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Taxon : Gammaproteobacteria
Informations
Name
Gammaproteobacteria
Rank
class
# topoisomerases
356
Lineage and sub-taxa
Lineage
Bacteria
>
Proteobacteria
>
Gammaproteobacteria
Sub-taxa
Topoisomerases
Select all
Name
Family
Sequence
(1016) DNA topoisomerase 3 [Shigella flexneri]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIA
(1727) DNA topoisomerase 1 [Shigella flexneri]
9
MGKALVIVESPAKAKTINKYLGCDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(1015) DNA topoisomerase 3 [Shigella flexneri]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIA
(1033) DNA topoisomerase 1 [Shigella flexneri]
9
MGKALVIVESPAKAKTINKYLGCDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVHKDHALTLVELTPVHHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGRATGWSAFYVDGKWVEGKK
(1211) DNA topoisomerase 3 [Saccharophagus degradans 2-40]
10
MRLFIAEKPSLGRAIADVLPKPHSRGDGFIRCGNGDVVSWCIGHLLEQAEPEAYNPVFKQWRLEHLPIIPDQWQLKPKSKTRKQLTALRKLVKEATCIVHAGDPDREGQLLVDQVIDFLGVKGAKRESVQRCLINDLNPAAVKRSLDTLRSNKEFIPLATSALARSRADWLYGINMTRAYTLQGRKVGYEGLLSVGRVQTPILGMVVERDRAIEEFVSKPFYEVLAHLTTLTGEPTAFTAKWLPSEACEPYMDEDGRVLSKKLAQNVIARITGENGVVEKVDKKAKAQAAPLPYNLSSLQIDAAKRFGFAAQKVLDICQNLYEKHKLITYPRSDSRYLPADHWHQANDVLQAISANVAELVQSVSGANSKLKSKAWNDAKVDAHHAIIPTAKKVSFSSITSEEQKVYSLIARQYVCQFYPKWEYSDTVIHLKIAGGQFVSKARLTHKQGWKVLFERKGGEPNPKDDDEFPSLTLPDLHVGQSVACRQGELLEKQTQPPKYFTDASLLAAMTGIARYVTDPDIKKILKDTDGLGTEATRAGIIELLFKRNFLVRKGKQIHSTPAARGLVAALPSSATTPDMTAQWELVLNAISIREAQYTTFMKPLVASLQTLIAESQRNLPIGLKGVAAKPKAFKRRRKVKAKSV
(543) DNA topoisomerase 1 [Saccharophagus degradans 2-40]
9
MEKSLVIVESPAKAKTINKYLGNKFVVKSSVGHIRDLPTSGGAKSTVDPKERAKQAALTRKMSPEEKAIHREKKSREQLINRMGINPEKNWEARYEILPGKEKVVEELKKLAEEADTIYLATDLDREGEAIAWHLQETIGGDPDRYRRVVFNEITKTAIQKAFEKPSMLDLNRVNAQQARRFLDRVVGYMVSPLLWEKIARGLSAGRVQSVAVRLVAEREREIRAFIPEEYWDIAAQLDTPKGERAGFDVKKYQGNVFRPVNEKEAMEAVERLKASAFKVTSREDKPTQSKPTAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSAEAVETCRGFILDTFGEKYLPEAPISYSSKEGAQEAHEAIRPSDVTRRPDSLTDMERDAQRLYTLIWNQFVACQMTPAQFTSSNIVVTASDYELRARGRVIRFDGFLRVMPAIAKKDEDKILPDVKVGETLNLHQLDPSQHFTKPTARYTEASLVKELEKQGIGRPSTYAAIISTIQDRGYVHVENRRFYADKMGDIVTERLTESFSDLMDYSFTAKMEESLDVVAEGKKDWLSLLNNFYDDFMQKLDAAKAADTGMRRNEPVETNIECTNCGRNMQIRTGTTGVFLGCSGYNLPPKERCKNTMNLVAGEEAVNIDEDDEAESKQLRQKRRCKICNTAMDSYLLDETRKLHICGNNPDCSGYEVEAGSFKIKGYEGPVIECDKCGQDMQLKSGRFGKYFGCTSESCSNTRKLLRNGEAAPPKMDPVKMPELKCEKVDDTYVLRDGASGIFLAASQFPKNRETRAPLVKELLPHKDEIDPKYDFLMKAPLQDNNGLDTIVRYSRKTKEQYVQTEVDGKATGWKAFYEGGKWVISDEQKPKKPAKKAATKTKAKPKAKAKAKKDE
(1126) DNA topoisomerase 3 [Vibrio cholerae O1 biovar El Tor str. N16961]
10
MTRLFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKKWNMADLPIIPEQWQLRPRKSSSQQLTVVRKLLKEATQIIHAGDPDREGQLLVDEVIDYCKVPKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSALARSRADWLYGMNMSRAYTLLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFTLDALIPYQNGTEYFDIRARWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESEQDQTKQAAPLPYSLSALQIDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPKEHLAQAPDVVAAIANNAQEMVTAVNDADLSLRSKAWNDSKVDAHHAIIPTPKKASVNALSGHEMKVYQLIARQYLMQFYPAAIYAEAKLVFNIAGGIFIAKGRQLLSAGWKVLTGQQDEQEECVDKVPPLPVGIVLQCREGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKILRETDGLGTEATRAGILDTLFKRGLLQRDNKLIKSTPAGRGLIHALPSEATYPDMTAHWEHQLQAIAEKGQAYQPFMQTLQGRLEQLIEQVQVAPVPVSLQALPAVSKPAFKRTRRAPKSKARTYKA
(1611) DNA topoisomerase 1 [Vibrio cholerae O1 biovar El Tor str. N16961]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKASTTDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQDFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQPNVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDQILPPVKVGDSLKLVSLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHIVMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECDKCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVLRDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFSRKEKEHYVRTETEGKPSGWMAVYQEGKWLVTDKRKNAK
(442) DNA topoisomerase 3 [Photorhabdus luminescens subsp. laumondii TTO1]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGDNQFVTWCIGHLLEQAEPDAYDNRFARWSLVDLPIIPEKWQLKPRPSVEKQLNIIQTLLEKADEIVHAGDPDREGQLLVDEVLDFLKLDAVRRKNVRRCLISDLNPQAVTRAVDRLRDNRDFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPILGLVVRRDEEIEHFVPKDFFEVKAHIVTPKDERFIAIWQPSESCIDFLDEEGRLIHRPLADHIVTRITGQPAYVISYQDKRESEVAPLPFSLSSLQIEAAKRFGLNAQQVLDICQRLYETHKLITYPRSDCRYLPDEHFAGRHAVLNAISIHATKLLPQELLEIDRKNRCWDDKKVDAHHAIIPTARSSHINLTDSEANIYGLIARQYLMQFFPDAIFRKCVIELEIAGGKFIAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKGDELLCERGEVVERQTQPPKPFTDATILSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKREFLYKKGRHIHATPAGRALIHVLPDMAALPDMTAHWESRLTQISEKQFRYQDFMGPLEETLQQLIWQAKQNRNLTAFRDLPPLPVKDKKGKKIKAPKNTKRAAP
(1735) DNA topoisomerase 1 [Photorhabdus luminescens subsp. laumondii TTO1]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSASQKSSSSSTDKSKKKVKKDEKAVLVNRMGVDPYRGWEANYQILPGKEKVVAELKSLAEKVDHVYLATDLDREGEAIAWHLREVIGGDGDRFSRVVFNEITKNAIKQAFDNPGELNIHRINAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPVEYWQLHADLLAKGEISLHMEVTHQQGKPFKPVNSEQTQAAVSLLEKARYKVLDREDRPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALDMVRDYISDNFGDKYLPEAANTYSSKENSQEAHEAIRPSSVDIVAEQLKDMDVDAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFELRAKGRTLRFDGWTKVMPVLRKGDEDHTLPVVEIGTELDLQQLIPSQHFTKPPARYSEASLVKELEKRSIGRPSTYASIISTIQERGYVRVESRRFYSEKMGEIVTDRLEENFNELMSYDFTARMEDQLDQVASNKVEWKGVLDEFFTDFSEQLDVANKEPEEGGMRPNPMVITSIECPTCQRSMGIRTATTGVFLGCSGYALSPKERCKQTINLIPENEILNVLEGDEAETNALRARRRCKKCGTAMDSYLIDSQRKLHVCGNNPACDSYEVEEGEFRIKGYDGPVIECDKCGAEMHLKMGRFGKYMGCTNETCKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKERLPEKLRYLADAPVVDAEGNKTVIRFSRKTKQQYASSEKNGKATGWSVFYVDGKWVEKDKK
(1061) DNA topoisomerase 1 [Edwardsiella ictaluri 93-146]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKGAASAGDKAKTKAKKNERDALVNRMGVDPYHGWQAHYEVLPGKEKVVSELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDGSRYSRVVFNEITKNAIQQAFSQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEREREIKAFVPEEYWELRADLAVGADVSFQAQVTHYNDKPFKPVNAAQSQAAVTALENARFAVREREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALNMVRAYIGDNFGAEYLPTDANVYASKDNSQEAHEAIRPSDVSVLADDLKGMEADALKLYQLIWRQFVSCQMTAAKYDASTITVQAADYTLKARGRTLRFDGWTRVLPQLRKGDEDRALPAVESGRALDLLQLQPSQHFTKPPARFSEASLVRELEKRGIGRPSTYAAIISTIQDRGYVRTDNRRFYAEKMGEIVTDRLEENFRELMSYDFTAHMEDGLDRVASAQADWKVMLDGFFSDFSQQLEVAEKPPEEGGMRPNPMVLTCIACPTCERQMGIRTASTGVFLGCSGYTLSPKERCKTTINLVPEAEVLNVLEGDDAETNALRAKRRCPKCGTAMDSYLIDNHRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGAEMHLKMGRFGKYMGCTNEACKNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAEAPQQDAQGNATLVRFSRKTKQQYVSSEKDGKATGWTAFFIDGKWVVSEKK
(1169) DNA topoisomerase 3 [Edwardsiella ictaluri 93-146]
10
MRLFIAEKPSLGRAIADVLPKPHRRADGYIQCGDGDVVTWCVGHLLEQAEPDAYDARYARWNLVDLPIVPQKWQLRPKASSAKQLKVIERLLRDAQQVVHAGDPDREGQLLVDEVLDFLALAPEKRRQVQRCLINDLNPQAVARALERLRDNHEFMPLCVSALARARADWLYGINMTRAYTLLGRNAGYNGVLSVGRVQTPVLGLVVRRDEEIAHFVAKDYYEVRAHIVTPSGERFWAQWQPSEACEPHQDEEGRLLNRALAEHVIARIQDKPARVTGYNDKRESEVAPLPFSLSALQIEAAKRFAMSAQQVLDICQRLYETHKLLTYPRSDSRHLPEEHFAGRHAVMAAIATHAPTLANLESVDVQRRNRCWDDNKVDAHHAIIPTARAGGVTLNEDERNIYQLVARQYLMQFCPDAQYRKCVIDLEIEGGGFIAKARFLSQAGWRALLGAKERDDEDEGMPLPVVARDDLLHCERGELMARQTQPPRHFTDATLLSAMTGIARFVQDKSLKKILRATDGLGTEATRAGIIELLFRRGFLHKKGRYIHASQTGSALIHCLPEMAGRPDMTAHWESTLTKISERGCRYQDFMHPLVETLQQLIHQARTAVNPRAFRDLPPIENGRSRRTKGTTASNKRKKA
(1383) DNA topoisomerase [Edwardsiella ictaluri 93-146]
4
MQLYLCEKPSQAKDIARVLGISKRGQGFISADNITVTWAIGHLLEQASPDAYGEQFGKPWRVDVLPVLPDNWKMVVKPQTRDQFTVISKLLKQAGEVIIATDADREGEVIARELLAYCGYRGAVRRLWLSALDEASIREALAGILPGENTAKLYDAGLGRSRADWLIGMNLTRLYTLIARESGVSDVLSVGRVQTPTLAIVVNRDKEIADFVPVPWWQVQVLLEKDGVRFRATWQAAAQYCDDEKRCVNKQAANAVGQLCQQQKGATVLEVSQKRDKTPAPLCFDLGTLQLVCSRKFGMGAKETLAVAQSLYETHKATTYPRTDCGYLPTSMQKEIPEVMGSVAKSDPSVAPVLAQLDRGFVSRVWNDKKITAHHAIIPTRQAFDLSRLSADELKVYQLIRQHYFAQFLPLQESDVTDASFNIGGQLFLAKGKVNVITGWTCLFQKEIQEDPPEDDDMALPALNKGDSCIVNGASVGDKVTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNAGLGTEATRAGVLETLFSRHYLEKKGKHIHATLLARELIAALPETLTSPGMTALWEQALDDIAQGKMSLDTFIQKQLQWTRHLVDKGRADTVKITAPVTPPCPVCKGLTRKRKGKNGDFWGCIRYPECNGIVAGKSGGKGRKIARGKKTVVNTEVELSASQ
(624) DNA topoisomerase 1 [Pseudoxanthomonas suwonensis 11-1]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPERGFAMRYDLIEKNEKHVEAIAKAARSADDIWLATDPDREGEAISWHIAEILKERGLLDGKPLRRVVFTEITPRAIKEAMTQPRTIAGELVDAQQARRALDYLVGFNLSPVLWRKVQPGLSAGRVQSPALRMIVEREEEIEAFKAREYWSIGAELAHAAQPFSAKLVKLDGQKFEQFTITDGESAEAARLRIQQAAAGALHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVTLGEEGTVGLISYMRTDSVNLSQEAVAEIRDVIARDYGTASVPDKPNTYQTKSKNAQEAHEAIRPTSALRTPGSVARFLTDDERRLYELVWKRAVASQMVPATLNTVSVDLAAGSDHVFRASGTTVVFPGFLAVYEEGKDTKTAEDEDEGRKLPPLKPGERVPLDRIHADQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLLFRKYAEMEGRAFRPTDVGRAVSKFLSGHFTRYVDYDFTARLEDELDAVSRGEEEWVPLMERFWAPFKELVEDKKESLDRTDAGSSRSLGIDPKSGKEVSARIGRFGPMVQIGTVDDEEKPKFASLQPGQSIYSISLEDALKLFDMPRNLGESNGQQVSVGIGRFGPFAKRGSTYASLKKEDDPYKIDLARAVELIEEKEEIARNRIIKEFPGSDIQVLNGRFGPYISDGKLNGKIPKDREPSTLTLEEVQQLLAETGKPARRGFGAKKAVARKAATKTAASKEAAPKKALAKKAPAKKAAKKATRKAAAKKAPAKKAAARATADDAPPF
(301) DNA topoisomerase 1 [Francisella tularensis subsp. tularensis SCHU S4]
1
MAKNLVIVESPAKTKTIKKYLGNEFEILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKAAKDAQNIYLATDPDREGEAISWHVQEVLKSARLLKDKNIYRVTFNEITKSAVTNAIANPKELSMDLVDAQKARQALDFLVGFNISPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLLEFNNNKVEQFTFTTAEDAENAKAHILKDANGFLIVDGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIQAKYDKDMLPAKPRVFEKKSQNAQEAHEAIRVTAANRTPESIKQFLTNDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHRFRVTGTVIVDAGFLKIYNVEKDEDEKDSDDEQTLPKFEKGEKIILNDVITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQREYVEVDKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLSVLNNFWHPFIERINKISEDVSRKDVVQEELEEDCPECGSKLSLRLGKNGRFIGCTNYPTCKYTRPVDSDPKEVIKEEPIVVEDRKCPKCNSDLHIKQGRYGKFIGCSNYPECKHMEPLEKPKDTGVVCPKCNKNHIVEKKSRKGKVFYACAGFPKCKNAYWYPPIKEECPKCHSPILLHKITKKDGEQKACPNSECDYAVAFETK
(1619) DNA topoisomerase 1 [Thiomicrospira crunogena XCL-2]
1
MTNLVIVESPAKAKTIEKYLGKGFTVRSSYGHIRDIQKKGMGIDIENGFMPNYEISPDKKKTVTELRKLTKEAETVWLATDEDREGEAIAWHLAEALKLDVNDTKRIVFHEITKTAIQKAIAEPRKVDMDLVEAQQARRILDRIVGFELSPILWKKIRTGLSAGRVQSVAVRLIVEREREIDAFESDYVYRLQGALDILDESQQVVGAVEVKRSAAFKTEEEAQAYLEQVKEAALTVSQLEEKPAKKSPKAPFTTSTLQQEASSKLGFSVKQTMMIAQRLYESGKITYMRTDSVNLSEEAIQKAHDEIVSEFGESYSTTRRYKTKNADAQEAHEAIRPTDFSVKSVTGERNEQRLYQLIWRRAIASQMADAQLKRTNVDIALEGMPAEKLVAKGEVITFDGFLKVYNLDDDAKEGQLPPLKVGQALKLGELLVRQSFSRPPARYNEASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVVKEDREGRQRDYRQLSLTVDGIDASTLTETTGTEKNKLFPTDIAGIVTDFLVKHFGDVLDYKFTALVESEFDTIAQGKESWQEMLTKFYQQFHPRVDAAEDVSREEAGQSRALGNDPKTGKPMFVKIGRFGPYVQLGDGENEEKPTFASLMPGQKMDTLKLEEALELFKLPREVGQMPESFSAKAVDGTEFAVEKGQIIIAKQGPFGPYLEYGPKMYAPIKGFDPLSIELEDAVALIESKIVTEAEKIIKVFPGTDVKILKGRWGPYITDVTTKKNAKIKKDEDALDLSLEECQKRLDEAPEPKKRGRVAAKKKAPAKKAAAKKTTAKKPAAKKPAAKKAPAKKTTRKTPAKKTSDKS
(1545) DNA topoisomerase 1 [Acinetobacter calcoaceticus PHEA-2]
9
MANTSRSASQSTASTAPAAHKRALVIVESPAKAKTINKYLGSQYIVKSSVGHVRDLPTGGSKSTEKKLAARTKLTEAEKEQKASQALVNRMGVDPEHGWEAHYEVLPGKENVVAELKKLAKDADAIYLATDLDREGEAIAWHLREVIGGDDSRYHRVVFNEITKNAIQEAFKQPTRLDLNRVNAQQARRFLDRVVGFMVSPLLWEKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWQVFADTQAKKDDIRLEAVKQAGKTLKLKNKAETDALLDVLKGAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEAGFITYMRTDSTFLSDDAVSMVRAHIENQFGEKYLPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGVERDAQRLYDLIWRQFVACQMTPAEYLSSTLTVEAANVELKAKGRTLVFDGFTRVRGANKSDDDIILPAIKVGEILKLEKLDPSQHFTKPPARFTEASLVKELEKRSIGRPSTYAAIISTIQERGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDKVATGERNWKELLDTFYGDFKKRLTNAQGEHGMRRNQPVEVPAVHCPECSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAALSDDDGAETADLMSKHRCAKCGTAMDSYVIDGGRKLHVCGNNPDCNGFELEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKSGQPAPPRVEPIKMEHLRSTKHDDYFVLRDGAAGLFLAASKFPKIRETRAPKVAELRSVAAQLDPKYQFILQAPDVDPEGNPTVVKFSRKNQSQYVGSETPEGKQTKWSLIYQNGKWVEG
(528) DNA topoisomerase 1 [Pseudomonas aeruginosa NCGM2.S1]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGSSSSKEPAAKGRKSASEAPALSPKEKARRQLVSRMGVDPEHGWKAKYEILPGKEKVIDELRRLAKDADTVYLATDLDREGEAIAWHLREAIGGDESRYKRVVFNEITKKAIQEAFSQPGELDINRVNAQQARRFLDRVVGYMVSPLLWQKIARGLSAGRVQSVAVKLVVEREREIRAFVPEEYWEVHADLGTAKGANVRFEVTREKGEAFKPLNEAQAMAALEKLKASAYSVAKREDRPTSSRPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAIGMVRGFIEDEFGQKYLPGKANVYSSKEGAQEAHEAIRPSDVNLKPTQLSGMERDAERLYDLIWRQFVACQMTPAEYLSTSVSVTAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMKEGENLKLIKLDPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQERGYVTTHNRRFYAEKMGDIVTDRLNESFANLMDYGFTAGMEEHLDDVAQGERDWKHLLDEFYGDFKKKLEVAEVSEKGMRANQPTLTNIPCRECGRPMMIRTASTGVFLGCSGYSLPPKERCKATVNLIPGDEIAADDEGESESRVLRGKHRCPICSTAMDAYLLDEKHKLHICGNNPDCPGYEIEEGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKNGEAAPPKMDAIRMPELKCEKVDDIYVLRDGASGMFLAASQFPKNRETRAPLVSEIIPHKAELDPKYHYLCDAPQKDPDGRPAVIRFSRKTKEQYVQSEVDGKPTGWRAFYDGGKWKVEDKR
(1177) DNA topoisomerase [Pseudomonas aeruginosa NCGM2.S1]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTITWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSVPFWAIDVSLSAEGQAFAAQWVAPDDCTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVGTERVREGPPLLFDLSTLQEVCSRQVGLDVQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSLLNTDPSLRPIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSALSEKELAVYRLIRAHYLAQFLPHHEFDRTVAEFSCGQQTLVATGKQVVVKGWRLVLAEPQADEDGDDTARSQVLPPLREGLACQVAEVEIKALKTMPAKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQLIAQYGCVSLSIKLSHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTPKRGASRSRSSGRKGA
(676) DNA topoisomerase 1 [Pseudomonas mendocina NK-01]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGSASATKEPAKRGKAVAGEAPALSPKEKAKRQLFARMGVDPEHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLRESIGGDDSRYKRVVFNEITKKAIQEAFSKPGELDINRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVAREKEIRAFVPEEYWEVHADLGTAKNAKVRFEVVREGGAAFKPVNEAQAMAALEKLKASSYSVVKREDRPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSNDAVEMVRGFIGSEYGDKYLPGKPNLYSSKEGAQEAHEAIRPSDVNLRPTQLSSMERDAERLYDLIWRQFVACQMPPAEYLSTSVTVAAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMKEGEGLKLIQLDPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVTVHNRRFYAEKMGDIVTERLDESFANLMDYSFTATMEGHLDDVAQGEREWKNLLDEFYGDFKKKLEAAEAGEGGMRANQPTLTDIPCRECGRPMMIRTASTGVFLGCSGYALPPKERCKATINLVPGDEIAADDEGESESRVLLGKHRCPICSTAMDAYLLDETRKLHICGNNPDCTGYEIEQGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPSCKNTRKLLKNGEAAPPKMDKVEMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVLEIVPHKHEIDPKYHFLCDAPQKDPDGRPAVIRYSRKTKEQYVQSEVDGKPTGWRAFYDGGKWKVEDKR
(159) DNA topoisomerase 1 [Pseudomonas brassicacearum subsp. brassicacearum NFM421]
9
MGKSLVIVESPAKAKTINKYLGDQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKAAAGEAPALSPKDKARKQLVSRMGVDPEHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEVHADLGTAKGATVRFDVAREKGEAFKPLNEAQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSVDAVAMARTYIESEFGKKYLPDTPNVYSSKEGAQEAHEAIRPSDANTEPSKLSGMERDAERLYELIWRQFLACQMLPAQYLSTTVSVGAGDFELRAKGRILKFDGYTRVMPQITKPGDDDVLPDMAQGDVMKLIKLDPTQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTERLSESFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFKKKLEVAESPDSGMRANQPVMTDIPCLTCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESLVLRGKHRCPICSTAMDAYLLDEKRKLHICGNNPDCAGYEIEEGTYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKSGDAAPPKMDPVKMPELKCEKVNDTYILRDGASGLFLAASQFPKNRETRAPLVMEIVPHKDEIDPKYHFLCEAPQKDPEGRPAVIRYSRKTKEQYVQTEVDGKPTGWKAFYDGGKWTVQDKS
(56) DNA topoisomerase [Pseudomonas brassicacearum subsp. brassicacearum NFM421]
4
MRLFLCEKPSQGKDIARVLGALRRGNGCYNGPGISVTWCIGHLVEAAPPEAYDERFKRWSLDQLPIVPTNWRVDVKADTAAQYKVVKQLLAKTTELVIATDADREGEMIAREILELCHYQGSIRRLWLSALNEASIRKALTGLRPADETERLYHSALARSRADWLVGMNMSRLFTLLAQRSGHHGVLSVGRVQTPTLRLVVDRDREIERFVPMHYWGIDVHLSYQEQLFLAQWVAPDCATDDAGRCIRQAMAQQALQSVRQAQRAQVLDMQMDRIREAPPLPFDLGTLQEVCSRRFGLGVQQTLEIAQSLYETHKATTYPRSDSGYLPESMWDEASTVLDALIISDPSVEALVQSVNRQQRSRAWNDSKVSAHHGIIPTLEPFQIEALSEKERAVYELIRAHYLAQFLPHHEYDRSCALFTCGGHTLRAHGKQIVASGWHRALAPDSTTSDDDSAQRNQILPPLSTGSDCNVSQVELRTLKTQAPKALTQGELIKAMKGVAKLVTDPRLKRTLKETTGIGTEATRANIISGLLNRGYLYMKGRSVRASDAAFTLIDAVPAAIADPATTAIWEQAFDMIENGQMTLDCFIAKQTAWITQLVEHYRTTTLLIHTPGGPNCPLCGASMRQRQGKHGSFWSCSRYPECKGALPVVTKTTLAPRRRKPRHSKPKGY
(1864) DNA topoisomerase [Pseudomonas brassicacearum subsp. brassicacearum NFM421]
4
MQLYLCEKPSQAKDIAAVLGATRRGDGCWLGPGITVTWCIGHLLETAPPDAYDARYKRWVLADLPIVPAQWKMTVKPKTASQYKAVKRLLGEAKELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDEASIRKALAALKPGAETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPIAYWAIDVQLSHEGTAFTAQWRADPDACDDQERCLNQALARDAAMAMSNAASARTLKVRTERLREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQSLYETYKLITYPRSDCGFLPLSQHSEAPAILAALAQADPSLAPLREHLQPQRKSRAWNDAKVSAHHGIIPTAAARNLDKLAGKQRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKQIVEPGWKRALPEALAPARGREAPAPQTLPALAEGRDCAVDEVKPKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTRQAAWMSKHVARCQGMSLTISGPASPAGRGATPWKNKRKPAKRKAGGAPRKASKAKAT
(1235) DNA topoisomerase [Pseudomonas fluorescens F113]
4
MRLFLCEKPSQGRDIAKVLGASRRGDGCLIGRETTVTWCIGHLLETAPPEAYGDQYKTWSLDHLPIIPAQWRVEVKPKTVAQFKIIKHLLSEATTVVIATDADREGEMIARELLELCNYRGSVERLWLSALNEASIRKALSSLKSSQETFPLYHSALARSRADWLIGMNLSRLFTLLGRRAGYGAVLSVGRVQTPTLRLVVERDRAIASFVSVPYWVVNAHLSSMGQQPFIASWIPPSSGRDEAGRCLQQALASQALQAISSSKTATVVSLRTEHLREAPPLPFDLSTLQEVCSRKLGLGAQETLNIAQALYETHKATSYPRSDCRYLPESMFNEVAAVFDALLRMDPALRPALGSIDQSLRSRAWNDAKVTAHHGIIPTTEPANLGRMSEQERQVYELIRSHYLAQFLPHHEFDRTEVELECSAERLTAVGKQILVQGWKGLLSDNPDDDEPSQKSQVLPALQQGRQCAVDDVELKSMRTAAPKSLTEGDLIKAMKNVAKLVNDPRLKQKLRDTTGIGTEATRAGIIKGLIDRGYLLKKKRALMASATAHTLIEAVPAAVADPGMTAIWEQALDEIEAGRLSLDAFVAKQAHWITQLIANCGALTLSVPVEAGPVCPICNASMLRRKGKSGPFWSCSHYPDCKGTVPISKGIRRP
(411) DNA topoisomerase 1 [Pseudomonas fluorescens F113]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKAAAGEAPALSPKDKARKQLVSRMGVDPEHGWKARYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEVHADLGTAKGATVRFDVAREKGEAFKPLNEAQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSVDAVAMARTYIESEFGKKYLPDTPNVYSSKEGAQEAHEAIRPSDANTEPSKLSGMERDAERLYELIWRQFLACQMLPAQYLSTTVSVGAGDFELRAKGRILKFDGYTRVMPQITKPGDDDVLPDMAQGDVMKLIKLDPTQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTERLSESFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFKKKLEVAESPDSGMRANQPVMTDIPCLTCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESLVLRGKHRCPICSTAMDAYLLDEKRKLHICGNNPDCAGYEIEEGTYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPTCKNTRKLLKSGDAAPPKMDPVKMPELKCEKVNDTYILRDGASGLFLAASQFPKNRETRAPLVMEIVPHKDEIDPKYHFLCAAPQKDPEGRPAVIRYSRKTKEQYVQTEVDGKPTGWKAFYDGGKWTVQDKS
(1122) DNA topoisomerase [Pseudomonas fluorescens F113]
4
MQLYLCEKPSQAKDIAAVLGATRRGDGCWLGPGITVTWCIGHLLETAPPDAYDARYKRWVLADLPIVPAQWKMTVKPKTASQYKAVKRLLGEAKELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDEASIRKALAALKPGAETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVAYWAIDVQLSHEGTAFTAQWRADPDACDDQERCLNQALARDAAQAMANATTARTLKVRTERLREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQSLYETYKLITYPRSDCGFLPLSQHSEAPAILAALAQADPSLAPLREHLQPQRKSRAWNDAKVSAHHGIIPTAAARNLDKLAGKQRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKQIVEPGWKRALPEALAPARGREAPTPQTLPALSEGRDCAVDEVKPKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVTRQAAWMSKHVARCQGMSLTISGPASPAGRGATPWKNKRKPAKRKTSGAPRKPSKAKAT
(1616) DNA topoisomerase [Pseudomonas stutzeri A1501]
4
MTVTWCIGHLLETAPPDAYDPRYKRWVLADLPIVPERWKMLVKPKTASQFKAVKRLLGECRELVIATDADREGEMIARELVEHCRYRGPIRRLWLSALDDASIRKALAALKPGAETFNLYHAALGRSRADWLIGMNMSRLFTLLGRQSGYRGVLPVGRVQTPTLRLVVDRDRSIADFIPVPFWAIDVQLLADGAAFTAQWQAPDDLCDDQGRCLDQARAQQAADAMRNAASARLLKLKTERQREAAPLPFDLGTLQEVCSKKLGLGAQETLDIAQALYETHKLITYPRSDCGYLPLSQLGEARAIVAALTQADPTLAALQPHLDLSRRSRAWNDAKVGAHHGIVPTAAARGLERLAGRPRAVYELIRARYLAQFLPNHEYDRTQADFDCAGQALRAVGKRVVEPGWKRAMPEALAPARGNREAHAPQSLPALQQGQDYAVGEITLKDQQTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQGLLDRGYLVRQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMPLEEFVAKQSAWMSKLVERCAGLRMTISGPPVAAGRNGKPWKKKRSATPRRGSGARTRKPRAAD
(1234) DNA topoisomerase 1 [Pseudomonas stutzeri A1501]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSANKEPVKRGKAAAAEAPALSPKEKAKRQLIARMGVDPEHGWKAKYEILPGKEKVIEELRRLAKEADTIYLATDLDREGEAIAWHLRESIGGDDSRYKRVVFNEITKKAIQEAFSQPGELDLNRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFVPEEYWEVHADLATAQQAKVRFEVAREKGEAFKPLNEAQANAALEKLKGASYSVTKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAISMVRGFIEGEFGDKYLPEKPNLYSSKEGAQEAHEAIRPSDVNLRPNQLSGMERDAERLYELIWRQFVACQMPPAQYLSTSVTVEAGDFELRAKGRILKFDGYTKVMPQQSKAGEDDVLPEMSKGDAMKLLKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVSLHNRRFYSEKMGDIVTERLSESFNNLMDYGFTAGMEEHLDDVAQGERDWKHVLDEFYGDFRKKLEVAESSENGMRANQPTLTDIPCKVCGRPMMIRTASTGVFLGCSGYSLPPKERCKSTVNLIPGDEIAADDEGESESRVLLGKHRCPICSTAMDAYLLDETHKLHICGNNPDCSGYEIEEGQYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNAECKNTRKLLKNGEPAPPKMDAVKMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVRELIPHKDEIDPKYHFLLQAPQQDPDGRPAVIRFSRKTKEQYVQSEVDGKPTGWKAFYDGGKWQVEDKR
(1732) DNA topoisomerase 1 [Pseudomonas syringae pv. syringae B728a]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASAAKDPAAKRGKAAAGEGPVLTPKEKAQRQLVSRMGVDPEHGWKAKYEILPGKEKVIEELRKLAKDADIIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSKPGELDIARVNAQQARRFLDRVVGYMVSPLLWQKVARGLSAGRVQSVAVKLVVEREREIRAFNPEEYWEIHADLGTAKGANVRFEVARENGEAFKPLNETQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAVSMARDYIGTEFGKKYLPESPNVYSSKEGAQEAHEAIRPSDVNTHPSKLTGMERDAERLYELIWRQFVACQMLPAQYLSTTVTVAASDFELRAKGRILKFDGYTRALPQMAKPGDDDVLPDMAQGETLKLNKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTGRLSESFSNLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFRKKLEVAEAADGGMRANQPVMTDIPCKVCGRPMQIRTASTGVFLGCSGYSLPPKERCKATVNLTPGDEIADDDEGESESRVLRGKHRCPICSTAMDAYLLDEKHKLHICGNNPDCTGYEIEEGTYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPDCKNTRKLLKSGDAAPPKMDPVKMPELKCDKVDDTYILRDGASGLFLAASQFPKNRETRAPLVIEIAPHKDEIDPKYHFLCEAPKKDPDGRPAVIRYSRKTKEQYVQTEVEGKPTGWRAFYDGSAWKVEDKR
(422) DNA topoisomerase [Pseudomonas syringae pv. syringae B728a]
4
MRLYLCEKPSQGKDIAAVLGAKTRGDGCIKGNGVAVTWGIGHLLETAPPDAYGEHLKNWSLDTLPILPAEWKVLVKPKTASQFKIVKQLLKQATELVIATDADREGEMIARELIEYCGYRGPIQRLWLSALNEASIRQALNTVKQGSETYPLYLSALARSRADWLIGMNFSRLFTLLGRQAGYTGVLSVGRVQTPTLRLVVDRDRDISNFIPKPFWSVEVQLWTAGQSFLAKWVADEYLVDEEGRCLDQAAAAAALAALKSSQAASTVSVDTKRGKDPAPLPFDLSTLQEVCSAKFGMGVQETLDVAQSLYETHKATTYPRTDCGYLPESMFDEVPMVLDALNRTDPSIGKTLQLIDPEQRSRAWNDKKITGPHHGIIPTLEPANLSAMSEKERKVYELIRAHFLAQFLPTHEYDRTVATFECNAVLLQAVGKRIVIPGWKVLFSASSEEEANDSGGRSQILPVLQIGTRCDVQDLHLKSLKTEPPKAYTEGTLIKAMKTIAKLVKDPRLAQKLKETTGIGTEATRAGTIQGLIDRGSLIKKGSALRATEAAFSLIDAVPPAVADPGTTAIWEQALTMIEQGTLTLDDFIARQSSWITRLVEQYKGTTLSIKVPEGPKCPLCSAKTSQRKGSSGVFWACSRYPECKGTVNIGTGKKKSPGKSAKPRAATVKSS
(655) DNA topoisomerase [Pseudomonas syringae pv. syringae B728a]
4
MRLFLCEKPSQAKDIAAALGATRRGDGCWVGANATVTWCIGHLLETAPPDAYDARYKRWVLEDLPIVPEKWKMLVKPRTASQFKAVKRLLGEATELVIATDADREGEMIARELIEHCRYRGPIQRLWLSALDDASIRKALAALKPGADTFSLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIANFVPAPYWAIDVRLLHDNQAFIAQWRAPSDACDDQDRCLNQALAQQAAQAMRAAASARLVKLRTERIREAAPLPFDLGTLQEICSKKLGLGAQETLDIAQSLYETHKVITYPRSDCGYLPNSQHGEAAGIIAALCKADPALANLSPHLDPQRRSRAWNDSKVTAHHGIIPTAAVRGVERLSGKPRAVYTLIRARYLAQFLPNHEYDRTQADFDCAGHALRAVGKQIVEPGWKRAMPEALAPAKGREAPAPQPLPALFQGCECAVAEVILKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLTKQGKSLCAAPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVAKQAAWMSKQVSRCVGMRMSISGPASPAGVKPPWKKKRKTTTRVAKTATTDTAAKKPRRAVRPAAKA
(959) DNA topoisomerase 3 [gamma proteobacterium HdN1]
10
MKLYIAEKPSLARAIAEALPRPHNRQDSCIQLGNGDCVTWCIGHLLEQAEPDAYDAAYKKWQIAHLPILPEQWQLQPKASTRKQLSALRTLIQSADQLVHAGDPDREGQLLVDEVIHYFKVPAAKRRNMQRLLISDLNPTAVARALTQMRSNQEFTALSTSALARSRADWLYGINMTRAYTLQGQSAGYQGVLSVGRVQTPVLGLVVRRDQVIANFISVPYYEVLAHLLTPAPSETAPSLADPAHPTDSARFTARWQPSEACKPWQDDEGRVLNRALAENVARRITDQPAHVESVEKIPRKLSPPLPYSLSTLQIDAGRRYGMSAQQVLDGCQQLYERHRLITYPRSDSRHLPEDHFAQSNDVLRAIASFGEPLQSACRHANPTLRSKAWDNAKVDAHHAIIPTEKPPQTQSLSDVERKLYEQIARQYVAQFYPAHRYLETQLALRIAGGLFTASARQVQEIGWKTLYARETGHAEDTDALTEIPPLNPGDILHCERGELQEKQTRPPAHFTDASLLSAMTGVSRFVKDPEIRKILKETDGLGTEATRAGIIELLLKRGFVQREGKTLRATPTGTALIEALPESATLPDMTAQWESALEAICQQKIDYHAFIQPLIETLRTLIEQSTQTSPRSFSGLNAPKHTQRTKRKQPAQRFSKRLKSKSPASTGFSKK
(1092) DNA topoisomerase 1 [gamma proteobacterium HdN1]
9
MQKSLVIVESPAKAKTINKYLGKNFIVKSSVGHVRDLPTSGRGETATDSKQRSQKAAATRQLSAAEKEKQKKARAWEALVARMGVDPEHGWKATYQVLPDKQKVVDELRKLAKDCDSIYLATDLDREGEAIAWHLREVIGGDDSRFQRVVFNEITQSAIQEAFASPGRVNENRVNAQQARRFLDRVVGYMVSPLLWAKIGRGLSAGRVQSVAVRLLVEREREIRAFLPEEYWELFAETLTAKKTPLRLEVAREGDKAFRPTDEAQAMAAVKALQHAEYRVANREDKPTRSKASAPFITSTLQQAASTRLGFSVKRTMMLAQRLYEAGYITYMRTDSTNLSAEAVGACREYIEGRYGARYLPDAPNTYASKEGAQEAHEAIRPTDVHLMADQVSGLEKEAQKLYELIWKRFVACQMPPAEYLSTQMTVKAGEFELRAKGRILKFDGHLAVGMPGTRTSDEDIELPDVAVGEVLALKKLDPLRRFTKPPQRFTEASLVRELEKRGIGRPSTYASIISTIQERGYVRVESRRFYAEKMGDIVTDRLSESFDNLMDYGFTARMEEKLDEIAQGNLYWQNVLDEFYSRFSGQLAHAELTEGGMRSNTPVETDIPCPQCGRPMMIRTGATGVFLGCSGYNLPPKERCKGTLNLVPGEEGISATPESDEDESGELEALALRKKHRCKLCATAMDSYLVDEHRKLHVCGNNPDCPGYEVEQGQFKLKGYEGPIVECDKCGSDMQLKTGRFGKYFGCTNEECGNTRKLLRNGEVAPPRESPIPMQHLRCQKHDDFYLLRDGASGLFLAASQFPRHRETRAPTIAELKTVAEQIPEKYQYLLSAPVKDDKGNPAIVRFSRKSREQYVMSESEGKATGWSAVWADGKWVQKPAKE
(1849) DNA topoisomerase 1 [Thioalkalimicrobium cyclicum ALM1]
1
MKNLVIVESPAKAKTIEQYLGKDFVVRSSYGHIRDLSKKGMGIDIPNRFLPSYEVSPDKKKTVTELRKLAKEADAVWLATDEDREGEAIAWHLAEALNLNVAETKRIVFHEITKPAITQAVANPRQVDLNLVNAQQARRILDRVVGFELSPILWKKIRTGLSAGRVQSVAVRLIVEREREIDAFTPVSSFKVSGELYTLNAQGQPDEMLPVKRLAAFDDEASAQAYLASLTGATFSVAQLDQKPAKRSPKPPFTTSTLQQEASQKLGFSVKQTMVIAQRLYESGKITYMRTDSVNLSEVAIGQAKDVITKRFGANYSHPRRYKTKQADAQEAHEAIRPTDFSVTEVGGERNEQRLYQLIWARALASQMSEAELLRSQVDIAIAPSNNELLVAKGEVVTFEGFMKVYNLDGQKDQDVLLPALKVGQNLQPVLLQAKQSFSRAPARYNEASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVIKEDREGSPRAVRLLSWQAGQVKAETLEEITGSEKNKLFPTDIAGIVNDFLVKNFGQVLDFQFTAQVEAKFDQIAMGQQAWQDMLEDFYHKFHPNVELAETLSREEAGQARLLGNDPKTGKPMLVKIGRFGPFVQLGDGENDEKPTFASLKPGQKMDTIKLEEALELFKLPRVLGDMPEAYHAAAADGTPFGVEQGQTITAKQGPFGPYLEYGEKQFAPIKGYDPLSITLEEAVLVIEAKIQADADKIVRSFPSTDVKILKGRWGPYITDTVTKVNAKIAKDEDPMELTLEECQTRLAAAPPPKKRGRAAAAKKPAAKRAPAKKTTTKKVTAKK
(955) DNA topoisomerase 3 [Erwinia amylovora CFBP1430]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGSDQVVTWCVGHLLEQAQPDSYNGRFARWSLADLPIVPEKWRLQPRPSVAKQLNVIKGLLSQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKHAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVAKDFFEVRAHIVTPADERFVALWQPSDSCEPYQDDEGRLLHRPLAEHVVARIGGQPAHVTSYNDKRENETAPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRHLPDEHFAGRHAVLNAINIHLPNLTPPGDFNSDQKNRCWDDKKVDAHHAIIPTARSSQVALSDHERQIYCLIATQYLMQFCPDAIYRKCVIELAIAGGKFLAKARFLAEAGWRALLGSKERDEENDGTPLPVVTRGDELLCERGEVLEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRSFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMSPLVETLHSLIQQARQQPAAYAFRGLPAPATDKTKRPRRKTAQKKESET
(568) DNA topoisomerase 1 [Erwinia amylovora CFBP1430]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGTTVKKSTDSTTSKPTKKVKKDEKTALVNRMGVDPFHGWAANYQILPGKEKVVSELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIRHAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELNADLTTPKGVDLPMQVTHQHDKPFRPINRDQTYAAVSLLEKARYVVVDREDKPTGSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMARGYIEEEFGAKYLPKTANLYSSKENSQEAHEAIRPSDVKVQSEQLKDMETDAQKLYQLIWRQFVACQMMPAQFDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDDRTLPAVEVGSELSLQQLLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNQAQWKAVLDKFFGDFSQQLEQAEKDPEEGGMQPNQMVVTSIECPSCSRQMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCGKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEQGEFRIKGYDGPVVECEKCGGEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPRVEELQRFRDRLPEKLRYLADAPAEDAEGNKAVVRFSRKNKQQYVSTEKEGKATGWSAFYVDGKWEVAKK
(79) DNA topoisomerase 1 [Erwinia tasmaniensis]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPISGSTVKKSTDSTTSKTTKKVKKDAKTALVSRMGVDPFHHWEANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIHQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWDLNADLTTPKGIDLPMQVTHQHDKPFRPVNRDQTYAAVSVLENARFTVVDREDKPTSSKPGAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVSMVRGYVEDEFGAKYLPKTANIYSSKENSQEAHEAIRPSDVKIQSEQLKDMEADAQKLYQLIWRQFVACQMMPAQYDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDERTLPAVEVGSELSLQQLLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNEAQWKTVLDKFFGEFSQQLEQAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCDKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEQGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEDCKNTRKILRNGDVAPPKEDPVPLPELVCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPQVEELQRFRDRLPEKLRYLADAPAEDADGNKSVVRFSRKTKQQYVSTEKDGKATGWSAFFVDGKWEVAAKK
(1269) DNA topoisomerase 3 [Erwinia tasmaniensis]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGGDQVVTWCVGHLLEQAQPDSYNSRFARWSLADLPIVPEKWRLQPRPSVAKQLNVIKGLLEQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKRAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVAKDFFEVRAHIVTPADERFVALWQPSDSCEPYQDEEGRLLHRPLAEHVVARINGQPAHVTSYNDKRENDTPPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINLHQPDLSAPTDFNSDQKNRCWDDKKVDAHHAIIPTARSGQVRLTDNEGQIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFLAKARFLAEAGWRALLGSKERDEENDGTPLPVVAKGDALLCERGEVLEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAQWESTLTKISEKQCRYQDFMSPLVETLHSLIHQARQQPAAHAFRGLPPPASDKVKKTRRKTTKKKESEA
(517) DNA topoisomerase [Erwinia sp. Ejp617]
4
MRLFICEKPSQGRDLAAVLGATQRGDGFLAGSGITVTWAVGHLLETAPPEAYGQQYGKPWTLAALPIIPSPWQVVVKKETQHQFKIIERLLRQVDEVIIATDADREGEVIARELLDYCRWEGPVQRLWLSSLDELSIRAALQNLRPGGETLGMYHAGLGRARADWLTGMNLSRLYTLRAAEAGFDGVVSVGRVQSPTLALVVRRDREIAAFVPKPYWQVKAQLSAGGITFPAQWVPAKVYTDEEKRCIHQNIAQQVVQICRQSGEATVTECETKREKASPPLAFSLGTLQQAASRLWDMSPQQVLDTAQSLYEKHKATSYPRTDCGYLPESMREEIPALLDAIGRTDPECLPLLSQLDASLVSRIWNDKKITAHHGIIPTRNAFQLSALSETERQVYMLIRRNYLAQFLPLHESDITRLAFDIGGQLFRTTGRTEVVKGWKVLFGKAEEEGSAADDEAVVALPPLKKDDRCGVTGAEVVQLMTRPPAHYTFATLIGAMMNAAAFVTDVALRKVLKDNAGLGTEATRAGIVEQLLNRRFIVRKSSKLLATDLGSDVIDSLPPQLTEPGMTALWEQALDEVAAGRMSLSDFLQRQTGWTRNLVSQGAQQQVSIRIPPTPPCPLCGGKTRLRKGQKGDFWSCQRYPDCKGVINIGSGKRKSPRKAKSPKPNKN
(407) DNA topoisomerase 3 [Erwinia sp. Ejp617]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGSDQVVTWCVGHLLEQAQPDSYNSRFARWSLDDLPIVPEKWRLQPRPSVAKQLNVIKGLLTQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKRAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVAKDFFEVRAHIVTPADERFVALWQPSASCEPYQDEEGRLLHRPLAEHVVARIGGQPAHVTSYNDKRENETAPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINVHQPNLSPPGDFNSDQKNRCWDDKKVDAHHAIIPTARSSQVSLSDNEQQIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFVAKARFLAEAGWRALLGSKERDEENDGTPLPVVTKGDELLCERGEVQEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMSPLVDTLHSLIQQARQQPAAHAFRGLPASATDKTKRPRRKTAQKKESET
(377) DNA topoisomerase 1 [Erwinia sp. Ejp617]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTVKKSADSTTSKTTKKVKKDEKTALVNRMGVDPFHGWEANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIRQAFDRPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVDREREIKAFVPEEYWELNADLTTPKGVDLPMQVTHQHDKPFRPINREQTYAAVSLLEKARYVVVDREDKPTGSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMVRGYVEEEFGAKYLPKTANLYSSKENSQEAHEAIRPSDVKVQSEQLKDMEADAQKLYQLIWRQFVACQMVPAQFDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDDRTLPAVEVGSELSLQQLLPGQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNEAQWKAVLDQFFGDFSQQLEQAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALSPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCGKCGTAMDSYLIDNQRKLHVCGNNPECDGYDIEQGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPQVEELQRFRDRLPEKLRYLADAPAKDADGNKAVVRFSRKTKQQYVSTEKDGKASGWSAFYVDGKWEVTKK
(437) DNA topoisomerase 1 [Moraxella catarrhalis RH4]
9
MATSKKTTTKAEAALTKANARGKSLVIVESPAKAKTINKYLGKDYVVRSSVGHVRDLPVGGSATKTNKTQDVGLSREEKAQKALVRRMGVDPEHDWAAVYEILPNKTKVIRELKALAKEADKIYLATDLDREGEAIAWHLKEVIGGSDDKYSRVVFNEITKTAIQTAFEHPDQLNIDRVNAQQARRFLDRVVGFMVSPLLWAKIARGLSAGRVQSVATRLVVEREREIRAFVPVEYWKIHTNNTAAGETLNLEAVKKNGKTLKLGNKAQADEVVLALGSSDFIVSAIEEKPTQSRPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSQDALNLVREYITDHFGDDYLPQKPNFYGNKQNAQEAHEAIRPSHVLVKSSQLTGMERDAQRLYELIWRQFVACQMMPARYQSVNLMVAAGDIELKAKGRTLVFDGYTKVQPPAKTDDILLPAVKVGEKLPLIEILPTQHFTSPPARYSEASLVKELESLGIGRPSTYASIISTIQERGYVKLENKRLYAEKMGDIVTERLVESFPDLMDYAFTAGLEDKLDEVAVGEEDWKTVLDRFYHDFKQKLDYAKTTDGMRPNNPTNVPDIHCDLCHRPMQIRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVSAFEFDADDDSAEVNALMEKKRCPKCNTAMDGYIVDGGLKLHICGNNPDCDGHVLEKGVFEIGGATSDTPTIDCDKCDGQMELKTGRFGAYFACRKCDNTRKVLKNGQAAPPRMTPIDMPKLRSQKFDDHYVLREGAAGLFLAASKFPKVRETRPPKLSELREIKDQLEPKFYYLFDAPDTDDVGNPTILRWSRKNQEQYVGSEKDGKATRFALVWRDGAWVQA
(438) DNA topoisomerase 1 [Moraxella catarrhalis RH4]
9
MATSKKTTTKAEAALTKANARGKSLVIVESPAKAKTINKYLGKDYVVRSSVGHVRDLPVGGSATKTNKTQDVGLSREEKAQKALVRRMGVDPEHDWAAVYEILPNKTKVIRELKALAKEADKIYLATDLDREGEAIAWHLKEVIGGSDDKYSRVVFNEITKTAIQTAFEHPDQLNIDRVNAQQARRFLDRVVGFMVSPLLWAKIARGLSAGRVQSVATRLVVEREREIRAFVPVEYWKIHTNNTAAGETLNLEAVKKNGKTLKLGNKAQADEVVLALGSSDFIVSAIEEKPTQSRPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSQDALNLVREYITDHFGDDYLPQKPNFYGNKQNAQEAHEAIRPSHVLVKSSQLTGMERDAQRLYELIWRQFVACQMMPARYQSVNLMVAAGDIELKAKGRTLVFDGYTKVQPPAKTDDILLPAVKVGEKLPLIEILPTQHFTSPPARYSEASLVKELESLGIGRPSTYASIISTIQERGYVKLENKRLYAEKMGDIVTERLVESFPDLMDYAFTAGLEDKLDEVAVGEEDWKTVLDRFYHDFKQKLDYAKTTDGMRPNNPTNVPDIHCDLCHRPMQIRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVSAFEFDADDDSAEVNALMEKKRCPKCNTAMDGYIVDGGLKLHICGNNPDCDGHVLEKGVFEIGGATSDTPTIDCDKCDGQMELKTGRFGAYFACRKCDNTRKVLKNGQAAPPRMTPIDMPKLRSQKFDDHYVLREGAAGLFLAASKFPKVRETRPPKLSELREIKDQLEPKFYYLFDAPDTDDVGNPTILRWSRKNQEQYVGSEKDGKATRFALVWRDGAWVQA
(203) DNA topoisomerase 1 [Psychrobacter sp. PRwf-1]
9
MAKTTAKKTTSTPAASAKGKSLVIVESPAKAKTINKYLGDDFIVRSSIGHVRDLPTSSGVKKKATKTDEKLSKEDKAQQALVRRMGIDPEHGWKAVYEVLPNKTKVIKELKALAKDADKIYLATDLDREGEAIAWHLREVIGGDDSKYQRVVFNEITKSAIQNAFKEPGKLDIDRVNAQQARRFLDRVVGFMVSPLLWQKIARGLSAGRVQSVATRLVVEREREIRAFIPEEYWQIHADTTMKGSENANVAADTPIRLEAVKQAGKVLKLGNKAQTDAVLAVLKPATFVVKEREEKPTQSKPSAPFITSTLQQAASTRLGFPVKKTMMLAQRLYEAGHITYMRTDSTFLSNDALASVRGFIEENYGSKYLPEKPNFYGSKQNAQEAHEAIRPTNANLKSTQLKGVDRDAIRLYELIWRQFVACQMLPAKYKSVNLLVEAGDVELKARGRTMTFDGFTKVMPPAKTDDTLLPDVKQGDELNLIKLDPSQHFTKPPARYTEASLVKELEKKGIGRPSTYASIISTIQDRGYVRLENKRLYAEKMGDIVTDRLTESFPELMDYTFTAGLEDELDHVAQGDQDWKAVLDDFYGDFKTKLEHAKDKDGMRPNDPTDVPDVHCDLCGRPMQLRNGSTGVFLGCTGYNLPPKERCKGTKNLMPVEAFANLDDSEIDESAEVKELMEKKRCPKCSTAMDGYIVDGGLKLHICGNNPDCDGYLLEEGMFEVPGSDAPTIDCNKCDGQMELKTGRFGPYFACNKCDNTRKVLKNGEPAPPRMDPIDMPELKSTKHEDHFILREGAAGLFLAASKFPKVRETRPPKLSELRTIKDKMDDKFQYLFDGPDQDPEGNPTILRWSRKQKEQYIGSESLKTGKATRWGVYWRKGEWVEE
(826) DNA topoisomerase 1 [Psychrobacter cryohalolentis K5]
9
MTKPAAKKSAAPAADKPKGSPKASPKGKSLVIVESPAKAKTINKYLGDDFIVRSSIGHVRDLPVGASKSAKKPATTKKDDSLSKEEKTQQALVRRMGVDPEHDWAAVYEVLPNKTKVIKELKALAKDADKIYLATDMDREGEAIAWHLKEVIGGADSKYERVVFNEITKSAIQNAFKQPSKLDIDRVNAQQARRFLDRVVGFMVSPLLWQKVARGLSAGRVQSVAMRLVVEREHEIRAFIPEEYWQIHADTHIADSKAKKAADAEQIGIRLEATKQGGKTLKLVNKEQTDKVLDVLKANDFIVKEREEKPTQSKPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSGDALAAVRGYIEDSYGAKYVPEKPNFYGNKQGAQEAHEAIRPSNVNMKSTQLKAVERDAIRLYELIWRQFVACQMLPAKYLSVNLFVAADDVELKARGRTLVFDGFTKVMPPAKTDDNLLPDVKKGDKLILDKLDPSQHFTKPPPRFTEASLVKELEKKGIGRPSTYASIISTIQDRGYVKLENKRLFAEKMGDIVTDRLTASFPDLMDYTFTAALEDKLDHVAEGDTDWKDVLDNFYGDFKTTLDRAKEKDGMRPNDPTDVPDVHCDLCARPMQLRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVEAFANLDDAEGDDEAAEVRDLMEKKRCPKCGTAMNGYIVDGGLKLHVCGNNPDCDGYVLEEGKFEVPGSDSPTIDCNKCDGQMELKTGRFGPYFACQQCDNTRKVLKTGEAAPPRMDPIHLPELKSVKHEDYFILREGAAGMFLAASKFPKVRETRPPKLAELREIKDKMEDKFQYLFEGPDEDPDGNPTILRWSRKKKEQYIGSEKNGKATRWGVYWRKGEWVEE
(1437) DNA topoisomerase 1 [Francisella sp. TX077308]
1
MAKNLVIVESPAKTKTIKKYLGNNFDILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKSAKNAENIYLATDPDREGEAISWHVQEVLKNARLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVNAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFVKKDYWSLTADIFKQKQIFANLTEFDGTKVEQFTFTAEKDAENAKATITKDANGFLIVEGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGMDLGNGESVGLISYMRTDSTNLSNDALNDIRSFIESKFDKDMLPSKPRVFGKKSQNAQEAHEAIRVTSASKTPESMKPYLTTDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENEKHKFRVTGTVIVDAGFLKIYNVEKDEDEKESNDEQTLPKFEKGEKVPLKDIITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQRDYAEVEKRRFIPTDKGRVVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLTVLNSFWKPFIERINKIAEDVSRKDVVQEELDEDCPECGSKLSSRLGKNGRFIGCTNYPTCKYTRRVDSDGKEIEKEEPTVVEDRKCPECGSNLHIKQGRYGKFIGCSNYPTCKHMEPLEKPKDTGVVCPKCNKNNIVEKKSRKGKVFYACSGFPKCKNAYWYPPIKEECPKCKSPILLHKTTKKDGEQKACPNPECDYAVPWEENK
(1698) DNA topoisomerase 3 [Enterobacter aerogenes KCTC 2190]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDGRYARWNLLDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQDERFIATWVPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPAIVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAISVHAPDLLPQPVMDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLNDNEEKVYNLIARQYLMQFCPDAVFRKCQIDLDIANGKFVAKARFLAEAGWRALLGNKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRGFLNKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFQLIDQARSTPVRQFRGLVAPGGAKKSFSKGKGKPKGKKPEADIAPESPQ
(1358) DNA topoisomerase 1 [Enterobacter aerogenes KCTC 2190]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERGALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPGGDALPLQVTHKNDKPFRPVNRDETMAAVALLEKALYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGDNFGKKYLPENANQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGEFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPVVNQGDNLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRAENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKQVLDNFFGDFTSQLQTAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFFIDGKWTEAKK
(862) DNA topoisomerase 1 [Acinetobacter oleivorans DR1]
9
MANTSRSASQSTASTAPAAHKRALVIVESPAKAKTINKYLGSQFIVKSSVGHVRDLPTGGSKSTEKKPAARTKLTEAEKEQKASQALVNRMGVDPEHGWEAHYEVLPGKENVVAELKKLAKDADAIYLATDLDREGEAIAWHLREVIGGDDSRYHRVVFNEITKNAIQEAFKQPTRLDLNRVNAQQARRFLDRVVGFMVSPLLWEKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWQVFADTQAKKDDIRLEAFRQAGKTLKLKNKAETDALLDVLKGAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEAGFITYMRTDSTFLSDDAVSMVRAHIESQYGEKYLPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGVERDAQRLYDLIWRQFVACQMTPAEYLSSTLIVEAANVELKAKGRTLVFEGFTKVRGANKSDDDIILPAIKVGEILKLEKLDPSQHFTKPPARFTEASLVKELEKRSIGRPSTYAAIISTIQERGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDKVATGERNWKELLDTFYGDFKKRLTNAQGEHGMRRNQPVEVPAVHCPECSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAALSDDDGAETADLMSKHRCAKCGTAMDSYVIDGGRKLHVCGNNPDCDGFELEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKSGQPAPPRVEPIKMEHLRSAKHDDFFVLRDGAAGLFLAASKFPKIRETRAPKVAELRSVAAQLDPKYQFILQAPDVDPEGNPTIVKFSRKNQSQYVGSETPEGKQTKWSLVYQDGKWVEG
(717) DNA topoisomerase 3 [Klebsiella variicola At-22]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLTDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVATWVPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPALVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADLLPQPVMDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLTDNEAKVYHLIARQYLMQFCPDAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSSDAGRALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFQLIDQARSTPVRQFRGLAAPGGAKKSFSKGKGKPKGKKAADDAAPPPQ
(972) DNA topoisomerase 1 [Klebsiella variicola At-22]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSTDSTATKGAKKPKKDERGALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVIHKDDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDNFGKKYLPESANQYASKENSQEAHEAIRPSDVSVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPVVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLETAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVASEKEGKATGWSAFFIDDKWTEAKK
(160) DNA topoisomerase 1 [Acinetobacter sp. ADP1]
9
MANAPRSTTKKSTTASSEPAGNKRALVIVESPAKAKTINKYLGSQYIVKSSVGHVRDLPTGGSAKSGEKKPATRAKLTAEEKEQKAQNALINRMGVDPEHDWKAHYEVLPGKEHVVAELKKLASQVDEVYLATDLDREGEAIAWHLKEVIGGDDSRYQRVVFNEITKNAIQEAFKHPARLDTNKVNAQQARRFLDRVVGFMISPLLWEKIARGLSAGRVQSVAVKLVVERERDIRAFIPEEYWQIFADTLSKKDQIRLEAVKQAGKTLKLRNKADTDAVLNLLKDAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEGGFITYMRTDSTFLSDDAVNMVRDHIQQQFGDKYVPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGMERDAQRLYDLIWRQFVACQMTPAEYLSSTLIVDANNVELRAKGRTLVFDGFTRVRGANKSDDDVLLPAVKVGETLKLEKLDPSQHFTKPPARFTEASLVKELEKRGIGRPSTYAAIISTIQDRGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDKVATGERNWKELLDSFYGDFKNRLNMAASTEGMRRNQPVEVPDVACQLCSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAAFSDDDSAETADLMAKHRCAKCGTAMDSYVIDGGRKLHVCGNNPDCDGYEVEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKSGQPAPPRVDPIKMEHLRSVKHDDYFVLRDGAAGLFLAASKFPKIRETRAPKVAELRTVAEQLDPKYQYLLQAPDADPEGNPALIKFSRKNQAQYVGSETPEGKQTKWSLVYQDGKWTEA
(1489) DNA topoisomerase 1 [Acinetobacter baumannii ATCC 17978]
9
MANTSRSASQSTASSASAAHKRALVIVESPAKAKTINKYLGSQYIVKSSVGHVRDLPTGGSKATEKKPAARTKLTEAEKEQKANQALINRMGVDPEHGWQAHYEVLPGKENVVAELKKLAKDADAIYLATDLDREGEAIAWHLREVIGGDDSRYHRVVFNEITKNAIQEAFKQPTRLDLNRVNAQQARRFLDRVVGFMVSPLLWEKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWQVFADTKAKKDDIRLEAVKQAGKTLKLKNKAETDALLDVLKGAEYKVAQREDKPTKVNPSAPYITSTLQQAASTRLGFSVKKTMMLAQRLYEAGFITYMRTDSTFLSDDAVSMVRAHIESQYGEKYLPAKPNRYGNKAGAQEAHEAIRPSNVALTGDQLAGVERDAQRLYDLIWRQFVACQMTPAEYLSSTLTVEAGNVELKAKGRTLVFDGFTKVRGANKSDDDIILPAIKVGEILKLEKLDPSQHFTKPPARFTEASLVKELEKRGIGRPSTYAAIISTIQERGYVKLENRRLFAEKMGEIVTDRLDESFNNLMNYAFTADLEGQLDRVATGERNWKELLDTFYGDFKKRLTNAQGEQGMRRNQPVEVPAVHCPECSRPMQIRTGTTGVFLGCSGYNLPPKERCKGTLNLTPVESLAALSDDDSAETADLMSKHRCPKCGTAMDSYVIDGGRKLHVCGNNPDCDGYELEEGEFKIKGYDGPTIPCDKCDGEMQLKTGRFGPYFACTSCDNTRKVLKNGQPAPPRVEPIKMEHLRSTKHDDYFVLRDGAAGLFLAASKFPKIRETRAPKVAELRSVADQLDPKYQFILQAPDVDPEGNPTIVKFSRKNQSQYVGSETPEGKQTKWSLIYQDGKWIEG
(1590) DNA topoisomerase 3 [Klebsiella pneumoniae KCTC 2242]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDIYDSRYARWNLNDLPIVPEKWQLQPKPSVTKQLNVIKRLLGEAQEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVATWVPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPAIVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADLLPQPVVDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLTDNEAKVYTLIARQYLMQFCPDAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCERGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLSKKGRYIHSSEAGRALIHSLPEMAGRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQARSTPVRQFRGLVAPGGAKKSFSKGKGKPKGKKAADDTAPPPQ
(730) DNA topoisomerase 1 [Klebsiella pneumoniae KCTC 2242]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTATKGAKKPKKDERSALVNRMGVDPWHDWNAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVTHKDDKPFRPVSRDETMAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYISDKFGKKYLPDSANQYASKENSQEAHEAIRPSDVNVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPLVKQGDRLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKEVLNHFFGDFTTQLATAEKDPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVASEKEGKATGWSAFFIDGKWTEAKK
(1417) DNA topoisomerase 3 [Enterobacter asburiae LF7a]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLNDLPIVPEKWRLQPRPSVTKQLNVIKRFLHEASEVIHAGDPDREGQLLVDEVLDYLELAPEKRQQVQRCLINDLNPQAVERAISRLRANSEFIPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPKEERFTATWQPSDACESYQDEEGRLLHRPLADHVVNRITGQPAIVTSYNDKRESEPAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHYAGRHSVMNAIGVHAPDLLPQPAVNPDTRNRCWDDKKVDAHHAIIPTARTSNVNLTENESKVYNLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLEKKGRYIHSTEPGRALIHSLPELAARPDMTAHWESILTQISEKQCRYQDFMQPLVGTLYQLIDQARSTPVKTFRGMVAPGGGAKKPFKKKKSAA
(1116) DNA topoisomerase 1 [Enterobacter asburiae LF7a]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERSALVNRMGVNPWHNWDAQYEVLPGKEKVVNELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDANVTTPGGDALPLQVSHQNDKPFRPENREQTMAAVALLEKARYQVLEREDKPTSSKPGAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESANQFASKENSQEAHEAIRPSDVSVLAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDELSLVDLVPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEANFRELMNYDFTAQMEDSLDQVASHQAEWKKVLDSFFSDFTNQLDKAEKDPEEGGMLPNQMVLTSIDCPTCGRKMGIRTATTGVFLGCSGYALSPKERCKTTINLVPENEVLNILEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKEGKATGWSAFFVDGKWAEGKK
(1591) DNA topoisomerase 3 [Enterobacter lignolyticus SCF1]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLTDLPIVPEKWQLQPRPSVTKQLNVIKRLLQDASEVIHAGDPDREGQLLVDEVLDYLNLAADKRQQVQRCLINDLNPQAVERAISRLRANSEFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPADERFTALWQPSEACEPYQDEEGRLLHRPLADHVVSRISGQPAMVTAYNDKRESEPAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRQAVLNAISVHAPDLLPQPAVDPEVRNRCWDDKKVDAHHAIIPTARSSSVKLSDNEANVYGLVARQYLMQFCADAVYRKCQIDLDIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVEKGAELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLVKKGRYIHSTEAGRALIHSLPEMAGRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLFSLIDQARRTPVKQFRGLVAPGGDKKKTFARKGGKRKTAAE
(755) DNA topoisomerase 1 [Enterobacter lignolyticus SCF1]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSATKKSADSASTKTAKKPKKDERGALVNRMGVDPWHDWKAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDTRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFVDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPSGEVLPLQVSHYLDKPFRPVTRDETMAAVSLLEKARYSVVEREDKPTSSKPGAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALNMVRGYISDSFGKKYLPESANQYASKENSQEAHEAIRPSDVNVMAEALKDMETDAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDYKLKARGRTLRFDGWTKVMPALRKGDEDRTLPPVKQGDALSLVELQPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKEVLNDFFGDFTRQLETAEKGPEEGGMQPNPMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCAKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELHRFRDRLPEKLRYLADAPQEDGQGNKTMVRFSRKTKQQYVASEKDGKATGWSAFFVDGKWQEAKK
(947) DNA topoisomerase 1 [Enterobacter sp. 638]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSASKKSADSTSTKGAKKPKKDERSALVNRMGVDPWHEWEAQYEVLPGKEKVVNELKQLAEKADHIYLATDLDREGEAIAWHLREIIGGDETRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANVTTPAGDALPLQVTHENDKPFRPVNRDHTMAAVAQLEKARYQVVEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVTMVRDYIGENFGKKYLPESANQYASKENSQEAHEAIRPSDVSVVSESLKDMETDAQKLYQLIWRQFVACQMNPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPPVNKGDELSLTELLPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRAENRRFYAEKMGEIVTDRLEANFRELMNYDFTAQMEDRLDQVANHQAEWKNVLDSFFSDFTEQLAKAEKDPEEGGMQPNQMVLTSIDCPTCSRQMGIRTATTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLRMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPLQDPEGNKTVVRFSRKTKQQYVSAEKEGKATGWSAFFIDGKWVEGKK
(224) DNA topoisomerase 3 [Enterobacter sp. 638]
10
MRLYIAEKPSLARAIADVLPKPHRKGDGFIECGKGQVVTWCIGHLLEQAQPDVYDSRYARWNLNDLPIVPEKWRLQPRPSVTKQLNVIKRFLHDAAEIVHAGDPDREGQLLVDEVLDYLELAPEKRKQVQRCLINDLNPQAVERAISRLRSNNEFIPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPKDERFVAVWQPSEACEPYQDEEGRLLHRPLAEHVVNRIAGQPAIVTSYNDKRESEPAPLPFSLSALQIEAGKRYGMSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIGVHTPDLLPQPAVNLETRNRCWDDKKVDAHHAIIPTARASNVNLTENESKVYQLVARQYLMQFCADAMFRKCVIELEIAKAKFVAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKNDELLCEKGEVIERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLIKKGRYIQSTDPGRALIHSLPELAARPDMTAHWESILTKISEKECRYQDFMQPLVGTLFDLINQARTTPVKNFRGMVAPGGAKKPFKKKKSAA
(1627) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhi]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLSVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(150) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(148) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(1628) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhi]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLSVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(149) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(94) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(1228) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(196) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Newport str. SL254]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(1239) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Newport str. SL254]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFMLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1332) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
10
MANWSRPAAVALWLRFVNLMRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAKETGRQTE
(896) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQLLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(500) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
7
MDLYICEKPSQAKDLAGVMKASQRGDGFIHDGGNRVITWAFGHLLELYMPDDYDERYKSWSLETLPIAPDAWRYNVRKSALKQYKIVEGLVKKASTIYISTDFDREGEAIARSLLDQFRYSGPIRRVCLTALDESSIKKALNNVKDGKETVSLYYAALARQRADWLVGMNVSRLYTVLARDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEECSDEQGRCINKAYAEQVSSQVNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGYTAQQVLDAAQALYETHKATTYPRTDSRYLPESQKENIPDILQALILSDQNVSGLVAGADPHRKARVFNDSKVTAHHAIIPTPARTDISAMSEIELNLYDAIRRFYIAQFYSEFEFTKTSIEVQCGRHLFAASGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALLNGTELMNKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGTVDKGYFKRQKKVLLATDKAHALIAVLPPAIKSPGMTAAWEQELEKVATGSGNMSVFMKQISTWICQMVDQLKVAAPVLTKEGSAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQNEACKKTFPDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTMPFKKSDL
(316) DNA topoisomerase 3 [Xenorhabdus nematophila ATCC 19061]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIECGNNQFVTWCVGHLLEQAEPDAYDSRYARWVLTDLPIIPEKWQLKPRPAVAKQLNTIKSLLERASEIVHAGDPDREGQLLVDEVLDFLDLDAEKKQNVQRCLINDLNPQAVIKAVERLRNNREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFVPKDFFEVKAHIVTPSEERFTAIWQPSESCIDFQDEEGRIIHRPLAEHVVARITGQPAIVTAYQDKRESETAPLPFSLSSLQIEAAKRYGLSAQDVLDICQRLYETHKLITYPRSDSRYLPEEHFTGRHAVLNAISVHAAHLLPQDALDTERKNRCWDDKKVDAHHAIVPTARSSQVNLTKNENDIYSLIARQYLMQFFPDAIFRKCTIELDIAGGKFIAKARFLAEAGWRTLLGHKERDEENEGTPLPIVAKGDELLCEKGEMVERQTQPPRPFTDATLLSAMTGIARFVQDKALKKVLRATDGLGTEATRAGIIELLFRREFLYKKGRHIHATPAGRALIHVLPDMAVLPDMTAHWESRLTQISEKQFRYQDFMSPLQETLQQLIRQAKQYRNLKAFRDLPPVPAKGKKGKQLKSSKSKNR
(549) DNA topoisomerase 1 [Xenorhabdus nematophila ATCC 19061]
9
MAKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGAASQKSSISSTDKNKKKVKKDEKTALVSRMGVDPYHDWEANYQILPGKEKVVAELKTLAEKAEHVYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAITQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWQLHADLVAKGEIALRMEVTHEKGKPFKPVNAQQTHAAVSLLEKAKYSVIDREDRPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALDMARGYISTHFGDKYLPKEGNVYSSKENSQEAHEAIRPSNVEVMAEELKDMEADAQKLYQLIWRQFIACQMMPAKYDSTTLTVQAGNFELRAKGRTLRFDGWTKVMPVLRKGDEDNTLPAIEANTELDLQQLFPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVHVENRRFYAEKMGEIVNDRLEENFNELMSYDFTARMEDQLDHVANNEANWKGVLDEFFSNFSEQLDVASKEPDEGGMRPNPMVITSIDCPTCCRAMGIRTATTGVFLGCSGYALSPKERCKQTINLIPENEILNILEGDDAETNALRARRRCKKCGTAMDSYLIDNQRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGSEMHLKMGRFGKYMGCTNEECKNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLHYLAEAPVADPEGNKTVVRFSRKTKQQYVSSEKNGKATGWAAFFVEGSWAVKEK
(1543) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGGSITVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILPGEQTESLWQAGLGRARADWLTGINLTRLYTLKAQEQGFGEVLSIGRVQTPTLALVVNRDNDIARFEQKPYWQVMATLQKDDISFRAKWLPAPDDGDEEKRCIREDIAQRVVQRCQQAQDAVVTELTQKREKTPPPLCFDLGTLQQVASRQWGMGAGQVLTIAQSLYETHKATTYPRTDCGYLPVSMRENIPAVFTALTRTDPAMSAIISQLDASAFSRVWNDSQITAHPAIIPTRHTFDMTKLTADELKVYQLIRHYYLAQFLPAQETDVTDVTFTIGGQVFQAKGRVSVVTGWKALFADEKQAQEQEDNTALPALKKEEISPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRESAGLGTEATRAGIIEALFKRRLLARKKKNLHATQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRRGNSPD
(1717) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
4
MQLYLCEKPSQARDIARVLGVKQRGQGYLFGDSIIVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCHFTGPVRRLWLSALDETSIRQALAAILPGEKTAPLWQAGLGRARADWLTGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMATLQKDDISFRAKWLPAPDDGDEEKRCIREDIAQSVVQRCQQTQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYETHKATTYPRTDCGYLPVSMRENIPAVFTALTRTDPAMSAIISQLDASAFSRVWNDSQITAHPAIIPTRHTFDMTKLTADELKVYQLIRHYYLAQFLPAQETDVTDVTFTIGGQVFQAKGRVSVVTGWKALFADEKQAQEQEDNTALPALKKEEISPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRESAGLGTEATRAGIIEALFKRRLLARKKKNLHATQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRRGNSPD
(50) DNA topoisomerase [Xenorhabdus nematophila ATCC 19061]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSIIVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPAQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILPGEKTESLWQAGLGRARADWLMGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVVATLQKDGIGFRVKWLPAPDDCDEEKRCIKEDIAHSVVQCCQEAQNAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDASTLSRVWNDSQITAHHAIIPTRHPFDMTKLTADELKVYQLIRQYYLAQFLPAQETDVTDVTFTIGGQVFQATGRVSVVTGWKALFADEKQAQDQDGNTALPVLKKAETCPVIRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEALFKRRLLARKKKNLHATQLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRTTLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVIGSRKTRRGNSPD
(1671) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAAETGRQTE
(284) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1883) DNA topoisomerase 3 [Salmonella bongori NCTC 12419]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWSLADLPIVPEKWQLQPRPSVTKQLNVIKRFLQDAGEIVHAGDPDREGQLLVDEVLDYLQLPAEKRQRVQRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMKAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYALIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPIVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVRQFRGIIAPVGEGKKKSAPRKRPAKKSPPQA
(844) DNA topoisomerase 1 [Salmonella bongori NCTC 12419]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGDALPLQVTHQNDKPFRPVSREQTLAAISLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVSVMAESLKDMEADAQKLYQLIWRQFVACQMTSAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKSDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVIRFSRKTKQQYVAAEKEGKATGWSAFFVDGKWVEGKK
(743) DNA topoisomerase [Serratia plymuthica AS9]
4
MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPWRESVLPIVPTQWKMAIKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHFTGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAREQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRGTLQKGGIAFPANWVPAANYCDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMSANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRAFVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEATFNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELKTLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYLEKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGHLVEKGKTQAVKFTAPPSPPCPTCSGSMRRRAGKKGGGAFWGCSNYPTCQGVINIDAKGGRKAKRYKAKSPTKNKATGSE
(369) DNA topoisomerase 3 [Serratia plymuthica AS9]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGNNDVVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNAIKKLLHDADEVVHAGDPDREGQLLVDEVLDYLALTPEKRHSVRRCLINDLNPQAVERAIDRLRDNRDFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVPKDFFEVKAHIVTPKEERFVALWQPSDSCEPYQDEEGRLLHRPLAEHVLKRIEGQPALVTSYNDKRESDTAPLPFSLSTLQIEASKRFNLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISAHQPDLYPQPVIDSDRRNRCWDDKKVDAHHAIIPTARASKVSLSQDELNVYGLVARQYLMQFCPDAMFRKCVIELDIAGGKFVAKARFLAEAGWRTLLGSKERDEENEGSPLPVVAKDDELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIELLFKRAFLYKKGRYIHSSETGRALIHSLPDIAARPDMTANWEATLTQISEKSCRYQDFMQPLVGTLQELIYQAKQSRASMAFRGLPPSPSAGAKKRKKSAGKAREKSE
(1540) DNA topoisomerase 1 [Serratia plymuthica AS9]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTEDKAKKKVKKDEKTALVNRMGVDPYHGWKADYEILPGKEKVVAELKSLAENADHIYLATDLDREGEAIAWHLREVIGGDEKRFSRVVFNEITKNAIQQAFKQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKNDTALQMEVTHAHDKPFKPVNREQTHAALKLLEKARYTVLDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGDNFGDKYLPKAPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLSVKAGDYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPYVEVGSDLELQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEENFRELMNYDFTARMEDGLDQVANNHAEWKAVLDEFFAEFSEQLETAEKDPEDGGMRPNQMVMTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPETEVLNILEGDDAETNALRARHRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEEGEFRLKGYDGPVVECDKCGSEMHLKMGRFGKYMGCTNETCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADGEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(1816) DNA topoisomerase 3 [Shigella boydii Sb227]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTRQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA
(1810) DNA topoisomerase 1 [Shigella boydii Sb227]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(310) DNA topoisomerase 3 [Shigella flexneri 5 str. 8401]
10
MANWCQRAAVVPWLRSVNLMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIA
(1024) DNA topoisomerase 1 [Shigella flexneri 5 str. 8401]
9
MRRIPGRIKLGKVNMGKALVIVESPAKAKTINKYLGCDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(366) DNA topoisomerase 3 [Yersinia enterocolitica subsp. enterocolitica 8081]
10
MMRLFIAEKPSLARAIADILPKPHRRGDGFIACGSDNMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWRLQPRPSVSKQLNVIKQLLQQADEVIHAGDPDREGQLLVDEVLDYLDLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIEDFVAKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRIAGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISMHQADLLPLDVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDESKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVEKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVATLQDLISQAKQNRSPQVFRGLPAAPSGAIKKRKKTSSKTKENKS
(1742) DNA topoisomerase 1 [Yersinia enterocolitica subsp. enterocolitica 8081]
9
MGKALVIVESPAKAKTINKYLGNNYVVKSSVGHIRDLPTSGSASKKSANSTEDKAKKADKPKTKVKKDEKVALVNRMGVDPYHGWKAQYEILPGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKGEVPIQMEVTHAHNKPFKPVNREQTHAALKLLENARYKVLDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPSAPNQYSSKENSQEAHEAIRPSDVNVMAEQLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSELDLQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESGLDQVANDQAEWKAVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVMTSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEAEILNILEGDDAETNALRAKRRCQKCGTAMDSYLIDNQRKLHVCGNNPTCDGYEIEEGEFRIKGYEGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVTDNEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEAKK
(323) DNA topoisomerase 3 [Yersinia pestis A1122]
10
MRLFIAEKPSLARAIADILPKPHRRGDGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPVGPSGAPKKRKKISSKAKESKS
(1303) DNA topoisomerase 1 [Yersinia pestis A1122]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSANSAEEKAKKDDKPKKKVKKDEKVALVNRMGVDPYHGWKAQYEILSGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNISRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLVAKGDIPIQMEVTHAHGKPFKPVNREQTHAALTLLENARYKVLDREDKPTSSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPATPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQRLYQLIWRQFVACQMPPAKYDSTTLTVQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSDLDLQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESGLDQVANDQAEWKAVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVMTSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPDAEILNILEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEAGEFRIKGYEGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLLELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVVDKEGNKTLVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEAKK
(1001) DNA topoisomerase 3 [Yersinia pestis]
10
MMRLFIAEKPSLARAIADILPKPHRRGDGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTACASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPVGPSGAPKKRKKISSKAKESKS
(1798) DNA topoisomerase 3 [Yersinia pestis]
10
MRLFIAEKPSLARAIADILPKPHRRGDGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPVGPSGAPKKRKKISSKAKESKS
(490) DNA topoisomerase 3 [Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGDNQFVTWCIGHLLEQAEPDAYDSRFARWSLVDLPIVPEKWQLKPRPSVAKQLDIIQELLKKADEVVHAGDPDREGQLLVDEVLDFLNLDGEKRKNVRRCLINDLNPQAVAKAVDRLRDNRDFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYRGVLSVGRVQTPVLGLVVRRDEEIEHFVPKDFFEVKAHIVTPKDERFTAIWQPSESCIDFQDEEGRLIHRPLAEHVVARITGQPAYVTSYQDKRESEVAPLPFSLSSLQIEAAKRFGLNAQQILDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISVHTINLLPQDLLEVDRKNRCWDDKKVDAHHAIIPTARNSHINLTDNEANIYGLIARQYLMQFFPDAIFRKCVIELEIAGGKFIAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKGDELLCERGEVVDRQTQPPKPFTDATILSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKREFLYKKGRYIHATPAGRALIHVLPDIAALPDMTAHWESRLTQISEKQFRYQDFMKPLEETLQQLIWQAKQSRNLQAFRDLPPVPVKGKNGKKSKSGKNTKATAP
(1696) DNA topoisomerase 1 [Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSASQKSSSSSTDKSKKKVKKDEKAALVSRMGVDPYRGWEANYQILPGKEKVVAELKSLAEKADHVYLATDLDREGEAIAWHLREVIGGDSDRFSRVVFNEITKNAIKQAFDKPGELNIDRINAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWQLHADLLAKGEISLHMEVTHKRGKPFKPVNSEQTQAAVSLLEKARYKVVDREDRPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALDMVRGYISDNFGDKYLPKTANTYSSKENSQEAHEAIRPSSVDVMAEQLKDMDADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFELRAKGRTLRFDGWTKVMPALRKGDEDHTLPVVEVGTELDLQQLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYSEKMGEIVTDRLEENFNELMSYDFTARMEDQLDQVASNKAEWKGVLDEFFTDFSEQLEVANKDPEDGGMRPNPMVITSIACPTCDRPMGIRTATTGVFLGCSGYALSPKERCKQTINLIPENEILNILEGDEAETNALRARRRCKKCGTAMDSYLIDNQRKLHVCGNNPACDSYEVEEGEFRIKGYDGPVIECDKCSSEMHLKMGRFGKYMGCTNETCKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADAEGNKTVIRFSRKTKQQYAASEKNGKATGWSVFYVDGKWIEKDKK
(147) DNA topoisomerase 3 [Citrobacter rodentium ICC168]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLSDLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEVVHAGDPDREGQLLVDEVLDYLQLAAEKRQQVQRCLINDLNPQAVERAIERLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFIPKDFFEVRAHIVTPADERFIAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPAFVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAIGVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSTINLSENEAKVYNLIARQYLMQFCPDAVFRKCVIELEIAKGKFIAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKSTPVRRFRGIVAPGGGSSEKKKSAPRKRAAKKSPPSAEAGL
(1777) DNA topoisomerase 1 [Citrobacter rodentium ICC168]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGDALPLQVTHQNDKPFRPVNREQTQAAVSLLEKARYTVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDSFGKKYLPDSPNQYASKENSQEAHEAIRPSDVTVLAETLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLVELIPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHEAEWKAVLDNFFSDFTQQLDKAEQDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVAAEKDGKATGWSAFYVDGKWVEGKK
(814) DNA topoisomerase 1 [Buchnera aphidicola str. Ua (Uroleucon ambrosiae)]
1
MSKSLVIVESPAKAKTINKYLGNEYIVKSSIGHVRDLITRKFKKPTHKSQKYSQSYSLNNKQKTYFIENIGIDPYKDWKAEYSILPGKEKIISELKNIAHKVDHIYLATDLDREGEAIAWHLKEVIGGDSTKFSRVVFNEITKHAIKKAFKNITKINMHRVHAQQARRFMDRIVGYMISPLLWEKISRGLSAGRVQSVAVRIIAEREDIIKKFIPEEYWKLNVSFVLKNQNKIIMDVTHFNNKKFRPNNQNELNIAIEEIKKSSFFIKKFEKKIIYKQAPAPFITATLQQSASLILGFSVKKTMFLAQKLYEEGYITYIRTDSCYLSLNAINKVRKYIKKFYGDAYLSNKYYIHTNKKHSQEAHEAIRPSDIKVKNINTNTINLDAEKLYLLIWNQFIASQMKPAQYQFITIKIFSHLFQLQKQLKIVLFDGWTKMFKEKNENITQIPIIDIGSILNIDNIIINQKFTKPLPRFTEASLVRELEKKGIGRPSTYSVITSKIQERGYVTIKKNKFYAEKMGSILTIRLKKSFSNLIDYNFTANMEKKLDQIAENKLSWINVLNSFFKDFSEKLDQAKKNPEEGGMELNNIVFTSIKCPTCFKKMGIKNAITGVFLSCLGYQDNLKKRCKQTINLIPLNDVLKKKQNNEVTSGFTKLINKCEKCNMFMDSYFINKNIQLHICINNPSCIGYKVEKGNFKIPIWLSKTVECDKCYSNMLLKKGPFGKFFICVNIKCKNTRKILPNGEISDPKLEPIPFPELLCKKSNASFVLREGVSGIFFAASTFPKSRETRSPFIEELAKFQYLLPKKIYYLSKAPIVDDKGNKTIVCFNRKNKEYYVTSKKKGKFTGWSAVFIKNKWCVINQ
(198) DNA topoisomerase 1 [Candidatus Vesicomyosocius okutanii HA]
1
MAKNLVIVESPTKAKTIEKFLGKDFSVKSSIGHIRDMPKKNMGIDIDNNFTPTYEITADKKKVVTDLRKAVKVAEKVYLATDEDREGEAIAWHLLEALNLPKDTPRIVFHEITKNAITHAISEPRIVNYRLVDAQQARRIIDRLVGFEISPILWRKISGARSAGRVQSPVVRLVVEREREISKHIDNSTYKVKAELSSESGEIFKVKLSKEFKSKKQVLAFANILLLANLTITSIEKKPFKRSPKPPFITSTLQQEAFQKLGFSVKQTMILAQNLYRKGFITYMRTDSFILSETAIEAVHKIIVREFGSEYHNTRRYKSKESRAQEAHEAIRPTDLTRSNIFDIEEQAAKLYILIYKRTLSCQMSDAQLQKTKIKINIEGLDEIFIANGEVLVFPGFLRIYDYLLSEDKLLPRLNKGNALNLVNFKARESFSRAKPRYTEASLVKKIEEMGIGRPSTYSTMVSTVQDRNYVTKKNGRGVEREYQLIEIKDNQVIQSQPSEVISGEKNKLFPTNIAYLLTDFLVKYFNNIIDYKFTAKLESDFDTIATQNISWQGVVKNFYIPFHQKIEDAVNISREEIHSMRNLGVDPKSDKPVSVRVGRYGAFVQIGHTDDKDKPTFASFRGLLDIESITLDEALELFNMPRHLGETDNFGTIKANYGRFGPYIQYGKKYVSLKEDIPEEVSLEKALELIKIKEKFDSERIIKIFDGSDIQLLNGRFGPYIWNGKKKGKGQKNITIKKVFGDKPIANLTLEECKKAISGKLKLKKKIVKKEVTKNS
(1021) DNA topoisomerase 3 [Rahnella sp. Y9602]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGNDQVVTWCVGHLLEQAQPDAYDSRFARWSLADLPIIPEKWQLQPRSSVAKQLNVIKRLLLEASQVVHAGDPDREGQLLVDEVLDYLELTPEKRHATQRCLINDLNPQAVERAIERLRDNRDFIPLCVSALARARADWLYGINMTRAYTILGRNAGYNGVLSVGRVQTPVLGLVVRRDEDIENFVPKDFFEVKAHIVTPAEERFVALWQPSDSCEPYQDEEGRLLHRPLADHVVARIAGQPAMVTGYNDKRENDIAPLPFSLSTLQIEGSKAFGLSAQQILDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAIGVHRPDLMPQPAVDTDLRNRCWDDKKVDAHHAIIPTARSSNVNLTDDERKIYGLVARQYLMQFCPDAVYRKCVIDLDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGTPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFRREFLYKKGRYIHSSDTGRALIHSLPDIAARPDMTADWESTLTRISEKSCRYQDFMQPLVATLQNLIMQAKTNRVSSAFRSLPSKPAGAVAKGKSAPKRRKASTKGKEANSDE
(936) DNA topoisomerase 1 [Rahnella sp. Y9602]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKTADSTEEKTKKKVKKDEKTALVNRMGVDPYHGWEAQYEILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQNAFKEPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLLAKKETALQMEVTHHLEKPFKPVNKEQTHAAVSLLEKARYTVVDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVEMVRGYIGENFGDKYLPKAPLQYSNKENSQEAHEAIRPSDVAVISEQLKDMEADAQRLYQLIWRQFVACQMTPAQYDSTTLTVKAGDYSLRAKGRTLRFDGWTKVMPALRKGDEDRTLPAIEVGTDLELQQLLPTQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVHVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMEDGLDQVANNKAEWKAVLDEFFTEFSKQLETAEKDPEEGGMRPNQMVLTSIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLIADAEVLNILEGDEAEANALRAKRRCVKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELKRFKDRLPEKLSYLADAPVADPEGNKSMVRFSRKTKQQYVSSEKDGKATGWTAFFVDGKWVEGKK
(418) DNA topoisomerase 3 [Rahnella aquatilis CIP 78.65 = ATCC 33071]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGNDQVVTWCVGHLLEQAQPDAYDSRFARWSLADLPIIPEKWQLQPRSSVAKQLNVIKRLLLEASQVVHAGDPDREGQLLVDEVLDYLELTPEKRQATQRCLINDLNPQAVERAIERLRDNRDFIPLCVSALARARADWLYGINMTRAYTILGRNAGYNGVLSVGRVQTPVLGLVVRRDEDIENFVPKDFFEVKAHIVTPAEERFVALWQPSDSCEPYQDEEGRLLHRPLADHVVARIAGQPAMVTGYNDKRENDIAPLPFSLSTLQIEGSKAFGLSAQQILDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAIGVHRPDLMPQPAVDTDLRNRCWDDKKVDAHHAIIPTARSSNVNLSDDERKIYGLVARQYLMQFCPDAVYRKCVIDLDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGTPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFRREFLYKKGRYIHSSDTGRALIHSLPDIAARPDMTADWESTLTRISEKSCRYQDFMQPLVATLQNLIMQAKTNRVSSAFRSLPSKPAAAKGKSAPKRRKASTKGKEANSDE
(1587) DNA topoisomerase 1 [Rahnella aquatilis CIP 78.65 = ATCC 33071]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKTADSTEEKTKKKVKKDEKTALVNRMGVDPYHGWAAQYEILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQNAFKEPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLLAKKETALQMEVTHHLEKPFKPVNKEQTHAAVSLLEKARYTVVDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVEMVRGYIGENFGDKYLPKAPLQYSNKENSQEAHEAIRPSDVAVTSEQLKDMEADAQRLYQLIWRQFVACQMTPAQYDSTTLTVKAGDYSLRAKGRTLRFDGWTKVMPALRKGDEDRTLPAIEVGTDLELQQLLPTQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVHVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMEDGLDQVANNKAEWKAVLDEFFTEFSKQLETAEKDPEEGGMRPNQMVLTSIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLIADAEVLNILEGDEAETNALRAKRRCVKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELKRFKDRLPEKLSYLADAPVADPEGNKSMVRFSRKTKQQYVSSEKDGKATGWTAFFVDGKWVEGKK
(1002) DNA topoisomerase [Halothiobacillus neapolitanus c2]
4
MRVYLCEKPSQARDIAAVLGIQSKDKSSITTADGVVTWAFGHLLEQAPPDAYDDSLKRWALASLPIAPTQWKVEVKSSAKDQFKAIATLLKRATEVVIATDADREGEMIARELMAFVGFKGKVQRLWLSALDAASVKKALAALKPSAETAGLYQSALGRSRADWLVGMNLTRAFTLAGCSQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFFEAGQSFSTKWKVPEGAGDDAGRCVDQSIVDAVASKITGKTGTVSQYETKRISENPPLPFSLSTLQKTCSAKFGLGAQEVLDIAQALYETHKATTYPRSDCNFLPEEQFQEASSIVTALAKSDTEVQGIVDLLDFSRKSPAWNTKKITAHHAIIPTQTPPNMDAMSDNERRVYELIRRQYLAQFLPNYEYDRTQIGISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLPALTQGQTLPLSHTEIAAKQTKPPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTEATRAGIIANLIERGFITKKGKQVISSDVGRQLIDALPDSVKSPALTALWEQSLEEIAEGKRELAGFEADVVKFITAIIDQIKKQHADAPAPTRPTADCPTCKAQGQAEKVYSIKKQCHYWHCKACNQWFDDAAGKPVPKAAASSSKTKPAPRKKTTARKAK
(1231) DNA topoisomerase 1 [Halothiobacillus neapolitanus c2]
1
MSQTLVIVESPAKAKTIKKYLGPGYEVLASYGHVRDLIPKDGAVDTAHDFAMNYTLIDKNVRHVDAIKKALKSSDILLLATDPDREGEAISWHLRELLAEAGLLKNKTAQRVVFYEITKKAVQEAVAHPRDLSIDLINAQQARRALDYLVGFNLSPLLWKKINPGLSAGRVQSPALRLIVEREAEIEAFNPQEYWTILADCQADRAAEKSRFNARLLTLDGQKAEQFTLTNETDAQSARSRILEAAAGTLTVRSVEKRERKRNPAPPFTTSTLQQEGVRKLGLSASRVMRLAQELYEGVDIGAGTVGLITYMRTDAVTLSEDALTQIRAHIGDKYGAAYLPASPNRYKTKSKNAQEAHEAIRPTSAAHTPDSVRAFLNKDQFRLYEMIFKRAVASQMTPAVYDQVSVDLAVNDQHSFRANGSTLKFPGFIALYREDEDDASGDNDEDRRLPPLTVGDKIALNDIAADQHFTEPPPRFTEASLVKTLEEYGIGRPSTYASIISTLQAREYVLLDQRRFKPTDMGRVVNGFLTDYFRDIVDYEFTAKLEDDLDAVSRGERDWVPLMREFWTPFHDRVEHTNENVTRQEAAQGRELGIDPKSGKPVSVRLGRFGPFAQIGTKDDEEKPKFASLKRSQSIATITLDEALDLFQLPRKLGETPEGEPVEVAIGRFGPFVKFGKMYASLGKDDDPYTIELPRALEIIEIKKLAEKNRYITQFDNGVSVQNGRYGPYITDGKKNAKIPKDKDPKSLTLEECVALLAAAPEKKSARGKTAAKATAKKTAAPKATAPKTTAKKSTTPRAKKASATDAQAPAKKTPVKKPATARSKKPAATIPE
(1337) DNA topoisomerase 3 [Pantoea ananatis PA13]
10
MRLFIAEKPSLGRAIADVLPKPHRRGEGFIACGNDQIVTWCVGHLLEQAQPDVYDSRYARWSLVDLPIIPEKWRLQPRPSVAKQLKVVEGLLAQADEVVHAGDPDREGQLLVDEVLDYLQLPAEKRSKVQRCLINDLNPQAVERAINRLRENREFIPLCVSALARARADWLYGINMTRAWTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIANFVPKDYFEVKAHIVTPDESRFTANWIPSEACEPWQDEEGRLLKRSLAEHVVARISGQPAIVTAYSDKRENDIAPLPFSLSSLQIEAAKRFGLSAQAVLDICQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAIQSHQPDLTPPADFDADRKNRCWDDKKVDAHHAIIPTARASAVKLNENEQQIYGLVARQYLMQFCPDAVFRKCTIDLDIAGGKFVAKARFLAEAGWRALLGGKERDEENDGMPLPVVAKDDELLCERGEVLAKQTQPPRHFTDATLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFRRSFLHKKGRYIHSTDAGKALIHSLPDLAARPDMTAQWESTLTRISEKACRYDEFMQPLVQTLSGLIQQARQQPSGQAFRGLPSTGQKRPPRKAGRKTKETE
(130) DNA topoisomerase 1 [Pantoea ananatis PA13]
9
MGKALVIVESPAKAKTINKYLGSGYVVKSSVGHIRDLPTSGSTAKKSAETSTDKKVKKVKKDEKAALVSRMGVDPYHGWEADYQILPNKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIRQAFDTPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELSANLTTPKGDDLAMDVTHAGDKPFRPVNHEQTHAALALLEKARFAVTDREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVSMVRGYIEGNFGKKYLPDNANTFASKENSQEAHEAIRPSDVDVVAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVTAGDYKLKAKGRTLRFDGWTKVMPALRKNDEDRTLPPVNVGDELSLQALLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYAAIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMESSLDQVANNQAEWKAVLDRFFSDFSQQLEQAEKDPEEGGMQPNQMVLTTIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCQKCGTAMDSYLIDNGRKLHVCGNNPECDGYEIEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFHDRLPEKLKYLAEAPATDPEGNKTLVRFSRKTKQQYVASEKEGKATGWSAFYIDGKWQEAKK
(1818) DNA topoisomerase [Pantoea ananatis PA13]
4
MRLFLCEKPSQGRDLAAVLGASRRGEGFMTGNGVTVTWAVGHLLETAPPEVYGQQYGKPWSLSALPILPSRWQVVVKKDTQDQFKVIEKLLRQADEVVIATDADREGEVIARELLDYCGWDGRILRLWFSALDELSVRAALSDLRPGQASVGMYHAGLGRSRADWLIGMNLSRLYTLRAAEAGFEGVVSVGRVQTPTLALVARRDREIAAFVPKPYWQVKATLSASGVSFQASWVPAAVYADEEKRCIHQNIAQQVAQLCRQAGVSTVTEYETKREKEAAPLAFSLGTLQRACGKMWNMSPQKVLDTAQSLYETHKATTYPRTDCGWLPKSMREEIPAVFDAMARTDPSPEFASLLSQLDRGFASRIWNDKKITAHHGIIPTRNAVQLSSLTETERQVYLLIRRNYLAQFLPLCESDATRISFDIGGQLFRTTGRTEVLKGWKVLFTKDEEDKDTAEEDIAGSLPPLSKGAQCGVTDAEVKQLMTQPPAHYTFDTLIGAMMNAAAYVTDLQLRKILKENAGLGTEATRAGIIEQLLSRRFITLKGSKLLATDLGADVIDALPPQLTDPGMTALWEQALDEVAAGRMNLNDFLQRQTAWTSTLVSQGMQQRISIRVPPSPPCPLCGSKTALRRSPKGEFRSCTRYPECKGIISLDSGRRKSPARAKSPKTKKN
(536) DNA topoisomerase 3 [Pantoea sp. At-9b]
10
MRLFIAEKPSLGRAIADVLPKPHRRGEGYIACGNDQVVTWCVGHLLEQAQPDSYDSRYARWNLADLPIIPEKWQLQPRPSVAKQLKVIEGLLAQATEVVHAGDPDREGQLLVDEVIDYLQLPAEKRQKVQRCLINDLNPQAVERAVSRLRENREFIPLCVSALARARADWLYGINMTRAWTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFIPKDYFEVKAHIVTPKDERFVASWVPSDACEPWQDEEGRLLHRPLADHVLERINGQPARVTAYNDKRESEIAPLPFSLSSLQIEAAKRFGLSAQNVLDCCQRLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIQAHQPDMTPPADFNPEQRNRCWDDKKVDAHHAIIPTARASKVNLSENEANIYGLIARQYLMQFCPDAVFRKCVIDLDIAGGKFVAKARFLAEAGWRALLGSKERDEENDGTPLPVVSKGDELLCERGEVLAKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFRRTFLVKQGRYIHSTQAGRALIHALPEMAARPDMTAHWESTLTRISEKACRYDEFMQPLVSTLIGLIGQARQQPSLQAFRGIAASGSASEKKRTRKPARRKMKETE
(702) DNA topoisomerase 1 [Pantoea sp. At-9b]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTARKSADGEKTKPAGKKVKKDEKAALVNRMGVDPWHGWQADYQILPGKEKVVSELKSLAADADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIRQAFEKPGELNIERVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDADLVTPKGDALAMQVTHQGDKAFRPVNREQTYAAVALLQKARYDVLDREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAIAMARSYIDKNFGANYLPAAPNTYASKDNSQEAHEAIRPSDVAVAAEKLKDMEADAQKLYQLIWRQFVACQMVPAQYDSTTLTVGAGDFKLKAKGRTLRFDGWTRVMPALRKNDEDLTLPPVNVGDVLDLKEVLPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDSLDQVANNQAEWKGVLDSFFSDFSQQLDQAEKEPEEGGMQPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNVLEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPECDGYEIEQGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFADRLPEKLKYLAEAPAADPEGNKTMVRFSRKTKQQYVASEKEGKATGWSAFYVDGSWQEAKK
(535) DNA topoisomerase 1 [Alkalilimnicola ehrlichii MLHE-1]
1
MSKNLVIVESPAKAKTINKYLGKDYKVLASYGHVRDLVPKEGAVDPEHGFAMKYTTIDKNAKHVDTIAKAMKQADALYLATDPDREGEAISWHLYELLKEKGALKDKPVYRVVFHEITPRAIREAMEHPRELSTPLINAQQARRALDYLVGFNLSPLLWKKIATGLSAGRVQSPALRMIVEREEEIEKFISREYWTVEADLARNGEAFPGRLHTLDGQRVKQFDIDNGERAREVEHQLARAAGMALSKSHIDAGEGESPVQSPGTVQVTQVEKKQRRRNPAAPFTTSTLQQEAARKLGFTANRTMRVAQQLYEGIDIGGGVTGLITYMRTDSVNLSQEAVADLRDTIAKRYGEDRLPKAPQVYRTKSKNAQEAHEAIRPTGAFRLPEEVRGKLSDDQFRLYELIWKRAVACQMIPALINTVAVDLACGEGNSFRATGSTIAEPGFMAVYLEGTDDRKPDVGSSERILPPLKEGDKVALERIKPEQHFTEPPPRYTEASLVRALEEYGIGRPSTYAAIISTLQQRKYVELDGKRFRPTDIGRVVNRFLTDHFDRYVDYDFTARLEDDLDAVSRGERDWVPLLEEFWQPFKDKVDEKATISREEVMQSRDLGTDPKTGKPVSVRVGRFGPFVQLGTKDDEEKPRFAGLRPGQSMDKITLEEALELFKLPRDMGETPEGEPMQVNIGRFGPYVRFGNKFVSIKDDDPYTISRERCLELVEEKKRIERERTIRDFEGSDIRILKGRYGPYITNGKKNARIPKDREPESLGLEECEELIAKAPERKGRRRTGGTGRKRSTKA
(715) DNA topoisomerase 3 [Pantoea vagans C9-1]
10
MRLFIAEKPSLGRAIADVLPKPHRRGDGFIACGNDQIVTWCVGHLLEQAQPDSYDSRYARWSLNDLPIIPEKWQLKPRPSVAKQLKVVEGLLAQASEVVHAGDPDREGQLLVDEVLDYLNLPPEKRSKVQRCLINDLNPQAVDRAVNRLRENREFIPLCVSALARARADWLYGINMTRAWTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFEVKAHILTPDGARFVASWIPSEACEPWQDEEGRLLKRALADHVVARITGQPAIVTAYSDKRENDVAPLPFSLSSLQIEAAKRYGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPEEHFAGRRTVLKAIQAHQPQLTPPADFNADRRNRCWDDKKVDAHHAIIPTARSSAVKLSENEQHIYELVARQYLMQFCPDAVFRKCVIDLDIAGGKFMAKARFLAEAGWRALLGSKERDEENDGMPLPVVAKGDELLCERGEVLAKQTQPPRPFTDATILSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFRRGFLVKKGRYINSTDAGRALIHSLPDLAARPDMTAQWESTLTRISEKACRYDEFMQPLVQTLTGLIQQARQQPAAHAFRGLPSTGQKRPVRKTRRKVKETE
(582) DNA topoisomerase 1 [Pantoea vagans C9-1]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSTAKKSADASTDKKVKDASTDKKVKKVKKDEKAALVSRMGVDPYHGWEADYQILPGKEKVVAELKALAANADHIYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVNAALTTPKGDELSMDVTHKGDKAFRPVNRDETYAAVALLEKARYEIVDREDKPTSSKPGAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVAMARGYIESNFGKKYLPETAITYASKENSQEAHEAIRPSDVEVVAEKLKDMEADAQKLYQLIWRQFVACQMTPAKYDSSTITAAAGEFKLKAKGRILRFDGWTKVMPALRKNDEDRTLPAVSVGDVLDLQQLLPGQHFTKPPARFSEASLVRELEKRGIGRPSTYAAITSTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESNLDQVANNEAQWKAVLDHFFADFTQQLELAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCQKCGTAMDSYLIDNERKLHVCGNNPECDGYEIEKGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRSGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFKDRLPEKLKYLADAPAADPEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWQEAKK
(885) DNA topoisomerase 1 [Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum)]
9
MGKSLVIVESPAKAKTINKYLGSHYVVKSSVGHIRDLPKSGSNNKKNASEIIKKQKTEKKMFQDHQSSLIKRMGIDPYHGWKAQYEILSGKEKVVSELKALAAKADHIYLATDLDREGEAIAWHLREVIGGDPQRFSRVIFNEITQNAIQQAFKKPGELNMNRIHAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPQEYWHLEANLLTPQKIMIPMMVSHFEGEPFKPLNREQTYAAVNDLEDAQYVVLDRKDKPTSSKAGAPFITSTLQQAASTRLGFGVKKTMLMAQRLYEAGHITYMRTDSTHLSQDALSMVRNYIQKHFGNRYLISPAYEYGNKKNAQEAHEAIRPSNVDVFSEQLEDMEPDARKLYQLIWRQFVACQMTPAQYDVTTLIVEAKNYQLRAKGRTLRFDGWTKVMPALRKGDEEETLPIIAVGTSMHLEKLIPSQHFTKPPGRYSEASLVKELEKRSIGRPSTYATIISTVQERGYVRIENRRFYAEKMGEIVTNRLEENFRELMNYDFTARMENALDQIAQHQAEWKKVLDEFFSEFSEQLNIAEKDPSEGGMRPNSMVIMDINCPACGQKMGIRTASTGVFLGCSSYALPPKERCKTTLNLISENEILNLLDGDEAETNALRSRRRCEKCETAMDSYLLDTARKLHICGNNPICDGYQMEQGEFRIKGYEGPIVECDKCAHEMHLKVGRFGKYMGCTNEECKNTRKILRNGEVAPPKENPVPLPELLCEKSDAYFVLRDGAAGLFLAANTFPRSRETRAPRVEELQRFKDRLPEKWHYLVEAPLKDTEGNKTFLRFSRKTKEQYISSEKSGKATGWCAFYIDGQWVEGKKRPLVKS
(1163) DNA topoisomerase 3 [Escherichia fergusonii ATCC 35469]
10
MPWLRFVKSMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDTYDSRYARWNLTDLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNNKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRCIVAPDGGEGNKKTSSRKRAAKKSPPADEAGSGAIA
(1194) DNA topoisomerase 1 [Escherichia fergusonii ATCC 35469]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANTTTPSGDALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPAGNKSMVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEGKK
(824) DNA topoisomerase 3 [Escherichia coli NA114]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETYKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTSVRQFRGIMAPGGGEGKKKDSPRKRAPKKSPPSEEAGNGVII
(307) DNA topoisomerase 1 [Escherichia coli NA114]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSTAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(1300) DNA topoisomerase 3 [Cronobacter turicensis z3032]
10
MRLFIAEKPSLGRAIADVLPKPHRRGDGFIECGNGQVVTWCVGHLLEQAQPDAYDSRYGRWNLADLPIVPEKWQLQPKPSVAKQLNVIKKLLREAQEIVHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDKLRENREFVPLSTSALARARADWLYGINMTRAYTLLGQNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFVAKDFFEVKAHIVTPAQERFTALWQPSEACEPYQDEEGRLLNRALAEHVVKRIEGQPARVTSYNDKREGEAAPLPFSLSTLQIEASKRFNLSAQAVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLKAIGVHASDLLPQPAVDPERRNRCWDDKKVDAHHAIIPTARSAPASLSDGEAKIYGLIARQYLMQFCQDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGAKERDEENDGTPLPVVAKGDELHCERGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLEKQGRYIHSTPAGKALIHALPELAARPDMTAQWESTLTQISEKQCRYQDFMQPLVHTLYTLIDQARSAPVRQFRGLVAPQQAQKRRAGKGGKKPAARKRSGAQPATE
(1760) DNA topoisomerase 1 [Cronobacter turicensis z3032]
9
MGKALVIVESPAKAKTINKYLGKDFVVKSSVGHIRDLPTSGSAPKKSAESAPTKPAKKVKKDERGALVNRMGVDPWHNWEAQYEVLPGKEKVVSELKSLAEKADHIYLATDLDREGEAIAWHLREVIGGDETRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDALLSTPKSDQLSVQVTHHKDKPFRPVNRQDTEAAVALLKAASYQIVEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVSMVRNYIGEEFGKKYLPENPNQYASKENSQEAHEAIRPSDVSVLAESLKDMENDAQKLYQLIWRQFVACQMTPAQYDSTTLTVAAGDFRLKARGRILRFDGWTRVMPALRKGDEDRTLPAVNQGDKLSLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFPELMNFDFTAQMEDSLDQVANHEAEWRGVLDTFFDDFSRQLDTAEKDPEEGGMRPNQMVLTSIDCPTCGRPMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEVEEGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFRDRLPEKLLYLADAPAQDPEGNPAVVRFSRKTKQQYVASEKDGKATGWSAFYVDGKWAEGKK
(1411) DNA topoisomerase 1 [Candidatus Moranella endobia PCIT]
9
MGTALVIVESPAKAKTINKYLGKGYVVKSSVGHIRDLPKKSPASKNKNNTCIPDQHTVLIKRMGIDPFHSWKARYEILPGKEKLVTELRALAEEADHVYLATDLDREGEAIAWHLREAIGGDEKRFRRVVFNEITRNAVTQAFENPVVLNMNRVNAQQARRFMDRIVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKSFMPAEYWELHVALQTSQAAQLMMKVTHQQEKPFKPAKQQQLQAAISILEHTDYIVSNRDDKITTSKPGSPFTTSTLQQAASLHLGYRVKKTMLLAQRLYEAGHITYMRTDSTHLSRNALNMARCYISAAFGHSYLPTQPKEYVSKNNSQEAHEAIRPSDVSALAEQLNNMEAEAQKLYQLIWRQFVACQMKPAQYNYTILTVNAGEFQLSAHGRQLMFDGWTKVMPTQHTEKDKRTLPTVKEGNNLTLNKILPSQHFTKPPARYSEASLVKELEKRGIGRPSTYVSIISTIQERGYVHADNRRFYAEKIGEIVTDRLEENFSELMSYDFTAKMEATLDQVATNQQDWKSVLDAFFSKFSQQLKNAEQNPVDGGMRLNQMIMTSINCLVCDRPMGIRTASTGVFLGCSGYQLPPKDRCKNTIHLIPESETLNRFTVGDEETNALRARRRCVKCRTAMDNYVIDSKRKIHVCGKNPLCDGYNIEQGEFIVVAYNGRVVECEKCGFNMQLKFGRFGKYIACTNNNCKNTRKILRNGDVAPPKEDPVLLPELPCYGHSDAYFVLREGAVGVFLAANTFPKYRETRKPLVAELARFRERLPVKLQYLADAPIEDDEGNSTLVRFSRKTKQQYISSEKDGKATGWTAFYVNGKWQVNRKSSGCGP
(462) DNA topoisomerase 3 [Enterobacter cloacae EcWSU1]
10
MRSVNSMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDVYDSRYARWNLNDLPIVPEKWRLQPRPSVTKQLNVIKRFLHDATEVIHAGDPDREGQLLVDEVLDYLELAPEKRQQVQRCLINDLNPQAVERAISRLRANSEFIPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPKDERFTAVWQPSDACESYQDEEGRLLHRPLAEHVVNRITGQPAIVTSYNDKRESEPAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHSVMNAIAVHAPDLLPQPVVNPDIHNRCWDDKKVDAHHAIIPTARASNVNLTENEAKVYNLVARQYLMQFCPDAVFRKCVIELEIAKGKFIAKARFLAEAGWRTLLGNKERDEENDGTPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLEKKGRYIHSTEPGRALIHSLPELAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYELINQARNTPVKQFRGMVAPGGAPKKPFKKKKSAA
(542) DNA topoisomerase 1 [Enterobacter cloacae EcWSU1]
9
MNMGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERSALVNRMGVNPWHNWDAQYEVLPGKEKVVNELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDANVTTPGGDALPLQVSHQNDKPFRPENRDQTMAAVALLEKARYQVLEREDKPTSSKPGAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPESANQYASKENSQEAHEAIRPSDVSVLAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDELSLVDLVPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEANFRELMNYDFTAQMEDSLDQVASHQAEWKKVLDSFFSDFTNQLEKAEKDPEEGGMLPNQMVLTSIDCPTCGRKMGIRTATTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELHRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKEGKATGWSAFFVDGKWVEGKK
(231) DNA topoisomerase 3 [Vibrio vulnificus YJ016]
10
MTRLFIAEKPSLGRAIAAALPNPQKKEQGFIRCGNGDIVTWCIGHLLEQVEPDAYDERYKKWNMADLPIIPEQWQLRPRPSASKQLTVIRKLLKEASEVIHAGDPDREGQLLVDEVLDYCKLSQTKKAQTQRLLISDLNLPAVKRALSSLRSNRDFVPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPRDFFTLHALIPYQNGSEPFDIKARWKPSEACQPWQDEEGRVLSRKLVENVASRIANQPATVTESEHKQTKQAPPLPYSLSALQIDAAKRYGMSAQQVLDTCQSLYEKHKLITYPRSDNRYLPKEHYAQAASVSQAIANNAKELSDAVSGADLSLKSKAWNDSKVEAHHAIIPTPKQASVNALSGYEMKIYQLIARQYLMQFYPAATYAEAKLVFEIAGGVFIAKGRQLTFAGWKALTGATEKEEDGADTVPPLAKGTVLTCREGVIKDCKTEPPKHFTEATLLQAMTGIARYVSDKELKKILRETDGLGTEATRAGILDTLFKRQLLSRQGKAILSTPAGRGLIHALPQESTYPDMTAHWEHQLQGMAERNQAYQPFMAALQQRISELMQQVTTSPVPSSLRQLPPVERPAFKRKRRASTSKKTASTATQKRTNKSA
(1105) DNA topoisomerase 1 [Vibrio vulnificus YJ016]
9
MGKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTAGQSTGEKAAAISTKGMSVEEKARIKQKKDRNALIKKMGIDPYHDWAANYQILPGKEKVVSELQKLAKDADFVYLATDLDREGEAIAWHLREIIGGDETRYKRVVFNEITKNAIQQAFQKPGHLNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDIHANTLTQETMPFKLLVAQKSGDAFRPVNEAETKAALAVLQKAQFEVCKREDRPTKSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSQEAVEAVRGYISDEFGSRYLPKAPLVYGSKQGAQEAHEAIRPSDVNIKADALEGVDADAHKLYALIWNQFVACQMTEAEYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDTILPAVQVGDKLNLESLEPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEEKLDKIAEGDVNWKDVLNQFFADFTTDLGRAEEDEAHGGMKPNHIVMTDIQCPTCSRPMGIRTASTGVFLGCSGYALPVKERCKTTINLGDEEGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYLVEHGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHFPELPCSNSDAYFVLRDGAAGLFLAASNFPKSRETRVPLVSELARFAERLPEKYKHLAQAPTQDPDGVEAVVRFSRKTKENYVRTEVDGKPTGWTALYVDGKWEVTDKRKNAK
(64) DNA topoisomerase 1 [Baumannia cicadellinicola str. Hc (Homalodisca coagulata)]
9
MNKALVIVESPAKAKTINKYLGNQYLVKSSIGHIRDLPIHRETVKQQGKTNYQNTLANRMGIDPYNNWFANYEILPGKEKLVNELKALANKAKHIYLATDLDREGEAIAWHIREVIGGDNSKFSRVVFNEITCNAITQAFQSPRELNLHRINAQQTRRFMDRIVGYMISPLLWKKIARGLSAGRVQSVAVKLIVEREREIKQFSPIEYWDLYSYLQGPKDIVLKMQVTHLNNKPFKPINSLQVQSAIALLNNARYIVCCREDKITSSNPNAPFITSTLQQAASTRLGYSVKQTMLVAQRLYEAGYITYMRTDSTKISDEAINIVRNYILDIFGSKYLPNQPNQYLSKKNSLEAHEAIRPSNLHILAEQLENIEEDARKLYQLIWRQFVSSQMMPTQYNYTKINVIAGDFQLSTTGRTLHFDGWSKVMPILHKENEESICQSISVGQILSLQQLISQQNFTKPPLRYTEASLVKELEKRRIGRPSTYMSIIDSIQDRGYVKLNNHRFYAKKIGQIVTDRLAENFSELMNYDFTANMEDTLDKVATNQQDWKNVLDTFFIKLNQQLEKAKKSPTEGGMLPNSIVTTSINCPICGRMMGICTANTGVFLSCSGYKLPPKERCKHTINLISESEWLKKLDNENKSIDTQKVRSRCIKCNNIMDSYYFNNNSMLNICNNNPLCDGYEIEQGLCLLNTDYGTLVPCEKCSANMQLRIGRFGKYIACTNNTCKNTRNILRNGDIAPPKMELIEFPELPCKNSNAYFVLRNGAAGVFLAANTFPKVHETRAPLVEELVKFKDRLPTMLRYLTEAPIQDDQGNKTLVRFSRKKKQQYISSEKEGKATSWKAFFINGHWQVYNKEDQ
(804) DNA topoisomerase 3 [Photobacterium profundum]
10
MTRLYIAEKPSLGRAIAAVLPRPHKNNNGYIETGNGDIVTWCIGHLLEQVEPDAYDEKYKKWNMADLPIIPEQWQLSPRKSVKQQLAVVRKLAKQATDIVHAGDPDREGQLLVDEVIDYVKVSAKKKTEIQRLLISDLNPAAVKRALSTMRSNREFIPLSVSALARSRADWLYGMNMTRAYTLLGQKGGYRGVLSVGRVQTPILGLVTRRDDDIANFKPKPFYEVFALIPYQDMDIRARWKPSEACQPWQDEEGRVLNRQLCENVLKRIKGQPAEVTESERKETRQAPPLPYSLSALQIDAAKRFGMSAVDVLANCQSLYEKHKVITYPRSDSRYLPNEHFKQANDVCRAVASNASELSNACNGANTTLKSKAWNDKKVDAHHAIIPTPKQISPNALSGSESKVYQLIARQYVMQFYPAAIYAEAKLVFTITQGHFIARGRQLMSAGWRELLGRDHAEDKTKVAGNSDQGLTDKVPPLDKGTILTCREGEIKDKVTEPPKAFTEATLLQAMTGIARFVSDSSLKKILRDTDGLGTEATRAGILELLFKRQLLMRQAKNIHATDAGRGLVYALPDEATYPDMTAHWEHQLQDMADKKCAYQPFMDALQQQVSQLMDKVKYSEVPESLRQLTSPESRKPMKKKRYTKSKKS
(801) DNA topoisomerase 1 [Photobacterium profundum]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTGARNAGKKAAAQSTAGLSVEEKARLKKIKDRKSLIGKMGVDPYNDWDAHYEVLPGKEKVVSELQKLAADADFIYLATDLDREGEAIAWHLREIIGGDDARYKRVVFNEITKNAIQQAFEEPGELNIDGVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLIVEREREIKAFTPEEFWDIHANTLTVGKDALRLIVSQQAGKAFRPVNEAQTMAAKSVLDSAEYKVVDREDRPTSSKPSAPYITSTLQQAASTRLGYGVKRTMGLAQRLYEAGYITYMRTDSTNLSNDAVVAAREFIGSEYGENYLPKEAIKYGSKKNAQEAHEAIRPSSVEVQAENLEGMDADAVKLYDLIWRQFVSCQMVPAKYDSSTITVQADEFTLKAKGRILRFAGWTLVQRPSGKNEDTTLPIVHVGDVMILEGVEPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVRVDQRRFYAEKMGEIVSDRLDGSFPDLMDFDFTARMEGNLDKIAEGEKNWKAVLDNFFSDFTTELERAELDEDEGGMKPNNIVVTDIECPTCSRPMGIRTASTGVFLGCSGYALPPKERCKKTINLGDEDGIVNVLEEDVETAALRAKKRCPKCDTAMDAYLIDQDRKLHVCGNNPSCDGYIVEKGEFKLKGYEGPLIECDKCGSDMELKTGRFGKYMGCTNEDCKNTRKILKNGEIAPPKEDPVHLPEIPCTQDSNAYFVLRDGASGLFMAASTFPKSRETRAPLVSELVRFKDRLSPKFYYLAEAPTEDPDGREAVVRFSRKSKENYVRTEVDGKPSGWTGLYVDGKWEITDKRKKPKKEKAEKED
(1744) DNA topoisomerase 1 [Thioalkalivibrio sulfidophilus HL-EbGr7]
1
MSKHLVIVESPAKAKTIKKYLGPDFEVMASYGHVRDLVPKEGAVDPDHGFRMNYQVIDRNERHVESIVKALRKADSLLLATDPDREGEAISWHLYELLRERGVLDAKTVQRVVFYEITQRAVKEAIEQPRGLSFDLINAQQARRALDYLVGFKLSPLLWKKIKRGLSAGRVQSPALRMIVEREEEIERFQTREYWTLEADLDKSGQAFNAKLHTLDGKKLDQFDIADEVTASAARNTLLSAADGRLRVARIEKKQRRRNPAPPFTTSTLQQEAVRKLGFSASRAMRVAQQLYEGIDLGAGPIGLITYMRTDSVTLAGEAIAEIRRLIEQRYGRNTLPEHPRQYKTKAKNAQEAHEAVRPTSVMRAPEEVKRHLTTDQFKLYDLIWKRTVACQMQHATLDTVSADLAAGSERHLFRASGSSVRDPGFMAVYQEGKDDAKEESDERILPPLEEGDIVKLEALRAEQHFTEPPPRYTEASLVKALEEYGIGRPSTYASIISTLQQREYVEMDSRRFIPTDIGRIVNAFLTQHFTQYVDYDFTARLEDELDEISRGEKEWVPVMEGFWSSFKEQIEEKEATVTRAEAVQSRELGIDPKSGRPVSVRMGRYGPVVQIGTKDDEEKPRFAGLPPGKKMDAVTLEEALELFKLPRELGETPEGEPVSVNIGRFGPYVKFGSRYASLKPEDDPFSIELPRALELVAEKKEADANKYIRVFDEAGVQVVNGRYGPYITDGNKNARIPKDRDPKSLTLEECQALLAAAPERKGRRGVKKAAPKKKAAAPKKAAPKKKAAPRKKATAKKKAAPKKAAAKKNATSGGESGAGLTR
(1828) DNA topoisomerase [Thioalkalivibrio sulfidophilus HL-EbGr7]
4
MRVFLCEKPSQGKDIARVLGARQRGNGCYSGSGITVTWCIGHLVEAAPPETYGEQYKQWSIEQLPILPERWRIEVKAKTAAQFKIVKQFVAQAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALTQLKPGGETLPLYFSALARSRADWLIGMNLSRLFTVLGRRSGYQGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWTIDVTLSHAGQSFAASWMPPDGTTDAAGRCLQQPVAQQAADRIRAGRESKVLSVETERVREAAPLPFDLGTLQEVCSRQLGLDVQETLDIAQSLYETHKATTYPRSDSGYLPESMLAEVPTVLDALLATDPGLRPLIDRLDRTQRSRVWNDSKITAHHGIIPTLEPANLSAMSEKELAVYALIRAHYLAQFLPHHEFDRTLVMLDCAGQSLQAVGKRVIVPGWHLALPGKGQDAADDEPAQRSQILPPLDTGARCGVQQVELKALKTLPPKPYTQGELIKAMKGVAKLVTDPRLKQKLKETTGIGTEATRAGIINGLLARGYLVKKGRAIRASDAAFTLIDAVPAAITDPGTTAIWEQALDMIEAGQMTLDTFINKQSAWVAQLVQQYRGTVLSIKLPEGPACPVCGAATRQRNGKNGAFWSCSRYPDCKGTLPAESSTGRRRASRQRRAAPKAS
(1802) DNA topoisomerase 1 [Dichelobacter nodosus VCS1703A]
1
MSYKHLLIVESPAKAKTLHKYLGNDYEVLASYGHVRDLIPKNGAVEPENDFAMNYELIERNAKHVAQIEKALKNADELLLATDPDREGEAISWHLFELLQEKGVLAEKTVKRVVFYEITQRAILQAVSAPRDIEMNLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSPALRMIVEREREIDAFQAQEFWNITAHCQQKEEPFLAELTLFAGEKLEQFSFTDEQKTQTAIETLKKQAQGQLTVIDIVSKERKRNPAAPFTTSTLQQEAARKLRSSAQKTMRVAQKLYEAGYISYMRTDSVHLAQEAIEACRLLIEQQYGAVYVPPTPPVYTTKSKNAQEAHEAIRPTDITLEAAMLSAEMGADERQLYDLIRKRTLASQMAAAVMEQTSVDLSAGDTQNIFHATGSIIKFAGFMSVYLEDREESAEENMNLLPKMDIGDVIVLTDIIGSQHFTAPPPRFSEASLIKALEEYGIGRPSTYASIISTLQNREYVESSNRRFVPTTIGKVVNDFLTNHFQRYVDYDFTADLEDELDAIARGEQEWKPLLKDFWAQFKAQIEKKSEISREEVMQARELGMDPKTGKTVTARFGRFGPFVQIGSKDDAEKPLFASIPEDWDFEKISLENALELFKLPRNLGKTEEDEEIVINNGRFGPYVRFGRKFVSLPKDEDPLTISKERALELIALKKEEDRKKHIKEIKNGDDILQVLNGRFGPYVTNGSINASIPKHIEPAALTLEDALALLEKAQERKVNRKKKATEKTSEKKAKTTKTAKKAAPKKSTAKTKSTKQAEKGINHD
(78) DNA topoisomerase 3 [Dickeya dadantii 3937]
10
MRLFIAEKPSLARAIADVLPKPHRRSDGFIACGEQDVVTWCVGHLLEQAQPDVYDARYARWSLADLPIVPQKWLLQPRPSVSKQLNVIKKLLNQADEIIHAGDPDREGQLLVDEVLEYLSLPEEKRQHVGRCLINDLNPQAVERAVSRLRENREFVPLCVSALARSRADWLYGINMTRAYTLLGRNAGYEGVLSVGRVQTPVLGLVVRRDEEIDNFVSRDYFEVKAHIVTPADERFIALWQPSESCEPYQDEEGRLLHRPLAEHVVKRIEGQPAWVTAYNDKRESETAPLPYSLSALQIEAAKRFGLSAQQVLDVCQRLYETHKLITYPRSDCRYLPEEHFAGRQAVLNAIAAHQPDLLPQPAVDPERRNRCWDDGKVDAHHAIIPTARSARTSLTESESQVYGLIARQYLMQFCADAMFRKCVIDLDIAGGKFVAKARFLAEAGWRTLLGNKERDEENEGMPLPVVEKGDELLCERGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKALKKILRETDGLGTEATRAGIIELLFKRAFLVKKGRYIHSTEAGKALIHALPPMAAHPDMTAHWEATLTQISEKRCRYQDFMQPLTQSLHELIQQARQSGNITAFRGLPPVKRAPPAGRKRRQSRSASTKE
(253) DNA topoisomerase 1 [Dickeya dadantii 3937]
9
MGKALVIVESPAKAKTINKYLGNDFVVKSSVGHVRDLPTSGSGSASKKSAEANGEKAKKAVKKDEKTALVNRMGVDPYRGWQANYEILPGKEKVVSELKTLAQNADHVYLATDLDREGEAIAWHLREIIGGDDKRFSRVVFNEITKNAIRQAFENPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWELHADLLANPDIALQMQVTHHNGKPFRPVNQAQTQAAVSLLEKASYVVAEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALAMARDYIQDEFGKRYLPEAPNLYTSKENSQEAHEAIRPSDVKVLADQLKDMEADAQKLYQLIWRQFVACQMMPAQYDSTTLVVSAGDYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPAIDVGQSLSLEKLLPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMENSLDLVANSQAEWKAVLDEFFAEFSKQLETAEQEPDEGGMKPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLIPEAEVLNVLEGDEAETNALRARRRCSKCGTAMDSYLIDNQRKLHVCGNNPSCDGYEIEQGEFRLKGYDGPVVECEKCSSEMHLKMGRFGKYMACTNESCGNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFRDRLPEKLRYLAEAPVTDPEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYVDGKWVESSR
(769) DNA topoisomerase 1 [Nitrosococcus watsonii C-113]
1
MSKNVVVVESPAKAKTIKKYLGKNFEVLASYGHVRDLMPKEGAVDPEHGFKMKYQAIEKNGRHVNAIAKALKSADSLLLATDPDREGEAISWHLLELLKEEGVLEDKAIQRVVFYEITSQAVNEAVAHPRDISLDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIDAFKVREYWTLEADAAAAKQPFVAKLTHLDGRKLTQFDIENKDQALALVERLTKAAAGELWVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSAKRTMSVAQQLYEGVDIGDGAMGLITYMRTDSVNLANEAVGEIRNFIAERFGQNSLPVKSRTFKTRAKNAQEAHEAVRPTSVYRVPEALKPYLKPEQFKLYQLIWRRTIACQMNHATIDAVAVDLDTQKAAPERGEDARGNIFRATGSTVVDPGFMAVYQEGRDDAKGEEEQRKLPPMKEGDRVALLQIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRDYTVLESKRFQPTDVGRVVNRFLTEHFNPYVDYDFTARLEDELDAISRGEKVWIPVLEEFWGPFSARIQEKEQNVSREEAVQARELGVDPQSSRPVSVRMGRYGPYIQIGSKEDEEKPRFAGLQPGQKMDAITLEEALALFKLPRELGFTPGGERVSVNIGRFGPYVKYDNKYVSLRGEDPHTIPLERALVLIEEKRQADANRVIKVFPDSGIQVLNGRYGPYVTDGERNVRVPKEQAPEELSLEQAQTLIHEAPVKRARRKAGSRKKAKG
(459) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(305) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFLPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEEIYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(348) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Gallinarum/pullorum str. RKS5078]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(192) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Gallinarum/pullorum str. RKS5078]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(985) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEERLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(867) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(771) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLSVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(226) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(205) DNA topoisomerase [Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12]
4
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPWRTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKFQGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQYCDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQFVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVREKKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRKPSPA
(386) DNA topoisomerase 1 [Xylella fastidiosa 9a5c]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPENGFAMRYDLIDKNEKHVEAITKAAKTADSIYLATDPDREGEAISWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRMIASDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFITREYWSIHAECAHPAQHFSAKLIKLDGQKFEQFTITDSDTAAAAQRRIQQVAQGRLHITDVTNKERKRRPAPPFITSTLQQEASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDIIARDYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVWKRAVASQMIPAILNTTSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPVMKTGENVPLERILTEQHFTQPPPRYTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVDMEGRSFRPTDIGRAVSKFLASHFTRYVDYDFTAHLEDELDAISRGEEEWIPLMKKFWVPFKELVEDKKDSLDKTDAGSVRLLGIDPTSGKEVSGRIGRFGPMVQIGTVDDEEKPRFASLRPNQSIYSISLEEAIELFKMPRVLGEDQSQQVSVGIGRFGPFAKRGSTYVSLKSEDDPYTIDLARATFLINEKEEIARNRIIKNFENSQIQVLNGRFGPYISDGKLNGKIPKDREPASLTLEEAQQLLIDTGKPARKNFSTKKTATKNETRKQTTKKRTTDAKATKKVSDKPVKKQIKKRIAPNITE
(1779) DNA topoisomerase [Xylella fastidiosa 9a5c]
4
MTRRSSAGRWSSCPLFRSSGGSRSNRRPPRNSKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTVLGLQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSVPFWAIDVSLSAGGQAFSAQWVPPDGCTDDAGRCLQQPIAQQAAQQIRAASSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRPIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETTARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIVQYGSTSLSIKVPQGPACPQCGAPTRQRTGKTGPFWSCSRYPDCKGTLPVDSGTSKRGASRPRSSGRKGS
(580) DNA topoisomerase 3 [Haemophilus influenzae R2846]
10
MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGDNDVVTWCVGHLLEQAEPDVYDPKFKQWRLEHLPIIPEKWQLLPRKEVKKQLSVVEKLIHQADTLVNAGDPDREGQLLVDEVFSYANLSAEKRDKILRCLISDLNPSAVEKAVKKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQTGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVQAWVNPESKEEKTPEKSTALFSALWQPSKACEDYQDDDGRVLSKGLAENVVKRITNQPAEVTEYKDVREKETAPLPYSLSALQIDAAKRFGMSAQAVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHNVLNAISTHCEAYQRLPNVISTEQRNRCWNDKKVEAHHAIIPTAKNRPIHLTQEERNIYSLIARQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQTAGWKELLGKEDDTENQEPLLPIVKKGQILHCERGEVMSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLTKKGRNIHSTETGRILIQALPDIATQPDMTAHWESQLTDISQKQATYQQFMHNLNQMLPDLVRFVDLNALRQLSRIKMIKSDRAKPKSAVKKSSKSNGQTD
(1866) DNA topoisomerase 1 [Haemophilus influenzae R2846]
9
MSKSLVIVESPAKAKTINKYLGSQYVVKSSVGHIRDLPTVGSSTGEKAKPISTKGMDAEEKAKIKAEKERNALVKRMGIDPYHDWKANYQILPGKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGNNDRFSRVVFNEITKNAIKQAFEKPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWEVAVLTNNQNKQAIRLDVTDYKGKKFDPKNQKEAQSAVDFLNVSDYVVTDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMARSYIENHFGAQYLPEKPNFYSSKENAQEAHEAIRPSDIRALPESLEGMEKDAVRLYDLIWRQFLACQMPPAQYDSSTLTVSAGDYTLKAKGRILRFDGWTKVLPQIGKNPEDQELPSVTVSEKLALKEVQPTQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNESFGELMNYDFTANMEDTLDKIASGSVNWKTELNQFFKDFSSQLSKAELDELEGGMRPNNLVETDIKCPTCDRNMAIRTASTGVFLGCTGYALPPKERCKTTINLIPEAELLNVLDESSETKALMDRKRCTKCGTAMDSYVIDAHRKIHICGNNPNCDGYLIEEGSFKIKGYDGPVVECDKCGADMHLKLGRFGKYMGCTNCDNTRKILKNGEVAPPKEEPVHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRPVKIAELVQYRERLPEKLAYLADAPQKDPEENEAIVRFSRKEKKQYVTSEKEGKATKWIVDFTNGKWVERKK
(213) DNA topoisomerase 3 [Haemophilus parainfluenzae T3T1]
10
MRLFIAEKPSLGRAIADVLPKPHQRGDGFIKCGNDDVVTWCVGHLLEQAEPDAYDPKFKQWRLEHLPIIPEKWILLPRKEVKKQLSVVEKLIHQADVLVNAGDPDREGQLLVDEVFSYANLSAEKRDGILRCLISDLNPSAVEKAVQKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQAGYDGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFYEVLAWVKEEKTSENPTALFSALWQPSKACEDYQDEDGRVLSLGLAENVVKRITDQPAEVTEYVDKREKETAPLPYSLSALQIDAAKRFGMSAQSVLDTCQRLYETHRLITYPRSDCRYLPEEHFAERHKVMNAISQHCQTYQTLPLVVDTEQRNRCWNDKKVEAHHAIIPTANTRSINLSIDEQRIYELIARQYLLQFCPDAEYRKSKIILSIAGGTFVAQARNLQTAGWKELLGKEDEDENQEPLLPIVKKGQILYCERGEVVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLTKKGRNIHSTETGRILISALPDIATQPDMTAHWEAQLTDISQKQASYQQFMFTLNQMLPDLVRFVDFTALRRLSQISKGLSTPATKRKRAVKKSEDLNAEN
(1632) DNA topoisomerase 1 [Haemophilus parainfluenzae T3T1]
9
MSKSLVIVESPAKAKTINKYLGSQYVVKSSVGHICDLPTAGSSTGEKAKPVSTKGLSAEEKNKIKAEKDRAALVKRMGIDPYHDWKANYQILPGKEKVVAELKSLAKKSDHVYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKKAIEKAFQHPAHINMDQVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEFWEIEALTQTSKKEDLRLDVVQYKGKKFEPKNEKEAQSAVDFLNKSHYVVTDLETKPTGSKPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMARSYIESHFGKDYLPAKPNFYSSKENAQEAHEAIRPSDVKMLADHLSGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVMAGDYELKAKGRILRFDGWTKVLPQLGKNPEDQILPAVSLNETLALKTVSPSQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRIENRRFYAEKMGEIVTDRLNQSFTDLMSYDFTANMENVLDQIASGEKNWKAELNQFFKDFSTQLSTAELDELEGGMKPNSLVLTDIDCPTCSRKMAIRTASTGVFLGCSGYALPPKERCKTTINLIPETELLNVLDEASETKALMDRKRCPICGTAMDSYIIDPHRKLHICGNNPNCDGYLVEQGQFKIKGYDGPIVECDKCGSDMHLKLGRFGKYMGCTNCDNTRKILKNGEVAPPKEEPVHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRPAKVAELALYRDRLPEKLRYLADAPQKDPEGNEAIIRFSRKEKHQYVTSEKNGKATKWIVDYIDGKWVERKK
(881) DNA topoisomerase [Haemophilus parainfluenzae T3T1]
4
MKLFLCEKPSQGNDIAKILGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFKKWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLAGFRGQIKRLWLSALDDASIRKALGALKDNEETLPLYYAGLARSRADWLIGMNFSRIYTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQYVIPEQYCDPDGLCLSAQVIQAANQQIRQLGQAKMESVETKRERQNAPLCFALSDLQSEANRLYGLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPKIIQCLLQSDNRLQPLAGMLNLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYDLIRRRYLAQFLPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQALPTLKQGQICQISDSEIKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQGLIDKGFLKKKGKSLLATDEAMTLIDNLPQMLKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRHLMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFLGCSAYPNCQHIENFDSKKNTKGAKSSKKTSSKSVSEQISSLRSLLN
(481) DNA topoisomerase [Marinomonas posidonica IVIA-Po-181]
10
MILYIAEKPSLARAIAAALPGPQKKQEGCIWLPNGDCISWCIGHLLEQAEPHIYNPAFKTWQLDHLPIIPSDWQWQEKANTKKQLGILKKLIKQATQLVHAGDPDREGQLLVDEVLHYAKVPAQKLQQTQRVLISDLTPVAVKKSLQQLKSNAEFAALSRSALARARADWLFGLNLTRAYTIRGRQAGYQGVLSIGRVQTPVLGLVVARDTERENFVAKNYYQVWAQITTPENQHFQAKWLPSDACRPYMDEEGRVLNRALAKNVASRIENQPALVSQADYKQKKQPPPLPYNLSSLQIDAAKIFAMSAQQVLDTCQALYERHQIITYPRSDCRYLPTLQHRDAKAIINALSKGSEALAKSTKNANSNLKSKAWNDKQVTAHHAIIPTSQAHKAASLNKTESQIFGLIARQYLMQFYPDYQYLSTLIQLDIAGGKFEAKGSTPVALGWRSLLPTKKKSDHEEEQEQLPNLKKGDSLWCDQGIIRDKVTTPPAAFTDATLLAAMTGISRFVSDKSIKAILKETDGLGTDATRAGIIEILFKREFLIRQGKQIHASQTGRAFADTLPSQLVTPDMTAQWEAQLNAMSLGESRYQDFMAGLTDNLTDLLTQSKSVSTASLQHLPAPKRNPFKKRSATRKRSTKSKAKKPA
(1518) DNA topoisomerase 1 [Marinomonas posidonica IVIA-Po-181]
9
MGKSLVIVESPAKAKTINKYLGNDFVVKSSVGHIRDLPSGKTATSTPQERAKQAALTRKMSPEEKLEYKSRKSRKQLIARMGVDPEDNWHANYEVLPGKEKVVDELKRLAKNADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQSAFETPSELDLNRVNAQQARRFLDRVVGFMVSPLLWAKVARGLSAGRVQSVAVRLIVEREQEIRAFVPEEFWELDAMLSTSSDDMIKFEAAKYQGKEYRPVNQLQSDEHVARLQMAKYLVQSREDKPTKSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVESLRQYILSSFGEAYLPADPIRYSSKEGAQEAHEAIRPSDVNVRVDDLLGMEKDAHRLYDLIRSQFMACQMTPAEYTSTTITVVAEEYEFKAKGRILRFDGYTRAMQTVVKKGEDNILPDVTQGEFLDLKELLPEQHFTKPVARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGDIVTDRLVGSFSSLMDFSFTAQMEERLDEIAEGDKDWIQTLNAFYRDFSNVLAKAESPDDGMMLNEPTPTDVECPTCSRPMQIRTASTGVFMSCSGYALPPKERCKATINLIRGDEAVAVDDEEGESKALINKHRCKICGSAMDSYLMDEHRKLHVCGNNPSCTGYEVEAGSFKIKGYDGPVIECDKCSSEMQLKTGRFGKYFGCTNEECKNTRKLLKSGEVAPPKMDPVPMPDLACQKVEDHYVLRDGATGLFLAASQFPRKRETRAPYVKELIPYMDQIDPKYHFFADAPVADSEGRSTLIRYSRKTKEQYIMTENEGKPTGWKAFYDGGKWVIEEGKKKK
(716) DNA topoisomerase 3 [Actinobacillus succinogenes 130Z]
10
MRLFVAEKPSLARAIADVLPKPHSRGDGFIRCGENDYVTWCVGHLLEQAEPDAYNPSYKQWRLEHLPIVPQKWQLIPRKEVAKQLKIVEKLIHQADELVNAGDPDREGQLLVDEVFSYADLPADKKDKIQRCLVSDLNPNAVEKAVNKLQPNRNFIPLATSALARARADWLYGINMTRAYTIRGRQAGYNGVLSVGRVQTPVLGLIVRRDLEIENFRPKDFFEVLAQIKSEQNPTALSFTALWQPSKACEDYQDEDGRVLSRALAENVIKRITRQPAEVTAYEDKREKQTAPLPYSLSALQIDAAKRFALSAQDVLDTCQSLYEKHKLITYPRSDCRYLPNEHFADRHAVMNAISVHCTAYQTLPSAVNSEQKNRCWNDKKVEAHHAIIPTAKNRAVSLTAREQDIYGLIARQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQIAGWKELIGKEDDDEQLEAPLPVVKKGQMLFCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTEAGRILIQALPDLATQPDMTAQWEAQLNGISQKETSYQSFMFQLTQMLPELVQFVNFSALRRLSAVADRPKPTFKRKARKTADKSAVKSV
(639) DNA topoisomerase 1 [Actinobacillus succinogenes 130Z]
9
MSKSLVIVESPAKAKTINKYLGTNYVVKSSVGHIRDLPTAGASSGEKAKPISTKGLSVEEKSRIKAEKERNALVKRMGIDPYHDWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKNAIKQAFEKPEQLNIDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEFWEVAAELFTVHKAGIRLDVTAFKGKKFAPKNAEQAQSAVDFLAKSDFIVSDLETKPTSSRPRPPFITSTLQQAASTRLGFSVKKTMMLAQRLYEAGYITYMRTDSTNLSRDALGMVRGYIEQNFGDSYLPPKPNFYSSKENAQEAHEAIRPSDVNVSASHLSGMEKDAERLYDLIWRQFVACQMPAAQYDSTTLTVSAGDYELKAKGRILRFDGWTKVLPQMGKNPEDQELPAVALQEKLELGSVQPTQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFAELMNYDFTAGMEDMLDQIANGTKDWKAELNQFFKDFSGQLSQAELDELEGGMKPNSIVPTDIDCPACGRKMAIRTASTGVFLGCTGYALPPKERCKTTMNLIPESELLNVLDSETETKALMARKRCPKCGSAMDSYILDPHRKLHICGNNPNCDGYLVEEGAFKIKGYDGPVVACDKCGADMHLKLGRFGKYMACTNCDNTRRILKNGEVAQPKEEPIHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRESRPAEVAELALYRERLPGKLQYLADAPPKDPDGNDAVIRFSRKEKRQYVSSTDKNGKQTKWIVDFIDGKWIERSKK
(1604) DNA topoisomerase [Glaciecola sp. 4H-3-7+YE-5]
10
MILYIAEKPSLGRAIAQGFSGQQQKSDGYIKLANGDCVTWCIGHLLEQAEPDKYDPAYAKWALQHLPIVPQDWILVPKKGTSKQLSVIKRLLKTATKVINAGDPDREGQLLVDEVITYCKVKRDIIDNAGRLLINDLNLNAVKKSLTNIRPNREFTGLSISALARSRADWLYGLNLTRAYTLLGQRGGYSGVLSVGRVQTPVLGLVVRRDAEIAQFESKPFYDVIATLATQTSPSRQTFTAKWQPSAACEPYQDEEGRVIVKRLAETVVNKTRGQPGIVESYTVKDKQSPPPLPYNLSALQIDASKRYNLSPKAVLNVCQSLYERHQLITYPRSDSRYLPMEHFKDAQNVLSAIKANAPDQKSAVDNANSKLKSKAWNDSKVDAHHAIIPTSRRKALASLSGDEAKIYQLISTQYVMQFYGPHKYQEQVAVVTIAGGTFVAKAKATTDKGWLVLTKQSEAKQEPALPSLVKGQVLDCVDSQLVEKQTSPPKHFTEATLLAAMTGIARYVQDANIKKILKETDGLGTEATRASIIDLLFKRQFMQKSGKEIHATPTGKALVNALPSESTLPDMTAIWEANLDKISQRQMRYQDFMQPLTHTIGELINASQRIGTSQFAGLASTKPAYKKKWRKKKKAS
(829) DNA topoisomerase 1 [Glaciecola sp. 4H-3-7+YE-5]
9
MAKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGKVPPKKPAKELKLLSENKRESYLREHEYRKLVDRMGVDPKDDWAAHYEVLNGKEKVVNELKKLAKNADTIYLATDLDREGEAIAWHLQELIGDPSKDYQRVVFNEITKNAIQEAFSEPGKVNVERVNAQQARRFLDRIVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDVHANLLTAKDSDLRMQVAKYNDKAFKPTNKKQTDTALADLEGAEYKVISRDSKPTQSRPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSKEAVDACRDYIDDNFGAKYLPENALKYGSKEGAQEAHEAIRPSNVLLKSESLSEMERDAQRLYELIWRQFVACQMTPAKYDASTIRVSANGYELTAKGRVLKFDGWTKVQNPQRKKGEEDFLLPDVKEGESLSLKQLDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLESKRFYAEKMGEIVNDRLLENFDNLLSFDFTAKMEQELDEIANGKVSWKDVLNDFYGDFEKKLHLAEKDPDDGGMRLNQAVPTDIECPKCGRPMNVRTASTGVFLGCSGYNLPPKERCTGTMNLTSGDEVIKVDDEEELETELLRSKRRCPICSTAMDSYLVDETRKLHVCGNTPTCPGIEVEMGTFKIKGYDGPIIECDKCGSDMELKNGRFGKYFGCTNEECKNTRKLLRNGEAAPPKEDPVDLPELECTKSDAHFVLRDGASGIFMAAHNFPKSRETRAPLVAELARFRDRISPKFYYLADAPAKDPDGNDTLVRYSRKTKQQYVMSENEEGKATGWSAWYTDNKWTVEDKRKKAK
(721) DNA topoisomerase 3 [Glaciecola nitratireducens FR1064]
10
MIVYIAEKPSLGRAIATGFSGKQQKREGYIELDNGDCVTWCVGHLLEQAEPDKYDAAFAKWSLQHLPIVPDKWQLVPKKNTQKQLTVVKRLLKKATHIVNAGDPDREGQLLVDEVITYCGVKASIIENAGRLLINDLNTSAVKKALQNMRTNREFLGLSISALARSRADWLYGLNLTRAYTLLGQRGGYSGVLSVGRVQTPVLGLVVRRDQEIAHFVSKPFYEVIASLESQNKKTFNAKWQPSKACEPYQDEEGRVLSRKLAQTVVNKTRGQQAKVTDYKVQNRQSPPPLPFSLSVLQIEASKRFNLSPKMVLDVCQSLYEKHQLITYPRSDSRYLPKDQFGQASNVLGAIKSNVPNFASAVDNANPKLKSKAWNDSKVDAHHAIIPTNRSKAIGSFTQYEGKIYQLIANQYLMQFYGPHKYQEQVAKIDIAGGEFVAKGKSSQDLGWLALTKNQNNASDDNKNDTLLPQLNKGELLKCTDSQLMEKQTSPPKHFTEATLLAAMTGISRYVQDRNIKLILKETDGLGTEATRATIIDLLFKRQFMQKVGKEVHATETGKALINALPSETTYPDMTATWEADLDKIAQRQLRYDGFMQPLTESIARLIDNSQQLDSRQFAGLKSSKPTRKKRYFKKKSS
(763) DNA topoisomerase 1 [Glaciecola nitratireducens FR1064]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGLVEPKKPAKELSKWTDKKKAEYLKDYEYQKLVDRMGVDPKQNWMAHYQILQGKEKVVAELKKLAKDADTIYLATDLDREGEAIAWHLQELLGSKGKTYQRVVFNEITKNAIQEAFSDPGVVNINRVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDIHADLSTQKKDALKMLVAKHKGAAFKPINKKQADEAVSALENADYTVTSRESKPTQSRPSAPFITSTLQQAASTRLGYGVKKTMTMAQRLYEAGHITYMRTDSTNLSKDAVEGCRNYIQKNYGDKYFPSNPLTYGSKDGAQEAHEAIRPSNVAVKADSLKEMERDAQRLYELIWRQFVACQMTPAKYDATTIRVEANNYELTAKGRVLLFDGWTAVQPQIKRKGDNELLLPDVKQGDTLKLNELDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVKLDSKRFYAEKMGEIVNDRLVENFSDLISFDFTAKMEQRLDDIAHGETKWKSVLDNFYSEFSEQLENAEKSVEDGGMKLNQAVPVDIECSKCGREMNIRTASTGVFLGCSGYNLPPKEKCTNTMNLTPGDEVIKVDDEEELETEVLRAKRRCDKCGTAMDSYLVDENRKLHVCGNAPSCEGVFVEQGTFKIKGYDGPIIECDKCKSNMELKTGRFGKYFGCTNEECKNTRKLLRSGEAAPPKEDPVFLPELECEKSDAHFVLRDGAAGLFLAAHTFPKSRETRAPLVEELARFRDRISPKFYYLADAPKADPDKNPTIVRFSRKTKQQYVMSEDGKGKATGWSAWYENGKWVADDKRKKAKKEPKK
(1133) DNA topoisomerase 1 [Shewanella frigidimarina NCIMB 400]
9
MESIFFFSRLFGANKTMGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSTSDGTTVTKTAAEVKKLSPEEKAKYKLIRDKQALVARMGVNPDKGWAAKYQILPGKEKVVKELKALAETADQIYLATDLDREGEAIAWHLQEIIGGDPSRYQRVVFNEITKTAIQDAFSKPSVLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDIHAELNTPTAASLKMQVMKYQSAAFEPINEAQAKVAVDALRDATYVVTAREDKATSSKPSAPYITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSKEAVENLREMIAAEFGDKYLPAEPIRYGSKEGAQEAHEAIRPSNVAVQSASLTDMERDAQRLYELIWRQFVSCQMTPAQYDATRLTVTAGDYELKASGRTLRFDGWTRVQPQVSKKNEEDKTLPVVAKGDKLVLETLSPKQHFTKPAPRYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVDNRRFFAEKMGEIVSERLVGSFKELMSYDFTASMEQTLDDVAQGKLDWKKVLDGFYGDFTKQLLLAELDPDEGGMRPNEMVLTDDIKCPTCCRPMGIRTGSTGVFLGCSGYALPPKERCKTTLNLTPGEEAVSDNEDGETEALRAKHRCGKCGTAMDSYLIDETRKLHVCGNNPSCDGYEVEAGQFKIKGYEGPIIECDRCGNNMELKNGRFGKYFGCTNSECKNTRKLLRSGEAAPPKEDPIFLPELKCTKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVQYRDLLWPKYAYLADAPVEDDEGNKASVKFSRKTKEQYVATEVDGKATGWSSKFIGGKWVSESTKKKAKK
(1363) DNA topoisomerase 3 [Shewanella frigidimarina NCIMB 400]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFITAANGDCVSWCIGHLLEQAEPDAYDDAFKSWKLEHLPIVPQTWKLQPKPKTRSQLTVLRKLVKHASSIINAGDPDREGQLLVDEVISYLGVKGDKLNQVQRLLISDLNPQAVKRALGQLRKNREFVPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPLLGLVVRRDDEIADFTPKAFYEVLAHLLTDQQQAFTAKWQPSEACQPYMDEDGRVLAKGLAENVVARINDKPAEVTKIEAKDKRQNPPLPYSLSALQIDAAKRFGLSAKEVLDTCQSLYERHKLITYPRSDSRYLPKEQHALAPKVLDAVLKGASGLIEGCESPNSKLKSKAWDDSKVDAHHAIVPTEKVANLSTLSSNEAKLYQHVARQYLAQFYPAYIYAETAVEVTIAGGLFTTKARQDKTLGWKQLFKRTATVNQASSNSTSSDDDNDDAVLSLPPLVKGQILHCQRGELLQKMTQAPKHFTDATLLGAMTGISRYVTNSEIKKILKETDGLGTEATRAGIIELLFKRGYLVRQGKSILATPVGVGLIRSLPESATTPDMTALWENSLDAISQKRLKYDAFMQPLLSQLDGLITQASSQLPSALQGVASSAPKRSFKKSYKKKAKAKS
(71) DNA topoisomerase 1 [Alcanivorax borkumensis SK2]
9
MGKSLVIVESPAKAKTINRYLGDDFIVKSSVGHVRDLPVSGGSKKSTPQERAKEAAYTRSLPKEERDAYKKKKAKKQLINRMGIDPENGWAAHYEVLPGKDKVVDELKRLAAKADRIYLATDLDREGEAIAWHLREVIGGDEERFDRVVFNEITKKAIQAAFEEPGKLDLHRVEAQQARRFLDRVVGFMISPLLWEKIARGLSAGRVQSVAVELVVEREREIRAFIPEEFWELYSDTHSGDGEALRLQVAKHNGLAFRPNNGDDAAAHKQALENAGRLTISQREQRPTRSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSSDAVAACREWIGEKLGDKYLPDEPLSYSSKEGAQEAHEAIRPSDVRRTSDSLKDMERDAQRLYELIRRQFIACQMPPAEYLSSTLTAIGNGYELKAKGRIMKFDGWTRIQPPASRKGQEDTLLPDVKEGDVLAIDNVDANQHFTKPPARFTEASLVKELEKRGIGRPSTYAAIISTIQDRGYVRQDNRRFYAEKMGDIVTDRLVESFPNLMDYGFTASMEETLDEVAEGRRNWQDVLNEFYKDFVSKLDAAQGEGTGKQAVGGMRANLPTDTDIECPSCGRPMQIRTGSTGVFLGCSGYALPPKERCTATLNLLPGEEAEAVKTDDDEEAETNELRSKKRCQKCGTAMENYLIDEKRKLHICGNNPDCDGYVIEKGEFRIKGYDGPVLECEKCGNDMQLRTGRFGKFFKCTNDECGNTRKLLKSGEPAPPRADPIPMPHLQCQKVDDHYLLRDGASGLFLAASKFPKNRETRPPLIEEIQSVAEQLDPKHAYLAQAPATDPDGNKGVLRYSRKAKEQYVMSEIDGKATGWMAFYRDGKWVEEQAKKKAPAKKKAAAKKKATKKKAAAKK
(1519) DNA topoisomerase 1 [Kangiella koreensis DSM 16069]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSIGHIRDLPTGSQNKKPVDAKERARKAAATRKLSPEQKAKQKALKEKTALFARMGINPEHDWEARYEVLPGKEKVLNELKKFAKDADTIYLATDLDREGEAIAWHLRELLDGKETQFKRVVFNEITKKAIQQAFAKPGDLDMNYVNAQQARRFLDRVVGFMVSPLLWRKISRGLSAGRVQSVAVRLLVEREREIRAFIPEEYWDIHANTLTQSKDDLRLQVNKYQGKNFRPNSEQETNKALEVLKSSSYKVVTREDKPQKSKAPKPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTYLSTDAVDACRDYIKTNIGAEYLPKEANSYSSKEGAQEAHEAIRPSDVTKKVGHLSGMEKDAERLYDLIWRQFVACQMLPAEFDVTSLKVQAGDYELKARGRVMRFDGWTQVLPMQKKNAEDEELPNVKEGELLELKKLDPKQHFTKPPARFSEAALVKELEKRGIGRPSTYASIISTIQDRGYVRIENRRFYAQKIGEIVTDRLVESFSDLLDFSFTATMEKHLDDIASGRQNWKVTLDEFYDEFSQQLKKADEEEGEGGMRRNEAVETDILCDKCKKNHMAIRNASTGVFLGCMGYSLPPKERCKNTVNLIPGEEFIAADEEEEARYLHDKKRCTKCNSTMDDYLVDENTKLYICGNNPDCDGYEIEKGEFKIKGYDGPILECDKCGSEMQLKTGRFGKYFDCTNDDCKNTRKLLKSGQPAPPKADPIPMPELQCEKVDDHYVLRDGAAGIFLAASKFPRNRETRAPAVDELVTVKDKLDPKYKFLGEAPLKDPDGNRTFVKFSRKTGQQYVAGVKEDGKASGWTAFYENGKWVPQK
(33) DNA topoisomerase 1 [Hahella chejuensis KCTC 2396]
9
MTAISTRSKEPSAMGKSLVIVESPAKAKTINKYLGSEYVVKSSVGHIRDLPTSGGKETSSPKERAAEAAKMRKLPAEERESIKKRKARDQLISRMGVDPENDWAARYEVLPGKEKVVEELRRLAKSADQIYLATDLDREGEAIAWHLKESIGGDDSRYRRVVFNEITKSAITEAFKSPGQLDYNRVNAQQARRFLDRVVGYMVSPLLWSKIARGLSAGRVQSVAVRLIVEREREIRAFTPEEYWELHALLSKSKQQAKFQVAKYKGENYRPTNKAQSDKLTALLQTQAFKVVNREDKPSVTKAPAPFITSTLQQAASTRLGFSVKKTMVLAQRLYEAGYITYMRTDSTNLSADAVNACREFIGKKFGDKYLPDNPKTYVSKERAQEAHEAIRPSDINVGANQISGLEKDAEKLYDLIWRQFVACQMENARFLSTSIQVQAGDFELRTRGRLLQFDGFLKVLPAQAKKDDEAELPAFEVNDQLDLDKLEPTQHFTKPAPRYTEATLVKELEKRSIGRPSTYASIISTIQERGYVKLANRRFYAEKMGDIVTDRLTEAFTDLMDYGFTAKMEGQLDEIASGNEGWKQVLNAFYSDFAKKLEKADMEGGMRANQAVQTEIACPTCSRPMQIRTASTGVFLGCSGYALPPKERCKTTINLIPGDEVIRADDEEGEANALRAKKRCPICDTAMDSYVIDETRKLHVCGNNPDCEGYEVEGGQFKVAGYDGPTLECDKCGAEMQLKTGRFGKYFGCTSSTCGNTRKLLKNGEPAPPKMEPVVMPELACDKVDDIFVLRDGASGLFLAASKFPKNRETRAPLVEELIPHKKEIDPKHHYLLEAPTRDPEGNPAIIRFSRKTKQQYVMSEKGGKPTGWSAFYKDGKWVAKDK
(1721) DNA topoisomerase 3 [Shewanella woodyi ATCC 51908]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGHIIAGNGDCVSWCIGHLLEQAEPDAYDPEFKSWKFEHLPIVPDSWKMKAKPKTRSQLTILKGLIKQASQLVNAGDPDREGQLLVDEVIAHFGVKGDKLHQTKRLLISDLNPQAVKRALGQMRSNREFIPLSTSALARSRADWLYGLNMTRAYTIQGRKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFVSKPFFEVLANLSTEHNEHFKAKWQPSEACQAYMDEEGRVLSKGLAQNVVGRITEQPACVVGLDSKDKKQNQPLPYNLSSLQIDAAKRFGMSAKEVLDTCQALYEKYKLITYPRSDSRYLPIEQFSMAPSVIKAVLSGASELVIGPEQPDSKIKSKAWNDKKVDAHHAIIPTEKTANLAGLTPRERQIYLQLARQYLAQFYSPYQYHETLVEVEIAGGKFKTKAKQDKSLGWKQLFAKKGEKLEEKGSAVGDSSDDDLDALQKLPQLKKGQALHSGQGELIEKQTQAPKHFTDATLLGAMTGINRYVTDPEIRKILKDTDGLGTEATRAGIIELLFKRNYLSRSGKSIVATDVGKGLINSLPMSATTPDMTALWESNLDAISRKEAKYINFMSPLVDSLAQLITQAGAQLPTSLQGIKAPKSNFKKRAYSRKKTTKSAAKPSGRRATKVS
(342) DNA topoisomerase 1 [Shewanella woodyi ATCC 51908]
9
MEPIYKFLRLFGADHSMGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSTAEANVATKTPAEVRKMSPEEKAIYKSKRAKQALVTRMGVDPENGWKAKYQTLPGKEKVVKELQALAASADHIFLATDLDREGEAIAWHLQEVIGGDASRYQRVVFNEITKSAIQDAFSKPATLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEKEGEIKAFVPEEFWDIHANLTTLANDALKMEVVKFQEKAFNPVNELQAQTAVSALSQSSFVVAAREDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVDNVREMIGKEYGDKYLPDAPIRYGSKEGAQEAHEAIRPSDVSVHAAGMKDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGEYELKATGRTLRFDGWTRVQTAVKKKNEEDNTLPVVAKGDVLSLEELLPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLIGSFKELMSYDFTASMEQTLDDVAQGELEWKKVLDGFYQDLTKQLDQAELAPEEGGMRPNEMVLTDIKCPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTAGEEAVSENSEDAETDALRAKHRCGVCGTAMDSYLIDETRKLHVCGNNPICGGYEVELGQFKIKGYEGPIIECDRCSNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFMAASTFPKSRETRPPLVEELVKYRELLWPKYAYLADAPVEDDDGNKSTVRFSRKTKEQYVATEVDGKATGWTSKFVDGKWVTESKKKAKPKAKPKAKAKAKS
(907) DNA topoisomerase 3 [Shewanella amazonensis SB2B]
10
MRPPGIFATFTVNSSSAFAPEYPAMILYIAEKPSLGRAIAEVLPKPHKKGEGYIELGNGDCVTWCIGHLLEQAEPDAYSPEYKQWQLAHLPIIPAEWKLTPRSSAKSQLAVVKRLIKQASSLVHAGDPDREGQLLVDEVISHAKVSASKLASTQRLLISDLNPDAVRRALGQLRSNKEFVPLATSALARSRADWLYGLNMTRAYTLQGRKVGYAGVLSVGRVQTPLLGLVVRRDLDIEHFEPKDHYEVLAHITTDKGESFCAKWQPSEACQPYMDEEGRVLSRRLAETVVSRIGGKPALVEHVSHKDKKQAPPLLYSLSALQIDCAKRFGMSAKEVLDTAQSLYERHKLITYPRSDSRHLPKEQLALVPDVLSAVSANAPELLEGAPSPDLHLVSKAWDDSKVDAHHAIVPTGKRTALSQLNQRERQLYLHIARQYLAQFYPNRLLADTEIQLIIEGGSFIARASVERAPGWRVLFQGRSTEQDEAKEPQETDASQKTPLPALNKGDIARCCHGELLAKQTQPPKHFTDATLLSAMTGIARYVSSPDIKRILKDTDGLGTEATRAGIIELLFKRGFLVRQGKSIVASQAGRGLIASLPEVATTADMTALWERQLSDICQRQLSYKGFMTPLVLELEKLIEQAAASLPTALAGVTAAGPKRSFRGRAGKGKGRAPGASAGRGRKSRSSPSGKVAT
(1421) DNA topoisomerase 1 [Shewanella amazonensis SB2B]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSAAEGKASTKSAAEVRKMNPEEKAKYKAQKDKQALVARMGVDPEHGWQANYQVLPGKEKVVKELQSLASSADQIYLATDLDREGEAIAWHLQEVIGGDESRYKRVVFNEITKGAIQEAFSRPTDLNTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREAEIKAFVPEEFWDVHATLSTPAAAELVMEVSRYRNEAFEPVTQSEAMAAVNALEKAAFTVTDREDKATSSKPSAPFITSTLQQAASTRLGFGVKKTMMLAQRLYEAGHITYMRTDSTNLSQEALENVRAHIEKEFGSKYLPESPIRYGSKEGAQEAHEAIRPSNVKVESATLIDMERDAQRLYELIWRQFVACQMTPAVYDATRITAKAGDYELKASGRILKFDGWTRVQPALKKKNEEDNTLPDVQVGDMLSLKALDPKQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVKVENRRFYAEKMGEIVTERLVESFSELMNYDFTAGMEQTLDDVAKGDKDWKGVLDGFYSGFTAKLEKAEAEPDAGGMRPNQMVLTDIPCPTCGRQMGIRTGTTGVFLGCSGYALPPKERCKTTLNLTPGEEAISDSSEDAETDALRAMHRCGKCGMAMDSYLLDETRKLHVCGNNPECDGYEVEKGAFKLKGYEGPIIECDRCGSDMELKNGRFGKYFGCTNESCKNTRKLLKNGEAAPPKEDPIHLPELKCTKSDAYFVLRDGAAGIFLAASTFPRSRETRAPLVEELKKYREALWPKYQYLADAPVEDAEGNKALVKFSRKTKEQYVATEVNGKATGWSAHFKDGKWVESK
(713) DNA topoisomerase 3 [Shewanella oneidensis MR-1]
10
MILYIAEKPSLGRAIADVLPKPHKKGEGFIEDANGNCVSWCVGHLLEQAEPDAYNPDFKSWKFEHLPIVPEKWQLKPKAATRSQLTVLKKLIKQADTLVNAGDPDREGQLLVDEVIAYLGVTGDKLQQTQRLLISDLNPQAVKRALSQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLIVRRDEEIAHFQSKPFYEVLAHLVTDKQQFFSAKWQPSEACQPYMDDEGRVLSKGLAQNVVRRITDKPAKVTQLSTKDKQQSAPLPYSLSALQIDAAKRFGMSAKEVLDTCQSLYERHKLITYPRSDSRYLPTEQHGLASSVLNAITSGAPELVAHSEAPNPRLKSKAWDDKKVDAHHAIIPTEKQPNLGSLSQRERQLYLHIARQYLAQFYPAYCYSETAVEVTIEGGLFKTKARQDKSLGWKQLFAREEGERKDTSNTETFAQDDKDKDEGEYAGQLPPLILGQVLHCNQGELVEKQTQPPKAFTDATLLGAMTGINRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFIQRQGKSIVATEVGKGLINSLPLSATTPDMTALWEASLNGICHKDISYQGFMQPLLGTLHSLIQNAGAQLPSALNGLKGQGFKRAATKKSGYRKAGVRGAAGGKKAGTGAKNARNSAAASSTSTTAKPTVPRRRTSKATAQA
(1060) DNA topoisomerase 1 [Shewanella oneidensis MR-1]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSISDGTEKVKSAAEVKKMSPEEKARYKKVKDHQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQEAFSKPASLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAQLNTPSSEALRMEVVKYLDSAFEPTNEQQALAAVQALSSASFKVIAREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDSVREMIGKEYGAKYLPAEPIRYGSKEGAQEAHEAIRPSNVKVEAAALTDMERDAQRLYELIWRQFVSCQMTPALYDATKLTVKAADYELKATGRILRFDGWTRVQTAIKKKNEEDNTLPAVNEGDVLSLVELEPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQERGYVKVENRRFYAEKMGEIVSERLVNSFAELMSYDFTASMEQTLDDVAKGELDWKKVLDGFYADFTKQLEKAELAPEEGGMRLNQMVMTNIKCPTCGRPMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGIEAISDSEDAETDALRAKHRCGICGTAMDSYLLDEKRKLHVCGNNPVCEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNEECKNTRKLLKNGEAAPPKEDPIYLPELKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYREFLWPKYQYLADAPIADDDGNKAVVKFSRKTKDQYVATEVDGKATGWSAHYVNGKWVSESSAKKAKK
(1252) DNA topoisomerase 1 [Nitrosococcus halophilus Nc 4]
1
MSKNLVVVESPAKAKTIKKYLGKDFEVMASYGHVRDLMPKEGAVDPEHGFAMKYQVIEKNSRHVDAIAKALKKADALLLATDPDREGEAISWHLLELLKERGALEGKSIKRVVFYEITQQAVNEAIAHPRDISSDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIEAFKIQEYWTLEADAAASKHPFVAKLTHLDGHKLGQFDIDNGDRAQALVEQLTKAASGELLVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSTKRTMSVAQQLYEGVDIGDGAVGLITYMRTDSVNLANEAVKELRDFIAGHFGEKSLPAKPKTFKTRAKNAQEAHEAIRPTSVYRTPEELKPHLKPEQFKLYQLIWRRTIACQMNHATIETVAVDLDTRKSVPEKGVSNTGSNIFRATGSTVVDPGFMAVYQEGRDDTKAEEEQRILPPMKEGDRVELVRIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRSYALLENKRFHPTDVGRVVNRFLTEHFNPYVDYDFTARLEDQLDAISRGEKVWIPVLEEFWEPFLGRIQEKEQSVSREEAVQARELGIDPKSGRPVSVRIGRYGPYVQIGSKEDEEKPRFAGLRPGQKMDTITLEEGLALFELPRELGFSPEGEKVSVNIGRFGPYVKYDNKYVSLRGEDPYTIALERALELIQEKKQADANRVIKVFPDSGIQILNGRYGPYVTDGERNARVPKDQAPEKLSLEQAQTLINEAPAKRARRKTGTRKKAKG
(1296) DNA topoisomerase 3 [Shewanella sp. W3-18-1]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFIEAANGDCVSWCVGHLLEQAEPDAYNPEFKAWKFEHLPIVPDKWQLTPKAATRSQLTVLKRLVKQASMLVNAGDPDREGQLLVDEVIAYLGVTGDKLHQTQRLLISDLNPQAVKRALTQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDKEIANFQSKPFYEVLAHLATDKQETFSAKWQPSEACQPYMDEEGRVLARGLAQNVVSRISDKPALVTQLVAKDKKQHPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPVEQHNLAPSVLKAISDGAAELLQGADAPDPRLKSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHIARQYLAQFYPAYCYSETTVQVTIEGGLFNTKARQDKSLGWKQLFARQEPNGSKASGNKSTEESAGKDDEEHDEFIGQLPPLKLGQALHCTRGELLEKNTQPPKAFTDATLLSAMTGISRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVSTDVGKGLINSLPLSATTPDMTALWEASLNGICHKETSYQGFMQPLLGTLSTLIQNAGAQLPTALNGLKGQGYRKTASHKSGYRKSYSKKSSSAKGIGTTKNDVSNKYGSQKTSSKSSVTRSTSRSASNSRKSTAAV
(1556) DNA topoisomerase 1 [Shewanella sp. W3-18-1]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSEGNEKVKSAAEVKKMSPEEKAQYKKVKDQQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAQLTTPAEESLRMEVVKHLDSAFEPINEQQALAAVQALSSASFKVISREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALESVRDMIGKAFGAKYLPAEPIRYGSKEGAQEAHEAIRPSNVHVEATDLTDMERDAQRLYELIWRQFVSCQMTPAQYDATKLTVKAGDYELKATGRTLRFDGWTRVQTVLKKKNEEDNTLPFVSQGDVLALKELQPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSERLVSSFADLMSYDFTASMEQTLDDVARGELDWKKVLDGFYADFTKQLEKAERDPEEGGMRLNQMVMTDIKCPTCGRPMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGVEAISENSEDAETDALRAKHRCGICGTAMDSYLIDEKRKLHVCGNNPICEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNEECKNTRKLLKNGEAAPPKEDPIYLPELKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPICDDEGNKAAVKFSRKTKEQYVATEVDGKATGWSAHYINGKWVSESTAKKSKKA
(823) DNA topoisomerase 3 [Shewanella loihica PV-4]
10
MILYIAEKPSLGRAIADVLPKPHKKGEGYITAANGDTVSWCIGHLLEQAEPDSYDPAFKSWSFDHLPIVPQQWKMTPKSKTRGQLSVLRKLVKQASQLVNAGDPDREGQLLVDEVIAYLGVKGDKLEQTQRLLVSDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTLQGRKVGYQGVLSVGRVQTPLLGLVVRRDEAIEHFVSKPFYEVLANLYTQEQAHFKAKWQPSEACQPYMDEEGRVLSRRLAENVVGRITEQPAKVTDLQAKDKQQGQPLPYNLSSLQIDAAKRFGMSAKTVLDTCQSLYEKHKLITYPRSDSRYLPKEQLALAPSVIGAVLKGAGELTAQCAAPDLKIVSKAWNDAKVDAHHAIVPTEKVANLSALTQAEKQIYLQLARQYLAQFYPVYRYHETQVEVEIAGGHFHTKAKQEIALGWKQLFPKRSDDKTDGEGDEALAQLPPLHKGQMLHSGQGELIEKQTQPPKAFTDATLLSAMTGISRYVTNPEIRKILKETDGLGTEATRAGIIELLFKRGFLARQGKSIVSTPVGRGLINSLPESATTPDMTALWESHLDAISRKEAKYLSFMAPLVESLNGLIMQAGAQLPKALQGVEAPKRSFKKRGYGNRRGTATGAKGKASGAKKTAARAASKTRAKTSA
(325) DNA topoisomerase 1 [Shewanella loihica PV-4]
9
MEPIYRILRLFGADHSMGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSSSDASSSTKSPAEVRKMSTEEKAKYKADKAKKALVARMGVDPERGWKAKYQTLPGKEKVVKELQSLAENADHIFLATDLDREGEAIAWHLQEVIGGDPERYQRVVFNEITKSAIQEAFSHPSQLNTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEREGEIKAFVPEEFWDIHAELTTLGNEGLKMQVAKFKGDNFNPVNEAQAMVAVNALKDSKYQVSSREVKATSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDSVRDMIGKEYGDKYLPDAPIRYGSKEGAQEAHEAIRPSDVNVSATSLSDMERDAQRLYELIWRQFVACQMTPAKYDATRLTVTAGDYELKASGRTLKFDGWTRVQTALKKKNEEDNTLPMVAEGDVLALEELLPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLIGSFEELMSYDFTAGMEQTLDNVAQGQLEWKKVLDNFYKGLTAQLEKAELPPEEGGMRPNEMVLTDIACPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSENSEDAETDALRAKHRCDVCGTAMDSYLIDEKRKLHVCGNNPICGGYEVEQGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNSECKNTRKLLKNGEVAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPVADEDGNKAVVRFSRKTKEQYVATEIDGKATGWTAKFVGGKWVSEAKAKPKAKKKA
(522) DNA topoisomerase 3 [Shewanella piezotolerans WP3]
10
MILYIAEKPSLGRAIADVLPKPLKKGEGFIRAANGDCVSWCVGHLLEQAEPDAYSPEYKSWKFEHLPIVPDVWKMKPKYKMRGQISVLRGLVKEATQLVNAGDPDREGQLLVDEIIAHLGVKGNKLTQAKRLLISDLNPQAVKRALGQLRLNREFIPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPILGLVVRRDEEIAHFVSKPFFEVIAHLTAEPQQTFTAKWQPSEACQPYMDEDGRVLSKGLAQNVVGRITGQPATVEKVNAQDKKQNAPLPYNLSSLQIDAAKRFGMSAKTVLDTCQSLYERHKLITYPRSDSRYLPQEQHGMAPSVINTVNKGAPELTQGIDAPNAKLKSKAWNDKKVDAHHAIIPTEKVANLSSLSPAEKQVYLLVARQYLMQFYSAYQYKETQVEIIIAGGLFKTKAKQEIAKGWKLLLKQSKASTSSDSNGQDEDELATIPPLTIGQKLFCDRGQLLEKQTQPPKHFTDATLLSAMTGISRFVTDVEIRKILKDTDGLGTEATRAGIIELLFKRSFLVRQGKTIVATDVGKGLINSLPLSATTPDMTALWENNLDSMSRKETQYQAFMQPLISKLDELITQAGSVLPTALQGVKSPTPFKKKSYARKGGKGQSTTKKNVGKPRMAKS
(854) DNA topoisomerase 1 [Shewanella piezotolerans WP3]
9
MEPIFRFLKLVGANKYMGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSSPDAKVVSKTPAEVKKMSPEEKAEYKSLKAKQALVARMGVDPEKGWKAKYQTLPGKEKVVKELQTLAESADHIYLATDLDREGEAIAWHLQQVIGGDESRYQRVVFNEITKSAIQDAFSQPSVLDTNMVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVRLVVEREGEIKAFVPEEFWDVHAELNTLCDERLKMQVAKFQGKAFNPVNQTEADAAVSALSQSSFVVAGREDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVREMIGKEYGDKYLPEAPIRYGSKEGAQEAHEAIRPSNVKVTAASLSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVAAGDYELKASGRTLRFDGWTRVQTAIKKKNEEDNTLPVVAKGDTVTLQELMPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVDNRRFYAEKMGEIVSDRLVGSFQDLMSYDFTASMEQTLDDVAQGKLDWKKVLNGFYKDFTKQLENAELPPEEGGMRPNEMVITDIKCPTCGRPMGIRTGSTGVFLGCSGYALPPKERCKTTLNLTPGEEAVSESGEDAETEALRAKHRCGICGTAMDSYLIDETRKLHICGNNPTCEGFEVEAGQFKIKGYEGPIIECDRCQNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPDLKCTKSDAYFVLRDGAAGIFLAASTFPKSRETRGPLVEELVKYRELLWPKYAYLADAPVADDDGNLASVRFSRKTKEQYVATDVDGKATGWTAKFIDGKWVAEAKAKAKPKAKAKPKAKPKAKAKPKAE
(629) DNA topoisomerase 3 [Shewanella baltica OS155]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFIEAANGDCVSWCVGHLLEQAEPDAYNPEFKSWKFEHLPIVPDKWQLKPKAATRSQLTVLKRLVKQANTLVNAGDPDREGQLLVDEVIAYLGVTGDKLHQTQRLLISDLNPQAVKRALTQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFQSKPFYEVLAHLATEKQETFSAKWQPSEACQPYMDEEGRVLARGLAQNVVSRISDKPALVTQLVAKDKKQNPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPVEQHSLAPSVLKAISGGAAELLQGADAPDPRLKSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHVARQYLAQFYPAYCYSETTVQVTIEGGLFNTKARQDKSLGWKQLFARQEPNGSKASGNKSTEENAGKDDEENDEFIGQLPPLKLGLALHCTRGELLEKNTQPPKAFTDATLLGAMTGISRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVSTDVGKGLINSLPASATTPDMTALWEASLNGICHKETSYQAFMQPLLGTLSTLIQNAGAQLPTALNGLKGQGYRKTAGNKSGYRKSPYRKASSSAKRTGTASTAKTSTTTSSSAKKSSASSGTRSRTRKVAAEV
(1232) DNA topoisomerase 1 [Shewanella baltica OS155]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSEGNEKVKSAAEVKKMSPEEKAQYKKVKDQQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAELSTPAQEALRMEVVKHLDAAFNPINEQQAMAAVQALSAASFTVLAREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVENLRDMIAKEFGDKYLPAEPIRYGSKEGAQEAHEAIRPSNVHVQAATLSDMERDAQRLYELIWRQFVSCQMTPAQYDATKLTVKAGDYELKATGRTLRFDGWTRVQTALKKKNEEDNTLPFVAQGDVLALKELQPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSERLVGSFADLMSYDFTASMEQTLDDVARGELDWKKVLDGFYADFTKQLEKAELDPEEGGMRLNQMVMTDIKCPTCGRSMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGVEAISENSEDAETDALRAKHRCSICGTAMDSYLIDEKRKLHVCGNNPICEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNSECKNTRKLLKNGEAAPPKEDPIYLPDLKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVQYRELLWPKYQYLADAPVTDDEGNKAAVKFSRKTKEQYVATEVDGKATGWSAHYVNGKWVSETTKKAKKSA
(987) DNA topoisomerase 3 [Shewanella pealeana ATCC 700345]
10
MILYIAEKPSLGRAIADVLPKPLKKGDGFIRAANGDCVSWCVGHLLEQAEPDAYSPEYKSWKFEHLPIVPETWKMKPKYKMRGQIAVLRGLVKEASQLVNAGDPDREGQLLVDEIIAHLGVKGPKLQNAQRLLISDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPVLGLVVRRDAEIAEFISKPFYEVLAHLATDNQQRFSAKWQPSEACQPYMDEEGRVLSKGLAQNVVGRINGQNGTVEKVTAQDKKQNAPLPYSLSALQIDAAKRFGMSAKSVLDTCQSLYEKHKLITYPRSDSRYLPAEQHALAPSVIGAVLNGASELVSGIEQPNSKLKSKAWNDKKVEAHHAIVPTEKTANLQNLNQAEKQLYLQVARQYLMQFYPAYLYKETQVEIIIAGGLFKTKAKQEVALGWKQLLKQNKEKSQSEKQQTDDDEYLANIPALKKGQILLCERGELLEKQTQPPKHFSDATLLGAMTGISRYVTDSEIRKILKETDGLGTEATRAGIIELLFKRNYLTRQGKSILATEVGKGLINSLPLSATTPDMTALWENNLDAISRKEAKYQSFMAPLLISLQQLIEQAGAQLPTSLQGVKSPDSGFKKRRYSGNKSAATTKSATAKKASAKRVSTTKAKRATS
(740) DNA topoisomerase 1 [Shewanella pealeana ATCC 700345]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSSSDAKVVSKTAAEVKKMSPEEKAEYKSLKAKQALVARMGVDPEKGWKANYQTLPGKEKVVKELQTLAASADHIYLATDLDREGEAIAWHLQQVIGGDESRYQRVVFNEITKTAIQDAFSQPSVLDTNMVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAELNTLTDDLLKMQVVKFQGKAFSPVNEVEAQTAVSQLSQSSFVVAAREDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVRDMIGKEYGDNYLPESPIRYGSKEGAQEAHEAIRPSNVKVSAASLSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGDYELKATGRTLRFDGWTRVQTAIKKKNEEDNTLPYVAQGDAVTLKELLPKQHFTKPAPRYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVDNRRFFAEKMGEIVSDSLVGSFEDLMSYDFTASMEQTLDDVAQGKLEWKKVLDGFYKDFTKQLEVAELPPEEGGMRPNEMVITDNIKCPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTLNLTPGEEAVSSGEDAETEALRAKHRCGICGTAMDSYLIDEARKLHVCGNNPTCNGYEVEAGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNTECKNTRKLLRSGEAAPPKEDPIHLPELKCTKSDAYFVLRDGAAGIFLAASTFPKSRETRGPLVEELVKYRELLWPKYQYLADAPVADDDGNLASVRFSRKTKEQYVATDVDGKATGWTSKFVDGKWVTEAKAKPKPKAKAKPKAKPKAKATKAE
(696) DNA topoisomerase 3 [Shewanella sediminis HAW-EB3]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGHIMAANGDCVSWCIGHLLEQAEPDHYDPLFKSWKFEHLPIIPQQWKMKAKPKTRSQLTVLRGLVKKASQLVNAGDPDREGQLLVDEVIAHLGVKGEKLNNTQRLLISDLNPQAVKRALGQMRSNREFIPLSTSALARSRADWLYGMNMTRAYTLQGRKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFVSKPFFEVLANLTTDNKEAFKTKWQPSAACQPYMDEEGRVLAKGLAQNVVGRITNKPAEVTQVLAKDKKQNAPLPYSLSSLQIDAAKRFGMSAKEVLDTCQTLYERHKLITYPRSDSRYLPVEQFQQASQVVSAVSSGAAELLEGMTAPDTKIKSKAWNDKKVDAHHAIIPTEKTANLSQLGARERQIYLQVARQYLAQFYPPYLYSETEVHVLIEGGNFKTKAKQERALGWKQLFGRNSDKQKSNGPDSKNNSDDDEESSQVLPPLVKGQQLHSGMGELVEKHTQAPKHFTDATLLGAMTGISRYVTDPEIRKILKDTDGLGTEATRAGIIELLFKRSFLSRQGKSILSTEVGQGLINSLPMSATTPDMTALWESNLDAICRKEAKYLSFMSPLIASLSELITQAGSQLPSALQGVKAPANSFRKKRYSKSLGSGRKKSTTGSTSRTSATKKRASSKTQTKG
(1874) DNA topoisomerase 1 [Shewanella sediminis HAW-EB3]
9
MGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHIRDLPTSSSTEAKVATKTPAEVRKMAPEEKAIYKSIKAKQALVSRMGIDPDKGWKANYQTLPGKEKVVKELQKLAESADQIFLATDLDREGEAIAWHLQEVIGGDASRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEKESEIKAFVPEEFWDIHAQLETLNNAALKMQVVKFQDKAFNPVTESQAQTATSALSQSSFVVAARDDRATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDGVREMIAKEFGDKYLPEAPIRYGSKGGAQEAHEAIRPSDVSVQAASMKDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGEYELKATGRTLRFDGWTRVQTVVKKKNEEDNTLPVVAQGDKLNLQELMPKQHFTKPPARYGEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSESLVGSFKELMSYDFTASMEQTLDDVAQGELKWKKVLDGFYKDLTKQIEQAELAPEEGGMRPNEMVLTDNIKCPTCDRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSENSEDAETDALRAKHRCDVCGTAMDSYLIDEKRKLHVCGNNPICGGYEVEQGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNDDCKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDGYFVLRDGAAGIFMAASTFPKSRETRAPLVEELVKYRELLWPKYAYLADAPVTDDDGNKATVRFSRKTKEQYVATDVDGKASGWASKFIDGKWVSESKKKAKPKAKAKPKEKK
(1369) DNA topoisomerase 3 [Shewanella halifaxensis HAW-EB4]
10
MILYIAEKPSLGRAIADVLPKPLKKGDGFIRAANGDCVSWCVGHLLEQAEPDAYSPEYKSWKFEHLPIVPDNWKMKPKSKMRGQIAVLRGLVKEATQLVNAGDPDREGQLLVDEIIAHLGVKGAKLQNAQRLLISDLNPQAVKRALGQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGRKVGYQGVLSVGRVQTPVLGLVVRRDGEIAEFVSKPFYEVFAHLATDNQERFSAKWQPSEACLPYMDEEGRVLSKGLAQNVVGRINGQPATVEKVTAQDKKQNAPLPYSLSALQIDAAKRFGMSAKAVLDTCQSLYEKHKLITYPRSDSRYLPVDQHGLAPSVIRAVLSGASELVSSCDEPNAKLKSKAWNDKKVDAHHAIVPTEKTANLSNLSQAEKQLYLQIARQYLMQFYPAYLYKETQVEIIIAGGLFKTKAKQEVALGWKQLLKLSAKASQEKSSSEKSQTDDDEHLANIPALKKGQILLCERGELLEKNTQPPKHFTDATLLGAMTGISRYVTDSEIRKILKDTDGLGTEATRAGIIELLFKRNYLTRQGKSILATEVGKGLIYSLPQSATTPDMTALWENNLDAISRKEAKYQSFMDPLVNSLQGLIEQAGSQLPTSLQGVKSPDGGFKKRRYSGKKSTTTTKSAIANKTPAKRASTAMTKTKKATS
(984) DNA topoisomerase 1 [Shewanella halifaxensis HAW-EB4]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSSSSEAKVVSKTAAEVKKMSPEEKAEYKSLKAKQALVARMGVDPENGWKAKYQTLPGKEKVVKELQTLAASADHIYLATDLDREGEAIAWHLQQVIGGDESRYQRVVFNEITKSAIQDAFSQPSVLDTNMVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAELNTLTDDLLKMQVVKFQGKAFNPVNETQAQTAVSQLSQSSFVVAAREDRATSSKPSAPYITSTLQQAASTRLGYGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVRDMIAKEYGDKYLPESPIRYGSKEGAQEAHEAIRPSNVKVSAASLSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKAGDYELKATGRTLRFDGWTRVQTAIKKKNEEDNTLPYVAQGDAVTLKELQPKQHFTKPPARFSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSDSLVGSFQDLMSYDFTASMEQTLDDVAQGKLEWKKVLDVFYKDFTKQLEIAELPPEEGGMRPNEMVIADDIKCPTCGRPMGIRTGTTGVFLGCSGYALPPKERCKTTLNLTPGEEAISEGGEDAETEALRAKHRCGICGTAMDSYLIDEKRKLHVCGNNPTCNGYEVEAGQFKIKGYEGPIIECDRCGNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPELKCTKSDAYFVLRDGAAGIFLAASTFPKSRETRGPLVEELIKYRELLWPKYQYLADAPVADDDGNLASVRFSRKTKEQYVATDVDGKATGWSSKYIDGKWVTEAKAKAKPKAKAKPKAKAKKAE
(1636) DNA topoisomerase 1 [Teredinibacter turnerae T7901]
9
MGKSLVIVESPAKAKTINKYLGNQYIVKSSVGHIRDLPTSGSAKTTTDPKARAKQAALTRKMSAEEKEVYKQNKAREQLINRMGIDPDNDWQAHYEILPGKEKVVAELRKLADQADHIFLATDLDREGEAIAWHLQESIGGDPTRYRRVVFNEITKNAIQEAFKSPGMLDINRVNAQQARRFLDRVVGYMVSPLLWEKIARGLSAGRVQSVAVRLVSERESEIRAFIPEEYWEVKAQLDTSKGERAKYEVKRFKDEAFKPVNEAQAMAAKSALEGAAYKVTEREDKPTKSNPSAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVENCRTFIQQEYGDRYLPKAPNVYSSKEGAQEAHEAHEAIRPSDVTTRPNQLSGMERDAERLYNLIWQQFVACQMTSAEFTSSSLKVSAGDYELRARGRVIRFDGFMKVMPPVSRKEEDTLLPDVKVGDMLDLHEILASQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVHVENKRFYANKMGDIVTERLIESFSDLMDYGFTANMEAALDTVAEGDKDWLDLLNEFYADFTVKLEMAQNSAAGMRRNEPVETDIDCGNCGRKMQIRTGSTGVFLGCSGYALPPKERCKNTMNLVSGDEAVNIDEDEDAESRQLRQKRRCKICNTAMDSYLLDEQRKLHICGRNPDCDGYEVEQGVFKIKGYDGPLIECDKCGSDMQLKSGRFGKYFGCTNDECKNTRKLLRNGEAAPPKMDPVDMPELACEKVEDHYVLRDGASGLFLAASQFPKNRETRAPYIKELLPHKDEIDPKYAFLFKAPTQDDNGNDALVRYSRKTKEQYVQTEVDGKATGWKAFYDGGKWQVSGSAKPTKAAPKAKATRKKKS
(1588) DNA topoisomerase 3 [Pseudoalteromonas atlantica T6c]
10
MILYIAEKPSLGRAIAQGFSGQQQKHDGYITLGNGDCVTWCIGHLLEQAEPDKYDPAYAKWALQHLPIVPQDWILVPKKGTSKQLSVIKRLLKTASQVVNAGDPDREGQLLVDEVITYCKVKRDIIDNAGRLLINDLNLNAVKKSLTNIRPNREFTGLSISALARSRADWLYGLNLTRAYTLLGQRGGYSGVLSVGRVQTPVLGLVVRRDAEIAQFKSKPFYEVMATLATQTEQPSQTFTAKWQPSSACEPYQDEEGRVIVKKLAETVVNKTRGQPGVVESYTVKDKQSPPPLPYNLSALQIDASKRFNLSPKAVLTVCQSLYERHQLITYPRSDSRYLPMEHFSEATKVLSAIKANAPEQQSAVENANSKLKSKAWNDSKVDAHHAIIPTSRNKAISSLSGDEAKIYQLIATQYIMQFYGPHKYQEQVAVVTIAGGTFVAKAKATTDKGWLVLTKQNGVAIPENGQTKNEPALPTLVKGQALDCVDSQLVEKQTSPPKHFTEATLLAAMTGIARYVQDANIKKILKDTDGLGTEATRASIIDLLFKRQFMQKSGKEIHATPTGKALIYALPSESTQPDMTAIWEANLDKISQRKMRYQDFMQPLTHTIGELINASQRIDTSQFAGLASTKPAYKKKWRKKKKAS
(634) DNA topoisomerase 1 [Pseudoalteromonas atlantica T6c]
9
MAKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGKVPPKKPAKELKLLSEKKRESYLREHEYRKLVDRMGVDPKNDWEAHYEVLNGKEKVVNELKKLAKNADTIYLATDLDREGEAIAWHLQELIDDPSKDYQRVVFNEITKNAIQEAFSEPGKVNVERVNAQQARRFLDRIVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDVHADLVTAKQSDLRMQVAKYNDKAFKPVNKAQTDAALSDLEGADYKVVSRDSKPTQSRPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSKEAVDACRDYIGDNFGDKYLPENALKYGSKEGAQEAHEAIRPSNVLLKSESLSEMERDAQRLYELIWRQFVACQMTPAKYDASTIRVSANGYELTAKGRVLKFDGWTKVQNPQRKKGEEDFLLPDVKEGESLNLKQLDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLESKRFYAEKMGEIVNDRLLENFDNLLSFDFTAKMEQELDEIANGKVSWKDVLNDFYGDFEQKLHLAEKDPEDGGMRLNQAVPTDIACPKCGRPMNVRTASTGVFLGCSGYNLPPKERCTGTMNLTSGDEVIKVDDEEELETELLRAKRRCPICATAMDSYLVDETRKLHVCGNTPTCPGIEVEEGTFKIKGYDGPIIECDKCGSNMELKNGRFGKYFGCTNEECKNTRKLLRNGEAAPPKEDPVDLPELECTKSDAHFVLRDGASGIFMAAHNFPKSRETRAPLVAELARFRDRISPKFYYLADAPAKDPDGNDTLVRYSRKTKQQYVMSENEEGKATGWSAWYTDNKWTVEDKRKKAK
(681) DNA topoisomerase [Pseudoalteromonas haloplanktis TAC125]
10
MLPKPHKKSDGFITAGNGDVVTWCIGHLLEQAEPEAYNPDYKKWAVEHLPIVPNEWKLVVKSKTRKQFTVVKTLIKKADTLVNMGDPDRVGQILIDEVINHCGVSKAKKTQVLRCLISDLNPAAVKKALNNLRKNTDFIPLATSALARARADWLYGINMTRLCTLQGRQSGYNGVLSIGRVQTPVLGLIVHRDLEIANFVSKPFYEVICTLLTSKGEAYQAKWRPSKACEPYMDEDNRVLSKPLALNVISKVQNKAGKVVNVTQAKKATPPPLPYSLSALQIDAAKRFGMSAQSVLDTCQQLYERHKLITYPRSDCRYLPKEHLNDVKQVVGAIGKSCSALSDAANNANLSLKNKAWNDSKVSAHHAIIPTSKSTDLSRLSPAENNIYELVARQYLIQFYPPFEYVDKQIDTEVSGGLFISKQKDVVSQGWKALFPSKQKSQAESEFSAVSLPNVSKGDEVHCQQADLIEKQTTPPKYFTDATLLSAMTGIARYVTDASIKKVLRDTDGLGTEATRAGIIELLFKRQFLTRKGKDIRATDVGTQLICSLPERMTIPDMTAHWESQLEAISQKEIKYAHFMDPITQSIDTLIAEVKTVTFNGLKGKGTPYKSKKYFKTKTKVNKKNVERL
(1089) DNA topoisomerase 1 [Pseudoalteromonas haloplanktis TAC125]
9
MGKSLVIVESPAKAKTINKYLGNDFIVKSSIGHVRDLPTSGSGKNKVPATKTPAEVRKLPPEEKAAYKKQRDYSNLVARMGIDPDKGWEPHYEILPGKEKVVQELKKLAENADQIYLATDLDREGEAIAWHLQEIIGGEPAKYKRVVFNEITKNAIQQAFETPGELNTDMVYAQQTRRFLDRVVGFMVSPLLWAKVARGLSAGRVQSVAVRLLVEREREIKAFIPEEFWDIHADVKNAESELRLEVAKQADKPFKPVNEAQASAAVKSLENAEYKVISVDEKPSKSRPSAPLITSTMQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKDAVAMCREYVTEQFGEKYLPKDPINYSSKGNAQEAHEAIRPSSVTVLSGHIEGVDADAKKLYELIWRQFVACQMVPAEYDLTTLTVAANDFQLKAKGRVLRFDGWTKVQPAIRKKNEEDQSLPAVTVGETLTLIELDPKQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFFAEKMGEIVTDRLVENFEDLMNFDFTAKMEGRLDDIAEGERIWTEVLDKFYADFSTQLTVAKDEPENGGMRLNEMVETDIECPTCSRKMGIRTASTGVFLGCTGYNLPPKERCTTTMNLVSGDEAVAADSADAEDLETETLMQMKRCPICETAMDSYLIDETRKLHVCGNNPACSGHVVEQGTFKIKGYDGPLIECDKCGADMELKSGRFGKYFGCNNDECKNTRKLLKNGEAAPPKEDPVHITELECEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPKVEELQRFRDRISPKFYYLADAPAQDPDGNLAVVRYSRKNKEQYVMTEVDGKATGWTAHYVAGKWVEEAKKKAAPKKKAAAKKAPAKTKAKAKTKKDDE
(1853) DNA topoisomerase [Colwellia psychrerythraea 34H]
7
MKLYIAEKPSLGRAIAAALPKPQKNHKTHIELANGDVVSWCIGHILAQADPEDYDAELKKWRMESLPIVPQQWQLKPIARTRSQLTVLRKLVKQADEIIHAGDPDREGQLLVDEVIDYFKLSKTKKANIKRLLISDLNLPAVKRALTSLKPNSDFMPLSISALARSRADWLYGINLTRAYTLQGQKTGYNSVLSVGRVQTPLLGLVVRREQEISEFVSKPFFQVQAHIALSSKDAVAFTAKWQPSENCQPYCDEEGRVLVKALAENVVKRIANQPATISNIDSNEKQQAAPLPFNLSQLQISAAKQFSMNAKLVLDVCQALYERHKLITYPRSDCRYLPKEQLKQASGIVNTLANSSLPCNKPAQGANTSFVSKAWNDKKITAHHAIIPTEKSPENINLNTFEKNVYLLIVRQYLVQFYPAYIFQQTKVELLIAGGNFMSQAKTEKQLGWQVLFPKSNKTNNQSKLEHGQEQEQTLPPLTKGQLLHCQQGELIEKHTSPPQSFTDATLLGAMTGISRYVNDAAIKKVLKETDGLGTDATRAGIIDLLFKRGFLQRQGKAITATKVGVALITALPTMATLPDMTAQWEATLTAISEKNANYLSFMQPLTVIVNEMVQGASQQSFSGLPKVAFKPKRGKRTFQKKAVKKAS
(1179) DNA topoisomerase 1 [Colwellia psychrerythraea 34H]
9
MAKSLVIVESPAKAKTINKYLGNDFIVKSSVGHVRDLPHSSTGKKVAAKSPAEVRKMEPAAKAKYKAKRDKQALVNRMGIDPDKNWAADYQILPGKEKVVAELKKLADKADIVYLATDLDREGEAIAWHLKEIIGGEDEKFRRVVFNEITESSIQQAFATPGELSMPGVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEKEREIKAFDPKEFWEIAVDTHASTGEVLTLDVTHENGKAFKPTTEKETNAALAILKPADYAVSKREDRPSKSTPSAPFITSTLQQAASTKLGYGVKRTMGLAQRLYEAGHITYMRTDSTNLSKDAVEMCRKYISDSFGDNYLPENAKTYGSKAGAQEAHEAIRPSNVKLEAAFLEGIEADAKKLYELIWRQFVACQMTAARYTVSTLTISAASFDLKAKGRVMQFDGWTIVHPQLSKGDDTHLPDLQVGEALTLDKIEPSQHFTKPPARFGEASLVKELEKRSIGRPSTYASIISTIQDRGYVRLDKKRFYAEKMGEIVTNSLSGSFEKLMSYEFTSNMEQELDEIAGGSADWKGVLDEFYKNFTKQLSKADQPSEDGGMQTNEPVLTDIDCPTCNRKMGIRTAQTGVFLGCSGYALPPKERCTKTMNLTAGEEAVSILAEDAETEALMAMRRCDKCGTAMDSYLIDETRKLHVCGNNPVCDGIEVEKGEFKIKGYDGPILDCDRCESPMELKSGRFGKYFDCTNEECKNTRKLLASGEAAPPKEDPVQLPELECEKSEAHFVLRDGAAGIFLAAHTFPRSRETRAPKVAELQRFRDRISEKFYYLADAPAEDNEGNLSVVRYSRKTKEQYVMTEIATEEGKPKATGWTAKYIDGKWIEDIPKKKVAKKKAAKKPAAKKKAKTAAE
(84) DNA topoisomerase 3 [Psychromonas ingrahamii 37]
7
MKLYIAEKPSLARAIADALPKPHRKADGCIYVGNGDVVSWCIGHLLTQVDPEAYDPEYKKWKFEHLPIIPENWKLKSTPRTSKQLSILKKLIKQADNLVHVGDPDREGQLLVDEVIHFSGVKGNKLKQVERCLVSDLTTNAVKRSLQQLRSNQEFIALSTSALARTRADWLYGLNLTRVYTLQAQKSGYQGVISVGRVQTPLLGLVARRDKEIEVFVSKPFYEVEAHLTTLKPENVAAFTAKWKPSEACEKYQDHEGRVLVKKLAENVAQRISQQHAVVKSFTAKNKKQVAPLPYNLSALQIDAAKRFSYTALEVLDICQALYEKYKLITYPRSDSRYLPKNHLSQAGSVTRAIANNQPALKKAVSNADISLQSRAWNDKKVDAHHAIIPTDKHQSLTSLDTASQNIYALIARQYLCQFYADYHYGECVAEIEINNGLFISKAKAKISDGWKVLFDKQEKDSYLPALSKGQKLFCDKGEVIEKNTQPPAYFTDATLLAAMSNIARYVKDGELKAVLKETDGLGTEATRAGIIELLFKRLFLQRTGKLIKATETGRKLIESLPEMLTLPDMTAQWEMELNAISQKEQSYQGFVVPLQNQLKSIIEKAIADGPRALANLPSSGNVFKKTYRKKSTKKGTFKKKGS
(1563) DNA topoisomerase 1 [Psychromonas ingrahamii 37]
9
MSKFLVIVESPAKAKTINKYLGKDFIVKSSVGHIRDLPTSGSAKKKIEAKGTKSLAGMTPAKKEKEKAKRTQSALVARMGVDPNDHWKANYEILPGKEKVVAELQKLAVDAPIIYLATDLDREGEAIAWHLREVLGGEHQKYKRVVFNEITETAIQEAFEHPTELNIDGVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERERLIKVFNPVEFWDLHADVQDKTKSDLRLEVFKENGKFFKPVTETETLKAVDHLKSAEYKVLSREDKPTTSKPSAPFITSTLQQAASTRLSFGVKKTMMLAQRLYEAGYITYMRTDSTNLSKEAVGSARDFISDEFGKNYLPAEPVVYSSKSGAQEAHEAIRPSDVGQLAALLVGVDRDAQRLYELIWRQFLACQMLPALYDATTLVVQAGDYQLRAKGRTLRFAGWTKVQPVAKTQVDEVQFPELAIGEVLELVELDPKQHFTKPPARFTEAALVKELEKQGIGRPSTYASIISTIQDRGYVKVDKRRFYAVKMGEIVSDRLSENFVELMSYDFTAQMERNLDAIAEGKANWTEQLDDFYQDLTTLLEKAERDPEEGGMRLNEPVIIKEIHCPTCDREMGIRTASTGVFLGCSGYALPPKERCKTTINLVDGEEVVDLLSSEDLETAALMAKQRCPKCDMAMDSYLVDEKRKLHVCGNNPLCDGHLVEYGEFKIKGYDGPVVECDKCGSDMQLKDGRFGKYMGCTNEECKNTRKILRSGEVAPPKEDPVDLPELECEQSDAHFILRDGASGIFLAANTFPRSRETRAPKVAELARFKDRISPKFYYLAEAPQKDPEGNLAVVRYSRKNKEQYVMTEIDKKATGWTAKYIDGKWVEEQTKKRAVKAKK
(1068) DNA topoisomerase 1 [Idiomarina loihiensis L2TR]
9
MAKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTRATETIKSKPAAEVRKMSPDAKAKYQKERDYKRLIARMGVDPENDWEAHYEVLQGKEKVVKELKQLAKKSDEIILATDLDREGEAIAWHLRELIGGDDSRYKRVVFNEITKKAIQEAFQHPAELNTDRVNAQQTRRFLDRVVGFMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWDVHADLNTPADESLRMQVMKQAGKNFRPSNKQETDAALALLKKAGYEITGREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSSEAVDACRELITKDFGKNYLPDDPVRYGAKSNAQEAHEAIRPSDVKVKSESLASVERDAQRLYELIWRQFVACQMVPARYDSTTLTATAGDFELKARGRVMRFAGWTKVMPPASSKKDGDATLPDVKKGDALQLEKLNPEQHFTKPPARYGEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFFAEKMGEIVNDRLIENFTELMNYNFTAEMEQALDDIAAGKRDWKETLDKFYADFKERLEKAELEPTEGGMRENSMVLTDIDCPECGRKMGIRTASTGVFLGCSGYNLPPKERCTKTLNLTPGEEAIEVTDEEERETEALRAKKRCPKCGTAMDSYLIDEKRKLHVCGNNPTCDGQLVEEGTFRIKGYDGPTIECDKCGSEMQLKTGRFGKYFGCTNSECKNTRKLLRSGEAAPPKEDPVPLPELPCEESDAYFVLRDGASGIFLSANTFPKSRETRAVTVKELAKFKDRLPEKFKYLAEAPKEDDDGNDAIVRFSRKNKEQYVVTEIKKKQTGWKAFYRSGKWQVEEK
(1124) DNA topoisomerase 1 [Acidithiobacillus ferrooxidans ATCC 23270]
1
MTKLLIVESPTKAHHIQAMLGSGWSVKATVGHIRDLPIKGDAAYVRPPDFKLNYEITERASKTVPALRAAARDAESVYIATDPDREGEAIAWHVCQVLGIKPGAAKRVTYQEVTEPAIRKAIAAPRTVNMPLVAAQEARRALDRIVGWEVSGPLSNAIGSRASAGRVQTPALSLVVAREQAIRQFKPTPWFQVLAHVAGKDAAPDWRAVWVDGTQEGEYFQDKAHAKALADALPSMALKVTKAETKPVRKPPAPPFTTSSMQMDGARALKAPVDAIMKAAQSLFEHGHITYHRTDSPNLSEEGEGLLRAALKKENLPLVETPRRWRSKGGAQEAHEAIRPTRPMVRQAGENDLEQALYDLIRKRALASQMPDAVYQQTSCTLDGGMFQGRPAVFRAVGSVLKDPGWMALYRETAEDEEGTENPAANPVPRLAVGDAVRAARGECLSKTTKAPPRYTESTLIKALEDHGVGRPSTYASILKNLFAREYIRRKGKSPALYATELGEKIVEALSVFDFSNVDYTREVEADLDRITEGQMRPRDLLAKSFADIQRILDAMPTQARAQGRPCPIEGCDGTVRRLESKRKPGVFFWMCSNRDAHPLLQDNDGEPGAPFAERVEAGDGPACPECGAATSRQETGKGYGYFRCGKGHGSWWDDKGSLGKKWEDRAPAQGAASGPARKNTGSKASSTKRPTKGTRTKARSSIMD
(228) DNA topoisomerase III [Acidithiobacillus ferrooxidans ATCC 23270]
7
MKLYIAEKPSLGKGIAEYLPGSKNKGNGFIQCGVDTVVTWCFGHIFEQEEPDFYTPDDVPTTPKGKKKWRFEELPIFPEQWKKRAKDDAKAQIKVIRALLKKASSVVNAGDPDREGQLLVDEVLEELRWKGPTLRIWLAALDEQSVRKALASLKDNHDYQNLRNSAEARARADWLMGMNLTRAFTLRNSGAGVVSVGRVQTPTLALVVARDEKIEHFKPKDYYVPRINAGFWATWELREDFEGVDAEGYLTDRKAADRLASRAKAEGKATVKDFTSAEKQQQAPLGFSLAELQKVCSAKLGMSAQSVLDAAQALYEEHKAATYPRTDCRYLPEEQHGDAGQILSGLAKAGFADLVKAADSNRKSAIWNTGKVTAHHAIIPTGSMQGSMSPAVAKVYDIIVRSYLAQFYPPYVYRAIKALLTCTSEDWKATANIPVSAGWKAVYGMTDDDNDDTPAQPIPALKKGQVLTVQDADVQAKQTKPPARFTDGSLIEAMSNIHKVVEDEAAKAKLKETSGLGTEATRASIIETLLTRGFLERKGKQILSTQAGRALVHALPKDLTDPVLTARWEDALSSVSEGRVTLQQFEEAQRKFVVRMIEAAKATTVAVGQARPTSGAGRGKSSTGKTRGVGQKTGPACPDCKKLTITLKTKKGDAFFKCEGCQSCWWPDKQDAKKLGTKWGLEKNEYVRREDWISHTQQD
(782) DNA topoisomerase 1 [Acidithiobacillus ferrooxidans ATCC 23270]
1
MAHQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDLQPKEGAVDTEHDFAMRYTPIERNERHVDAIAKALRGADKLWLATDPDREGEAISWHLVELLRERQLLGDKPTQRVVFHEITKKAVQEAIAHPREIAMDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASRLQHAGSAFTGRLTHWQNKKLEQFDIADGDQAQAIRSGMEDDLGRQALRVREVERKSRQRQPAAPFTTSTLQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRTFIDGYYGSEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPESLQGVLERDLWRLYDLVWKRSIACQMAPARLDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDESNRILPPLDVGDEPLVLGIDPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQRRFHPTDLGRVVGRFLINHFERYVDYGFTASMEDELDAVSRGEKQWQPVLSAFWSPFRALLDEKANVSRAEATSEALEEACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAEPVGRDCPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQPKSSGVTCPQCGEGELVEKRSRYGKVFYSCNTYPKCTYAVWGPPVARPCPRCGWPIMIEKSGKRLGEQLACPQSECAFHFPANASDAEIAALLPGYSPPPPREKRAPPAKKAAPARKTTAKTAKKPATEATAVAAQKTAKAKTTSAAAKKPAASKARGPSAGEGKTSPSRKRAAKGASDS
(1438) DNA topoisomerase [Acidithiobacillus ferrivorans SS3]
7
MKLIIAEKPSLAKAIREVVGKEYTVTNAFGHILEQAGPDEYTPAEVPVNPKTSKKRWRLEDLPIFPQTWIKHPKPDAKEQLMKIKGMLKEAALVVNAGDPDREGQLLIDEILEYCGYRGPVQRVWLASLDETSVKKAFANLRDNKEYRTLSQAAEARSQADWVVGMNLTRAWTIKNNGLLSVGRVQTPTLALVVRRDLEIEQFKPRDFFEVIAHCRHQNGEFVVKWRPAVNDGPGFDEEGRLVGRQLADSIAAKAAGHGKIARYDAKDSKQSAPLPFSLSALQKAASAKFGMSANQVLETAQSLYEMKITSYPRSDARYLPEEQYSDAGRILSHLPIPDPLKAKVLANRKHAAWNTGKVTAHHAIIPTGDRAAGLTDAEQKIYDLIWKSYVALFLPDYLYKAISVAVDLGGEQWTTSGRLDMDMGWKALYGASAADDDEDGDGEGKAKLPSMTTGDAIAGQKGEVQAKQTKPPARFTDGTMIEAMSNIHKFVTDATAKAKLKETSGIGTEATRANHLSSIADGKLDPNKFMGAIQQMVREQLGKVTAGVSVSGGKSGGGSGGTKKVGPQCPDCKAATIILKTKTGKPFVKCEKCGSAWWPDRNDPKKLGSKWEARK
(126) DNA topoisomerase 1 [Acidithiobacillus ferrivorans SS3]
3
MSALLIVESPKKAQHIGHILGNGWQVKATLGHIRDLPVTGEAAYVRPPDFAMRYEILDTKHKEIVSGLRAAAQSADAVYIATDPDREGEGIAWHVCQVLKIKPGEAKRVSYQEVTETAIRKALLAPRPVNMRLVAAQEARRALDRMVGWEVSPVLSNSIGAKASAGRVQSPALALVVERERAIKSFKPTAFYQVLAHMPGKDGVSGWRASWIDGTKEGEYFQDKAFAQALADALPSMPLVVSKAESKPVRRAPAPPFTTSSMQMDGARALKVGVEDIMKAAQALFDNGHITYHRTDSPNLSEEGEGLLRAALEKTGLPVVDKPRRWKAKGDAQEAHEAVRPTKPMLEEAGEDANQRALYQLIRKRALASQMPDAIYQQTSCTLNGGTFHWRDLSHPALFRAVGSVLTDPGWRALYTESEDEGEGKETEAANPVPKLSVGDKLKAERGEMVSKKTKAPPRYTESTLIKALEDHGVGRPSTYASIIKVLYKRDYMKRKGKAPALYATDLGEQVVDALRPFDFAGLEYTRLIEESLDLITEGKMPPRDLLAKSYADIQSTIATMPKGADNSQPCPVDGCGGTVSRRESKKKKGSFFWACSNRDNHNLLQDKDGTPGEPFGDKVESNTDGPACPECGKPTGRYETSNRHGFFRCAKGHGTWWDDKGAIGKLWETLPAGKGGKAKPEAAAKKSAGKPARKRTGKPAARRSTIMD
(687) DNA topoisomerase 1 [Acidithiobacillus ferrivorans SS3]
1
MAYQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDLQPKEGAVDTEHDFAMRYAAIERNERHVDAITKALRGAEKLWLATDPDREGEAISWHLVELLRERHLLGNMPTQRVVFHEITKKAVQEAIANPREIAMDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASHLQQAGSDFSARLTHWQDKKLEQFDVTESDQAAAIRSGMEDDLSRQPLRVREVERKSRQRQPAAPFTTSTLQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRDFIGGHYGGEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPEALQGVLERDLWRLYDLIWKRSIACQMAPARMDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDEGNRILPPLNTGDEPQVLDINPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQRRFRPTDLGRVVGRFLTNHFERYVDYGFTASMEDELDAISRGEKQWQPVLSAFWGPFRALLDEKANVSRTEATSEALDEACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAEPVGRDCPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQPKSSGVTCPECGEGELVEKRSRYGKIFYSCNTYPKCNYALWGPPVARACPRCAWPIMIEKSGKRLGEQLACPQSECAFHFPANASDTEIAAMLSDYTPPPPREKRAPPAKKAAPARKAAAKSTRKPAVKAATAANKPAKAETTAAVVKKPSKAKTPAAKKSTSSKNTTSSASEAATPAARKRSVKNVTNS
(981) DNA topoisomerase 1 [Legionella longbeachae NSW150]
1
MSKHLVVVESPAKAKTIQKYLGNDYEVIASYGHVRDLPARKGSVNPDKQFAMTYVPIEKNARHIETIAKILKKSDSLLLATDPDREGEAISWHIYELMKEKNLTKDKTVHRIFFNEITKSAIQDAINHPRTISMDLVNAQQARRALDYLVGFNLSPLLWKKVRRGLSAGRVQSPALRLIVEREEEIESFVAQEYWKILAQCFHANSPFEARLTHYKNEKIQQFTIVNQEQAQQIKEFLIDQAKGSLFVTNIEKKQRKRKPSPPFITSTLQQEAARKLGFTARKTMMVAQQLYEGIDIGTGTVGLISYMRTDSVNLSVEAIEEIRQFITERFGAANCPTSPRAYKTKSKNAQEAHEAIRPTSIKRVPEMVQSSLTTDQYKLYNLIWKRTIACQMADAVLDTVAVDLTCGEGTIFRANGSTVTFPGFLSVYEEGRDDAKDDENDGSLLPVLVVGEKVNVQDILANQHFTEPPPRYSEATLVKALEEYDIGRPSTYATIIHTLQQREYVVVDKKRFFPTDVGRIVNRFLTGYFTRYVDYKFTAELEDTLDAVSRGEKEWIPVLDEFWKPFVQQIKTTDEQVQRKDVTSEVLDEKCPKCEKPLSIRLGKRGRFIGCTGYPECDYTQDIAGQENEKKEPEVIEGRVCPECSSPLHIKVGRYGRFIGCSNYPQCKHMEPIEKPADTGVDCPKCHQAKILQRKSRKGKIFYSCGNYPKCDYALWNEPINQPCPKCNWPILTVKESKKFGRQILCPQEGCGHSTKEE
(1371) DNA topoisomerase 1 [Coxiella burnetii RSA 493]
1
MVKSLVVVESPAKAKTIEKYLGKDFKVMASYGHVRDLIPKEGAVDPEDHFKMHYQAIERNIRHMDAIAKALKPCHNLYLATDPDREGEAIAWHVKQMLESRNGLKDKKFSRVVFHQITKKAVQHAIENPRDISMDLVNAQQARRALDYLVGFNLSPLLWKKIRPGLSAGRVQSPALRLIVEREIEIENFESQEYWTIHADCHAQQQPFDARLIEFQGEKLEQFSIVNEKQAHETRDAITQAANGKLTVAKVVKRERKRNPAPPFITSTMQQEAARKLGFSASKTMQIAQQLYEGVNLGEEGAMGLITYMRTDSVTLASEALQEIRQLIEEKYGQENVPEQTRIYKTKSKNAQEAHEAIRPTSAFRTPENLKKYLNSDQLKLYTLIWKRTIACQMIEATLHTVAVDLKAPNAIFRANGSTIVKPGFISVYQETFDDKKKEEESDSKMLPPLEEGQTVDVNEIKSEQHFTEPPPRYTEASLVKALEEYDIGRPSTYASIIATLKNRKYVDVDNKRFIATDVGRIVNRFLTHYFTKYVDYGFTAKLEDELDDIARGEKTWIPVLETFWSPFKNLVDVTEKTVKRSDVTQEKIDEKCPKCSAQLSIRLGRRGRFIGCTAYPDCDYTRNLTEIAAEAQAVLEGRQCPECQSNLIIKMGRYGKFIGCSGYPNCKYMEPLEKPKDTNVTCPKCKKGTILQRKSRRGKIFYSCARYPDCDYALWNEPVAEACPKCGWPILSIKTTKSRGTEKVCPQKSCNFIEAYDGDKPSLD
(448) DNA topoisomerase 1 [Alteromonas sp. SN2]
9
MAKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTKALGKVEPKKPAKELKTYSEEDKQEYLRRHEYLKLVDRMGVDPEQNWKAHYQVLQGKEKVVNELKRLAKDADTIYLATDLDREGEAIAWHLQELLGSKGKTYQRVVFNEITKNAIQEAFSDPGEVNVARVNAQQARRFLDRVVGFMVSPLLWKKIARGLSAGRVQSVAVRLVVDREREIKAFVPEEFWDIHADLTSEQKAALRMLVAKHEGKAFKPVNKAQADKALEDLNGAKYLVESRESKPTSSRPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQEALDNCRAYIDDNFGSQYLPESPNRYGSKEGAQEAHEAIRPSSVKVNAAHLGDMERDAQRLYELIWRQFVACQMTPAKYDATTIRVGAGNYELTAKGRVLKFDGWTRVQPQLRKKGEEELMLPDVQKGDVLNLNALDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLENKRFYAEKMGEIVNDRLMENFDDLMSFDFTANMEQQLDDIAEGNKDWKDVLNLFYSDFYGKLLNAEKAPEEGGMRLNQAIPAGITCDKCGREMNVRTASTGVFLGCSGYNLPPKERCTNTMNLTPGDEVVKVDDEEELETEALRAKKRCPICSTAMDSYLVDETRKLHVCGNTPTCEGTLVETGTFKIKGYDGPIIECDKCGSDMELKNGRFGKYFGCTNEECKNTRKLLRNGEAAPPKEDPVDLPELPCEKSDAHFVLRDGASGIFMAAHNFPKSRETRAPKVEELARFRDRISEKFYYLADAPQKDPEGNLAIVRYSRKTKQQYVMSENEAGKATGWSAWYNDGKWETQAASKPAAKTKAKAKKK
(51) DNA topoisomerase 1 [Stenotrophomonas maltophilia R551-3]
1
MPKHLLIVESPAKAKTINKYLGKDYTVLASYGHVRDLIPKEGAVDPDNGFAMHYDVIDKNEKHVDAIAKAAKSADDILLATDPDREGEAISWHIAEILKERGLVKDKPMQRVVFTEITPRAIKEAISQPRAIASDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIAAECAHPSQHFNAKLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGALHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVAIGDEGTVGLISYMRTDSVNLSQDALAEIRDVIARDYGIASLPDQPNTYQTKSKNAQEAHEAVRPTSALRTPAQVSRYLTDDERKLYELIWKRAVACQMIPATLNTVSVDLSAGSDHVFRASGTTVVVPGFLAVYEEGKDNKSAEDEDEGRKLPAMKPGDRIPLERIVADQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVEMEGRSFRPSDVGRAVSKFLSSHFTRYVDYDFTAKLEDELDAVSRGEEEWIPLMSRFWEPFKELVEDKKESVDRAEASGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEEKPKFASLRPGQSMHTITLEDALELFLMPRALGEDKGEDVSVGIGRFGPFAKRGSTYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKEFEGSDIQVLNGRFGPYISDGRMNGKIPKDREPASLTLAEVQQLMEETGKPVRKGFGKKAAAKKAPAKKAAVKKEAAPKKAAAKKAPAKKTVKKAAAKKAPAKKAVKKAAK
(941) DNA topoisomerase [Marinobacter aquaeolei VT8]
7
MHLYIAEKPSLARAIAAALPGPHEKGQGWIRCGKGPDAATVSWCIGHLLEPAEPARYNPAWKKWRIEDLPMFPEPWQLTPKDSVRLQFKVLEALVRKADLITHAGDPDREGQLLVDEVLRYLGTKAPVKRILINDLTPKAVARAIQNPRDNREFRPLSHSALARQRADWLYGINLTRFYTLSYQTRGEQGVFSVGRVQTPVLGLVVDRDNTIEHFQPKPWYRVEATFQASEPEADQRPFIARWLPGDEFQDHLDEENRLLDKSVAEQIVAAISGRPGRIDEARFRDRPEPPPLPLSLSALQIEAGRLYRMGAKDVLDTAQNLYERHQLITYPRSDSRYLPEEHFSQREAVIRAIARVAPDLSGFCEKTGTERRSAAWNDQKVDAHHAIIPTVRPAPNGKLSSAEQKIYDLISRFYLMQFAPDAVHREGRLTVAIQDYRFRATETAVIEPGWKTLEIRKREPGQEPEKAPLPRLEKNEPVLCTDPQTNERKTQPPQHFTDATLLSAMTNIARFVADNELRKTLRETDGLGTEATRAAIIDTLFRRDYLFREKRFIRATDKGKSLIAALPESIRTPDRTAVWEATLEGVRRGEEDPRAFLESLKDEIRGFMAQAPAAGLANTETPGTAIHCPKCRAPMVEREGKFGAFFACTRYPACKGTRPLEDHQPEDGTSQKPVPCPHCFSPLVRRKSNKGWFWGCSNFPGCRQTVDDHNGRPAVDLRNST
(135) DNA topoisomerase 1 [Marinobacter aquaeolei VT8]
9
MGKSLVIVESPAKAKTINKYLGSDFIVKSSVGHIRDLPVSGSGSQSDPKERAKQAAATRKMSPDEKAEHKKRKAREQLVARMGVDPDHDWSARYEILPGKEKVVSELKRLAKSADHIYLATDLDREGEAIAWHLQETIGGEPDKYRRVVFNEITKRAIQEAFKDPGNLDNNRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVRLIVEREREIRKFVPEEFWQLHADLAAEGAKDPVRFEVTRYIDKPYRPVNEAQSKEHVERLKAGGFKVAKREDKPTRSRPSAPFITSTLQQAASNRMGFSVKKTMMLAQRLYEAGFITYMRTDSTNLSQDAVVSCREFVQKQFGERYLPEKPRVYGSKEGAQEAHEAIRPTDVARRPTDITGLEKDAEKLYDLIWRQFIACQMADAEFLSTSIVVANGDYELRTRGRIVKFDGFLKAAPQSTKKDEDVALPDIKVDQPLDLKKLDPTQHFTKPAPRYTEASLVKELEKQGIGRPSTYASIISTIQDRGYVKLQNRRFYAEKMGEIVTERLAESFPNLMDYDFTARLEDELDEIAEGEVQWKKVLNDFYAKFRNQLESAEKTDGGMRANTPTETDIPCPSCGRNMQIRVASTGVFLGCSGYSLPPKERCKTTINLVSGDEVVSADDDVEGEGETRLLRKKRRCPKCGTAMDSYLIDEKRKLHVCGNNPDCSGYEVEEGTFRIKGYDGPTLECDKCGSEMQLKTGRFGKYFGCTNSECKNTRKLLKNGEPAPPKMDPVPMPELKCDKVDDTYVLRDGASGLFLAASKFPKNRETRPPLVMEIKPHRKEIDPKYDYLMDAPEKDPEGNPTVIRYSRKSKEQYVMSEKDGKATGWSAWFENGRWVPRDKKK
(1322) DNA topoisomerase [Haemophilus ducreyi 35000HP]
4
MRLFLCEKPSQGNDIAKVLGATKRGDGCLSSGNGQVFVTWGIGHLVEQLNPEQYHPEWKKWSLETLPIIPGQWQLAPKKETKKQYNIVIKLIKQASEVIIATDIDREGETIARELLELAGFKGKIQRLWLSALDDASIRKALALLKPNHETLPLYYAGLGRSRADWLIGMNFSRLFTLLAQQQGYQGKPLSVGRVQSPTLALVVNRDREIQNFVPKNHFTLSALLYSGQQNFTAQYVIPEQYCDEDGLCLSQQTIQAVNQQVQQAGVMKVESVETKREKQSAPLLFALSDLQSEANRLYGLGAQQVLDIAQSLYETHKATTYPRTDCGYLPESQLAEAPQVIKSLISSDSRLQPLTSKLNLTQKSRAWNDKKITAHHGIIPTAVKVDIGKMSEEEFRLYDLIRRRYLAQFLPVSQSDKTQIVLKCGVHTFISRGNVLIATGWKMLCGAPMTKRNGKNGQFWGCTAYPDCQHIENIGKSTARRKGTANSQNISQQIANLRKLVQ
(1513) DNA topoisomerase 3 [Haemophilus ducreyi 35000HP]
10
MMRVFLAEKPSLARAIAEVLPKPHIRGDGYIQCGEHDYVTWCIGHLLEQAEPDAYDERFKTWRMEHLPIIPQQWKLIAKKQTAKQLKVVEKLVKKAEILVNAGDPDREGQLLVDEVFNYLNVPASKKSQIQRCLVSDLNPTAVSKAINKLQNNCDFIPLATSALARARADWLYGINMTRAYTLQGRWVGYQGVLSVGRVQTPVLGLIVRRDLEIEHFTPKDYFEVLAHIIVPTTQERFTAHWQPSKACEDYQDEEGRVLSRALVENVVKRISDQTACVTDYQDKTESEIAPLPYSLSALQIDAARRYGLSAQAVLDICQTLYETHKLITYPRSDNRYLPNEHYNERFNVVAAIAHHLTEYQQKPEVVNLALRGRCWNDKKIEAHHAIIPTARQGNLRLTENEKRIYRLIACQYLMQFCPDAEYSKRKITLDIAGGTFIAQARNLVTAGWKALLGKEDCDEMIEPLLPAVQKAQRLHCEKREIISKKTQLPRHFTDASLLSAMTGIARFVQDKQLKKILRETDGLGTEATRAGIIELLFKRGFVTKKGRNIQSTETGRVLISALPDIATQPDMTAQWEMQLKQISQKQVSYQQFMHQLTTKLPELLHTDRQKLQKLNIITPLKLPAKRTHTKASIMADEK
(444) DNA topoisomerase 1 [Haemophilus ducreyi 35000HP]
9
MGKSLVIVESPAKAKTINKYLGSDYIVKSSVGHIRDLPKSGSEKAEKVKPISTKGLTAEQKAKVKADKARAALVKRMGIDPYHDWKANYQILPDKDKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGKEEHFSRVVFNEITKNAIQKAFEKPEQLNLDRVNAQQTRRFLDRIVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWDILANTLAENGRLPLALTSYKGKKFVAKNQTEADNAVKALQCCEFVVSDIDKKPTSSKANAPFITSTLQQTASTRLSFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALTMVREYVENHFGTDYLPAKPNFYSSKENAQEAHEAIRPSDVRVKMSDLKGMEKDAERLYDLIWRRFVACQMPPARYDSTSLTITAGDYELKAKGRVLRFDGWTKVLPIQGKTAEDQELPAVMLNEKLTLAEIIPSQHFTKPPAHFSEAALVKELEKRGIGRPSTYATIISTIQERGYVRTENRRFYAEKMGEIVTDRLDESFSDLMNYDFTANMEETLDQIAKGNKNWKEALNSFFSDFSEQLSKAELDELEGGMKPNSLVVTDIDCPTCARKMAIRTASTGVFLGCTGYALPPKERCKTTMNLILEAELFNVLDEESEAKALLARKRCPKCGSAMDSYIIDPTRKLHICGNNPNCDGHIVEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMACTACDNTSKILKNGEVAPPREEPTHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELALYRDRLPAKLQYLADAPQQDPEGNQAIIRFSRKEKRQYVTSEKEGKATKWIVDFIDGKWLERHK
(842) DNA topoisomerase 3 [Pasteurella multocida 36950]
10
MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGADDYVTWCIGHLLEQAEPDAYDPKFKQWRLEHLPIIPEKWQLIPRKDVHKQLTIVEKLIHQADILINAGDPDREGQLLVDEVFSYANLSVDKLNQIQRCLISDLNPSAVEKAVNKLQSNRNFIPLATSALARARADWLYGINMTRAYTLRGRQAGYQGVLSVGRVQTPVLGLIVRRDLEIENFKPKDFFEVLAHIQAETPEKITALSAQEKADIPQFKALWLPSKACEDYQDEEGRVLSLGLVENVVKRIAQQPAEVVEYVDKREHESAPLPYSLSALQIDAAKRYGLSAQEVLDICQRLYETHRLITYPRSDCRYLPEEHFAERTKVFQAISRHISDYQPLPDILNPEQKNRCWNDKKVEAHHAIIPTAKNTPVNLNQREWQIYHLIARQYLMQFCPDAEYRKSKITLNIAGGSFIAQARNLQVAGWKQLLGKEDSDEQQEPLLPVVKKGQILFCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTETGRILIQALPDVATQPDMTAHWESQLTSISQKEMSYQQFMSTLTNFLPELMRYVNFAALRQLSQVEKPPSFSKKTSAKSKKRPT
(914) DNA topoisomerase 1 [Pasteurella multocida 36950]
9
MSKSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTVGSSNGEKAKAISTKGLSAEEKSAIKQEKDRNALVKRMGIDPYHQWKANYQILPGKEKVVAELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDARFSRVVFNEITKNAIQQAFEKPEQLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPEEYWEIDVLTQTQAKQALRLAVTQFKGKKFEPKNATQAQSAVDFLQHADYVVSDLETKPTHSRAKAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALKMVRGYIQSHYGESYLPSKPVFYSSKENAQEAHEAIRPSDVNTLAEQLTGMDKDAVRLYDLIWRQFVACQMPAAQYDSTTVTVRAGEYELKAKGRILRFDGWTKVLPTMSKNAEDQVLPDVQLNEKLHLEHVLPEQLFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNQSFTALMNYDFTANMENILDQIANGEKNWKTELNQFFKDFSQQLSQAELDELEGGMKPNSLVPTDINCPTCGRKMAIRTASTGVFLGCSGYALPPKERCKTTMNLIPEAELLNVLDEASETKALMERKRCPKCGTAMDSYLIDPERKIHICGHNPNCDGYVLEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMGCTSCDNTRKILKSGEVAPPKEEPTHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELALYRDRLPEKLRYLADAPQHDPEGNDAIVRFSRKEKRQYVTSEKNGKATKWIVDYLGNQWVERKK
(876) DNA topoisomerase [Pasteurella multocida 36950]
4
MKLFICEKPSQARDLAGVLGATSKGEGLLATADKSIIVTWGFGHLVEQYQPEDYDEAWKRWAFETLPIIPAQWKMTPKKESKKQYSVVIGLIKKATSVVIATDADREGEMIARELLDLAGYRGQIQRCWLSALDDASIRKALQTLKSGKETEALYYAGMGRSRSDWLIGMNFSRLFTLMAQAKGYSGKPLSVGRVQSPTLTLVVNRDREIANFVPKSHYALAVQLTTTSGETFVAGLAVPEQYLDESGLCLDSRVIQQAEAQIKQTGLAKVVTVETKREKKSPPLLYALSDLQGECNRLFGFGAQQVLDIAQSLYEEHKITTYPRTDCGYLPESQFSDVPNVIRSLVASDSGLQTLLPKLNLRQKSRAWDDKKITAHHGIIPTIKKADLSKLSEEEMKVYDLIRRRYLAQFLPHLEMDKTVATLQSSGHTLVARGNVIVAQGWRILFGKNVDEETGNDDEKQGLPVLTKNQQCNVTHSEVRTLQTKPPAHYTEGTLLDAMKNAARFVTDPRLKQRLRETEGLGTEATRAGLIQGLIDKGFLLKKKKSLVASAEAVALIDSLPDLLKNPGLTALWEQALNQIAEGSMTLDAFMQKQEAFVKQLIGSCMQQGMSLGNIEIRKCSECGKPMRKINHAKGTFWGCTGYPDCQHKEADKKVKSASNKSAKKSSNLNVLDQLNKLRSQL
(49) DNA topoisomerase 3 [Aggregatibacter actinomycetemcomitans D11S-1]
10
MRLFIAEKPSLGRAIADVLPKPHQRGDGFIKCGENDCVTWCVGHLLEQAEPDAYDARFKQWRLEDLPIVPQKWQLIPKKETHKQLKTVEKLVQQADVLVNAGDPDREGQLLVDEVFSYLNLSAEKRNAIQRCLISDLNPSAVEKAIKKLQPNRDFVPLATSALARARADWLYGINMTRAYTIHGRQAGYDGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVLAWVRDPKGEKTPEKPTALFSALWQPSKACEDYQDDDGRVLSRALTENVVKRIADQPAEVTDYTDKREKETAPLPYSLSALQIDAAKRFGMSAQEVLDTCQRLYETYKLITYPRSDCRYLPQEHFADRMAVMNAISSHLSQFQPLPEIIDPEQKNRCWNDKKVEAHHAIIPTAKNRPVGLTSAEQNVYFLIARQYLMQFCPDAEYRKCKITLNIAGGTFVAQARNLQIAGWKQLWGKEDSDDEQQDALLPVVKKGQILHCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTEAGRILINALPDVATQPDMTAHWESQLDGISRKQASYQQFMENLTQLLPELLHYINFSALRELSRHNSGVKKQGIKKKTSRITKS
(825) DNA topoisomerase 1 [Aggregatibacter actinomycetemcomitans D11S-1]
9
MSKSLVIVESPAKAKTINKYLGNNYVVKSSVGHIRDLPTVGSSTGEKAKAISTKGLSAEEKQAIKHKKEQEALVKRMGIDPYHSWKANYQILPGKEKVVAELKSLAKKVDHIYLATDLDREGEAIAWHLREVIGGDDERYSRVVFNEITKNAIKQAFEHPEHLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLIVEREREIKAFVPQEYWEVSVLTNTPKGDEIRLDVVQFKGKKFEPKNAEQAQSAVDFLSKSDYVISDLETKPTSSRPRAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMVRGYIEKQYGQTYLPAKPNFYSSKENAQEAHEAIRPSDINVGLDDLAGMEKDAVRLYDLIWRQFVACQMPAAQYDSTTLTVTAGDYSLTAKGRILRFDGWTKVLLQQSKSAEDQALPAVSVNDKLNLSEVQPQQYFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFADLMNYDFTANMEDVLDQIASGDKNWKTELNQFFKDFSTQLTKAELDELEGGMRPNNLVETDICCPTCGRNMAIRTASTGVFLGCTGYALPPKARCKTTINLVPEAELLNVLDDASETKALMERKRCPKCGTAMDSYIIDPHRKLHICGNNPNCDGYLVEEGKFKIKGYDGPIVECDKCGGDMHLKLGRFGKYMACTQCDNTRKILKNGEVAPPKEEPIHFPELKCEKSDAYFVLRDGAGGVFMSAHNFPKSRETRAPKVAELALYRERLPEKLSYLADAPQTDPEGSEAIIRFSRKEKRQYVTSEKNGKATKWIVDFVDGKWVERKK
(628) DNA topoisomerase 3 [Mannheimia succiniciproducens MBEL55E]
10
MRLFVAEKPSLARAIADVLPKPHQRGDGFIKCGKNDCVTWCVGHLLEQAEPDAYNPMFKQWRLEHLPIVPKKWRLIPRKEVAKQLKTVENLIHQADQLVNAGDPDREGQLLVDEVFNYANLSTDKRNAIQRCLVSDLNPAAVEKAVKKLQPNTNFIPLATSALARARADWLYGINMTRAYTIRGRQAGYNGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFFEVLAHIQTEDETPQKFTALWQPSKACEDYQDDDGRVLSLGLAENVVKRITGQPAEVTEYTDKREKETAPLPYSLSALQIDAAKRFAMSAQDVLDTCQRLYETHKLITYPRSDCRYLPNEHFAERMPVLNAISTHCKEYQPLPEVLNTEQKNRCWNDKKVEAHHAIIPTAKNRPVNLNSQELNIYTLIARQYLMQFCPDAEYRKSKISLKIAGGNFVAQARNLQIAGWKELLGKEDENEQLEPSLPIVKKGQQLFCEKGEVISKKTQPPKPFTDVTLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSSEAGRILIQALPDMATQPDMTAQWEAQLDGISRKQASYQQFMATLTELLPELVQFVNFSALRKLSAVANNPKPKNFKKKAKIAQSTETKKEV
(87) DNA topoisomerase 1 [Mannheimia succiniciproducens MBEL55E]
9
MSKSLVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTAGASTGEKAKPVSTKGLTAEEKQALKTEKEKNALVKRMGIDPYHGWKANYQILPGKEKVVADLKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDNRFSRVVFNEITKNAIKQAFEKPEHLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPQEYWEVAVVTKTADNQKITLDVAEYKGKRFDPKNETEAQSAVDFLAKSDYIVSALETKPTTSRPRAPFITSTLQQTASTRLNFSVKKTMMLAQRLYEAGYITYMRTDSTNLSRDALNMARSYIERNFGEKYLPEKPNFYSSKENAQEAHEAIRPSDVNISMNDLQGMEKDAVRLYDLIWRQFVACQMPAAQYDSTTLTVKAGDYELKAKGRILRFDGWTKVLPQLGKSAEDQELPALNVHNKLALDEIQPSQHFTKPPARFTEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFAHLMSYDFTASMEDMLDQIATGKKDWKTELNQFFKDFSGQLTTAELDELEGGMKPNSLVLTDIQCPTCGRPMAIRTASTGVFLGCSGYALAPKDRCKTTINLIPEAELLNVLDDASETKALMERKRCPKCDTAMDSYIIDPHRKIHICGNNPNCEGYLIEQGTFKIKGYDGPIVECDKCGSDMHLKLGRFGKYMACTACDNTRRILANGEVAPPKEEPIAFPELKCEKADAYFVLRNSAVGVFMSAHNFPRVRESRPAKVAELAQYRERLPEKLQYLADAPQQDPEGNPAIISFSRKEKHQYVTSEKNGKKTKWIVDYIDGNWIERKK
(785) DNA topoisomerase 3 [Oceanimonas sp. GK1]
10
MILYIAEKPSLARAMAEVLPKPQQKGDGFIRLANGDVVSWCIGHLLEQAEPDAYDPAFKQWRREHLPIIPDDWKLVAKPNTKKQLAVLKKLLKEADSIVHAGDPDREGQLLVDEVISYCNVPAAKREAVQRCLISDLNPAAVKKSLATLKPNKDFVPLSVSALARSRADWLYGINMTRLCTLAGRSTGYNGVLSVGRVQTPVLGLVVRRDRDIADFRPKPFYEVLALLQTDSKAQFRAKWQPSEACQPWQDEEGRVLSRALAENVIRRITGQPGRVLAADNKRQRIPPPLPYNLSALQIDAARRFGLSAKQVLDLCQGLYERHKLITYPRSDNRYLPAEHFGQGPAVLAAIAAVCPGLSQAVAAADTGIRGRAWNDARVEAHHAIIPTTRHTDGARLSGTERQIYELIARQYAAQFYPHQELDEKKVELEIAGGRFVARARQQQVAGWKALFTQGKADEEEDDELQAQLPALKTGDTVQCLQGELQEKQTQPPRPFTDATLLSAMTHIARFVTDGELKKILRDTDGLGTEATRAGIIELLFTRGFLERRGRQIHATETGSRLVDSLPASATTPDMTARWEAVLDAISRKQAGYRQFMEELQGQLPMLIDSVKPDAFRGLQGGKPPRKRRGPVRRRARG
(1804) DNA topoisomerase 1 [Oceanimonas sp. GK1]
9
MSKSLVIVESPAKAKTINKYLGRNYVVKSSVGHVRDLPTAGSAGGKKPAARKTDTKQLSPEEKARLKKEKEHKALIARMGVDPEHGWKADYQVLPGKEKVVSELQALAEKADTVYLATDLDREGEAIAWHLKELIGGDDSRFKRVVFNEITKSAIQDAFSQPAELNLNRVNAQQARRFLDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEKEREIKAFVPEEYWDIQAALSNEQQLALSMMVAKYQGKEFRPTNEADAMAAVTALRASSFEVASREDKPTQSKPPAPFITSTLQQAASTRLSFGVKRTMMLAQRLYEAGYITYMRTDSTNLSQEAVASVRDFIEQHHGSAYLPESANVYGAKANAQEAHEAIRPSDVTLSADQLDGMEADAKRLYDLIWRQFVACQMTPAQYDSSTITVRAGDYELKARGRILRFAGWTRVLSPQSRKGEDTELPAVQAGETLSLNELTPKQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVADRLQESFAELMNYDFTAQMESKLDEIAGGKLDWTQVLDAFYAEFSDELEKAEQPAEEGGMRANQMVLTDIDCPACGRKMGIRTATTGVFLGCSGYALPPKERCKQTINLIPGDDFVLANDEEAETDALRAKHRCSKCGTAMDAYLIDDKRKLHVCGQNPDCDGYELEQGQFKLKGYEGPVIDCDRCGAEMQLKSGRFGKYMACTSEACKNTRKILKNGEVAPPKEDPVHLPELPCSQSDAYFVLRDGAAGLFMAASNFPKSRETRAPLVEELVRFKDRLPAKFRYLAEAPTEDPDGNKAVVRFSRKNKEQYVMTEVNKKATGWTAHYVDGKWQQHQKGKK
(186) DNA topoisomerase 1 [Tolumonas auensis DSM 9187]
9
MGKALVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTSGSASTSANKEGVKKATKPSAADKAQKEYSSLVSRMGIDPEHGWKARYEILPGKEKVVAELRALAAQADIIYLATDLDREGEAIAWHLRELIGGDESRFKRVVFNEITKTAIQEAFSHPGLLNIERVNAQQARRFLDRVVGYMVSPLLWKKIARGLSAGRVQSVALRLIVEKERDIKAFVPEEYWDIHADTQTPTRETLRLQVTAQQGKTFDPKNEQQAMAAVQTLKNAAYQVRDREDKPTSSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVVTVREYIEQQFGKKYLPKEPLTYGSKANAQEAHEAIRPSNVEVKADTLKDMEADAVRLYDLIWRQFVACQMTPAQYDTSTLTVTAADFELKAKGRILRFAGWTKALPPMGRKGDDIELPAVNAGDVLQLIKLDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLVESFADLMSYDFTAQMENSLDNIAQGKLDWHKQLDEFYAEFKSDLQKAEGEAGGMRSNQMVLTDIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKQTINLVPGDEYIAADSEDGEVDALLAMHRCKKCGTAMDSYVLDATRKIHICGNNPDCDGYEIETGQFRLKGYEGPVVECDRCGSDMQLKTGRFGKFMACTNAECKNTRKILKNGDVAPPKEDPVFLPELKCSKSDAHFVLRDGAAGLFMAASTFPKSRETRAPLVAELLRFKDRLAPKHQYLAEAPVADPEGNPTIVRFSRKTKEQYVASEVEGKATGWAAYYTNGRWQVSAGKGK
(1681) DNA topoisomerase [Tolumonas auensis DSM 9187]
4
MRLFLCEKPSQGKDIGRLLGARQRGNGCLNGPGVVVTWCIGHLVEAAPPEAYDEQLKRWTIEQLPIIPQHWRVEVKPKTAAQFKVVKDLLSKATELVIATDADREGELIAREIIDLCGYRGPIQRLWLSALNDASIHAALGKLKPSGDTLPMYHSALARSRADWLVGMNLSRLFTLLGRRAGYDGVLSVGRVQTPTLRLVVDRDREIAAFVSVPFWSIEVALSCTGQTFTAQWLPPSASTDDAGRCLQEPVAQQAVQRIRAAGAAQMVSVETERMREGAPLPFDLGTLQEVCSKQFGLDVQETLEIAQSLYETHKATTYPRSDSGYLPESMHAEAPTVLDSLLKTDPSLRPIIDQLDRTQHSRAWNDAKVSAHHGIIPTLEPANLSAMSEKELAAYRLIRAHYLAQFLPPHEFDRTTARFSCGDQTLQAVGKHVVVPGWRLVLAEPQPDDAGDDAAPRSQVLPALHQGLACQVAGVDLKALKTLPPRPYTQGELVKAMKSVAKLVSDPRLKQKLKDSVGIGTEATRANIIGGLLNRGYLIKKGRAIRASDAAFTLIDTVPAAIADPGTTAVWEQALDMIETGQLALDTFIDKQAAWVTQLIAQYRGTSLSIKIPEGPACPQCGGATRQRSGKSGPFWSCAKYPDCKGTLPIESGKRAAPRKRRGGPKAS
(163) DNA topoisomerase [Marinobacter adhaerens HP15]
7
MHLYIAEKPSLGRAIAAALPGPHQKGQGWIRCGTGENAATVSWCIGHLLEPAEPARYNPAWKKWRQEDLPMFPDKWEVMPKDSVQQQLKVLESLIRQAKTIIHAGDPDREGQLLVDEVIRYFGASAPVQRILINDLTPAAVARAIQSPRDNREFRRLSHSALARQRADWLYGINLTRFYTLSYQRQGEQGVYSVGRVQTPVLGLVVERDTTIEHFQPKPYYRIEARFRAQEEEADQQTFTARWQPNEQFQDYLDEENRLLNREVAEQIADSVRNRPGTITESRFRDRSEAPPLPFSLSALQIEAGRLFRMGAKDVLDTAQNLYERHQLITYPRSDCRYLPEGHYSQREQVIRAIARVAPDLEEACNGADLGRRTSAWNDKQVDAHHAIIPTSRPTPNGKLSDAEEKIYGLISRYYLMQFAPDAVHREGKLTVRVSEHEFRATETAILVPGWKTLELKLREARKEPEKAPLPRLEKGEPVFCDDSSLSERKTQPPQHFTDATLLSAMTNIARFVTDTELRKTLRETDGLGTEATRAAIIDTLFKRDYLYRDSRHIRATDKAKALISALPESVSKPDRTAVWEANLESIRRGEGDPRKFLDTLKEEIRGFLDRPQGRPTVDSESIGTTSPEAQPHCPKCRAPMLEREGKFGRFFACTRYPDCRGTRPLEEATPQDGTGQKPIPCPHCFSPLVRRKGKKGWFWGCSNFPGCRQTLDDDNGKPSVRLRKST
(1173) DNA topoisomerase 1 [Marinobacter adhaerens HP15]
9
MGKSLVIVESPAKAKTINKYLGSDFIVKSSVGHIRDLPVSGSGSQSDPKERAKQAAITRKMSPEEKAVHKKRKSREQLVARMGVDPDQDWSARYEILPGKEKVVSELKRLAKSADHIYLATDLDREGEAIAWHLQQTIGGEPEKYRRVVFNEITKRAIQEAFKDPGTLDNNRVNAQQARRFLDRVVGYMVSPLLWAKLARGLSAGRVQSVAVRLIVEREREIRKFVPEEFWQLHADLASAKADQPVRFEVTRHEDKPYRPVNEQQSSDHVSRLKAGTFKVAKREDKPTRSRPSAPFITSTLQQAASNRMGFSVKKTMMLAQRLYEAGFITYMRTDSTNLSQDAINSCRAYIEKQFGDKYRPEKPRVYGSKEGAQEAHEAIRPTEVSRRPADISGLEKDAEKLYDLIWRQFIACQMSDAEFLSTSIVVANGDYELRTRGRIIKFDGFLKAAPQAAKKDEDIALPDIKVDEVLDLKKLDPTQHFTKPAPRYTEASLVKELEKQGIGRPSTYASIISTIQDRGYVRLQNRRFYAEKMGEIVTERLSESFPNLMDFDFTARMEDELDEIAEGDVEWKKVLNDFYGRFRQQLEKAESGEDGGMRANTPTETDIPCPSCGRNMQIRVASTGVFLGCSGYSLPPKERCKTTINLVSGDEVVSADDDVEGEGETRLLRKKRRCPKCGTAMDSYLVDETRKLHVCGNNPDCSGYEVEKGTFRIKGYDGPTLECDKCGSEMQLKTGRFGKYFGCTNAECKNTRKLLKNGEPAPPKMDPVPMPELQCQKVDDTYVLRDGASGLFLAASKFPKNRETRPPLVMEIKPHRKEIDPKYDYLMDAPERDPEGNPTVIRYSRKSKEQYVMSEKDGKATGWSAWYVNGKWQPQDKKK
(1049) DNA topoisomerase [Halomonas elongata DSM 2581]
7
MRLIIAEKPSLARAIANALPASPRREEGALVAGDTVVTWCLGHLLEQAPPDAYDPALKTWRLDSLPILPDHWKLMPRPKARGQLAVIRRLLKSADQVVHAGDPDREGQLLVQEVIEHLGWKRDVARLLVSDLNPPAVKRALERLEDNRRYASLYRAAQARARADWLYGINLTRAWTLVGRQAGHDGVLSVGRVQTPVLGLVVRRDAEIRDFEPRPFFVLWVDLVVSRGQLRAWWVPGDTHRLDDQGRLLDRAPAAALADRLPGAEGRLDSLASRDKRQAAPLPYSLSALQVDAARRHGLSAKAVLDVCQRLYERHQLITYPRSDCRYLPEEHFAQAQRTLSGACRNDETLSRWLAGADFSRRSKAWDDKKVGAHHALAPTGKPADLDRLSRQEADVFRLIARNVLAQFYPALQTREVKAEFLIAGERFRARGQEVLEPGWKPLFTTRDEAPPLPPLSEGEACRVEQAGVEDRETRPPEHFTDASLIKAMMNIARYVDDPAIRRTLRDSDGLGTEATRAGIIETLLERGYLVREGKSLKASRLGSALIASLPEAVGRPERTAQWEQRLANIAEQDDAPAPFLEGLIDDLRGLLGHADAGRVRSALSEARGPEPKASKPARGRGRSTKRGSGQRRQGKGTRRAAGGKRQ
(346) DNA topoisomerase 1 [Halomonas elongata DSM 2581]
9
MGKSLVIVESPAKAKTINKYLGNEYIVKSSVGHIRDLPTSGSGKAASDPKERARQAAATRKMSAEEKAEYRKRKAHDQLIRRMGIDPDHGWEAEYVVLPGKEKVVAELKKLADKADNVYLATDLDREGEAIAWHLRETIGGDESRYRRVVFNEITKNAIQEAFEDPGQLNMPRVEAQQARRFLDRVVGFMLSPLLWAKIARGLSAGRVQSVAMRLIVEREREIRAFVPEEFWDVHADLSPRDGNGETVRFELARQDGKTFRPTSETETLERIAALREANLVITSREDKPTRSRPNAPFITSTLQQAASGRLGFSVKKTMTLAQRLYEAGYITYMRTDSTNLSQEAVAGARDYIGEAYGKPYLPETPNRYTSKEGAQEAHEAIRPSDVTRRAGDLAGMERDAERLYELIWRQFVACQMTPAEYLSTTLTVEASGYELRAKGRVLKFDGYTRVMAPMGRKDEDQSLPDLAEGTALTLEALDPQQHFTKPPARYTEASLVKELEKKGIGRPSTYASIISTIQDRGYVRLENRRFYAEKLGDIVTERLKESFPDLMDYSFTARMEDSLDEVAEGQRRWRELLDAFYAEFREELKVAESEEGMRPNQPVPTDIECPTCGREMQIRTASTGVFLGCSGYNLPPKERCKTTMDLLPGDEAVAADAGEEAETDALRAKHRCPKCGTAMDSYLIDEQRKLHICGNSPDCDGHEVEEGRFRIKGYDGPTIECDKCGSEMQLKSGRFGKYFGCTNDTCKNTRKLLRNGEVAPPKMDPIPMPELACQKVEDHYVLRDGASGLFLAASKFPKNRETRPPLVVELQAHADELPEKYRYLLDAPSADPDGRPAQIRFSRKTKEQFVMTDDNGKATGWKATFADGRWQVEDKRK
(704) DNA topoisomerase [Halomonas elongata DSM 2581]
4
MSRLFLCEKPTQARDIAKVLGASEKGNGCLKGRGITVTWGFGHLLEQANPEAYDPALKRWSMESLPILPTQWKLEVKPSAKKQFTVVKKLLSSASEVVIATDADREGEMIAREILEACQFSGGVSRLWLPALDEASIRKALGDIRPGESTRLLYHAALGRSRADWLVGMNLTRAFTMRAKQLGYDLLLSVGRVQTPVLKLVVDRDREIANFVPKPFWEVVAVFQAEGGTFQAKWQPADDDVLDESGRCINQSAAQAVVARCQGLPGQVTTLETTRKREAPPLAMDLGTLQQTCSKRWGYGAQQVLDIAQALYETHKATTYPRTDCRYLPLSQLDDAQQVVTALLTSDGELAPVVQSLDLTRKSRVWNDSKITAHHGIIPTTSPCDTSKMSEAEWNVYDLVRRHYLAQFLPPHEYDHTDVALEVAGERFATTGRQVQVEGWKVLFRNVQQDDAAGDEATAKTSSQALPPLQAHANVPQSSLDLVSKTTTPPKPFAEGTLIGAMKNAARFEPNPKLKARLKESAGIGTEATRAGIIETLLKRKFLTKKGRAIVATATGRQLIDALPEVVTNPGMTALWEQALDSVAAGELSLEDFMAKQQTLVERLIEQAKSATINLPQEPAKSKACPECGAPMKKRKNDYGSFWGCTKYPDCKGMVKIGSGKKRQGKGRKASNG
(1318) DNA topoisomerase 1 [Xanthomonas oryzae pv. oryzae KACC 10331]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNSFAMRYDLIEKNEKHVEAIARAAKGADDIFLATDPDREGEAISWHIAEILKERGLLKDKPMQRVVFTEITPRAIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIDAHCRHPSQAFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALSEIRDVIARDYGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVPGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTAKLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGTDPVSGKEVSARIGRFGPMVQIGSVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKDFEGSDIQVLNGRFGPYISDGKLNGKIPRDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVKDSAPKKPAAKKTATKTAASKTAAKKAPAKKAAAEKGTKRVVKKTVSKAAD
(31) DNA topoisomerase 1 [Xanthomonas campestris pv. campestris str. ATCC 33913]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNGFAMRYDLIEKNEKHVEAIARAAKSADDIYLATDPDREGEAISWHIAEILKERGLLKDKTMQRVVFTEITPRAIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIDAHCRHPSQPFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALAEIRDVIARDFGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVAGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTANLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGADPVSGKEVSARIGRFGPMVQIGTVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKEFDGSDIQVLNGRFGPYISDGKLNGKIPKDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVKDSAKEAKDAAKKTAAVKKVATKTAAKKAPAKKAAKKATKRVVKKAVSKAAG
(1596) DNA topoisomerase 1 [Methylomicrobium alcaliphilum 20Z]
1
MSNNLVIVESPAKAKTIEKYLGKDFHVLASYGHVRDLVPKEGAVDPEHDFAMKYEIIERNQRHVQAITKAIKQAQALYLATDPDREGEAISWHLYELLKDKKLLKDKPVHRVVFHEITKKAVTEAIAHPAELSIDLINAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSREYWTIDAELSAEEQAFKAKLTHFEGEKVEQFTIDNEERALQVKQTLFDAADGKLLVAKVEKKQRKRNPAPPFITSTLQQEAARKLGFTTKRTMMVAQQLYEGIDIGGETVGLITYMRTDSVNLAAEAIAEIRELIAEKYGAKNVPKSPRDYKTKSKNAQEAHEAIRPTSARRIPVELQKFLSPEQFKLYDLIWKRTISSQMVHATINTVAVDLHCGSERNVFRATGSTIADPGFMAVYLEGKDDTAEGDDKENFLPSLEEGRPVPLNDIIAGQHFTEPPPRYSEASLVKALEEFGIGRPSTYASIISTLQNRDYVTLESKRFYPTDVGRIVNKFLTEHFNKYVDYDFTANLEDELDAVSRGEKDWIPLMRSFWEPFNTLIHEKEESVQRKDVTQEAIDEKCPECGSPLSIRLGRNGRFIGCTNYPECSYTRNLNEDASKSSEPEVVEGRVCPKCESPLVIKTGRYGKFIGCSSYPKCKHIEPLEKPVDTGVECPQCKKGNLLKRKSRNGKIFYSCSEYPKCSYAIWNAPVQENCPECNWPILTLKTTKRRGTEKVCPQKECSYATPYEGDPDDVLGPKG
(970) DNA topoisomerase 3 [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
10
MRLFIAEKPSLGRAIADVLPKPHKKGDGFIETAQGDVVTWCIGHLLEQAEPDAYDAAYKQWRMESLPIVPSQWQLVAKPKTKTQLTVIKRLLKQADCVVNAGDPDREGQLLVDEVIDFLGYGKTRPVLRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYTLLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFFEVLAHLQTEGNERFSAKWLPSEACLPWQDEEGRVLNRALAAKVVERIQGQPALVEEVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDVCQGLYERHKLITYPRSDSRHLPSDHFNRAGQVREAIASTAPALAKAVSEADGKIRSKAWNDGKVDAHHAIIPTEKQGNPATLGADEAKLYGLIARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGALLEKMTQAPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIIDLLFKRRFLVRQGKSIKGTPTGRALILALPATATTPDMTALWEQHLGRIAERQTSYQQFMGPLTEQLNGLIDGARQDSGASFSALPKAVPGADKRRFTKRKRSTAAGGTSGTAKRGSKRPAKAA
(470) DNA topoisomerase 1 [Aeromonas hydrophila subsp. hydrophila ATCC 7966]
9
MGKSLVIVESPAKAKTINKYLGKDYVVKSSVGHVRDLPTSGSASNEPKKPVIRGIKLSEAEKAAKDRNALFSRMGINPTAGWQANYQILPGKEKVVSELQSLAEKADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKTAIQEAFAQPSELNIHRVNAQQARRFLDRVVGYMVSPLLWKKLARGLSAGRVQSVAVRLIVDKEREIKAFVPVEFWDLNADLLTADKSDLRMEVVSRNGVDFKPVTQAETFAAVAALEGVDYKVVNREDKPTGSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVEAVREYIGEQYGAAYLPSDPNLYGAKANAQEAHEAIRPSSVLVTAEMLEGMEPDAMRLYDLIWRQFVACQMTPAQYDSSTLTVKAGEFELKARGRTLRFAGWTKALPPMGRKGEDSQLPAVTVGEILKLVKLDPRQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIVDRGYVRVESRRFFAEKMGEIVTDRLVENFVELMNYEFTAKMEDKLDGIAEGSLEWKKVLDAFYAEFTQELEKADKAPEEGGMRANQMVLTDIDCPDCGRKMGIRTATTGVFLGCSGYALPPKERCKKTINLVSADEFVSATDGEEAETEALRAKHRCTICGTAMDAYIIDDSRKLHVCGRNPDCDGYEIEKGQFKLKGYEGPSIECDRCGSEMQLKNGRFGKYMGCTNDTCKNTRKILKNGDIAPPKEDPVPLPELKCTQSDAHFVLRDGAAGLFLAASNFPKSRETRAPLVEELKRFKERLSPKHQYLADAPASDPDGNAAIVRFSRKTKEQYVMTEVNGKATGWTAHYDNGKWQESLAKSKKA
(1729) DNA topoisomerase 1 [Aeromonas veronii B565]
9
MGKSLVIVESPAKAKTINKYLGKDYVVKSSVGHVRDLPTSGSASTEPKKPVIRGIKLSESEKAAKDRKALFARMGINPTAGWQANYQILPGKEKVVSELQSLAEKADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKSAIKEAFAQPSELNIDRVNAQQARRFLDRVVGYMVSPLLWKKLARGLSAGRVQSVAVRLIVDKEREIKAFVPVEFWDLNADLLTGDKSDLRMEVVSRNGADFKPVTQAETFAAVAALEGVDYKVVNREDKPTGSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVEAVREYIGEQYGAAYLPAEPNLYGAKANAQEAHEAIRPSNVQVTAEMLEGMEPDAMRLYDLIWRQFVACQMTPAQYDSSTLTVKAGEFELKARGRTLRFAGWTKALPPMGRKGEDSQLPAVTVGEVLKLIKLDPRQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIVDRGYVRVESRRFFAEKMGEIVTDRLVENFVELMNYEFTAKMEDKLDGIADGSLEWKKVLDAFYAEFTQELEKADKAPEEGGMRANQMVMTDIDCPDCGRKMGIRTATTGVFLGCSGYALPPKERCKKTINLVSADEFVSATDGEEAETEALRAKHRCGVCGTAMDAYIIDDSRKLHVCGRNPDCDGYEIEKGQFKLKGYEGPSIECDRCGAEMQLKNGRFGKYMGCTNETCKNTRKILKNGDIAPPKEDPVPLPELKCTQSDAHFVLRDGAAGLFLAASNFPKSRETRAPLVEELKRFKDRISAKHKYLAGAPLTDPDGNPAIVRFSRKTKEQYVMSEVNGKATGWTAHYDNGTWQESLPKAKKA
(1880) DNA topoisomerase 3 [Aeromonas veronii B565]
10
MRLFIAEKPTLGRAIADALPKPHKKGDGFIETAQGDVVTWCIGHLLEQAEPDAYDAAFKQWRMEHLPIIPAQWQLVAKPKTKTQLTVIKRLIKQADCVVNAGDPDREGQLLVDEVIDFLGYPKTKPVQRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYTLLGRKAGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFYEVLAHLLTEGNERFTAKWLPSEACLPWQDEEGRVLNRALADKVVSRINGQPAQVESVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDICQSLYERHKLITYPRSDSRYLPTDHFKRAEQVRGAIAATAPALAKAVSEADGKIRSKAWNDSKVDAHHAIIPTEKQGNPATLGADEAKLYGLIARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGELQEKMTQPPKSFTDATLLAAMTGIARYVQDPEIRKTLRDTDGLGTEATRAGIIDLLFKRRFLVRQGKSIKATPTGRALVQALPATATTPDMTALWEQSLGQIAERHGSYQQFMGPLTEQLNGLIEGARQDSGASFSALPKEAPGAGKRRFTKRKSPAASTTGGPRPRKTASKRQTRAA
(710) DNA topoisomerase 1 [Aeromonas salmonicida subsp. salmonicida A449]
9
MGKSLVIVESPAKAKTINKYLGKDYVVKSSVGHVRDLPTSGSGSNEPKKPVIRGIKLSESEKAAKDRNALFSRMGINPTAGWQANYQILPGKEKVVSELQSLAAKADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKTAIQEAFAQPSELNIHRVNAQQARRFLDRVVGYMVSPLLWKKLARGLSAGRVQSVAVRLIVDKEREIKAFVPVEFWDLNADLLTGDKSDLRMEVVSRNGADFKPVTQAETFAAVAALEGVDYKVVNREDKPTGSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGYITYMRTDSTNLSKEAVEALREYIGEQYGAAYLPAEPNLYGSKAGAQEAHEAIRPSSVLVTAEMLEGMEPDAMRLYDLIWRQFVACQMTPAQYDSSTLTVKAGEFELKARGRTLRFAGWTKALPPMGRKGEDSQLPAVTVGEVLKLIKLDPRQHFTKPPARFTEAALVRELEKRGIGRPSTYASIISTIVDRGYVRVESRRFFAEKMGEIVTDRLVENFVELMNYEFTAKMEDKLDGIAEGSLEWKKVLDAFYEEFTQELAKADRDAEEGGMRANQMVLTDIDCPDCGRKMGIRTATTGVFLGCSGYALPPKERCKKTINLVSADEFVSATDGDEAETEALRAKHRCGVCGTAMDAYIIDDSRKLHVCGRNPDCDGYEIEKGQFKLKGYEGPSIECDRCGSEMQLKNGRFGKYMGCTNETCKNTRKILKNGDIAPPKEDPVPLPELKCTQSDAYFVLRDGAAGLFLAASNFPKSRETRAPLVEELKRFKERLSPKHQYLADAPASDPDGNASIVRFSRKTKEQYVMTEVNGKATGWTAHYDNGKWQESLAKSKKA
(692) DNA topoisomerase 3 [Aeromonas salmonicida subsp. salmonicida A449]
10
MRLFIAEKPSLGRAIADVLPKPHKKGDGFIETAAGDVVTWCIGHLLEQAEPDAYDAAFKQWRMEQLPIIPAQWQLVAKPKTKTQLTVIKRLIKLADCVVNAGDPDREGQLLVDEVIDFLGYPKTRPVQRCLISDLNPPAVRRALDKLRDNKEFVPLAVSALARSRADWLYGINMTRAYTLLGRKGGCSELLSVGRVQTPLLGLVVRRDLEIEAFVPKPFYEVLAHLVTDGNERFSAKWLPSEACLPWQDEEGRVLNRALAEKVVSRINGQPASVEEVEEQARKQAAPLPYNLSSLQIDAAKRFGMDAKRVLDVCQGLYERHKLITYPRSDSRHLPSEHFNRAAQVREAIAATAPALARAVSEADGKIRSKAWNDSKVDAHHAIIPTEKRGNESSLSGDEAKIYGLVARQYLLQFYPPFEYNDSKVLLRIAGGLFQAKARRILKAGWKALLGVEEDDDEEKAGTLPALKEGEQLLCERGELLEKMTQAPKSFTDATLLAAMTGIARYVQDPEIRKTLRETDGLGTEATRAGIIDLLFRRRFLVRQGKSIKGTPTGRALILALPTTATTPDMTALWEQSLGQIAERHASYQQFMGPLTDQLNALIEGARQDSGASFSALPKAVPGAGKPHFTRRKSSAGTTGTPRKSAGKRPAKSKAT
(1613) DNA topoisomerase 1 [Aliivibrio salmonicida LFI1238]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPMGSTSTGKKTAAASTKGMSVEDKARIKKERDKKNLINKMGIDPYNDWAANYQILPGKEKVVAELQKLAENADTIYLATDLDREGEAIAWHLREIIGGDDSRYKRVVFNEITKNAIQQAFETPGELSMPGVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVKVLVEREREINAFIPEEFWDIHADTLTSGKENFRLQVAQRNGSVFKPLNQADTESAVSILEKAEYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKEAVETLREFIGSEYGESYLPAAPIIYGSKEGAQEAHEAIRPSSVDVKVDDLQGMEADAHKLYNLIWNQFVSCQMTPAQYDSTTLSVKADEFTLKAKGRILKFDGWTRVQRPMGKNEDQLLPAVQLGDKLKLEQLDPKQHFTKPPARFTEAALVKELEKKGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLNQSFDDLMDYDFTARMEGNLDKIAEGSKDWKEVLNAFFQDFTDDIAKAELDESEGGMSPNNIVETDIKCPTCDRNMGIRTASTGVFLGCSGYALPPKERCKKTINLGNEEGIINVLEEDVETAALRAKKRCPKCETAMDPYLIDQDRKLHVCGNNPNCDGYIVEKGEFQLKGYDGPIVECDKCGSDMELKNGRFGKYMDCTSETCKNTRKILRNGDVAPPKEDPVHLPELECEKSDAYFVLRDGASGLFLAASTFPKSRETRAPLVEELVRFKDRLSPKFVYLTEAPTHDPDGKPAVIRFSRKTKENYVRTETDGKPSGWTALYLDGKWAVTDKRKKPKAEKES
(1718) DNA topoisomerase 3 [Aliivibrio salmonicida LFI1238]
10
MSRLFIAEKPSLGRAIAAGLAKPQKNHQGYIECGNGDIVTWCIGHLLEQVEPDAYDDKYKSWRMEHLPIVPEQWQLRPRKSSSKQLTVIRKLLKTASQVIHAGDPDREGQLLVDEVLDYLKLSKTKKAATQRLLISDLNLPAVKRALSAMRSNQEFIPLSISALARSRADWLYGMNMTRAYTLLGQRGGYQGVLSVGRVQTPVLGLVTRRDEEIAHFIPNAYFTLDALIPYHNPNLNGGLPFDIRAKWKPSEACQQWQDEDGRVLNLKLVENVAQRIANQPATVTKAENKETKQNAPLPYSLSALQIDASKRYNLSAQQVLDSCQALYEKHKLITYPRSDSRYLPKDHYKQREQVCAAIGNNDKQLSNAVNNADVNLRSRAWNDSKVDAHHAIIPTPKSSGAAGLSGYEEKVYHLIARQYLMQFYPAAIYAEAELIFDIAGGVFSAKGKQMLFAGWRILLGKTHTQNADDDVANKVPPLKKGEVHTCREGEIKHKMTEPPKYFTEATLLQAMTGIARFVEDKELKKVLRDTDGLGTEATRAGILDTLFKRQLLIRNGKNINASDAGKGLIHALPREATYPDMTAHWEFQLQGMTEKTYSYRPFMQSLETKVTNFMQGVQQGPVPDSLRSLKSPTKPQFKRRKSAKKS
(225) DNA topoisomerase 3 [Vibrio parahaemolyticus RIMD 2210633]
10
MSRLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERYKKWNMADLPIVPQQWQLRPRKSASKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCKLSKTKKEATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDYFTLHALIPYQDQNGAFDIRARWKPSEACKPWQDEEGRVLNRKLVENVANRIANQPAIVKESEQKQTKQSAPLPYSLSALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPLEHYSQAGTVTSAIANNAKELQSAVNGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQFYPAAVYAEAKLVFDIAGGIFIAKGRQLVSPGWKALMGKTDKEDEGIDTVPPLSEGTVLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGILDTLFKRQLLTRQGKSILSSQAGRGLINALPQDATYPDMTAHWEHQLQGMAERNQAYQPFMQALEQRIDGLMSQVKSGPIPDSLRHLPKVERPAFKRKKRSYPNSGASKAGASKRKSS
(1253) DNA topoisomerase 1 [Vibrio parahaemolyticus RIMD 2210633]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQSTGEKKAAAISTKGMSAEEKARVKKEKDRKALIKKMGINPYHDWEANYQILPGKEKVVSELQKLAKDADCVYLATDLDREGEAIAWHLREIIGGDEERYKRVVFNEITKNAIQQAFQTPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFVPEEFWDIHANTKTKDKSDFKLLVAQKDGVAFKPVNETETKAAISVLENASYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVDAVRDFIGSEFGDKYLPAKPLTYGSKEGAQEAHEAIRPSDVSVKAEDLQGVDADAHKLYSLIWNQFVACQMTPAEYDSTTISVKAAEYTLKAKGRILKFDGWTRVQRPMGKNEDTILPAVQLGDKLSLESLDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEQKLDQIAEGEVNWKAVLDNFFADFTGDLEKAELDESEGGMKLNHIVMTDIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEEGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYVVEYGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHFPELPCENSDAYFVLRDGASGLFMAASNFPKSRETRAPLVSELARFEERLPEKFKYLTTAPQEDPDGRPAVVRFSRKTKENYVRSEDDGKPSGWTALYVDGKWEITDKRKKAKA
(612) DNA topoisomerase 3 [Vibrio anguillarum 775]
10
MTRLFIAEKPSLGRAIADALPKPHKKDQGFIRCANGDIVTWCIGHLLEQVEPDVYDERYKKWNLLDLPIIPSQWQLRPRKTSSKQLTVIRQLLKEASQIIHAGDPDREGQLLVDEVIDYCKVSQSKKEQALRLLISDLNLPAVQRALKQMRSNREFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPILGLVVRRDEEIENFIPRDYFTLHALIPYQTDQVAFDIRARWKPSDACQPWQDEEGRVLNRKLVENVAQRIAGQPATVIEAEQKQTKQAAPLPYSLSALQIDAAKRFAMSAQQVLDTCQSLYEKHKLITYPRSDCRYLPQEHYAQASSVTQAIACNAKELLTSVSGANLALKSKAWNDKKVDAHHAIIPTPKQTSVNALSGNEMKIYQLIARQYLMQFYPAAVYAEAKLVFDIAGGFFVASGRQLVDTGWKSLLGKVDEEENGVDAVPPLSKGTVLTCREGEIHDRKTEPPRHFTEATLLQAMTGIARYVEDKELKKILRETDGLGTEATRAGILDTLFKRQLLTRQGKLILSSPAGRGLIHALPNESTYPDMTAHWEHQLQAMAERGQAYQPFMQVLQERIIQIMEQAKSGAVPESLRSLPKVERPAFKRKTRKSSKTTRYQRNSAQ
(1695) DNA topoisomerase 1 [Vibrio anguillarum 775]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQSTAKKATSSSSSKNLSAEEKARLKSEKDRSSLIKKMGIDPYHGWEANYQILPGKEKVVAELQKLAKDADCIYLATDLDREGEAIAWHLREIIGGDEQRYKRVVFNEITKNAIQQAFQTPGELNIDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFVPEEFWDIHADTKTQDKTDFRLLVAQKNDVAFKPVNEAEAKSAVSILEKASYEVCKREDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVEAVRSYIGSEFGQAYLPENPLAYGSKQGAQEAHEAIRPSSVDVKADDLQGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEFTLKAKGRILKFDGWTRVQRPMGKNEDQILPPVKVGETLLLQTLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEEKLDQIAAGSANWKGVLDDFFKDFTADLETAELDEEQGGMKPNHIVMTDIQCPTCSRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEEGVINVLEEDVETAALRAKKRCPICETAMDAYLIDDTRKMHVCGNNPNCEGYVVEFGEFKVKGYDGPVVECDKCGSNMVLKNGRFGKYMDCTSDDCKNTRKILRSGEVAPPKEDPIHFPELPCENSDAYFVLRDGASGLFLAASNFPKSRETRAPLVEELARFKERLAPKYQYLADAPAHDPDGVAAVVRFSRKSKEHYVRTEIDGKPSGWTALYDNGRWEITDKRKNAKK
(642) DNA topoisomerase [Pseudoxanthomonas spadix BD-a59]
4
MRVVLCEKPSQGKDIARVLGATQRGNGCYTGSGLGVTWGIGHLIETAPPEAYGEQYKRWALEPLPIIPQHWQVVVKAKTATQFKVVKQLLAQATDLVIATDADREGEMIARELIDYCGYRGPIQRLWLSALNDASIRKALGALKPSGETLPLYYSALARSRADWLIGMNLSRLFTVLGRQAGYSGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWTIEVLLAHAGQSFVANWTPPAGCTDDAGRCLQQPVAQQADERMRAAVSAQVVSVETERMREGPPLPFDLGTLQEVCSKQLGLDVQETLDIAQSLYETHKATTYPRSDSGYLPENMLAEVPTVLDSLVKTDPSLRPLVAKLDPHQRSRAWNDAKVTAHHGIIPTLEPANLSALNDKELAVYRLIRAHYLAQFLPHHEFDRTVAQFACAGQSLTVVGKQIVVTGWRQVLAAPAPDEPDEDAQRSQVLPALHAGLSCPIGAVDLKALKTLPPKPYTQGELVKAMKGVARLVTDPRLKQKLKDTTGIGTEATRANIINGLLGRGYLLKKGRAIRASDAAFTLIDAVPPAIADPGTTAVWEQALDMIEARQMTLDAFIAKQSAWVAQLVQQYRTATLSIQLPPAPACPQCGSPMRQRTGKSGAFWSCSRYPDCKGTMAIESATGGKRSAPRKRRTAPKAS
(1405) DNA topoisomerase 1 [Pseudoxanthomonas spadix BD-a59]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNNFAMRYDLIEKNQKHVEAIAKAAKGADDIYLATDPDREGEAISWHIAEILKERNLIGNKPMHRVVFTEITPRAIKEAMARPRAIAGDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIAAACAHPSQPFTAKLVKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVTSKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGAVGLISYMRTDSVNLSQDALNEIRDVIARDYGTASLPDQPNIYLTKSKNAQEAHEAVRPTSALRTPSQVARFLSDDERRLYELIWKRAVACQMIPATLNTVSVELAAGSAHSFRASGTTVVVPGFLAVYEEGKDTRSAEDEDEGRKLPAMKPGDSVPLDRIVAEQHFTQPPPRFTEAALVKTLEEYGIGRPSTYASIIQTLLFRKYVEMEGRSFRPSDVGRAVSKFLSGHFTRYVDYDFTAKLEDELDAVSRGEEDWIPLMARFWGPFSQLVEEKKESVDRAEASGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEDKPRFASLRPGQSMHTISLEDALELFLMPRALGQDKGEEVSVGIGRFGPFAKRGSSYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKTFPDSQIQVLNGRFGPYISDGKLNGKIPKDRDPASLTGEEVIRLLEETGKPVRKGFGAKTPQKGAKTTARKVTKKAEPAEKKPTASKAVKKATGKTARNPGKGTGAASKLAAKKTVAKKSVAKKAASQGAAPF
(977) DNA topoisomerase 1 [Methylococcus capsulatus str. Bath]
1
MAQHLVIVESPAKARTIEKYLGKSFQVYASYGHVRDLIPKEGAVDPDHDFSMKYAIIEKNKKHVQAISKAMEKADALYLATDPDREGEAISWHLYELLKEQQVLDSKPVHRVVFHEITKRAITEAVENPKTLSTDLIHAQQARRALDYLVGFKLSPLLWKKIRRGLSAGRVQSPALRMIVERELEIERFEVQEYWTIEAAIQTEDQALSARLTHLAGEKLEQFSIVNEAQAQATRQSLLDQARGKLQVVRVEERERKRNPAAPFTTSTLQQEAARKLGFTTRRTMTVAQQLYEGIDLGGEAVGLITYMRTDSVNLAQEAVQELRALIESRYGKDNLPAQPRLYKTKSKNAQEAHEAIRPTSAFRTPESVKAHLTPDQFKLYSLIWKRSVACQMVHATLNTVTVDFACGSADNLFRATGSTVIHPGFMSVYREGRDDMPEESDEIYLPKLVEGQEVDLKDVTPSQHFTEPPPRYTEASLVKALEEYGIGRPSTYATIISTLQQRHYVELENKRFRPTDLGRVVNKFLTEHFNRYVDYNFTANLEDDLDAVSRGEKDWIPLMREFWGPFHALIGEKDESLKRADVTHEAIDEKCPECGSPLSIRLGRNGRFVGCTNYPQCKYTRNLAGKESEQTEPEVVEGRQCPKCHSPLVIKTGRYGRFIGCSGYPACRHIEPLEKPTDTGVPCPECGQGTLTKRKSRFGKLFYSCSTYPKCSYAVWNPPIAEACPACQWPVLTLKTTKRRGTEKVCPRKECGYAAPYEGEPLTDFAA
(1370) DNA topoisomerase [Xanthomonas axonopodis pv. citri str. 306]
4
MRVVLCEKPSQGKDIARVLGAHRREAGCLGGPGITVTWGSGHLIEAAPPEAYGEHFQRWTLPIVPPRWQWVVKARSAAQFKVVKRLLGEASELIIATDADREGEMIAREMIDYCGYRGPVQRLWLSALNDASIRKAFGALRASSETLSLYHCALARSRADWLVGINLTRLFTLLGRHAGHDGVLSVGRVQTPTLKLVVDRDREIAAFVPVPFWSIDVSLSAANVPFSAHWLAPRTATDDAGRCLRQSVARHAADAIRAAGTAQVVHTETERVREGPPLPFDLSTLQEVCSRRLGLEVQETLDIAQALYETHKATTYPRTDAGYLPENMLAEVPTVIQSLVKTDPALQPLIDRLDFRQRSRAWNDAKITAHHAIIPTLEPADISAMSAKELAVYRLIRAHYLAQFLPHHEFDRTVVRFRCGGETLQAVGKRIAVPGWQHAFSAPSLPHVAADGADTEGSDEAPREQMLPVLQEGISCQVSALDLKSLSTKPPRPYTQGELVKAMKTVARLVTDPRLKQKLKDTTGIGTEATRANIISGLLSRGFLIRKGRAVRASDTAMMLIDAVPAAIADPGTTAIWEQALDMIEARQMGLESFVEKQAAWVTQLVRQHLGTTLAIRSPEGPPCPLCGAATRQRTGRSGPFWSCSRYPDCKGTAPVAPAQAGPDGQKRSRSRGARAQR
(1404) DNA topoisomerase 1 [Xanthomonas axonopodis pv. citri str. 306]
1
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNGFAMRYDLIEKNEKHVEAIARAAKGADDIFLATDPDREGEAISWHIAEILKERGLLKDKPMQRVVFTEITPRAIKEAMAKPRMIAGDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFIPREYWSIDAHCRHPSQAFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQAAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDEGSVGLISYMRTDSVNLSQDALAEIRDVIARDFGTASLPDQPNAYTTKSKNAQEAHEAVRPTSALRTPAQVARFLSEDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTTVVVPGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNVPLDRIVTDQHFTQPPPRFTEAALVKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDFTANLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGTDPVSGKEVSARIGRFGPMVQIGTVEDEDKPTFASLRPGQSIYSISLEDALELFKMPRALGQDKDQDVSVGIGRFGPFARRGSTYASLKKEDDPYTIDLARAIFLIEEKEEIARNRVIKEFDGSDIQVLNGRFGPYISDGKLNGKIPKDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNTVKDSAPKKPAVKKTATKTAASKTAVKKAPAKKTATKKAAKRVVKKTVSKAAG
(424) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1382) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(110) DNA topoisomerase 3 [Serratia proteamaculans 568]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGNNDVVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNAIKKLLHEADEVVHAGDPDREGQLLVDEVLDYLALSPEKRHSVRRCLINDLNPQAVERAIERLRDNRDFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVSKDFFEVKAHIVTPKDERFVALWQPSDSCEPYQDEEGRLLHRSLAEHVLKRIEGQPALVTSYNDKRESDTAPLPFSLSTLQIEASKRFNLSAQQVLDVCQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISVHQPDLYPQPVIDSDRRNRCWDDKKVDAHHAIIPTARASKVSLSQDELNVYGLVARQYLMQFCPDAMFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKDDQLLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIELLFKRAFLYKKGRYIHSSETGRALIHSLPDIAARPDMTANWEATLTQISEKSCRYQDFMQPLVGTLQELIYQAKQSRASMAFRGLPPSPSGGAKKRKKSAGKAREKSE
(93) DNA topoisomerase 1 [Serratia proteamaculans 568]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTEDKAKKKVKKDPTTALVNRMGVDPYHGWKAHYEILPGKEKVVAELKSLAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQNAFKQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKGDTALQMEVTHAHDKPFKPVNREQTHAALNVLEKARYTVLDREDKPTSSKPGAPYITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALEMVRGYIGDNFGDKYLPKAPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLSVKAADYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPYVEVGSDLELQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEENFRELMNYDFTARMENGLDQVANNQAEWKAVLDEFFAEFSEQLETAEKEPEEGGMRPNQMVMTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPETEVLNILEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEEGEFRLKGYDGPVVECDKCGSEMHLKMGRFGKYMGCTNESCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADAEGNKTLVRFSRKTKQQYVSAEKDGKATGWSAFYIDGKWVEGKK
(1256) DNA topoisomerase [Serratia proteamaculans 568]
4
MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPWRESVLPIVPTQWKMTVKKETADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHFTGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAREQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRATLQKGGIAFPASWVPAANYCDEEKRCIQQNVAQAVVQLCQQTGHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMSANQALSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTQSGSVARLDRTFVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEATFNIGGQLFRTRGKVEVVAGWKVLFQHDVSEAKEESTDTDDVRLPALVKGETVAVAGAELKTLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYLEKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGHLVEKGKAQAVKFTAPPSPPCPTCSGTMRRRAGKKGSGAFWGCSNYPTCQGIINIDAKGGRKAKRYKAKSPAKNKTTKSE
(1882) DNA topoisomerase [Serratia proteamaculans 568]
4
MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPWRESVLPIVPTQWKMAVKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHFTGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAREQGYGEVLSIGRVQTPTLALVVNRDRDITNFISKPYWQVRATLQKGGITFPANWVPAANYCDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMSANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRAFVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQYLSLHEVDVTEATFNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELKTLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILDTLFKRGYLEKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGHLVEKGKTQAVKFTAPPSPPCPTCSGSMRRRAGKKGGGAFWGCSNYPTCQGVINIDAKGGRKAKRYKAKSPTKNKATGSE
(202) DNA topoisomerase 3 [Actinobacillus pleuropneumoniae serovar 5b str. L20]
10
MISEKRILRVFLAEKPSLARAIADVLPKPHTRGDGYIQCGENDTVTWCIGHLLEQAEPDIYDERFKMWRMEHLPIVPQQWKLVPKKETLKQLKAVEKLVKKADVLVNAGDPDREGQLLVDEVFSYLNVPPEKRNRIQRCLVSDLNPSAVKKAIDKLQNNRDFIPLATSALARARADWLYGINMTRAYTLQGRWAGYQGVLSVGRVQTPVLGLIVRRDLEIENFVPKDYFEVLAHIVVPETQERFTAQWQPSKACEDYQDEDGRVLSKSLAENVVKRITDQAALVTDYQDKIETETAPLPYSLSVLQIDAARRYGLSAQAVLDICQKLYETHKLITYPRSDNRYLPNEHYADRFKVMAAIAHHLDEYKEKPEAVNPEIRNRCWNDKKVEAHHAIIPTVRQGSVKLTENEKRIYQLIARQYLMQFCPDAEYRKGKIVLEIAGGTFNAQARNLIVAGWKALLGKEDSDEVLEPLLPVVKKGQQLHCEKGEIVSKKTQPPRHFTDASLLSAMTGIARFVQDKQLKKVLRETDGLGTEATRAGIIELLFKRGFLIKKGRNIHSTEAGRILISALPDEATQPDMTAHWEMQLTDISKKQASYQQFMQVLTSKLPELLHTERQKLQNLSRIQPPASYRKRSNFKKNLQTAEK
(1406) DNA topoisomerase 1 [Actinobacillus pleuropneumoniae serovar 5b str. L20]
9
MGKSLVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPKSGSESEKGEKAKPISTKGMTAEQKAKLKAEKDRAALVKRMGIDPYHDWKANYQILPDKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGDDERFSRVVFNEITRNAIQKAFEQPDHLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWEILANTLTAKGKLPLDLTGYKGKKFSAKNQKQADEAVKSLQGSEFIVSEIDKKPTSSKASPPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALAMARGYIENQFGAEYLPAKPNFYSSKEGAQEAHEAIRPSDVNVKMADLKGMEKDAERLYDLIWRRFLACQMTPARYDSTSLTVTAGDYELKAKGRVLRFDGWTKALPVQGKTAEDQVLPEVALNEKLALEEVLPSQHFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLDESFSDLMNYDFTANMEETLDQIAEGNKNWKEALNNFFKDFSEQLTKAELDELEGGMKPNSLVPTEIDCPTCARKMAIRTASTGVFLGCTGYALPPKERCKTTMNLIPESELLNVLDEESEAKALLARKRCPKCDSAMDSYVIDPQRKLHICGNNPNCDGYVLEQGSFKIKGYDGPIVECDKCGADMHLKLGRFGKYMGCTACDNTRKILKNGEVAPPREEPTHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELAQYRDRLPEKLQYLADAPQQDPEGNEAIIRFSRKEKRQYVTSEKDGKATKWIVDYLDGKWLERKK
(1391) DNA topoisomerase 1 [Haemophilus parasuis SH0165]
9
MGKSLVIVESPAKAKTINKYLGSDFVVKSSVGHIRDLPTSGAEKEEKTEKAKAVSTKGMTAEQKALVKSEKERTALVKRMGVDPYHDWNATYQILPGKEKVVSELKSLAKKADHIYLATDLDREGEAIAWHLREVIGGENERFSRVVFNEITKNAIKQAFEKPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEFWDILAKTSAKKGDLALELVQHKGKKFSVKNQKEAEQAVKSLQNSAFIVTEIDKKPTSSRAKAPFITSTLQQTASTRLGFSVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALTMARSYIEKQFGDRYLPEKPNFYASKEKAQEAHEAIRPSDVMVKMQDLSGMEKDAERLYDLIWRQFLACQMTPAEYDSTSLTVTAGDYELKTKGRVLRFDGWTKVLPIQGKTAEDQELPEVSLNETLKLNAVEPSQHFTKPPARYSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNEAFSDLMNYDFTANMEDTLDQIASGNSNWKVELNRFFADFSEKLTTAELDELEGGMRSNNLVATDIHCPTCQRQMAIRTASTGVFLGCTGYALSPKERCKTTINLIPEAELLNVLDEDSETNALMKRKRCPKCDTAMDSYVIDPQRKIHICGNNPNCDGYVIEEGSFKIKGYDGPIVECDKCGSDMHLKLGRFGKYMGCTNCDNTRKILKNGEVAPPREEPVAFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRAPKVAELALYRDRLPEKLQYLADAPQQDPEGNEAIIRFSRKEKRQYVTSEKNGKATKWIVDYLDGKWVERHR
(1495) DNA topoisomerase 3 [Haemophilus parasuis SH0165]
10
MRLFIAEKPSLGRAIADVLPKPHTRGDGFIQCGEDNVVTWCIGHLLEQAEPDAYDERFKMWRMEHLPIIPEQWKLIPKKETLKQFKVVERLIKQADILVNAGDPDREGQLLVDEVFGYLNLSPERKSQIQRCLISDLNPNAVKKAIEKLQFNRDFVPLATSALARARADWLYGINMTRAYTLQGRWAGYKGVLSVGRVQTPVLGLIVRRDLEIENFIPKDYFEVLANVVVPETQERFQAQWQPSKACEDYQDEDGRVLSRPLAENVVKRITDQAACVTEYQDKMESEAAPLPYSLSALQIDAARRFGLSAQDVLDVCQRLYETHKLITYPRSDNRYLPNEHFADRLKVMAAIAHHLPEYAQKPDAVDPNKKNRCWNDSKVEAHHAIIPTARQGRQVHLTQNEQWIYQLIARQYLMQFCPDAEYRKGKIVLNIAGGTFIAQARNLVVAGWKSLLGKEDNDEIVEPLLPVVKKDQQLWCESGEIISKKTQPPRHFTDATLLSAMTGIARFVQDKQLKKVLRETDGLGTEATRAGIIELLFKRGFLIKKGRNIHSTEAGRTLISALPDVATQPDMTAHWEMQLTDISKKQASYQQFMADLNQRLPSLLSSPNKQILQSLAKITPLTTSSKSRYTRKSTQNVEK
(1354) DNA topoisomerase 3 [Shewanella denitrificans OS217]
10
MRLYIAEKPSLGRAIADVLPKPHKKGDGFITAANGDCVSWCIGHLLEQAEPDAYDVAFKSWKLEHLPIIPTQWQLKPKSSTRSQLSVLKKLVKQATHLVNAGDPDREGQLLVDEVIAYLGVKGDKLNQVQRLLISDLNPQAVQRALNQLKSNRDFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDEEIEAFVPKPFYEVLAHLLTDKQQGFTAKWQPSAACEPYQDEEGRVLVKGLGQNVVERISGQPAQVTGLVAQDKRQAAPLPYSLSSLQIDAAKRFGLSAKEVLDTCQSLYERHKLITYPRSDSRHLPVEQFSLAPSVINAVIKGAPTLISHTDAPNPKLKSKAWDDSKVEAHHAIIPTEKIAHLSALSMNEARLYQHIARQYLAQFYPAYQYAETQVEVTIAGGIFTTKARQNKSLGWKSLFSNNNKIVEHNTENNQEGEPESQTLPALKKGQWLNCERGELLEKMTQAPKHFSDASLLSAMTGIGRFVTNVEIKKILKDTDGIGTEATRAGIIELLFKRGYLLRQGKSILATPVGRGLINSLPMSATTPDMTALWEASLDKISHKTMRYQAFMAPLIQQLSELIGQAASELPRALQGLASPSKGKGFPKKKSAYSTKSSGKYKAKNAKAGTVAKKKS
(58) DNA topoisomerase 1 [Shewanella denitrificans OS217]
9
METIFYLFETFGANKTMGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSDGSASTKTAAEVRKMSPEEKAKYKLIRDKQALVSRMGINPEKGWAAKYQILPGKEKVVKELKALAESADQIYLATDLDREGEAIAWHLQEIIGGDASRYQRVVFNEITKSAIQDAFSQPSSLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDINAELNTAASQVLKMQVAKYQGESFNPINKAQAEQAVERLTNASYSVSAREDKATSSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEAVENVREMIAADFGTKYLPADPIRYGSKEGAQEAHEAIRPSNVQVQSASLTDMERDAQRLYELIWRQFVACQMTPAQYDATRLTVKAGDYELKASGRTLRFDGWTRAQPPMGKKNEEDNTLPHVDKGESLTLNTLAPKQHFTKPPARYGEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFFAEKMGEIVSDRLVGSFKELMSYDFTASMEQTLDDVAQGKLEWKQVLDGFYGDFTKQLEKAELDPEDGGMHLNQMVLTEAISCPTCDRPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSDAEDAETDALRAKHRCGKCGTAMDSYLIDEKRKLHVCGNNPSCDGYEVEAGQFKIKGYEGPLIECDRCGNDMELKNGRFGKYFGCTNSECKNTRKLLRSGEAAPPKEDPIFLPELKCTKSDAHFVLRDGAAGIFMAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPVEDDDGNKAAVKFSRKTKEQYVATEVDGKATGWTAKYHGGKWLVEQTKKKAKS
(1805) DNA topoisomerase 1 [Shewanella violacea DSS12]
9
MGKSLVIVESPAKAKTINKYLGKDYIVKSSVGHVRDLPTSSSPDSKVATKTPAEVRKMAPEEKAIYKSKKAKQALVARMGVDPDNGWKAKYQILPGKEKVVKELQALAEKADKIYLATDLDREGEAIAWHLQEIIGGDESRYQRVVFNEITKTAIQEAFSKPAHLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVATRLVVEREGEIKAFVPEEFWDIHAQLNTQANDLLKMQVVKFQGKAFNPVNEQQTLEAVSALSQSSFVVAARDDRATQSKPSAPYITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALDNVREMIAKEFGDKYLPDEPIRYGSKDGAQEAHEAIRPSDVKVHAALMSDMERDAQRLYELIWRQFVSCQMTPAKYDATRLTVKSGEYELKATGRTLRFDGWTRVQTAIKKKNEEESTLPHIEQGDKLDLKELDPKQHFTKPPARYGEASLVKELEKRGIGRPSTYATIISTIQDRGYVRVENRRFYAEKMGEIVSESLVGSFKELMSYDFTAGMEQTLDDVAKGELKWKKVLDGFYKDLTKQIEQAELPPEEGGMRPNEMVPTDNIKCPTCERPMGIRTGTTGVFLGCSGYALPPKERCKTTMNLTPGEEAVSENSEDVETDALRAKHRCDICGTAMDSYLIDETRKLHVCGNNPICVGHEVELGQFKIKGYEGPIIECDRCSNDMELKNGRFGKYFGCTNSECKNTRKLLKSGEAAPPKEDPIHLPDVKCTKSDGYFVLRDGAAGIFMAASTFPKSRETRAPLVEELVKYRELLWPKYAYLADAPVKDDDGNKASVRFSRKTKEQYVATDVDGKATGWTSKFIDGKWVTEAKKKAKPKAKAATTTKAKAKPKAKAKPKKAEKTED
(604) DNA topoisomerase 3 [Shewanella violacea DSS12]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGHIMAANGDCVSWCIGHLLEQAEPDSYDAAYKSWKFEHLPIIPEKWKMKAKPKTRSQLTVLRGLVKKATQLVNAGDPDREGQLLVDEVISHLGVKGEKLNNTQRLLISDLNPQAVKRALGQMRSNREFIPLSTSALARSRADWLYGLNMTRAYTLQGRKVGYQGVLSVGRVQTPLLGLVVRRDEEIANFVSKSFYEVQANLNTEKNEAFRAKWQPSEACQPYMDEEGRVLSKGLAQNVVDRISDKPAQVTQVIAKDKQQNAPLPYSLSSLQIDAAKRYGMSAKEVLDTCQTLYERHKLITYPRSDSRYLPAEQFSQAPQVIGAVLSGAGELVENSDKPDPKIKSKAWNDSKVDAHHAIIPTEKRVNLSSLSAWERQIYLQVARQYLAQFYPPYLYSETEVHVLIEGGHFKTKAKQERAQGWKQLFTRNNTANTNSASTGKEDDDESQQKLPALKKGQSLHSGAGELIEKQTQPAKHFTDATLLGAMTGINRYVTDPEIRKILKDTDGLGTEATRAGIIELLFKRTFLSRQGKTIIATEVGRGLINSLPLSATTPDMTALWESNLDAISRKEAKYQSFMTPLIDSLSHLITQAGSQLPTALQGVKAPKSSFKKRRFTKKKSKS
(42) DNA topoisomerase 3 [Pseudoalteromonas sp. SM9913]
10
MKLYIAEKPSLGRAIADALPKPHKKHDGYIEVANGDCVSWCIGHLLEQAEPDDYDERFKKWQFEHLPIVPEHWQLKAKTKTRKQLTILKKLIKQATTLVHAGDPDREGQLLVDEVIEQTKISQTKKQSIQRLLISDLNLTAVKKSLNAMRANRDFIPLSVSALARSRADWLFGMNLTRAYTLAGQKAGFGNVLSVGRVQTPILGLVVNRDNEIANFVSKPFYEVLAHLVTPEQQSFTAKWIPSKACEPYQDEEGRVLNKALAENVTSRIANQPANVTALEQKQKKQTAPLPYNLSALQIDAAKAFGMPAQKVLDICQVLYERHKLITYPRSDNRYLPREHHQDAPAILKAIAVNGGQSVELVNEANAKQRSKCFNDAKVAAHHAIVPTAKQLKSVSLANDEAKIYQLISRHYLIQFYPDYIYNESKVEVTIAGGLFKASAKQDVSLGFKLLMGKSELKEEATLPYLEKGMALTCTKGEVVQKHTSPPAHFTDATLLAAMTGISRYVKDLQIKKILKETDGLGTEATRAGIIELLFKRRFLKREGKAIKATETGLALISVLPEGLSSPDLTAKWESSLGDIAQQAMSYQQFIQPLLADLTNFVSQAANCNSQAFALLPKTSPKKRFAKRTKKAPYKKSSYKKSPAVN
(1343) DNA topoisomerase 1 [Pseudoalteromonas sp. SM9913]
9
MGKSLVIVESPAKAKTINKYLGNDFIVKSSIGHVRDLPTSGSGKNKVPASKTPAEVRKMPPDEKAAYKQQRDYSNLVARMGIDPEKGWEPHYEVLPGKEKVVQELQKLAQNADQIYLATDLDREGEAIAWHLQEIIGGEPEKYKRVVFNEITKNAIQQAFETPGELNTDMVFAQQTRRFLDRVVGFMVSPLLWAKVARGLSAGRVQSVAVRLLVEREREIKAFIPEEFWDIHADVKNSESDLRLEVTKQADKPFKPVNEAQATAAVKSLENAEYKVVSVEEKPSKSRPSAPFITSTMQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKDAVEMCREYVTNEFGAKYLPADPINYSSKGNAQEAHEAIRPSSVSVLSGHVEGVDADAKKLYELIWRQFVACQMVPAEYDLTTLTVAANDFTLKAKGRVLRFDGWTKVQPAVRKKNEEDQSLPAVKQGEVLTLVELDPKQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFFAEKMGEIVTDRLVENFTDLMNFDFTAKMEGRLDDIAEGERVWTQVLDKFYADFSTQLNIAKGEPDEGGMRLNQMVETDIDCPTCGRKMGIRTASTGVFLGCTGYNLPPKERCTTTMNLVSGDEAVAADVEDVETETLMQMKRCPICETAMDSYLIDETRKLHVCGNNPACQGHVVEEGTFKIKGYDGPIIECDKCGADMELKSGRFGKYFGCNNDECKNTRKLLKNGEAAPPKEDPVHIPELECEKSEAYFVLRDGAAGIFLAANTFPKSRETRAPKVEELQRFRDRISPKFYYLADAPAKDPDGNLAVVRYSRKNKVQYVMTEVDGKATGWTAHYEGGKWVEEAKKKAAPKKKAAAKKAPAKSKAKAKPKKDDE
(108) DNA topoisomerase 1 [Pseudomonas entomophila L48]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKTAGEAPALSPKEKARRQLVARMGVDPEAGWKAKYEILPGKEKVIDELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSQPGDLDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFNPEEYWEVHADLGTAKNAKVRFEVAREKGEAFKPLNEAQAMAALEKLKASSYSVVKREDRPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSTDAVEMARSYIENEFGKQYLPDAPVVYGSKEGAQEAHEAIRPSDVNTHPTKLSGMERDAERLYELIWRQFLACQMPPAQYLSTSVTVAAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMAQGEALKLIQLDPSQHFTKPPARFTEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVTLHNRRFYSEKMGDIVTERLSESFANLMDYGFTAGMEENLDDVAQGERDWKNVLDEFYGDFSKKLLTAESAENGMRANQPTLTNIACKECGRPMMIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESLVLRGKHRCPICATAMDAYLLDEKRKLHICGNNPDCAGYEIEEGSYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNATCKNTRKLLKSGEAAPPKMDKVDMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVLEIVPHKHEIDPKYHFLCDAPQKDPDGRPAVIRYSRKTKEQYVQSEVDGKPTGWKAFFDGKAWKVEDKR
(1302) DNA topoisomerase [Pseudomonas entomophila L48]
4
MRLFLCEKPSQAKDIAKVLGAQRRGDGCWQGTDVCVTWCIGHLLETAPPDSYDERYKRWSLDDLPIIPEKWKMTVKPKTASQYKAVKRLLGEARELVIATDADREGEMIARELVEHCRYRGPIQRLWLSALDDASIRKALARLLPGQETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIDVQLESAGNVFNAQWRAPEDACDDQGRCLKQALAQQAAHDMQAAGSARVMKIATERVRETAPLPFDLGTLQEVCSKKLGLGAQETLDIAQALYETHKLITYPRSDSGYLPLSQHGEAPGILAALQRADASLAPLQPYLDPQRRSRAWNDQKVSAHHGIIPTAAASDPSRLPPKYKAVYTLIRARYLAQFLPNHEYDRTQADFDCAGHTLRAVGKQIIEPGWRRALPEALMPQKGREAPPAQVLPALREGQDCAVQGLQLKDLWTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKETTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQNGEMSLDEFVARQSAWMGKLVQRCSGMRLTITGPAAGKAAAPWKKKRKSSGKGKVAGSGGKAAAGKPRQPRRKTAT
(371) DNA topoisomerase [Marinomonas sp. MWYL1]
10
MILYIAEKPSLARAIAAALPTPQKKEEGCIWLPNGDCVSWCIGHLLEQAEPHQYNPAYKSWNLDHLPIIPTDWQWQEKANTKKQLGILKKLIKKATVLVHAGDPDREGQLLVDEVLHYTKVPAQKLKNTQRLLVNDLTPSAVKKALSNLRLNNEFAALSRSALGRARADWLFGLNLTRAYTIKGRQAGYQGVLSIGRVQTPVLGLVAARDKEREAFVPKDFYQVWASIQTSQGAIFQAKWLPSEACKPYMDEENRVLSLPLAQNVANRITNKPAVVVEANYKQKKQPAPLPYSLSALQIDAAKAFSLSAQQVLDTCQALYERHQIITYPRSDCRYLPTQQHKDASAIIAALARSGTDIQQGAENADASRKSKAWNDKQVTAHHAIIPTTQAHKAASLSKTEALVFNLIARQYLMQFYPEYDYLASYIKLEIEGGLFEAKGNTPLALGWKALLPNKNKSKDPEDENQNELPKLSKNEELCCIQGQVQEKVTTPPAAFTDATLLAAMTGISRFVTDKDIRAILKETDGLGTEATRANIIELLFKRGFLIRQGKQIHASQTGRAFIDCLPMQLVTPDMTAKWESALNSISLGETSYQEFMTNLEGNLNQLLSASRDMPTSALQNLPQPSKSPFAKRKGSTSKRTASTRKATGTKSNSTKTTSSNTRRRSKAPS
(583) DNA topoisomerase 1 [Marinomonas sp. MWYL1]
9
MGKSLVIVESPAKAKTINKYLGNDFIVKSSVGHIRDLPSGTTATSTPQERAKQAALTRKMSPEEKLEYKSSKARKQLISRMGVDPESNWKAHYEILPGKEKVVDELKRLAKNADTIYLATDLDREGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIKAAFETPSELDMDRVNAQQARRFLDRVVGFMVSPLLWSKVARGLSAGRVQSVAVRLIVEREKEIRAFVPDEFWELDAMLATPSKEVIKFEAAKYQDKEYRPVNKAQSDEHVARLNDAKYLVSSREDKPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSVDAVEALRGYILSKFGEAYLPAEPIRYSSKEGAQEAHEAIRPSDVNVRVDDLQGMEKDAHRLYDLIRSQFMACQMTPAEYTSTTITVTSGDYEFKAKGRILRFDGYTRAMQAVAKKGEDNILPDVGQGEYLTLKELLPEQHFTKPVARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGDIVTERLVDSFSSLMNFSFTAQMEEQLDDIAEGHKDWIKTLNAFYKDFSSVLAKAESPDGGMMPNEPTPTDVECPTCSRPMQIRTASTGVFMSCSGYALPPKERCKATINLTRGDEAIPVDDEEGESKALINKHRCKICGSAMDSYLMDEHRKLHVCGNNPACSGYEVETGAFKIKGYDGPTLECDKCGSEMQLKTGRFGKYFGCTNEGCKNTRKLLKNGEAAPPKMDPVPMPDLACQKVDDHYVLRDGATGLFLAASQFPRKRETRAPLVEELLPYMDQIDPKYHFFAKAPKKDSEGRPAIIRYSRKTKEQYVMTEEEGKPTGWKAFYVGSKWVIEEGKKK
(1215) DNA topoisomerase 1 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
1
MSKHLVIVESPAKAKTIQKYLGNDYDVLASYGHVRDLPARKGSVNPEKHFSMTYVPIEKNARHIDTIAKTLKKSDSLLLATDPDREGEAISWHIFELMKERNLLKDKSVHRIFFNEITKAAIQDAINHPRSISMDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIVEREEEIERFIAQEYWKIIAKCAHASTEFEARLTHYNEEKLQQFSVTQQEQAHEIKKQLIAQAQGFLTVAQIDKKQRKRKPSPPFITSTLQQEAARKLGFTARKTMMVAQQLYEGIDIGTGTVGLITYMRTDSVNLAKEAIDEIRDYITQRYKGDNCPNSPRIYKTKSKNAQEAHEAIRPTSIKRTPEMVQGSLTSDQLKLYSLIWKRTVASQMADAILDTVSVDFSCGKGNTFRANGSTIAFPGFLSVYEEGRDDSKDEDNEDKILPAFNVGEKIKVSDIETNQHFTEPPPRYSEATLVKALEEYDIGRPSTYASIIHTLQQREYVVVEKKRFLPTDVGRIVNRFLTNYFTRYVDYQFTAGLEDTLDAIARGEKDWIPVLEEFWQPFVQQIQNIDEQVQRKDVTTELLDEKCPKCQKPLSIRLGKRGRFIGCTGYPDCDYTQDISNPEGEKSEPEVVEGRSCPLCHGALHIKTGRYGKFIGCSNYPECKHMEPLEKPSDTGVTCPKCSQAKILQRKSRKGKIFYSCGNYPKCDYALWNEPLDLPCPKCAWPILTLKESKKFGRQILCPREGCDYSAKED
(458) DNA topoisomerase 1 [Halorhodospira halophila SL1]
1
MGKSLVIVESPAKARTINKYLGSDYEVMASYGHVRDLVPKEGAVDPSSGFAMKYAPIDKNQKHVDAIAKAARKADALYLATDPDREGEAISWHLVELLRDKGTLDDKPVYRVVFHEITKGAIQEAMNNPRDISEELVNAQQARRALDYLVGFNLSPLLWRKITSGLSAGRVQSPALRMICERETEIEQFEPQEYWSVEADAAKAQQPFMAKLSQLHGEKVRQFTITDETHAQEVDRTLREAARAQPDPARIGPTGDGETEVIGTLRVASVERKQRRRNPAAPFITSTLQQEASRKLGFTASRTMRIAQQLYEGIDVGEGSAVGLITYMRTDSVNLSGEAITEMRQAITDRYGADKLPGQAQVYKTRSKNAQEAHEAIRPTSASRHPDDVRAYLNEEQRKLYDLIWKRAVASQMKHATIHTVAVDLAADADARHLLRATGSTVADPGFMVVYREGNDEGKDDSGEKFLPELEEGEQVDLHAIRAEQHFTEPPPRYTEASLVRALEEYGIGRPSTYASIISTLQNRNYVEMDGKRFIPTDIGRTVNKFLTEHFDRYVDYDFTARLEDDLDAISRGEQDWVPVLEAFWEPFRERVEEKKNVSRQEAVQARELGTDPKTGKPVTVRIGRYGPFAQLGSRDDDEKPRFAGLRPGQSIDTITLDEALQLFKLPRDMGETDEGEDVQVSIGRFGPYVRYGKKFVSIPKDEDPYTITKERAHELVREKKQADANRIIHDFGDGIQILRGRYGPYITNGEKNAKVPKDREPDSLTHEECQDLIAKAPARKGRRGGAAKGGRGRSKATS
(373) DNA topoisomerase 1 [Allochromatium vinosum DSM 180]
1
MNLVIVESPAKAKTIKKYLGPSFEVVASYGHVRDLVPKEGAVDPDHGFAMKYQIIERNEKHVQSIAKKLKDCEALYLATDPDREGEAISWHLHELLKSRRQLGDKPVHRVVFNEITKRAVQDAIANPRQISYDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREAEIEAFVQREYWTIEADTAKDARPFVARLTTFAGEKVEQFTITDEARATEVKTALEQAAGGKLKVEQVERKQRKRQPAPPFITSTLQQEAARKLGFTAQRTMRVAQQLYEGVDVGSGAVGLITYMRTDSVNLAQEAIDEIRAYVVERYSEADLPDAPRLFKTKAKNAQEAHEAIRPTSIRREPAAVKAHLTVEQFRLYELIWKRTLACQMAHALINQVAVDLSAGAGNMLRATGSMVVDPGFMRVYLEGRDDAKGADDDEDRMLPEMKVGELVDLLAIRPEQHFTEPPPRYSEATLVKALEEFGIGRPSTYASIISTLQDREYVILDKKRFVPTDVGRVVNRFLTDYFTSYVDYDFTARLEDDLDAVSRGEGDWVPLLERFWRPFKDLVDHTQEHVKRSDVTQERIEETCPKCGGQLAIRLGRNGRFIGCTQYPECDYTRDLDPDKAEREAPEVVEGRSCPLCGSALEIKRGRYGKFIGCSAYPNCKHIEPLDKPEDTGVTCPKCNKGTLQKKKSRRGKEFYSCSTYPKCDYALWDEPLAEPCPSCGWPVLTLKITKTQGAAKICPQKECGYRAPVEDQEAER
(1598) DNA topoisomerase 3 [Vibrio splendidus LGP32]
10
MSRLIIAEKPSLGRAIAAALPNPQKKDQGFIKCGNGDVVTWCIGHLLEQVEPDAYDDRYKKWNLADLPIVPEQWQLRPRKTSSKQLTLIRKLLKDATQIVHAGDPDREGQLLVDEVIDYCKVSKAKKESMDRLLISDLNLPAVKRALSQMRSNRDFIPLSISALARSRADWLYGMNMTRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFIPKDYFTLHALIPYQNNGQSFDIRARWKPSEACKPWQDEEGRVLNRKLVENVANRIANQPATVTESEQKQSKQAAPLPYSLSALQIDASKRFGMSAQQVLDTCQSLYEKHKLITYPRSDSRYLPKDHYSQRESVVDAIANNAKELQSGAQGADLSLKSKAWNDSKVDAHHAIIPTPKKSAVNGLSANEMKIYQQIARQYLMQFYPPAVFADAKLVFDIAGGVFIAKGRQLINPGWKVLMGKTDTEEKGDGTDTVPPLDKGTVLTCREGIIGDKKTEPPKHFTEATLLQAMTGIARFVANKDLKAILKETDGLGTEATRAGILDTLFKRQLLTRQGKSIHSSPAGRGLINALPEDSTFPDMTAHWEHQLQGMAERNQAYQPFMQELESKIDGLMGKVKTGEVPESLRHLPKVERPAFKRRKGGGAKSYANKGTYAKKGTYAKKGTKS
(789) DNA topoisomerase 1 [Vibrio splendidus LGP32]
9
MGKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTAGQSTGQKAAAVSTKGMSPEDKARIKKEKDRKALIKKMGINPYQEWEANYQILPGKEKVVAELQKLAENADHVYLATDLDREGEAIAWHLREIIGGDETRYKRVVFNEITKNAIQQAFETPGELNIDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFIPEEFWDVHADTKTAEKTDFRLQVAQKDGVAFKPDNEAQTQAAVSVLEKAQYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVEAAREYIGSEFGAQYLPPKALVYGSKEGAQEAHEAIRPSSVDVKSEDLNGVDADAHKLYSLIWNQFVACQMTPAQYDSTTVSVKADEYTLKAKGRILKFDGWTRVQRPMGKNEDTILPAVQVGEKLDLIALDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVEQRRFYAEKMGEIVTDRLDGSFNDLMNYDFTARMEQKLDQIAEGEASWKGVLDNFFEDFTGDLEKADLDEDAGGMKPNHIVETDIECPTCSRKMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEDGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYVVEHGEFKVKGYDGPLVECDKCSSDMVLKNGRFGKYMDCTSEDCKNTRKILKNGEVAPPKEDPVHFPELPCENSDAYFVLRDGASGLFMAASNFPKSRETRAPLVEELVRFKDRISPKFQYLASAPVADPDGKPTVVRFSRKTKENYVRTEVDGKPSGWTALYIDGKWEVTDKRKKPKEK
(1104) DNA topoisomerase 3 [Vibrio furnissii NCTC 11218]
10
MTRLFIAEKPSLGRAIADALPKPHKKDQGFIRCANGDVVTWCIGHLLEQVEPDVYDERYKKWNLADLPIVPEQWQLRARKSASKQLSVVKKLLKEANHIVHAGDPDREGQLLVDEVIDYCKVAKSKKESMERLLISDLNLPAVKRALTSMRSNRDFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPRDYFTLDALIPYQDANGAFDIRARWKPSDACKPWQDEEGRVLNRKLVENVASRIAGQPAKVVESEQNQTKQSAPLPYSLSALQIDAAKRFNMSAQQVLDTCQSLYEKHKLITYPRSDCRYLPKEHFAQAPSVTAAIANNANELAGAVANADLSRKSKAWNDAKVDAHHAIIPTPKQASVNALSSYEMKVYQLIARQYLMQFYPPAVYAEAKLVFDIAGGTFVAKGRQLLSAGWKTLTGQKEEQEEGVDTVPPLPVGTVLTCREGEIKDRKTEPPRHFTEATLLQAMTGIARFVADKELKKILRDTDGLGTEATRAGILDTLFKRQLLIREGKLIKSSAAGRGLIHALPSDATYPDMTAHWEHQLQAMAERGQAYQPFMQALQQRIDQLMAQVKTGPVPESLRALPKVERPAFKRKRRTSSNRSQPKGKSRT
(341) DNA topoisomerase 1 [Vibrio furnissii NCTC 11218]
9
MEEKARLKKEKDKAALIKKMGVDPYHGWEANYQILPGKEKVVAELQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEERYKRVVFNEITKNAIQQAFQQPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDIHADTKTPSKEDFRLLVAQKDGVAFKPSNEAEAMAAMSVLQKAAYEVCKREDKPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVDAVRQYITSEFGEAYLPGKPNVYGSKEGAQEAHEAIRPSDVAVKADALEGMEADAHKLYALIWNQFVSCQMTPAKYDSTTVSVKAAEYTLKAKGRILKFDGWTRVQRPLGKNEDQILPAVEVGETLSLEKLDPKQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFEDLMNYDFTARMEQKLDQIAEGETSWKGVLDNFFEDFSHNLETAEQDEDHGGMKPNHIVMTNILCPTCSRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEDGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGYIVEQGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILRNGEVAPPKEDPVHFPELPCENSDAYFVLRDGASGLFLAASNFPKSRETRAPLVEELAKYKDRLPEKYQYLADAPAQDPDGLKAVVRFSRKSKEHYVRTETDGKPSGWTALYNDGHWDITDKRKKAK
(251) DNA topoisomerase 3 [Vibrio fischeri ES114]
10
MLFTTSAFFMSRLFIAEKPSLGRAIAAGLAKPQKNQQGYIECGNGDIVTWCIGHLLEQVEPDAYDDKYKSWRMEHLPIVPDQWQLRPRKASSKQLTVIRKLLKNATQIVHAGDPDREGQLLVDEVLDYLKLSKTKKAATQRLLISDLNLPAVKRALTSMRSNQEFIPLSISALARSRADWLYGMNMTRAYTLLGQRGGYQGVLSVGRVQTPVLGLVTRRDEEIANFVPKAYYTLDALIPYQNDQLNDGVPFDIRAKWKPSDACQPWQDEEGRVLNLKLVENVAQRIANQPATVTKAENKETKQNAPLPYSLSSLQIDAAKRYGLSAQQVLDACQALYEKHKLITYPRSDSRHLPKDHYKQREQVCAAIGNNDKQLSTAVTKADFSLKSRAWNDSKVDAHHAIIPTPKSSSSAGLSGYEEKVYHLIARQYLMQFYPAAVYAEAELVFDIAGGVFVAKGKQMLFAGWRVLLGKVQSQNSDDDVASKVPPLSKGEVHTCREGEIKHRMTEPPKHFTEATLLQAMTGIARFVEDKELKKILRDTDGLGTEATRAGILDTLFKRQLLTRNGKSIHASEAGRGLIHALPNEATYPDMTAHWEFQLQGMTEKTHAYRPFMSELEIKVTNFMQGVQQGPVPESLRTLKSPAKPQFKRKRKAKKS
(1523) DNA topoisomerase 1 [Vibrio fischeri ES114]
9
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPMGSTSTGKKAAASTKGLSVEEKARIKKERDKKNLINKMGIDPYNDWAANYQILPGKEKVVAELQKLAESADTVYLATDLDREGEAIAWHLREIIGGDDSRFKRVVFNEITKNAIQQAFETPGELSMPGVNAQQARRFLDRVVGFMASPLLWKKVARGLSAGRVQSVAVKVLVEREREINAFIPEEFWDIHADTLTADKENFRLQVAQRNGSAFKPLNQADTEAAVSILQNAEYEVCKREDRPTKSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEGGYITYMRTDSTNLSKEAVEALREFIGSEYGDSYLPAAPIVYGSKEGAQEAHEAIRPSSVEVKADDLQGMEADAHKLYNLIWNQFVACQMTPAQYDSTTLSVKADEFTLKAKGRILKFDGWTRVQRPMGKNEDQLLPAVQLGDKLKLEKLDPKQHFTKPPARFTEAALVKELEKKGIGRPSTYASIISTIQDRGYVRIDNRRFYAEKMGEIVTDRLNQSFDDLMDYDFTARMEGNLDRIAEGEKDWKDVLNTFFQDFTADIAKAELDESEGGMSPNNIVETDIKCPTCGRNMGIRTASTGVFLGCSGYALPPKERCKTTINLGSEEGIVNVLEEDVETAALRAKKRCPKCETAMDPYLIDQERKIHVCGNNPNCEGYVVEKGEFQLKGYDGPVVECDKCGSDMELKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHLPELVCEKSDAYFVLRDGASGLFLAASTFPKSRETRAPLVEELVRFKDRLSPKFLYLTEAPTHDPDGKPAVVRFSRKTKENYVRSEVDGKPTGWTGLYIDGKWAITDKRKKPKAEK
(1225) DNA topoisomerase [Chromohalobacter salexigens DSM 3043]
3
MRLIIAEKPSLARAIADALPTAPQRHEGYLVCGETCISWCVGHLLEQAPPDAYDARYQQWRLDHLPIVPRQWKLIPRSKARAQLAVIRKLLKRADTVVHAGDPDREGQLLVQQVIAHLGWRGSISRLLVSDLNRPAVRQALQCIEDNARYQSLFEAAEARSRADWVYGINLSRAWTLTGRQAGYQGVLSVGRVQTPVLGLIVRRDLDIEAFTPRPFYPLWADLKVEHGTLRAWWQPQAPHPLDEQGRLLERAPAEALAAHLPGAEGHLSELQSKRQTQSAPLPYSLSALQVDAARRYKLPAKRVLDICQTLYERHQLITYPRSDCRYLPEGHFAAAKKTLDTACAQDATLRGWYQGADFSRRSRAWNDKQVGAHHALAPTGRTFDASRLTGDEANVFRLIARNVLAQFYSPLVTRDVKAAFSIHGEHFRAQGREILEPGWKPLFTTRDEAPPLPALHEGEAARVVDCAVEDRQTRPPDPFTDASLIKAMMNIARYVDDATVKRTLRDTDGLGTEATRAGIMETLVTRGYIVRQQGALRATRTGRALIQALPDTATRPERTALWEQRLADIAEGRGDADAFLDALVGDVRQLLDQADAARMRQALATTGGAEPSSPSRGKKRGTRRGSGDASSSPRRRAGKSTARRRTSSKKGQT
(607) DNA topoisomerase 1 [Chromohalobacter salexigens DSM 3043]
9
MGKSLVIVESPAKAKTINKYLGNDFVVKSSVGHIRDLPTSGSGKNATDPKERARQAAATRKMSPDEKAVYKKQKHWNQLVRRMGIDPEHGWEANYEVLPGKEKVVAELKKLAEKADAVYLATDLDREGEAIAWHLQETIGGDASRYRRVVFNEITKNAIQEAFKTPGDLDLSRVEAQQARRFLDRVVGFMLSPLLWSKIARGLSAGRVQSVAVRLIVEREREIRAFVPEEFWDVHADLLPASGEDTPIRFEVARHQGKAFRPTSEQETLERIAPLRDAALTITERETKPTRSKPNAPFITSTLQQAASGRLGFSVKKTMTLAQRLYEAGYITYMRTDSTNLSQDAVESARAFIGERFGQSYLPDAPNRYASKDGAQEAHEAIRPTEVTQAGDDLAVERDAQRLYELIWRQFVACQMVPAEYLATTLTIEAEGFELKARGRVLKFDGYTRVMKPAGKKEEDQSLPDLEEGAEMTLQALDPQQHFTKPAPRYTEASLVKELEKRGIGRPSTYASIISTIQDRGYVKLENRRFYAEKLGDIVTDRLAESFSDLMDYGFTARMEDHLDEIAAGNREWRELLDAFYAEFKAKLEHAEAEEGMRPNQPVPTDIDCPTCGRKMQIRTASTGVFLGCSGYNLPPKERCKTTIDLIAGDEAVAADADEEAETEALRAKRRCPECGTAMDSYLIDETRKLHICGNSPDCSGYEIEQGKFRIKGYDGPTIECDKCGSEMQLKSGRFGKYFGCTNENCKNTRKLLRNGEVAPPKMDPIPMPELACQKVEDHYVLRDGASGLFLAASQFPKNRETRAPLVKELKAHRDELPEKYHFLLDAPSEDPDGRDAQIRFSRKTKRQYVMSERDGKASGWRAEYEDGQWRVEDKRK
(1738) DNA topoisomerase [Marinomonas mediterranea MMB-1]
10
MILYIAEKPSLARAIAAALPSPQKKEDGCIWLPNGDCISWCIGHLLEQAEPHIYNPAYKSWSLDHLPIIPDDWQWQEKSQTKKQLSKLKKLIKQADQLVHAGDPDREGQLLVDEVLHYTNVPKKKLETTKRLLVSDLTPSSIKKSLGKLKLNSEYSALSRSALARARADWIYGLNLTRAYTIKGRQAGYQGVLSIGRVQTPILGLVVKRDLEIENFVTKDYFQVHAHLATEANEHFVANWVPSDACKPHMDEDGRVINRALAENVARRITHKPGTVVKAEYNTKRQSPPLPYSLSSLQIDAAKRWGLSAKQVLDTCQDLYEKHQMISYPRSDCRYLPVEQMSEISSIIKVLKSTSSEINNWCENANPHLKSSAWNDKKVGAHHAIIPTQKSGKYASLSHREKQVYELVVRQYLMQFYPNYEYLAAKIVAEIEGGTFSATGNTPLTLGWKSLLGATLNNDDKKTEETEPNLPKLTQGDPLFCRLGEVVQKQTKPPAHFTDATLLAAMTGIAKYVEDKSVKDILKETDGLGTEATRASIIELLFKRQFLFRDSKKIKATEAGRLFVSCLPRSTITPDMTAVWESTLSAISVKQASYEAFMTSLEATLTHLLNEARNTPLTSLTSLAKSTPAKTAWKARRSSSSRSSTKKEPTKRGSKGTGQKTTYKKKTTYKKSN
(1076) DNA topoisomerase 1 [Marinomonas mediterranea MMB-1]
9
MGKSLVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTGTTSKSTPQERAKQAALTRKMSPEEKAEYKSKKSRQQLIARMGVDPENNWEAHYEVLPGKEKVVDELKRLAKNADTIYLATDLDREGEAIAWHLREAIGGDEARYKRVVFNEITKNAIKSAFDEPSDLDMNRVNAQQARRFLDRVVGFMVSPLLWSKVARGLSAGRVQSVAVRLIVEREKDIRAFNPEEFWELDALLATASKEQVKFETLKYLGKEYRPTSQIESDEHVARIQNSGFVVSNREDKPTRSKPSAPFITSTLQQAASTRLSFGVKKTMMLAQRLYEGGYITYMRTDSTNLSNEAVEALRDFVGEKYGEAYLPKEPIRYSSKEGAQEAHEAIRPSDVTVTQNMLQGMDNDAHRLYELIRNQFIACQMTPAEYTSTSITVTAGDYELKARGRILRFDGYTRVLTPVGKKAEDMILPDIQKGDTLGLNELLPEQHFTRPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVDNRRFYAEKMGDIVTERLVGSFSQLMNFSFTAQMEEQLDEIAQGEDDWIRTLDAFYADFSNTLTKAEHPEEGMLQNQPTPTDVECPKCGRPMQIRTAATGVFLSCSGYALPPKERCKATINLVSGDEAVAVDDDEGESKALINKKRCKICDSAMDSYLMDETRKLHVCGNNPSCSGYEVEKGAFKIKGYDGPVIECDKCSSEMQLKTGRFGKYFGCTNEECKNTRKLLKNGEAAPPKMDPVAMPDLACQKVEDHYVLRDGATGLFLAASQFPRKRETRAPLVSELIPYMDQIDPKYHFFSDAPVMDNEGRPTVIRYSRKTKEQYVMTEENGKPTGWKAFHQNGKWVVEEGKKKK
(512) DNA topoisomerase 1 [Psychrobacter arcticus 273-4]
9
MTKPTTKKSAAPAADKPKGSPKGKSLVIVESPAKAKTINKYLGDDFIVRSSIGHVRDLPVGASKSAKKPATTKKDDILTKEEKTQQALVRRMGIDPEHDWAAVYEVLPNKTKVIKELKALAKDADKIYLATDMDREGEAIAWHLKEVIGGADSKYERVVFNEITKSAIQNAFKQPSKLDIDRVNAQQARRFLDRVVGFMVSPLLWQKVARGLSAGRVQSVAMRLVVEREHEIRAFIPEEYWQIHADTHIVDNKDKKATDAEQIGIRLEATKQGGKTLKLVNKEQTDKVLDVLKANDFIVKEREEKPTQSRPSAPFITSTLQQAASTRLGFSVKKTMILAQRLYEAGHITYMRTDSTFLSGDALAAVRGYIEDSYGAKYVPEKPTFYGNKQGAQEAHEAIRPSNVNMKSTQLKAVERDAIRLYELIWRQFVACQMLPAKYLSVNLFVAADDVELKARGRTLVFDGYTKVMPPAKTDDNLLPDVKKGDKLTVDKLDPSQHFTKPPPRYTEASLVKELEKKGIGRPSTYASIISTIQDRGYVKLENKRLFAEKMGDIVTDRLTASFPDLMDYTFTAALEDKLDHVAEGDTNWKDVLDNFYGDFKTTLDRAKEKDGMRPNDPTDVPDVHCDLCDRPMQLRTGSTGVFLGCTGYNLPPKERCKGTKNLMPVEAFANLDDAEGDDEAAEVRDLMEKKRCPKCSTAMNGYIVDGGLKLHVCGNNPDCDGYVLEEGKFEVPGSDSPTIDCNKCDGQMELKTGRFGPYFACQQCDNTRKVLKTGEAAPPRMDPIHLPELKSVKHEDYFILREGAAGMFLAASKFPKVRETRPPKLAELREIKDKMEDKFQYLFEGPDEDPDGNPTILRWSRKKKEQYIGSEKNGKATRWGVYWRKGEWVEE
(59) DNA topoisomerase [Azotobacter vinelandii DJ]
4
MATMRLFLCEKPSQAKDIAKVLQATRRGDGCWLGPDLAVTWCIGHLLETAPPDAYDARYKRWDLSDLPIVPEHWKMLVKPKTASQYKVIKRLLGECRELIIATDADREGEMIARELVEHCRYRGPIRRLWLSALDDASIRKALAALKPGTETFSLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLSVGRVQTPTLRLVVDRDRSIADFVPVPWWAIEVQLLAEGTPFTAQWRAPEDACDDQGRCLKQELAQQAAQDMRHAGSARLVALKTERIREMPPLPFDLGTLQEICSKKLGLGAQETLDIAQALYETHKVITYPRSDCGYLPQSQHGEAPAILAALERTDPALAGLMHHIDPRRRSRAWNDARVGAHHGIIPTAAAQSLDRLVGKQCAVYTLIRARYLAQFLPNHEYDRTQADFDCAGHALRAVGKRIVEPGWRRALPEALTPAKGRETPPSQELPALREGQDCAVAEVTLKDLWTQPPKPYTEGDLIKAMKNVAKLVDDPRLKQKLKDTTGIGTEATRAGIIQALIERGYLLKQGKALAATPAAFSLIDAVPRPIADPGTTAIWEQALDMVQSGEMSLEAFVAKQSAWMSKLIERCAGLRLTISGPAAPVGRGAGPWKKKRKAGKPGAGGRRRARPAAPP
(413) DNA topoisomerase 1 [Azotobacter vinelandii DJ]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGSASTAKEPAKRGKGVAEGPALSPRDKAKRQLFARMGVDPEHGWQAHYEILPGKEKVVDELRRLAREADTIYLATDLDREGEAIAWHLRESIGGDEERYKRVVFNEITKKAIQEAFSQPGDLDINRVNAQQARRFLDRVVGYMVSPLLWQKIARGLSAGRVQSVAVKLIVEREREIRAFIPEEFWEVHADLGTARGDKVRFEVAREQGEVFRPLNEAQAMAALEKLKASSYQVLKREDKPTRSKPSAPFITSTLQQAASNRLGFSVKKTMMMAQRLYEAGYITYMRTDSTNLSADALEMARGFIDSEFGGKYLPAKPNVYTSKEGAQEAHEAIRPSDVNLRPNQLAGMERDAERLYELIWRQFVACQMPPAEYLSTNVSVQAGDFELRAKGRILKFDGYTRVLPQLAKPGEDDVLPEMSEGELLDLLKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQERGYVTLQNRRFHSEKMGEIVTERLGESFANLMDYGFTASMEEHLDDVAQGERDWKNLLDEFYGDFRRKLEAAESSEAGMRANQPTLTDIPCRECGRPMMIRTASTGVFLGCSGYNLPPKERCKATVNLIPGDEIAADDEGESESLLLRHKRRCPKCGTAMDAYLLDERHKLHICGNNPDCPGYEIEEGQYRIKGYEGPTLECDKCGSEMQLKTGRFGKFFGCTNAACKNTRKLLKNGEPAPPKMDAVKMPELRCEKVDDVYVLRDGASGLFLAASQFPKNRETRAPLVLELLPHRDEIDPKYHFLLEAPSHDPEGRPAVIRFSRKTKEQYVQSEVEGKPSGWRAFHRDGRWVVEDKH
(474) DNA topoisomerase [Pseudomonas putida S16]
4
MRLFLCEKPSQAKDIAKVLGANRKGDGCWQGTDVCVTWCIGHLLETAPPDSYDERYKRWNLADLPIIPEKWKMLVKPKTASQFKAVKRLLGEARELVIATDADREGEMIARELVEHCRYRGPVQRLWLSALDDASIRKALARLLPGHETFNLYHSALGRSRADWLIGMNMSRLFTLLGRQSGYQGVLPVGRVQTPTLRLVVDRDRGIADFVPVPFWAIDVQLEHAGFGFNAQWRAPDDACDDQGRCLNQALAQQAAVDIGNAGTARAVKVTTERVREAAPLPFDLGTLQELCSKKFGLGAQETLDIAQALYETHKLITYPRSDCGYLPQSQHAEAPAILAALQRSDASLAPLQPYLEPQRRSRAWNDAKVSAHHGIIPTAAASDPSRLPAKHKAVYTLIRARYLAQFLPNHEYDRTQADFDCAGHALRAVGKQIVEPGWRRALPEALTPAKGREAPPAQVLPALREGQDCTVQGLQLKDLWTQPPKPFTEGDLIKAMKNVAKLVDDPRLKQKLKETTGIGTEATRASIIQGLLDRGYLVKNGKALSATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMTLEEFVARQSAWMGKLVERCSGMRMTISGPAAGAAPPWKKKRRGGGKGKAAAGKPRQPRKKATT
(603) DNA topoisomerase 1 [Pseudomonas putida S16]
9
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKAAGEAPALSPKEKARRQLVARMGVDPDHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDLDREGEAIAWHLREAIGGDDTRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEIHADLGTAKNAKVRFEVAREKGEAFKPLNEAQAMAALEKLKASSYSVVKREDRPTSSKPSAPFITSTLQQAASNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADALDMARSYIEREFGKQYLPEAPLVYGSKEGAQEAHEAIRPSDVNTHPSKLSGMERDAERLYELIWRQFLACQMPPAQYLSTSVTVAAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLPEMVQGEALKLIQIDPSQHFTKPPARFTEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVTLHNRRFYSEKMGDIVTERLSESFSNLMDYGFTADMEENLDDVAQGERDWKNVLDEFYGDFSKKLQTAESNEDGMRANQPTMTNIPCKECGRPMMIRTASTGVFLGCSGYSLPPKERCKATVNLVPGDEIAADDEGESESRVLLGKHRCPICATAMDAYLLDEKHKLHICGNNPDCAGYEIEEGNYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTNPACKNTRKLLKSGEAAPPKMDKVDMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVLEIVPHKHEIDPKYHFLCDAPQKDPEGRPAVIRYSRKTKEQYVQSEVDGKPTGWKAFYDGNAWKVEDKR
(275) DNA topoisomerase [Pseudomonas putida S16]
4
MRLYICEKPSQARDIARVLQAHRRGDGYLQGIGVTVTWCVGHLLETAPPETYSDQFKRWSLEHLPIIPQHWQLVVKPKVAAQLKAISRLLQACAEVVIATDADREGEMIAREILERCQYQGPILRLWLSALDDASIRRALTALRPGEQTLPLYHCALARSRADWLVGINLSRLFTLLGRRAGFDGTLPVGRVQTPTLRLVVERDRAIASFVARPFWTVDVVLHADGAEFEARWQPPAAHCDDAGHCVDQAAAEQVARRLAAARSVQVERVDVERVTEGPPLPFDLGTLQEVCSAKLGLGAQETLSVAQALYETHKATTYPRSDCGYLPESMLDEVPRVLKALAAADPALAQRFKEFDPTRRSRAWNSSKVTAHHGIIPTPVVIPLDQLSERERAVYTLIRARYLAQFLPHHEYLKTQVQLRSQADQVLARGKQIQVRGWKAVIDETDASEPTEQTQRLPTLQDGASVAAHDATINTQRTQPPKPYTEGTLVKAMKTIANQVADMRLKQTLKDSIGIGTEATRAAIIQGLIDHGYLTKKKRSLAASAAAHTLIEAVPREVADPVMTALWEQALARIETGQLSVEAFLAKQSAWLTQVVRSQASLNLQLPRSKGPACPVCRSPMRQRKGRTGNFWSCVRYPDCKGTKPVKASAAPAKPKRS
(1573) DNA topoisomerase 3 [Pectobacterium atrosepticum SCRI1043]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGQNDVVTWCVGHLLEQAQPDVYDARYARWSLADLPIIPQKWLLQPRPSVSKQLSAIKKLLNDASEVIHAGDPDREGQLLVDEVLDYLSLPEEKRQQVRRCLINDLNPQAVERAVSRLRENREFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVSKDYFEVKAHIVTPADERFVAIWQPSESCEPYQDEEGRLLHRSLADHVVKRIDGQPAFVTSYNDKRESETAPLPYSLSTLQIEAAKRFGLSAQQVLDVCQKLYETHKLITYPRSDSRYLPEEHFTGRHAVLNAIAVHQPDLLPQPVMDIDRRNRCWDDGKVDAHHAIIPTARSASASLTENERKVYGLVARQYIMQFCPDAVFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGGKERNEENEGMPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRTFLFKKARYIHASEAGRALIHSLPASAAHPDMTAHWEATLTQISEKKCRYQDFMQPLTNSLQELIQQAKQNGAVRAFKGFSAPPSGASKRRKPQAKKAKEQDQ
(380) DNA topoisomerase [Pectobacterium atrosepticum SCRI1043]
7
MMRLFLCEKPSQGRDIARFIGATQRGKGFLSGTGTVVTWAFGHLLEVASPEEYGAQFGKPWRMDVLPILPTEWKMVVKQSSADQFAVISRLLKQADEVVIATDADREGEVLARELLDYCHFTGNVKRLWLSALDDASIRKGLDNLLPGEKTVRLYYAGMGRSKADWLIGMNLTRIYTLKASEQGIDELLSIGRVQTPTLALVVQRDSDIENFSPKPYWQVFADIEKAGMTFRAQWVPAAGYCDDEKRCIQHNAALAVEQLCKQTATTSVVDVLLKREKTPAPLCFSLSVLQKACSDKWGMIAQKVLEIAQSLYEVHKATTYPRTDCGYLPESMKGEVSDVLSAILQSDPAATSLIKDADRSFVSRIWNDKKISAHHAIIPTKQPFDISKLSDDELNVYQLIRLHYFAQFFPLHESDVTDVTFNLGGQLFKTRGRVSVVIGWKKLFFNDKEPDIQSDENGSQGSLPVLHNGDICNVLDCEVKAQQTKPPSRFTDGTLIDAMKNSASFISDPTLKKILRDNAGLGTEATRANILDVLFKRNYLKRREKFIYSTQLARELISQLPEALTNPGMTALWEQALDDVAEGRMSLDAFLQKQKEWTLRLVDRGRQQAIKLTAPVSPLCPQCGGIMRKRNSDNGVFWGCVKYPLCKGIISEGTKGKRGKKNLKTKNKPAT
(835) DNA topoisomerase 1 [Pectobacterium atrosepticum SCRI1043]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSVSKKSADSTTKDKTKKKVKKDEKSALVNRMGVDPYHGWEANYEILPGKEKVVSELKALAENADHIYLATDLDREGEAIAWHLREIIGGDDQRFSRVVFNEITKNAITQAFEKPDTLNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVDREREIKAFVPEEYWELHADLLAGSDIQLQMQVTHHNGKPFKPVNKEQTHAAVSLLENARYVVADREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALTMVRGYIGEEFGKRYLPEAATGYSNKENSQEAHEAIRPSDVGVLADSLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLIVEAADYQLRAKGRTLRFDGWTKVMPALRKNDEDRTLPTVAVGEGLSLQKLLPGQHFTKPPARYSDASLVKELEKRGIGRPSTYASIISTIQDRGYVRAENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESRLDQVANNQAEWKAVLDEFFNEFSQQLEKAEQDPEEGGMRPNAMVLTSIDCPTCSRQMGIRTASTGVFLGCSGYALPPKERCKTTINLIPETEVLNVLEGDEAETNALRARRRCEKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEAGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTGETCSNTRKILRNGDVAPPKEDPVPLPELSCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELDRFKDRLPEKLRYLADAPVADKDGNKTQVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEGKK
(317) DNA topoisomerase 1 [Sodalis glossinidius str. 'morsitans']
9
MGKALVIVESPAKAKTINKYLGKDYVVKSSVGHIRDLPTSGSASQKSTDASKKKKGKPDAQLALVNRMGIDPYHGWKARYEILPGKEKVVTELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITRNAITQAFEQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELHADLKTAQAAPLAMQVTHQREKPFKPVNQQQIQAALDGLENADYVVSDRDDKPTSSKPGAPFTTSTLQQAASTRLGYGVKKTMTLAQRLYEAGHITYMRTDSTNLSQDALNMARGYISASFGSPYLPKQANDYASKNNAQEAHEAIRPSDVNALAEQLKDMEADVQKLYQLIWRQFVACQMTPAQYDSTTLTVTAGEFQLRARGRTLRFDGWTKVMPALRKGDEDRTLPAVEAGQTLTLIKLLPSQHFTKPPARYSEASLVKELEKRGIGRPSTYVSIISTIQDRGYVHAENRRFYAEKMGEIVTDRLEENFRELMNYNFTAKMEDTLDQVAANQQEWKQVLDAFFQEFSQQLENAEKDPEDGGMRPNQMVMASINCPVCGRKMGIRTASTGVFLGCSGYALPPKERCKNTINLIPESETLNVLEGDDAETNALRARRRCGKCGTAMDSYVIDGQRKLHVCGNNPLCDGYDIEQGEFRIKGYDGPVVECEKCGADMHLKLGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELLCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVAELARFRDRLPENLRYLADAPVKDDEGDSTLVRFSRKTKQQYVSSEKDGKATGWTAFYIDGEWQVTKK
(649) DNA topoisomerase 3 [Sodalis glossinidius str. 'morsitans']
10
MQLFIAEKPSLARAIADVLPKPHRRGDGYIACGPDHVVTWCIGHLLEQAQPDVYDGRYARWSLADLPIIPEKWRLQPRPSVQKQLDVIKTLLAKAERVIHAGDPDREGQLLVDEVLDYLALDEAKRRDAKRCLVNDLNPQAVSKAVSRLRENSEFVPLCVSALARARADWLYGINMTRAYTLIGLNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPKAYFEVKAHIVTPSQERFIALWVPSDACESWQDEEGRLLHRPLAEHVVARITSQPAYVMLYQDKRESEAAPLPFSLSALQIEAAKRFGLSAQQVLDTCQRLYETHKLITYPRSDCRYLSEEHFAGRQAVLAAIAAHQPALMTQGQLNTDQRNRCWNDKKVDAHHAIIPTARTSRATLNDSEQKIYALVARQYLMQFCADAVFRRCIIELDIAGGKFFVRARFLAEAGWRALLGAKERDEEDEGTPLPVVAKGDALLCECGEVVARETQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIELLFKRGFLFKQGRYIHASETGRGLIHALPPSAASPDMTAQWEASLTQISEKQCRYQDFMQPLTHTLQQLIEQARQQPAPSSLRGLPPASEKPALKQARRKRKPP
(73) DNA topoisomerase [Acidithiobacillus caldus SM-1]
3
MSTVVIAEKPSMARAIQEGLGQQANRYEITNAFGHILEQAEPDAYLPGDVPKTAKGKKIWRMQDLPILPAEWKKFPKRDAKDQLAKIGALLKSADTVINAGDPDREGQLLIDEILEHFHYRGKVLRVWLKALDAENVRKAFAALESNEKYRPLKDAAEARSQSDWVVGMNLTRAVTVKSGDLFSIGRVQTPTLAIVVRRDLEIENFVPKDYFEVFAQCRHAQGAFLAKWEPSSTDGPGFDEEGRLIDKRLAEAIAQKAKGAGKVARFEAKEQKQSAPLPYSLSALQKVASSRFGMSAQQVLDTCQSLYEKKITSYPRTDCRYLPEEQLVDAPRILGKLPIPDGIRPLLNPRQKHVAWNNAKITAHNAIVPTGEPARGLSDAEAKLYDLIWKSYVALFLPDYRYRALSATIALGGESWKATGRQDIDLGWKKLFGAQALEDDEDADAARAPLPVMQTGDPVQGDGGKVEARQTKPPARFTDGSLIDAMSNIHKFVTDPQAKAKLKETSGLGTEATRASVLETLLQREYLQKKGKQLISTPKGRALIAYLEKQRLGSFADPVTTARWEDVLGMVAEGKVPMQKFTTAVTQEVAKAIEVLKSGSAMAGGGNATQQPLRAQPCPICGGDAVVRRLQSKKNRKVFFWSCSNRDAHPLLQDDNGKPGKPFEERKEDSGPPGPACPHCAGTATRTKTTSTGKTYYRCPSCQAAFWPDREDPQRLGAPWPPAENGGRRGSGATRSSSAKRSSGGDPSAPKTRSSTGGKKSASSGARGGKGRKSG
(1861) DNA topoisomerase 1 [Acidithiobacillus caldus SM-1]
1
MGQQLVVVESPAKAKTIEKYLGKDFTVLASYGHVRDLLPKEGAVDTEHGFAMRYAEIERNRRHVDAIAKALRSADALWLATDPDREGEAISWHLVELLREKGLLKDRAVHRVVFHEITQKAVREAIAHPREIAGDLVNAQQARRALDYLVGFNLSPLLWRKVRPGLSAGRVQSAALRLVCEREDEIEAFVRQEYWTIGAHLRRGEDPFTARLTHWQQQKLEQFDIVDGERAEEIRQAILADIAAGGLRVRKVERKNRQRQPAAPFTTSTLQQEASRKLGFSASRTMRVAQQLYEGVSIGTETVGLITYMRTDAVNLAEEALTSLRSFILGHYGADFLPAEARRYQTKSKNAQEAHEAIRPTDVQRTPEKLRGVLERDLWRLYDLIWKRAVACQMAAARLDLVAADLDADSHWTLRANGSTVTFPGFMAVYLEGRDEAAEEDEERLLPPLREGESVAVDAVLGEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVEVQQRRFVPTDLGRVVGRFLIQHFERYVDYGFTAAMEDELDAIARGEKQWQPVLAQFWGPFHELLEEKANVSRQEATSEALDEDCPECGKKLLVKLGRHGRFIACSGFPECHYARPLDGPRDAPEPVGRDCPDCGQPLVYKTGRYGRFISCSAYPQCKYIEALNKPKGTGITCPQCKVGELVEKRSRYGKIFYSCDTYPKCSYALWGPPLQRPCPRCAWPILYQKSTKRRGEELVCPQAECAFHFPAAAEDAEVQRLLADYTPPPPKDDADAAARPRRAAKTVKKAAAGPKSAAAAKTVRSKPTSRTANKSKTSKKPTVKA
(453) DNA topoisomerase III [Acidithiobacillus caldus SM-1]
7
MFIAEKPSLGKGIAKYLSGSASSGKGYIQCGPDVVTWCFGHVFEQVEPDYYLPDDVPLANNGKKKWRFEDLPIFPEHWKLEAKDDAKAQIKVIRDLLKKADVVVNAGDPDREGQLLVDEVLEELGWKGPTQRIWLAALDEQSVKKALSSIRDNREYQNLCNAARARSRADWLVGMNLSRAFTLRNSGGGVVSIGRVQTPTLALIVARDEKIENFQPKEYFVPRIHTGFWSSWELHEDFSGVDGEGYLTDCKAADSLIARAQAEGRAVVQEYESREKQQSATLGFSLAELQKVCSAKLGMSAQQVLDAAQALYETHKCATYPRTDCRYLPEEQFAEASRVLSGLARLGFGDLVKNADAARKSSIWNTGKVTAHHAIIPTGGMESRPEGATAKVYEIIVRSYLAQFYPPYVFRAIKAVLGCAGESWKATANVPVAPGWKAVYGLSEEEGEAAQQPIPVLQTGQVLPVQDADVQAKQTKPPARFTDGSLIEAMSNIHKFIEDEAAKAKLKEASGLGTEATRASILETLLGRGFVERKGKQLISTRAGRELVKALPRELTDPVTTAKWEDALSLIAEGKLTLEQFEEVQRAVVARHIAAAKSSHFTVGEARSRNGKGAATGKARKLGPTCAACKQSKTVVLRAKSGKNWLKCEACGAAFWPEKNGKGCGTPWEARA
(1531) DNA topoisomerase 1 [Pectobacterium carotovorum subsp. carotovorum PC1]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSVSKKSADSTTKDKTKKKVKKDEKSALVNRMGVDPYHGWQANYEILPGKEKVVSELKTLAENADHIYLATDLDREGEAIAWHLREIIGGEDERFSRVVFNEITKNAIKQAFEKPDTLNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVDREREIKAFVPEEYWELHADLLAGSDIQLQMQVTHHSGKPFKPVNKEQTQAAVSLLENARYVVADREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALTMVRGYIGEEFGKRYLPESANLYSSKENSQEAHEAIRPSDVGVLADSLKDMETDAQKLYQLIWRQFVACQMTPAQYDSTTLIVEAADYQLRAKGRTLRFDGWTKVMPALRKNDEDRTLPTVAVGEALSLQKLLPGQHFTKPPARYSDASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESRLDQVANNQAEWKAVLDEFFNEFSQQLEKAEQDPEEGGMRPNAMVLTSIDCPTCSRQMGIRTASTGVFLGCSGYALSPKERCKTTINLIPENEVLNVLEGDDAETNALRARRRCEKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIETGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTSETCSNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLAEAPVVDKDGNKTQVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEGKK
(1549) DNA topoisomerase 3 [Pectobacterium carotovorum subsp. carotovorum PC1]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGQNDVVTWCVGHLLEQAQPDVYDARYARWSLADLPIIPQKWLLQPRPSVSKQLNTIKKLLNDANEVIHAGDPDREGQLLVDEVLEYLALPEEKRQQVRRCLINDLNPQAVERAVSRLRENREFIPLCVSALARSRADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVAKDYFEVKAHIVTPADERFVALWQPSESCEPYQDEEGRLLHRSLAEHVVKRIEGQPAFVTSYNDKRESETAPLPYSLSTLQIEAAKRFGLSAQQVLDVCQKLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISVHQPDLLPQPVMDVDRRNRCWDDGKVDAHHAIIPTARSASASLTENERKVYGLVARQYIMQFCPDAVFRKCVIELDIAGGKFITKARFLAEAGWRTLLGGKERDEENEGMPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRTFLFKKARYIHASEAGRALIHSLPASAAHPDMTAHWEATLTQISEKKCRYQDFMQPLTHSLQELIQQAKQNGAVRAFKGLSAPQSGAAKRRKPQTKKAKEQEQ
(1645) DNA topoisomerase 3 [Yersinia pseudotuberculosis IP 32953]
10
MMRLFIAEKPSLARAIADILPKPHRRGGGFIACGNDQMVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNVIKQLLQQADEVVHAGDPDREGQLLVDEVLDYLGLAAEKRQNVRRCLINDLNPQAVERAVERLRYNREFIPLCVSALARARADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIESFIPKDFFEVKAHIVTPADERFIALWQPSDSCESYQDEEGRLLHRPLAEHVVNRITGQPALVTSYNDKRESETAPLPFSLSTLQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISLHQSDLLPLEVMDSDRRNRCWDDKKVDAHHAIIPTARASKVNLTTDEGKVYRLVAQQYLMQFCPDAQFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKGAELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKELKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHASPAGRALIHALPDIAARPDMTAHWESTLTQISEKNCRYQDFMQPLVMTLQDLISQAKQNRSPQVFRGLPAGPSGAPKKRKKISSKAKESKS
(1341) DNA topoisomerase 1 [Yersinia pseudotuberculosis IP 32953]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSANSAEEKAKKDDKPKKKVKKDEKVALVNRMGVDPYHGWKAQYEILPGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNISRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREKEIKAFVPEEYWELHADLVAKGDIPIQMEVTHAHGKPFKPVNREQTHAALTLLENARYKVLDREDKPTSSKPSAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPATPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQRLYQLIWRQFVACQMPPAKYDSTTLTVQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSDLDLQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESGLDQVANDQAEWKTVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVMTSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPDAEILNILEGDDAETNALRARRRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEAGEFRIKGYEGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVVDKEGNKTLVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEAKK
(1569) DNA topoisomerase [Xenorhabdus bovienii SS-2004]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSITVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPVQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILLGEQTEPLWQAGLGRARADWLMGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMAALQKDDISFRVKWLPAPDDCDEEKRCIREDIAQSVVQRCQQAQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDASTLSRVWNDSQITAHHAIIPTRHTFDMTKLTADELKIYQLIRHYYLAQFLPVQETDVTDVTFTIGGQVFQAKGRVSVVTGWKTLFADEKQVQEQDDNTALPALKKEEICPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEALFNRQLLARKKKNLHATPLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRATLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVTGSRKTRRGNSPD
(143) DNA topoisomerase 3 [Xenorhabdus bovienii SS-2004]
10
MRLFIAEKPSLARAIADILPKPHRRGDGFIECGNNQFVTWCVGHLLEQAEPDTYDSRYARWVLSDLPIIPEKWRLKPRAAVAKQLNTIKSLLEKADEVIHAGDPDREGQLLVDEVLDFLNLRDDKKQNVQRCLINDLNPQAVIKAVERLRSNREFIPLCVSALARARADWLYGINMTRAYTLLGQNAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFVPKDFFEVKAYIVTPNEEQFTALWQPSESCIDFQDEEGRLIHQPLAEHVVARITGQPAYVTAYQDKRESETAPLPFSLSSLQIEAAKRFGLSAQNVLDICQRLYETHKLITYPRSDCRYLPEEHFVGRHAVLNAISIHSSDLLPQDALESDKKNRCWDDKKVDAHHAIVPTARSSQVNLTENERQIYGLIARQYLMQFLPDAVFRKCTIELDIAGGKFIAKARFLAEAGWRTLLGNKERDEENEGTPLPVVAKGDELLCEKGEVVERQTQPPRPFSDATLLSAMTGIARFVQDKSLKKVLRATDGLGTEATRAGIIELLFKREFLYKKGRNIHATPAGRALIHVLPDMAVLPDMTAHWESKLTQISEKQFRYQDFMLPLQETLQQLIWQAKQYRNLKAFRDLPPVPMKGKKGKTKQVKKGKEKVNKTE
(1819) DNA topoisomerase 1 [Xenorhabdus bovienii SS-2004]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGAASQKSSNSSTDKNKKKKDEKTALVNRMGVDPYHGWEADYQILPGKEKVVAELKMLAEKADHIYLATDLDREGEAIAWHLREVIGGGEARFSRVVFNEITKNAITQAFDNPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEREREIKAFVPEEYWQLHADLMAKGDIDLHMEVTHEGGKPFKPINAQQTQAAVSLLEKARYKVLDREDRPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALDMVRGYINDQFGDKYLPKTANIYSNKENSQEAHEAIRPSSVDVMAEELKDMEADAQKLYQLIWRQFIACQMMPAKYDSTTLTIQAGNFELRAKGRTLRFDGWTKVMPALRKGDEDHTLPVVEVGTELDLKQLSPSQHFTKPSARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVRGENRRFYAEKMGEIVNDRLEENFNELMSYDFTARMEDQLDHVANNEANWKGVLDEFFTNFSEQLDVASKDPDEGGMRPNPMVSTSIDCPTCSRPMGIRTATTGVFLGCSGYTLSPKERCKQTINLIPENEILNILEGDEAETNALRARHRCKECGTAMDSYLIDNQRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGSEMHLKMGRFGKYMGCTSEECKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAASTFPKSRETRAPLVEELVKFKDRLPEKLCYLAKAPVADPEGHKTVVRFSRKTKQQYVSSEKNGKATGWAAFFVDGAWVVKEK
(1568) DNA topoisomerase [Xenorhabdus bovienii SS-2004]
4
MPLYLCEKPSQARDIARVLGVKQRGQGYLFGDSITVTWAIGHLLEMAAPEHYGEQFGPPWRMEPLPVLPVQWQWTVKKETADQFAVIRQLLKQADEVIIATDADREGEVIARELLEYCRFTGPVRRLWLSALDETSIRQALAAILLGEQTEPLWQAGLGRARADWLMGINLTRLYTLKAQAQGFGEVLSIGRVQTPTLALVVNRDNDIARFEPKPYWQVMAALQKDDISFRVKWLPAPDDCDEEKRCIREDIAQSVVQRCQQAQDAVVTELTQKREKTPPPLCFDLGMLQQVASRQWGMGAGQVLTIAQSLYEIHKATTYPRTDCGYLPVSMREDIPAVFTALTRTDPAMNAIISQLDASTLSRVWNDSQITAHHAIIPTRHTFDMTKLTADELKIYQLIRHYYLAQFLPVQETDVTDVTFTIGGQVFQAKGRVSVVTGWKTLFADEKQVQEQDDNTALPALKKEEICPVLRAEIQPRQTRPPAPFTEGTLIAAMKNAAAFIHDPQLKKVLRENAGLGTEATRAGIIEALFNRQLLARKKKNLHATPLAQELIAGLPDVLTHPGMTALWEQSLDDIARGRATLDGFMQKQAQWLAHLVEKGKTQPIRFTLPKTPACPRCGGPMQKRAGKTTPFWGCTRYPACKGMLNANAVTGSRKTRRGNSPD
(1793) DNA topoisomerase 3 [Haemophilus somnus 129PT]
10
MRLFIAEKPSLARAIADVLPKPHQRGQGFVKCGEQDYVTWCVGHLLEQAAPDVYNPMFKQWRLEHLPIIPQKWLLLPRQEVKSQLDIVLKLIHQADIIINAGDPDREGQLLVDEVFSYAKLPATKLAEIQRCLINDLNPSAVEKAIKKLQPNKNFIPLATSALARSRADWLYGINMTRAYTIRGRQSGYNGVLSVGRVQTPVLGLIVRRDLEIEHFQPKDFFEVQAFIATKEKMPSTFTALWQPSKACEDYQDEEGRVLSNALAKNVVKRITAQPATVTEYIDKREKETAPLPYSLSALQIDAAKRYAMSAQEVLDVCQKLYETHKLITYPRSDCRYLPEEHFSARHTILRAISTHSILYKEIPDIVNTELKNRCWNDKKVEAHHAIIPTAKNKTVSLSQNEQQIYDLIARQYLMQFCQEAEYRKSKITLDIAGGTFIAQARNLQIAGWKQLWGKEDEDEQQEPLLPIVKKGDELFCEKGDVISKKTQPPKPFTDATLLSAMTGIARFVQNKELKKILRETDGLGTEATRAGIIELLFKRGFIYKKGRNIHSTETGRTLIQALPEIATQPDMTAHWEAQLDSISRRQGSYQQFMQTLSELLPELLGYFNFSALRKLGLQTKENKKADLKKNE
(600) DNA topoisomerase 1 [Haemophilus somnus 129PT]
9
MSKSLVIVESPAKAKTINKYLGNQYVVKSSVGHIRDLPTVGESSGEKAKPISTKGLSAEEKQRIKTEKEQNALVKRMGIDPYHNWEAKYQILPGKEKVVSELKSLAKKVDHIYLATDLDREGEAIAWHLREVIGGEDSRFSRVVFNEITKNAIKQAFEKPEQLNLDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLVVEREREIKAFQPQEYWEISVDSKNSQKRPIRLDVVQFQGKKFEPKNIEQTRSAVDFLQISDYFVKDLEIKPTTSKPKAPFITSTLQQSASTKLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSKDALEMVRNYIVQEFGQAYLLDKPNFYSSNENAQEAHEAIRPSDVKQLADSLEGMERDAVRLYDLIWRQFVACQMPAAKYDSTTVTVQSGDYELKSKGRVLRFDGWTKVLPQSNRNPEDQELPIVKVGEKLSLTKVEPQQYFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRVENRRFYAEKMGEIVTDRLNQSFADLMSYDFTANMENILDQIADGKKNWKEELNQFFKDFSQQLTQAELDELDGGMKPNSLVATDIGCPTCNRQMAIRTASTGVFLGCSGYALPPKERCKTTINLIPEAELLNVLDESSETKALMERKRCSKCDTAMDSYLIDTTRKLHICGNNPNCDGYLVEQGEYKIKGYEGPIVECDKCGGEMHLKLGRFGKYMGCTNCDNTRKILKSGEVAPPKEDPVHFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRESRPAKVAELAQYQDRLPEKLRYLADAPVKDPEGNEAIIRFSRKEKRQYVTSEKNGKTTKWSAYFVDGKWVENSK
(614) DNA topoisomerase [Haemophilus somnus 129PT]
4
MKLFLCEKPSQGRDIAKVLGATQKGEGYLSTADGTIVVTWARGHLVEHFSPEQYDPALKAWRLDTLPIIPSQWQVSPKPDAKKEYKTVMTLLKKARTVVISTDIDREGETIARELLDLAGYRGHIQRLWITALDEISVRKALSRLKTNEETLPLYYAGLARSRADWLIGMNFSRMFTLLAQQQGYQGPPLSVGRVQSPTLALVVNRDKEIAHFVPTYHYALMVQVCGTNAQSFEASLLVPEQYCDEEGRCLEIKVLQQAEQQIRQAGQVCVQNVETKREKESPPLLFALSDLQAECNRLYDLGTQQVLDIAQSLYEKHKATTYPRTDCGYLPEAQLLEVPQVINSLMQSDAKLQPLRVQLNLSQKSRAWNDKKITAHHGIIPTTQPVDIAKMNENEFKVYDLIRRRYLAQFLPHFEVDKTRVRLSCGEHQCIAKGQVIVSAGWKALFRASKEEQGEKQGLPILNSGQMLKVMNTEIKSLKTTPPAHYTEGTLLTAMVNVARFVTDERLKKQLRETEGLGTEATRASIMKTLYDRGYIKKKGKSIVATDAGVMLIDNLPTVLKDPGLTALWEQALNQIAENQMSLQEFMQKQEQFVLHLIQTCGHQGIKMGNIDIKKCPQCGKPLRKMKGKNGDFLGCTGYPKCKYIESGAKRKTSAGKVTPINLSQQFANLRQAVK
(1336) DNA topoisomerase 3 [Edwardsiella tarda EIB202]
10
MRLFIAEKPSLGRAIADVLPKPHRRADGYIQCGDGDVVTWCVGHLLEQAEPDAYDARYARWNLADLPIVPQKWQLRPKASSAKQLKVIEHLLRDAQQVVHAGDPDREGQLLVDEVLDFLALAPEKRRQVQRCLINDLNPQAVARALERLRDNHEFMPLCVSALARARADWLYGINMTRAYTLLGRNAGYNGVLSVGRVQTPVLGLVVRRDEEIAHFVAKDYYEVRAHIVTPAGERFWAQWQPSEACEPHQDEEGRLLNRALAEHVIARIQDKPARVTGYNDKRESEVAPLPFSLSALQIEAAKRFAMSAQQVLDTCQRLYETHKLLTYPRSDSRYLPEEHFAGRHAVMAAIAAHAPTLANLESVDVQRRNRCWDDSKVDAHHAIIPTARAGSVALNEDERNIYQLVARQYLMQFCPDAQYRKCVIDLEIEGGIFIAKARFLSQAGWRALLGAKERDDEDEGMPLPVVARDDLLHCERGELMARQTQPPRHFTDASLLSAMTGIARFVQDKSLKKILRATDGLGTEATRAGIIELLFRRGFLHKKGRYIHASPAGSALIHCLPEMAGRPDMTAHWEATLTKISERGCRYQDFMHPLVETLQQLIHQARTAVNPRAFRDLPPAESARPRRAKGASTASNKRKKA
(1290) DNA topoisomerase 1 [Edwardsiella tarda EIB202]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKGAASADDKAKTKAKKNERDALVNRMGVDPYHGWQAHYEVLPGKEKVVSELKSLAEKADHIYLATDLDREGEAIAWHLREVIGGDDSRYSRVVFNEITKNAIQQAFSQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLIVEREREIKAFVPEEYWELRADLAVGAEVSFQAQVTHCNDKPFKPVNAAQSQAAVAALEHARFAVREREDKPTSSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALNMVRAYIGDNFGAEYLPADANVYASKDNSQEAHEAIRPSDVNVLADDLKGMEADALKLYQLIWRQFVACQMTAAKYDASTITVQAADYTLKARGRTLRFDGWTRVLPQLRKGDEDRALPAVESGRALDLLQLQPSQHFTKPPARFSEASLVRELEKRGIGRPSTYAAIISTIQDRGYVRTDNRRFYAEKMGEIVTDRLEENFRELMSYDFTAHMEDGLDRVASAQADWKVMLDGFFSDFSQQLEVAEKPPEEGGMRPNPMVLTSIACPTCERQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEAEVLNVLEGDDAETNALRAKRRCPKCGTAMDSYLIDNHRKLHVCGNNPACDGYEVEEGEFRIKGYDGPIVECDKCGAEMHLKMGRFGKYMGCTNEACKNTRKILRNGEVAPPKEDPVPLPELACEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAEAPQQDEQGNATLVRFSRKTKQQYVSSEKEGKATGWTAFFIDGKWVVSEKK
(772) DNA topoisomerase 3 [Klebsiella oxytoca KCTC 1686]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDVYDARYARWNLLDLPIVPEKWQLQPKPSVTKQLNVIKRLLGDAQEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPKDERFVATWVPSEACEPYQDEEGRLLHRSLAEHVVKRIEGQPATVTAYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAIGVHAADLLPQPVVDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLSDNEEKVYGLIARQYLMQFCPDAVFRKCQIDLDIANGKFVAKARFLAEAGWRTLLGNKERDEENDGMPLPVVAKDDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESILTQISEKQCRYQDFMQPLVGTLFQLIDQARSTPVRRFRGIVAPGDGKKSFSKGKGRAKAKDKKSAAGPAAESPQ
(60) DNA topoisomerase 1 [Klebsiella oxytoca KCTC 1686]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTSTKGAKKPKKDERGALVNRMGVDPWHDWNAHYEILPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEQRYSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWEVDASTTTPGGDALPLQVTHNGDKPFRPVNRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPESANQYASKENSQEAHEAIRPSDVNVLAETLKDMESDAQKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKGDEDRTLPMVNKGDSLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWKQVLDSFFGDFTSQLQTAEKDPEEGGMQPNPMVLTTIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCKKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLAEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVASEKDGKATGWSAFYIDGKWTEAKK
(1188) DNA topoisomerase 3 [Erwinia billingiae Eb661]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGQDQMVTWCVGHLLEQAQPDSYNSRFARWSLADLPIVPEKWQLKPRPSVAKQLNVIKGLLEQATEVVHAGDPDREGQLLVDEVLDYLSLPPEKRANVQRCLINDLNPSAVERAVSRLRENKEFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGLLSVGRVQTPVLGLVVRRDEEIENFIAKDFFEVKAHIVTPKDERFVALWQPSDSCEPYQDEEGRLLHRPLADHVLARIGGQPANVTSYNDKRENDTAPLPFSLSSLQIEAGKRFGMSAQTVLDTCQKLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINAHQPDLTPPADFDSDRRNRCWDDKKVDAHHAIVPTARSSQVRLTENESTIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFVAKARFLAEAGWRSLLGSKERDEENDGTPLPVVAKGDELLCERGEVVEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRAFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMLPLVETLHNLIYQARQQPAAHAFRGLPAAEPKKPRRKATKAKETE
(686) DNA topoisomerase 1 [Erwinia billingiae Eb661]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTVKKSADSTTSKPAKKVKKDEKAALVSRMGVDPFHGWEADYQILPGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDSRFSRVVFNEITKNAIRQAFEKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFTPEEYWELHADLNTPKGTGLPMEVTHQHDKPFRPVNGEQTHAAVSLLEKARYVVADREDKPTSSKPGAPFITSTLQQAASTRLGYGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDAVSMVRGYIETEFGAKYLPKAANVYSSKENSQEAHEAIRPSDVAIQSEQLKDMEADAQKLYQLIWRQFVACQMMPAQYDSTTLTVAAGDFKLKAKGRTLRFDGWTAVMPALRKGDEDRTLPPVEVGEELKLQQLKPSQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEANFRELMNYDFTAHMEDNLDKVANNEAQWKGVLDQFFADFSQQLEKADKDPEEGGMQPNQMILTSIDCPTCNRKMGIRTASTGVFLGCSGYALPPKERCKQTINLIPENEVLNILEGDDAETNALRARHRCQKCGTAMDSYLIDNQRKLHVCGNNPGCDGYEIEQGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGDVAPPKEDPVPLPELTCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELQRFRDRLPEKLSYLADAPVSDEEGNKAVVRFSRKTKQQYVSTEKDGKATGWSAFYVDGKWEVASKATATKAAPVKAAANKATATKATAKKAAKK
(935) DNA topoisomerase 3 [Serratia sp. AS12]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGNNDVVTWCVGHLLEQAQPDAYDSRYARWSLADLPIIPEKWQLQPRPSVSKQLNAIKKLLHDADEVVHAGDPDREGQLLVDEVLDYLALTPEKRHSVRRCLINDLNPQAVERAIDRLRDNRDFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVPKDFFEVKAHIVTPKEERFVALWQPSDSCEPYQDEEGRLLHRPLAEHVLKRIEGQPALVTSYNDKRESDTAPLPFSLSTLQIEASKRFNLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRHAVLNAISAHQPDLYPQPVIDSDRRNRCWDDKKVDAHHAIIPTARASKVSLSQDELNVYGLVARQYLMQFCPDAMFRKCVIELDIAGGKFVAKARFLAEAGWRTLLGSKERDEENEGSPLPVVAKDDELLCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIELLFKRAFLYKKGRYIHSSETGRALIHSLPDIAARPDMTANWEATLTQISEKSCRYQDFMQPLVGTLQELIYQAKQSRASMAFRGLPPSPSAGAKKRKKSAGKAREKSE
(1639) DNA topoisomerase 1 [Serratia sp. AS12]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADSTEDKAKKKVKKDEKTALVNRMGVDPYHGWKADYEILPGKEKVVAELKSLAENADHIYLATDLDREGEAIAWHLREVIGGDEKRFSRVVFNEITKNAIQQAFKQPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKNDTALQMEVTHAHDKPFKPVNREQTHAALKLLEKARYTVLDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALNMVRGYIGDNFGDKYLPKAPNQYSSKENSQEAHEAIRPSDVNVLAEQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLSVKAGDYQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPYVEVGSDLELQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVESRRFYAEKMGEIVTDRLEENFRELMNYDFTARMEDGLDQVANNHAEWKAVLDEFFAEFSEQLETAEKDPEDGGMRPNQMVMTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPETEVLNILEGDDAETNALRARHRCQKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIEEGEFRLKGYDGPVVECDKCGSEMHLKMGRFGKYMGCTNETCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELARFKDRLPEKLRYLADAPVADGEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(40) DNA topoisomerase [Serratia sp. AS12]
4
MQLYLCEKPSQGKDIGAILGATQRKQGYLAGAGVIVTWAIGHLLEQAQPETYGEQFGSPWRESVLPIVPTQWKMAIKKDTADQFAVIRGLLKQVDSVVIATDADREGEVIARELLEHCHFTGPVQRLWLSALDEASIRHALANKLPGEKTAPLYEAGLARSRADWMTGMNLTRLYTLKAREQGYGEVLSIGRVQTPTLALVVNRDRDIANFISKPYWQVRGTLQKGGIAFPANWVPAANYCDEEKRCIQQNVAQAVVQRCQQTAHAVVLEVGTERKKESAPLAFDLGTLQQACSRKWGMSANQVLSIAQSLYETHKATTYPRTDCGYLPTSMREEVADVLSAVTRTDPTLNESVARLDRAFVSRIWNDKKITAHHGIIPTKQPFDLSKLSADELKVYQLIRQHYLAQFLPLHEVDVTEATFNIGGQLFRTRGKVEAVAGWKVLFQHDVSEAKEEPADTDDVRLPALVKGETVAVAGAELKTLQTKPPGHFTDGTLIAAMKNAAAFVSDPQLKKVLKENAGLGTEATRAGILETLFKRGYLEKKGKYLLSTPIAGELIDALPTALTNPGMTALWEQALDEIAQGQMTLDTFMSRQAQWTGHLVEKGKTQAVKFTAPPSPPCPTCSGSMRRRAGKKGGGAFWGCSNYPTCQGVINIDAKGGRKAKRYKAKSPTKNKATGSE
(866) DNA topoisomerase 1 [Francisella cf. tularensis subsp. novicida 3523]
1
MAKNLVIVESPAKTKTIKKYLGNEFEILASFGHVREIPSKDTSIDVNDNFKIKFTTSEKSKKHLDAIKKAAKDAQNIYLATDPDREGEAISWHVQEVLKSARLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVDAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLIEFNNNKVEQFTFTTAEDAENAKVDILKDANGFLIVDGITEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIQAKYDKDMLPAKPRVFEKKSQNAQEAHEAIRVTAANRTPESIKQFLTSDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHKFRVTGTVIVDAGFLKIYNVEKDEDDKDSDDEQTLPKFEKGERITLNDVITKAHSTEPPPRYTEASLVKALEKYGIGRPSTYATIISTLQQREYVEVDKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIAHHKNDYLSVLNNFWHPFIERINKISEDVSRKDVVQEELDEDCPECGSKLSLRLGKNGRFIGCTNYPTCKYTRPVDSDPKEVAKEEPVVVEDRKCPKCSSDLHIKQGRYGKFIGCSNYPECKHMEPLEKPKDTGVVCPKCNKNHIVEKKSRKGKVFYACAGFPKCKNAYWYPPIKEECPKCHSPILLHKTTKKDGEQKACPNSECDYAVPFEAK
(780) DNA topoisomerase 3 [Gallibacterium anatis UMN179]
10
MRLFIAEKPSLARAIADVLPKPHHRNDGFIRCGENDYVTWCVGHLLELAEPDAYNPAFKQWRLEHLPIIPQQWQFLAKKSTAKQLAVIKQLLKQADVIVHTGDPDREGQLLVDELFAYFKLPKEKIATIQRCLVNDLNSAAVSKAVNKLQPNQDFKFLTISALARTRADWLYGINMTRAYTLRGQQVGYQGVLSVGRVQTPVLGLIVRRDLEIEHFVPKDFFEVQAIIHHSVETVADNPQLKGYPFKALWKPSEACEPYQDEEGRVLSKALAEHVVKRISEKSALVTEYQSKTEKEMAPLPYSLSALQIDAARMYGMSAQQVLDICQRLYETHKAITYPRSDCRYLPEEHFAEREKIFSAISNNCQQYQSFESGFNPAQKNRCWNDKQVEAHHAIIPTAKQGLRLNSEEQKIYQLVARQYLMQFYPDAEYHKTKIQLSIDNGTFIAQTRGLANAGWKKLQGKEDADPQSNISALPVVKKGDELYCSSAEVLNKKTQPPMYFTDATLLSAMTGISRFVQDKALKKVLRETDGLGTEATRAGIIELLFKRGFLTKKGRQIHSTEAGRILIGALPEIATQPDMTAHWEQQLEQIYRKGLSYQAFMQQLTAQLPQLIQQIDLQKLMSLRNVPQQQHSKKRFTRRSSTASQN
(464) DNA topoisomerase 1 [Gallibacterium anatis UMN179]
9
MGKSLVIVESPAKAKTINKYLGNSYIVKSSVGHIRDLPTSGSGNGEKAKPVSTKGLSAEEKAKIKQKKERDALVKRMGIDPYHNWKANYQILPDKEKVVSELKSLAKKSDHIYLATDLDREGEAIAWHLREVIGGEDERFSRVVFNEITKNAITQAFSHPEQLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFQPEEYWQIAVETKNAEQQLLPFEVTHYQSKPLQIKDKQSADKATETLKNSRYIVTEVETKPTQSRAKAPFITSTLQQTASTRLGFGVKKTMLLAQRLYEAGYITYMRTDSTNLSQDALTMARAYISDNFSAAYLPEKPNFYSSKENAQEAHEAIRPSDIQLKADDLQGMEKDAIRLYDLIWRQFLACQMTAANYDSTTVTATADDYTLKVKGRVLRFDGWTKVLPPLGKNAEDRVLPEVKKGEELTLLQVIPSQHFTKPPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVRTENRRFYAEKMGEIVTDRLNESFPDLMNYDFTANMEDVLDQIAAGKTDWKQQLNQFFADFSTKLSQAELDELEGGMKPNHLVETNIPCPSCGRPMAIRTASTGVFLGCTGYALPPKERCKTTINLIPEAELLNVLDDNSETKALMERKRCPKCGTAMDSYLIDAHRKLHICGNNPNCDGYVVEEGQFKIKGYDGPVVECDKCGADMHLKLGRFGKYMACTQCDNTRKILKNGEVAPPKEDPIPFPELKCEKSDAYFVLRDGASGVFMSAHNFPKSRETRPAKVSELAQYRDRLPEKLQYLADAPQQDPEGNPTVIRFSRKEKRQYVNSEKEGKATKWIADYIDGKWVARAK
(288) DNA topoisomerase [Gallibacterium anatis UMN179]
4
MKLILCEKPSQGRDIGKFIGATKRGEGYLSSPDQQTFVTWGIGHLVEQAEPQDYDESYKKWIFDNLPIIPDKWIMKVKKETAKQYKIVMGLIKKANHIVIATDPDREGEVIARELLDMANYKGKVQRLWLSALDDGSIRKALANLKSDAETKPLYAAGLARGRADWLVGMNLTRLFTLIAQKQGYQGVMSVGRVQSPTLAIVVQRDREIENFVSKPFYRLKVNLDGFCAYWQPTESVCDDEGRCIDYSVITQVQRQLSKTLKIDNIETKRKKEMPPLAFDLGTLQQTCSRLFGMGAAQVLKIAQSLYETHKATTYPRTDCGYLPESMIDEIPLVLKAVSESDPQVRNIVAKLDISLRSRVWNDSKITAHHGIIPTTQKVDLSKMSDDELKVYQLVRKHYFAQFLPLYEEDNTSVLLSGNEQTFVSKGKQVIKIGWKSLFQQDRNEDDEEQSLPSLRQGQSCNVVDSEVLTLKTTPPKHYTEGTLIAAMKNAARFVTDARLKQRLRETEGLGTEATRAEVIETLFKRGYLEKKRKEIVATSAGRSLIDGLPDIIKDPGMTALWEQALNDIASGKMLLQDFMAKQNQFISHVVKSMIGSGSVAIQVKAEKICPKCGAAMRRRKGKNGDFWGCSNYPTCTAIENIGSRKRVGKSR
(1551) DNA topoisomerase 1 [Ferrimonas balearica DSM 9799]
9
MGKSLVIVESPAKAKTINKYLGKDFVVKSSVGHIRDLPTSGGQAAEKAPPSKTPAEVRKMDPEAKAAYKRERDYQSLIGRMGIDPEHGWAANYQVLPGKEKVVKELQTLAEKADTVYLATDLDREGEAIAWHLQEVIGGDPERYRRVVFNEITKSAIQEAFSHPLHLDNAKVDAQQARRFLDRVVGFMVSPLLWKKLARGLSAGRVQSVAVRLVVEREREIRAFVPEEYWDLHADLSSASGDALRMQVARFNGEALKMVNQGDADKAVSALKEARYTISAREDKPSSSKPSAPFITSTLQQAASTRLGFGVKKTMTLAQRLYEAGHITYMRTDSTNLSKEAVESVRGYIGQEFGNQYLPSSPNLYGAKQGAQEAHEAIRPSDVNVKASTLSTMERDAQRLYELIWRQFVACQMVPAKYDSTTVTATAGSYELKAKGRIMVFDGWTRVQPPMGRKGDEDTMLPAVQVGDVLDLKALDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFFAEKMGEIVTDRLVENFTDLLNYHFTAEMEQTLDKIAQGKLEWKAVLDQFYSDFTEKLTQAELAPEEGGMRANQMVMTDIACPTCGRPMGIRTATTGVFLGCSGYALPPKERCKTTINLTPGEEAEAITSDDQEAAALVTKRRCSKCESTMDSYLIDETRKLHVCGNNPVCDGYEVETGSFKIKGYDGPIIECDRCGSDMELKNGRFGKYFACTDSKETGCKNTRKLLKNGEVAPPKEDPVQLPELPCEKSDAHFVLRDGAAGLFLAASTFPKSRETRAPKVEELKRFKDRISPKFYYLAEAPQADPEGNPAVVKFSRKTKEQYVASEVDGKPTGWIARFENSRWVEEQTKKSKAKK
(1626) DNA topoisomerase 3 [Ferrimonas balearica DSM 9799]
10
MRLYIAEKPSLGRAIAAVLPKPHRNGDGHIVVGNGDVVTWCIGHLLEQVEPEAYDARYQRWALSDLPIRVDNWQLKPRKGGAKQLQVIKKLLKQATDVVHAGDPDREGQLLVDEVLDYLKLDDARRHSARRLLISDLNPAAVTRALKGMKSNREFAPLSVSALARSRADWLYGMNLSRAYTLLGQQAGYRGVLSVGRVQTPVLGLVVRRDEAIANFVAKPFYQLDALIEHDSGVIRARWQPSEACQRWLDEEGRLLSRGLAENVASRIAGQPATVVTSEHKESSQAAPLPYSLSALQIDANKAFGMNAQEVLTLAQSLYEKHKVITYPRSDCRYLPKDHFAEAGAVTQAIARCLPELDGAVSGADLKRRSRAWNDSKVTAHHAIIPTPKAVAPHSLSGKEAKLYGLIARQYLMQFYPAAQYAESKLVFTIGSGHFVAKGKVLRQPGWRALLPKKPEAESRATLPELAPGSQWPCRGGEIKDCMTEPPKAFTEATLLQAMTGIARFVLDDTLKGILRETDGLGTEATRAGILELLCKRGLLRREGKTLRSTPSGQGLIHALPEQASYPDMTAHWERKLQDIAEREYGYAPFMADLDQRLLALVTQAQQGGVPPSLRNLPAVARKAPVRRRRKTAKKTPSQ
(15) DNA topoisomerase 3 [Dickeya zeae Ech1591]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGDQDTVTWCVGHLLEQAQPDAYDARYARWSLTDLPIVPQKWLLQPRPSVSKQLNVIKKLLTQADEIIHAGDPDREGQLLVDEVLEYLALSEEKRQHVRRCLINDLNPQAVERAVSRLRENREFVPLCVSALARSRADWLYGINMTRAYTLLGKNAGYEGVLSVGRVQTPVLGLVVRRDEEIDNFVPRDYFEVKAHIVTPANERFVALWQPSESCEPYQDDEGRLLHRPLAEHVVKRIEGQPAWVTAYNDKRESETAPLPYSLSALQIEAAKRFGLSAQQVLDICQRLYETHKLITYPRSDCRYLPEEHFAGRQAVLNAIATHRPDLLPQPAVDPERRNRCWDDGKVDAHHAIIPTARSARTSLTEQESQVYGLVARQYLMQFCADAVFRKCVIDLDIAGGKFVAKARFLAEAGWRTLLGNKERDEENEGMPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKALKKILRETDGLGTEATRAGIIELLFKRAFLIKKGRYIHSTDAGKALIHALPPIAAHPDMTAHWEATLTQISEKRCRYQDFMQPLTQSLYELIQQARQSGNIQAFRGLPAVKRATPEKRKRRQSRSASTKE
(1778) DNA topoisomerase 1 [Dickeya zeae Ech1591]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSGSASKKSAEANGEKAKKAVKKDERTALVNRMGVDPYRGWQAHYEILPGKEKVVSELKMLAQNADHVYLATDLDREGEAIAWHLREIIGGDEKRFSRVVFNEITKNAIRQAFENPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEYWELHADLLANAETALQMQVTHHHGKPFRPVNQAQTQAAVSLLEKASYVVNEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMARDYIQGEFGKRYLPDAPNLYTSKENSQEAHEAIRPSDVSVLADQLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLVVSAADYQLRAKGRTLRFDGWTKVMPALRKSDEDRTLPAVEIGQSLSLEKLSPSQHFTKPPARYSEASLVKELEKRGIGRPSTYAAIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEDNFRELMNYDFTARMENSLDLVANSQAEWKAVLDEFFAEFSQQLETAEQEPDEGGMKPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLIPEAEVLNVLEGDEAETNALRARRRCSKCGTAMDSYLIDNQRKLHVCGNNPSCDGYEIEQGEFRLKGYDGPVVECEKCGSEMHLKMGRFGKYMACTSDSCGNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFRDRLPEKLRYLADAPVTDPQGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYVDNKWVETAR
(1586) DNA topoisomerase [Dickeya zeae Ech1591]
4
MRLFLCEKPSQGKDIGRVLGTTQRGNGCLTGSGITVTWCIGHLVEAAPPETYGEQYKRWSIEQLPIIPECWRVEVKSKTASQFNVVKELLSKATELVIATDADREGELIAREIIELCGYRGPIQRLWLSALNDTSIRKALSVLRPSDETLPMYFSALARSRADWLIGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWAVEVVLSSAGQHFTAAWLAPDTAADNAGRCLQEPIARQATERMRVTGSAQVTSVETEHMREGPPLPFDLGTLQEVCSRQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPIVFDSLLKTDPDLRPIVDLLDRNQRSRAWNDSKVTAHHGIIPTLEPANLAAMSDKERAVYTLIRTHYLAQFLPHHEFDHTTAYLSCAGEMLQAVGKQVVLVGWRRVLTEPKPDDDGDTTSRSQVLPPLNEGLSCQITGIDCKALKTSPPRPYTQGELVKSMKSVAKLVSDPRLKQTLKDTTGIGTEATRANIIKGLLDRGYLLKKGRSVRASDAAFTLIDAVPGAIADPGMTAIWEQALDMIESGQLTLDVFIDKQSAWIAQLIQQYRGASLSIQMPLGPACPECGTPMHQRPGKNGAFWSCPRYPDCRGSLPIDSGKRKRTTPRKRNSSLQAS
(1641) DNA topoisomerase 3 [Shigella dysenteriae Sd197]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRYLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSGFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKARIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGRKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEAGSGAIV
(1216) DNA topoisomerase 1 [Shigella dysenteriae Sd197]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVDKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSYFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPENLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(105) DNA topoisomerase 1 [Francisella philomiragia subsp. philomiragia ATCC 25017]
1
MAKNLVIVESPAKTKTIKKYLGNDFDILASFGHVREIPSKDTSIDVNDNFKIKFTTSERSKKHLDAIKKAAKSAENIYLATDPDREGEAISWHVQEVLKNAHLLKDKNVYRVTFNEITKSAVTNAIENPKELSMDLVNAQKARQALDFLVGFNLSPLLWRKITSGLSAGRVQSPALRMIVEREIERENFIKQDYWSLTADTFKQKQIFANLIEFNNTKVEQFTFIAEKDAKKAKSTIVKDANGFLIVEGVTEKKTRRNPYPPFITSTLQQEASKKLGFTAKRTMSTAQKLYEGIDLGNGESVGLISYMRTDSTNLSNDALNDIRNFIESKFDKDMLPSKPRVFDKKSQNAQEAHEAIRVTAANRTPESIKQHLTSDEFKLYSLIYNRTIACQMKHATLNSTSVDLITENTKHKFRVTGTVIVDAGFLKIYNVEKDEDEKDSDDEQTLPEFEKGEKVPLKDIITKAHSTEPPPRYTEASLVKALEKHGIGRPSTYATIISTLQQRDYVEVEKRRFIPTDKGRIVNKFLTEYFKKYVEYSYTAGLEKELDEIANHKNDYLSVLNSFWHPFIEKINKISEDVSRKDVVTEELDEDCPECGSKLSSRLGKNGRFIGCTNYPTCKYTRRVDSDGKEVEKEEPTVVEDRKCPECGSDLHIKQGRYGKFIGCSNYPTCKHMEPLEKPKDTGVVCPKCNKNNIVEKKSRKGKVFYACSGFPKCKNAYWYPPIKEDCPKCKSPILLHKTTKKDGEQKACPNPECDYAVPWEENN
(897) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Enteritidis str. P125109]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1734) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Enteritidis str. P125109]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(358) DNA topoisomerase 3 [Erwinia pyrifoliae Ep1/96]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGYIACGSDQVVTWCVGHLLEQAQPDSYNSRFARWSLDDLPIVPEKWRLQPRPSVAKQLNVIKGLLAQASVVVHAGDPDREGQLLVDEVLDYLTLPAEKRAQVQRCLINDLNPQAVERAIGRLRENREFIPLCVSALARARADWLYGINMTRAYTLLGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVRAHIVTPADERFVALWQPSASCEPYQDEEGRLLHRPLAEHVVARIGGHPAHVTSYNDKRENETAPLPFSLSALQIEAGKRFGLSAQTVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVLNAINVHQPNLSPPGDFNSDQKNRCWDDKKVDAHHAIIPTARSSQVSLSDNEQQIYRLIATQYLMQFCPDAVYRKCVIELDIAGGKFVAKARFLAEAGWRALLGSKERDEENDGTPLPVVTKGDELLCERGEVQEKQTQPPRPFTDATLLSAMTGIARFVQDKDLKKVLRATDGLGTEATRAGIIELLFKRTFLFKKGRYIHSSPAGRALIHSLPEMAARPDMTAHWESTLTKISEKQCRYQDFMSPLVDTLHSLIQQARQQPAAHAFRGLPAPATDKTKRPRRKTAQKKESET
(1770) DNA topoisomerase 1 [Erwinia pyrifoliae Ep1/96]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSTVKKSADSTTSKTTKKVKKDEKTALVNRMGVDPFHGWEANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGDESRYSRVVFNEITKNAIRQAFDRPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLVVDREREIKAFVPEEYWELNADLTTPKGVDLPMQVTHQHDKPFRPINREQTYAAVSLLEKARYVVVDREDKPTGSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALSMVRGYVEEEFGAKYLPKTANLYSSKENSQEAHEAIRPSDVKVQSEQLKDMDADAQKLYQLIWRQFVACQMVPAQFDSTTLTVEAADFKLKAKGRTLRFDGWTRVMPALRKGDDDRTLPAVEVGSELSLQQLLPGQHFTKPPARFSEASLVRELEKRGIGRPSTYASIISTIQDRGYVKVESRRFYAEKMGEIVTDRLEENFRELMNYDFTAHMEDNLDKVANNEAQWKAVLDQFFGDFSQQLEQAEKDPEEGGMQPNQMVLTSIECPTCSRQMGIRTASTGVFLGCSGYALSPKERCKQTINLIPENEVLNILEGDDAETNALRARRRCGKCGTAMDSYLIDNQRKLHVCGNNPECDGYDIEQGEFRIKGYDGPVVECEKCGSEMHLKMGRFGKYMACTNDDCKNTRKILRNGDVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPQVEELQRFRDRLPEKLRYLADAPAKDADGNKAVVRFSRKTKQQYVSTEKDGKASGWSAFYVDGKWEVTKK
(787) DNA topoisomerase 3 [Pectobacterium wasabiae WPP163]
10
MRLFIAEKPSLARAIADVLPKPHRRGDGFIACGQNDVVTWCVGHLLEQAQPDVYDARYARWSLADLPIIPQKWLLQPRPSVSKQLSAIKKLLNDASEVIHAGDPDREGQLLVDEVLEYLSLSEEKRQQVRRCLINDLNPQAVERAVSRLRENREFIPLCVSALARSRADWLYGINMTRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEEIENFVSKDYFEVKAHIVTPADERFVAIWQPSESCEPYQDEEGRLLHRSLADHVVKRIEGQPAFVTSYNDKRESEIAPLPYSLSTLQIEAAKRFGLSAQQVLDVCQKLYETHKLITYPRSDSRYLPEEHFAGRHAVLNAISVHQPDLLPQPVMDVDRRNRCWDDGKVDAHHAIIPTARSASASLTENERKVYGLVARQYIMQFCPDAVFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGGKERDEENEGMPLPVVAKGDELLCERGEVVERQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRTFLFKKARYIHASEAGRALIHSLPDSAAHPDMTAHWEATLTQISEKKCRYQDFMQPLTNSLQELIQQAKQNGAVRAFKGLSAPPSGASKRRKPQAKKAKEQKQ
(1350) DNA topoisomerase 1 [Pectobacterium wasabiae WPP163]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHVRDLPTSGSASKKSADSTTKDKTKKKVKKDEKSALVNRMGVDPYHGWKANYEILPGKEKVVSELKTLAENADHIYLATDLDREGEAIAWHLREIIGGDDRRFSRVVFNEITKNAITQAFEKPDTLNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVDREREIKAFVPEEYWELHADLLAGSDIQLQMQVTHHNGKPFKPVNKAQTHAAVSLLENARYIVADREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALTMVRGYIGEEFGKRYLPEAAIAYSSKENSQEAHEAIRPSDVGVLADSLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLIVEAADYQLRAKGRTLRFDGWTKVMPALRKNDEDRTLPTVAVGEALSLQKLLPGQHFTKPPARYSDASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESRLDQVANNQAEWKAVLDEFFNEFSQQLEKAEQDPEEGGMRPNAMVLTSIDCPTCSRQMGIRTASTGVFLGCSGYALSPKERCKTTINLIPETEVLNVLEGDEAETNALRARRRCEKCGTAMDSYLIDNQRKLHVCGNNPACDGYEIETGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMSCTGETCSNTRKILRNGDVAPPKEDPVPLPELSCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPEVDKDGNKTQVRFSRKTKQQYVSSEKDGKATGWSAFYIDGKWVEGKK
(556) DNA topoisomerase [Pectobacterium wasabiae WPP163]
4
MCEKPSQGKDIGRVLGATQRGNGCLAGSGITVTWCIGHLVEAAPPETYGEQYKRWSIEQLPIIPERWRVEVKSKTASQFNVVKNLLSKATELVIATDADREGELIAREIIELCGYHGPIQRLWLSALNDASIRKALAALRPSGETLPMYFSALARSRADWLIGMNLSRLFTVMGRQAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPFWTVETVLSSAGQSFTAGWLAPDTATDDAGRCLQEPIARQAAERMRIAGSAQVTSVETERLREGPPLPFDLGTLQEICSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPVVLDSLLKTDPGLRPIVDQLDRNQRSRAWNDSKVTAHHGIIPTLEPANLTAMSDKEQAVYKLIRAHYLAQFLPQHEFDRTTACLSCTGETLQAVGKQIVVIGWRQVLTEPRPDEDGETTLRSQVLPALHEGLSCQITGIDCKALKTSPPRPYTQGELVKAMKGVAKLVSDPRLKQKLKDTTGIGTEATRANIIKGLLDRGYLLKKSRSVRASDAAFTLIDAVPGAIADPGMTAIWEQALDMIEAGQLTLDVFIDKQSAWITQLVQQYRGASLSIKVPQGPACPECGTAMRQRTGKSGPFWSCPRYPDCKGSQPIDSGKHKRAMPRKRSRSSREP
(551) DNA topoisomerase [Pectobacterium wasabiae WPP163]
4
MRLFICEKPSQARDIAAVLGATKRGQGFLSAPGITITWARGHLLETASPEVYGTQFEKPWRIDVLPVLPPVWQMVVKSESSDQFTVISRLLKQVDEVVISTDADREGEVIGWSLLEYCGWRGPVFRLWLSALDESSIRAALAAIKPGSETKPLYYAGLGRSRADWLIGMNLTRLYTVKARDKGYDGLLSVGRVQTPVLAMVVNREREIATFVPKPYWQVWVALQSNGVRFSAQWVPAKMYVDEEKRCIHQDIAQQVAQLCKQTGKATVIEQETKREKEAAPLAFTMGTLQQACGRLWDMSPQKVLDIAQSLYETHKATSYPRTDCGFLPESMREEIPDVLSALVKIDPSLQALISQLDTRFVSRIWDDKKMTAHHGIIPTRHVCDMSKMSDQEKQVYVLIRRHYLAQFFPLHEVDFTRLSLNIGGQLFQTTGRVVVVPGWKRLFSQDDGEHKEAAADEKDQSLPMLVKGDNCGVAGSEVKALKTKPPQYFTFQSLIAAMMNAAAYVTDLTLKKVLKENAGLGTEATRGGIVETLLARNFISIKGRYLRATDIAMDLIDALPHALKEPGMTALWEQALDEVAKGRMTLDSFMSRQTQWICQLVSLGTQQDVVVRVPPTPACPLCGSKTRLRKGAKGAFYGCEKYPDCKGMINVPGQSKNAASKTRKKKQN
(454) DNA topoisomerase 1 [Cellvibrio japonicus Ueda107]
9
MGKSLVIVESPAKAKTINKYLGSDFVVKSSIGHIRDLPTSGNNKPVDTKERARQAAATRKMSAEQKAVYQAQKSKSQLVGRMGIDPENHWEAHYEILPGKEKVVDELKKLAEKADAIYLATDLDREGEAIAWHLREAIGGDESRFRRVVFNEITKTAIQNAFKSPGPIDQNRVDAQQARRFLDRVVGYMVSPLLWEKVARGLSAGRVQSVAVRLVVEREREIRAFIPEEYWTLFADLKAESGQIASFEVKKQGEEAFKPINEAQAMAAVTALQHAAYKVVSREDKPTQSKPTAPFITSTLQQSASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQEAVESCRTYILDNFGQKYLPKEPVAYSSKEGAQEAHEAIRPSSVDVMPNQLSAMERDAERLYGLIWQQFVACQMTPAEYTSTSVVVEAGNYELRTRGRVIRFDGYTRVLPQQAKKDEDVVLPDMKVGQVLPLVKLNPQQHFTKPPARYTEASLVKELEKRAIGRPSTYAAIISTIQERGYVRQENRRFYAEKMGDIVTERLMESFDDLMDYGFTANMEEALDQVAQGDKNWRQLLDEFYADFSQQLDTASRQDKGMRANDPTDTNIPCSLCGRHMQIRTGSTGVFLGCSGYALPPKERCKNTMNLVSGHEVIDADADDEAESRQLRSKHRCKLCNSAMDSYLIDEQRKLHICGNNPDCPGYEVEQGVYRIKGYEGPTIECDKCGSEMQLKTGRFGKYFGCTNADCKNTRKLLKNGEAAPPKVEPIAMPELRCEKVDDHYVLRDGAAGLFLAASQFPKNRETRAPLVAELLPYKNQLDPKYHFLLSAPVSDPEGNKAIVRFSRKTKEQYVQTEVNGKATGWKAFYVNGRWQVQK
(355) DNA topoisomerase 1 [Pseudomonas fulva 12-X]
9
MGKSLVIVESPAKAKTINKYLGSQYVVKSSIGHIRDLPTSGGAATKEPAKRGKAAAGEAPALSPKEKAKRQLFARMGVDPEHGWKAKYEILPGKEKVVEELRRLAKEADTIYLATDLDREGEAIAWHLRESIGGDDSRYKRVVFNEITKKAIQEAFSAPGELDINRVNAQQARRFLDRVVGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREKEIRAFVPEEYWEVHADLGTAKDAQVRFEVVRENGAAFKPLNEAQAMAALATLKASSYSVAKREDKPTSSKPTAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAIEMVRGFIDKEYGKKYLPEKPNFYSSKEGAQEAHEAIRPSDVNLRPTQLSGMERDAERLYELIWRQFVACQMPPAEYLSTTVTVNAAQFELRAKGRILKFDGYTRAQPQLSKPGDDAMLPEMKESESLKLIKLDPSQHFTKPPARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTERLSESFSDLMDYGFTAGMEENLDDVAQGEREWKHLLDEFYGDFKKKLEVAADGDNGMRANTPTLTDIPCRECGRPMMIRTASTGVFLGCSGYALPPKERCKATINLVPGDEIAADDEGESESRVLLGKHRCPICATAMDAYLLDETRKLHICGNNPDCAGYEIEQGQFRIKGYEGPSLECDKCGSQMQLKTGRFGKFFGCTNSECKNTRKLLRNGEPAPPKMDAVKMPELKCEKVDDTYVLRDGASGLFLAASQFPKNRETRAPLVLELLPHKDEIDPKYHFLFDAPAKDPEGRAAVIRYSRKTKEQYVQTEVDGKPTGWKAFFDGGKWKVEDKR
(315) DNA topoisomerase [Pseudomonas fulva 12-X]
4
MRLFLCEKPSQAKDIASVLGATRRGDGCWLGNGVTVTWCIGHLLETAPPDAYDARYKRWVLDDLPIVPQQWKMRVKANTAAQFKAIKRLLGEASELVIATDADREGEMIARELLEHCRYRGPIQRLWLSALDDASIRKALAALKPGASTYNLYQSALGRSRADWLIGMNMSRLFTLLGRKSGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPVPFWAIDVTLDGNGIPFTAVWRAPQDDCDEQGRCLKQEVAQRAAEAMQGAEHAVLEKLKTERMREAPPLLFDLGTLQQVCSKKLGLGAQETLDIAQKLYETDKLITYPRSDCGYLPLSQHAEAPAILAALGQADPTLREVLAHTQTQRRSRAWNDAKVSAHHGIIPTLAAGGLTRLSGRPRAVYELIRARYLAQFLPNHEYDRTQADFDCAGHDLRAVGKQIVEPGWKRALPEALAPSKGREAPAPQALPALHEGQTCAVREVTLKDQFTQPPKPFTEGDLIQAMKNVARLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLTKQGKTLAATSAAFGLIDAVPRAIADPGTTAIWEQALDMVQSGEMPLDEFVAKQSAWMARQIERCRGLQLTISGPPPGGRPAWKGKRKGASRKKAASAKRAGASAAGGRSK
(872) DNA topoisomerase 1 [Methylomonas methanica MC09]
1
MSKSLVIVESPAKCKTIEKYLGKDFQVLASYGHVRDLIPKEGAVDPEHGFAMKYQVIDRNQRHLQEIGKALKNADTLYLATDPDREGEAISWHVFEHLKEKKLLKDKQVLRVVFHEITKKAVTEAIEHPTELSLTMVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRMIVERELEIEAFKTREYWSHTADASAQGQPFKAKLTHFNGEKLTQFSITDETQANQVKQALLDAGDGQLIVAKLEKKQRSKNPAPPFITSTLQQEAARKLGFTTKRTMMVAQQLYEGIDLGGETVGLISYMRTDSVNLADEALADIRALIAEKYGAGNVPKEPRQFKTKSKNAQEAHEAIRPTSVQRLPEQVKERLTVEQFKLYDLIWKRTVACQMIHATLNLVAVDLNCGSDKNVFRATGSTVTNPGFMMVYLEGVDDSKEATDDQDRLLPPMEEGRPVVLNDVTANQHFTEPPPRYSEASLVKALEEHGIGRPSTYATIISTLQNREYVTIDSKRFYPTDVGRIVNKFLTEHFTKYVDYDFTANLEDDLDAVARGEKDWIPLMNDFWRPFTQLISEKEESVQRKDVTQESIDEQCPECGSPLSIRLGRNGRFVGCTNYPTCSYTRNLGEDSAAATAEPEVVEGRVCPKCASPLVIKTGRYGKFVGCSAYPTCKHIEPLEKPQDTGVECPQCKKGSILKRKARSGKIFYSCSEYPKCSYALWDAPIKESCPDCHWPILTLKTTKRRGTEKVCPQKECKYATPYEGDPEDVNGPG
(504) DNA topoisomerase 1 [Xanthomonas albilineans GPE PC73]
1
MSKHLLIVESPAKAKTINKYLGKDFHVLASYGHVRDLIPKEGAVDPDDGFAMRYALIDKNEKHVDAIAKAAKAADDIYLATDPDREGEAISWHIAEILQERGLLKGKPLHRVVFTEITPRAIKEAMAHPRQIAGDLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFLAREYWTIGAECAHPSQPFAAKLVKLDGQKFEQFTITDGATAEDARMRLQKAAQGALHVTDVTSKERKRRPAPPFTTSTLQQEASRKLGFTTSRTMRVAQKLYEGVTVGDEGTVGLISYMRTDSVNLSQDALVEIRDVIARDFGTGALPDKPNTYQTKSKNAQEAHEAIRPTSALRTPAQMAKYLDDDGRRLYELIWKRAVACQMVPATMNTVTVELAAGSEHSFRASGTTVIDPGFLAVYEEGKDQKAAEDEDEGRKLPAMKPGDRIPLDRIHADQHFTEPPPRYSEASLVKTLEEYGIGRPSTYASIIQTLMFRKYVELDARRFRPTDVGRAVSKFLSGHFTRYVDYDFTAKLEDDLDAVSRGEEEWRPLMEKFWGPFKELVEEKKESVDRSEATGARELGTDPKTGKPVSVRLGRFGPYAAIGSTAEDAEDKPKFASLRPGQSMHTITLEEALELFLMPRLLGQDKGDDVSVGIGRFGPFAKRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRIIKQFPDSDIQVLNGRFGPYISDGKLNGKIPKDREPSTLTLDEVQKLLEETGKPVRRGFGAKKVAAKKEAAPKKSPAKKTVADTPTKTAAKKAVKKATKKTVKKAVKKAAKKTVAKVAKGA
(120) DNA topoisomerase 3 [Proteus mirabilis HI4320]
10
MRLFIAEKPSLARAIADVLPKPHKRGDGFIVCGDNQYVTWCVGHLLEQAEPDAYDPRYARWSLDDLPIIPNKWQLKPRADVKKQLDTINTLLKQADEVIHAGDPDREGQLLVDEVLNYLNISDAQRKQARRCLINDLNPAAVSRAIDKLRYNHEFIPLCVSALARARADWLYGINMTRAYTLLGQRNGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPKDFFEVKAHIVTPADERFTAIWQPSEHCEPWQDEEGRLLHRKLAEHVVDRIAGKPANVTDYQDKQESEIAPLPFSLSALQIEAAKRFGLSAQQVLDTCQRLYETHKLITYPRSDSRYLPDEHFAGRHAVMNAISVHDNSLLPQETLDIDKKNRCWDDKKVDAHHAIIPTAKTGNISLSENEKNIYYLIARQYLMQFMPDAVYRKCVIELDIENGKFIAKARFLAQAGWRTLLGSKEQDAENDGSALPIVAKGDELLCEKGEIVAKQTQPPRPFTDATLLSAMTGIARFVQDKELKKILRATDGLGTEATRAGIIELLFKRGFLQKKGRAINSTPAGRALIHVLPDMATLPDMTAHWESILTQISEKQFKYQDFMMPLSNTLFELITQAKRRPNIQAFRNLPAPAQNKKRKGATKKSAQGKSRSAQSQSTNRNIKSDA
(1301) DNA topoisomerase [Proteus mirabilis HI4320]
4
MKLFLCEKPSQAKDIARVIGAHQRRDNFFQGNGVQVAWARGHLLEQAEPEAYGAQFAAPWRQSALPVIPEQWKMVVKKDAVSLFQTIKQLLSQATEVVIATDADREGEVIARELLEACHYRKKVQRLWLSALDEASIRQALNNLLPGEKTASLYSAGLGRARADWLIGMNMTRLFTLKARELGFGGILSVGRVQTPTLALIVRREREITHFVSKPFWRVTASLQHQGIIFQAHWRPASQYCDDEHRCIHVQAAQAVEQLCRQAGKATVCTVNETKGKALPPLPFDLGTLQQAASRRWGYSADKVLEIAQSLYEKHKATTYPRTDCGYLPVSMRADIPVVLDALSQSDPALQNVLAQLQPARISRVWNDAKITAHHAIIPTRQTPDLNAMNEAELNVYKLIRAHYLAQFLPDQEWDATEVFLDIGGQQFVAKGKVERVKGWSVLFVKHEDDPPVKEEAETGLEAGTETLPSLHEGEFCVVQEAKVVQLATSPPKPYTDGTLIAAMKNASSFITDPTLKKVLKENAGLGTEATRAGIITTLENRKLIVRQKKTLRATDTGCQLIDALPAACTDPGMTALWEQSLEQVAQGNLSLDVFMQKQISWLAHLIKKGGEMPLALDLPPMPSCPSCHGKMVLRESSKGRFWSCQRYPDCKGSVPLPEKMQGVTRGMNKRKKAVKKSITGLFT
(1656) DNA topoisomerase 1 [Proteus mirabilis HI4320]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPKSGSGSQKSENSSATKGVKKVKKDEKSALVSRMGVDPYNGWHANYQILPGKEKVVAELKALAEKADHIYLATDLDREGEAIAWHLREVIGGEDDRFSRVVFNEITKNAITQAFQTPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKVARGLSAGRVQSVAVRLLVEREREIKAFVPEEYWQLHASLLTPDEQPLRMEVTHYQDNAFKPVSSEETQVAVKALQNATFIVKNREDRPTSSKPSAPLITSTLQQAASTRLSFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDAIQMARDYIHDKFGAKYLPKEPNVYSSKENSQEAHEAIRPSDINVTAESLKDMDSDAKRLYQLIWDQFVACQMTPAKYDSTTLTVVSGDYKLRAKGRTLRFAGWTKVMPAMRSKDEDKTLPAVDVGAQLALAELSPTQHFTKPPARFSEATLVKELEKRGIGRPSTYASIISTIQDRGYVKVENRRFYAEKMGEIVTDRLEENFSDLMNYDFTAQMEDHLDHVANNQENWKAVLDAFFTDFSQQLEVAEKDPEEGGMRPNPMVITSIECPTCSRHMGIRTATTGVFLGCSGYALPPKERCKQTINLIPEDELLNILEGDDAETNALRARRRCPKCGTAMDSYLIDTHRKLHVCGNNPACDGYEVEEGEFRLKGYEGPVIECDKCGAEMHLKMGRFGKYMGCTNEECKNTRKILKSGEIAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPKVAELVRFKDRLSEKMRYLAQAPVTDPEGNPTIVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEKSK
(514) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Heidelberg str. SL476]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAEETGRQTE
(1555) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Heidelberg str. SL476]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(725) DNA topoisomerase 3 [Salmonella enterica subsp. enterica serovar Agona str. SL483]
10
MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQSVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVDTLYQLIEQAKRTPVKRFRGIVAPGGGEKKKSAPRKRAGKKSPPAEETGRQTE
(1136) DNA topoisomerase 1 [Salmonella enterica subsp. enterica serovar Agona str. SL483]
9
MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWDAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFEQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDANTTTPSGEALPLQVTHQNDKPFRPVNREQTLAAVSLLEKARYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIGDNFGKKYLPDNPNQYASKENSQEAHEAIRPSDVAVMAESLKDMEADAQKLYQLIWRQFVACQMTPAQYDSTTLTVGAGEFRLKARGRILRFDGWTKVMPALRKGDEDRTLPAVNKGDALTLLELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEDSLDQVANHQAEWKAVLDNFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALSPKERCKTTINLVPENEVLNVLEGDDAETNALRAKRRCQKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNDECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGIFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTVVRFSRKTKQQYVAAEKDGKATGWSAFFVDGKWVEGKK
(1869) DNA topoisomerase 1 [Shigella sonnei Ss046]
9
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTIGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKIGEIVTDRLEENFRELMNYDFTAQMENSLDLVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGKK
(131) DNA topoisomerase 3 [Shigella sonnei Ss046]
10
MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIIPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERALDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLLQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDVVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA
(1846) DNA topoisomerase 1 [Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica)]
1
MEKNLVIVESPAKAKTIEKFLGKGFSVKSSIGHIRDMPKKNMGIDIENNFAPTYEITTDKKKVVADLRKAVKAAEKVYLATDEDREGEAIAWHLLEALNLPKDTPRIVFHEITESAITHAIVEPRTVDYQLVDAQQARRIIDRLVGFEISPVLWRKISGARSAGRVQSPVMRLVVEREREISQHITNSTYKVKAELTSEGGGLFEVKLSKEFESKKKVLDFINAFLSANLTVTSIEKKSYKRSPKPPFITSTLQQEASQKLGFSVKQTMTLAQNLYREGFITYMRTDSFTLSEIAIDVTGQIIVKEFGSEYHHIRRYKTKDTSAQKAHEAIRPTNLTKPSIFGIEDQAAKLYSLIYKRTLACQMSDAQLQKTQIKINISGLDEKFLANDEILTFPGFLRVYDYFSSENKLLPDLNKEDMLSLASFKARESFSRAKPRYTEASLVKKIEEMGIGRPSTFATMVSTVQDRNYVTKETREGVERGYQLIEIKDNQIIQSQPSEVTGAEKNKLFPTNVAYLLTDFLVKYFNNIIDYEFTAKLENDFDAIATQNISWQGVVKNFYTPFHKKIEDAADISREETHGMRELGTDPKSGKLVSVRFGRYGAFAQIGHKDDEDKPIFASLRDSLDIESITLDEALELFNMPRTVGETDDFGTIKANYGRFGPYIEYDKKYVSLKEDIPEKVSLEKALELIAYKEKFDAERIIKTFDDSNIKVLKGRFGPYIWNGKKKGKGQKNITIKKVFGNKNPVDLTLKECKKAVSGKIKAKAKPRKKKKVIKK
(1066) DNA topoisomerase 1 [Nitrosococcus oceani ATCC 19707]
1
MSKNVVVVESPAKAKTIKKYLGKNFEVLASYGHVRDLMPKEGAVDPEHGFKMKYQAIEKNGRHVNAIAKALKSADFLLLATDPDREGEAISWHLLELLKEEGVLEDKAIQRVVFYEITSQAVNEAVAHPRDISLDLVNAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLICEREKEIDAFKVREYWTLEADAAASKQEFVAKLTHLDGKKLAQFDIESKDQALALVDRLTKAASGELRVIKVERKQRRRNPAAPFITSTLQQEASRKLGFSTKRTMSVAQQLYEGVDIGDGAIGLITYMRTDSVNLANEAVGEIRNFITERFGQSGLPAKPRTFKTRAKNAQEAHEAVRPTSVYRVPEALKPHLKPEQFKLYQLIWRRTIACQMKHATIDTVAVDLNTQKLAPEGGNSASGHIFRATGSTVVDPGFMAVYQEGRDDIKGEEEQRKLPPMKEGDRVTLLQIRPEQHFTEPPPRYTEASLVRALEEFGIGRPSTYATIISTLQQRDYAVLENKRFQPTDVGRVVNRFLTEHFNSYVDYDFTARLEDELDAVSRGEKVWIPVLEEFWGPFSARIQEKEQNVSREEAVQARELGIDPQSSRPVSVRMGRYGPYIQIGSKEDEEKPRFAGLQPGQKMDAITLEEALTLFKLPRELGFTPGGEQVSVNVGRFGPYVKYDNKYVSLRGEDPHTISLERALALIEEKKQADANRVIKVFPDSGIQVLNGRYGPYVTDGERNARVPKEQAPEALSLEQAQALINEAPVKRARRKAGTRKKAKG
(304) DNA topoisomerase 3 [Vibrio sp. EJY3]
10
MSRLFIAEKPSLGRAIAAALPNPQKKDQGFIRCGNGDVVTWCIGHLLEQVEPDAYDERYKKWNMADLPIVPEQWQLRPRKTSSKQLTVIRKLLKEATEVIHAGDPDREGQLLVDEVLDYCKLSKTKKQATQRLLISDLNLPAVKRALSSMRSNRDFIPLSVSALARSRADWLYGMNMSRAYTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFIPKDYFTLHALIPYQDQNGAFDIRARWKPSEACKPWQDEEGRVLNRKLVENVAARIKNQPATVKESEQKQTKQSAPLPYSLSALQIDAAKRYGMSAQQVLDTCQALYEKHKLITYPRSDCRYLPMEHYAQVGSVTSAIANNAKELQSAVQGADLSIKSKAWNDKKVDAHHAIIPTPKQANVNALSGNEMKVYQLIARQYLMQFYPAAIYAEAKLVFDIAGGTFIAKGRQLVSPGWKALMGKTDKEDDGIDAVPPLAEGTVLTCREGEIKDRKTEPPKHFTEATLLQAMTGIARYVADKELKKILRDTDGLGTEATRAGILDTLFKRQLLTRQGKSILSSPAGRGLVHALPQDATYPDMTAHWEFQLQGMAEKNQAYQPFMQALEQRIDSLMGEVKSGPIPESLRHLPKVERPAFKRKKRSYSKGSASKSGAPKRKSS
(989) DNA topoisomerase 1 [Vibrio sp. EJY3]
9
MGKSLVIVESPAKAKTINKYLGKDFVVKSSVGHVRDLPTAGQSTGEKAAAISTKGMSAEEKARVKKEKDRKALIKKMGINPYHDWEANYQILPGKEKVVSELQKLAKDADYVYLATDLDREGEAIAWHLREIIGGDEERYKRVVFNEITKNAIQQAFQTPGELNMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREINAFVPEEFWDIHANTKTKDKADFKLLVAQKDGVAFKPVNEAETKAAMSVLEKASYEVCKREDRPTKSKPSAPYITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVDAVRDFIGSEFGDKYLPASPLKYGSKEGAQEAHEAIRPSSVDVKAEDLQGVDADAHKLYALIWNQFVACQMTPAEYDSTTISVKAEEFTLKAKGRILKFDGWTRVQRPMGKNEDTILPAVQLGDKLNLESLDPKQHFTKPPARFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFYAEKMGEIVTDRLDDSFNDLMNYDFTARMEQKLDQIAEGEVNWKSVLDNFFTDFTGDLEKADLDESEGGMKLNHIVMTDIECPTCGRPMGIRTASTGVFLGCSGYALPPKERCKTTINLGDEEGIINVLEEDVETAALRAKKRCPICETAMDAYLIDDKRKMHVCGNNPNCEGYIVEYGEFKVKGYDGPVVECDKCGSDMVLKNGRFGKYMDCTSETCKNTRKILKNGEVAPPKEDPVHFPELPCENSDAYFVLRDGASGLFMAASNFPKSRETRAPLVSELALYEERLPEKFKYLATAPQEDPDGRPAVVRFSRKTKENYVRSEENGKPSGWTALYVDGKWEVTDKRKKAKA
(173) DNA topoisomerase 3 [Shewanella putrefaciens CN-32]
10
MILYIAEKPSLGRAIADVLPKPHKKGDGFIEAANGDCVSWCVGHLLEQAEPDAYNPEFKAWKFEHLPIVPDKWQLTPKAATRSQLTVLKRLVKQASMLVNAGDPDREGQLLVDEVIAYLGVTGDKLHQTQRLLISDLNPQAVKRALTQLRSNREFIPLSTSALARSRADWLYGMNMTRAYTIQGKKVGYQGVLSVGRVQTPLLGLVVRRDKEIANFQSKPFYEVLAHLATDKQETFSAKWQPSEACQPYMDEEGRVLARGLAQNVVSRISDKPALVTQLVAKDKKQHPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLYERHKLITYPRSDSRYLPVEQHNLAPSVLKAISDGAAELLQGADAPDPRLKSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHIARQYLAQFYPAYCYCETTVQVTIEGGLFNTKARQDKSLGWKQLFARQEPNGSKASGNKSTEESMGKDDEENDEFIGQLPPLKLGQALHCTRGELLEKNTQPPKAFTDATLLSAMTGISRYVTDPEIRKILKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVSTDVGKGLINSLPLSATTPDMTALWEASLNGICHKETSYQGFMQPLLGTLSTLIQHAGAQLPTALNGLKGQGYRKTASHKSGYRKSYSKKSSSAKGIGTTKNDVSNKYGSKNTSSKSSVTRSTSRSASNSRKSTAAV
(620) DNA topoisomerase 1 [Shewanella putrefaciens CN-32]
9
MGKSLVIVESPAKAKTINKYLGKEFIVKSSVGHIRDLPTSSTSEGNEKVKSAAEVKKMSPEEKAQYKKVKDQQALVSRMGVNPEKGWAAKYQILPGKEKVVKELQALADSADQIYLATDLDREGEAIAWHLQEVIGGDPSRYQRVVFNEITKSAIQDAFSKPSTLDTNMVNAQQARRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVRLVVERESEIKAFVPEEFWDVHAQLTTPAEESLRMEVVKHLDSAFEPINEQQALAAVQALSSASFNVISREDKATQSKPSAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQEALESVRDMIGKAFGAKYLPAEPIRYGSKEGAQEAHEAIRPSNVHVEATDLTDMERDAQRLYELIWRQFVSCQMTPAQYDATKLTVKAGDYELKATGRTLRFDGWTRVQTVLKKKNEEDNTLPFVSQGDVLALKELQPKQHFTKPPARYSEASLVKELEKRGIGRPSTYATIISTIQDRGYVKVENRRFYAEKMGEIVSERLVSSFADLMSYDFTASMEQTLDDVARGELDWKKVLDGFYADFTKQLEKAERDPEEGGMRLNQMVMTDIKCPTCGRPMGIRTGTTGVFLGCSGYELPPKERCKTTMNLTPGVEAISENSEDAETDALRAKHRCGICGTAMDSYLIDEKRKLHVCGNNPICEGYEVEEGQFKIKGYEGPLIECDRCGHDMELKNGRFGKYFGCTNEECKNTRKLLKNGEAAPPKEDPIYLPELKCSKSDAHFVLRDGAAGIFLAASTFPKSRETRAPLVEELVKYRELLWPKYQYLADAPICDDEGNKAAVKFSRKTKEQYVATEVDGKATGWSAHYINGKWVSESTAKKSKKA
(345) DNA topoisomerase 3 [Aggregatibacter aphrophilus NJ8700]
10
MRLFIAEKPSLGRAIADVLPKPHQRGDGFIKCGDNDYVTWCVGHLLEQAEPDAYDARFKQWRLEDLPIVPQKWLLIPKKETHKQLKTVEKLVHQAEILVNAGDPDREGQLLVDEVFSYLNLPAEKRNAIQRCLISDLNPSAVEKAIKKLQPNRDFIPLATSALARARADWLYGINMTRAYTIRGRQAGYNGVLSVGRVQTPVLGLIVRRDLEIENFQPKDFFEVLAWVRDPKEETALFSALWQPSKACEDYQDDDGRVLSRALAENVVKRITDQPAKVTDYTDKREKETAPLPYSLSALQIDAAKRFRMSAQEVLDTCQRLYETHKLITYPRSDCRYLPKEHFADRMAVMNAISTHLTPFQPLPEIIDPEQKNRCWNDKKVEAHHAIIPTAKNRAVSLTQAEQNIYFLIARQYLMQFCPDAEYRKCKITLDIVGGTFVAQARNLQIAGWKQLWGKEDNDDEQPDALLPVVKKGQILHCEKGDIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTEAGRILINALPDVATQPDMTAHWESQLDSISRKQASYQQFMQNLTQLLPELLHYINFSALRELSRHNQGVKKTASRTKKS
(96) DNA topoisomerase 1 [Aggregatibacter aphrophilus NJ8700]
9
MSKSLVIVESPAKAKTINKYLGSNYVVKSSVGHIRDLPTIGSANGEKAKPISTKGLSLEEKQALKQKKEQDALVKRMGIDPYHGWKANYQILPGKEKVVAELKSLAKKADHIYIATDLDREGEAIAWHLREVIGGDNERFSRVVFNEITKNAIKQAFEHPESLNMDRVNAQQTRRFLDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLIVEREREIKAFVPQEYWEVSVLTDTAKHEQIRLDVVQFKGKKFEPKNAEQAQSAVDFLTKSDYVISDLETKPTSSKARAPFITSTLQQTASTRLGFGVKKTMMLAQRLYEAGYITYMRTDSTNLSQDALNMVRGYIEKHYGAPYLPAKPNFYSSKENAQEAHEAIRPSDIHIGSHDLVGMEKDAERLYDLIWRQFVACQMPAAQYDSTTLTVRAGDYTLTAKGRILRFDGWTKVLPQPGKSPEDQALPDVAVNTTLNLLTVEPQQYFTKPPARFSEAALVKELEKRGIGRPSTYAAIISTIQERGYVRTENRRFYAEKMGEIVTDRLNQSFADLMNYDFTANMEDVLDQIASGTKDWKTELNQFFKDFSKQLSKAELDELEGGMRPNSLVPTDIHCPTCSRNMAIRTASTGVFLGCTGYSLPPKERCKTTINLIPEAELLNVLDDASETKALMERKRCPKCSTAMDSYIIDPHRKLHICGNNPNCDGYLIEEGKFKIKGYDGPIVECDKCGGDMHLKLGRFGKYMACTQCDNTRKILKNGEVAPPKEEPIHFPELRCEKSDAYFVLRDGAGGVFMSAHNFPKSRETRAPKVAELALYRDRLPEKLSYLAEAPQTDPEGNEAIIRFSRKEKRQYVTSEKNGKATKWIVDFVDGKWVERKK
Family distribution
Taxonomy tree
Gammaproteobacteria