKNGYLSLFSGENDSEQKNDDEVENSFDLSLLESGNCQTLNIEINKKQTKPKPYYTMPTLLKDLTSISKYVKDEKIKTLLKEKDKDKKGENGGIGTPATRSEHIKNLFEREYIREEKKSIISTKKGRDLIALAPKILSTPDMTALWYEQQLEIQNGNLSKDDFLNRVFDEVEEQIELIKNNALLDKNFNGIDKTYPCKCGKGFLQKRHSQKTGKDFWGCSNWKNGCSEIYPDLNGKPNIPKYFCPKCGSALNRWKNKKGDGYYWSCSGWKTKGCQIGFINDKNGKPEI
(133) Reverse gyrase [Caminibacter mediatlanticus TB-2]
6
MLEAIYKNRCVRCLGDITSLRLSRGEFCDKCMQEIENLENCNELLNFKKFCEANKKLEEFNNFFKEKTGSTLNSIQKMWAKRYFLDNSFSLLAPTGIGKTTFGLLLSAFVNNSYIIFPTKLLVSQAIERFKLWGIEVLAYTGKKNEKEKIKNGEYNILITTTQFLYKNKKLINKNFDLVFVDDVDSILKSGKKIDDILGLLGFNEEDLQKAMELINKKEYEKISEIAKKKRGNLIVSSATANPKSKRILLFKYLLGFEVSRPNLTLRNIEDLFDEKFSWELSIEWIKKLGIGGLLFLPGNETKEKLYEYLEFLNNKGIKAYSYEEFNDHIDEFKKGECYFVGFASYRNPLARGIDLPQAIRYTLFVGVPKMEFNLNEDNFRSLYLILLSVFPYLMKNNLLDKKEAIEFQNYINFMKKYVFYTILHPKIEEKLRLISTKIKILIKKYENEIKNSPEISFDGEKIITADITGYIQASGRSSRFFNGHLTKGLSLVLVDNKKAFFSLQKKLKWFSEAQFKRVDEVNLEEILEEVEESRKIKKEIKLKTSFVVVESPTKAKTISSFFGKPSKRIINGVSVYEILLEDRNLVIAASVGHDFDLVEDEGDFGVIKKYIPIFKVLGEKDNILKALNLTSSEVEEVYIATDPDREGEKIAFDLTLNNKPFNLNIKRAEFHEITKYAFEDAIKNPREVDLNLVASQFVRRIADRWIGFKVSLYLQKLLKNAHLSAGRVQTPVLKWICERTSKLKEKIYIVRIIFDEIKVDFEFEDKKEAENFYNSLGEYIEIKKISSKEESLLEKPFNTSELLKEASIKLRFSPQKTMQLAQELFENGLITYHRTDSHRISSLGMSIAKEYIKENFGEEFIKLRSFEEGGAHEAIRPTSSMDSEDLRSFIAFKNLELNNEHIKLYDLIFRKFIASQMKEAKVLKETYDILGKNEEFITKIIEDGFNLIYPIKVYNVNEGKKKIEKLKLQKSKYPPYTYADIIELMKQKGIGRPSTYAITIEKLLDRKYVVEKNGYLFATKLGFKVIDIVFNSEYKEFLDEEYTAFLEEIMDKVEKGEVNYKIILEELYQKVILNQK
(1564) DNA topoisomerase 1 [Caminibacter mediatlanticus TB-2]
1
MAKKLIIVESPSKARTIKNFLGKEYEVIASKGHIRDLPKTSFGIKIEEDKFIPQYRVTKDHQSVAKELKEKAKKAETIYIATDEDREGEAIGFHIAHVIGKDPSSLPRIVFHEITKTAIKNALKNPRKLDIDRVNAQQARRLLDRIVGYKLSPLLNKKIQKGLSAGRVQSAALKLVVDREREIKEFIPKEYWSIEGIFKEVEGNLIKYNGKKLEKFDLKTRDEAEKIVNELKPLEYEVSKIEKKTTTTKSPAPFMTSTLQQVASSELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQEAAINFIKENIGSEYAEAKTYTTKNQTAQEAHEAIRPVDVRLTPDDLKNYLSKDELKLYSLIYNRFLASQMKDAKFETQNIYLTNEKGEFKISGKKLIFDGFYKVYGKRGADTLLPEFKEGEKLKPEEIKATQHFTKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEIKDKKLHPTEIAFNVIETLEKHFPDIVDAKFTANMEEMLDEIARGNKDWQEMLKEFYNPFMKLIEKGYEEIPSQKIAKPTGELCPECGNPLVIRKGRFGEFIACSNFPKCKYTRPIEEKEEKKVDVKCDKCGADMVIKRGKRGEFLACSNYPECKNTKPLNPPEVLEDVKCPECGGDIIKRKSRRGEFYGCGNYPKCNFISKYRPVNEKCDECGYMMAKRTYRNKEVLECIKCKARKEI
(1046) DNA topoisomerase 1 [Arcobacter nitrofigilis DSM 7299]
1
MKNLVIVESPAKAKTISKFLGSEYKVMASMGHVRDLPKSKLGFDPADNFKPQYLISTDKRKVIADLKKEITKDTTIYLAADEDREGEAIAWHLIPALKVEKNPLKRIVFHEITKGAILKALENPREVNQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFIPEEFWKIKADFINPQLNTELAKIDGKVKKIKNEQEAKVIEASINQGEFELFDIDESESKRNPAAPFTTSTLQQEASRKLGYSVKQTMVIAQQLYEGNIQNIPNHTGGLITYMRTDSLNLSTVATSAAKEVIEKTYGAEYSLKSPRVYKSKAKGAQEAHEAIRPVDLSLKPSMIKAYVDNAQFRLYSLIWKRTLATQMQTAKIANTTYKISAGKDKEYEFQVKGQRIIFPGFMKVYTEGSDNPESALDSSEKILPSIKVGTKLDLEKLDLEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYITKSEDKKLIPTPTGEIVNSFLTDHFPNILDLGFTAKVEEEFDDIADGKIAWQQVMKDFYGDFKKTIDEKEESVNKEDYLQIREIGTDPKSGKPVSARVGRFGPFVQIGTKDDEEKPLFVAIPAHLNMDTITMDEAMFLFTLPRVVGQTADGEDIKANIGRFGPYLQVKTKYYSLKEDDPYKIELPRALELIKQIDEEKAKATIKNFEKEKIQVLDGRYGPYIKQGRKNYKIPKGKDAASLELEDCLSIIENDSKTSKRAPAKKTAAAKTTTKTATKKAPAKKAPVKKTTTKKTTAKKEK
(974) DNA topoisomerase 1 [Helicobacter mustelae 12198]
1
MKKLIIVESPAKAKTIQNFLGEEYQVIASKGHIRDLPKMRFGIHIKQESFEARYVIDEDHQEIAKNIKELAKQSSQVYIATDEDREGEAIGYHITQAIAKDPQSFPRIVFHEITKTAIQDALANPRNIDMNKVNAQQARRFLDRIVGFKLSSLVSSKIAKGLSAGRVQSAALKIIIDKEREIQKFIPLDYYSIEGNFLGLSAQLIAYQGKKLKEQEITEEARAKQMQENLQKNLYTIGDLQKKSKKSPTPPPFMTSTLQQSASNLLGYSPTRTMSIAQKLYEGVQTHQGYMGVITYMRTDSLNIAKIAQDQAREHILKAFGQAYLPKKPKIYATKNKSAQEAHEAIRPTNLDFTPEIAKNYLKNEELKLYTLIYHRFLASQMEDAILESQSITFIGEEGEFKANGRRLLFDGFYKVLGNEDKDKLLPELEVGAKIKPQSLEVNKHTTQPPARYSEASLIKILESLGIGRPSTYAPTIALLNSRYYIKIENKQIHPQESAFKVIEMLENHFDKIVDATFSASLETKLDEIAENKQNWQKFLWDFYEPFMEQINAGKTDIASQKMKIPTGEYCPQCGSELLLRESRYGEFTACGAYPKCKYIKPQEEEGEKDPESCEKCGKPMVTKMGRNGSFLACSAYPECKNTKSLLAKPSQQKVLEGVACPECGGEILLRNSRRGAFYGCSNYPKCNFLSKFPPTNHKCPECNYLMNDRTYRGRAIFECIKCKHRVDQ
(1542) DNA topoisomerase 1 [Bartonella grahamii as4aup]
1
MNIVIVESPAKAKTINKYLGSQYKVVASFGHVRDLPAKDGSVLPDRDFSMKWDIDSSAAKRLNEIAKAVKEADSLILATDPDREGEAISWHILDVLRQKKVLKDKPIKRVVFNAITKKSVLDAMNNPRDIDTSLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRIICDRESEIEHFIKEDYWSVTTQLKTIRNDSFQARLTMFNQRKIGKLDIQSQEQADQIRFMLEKSQYHTLSVEAKPTKRNPLPPFTTSTLQQAASSKLGFSASRTMQIAQKLYEGIEINGETAGLITYMRTDGVQIAPEAIDSARKVIHETFGKDYIPEKPRFYSTKAKNAQEAHEAIRPTDFQRNPSQVRNFLDSDQAKLYELIWKRAIASQMRSAEIERTTVEIEAQQGENRANLRATGSVIRFDGFISVYTDQRDEENNEENETTRLPQVNTGEALTKEKVESVQHTTEPPSRYSEASLIKKLEELGIGRPSTYASTLATLCDRGYIVIDKRKLIPDAKGRIVTAFLENFFNRYVEYGFTADLEEKLDLISDGKLSWKDVLRDFWDGFNASISNIQELRITNVLDVLNVTLAPLAFPEREDGSDVRSCPLCKNGQLSLKLGRYGAFVGCSNYPECKYTHQLGTDTGEENEAVRNDEPVILGIDPETGKDISLRNGRFGPYIQLGESKEVKRAGLPKEWQAENVTLDKALALLSLPREIGVHPESGKTITATIGRYGPYLSHNGKSARLLHADEVFDIGINRAVTVLAEQQENKTKQSRATPAALAILGEHPEGGTITVRNGRYGPYVNWGKINATLPKDKDPISVTLPEALELISAKASSKKTTSKRASSKTKAKIKET
(872) DNA topoisomerase 1 [Methylomonas methanica MC09]
1
MSKSLVIVESPAKCKTIEKYLGKDFQVLASYGHVRDLIPKEGAVDPEHGFAMKYQVIDRNQRHLQEIGKALKNADTLYLATDPDREGEAISWHVFEHLKEKKLLKDKQVLRVVFHEITKKAVTEAIEHPTELSLTMVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRMIVERELEIEAFKTREYWSHTADASAQGQPFKAKLTHFNGEKLTQFSITDETQANQVKQALLDAGDGQLIVAKLEKKQRSKNPAPPFITSTLQQEAARKLGFTTKRTMMVAQQLYEGIDLGGETVGLISYMRTDSVNLADEALADIRALIAEKYGAGNVPKEPRQFKTKSKNAQEAHEAIRPTSVQRLPEQVKERLTVEQFKLYDLIWKRTVACQMIHATLNLVAVDLNCGSDKNVFRATGSTVTNPGFMMVYLEGVDDSKEATDDQDRLLPPMEEGRPVVLNDVTANQHFTEPPPRYSEASLVKALEEHGIGRPSTYATIISTLQNREYVTIDSKRFYPTDVGRIVNKFLTEHFTKYVDYDFTANLEDDLDAVARGEKDWIPLMNDFWRPFTQLISEKEESVQRKDVTQESIDEQCPECGSPLSIRLGRNGRFVGCTNYPTCSYTRNLGEDSAAATAEPEVVEGRVCPKCASPLVIKTGRYGKFVGCSAYPTCKHIEPLEKPQDTGVECPQCKKGSILKRKARSGKIFYSCSEYPKCSYALWDAPIKESCPDCHWPILTLKTTKRRGTEKVCPQKECKYATPYEGDPEDVNGPG
(504) DNA topoisomerase 1 [Xanthomonas albilineans GPE PC73]
1
MSKHLLIVESPAKAKTINKYLGKDFHVLASYGHVRDLIPKEGAVDPDDGFAMRYALIDKNEKHVDAIAKAAKAADDIYLATDPDREGEAISWHIAEILQERGLLKGKPLHRVVFTEITPRAIKEAMAHPRQIAGDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFLAREYWTIGAECAHPSQPFAAKLVKLDGQKFEQFTITDGATAEDARMRLQKAAQGALHVTDVTSKERKRRPAPPFTTSTLQQEASRKLGFTTSRTMRVAQKLYEGVTVGDEGTVGLISYMRTDSVNLSQDALVEIRDVIARDFGTGALPDKPNTYQTKSKNAQEAHEAIRPTSALRTPAQMAKYLDDDGRRLYELIWKRAVACQMVPATMNTVTVELAAGSEHSFRASGTTVIDPGFLAVYEEGKDQKAAEDEDEGRKLPAMKPGDRIPLDRIHADQHFTEPPPRYSEASLVKTLEEYGIGRPSTYASIIQTLMFRKYVELDARRFRPTDVGRAVSKFLSGHFTRYVDYDFTAKLEDDLDAVSRGEEEWRPLMEKFWGPFKELVEEKKESVDRSEATGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEDKPKFASLRPGQSMHTITLEEALELFLMPRLLGQDKGDDVSVGIGRFGPFAKRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKQFPDSDIQVLNGRFGPYISDGKLNGKIPKDREPSTLTLDEVQKLLEETGKPVRRGFGAKKVAAKKEAAPKKSPAKKTVADTPTKTAAKKAVKKATKKTVKKAVKKAAKKTVAKVAKGA
(120) DNA topoisomerase 3 [Proteus mirabilis HI4320]
10
MRLFIAEKPSLARAIADVLPKPHKRGDGFIVCGDNQYVTWCVGHLLEQAEPDAYDPRYARWSLDDLPIIPNKWQLKPRADVKKQLDTINTLLKQADEVIHAGDPDREGQLLVDEVLNYLNISDAQRKQARRCLINDLNPAAVSRAIDKLRYNHEFIPLCVSALARARADWLYGINMTRAYTLLGQRNGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDFFEVKAHIVTPADERFTAIWQPSEHCEPWQDEEGRLLHRKLAEHVVDRIAGKPANVTDYQDKQESEIAPLPFSLSALQIEAAKRFGLSAQQVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVMNAISVHDNSLLPQETLDIDKKNRCWDDKKVDAHHAIIPTAKTGNISLSENEKNIYYLIARQYLMQFMPDAVYRKCVIELDIENGKFIAKARFLAQAGWRTLLGSKEQDAENDGSALPIVAKGDELLCEKGEIVAKQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRGFLQKKGRAINSTPAGRALIHVLPDMATLPDMTAHWESILTQISEKQFKYQDFMMPLSNTLFELITQAKRRPNIQAFRNLPAPAQNKKRKGATKKSAQGKSRSAQSQSTNRNIKSDA
(1301) DNA topoisomerase [Proteus mirabilis HI4320]
4
MKLFLCEKPSQAKDIARVIGAHQRRDNFFQGNGVQVAWARGHLLEQAEPEAYGAQFAAPWRQSALPVIPEQWKMVVKKDAVSLFQTIKQLLSQATEVVIATDADREGEVIARELLEACHYRKKVQRLWLSALDEASIRQALNNLLPGEKTASLYSAGLGRARADWLIGMNMTRLFTLKARELGFGGILSVGRVQTPTLALIVRREREITHFVSKPFWRVTASLQHQGIIFQAHWRPASQYCDDEHRCIHVQAAQAVEQLCRQAGKATVCTVNETKGKALPPLPFDLGTLQQAASRRWGYSADKVLEIAQSLYEKHKATTYPRTDCGYLPVSMRADIPVVLDALSQSDPALQNVLAQLQPARISRVWNDAKITAHHAIIPTRQTPDLNAMNEAELNVYKLIRAHYLAQFLPDQEWDATEVFLDIGGQQFVAKGKVERVKGWSVLFVKHEDDPPVKEEAETGLEAGTETLPSLHEGEFCVVQEAKVVQLATSPPKPYTDGTLIAAMKNASSFITDPTLKKVLKENAGLGTEATRAGIITTLENRKLIVRQKKTLRATDTGCQLIDALPAACTDPGMTALWEQSLEQVAQGNLSLDVFMQKQISWLAHLIKKGGEMPLALDLPPMPSCPSCHGKMVLRESSKGRFWSCQRYPDCKGSVPLPEKMQGVTRGMNKRKKAVKKSITGLFT
(1656) DNA topoisomerase 1 [Proteus mirabilis HI4320]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPKSGSGSQKSENSSATKGVKKVKKDEKSALVSRMGVDPYNGWHANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGEDDRFSRVVFNEITKNAITQAFQTPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLLVEREREIKAFVPEEYWQLHASLLTPDEQPLRMEVTHYQDNAFKPVSSEETQVAVKALQNATFIVKNREDRPTSSKPSAPLITSTLQQAASTRLSFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDAIQMARDYIHDKFGAKYLPKEPNVYSSKENSQEAHEAIRPSDINVTAESLKDMDSDAKRLYQLIWDQFVACQMTPAKYDSTTLTVVSGDYKLRAKGRTLRFAGWTKVMPAMRSKDEDKTLPAVDVGAQLALAELSPTQHFTKPPARFSEATLVKELEKRGIGRPSTYASIISTIQDRGYVKVENRRFYAEKMGEIVTDRLEENFSDLMNYDFTAQMEDHLDHVANNQENWKAVLDAFFTDFSQQLEVAEKDPEEGGMRPNPMVITSIECPTCSRHMGIRTATTGVFLGCSGYALPPKERCKQTINLIPEDELLNILEGDDAETNALRARRRCPKCGTAMDSYLIDTHRKLHVCGNNPACDGYEVEEGEFRLKGYEGPVIECDKCGAEMHLKMGRFGKYMGCTNEECKNTRKILKSGEIAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPKVAELVRFKDRLSEKMRYLAQAPVTDPEGNPTIVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEKSK
(514) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Heidelberg str. SL476]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(1555) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Heidelberg str. SL476]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(725) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Agona str. SL483]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVDTLYQLIEQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(1136) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Agona str. SL483]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1114) DNA topoisomerase III [Delftia sp. Cs1-4]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHDEYFESEHYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKPVDKTKSRLNAVVKLAKRKDVTELINACDAGREGELIFRLIEQYAAGAKPDGKGLGKPVKRLWLQSMTPQAIRDGFQNLRSDAQMLGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHAAFDAQAGQYLGKWFDPQWKKSEDAEARADRIWNQRDAQAIADAVRGKPAQVTEESKPTSQASPLLFDLTSLQREANGKFGFSAKTTLSLAQSLYERHKALTYPRTDSRALPEDYVPVAHQTFAMLAGSGMRHLAPFAQQALDENYVRPTKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEHQVTTRISKVEQHSFKTEGKILVKPGWLAIYGKEAANEVEGGKDGDKGQPLVAVQPGEQPRAGQVDPKGLKTKPPARYSEATLLGAMESAGKQVEDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSRADLTGEWEYKLAQMEKGQLSRDAFMQQIQSMTEKLVKKAKEYDRDTVPGDYATLSTPCPNCGGVVKENYRRYGCTGSDGQGAGCGFSFTKSPAGRTFETAEAEQLLRDRRLGPLDGFRSKAGWPFVAEVTIVHDEEGGNYKLEFDFGDDAASEDTGELVDFASQQSLGPCPKCGAPVFEHGSNYVCAKAVPTLAQATPSCDFKSGQIILQQPIEREQMQKLLQTGKTDLLDKFVSNRTRRSFKAFLVWDGAAGKVNFEFEQRDSKYPPRKTAAAKSAPAKKAPAKKAAAKTTAKTATKTVRKPAAGTLQPSAALAAVIGEGTVARTEVVKKLWEYVKAQNLQDPKDKRVIRADDKLRPVFGKDSVNMFELAGIVGKHLA
(1869) DNA topoisomerase 1 [Shigella sonnei Ss046]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTIGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKIGEIVTDRLEENFRELMNYDFTAQMENSLDLVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(131) DNA topoisomerase 3 [Shigella sonnei Ss046]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIIPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERALDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLLQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDVVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA
(1846) DNA topoisomerase 1 [Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica)]
1
MEKNLVIVESPAKAKTIEKFLGKGFSVKSSIGHIRDMPKKNMGIDIENNFAPTYEITTDKKKVVADLRKAVKAAEKVYLATDEDREGEAIAWHLLEALNLPKDTPRIVFHEITESAITHAIVEPRTVDYQLVDAQQARRIIDRLVGFEISPVLWRKISGARSAGRVQSPVMRLVVEREREISQHITNSTYKVKAELTSEGGGLFEVKLSKEFESKKKVLDFINAFLSANLTVTSIEKKSYKRSPKPPFITSTLQQEASQKLGFSVKQTMTLAQNLYREGFITYMRTDSFTLSEIAIDVTGQIIVKEFGSEYHHIRRYKTKDTSAQKAHEAIRPTNLTKPSIFGIEDQAAKLYSLIYKRTLACQMSDAQLQKTQIKINISGLDEKFLANDEILTFPGFLRVYDYFSSENKLLPDLNKEDMLSLASFKARESFSRAKPRYTEASLVKKIEEMGIGRPSTFATMVSTVQDRNYVTKETREGVERGYQLIEIKDNQIIQSQPSEVTGAEKNKLFPTNVAYLLTDFLVKYFNNIIDYEFTAKLENDFDAIATQNISWQGVVKNFYTPFHKKIEDAADISREETHGMRELGTDPKSGKLVSVRFGRYGAFAQIGHKDDEDKPIFASLRDSLDIESITLDEALELFNMPRTVGETDDFGTIKANYGRFGPYIEYDKKYVSLKEDIPEKVSLEKALELIAYKEKFDAERIIKTFDDSNIKVLKGRFGPYIWNGKKKGKGQKNITIKKVFGNKNPVDLTLKECKKAVSGKIKAKAKPRKKKKVIKK
(1066) DNA topoisomerase 1 [Nitrosococcus oceani ATCC 19707]
1
MSKNVVVVESPAKAKTIKKYLGKNFEVLASYGHVRDLMPKEGAVDPEHGFKMKYQAIEKNGRHVNAIAKALKSADFLLLATDPDREGEAISWHLLELLKEEGVLEDKAIQRVVFYEITSQAVNEAVAHPRDISLDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIDAFKVREYWTLEADAAASKQEFVAKLTHLDGKKLAQFDIESKDQALALVDRLTKAASGELRVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSTKRTMSVAQQLYEGVDIGDGAIGLITYMRTDSVNLANEAVGEIRNFITERFGQSGLPAKPRTFKTRAKNAQEAHEAVRPTSVYRVPEALKPHLKPEQFKLYQLIWRRTIACQMKHATIDTVAVDLNTQKLAPEGGNSASGHIFRATGSTVVDPGFMAVYQEGRDDIKGEEEQRKLPPMKEGDRVTLLQIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRDYAVLENKRFQPTDVGRVVNRFLTEHFNSYVDYDFTARLEDELDAVSRGEKVWIPVLEEFWGPFSARIQEKEQNVSREEAVQARELGIDPQSSRPVSVRMGRYGPYIQIGSKEDEEKPRFAGLQPGQKMDAITLEEALTLFKLPRELGFTPGGEQVSVNVGRFGPYVKYDNKYVSLRGEDPHTISLERALALIEEKKQADANRVIKVFPDSGIQVLNGRYGPYVTDGERNARVPKEQAPEALSLEQAQALINEAPVKRARRKAGTRKKAKG
(304) DNA topoisomerase 3 [Vibrio sp. EJY3]
10
MSRLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERYKKWNMADLPIVPEQWQLRPRKTSSKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCKLSKTKKQATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFIPKDYFTLHALIPYQDQNGAFDIRARWKPSEACKPWQDEEGRVLNRKLVENVAARIKNQPATVKESEQKQTKQSAPLPYSLSALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPMEHYAQVGSVTSAIANNAKELQSAVQGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQFYPAAIYAEAKLVFDIAGGTFIAKGRQLVSPGWKALMGKTDKEDDGIDAVPPLAEGTVLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGILDTLFKRQLLTRQGKSILSSPAGRGLVHALPQDATYPDMTAHWEFQLQGMAEKNQAYQPFMQALEQRIDSLMGEVKSGPIPESLRHLPKVERPAFKRKKRSYSKGSASKSGAPKRKSS
(989) DNA topoisomerase 1 [Vibrio sp. EJY3]
9
MGKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTAGQSTGEKAAAISTKGMSAEEKARVKKEKDRKALIKKMGINPYHDWEANYQILPGKEKVVSELQKLAKDADYVYLATDLDREGEAIAWHLREIIGGDEERYKRVVFNEITKNAIQQAFQTPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFVPEEFWDIHANTKTKDKADFKLLVAQKDGVAFKPVNEAETKAAMSVLEKASYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVDAVRDFIGSEFGDKYLPASPLKYGSKEGAQEAHEAIRPSSVDVKAEDLQGVDADAHKLYALIWNQFVACQMTPAEYDSTTISVKAEEFTLKAKGRILKFDGWTRVQRPMGKNEDTILPAVQLGDKLNLESLDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEQKLDQIAEGEVNWKSVLDNFFTDFTGDLEKADLDESEGGMKLNHIVMTDIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEEGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYIVEYGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHFPELPCENSDAYFVLRDGASGLFMAASNFPKSRETRAPLVSELALYEERLPEKFKYLATAPQEDPDGRPAVVRFSRKTKENYVRSEENGKPSGWTALYVDGKWEVTDKRKKAKA
(173) DNA topoisomerase 3 [Shewanella putrefaciens CN-32]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFIEAANGDCVSWCVGHLLEQAEPDAYNPEFKAWKFEHLPIVPDKWQLTPKAATRSQLTVLKRLVKQASMLVNAGDPDREGQLLVDEVIAYLGVTGDKLHQTQRLLISDLNPQAVKRALTQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDKEIANFQSKPFYEVLAHLATDKQETFSAKWQPSEACQPYMDEEGRVLARGLAQNVVSRISDKPALVTQLVAKDKKQHPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPVEQHNLAPSVLKAISDGAAELLQGADAPDPRLKSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHIARQYLAQFYPAYCYCETTVQVTIEGGLFNTKARQDKSLGWKQLFARQEPNGSKASGNKSTEESMGKDDEENDEFIGQLPPLKLGQALHCTRGELLEKNTQPPKAFTDATLLSAMTGISRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVSTDVGKGLINSLPLSATTPDMTALWEASLNGICHKETSYQGFMQPLLGTLSTLIQHAGAQLPTALNGLKGQGYRKTASHKSGYRKSYSKKSSSAKGIGTTKNDVSNKYGSKNTSSKSSVTRSTSRSASNSRKSTAAV
(620) DNA topoisomerase 1 [Shewanella putrefaciens CN-32]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSEGNEKVKSAAEVKKMSPEEKAQYKKVKDQQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAQLTTPAEESLRMEVVKHLDSAFEPINEQQALAAVQALSSASFNVISREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALESVRDMIGKAFGAKYLPAEPIRYGSKEGAQEAHEAIRPSNVHVEATDLTDMERDAQRLYELIWRQFVSCQMTPAQYDATKLTVKAGDYELKATGRTLRFDGWTRVQTVLKKKNEEDNTLPFVSQGDVLALKELQPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSERLVSSFADLMSYDFTASMEQTLDDVARGELDWKKVLDGFYADFTKQLEKAERDPEEGGMRLNQMVMTDIKCPTCGRPMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGVEAISENSEDAETDALRAKHRCGICGTAMDSYLIDEKRKLHVCGNNPICEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNEECKNTRKLLKNGEAAPPKEDPIYLPELKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPICDDEGNKAAVKFSRKTKEQYVATEVDGKATGWSAHYINGKWVSESTAKKSKKA
(1554) DNA topoisomerase [Nitrosospira multiformis ATCC 25196]
5
MGKTLIIAEKPSVAADIARALGGFTKHTDYFENDEYVVSSAVGHLLELAVPPEHEVKRGKWSFTNLPVIPPHFDLNPIEKTESRLKLLTRLIKRKDVDALINACDAGREGELIFRYITRHVGTKKPVKRLWLQSMTPASIREGFNKLLDDEDVWPLAEAAVSRSEADWLVGINGTRAMTAFNSQEGGFHKTTVGRVQTPTLAILIEREDIIKKFVPRSYWEVHATFSAREGSYKGRWFDESFTKARKDNEQKAERLWDHATAEAIRVKCLGKSGVVTEESKPATETCPLLYDLTSLQRDANGRFGFSAKTTLSLAQALYEKHKVLTYPRTDSRALPEDYIATVKETLGSLQNSGYGAFAAQILGAGWVKPNKRIFNNAKISDHFAIIPTTIEARGLNEVESKLYDLVVKRFLAIFYPAAEFLVTTRITRVENEPFKTEGKVLINPGWQAVYGKEAQPSGTEDNSTLVKLEPDEPVTAEEIEVASHQTRPPPRFNEATLLSAMEGAGKWVEDEELREAMSAKGLGTPATRAAIIEGLVSENYIQRVGRELHPTAKAFSLITLLRGLKVPELTSPELTGDWEYKLRQIEQGKLERNKFMAEIAEMTSHIVQQAKSHRGETISGDFSTLKSPCPKCGGVIQETYKKFQCQKCDFALWKILAGRQFETAEMEQLITRREVGPLQGFRSKMGRLFNANIKLTDELEMKFDFGADGEQDTEEVDFSGQEPLGKCPRCSGRVFDHGMSYLCEKSLGSAHTCSFKIGKIILSRPLEREQVMKLLQTGKTDLLTKFISKKGRPFSAYLVAGKDGKIGFEFEVKEAKVKTPAETEETKVAKPRAAPMKKTLSAKTR
(1196) DNA topoisomerase [Cupriavidus metallidurans CH34]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQLKRWSVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDACTDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAKFSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVADVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGSSKRGASRPRRSGRKGS
(1305) DNA topoisomerase [Cupriavidus metallidurans CH34]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDDYEVKRGKWSFANLPVIPPHFDLRPIAKTESRLKVLNRLIKRKDVTALINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFAALREDEEMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKNEFDPEARDSRLWSEAEAKSIVAACRDKQGTVTEESKPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLDTVKQTMDMLADSSPNYLPHAKKILSSGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPTAEFQVTTRITEVAGHHFKTEGKILVNPGWLVIYGREAQGKDDKDANLVPVQKDEKVKTDKVESVGLTTRPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLAEKYLVREGRELIPTAKAFQLMTLLRGLGVEELTQAELTGEWEHKLSQIERGRLKRDEFMREIAQMTQQIVKRAKEYDNDTIPGDYATLDTPCPQCGGQVKENYRRFACTACEFSISKIPGGRQFEIEEVEELLLKKEIGPLQGFRSKMGRPFAAILKLAKDDDGNWKMEFDFGQNDDEGDGEPVDFSEQTPVGKCPKCGGSVYEHGMKYVCENAVGSAKSCDFTSGKIILQQEISREQIGKLLTDGKTDLLTGFKSSRTGRNFKAFLVKQPDGKIGFEFEAREPKAGAAAKTAKPAAKSAAKAESAPAKVAAKKAPAAKKAATKTATKTAATKTAAAKKTRATTKQTAEAEE
(1557) DNA topoisomerase 1 [Myxococcus fulvus HW-1]
1
MATRTKKKVEETEAAEEKAPAKKAAAKKKPAARKKTVAKKKTAARRRTKKGDEDALPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREGEAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQISPLLWKKVRRGLSAGRVQSVAVRLIVEREEEIKAFVPEEYWTLDALLEGPSGPPPFKAKLSKVDGKKVELKDRATTEGLVAELQSASFSVAKVDRRERRRNAPAPFITSKLQQEAANRLSFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFLPDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKGFFEAMGEEDMYRLYELIWNRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEGADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVMVEEETTDELCEKCGKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRDGPYVACPNKECDYRREITEQPAGPGGSPEASSAA
(1338) DNA topoisomerase 1 [Geobacter sp. M18]
1
MSQNLVIVESPAKAKTIEKFLGPEYKVLASFGHVRALPSKQGSVDVEHEFEPKYAVLPESKKHIDAIKKEMKGITSLLLATDPDREGEAISWHLLAALGLDGKKKASFDIKRVVFHEITKDAIVHAVQHPRGISVDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIGAKLETAKKQALTAALVEAEGKKLSKFDIPNQEAAFRLFGLLGGKEFPKQEGEEGSAPLVVKAPVNPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEDARQLITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYISKTPIEVKKFLTSDQFKLYDLIWKRTVACQMAEALLDQTSVEITAGEGFRFRVAGTVIRFAGFMKLYIEGVDDEAEDKEKEGMLPPLKEGDILKLQQLLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFNQYVDYNFTANLEEQLDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVSKSDLTTEATDEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEELCDKCGSHMLVKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCTACGKGELIEKKSRFGKLFYSCNRYPECKFALWDQPVQKPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYQSNKE
(95) DNA topoisomerase 1 [Desulfobacca acetoxidans DSM 11109]
1
MTKSLLIVESPAKARTLQKYLGKDFEVRASVGHIKDLPKKELGVDVEKNFIPKYVTIDGKTKTIQDLKRAAHDVEDIYLGPDPDREGEAIAWHIAEVLKSGKHRFHRVLFYELTPRAIQEALAKPMELNRPRYEAQQARRILDRLVGYQISPLLWEKVKRGLSAGRVQSVALRLICDREREILAFVSQEYWSLTAHLKAEQPPPFQAKLIRYKGKKLELAKAEQTQAVVAALEGAQYTVTAVEQKERQKKPLPPFITSTMQQEASRKLRFAAKKTMQVAQRLYEGKDLGAAGPVGLITYMRTDSTRVAGEAVAAVRDFIRQEFGPDYLPAKPNAYKSRKTAQEAHEAIRPTDVSRTPAAVAPFLEKDELRLYELIWKRFVASQMEPARLLVTTADISANHYTFRATGTVVKFPGFTVLYEETPDAAGEEEDIKLPPLKVGELLELLQLEPKQHFTQPPPRYTEATLIKELEKQGIGRPSTYATILSVILGRLYVAKIKAGFKPTELGLMINDLLVASFPKIMNVGFTANLEDRLDAVAEGEVIWQEVLRDFYGSFSQELQEAKQVMPRVKSLATGLTCPQCGAELLIKWGKTGEFLGCSGYPECRYTRNFSRDEQGRIVPEEKNNVPAPDLPEITEVCPKCGQTLVAKQGRFGPFLACPGYPKCRYTRSLQEEEGEVEAVPCPQPDCTGVLRARKSKRGVFYGCSNYPECTYALNYPPVAKACPQCGFPVMVRKELKKQGKILACPQKSCGYTEPDLDEPGTD
(1097) DNA topoisomerase 1 [Rickettsia felis URRWXCal2]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGEAISWHVAEVIKEKNKVKSDDFFKRVAFNEITKKAIIHAVENPRKLDANLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKDAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKNYGDKYLPNSPRIYKSKVKNAQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVASLASENKEYLAKANGSTIAFDGFYKVYRESVDDEAEEENKMLPPLKEQEPLKTKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVSLEKKRFMPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFSENKESKACPSCKTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENDGDLAATPNENKVLGTDKDGIEIYLKKGPYGPYVQLGEQEGKVKPKRSPVPASLNQNDITLEMALKLLSLPLKIGIHKDSGEEIMIGYGKFGPYIKYMGKFISIPKKYDFLNLSLDDAMKLIEDNKAKLEKKQA
(1755) DNA topoisomerase 1 [Rickettsia endosymbiont of Ixodes scapularis]
1
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGKYVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNKVKSDDFFKRVAFNEITKKAIIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKDAKDLTEKLKSQNFYVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAIADIRKLIDKSYGDKYLPTSPRIYKSKVKNVQEAHEAIRPTNITYTPDSLKEKLEKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAFDGFYKVCRESVDDEAEEENKMLPPLKEQEPLKTKEVIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYASILSVLQDRKYVSLEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKAALSNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKVCPSCKTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPSAIPNENKVLGTNKDGVEIYLKKGPYGPYIQLGEQEGKVKPKRSPVPANLNQNDITLDIALKLLSLPLKIGVPKDSGEEIMIGYGKFGPYIKYMGKFISVPKKYDFLNLRLDDAMKLIEDNKRS
(719) DNA topoisomerase 1 [Neorickettsia risticii str. Illinois]
1
MNVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKGSVDVTDSFEMLYKLTDTGETVVPQLIKDVKNATALYLATDPDREGEAISWHLVEVFKENDVLPKNVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSISPVLWKKLPGSKSAGRVQSVALRILCDRENEIGLFTPEEYWIVSVNMTDGEGLVIPTQLSHINGEKLERMSIRGAEEAEKIVEEIRELPFLVEEIKKKELKQKPSPPFITSTMQQTASTVLGFSVKKTMSLAQKLYEGIEIGGAIEGLITYMRTDATHLSVESVDAIREFIQKKFGQEYLPESPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAITSSQNIVFISQDEKFKTSASASLLIFDGFNAAFSHGKNKNKNQGVIDFIKKHKEGAQVKVGDVLPTQNFTEPPHRYSEAGLVKHLEELGIGRPSTYATVVSVLQERGYASIVNKSFIPENRGRLVSEFLVHFFSKYVEYHFTAEMEDRLDKVADGTIFWLDVIQDFWDSFHSNVEEVEKVPITEVLAFVNGALAKQKLVSAEVKVGDKCPKCEKGYMHLSVSRYGVFLGCTNYPVCRFIVNSYSTDDDTEYPKQIAQDISLHKGPYGIYLKYKGKNSSIPKDVDPVSIDEEFAHKIASLPKILGKHPADGKEIKMGLGPYGLYLFWNAKYYNLQFSQMDEMTLDKAVQFIQSYVIHDKSLLRVLGSYEGEEIQIRDGRYGPYIKCSKMNVPIPKAESPESLSIETAILLIEKKKNTSKSAKKVATKRKVSTKEKK
(1242) DNA topoisomerase 1 [Magnetospirillum magneticum AMB-1]
1
MRMKVVVVESPAKAKTINKYLGSDFHVLASYGHIRDLPPKDGSVRPDEGFAMDWETDPKSERQIKEIVAAVKGADKLFLATDPDREGEAISWHVRQVLEARKALKGVEVKRVVFNEITKSAVLDAMRNPREIHQELVDAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICERESEIESFKPREYWTIAADFLTPKGALLSAGLTHLGGKKLDKFDLSSEALARDAESKAASARYAVAAVERKRTRRNPYPPFTTSTLQQEASRKLYFAAARTMQLAQRLYEGVDIGGETVGLITYMRTDGVQMAAEAIAGARAVIAQDFGKVYVPEAPRVYKTKAKNAQEAHEAIRPTDLARRPEDVARYLDKDQLRLYELIWKRTLASQMAAAELDQVGVDIAGDQHGIVFRATGSVVVFDGFLKVYREDKDDSDDEDAEKLLPDVTEKDAMDRKAMRTEQHFTQPPPRFSEASLVKRMEELGIGRPSTYASILSVLQERNYVRLDQRRFIPEDRGRLVTAFLESFFGRYVEYNFTADLENQLDDVSGGRDDWRKVLDRFWRDFSGAVDETKDLRVAQVLDALDELLGPHFFPDNGTGHDPRSCPTCNAGRLSLKLGKFGAFIGCSAYPECRFTRPLTTGGEGEEEVREGPKELGNDPESGLPVTLRKGPYGHYVQLGDETTLKAEPAPVPEKGKKAPKTAKAVKAPKPKRVSLYKGLEPAGVTLDIACRLLALPRLVGTHPETGKSISAGVGRFGPYVVHDGVYKSLAKDDDVLVIGMNRAMELLSQAKGRGGSGPLKTLGEHEGKPVTLHEGRYGPYVSRDGVHATLPKDSSIETVTLEAALALIAAKAAKGPAKPVRGRKAAAPKAEAAPKPAAAKKAPAKKKAPTKKKVAAKG
(734) DNA topoisomerase 1 [Acidiphilium cryptum JF-5]
1
MNAIVVVESPAKAKTINKYLGDGFTVLASFGHVRDLPPKDGSVRPDEDFAMSWEEDARGDRQVAAIAKALKGADTLYLATDPDREGEAISWHVRAMLEARNVLKGKQVRRITFNEITKSAVQAALRAPRDLDTPLIEAYLARRALDYLVGFTLSPVLWRKLPGSKSAGRVQSVALRLICEREAEIELFRPREYWTIEAEFRTPAGAPFRARLTHLDGRKLDQFDLADKAAADAAKAAVERGAFSVVSIEKKRVRRNPPPPFTTSTLQQDASRKLHMTAQAIMRTAQQLYEGVEIGGETVGLITYMRTDGVQMAREAITAARQQVKDAFGANYLPAAPREYQSKAKNAQEAHEAIRPTDFTLTPERAARHLSPEQARLYELIYKRALASQMQSAELDQTTVELADAAGTTLRATGSILAFDGFLKLYREGMDEDPEDETARLLPPMAKSDPLASGPVTAEQHFTQPPPRYSEATLVKRMEELGIGRPSTYASILTVLRERNYVRMENRRFIPEDRGRLVTAFLVSFFGRYVETGFTADLEEKLDEVSDGRLDWRSVMRDFWADFSGAVEQIKDLKISDVIDALDEELGPHFFPAREDGSDPRVCQACGTGRLGLRLGRFGAFIGCSNYPECQYTRRLAVEGGEDEGDQLRDGMKLLGENAEGIPVTLRRGPYGLYVQLGEPDPEDKKAKPRRAALPRGMSGETITLEQAIGLLSLPRVIGVHPETKQEIQAGIGRFGPYVKMGPIFASLDKDDDVLAVGLNRAVMVLAKKQEGIRDLGPHPKDGESVTARKGRFGPYVQHGKTVATLPRGSELGAVTLDEAVALLAEKGKTLAPRGRKGAKPAAKPKDAAAPKAARPAKAKAAAKPKAAAAKPEAAAAKAKPAARKTARSGG
(1357) DNA topoisomerase 1 [Rhizobium etli CFN 42]
1
MNVVVVESPAKAKTINKYLGSGYKVLASFGHVRDLPAKDGSVLPDQDFEMLWEVDGASAKRMKDIAEAVKSSDGLFLATDPDREGEAISWHVLDMLNKKRVLNGKSVKRVVFNAITKKAVLDAMADPRDIDVPLVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVCDRESEIERFISEEYWNISALLKTPRGDEFEARLVSAHGKRLPPRAIGNGEDAGRLKALLEGASYIVDTVEAKPIKRNPGPPFTTSTLQQAASSNLGFSASRTMQIAQKLYEGVDIGGETVGLITYMRTDGVQMAPEAIDAARRAILDQFGERYLPEKARFYSTKAKNAQEAHEAIRPTDFNRSPDRVRKFLDADQIRLYELIWKRGIASQMASAEIERTTAEITAENKGEKAGLRAVGSVIRFDGFIAAYTDQKEDGEQSDDGDEDGRLPEINARETLAKQKINSTQHFTEPPPRYSEASLIKKMEELGIGRPSTYAATLATLRDRDYVTIDKRKLIPQAKGRLVTAFLESFFTKYVEYDFTADLEEKLDRISAGELNWKQVLRDFWKDFFAQIEDTKELRVTNVLDSLNEALAPLVFPKREDGGDPRICQVCGTGNLSLKLGRYGAFVGCSNYPECNYTRQLSSENGGEAEGVALNEPKSLGTDPTTGEELTLRSGRFGPYIQRGDGKEAKRASLPKGWKPEDIDYEKAMALISLPRDIGRHPETGKMISSGIGRYGPFLLHDGSYANLETVEDVFSVGLNRAVTLIAEKASKAPGRGARGTPAALKTLGDHPDGGAITVRDGKYGPYVNWGKVNATLPKGKDPQAITIEEALALITEKAGKAPAGKTARGKAKPKAAAAEAKTTKTAAKPKAAKAKAPAKLKKS
(1821) DNA topoisomerase 1 [Candidatus Puniceispirillum marinum IMCC1322]
1
MKVVIVESPAKAKTINRYLGDGYKVLASYGHVCDLPSKDGSVSPENDFEMKWQISSGSEKHLKEITSALKNADKLILATDPDREGEAISWHVLEQLKAKKLVNDMPVERVVFNEVTKSAILTAMDNPRALDEELIDAYRARRALDYLVGFSISPVLWRKLPGSKSAGRVQSVALRLICEREAEIEAFITDEYWSVDTRMAKADGREFTARLTHIDGEKLGKLDIPNEAAAKAAEAKINAADLSVKTIETKRVKRNPSPPFTTSTLQQEASRKLGFSASRTMQIAQRLYEGINIGSDTTGLITYMRTDGVQLGKESIAALRDDIGSRFGNRYLPDSPRIYKTKAANAQEAHEAIRPTDITRDPEAMRSFLDHDQFRLYELIWKRTISSQMQSAELDQTGVDITDPAGTVTLRANGQVMVFDGYLSVYMESQDDKDEKDETRSNLLPEMKEGENLDTQNVSPEQHFTQPPPRFTDASLVKRMEELGIGRPSTYASIIQVLQNRDYVVKDRNRFIPEDRGRLVSTFLGNFFDRYVEYDFTAQLESQLDEVSAGRLDWKALLANFWRDFKSAIDGTKDLTITNVLDVLDEELGPHFFKADENGALMRSCPNCDDGRLGLKLGKFGAFVGCSNYPDCKFTRKLTDSDGTEDDAPVGDKNLGIDPATELPVFLRKGPYGPYVQIGDPETKKPKRASLPKGESAAAIDLDRALSLLALPREVGAHPETGDMIQAGLGRFGPYLKYQGGFTSLPADDDLLTVGINRAVDLLAESAKKKGRVLGAHPAKGDVYVKAGRYGAYVEHNKLRATLPKDVDIADVTLEQAIELLAEKAAKTPAKKPAKKAAAKKKAAPKKKAATKKKATAKKSAKKDS
(345) DNA topoisomerase 3 [Aggregatibacter aphrophilus NJ8700]
10
MRLFIAEKPSLGRAIADVLPKPHQRGDGFIKCGDNDYVTWCVGHLLEQAEPDAYDARFKQWRLEDLPIVPQKWLLIPKKETHKQLKTVEKLVHQAEILVNAGDPDREGQLLVDEVFSYLNLPAEKRNAIQRCLISDLNPSAVEKAIKKLQPNRDFIPLATSALARARADWLYGINMTRAYTIRGRQAGYNGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFFEVLAWVRDPKEETALFSALWQPSKACEDYQDDDGRVLSRALAENVVKRITDQPAKVTDYTDKREKETAPLPYSLSALQIDAAKRFRMSAQEVLDTCQRLYETHKLITYPRSDCRYLPKEHFADRMAVMNAISTHLTPFQPLPEIIDPEQKNRCWNDKKVEAHHAIIPTAKNRAVSLTQAEQNIYFLIARQYLMQFCPDAEYRKCKITLDIVGGTFVAQARNLQIAGWKQLWGKEDNDDEQPDALLPVVKKGQILHCEKGDIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTEAGRILINALPDVATQPDMTAHWESQLDSISRKQASYQQFMQNLTQLLPELLHYINFSALRELSRHNQGVKKTASRTKKS
(96) DNA topoisomerase 1 [Aggregatibacter aphrophilus NJ8700]
9
MSKSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTIGSANGEKAKPISTKGLSLEEKQALKQKKEQDALVKRMGIDPYHGWKANYQILPGKEKVVAELKSLAKKADHIYIATDLDREGEAIAWHLREVIGGDNERFSRVVFNEITKNAIKQAFEHPESLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLIVEREREIKAFVPQEYWEVSVLTDTAKHEQIRLDVVQFKGKKFEPKNAEQAQSAVDFLTKSDYVISDLETKPTSSKARAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMVRGYIEKHYGAPYLPAKPNFYSSKENAQEAHEAIRPSDIHIGSHDLVGMEKDAERLYDLIWRQFVACQMPAAQYDSTTLTVRAGDYTLTAKGRILRFDGWTKVLPQPGKSPEDQALPDVAVNTTLNLLTVEPQQYFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFADLMNYDFTANMEDVLDQIASGTKDWKTELNQFFKDFSKQLSKAELDELEGGMRPNSLVPTDIHCPTCSRNMAIRTASTGVFLGCTGYSLPPKERCKTTINLIPEAELLNVLDDASETKALMERKRCPKCSTAMDSYIIDPHRKLHICGNNPNCDGYLIEEGKFKIKGYDGPIVECDKCGGDMHLKLGRFGKYMACTQCDNTRKILKNGEVAPPKEEPIHFPELRCEKSDAYFVLRDGAGGVFMSAHNFPKSRETRAPKVAELALYRDRLPEKLSYLAEAPQTDPEGNEAIIRFSRKEKRQYVTSEKNGKATKWIVDFVDGKWVERKK
(487) DNA topoisomerase 1 [Gluconacetobacter medellinensis NBRC 3288]
1
MTDVVVVESPAKAKTINKYLGDNYTVLASFGHVRDLPPKDGSVLPDEGFAMKWEADERGSRQIAAIAKALRGAKHLYLATDPDREGEAISWHVRSMLEEKNLLKGIDVQRVTFNEITKSAIKTAMAHPRELDFPLIEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLICEREAEIEVFRPREYWSITARMTTPAGAAFSARLTHLDGHKLDQFDLGDEARAMAAKAAVEAGDYSVDKVERRKVRRNPPPPFTTSTMQQEASRKLGMGAQVAMRTAQQLYEGIDIGGETVGLITYMRTDGVQMAGEAIGAIRGHIGHSFGPEYVPEKARIYSTKAKNAQEAHEAIRPTDVRRTPADMARYLSPEQKKLYDLVWKRSVASQMQSAELDQVAVDITDRQQRVTLRATGSIIAFDGFLRLYSEGRDDSPAKSDDDQDRMLPAMSEHDAIGRGEVAADQHFTQPPPRYSEASLVKKMEEIGIGRPSTYASILTVLRDRNYVQLENRRFVPEDRGRLVTAFLTSFFERYVDTQFTAGLEEQLDDISGGRANWRDVMSAFWSDFSHAVDQTKDLKISDVITALDADLAPYFFPDREDGQDPRVCTACGTGRLGLKLGRYGAFIGCSNYPTCQFTRKLVIDPSKEGEDAATLKDGMRVLGTAPTGEEVTVRRGPWGLYVQQGEPDPEDKKAKPRRATIPRGLDGDKITLVQAVGLLSLPRIVGIHPELGEPIEAGLGRFGPYVKMGAIYGSLDKDDDVLTVGLNRAVDALAKKLASIRTIGPHPKDGEPVMVRKGRFGPYVQHGTIVATVPRGQDMADVTMEEALTLLNEKGKPLKAKGKKATTTRKPAARKTKAKAAEGTEDAGAAPKKKAAPRKAASKAKTATKTTTRKKATPAKAESESD
(1663) DNA topoisomerase 1 [Brucella canis HSK A52141]
1
MGREFRLLYMNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLPAKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVLRQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDGKKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFSASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKPRYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIERTTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALAREKIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYTIIDKRKLIPEAKGRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEVLRDFWRAFSGSVEDIKELRITNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTRQLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLDTVDHEKAIALLSLPRNIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNRAVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKDPASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAEE
Family distribution
Taxonomy tree
Proteobacteria