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Taxon : Firmicutes
Informations
Name
Firmicutes
Rank
phylum
# topoisomerases
414
Lineage and sub-taxa
Lineage
Bacteria
>
Firmicutes
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(937) Putative DNA topoisomerase [Lactobacillus brevis]
3
MSIVVLTEKSSQIDPYAKALGTPKKKQGSVWVHSALLNADVQFVAASGHLFKLDGPEDYNDAWRDRSNYEQLPMVPQKFKARIKDARARASFNRIKQAITAADEVILATDPDQQGEVIGREILQRIPGGMEKCQRRLLNSSLTAKGALRSFENLVPMAKQEHLGAAGFLQNRLNWLIGMNLSRVGGIQLKKRGYYFPVAAGTVKTPTLALVVANDQEIKHFKEAPYWQIELTDQANQQRFKAQPSRHFSIEDEAKQALAQVTDTLTIKSVDQVEQHRLPPKLFNLTALQGYAAKKWGYSGTEVLETMEHLYKDLAITSYPRTESTVIEDAEFDYLKANFNDYAATLNLKMAMQVPDARPEFVKTTTDGHPALIPTDKVADLSQLTERERRCYGAVVKRTLLMFAGDCVLDKTVVKGTLGTEQIYEATGQQFKDLGWTEFDVVKTENRELPSYQQGQQVKIETSLVEGKTKVPQRITEGMLFSKLFPKYNLGTPATRAGIVSELIEKNHYIEVKGKRRELYPTSEGINMVAFWQGTLLTDLKLAKSWQDIFDKVIQGNMQPDRYQEQMVEALTDIVADYRTKKPDLPIAPKPHTSYEFKPLTPAVKCPKCHRGELGLLVATNAKNNQFYACSQKKCHFSLPNKYSGIALTSELVRQLATKKQTDWLPEVKSSQGKVYRNQVAFILAEKLKLQWTFKQTAKKTERTD
(1078) DNA topoisomerase 1 [Streptococcus gordonii str. Challis]
1
MYKLVTKTSKKSTTKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSTMSIDFENNYEPQYINIRGKGPLINDLRKEAKKAKQVFLASDPDREGEAISWHLAHILNLDEKEKNRVVFNEITKDAVKNAFKEPRQINMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEINAFKPEEYWTIDSTFKKGSRQFQASFYGINGRKMKLTNNDEVKEVLSLLKGDDFKVESVERKERRRNAPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAANYITDRFGAKYSKHGSKIKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMNVKIEQNGVQFTANGSQVKFDGYLAIYNDSDKNKMLPDMEKGDTVKRVNTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVKLVSKRFEPTELGEIVNSLIVEFFPGIVNVKFTAEMEAKLDDVEVGKEQWQKVIDEFYRPFEKEVAKAESEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVTCPQCQKGHVIERKTKRNRIFYGCNRYPDCDFTSWDKPVGRNCPKCDHYLVEKKVRGGGKQVVCSNGDYEEEKVK
(815) DNA topoisomerase 1 [Lactobacillus johnsonii NCC 533]
1
MPTKRKNKKNLVIVESPHKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGVDVEHDYEPKYISIRGKGDTIKELKSEAKKAKYVYLASDPDREGEAIAWHVAHALNLDPKEHNRVAFNEITKDAVKNAFKNPRTIDMDIVDAQQARRVLDRLVGYSISPILWQKVKKGLSAGRVQSIALKLVIDRENEIKNFKPEEYWTIDADFEKGSEKFKGAFYGIKGKKQELPNNEAVQDVLKRIDKRKNFEITKVVKKERRRQPAAPFTTSTMQQEANKRLGYRTRRTMRIAQSLYEGVNLGKGSVGLITYMRTDSKRIANVAKHEASKFIHEEYGENYAAVKPQHFKNDADAQDAHEAIRPTSAFRTPASVKEYLTTEEYRLYTLIWSRFIASQMTPAVYDTVRADIEQNDVTFRTTGSKLKFAGFTKVYDNQKEKSNELPELNEGDKVKLKKTDDRQHFTQPPARYTEASLVRTLEENGVGRPSTYAPTIDTIQKRYYVKLEGRSIVPTELGEIVDKLIEEFFPDIVNVDFTAQLENDLDGVEVGKKNWIKVVDEYYKPFSKELDKADQQIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKIGVTCPKCGKGEVIEKKSKRNRKFYGCSRYPDCDFVSWDQPIGRNCPNDGHFLVQKKNKKGLVILCPNGDYREEPEEN
(157) DNA topoisomerase III [Bacillus halodurans C-125]
7
MGAVVVIAEKPDQGMKLAAPFPHRNKRGYVEVAPCDQFPAGAFFTWAVGHLCELCPPEQYDPSWKKWTLEALPLIPQSFVHRVSRGKKDQFQVIRSLVHRKEVTEIVMAGDAGREGELIVRLILKQCRVKKKTSRLWLSSLTKQAVVSGFHQLKSAESTEPLYHEALSRSCADWLIGMNVTRAYTLLLKKKGVDSLFSTGRVQTPTLALIVKREKEIEAFESKPFWEVKATFRVQGHEYEGIWHKDRETRLFDQPMAEAIAAFCRGKQGKVTKVKKETKTLKPPYLFNLSSLQATANKRFTFSPKKTLDVAQKLYVKGHISYPRTDSSFLTAEEGKAAKRIVQLLKQEDAYASLFPLDRDNLLQDRRYVNQSKVTDHYAIIPTDDVPKVQTLAKDEQLLYDLIVRQFLAAHMREAKIAYTEVETLVDERATFLTKGKQLLDQGWKQIIGLSKDDKDEDIPPLEEGWTGDVKHADVREGKTKPPSRYTEGQLITLMKTVGKHVEDDELEKVLMRTEGLGTEATRAGIITLLKDRQYIEIKKNVVYATEKGKLLIEALGPSLLASPEMTAKWEQRLFEIGRGQADAHAFMEQVKKLSDHLVKEAHQRANTWDFSSFDQEALEEKTKKRKKRRPTYVGSCLACDGKLLDRGEFYGCTNYEAKSCRFTISKTILGKRLSQANVKKLLQGETTNVIKGLKKGSDTFDAKLYWDKEKKKLGFQPVES
(1137) DNA topoisomerase 1 [Bacillus halodurans C-125]
1
MADYLVIVESPAKAKTIGKYLGKKYTVKASMGHVRDLPKSQMGVDIEDEYSPRYITIRGKGPVLKELKSAAKKVKRVYLAADPDREGEAIAWHLAHSLDIDETSECRVVFNEITKQAIKDAFKSPRPINMDLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIDREKEIQAFEPEEYWSIQGTFALDGEPFEAKFYGTNGKKVELKSEDDVNNVLAKLKGDQFHVDSVQKKERKRNPVSPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKAETKEYIESKFGKEYAQNGTKAVKKDKKSQDAHEAIRPTSVERDPKSLKEYLSRDQLRLYKLIWERLVASQMAPAIMDTMTVDLSNEGVLFRATGSKVKFPGFMKVYIEGNDEGKKEEDRLLPNLQEGQTVTKEEIEPSQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQKRGYVALDERRFVPTELGEIVLELMTEFFPEILDVEFTAKMEDDLDSIEEGKQQWIKIIDDFYKGFEERLKVAEEEMKEVEIKDEPTGEMCEKCGHEMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPKCEKGEIVERKSKKRRVFYGCNQYPECDFVSWDKPIARSCPKCSSYLVEKRTKKQVQVQCSSCDYKEEAN
(469) DNA topoisomerase [Desulfitobacterium hafniense DCB-2]
7
MGKTLIIAEKPSQAREYAKTLGVKGKREGYFENDEYIISWCIGHLFELKAPENYMDLPKVGKRWSIRRLPVLPRLGEFQYGLKSGTAKQFKVLQGLLRSPEVQQVICGTDADREGQLLFQEVWDAVGSKKPLFRLWISSLTQEAIREGMSKLRPVGEVEGLAQAGYGRSYGDWDFGMNLTEGFTALFGSFDPVRKKPNVISIGRVQTPTLALVVEQEWAIENFVPVAYVEVEAEFASGQGSYKGKWFDPAVKNTRDKNQETDNAQMMLDLDRGKEIVAKVQGKPGRIRSVKDKETKEPHPLLFDLTSLTVSASKRYGFGAEKVLKIAQSLYEKKAITYPRTDCNYLPPDMLPKLKVHLQALEQSPFASWVKEALDNPLPGGKRVINEITAHHAIIPTTEKMIPNLSPDERKIWEMIVLRFLCIWFPPARYAEKEVVTVVEEEFFLTKGKTLLESGWKKIENTEKYTEGSGLQLPLLQQNEEVVTRSCQALQKETKPPKRYTQGDLIKAMEGAGKEIEDETLRRQLKGKGLGTVATRGAIIENLLDRGYLLQQQKVLVPTAKGTELIRLIKERLPRAQLLISAEMTGQMEYELAQVERGELPLSRYMEKVEEAIRGIIEELRHYEATRGKKPLAFAPQKAGASGRKSKSNLEEKPQELPVQAKVTKAAKTRQESPASAAEENLGICPSCGGGVVEREKGYGCQNWKNGCPFILWKNPICGKVLTPAQVKSLLKKGKTNLIKGFRSKNGSVFAAYLVWEDPSSGKLKFEFENNDRAKPG
(616) DNA topoisomerase 1 [Desulfitobacterium hafniense DCB-2]
1
MAKTLVIVESPAKAKSISKFLSNNYTVKASMGHLRDLPKSQMGVDVDNDFEPKYIAIRGRGDLIKELRAAAKTANKILLASDPDREGEAIAWHLGHLLGLDLAEKCRIEFHEITKPAITAAIKHPRQIDSSKVDAQQARRVLDRLVGYQLSPFLWRKVKKGLSAGRVQSVAVRLICDREEEIREFIPEEYWTLTASLKSEGGVFSAKLARKGEHRIAIASEEEMQKVLQELADQTYRVKDVRTKEKKKQPSPPFTTSSLQQEAHRKLNMSPKRTMMLAQQLYEGIELGKAGGIGLITYMRTDSVRISETAQEEAKEFIAEHYGADYYPPEPRQFKSKGRAQEAHEAIRPTSILRTPDSVKEFLSRDQLRLYRLVWERFLASQMSAAVLDTLTVEVEAGEYLFRANASTVRFPGYLAVYEDGQDENDDQEEGTLAANIQPDESLNVLQLQEKQHFTEPPPKYTEASLVRKMEEEGIGRPSTYAPTIETIQSRGYVAKEGKQLSPTELGEIVVSILKEYFPEIVDLEFTANMEKRLDDIEEGALPWKAVIRDFYGPFAESIEEADQVMGKVQIEDKVSEEICENCGRNMVIKMGRYGKFLACPGFPECRNTKPLLEEVGRPCPDCGNPLVIRRSKKGRKFYGCSTYPECEFVSWELPAPEPCPKCGGLMVVKTSKQGQKYVCTNSECRFDKQVEEQAE
(1667) DNA topoisomerase 3 [Desulfitobacterium hafniense DCB-2]
2
MGKSLVLTEKPSVGRDIAKLLGCNQKGNGCFIGSRYIVTWALGHLVTLADPEAYGEKYKQWRLEDLPMLPKDMELVVIKETSKQYAAVKQLLRQPDVEELIIATDAGREGELVARWIIGKAGWKKPIKRLWISSQTDKAIREGFNNLKPGKAYESLYAAAECRAQADWYVGLNVTRALTCKYNAQLSAGRVQTPTLALVVEREKEIQNFVPKGYWTINARVQGFSLSWQDKGNGQNRMFDQRKAEQLVQKLRGHKGQVAEIKKEAKREQPPQAYDLTELQRDANRKYGFSAKQTSSIMQQLYEQHKLVTYPRTDSRYLSEDIVPTLPERLKTIAVGPYSELARRVLRTKITPTKRLVDNSKVTDHHAIIPTEQTVFLNKLSPEEAKIYDLIVRRFIAVLSPAFEYEQTTVKVEIQGELFTAKGKIVKQKGWRSVYEGREAADEEADHEEQEQNLPDLQPKQTLEVLDLKLLPGKTKPPKRYTEATLLSAMEHPGQRVNDEALRETLEKTSGLGTPATRADIIEKLFSSFYMERNGKEIVPTSKGIQLIGLVPSELKSPELTAKWEQQLSEISKGREDRQRFIQGIKSYATQLVSEVSGSGRTYRHDNMTRAKCPECGKFLLQVKGKRGEMLVCQDRECGYRQGLSVQSNARCPQCHKKMKLQGEGEHKIFTCACGYREKLSAFNKRREQEGSKGSYNKREVNHYLQKQEKDAPLNTALADALAKLNLPK
(809) DNA topoisomerase 1 [Lactobacillus acidophilus NCFM]
1
MPTKAKSKSKTKKRKKILVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDNYKPKYISIRGKGDTIKELKSEAKKAKEVYLASDPDREGEAIAWHVAHALDLDENAKNRVTFNEVTKDAVKESFKHPRSIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWSIDAEFSKGKDTFKSSFYGIDGKKKELPNNDAVKEVLAKIDKRKNFEVENVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKEGTVGLITYMRTDSKRTSPVAQQEASKFLHENYGAEFAAKSQRHFKNQEDAQDAHEAIRPTSVYRTPESLKSVLTTEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVMFRTTGSKMKFPGFTKVYDNQQEKSVDLPDLQEGDKVKMTKSDNKQHFTLPPARYTEASLVRALEENGVGRPSTYAPTIDTIQRRYYVKLDGRSIVPTELGEIVDTLIEEFFPDIANVDYTAHLENELDEVEDGKKEWVHVVDEYYQPFKKELTKADSEIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKEIGVVCPKCGKGEVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKHSKKGPVVLCPNGDYKEEPQEGETDK
(276) Reverse gyrase [Caldicellulosiruptor saccharolyticus DSM 8903]
6
MATGAKYYHSCINCGGINSDTRNQKGLPCEKCLPFENNMNILESLKEHNSLKDYAYFWNFQNEYKEFEKFFVSKVGKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWMAKNGKKVALIFPTVSLVEQTHQRLLEFANKEPKENVKILSYKSSMKRTEKDEFEKNFENGEFDILIVSSQFISKRKDDLAKKVFSLVFVDDVDAILKSSKNIDTLLQMIGIDQKTIDKTFENLKKGVKYPEQKQNGTSSTPSKGILIVSSATAKPQGLKPLLFRELLGFEIGRFTFSVRNITNIRIAGKSKVKLLETIKILNDGILLFVENEEEGKDVTNFLENEGISVGKTWEDFEKSFEEFKDGKLKILCGIYSYYGKLVRGIDLPLRIKYSIFWGTPSFRFSTDIEKAPRFVLERVFSDYLEEHPKLKSFFKNIDKYQVERLREVVKKYIPQDRWTDFIKKSFSNLKISDEGQIFFPDVFTYIQGSGRTSRMLGSSLTKGVSILFEDDDLLFESLRSRLMFLLDEEWKTEDEVCFEDLIKEVEMSRNEALIDERSSDLKSRLMIVESPTKAETISRFLEKASTRRYGRLSVYESVTPDGILLITASKGHVYDLDTKTGVHGVEISNGNFIPYYNSIKRCTSCGTQFTDEYSSCPKCGSDKIDDKKEILKVLREIAAEVDEILVATDPDVEGEKISWDISQYLKPVNPNLRRIEMHEITKFGFESAIKNQRDFNANLVKSQIVRRIEDRWVGFELSSKLQKNFQSYNLSAGRVQSTILGWIIEREKEYAKSQKEFTFVRFENGFGFEAEGKIDGDKVLVDVVEENEKELETILPFNTPTLLSYASQKLNLSVQEIMEILQFLFEHGFITYHRTDSNRISLTGQNMARLYLEKIGKKDLFVGRSFGSEGAHEAIRPVKPISPLELKELSSERLAQGLTANHIKVYELIFNRFFTSQMKNPLVRYQKLIFRFDKQEIEKEMPIEVIEEGWLLFSPIQIFSKFESGEYQIIEKKNYKKHTTPLFTQAMLIDEMKQKNIGRPSTYAKMVEILFKRGYVFEDQYRRIRSTALGRKVYSYLAQHYQDYINEETTRDLERLMEVVEIGEKDYQSVLSSLYEELTKIMQR
(1148) DNA topoisomerase 1 [Caldicellulosiruptor saccharolyticus DSM 8903]
1
MKKLVIVESPAKARTIAKFLGKEFKVEASMGHIRDLPKSDLGVDVENNFAPKYINIRGKADVINRLKKSAQEAEKVYLATDPDREGEAISWHLAIILGLDQNDKVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIEKFKPEEYWTLEAVFKKDNQEFKAKFYGSKKGKLELKNQEQVDKIINQIKDKNFKVTKLKISEKKKNPPPPFITSTLQQEASRKLRFTPAKTMMIAQMLYEGVEIKGEGSVGLITYMRTDSTRVAEEAQEAARRIILQRFGKEYVPEKPRVYKTKKDAQDAHEAIRPTYIEKDPESIKDSLTPDQYRLYKLIYDRFLASQMESSIYDSLSAELEVEGYVFKLTGSKLKFAGFMEVYVEGKDTDEEEEENQLPEIFEGEMLKPIKLEKKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKVVTNILKEYFKDIIDIEFTAELEENLDRIEEGKADWVEIVRKFYLPLEKELETARNTMQQIKVDDEETDVVCENCGRKMVIKKGRYGRFLACPGYPECKNTKPYFDYLDVLCPKCGKKLIEKKSKKGKKYFTCESYPECNFIVWERPAKNCPKCNQLMFEKGKKRSKKLVCSNESCGYEEKIVEKGE
(1123) DNA topoisomerase [Clostridium phytofermentans ISDg]
7
MKVGKFMGKSLYISEKPSVAQEFAKALKSNFRKSDGYMESEDSIVTWCVGHLVTMSYPESYDPALKKWSLQTIPFLPKEFKYEVIPSVSKQFQVVKGLLNRSDVDKIYVCTDSGREGEYIYRLVDQMAKVPKNKEKRRVWIDSQTEEEILRGIREAKPLSDYDNLSSSAYLRAQEDYLMGINFSRVLSLKYGYTVNNFLKNEKHSAIAVGRVMTCVLGMVVRREREIREFVKTPFYRVMLTLETSDRTFDGEFKAVEGSKYYLSPLLYKENGFREKQEAEKLITMLTGYESEYETRIENNNKNSYLAKLKQDEESKQLVAEIVSMEKKKENKNPPLLFNLAELQNECSKLFKISPDETLKYTQELYEKKLVTYPRTDARVLSTAVSKEIYKNIKGLTALSQFQPFAEEVLALGSYKNIAKTRYVNDKQITDHYAIIPTGQGFGALSSLSPTAKRVYVSIVKRFLSIFYPPAVYQKIAITTKIDTESFFSSFRVLIEEGYLKVAGYQGNTNTAMQDTDGSAKTSTKTEADGKEKGSDEETEEEKDYDATFFEVIKSLKKGMKLPVRNFTIKEGETAPPKRYNSGSLILAMENAGQLIDDEELRAQIKGSGIGTSATRAEILNKLVKINYLSLNKKTQIMTPALMGELIYDVVNVSIRSLLNAELTASWEKGLTMVSDGTITKDEYIAKLEGFVGRMTEGVKGVNNANLLIPYFEQVAQNYKK
(376) DNA topoisomerase 1 [Clostridium phytofermentans ISDg]
1
MPKYLVIVESPAKAKTIKKFLGNNYEVLASNGHVRDLPKSQMGIDVENGFEPKYITIRGKGDLLAKLRKEVKKADKVYLATDPDREGEAISWHLSQTLKLDDKSASRITFNEITKNAIKNSIKEARDIDMNLVDSQQARRMLDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREEEINDFVPKEYWNLDASFKVKGEKKSLVAKFYGDTKKKISIESKEEMDKILADLKGAQFKITEVKRGERQKKSPLPFTTSTLQQEAAKLLNFSTQKTMRIAQQLYEGVDVKGHGTIGLISYLRTDSIRVSEEADTAAREFIKTQYKPEYVNSQDVNKTTGKKIQDAHEAIRPTYVDLTPVIVKESLSREQFRLYQLIWKRFIASRMQPAKYETSTAKIDGNGYRFTVASSKLIFDGFMAVYASEDEEEENTTSNMMSLSEETQLTFEEFNSSQHFTQAPPHYTEAALVKTLEELGIGRPSTYAPTITTIIARRYVIKENKNLYVTELGEAVNRIMKQAFPTIVDVNFTVNLEALLDGVEDGVVNWKTVVSNFYPDLESAVQDAEKQLEQITIEDEKTDVICSECGRNMVIKYGPHGKFLACPGFPDCRNTKPYFEKIGVACPLCGSDIIIKKTKKGRRFYGCENNPECEFMSWQKPSGKLCPICNGIMVEKGQKLVCVNEGCGHVENKEQN
(1399) DNA topoisomerase 1 [Desulfotomaculum acetoxidans DSM 771]
1
MSTTLVIVESPAKAKSIGKFLGKKYTVKASMGHVRDLPKSQFGVDVEAGFMPKYITIRGKGDTIKELRSAVKKADTVLLASDPDREGEAIAWHLQKLLKIEDNQPCRIEFNEITKQAIQNAVTHPRKIDYNRVNAQQARRILDRLVGYNLSPLLWRKVRKGLSAGRVQSVAVRLICEREEEIDSFEQVEYWTLTGKFLKAKAGFEGKLLKYRGEKLEVSDEESMQKILQALEGSSYVIEKVSRRERSRRPAAPFTTSSMQQEAYRKLNFTARKTMVVAQQLYEGLDLGKEGSTGLVTYIRTDSTRVSGTAKEEAKEYIDKQFGQAYTGEQDGEIKGQKERKIQDAHEAIRPTSVFREPDQVKKFLTPEQYKLYRLIWSRFVASQMSPAIIDTTSVDIAAGEYTFRSAGSIVKFSGFMKVYTEGNDDGQKEEIKTLPELAEGEKLELTELLPKQHFTQPPPRYTDASLIKLLEENGIGRPSTYAPIVETIQKRGYVSRENKQFFPTELGFVVVEMLKEHFPEIIDVEFTADMEKKLDHIEEGDTDWIKILEEFYGPFHETMEKAEEAIGKIELQDEVTEEICELCGRNMVIKFGRFGKFLACPGFPDCRNTKPLLEPTGVTCPLCSGEVVLRRTKKGRKFYGCSRYPECDFVTWDLPTNEKCPSCNSMMVKKSSKNKQMLSCVNQECKLKIEMSEDKK
(48) DNA topoisomerase [Desulfotomaculum acetoxidans DSM 771]
7
MKQLVLAEKPSVARDLSNVLGNFNKGNGYLESDAYIITWAIGHLVTLAEPDDYDAALKKWFLNTLPILPREFKLKPVSATLKQFNIVKSLLHRNDVGDIICATDSGREGELIFRYIYKLTDCQKPFKRLWLSETTPAAVRKGFDNLRPGNDLDRLAFAAEARSQADWLIGINATRAFTVKHNQLLSVGRVQTPTLALIVNREQEIRAFVPEKYWELFALFTKENGQTYIGKWFKKEKKAVENWEIPIQVGQKQTNQNPAASFEAAQGGIPSVMGEAVPSSNGQDKPVAMQTKFAAREAARDIQKKVTGQPGQVVSVEKKDIIEHPPLLFNLNDLQKEANKKFGLSAAKTLSVAQELYESRKLITYPRTDSRCITVEMGKTIPQRLGALAVVAEYENFIHLIKERKAFLNKRYINDSKVTDHTALIPTNVKPDLDKLSSDERRVYDLVVRRFLAAFFPPARYEQTQVITEVKQETFLSRGRVELDKGWKTVYDPVQDKLVDDEQGILPVIENEESVLTTKTDIKEKKTNPPKRYTEAALLSVMEGAGRLLNDEELKEAMRGSGLGTPATRAAIIERLLKVGYIERRKKTLLPTEKGENLIKLVPEQVKSPEMTARWEKALADIEDGQLNPGEFMSGIIEQTRQVVELARRQKTEGEPLRNNRDIIGKCPLCGRPVVEYPKSYSCSDYRAGCQFVIWKVILGKNITVEMARILLEKGRLEKQPGFISKNGKKFDAPLIIRNGRVEFDF
(1746) DNA topoisomerase 3 [Desulfotomaculum acetoxidans DSM 771]
2
MKSLVLAEKPSVAREIARILNCTIKGKGYLEGNKYIVTWALGHLVTLAEPEDYDEKYKTWRTEDLPMLPAEMKTVVIKKTGPQFHIVSKLMKRPDVRELIIATDAGREGELVARWIMKQARCQKPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAICRAEADWLIGLNVTRALTVKYNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANLGKFQAEWRDKSGKHNRFSDCLQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLTELQRDANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGYFAELVKPLTAKPLPINKRLVDNSKVTDHHAIIPTTERANLAALTAEEKNIYDLIVRRFIAVFYPAYSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNLPPLKKGDKVKVLSCKSVKGQTKPPARYTEASLLSAMEHPGKFIEDEILKESVKESGLGTPATRAEIIEKIISSNYVERRGKELIPTAKGIQLVELVPPELKQADLTAKWEQQLHDIAMGKSKRTKFISGIREHAEKIVTTVLNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRGSNLVCPDRSCGHRQVEKETSNRPCPQCKKRRMEIREGKGGKIIVCTHCRYQEKYVLQPKREAKVNIKAYSDSAPLVTNLSILANFKFNGAKEKSD
(903) DNA topoisomerase 1 [Eubacterium eligens ATCC 27750]
1
MHKYLVIVESPAKVKTISKFLGANYKVMASQGHVRDLPKSQMGVDIEHDYEPKYITIRGKGDILAALRKEAKKADKVYLATDPDREGEAISWHLAAALKLEDKDIYRITFNEITKNAVKASLKEARKIDMNLVDAQQARRVLDRVVGYGISPLLWAKIKRGLSAGRVQSVALRMICDRENEIDEFIPEEYWSMEAVLNIKGEKKPLIAKFYGDENGKIEIKNGAQMQDILDEVKKSDFSIESIKRGEKVKKSPLPFTTSTLQQEAAKTLNMSTKRTMNIAQQLYEGVDIKGRGTVGLITYLRTDSTRVADEAKVSSREYISQNYGEKYIPQEANAKKDDKKIQDAHEAIRPTDLNLSPAIVKESLQRDQFRLYQLIWKRFVASQMAPAVYETTSVKIMAGKYRFSVAASKVMFDGFMSVYKNDDDNEENNTLAKGLDENSELSLEDVNGVQHFTQPPAHFTEASLVKALEEQGIGRPSTYAPTISTIIARHYVIKENKNLYISELGNAVNNIMITAFPTIVDVKFTANMESLLDGVAEGTVEWKEIIRNFYPDLKVAIDEAEKELEHVKIEDEVTDVICDKCGRNMVIKYGPHGKFLGCPGFPECHNTKPYLEKIGVPCPKCGKDVIIKKTKKGRTFYGCDGYPDCDFVSWQRPSEKKCPKCGGYMVEKGNKIVCADETCGYVENKNDKEQ
(391) DNA topoisomerase [Eubacterium eligens ATCC 27750]
7
MLQENNNCVIDTEMRDIMGKSVYIAEKPSVAQEFAKALHVNFTRKDGYLEGGDHIVTWCVGHLVTMSYPDAYDPNLKRWSFDTLPFIPKEFKYEVIPAVAKQFNIVKDILTRNDVEYIYVCTDSGREGEYIYRLVRQEAGVKGKKERRVWIDSQTEEEILKGINTAKDISEYDNLSDSAYLRAKEDYLMGINFSRVLTLKYGRNIANYLHLDRAVVSVGRVMTCVLGMVVRREREIRSFVKTPFYRVIGQAQVENSTFDAEWRVSDKSMYAGTPYLYKDNGFKDREKAEELVKFLSDPLPAQGVVDSIERKKETKNPPLLYNLAEIQNECSKLFKISPDETLNIIQELYEKKLVTYPRTDARVLSTAVSKEIHKNIGGLRNFPPVKEIAEHILQNNMQKGIEKTRYCNDKAITDHYAIIPTGQGFNNLKNLSVTAARTYEIIVRRFLSIFYPPAIYQKVSIISDVKNEKLYASFKVLVDEGYLSVAKNSFAKARNDAKVKDDDSVDNKEDNKCDVALFEVLKKYRKGSTITFNGFNIKEGETSPPKRYNSGSIILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLNTIKYISINSKTQIITPTFLGEIIYDVVDNSIRHLLNPELTASWEKGLTGVAEGNITADEYMEKLDGFVSRRTRAVMALRNQVGLVGLFNETAKNYK
(1254) DNA topoisomerase 1 [Anaerococcus prevotii DSM 20548]
1
MAKNLVIVESPTKARSISKMLGRNYKVMATVGHLRDLPKSKFGVDIENNFEPEYIKVRGRAKTINELKKEAKKAENVYLATDPDREGEAISWHLQFLLDLDPEAKNRVEFHEITKENVKNAIKNPRKIDQNLVDAQQARRVMDRIVGYEISPILWKRVKAGLSAGRVQSVALKLIVDKQKEIDDFVPEEYWTITAHHKEGREKFDSEFYGQINKKIKISNENGADKVLNKIDKDKFEVVKITKTKKRRKPQKPYTTSTLQQDASNRLGFSTRFTMQLAQQLFEGIDVGDGSVGLITYMRTDANRISKEIVGEALSYIKEKYGPEYAGKGNTYGGKKKGSQDAHEAIRPTSIRRNPLEIKEYLTDQQYKLYKMIWERVVASQMTDYEFLSTQVLFDNNSLIFKTNGKITLFEGFNKLGANKENENILPELKEGDVISAESIDKDQHFTKPPARYTEASLVKTLEEFGIGRPSTYSATINQIISRNYVELEGRSIFPTDLGKTVNTFLQENFDDVINVEFTREMEDALDNIAEGDRFWKETLKSFYKDFEKDMKGVKKDGKDYKVRDEILEEKCPKCGKPLAIKHGRNGKFIGCTGFPDCNFTKSIVKSTGVKCPECEDGTIIEKVSKRGKRFYGCDNYPKCDFALWDPPTGEKCPECGSLLIHKKNRSTDEIKCSSCDYVKEKRR
(853) DNA topoisomerase 1 [Halanaerobium praevalens DSM 2228]
1
MAKKKKKLVIVESPAKAKTIKKFLGKDYKVEASMGHVRDLPKSKLGIDLESDFEPNYITIRGKGKTLNKLRKAAKKSKEVYLATDPDREGEAISWHLAYALKLSDQENNRIEFNEITKNAIQNAIKNPRNINKDLVDAQQARRLLDRIVGYRLSPLLWKKVRKGLSAGRVQSVAVKIICKREEEIRDFDEEEYWSLEVELKNDENQTLKADLYRIDNKKYNLATQEEVEQVVEAIKKEEFEIIKVKKRKRKRNPKSPFTTSTLQQRASTKLNFTAKKTMYIAQQLYEGIDIGSSGTVGLISYIRTDSTRLSNEAKKGAKDYILAEFGTDFLKKKKEKSKKNANAQDAHEAIRPTDTQRTPEKIKKHLSKDQFKLYDLIWKRFIASQMSSALYQNISAQFKVGEKYKFRVSGSRLLFPGHLILTGKEKEKDIDLPVLTEGEKYKLIKTNPEQHFTTPPPRFSEASLVKTLEEEGIGRPSTYAPTLSTIESRDYVKKEGRYFEPTELGETVTKLLTEYFPDVTDVEFTAELEKNLDEIENGNKDWKQILRDFYEPFYQRLENARENMESVNIVEETDEVCDKCGSPMVVKYGRYGKFLACSSYPECKNTKPYLVRTGVDCPDCEEGEIIERTSKKGRTFYGCSNYPDCNFMVWNKPVEKPCPKCKSLMVEKTTKAKGKHHKCTNKECGHIEKVD
(1638) DNA topoisomerase 1 [Thermoanaerobacter mathranii subsp. mathranii str. A3]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFTPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNFTKFEAKFYGTKEDKVELKTKEDVDKVLAALSEEYTVDKIKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYANPGANYASKKANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDIQEEEEKTVPVLQEGTKLLLKELKPTQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDNKNLKPTELGFIVTDALKEFFTKIVDVKFTAEMEEQLDKIEEGQAKWYEVVQEFYNDFYKTLKIAEEQMEEIDIKEEVEVTDIKCEICGRPMVIKKGRYGKFLACSGFPECKNTKPLYEKIGVKCPKCGGEIVRKKSKKGRMYYACENAPNCDFILWDKPVEEKCPVCGSLLIEKNTKNIHILKCSNAECDYQKEVK
(651) DNA topoisomerase [Faecalibacterium prausnitzii SL3/3]
7
MVGINASRLFSCLYNQPLAVGRVMTPVLAMTVVREAAIAAFTPEKFYTVDLELTSGCTASSRRIPEKSVAENLLKACRKEMVATIQRITRKEKSENPPPLYDLTTLQRDANRLLGYSAQQTLDYVQSLYEKKLTTYPRTDSCYITDDDEEMLEELTEELEGFLDITSADVDEAVPRTRRTVNREKVTDHHAILPTRSMLQADLDALPKGEQNVLKLIIARTLMAVSKPFRYLETLLTTECAGEEFTAKGKEILEEGWKAVERKVLADILNRKQELTALPNAAENEYGILNAELKEGQTSPPKHFTEDTLLHAMETASADSMPEGVERQGIGTPATRAATIEKLVQKGFLERKGTKKTKVLLPTDKGKALITVMPEEIQSADMTADWEAKLLQIERSEMEPETFMTEIKEMISSLVTTTEAAKGANALMKNKIIGVCPNCGANVVEREKGWFCESNPCRFVLWKDNAFFKRLGKRLDGRMADKLLRDGHVRLKDCKSAKGKTYNATVLLSTEPDGRSKFSLEFEGGC
(1511) DNA topoisomerase [Faecalibacterium prausnitzii SL3/3]
7
MEDAAIREGFANLRPDSDYDALYQSALCRAKADWLVGINATRLFSVLYHKTLTVGRVQTPTLKMLVDRDAKILRFQKEKYYTVGIQSGSLKAGSGRIADAETANSLKEKCTGTTTVCTSVKREKKTEQPPKLYDLTTLQREVNRLFGFTAKQTLDYAQQLYEKKLLTYPRTDSQYLTEDMGQTVRHLVSDLLGLLPFAQRLVLTPDVSRVLNSNKVSDHHAIIPTAEFAKQGFTGLAESECKLMNLVCSKLLCAVAIPHEYETVTAVFSCAGNEFTAKGKTVLVPGWKEIDQRFRSTLKADTEEEVLNTLPELAEGQSFSVTANVSEHFTSPPKAYTEDTLLSAMEWAGAEDMPEDKVNCSAGAREGGLGQAERKGLGTPATRAAILEKLVQIGFVQRKGKQLVPTKDGINLAVVLPESLTSPALTAEWENRLTEIAKGNADPDEFMAEIEAQVHQLVKTYSCISADKQNLFQSERVIIGKCPRCGENVYDGKKNFYCGNRGCQFVMWKNDRFFEQRKKAFTPKIAAALLKNGKAKVKGLYSEKTGKTYDATVLLADTGGKYVNYRVERKE
(1654) DNA topoisomerase III, bacteria and conjugative plasmid [Faecalibacterium prausnitzii SL3/3]
7
MRYKLVIAEKPSVAQSLAAVIGATARKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGEMIFRSVYELADCQKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPVPFYTVALELPGLTVSGERMSDRASAEQMKEACQDAAVAIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVANAMPFCKEIAITCDPHTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACADGEFTAKGKTVKHPGWKALEDACRAKMKDAEPKKEGAEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLSAMETAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIEHGQLAPEEFLAGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQSKECRFAIWKNNKWWTAKKKQPTKAVVSALLKDGCVRVTGLYSEKTGKTYDATVVLEDDGQYANFKLEFDQRKGGSR
(1214) DNA topoisomerase 1 [Faecalibacterium prausnitzii SL3/3]
1
MAKLVIVESPAKAKTIGKYLGDDYEVTASMGHIRDLPASQLGIDVEHGYTPQYISIKGKEKLIKELKSKAKHADGVLLATDPDREGEAISWHLANILGLDPHEPNRVTFDEITKKGVKEGMAHPRAIDEDLFNAQQARRVLDRLVGYKLSPFLWRKVRRGLSAGRVQSVAVRLIDDREKEIENFKPDEYWNVDATLGAGHKSFVARLATDANGKKLLPKSEAEARAIEKGLEGASYVVSELKRGKRAKQPTPAFITSTLQQEASRRLGFTATRTMRAAQTLYEGVDIAGHGMMGLITYMRTDSLRISDEAVAAAKEYIAGAYGEAYICPYKRTWKTKSATAAQDAHEAIRPSVPSLTPDEVDKSISGDTAKLYRMIWSRFMASQMADCQQDTVSVTVSAADYHFKASGYTVTFDGFTALYEEATDEKEKKETNLPPLEQGQVLKLRELKSEQKFTQPPARYTEATLIKALEENGIGRPSTYAPIITTIIDRGYVERDQKKLKPTLLGRAVDGLMLEQFPHIVDVDFSAQMEKNLDKVESGKADWRKTVDDFYQGFEASLEQAEKNMEGKKVKVPDEPSSEVCDLCGRPMVIKVGKYGKFLACSGFPECRGTKRLVKDTGGICPKCGKGRLLERKSSKGRIYYGCECYPDCDFMTWDMPVATKCEKCGSTLFRKGGKLYCAKEGCGFEMPVPKKD
(329) Topoisomerase IA [Ruminococcus bromii L2-63]
2
MAFRLVIAEKPSVAQTIAAALGIKGKQDGYIEGGGYLISWCVGHLVQLAEAAAYGEQYKKMEF
(1286) DNA topoisomerase 1 [Ruminococcus bromii L2-63]
1
MSDLVIVESPAKAKTIKKYLGSGYEVVASMGHVRDLPKSRLSVDIKKNFAPKYEIIKGKEKLVDDLKSAAEKSEHIYLATDPDREGEAISWHLAYILGLPTDETNRVEFNEITKSGVTNGMSNPRSINIDLVNAQQARRILDRLVGYKLSPFISQKIRRGLSAGRVQSVAVRIIVDREEEIRKFKPEEYWSIDAKFIPKGSRKSFSASLYSDENGKIKITNGEQADKIEADLQNAEYVITKVKNGTRKKSPAPPFITSTLQQEASRKLGFQSRRTMKVAQELYEGVDIEGMGATGLITYMRTDSLRISNVAIEEVTEYIKNSYGEKFLPPKPRFFKSRSNAQDGHEAIRPSMPSLTPDSVKASLTSDQYKLYKLIWNRFTASQMADCIQKTTQADIVANGYTFKASGYRVDFEGFTTLYVESKDVEEEKTTQLPPLEKDMIVRCKELKKNQHFTQPPARYTEASLIKALEEYGIGRPSTYAATITTITSHEYVKREGKSLVPTELGEVTTNLMKERFPKIVNVKFTNQMEEDLDKVEKGTEEWHALLDNFYGDFDKTLKKAKADMEGVKLHLKEDETDIICDKCGRQMVVKVGRYGKFIACPGYPECKNIIKYVEKTGVKCPKCGGDVIIKRTKTKRIFYGCSNYPECDFVSWNEPTNEKCPQCGGILFKKKGKKPTLFCATEGCGYTKTADTDDK
(34) DNA topoisomerase [Ruminococcus bromii L2-63]
7
MKLVIAEKPSVGAAIAAVMGANEKRSGYFEGGGYLVSWCIGHLISLADAATYNEQFRKWKYDDLPIVPQEWQFIVASGKEQQFSILKDLMHRSDVTEIINACDSGREGELIFRFVYEQANCKKPFSRLWISSMEASAIREGFSNLKDGRGYDNLYQSALCRAKADWLIGINATRLFSILYHKTLNVGRVQTPTLAMLVNRDYAISSFKKEKYHVVRLDVGGVAALSERQDDEAAARQMKAACEKSQAVCTSLKKEKKTAAPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYPRTDSKYITSDMEGSTKELITGLCAALPFMQGVKLQADLARICDNSKVTDHHAILPTAEFVKTGFSSLAESEKKLMTLVCAKLLCAVAAPYEYEAVTAVFTCGGYTFTAKGRTTLCEGWREIERLSRAASGEQDEDAEPEAVLPPLAEGQTFDNPAAEISERYTQPPKAFTEDTLLSAMESAGKEDTPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLVAILPDSLTSPQLTAEWETRLTGIAKGSDSPADFMRGIEEMTAGLVKTYSAISEDKAKLFTPQREAIGTCPRCGAAVYEGKKNFYCSDRACSFVMWKNDRFFEQRKKAFTKAIAAALLKDGKVKIKGMYSTKTGKTFDGVVLLADTGGKYVNFRVEQNRK
(92) DNA topoisomerase III, bacteria and conjugative plasmid [Ruminococcus torques L2-14]
7
MAQHKLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGELIFRSVYELAGCKKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFQPVPFYTVALELPGLTVSGERMADKAAAKQLKETCRGANVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTSDMADSLPVLVNLVANAMPFRKGIAITCDPQTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACAGGEFTAKGKTVKHPGWKALEDAYRAKMKDAEPKKEGAEKALPELTEGQTLSVAAAIVKEGKSSPPQHFTEDTLLSAMETAGKENMPEEAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIERGQLAPEEFLDGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQNDSCKFAIWKNNKWWDAKKKQPTKAVVSALLNDGCVRVTGLYSEKTGKTYDAAVVLEDDGQYANFKLEFDQRKGGSR
(644) DNA topoisomerase 1 [Ruminococcus torques L2-14]
1
MAHYLVIVESPAKVKTIKKFLGSNYTVAASQGHVRDLPKSQLGIDVENDYEPKYITIRGKGEILATLRKEAKKSDKVYLATDPDREGEAISWHLAAALKLDEKKMRRITFNEITKNAVKASLKAPRDIDMDLVDAQQARRELDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIVADREAEIDAFIPEEYWSLDAQLKVKGEKRPLTAKFYGTEKKKMTIHSKEEMDEILKKLENEEFQITDIKNSERTRKAPLPFTTSTLQQEAAKALNFGTQKTMRIAQQLYEGVDIKGNGTVGVITYLRTDSTRISEEADAAARSYIAETYGEAYVAEGTKTKSADKKIQDAHEAIRPTDITRTPAAIKDSLSRDQFRLYQLIWKRFTASRMQPAKYETTAVKIGAGEYCFTVSTARVAFDGFRSVYVEAEEEKEESNVLVGHLSMDSVLTKEEFDPKQHFTQPPAHYTEASLVKTMEELGIGRPSTYAPTISLILGRRYITKEGKNLYLTEIGEVVNNIMKQSFPSIVDVHFTANMEGLLDMVEEGKVPWKEVIRNFYPDLEEAVEIAEKELEEVKIEDEVTDVICEECGRNMVIKYGPHGKFLACPGFPECRNTKPYLEKIGVPCPVCGKEVVIRKTKKGRKYYGCEDNPECEFMSWQKPSSKKCPECGGYMVEKGNKLVCADEKCGYVETIKKED
(489) DNA topoisomerase [Ruminococcus torques L2-14]
7
MGKSVYIAEKPSVAQEFAKALKLNTKRRDGYLESDEAIVTWCVGHLVTMSYPEEYDPALKRWNLQTLPFIPEEFKYEVIPSVAKQFQIVSGILNREDVDTIYVCTDSGREGEYIYRLVEQEAHVEGKKRRRVWIDSQTEEEILRGIREAKDLSEYDNLGASAYLRAKEDYLMGINFSRLLTLKYGNSISNFLQTKYSVISVGRVMTCVLGMVVRREREIRDFVKTPFYRVLSTIDAQGHTFEGEWRAVKGSRYFESYDLYKENGFKERKKAEELIQYLQTPDDESVNVAGIQRQLGLNCRIESIEKKKEKKNPPLLYNLAELQNDCSKRFKISPDETLRIVQELYEKKLVTYPRTDARVLSTAVAKEITRNLNGLSKYPMAAPYMQDILNFGSYKTLAKTRYVNDKQITDHYAIIPTGQGLNALSTVSSTAKGVYDLIVRRFLSIFYPPAVYQKVAIVTKIKEESFFSSFKVLAEEGYLKVAGIPKKKASQTATKDSSNGNSENTNNDTNDEAGSDSSDQSLDTGLFEVIKSLKKGAVLQVRALDIKEGETSPPKRYNSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLVNIKYLALNKKTQVITPTLQGEMIYDVVDHSIRSLLNPELTASWEKGLNYVAEGSITSDEYMRKLDHFITSRTVGVKGLNNQYQLRACYEKAAGFYPSVNNNKTIGRTKTGNKSK
(473) DNA topoisomerase III, bacteria and conjugative plasmid [Eubacterium siraeum 70/3]
7
MMRYKLVIAEKPSVAQSLAAVIGATARKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGEMIFRSVYELADCQKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPVPFYTVALELPGLTVSGERMSDRASAEQMKEACQDAAVAIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVANAMPFCKEIAITCDPHTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACADGEFTAKGKTVKHPGWKALEDACRAKMKDAEPKKEGAEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLSAMETAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIEHGQLAPEEFLAGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQSKECRFAIWKNNKWWTAKKKQPTKAVVSALLKDGCVRVTGLYSEKTGKTYDATVVLEDDGQYANFKLEFDQRKGGSR
(1507) DNA topoisomerase [Eubacterium siraeum 70/3]
3
MIVIYAEKYSLGRTIAEALGAYKKTVNPKEPSIAHWSLNLNGEEAILCHGAGHLCGLAPAEDYNESYKFWSFDNYPIIPEHFITRVKDNNYSRLAYDYVKQFFDKADLIINATDADREGELIFAYLYEVLHCTVPYKRVWITDLTPFKIRKAFAELRPAKDMKPLENAGRIRSATDWLVGINTSVAATLKFGGTDNVFACGRVKMPTLAMIVKREREIRNYVKKPFYKIVANIEATDGAKFTAEAADKYDTETAAKAVIDEIKLNTAKAIKVEVLQKQTAAPLLYNTTHLLADLSKCTDLTIDMLTKLVQSLYENRLITYPRTSSEHLTDAMKDETVKIIKLLFEMPEFAKYAIPVDNFAPCTRRHYDDSKVDSHTAITPTALVPNDLSGMSENERKAYTLLALSIIRTVYPKAVTENVKAVFQIDNQLFTATGTNIISPGWFAVDATPKVIGLPEIVKDNDYKVIGFDVKEGQNEPPKYYTDATLLTAMELAGDNIEDEQTRNLIKLEKRGLGTAATRQGIIKELYEKGYIARRTKKNGNMIKGIMPTEKGMYIIDALEKTVPDMLSVDMTSDMEMELDKIARGKSDGNDFLNNYKKLVAKWVELIKNSDTSAMAGNTLICPLCSKPLIKKKVGWCCTGYSKDNPDSCRFYIANEICGKKISDVIAKELTLKRSTSIIKGFTSQSGKTFDAKLTIKADNTIGFEFPERLKCPVCGKEMIKSSKGWVCTGYKNGCNFFIAGTICGKCITDTIATMLCANKRTRIINGFTSKSGKAFSAALIVKDGKIDFDFPAQSQKRSK
(1780) DNA topoisomerase 1 [Mahella australiensis 50-1 BON]
1
MANNLVIVESPAKAKTISKFLGRGYKVEASMGHVRDLPKSQMGIDIEHGFEPKYITIRGKGEIVDKLKKQAKAVDRVLLATDPDREGEAISWHLAQLLDIDMDKACRIEFHEITKNAIKDALKHVRPIDKNLVDAQQARRVLDRLVGYSISPLLWRKIRKGLSAGRVQSVALRLICDRQQEIDNFVPQEYWTLTALLASDKGETLEARFYGKDTKKQELKDKESVDAIIKDINGSDFIVEKIERGQRKRKASAPFVTSTLQQEAARKLRFTAKKTMAVAQQLYEGVELGKEGMVGLITYMRTDSVRVSQEARREARNYIAERFGDNYVPDKPNEFRNRKGTQDAHEAIRPTYINYTPDYVKSFLSRDQYRLYELIYNRFIASQMSDAVYDTISVTIKAGDYVFKASGSTLIFPGHLALYMEGQDDDNDDKEQKLPPLEEGQRLILKKWMPEQHFTQPPPLYTEASLVKMLEEKGIGRPSTYAPIISTIVERGYVVREKRTLKPTELGILVNDMLKEHFPDIVDVSFTAQMEQMLDDVEEGQKDWHNIISEFYFPFKSVLDKADQSIEKVDVPDEQSDVICEKCGRRMVIKQGRYGKFLACPGFPECRNTKPLLEELKVTCPKCGGHIQIKRSKRGRKFYGCENYPKCDFVSWDEPTGELCPECGYPVVIKYSKNGRKYTRCSNKDCKYTGQKLAGEAK
(379) DNA topoisomerase 1 [Weissella koreensis KACC 15510]
1
MPTTTKDKPKAKKRTTTKRKKNLVIVESPSKAKTIEKYLGSGYKVVASIGHIRDLPKSQMGVDTENDYNPKYINIRGKGDVIKNLKKEAKAAKHVYLASDPDREGESIAWHLAHILDLDTSSEENRVVFNEITKDAVKDAFKRPRQLDMNLVNAQQARRILDRLVGYSISPLLWKKIKKGLSAGRVQSGALGLIIDRENDIQAFQPEEYWELPAEFKKSNKKFKAGFYGLDGQKVKRIPDNEMVQSILKRIDQNQEFDISEVVKSEGKNNPSPAFTTSTLQQAANTQLSFQTRRTMSTAQQLYEGINLGGKEGSVGLITYMRTDSTRISSIAKNDASKFIHEEYGDEYAATKPVQGKLQEGAQDAHEAVRPTSVFRTPKSIKDKLTNDQFKLYQLIWSRFVASQMTAEVIDRVRVTLTQNGVMFRANGATTKFAGYTKAYPAAKAKDNVLPEMVEGGNVKLDKINPEQKFTQPKPRYTEAALVKALEEAGVGRPSTYAATIETLKSRAYVKMDAKKFIPTEIGKMVQDAVRDYFPDVADLKFTAQIEGELDNVETGNEDWVKVVDEFYKPFKGELDIAESEMEKIVVKDKLAGENCEICGAPMLERLGRYGKFFACSRFPDCRNTKTIVKEIGLVCPKCHQGQIIERKTKRGRTFYGCSRYPDCEFISWDKPTEKTLADGTTPKDGEDNKKSKTTKSKKPATKKATKKKAAKK
(5) DNA topoisomerase [Weissella koreensis KACC 15510]
7
MRTIILAEKPTQAVAYSKAFKSSKKREGYIEVSNEYFDGETYITYGFGHLVELYLPEQYDEKYKNWSINNLPIIPDQFKFKTGKGKAEQFKIVKNLLSEADQIIIATDADREGENIAWSIINQSGINPQEKIMKRLWINSLESSAIRDGLTNLHEAKQHYSAYIEAQTREFSDWLVGMNASPLYSLSLRKQGIRGVFSIGRVQTPTLYMIYKRQVEIDNFKPKPYIELLAHVKTGKSEFEAKLDPFIRFDNQDKVKVFLSDNELVLVNKSQSKENNNNFGIINNIIKDKKKQPSPKLFSLSTLQSRANKAFKASAQNTLDAVQSLYEKKFLTYPRTDTQFISDEEFSYLLDNINQYCEFANVTANIAHKEPRKRYVNSKKVQEHHAIIPTRTIPTKNQFMKLTSLEKSIYELVLRTTIAMFLDDLNYDEQVIIVKSGQAQFKAMGRVITTPGWKLLFKTNSKKSSANGEVSLPRVDIGQKVDFDLLDEHKVTVAPSAYTEGTLITAMKNAGRDLADAQKEILKETEGIGTEATRAGIIERLKAKSYIELKDNSLAVTMSGIILCQAVELQPLLNSPELTAQWEMALHEIGQNNRTQASFLKQIEKFILKLINEVPDQIETNQKLTDQINSQKDTNADQYKEHMGICPVCKAGHMIDRGKFYGCSNYNSKEACNFSLPSKWAGKILPKTAIKDLIKKGHTKEISGFKSKAGKSFSAILELVDGKLKFVFDK
(1103) DNA topoisomerase 1 [Staphylococcus haemolyticus JCSC1435]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDVEDNYEPKYITIRGKGPVVKDLKKYAKKAKNVFLASDPDREGEAIAWHLSKILELDDSKENRVVFNEITKDAVKESFKHPRGIEMDLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKSKFTAKFLHYKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISQTAKDEAKQYIEDKYGKDYLSNRTAKGKQGDQDAHEAIRPTSTLRTPYEMKAYLTRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNNIKFRANGQTIKFKGFMTLYVEAKDDKDNEKENKLPNLSKGDEVTATQIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVYEQVKDYFPEIIDVEFTVNMETLLDKIAEGDIGWRKVIDNFYGSFKLDVERAEEEMEKVEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPKCKDGDVVERKSKKNRLFYGCSNYPECDFISWDKPVGRDCPKCNHYLMEHKKGRSSQVICSNCDYKEEVQK
(976) DNA topoisomerase 3 [Staphylococcus haemolyticus JCSC1435]
2
MKSLILAEKPSVARDIAEAMNIKGKRNGYIENEKYVVTWALGHLVTNAQPEHYDKAYKEWKLEDLPIIPKRMQTVVIGKTSKQFKTVKSLILDKKVKEVIIATDAGREGELVARLILDKVHNKKPIKRLWISSVTKKAIQEGFKKLKDGREFQHLYEAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVNARQQEINHFKAKKYYTLSTEIGGLTFQLSTNKQHMTMEDATQIANEIKHVEGNVDSVEKKVKKSHPKPLYNLTDLQQEAYQRYKMGPKETLNTIQNLYERHKVLTYPRTDSNYLTDDMVDTIKERLYALLATDYKSQVKSLLGQSYSSKMRIFKNHKVSDHHAIIPTEVRPDMQSLSNRESKIYMMVAERFLESLMAPHEYEAVRVNVTVGQHIFAFNEKVTRQLGYKALKMNNDNVVKKVAFQKGEKYHLQSLKVNEHETTPPDYFNEGSLLKAMENPQNYIQLKEKKHANTLRQTGGIGTVATRADIIEKLFNLNAIESRDGKIKVTSKGKQILDLAPQELTSPLLTAEWEEKLLLIEKGRYNSRHFIDEMKAFTQSIVNTIKNSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPTCKTKKNVQRKTNARCPNCKKKMTLFGRGKDAVYRCVCGHTETQEQMDKRFKNKSSGKVSKKEMKKYMNNEDSLENNPFKDALKNLKL
(297) DNA topoisomerase 3 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305]
2
MKSLIIAEKPSVGRDIANTLNINEKRNGYFENNKYIVTWALGHLVTNATPEQYDASYKEWKLNDLPIIPNKMKTIVISKTRKQFSTVQSLINNNKVKDIIIATDAGREGELVARLILDKAHNKKPTKRLWISSVTNKAIKEGFNKLQDGRKFNNLYHAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVQMRQNEINHFKPQTYYTMKLNAAGLTFHCTKPQSHPDKTVLESIKKAIDGQSGHIASISKTHKKAYPQQLYNLTDLQQDAYKRFHLGPKETLNTLQTLYERHKLVTYPRTDSNYLTDDMVDTLKDRLKAIMATSLKDMAKAQMSQTFSSKQRFVNNNKVSDHHAIIPTEVRPDINQLSQRESKIYMMIAQRYLENLMPPHEYEAIAIELKVGQHTFTFKDKVTTKLGFKAIYENKESINTQIDQLQKGTKLNVTKILIEEHETTAPPYFNEGSLLKAMESPQKFFDLSDKKHDKTLKDTGGIGTVATRADIIEKLFNMNAIEARDGKIKVTSKGKQILELAPQKLTSPLLTAEWEEKLLLIEQGKYNASQFISEMKAFTNQVVNEIKESEQNYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPQCKTKKNVQRKTNARCPNCHKKMTLFGRGKDAVYRCVCGHTETQAQMDKRHKNKKSDKVNKKDLKKYMNNDEGIENNPFQDALKGLKF
(1400) DNA topoisomerase 1 [Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305]
1
MAENLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDAENDYEPKYITIRGKGPVVKELKKHAKKAKKVFLASDPDREGEAIAWHLANILNLEDSTENRVVFNEITKDAVKDSFKHPRGIEMELVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWKIEGEFRYKKTKFTAKFLHFKNKPFKLTEKADVEKITTQLDGDQFEVTKVTKKEKTRYPANPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKKQGTVGLITYMRTDSTRISDQAQSEAKNYIQETYGNDYTSNRKSKGQGDQDAHEAIRPSSTLRTPNEMKNFLTRDQHRLYKLIWERFVASQMAPAILDTVAMDLTQNDIKFRANGQTIKFKGFMTLYVETKDDSEDGKDNKLPNIGEGEMVTATNIEPSQHFTQPPPRYTEARLVKTMEELKIGRPSTYAPTIDTIQKRNYVKNESKRFVPTELGEIVHEQVKDYFPEIIDVDFTVNMETLLDKVADGEIGWKKVISDFYSSFKQDVERAEEEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPKCKEGDVVERKSKKNRIFYGCSKYPECDFVTWDKPIGRDCPKCEHYLVEKKQGRKSQVVCSNCDYKEEEQK
(901) DNA topoisomerase 1 [Paenibacillus terrae HPL-003]
1
MADSLVIVESPSKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFNPKYITIRGKGSILKELKDARKKVKKVYLAADPDREGEAIAWHLAHALDLDDTADCRVVFNEITKQAVKDAFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIILDRENEINEFVPEEYWTITAKLAIKDSTFEAKFHQLRGEKKELSSEADVQEVLEAIGKSSYKVRDVKEKERLRNPSPPFTTSSLQQEAARKLNFRASKTMSVAQQLYEGVDLGKEGTVGLITYMRTDSTRIAVSAQEEAKEFIIQKYGEAFVPESPRQYSKKAANAQDAHEAIRPTSALRDPETVKPFMSRDQFRLYKLVWERFMASQMASAIMDTLSVDIEAGETIFRAAGSKVRFPGFMKVYVEGNDDGKTEEDKLLPPLKSGDKLKKESVEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLETIQKRGYVAIEEKKFFPTELGELVIEQMEEFFPEILNVEFTANMEGDLDHVEEGEGDWVKVLSDFYESFEKRLEVAEEEMKEIEIKDEESDVICDKCGSPMVYKLGRFGKFLACSAFPDCRNTKPIVKDIGINCPTCGEGHVVERRSKKGRIFYGCDRYPECDFVSWDKPSIKPCPSCGGLMVEKRTKQGTKLNCTVCDHSEMLEDSDEGVETS
(29) DNA topoisomerase [Paenibacillus terrae HPL-003]
7
MKTLIIAEKPDMGRTIAAVMEPRAKNNRTYLEGEKYIVTWAIGHLLGLAEPDAYDAKYKRWNIKDLPIIPEQFKIVPNPKTKDQLKIIGELAKRCNAIVNACDAGREGQYIFALIQQQLKLRQPVKRLWISDLTAESIAAGFERLRDASEFEFLTQAARARSEADWLIGMNASRAFTTRHNALLSVGRVQTPVLALIHDREKEIEAFQSQTFYDVWAEFKQDQTKYKGAWQGDRLTKPEEAEAIAAAVRGKTGEITKYDTKQTKEYPFKLYDLTLLQREANAKYSYSAKKTLDVAQALYERHKVISYPRTNSNYVTEQNIDGMHKALRMLGTGPYADLVQQANPNLVHKQNKAVCNPSRVEDHHAILPTLKRPGTLSKEEQNVYDLIIRRFLSHFFPPAEYKMHTVMTQVDKHLFKTSIKELLSLGWKVVLSKADQDKGKKSKAPKKEEEEETDEWTDKKFEIDAGRLVDCIRAEMKEKATQPPKSYTEGTLLKAMESAGKQMENEELREVMKDAGLGTPATRAATIERLKKVGYIEMKGKKILITDKGKMAIDLIRNAGVDLLASPEMTGQWERRLHQISKGEAAQEKFMDNVKKFTLSIIDKVRQQPPAPANAFGEEARGKRSAGKENARSAGASVRTAAKGTRVPSGRGSSAGSATLERTAGAAGSAAGASPSRREALGSCPRSNCSGSIIEGRKGYGCSHYKQGCGFVVWKEYAGKQITETMLKSLLTKGQTQLLSFKRKDGSTVKARIVLNEPGTGQLSVREEN
(571) DNA topoisomerase [Paenibacillus terrae HPL-003]
7
MKVLVLAEKPSVAREIARVMGSREKHKSYIEGPKYVVTWALGHLVGLAEPEDYDSKYTTWNLEDLPILPKSTKLKVLRESNHQFKAVQQLMKRQDIGELIVATDAAREGELLARWIIQMANWKKPFRRLWISSQTDKAIKEGFAKLLPGQQFDRLYESARCRAEADWMIGLNVTRALTCRYNAQLSAGRVQTPTLGMIMEREKEITQFRSQEYDTLTADFGDFQATWRAENGDSRMFDRTQAEALRRKLEGVKGTVDSVKKSEKNEPHPLAYDLTELQRDANQRYGFSAKQTSNVLQRLYEQHKLVTYPRTDSRYLTSDMVDTLKERLNSVAVGPYASLARPLLRKSLTISKRIVDDSKVTDHHAIIPTEQTLLLNQLSPEERKLYDLIARRFISLFYPPARYDAVAVAVTVEQETFQVKGTTIKDSGWRAVYDGSLYDTDEEAEEREDNGSGVILPELKKGDSVRIQRCLVRAGRTMPPKRYTEAALLAQMEKHGLGTPATRADLIEKLVSSDTIERQGNVMHPTGKGKQLIELAAPQLRTPELTARWEAELERIARGQGQPGPFLDSIRAMAKELVSTVKNSSAEYKPHNVTNSHCPDCGTKLLEKKGKQGKFLVCPSADCGYRRSGEKRLSNRRCPQCHKKMEMKEGKAGLYVRCLACGITETLDKDKQRVNKREQQKLVRQYEKQEPLGSSLGDLLKAAMDQKQGK
(1172) DNA topoisomerase [Bacillus coagulans 36D1]
2
MKSLVLAEKPSVGRELARVLGCTENKKRYIEGPRYIVTWALGHLIELKMPEDYHPKYKEWRMEDLPILPDKMEIKTIRQTYPQYKAIEQLGKRSDIKDCIIATDAGREGELVARWILEKMHWRKPVKRLWISSQTDKAIKDGFKQLKPAKQYDNLYHSAVCRSEADWLIGLNVSRALTVKYNDPLSAGRVQTPTLAMVLEREREIQSFVPKKYWTIEALAGKLEVSYDHHGEKRIFDEQKANAIHAALSGQTAVVTEVIRKQKQEQQPLPYDLTELQRDANHRFGFTAKKTLNVLQNLYEQHKLVTYPRTDSKYLTKDMENMMYDRLLAVKDAYKEEVQPILSRKGKILAKRVINDAKVTDHHAIIPTDERPALSDLSADERKIYDLIVKRFLALFYPVYEYETVQFKLQAGGKTMTGRTMAVKNAGFTAVLHHEQERENTALLSIKEGKKFKLEQIRLSQHLTEAPKRYSEADILSRMEKYGLGTPATRADIIERLVSSETISRESGRLVPTPKGKQLIDLVNDELKSPELTAKWEEQLEAIARGKGNPKQFLETIRRETVRLVREIRTSDKKYRAHNLTGTKCPECGSLMKEVNGKDGKKLVCSNRECRFTKRKSPKLSNRRCPTCHKKMEIHHGKSGVYFQCRHCNIVQKADEKKKTLSKHEEKKLLQKYTKKEESFGNSLADALKAALEKE
(1637) DNA topoisomerase 1 [Bacillus coagulans 36D1]
1
MDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIDRENEIKSFVPEEYWTIAGSFKKGKDTFQASFYGVDGKKIQLKSEADVKKITGMLKSDKFQVSSVTHKEKKRNPAPPFTTSSLQQEAARKLNFRAKKTMMVAQQLYEGIDLGKEGTVGLITYMRTDSTRISEVAKTEANQYIREKFGENYLRQEERKEKKQANAQDAHEGIRPTSIFRDPGSVKSFLSRDQYKLYKLIWERFMASQMAPAILDTMSATLANGTVLFRASGSKIQFPGFMKVYVEGSDDQQEEGERYLPHLEEGDVVQSESIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALENKRFVPTELGEIVLELIREFFPEIIDVEFTADMEKDLDEIEEGKVPWVQIIDAFYQNFEARLKKAETEMEKIEIKDEETGEMCELCGSPMVYKMGRYGKFMACSNFPDCRNTKPIVKKIGVTCPKCGKGEIIERKTKKNRIFYGCDRYPECDFVSWDKPVGRKCPKCGDMLVEKKLKKGTQIQCVHCDYKEQSVK
(1856) DNA topoisomerase [Bacillus coagulans 36D1]
7
MSFPLIIAEKPDQGRTLCSVFPHVKREGYIEIRPNEIFPEGAFCTWAIGHLTQLVPPEHYNPAWEQWKLETLPILPETFKYEVAKSKYKQFQIVKKLVKDARVTNIIHAGDAGREGELIIRNILHLCGAKKPLRRLWISSLTPQSIREGFRHLLHDEDTRPLYDEAYARACADWLVGMNASRVYSLLLRQKGMRDVFSVGRVQTPTLALIVKRELEIEHFKPEPFWEVTAMFQFDDKQYEGKWVKDGESRLNDPAMAARIAAFCRQKPAEVAELKKEKKEFQPPLLFNLSSLQAAANRAFQFPPKKTLDLVQSLYQKGIVSYPRSDSQYVTKGEAETFPGILEKLSACPEYAPYFPLPKRSILQNKRYVNEKKVSDHYAIIPTEQVVAPGSLPDGEKKIYDMIVRRLIAAHYGNAVFHYTTVKTVVDSRATFLSKGTQMEAEGWRKVIFSKEKEKDGILPDVKQGEKGVVIDTNVKEGKTQPPKRYTEGQLITLMKTAGKYIEDRELEKVMAEVEGLGTEATRAGVITILKDRKYIEVKKNQVYATDKAKVLIRAIGGKILASPEMTAKWEKRLREIGKGAAEAAAFMEQTKKLSRKIVQDAVQAAAEWDFSGLKTDDIKRPESKYTIGKKAGKCPACGGDIVDKGDFYGCSAYRKSGCTFTLSKSILGKKISLANVRKLLAGEETNMIKGFRKNGKTFDAKLKWEDGKLRFIFAKQQTGR
(1602) DNA topoisomerase [Paenibacillus mucilaginosus KNP414]
7
MKTLIIAEKPDMGRNIAAAIDPKAKNQRTYIEGEQYIITWAIGHLIGLAEPDAYDDRYKKWNLGDLPIIPEQFKLVPNAKTKDQLKVIAELAKRCSHLVNACDAGREGQHIFSLIQRHLKLKQPVKRLWISDLTPETIRRGFAELKEGADFEPLTRAAKARSEADWLIGMNGSRAFTTKHKELLSVGRVQTPVLALLYDRQKEIEAFQSNKYYEVEAWFEQGETLYRGLWQGERLTDGEKAKALAEKVKGKRGRVESYEVKDTKEYPFKLYDLTLLQREANAKFGFSAKKTLDLAQTLYEKHKAISYPRTNSNYVTEQNIPEMHRALDQLAKTDYRGLVEGADKKFVHKNNKAVCNPSKVEDHHAILPTHKTPGALPPDEAKLYDLIVRRFLSQFYPAASYKMHTVLTAAEGERFKSTIKQLLDLGWKVIYADQKKEKPTGRGKGKADGKEDDEESAEEEVQTPFTLDAAQEVRCKKSSAKEKETQPPKPYTEGTLLKAMESAGKQIEDEELRDAMKDSGLGTPATRASVIERLKNVGYVVMQGKRIAITPKGRTAVELIRGAGVELLTSPEMTGHWERRLNEIARGTASDEQFMANVKKFATMIVDKVRVQRPAEKTAFEGEAAAAGGAGRGRAAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRARACASLPAPAPALRSPRPRLRFAPRASHQLGRPSLTLPLHAPACRCLSAASGVRGSCASSGT
(482) DNA topoisomerase [Paenibacillus mucilaginosus KNP414]
2
MTNELQDVNNAKEAGTIHFCPERSTIRMKSLVLAEKPSVAKEIARVLGCQQKHKHYMEGPQYVVTWALGHLVTLAEPEEYDPKYKTWNLEDLPLLPSKMKLKVIRETTPQFKAISQLAQRGDLKELIIATDAGREGELVARWIMELVRWRKPYKRLWISSQTDKAIRDGFAQLKPGPAYDPLYRSAVCRAEADWLIGLNITRALTCKHNAQLAAGRVQTPTLAAMMDREAQIRSFQAKDFWMLRAQLGSFQALWRSQAHPDGRLFDKAAADTLLERLKTARSAKVSALKVSEKSEPHPLAYDLTELQRDANKRLGFTAKQTSNVLQRLYEQHKLVTYPRTDSRYLSSDMVSTLPDRLKALLGTPYGASAKGLLARPLPVTKRIVDDSKVSDHHAIIPTDERPQLQLLGADERRLYDLIVRRFLSLFFPAFRYDETAVTLDIAGESFHAKGRIVKDQGWKAVYDGSSAPSEADDDDAPEEEPSSLQSLPALQLGTELKDLRLSQQKGTTKPPGRYTEAGLLSVMEKQGLGTPATRADIIEKLLSTDTIERRMNTLQPTGKGVQLMELVVPELRSSELTASWERELERIAKGQGDPDAFMAGIRKQTEAIVRDVKNSSAEYKPHNLTHSKCPDCGSPLQDIKGKRGRMLVCSSRECNYKRAAEAQLSNKRCPQCRKKMEIHTGKAGKYAQCRPCNVIEMLNDTGGAGGRGKAGKRQQSQLAEQYSDNAKLPSALEE
(1186) DNA topoisomerase 1 [Paenibacillus mucilaginosus KNP414]
1
MADSLVIVESPAKAKTISKYLGSKYIVKASMGHIRDLPKSQIGVEVKKNFEPKYITIRGKGSVLKELKDASKRVKKVYLAADPDREGEAIAWHLAHYLELSDQDACRVVFNEITKQAVKDAFKTPRKINQDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKLIYDRENEIKAFEPEEYWTITAKLAANKSDFEAKFYSVNGEKKELKSQSEVNEVLALLGGSDFVVSEVKEKERLRNPSPPFITSSLQQEAARKLNFRAAKTMSVAQQLYEGIDLGSEGTVGLITYMRTDSTRISPVAQEEAKEYITGKYGEAYYPAEPRNYVKKNANAQDAHEAIRPSSVLREPESIKAHLSRDQFRLYKLVWERFVASQMASAVLDTMTVDLNAGPVVFRAVGSKIKFHGFMKVYVESSDEGAADAADDDKFLPPLKQGDEAKPQAIDPKQHFTQPPPRYTEARLVKALEEMGIGRPSTYAPTLETIQKRGYVAIEEKKFVPTELGELVIQQMIEFFPEILDVEFTAHMEEGLDHIEEGKEDWVRVLSEFYDSFEKRLEVAEEEMEKIEIQDEVSDEICEKCGNHFVYKMGRFGKFLACSGFPDCRNTKPIVKDTGVTCPSCHEGKIIERRSKKGRIFYGCDRYPACEFVSWDKPVEQPCPKCGALLVEKRNKSGTFIQCVSCDFKEEAKEDDRED
(754) DNA topoisomerase 3 [Staphylococcus lugdunensis HKU09-01]
2
MKGLIMKSLILAEKPSVARDIADALHITHKKNGYIENEKYIVTWALGHLVTNAQPEHYDKRYQTWNLNDLPIIPKHMKTIVIGKTSKQFKTVKSLLLNKQVNNVIIATDAGREGELVARLILDKVGNKKPIQRLWISSVTKKAIQQGFKNLQDGRKYNHLYQAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVYERQKEIKQFKPEDYYTLHIKVAGYEFDLDSQQRFKQREDLEHIVKAIAQNNIQVTTVETKRKKSYPQALFNLTDLQQEAYRRFKMGPKETLNTLQNLYERHKLVTYPRTDSNFLTSDMVETFSERLQALLATDYKVAVKNLMKKSFNTKLNIINDKKVSDHHAIIPTEIRPDLNQLTAREQKIYMLVAERFIASLMEPYQYEMTTVKLEVAQHQFKMKENIPLQLGYKALFDTTQTEVKKQPFRQGQQYPISQTNIKKHQTTPPDYFNEGTLLKAMESPQQVIHIQDKKYAQMLKQTGGIGTVATRADIIEKLFNINAIESTDGKIKVTSKGQQILDLAPEALTSPLLTAEWEEKLTRIEKGKYNQRKFIQEMQDFTTKIVHDIKNSVQTYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPSCKTKKNVQRKTNARCPNCKKKMTLFGKGKEATYRCICGYTETQRHMDERMKHKNNNKISKKEMKKYMSSDEKLENNPFKDALKNLKL
(1321) DNA topoisomerase 1 [Staphylococcus lugdunensis HKU09-01]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDVDDNFEPKYITIRGKGPVVKELKKHAKKAKKVFLASDPDREGEAIAWHLSNILELEDSKENRVVFNEITKDAVKESFKHPRDIEMDLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYQKSKFTAKFLHYKNKPFKLQNKDDVNKITAKLDGDQFEITNVNKKEKTRNPAQPFTTSTLQQEAARKLNFKARKTMMIAQQLYEGIDLKRQGTVGLITYMRTDSTRISDAAKNEAKSYITENYGSNYVSKRQAKGKQGDQDAHEAIRPTSAMRTPNEMKSYLSRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNDIKFRANGQTIKFKGFMTLYVEAKDDKENDKENKLPNLKEGDKVTATQIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLDSKRFVPTELGEIVYEQVKEYFPEIIDVEFTVNMETLLDKIAEGDMKWRKVIDDFYNSFKLDVARAEKEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPTCKKGDVVERKSKKNRIFYGCSNYPECDFISWDKPIGRDCPKCEHYLVEKKKGRSSQVVCSNCDYQEEAQK
(511) DNA topoisomerase 1 [Macrococcus caseolyticus JCSC5402]
1
MAENLVIVESPAKAKTIEKYLGKKFKVVASMGHVRDLPRSQMGVDTENDFEPRYITIRGKGPIVQDLKKHAKRAKHVYLASDPDREGEAIAWHLAHILNIDEKAASRVVFNEITKDAVKESFKHPRQIEQNLVDAQQARRVLDRLVGYNISPVLWKKVKKGLSAGRVQSVALKLIIDREEEINAFKPEEYWTIDGLFEYDRKQFKAKFLHENNKPKKLKQEDDVKAIVKQLKSDAFEVTDVTKKEKLRNPAQPFTTSSLQQEAARKLNFKARKTMMLAQQLYEGIDLKKQGAVGLITYMRTDSTRISDTAKNEAASYIEEHYGKAYLSKRSSKSGGAQDAHEAVRPTSVMRTPSEMKAYLSRDQLRLYKLIWERFMASQMAAAVIDTVSVDLVQNNIKFRANGQTIKFKGFMSVYIEGQDEETEDGENKLPVLEVGDTVKAVNIDENQHFTQPPPRYTEARLVKTMEEKGIGRPSTYAPTIDTIQKRNYVKVDQKKFYPTELGIIVNESVKEYFPEIIDVDFTVNMETLLDKIASGDMEWKKVISTFYGDFKTHVERAEAEMEKIEIKDEPAGEDCEKCGSPMVYKMGRYGKFMACSNFPECRNTKAIVKTIGVACPKCKDGEVVERKSKKNRIFYGCSNFPECDYISWDKPIARNCPKCDTQLVERKKGKQTQVVCTNCDYDEKPQ
(1347) DNA topoisomerase 3 [Macrococcus caseolyticus JCSC5402]
2
MKSVVLAEKPSVARDIARVLKCNQKKNGYMENDKYIVTWALGHLVTNADPEQYDAKYKQWDLNMLPIIPERMKTVVIGKTRKQFNTVKAQIERQDVNEIIIATDAGREGELVARLIIEKCKGNKPMKRLWISSVTDKAILDGFKHLKPAQAYQGLYEAAMARSEADWIVGINATRALTTKYDAQLSTGRVQTPTLQMVKIRQDAVQKFQPKTYYSIELVSGSDKFKWQSGSQIFDESKVDGLLKDIQGKQAVVQDVVSKEKKRYPGKLYDLTSLQQDAYKRFKYSAKETLNAMQSLYETHKYVTYPRTDSNYLTTDMESSLKERVASLGATPYKDQVVKLLKTHIKGGSHFINNAKVSDHHAIVPTEIRANLEALGAREKNIYLLIAERFLSNLMEPHIYNEETITVQIGKEIFTLKTETTVKAGFKALYEQSSIERHKVYHKGEVLSSVSLKKTTGETQPPAYLNEGTLLKAMENPASIFNIDKESTTTLKSAGGIGTVATRADIIEKLYNLNAIENNNGNIKVTNKGRQLLELAPDALKSPELTADWEHKLTRIEKNKYGRKQFMREMIDFTKEIIDEIKSSDEKFKHDNLTSTECPTCGKFMLEKKTRNGKMLVCQDPTCGTKKNVQRKTNVRCPECKKKLTLHGKGPKAMYSCVCGFRETQEQMDKRFNSKKTGKVSKKEINKYMKKEEPINNPFADALKNLNL
(1713) DNA topoisomerase [Bacillus cellulosilyticus DSM 2522]
7
MKLIIAEKPDQGAKLAAPFSSKKQAGFIEISPNDTFPKGALVTWAVGHLCELVPPDYYHPHWKKWSLKNLPIIPEQFQHRVITSKWKQFNIIKRLIHDQRITEIIIAGDAGREGEAIIRIVLTLCKNSKPMKRLWISSLTKNAVLTGFNHLLDEAETRSLYYEALSRSCADWIVGINASRAYTLLLQQKGIKDIFSIGRVQTPTLALIVQREKEIETFKQEEFWEVVATFHMNNNQYKGKWHKENDSRLKEKELAEKIRRFCVHKEATIQSIEKKRKDFKPPFLLNLSNLQALANKRFKYSPQKTLDIAQKLYTKGIISYPRSDSNFITKEEAKMLPDILFKLSKLEHFEKYFPLQVESILNNKRYVNDKKVSDHYAIIPTEQVTNPTKLQSEESNIYILIVEQLIAAHYKSAIIDYTTIQTLVDNRATFLTKGKEIVQAGWREVLYKNDDKASNDEDQQLPALREGESGHVFDVDIKSGKTQPPKRFTEGELITVMKTAGKALDDKELVHILKNTEGLGTEATRAGIIQVLKDRKYIQVIKNQVFVTEKGKLLVEAVGDSILASPEMTAKWEKRLSEIGEGKAAPKIFIEQAKNLACNVLETANKQVENWDFKNIDISSIESFSSKNKKGRRQTVVGKCKKCDGQIIDKGSFYGCSNYRNTNCSFTLSKILLGKTITQTQVKKLLTKGKTDIIHGFKKNSKTFNASLILNTTTYKLEFKWDN
(1822) DNA topoisomerase 3 [Bacillus cellulosilyticus DSM 2522]
2
MKKSVVIAEKPSVARDIARVLKCNKKGNGFIEGDKYIITWALGHLVTLADPEAYDQKYKSWKIEDLPMIPNHLKLVVIKKTSKQFHAVKSQLHRSDVGDIIIATDAGREGELVARWIIEKAKISKPTKRLWISSVTDKAIKEGFQQLKNAKAYENLYESAVARSEADWYIGLNATRALTCKYNAQLSSGRVQTPTLAIISQREEEIRSFRPKAFYGITAKTEENLSLSWQDKRSKDFRSFSKDNITNILSNIKGNNATVVEVSKKNKKNFAPQLYDLTELQRDANKAFHYSAKETLSIMQRLYEQHKVLTYPRTDSRYISDDIVDTLKDRVIACGKSYSEYSKLANKIVQKPLQANKSFVDNTKVSDHHAIIPTEEVANIAMFSDKERKIYDLVVKRFLAVLSPPFEYEQTTIVAEIASETFIARGKKVNSLGWKEVYGNVIEDEESDDVKEQVIPQIVKGDTLTITKVSQTEGETKPPARFNEATLLSAMENPAKYIVGETKELAKTLEKTGGLGTVATRADIIEKLFNSFLIEKKEKDIHLTSKGKQLLDLVPSDLKSPALTGEWEQKLEAIAKGNLKKNDFINDMKEYAKTVVHEIKNSDKKFKHNNMTGTKCPECGKNMLEVNSKKGKMHICQDRECGHRKNISKVTNARCPKCKKKLELRGQGEGQVFACKCGHKEKLATFNERKKKEKNTKLSKREVNNFMKKQNKQQDDEPFNPALADALAKLKLK
(1364) DNA topoisomerase 1 [Bacillus cellulosilyticus DSM 2522]
1
MSDYLVIVESPAKAKTIGKYLGKKYAVKASMGHVIDLPKSQMGVDVEEGFTPKYITIRGKGPILKDLKAAAKKAKRVYLAADPDREGEAIAWHLAHSLNIDEKSECRVVFNEITKQAIKDSFKRPRTINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIDREKEINAFEPEEYWSIDAKFEKDGEAFEAKFISKDGEKLSLKSENDVKEVLKALSGESFQIEKVKKRERKRNPVVPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDIGKLGTVGLITYMRTDSTRLSETAKAEAKTYIESHYGKEYVNQQEAKTKQKSNSQDAHEAIRPTSVDLDPKSVKSYLSRDQLRLYKLIWERMVASQMAPAILDTMSVDLVNNGVAFRATGSKLKFAGFMKVYIEGNDDGKKEEDRLLPEMSEGEQAKAEAIDPNQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQRRGYVALEDKRFIPTELGEIVLELIEEFFPEILNVTFTAKMENDLDSIEDGEEEWVKVIDEFYSDFERRLKTAEEEMKEVEIKDEPAGEDCEKCGHEMVYKMGRFGKFMACSNFPDCRNTKAIVKDIGVKCPECKEGNVVERKSKKRRIFYGCDRYPECEFISWDKPIARKCPKCEHMLVEKKTKKGIHVQCSKCDYREDQN
(63) DNA topoisomerase 3 [Bacillus licheniformis DSM 13 = ATCC 14580]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDRYIVTWALGHLVTLADPEGYGKEYQSWRLEDLPIIPEPLKLVVIKKTGKQFQAVKSQLIRKDVKDIVIATDAGREGELVARWIIEKAKVTKPLKRLWISSVTDKAIKDGFKNLKNGKDFENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREEDIKNFKPVPYFGLRAAVDGMTLTWQDKKTSQTRTFNASVTSQLAGALQGKPAVIVDLKKTAKKSFAPGLYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSNDIVPTLKDRLEGMQVKPYAQHVARILKRGVKANKSFVNDAKVSDHHAIIPTEEPLALGALSEKERKLYDLIAKRFLAVLMPPFEYEETKVFAEIGGETFTAKGKTVQSQGWKAVYDFADEDDDEEEKDQTLPKLAKGDTLSVRSLTETKGETKPPARFNEGTLLSAMENPAAFMQGEEKNLVKTLGETGGLGTVATRADIIEKLFNTFLIEKKGKDIYITSKGKQLLELVPSDLKSPALTAEWEQKLSGIAKGKLKSSAFIKEMKEYAKQTIREIKSSNQKFKHDNITGTHCPDCGKLMLKVNGKRGTMLVCQDRECGHRKTVAKQTNARCPVCHKRMELRGHGEGQTFACVCGHREKLSVFEKRRAKDKNSKASKRDVHSYMKKQNKDEPINNALAEQLKKLKLDQ
(1156) DNA topoisomerase 1 [Bacillus licheniformis DSM 13 = ATCC 14580]
1
MSEYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFIPEEYWTIEGSFLKGKETFEASFFGINGEKHQLKSEDDVKQILSRIKGNKFEVKKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAQEEAASFIGEQYGKEFLGSKRKPAKKNENAQDAHEAIRPTSVLRKPSDLKAVLGRDQLRLYKLIWERFVASQMAPATLDTMSVDLENNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKNKMLPDLAEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFIPTELGEIVLDLIMEFFPEIINVEFTAKMEKELDDVEDGNIQWVQIIDSFYKDFEKRVEKAEAEMQEVEIEPEYAGVDCEACGHPMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPSCKTGNIVERKSKKRRIFYGCDRYPECEFVSWDKPLERKCPKCEDMLVEKKLKKGVQVQCVNCDYKEEQQK
(1157) DNA topoisomerase 1 [Bacillus licheniformis DSM 13 = ATCC 14580]
1
MSEYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFIPEEYWTIEGSFLKGKETFEASFFGINGEKHQLKSEDDVKQILSRIKGNKFEVKKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAQEEAASFIGEQYGKEFLGSKRKPAKKNENAQDAHEAIRPTSVLRKPSDLKAVLGRDQLRLYKLIWERFVASQMAPATLDTMSVDLENNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKNKMLPDLAEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFIPTELGEIVLDLIMEFFPEIINVEFTAKMEKELDDVEDGNIQWVQIIDSFYKDFEKRVEKAEAEMQEVEIEPEYAGVDCEACGHPMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPSCKTGNIVERKSKKRRIFYGCDRYPECEFVSWDKPLERKCPKCEDMLVEKKLKKGVQVQCVNCDYKEEQQK
(62) DNA topoisomerase 3 [Bacillus licheniformis DSM 13 = ATCC 14580]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDRYIVTWALGHLVTLADPEGYGKEYQSWRLEDLPIIPEPLKLVVIKKTGKQFQAVKSQLIRKDVKDIVIATDAGREGELVARWIIEKAKVTKPLKRLWISSVTDKAIKDGFKNLKNGKDFENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREEDIKNFKPVPYFGLRAAVDGMTLTWQDKKTSQTRTFNASVTSQLAGALQGKPAVIVDLKKTAKKSFAPGLYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSNDIVPTLKDRLEGMQVKPYAQHVARILKRGVKANKSFVNDAKVSDHHAIIPTEEPLALGALSEKERKLYDLIAKRFLAVLMPPFEYEETKVFAEIGGETFTAKGKTVQSQGWKAVYDFADEDDDEEEKDQTLPKLAKGDTLSVRSLTETKGETKPPARFNEGTLLSAMENPAAFMQGEEKNLVKTLGETGGLGTVATRADIIEKLFNTFLIEKKGKDIYITSKGKQLLELVPSDLKSPALTAEWEQKLSGIAKGKLKSSAFIKEMKEYAKQTIREIKSSNQKFKHDNITGTHCPDCGKLMLKVNGKRGTMLVCQDRECGHRKTVAKQTNARCPVCHKRMELRGHGEGQTFACVCGHREKLSVFEKRRAKDKNSKASKRDVHSYMKKQNKDEPINNALAEQLKKLKLDQ
(1429) DNA topoisomerase 3 [Bacillus subtilis subsp. spizizenii TU-B-10]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGHLVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVIATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKDLEGKQAVIAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMADEDDEQEDDRDQTLPALQKGDALTVRMLTETNGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKDKDIFITSKGKQLLQLVPEDLKSPALTAEWEQKLSAIAAGKLKSSVFIKDMKAYANQTVKEIKNSSQTFRHDNVTGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKKMELRGQGEGQTFACVCGHREKLSVFEKRKNKDKGRASKRDVSSYMKKQNNKEEPINNALAEQLKKLGLDK
(791) DNA topoisomerase 1 [Bacillus subtilis subsp. spizizenii TU-B-10]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPLKSEADVKDILSQLKGNKYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQAYGKEFLGGKRKPAKKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMSVDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVGLDNKRFVPTELGQIVLELIMEFFPEIINVEFTAKMEKDLDNVEEGNIEWVQIIDNFYTDFEKRVKKAESEMKEVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGEGNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVECDYKEEPQK
(1664) DNA topoisomerase 1 [Brevibacillus brevis NBRC 100599]
1
MADTLVIVESPTKAKTIGKYLGSKYIVKASIGHVRDLPKSQMGVDVTHNFEPKYITIRGKGDVLKGLKDAAKKVKKVYLAADPDREGEAIAWHLAQYLGLDMNQPLRVVFNEITKDAIKEAFKHPRHINMDLVNAQQARRILDRLVGYNISPILWKKVRKGLSAGRVQSVAVKLIMDREREIQEFIPEEYWTIASTLISDGKEINAKFYGYGDEKVELHSEDDVAAVLKRMKNKPYVVQKVTKRERKRNPAPPFITSSLQQEAARKLNFRTSKTMRIAQELYEGIDVGNKEGAVGLITYMRTDSTRLSVTAQNEAKEYILEKYGPDYVLSEPRNQAKNENAQDAHEAIRPTGVMRTPDEIKEYLSRDQLRLYRLIWERFLASQMSSAVLDTMSVDIDAGGVTFRATGSKVKFPGFMKVYIEGNDDGTEEESFLPPIEEGQILDQKEIEPSQHFTQPPPRFSEARMLKSMEEMGIGRPSTYAPTLETIQKRGYVALEEKRFVPTELGEIVITLVEEFFPEILNVEFTAHMESGLDNIEAGNTNWVQVLDDFYQDFAKRVVVAEEEMKEVELKVEESDETCELCGSVMVYKLGRFGKFLACSGFPDCRNTKPIVKEIGVKCPQCETGEIIERKSKKSRIFYGCNQYPECDFVSWDKPIARPCPKCSSMLVEKKRKKQGVSIICTKCDYQEEADS
(1622) DNA topoisomerase 3 [Brevibacillus brevis NBRC 100599]
2
MSKTVVLAEKPSVGRDIAKVLQCHKKGNGFFEGDKYIVTWALGHLVTLADPEAYGQQFGSWRIEDLPIMPSPLRLVVIKESNRQFQVVKQQLRRNDVGQIVIATDAGREGELVARWILELVHVNKPIKRLWISSVTDKAIREGFRNLKDGKNYENLFASAAARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAIVATREEEIRRFTPKPFYGLSAVAQGPIQLQWQDQQTKDFKTFSKEKADQLIAALKQEKNAEVIEITRAHKKTYAPQLYDLTELQRDANRMFGYSPKQTLSIMQGLYEHHKAVTYPRTDSRYLSADIVETLPDRIKAVQMKPYAPLAARILRAPIKANKSFVDDSKVSDHHAIIPTEQAVFLGDLSDKERKIFDLIVKRFLAVLLPAFEYEQTTIQAKIGNETFLAKGKTVLSQGWREAYDHDVEEDDAKDGVKEQILPSLAKGDRLQIQSISQTKGETKPPEPFTEASLLSAMENPAKYMANESKDLIKTIGETGGLGTVATRADVIEKLFNSFLLEKRGKHIFVTAKAKQLLELVPDEMQSPTLTAQWEQKLGAIAKGSLNKRAFIEEMKTYAKEVVQQIKNSDQTFRHDNLTRSRCPECNKFLLEVNGKRGKMQVCQDRECGYRKSIAKQTNARCPKCHKRLELRGEGEGQTFVCGCGHKEKLKTFQERRDKEKGSKVSKKEVSKYLKGQDKEPDEGINSALKDALSKLKFD
(166) DNA topoisomerase [Brevibacillus brevis NBRC 100599]
7
MKILIIAEKPDMGRNIAAAIDPKAKNHRTYLEGEKYMITWAIGHLIELAEPEAYDQKYKKWNINDLPIIPEPFKLVPNRKTIDQLKIIGQLAKRSNLLVNACDAGREGQHIFSLIQRHLKLTQPVKRLWISDLTPETIRKGFAEMKDAAAYENLTRAAKARSEADWLIGMNGSRAFTTKHNVLLSVGRVQTPVLALIYDRQKQIEAFSSVTFFQVEGHFSQGERMYKGLWQGDRLTDPAKAEMLARKVKGKQGRIASYEVKDTKEYPFKLYDLTLLQREANGKYGFSAKKTLDIAQALYEKHKVISYPRTNSNYVTEQNIPEMHNTLSSLQGTGYDALVKGANRSLVHKGNKFICNPAKVDDHHAILPTNRKASGLTPDEQKLYDLIVRRFLSQFYPPAEYKMHTVITDVENEFFRTSVKEQKSLGWKIIYADQQKEKPKNGKGTAKEEEDKEEIEVNEPFIIQSDASVVCSDAMVKEKETQPPKHFTEGTLLKAMESAGKQIEDEELRDAMKESGLGTPATRAATIERLKKVGYVEMQGKKVQLTLKGRTVIELIRGAGIELLTSPEMTGHWERRLNEISRGTAADGQFMENVKKFATMIVEKVRVQSRAEKTLFESESTTQKGSSKTRGRAGGRSTGKSGGSTATTRASTRSAAKTATTTSSIITKCPRPGCGGSIFMGRKGYGCSNYNVGCKFVIWKENYGRMLTDTQIKALIEKGKTGKMKLERQDGTPFQAKLILKSVESGELTFEQ
(1875) DNA topoisomerase [Paenibacillus polymyxa M1]
7
MKVLVLAEKPSVAREIARVMGSREKHKSYIEGPKYVVTWALGHLVGLAEPEDYDSKYATWNLEDLPILPKNSKLKVLRESNHQFKAVQQLMKRQDIGELIVATDAAREGELLARWIIQMANWKKPFRRLWISSQTDKAIKAGFAKLLPGQQFDRLYESARCRAEADWMIGLNVTRALTVRYNAQLSAGRVQTPTLGMIMEREKEITQFRSQEYDTLTADFGHFQATWRAENGDSRMFDRTQAETLRHRLEGAKGTVVSVKKSEKNEPHPLAYDLTELQRDANQRYGFSAKQTSNVLQRLYEQHKLVTYPRTDSRYLTSDMVDSLKERLSSVAVGPYASLARPLLRNKLPITKRVVDDSKVTDHHAIIPTEQTLLLNQLSPEERKLYDLIARRFISLFYPPARYDAVAVSVMVGQETFQVKGTTIKDSGWRAVYDESHYELDDEEIDDRENNGRGVILPELKKGDSVQLQRCIVRAGRTMPPKRYTEAALLAQMEKHGLGTPATRADLIEKLVSSDTIERQGNVMHPTGKGKQLIELAAPQLRTPELTARWEAELERIARGQGQPEPFLNSIRAMAKELVSTVKNSSAEYKPHNVTNSHCPDCGTKLLEKKGKKGKFLVCPSADCGYRRSGEKRLSNRRCPQCHKKMEMKEGKAGLYVRCLPCGITETLDKDKQRVNKREQQKLVKQFEKKDSFGSSLGDLLKAAMEQKQGE
(1285) DNA topoisomerase [Paenibacillus polymyxa M1]
7
MECMKTLIIAEKPDMGRTIAAVMEPRAKNNRTYLEGEKYIVTWAIGHLLGLAEPDAYDAKYKRWNIQDLPIIPEQFKIVPNPKTKDQLKMIGELAKRCNAIVNACDAGREGQYIFALIQQQLKLRQPVKRLWISDLTAESIATGFERLRDASEFEFLTQAARARSEADWLIGMNASRAFTTRHNTLLSVGRVQTPVLALIHDREKEIEAFQSQTFYDVWAEFKQDQIKYKGAWQGDRLTKPEEAEGIAAAVRGKEGKITKYDTKQTKEYPFKLYDLTLLQREANAKYGYSAKKTLDVAQALYERHKVISYPRTNSNYVTEQNIDGMHKALRMLGTGPYADLVQQANPNLVHKQNKSVCNPSRVEDHHAILPTLKRPGTLSKEEQNVYDLVIRRFLSHFFPPAEYKMHTVMTQVDKHLFKTNIKELLSLGWKVVLSKADQDKGKKSKTSKKEDEEETDEWTDKKFEIDAGRPVDCVRAEMKEKATQPPKSYTEGTLLKAMESAGKQMENEELREVMKDAGLGTPATRAATIERLKKVGYIEMKGKKILITDKGKMAIDLIRHAGVDLLASPEMTGQWERRLHQISKGEAAQEKFMDNVKRFTLSIIDKVRQQPPAPAHAFGEEARSNRSGGKGNARSVGASGRATAKGMDRTPSGGGSSAGSAALKQAAPPTRRSSATKAVRSSSDGQSDASVSQRQALGSCPCSNCGGSIIEGRKGYGCSHFKQGCGFVIWKEYAGKQITETMLKSLLAKGQTQLLSFKRKDGSTVKARIVLDVPGTGQLSVREES
(247) DNA topoisomerase 1 [Paenibacillus polymyxa M1]
1
MADSLVIVESPSKAKTIGKYLGSKYIVKASMGHIRDLPKSQIGVEVENDFNPKYITIRGKGSILKELKDARKKVKKVYLAADPDREGEAIAWHLAHALELDDTADCRVVFNEITKQAVKDAFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKIILDRENEINEFVPEEYWTITAKLAIKDSTFEAKFHKLHGEKKELSSEADVQEVLEAIGKSSYKVRDVKEKERLRNPSPPFTTSSLQQEAARKLNFRASKTMSVAQQLYEGVDLGKEGTVGLITYMRTDSTRIATSAQEEAKEVIVQKYGEDFVPESPRQYSKKSANAQDAHEAIRPTSALRDPETVKPFMSRDQFRLYKLIWERFMASQMASAIMDTLSVDIEAGEAIFRAAGSKVRFPGFMKVYVEGNDDGKTEEDKLLPPLQPGDKLKKESVEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLETIQKRGYVAIEEKKFFPTELGELVIEQMEEFFPEILNVEFTANMEGDLDHVEEGEGDWVKVLSDFYESFEKRLEVAEEEMKEIEIKDEVSDVICDKCGSPMVYKLGRFGKFLACSAFPDCRNTKPIVKDIGMNCPTCGEGHVVERRSKKGRVFYGCDRYPECDFVSWDKPSIKPCPSCSGLMVEKRTKQGTKLNCTVCDHSEMLEESDESVETS
(598) DNA topoisomerase [Paenibacillus sp. JDR-2]
2
MKSLVLAEKPSVAKEIARVLGCSSKNKSYMEGPDYVVTWALGHLVTLAEPEDYDPKYKTWNLEDLPLLPGKMNLKVMRETSHQYKAVAQLCKRPDIGELIIATDAGREGELVARWIMELVHWRKPFKRLWISSQTDKAIKDGFKALKPGQQYNNLYASAVCRAEADWLIGLNVTRALTVKYNAQLAAGRVQTPTLGALIDREKEINQFQSQPYWTVSAELGAFQALWRQNDNHDGRVWDRSEAEAVIARLQGKSAKVDKLRTTQKSEPHPQAFDLTELQREANKRLGFSAKMTSNVLQKLYEQHKLVTYPRTDSRYLSSDIVPTLKGRLESVAVGPYAPLARKLLRGQLTVTKRFVDDSKVSDHHAIIPTDEYVNLSALSNDERKLYDLIVRRFIALFYPPYTYDETSVVLTVGQDKLYAKGKVQKDIGWKELYGGSDARFTADEDDEEENGRGEDKSTPEQLLPELVQGQAVQVKQSRLKELRTLPPARYTEASLLSKMEKHGLGTPATRADIIEKLLSTDTIERTQNRLVPTSKGKQLIELVVDELRSPELTAKWERELELIAHGQGDAKRFMAGIREQANKWVTAVKNETKEYKPHNLTHSRCPECGKLLMEVKGKRGKSLVCSDRECSYRRQAEPALSNKRCPQCHKKMEIHNGKAGKYAQCRPCNVIEMLGDKQGGRVNKHQQKKMIEQYSDNVSLSNSLADALKAAMNKQDND
(648) DNA topoisomerase [Paenibacillus sp. JDR-2]
7
MKTLIIAEKPDMGRTIAAVVEPKAANKRTYLEGDRFIITWAIGHLVTLAEPDQYDARYKRWNDQDLPIIPDKFKLWPNARTKDQLKTIGELAKRCGRLVNACDAGREGQLIFHLIRQYLKLPQPTDRLWISDLTPETIRKGFDSLRSDEDYAPLTRAARARSEADWLIGMNASRAFTIRHKALLSVGRVQTPVLALLYDRHKEITAFKSDMYYVVKALFDQNGFQYSGIWQGDRITDKAKAEALAAKTQGKPGFIKDYQTAESKEYPFRLHDLTLLQREANGRYGYSAKKTLDIAQALYEKHKAITYPRTNSNYVTEENLPVMQKVLTMLQGSDSYRELANGADRGRVHKGNKAVCNPSKVEDHHAIMPTPKRPSGLSPEEQNIYDMIVRRFLSQYYPPAVYKNHTVLTEVESEIFRTKAKELLELGWKVVLQDQGQAAKKTSKKKSSEKDEAESDDEELLTDKPFAIEPQQGVKCVKSESLEKTTQPPKSFTEGTLLKAMESAGKSMEDDELREAMKDTGLGTPATRAATIERLKQVGYVDLTGKKLEISSKGCAAIELIRGAGVDLLASPEMTGRWEQRLHQISRGEASDDQFIMKVKQFAAMIVDKVRQQRPAAPGTFEERESGGKRGAAGTKRGSRTSKPSGGGRPSSTRSSTSASATATAAPKAASRTAASPTVREPIAACPRAGCSGHIIEGKRGFGCSSFRDGCTFVIWKEQQGKTISIPMVRSLLEKGATSQLTFKRQDGSSTKAKLVLTDRDKGTVSVQGV
(1346) DNA topoisomerase 1 [Paenibacillus sp. JDR-2]
1
MADSLVIVESPAKAKTIGKYLGSKYIVKASMGHIRDLPKSQTGVEVENGFQPKYITIRGKGSVLKELKDASKKVKHVFLAADPDREGEAIAWHLAHYLELDETDTCRVVFNEITKQAVKDAFKTPRKINMDLVNAQQARRILDRLVGYKISPLLWKKVKKGLSAGRVQSVCVKLIIDRENEIDAFIPEEYWSITAKLTQQGVPFEAKYHSIKGEKRELHNEEEMQAILAALSGNQFKVAEVKEKERLRNPAPPFITSSLQQEAARKLGFRASKTMSVAQQLYEGVELGKEGTVGLITYMRTDSTRISPVAQEEAKEYIEGKYGPSFYPEQPRVYTKKNSNAQDAHEAIRPTSTLRDPESMKPFLSRDQFRLYKLVWERFVSSQMASAVLDTMTVDLASGDVTFRASGSKIKFAGFMKVYVEGNDDGTEEEHKFLPPFAIGDVVTSDSIEPKQHFTQPPPRYSEARLVKTLEELGIGRPSTYAPTLETIQKRGYVAIEEKKFIPTELGDLVNQLMEEFFPEILDSEFTAKMETDLDHVEDGMEDWVRVLSQFYESFEKRLEVAEEEMKEVEIQDEVSDEICEKCGRHMVYKMGRFGKFLACSGFPDCRNTKPIVKDIGVTCPKCGEGKIIERRSKKGRIFYGCDTYPACDYVSWDKPTNKPCPNCDSMLVEKRNRSGAKLQCPNCDYSEEISEDEQEQA
(109) DNA topoisomerase 1 [Listeria monocytogenes M7]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLELDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVNGKKKKLSTADDVKEVMSAIKGKSFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEASNYIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSAMRSPQEVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVKTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFIPTELGEIVNEMIEDYFPEILDVKFTANMESELDEVEHGEVEWVKVIDEFYKRFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVYKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERACPKCEKRALVEKKLKKGVQVQCTNCDYKESTQQ
(758) DNA topoisomerase 3 [Listeria monocytogenes M7]
2
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDSKYKNWNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDYAKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYYSAVARSEADWVVGINATRALTTKYNAQLSCGRVQTPTLAMIQYREEEIRNFKPREYYGITALTEQESFTWNNGQTFDKALAEKLVKSLQGENAVITDVSMKEKKNFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERHKVLTYPRTDSRFISTDIVPTLKERLAACGVGENAKAARQISGKPIKANKSFVDNSKVSDHHAIIPTEQPVSLGDLSDKERKIYDLVVKRFLAVLSDPYIYEETSVKAKIGQEEFTLKGKVVKSLGWKSIYGESREPDQLTKMKKGDTIPVKRINLETGKTKPPARFNEATLLSAMENPSKYMETTSKALAKTLGETGGLGTVATRADIIEKLFNSFSLEKQGKDIQITSKGRQLLELVPEDLKSPELTARWEQKLSKIAKGELDYRKFTAEMRDYAKKAVTEIKQNDKKFRHDNITSQKCPDCGKPMLKVKGKRGTMLVCQDRECGHRESVSRTTNARCPNCHKRMEMRGEGDKQIFVCVCGHREKLSAFQQRRDKQKNKNVSKTDVAKFMKKQNKQEDEPFNNPMAEALAKLKLDK
(1003) DNA topoisomerase 1 [Listeria welshimeri serovar 6b str. SLCC5334]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLELDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVEGKKKKLSTADDVKEVMSAIKGKTFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEAGNFIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSAMRSPQEVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVKTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFVPTELGEIVNEMIEEYFPEILDVKFTANMESELDEVEHGEVEWVKVIDEFYKQFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVYKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERACPKCNERALVEKKLKKGVQVQCTNCDYKESTQQ
(277) DNA topoisomerase 3 [Listeria welshimeri serovar 6b str. SLCC5334]
2
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDSKYKNWNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDYAKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYHSAVARSEADWVVGINATRALTTKYNAQLSCGRVQTPTLAMIQHREEEIRNFQPREYYRITAQTEQECFTWNIGQTFDKALAEKLVKSLQGENAVITDVSMKEKKTFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERHKVLTYPRTDSRFISTDIVPTLKERLTACGVGENAKAARQISGKPIKANKSFVDNSKVSDHHAIIPTEQPVSLGDLSDKERKIYDLVVKRFLAVLSDPYIYEETSVKAKIGQEDFTLKGKVIKSLGWKSIYGEAREPDQLTKMKKGDTIPVKRVNLETGKTKPPARFNEATLLSAMENPSKYMETTNKALAKTLGETGGLGTVATRADIIEKLFNSFSLEKQGKDIQITSKGRQLLELVPEDLKSPELTARWEQKLSKIAKGELDYRKFTAEMRDYAKKAVTEIKQNDKKFRHDNITSQKCPDCGKPMLKVKGKRGTMLVCQDRECGHRESVSRTTNARCPNCHKRMEMRGEGDKQIFVCVCGHREKLTAFQQRRDKEKNKNVSKTDVAKFMKKQNKQDEEPFNNPMAEALAKLKLDK
(581) DNA topoisomerase 1 [Listeria ivanovii subsp. ivanovii PAM 55]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLDLDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVNGKKKKLSTADDVKEVMSAIKGKSFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEAGNYIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSSMRSPQAVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVRTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFIPTELGEIVNEMIEEYFPEILDVKFTANMESELDEVEHGQVEWVKVIDEFYKQFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVYKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERACPKCNERALVEKKLKKGVQVQCTNCDYKESTQQ
(463) DNA topoisomerase 3 [Listeria ivanovii subsp. ivanovii PAM 55]
2
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDPKYKNWNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDYAKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYHSAVARSEADWVVGINATRALTTKYNAQLSCGRVQTPTLAMIQHREEEIRNFKPREYYGITALTEQECFTWNNGQTFDKALAEKLVKSLQGETAVITDVSMKEKKTFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERHKILTYPRTDSRFISTDIVPTLKERLQACGVGENAKAARQISSKPIKANKSFVDNSKVSDHHAIIPTEQSVSLGDLSDKERKIYDLVVKRFLAVLSDPYTYEETSVKAKIGQEDFTVKGKVVKSLGWKSIYGETREPDQLTKMKKGDKIPVKRVNLETGKTKPPARFNEATLLSAMENPAKYMETSSKALAKTLGDTGGLGTVATRADIIEKLFNSFSLEKQGKEIQITSKGRQLLELVPEDLKSPELTARWEQKLSKIAKGELDYRKFTAEMRDYAKKAVLEIKQNDKKFRHDNITSQKCPDCGKPMLKVKGKRGTMLVCQDRECGHRESLSRTTNARCPNCHKRMEMRGEGDKQLFVCVCGYREKLSAFQERRDKQKNKNVSKTDVAKFMKKQNKQEDEPFNNPMAEALAKLKLDK
(39) DNA topoisomerase 1 [Listeria seeligeri serovar 1/2b str. SLCC3954]
1
MADYLVIVESPAKAKTIEKYLGKKFKVKASMGHVRDLPKSQMGVDTEHDYEPRYITIRGKGPVLKELKQAAKKAKKVYLAADPDREGEAIAWHLANSLDLDQSDKLRVVFNEITKEAVKESFKTPRKIDMDLVNAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSIALRIIIDREKEINNFKPEEYWTIDGNFLKGKKKFQANFYGVNGKKKKLSTADDVKEVMSTIKGKTFDVTDVTKKERLRNPAAPFTTSSLQQEAARKLNYRTRKTMMLAQQLYEGITLGKQGTVGLITYMRTDSTRIADSAILEAGNYIKETYGPEFSRNHKRSDKNAKGAQDAHEAIRPTSAMRSPQAVKEYLTRDQLRLYRLIWERFIASQMTPAVLDTMRVDLDNNGVNFRANGSKIKFHGFMKVYVESNDDNTEEKENILPDLKKGDKVQSESLEQRQHFTQPPPRYTEARLVKTLEEIGIGRPSTYSPTLDTIQRRNYVSLTNKRFIPTELGEIVNEMIEEYFPEILDVKFTANMESELDEVEHGQVEWVKVIDEFYKQFEPNVIKADAEMEKIEIKDEPAGIDCDLCGAPMVFKMGKYGKFLACSRFPDCRNTKAIVKEIGVTCPKCEKGHVIERKSKKKRIFYGCDRYPDCDYVSWDKPVERVCPKCNERALVEKKLKKGVQVQCTNCDYKESTQQ
(595) DNA topoisomerase 3 [Listeria seeligeri serovar 1/2b str. SLCC3954]
2
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDPKYKNWNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDYAKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYHSAVARSEADWVVGINATRALTTKYNAQLSCGRVQTPTLAMIQYREEEIRNFKPREYYGIKALTDQECFTWNIGQTFDKALAEKIVNSLKGETAVITDVSMKEKKTFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERHKILTYPRTDSRFISTDIVPTLKERLQACGVGENAKAARQISSKPIKANKSFVDNGKVSDHHAIIPTEQSVSLGDLSDKERKVYDLVVKRFLAVLSEPYIYEETSVKAKIGQEDFTLKGKVVKSLGWKSIFGEAREPDQLTKMKKGDKLPVKQINLETGKTKPPARFNEATLLSAMENPSKYMETSNKALAKTLGDTGGLGTVATRADIIEKLFNSYSLEKQGKDIQITSKGRQLLELVPEDLKSPELTARWEQKLSKIAKGELDYRKFTAEMRDYAKKAVSEIKQNDKKFRHDNITSQKCPDCGKPMLKVKGKRGTMLVCQDRECGHRESLSRTTNARCPNCHKRMEMRGEGDKQLFVCVCGYREKLSAFQERRDKQKNKNVSKTDVAKFMKKQNKQEEEPFNNPMAEALAKLKLDK
(533) DNA topoisomerase 1 [Bacillus anthracis str. CDC 684]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(895) DNA topoisomerase [Bacillus anthracis str. CDC 684]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLDTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTEIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDESDTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYDGKWEKDNESRLQDPDMANKIAAFCQGKPAVVKEMKTERKEFQPPLLFNLSSLQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFDEYKGLLPAPVESIMNNKRYVNEKKVTDHYAIIPTEQVTNPSRLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTIVTLVDERAEFISKGKQQIQEGWRKVIFQDDKDDETILPIVAEGEEGKVVKVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVKKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGTASPATFMEQTKKLSAKIIEDAVEMSEKWDFTGLHVESIERKGSKFTTGKKVGSCKKCDGDVIDKSTFYGCSNYNTTQCDFTISKKILSKTISQKNMTKLLKGEKTDLIKGFKKGEKTFDAKLEWKDNKINFVFEN
(12) DNA topoisomerase 3 [Bacillus anthracis str. CDC 684]
2
MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
(908) DNA topoisomerase III [Exiguobacterium sibiricum 255-15]
7
MQLIIAEKPKQAEKLAAPYPSVKRDGYIEIKPCDRFPAGAKLAYAVGHLCELQEPAHYDAKWKRWNYDHLPIIPERFDYRLSRGKSKTFQVIKKLLNERTTTSIIIASDAEREGEAIVRLILRLANNAKPIQRLWISSLTPQAVDHGFANLLDGKETENLFHEAMSRACADWLIGMNASRAYTTLLKKKGIADVFSLGRVQTPTLSLIVEREKQIENFRPETFFEVEADFTRYTGKYINPKKQTKITERSLAEAIVARTTGTGTVAAVEKTEQVEKPPFWFSLSLLQTEASRRFGLGAKETLDIAQKLYIRGWISYPRTDSSFVSKDEASQFPAILNRLLKQPEYTELTDLVTNNLMNNKRYVNSAKVSDHYAIIPTEEAGAVAKLSGRDAQVYDLIVRRFLAAFAADARSEKTEIITEREQDRFLTKGSRSLELGFKKVLKIEAKEQELPAVEVGQPVPIKGAKLLEKQTEPPKRYTEGTLILGMKTAGKVLENELQAIMKEIEGLGTEATRAGIIDGLKRREYIQVKKKELHPTAKGRILIEAVSGSILASPEMTAKWESRLDQIGKGEASAAQFVDQAKKLSQHLVQDAKTRVEQLEVDPTQVPAKRARGATNRPVGICPVCQAELLDRGKFYGCSAYQKNNCGFTLPKTILGARLTQTELKKMLANGKTKPLEMKKNGRTFQAMLYLEQHQLKFEFVKGEA
(567) DNA topoisomerase 1 [Exiguobacterium sibiricum 255-15]
1
MAKYLVIVESPAKAKTIKRYLGSNYTVKASMGHVIDLPKSQMGVDVEHDYEPKYITIRGKGPVLKELKTAAKKAQKIYLAADPDREGEAIAWHLAKALGVDESTECRVVFNEITKDAIKDSFKRPRKINYDLVDAQQARRILDRLVGYSMSPLLWKKIKKGLSAGRVQSVAVKMIIDREQEINAFLPEEYWTIKLELDANGEKLEANFYGIDGKKRELHSEEEVNEVLAKLSKSFTVDSVTKKERRRNPALPFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIELGKEGTVGLITYMRTDSTRTSETANLEAHGFIENAYGKEYIAVEKRKEKKAANSQDAHEAVRPTSTMRDPQLVKSYLSRDQFRLYKLIWERFVASQMAPAVLDTVKVDLVSNDVMFRANGSTVKFAGFMKVYIEDTDDETVTDVKDGLLPALEDGEVLEQEMIEPKQHFTQPPPRYTEARLVRAMEELGIGRPSTYAPTLDTIQKRGYVTLEEKKFLPTELGELVIDMISDYFQEFITVQFTADMEALLDAIEKGDMQWTEVVDPIYKSFEKRLTRAEAEIEKIEIKDEPAGEDCEVCGHAMVIKMGRYGKFMACSNFPECRNTKPIQVEIGVKCPTCGTGEIVERRSKKGRLFYGCSNYPECEFVSWDKPVEEPCPVCSSMMVQKKIKNGVKVECTSCGHHETRIDQEQEEE
(295) DNA topoisomerase 1 [Bacillus weihenstephanensis KBAB4]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKYPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREKEIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNEAQVNEIIEKMKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARDYITEAFGAEYIGTEKRKETKKSKAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTAKLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDIEPKQHYTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVALDNKRFVPTELGGIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCSHPMVFKMGKYGKFMACSNFPECRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(222) DNA topoisomerase [Bacillus weihenstephanensis KBAB4]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLNTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTEIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDEADTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYEGKWEKDNESRLNDPDLANKIAAFCQNKPAVVKEMKTERKEFQPPFLFNLSALQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFDEYKGLLPAPIESIMNNKRYVNEKKVTDHYAIIPTEQVTNPSKLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTITTLVDERAAFISKGKQQIQEGWRKVIFQDDKDDETILPIVAEGEQGKVGKVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVQKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGTASPATFMEQTKKLSAKIIEDAVEMSEKWDFTGLHVESIERKGSKFTTGKKVGNCKKCDGDVIDKSTFYGCSNYNTTQCDFTISKKILSKAISQKNMTKLLKGEKTDLIKGFKKGEKTFDAKLEWKDNKINFVFEN
(577) DNA topoisomerase 3 [Bacillus weihenstephanensis KBAB4]
2
MAKSIVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKQWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIIATDAGREGELVARWIIDKVKMQKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIASREDEIKHFKAQTYYGIEAQTAERLKLTWQDTKGNSRSFNKEKTDAIVNKISKQNATVVDIDKKQKKSFAPGLYDLTELQRDANKIFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPVKSNKSFVDDSKVSDHHAIIPTESYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKIGDETFIARGKTILHAGWKEVYENRFEDDDASDDVKEQILPRIEKGDTLNIKLIVQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLLEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVAEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGSKADKRDVQKYMKQQNKEEEPLNNPFAEALKKLKFD
(940) DNA topoisomerase 1 [Bacillus pseudomycoides DSM 12442]
1
MESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIDREKEIQSFIPEEFWTIKTEFVKGKDTFEASFYGVNGEKVQLTNEAQVKDIIETMKNNAFSVENVTKKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDIGKQGTVGLITYMRTDSTRISETAQEEARSYITEAFGSEYIGTEKKKETKKANAQDAHEAIRPTSVMRKPEELKSFLSRDQHRLYKLIWERFVASQMASAVMDTVTARLINNNVQFRASGSVVKFSGFMKVYVESKDDGAEEKDKMLPPLEIGETVFSKDMDPKQHFTQPPPRYTEARLVRMLEELGIGRPSTYVPTLETIQKRGYVALDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQNLDEVEEGKANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCGHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(1583) DNA topoisomerase [Bacillus pseudomycoides DSM 12442]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLDTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTGIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDEADTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYEGKWEKDNESRLKDPDMANKIAAFCQNKPAEVKEMKTERKEFQPPFLFNLSSLQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFEEYKDLLPAPIESIMNNKRYVNEKKVTDHYAIIPTEQATNPNKLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTITTLVDSRAEFISKGKQQIQEGWRKVIFQDDKEDETILPIVVEGEQGKVVTVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVKKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGIASPATFMEQTKKLSAKIIEDAIEMSEKWDFTGLHVESIERKESKFTTGKKVGKCKKCDGDIIDKSTFYGCSNYNTTQCDFTISKKILGKTISQKNMTKLLKGEQTDLIKGFKKNDKTFDAKLEWKENKINFVFEK
(1608) DNA topoisomerase 3 [Bacillus pseudomycoides DSM 12442]
2
MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGNKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLIRKDVTEIIVATDAGREGELVARWIIDKVKINKPIKRLWISSVTDKAIKDGFANLKPGKAYENLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAIIAGREDEIKNFKAQTYYGIEAQTTDKLKLTWQDGKGNGRSFDKAKIDTIVKKLDKQNATVTEIEKKQKKSFAPGLYDLTELQRDANKIFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKILNKPIKSTKAFVDDSKVSDHHAIIPTESYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKIGDETFVARGKTILHSGWKEVYENRFEDDDAVEDLKEQILPRIEKGDTLSVKLIAQTSGQTKPPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTAEWEQKLEAIAKGKLKKEIFISEMKNYTKEIVAEIKSSDKKYKHENISTKTCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGDGQIFACKCGYREKLSTFQERRKKESGNKADKRYVQKYMKQQQKEEEEPLNNALAEALKKLKFE
(990) DNA topoisomerase [Geobacillus thermoglucosidasius C56-YS93]
7
MKVIIAEKPDQGATLASIFQTKKHQGYIEIYPNELFPKGAYMTWAVGHLFQLVPPEWYRPEWKQWKLETLPIIPERFQYEVERAKAKQFAIVKELLRKPEVTEIIHAGDAGREGELIVRNIIHMSGVKKPMKRLWLSSLTPKAIYEGFRQLLDEAETRNLYEEAYARACADWLVGMNASRVYSILLKQKGMNDVFSVGRVQTPTLAFIVKREKEIEQFRPEPFWEVVAAFAVNGKQYEGKWTNEEGETRIKEEQLAQKIAQFCRNKLAEIHEVKTERKTFLPPLLFNLSSLQATANKMYQFSPKKTLDILQNLYQKGIVSYPRSDSNYVTKGEAETFPDILQKLRAFSDYQPFFPLPNALILHNKRYVNEKKVTDHYAIIPTEQVVDPAKLPADERKIYDLIVRRLIAAHYEAAVFDFTTVITLVDGRARFVSKGKQQIQEGWRKVISPREDDDGALLPLLHEGEQGDVLNVRVKVGKTQPPKRYTEGQLITLMKTAGKFLDNEELEKVLAKTEGLGTEATRAAIITTLKERNYIEVRKNQVYATDKAKVLIEAIGDKILASPEMTAKWEQRLSEIGEGKASAAQFMEQVKKLSAKIVQDAVEMSETWDFAGLDTASIQRTTSKAALGKPVGPCKLCGGTVIDKGAFYGCANYAKTKCPFAISKKILGKTVSRANVKKLLEHGRTGVIKGFKKEGKTFDAALVWDEKEKKITFSFAKK
(1342) DNA topoisomerase 1 [Geobacillus thermoglucosidasius C56-YS93]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDINNGYEPKYITIRGKGQIIKELKTAAKKAKKVFLAADPDREGEAIAWHLANMLELDIHSDCRVVFNEITKDAIKESFQHPRAIDMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIKQFQPEEYWTIQAEFVKGNETFTASFYGADGQKLDLKNEADVSAILRRINGNHFTVTSVAKKERKRNPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVSESAQQEALSYIEATFGKEFAAQEKRKEKKSANAQDAHEAIRPTSVFRDPEKVKPYLTRDQFRLYKLIWERFVASQMAAALLDTMSVELENGGVIFRANGSKVKFPGFMKVYVEGTDDQTDEQDRLLPDLQEGETVFSKDIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTIDTIQKRNYVVLENKRFVPTELGEIVVELILEFFPEIIDVEFTAKMEKNLDEIEEGKVQWVKVVDEFYREFEKRLQIAEKEMKEVEIKDEPAGVDCEVCGSPMVYKMGRFGKFVACSNFPECRNTKPIVKEIGVKCPKCHEGNIVERSSKKKRIFYGCDRFPQCDFVSWDKPLARRCPKCEGVLVEKKLKKGVQVQCTSCDYEEEPQS
(1299) DNA topoisomerase 1 [Geobacillus thermoleovorans CCB_US3_UF5]
1
MSDYLVIVESPTKAKTIERYLGKKYTVKASMGHVRDLPKSQMGVDIDHGYEPKYITIRGKGQVIKELKTAAKKAKKVFLAADPDREGEAIAWHLAHMLDLDIHSDCRVVFHEITKDAIQQSFQQPRAINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREREIREFQPEEYWTIQATFQKEGETFAASFYSIDGQKRDLKTEADVKAVLDRLNGTAFAVKTVTKRERKRSPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVAETAQQEAAAYIEATFGAMYVNQEKRKEKKSTNAQDAHEAIRPTSAFRDPDKVKPYLTRDQFRLYKLIWERFIASQMAAAVLDTMSVELENNGVVFRASGSKVKFPGFMKVYIEGTDDQTEEQDRILPDLEEEETVESETIESKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVVELMLEFFPEIIDVEFTAKMEKELDEIEEGKVEWIKVVDEFYREFEKRLKVAEKEMRAVEIKDEPAGIDCEVCGSPMVYKMGRFGKFIACSNFPECRHTKPIVKEIGVKCPKCREGNIVERSTKRKRVFYGCDRFPDCDFVSWDKPLARPCPKCAGLLVEKVLKKGVQVQCTACDYEERLEA
(1063) DNA topoisomerase [Geobacillus thermoleovorans CCB_US3_UF5]
7
MKVIIAEKPDQGATLASIFRTKKRQGYIEILPNDLFPDGAYMTWAIGHLFQLAPPERYRPEWKRWTLNTLPIIPERFEYEIEKAKAKQFQVVKELLRKPEVTEIIHAGDAGREGELIVRNLIRLSGVNKPMKRLWLSSLTPKAIEEGFRRLLDEQTTRPLYEEAYARACADWLVGMNASRVYSLLLKERGMNDVFSVGRVQTPTLALIVRREREIEQFRPEPFWEVVASFVIGDKRYEGKWTDKNGQTRLGDEEMAKKIAAFCQGKRAEVADVRTERKTYQPPLLFNLSTLQATANKLYRFSPKKTLDVLQSLYQKGIVSYPRSDSMHVTKGEAETFPAILQKLSSFPAYAPYFPLPQPSILQNKRYVNEKKVTDHYAIIPTEQVVAPEKLSDDERKVYDLVVRRLIAAHHQAAVIDYTTVTTLVDGRARFVSKGRQVVEEGWRAVIRPHEEEKDAALPPLERGEAGKAAAVKVKEGKTEPPKRYTEGELITLMKTAGKFLDDEELEKVLAKTEGLGTEATRAAIITMLKERKYIEVKKNLVYATDKAKVLIEALGGTILASPEMTAKWEQRLSEIGEGSASPAAFMEQVKKLAQKVVADAIAAAPNWNFRGVDTASIQRTRKKKTMGEKLGPCPLCGGTVIDKGTLYGCDQYAKTKCSFTISKRILGKSISAANVKKLLAQGKTNVIKGFKKGGKTFDAILVWDENEKKLSFQFPKR
(1298) DNA topoisomerase [Geobacillus thermoleovorans CCB_US3_UF5]
7
MKSLVLAEKPSVARDIARVLGCKQAHKHYFEGKQHIVTWALGHLVELKMPEDYDRKYETWRLEDLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIATDAGREGELVARWILEMIGWTKPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVCRAEADWLIGLNVSRALTTKYNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKIGSITAVWERHGGHRLFDQDEAKQLIARLDGQPARVVSVKRKRKSEPAPLPYDLTELQRDANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMEATMTERLLAMKSGYEDVIAPLLAKGKAKAAKRVFNDDKVTDHHAIVPTDERLNLSRLSTDERKLYDLIARRFLALFFPPYESETTTAVFDIGGEMFVAKETAVVNFGFKAVLGKEETDAKPTLSHLAEGQTLPSVQLEREQSFTEPPARYSEADLLAQMEKYGLGTPATRADIIERLVETEVVERKDGRFYPTKKGKQLIELVNEELKSPELTARWERELEAIARGKGNPQQFLANIRRQTETLVAEIKQSEQVYKAPNLTNLTCPECGALLKERKTKDGRMLVCSNLACRYRRRRDPKLSNRRCPQCHRRMEMHEGKAGMYFQCRPCNIVEKADETKRIAAKGSERALLKKYSPANESFGTSLGELLKQALNEKKE
(558) DNA topoisomerase 1 [Bacillus thuringiensis serovar konkukian str. 97-27]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEIEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(1090) DNA topoisomerase 3 [Bacillus thuringiensis serovar konkukian str. 97-27]
2
MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
(1561) DNA topoisomerase 1 [Streptococcus mutans UA159]
1
MTSKTTTTVKKTSKKRATPKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKNAKQIFLASDPDREGEAISWHLAHILDLDLKGKNRVVFNEITKDAVKNAFVEPRQIDMDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWSIDGFFKKGNKKFQANFYGLDNKKTKLKSNDDVKKVLTRIKNDDFLVDKVEKKERKRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIRLGSNGQQGLITYMRTDSTRISPVAQNDAANYITEHFGAEYSKHGNHVRNASGAQDAHEAIRPSNVNHTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLTQNGVLFIANGSQIKFKGYMAVYNDSDKTKVLPEMIKGETVKKISANPEQHFTQPPARYSEASLIKTLEENGVGRPSTYAPTLETIQKRYYVRLVSKRFEPTELGEIVNSLIIEFFPDIVDVKFTAEMESKLDEVEIGKEEWQKVIDQFYKPFEKEVIKAEEQMEKIQIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVICPICQKGQVIERKTKRNRIFYGCDRYPDCDFTSWNKPIGRDCPKSGDFLVEKKIRGGGKQVVCSNEECDYKEKAVK
(760) DNA topoisomerase 1 [Streptococcus suis ST1]
1
MATKTVSKKKTTTKKNLVIVESPAKAKTIEKYLGKNYKVVASVGHIRDLKKSSMSIDFDNNYAPEYINIRGKGPLINSLKKEAKNAKQVFLASDPDREGEAISWHLAHILGLDANDKNRVVFNEITKDAVKNAFQEPRAINLDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEISNFKPEEYWTIDATFKKGSKKFQASFYGIDGKKTKIENNEQVKEILARLDGDDFLVEQVERKERKRNAPLPYTTSTMQMDAANKINFRTRKTMMVAQQLYEGVSLGTGGTQGLITYMRTDSTRISPVAQAQAADFITERFGATYSKHGNKVKNASGAQDAHEAIRPSNVNLTPESIAKYLDKDQLRLYTLIWNRFVASQMAAAVFDTMSVRLGQNGIVFAANGSQVKFDGYMAVYNDADKNKMLPDMEQGDTVVRASTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVKLAAKRFEPTELGEIVNKLIVEFFPDIVNVKFTADMEQKLDDVEIGKEQWQKVIDGFYQPFKVELSKAEEQMEKIQIKDEPAGFDCDVCGHEMVIKLGRFGKFYACSNFPDCRNTKQITKEIGVTCPVCQKGQVIERKSKRNRLFYGCDRYPECEFTSWDKPVGRSCPKCDHYLVEKKVRGGGKQVVCPNGDYEEDKIK
(1201) DNA topoisomerase 1 [Streptococcus thermophilus JIM 8232]
1
MATATTTKTKAKKKTKAKKATKKRATPKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLIKELKKEAKKAKKVFLASDPDREGEAISWHLSHMLGLEPEDKNRVVFNEITKDAVKNAFAEPRAIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGAFKKGAKKFQASFYGLDGKKLKLNNNDDVKDVLSRIISDDFNVDKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGINLGSGAQGLITYMRTDSTRISPVAQNQAAEFITERFGSKYSKHGSKVKNSSAAQDAHEAIRPSNVFQTPESIAKYLDKDQLKLYTLIWNRFVASQMAAAVFDTMKVTLSQNGVIFTANGSQIKFDGYMAVYNDSDKNKMLPEMAEGDTIKKVVTTPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVKLVAKRFEPTELGEIVNSLIVEFFPDIVDVKFTAEMEAKLDKVEIGKEQWQKVIDEFFKPFQKELEKAEEGIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVTCPTCGQGQVIERKTKRNRVFYGCDRYPDCEFTSWDIPIGRNCPKSGDYLVEKKVRGGGKQVICSKEECDYKESVIK
(233) DNA topoisomerase 1 [Bacillus cereus ATCC 10987]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMNLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIERLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAFGTEYIGTEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(828) DNA topoisomerase 3 [Bacillus cereus ATCC 10987]
2
MSKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGRAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVMEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSKFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
(1013) DNA topoisomerase 1 [Streptococcus sanguinis SK36]
1
MSKLVTKTKKKSTTKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSTMSIDFENNYEPQYINIRGKGPLINDLKKEAKKAKQVFLASDPDREGEAISWHLAHILNLDEKEKNRVVFNEITKDAVKNAFKDPRQIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEINAFKPEEYWTIDGTFKKGTRQFQASFYGMNGKKMKLTNNEYVKEVLSHLKGDDFTVDSVEKKERRRNAPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDKFGAKYSKHGSKAKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMNVKLGQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMEKGDTVKRVNTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVKLVSKRFEPTELGEIVNSLIVEFFPGIVNVKFTAEMEAKLDDVEVGKEQWQKVIDEFYRPFEKEVAKAETEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVTCPQCQKGQVIERKTKRNRIFYGCDRYPDCDFTSWDKPVGRNCPKCDHYLIEKKVRGGGKQVVCSNGDYEEEKVK
(545) DNA topoisomerase 1 [Lactobacillus gasseri ATCC 33323]
1
MPTKRKNKKNLVIVESPHKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGVDVEHDYEPKYISIRGKGDTIKELKSEAKKAKYVYLASDPDREGEAIAWHVAHALNLDPKEHNRVAFNEITKDAVKNAFKNPRTIDMDIVDAQQARRVLDRLVGYSISPILWQKVKKGLSAGRVQSIALKLVIDRENEIKNFKPEEYWTIDADFEKGKEKFKGAFYGIKGKKQDLPNNEAVQDILKQIDKRKNFEVTKVVKKERRRQPAAPFTTSTMQQEANKRLGYRTRRTMRIAQSLYEGVNLGKGSVGLITYMRTDSKRIANVAKHEASKFIHEEYGANYAAIKPQHFKNDADAQDAHEAIRPTSAFRTPASVKEYLTTEEYRLYTLIWSRFIASQMTPAVYDTVRADIEQNDVTFRTTGSKLKFAGFTKVYDNQKEKNNELPELNEGDKVKLKKTDDRQHFTQPPARYTEASLVRALEENGVGRPSTYAPTIDTIQKRYYVKLEGRSIVPTELGEIVDKLIEEFFPDIVNVDFTAQLEDDLDGVEVGKKNWIKVVDEYYKPFSKELDKADQQIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKVGVTCPKCGKGEVIEKKSKRNRKFYGCSRYPDCDFVSWDQPIGRNCPNDGHFLVQKKNKKGLVILCPNGDYREEPEEN
(1488) DNA topoisomerase [Streptococcus infantarius subsp. infantarius CJ18]
3
MKYLLLAEKPDQAKKYANALGNPKKDKGVWRVQSSVLNAEVIVAPAVGHLVERINPYTNFENWEMANLPALPDGFAYEPKKDTAKRFKAIKQSVKEVDAIIIGTDPDREGEAIAYRILELIPGALRKIKYRLWANSLTKKGLEQAFSKLKNPKDSINYFHEADARGDADWLVGFNLSPFVTIKMKEEGYLDKKEHSMSVGRVQTPIVSLVVRNDEAIENFKPSPYWQLKLIDPEAKVTFGNDIKYQSKAEAEQMLQQLANIAVVKTVTSEEKVQEAPELYNLTNFQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFAYLVEHIEDYQKAINKHLETPNRSPRKNYVNDKKVLEHYAIIPTETIPDLSELSNDEKLIYQKVVFRTLLMFTPDYRYQSTSVILDNQGLEFKATGAVTKDKGWRNYLAVKKEDKELPDYQEGQTITIECKLLEEMTKPPTRITEQILLKKLLPKYNLGTSATRDGMIDLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVNKIKWAITKQIEKGKQL
(263) DNA topoisomerase 1 [Streptococcus infantarius subsp. infantarius CJ18]
1
MATTTTKAQTAVKKTSKKTTKKKTAAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINDLKKEAKKSKKVYLASDPDREGEAISWHLAHILGLDENEKNRVVFNEITKDAVKNAFVEPRQIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIRNFKPEEYWTIDGFFKKGTKKFQAAFYGIDGKKLKLSTNEEVQEVLARLTSDEFNVAKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGISLGKSGTQGLITYMRTDSTRISPVAQNDAAGFITERFGENYSKHGNRVKNASGAQDAHEAIRPSNVNLTPESIAKHLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVNLEQNGVRFTANGSKVKFDGYLAVYNDSDKNKMLPDMVEGDVVKKVSTSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVRLVSKRFEPTELGEIVNNLIVEFFPDIVDVKFTADMEGKLDEVEEGKEQWQKVIDAFYKPFEKELAKAETEIEKIQIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVTCPICGEGQVIERKTKRNRLFYGCDRYPECEFTSWDKPVGRSCPKCGQFLVEKKIRGGGKQVVCSSEECDYEEAKVK
(1599) DNA topoisomerase 1 [Streptococcus mitis B6]
1
MATATKKKKSTAKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTIDGVFKKGTKQFQASFYGVDGKKLKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDYDKNKMLPDMAVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVDYFPDIVNVTFTAEMEGKLDDVEVGKEQWQRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCSSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPDCEFTSWDKPVGRDCPKCGHFLMEKKVRGGGKQVVCSKGDYEEEKIK
(1763) DNA topoisomerase 1 [Streptococcus oralis Uo5]
1
MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILDLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEINAFQPEEYWTIDGVFKKGTKQFQASFYGMNGKKMKLTTNEEVKEILSHLTSKDFTVDQVDKKERKRNAPLPYTTSTMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASYINDRFGSKYSKHGSKIKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTGAIFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMAVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWQRVIDAFYKPFSKEVAKAESEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGNSMLVAISQTAVTHKLLSKRLESSVQAVIKDKSSNEKPSVIVSSMVAIAIQNVNLLPGTNQLDVIVQNADTSLWRKRSVAVVNRLYVVMATTKKRKLNNTKSPENKFQALFT
(240) DNA topoisomerase 1 [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
1
MGTKTTTKPKTGTKKSTTKKKSAAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHILGLDPEDKNRVVFNEITKDAVKNAFVEPRQIDMNLVDSQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFVPEEYWSIDGLFKKGTKKFQASFYGLDGKKMKLSNNDDVKAVLAKLKGDDFLVSKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIHLGENGTQGLITYMRTDSTRISPVAQNDAAQFISNRFGANYSKHGNRVKNTSGAQDAHEAIRPSSVNHTPEAIAKYLNKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLEQNGVLFVANGSQMKFDGYMAVYNDSDKNKMLPEMEEGETVKKVSTSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVAFTAEMEGKLDQVEIGEEEWQHVIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGHPMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPICHKGQVIERKTKRNRIFYGCDRYPECDFTSWDLPVGRDCPKSGDYLVEKKVRGGGKQVVCSNETCDYKEEKIK
(1809) DNA topoisomerase 1 [Geobacillus sp. WCH70]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDINNGYEPKYITIRGKGPIIKELKTAAKKAKKVFLAADPDREGEAIAWHLANMLDLDIHSDCRVVFNEITKDAVKESFQHPRPINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIKQFQPEEYWTIQAEFVKGNETFTASFYGVDGQKLELKKEADVAAILQRINGNHFTVTSVAKKERKRNPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVSESARQEALSYIEATFGKEFVAQEKRKEKKNANAQDAHEAIRPTSAFREPEKVKPYLTRDQFRLYKLIWERFIASQMAAALLDTMSIELENEGVIFRASGSKVKFPGFMKVYVEGTDDQTDEQDRLLPDLQEGETVFSKDIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVLELMLEFFPEIIDVEFTAKMEKNLDEIEEGKVEWVKVVDEFYQEFEKRLQTAEKEMKEVEIKDEPAGVDCEVCGSPMVYKMGRFGKFVACSNFPECRNTKPIVKEIGVKCPKCREGNIVERSSKKKRIFYGCDRFPQCDFVSWDKPLARPCPKCGGLLVEKKLKKGVQVQCTACDYEEAPQS
(860) DNA topoisomerase 1 [Oceanobacillus iheyensis HTE831]
1
MSDYLVIVESPAKAKTIERYLGKKYTVKASMGHIRDLPKSQTGVDVENNFTPKYITIRGKGDVLKELRKAAKKAKKIYLAADPDREGEAIAWHLAYILGVDPSSNCRVVFNEITKEAIKESFKHPRAIDLDLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALKMIIDREKEIQNFKPEEYWSIDAKFQKDKEIFDGSFYGINGKKVALKNEQDVKDIKQQLNGKKFAVDKVKKRERKKNPALPFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKKSGGITGLITYMRTDSTRISNTAKDEAKNYIVDNYGEKYLGKQASTKNKEGAQDAHEAIRPTSALRDPKNLKNILSRDQFRLYKLIWERFVASQMAPAVMDTMTVHLLNNNIEFRATGSKIKFKGFMKVYVEGNDDNKKTEDKLLPELEEGMEVDSKEIKPNQHFTQPPPRYTDARLVRTMEEIGIGRPSTYAPTLDTIQRRGYVTMDNKRFIPTELGEIKCDLMIEFFPEVVDADFTAKMEDDLDSIEEGNIEWKQIIDSFYKDFKVRLDKAEDEMEKVEIKDEPAGIDCENCGHEMVYKMGRYGKFLACSNFPECRNTKPILKEIGVDCPKCEEGNVVERKSKKKRTFYGCDRFPECDFVSWDKPIARKCPKCESMLVEKKNKKETQVQCTNCEYKEVAQT
(400) DNA topoisomerase 3 [Oceanobacillus iheyensis HTE831]
2
MSKTVVLAEKPSVGRDIAKVLGCHKKGNGFLEGSKYIVTWALGHLVTLADPDMYDSKYKTWRMEDLPMLPDHLKLVVMKKTGKQFQSVKTQLNRQDVVEIVIATDAGREGELVARWIIEKARVKKPIKRLWISSVTEKAIKDGFKQLKPGKNYWNLYQSAVARSEADWYVGLNATRALTTKHNAQLSSGRVQTPTLEMVSLREQEIKNFQPKKFYQLEAKTTKGHRFLWKNDENQNRIFSKNEAIKLEEKLSNKQATVVHVDKKLKKKHAQGLYDLTDLQRDANRIFQFSGKQTLSVMQKLYEQHKLVTYPRTDSRHLSTDIVSTLKDRVKACGVDEYAKIANTILNKELRLNKSVVDNAKVTDHHAIIPTEVPVVWTALDDKEKKIYHLIVQRFLAALSDPMEYEQTTITIDIAGEQFIANGKVTKRLGWKEIYKHNDEEDEIQPLNVTKGSKLTLKVELKEGETKPPERFTEGTILQAMENPTRYMGTNKKELVDTIKETGGIGTVATRADIIEKLFMNSYIELKGRNIYLTQTGRQLLDLAPEELRSPLLTAEWEQKLSLIAEGKLKKDQFIKEIKSYTKEAVTEIKQSSETFKHDNMTGTKCPKCGKLMLEIKNKHGKKLVCQDRSCGGKKNIAKFTNARCPNCHKRLELRGEGEGQIFTCKCGHREKLSTFQARKEKEKKQRVSKKDVKKYLNKQDEGFKNNALADALAKLKNDE
(180) DNA topoisomerase 1 [Clostridium sp. BNL1100]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAVKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATKMICDREDEIENFESQEYWSITAKLTKPKASPNFEARFYGIGKEKIELTNEEQVNSILDEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGFTTKRTMMVAQQLYEGIEIKGHGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPENPRVYKNKSASQDAHEAIRPTYMDMAPEGLKEFLSAEQYKLYKLIWDRFISSQMSSAIYDTVAADITAGKYMFKANGSKVKFPGFMVLYIEGNDVEGKDEDGEQNEKENNLPQLNEGDILELKKNTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAQMESELDDVEDGNKEWKAVMRDFYSSFAGVLKEAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNTKPIVEEAGVECPLCKGKVLIKKTKKGKKYIGCERNPECSFMSWDMPSPNKEMCPVCGAFMLQKSSGKKKALKCSNDKCTSNTETSTDTK
(250) DNA topoisomerase 3 [Clostridium sp. BNL1100]
2
MGFTLVIAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFSVQWQDGRTNQTRTFNKEEADGIVAKITGQIGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKISVTKRFVDNSKVTDHHAIIPTEQFVDLSSLNSEERNIYDLIVKRFIAVLSQPFEYEQTTVKLNVAGESFYAKGKIVRSSGWKTVYDGFGKLDEDSDEDDNDQSLPDIQKGHKAKVVAPKAINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERRGKEIYPTSKGTQLISLVPADLKSPELTAKWEQQLSLISKGKANSNAFVGEMKNYAKKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHVCPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGEQVDKKDVARFMRQQDKDESINSALADALAKWKK
(922) DNA topoisomerase 3 [Tepidanaerobacter acetatoxydans Re1]
2
MSKTLVLAEKPSVARDIARVMNCGKNGNGYLEGQKYIITWALGHLVTLAEPEAYGNRYKSWRMEDLPILPKDLKLEIIKQSRRQFNIVKEQMNRNDVNSIVIATDAGREGELVARWIIKMANVKKPIKRLWISSVTDKAIRDGFNNLKDGKQYENLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAMIAKREEEIQNFKPRDFYGITATVGNLKLVWQDSQTRDIRTFDKGKIDRILASLRGKNAEVIDVTKTLKKSFAPQLYDLTQLQRDANKIFGFSAKETLSIMQRLYENHKLLTYPRTDSRFITTDIVATLEDRVKACGVGPYRTAAFKIKRPIKGNKSFVDNGKVTDHHAIIPTEQPAFLDSLSENERKIYDLVVKRFLAAMYPPFEYEQTTIKAKIGTEIFIAKGKTVIALGWKEVYEGFDDESSEDENLNDGIFEQILPTMSKGDILKITSIFQTQGRTRPPAPLNEGTLLAAMENPVKYMPKDNKDLIKVIGETGGIGTVATRADIIEKLFNSFLIEKRGKDIFITSKGRQLLDLVPEELKSPALTAQWEQKLSAIAQGALKKDTFVNDMKNYAKRAVQDIKNSEDKFRHDNLTRSKCPQCGKYMLEVNGKKGKMLICQDRECGYREKLSKVTNARCPNCHKRLELHGEGEGQIFICNCGYREKLSAFNERKASEGNNKVSKRDVAKYLQKQKKDEDKPINTELADALAKLKL
(1026) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(921) DNA topoisomerase 3 [Tepidanaerobacter acetatoxydans Re1]
2
MSKTLVLAEKPSVARDIARVMNCGKNGNGYLEGQKYIITWALGHLVTLAEPEAYGNRYKSWRMEDLPILPKDLKLEIIKQSRRQFNIVKEQMNRNDVNSIVIATDAGREGELVARWIIKMANVKKPIKRLWISSVTDKAIRDGFNNLKDGKQYENLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAMIAKREEEIQNFKPRDFYGITATVGNLKLVWQDSQTRDIRTFDKGKIDRILASLRGKNAEVIDVTKTLKKSFAPQLYDLTQLQRDANKIFGFSAKETLSIMQRLYENHKLLTYPRTDSRFITTDIVATLEDRVKACGVGPYRTAAFKIKRPIKGNKSFVDNGKVTDHHAIIPTEQPAFLDSLSENERKIYDLVVKRFLAAMYPPFEYEQTTIKAKIGTEIFIAKGKTVIALGWKEVYEGFDDESSEDENLNDGIFEQILPTMSKGDILKITSIFQTQGRTRPPAPLNEGTLLAAMENPVKYMPKDNKDLIKVIGETGGIGTVATRADIIEKLFNSFLIEKRGKDIFITSKGRQLLDLVPEELKSPALTAQWEQKLSAIAQGALKKDTFVNDMKNYAKRAVQDIKNSEDKFRHDNLTRSKCPQCGKYMLEVNGKKGKMLICQDRECGYREKLSKVTNARCPNCHKRLELHGEGEGQIFICNCGYREKLSAFNERKASEGNNKVSKRDVAKYLQKQKKDEDKPINTELADALAKLKL
(1025) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(1328) DNA topoisomerase 1 [Clostridium ljungdahlii DSM 13528]
1
MGQKLVIVESPAKAKTIGKYLGKNYVVKASMGHVRDLPKSQLGVDIDNEYTPKYITIRGKGELLDKLRKEAKKSEKVYLATDPDREGEAISWHLSHALKLDENEKCRIEFHEITKNAVKSSIKSARLININLVNAQQARRVLDRLVGYKISPILWRKIKWGLSAGRVQSVALKMICEREKKIVDFVPQEYWTIECELHKENESKCFNVKLTTFNKKKIEIGSKDEVDKIIEELKQGQFIVKSIKNTNKNRTPLPPFTTSTLQQDAYKKLNFSTKRTMSIAQQIYEGVDIKGYGTIGLITYMRTDSVRIAQEAQEACRDFVANKFGKEYIEEKPRNFKSKKNIQDAHEAIRPTNVEITPEIAKENLKPEQYKLYNLIWNRFVASQMSSCQIDVKSIDIVNSNYGLKVSGSRIKFDGFMKVYKYATEEEKSDISLPKLEEGEKLLRKSIDGKQHFTQPPARFSEASLVKTLEENGIGRPSTYAPILSTLLDRKYIQREKKTLIPTELGDIVNNIVSQYFKQVVDVEFTAAMESKLDSVEDGKDDWRKVVGEFYEPLKKSIEIAEKEVARITIEDKVTDIKCDKCGRNMVIKHGRFGDFLACPGYPECKNTKPIVEELDVKCPKCQGKVLIKRSRKGRKFYGCSNYPDCDFVSWFEPTNEKCKECGNYMVKKYNKSKGNYLECSNSECKHREYKAVEDGDEKTAK
(151) DNA topoisomerase [Clostridium ljungdahlii DSM 13528]
3
MKSLIIAEKPSLAMSIVKSIGSMERNNGYFENKNYIVTFAYGHLLQLYDVDDYFGREKTKWTLKELPFVPKEFKFRLRKDEGVKKQYEIIKSLIKRNDVQEIVNCGDADREGEVIVNNIIFRAFEEEHVTKPVKRLWLPEQTRQTIIQSLKDLRDDIEYKNLYDEGLARTYLDWSYGINLTRYLSIKSGSFLPVGRVLIPIVKYVYDRDEKIENFKPETYFEIGAVINKDNLHIKTKLKDRKFAANERDKAEKLLNNLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKEEKMSLDDTLKNLQKLYEAGYTTYPRTNTEYLAENEKDRIKSVIAAVKENFNADISFKDNKKIFNSKKVESHSAITPTIKIPRKEKLSEGEKKVYTAIKNRFISNFLNEETIIEETSVVIKIDDEIIQLKGNVIKSPGFLKYEKSKRENELPQFVEGEELDTKLSVDQKETQKPGRVTESELNNFLKNPFKKQEVEDLEGENDDEEYKLILEGCEIGTVATRAGIIKNAKKYEYIKELKGHLECENKGKKLIEALEKLKIDLNKEKTVEFGKQLKKVYKEEIGINEIIDKVKDELNSIVQNGNKIKIEKLYLYNNKSDSKIKIESIGKCPVCHEGEVVENKSGYGCNRWKEGCKFFVGNKIAGKEILKTHVKKLIKDSKTNVIKGFKGKSGKKFNASLVIDKEGKIVFNFENEVLGKCPCCGHDIVEGKNAFGCSNWKEGCKFTIWKNDKYLACMGKKPTKTMVCELLKNGKVKIKGLKGKDGNIFDAYLMLIKNENENKDKYPYKWKMQITK
(22) DNA topoisomerase 3 [Clostridium ljungdahlii DSM 13528]
2
MGKILVLAEKPSVGREIARVLKCRKKGNGWLEGEKYIVTWALGHLVTLADPEAYDDKYKTWKLEDLPMLPKYLKLVVIKQTGKQFNAVKEQLNRKDVTEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAINEGFRNLKPSSQYDNLYRAAQCRAEADWIVGLNVTRALTCKHNAQLSAGRVQTPTLAMIVHREEEIKNFKPKDYYSIIGNANGYTLQWQNGNGHFNTFDENFANKVVSKVNGQNGKILDVIKSDKKKYAPALYDLTELQRDANRLFGYSAKQTLSIMQRLYENYKFLTYPRTDSRYISADIVPTLPERLKAISVGNYSKFAMEIMRGKIRAHKGFVDDSKVSDHHAIIPTEEKVILSKLSNEERKVYDLVVKRFLSVMLPPFEYVQTTVKAEINGENFAASGKVIKSKGWKAVYDKNEDFDDNDGLHENQLKEQVLPNLNRGDSIKLTAVKMHKGQTKPPARFNEGTLLSAMENPQKYINMNKEYAKTLGETGGLGTVATRADIIEKLFNTFYIEKKGKEIIPTSKGKQVVELVPEDLKSPLLTAKWETDLNLISKGKLNDKSFIGNMRNYSVKLVEDVKGSHDKFRHDNLSGAKCPECGKYMLEVNGKHGRMLVCQDRACGHRENLAKLTNARCPECHKKLELRGHGDGQVYVCINNNCNFREKASSFNKRFDNKQGKNSKRDVANYMKKMKKESEVPMNSALADALAKLKLK
(478) DNA topoisomerase 1 [Ammonifex degensii KC4]
1
MKHLIIVESPAKARTLSKFLGSQFLVKASMGHVRDLPKSELGVDLENGFTPKYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWHLCHLLGIPPETPCRVEFHEITKNAVLNSLKSPRPIDLNRVNAQQARRVLDRLVGYGLSPLLWRKVKRGLSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLARLARFKGKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQEANRRLGMRLERTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIKEHYGAEFVGDVPPKERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLIWERFLAAHMAPAKYFLTRAEIEVGDYTFYATGRQLLFPGFLRLWRPEEEEEEGKLPPLREGEVLTFQEFVPQQHFTTPPPRYTEGTLVKALEEKGVGRPSTYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLKEHFPGIVDVGFTAAMEEKLDLVEEGQADWVDILREFYQSFSQDLVRADAAIEKVSLPDTFTDISCPRCGCPMVKKTGRYGEFLACSGYPECQMRMPVGTGVKCPRCGGELVKRRSKKGRYFYGCNRYPECNFVVWSEPVPEPCPECGSLMVRRGRGKKKRVICTNESCGYQRLEE
(982) Reverse gyrase [Ammonifex degensii KC4]
6
MELFLLAHGCPNCSGSVTDERLAAGLPCPQCLPQAGNNLSLAAVCCALRKENKIRELSPFCRAEEGLKEFELFFRQVTGLNLSPLQRLWAKRFFLEEPFAIIAPPGVGKTTFGLTVSLYNPQKSLILVPTRLLVWQVAEKLSHFAEKAGSKKKILSMTGKAKEKKELMQSEYDILVATTQFFYRHWSEIASHPITLVFIDDVDALLKSSRQVDSLFYFLGYSPEEVERALRSPEGEPREAGKRPQRLLILSSATLKPRTNRVRLFQRLMGFSVQRAVSTQRRVVDCYEEVPDFARALARAAELVRQLGPGGLVLVSPEEGREGVKEATAYLQAQGIEAESYLELTPEELVSRLAEGSLEVAVGLAHPTNPLVRGLDLPHVLKYVIFVGAPSHFFPLDLSPAPGALHGLGLALFPLFTPEEQRQVLRELRYLRPYLNLPADAVSRYPALEKRVQAFASFLKEKLKDPSFWEKIRAAEDLNLREEEGKLYLVLGDATTYLQASGRVSRLTAAGLTRGLAITLCTERRVLLSLKKRLRALTPAEIEFIPLQEVDLAGVMRGIEEDRRRIKAGELADKEGPRTALVVVESPHKARTIASFWGKPGIRRVKGVLAYEIPADERHLIITASLGHVFNLSRQQGFFGVLTFNHHFLPVFDTIKIYRETGEELVDPEEVARYPEGTVWDKQEILRGLQHLAFEVDEVYIASDPDAEGEKIAYDLYLSLRPFNPHIYRLEFHEVTPSAFRRALENPGQVNLYRVQAQLTRRVLDRWVGFCLSRRLWQKFGNRHLSAGRVQTPVLGWVVARAEEGRQRKARLTFSLGEATFTLEVPDRELGQKIFGELEKLSWEILEISEEERSPLPPFTTDTILTEAAHRLRLSAPVTMKLLQELFELGFITYHRTDSTRVSETGRFLVAKPFILQHYGEELFHPRSWGEGGAHEAIRPTRPMTEAELRWMVGAGLVDLSQERALELYGLIFRRFMASQMAPARVRKAKVRFRVPSYAWETEVVVEQIAPGFALLWPNFSVTELRPEARLTGKEYRELPLAEPYTEGTLVQEMKRQGIGRPSTYAEIVATLLNRGYLVVRGGRLYPTRLGFKVYRYLKENFPEYADTALTREIEAAMDLIAEGKEDYQEVLQKLYKVREILA
(546) DNA topoisomerase 1 [Halanaerobium hydrogeniformans]
1
MAKKNKNLVIVESPAKAKTIAKFLGRNYKVKASMGHVIDLPKSKMGIDIENNFEPNYITIRGKGKTLAKLRKEAKKSNEVYLATDPDREGEAISWHLSHALKLSEEDNNRIEFNEITKNAIKNAIKKPRQIDKNLVDAQQARRLLDRLVGYRLSPLLWKKVRKGLSAGRVQTIAVKLICEREEEIRNFEEEEYWTIDVDLKKDKDKLTASLYRIDNKKYNIDSEEAANKIVSDIKKEDFEIIKVKKRKRRRNPKSAFTTSTLQQTASSKLNYSAKKTMYLAQQLYEGMDIGSSGSVGLISYIRTDSTRLSEEAKAGAAKYIEAEFGDKFLRSKKKKKKKNKNSQDAHEAIRPTDTMRTPDKMKKHLSKDQYKLYDLIWRRFVASQMSPALYESISAQFKAGEKYKFRVSGSRLLFPGHLILTGKAKEDKIDLPVLKEGDVYKLQDVKPEQHFTKPPARFSEASLVKTLEEEGIGRPSTYAPTLSTIVSRDYVEKDGRYLKPTELGETVTELLSEYFPDVTDVEFTASLEQRLDEIEKGNEDWKKLLKDFYQPFYERLEHARENMERVQIVEETDEVCEVCGKPMVVKYGRYGKFLACSGYPDCKNTKPYLIKTGVDCPECDDGEVIERTSKKGRTFFGCSNYPECNFMAWNKPVEKPCPECGGVMVEKTTKAKGEHYKCINKECGHTEKAE
(1037) DNA topoisomerase 1 [Clostridium tetani E88]
1
MIMGQKLIIVESPAKAKTIGKYLDKTYHVEASMGHIRDLPKSQLGVDIDNNYEPKYITIRGKGELLTKIKKHAKKCDEIYLATDPDREGEAISWHLSQALKLEDNKKCRIVFNEITKSAVKNAIKEPREIDIDLVNAQQARRVLDRLVGYKISPILWRKVRWGLSAGRVQSVVLKMICDREKEIEEFIPKEYWTIECKLNKDRKDFLVKLISKDNKKIEINTEEESNNIIKELKQGQFTVDKIKKTNKNKNPLPPFITSTLQQDAYRKLNFSTKKTMSVAQQLYEGIDIKGHGTVGLITYMRTDSVRISKEAQNKARQFLENVYGKEYIPEKPRDYKGKKNIQDAHEAIRPTNIEITPKIALENLNSDQYKLYSLIWNRFMASQMAACVMEVNSVDVKNSEYIFRATGSIVKFDGFMIIYEYLNEDEKENINIPKLEKGELLKEKSIDSKQHFTQPPGRFSEASLVKVLEDNGIGRPSTYAPIISTLLERTYIERENRTLKSTELGVIVNNIMVEYFKPVVDAEFTAEMENKLDSIEEGNENWKNTVDEFYSPLKELIETAEKEVEKVTLEEKVTDVKCEKCGNNMVVKHGRFGDFLACPGYPECKNTKPIVHQLDVKCPKCHGEIVLKKSKKGRKFYGCSNYPKCDFVSWFEPVERKCDVCGNYMVKRYTKAKGDYIECSNKECKHKIMPEKKQE
(405) DNA topoisomerase 3 [Clostridium tetani E88]
2
MGKTLVLAEKPSVGREIARVLKCNKNSRSYIESNKYVVTWALGHLVTLADPEVYDNKYKKWEMETLPMLPKYMKLCVIGKTSKQFNEVKKLMNRNDIDEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAIIDGFNNLKPGKDYENLYKSAVCRSEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLALIVEREEEIKNFKPRDYYNIVAKTKGIQFNWQDKKGQMATFNEDFANNILAKVSGEIGNVTEVIEKDKKQYAPALYDLTELQRDANRIFGYSAKETLSIMQRLYENHKVLTYPRTDSRYISKDIVATIPQRLKSISIGIYSKFAEEILRGKIVAHKGFVDDSKVSDHHAIIPTEERVKLSNLSGDERKIYDLVIKRFLSVMLPPFEYIQTTIKVEVNGEVFIAKGKNIKHNGWKAVYNKEDLNEDNNDGDGLKEQVLPQIIKGDAIKFNLVNINKGQTKPPARFNEGTLLSAMENPQKYIKLNKEYAKTLGETGGLGTVATRADIIEKLYNSFYIEKKGKEIIPTSKGKQIIDLVPQDLKSPILTAEWEKKLELISKGKISGKEFINNMRNYSTKLVQDVKNSNEKYIHNNLTGTKCPNCEKYMLEVNGKRGKILVCQDRECGYRENISRFTNVRCPECHKKLELRGEGEGQIYVCSKCTFREKLSSFNKRFKEKGNNADKREVSRYMKKMKEQDKEPMNSALADALAKLNLK
(1761) DNA topoisomerase [Clostridium tetani E88]
3
MNLAKVIIAEKPSVAKNIADALNIKTRKDGYFEGKEYLITWAFGHLLQLYDAKDYNEIMKGWRLEKFPFIPMNFKYKIKQQNNNKNITDEGAEKQINIIKSLIERENVEAIISATDLDREGQIIGDELFSYLQIKKPIYRLLLNEWTPDEVKNGMKNLKCNEDMKFLRDAGISRQWSDWIIGINLTSVATLKYNIEDNKILNIGRVILPTLKIIYDRDKEIENFKATTYYKLLANFKTKKDKEFEGTYYEKNSEKFQDKSYLKIIEDLLKNKTYNIVDKHVEKKKEYAPYLFNLSNLQGYVTSKYKGWTSDKVLKVAQSLYEKKFITYPRTSSSVLDESLEGRAKKVLETLKKGLSYENQIRFNKSKRIFDSSKVESHSAITPTYIKPSKLTRDEEIVYIAIKNRFIMQFMPIAEFEETKITIKANDEDVKGEFLSKGKVQIVEGWRIVEKIETKDTILPLVEVKEKVDAVNSKIKTVTKKPPKHHTEKTLLRVMETCGKSFKDDENSEEMMNAILSGFSIGTAATRADTIKKLKDIGYIEAKGKSLICAPLGRTMIEIFPVKELLDLEYTGKLEKTLSDIEKGKFGKKEFMDLIYEFTNRAVELIKSDNSMLNKIKINLPEGVENLGKCPQCGNPVIEGSKGYGCSNWKNGCKFTIWKNDKYIQSFGKKVTKDMVKILLEKGRVGFRNLKSKKGNVFTAYFTYENNKEKGYYSWKMHFIN
(557) DNA topoisomerase III-like protein [Clostridium perfringens str. 13]
3
MKKVIIAEKPSVARNIADAFNIKKRKDGYFEGEEYLITWAFGHLLQLFDAKDYDENMKGWRMEKFPFIPEVFKYKIKQDSLNRNIIDKGAEKQIKIIKGLIDREDVDGIISATDFDREGQVIADEIFLYFSEKKPVYRLLLNEWTPDEVKKGMEKLKPNEEMQSLQDAGIGRQWADWIIGINLTSVTTIKYKLNDGQILNIGRVLLPTLKIIYDRDKEIENFKSSAYYKLNGTFKTSKNEEFEGTYYENNSEKFEDKKVLDEIKEKIKDKNAEIIEKQTERKKEYPPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKFITYPRTGSMALEESLVDRTRNVLEKLKVGLPYEEQIKFVQNKRVFDNSKVESHSAIVPTYMKPNNLTQDERIVYTAVKNRFLMQFMPVAEFEETKITSKINDKEVKGVFISKGKVQLIEGWRVVEKIDSKDTILPMVNEKEIVDLVDSKINKVTKKPPKKHTEKTLLRVMETCGKSFKEDAEEDSEEMMASILSGFSIGTPATRAETIKKLKDVGYITTKGKSLTCTELGRTIVEIFPVKELLDLEYTGRLEKTLSDIERGKVKKEDFLNLIKNFTIEGVKAIKNDDSMAKHFKVEAPEGVEVLGKCPNCGNPVIEGERGFGCVNWKNGCKYTIWKNDKYIASFGKQVTPQMVKLLLANGKVGFRNLKSKKGNTFAAYFIYEKDEEKGYFTWKMEFI
(1152) DNA topoisomerase [Clostridium perfringens str. 13]
3
MKKLVIAEKPSLAMNIVKALNSSESFERKDGYFESENYIISFAFGHLFKLYNIEEYTGEDKGAKWRNDILPFIPKEFKFSIKDDVGVKKQYKILEELIKSNRVDEIVACGDADREGEVIIRLIINNVFNNNSINKKVTRLWLPEQTTQSILYGLNNLKDIDTYNNLANEGFTRTFLDWLVGVNLTRYVTVKSKHLFPVGRVLVPIVQAIYERDKSIENFVPETYYQIESNEKTNDEIIKLVVKELAFTKSEFIKAKSFADELNTYEAIVISKDTKKVKKQPSKLFSLSKLQSLLSKKYKMTFKESLELIQKLYEKGFVTYPRTNTEYLAEAEKGKVKEIIDILCSEGYNLEFKDKKTIFDDSKIESHSAITPTVKIPKEDELKGKMLDVYNTIKNRFISNFLIEETLIDRTIIRIEVGDLEFSLKGDVIVQKGFLEYEPIKKDENTLPNLNVGDKINTNFKAIEKVTQAPGKMTTEMLSNYLKNPFKNYEIENEEEDYKAILDGLEIGTEATRTGIIENAKKYKYISENKSVLSIEPLGRKLIETLDKLNVNLSKEKTVEFSRILKKVYKNELNIDRAVDLISNELKSILEDSKNIEIEAIKEEKEVIGKCPRCGKNIYETSKSFSCEGYKDEPKCQFNIWKEDKFFKDKGKKVTKSIAKNLLAGKKVKMTGLKKKDGNGTYDAFVSLNDTGKYVNYKLDFSK
(735) DNA topoisomerase [Clostridium saccharolyticum WM1]
7
MKLVLAEKPSVAMSLSKVIGANQRGDGYMEGNGYIVSWCVGHLVELSQPEAYDEKYAKWRYDDLPILPEHWQYQVSTSTKKQFGILKKLMLRKDVKSLICATDAGREGELIFRLVYHQCGCKKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCRERADWIVGINATRLFSCLYGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKFRDFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTSLQREANRQLGFTAQQTLDYTQALYEKKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSFQIQPDVPAPVNAAQVINSKKVTDHHAIIPTKTAAGHDISSLPSGEQAILIMLAVRLICAVGTPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGRSSEDAEKNAEACNLPELSEGMTLELAGVDLKEGKTSPPKRFTEDLLLSAMESASSDEFPAGVERKGIGTPATRAAIIEKLVQKGFIERRGDKKTKYLCSTDKGNALVTVVPEQIQSPSMTADWEEKLLKIEHGEYDSDAFMGEISSMVNGLVKTYEAVKGADVLMQPERKVIGSCPACGSDVCETVKGWFCRDKSCKFALWKENRFFQTLGKQMTEELAKQLVNQGKARLTHCYSRKSNRYYDTTVRVETGEDGAAAFKLEFGGKK
(89) DNA topoisomerase 1 [Clostridium saccharolyticum WM1]
1
MANCLVIVESPAKVKTIKKFLGANYEVDASNGHVRDLPKSQMGIDVENDFDPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLMKALKLDELKDKQVYRISFNEITKNAVKASLKTPRVIDMDLVDAQQARRVLDRMVGYMISPLLWAKVKRGLSAGRVQSVALRLICDREEEIGAFIPEEYWNLEAVLKQEGSKKPLIAKFYGDKDGKIPIRNKEELEKILAGLEKQTYQVEEIKNGERIKKAPIPFTTSTLQQEASKVLNFSTQKTMRLAQQLYEGVEVAGRGTVGLITYLRTDSTRIAEEADAAAREYIGKQYGGQYVANGEQQKKSNAKIQDAHEAIRPTDISLTPVMVKESLQRDLFRLYQLIWKRFTASRMQPAVYETTSVRVGAGKYLFTLSASRLSFDGFMSVYVQEDDKEEANVLLGNLEKGSFLKLDKLESGQHFTQPPAHFTEASLVKAMEEQGIGRPSTYAPTITTIIARRYVAKENKNLYVTELGEVVNRMMKKSFPSIVDITFTANLEYLLDKVGDGSVQWKTVVKNFYPDLKEAVDKALVELETVTIADEVTDEICEVCGRNMVIKYGPHGKFLACPGFPECKNTKPYLEKIGVPCPKCGKEVVIKKTKKGRIYYGCEANPECDFMSWQKPSTKTCPKCGAYMVEKGSKLLCSNEQCGYSTDK
(410) DNA topoisomerase 3 [Clostridium saccharolyticum WM1]
2
MKSLIIAEKPSVARDIARVLHCTKNHDGVIEGEAYVVTWGLGHLVTLADPEDYDPKYKEWKMEDLPMMPDQFRLEVIKQTGKQYRVVKAQIHRSDVGEIIIATDAGREGELVARLILEKAGNKKPIKRLWISSVTDKAIKEGFAKIKNGHEYDNLYDAAMCRAEADWLVGINATRALTCKYNASLSCGRVQTPTLAIIARREEEIKNFVPKPYYGISAKCADPALSFTWRDEKSKSFRSFDRDRVEALFNHRKAIGEGVITEVKSVPKKTEPPQLYDLTELQREANRRFNYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDIVPSIKERLEACGVGPYRKLAGRLANQKIKTAPSFVNDKKVTDHHAIIPTEQFVQLDHMTIEERKIYDLVVRRFLAVLYPPFEYEQTEITLDLGGETLAARGKTVKAQGWKEVYENQDEEEEEQELKEQNLPVMKKGDMINGLTVTMTEGKTKPPAPFQESTLLSAMENPVSYMETKDKDMAKTLGETGGLGTVATRADIIEKLFSGFLLEKRGKDIFLTSKARQLLTLVPEDLKKPELTAEWEMKLSEIAGGKLKRAAFMKDIRQYSGELIRQIKTGEGSFHHDNLTSHKCPVCGKRMLAVKGKNNEMLVCQDRECGHREVVSRTSNARCPVCHKKLELKGKGDSQIFVCKCGYKEKLSSFKERRAKEGAGVSKRDVAKYMSEQKKEGNQPMNSAFADAFAKLNLGDNGK
(1620) DNA topoisomerase [Clostridium saccharolyticum WM1]
7
MSKSLYIAEKPSVAQEFANALKANGRRRDGYMESDQVIITWCVGHLVTMSYPESYDPKYKRWSLSTLPFLPREFKYEVIPGVEKQFKIVSSLLNRPDVDTIYVCTDSGREGEYIYRLVAQMAGVKDKKQKRVWIDSQTEDEILRGIREAKDESDYDNLSASAYLRAKEDYLMGINFSRLLTLRYGQHISNYLKSGKNTVISVGRVMTCVMGMVVRREREIREFVKTPFYRVIGTFSKEDPSNPGLSGLDFDGEWRSAPGSRYYESPFLYKENGFKERQYAEELINALSLMDPMEGTVVSIEKKKETKNPPLLYNLAELQNDCSRMFKISPDETLKLVQELYEKKLVTYPRTDARVLSTAVAKEIYKNIGGLKSFTPLSEAAAEVMEKGSYRTIEKTRYVNDKQITDHYAIIPTGQGLASIKGLSSLGIRVYEVIARRFLSIFYPPAVYQKYALELAAESVYPGSEPTLQHQMTNKEHFYANFRVMLDAGYLKVAEVSWGKKKQEEGNGGTPSEETVQEENNPESSQNQMNNPLFVAMLGSLKKGMKLSLKKLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLFHIKYLSLNSKTQVIVPTLLGEMIFDVVNASIRQLLNPELTASWEKGLNYVAEGTITPGEYMEKLENFVAGRTAGVLRLNNHYDLHGVFDAAAANYKKPK
(287) DNA topoisomerase 1 [Thermoanaerobacter sp. X514]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNSGKFEAKFYGTREDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYTNPEANYASKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFLASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVQEFYEDFYNTLKIAEEQMEEIDVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPNCDFILWDKPVDEKCPVCGSLLVEKNTKNGHILKCSNPECDYQKEVK
(1276) DNA topoisomerase 1 [Clostridium botulinum A str. ATCC 19397]
1
MGQKMGQNLVIVESPAKAKTIKKYLGKNYVVEASMGHVRDLPKSQLGVDIENNYDPKYITIRGKGELLDKLRKEAKKSSKVYLATDPDREGEAISWHLAHVLKIDESEECRIEFNEITKTSIKKAIKSPRRINENVVDAQQARRVLDRLVGYKISPILWSKIKWGLSAGRVQSVALRMICDREREIEEFIPKEYWTIECEVYKEKNKKPFIIKLTTKSGKKIEINNEEEAIEAIQDLKKGEFIVKKIKKTKKNKNPLAPFTTSTLQQDSYKKLNFSTKKTMSIAQQLYEGIDIKGFGAVGLITYMRTDSIRISEEAQKSTLEHIKSNFGEEYIPKTPRVFKGKKNIQDAHEAIRPTNIEITPTLAKESLTPQQYKLYELIWKRFVASQMASCILDSTSISIENGKYGLRASGSLIAFDGFMKVYEYSTEEEKDSIKIPELEDNEILGEKSINKSQHFTQPPARYSEASLVKTLEENGIGRPSTYAPIISTILDRKYVEREKKTLKPTELGDIVNNILSEYFKQIVDLEFTADMENKLDYIEEGKKSWREVVNDFFQPLIESIEIAEKEIAKITIEDKVTDVVCEKCGRNMVIKHGRYGDFLACPGYPDCKNTKPIVEEIDVKCPKCRDGKVLIKKSRKGRKFYGCSNYPDCDFVSWSEPVKEKCEECGSYMVKKQSKAKGEYYECANSECKHRKYLNNKE
(236) DNA topoisomerase [Clostridium botulinum A str. ATCC 19397]
3
MSKLLLAEKPSVARNIGEALGCKTRKNGYLEGNGYIVTWAFGHLLTLYDCKDYDHKLALWSFQNFPYIPTEFKYKVKNDGKNRNVVDAGAKKQLEIIKELINRGDVEEIISATDYDREGELIALLIFNYLKANKPIYRILINEWTPTEIKKGLKDLKKNEEMISLQDAGVSRQLADWVIGINFTSIATMKYTRGKGNLLNIGRVLMPTLKIIYDREIEIKNFKVEEFYELEATFKNKKGEYKGKFFYEKKEKFPNKKIMEKLKAEIKDKSGLVTEKTIEIKKENPPSLFNLSNLQGYITSKYKGFTADKVLKVAQSLYEKKHITYPRTESTALEESIKDKAKKVLEVLKNDLPFKDEIIFNTSKKVFNNAKVESHSAIMPTYIIPKNLTPDERLVYDAIKNRFISQFMKEAQYENTEIVTTVPGENYERLFKTKGKILKCKGWLKLYKEKKKDELLPPIEKDDEVEIKSLKIISKKTKPPAHHTEKTLLKAMETCGKNTKQSEDNEEESNILYGYSIGTAATRAETINKLKYAGYITPKGKSLLITDKGTKLIETFPIRELLDTDYTGKLEKKLYDMEKGKFKKEDFLKEIFNFTVNGVNKIKNIRSNVICDTRVKKDK
(195) DNA topoisomerase 3 [Clostridium botulinum A str. ATCC 19397]
2
MGKVLVLAEKPSVGRDLAKVLKCNKKGNGYLEGNKYIVTWALGHLITLSDPESYDEKYKKWSMDTLPMLPKRMKTTVIKKTSKHFSEVRKVMIRKDVEELVIATDAGREGELVARWIIDKVGFKKPIKRLWISSQTDKAILDGFRNLKPGKNYENLYHSAVCRSEADWIVGLNVTRALTCRYNAQLSAGRVQTPTLAMIVQREEEIKNFKPRDYYSIEGKTKGFTMHWESAKGRFNTFDEDLAKKVVSKVTGKEGKIIEVTESDKKKYAPALYDLTELQRDANRIFGYSAKQTLSIMQRLYENHKILTYPRTDSRYISKDVVGTLKDRLKAISISNYSKFTNEILKGNIKAHKGFVDDSKVSDHHAIIPTEEKPKLGNLSGEERNIYDLVIKRFLSVMLPPFEYIQTTIKSEVIGEKFVARGKVIKSKGWKAVYDREEFDDKNNNSDSDDIKDQTLPKVNKGDGIKFSNFKINKGQTKPPARFNEGTLLSAMENPQRYINLDKESSKTLGETGGLGTVATRADIIEKLYNTFYIEKRGKEIVPTSKGKQVIDLVPKDLKSPLLTAKWERELDSISKGNLRGQIFINKMRDYSTKLVEDVKNSKDKYVHDNLTGKKCPQCGKYMLEVKGKNGVINVCQDRECGYRENVSRFTNVRCPECHVKLELRGEGQGQIYVCTRCSFREKLSSFNKKYRNNQEKLNKRDVTKYMKKMQKENDEPINSALAEALSKLKL
(1331) DNA topoisomerase 1 [Acetohalobium arabaticum DSM 5501]
1
MAENLVIVESPAKAKTINKFLGKGFNVEASMGHVIDLPKSQLGINIEENFEPKYITIRGKGDVLKKLRKAVKKSDNVFLATDPDREGEAISWHLSRALKLDDESECRIEFNEITENAIQQAIEAPRSIDKDRVDAQQARRLLDRLVGYKLSPLLWKKVRRGLSAGRVQSVAVKIICQREEEIEEFEPDEYWSLEADLQTDSKQQFEAKLHRIDGDKFKLNNKEETDKVIVEAEKNNFVIEKIKERKRRNNPAPPLTTSSLQQRAASSLNFTAKKTMFIAQQLYEGLDLGSEGTVGLITYIRTDSTRISKEAQQDTRKFIEDNFGPRYRPKDTKKYKVKSGAQDAHEAIRPTSVFRTPKKVKSYLNNDQYRLYKLIWEKFVASQMTPAIYKTLSVDIKAGKYLFRSTGSRTLFKGYLAVDTFKNRKQDKDLPEDLEEGTEVELLEFKPEQHFTKPPARYTEAKLVKTLEKKGIGRPSTYAPTVAKIQDRGYVNKEGKRFVPTELGKTVNHLLNKHFPDVTDIKFTANLEQQLDDVEVGKEDWRELLKEFYFPFEERLNSAYENMEEVELEKEVTDEVCEKCGKNMIVKHGKYGKFLACPGFPDCKNTKPYLIKMGVDCIECEDGEVVQRKSKKGRTFYGCSNYPDCEFMIWYKPVQEYCPECGTFLMEKTTKKRGTEYLCADEDCDFKTTPEELESEE
(693) DNA topoisomerase [Moorella thermoacetica ATCC 39073]
7
MVNACDAGREGELIFRRIYAWCKGQKPVKRLWLSEATPAAIKEAFRHLRVGEELDNLAAAAEARAQADWLVGINTTRAFTCRHNRLLSVGRVQTPTLALVVAREREIRAFKPEPYFEVWATFRKSTGETYRGKWFREKQDRLQDKKKAGDLAKQISACGIVEKIEQKEVREQPPQLFNLNDLQKEANKKYGLTAQKTLDAAQALYEKHKLLTYPRTDSRHLTTALVRDTLAGRLEALTGIPAYAALVPENLPQLGKRYVDDSKVSDHHALIPTAVNPDLSKLSPVEQKVYDLVARRFLAIFYPDARYAVTRVVTTAGGESFLSQGRVELERGWKAVYGRQEEDGAESKDEESQTLPQLVEGEEVAVQGVEVKAKQTRPPQRYTEATLLAAMENAGRLVEDKEMADTLKTAGGIGTPATRAAIIERLIQVGYLRREKKNLLPTAKGETLIGLVPEEVKSVELTARWEEGLKEIEEGQRDCKEWLEGIKNFTTEVVRMAREQEAAPGADPDREVLGQCPICGREVMEYPKSYSCSGYKEGCRFAIWKEIAGKKVTASQAKELLQKGKTGVIKGFKSKTGKKFDAALTLGEGGKVNFEFAEGNRETLGKCPLCGKDVTESQKGYGCSGWKEGCKFVIWKEIAGKKITAGQAKELLQKGRTGVIKGFKSRAGKEFEAILVLKEDGKLEFEFEG
(1288) DNA topoisomerase 1 [Moorella thermoacetica ATCC 39073]
1
MLAKTLVIVESPAKAKTIGKFLGKNYTIKPSMGHVRDLPKSQFGVDVENNFEPRYITIRGKGEIVKELRAAAQKAQRVLLAPDPDREGEAIAWHLQHLLGLPDEAIRIEFNEITRNAIQEAVKKPRKIDQDRVDAQQARRILDRVVGYRLSPLLWRKVRKGLSAGRVQSVAVRLIVDREQEIEAFQPEEYWSLTAWLLPENEGEAFPARLVKYAGEDLNVKNEGEMESILHSLEGTTYVVAEVKQRERRKNPAAPFTTSTLQQEAYRKLNFTSRRTMQVAQQLYEGIDLGGGQGPVGLITYIRTDSTRVASVAQLEARDFLMERFGSEYVPEGLRQYKGRKDIQDAHEAIRPTSVWREPASLKNILTRDQFRLYNLIWERFVASQMQAAVMDTVTVDITAGPCLFRATGSVVKFPGFLKVYQEGRDGEDKDQEQRLPPLATGQTLKLQSLEPKQHFTQPPPRYTEATLVKTMEELGIGRPSTYAPTIETILQRGYVTREQKQFVPTELGRVVVALLKEHFPKIIDVEFTAHMEEQLDAIEAGKISWRQVLAEFYGPFEEVLEKAEAEIGTVEVPEEVSEEKCELCGRNLVVKMGRYGKFLACPGFPECRFTKPLLETIGVNCPECGGQIVARRTKRGRKFYGCQNYPRCTYVSWDKPTNQTCPRCGKRLVEKASRQGSRLVCPQKECGYVEEVRQAK
(748) DNA topoisomerase 3 [Clostridium cellulolyticum H10]
2
MGFTLILAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLIGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFTVQWQDSRNNQTRTFNKEEADGIVAKITGQMGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKPSVTKRFVDNSKVTDHHAIIPTEQFVDLFSLNSEERNIYDLIVKRFIAVLSKPFEYEQTTVKLDIAGESFYAKGKIVKSSGWKTVYDGFGKLDEDDEDDNDQSLPDIQKGHKAKVVGPKSINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERKGKEIYPTSKGTQLISLVPTDLKSPELTAKWEQQLTLISKGKVNSNVFVNDMKKYARKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHICPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGQQVDKREVAKFMRQQEKDENINSALADALAKWKNN
(1178) DNA topoisomerase 1 [Clostridium cellulolyticum H10]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAIKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVRKGLSAGRVQSVATKMICDREDEIEKFESQEYWSIIAKLVKPKASPNFGAKFYGIGKEKLELTNEEQVNSILEEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGYTTKRTMMVAQQLYEGIEIKGRGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPEKPREYKNKSASQDAHEAIRPTYIDLPHEQIKEYLSPEQYKLYRLIWDRFISSQMSSAIYDTVSADITAGKYLFKANGSKVKFPGFMVLYTEGNDNEGKDEAEQDEKENKLPQLNEGDILELKENTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAEMESELDSVEDGDKEWKAVMRDFYSSFAGVLKKAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNAKPIVEEAGVECPICKGKVLIKKTKKGRKYIGCEKNPECPFMSWDMPSPNKEVCSVCGSFMLQKFSGKKKVLKCSNDKCTSNIEASKDNTK
(261) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-mouse-Japan]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVSVEDDYEPNYINVRGKADLIKSLKKASKKSEKVFLATDPDREGEAISWHLAYILGIDVDDKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINSFEVKQYFTIEGSGKKNSKKYVFKLHSKHKEKLDELTENKVLEILDELSEGKYIVDEIKEGSKNKYPSPPFTTSTLQQEAYKKLNFQTKRTMSVAQSLYEGVEVKGYGVVGLITYMRTDSVRLSADSLNQANEFVAKVYGDKYKLDIPRQYGKNNKNIQDAHEAIRPTNVEITPDIAKQTLKDDQYKLYSLIWRRFLASQMRNAVYNTMAISIKNGDYLFKLNGSQLQFDGFLKVYEVDKDDKDLILPAFEEGEELKNVKVESIEHFTQPPPRYTEASFVKLLEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIEFTADMEKKLDGIEEGKASWKSIVHEFYKPLKEKIDIAENTVKKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSIIQKLNIPCPKCGGEINVRKSKKGKVFYGCSKYPECDFISWNEPSNVKCPKCGGITVKKIKRKQEFYECIDQDCKDK
(1023) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-rat-Yit]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVNIEDDYEPNYINVRGKADLIKSLKKYSKKSEKVFLATDPDREGEAISWHLAYILGIDLSEKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINNFEVKQYFTIEGTGRKNSKKYVFKLHSKNKEKLDELTKDRVSEILDDLSKGKYVVDEVKEGIKNKYPLPPFTTSTLQQDAYKKLNFQTKKTMSVAQSLYEGVDIKGYGVVGLITYMRTDSVRLSSDSLNQANEFVKKVYGDKYKLDKPRQYGKNNKNIQDAHEAIRPTNVEITPEIAKQTLKDDQYKLYSLIWKRFLASQMANAVYNTMSISIKNNGYLFKLSGSQLKFDGFLKVYEIDKDDKDLILPIFEEGEELNNIKIESVEHFTQPPSRYTEASFVKLMEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIDFTADMEKKLDGIEEGKVDWKNIVHEFYKPLKEKIDIAENTVEKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSITQKLNVSCPKCGGEINVRKSKKGKVFYGCNNYPECDFVSWNEPSDVKCSRCGGITVKKIKRKQEVYECIDENCKE
(657) DNA topoisomerase 1 [Bacillus atrophaeus 1942]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLNSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINEFKPEEYWTIDGSFLKGQETFEASFFGKGGKKLPLKSEADVKEILSQLKGNKYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAVEEAAAFIDQTYGKEFLGGKRKPAKKNENAQDAHEAIRPTSILRKPNELKTVLGRDQLRLYKLIWERFVASQMASAVLDTMSVDLENNGLTFRATGSKVKFSGFMKVYVEGKDDQLEEKDRMLPDLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVGLDNKRFVPTELGQIVLELIMEFFPEIINVEFTARMEQDLDNVEDGNTEWVQIIDRFYTDFEKRVKKAEAEMKEVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPKCEEGNIVERKSKKKRVFYGCDRYPQCDFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVECDYKEEPQK
(1155) DNA topoisomerase 3 [Bacillus atrophaeus 1942]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDRYIVTWALGHLVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKAQLTRKDVSGIVIATDAGREGELVARWIIEKAHVNKPIKRLWISSVTDKAIKDGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYFGIRAAVEGMTLTWQDKKTKQSRTFDQAVTSRLLDKLEGKSATIADLKKTAKKSFAPGLYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFISNDIVPTLKDRLEGMEVKPYALYVTKILKRGVKAHKGFVNDAKVSDHHAIIPTEEPLIPSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIADIGGETFTAKGKTVQSQGWKAVYDAYDEEDDQDEDRDQTLPALQKGDSLPVRALKETSGQTKPPARFNEGTLLSAMENPSAFMRGDEKNLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKDKDIFITSKGKQLLQLVPEDLKSPALTGEWEQKLSAIAAGKLKSSVFIKEMKAYANETVKDIKNSSQTFRHDNVTGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKKLELRGQGEGQIFACVCGHREKLSVFEKRKSKEKTGRASKRDVSSYLKQQNKDEPINNALAEQLKKLGLDK
(311) DNA topoisomerase 3 [Bacillus clausii KSM-K16]
2
MKKKAVLAEKPSVARDIARVLGCNQKGNGYLEGNGYIITWALGHLVTHADPEHYGKQYKTWKLEELPMLPKRLELVVIKQTAKQFHAVKHVLNRQDVGEVVIATDAGREGELVARWILEKAHVKKPVKRLWISSVTDKAIKDGFKQLKDGKRYETLYAAAAARAEADWYVGINGTRALTTKHNAQLSCGRVQTPTLAILADREEAIRKFVPKPYHTISVETKDGVTFRWADRRSKEERIFDDKRAKTLQEKLQQSAIVIDSVNAKTKRTPPPPLYDLTELQREANKRFGYSAKETLAALQRLYEQHKAVTYPRTDSRYLSSDLVETLKERLHAVDVQPFRKMVANAKKQGLANAKRQMVNDAKVSDHHALIPTEQPQSASAMSDKEAKLYHLIVRRFLANFFPPSESELTSVEATANGELLRAKGERLVSAGWRGQETGEEDEALARLLPAMSKGDKKAVKWVGMTQGKTSPPPRFNEGTLLAAMEKPAQHMEAKDETIKKTLAQAGGIGTVATRADIIEKLFSSFYIEKKGKDLYITSKGKQLLELVPAELKSPALTAEWEQRLEKIVQGKEQKQMFIAEMKEYAKAVVAQVKADTATFRHDNKTGEKCPECGKFLLEVNGKKGKMRVCQDRECGYRKNIAMTTNARCPKCKKKLELRGEGEGQVFACVCGHREKKAQFEQRRKQNKHKNVSKREVQSYMKKQNKQDQFANSALADQLAKLGLKGDDS
(1709) DNA topoisomerase 1 [Bacillus clausii KSM-K16]
1
MSDYLVIVESPAKAKTIGKYLGKKYVVKASMGHVRDLPKSQMGVSVEDNYEPRYITIRGKGPVLKELKTAAKKAKRVYLAADPDREGEAIAWHLAHSLNIDENSDCRVVFNEITKTAIKDAFKHPRPINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKLITDREKEIQQFVPEEYWSITGTFLLGDEPFEAKFYGRNGKKESLTSEENVNEVLKQIKGKQFAVADVVKKERRRNPVSPFTTSSLQQEAARKLNFRAKKTMLIAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKQETYEYIRSTYGEEYARKGERKQKQDKNAQDAHEAIRPTSVKYEPKQLKEYLSRDQLRLYRLIWERLVASEMAPAIMDTMTVDLENNGVKFRANGSKVKFPGFMKVYIEGNDDNKKEEDRLLPALAKGQQVEKTEVTPNQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVALDEKRFVPTELGEIVLDLIVEFFPEILDVEFTAKMEEDLDSIEDGRDNWISIIDQFYQSFEKRLKVAEEEMEEVEIKDEPAGEDCEKCGHEMVYKMGRYGKFMACSNFPECRNTKAIVKEIGVTCPTCKQGNIVERKSKKRRIFYGCDRYPDCEFVSWDKPISRPCPKCQGLLVEKKSKKGVFVACTSCDYEEEKQ
(1128) DNA topoisomerase [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
3
MTTVILAEKPSQARAYAVAFTQSQKGEGQIKVADPILPADTVITYGFGHLVEMALPEAYDASYKRWSLKKLPIFPDQYKYLVSRDKKKQFNIVANLLKRADTIVIATDSDREGENIAWSIMRQAGIDLKQKHLFRLWINSLEKAAIREGFQNLRPGWDYYYRYKEAQTRQISDWLVGMNGSPLFTLLLRKQGIKGTYSIGRVQTPTLYMVYKRDQEIANFKPEKYWLLMADFWQGRKKFTGRLLPETKFKSPAELEQFLLAKGGSLGKQTGRVAKVDKEQKSQASPRLFSLSSLQTEANRRYHASASQVLQAVQNLYENKFLSYPRTDCNYITDNEYAYLAQNLDRYQGLLPNSAEVKEQMKPLKAEKRYVDSGKVQEHHAIIMTKTVPSQAQMGKMSKLEGQVYGLVLRRTLEMFLKAYVYEKTTALINVGQLTFKASGNVSVNLGWKILEGPVKDAQLPSLEVGQELTAKLKEQEEETKPPAKFTEGSLITAMKTAGKTLDDEDAQATLKDVEGIGTEATRASTIEILKKRGYMQSRQNKLSVTPEGTILCKVAEAEPLLVSAQMTAQWEKALKQVGAKERSQDNFLGQIKKFISKMITEVPGKIQVDQGLQEEAQTRQAKTAAIGPCPVCKQGEITDKGKFYGCSNYRGGCHFTLPKKFAGKNMGKRIVKTLISKGKTDKLDGFISKKSGQRYSAKLQLEGDKLSLVFD
(1067) DNA topoisomerase 1 [Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365]
1
MPATAKEDKSKSSKKTTAAAKKSSPKRKKSKVKKDLVIVESPAKAHTIEKYLGRKYRVIASKGHIRDLPKSQMGVDIDHDYQPKYISIRGKGDTIKELKAEAKKANKVYLASDPDREGEAIAWHVAHVLGLDEKEANRVTFNEVTKDAVKDAFNHARTIDMDTVNAQQARRVLDRLVGYSLSPILWSKVKKGLSAGRVQSVALKLVIDREKEIKAFKPVEYWTIDAEFAKGKDKFQASFYGEEGKKTELPNNEAVQKLLAKFDKKQPFTVSKVVKREVRRQPAAPFTTSTMQQEANRRLNFRTSKTMNIAQHLYEGISLGKEGTVGLITYMRTDSKRISPVARQEAAQFIVEEYGSDFAVKKERHFKNQGDAQDAHEAVRPTSVYRTPKSLEKVLTKDELRLYTLIWSRFVASEMTPAVFDTVRYDLTQNGVTFRASGSVMKFAGYTKVYDNRSEKNVALPALEEGDEVKLTKSDNKQHFTQPPARYTEASLVRALEENGVGRPSTYAPTIQNIQSRNYVKLEGRAIVPTELGEIVDGLVEQFFPDITSVDYTAKLEDELDEVEEGKKDWVSVVDQYYKPFSKELEKADSEIQKIQIKDQPAGFDCEVCGAPMLVKMGRYGKFYGCSRFPDCRHTQTIVKKVGVTCPKCGEGEVLEKKSKRGRKFYGCSRYPDCDFVSWDKPISRVCPHDGHFLVEKKRKDGMVVLCPNGDYKEEPREEQGEAAE
(281) DNA topoisomerase [Streptococcus pasteurianus ATCC 43144]
3
MNAEVIVAPAVGHLVERINPYTNFENWEMANLPALPDGFAYEPKKDTAKRFKAIKQSVKEVDAIIIGTDPDREGEAIAYRILELIPGALRKIKYRLWANSLTKKGLEQAFSKLKNPKDSINYFHEADARGDADWLVGFNLSPFVTIKMKEEGYLDKKDHSMSVGRVQTPIVSLIVRNDEAIENFKPSPYWQLKLIDPEAKVTFGNDIKYQSKAEAELMLQQLANIAIVKTVTSEEKVQEAPKLYNLTNFQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFAYLVEHIDDYQMAIHKQLETPNRSPRKNYVNDKKVLEHYAIIPTENIPDLNELSDDEKLIYQKVVFRTLLMFAPDYRYQSTSVILDNHGLEFKASGTVTKDNGWRNYLAAKKEDKELPHYQEGKNLVVDCKLLEEMTKPPTRITEQILLKKLLPKYNLGTSATRDGMIDLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVNKIKWAITKQIEKGKQI
(1860) DNA topoisomerase 1 [Streptococcus salivarius 57.I]
1
MATATTTKTKTKTTKKTTAKKATKKRATPKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINELKKEAKKAKQVFLASDPDREGEAISWHLSHILGLEPDDKNRVVFNEITKDAVKNAFVEPRAIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGAFKKGAKKFQASFYGLDGKKLKLNNNDDVQAVLSRITSDDFNVDKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGINLGSGAQGLITYMRTDSTRISPVAQNQAAEFITERFGSKYSKHGSKVKNSSGAQDAHEAIRPSNVFQTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVTLSQNGVIFTANGSQIKFDGYMAVYNDSDKNKMLPDMAEGDTVKKVVTTPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVKLVAKRFEPTELGEIVNSLIVEFFPDIVDVKFTAEMEGKLDKVEIGKEQWQKVIDEFFKPFQKELEKAEEGIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVTCPTCGKGQVIERKTKRNRVFYGCDRYPDCEFTSWDIPVGRNCPKSGDYLVEKKVRGGGKQVICSNEECDYKESIVK
(1537) DNA topoisomerase 1 [Streptococcus pneumoniae TIGR4]
1
MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTVDAVFKKGTKQFHASFYGVDGKKMKLTSNNEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQKGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMVVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWRRVIDAFYKPFSKEVAKAEEEMEKIQIKDEPAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQVVCSKGDYEEEKMALCQL
(915) DNA topoisomerase 1 [Lactococcus garvieae ATCC 49156]
1
MAKASEKQTTKKKKTSSKKTASKKKTKIVKGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIDNDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAIAWHLAHILGLPLEDKNRVVFNEITKDAVKNAFKEPRSIDVDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPQEYWSIDGEFKKGAKKFKAAFWGVDGKKRALNNNDDVMEVMSRLSGPDFDVDKVEKKERRRNSPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGLTLGAQGHQGLITYMRTDSTRISPVAQGVAADFITDRFGAKYSKHSSKVSNKAGAQDAHEAIRPTNVLNTPEAIAKYLDKDQLKLYTLIWNRFVASQMTAAIFDTMKVNLSQNGVIFIANGSQVKFDGYLAIYNDSEKNNMLPDIAAGDVVKKANLKPEQHFTQPPARYSEATLIKVLEENGVGRPSTYAPTLETIQKRYYARLVAKRFEPTELGEIVNKLVVEFFPNIVNTEFTAEMEKDLDKVEEGQRRWVDVVDQFYKPFAVELEKAEVEMEKIVIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAIVKEIGVTCPSCHKGQIIERKTKKNRLFYGCDRYPECEFTSWDKPVGRSCPKCEHYLVEKKVRGGGKQVVCSNETCDYKEEKQK
(916) DNA topoisomerase 1 [Lactococcus garvieae ATCC 49156]
1
MAKASEKQTTKKKKTSSKKTASKKKTKIVKGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIDNDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAIAWHLAHILGLPLEDKNRVVFNEITKDAVKNAFKEPRSIDVDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPQEYWSIDGEFKKGAKKFKAAFWGVDGKKRALNNNDDVMEVMSRLSGPDFDVDKVEKKERRRNSPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGLTLGAQGHQGLITYMRTDSTRISPVAQGVAADFITDRFGAKYSKHSSKVSNKAGAQDAHEAIRPTNVLNTPEAIAKYLDKDQLKLYTLIWNRFVASQMTAAIFDTMKVNLSQNGVIFIANGSQVKFDGYLAIYNDSEKNNMLPDIAAGDVVKKANLKPEQHFTQPPARYSEATLIKVLEENGVGRPSTYAPTLETIQKRYYARLVAKRFEPTELGEIVNKLVVEFFPNIVNTEFTAEMEKDLDKVEEGQRRWVDVVDQFYKPFAVELEKAEVEMEKIVIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAIVKEIGVTCPSCHKGQIIERKTKKNRLFYGCDRYPECEFTSWDKPVGRSCPKCEHYLVEKKVRGGGKQVVCSNETCDYKEEKQK
(917) DNA topoisomerase 1 [Lactococcus garvieae ATCC 49156]
1
MAKASEKQTTKKKKTSSKKTASKKKTKIVKGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIDNDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAIAWHLAHILGLPLEDKNRVVFNEITKDAVKNAFKEPRSIDVDLVDAQQARRILDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPQEYWSIDGEFKKGAKKFKAAFWGVDGKKRALNNNDDVMEVMSRLSGPDFDVDKVEKKERRRNSPLPYTTSSMQQDAANKINFRTRKTMMVAQQLYEGLTLGAQGHQGLITYMRTDSTRISPVAQGVAADFITDRFGAKYSKHSSKVSNKAGAQDAHEAIRPTNVLNTPEAIAKYLDKDQLKLYTLIWNRFVASQMTAAIFDTMKVNLSQNGVIFIANGSQVKFDGYLAIYNDSEKNNMLPDIAAGDVVKKANLKPEQHFTQPPARYSEATLIKVLEENGVGRPSTYAPTLETIQKRYYARLVAKRFEPTELGEIVNKLVVEFFPNIVNTEFTAEMEKDLDKVEEGQRRWVDVVDQFYKPFAVELEKAEVEMEKIVIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECHNTKAIVKEIGVTCPSCHKGQIIERKTKKNRLFYGCDRYPECEFTSWDKPVGRSCPKCEHYLVEKKVRGGGKQVVCSNETCDYKEEKQK
(347) DNA topoisomerase 1 [Lactobacillus buchneri NRRL B-30929]
1
MATSTKTKPKAKAKSKTKRKSPKKNLVIVESPAKAKTIEKYLGRSYKVVASKGHVRDLPKSKMGVDIDHDYEPHYISIRGKGDTIKELRSAAKKAKKVYLAADPDREGESIAWHLQHILDLDPNEDNRVVFNEITKDAVKESFKHPRNIDMNLVDAQQARRILDRLVGYSISPLLWQKVKKGLSAGRVQSIALWLIIQREKAIKDFTPEEYWSIDSEFKKGRSKFKAAFYGLNGKKKELPNNEAVQKVLQQLDPKGDFDITKVTRRERKRQPQPPFTTSTMQQEANRKLNFRTRKTMMAAQQLYEGINIGKEGSQGLITYMRTDSTRISVIAKHEASQFLHEKYGAEYAATKPIKGKLPEGAQDAHEAIRPTSVFRTPASLKQYLTRDQFRLYQMVWSRFVASQMTPAIMDTMAVTIEQNNVTFKANGSKMKFDGFLKVYGDSKEKDNLLPDLESSDVVKLVKNNPDQHFTQPPARYSEATLIKALEEKGVGRPSTYSPTIDTIQRRYYVKEVGRRFEPTELGEIVNKIIVEYFPDVVNIDFTANLEGKLDQVEEGKENWIKLVDTFYKPFSDEVDAATKNMEKVQIKDEPAGINCEICGAPMVIKMGRYGKFYACSRFPDCRNTKAIVKEIGVICPKCHKGQVIERKSRKNRIFYGCSRYPDCDFVSWDKPIGRDCPKDGHFLVEKRVKGGTQVVCPNGDYEEPAQK
(273) DNA topoisomerase 1 [Lactobacillus helveticus DPC 4571]
1
MPTKAKSKSKTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDNYKPKYISIRGKGDTIKELKSEAKKAKEVYLASDPDREGEAIAWHIAHALNLDENAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWTIDAEFAKDKEKFKSAFYGVDGKKKELPNIDAVKDVLAKIDKKKNFTVEKVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRTSPVAQQEASKFLHENYGAEFAAKNQRHFKNQEDAQDAHEAIRPTSVYRTPESLKDVLTKEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVIFRTTGSKMKFAGFTKVYDNQQEKNVELPDLQEGDQVKMTKSDNKQHFTLPPARYTEASLVHALEKNGVGRPSTYVPTIDTIQRRYYVKLDGRSIVPTELGEIVDTLVEEFFPDIANVDYTAHLENELDEVEDGKKQWVNVVDEYYQPFKKELNKADSEIQKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKIGVVCPKCGKGEVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKHSKKGPVTLCPNGDYREEPQENEDK
(1107) Uncharacterized protein [Lactobacillus reuteri SD2112]
1
MATKTTKSTAKKTTRRRSKIKKNLVIVESPSKAKTIGKFLGRSYKVVASLGHIRDLPKKPDGGRY
(1379) DNA topoisomerase 1 [Lactobacillus amylovorus GRL 1112]
1
MPTKAKSKPKTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFDDNYKPKYISIRGKGDTIKELKSEAKKAKEVYLASDPDREGEAIAWHVAHALNLDENAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKEFKPKEYWSIDADFKKGKDSFKSAFYGVDSKKKELPNIDAVKEVLAKIDKKKDFEVAKVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRISPVAQQEASKFLHEKYGAEYAAKSQRHFKNQEDAQDAHEAIRPTSVYRTPESLKSVLTTEQYRLYKLIWSRFVASEMKPAVYDTVRADIVQNGVMFRTTGSKMKFAGFTQVYDNQQEKNVDLPDLEEGDKVQMTKSDNKQHFTQPPARYTEASLVHALEENGVGRPSTYAPTIDTIQRRYYVKLEGRSIVPTELGEIVDTLIEQFFPDIANVDYTAHLEDELDEVEDGKKQWVNVVDEYYQPFKKELDKADSEIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKEIGVVCPKCGKGQVVEKKSRRNRKFYGCSRYPDCDFVSWDKPIGRNCPNDGHFLVEKRSKKGPVILCPNGDYREDPQEDEIDK
(214) DNA topoisomerase [Lactobacillus salivarius UCC118]
7
MKKLILAEKPSVARDIGRILNANEKKKNYLEGKNYIITWALGHLLGLKMPEDLNKKWEKWQLETLPMLPKFIGIKPLPKTRGQLKTIESLVKRKDINEIVIATDAGREGELVARWILQYVHANKKVTRLWISSQTDKAVKQGFKELKPAEKYDNLYESALARATADWLVGLNVTRALTVKYQDNLSAGRVQTPTLALVRRQEEKIEKFMPQKYYRIALRIGKQTAYMKQKNIYAIKERDEAEKKKRHLDNFKGQIKDINSKIKREPAPLLYDLTELQREANKRYGYSAKKTLSLVQSLYEIHKVVSYPRTDSRYLSNDIKATLMERLQAIRKYDSRAEEAIKNKAKVILKKVFNDSKVTDHHALIPTEQVPNYSKFSADEQKIYNLIVSRFLGIFAQPYTVEELRVVVTFDKDEFIFVGKKVLDYGWKNKDAAEEVVLNLKKDTAVSPNFTVEEKLTTPPAPLTEAGLLAQMEKFGLGTPATRAEIIEKLVKSELMERTGHALRVTPKGKQLLNLVNKELVSPKLTAKWEKQLEDIAHGKMKSQKFIGDIKNDTKRLVSEVKNSKEDYKDFSLTKKRCPECNSFLKVRKTRDGEIYVCSNPECNYRRRKDAKVSNHRCPQCHRKMLIVEGKNGKYFRCKYDGTTEKMTVGKKSKKMTKHEERRLLKKINQDDEPQESPLALALKAAMGKNE
(1686) DNA topoisomerase 1 [Lactobacillus salivarius UCC118]
1
MPTTQKPKKKTTKRTRKKNLVIVESPSKAKTIEKYLGSNYKVMASLGHIRDLPKSKMGIDVENGYEPHYISIRGKGDVIKELRKEAKKASHVYLAADPDREGEAIAWHLSYLLGLNPEDKNRVVFNEITKDAVKNAFKSPRSIDMNLVDAQQARRVLDRLVGYSISPLLWSKIKKGLSAGRVQSIALNLIIQREKEIRDFKPEEYWTIDAKFKKGRTKFEADFWGVDNKKKKLSNEKDVKEVIEKIDKDKPFNVINIEQKERKRMPPLPFTTSAMQQTANNNLKFRTQKTMMVAQQLYEGINIGRGGAVGLITYMRTDSTRISSVAKHEAAVFLHENYGEEYAASKPRQGKLSENAQDAHEAIRPSSVERTPEKMAKYLDKDQLKLYTLIWSRFVASQMTPAVFDTMRVDIEQNGVQYRANGSKMKFPGFIKVYKAATSKDNLLPELKVGDEVDMVQNQPNQHFTLPPARYSEATLIRTLEENGVGRPSTYAPTLSTIQKRYYVKLVSRKFEPTELGEIVNSMIEECFPDILNVDFTAHLEDQLDDVEEGKEEWVRIIDEFYQPFSKEVDNAQVKMDKIKIKDEPAGIDCEICGAPMVIKLGRYGKFYACSRFPDCRNTKAIVKEIGVVCPKCHKGQIIERKSKKNRVFYGCSLYPDCDFVSWDKPIGRDCPKCSHYLVEKKTKKGMQVKCSNCDYEEAIQNN
(129) DNA topoisomerase 1 [Caldicellulosiruptor lactoaceticus 6A]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEVLKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVSCPKCSKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGGLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(810) Reverse gyrase [Caldicellulosiruptor lactoaceticus 6A]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEQCLSQEQISKNIFESLKKKGTLKDYQIYWNFQQNFDTFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEAFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFENLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILSELFNDLKNLIEN
(132) DNA topoisomerase 1 [Thermosediminibacter oceani DSM 16646]
1
MAKSLIIVESPAKAKTISRFLGKEYRVAASMGHVRDLPKSKLGIDIEKGFVPKYITIRGKGSIIENLRKEAAKAQKVLLATDPDREGEAISWHLAHLLDIPPETPCRVEFHEITKTAVSESLRHPRKINMNLVDAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSAAVRMICDREKEIAEFVPEEYWTIEAELADRPDGSSFKAKLHSRGNEKINLKNREQVEKIVADLQDQVFVVMEIKRGERRRNPAPPFTTSTMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGTVGLVTYIRTDSTRISEQAQKEAKEYIKANYGSEYVAESMSVKKAKKNIQDAHEGIRPTSVFRHPDSIKDSLTLDQYKLYKLIWERFLASQMAPAVYDTVSIDIKAGSYIFKASGSTLKFTGFMAVYIEGADEETEKDEGTLPILEQGQKLTLLKIMPEQHFTQPPPRFTEAMLVKALEEKGIGRPSTYAPIIDTIQKRGYVKKEKGRFKPTELGQLVTEILKEYFSDIVDLDFTAEMENQLDKIEAGEENWQKIIESFYRPFEEKLKIAEEKIEEVKIEDEVTEEKCELCGRNMVIKHGRYGKFMACSGFPECKNTKPLLEETGVKCPVCEGVIVVRKSKKGRKFYGCSNYPNCEFVTWDPPSETPCPRCGGLMVVKSTKSGKITACTNTECGYKDQVEG
(1657) DNA topoisomerase 1 [Pediococcus claussenii ATCC BAA-344]
1
MPTAKKNLVIVESPSKAKTIEKYLGRSYKVIASLGHIRDLPKSKMGVDIDNNYDPHYISIRGKGDTIKKLRTEAKKAKKVYLASDPDREGEAIAWHLSYLLGLDPKDKNRVVFNEITKDAVKNAFKTPRSIDTSLVDAQQARRILDRLVGYSISPLLWQKVKKGLSAGRVQSIALSLIIKREQEIRDFKPEEYWSIDSEFKKGRSKFNASFYGTGGKKKALKNEKAVQKILKLINPKDDFDVTSVKRKERKRFPSPAFTTSSLQQEANKTLNFRTRKTMMAAQQLYEGINIGKEGTVGLITYMRTDSTRISDIAKHEASVLIHEKYGAEYAAIKPRKGKMPEGAQDAHEAIRPSSVNRTPEDLKEYLSKDQYRLYNLIWSRFMASQMTPEVSDTMAVTIEQNDVQYRANGSKTKFEGFTKVYKTNKEKDNSLPAMEEGDKVKLVSNNPNQHFTQPPARYSEANLVKALEENGVGRPSTYAPTLDTIQKRYYVKLESRRFEPTELGEIVNDIIYEFFPDIVNIDFTAHLETELDEIEEGKEDWVKVVDGYYKPFSKEVDTAQEQIEKVQIKDELAGFDCEVCGSPMVVKMGKYGKFFACSRFPDCRNTQAIVKEIGVTCPKCGIGQIIERKSKRGRLFYGCSRYPDCDFVSWDKPVGRKCPVCHSFLVEKKIKGGKQVVCPNGDYEETPQK
(1042) DNA topoisomerase [Pediococcus claussenii ATCC BAA-344]
7
MKKKLIITEKPSVATDLARVLGVEQKNKTYYEGNNYIITWAYGHLLTLKLPEDINKDWQNWDLNDLPIIPKNIGIKPLPKTKQQLKAISRLAKRTDVESAIIATDSGREGEAVARYILEWIRFNKPVERLWISSQTTKAIREGFSNLRPAEQFDDLYASALARGKADWLVGLNVTRALTTKYKDNLSAGRVQTPTLSFIWKQEQEINSFRPHKFYKIYLVYQGQTADLLLKNSEQFETREQAEKVVQGLQKKSGLVEDLKVKQNMQDAPLPYDLTELQRTANSMYAFSAKKTLSIVQSLYEVHKIVSYPRTDSKYLSTDIKDTLKERLSALSGFDSQAKAYLRRGAKIVQRSVFNDQKVTDHYALIPTEESVQPAKLSSDELRIFRLIEKRFLGLFAEKFITETTNTTIGFGSAKFVFKQTRVVKPGWRFDLETETKKTKVQLKLKQQIEGQFIIKEKLTTPPKPLTEGTLLGKMEKFGLGTPATRAEIIEKLTQSELVKRTNGALITTPKGQQLLKLVNKSLASPDLTSKWEKSLESIAHGKVNYMDFVKDVEKETRRLVSEIKTSEIEYRDFGVTNKLCPECGYALKERNSRDGKILTCSHCGYRRRKDPKVSNHRCPQCHKKMVILEKNGQSYFRCLNDGTTEKMLDKKERKKKISKKEERKLLSKINNEDPEESPLAIAMKKAMEK
(1197) DNA topoisomerase [Carnobacterium sp. 17-4]
1
MEKVKKGLSAGRVQSVALKLICEREDEINRFEPEEYWSIGANFKKDKKKFKANFYGLKGKKQALSNAEDVQKIIKELDGDQFEVMSVTKKERLRNPALPFKTSSLQQEAARKLNFRTRKTMMVAQQLYEGISLGRGGAVGLITYMRTDSTRIALSAKNEAAEYIIKEFGPEYAASKPRIGKKAEGDQDAHEGIRPSSVLRTPKEVEKYLTKDQYKLYNLIWSRLVASQMTPAVFDTMKVDIAQKDVYFRANGSKVKFPGYQKVYIEGNDEGKEEKDNLLPEMEKGDKVKSIDIEPKQHFTQPPARFSESTLIRVLEDNGVGRPSTYAPTLETIQRRYYVKLQNKRFEVTELGGIVNGLINEFFPQIVDVHFTADMEKNLDEVEEGNKEWEKVIDQFYQPFAVEVEKAEENMEKVQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKPIVKEIGVACPVCGEGHVIERKSKKNRIFYGCDRYPTCEFVSWDKPVGRSCPKCEHYLVEKKAKGSKQVICSNCDYKEEVQK
(1700) DNA topoisomerase [Carnobacterium sp. 17-4]
7
MKTLIIAEKPSVGKEIARVLGATQKSKTHIEGKDVIVTWALGHLLGLKMPEDYKAEWATWDLNALPLIPEKMTTKPLTNTRGQLKAIKQLANRKDIGSAVIATDAGREGELVARWILEYVNFNKPVKRLWISSQTDKAIKDGFNQLQPSKKYDTLYDSAVARSEADWLIGLNVTRALTVKYQDNLSAGRVQTPTLAMVRKQEAKIQSFVPETFYTVQLTVDGKKAVLQEGAPRKFNDREKAEALVSSLKDKPITVVDIKEKQSVQQAPMPYDLTELQREANQRYQFSAKKTLSLMQTLYERHKVLSYPRTDSKYLTQDMVGTLKERVMAIQGFAPEEAKGILKRGAQVTQKGVFNTAKVTDHHGIIPTEERPRPEKMEADELKIYRMVVERFIGLFLPAYKVSKTTIVFSAADVLFSLQQETVLEKGWKKDVPKQSENVYKLNEQLMRTAYTIQKQLTEAPTRLSEGTLLQNMEKNGLGTPATRAEIIEKLISSELMERNQNKLSTTPKGQQLLTLVNPALVTPELTSKWEKSLEEISNGGLKKEDFLKNIKQETARLVTEIKTSTQTYKDHALTSKICPECGELLKERSGRDWKLLICSSSTCSYKRRKDPKVSNHRCAQCHRKMEIHEGKNGNYFKCKYCNITEKLEGKSSKKPSKHETKKLMQKINNQQEEVESPLALAMKAAMAKKE
(441) DNA topoisomerase [Carnobacterium sp. 17-4]
3
MDQSMGHTVILAEKPSQAQAYAESFGKFSKKDGYIVLNSSNDVITWGFGHLVELASPEEYKDEWKKWNMKELPIIPEIFKFKVGQGKAKQFNVVKKLLQEADQIIIATDSDREGENIARSIINQAKAGNKEIKRLWINSLESDEIQKGFSDLRDGREFYSSYIEAQTRQISDWLVGINLSRMYTLSLQKKGINEGVFSVGRVQTPTLYMIYTRQKQIENFIPEPFFELHATVKAENGLFKAKYSKKFSTKKELQELIQKHGLLASNPGMISSVETKRISQPSPFLFSLSDLQSLVNKKYKVSPSDTLKHVQSLYEAKLVSYPRSDCRYITDSEFRYLLERIEGYQGILNHTIKEPNTSKRKRYVDGSKVQEHYAIIPTKKVPTQKALEKLPSIQREIYFTILRRSMAMFETDYKYDETTVTVDIKTVPFISKGKVILDKGWQRLEYGASKKSNKETTSELPLVKKGELVEADLNTSEGFTSPPKTYTEGTLITAMKTCGKELENEEEKEILKATEGIGTEATRANVLETLKKQNYIEIQKNNVTVTQKGEILCQAVENTLLSSPEMTAKWETYLKKIKNEDGTQQAFLDSIQKFIAHTLDSSAQVIEKRDWSTHTNSINHLSQKTIGKCPVCGQMMIDKGKFYGCSGYSNGCTFTLPKRYVGKTLSEATLKKLLDTRETQLLKGFKKKTGQTFSAALILTEDNKLLFKPYEKTEKK
(839) DNA topoisomerase 1 [Enterococcus faecalis V583]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQEKWVEVVDRFYKPFEKELTNAEEKIEKIQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVTCPVCHEGQVIERKSKKNRIFYGCSRYPECDFTSWDKPVGRPCPKCGQYLVEKKVKGGKQVVCINGDYEENVQK
(1315) DNA topoisomerase [Enterococcus faecalis V583]
7
MVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILEYVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALTVKYQDNLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTISLSVESEKAKMTQKNPYALKERQEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAEQPLSTVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLGTPATRAEIIEKLIKSELMERTNSGLSVSAKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVCTNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMTKHEERRLMKKYSQPDEPEESALAQALKAAMNQE
(25) DNA topoisomerase III [Enterococcus faecalis V583]
7
MQLVIAEKPSVGMALSKVLGAKSRGDGYMEGGGWLVSWCIGHLVELAPADAYDPRYSKWNYADLPILPKPWQFQVLPDTKKQFEVLKTLIHRADVTALICATDAGREGELIFRLTYHLCGCTKPVKRLWISSMEEAAIQKGFDNLLDGKNYDNLYAAALCRAKADWLIGINGTRLFTTLYQGKSLNVGRVQTPTLALLAEREAAISGFQKEKFYTVELELEGFRAASERFASKTDAGRLRTGCVGKPATVQTVSQKEKTERPPKLYDLTTLQREANRLFDYTAQQTLDYLQALYEKRLATYPRTDSRYLTEDMAAGLPALCQSVAAALPFAADLSLPVNAAQVIDNSKVTDHHAILPTTEAAKTDLSALPSGEKNILFLVAARLLCAVGEPHTYAETAVTLECGGAVFSAKGKTETAAGWTAMEQAFHATLKKKPKQPEPSPPLPALTKGQKLTAGGASIKEGATSPPAHFTEDTLLSAMEHASAKEFAKLEDVEHKGLGTPATRAGVIEKLVRSGFVERKKKQLFPTEKGTELIKVMPDTLKSVKLTAEWEERLGAVERGELSPEDFMAGITAMLTELVKSYQGVTVASAALSASGRTVIGICPRCGKNVVEGKKSFFCEGWNAAPACDFALWKNDRFFTSKHKELTRKAAAALLKKGRVAMTGLFSEKKGVLYDAIVVMEDTGEKFVRFKLEFDNNTPKKKGN
(26) DNA topoisomerase III [Enterococcus faecalis V583]
7
MQLVIAEKPSVGMALSKVLGAKSRGDGYMEGGGWLVSWCIGHLVELAPADAYDPRYSKWNYADLPILPKPWQFQVLPDTKKQFEVLKTLIHRADVTALICATDAGREGELIFRLTYHLCGCTKPVKRLWISSMEEAAIQKGFDNLLDGKNYDNLYAAALCRAKADWLIGINGTRLFTTLYQGKSLNVGRVQTPTLALLAEREAAISGFQKEKFYTVELELEGFRAASERFASKTDAGRLRTGCVGKPATVQTVSQKEKTERPPKLYDLTTLQREANRLFDYTAQQTLDYLQALYEKRLATYPRTDSRYLTEDMAAGLPALCQSVAAALPFAADLSLPVNAAQVIDNSKVTDHHAILPTTEAAKTDLSALPSGEKNILFLVAARLLCAVGEPHTYAETAVTLECGGAVFSAKGKTETAAGWTAMEQAFHATLKKKPKQPEPSPPLPALTKGQKLTAGGASIKEGATSPPAHFTEDTLLSAMEHASAKEFAKLEDVEHKGLGTPATRAGVIEKLVRSGFVERKKKQLFPTEKGTELIKVMPDTLKSVKLTAEWEERLGAVERGELSPEDFMAGITAMLTELVKSYQGVTVASAALSASGRTVIGICPRCGKNVVEGKKSFFCEGWNAAPACDFALWKNDRFFTSKHKELTRKAAAALLKKGRVAMTGLFSEKKGVLYDAIVVMEDTGEKFVRFKLEFDNNTPKKKGN
(841) DNA topoisomerase 1 [Enterococcus faecalis V583]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQEKWVEVVDRFYKPFEKELTNAEEKIEKIQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVTCPVCHEGQVIERKSKKNRIFYGCSRYPECDFTSWDKPVGRPCPKCGQYLVEKKVKGGKQVVCINGDYEENVQK
(27) DNA topoisomerase III [Enterococcus faecalis V583]
7
MQLVIAEKPSVGMALSKVLGAKSRGDGYMEGGGWLVSWCIGHLVELAPADAYDPRYSKWNYADLPILPKPWQFQVLPDTKKQFEVLKTLIHRADVTALICATDAGREGELIFRLTYHLCGCTKPVKRLWISSMEEAAIQKGFDNLLDGKNYDNLYAAALCRAKADWLIGINGTRLFTTLYQGKSLNVGRVQTPTLALLAEREAAISGFQKEKFYTVELELEGFRAASERFASKTDAGRLRTGCVGKPATVQTVSQKEKTERPPKLYDLTTLQREANRLFDYTAQQTLDYLQALYEKRLATYPRTDSRYLTEDMAAGLPALCQSVAAALPFAADLSLPVNAAQVIDNSKVTDHHAILPTTEAAKTDLSALPSGEKNILFLVAARLLCAVGEPHTYAETAVTLECGGAVFSAKGKTETAAGWTAMEQAFHATLKKKPKQPEPSPPLPALTKGQKLTAGGASIKEGATSPPAHFTEDTLLSAMEHASAKEFAKLEDVEHKGLGTPATRAGVIEKLVRSGFVERKKKQLFPTEKGTELIKVMPDTLKSVKLTAEWEERLGAVERGELSPEDFMAGITAMLTELVKSYQGVTVASAALSASGRTVIGICPRCGKNVVEGKKSFFCEGWNAAPACDFALWKNDRFFTSKHKELTRKAAAALLKKGRVAMTGLFSEKKGVLYDAIVVMEDTGEKFVRFKLEFDNNTPKKKGN
(1317) DNA topoisomerase [Enterococcus faecalis V583]
7
MVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILEYVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALTVKYQDNLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTISLSVESEKAKMTQKNPYALKERQEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAEQPLSTVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLGTPATRAEIIEKLIKSELMERTNSGLSVSAKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVCTNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMTKHEERRLMKKYSQPDEPEESALAQALKAAMNQE
(840) DNA topoisomerase 1 [Enterococcus faecalis V583]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQEKWVEVVDRFYKPFEKELTNAEEKIEKIQIKDEPAGFDCELCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVTCPVCHEGQVIERKSKKNRIFYGCSRYPECDFTSWDKPVGRPCPKCGQYLVEKKVKGGKQVVCINGDYEENVQK
(1316) DNA topoisomerase [Enterococcus faecalis V583]
7
MVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILEYVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALTVKYQDNLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTISLSVESEKAKMTQKNPYALKERQEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAEQPLSTVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLGTPATRAEIIEKLIKSELMERTNSGLSVSAKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVCTNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMTKHEERRLMKKYSQPDEPEESALAQALKAAMNQE
(1550) DNA topoisomerase 1 [Enterococcus sp. 7L76]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENNYEPHYISIRGKGDVIKSLKAAAKKAEKVYLAADPDREGEAIAWHLAYLLGLDLKDKNRVVFNEITKEAVKAAFKEPRTINVDLVDAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDRENEIREFKPEEYWSIDGNFQKGRKKFKANFWGVDGKKKKLPNAEAVKEITSRIDGKDYDVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGIALGKQGTVGLITYMRTDSTRIADSAKAEAAEFIEKTYGDEFSAHGGRKAKNTQGAQDAHEAVRPSSVLRTPDEMKKYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLQQNGVTFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELVEGDVVKSVDIEPKQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLETIQRRYYVKLTNKRFEPTELGEIVNSLVSEFFPQIVDTHFTATMETDLDKVGEGQKNGLKLSIASTSPSKKN
(1313) DNA topoisomerase [Enterococcus sp. 7L76]
7
MSTVILAEKPSQALAYASALKQSTKKDGYFEIKDSLFTDETFITFGFGHLVELAEPGHYDEKWQNWKLESLPIFPDRYDFEVAKDKGKQFKIVAELLKKANTIIVATDSDREGENIAWSIIHKANAFSKDKTFKRLWINSLEKDVIRSGFQNLQPGMNYYPFYQEAQTRQIADWLIGMNASPLYTLNLQQKGVQGTFSLGRVQTPTLYLIFQRQEAIENFKKEPFFEVEASINVNQGSFKGVLSPTQRFKTQEELLAFVSSKQAKIGNQEGIIADVQTKEKKTNSPSLFSLSSLQSKVNQLYKATASQTLKAMQGLYEAKLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQVPTESALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDVQTLPLVIIGEHAEVDVKSAEKETQPPKAFTEGTLLTAMKTANKTVDDEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIKNKLVVTEKGKLLCQAVESQHLLTSAEMTAKWETYLKKIGKREGNQENFINNIKKFIVHLLEAVPTDIEKLSFADYQVQKEKEAEKSIVGKCPKCGNNIVLKKSFYGCSNYPECKFTLAEHFRKKKLTKTNVKELLEGKETLVKGIKNKEKKPYNAVVKIGEKGYIDFISFSK
(1719) DNA topoisomerase [Melissococcus plutonius DAT561]
7
MIKKQLIIAEKPSVAKDLSKVLGANQKNKGYFEGDTAIVTWALGHLLGLKMPEEINKEWQSWQMTTLPMLPKHLGIKPLPKTGQQLKTIKQLVNRKDIKEIVIATDAGREGELVARWILEYTHVTKPIKRLWISSQTDKAIKEGFKHLRPAKEYDHLYYSALARAKADWLVGLNVTRALTVKYQDSLSAGRVQTPTLALVRQQEKDISAFQAQTYFTISLQVADEKAKMVQKNPYSLKTRNEAELLVNKWNQQIGKVTDIKEKLKVESAPLPYDLTEIQKEANQRYQFSAKKTLSLVQSLYEVHKIVTYPRTDSKYLTTDMKETMNERLLAIREFDPIVKEYIKTGSQVKQTKVFQNAKVTDHHGLIPTEQRPNYTKLSNDEQKIYTMIVYRFLSLFAGPYKVAQTKITVTFGEQSFIFNQNKVESLGWRRETLEEKKKVSWKIGMTVSPKFSIQKELTSPPKPLTEGTLLAKMEKYSLGTPATRAEIIEKLIRSELMERTSQGIAVSPKGRQLLELVNPSLVTPELTEKWEKELEAIALGKQSSQNFLKEIETDTKKLVSEIKNSQKSYQDFSITQKKCPECQTNLKEKNTKEGKIYSCPNSECSYRRRKDPKLSNHRCPQCHKKMLIMDNQKNAYFKCKYCSITEKMLDKKNKKQKLTKQEERRLMKKYTKSETPQESALAQALKAAMSEKNPNH
(434) DNA topoisomerase 1 [Melissococcus plutonius DAT561]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLPKSKMGIDIENDYAPHYISIRGKGDVIKSLKTAAKKADKVYLAADPDREGEAIAWHLSYLLGLDPNEKNRVVFNEITKEAVKAAFKEPRTINLDLVNAQQARRILDRLVGYSISPILWRKVKKGLSAGRVQSVALKIIIDREKEIKEFIPEEYWTIDGNFQKGRKKFKASFWGIEGKKKKLPKADSVKEITDKLKDDKYQVTKVEKKERKRNPALPFTTSSLQQEAARKLNFRTRKTMMIAQQLYEGISLGKKQGTVGLITYMRTDSTRIAASAKVEATEYIEQTYGKEFSIQEERKVKKAQGTQDAHEAVRPSSVLRTPDSIKEYLNKDQLKLYTLIWSRFLASQMAPALLDTMKVTLEQNQVMFIANGSKIKFKGFMQVYIEGRDDGKEEKENILPELVEGDSVTSINIEPKQHFTQPPARFSEATLIHNLEENGVGRPSTYAPTLETIQKRYYVKLTNKRFEPTELGEIINTLIVDFFPQIVDVHFTAAMEEDLDKIGDGKEEWITVVDRFYQPFEKELTNAEEKIEKIQIKDEPAGFSCEECDHPMVIKLGKYGKFYACSNFPDCRNTKPIVKEIGVRCPICHEGQVIERKSKKNKLFYGCSRYPDCDFTSWDKPVGRLCPKCGKYLVEKKVKGGKQVVCINGDYEENVQK
(1759) DNA topoisomerase 1 [Tetragenococcus halophilus NBRC 12172]
1
MAYKYLVIVESPAKAKTIEKYLGRNYKVVASVGHVRDLPKSKMGIDVENNYEPYYITIRGKGDVIKDLKKHAKKAERVYLASDPDREGEAIAWHLSYILGLDPHDKNRVVFNEITKDAVKEAFKEPRTIDLDLIDAQQARRVLDRLVGYSISPILWRKVKKGLSAGRVQSVALKMIIDREKEIRNFTPEEYWSIDGNFKKGRKKFKANFWGLDGKKKKLPNEDAVKEVTQRISGKDYNVTKVEKKERKRNPAAPFTTSSMQQEAARKLNFRTGKTMMVAQQLYEGISLGKGGTTGLITYMRTDSKRISDTAKQEATDFIEQTYGKNYAAHSNKKLKNAQGAQDAHEAIRPTSAMRSPEEIGKYLDKDQLKLYRLIWSRLIASQMKPAILDTVKATLDQNGVIFVANGSKVKFKGFMEVYVEGRDDGKKDKENVLPELASGDIVQSEDITPNQHFTQPPARFSEATLIRTLEENGVGRPSTYAPTLQTIQKRYYVKLTQKRFEPTELGEIVDNLIEDFFPEIVDASFTAGMEEDLDHIEEGKEEWVKVIDRFYQPFEKELETAEEKMEKIEIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPECRNTKPIVKEIGVTCPKCQKGQVIERKSKKNRIFYGCDRYPDCDFISWNKPIGRNCPKCDHYLVEKKKKASKQVVCSNCDYKEDEQK
(585) DNA topoisomerase [Tetragenococcus halophilus NBRC 12172]
7
MKQLILAEKPSVAKDLGRVLGANKKTKNYYEGPNVIVTWALGHLLGLKMPEDINKNWQTWQMETLPMIPKNIGIKPLPKTGQQLKAIKQLAHRKDIKEFVIATDAGREGELVARWILEWVHFDKPVKRLWISSQTNKAIKEGFKQLKPAKEYDALYESALARSKADWLVGLNISRALTVKYEDSLSAGRVQTPTLSFVRQQEKQIDKFRPQTYYVIELEVAGQKAARIQKNPYEIKEQQEAQNLITQMSQHAGAVVSVNEKNKTENAPLPYDLTEIQREANQRYGFSAKKTLSVVQSLYETHKVVTYPRTDSKYLTNDMKKTMKERLQAIANFSPEVKDYIKSGAKVEQKAVFNDAKVSDHSGLIPTEQGANPAKFSNDEQKIYNMIVTRFLTLFAKAHKKLQQKATVKFGDETFVFTQNKIIEAGWKGQEESEKNVNKWQEGQKIQPNFSIKKELTKPPKPLNEASLLAKMEKFSLGTPATRAEIIDKLLRSELMERTPSGLQVSPKGKQLLDLVNPSLVTPDLTKKWEEELEAIAQNKFSSKKFLAQIEKDTKELVNEVKNSQKKYQDFSITQKKCPECRSFLREKNTRNGKIYVCSNSECSYHRRKDPKVSNHRCPQCHKKMEIIEGKNGAYFRCKFDGITEKIPNKKEQKKKMSKQEEKRLLKQYSKPDEPEESPLAIAMKEAMNKD
(1062) DNA topoisomerase [Tetragenococcus halophilus NBRC 12172]
7
MSTVILAEKPSQALAYASALKQSTKKDGYFEIKDPLFTDETFITFGFGHLVELAEPGHYDEKWQNWKLESLPILPDRYDFEVAKDKGKQFKIVAELLKKANTIIVATDSDREGENIAWSIIHKANAFSKDKTFKRLWINSLEKDVIRSGFQNLQPGMNYYPFYQEAQTRQIADWLIGMNASPLYTLNLQQKGVQDTFSLGRVQTPTLYLIFQRQEATENFKKEPFFEVEASIKVNQGSFKGVLSPTQHFKTQEELLAFVSSKQAKIGNQEGIIADVRTKEKKTNSPSLFSLSSLQSKVNQLYKATASQTLKAMQGLYEAKLLSYPRTDTPFITENEFAYLKANFGKYSGFLGLDLEMVQTEPRKRYVDGSKVQEHHAIIPTKQVPNESALAKMDDLQRKIYALVVKTTVAMFLPDYLYEETKIQTKVADLLFQSIGKTPKQEGWKILFKQQTKEEKEDVQTLPLVIIGERAEVDVKSVEKETQPPKAFTEGTLLTAMKTANKTVDNEEAIKILQEVEGIGTEATRASIIEALKQKEYIQVIKNKLVVTEKGKLLCQAVESQHLLTSAEMTAKWEIIESEQVIVRKDRLPAHFL
(1034) DNA topoisomerase 1 [Leuconostoc sp. C2]
1
MVEPGKVAKKPAAKKTTKRKKSKNQKKLVVVESPAKAKTIEKYLGSTYKVVASLGHIRDLPKSTLGVDVDNDYDPKYINIRGKGDLIKGLRKEAKAAKVVYLASDPDREGEAISWHLQHILGLDPDQPNRVVFNEITKDAIKNAFKTPRKINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIAREREIQAFEPEEYWSLDSEFQKSRQKFKATFYGFDAKKQVLPDNDSVQSVLKNIDQSADFDVMKVNAKERKRNPQPAFTTATMQQTANTQLNFRTRKTMMAAQQLYEGINLGRGIGQIGLITYMRTDSTRISSVARHAAAVYIHDTWGEEYSQHKLVQGKLPEGAQDAHEAIRPSDVTITPSSIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNGVIFRANGSKTKFQGFTKAYPAAKEKDNALPDLAEGDRVKLANINPEQHFTLPPARYSEAALIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVENSFPDVTNMKFTARVEHELDEIETGDKQWVPVIDSFFKPFSKELEIAETTLEKVVMHDELAGMDCDICGAPMLVKMGRYGKFHACSRFPDCRHTQTIVKEIGLICPKCGKGQIIERKTKRQRTFYGCSRYPDCDFVSWEKPTEKTLPDGTTPKDDEMSDGQQNSQQPTDNKEEAT
(1858) Topoisomerase IA [Leuconostoc sp. C2]
3
MPNYLILTEKPSAAANFVKALGGKTGTFNNFTYKITNLRGHVMTLKDPEEMVAEDLKKQYKSWLVKHLPWDLNDFSWERTYIRQRNMRTGKTESTKKIIDELKKEAKTGYDAIVIATDTDPSGEGELLAWEALDAIKWRGQVLRANFMDESATGVKTAMMNLRDVSDKQQDGEYIKGESRNRWDFASMQLTRIATTAAKKQGFKVVAREGRLKSVIVWQIYAQLLAIKNYVKKPYFEVKFKDPAGHIFGRVTPDGDVIPWRFSTKNDAQKDMTQYHESAVANEKHQTRTQAPGKLLDLAGLAAILAPRGFSAKEVLSTYQKMYEAQVVSYPRTEDKTVTPEQFNELLPKIDQIAQLVQVDTRLLTHRQPRPTHVKKQGAHGANRPGENIPTSLTSLTKFGPSAQAIYDILAKNYLAMLAEDYVYDHVTADLQDYPRFKTAFNIPIEMNFKAVYDSQRAVKVEDEVEDDNSGQLGPNAQPYLYEGANKKPQTPTTKWIMAFLEKHHVGTGATRVSTLSDMSRGTKSMIKETRGKLMLTETGNVSAVMVKDTWIASPKITKRLFEMMDQVGQFEITMPKLLDSITQVVEHDMPIMLSNADELELLLGKPKPALKRPVTEKITGVFKGEEITFAKSWSGHSFTDDELTKLLNGDEISFDAKSKRGKSYTAIGKMAKQTFKGRTFYGFKLNPK
(1396) DNA topoisomerase 1 [Erysipelothrix rhusiopathiae str. Fujisawa]
1
MKNLVIVESPSKSKTIEKYLGEDFEVVSSKGHIRDLATTGKGGLGVDFDNDFEATYKISKDKKDVVKELKAKAKKADAVYLATDPDREGEAISWHLANELGVDLDQDNRVVFNEITKDAVLSAFESPRHIDMNLVKSQETRRILDRIIGFKLSKLLQAKIKSKSAGRVQSVALKLIVDREKEIDAFTPEEYWSVLAFFENEGNIIETSAERFKGKKLKLTNEAEAQAVLDAAQGSFNITKLEKKKRKKESKLPFITSTLQQEASTRLGFPAKKTMRVAQKLYEGIQMGADTEGLITYMRTDSTRLSNVFVEDAKAFIVEEYGKEYLGKYRQGKKTENTQDAHEAIRPTSISRRPEEVKSYLTPDEYKLYRFIYYRTLASLMAPSISDSVSVVFSQNDYDFNGSGSIMTFDGYLKVYEYEKTTDKVMGELDETKAYNAQKIEKNQHFTQPPARYTEARLIKELEELGIGRPSTYSMILETIVYRAYATFGAVSETSKTKVFKPTDQGILTNEKLQEHFSDIINVHYTANMEDELDRIAEGEENNVEALQRFVDKFYPLLEEADEKMEKIEVEKVGEVCPDCGGELVYRFGRYGKFIACGNFPECRYNRALDQDKRPEPEKTGEVCPDCGEPLVKRKSRYGTFFVGCSGFPKCRYIQPNENAKKPKTKKPEEVSAEHEPLGEEIKD
(1270) DNA topoisomerase 1 [Leuconostoc mesenteroides subsp. mesenteroides J18]
1
MAETKTATKKKKAAPRKKSKIKKNLVIVESPSKAKTIEKYLGRNYKVVASLGHIRDLPKSTLGVDVENDYDPKYINIRGKGDVIKGLRKEAKAAKAVYLASDPDREGEAIAWHLQHILDLNPEQPNRVVFNEITKDTIKNSFKTPRVINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIAREREIQAFQPEEYWTLDSMFKKNRTKFKSIFYGFDGKKQPLPDNDSVQDVLKRINKDGDFDIVKVDTKQRKRQPQPPFTTSTMQQTANTQLKFRTRKTMMAAQQLYEGINLGKGLGQVGLITYMRTDSTRISSVAKNAAAQFIHDTWGEEYSQHKPVQGKLQEGAQDAHEAIRPSDVNRTPESIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNGVIFRANGSKTNFEGFTKAYPTAKKKDNVLPSLSEGDKVSLANTDPEQHFTLPPARYSEATLIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVEESFPDVTNMKFTAAVEHELDEVETGNKHWVPVIDSFFKPFQKEVEKAETSLEKIIMHDELAGMDCEVCGAPMLVKMGRYGKFYACARFPDCRNTKAIVQEIGLLCPKCHKGQIVQRKTKRGRTFYGCQRYPDCDFVTWDKPTEKTLADGTTPKDDEKKEPVKK
(1176) DNA topoisomerase 1 [Leuconostoc gasicomitatum LMG 18811]
1
MVETKNKTTKLVTKKTTKRKRAKVKKNLVIVESPSKAKTIEKYLGSSYKVVASLGHIRDLPKSTLGVDVENDYDPKYINIRGKGDVIKGLRKEAKAAKKVYLASDPDREGEAIAWHLQHILELNPEEPNRVVFNEITKDTIKNAFKIPRKINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIISRERKIQAFEPEEYWTLDSEFKKSRSKFKSSFYGFDGKKQPLPDNESVQYVLKQIDQSADFNIVKVEAKERKRNPQQPFTTSTMQQTANTQLNFRTRKTMMAAQQLYEGVNLGRGIGQIGLITYMRTDSTRISSLARNAAALYIHDTWGEAYSQHKPIQGKLPEGAQDAHEAVRPTDVTRTPESIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNNVVFRANGSKTKFQGFTKAYPAAKEKDNALPDLSVGDKVKLTNTNPEQHFTLPPARYSEAALIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVEESFPDITDTHFTASIEHELDEVEVGDKHWVPVIDSFYKPFSKEVEQAAATLEKVIMHDELAGMNCETCGAPMIVKMGRYGKFYACARFPDCRNTQTIIKEIGLLCPKCHKGQIVERKTKRQRTFYGCSRYPDCEFVSWDKPTEKTLADGTTPKVPEDEVSKA
(920) DNA topoisomerase I-like [Leuconostoc gasicomitatum LMG 18811]
3
MTNYLILTEKPSAAANFTKALGGKTGVFNDFTYKIANLRGHVMTLKDPEAMVAEELKKQYKSWLVKHLPWNLSDFSWARTYIRQRNMRTGKVESTKKLIDDLKKESKSGYDAIVIATDTDPSGEGELLAWEALDAIGWRGQVLRANFMDESVSGIQKAMHQLRDVSDKMADGEYVKGESRNRWDFASMQLTRIATTAAKKAGFKVVAREGRLKSVIIWRVYQQLDAIKNYVKTPYFEVKFKDPAEHVFGRVTPQGDVIPWRFATKEEAEIDFSQYHKTDVINEKHQTRTQAPGKLLDLAGLASILAPRGFSSKEVLSTYQKMYEAQIVSYPRTEDKTVTPEQFNELLPLIDQIADVVGVDKMLLTHRSPRTTHVKSQGAHGANRPGENLPKTTQSLVKFGASGPAIYEVLAKNYLAMLAEDYVYDHVTANLKDYPEFKTAFNRPLKMNFKLVYDSQKAIKVEEEEEENSTASQLGPQARPYLHEGANPKPQTPTTKWIMAFLEKHNVGTGATRVSTLSEMSRGIKAMLTETRGKLGLTETGQVSAIMVKDTWIASPKITKRLFEMMDQVGQFDMTMDQVLDSVTKVVEHDMPIMLDNAEQLETLLGKPKQVPKKKVTEKMTGLFKGEEITFAREWSGHIFTDDELTKMLNGAEISFQSKSKRGKIYTATGKLAKQTFKGSTFYGFKLNPKAKK
(592) Dna topoisomerase i (Omega-protein) [Leuconostoc kimchii IMSNU 11154]
3
MPNYLILTEKPSAAANFVKALGGKTGTFNNFTYKITNLRGHVMTLKDPEEMVAEDLKKQYKSWLVKHLPWDLNDFSWERTYIRQRNMRTGKTESTKKIIDELKKEAKTGYDAIVIATDTDPSGEGELLAWEALDAIKWRGQVLRANFMDESATGVKTAMMNLRDVSDKQQDGEYIKGESRNRWDFASMQLTRIATTAAKKQGFKVVAREGRLKSVIVWQIYAQLLAIKNYVKKPYFEVKFKDPAGHIFGRVTPDGDVIPWRFSTKNDAQKDMTQYHESAVANEKHQTRTQAPGKLLDLAGLAAILAPRGFSAKEVLSTYQKMYEAQVVSYPRTEDKTVTPEQFNELLPKIDQIAQLVQVDTRLLTHRQPRPTHVKKQGAHGANRPGENIPTSLTSLTKFGPSAQAIYDILAKNYLAMLAEDYVYDHVTADLQDYPRFKTAFNIPIEMNFKAVYDSQRAVKVEDEVEDDNSGQLGPNAQPYLYEGANKKPQTPTTKWIMAFLEKHHVGTGATRVSTLSDMSRGTKSMIKETRGKLMLTETGNVSAVMVKDTWIASPKITKRLFEMMDQVGQFEITMPKLLDSITQVVEHDMPIMLSNADELELLLGKPKPALKRPVTEKITGVFKGEEITFAKSWSGHSFTDDELTKLLNGDEISFDAKSKRGKSYTAIGKMAKQTFKGRTFYGFKLNPK
(529) DNA topoisomerase 1 [Leuconostoc kimchii IMSNU 11154]
1
MVEPGKVAKKPAAKKTTKRKKSKNQKKLVVVESPAKAKTIEKYLGSTYKVVASLGHIRDLPKSTLGVDVDNDYDPKYINIRGKGDLIKGLRKEAKAAKVVYLASDPDREGEAISWHLQHILGLDPDQPNRVVFNEITKDAIKNAFKTPRKINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIAREREIQAFEPEEYWSLDSEFQKSRQKFKATFYGFDAKKQVLPDNDSVQSVLKNIDQSADFDVMKVNAKERKRNPQPAFTTATMQQTANTQLNFRTRKTMMAAQQLYEGINLGRGIGQIGLITYMRTDSTRISSVARHAAAVYIHDTWGEEYSQHKLVQGKLPEGAQDAHEAIRPSDVTITPSSIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTIEQNGVIFRANGSKTKFQGFTKAYPAAKEKDNALPDLAEGDRVKLANINPEQHFTLPPARYSEAALIKALEENGVGRPSTYAPTLDTIQRRNYVRIDARKFVPTELGEIVQTIVENSFPDVTNMKFTARVEHELDEIETGDKQWVPVIDSFFKPFSKELEIAETTLEKVVMHDELAGMDCDICGAPMLVKMGRYGKFHACSRFPDCRHTQTIVKEIGLICPKCGKGQIIERKTKRQRTFYGCSRYPDCDFVSWEKPTEKTLPDGTTPKDDEMSDGQQNSQQPTDNKEEAT
(1032) DNA topoisomerase 1 [Peptoclostridium difficile 630]
1
MAKTLVIVESPAKAKTIEKFLGKSHYTVKASVGHVRDLPKSKLGVDIENNFEPQYINIRGKGDVIKELKKEAKKSKQVYLATDPDREGEAISWHLAHILNLDESEDCRIEFNEITKDAIKKAIKHPRNIDINLVDAQQARRVLDRLLGYQISPILWQKVRKGLSAGRVQSVTTKLICDREKEIKAFIPKEYWTIDVEAKTVKDKDITLKFYGKNDEKIELENEEAVNEILKEMEGKDLKVEKIESKSRRKSAPKPFTTSMLQQEGANKLFFTTKKTMMIAQELYEGIDIEGEGTVGLISYIRTDSKRISDEAKEKAKGYIVNNLGENYYKNTGDKKEKKDTKKVQDAHEAIRPTSVDRTPESIKASLSKDQYKLYNLIWRRFVASQMEDSVFDILNVECKIGDIVFKATGSKMKFDGYTKVYNFSEREDKILPSIEKGDILNIENILPDQHFTQPPARYTEASLVKTLEELGIGRPSTYAPTIATILNREYVEKQGTSLCPTELGIIVTDILENNFHKFIDVDFTADMESKLDVIEEGNTDWKKIVSESYAPLKEAIEEALENIEKVNMDEETDEICENCGSNMVIKYGRFGKFMACKNYPDCKTTRPIMNKIGVKCPKCEEGDIILRKSKRGKAFYGCSNYPNCDFVAWNKPTGEFCEKCGSYMVEKVTKSETKTVCSNKECNKETKEHNDGKE
(28) DNA topoisomerase [Peptoclostridium difficile 630]
7
MKLVIAEKPSVAISIAKVIGATKKKDGYYEGNGYKVSWCVGHLIQMANPESYDEKYAKWNMADLPIIPREYKYEIAKSTKKQFTILKKLMNDKEIDIVINACDAGREGEAIFRLVYNQANCKKKMKRLWISSMEDSAIKEGFDNLKDGSFYDNLFESAQARAIADWLVGMNLSRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEIANFKKEKYFTVELDLDGFSLSTDRIDDKTVTEQLINLLGNSIEITDVIQKEKITKPELPFDLTTLQRECNKYFNYSAKQTLDYTQSLYEKKLITYPRTDSRYLTEDMITSTINNIVGKHDFDTGRIKMVFNSKRVTDHHAIIPTASSMNEDLASLPESELKVYELVLNKLHASVGYPLIENTTKIVAVFDGFEFTSSGKVIVDEGFTKYLKKYIKKKNEDTVFPDLKIGDSLDIKEKEIKENYTSPAKHFTEDTLLKDMELAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVSDTFKSAGTTAKWEMELSDIAQGKASKENFLKAIENEIKELVSTYSK
(573) DNA topoisomerase [Peptoclostridium difficile 630]
7
MILVIAEKPSVAQTIAAVLGVKEKKDGFLTGSGYIVSWCVGHLVGLAEAAAYGEQYKKWNYDSLPILPQEWKYTVAADKEKQFKTLKELMHRADVSEVVNACDAGREGELIFRFVYEMAGCKKPMRRLWISSMEDSAIKEGFSRLKNGKEYDALFASALCRAKADWLIGINATRLFSVLYNHTLNVGRVQTPTLKMLVDRDAAITTFKKEKYYHVRLALSGAEAASERISNKAEADTLKTTCEASKAVCTSLLKEKKTAAPPKLFDLTSLQREANCLFGYTAKQTLDLAQALYEKRLLTYPRTDSSYLTDDMGDTAAGIIKLLCGKFPFMAGKDFTPELAKVLNSKKVSDHHAIIPTMELAKTDLAALPESERNILTIAGARLIMATAAPHTFEAVTAVFECAGQSFTARGKTVLSDGWKEIDRKYRAILKSKPETDDADSDTEKTLPPFTEGQNFDNPAAKVTEHDTTPPKPHNEASLLSAMERAGSEDTDPDAERKGLGTPATRAAVIEKLVKGGFVERKGKQLLPTKDGINLVCVLPDTLTSPQLTAEWENNLTQIAKGKADPAAFMKGIEDMARELVKTYPFLSEADKGRFKEEKPELGKCPRCGSPVYEGKKNYYCSNKECSFTMWKNDRFFEERKVTFTPKIAAALLKSGKVNVKKLYSPKTGKTYDGTIALADTGEKYVNYRIELSKKK
(1711) DNA topoisomerase [Peptoclostridium difficile 630]
7
MKLVIAEKPSVAISIAKVIGVNKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYAKWNMADLPIIPSAYKYEVAKATKKQFNILKKLMNDKEIDTVINACDAGREGESIFRLVYNEAKCKKKMKRLWISSMEDSAIKEGFDNLKDGKGYDNLFESAQARAIADWLVGMNISRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVELSMNGFTLSTDRIDDEVAAEQLINLVGDKIEITDVIQKEKITNPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYPRTDSRCLTEDMITSTINNILGKNDFDTGRIKTVFNSKKVTDHHAIIPTISSLKEDVSKLPLSEAKVYFLISDKFHASVGYPLIENTTKIVASFDGFEFTSSGKVIKDEGFSKYLKEYKSKKNEDAVLPNVSVGDVLSIENKEIKEKFTKPPKHFTEDTLLKSMEIAGNDALEKGVEVERKGLGTPATRAGIIENLIYKGFVERDKKNLIATHKGISLVTIVADNFKSAETTAKWEMELSDIAQGKSSKKEFLDAIENEIKEAVLTYRK
(918) DNA topoisomerase [Peptoclostridium difficile 630]
3
MKLVLAEKPSVAKTIASFLGAKTRQDGYFEGNDYIITYAVGHLVSLYDMKDYDKDKYSGSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVINATDNDREGELIAFLIFLLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAAGYTRLITDWLIGINFTSVATLKYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYYEIEGHFKAEAGEYKGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAPKLFSLTSLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASKASQTLDKLKVGLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPKSLSKDEQLVYDAIKDRFVANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKNDLLPLVNKDDVVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDTTVLSGYSIGTSATRADVLKKISQVGYVKKKGKSYSITELGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGKYTRKEYLTNIISFIYQNVNIIKQDASKNINTEAYTFDSKTKKFTKTKEKKQKKDVTNTEKEVAISKDSNNKKEVKNGDENQSLGKCPICQGDVLEFDKGFACKNHKECKFVIWKNDKYLSLYKKKVNKTMVKNILKKGETKVKSLTAKNGNKFDATLKYDKNPDTGYFNWKIEFDN
(1879) DNA topoisomerase 3 [Peptoclostridium difficile 630]
2
MGKILVLAEKPSVGRDIAKVLGSKNEKNGYIEGPKYVITWALGHLVTLADPESYGERYKSWSLEDLPILPKHLKTVVIKKSGKQFNTVKSQMNRNDIDEIVIATDAGREGELVARWIIEKSQVKKPIKRLWISSSTDKAIKDGFAKLKSGKEYENLYYSAIARAEADWIIGINATRALTTKYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLELIATKGNSDIKFIWNDKNNNSSTFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPALYDLTELQRDANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIKAVNISDYSKICNRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVFMSDFSDKERKIYNLVVKRFLAVLSPPFEYEQTTISATVEGEIFKAKGNKVINLGWKESYKDIEDEDEYESIPNVLEKDVLKVKGLKITSGKTNPPPYLNEGTLLTAMEKNGLGTVATRADIIEKLFNSFLMEKKNKDIYITSKGRQLLDLVPVDLKTPELTASWEKKLLDISKGKLSKNTFINDMKDYSKDIVLEVKNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLICEDRECNTRKTISQVTNSRCPNCHKKLELRGEGEGRIFTCSCGYREKLSSFNKRKQEEKQKASKKDVNQYLKNQNKNQETFNNPFAEALAKLKNK
(1084) DNA topoisomerase 1 [Thermoanaerobacterium xylanolyticum LX-11]
1
MEKSLVIVESPSKAKTIHKYLGKNYKVEASMGHIRDLPKSQLGIDIEKNFEPKYITIRGKGPIIEKLKKEAKNASKIYLATDPDREGEAISWHLASLLNIDINEKCRIEFHEITKNAIQNAIKNPREINMNLVDAQQARRILDRLVGYNISPLLWKKIKRGLSAGRVQSVATRLICDREKEIEDFKPEEYWSISAYLYKEKKTQSFEAKFYGTKDGKVELKNENDVNEIVKDLTDDYVVENVKIGTKKRNPSPPFITSTMQQEASKTLGFTAKKTMMIAQQLYEGVEIKGEGSLGLITYMRTDSTRVSDEAKKAAYEYILQKYGKEYANPNATYAKKGGNIQDAHEAIRPTYIDLDPEKIKDSLKPDQYKLYKLIWSRFLASQMSPALYDTMNVDIINKNYVFKASGSKIKFSGFMAVYTDDDENENEDKMLPMLNSGDFLKLKELKPEQHFTQPPARYTEATLIKELEEKGIGRPSTYAPIISTLLERGYVIKEKKNLKPTELGFIVTDVMKEFFPDIVDVKFTAQMEEQLDRIEEGIEKWCDVIDEFYNGFNASLKIAEEQMKDIEIKDEETDIKCEFCGRNMVIKYGRYGKFLACPGFPECKNTKPLYEEIGVTCPKCGGKIIIKKSKKGKVYYACENSSNCGTMFWDRPISETCPKCGALLVEKHSKGRKIIKCSNCDYVK
(292) DNA topoisomerase 3 [Coprococcus catus GD/7]
2
MKTLVIAEKPSVGRDIARVLQCTRNSQGALEGEKYIVTWALGHLVTLADPEGYDAKYKSWRGEDLPMMPQHFKLVVIKQTHRQFQIVKNQLLRKDVGTIVIATDAGREGELVARWILKIAGNKKPVKRLWISSVTDKAIREGFKNLKDGRAYLNLYAAAEARAEADWLVGMNGTRALTCRYNAQLSCGRVQTPTLALIASREQEIKSFVPKKYYTLTTVSHGMTWNWQDGKSGSNRSFDRGRIQSIAEKAEKDEMVITDVQRTVKKSYSPGLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYIGKDVAETLKERLQACAVGPYRKVAGKLLLQPIRMDKRFVDDSKVSDHHAIIPTEQFVQLDHMSSEERKIYDLVVRRFLAVLYPPCEYEQIKLTGSCAGEKWTAGSRMMKEAGWQQAYESEWEEEDDDSLMTVTSMPKLEKGRKDTVMRPKVSEGQTKPPAYYNEGTLLTAMEKGNLGTVATRADIIDKLFNSFLMEKKDKDIRVTSKGRQLLGLVPEDLKKPELTADWEKKLLAISEGRLKKDVFISEIRGYTEEIVKEIAGGEGQFRHENLTNHLCPNCGKRMLSVQGKNSKMLVCQDRSCGYRESIARKTNARCPKCHKKMEMYGKGDAQTFVCTCGYKEKLSAFQNRRKKEGAGVSKRDVQQYMKRQQKEANEPINNAFAAAFAKLNLETKEGE
(1278) DNA topoisomerase [Coprococcus catus GD/7]
7
MYLVIAEKPSVSKAIAEVIGAQEREDGYLQGTDCMVSWCFGHLAEYVSPDAYDEKFNQWRYEDLPIIPKDWKVTVSEDKKDQFYILKRLLNSPEIEYVVNACDAGREGELIFKHVYDLSGSKKPVKRLWISSLEDSAILDGMQHLRSAEEYRHLAEAAVCRSQADWLVGMNATRAYTTKYFKKLTVGRVQTPTLAMLVERAGQISNFQKEKYFNVELDCDGIPAVKPKIFDPDEAEQLRSRCQGSEAIVTAVKETEKKVKAPKLYDLTTLQREANRIYGMTAKQTLDTAQSLYEKKLITYPRTDSQYLTEDMEQTARNVVRQIYEKYQLTGPFDQPEQPDVKKVMNNSKVTDHHAIIPTMELASCHLDELKSWEEKILFLIAVHTVMAMSKDHIYQETEIEVECQEEIFKAKGKIVLQDGWKLFENCFKNKDRMAIVDPDQEMKERMPKVTQGQTFYAVDAEKTEHFTSPPKPYSEDTLLAAMETAGNKEFDEDTEKKGLGTPATRAGIIEKLVYSQYATRKGKQIIPTDDGKVLVEILPDFLKSASMTAEWENQLLLMEHGEIAPEQFMTGIKNMLTMMLNGCDAISEEETRRFQTRESIGTCPVCGSLVYESKTNFYCSNHDCHFALWKDNRYLQSMEKNMDKKMAAELLKSGCVHVKDLYSRKKNMYFEADLHMDADETGRVKFSLSFPKKKPKNKSKKK
(1772) DNA topoisomerase 3 [Clostridium lentocellum DSM 5427]
2
MGKILVFAEKPSVGKDIARVLKCTQKQNGFFEGPKYVVTWAMGHLVGLSDPEAYGNQYKTWSMETLPMLPERMKLTVLKGTGKQFQIVKSLMLRKDIDEIIIATDAGREGELVARWTIDKVGVKKPIKRLWISSVTDKAISEGFKNLKPGKDYENLYKAAVCRAEGDWLVGLNVTRALTCKFNAQLSAGRVQSATLAMIVAREEAIKNFQPKPYFTLSAKCKGIQLAYKGKKGDRFFDEKQIVTLIGKLEGSKAQVTEYKETSKKQYAPALYDLTELQRDANKRFGFSPKETLSVMQRLYENYKVLTYPRTDSRFLSEDIVPTLKERINAIAIGPYKVGAREVLKNGIKSSKHFVDNSKVSDHHAIIPTEESPDLSKLNSDERKIYDLVVKRFLSVLLPPMAYNEGVLEVSSEGECFVAKGKKVIEPGWKMLYEIEADEDEDEVVQSLPEVKKGETVVLEQFFKTKQMTKAPSRFTEATLLSAMEKPHQYVEVDQKAAKTLGETGGIGTVATRADIIEKLYNMFYIEKSGKEIVPTSKGKQLIELVPVDLKSPLLTAEWEMALEQISKGKQDPKAFMKKIRVYSEELVQSVKGSGEKYIHDNLTGKRCPECNKLMLEVKGKHGKLYVCQDRNCGYRENISRFTQTRCPNCHKKLELRGEGEGQIYVCTTCTFREKLSVFNKKYRSESKKVDKKSVQKYLKEQTKKEEGNFAFAEAFAKLNK
(1795) DNA topoisomerase [Clostridium lentocellum DSM 5427]
3
MKKVIIAEKPSVAKNIADAFDIKTKRDGYYEGEDYLITWAFGHLLQLYDAKDYDESMKSWRLEKFPFIPEEFKYKVKSDGKNKAIEDVGARKQLNIIKDLIDREDVESVISATDFDREGQVIGDEIFLYFNEKKPIYRILLNEWTPEEVKKGISQLRPNEEMKSLQDAGIGRQWADWMIGINLTSVATVKYNSGSKKILNIGRVLLPTLKIIYDRDKEIEQFEASTYYKLLANFKTSQDEVFEGTYYEKDEEGKDNEKFDNKATLESMVELIKNKPAQIVEKQVEKKKEYAPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKYITYPRTGSLALEESLKGRTKKVLDTLKIGLPYEGQICFADHKRIFDNSKVESHSAIVPTYIIPKSLTPDEQVVYNAVKNRFLMQFLPIAEFEETKLITKIIDVPEESLKGVFISKGKVQLVEGWRIVEKFEAKGTKEGKENKDTLLPQVTQDELVEMKNANVAEVTRKPPKAHTEKTLLRVMETCGKSFKGDEKEEGKEESEEDTLKMMASILSGFSIGTPATRAETIKKLKDAEYIRAKGKSLVCTDLGKALVETFPAKQLLDLEYTGRLEKTLSDIEKGKFQKDEFLSMIKAFTEEAVEAIKNDTRVLSGTKVEVPKNMEPVGVCPVCGNAVVENEKAFGCVNWKSGCKYTIWKNDKYITMLGKNVTRQMVELLLKNGKVGFRNLKGRNGNTYAAYLKYVKNDQTGYFNWEQEFI
(440) DNA topoisomerase 1 [Clostridium lentocellum DSM 5427]
1
MADNLVIVESAAKVNTISRFLGKNYKVEASIGHVRDLPKSQLGVDTANNYEPKYITIRGKGELLQKLRKDVKNAKCVYLATDPDREGEAISWHLYHALKLQEKKVCRITFNEITEQAVKEAIKHPRDINTDLVDAQQARRVLDRLVGYEISPILWKKVRKGLSAGRVQSVTLRLISDRDKQIREFVEEEYWSITANLQQGKGKTFEAKLDTYKNEKCDINNEEEAKKIVKACKKGHFQVVSSKKGTRVKNTVLPFTTSTLQQEAAKHLGFSTQKTMNIAQQLYEGIKVGKKEVGVVTYIRTDSIRIADKAKEEATTYITQKYGEQYLGAKKQIEKAKKAHIQDAHEAIRPTYMEYEPNEIKEYLSRDQFRLYQLIWNRFVASQMAPAQYETYSIKVQNGDYEFKASYSIELFDGFIKVYNLGEEKAKKEAKFQVEEGEQLVCGSIIPNQHFTQPPAHFSEATLVKTLEENGVGRPSTYAPTITTLLARGYIVKESKILYMTELGEVVNQIMKEYFDEVVDVDFTANMERILDEIASGNVEWKEIIKSFYPHFHHTVEYAESQIENIDLTEHTDIPCEKCGTHMVVRYGKYGKFLGCPNFPECNGTKPWYEETGISCPECNGKILMKKTKKGRSYYGCEHNGEGCEFMSWDKPTGEKCPICGEALIEKGNSKNKKIVCRNSKCNYGKQNKN
(906) DNA topoisomerase 1 [Coprococcus sp. ART55/1]
1
MIRITGNLQKGQIAMAKNLVIVESPAKAKTIKKFLGSNYEVIASNGHVRDLPKSQMGIDVDNDFEPKYITIRGKGDILAALRKAVKKADKIYLATDPDREGEAISYHLMKALKLENKDYKRITFNEITKNAVKNSIKQARDIDMNLVDAQQARRVLDRLVGYKISPVLWAKIKRGLSAGRVQSVALKLVCDREKEINDFIPQEYWTLDANLTGGKLKKPITFKFTGDGKNKEEISGRAALDEILSGLQDGEYVVKSIKESERNKKAPLPFTTSTLQQEASSKLNFATSKTMRIAQQLYEGVDIKGRGTIGLITYLRTDSTRISEEAVAAADKYITDNFGEIYIGDSNGRAKTDKKIQDAHEAIRPTDVTLSPVMVKEQLSRDQFRLYQLIYNRFLASQMAGAVYSVKSVKVSCGDATFQTSASKIAFDGFLAVYNLDNDRGETVAGINNLAEGDVLELDGFEEKQHFTQPPARYTEALLVKTLEELGIGRPSTYAPTISTILARRYITKEQKKLYVTAIGDAVNQSMEQAFPVIIDVNFTANMESLLDKIGEGTVDWKVVVRNFYPDLDEAVKKAEAELESIKIEDEVSEEVCDVCGRNMVIKYGPHGKFLACPGFPECRFTKPFYEKIGVTCPKCGGDVVIKTTRKGRRYYGCINAPECDFMSWAMPSNEKCPECGKYMIVKGNKLVCSDQECGYTCNNKAAETADK
(460) DNA topoisomerase III, bacteria and conjugative plasmid [Coprococcus sp. ART55/1]
7
MQLVIAEKPSVAKSIADVLGALDRQDGYFEGGGYLVSWCVGHLIELAEPESYGEQWKKWTYESLPVNPEHWQYEIKEDTKEQYDVLYGLLHDSRVDEVVCATDAGREGELIFRLVYNMASCKKPMKRLWISSMEESAIREGVENLKPGSDYDHLYHSALCRQEADWLVGINGTRLFTVLYGGKVLKVGRVQTPTLAMLVEREAKIMNFKKEQYFMAHILCGGVDAVTERIDNKTEAENVAGACRNGQALVTSVEKEEKTVSPPKLYDLTTLQRDANRLFGFTAKQTLEYTQSLYEKKMCTYPRTDSQYLSDDMEQTAGNVIEAIFSSILFEENRMFNPDIKRVLNSKKVTDHHAIIPTMEIAKADLAALPETERKILSLVANRLLCATGEKHLYETVKAELSCGGYTFTTSGKSVLKNGWKDFEDAFKRSFKATEEKEQEDKKLPELSEGQTFDGVQTKISEHYTTPPKHFTEDSLLSAMERAGNEDMSDDVERKGLGTPATRADIIEKLVKDGFVKREKKQMLPTEDGMKLITVLPDVVKSSKLTADWENALTLVAKGEMEREDFMADIETMESDLIHTYHEVSDEQKKMFAQEQKVLGKCPNCGGEVVKGKYGAFCKNKCGMNVSRIMGVALSDEQVESLLAGKKTLLKGITSKAGKKYDAYIIPSGTEEYHYTKDGEEKSGAQFKFVMEFPNKKFTGKKK
(285) DNA topoisomerase 3 [Ruminococcus sp. SR1/5]
2
MKSLVIAEKPSVARDIARVLHCSQKGNGTLEGKAYVVTWALGHLVTLADPEEYDKKYTKWELSTLPMMPEKMKLVVIRQTSKQYNAVKTQLYRKDIGEIIIATDAGREGELVARWILAKADCHKPIKRLWISSVTDKAIRDGFAHLKNGHDYDDLYRAAQARAEADWLVGMNGTRALTCKYNAQLSCGRVQTPTLAMIARREQEIREFKPEDYYGIILQAGNVRWTWRDGKSGSLRTFKKERAQEIQTKAGKSSLTITKVSRKPKKTYAPGLYDLTTLQREANQKYGFSAKETLNIMQRLYENHKVLTYPRTDSRYIGKDVVPTIKERLQACGTGPYRKLAGALVNKPIQTSAGFVDDKKVSDHHAIIPTEQFVQLDHMTNEERKIYDMVVRRFLSVLYPPAVYELVSMEGTAAGETFAASGRIVKSAGWREVYEGGWQDEDEEESGDKLKDQKLPELTEGQILTVEGAALTAGKTKPPARFTEATLLGAMENPVHFMESHDKKAAKTLGETGGLGTVATRADIIEKLFNSFMMEKRGNEIYITSKAKQLLELVPEELKKPELTADWEMKLSDIANGKLRQDKFLTGIRKYACEIVDEIKGGQGTFRHDNMTNKKCPNCGKHLLAVNGKNAKMLVCEDRECGYRETVSRTTNARCPKCHKRMEMLLKGKEETFVCQCGYKEKLSSFQARRAKEGAGVNKRDVQRYLKKQQKEANEPVNNAFAQALSGIKLD
(1434) DNA topoisomerase 1 [Acetobacterium woodii DSM 1030]
1
MIKTLVIVESPAKAKTIKKYLPKGFEVEATMGHVIDLPKSRIGINIENNFAPEYIKIRGKAALLKSLKSAAKKADQVYLATDPDREGEAISWHMANFLEIDLTTKCRIEFHEVTKKAVNAAIENKREIDIDLVNSQQARRILDRLVGYSLSPFLWKKVKKGLSGGRVQSVVTRIIVDREEEIEAFIPEEYWNLELLLKKTDDPIEFISKFYSEDGKKKTITIAEEAQRLEKIVDANAIIVDKVKKRIRYQKPPVPFTTSTLQQEAYKVLGYTTQRTMRLAQQLYEGVEIKGSGLTGLITYLRTDSTRIADEAVLESKAYIKQHFGDEYLGSEKKVGKKKNVQDAHEAIRPSSIMLTPEKAKESLEPDQYRLYKLIWERLLCSQMSDAQYYVTDVDIACNNLIFKTKGETQKFDGFTRVNRNPNKSEDSILPELSVGDDLIRLKTTKEQKYTKPPARYTEASLVKILEEKGIGRPSTYAPTIATIKNRDYVEVIEKHFKPTELGVTVTHLMKEYFSDVVNISFTADMEDRLDSVSEGKTDWVELLRNFYGDFEKALTNAQEKAEAVTIADPESDEDCELCGRRMVIKKGKYGRFLACPGFPECKNTKPFFEKTGGICSLCGGDIVKRTSKTGRTFYSCNNYPDCDYMNWDMPIPEKCPVCGSTLFQKGLGKRKSIYCDKKDCGYKAAPKE
(1351) DNA topoisomerase [Desulfosporosinus orientis DSM 765]
7
MKRTLIVAEKPSQAREYAVALGVKRKGDGYLENDQYVITWCYGHLLELERPEAYMDLEQVGRRWSLRRLPVLPSLNDFRRVVKKESAKQYQVVLNWLSSSEITQVICGTDADREGQLLFQEIWDAANCRKPLSRLWISSLTTAAIREGLKNLRSAETVAGLAAAGNGRAFADWDFGMNLTEGFTALFGSFDTERKRPNVISIGRVQTPTLALIVEREWEIESFVPQQFYEVKAEFKAEQGNYYGKWIDPGDDTKRITDLQEAESIVLKTQGKLGSISEMEEKEILEPAPLLFDLTSLTIAGSKKYGYSAEKVLQLAQSLYEKKAITYPRTDCAYLSEDILPKLPAHLNAVCQEPYKDLADQARGFGLPKGKRVINTITAHHAIIPTTEKVVLERLNRDEQHLYDLIVRRFLAVWFPPARYYQTVVMTLVESETFRTKGKALLSLGWKAVYDHSDLKKHGSAGEEEEAALPPLLKGQVVQVKEVSWDEKSTKPPKPYTQGDLLKAMEGAGKQIDDEILRQQLKGKGLGTVATRPAIIESLIDRGYIFQKQKSLRPSAKGVELIRLIKEKLPEAHLLISAEMTGQMEYNLAKVEKGEIPIQSYMSEVENSVKRIVAELRSFEQCHGKSPLAFAPAVKVSRKGKKKEEGEKTVRQKEKTSDSSAQSLGKCPKCGSEVIEGQKGFGCSNWRSGCRFVLWKTPICGKTLTPNQIRRLLKTGKTPLIKGFKSKSGQSFAAYLIWENPAEAKLTFRFKKE
(1694) DNA topoisomerase 1 [Desulfosporosinus orientis DSM 765]
1
MSKTLVIVESPAKAKSISKFLGSRYTVKASMGHLRDLPKSQMGVDLENDFEPKYIAIRGRGDLIKELRAAAKSADRVFLASDPDREGEAIAWHLSYLLGLEQTDKIRIEFHEITKQAIQTAIKHSRHIDQDRVDAQQARRVLDRLVGYQLSPLLWRKIKKGLSAGRVQSVAVRLIDDREEEIRAFVSEEYWSLTAELQFAGGKFLAKLVKKSGKKISISNRTEMETVLEELKGKEFKVSDVRTKEKKRLPAPPFTTSSLQQEAHRKLGFSPKRTMMLAQQLYEGLDLGKEGTVGLITYMRTDSVKIADIAQTEAKEWILGNYGGDYYPPEPRQFTTKGRAQEAHEAIRPTLPLRTPDALKGILSRDQLRLYRLIWERFMASQMSVAVVDTLTVESLVDEYLFRANASTVRFPGFLAIYEEGNDDTEAKDEEQNSLTISVSPGEQLKLIKLQEKQHFTEPPPRYTEASLVRKMEEEGIGRPSTYAPTIETIQTRGYVVKEEKQLLLTELGDIVITLLKEHFPDIVNLEFTANLEEKLDLIEEGKAPWKAVVEEYYQPFSVTLAEAEEKIGKVKIEDQVSEEICENCGRNMVIKMGRYGKFLACPGFPECRNTKPLFEEVGTPCPNCSKPLVVRRSKKGRKFYGCLGYPECDFVSWEMPAPEPCPECGQLMVVKSTKRQKKHVCTNRECRHTIVIEEEG
(1129) DNA topoisomerase 3 [Desulfosporosinus orientis DSM 765]
2
MGKTLVLTEKPSVGREVARILHCNQKGKGCFIGPNYVVVWALGHLVTLADPELYDEKYKDWKMEDLPMLPDKMELVVMKETAKQFGVVKNLMRSQEFSDLIIATDAGREGELVARWIIKKAGWKKPLKRLWISSLTERAIKEGFQHLKPGKEYEALYAAAECRAEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREQEIKNFVPKDYWTINLRARGFNLRWQDSNGQTRIFAKEKAEALAAKLKGHSGEVVEVKRDAKKELPPLAYDLTELQRDANRKYGFSAKTTSSVMQQLYENHKLVTYPRTDSRYISEDMVSTLPERLKSIALGPYVNLARGILRNKPIVTKRFVDGSKVSDHHAIIPTEQPPALSRLNSEELKIYDLIVKRFLAVLSAPFEYEQTLVKVAVQKEVFTAKGKIVKKLGWRSVYEGQGTWDDDSDDGEKEAEQTLPEISRGEILSNLSVDLASGKTKPPSRHTEATLLSAMEHPGKLIGDQKLREAMEQSHGLGTPATRAEIIEKLYNSFYMSRQGKEIVPTSKGIQLIGLVPAELKSPVLTAKWEQQLTEISKGKVNSQAFLKGIRGYTIQLVSTVSGSTQTFKHDNLTRNKCPECGKYLLQVKDKKGEMLVCQDRECGYRKRLTQISNARCPECHKKLELKGDGENKFFSCVCGYREKLSVFTKRREAEKGKMNKKDVSRYLHNQKDDGPINTALADALAKFKKQQ
(1714) DNA topoisomerase 1 [Eubacterium limosum KIST612]
1
MAKNLVIVESPAKAKTIKKYLPKGYEVQATMGHVIDLPKSRIGIDIEDHFKPDYIKIRGKGELLKKIKKEANKADNVLLATDPDREGEAISWHVANFLGIDLDTKCRIEFHEITKRAVNAAIENKRAVDMDLVDSQQARRILDRLVGYSLSPFLWKKVKKGLSGGRVQSVVTRIIVDREEEIAAFVPEEYWGLDLELKKDKDKNIFLSRFYSEDGKKKTIKNAEEAARLEQVVLHNPITVAGVKKRVRKQKPPLPFTTSTLQQEAYKVLGFTTQRTMRIAQQLYEGVEVAGKGLVGLISYIRTDSTRLADEAIAEAKDFIETNYGPDYQQSSAKKTVKKKNVQDAHEGIRPSSVFNLPEEVRDSLEKDQYKLYKLIWDRMVASQMADAEYYVTDVDVACANLLFKTKGEIMKFKGFTAVYRTASSAEKEEANRLPEFEDNEELNLVKINKEQKFTKPPARYTEASLVKILEEKGIGRPSTYAPTIATIKSRDYVEVVEKHFVPTELGITVTHLMKEYFEDIVNLTFTAEMEEKLDKVADGETDWVKLLESFYGGFKKELDHAQEAAAEVTIADPESDEICELCGRRMVIKKGKYGKFLACPGFPDCKNTKPYFEKTGGICPECGGDLVKRTSKKGRTFYSCSNYPNCEYMSWDMPVAEKCPECGQTMFQKGLGKRKKVYCAKCGFEKSADQQ
(423) DNA topoisomerase [Eubacterium limosum KIST612]
3
MKDLILAEKPTVAVNIAKAVGMTSRKDGYFENSQYVITFAVGHLLELYDVKDYHPEYGEKWEISHYPFVPDTFKYKIAESTRKQFKIVKDLILSDEIQEIISATDNDREGQLIADLIFRYLGVKKPIRRLITNEWTTDAIRYGLKNTVPNKSKQSLFYAGLVRQQMDWLLGINLTSVATLKLLKNGTGKDTLHIGRVILPTLKLVYDREMNVKNFKSIPIYYLNAYVKDVSGEEIIFRYIEGDEKIYKFDHDSHLVQILRLINTETAVVVGYECSEKKMNPQRLFSLPTLQGHITTKYEGWSSDKVLKIAQKLYENKLITYPRTDSVYLDETLKENMSMVLNIHKIESQYAEMLQFKDTKRIFNSEKVESHSAITITKEKPRGLSQDEHIVYEAIRNRFLEQFMPLAIDEEVEVTLAFEGKVPSEDGAFLFSAKSIVERSPGWRLIENRNATKKETLLTRMRENESVTIDRVMVNKGETKPNPLHTEETLIKAMLQCGKKYKTEDELETSILSGFTIGASSSRAAVIKKLFDSDYVIKKGKSLVTTDRGKSLIQAFPVKSLFNVETTGKMEMRLKDIEEGKADPRAYLEDVKIKTKEYVQMILETEQFVLNAGEDISIKELRCPKCGKPLHKTKSGVGCTGYEKEGNGCDFFIANPFAGKTLSNRQIALLVINKKTPIIRGFKSKKDTKFDAMLALNHQYEIKFEFQKSETDLACPLCGKPLKRNKAGMGCSGWKEGCKFMIFNPYCGKRLSDNQIEQLIKRGHTGEIKGFKKKSGNGTFSAILYLDDSDQYKVKMKFE
(1648) DNA topoisomerase 3 [Eubacterium limosum KIST612]
2
MSQNKTLVLAEKPSVGKDIARVLKCKNGQNGYLENDRYIVTWALGHLVSLADPEAYGEKYQNWNMESLPMLPEHMKLTVLKGSGKQYKIVSSLLGRSEVKDIVIATDAGREGELVARWILDKAHCHKPIRRLWISSVTDKAISEGFKNLKPGTEFNNLYRAAQCRAEGDWLVGLNITRALTVKYNAQLSAGRVQSATLNMIVEREEAIKNFKPKPYYNILAKTPQFTLTWQGQHGKNINSKETAEKILQKMKGKSAVIKDISKKPKKSTSPGLYDLTELQRDANRLFGMSPKETLNIMQRLYESHKILTYPRTDSKYLTQDIVPTLSERLKTISIGPYKAAVSEILKLGIHTNKSFVDDRKVSDHHAIIPTEQRVILANLSTDERKIYDLVIKRFLSVFLPPYEYLQTTVTADIAGEALTAKGREIITLGYKKVYENQSEEDDDEDNEDQQLPSLKKGNALAVSQISLKELETKPPARFTEATLLSAMENPQKVVKVDAKAAKTLGETGGIGTVATRADIIEKLYKMFVIEKKGNSLYPTSKGKQLIDLVPADLKSPLMTAKWERQLELISKGKSDPEAFIADIKTYTTELVNDVKNSNEKFVHDNKSGQKCPECGKNLLEVKGKYGMMLVCQDRTCGYRENVSKNTNVRCPECHVKLEIRGKGDGALYFCKRCGFREKVSSFNKKHFDGNRKNSKREAQNYMRKMKKENQEAVNNPFAEALAKLKESE
(552) DNA topoisomerase 1 [Butyrivibrio proteoclasticus B316]
1
MASKTTTTKKNSLLIVESPTKVKAIKKFLGNGYDVAASNGHVRDLPKSQMGVDVEHDFEPKYITIRGKGDVLADLRKKVKKADHVYLATDPDREGEAISWHLIAALKLDEADAKIQRVTFNEITKNAVKEAMKHPRDIDMNLVDAQQARRVLDRMVGYSISPLLWSKIKRGLSAGRVQSVALRIIADREEEIESFIPSEYWTLDVNLAAEGEKKPLVAHYYGTGNDKKEIKSKEELDKICASLKGAKYVVSDVKKGERNKKAPLPFTTSTLQQEASKALNFSTQKTMRVAQQLYEGIELGKQGTVGLITYLRTDSTRVSDEAVAAANAYISSNFGDKYLSEGTTAKKSDAKIQDAHEAIRPTYVENTPVVVKEFLSRDQFRLYQLIWRRFMASRMAPAKYETTSVKIDAGEHRFTVAASKTVFDGFLNVYTDEDDQIEKNVLMKNLDINTKLSFDSFDSAQHFTQPAPHYTEASLVHDLEALGIGRPSTYAPTISTILARHYITKENKAIFITELGQAVNKMMNDAFPQIVDVNFTSNMEALLDGIADGNVKWKTVVENFYPDLNEAVEAAEKEMEKIQVQDEVTDEICPNCGRNMVIKYGPHGKFLACPGFPECKNTMPYFEKIGVECPKCGKDLVLKRTRKGRIYYGCIGSPECDFMSWARPVKEKCPKCGKYMVAKSNKLACSDQECGFSCNKDELKKE
(294) DNA topoisomerase [Butyrivibrio proteoclasticus B316]
7
MAKKLIITEKPSVARDFARVLNVSGNNNGYIENDQYVISWCFGHLVEMVYPEEYDPKYKKWRLEDLPFLPAKYKYGVIKNSADQYKLINNLLHREDIDTVYWAGDSGKEGQTIEENIRNYGGVRDGMTELRVWIDSMTDEEVRRGIAQARPMSDYALLGESGIMRAIEDYSLGINFSRALSVKYGKLINDAAATKSYTAIAIGRVMTCVLGMVVRREREIRNFEKTPFFRIVGSFSDAKILAEWKAVSGSAYFESPLLYKENGFKKEDSAKALIDSFNGKEAVIDSIETGNSKKRAPLLYNLTELQADCTKRFKISPSQTLEIAQELYEKKLTTYPRTDARVLTTAVAKEIYKNVKGLSAVNEVSGFVDHVLKNGLYKGIEKSPYTDDSKVTDHYAIIPTGQTSAMGSLSPLAMNVYLLICRRFVSIFYPSAEYKTAKLQIAVGNEKFFAAAKVLVSPGYLEVAGIPKDKKAEDKKGDEEGNSSEDEEDVGISKEEFLKFVENAHKGDRISVNDYMIKEGATAPPKRYTSGDLVIAMENAGNLIEDEELRETIKKKGIGTAATRAAIIQKLIDNKYLAQSKSQIITPEKLGEMIYEVVYLSVPTLLNPEMTASWEKGLEGIYNGSVNGQDYRAKLEEYIRRETGKLIEKDLTTEIVGRINQFTGKESKGLASRKPIGIKCPVCGGEITTTSFGYGCSNYFNDQIKCTFSVGRIAGKDLDEETVKTLITEGKTGVIEGFVGKNKSSFSASLRLGKDENGKYAISFNFDDVPTVYVDNMNCPACGGRIIRTVNGYSCENRGKEEGGCYFYLGEVAGKKLTEEQVRTILSGEETEVIRGFKSKNNKPFNAKLVMKTSENGKKEITFDFEGVEPDYLADVVCPDCGGRIIKKTVGFGCENFKADDPQSCKFFIGKIAQKQISEANVIELLKEGRTGTIRGFKSKDKKPFDACLVMKKNENGVSEISFDFENVEAKTVKGVTCPLCGGDIVKTPFGYGCSNYKKDDPENSCKFNIGAIAGKNLKDAQIKELLLTGETTKISGFKSKSGKPFEAKLALDKGEDGKVKGIRFVFESEDEVMEDAKCPICGKQIIKGHLGYRCEDYKKGDEGCSFFIGKIAGVMIDKENFKKLVNEKITDKIAGFTSKKGTSFDAKLAFDEKFNVVFNFDN
(712) DNA topoisomerase 1 [Roseburia hominis A2-183]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVVASNGHVRDLPKSQMGIDVEHDYEPKYITIRGKGDILAKLRKEVKKADKVYLATDPDREGEAISWHLSQALKLDGKNVRRISFNEITQNAVKASLKQPRDIDMNLVNAQQTRRILDRIVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWTLDAKLKADGEKKPLTAKFHGDENGKLAITCREEADRIMDEIRGERFEVLEVKKGERVKKAPLPFTTSTLQQEASKTLNFPISKTMRIAQQLYEGVDVKGQGTVGLITYLRTDSVRISDEADADARAYIAQNYGEEFVATQTVTQKGGAKIQDAHEAIRPSDIARTPAVVKESLSRDQFRLYQLIWKRFAASRMASAVYETTNVKIGAGKYRFGVAASKVSFEGFMSVYTSEDDEKDTNNVLLKGIDEDTKLTLDTFDEKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTITTLLGRRYIVKEAKNLYVTELGEVVNQIMKESFPSIVDEHFTANMESLLDSIGEGAVNWKTVVRNFYPDLEAAVEVAEKELQKVKIEDEVTDVVCDQCGRNMVVKYGPHGKFLACPGFPECRNTKPYLEKIGVPCPKCGKDVVLRKTKKGRKYFGCENNPECDFMSWSRPVAEKCPKCGGYMVVKGNKIACADAGCGYTRDRKADEDTK
(610) DNA topoisomerase III [Roseburia hominis A2-183]
7
MAQHKLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGEMIFRSVYELAGCKKPMKRLWISSMEDSAIRKGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPIPFYTVALELPGLTVSGERMADKAAAEQLKEACQGVNVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVANAMPFRKGIAITCDPQTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLMCAVAQPHIYSETVVIAACAGGEFTTKGKTVKHPGWKALEDAYRAKMKDTEPKKEGVEKALPELTEGQTLSVSAAIVKEGKSSLPQHFTEDTLLSAMETAGKDDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKNRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIERGQLAPEEFLDGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQNDSCKFAIWKNNKWWAAKKKQPTKAVVSALLNDGCVRVTGLYSEKTGKTYDAAVVLEDDGQYANFKLEFDQRKGGSR
(1268) DNA topoisomerase [Roseburia hominis A2-183]
7
MQLVVTEKPSVAQAISHVIGAKERKDGYMEGNGFLVSWCVGHLVELAQPEMYSEAWKKWSYESLPMIPEQWQHEVKKETATQYKILKNLMHDTRVESVVCATDAGREGELIFRLVYEQAGCRKPMKRLWISSMEESAIRDGFENLKPGSDYDSLYQSALCRQQADWLVGLNGTRLFTVLYGGKVLKVGRVQTPTLAMLVDREVKIMNFEKEQYYMAHILMDGIDAMTERIDDKARAESIAAACESQSGVVRSVIKENKSVAPPKLYDLTTLQRDANRIFGFTAKQTLEYTQSLYEKKLVTYPRTDSQYLSDDMEETAKAVIGAVYQAILFEEQTGAEPDIKRVLNSKKVTDHHAIIPTIEITKTDLSAVPEGEMKILSLVANRLLCATGKKQLYETVKAEFSCGGYSFHVSGKTVLQNGWKEFEAALKRTYRVEKTDEDKEEKKLPELSEGMTFPVIQTKVTEHFTQPPKHFTEDSLLSAMERAGAEDMGDEVERKGLGTPATRADIIEKLVKDGFVKREKKQMLPTEDGMKLITVLPDMVKSPKLTADWENTLTLVEKGEYTMQEFMDGIEDMVRELVQTYHSISDDQKSLFGTMQEVLGKCPKCGSDVVKGKFGAYCKQKCGMNVGRAMGATFSDTQMKSLLEGKKTLVRGLKGKKGSYDAYLIPEGIEDYSYIKDGKEIKGSQYKFKMEFPPRKSK
(10) DNA topoisomerase [Roseburia hominis A2-183]
7
MAKSLIITEKPSVAQEFARILGVSGRNDGYIENDGYVITWCVGHLVEMVYPEEYDERYKKWRLEDLPFLPRDYKYNVIPSVSRQYDVVHKMLHREDIDTVYWAGDAGKEGQTIEENIRKFGGVREGMKELRVWIDSQTEEEILRGIREAKDMSEYDNLAKSGVMRTIEDYAMGINFSRAMSVKYGKLLNDAAGTSSYTAIAVGRVMTCVLGMVVIREREIRNFTETPFYRVVGTFHPEGEEECRITAEWKAIEGSKYFESPLLYKENGFKKEESAQTLIAELKGQEALIDSVETGTQKKRAPLLFNLAELQAECSKRFKISPDETLQVAQDLYEKKLTTYPRTDARVLSSAVAKEITKNISRLKNFAPVAPYVERIMKEGRCRNIANTQYTDDSKITDHYAIIPTGQLTELESLNSLERSVYEMIVRRFLSIFYPPAEYQTVKLVVAAGGEKLYTSAKQLKVPGYLEIAGIPKSAKERNAAKTDGEEQTQGGDAEAAQEEEENAGLLAYADKLQKGETLFSDGYVIREGKTSPPKRYTSGSMVLAMENAGQLIEEEELREQIKGSGIGTSATRAEIIKKLVRVGYLNLNKKTQVLTPERLGEMIFEVVSMTVPALLNPKMTASWEKGLDGITRGAVVMEDYRSKLEDFIRRETVAMIEQDLTGQIATRIHPLVGKGGKGLAAKRSLGIPCPVCGGTIETTPFGYGCSNYQKDGGGCRFSIGTIAGRDLNDEEVKELLTEGHTGVLSGFVSKSKKKFSASLILEKDDEGKVSVGFDFSKNQPEILEGVVCPVCGSAVEITPFGYSCVKHHEHPDECYFSVGKIAGKALGVDDLTELLTTGKTGLIRGFTARNKKKFNACLKLEQTEDGRKNIAFDFSQNDAAVVPDVVCPICGGAIVETSFGFGCANYRQDDPDSCRFAIGTMAGKDLNAAQVKELLNQGRTGTIRGFKSKSGKKFDACVALEHTEDGRIELRFDFEHVEAKKIKDVVCPICGGDIVATPFGFGCANYVKDDPNSCRFSVGKMAEKALTEANVKELLTNGRTGTIRGFKSKSGKKFDARVALAKDEKGKVTGLKFDFTDLEAPKVKDVKCPVCGGDIVKTMFGYGCANYSKENPDSCRFAIGKIAGVSLKEAQVKELLLRGKTDVIKGFVAKTGMKFDAPLKLTPEGQIAFDFPEKPKPVETTLACPKCGKMLKKSQWYYECECGFKVSHTVAKVALTEEVMRELLETGKTKDKVTGFVSKAGNTFDTCLKLEDDRIVFDFDNPGTKREGASDGKGGERMFYEELEENAQPQPLAAEDGAQYIEEDVPPFYDAMAEEYAAYEEEEAKQQAAASNFLDEFPG
(965) DNA topoisomerase 1 [Thermincola potens JR]
1
MSKVLVIVESPAKAKTIGKFLGSRYRVKASMGHIRDLPKSQVGVDVEHDFAPKYITIRGKGEILKDLKQAAQKSSKVLLAPDPDREGEAIAWHLMHYLDINEKDKCRIEFNEITKDAIVNAIKEPRTIDRHRVDAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEIKAFVPEEYWDITGVFTGTDKKWTIEAKLLQKGKEKIHIGSEAEAQAILDDLKDASFLLTKLRKKEKKRNPVAPFITSSLQQEAYRKLNFPARKTMQVAQQLYEGLDLGPEGTVGLVTYIRTDSTRVAETAQAEAREYIKGKFGTGYVPEKARQFTTKGKIQNAHEAIRPTSVFREPDQIKNFLSRDQYKLYKLIWERFVSSQMSPAVLDTTSIDIEAGDYTFRAHGSIIKFPGYMKIYTEGKDEDDNEEEKTLPENLEEGLRLIAKSLVPKQHFTQPPPRYTDATLIKALEEHGIGRPSTYAPIVETIQKRGYVVKEQKQFHPTELGMVVVELLKEHFTDIIDIQFTAAMEEKLDLIEEGDMDWVQVLKDFYLPFKDTLERAEKVIGQVELEDEVTEEICELCGRNMVVKMGRYGKFLACPGFPACRNTKPLLEETGVKCPHCDGRLVLRRSKKGRKFYGCSNYPDCDFVTWDLPTEKKCPKCESMLVQKKFKNKGAVYQCISENCNYKEKAETITI
(1039) DNA topoisomerase 1 [Desulfotomaculum carboxydivorans CO-1-SRB]
1
MGCTNLSKTLVIVESPAKAKSIGKYLGRNYTVKASMGHLRDLPKSQFGVDVESNFSPKYIAIRGKGEIIKELRAAVKKADRILLASDPDREGEAIAWHLSKLLDIDENSNCRIEFNEITKQAIQQAVKHPRPIDIDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLIVDREEEIKAFIPEEYWSLTAKFSKTAKSTFEAKLYKYQNKKITIPNQEAMDKILADLKGVSYVVASVTRKEKLRNPAPPFTTSSLQQEASRKLNFTARKTMAVAQQLYEGLELGKEGPVGLVTYIRTDSTRVSETAVEEAKKFILERFGPAYVPKESRQTVAKGKVQDAHEAIRPTSVERDPETIKEFLTNDQYKLYKLIWSRFLASQMAAAVMDTTSMDIEGGDYLFRATGSIVKFPGFMQVYIEENDDGTKEEEKLLPELAQGDKVEAKSLTPKQHFTQPPPRYTDATLVKVLEEKGIGRPSTYAPIVETIQKRGYVVRENKQFYPTELGIIVVDLLKNYFPDIINIEFTAEMEEKLDQIAEGDQDWVNVLKDFYGPFQQTLATAEEKIGKVQVADEVTDEICEQCGKNMVIKMGRFGKFLACPGFPDCRNTKPLLEPTGVACPRCEGELVLRRSKKGRKFYGCSRYPECDFVTWDVPTNEKCPHCGDLMVEKSSRGKEKILQCVNENCPSNAGVKETKAGQKTKQTTSNK
(320) DNA topoisomerase 1 [Thermaerobacter marianensis DSM 12885]
1
MPKTLIIVESPAKAKTIKKFVGRDYTVEASMGHVRDLPKSQLGVDVDDHFTPHYITIRGKGKLIERLRQQARQADRVLLATDPDREGEAISWHLCQLLEIPQDSPCRIVFHEITRDAVRRALKEPRPIEENLVDAQQARRVLDRLVGYKLSPLLWRKVRRGLSAGRVQSVAVRLIVDREEEIEAFTPQEYWTLEADLQRRAGGEVFTARYHGDAEGKKDLPNRDAVDRLLADLEGRSFTVLGVERKERRRNPAPPFTTSTLQQEASRKLGFSVRRTMRIAQELYEGIELRGEGAVGLVTYIRTDSTRIADQALDEAAAYIAERFGPEFSAPRKQAGRRQAQAQDAHEAIRPTSVAREPDAIKDDLTPDQYKLYRLIWERFVASQMAPAILDTVTVEIGAGPHRFRATGSTVKFPGFMQLYVEGRDEGTEGEGDEGEGMLPELAEGDALDVRALRPEQHFTQPPPRYTEAMLVRALEEKGIGRPSTYAPIIETIQERGYVVKEDRRFRPTELGRVVTALLKEHFPDIVDVEFTARMEADLDRIEEGERNWEDVVRDFYGPFSETLSRAERQIQRVTLPVEETDEICEKCGRRMVIKHGRYGRFLACPGFPECRNTKPLVEKTGARCPRCGGEMVQRRSRKGRVFYGCSNYPECDFTTWDRPTAETCPECGTFLVEKRSRQGVRLVCANPQCNYEREAAGETAGAGAGSGRR
(773) DNA topoisomerase 1 [Sulfobacillus acidophilus TPY]
1
MESPAKAKTISRFLGSRYQVKASMGHVRDLPKSQFGVDLERGFEPRYITIRGKGPLLKELKDAAKKTDRVYLATDPDREGEAISWHLAESLGIPLAEARRIEFHEITKDAVTEAIRHARPIDMHLVDAQQARRVLDRVVGYQLSPLLWRKVRPGLSAGRVQSAALRLLVDREDQIQAFQPEEYYTVTLTLDTQPVMTAQYAGPLGEKGRLSPVDAQTVVGRVKKGQTVHVESVKTRERRRFPALPFTTSTLQQEASRRLGFSVKRTMSIAQQLYEGLDVQGEGTVGLVTYIRTDSTRVADVAEAEARQFIESQYGTAYWKGLGAAKRPEKERPGVQGAHEAIRPTSVMRHPDRLKASLTRDQLRLYRLIWERFVASQMAPLVYDATTVELSVGEDRFRAHGAVVKFAGFTVLYQESAADDTKAANEDDAGQGPLPVVQEGQTLTATAVEAEQHFTEPPPRFTEASLVKTLEELGIGRPSTYAPIIDTLLQREYVQREQKRLIPTPLGRLVVELLQKYFPEIVDISFTANVENQLDRVESAELGWREVLTDFYRPFAEELAKAEQDLEKVAIPVEETDEVCDQCGRPMVVKYGRFGKFLACSGYPECTATKPFVEKTGAVCPKCGDQLVVRRTRKGRTFYGCHSYPACDFVTWLRPTEKTCPRCGSSMALRKKGRQETLTCLKEGCGYEEQAQ
(9) DNA topoisomerase 1 [Desulfotomaculum kuznetsovii DSM 6115]
1
MSKTLVIVESPAKAKSIGKLLGKKYTIKASMGHVRDLPKSQFGVDVEHGFTPKYITIRGKGEIIKELRTAVKKADRVLLASDPDREGEAIAWHLANVLEIDENAPCRIEFNEITKQAVQNAVKAPRPIDYNRVNAQQARRILDRLVGYKLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEINAFVPEEYWTLTAVFTRRGKDPFEAKLYKIGDKKAEIKNQAQIEEILKELKGVSYRVVKITRREKTRQPAPPFTTSSLQQEAYRKLNFTARKTMMVAQQLYEGLELGKEGPVGLVTYIRTDSTRVAVQAQMDARAYIQEKFGPGYVPEKPRQVAARGRAQDAHEAIRPTAVEREPEAIKQYLTPDQYKLYKLIWSRFVASQMSPAIIETTSIDITGGHYTFRAAGSVVKFPGFTRVYVESRDDETKEEEGVLPALSEGEALEVKSLTPKQHFTQPPPRYTDATLVKALEEKGIGRPSTYAPILETIIKRGYVVREKKQLVPTELGMVVVDLLKKHFPDIIDVEFTAQMEESLDRIEEGEMDWVRVIQDFYGPFQETLARAEEEIGQVTVSDEVSEEICEQCGRNMVVKMGRYGKFLACPGFPECRNTRPLLEPTGVPCPQCKGELVVRRSKKGRKFYGCSRYPDCDFVVWDEPSGEKCPRCGGILVIKKGRGEQEELECVNEQCRYRVDREKKAGSNGEAARDVAAGSKLVEEKPSFDSWHNDALLPLMRAKSGRTATRGTGGRS
(679) DNA topoisomerase [Desulfotomaculum kuznetsovii DSM 6115]
7
MRKLVIAEKPSVARDIASALGKFAQKDGYLENDRLVISWALGHLLELADAHEYDPAFVKWTLEPLPIIPEEFKLHPIRSGAKQLKILKQLLNSADVAEVINACDAGREGELIFRRIYEWCGCRKPVKRLWLSEATPSAIREAFKKLRDGRELDNLAAAARARAEADWIVGINATRAFSVKHKTLLSVGRVQTPTLALVVQREREIRDFKPETYWEVRATFQKSGGATYRGRWFRGGESRIKEKSRAEELVRAALAAGSGRVAQVEKRTKTEAPPLLFNLNDLQKEANRKYGMTAQKVLDAAQALYEKHKLITYPRTDSRHLTEALARDTLQKRLAALEKCPEYGELIRRIRPGMLPGKRYIDDAGVTDHHAIIPTDVTPDPSALNPAERQVYDLVVRRFLAMFYPPAVYDETAVVTEVGDETFISRGRVEIEPGWKAVYGPEEKEEKDGKDEDGESQPLPPLAEGETVGVEEAGAVERQTKPPKRYTEATLLAAMENAGRLLDDREMAETLKAAGGIGTPATRAAIIETLIKRGYIERRKKTLVPTPRGEALIDLVPEKLKSVELTAQWEDGLRRIEEGLDDARLWLVGLKNFTVEVVAMAKEQEANGAVHQKEVMGRCPLCGRDVLEYTKSYGCSGYRDGCNFAIWKETAGKKITAKQARELLQKGRTGVIKGFKSKAGKSFDAILTLGEDGKVNFEFADHAGQALGKCPLCGKDVIEGKKGYGCAGWKEGCKFVIWKEIAGKKIAANLAKELLQKGRTGVIKGFKSRAGKDFEAALVLGEGGKIEFEFKNRQEG
(398) DNA topoisomerase 1 [Syntrophobotulus glycolicus DSM 8271]
1
MPKTLVIVESPAKAKSISKFLSKNYQVKASMGHLRDLPKSQMGVNIEHDFEPKYIPIRGRGDLIKELKAAAKTADQVLLASDPDREGEAIAWHLMHLLGINQEKSSRVEFHEITKPTIQKAIKNPRKIDLHKVDAQQARRVLDRLVGYKLSPLLWKKIKKGLSAGRVQSVAVRLICDREEEIKVFESQEYWTLLAQFLCPGGNFSAKLIHKAGKRIEIKSRQEVDEIIVQLRRAVCVISDVKNREKKKQPSPPFTTSSLQQEAYRKLNFAPKRTMMLAQQLYEGIDLGKEGTVGLITYMRTDSVRISELAQDEAKEYILASFGSDFYPGRQNYTSKRRTQEAHEAIRPTSVLRTPDSAKEFLSRDQLRLYRLIWDRFLASQMSAAVYDTLTVDVAADKYTLRANASTVKFPGYLSVYEESTDETEEKQDGDDRCLKVNVTPGQKVELAEIKEKQHFTEPPPRYTEASLVKKMEEEGIGRPSTYAPTIDTVQTRGYVVKEERKLVPTELGEIVVSLLKEHFKDIVDLEFTANMEEKLDNIEEGQTQWKSVIRDFYIPFEETLNKAEAIIGKIKVEDQESDVLCEFCGRRMVIKMGRFGKFLACPGFPDCKNAKPLLEEVGVNCPQCGEKLVVRRSKKGRKFYGCSNYPECNFISWEKPAPVNCPDCNSLMTEKTIKQKVNYVCTNKDCRHTEEKVEEKKE
(1311) DNA topoisomerase 3 [Syntrophobotulus glycolicus DSM 8271]
2
MGKSLVIAEKPSVGREIAKMLSCHKKDQGYFTGPKYLVTWALGHLVTLADPEKYDQRYKTWKMDDLPMLPEQMELVVIKETSKQFSVIKNLMKMPDLDELIIATDAGREGELVARWIIKKAGWRKPIKRLWISSQTERAIKEGFAALKPAKEYDHLYASAECRAQADWLIGLNVTRALTCKFSAQLSAGRVQTPTLAMVVEREKQIKSFVPKEFWTIQAFTKGFSMTWHDKTNGQSRIFDQSKADQMIKKISGHDAEITEIKKESKKELPPLAYDLTELQRDANRKYGFSAKTTSSVMQQLYEYHKIVTYPRTDSRYITEDIVSTLPERLNSIAVGPYAQFAAKILKNKITTTKRFVDQSKVSDHHAIIPTEQPVHLQKLSNEEYKIYDLIVKRFLAVLSKPFEYEQTTVKADIRGELFEVKGKIVKQNGWKEVYQGTGNWEEEQEDEEREQTLPDLHKGERIPILEVKTKAGKTKPPARYTEATLLTAMEHPGKNIENEKLREAVKQTGGLGTPATRAEIIEKLFSSFYLERNGKEIFPTSKGLQLIELVPVDLKSAELTAKWEQQLSEISKGKVKSTEFLNGIRSYARQLVSTVSENNQVFRHDNLTRNKCPECGKFLLQVKGKKGELLICQDRECGYRKGLSVSSNARCPNCHKKMDLKGEGENRIFTCTCGYREKLASFTQRKSENPGKVNKKDVQKYLNKQEDNGMINDALAQALAKLKK
(995) DNA topoisomerase 1 [Lactobacillus plantarum WCFS1]
1
MAASTTKAKPAAKRKTATKTATKRKSKTPAKKLVIVESPSKAKTIEKYLGRSYKVVASLGHIRDLPKSKMGVDVDNDYEPHYISIRGKGDVIKGLRKEAKKAKAVYLASDPDREGEAIAWHLSYLLGLDPKDKNRVVFNEITKDTVKNAFKEPRSIDMDLVDAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSIALDLIIQRENEIKAFKPQEYWTIDSEFQKGRSKFMASFYGTHGKKQPLDDNDAVQKILGQLDRNGDFNVVKVVKKERKRFPAPPFTTSTMQQDANRKLNFRTRKTMMAAQQLYEGINVGGKEGSVGLITYMRTDSTRISSIAKHEASQFLHKEYGAEYAATKPVKGKLPEGAQDAHEAIRPSSVFRTPASIKDYLTKDQFRLYQLIWSRFVASQMTPEVLDTMAVTIDQNDVQFRANGSKTKFAGFTKIYDKTEKNNVLPDLSEGDVVKLSKTDPQQHFTQPPARYSEANLIKALEENGVGRPSTYAPTLDTIQRRYYVKLEARRFVPTELGEIVNDIIQEYFPDVVNVGFTASLEEQLDATEEGKENWVKVVDSFYKPFSKEVATAEESMEKIQIKDELAGFNCDICGAPMVVKMGRYGKFFACSRFPDCRNTKPIVKEIGVVCPQCKKGQVIERKSKKNRIFYGCSRFPDCDFVSWDKPVGRDCPKDGHYLVEKKVKGGKQVLCPNGDYTENVQK
(1615) DNA topoisomerase 1 [Lactobacillus rhamnosus ATCC 8530]
1
MADKKLVIVESPAKAKTIEKYLGRTYKVVASLGHIRDLPKSQMGVDVENNYEPKYISIRGKGDVIKSLKKDAKKASRVYLAADPDREGEAIAWHVSHILGLDPNAKNRVVFNEITKDAVKNAFKTPRGIDMDLVDAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKNFIPEEYWSLDAEFQKGRSKKFSASFYGIKNKKMALKNNEAVQKVLSQIDKAKPFSVTNVVKKERKRFPAPPFTTSTLQQEANRKLGFRTRKTMMLAQQLYEGINLGGKLGTVGLITYMRTDSTRVSNVAKTETSHYLHEKYGEAYAAVKIRQGKLQEGAQDAHEAIRPTSTLRTPESLASVLDKDQMKLYRLIWSRFVASEMTPAIIDTVAVTLNQNDVTFRANGSQMKFEGFTKLYVSSRDSGEKDNVLPPLAVGDAVKMLKTDPAQHFTQPPARYSEANLVKALEENGVGRPSTYAPTIETIQKRYYVKLNARRFEPTELGEIVNSLIVEFFPDIVNIKFTANVESELDSIETGEANWVKVIDQFYKPFEKEVAHAETGIEKIQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKAIVKEIGVICPKCHKGQVVERKSKRNRVFYGCSRYPDCDFVSWDKPVGRDCPVCGHFLVEKKSKAGTQVVCPNNDYKEALQKA
(116) DNA topoisomerase 3 [butyrate-producing bacterium SM4/1]
2
MKSLVIAEKPSVGKDIARVLGCRKSADGCLEGDKYIVTWAFGHLVELAAPEEYDKKYKDWNMADLPMMPEPFKLEVIGKTAKQFGVVKRQLFRNDVKDIVIATDAGREGELVARFILMKAGCRKPLKRLWISSVTDRAIKEGFSRLRDGREYNHLRDAAMCRAEADWLVGLNATRALTCKYNAQLSCGRVQTPTLAIIAKREEEIRNFRPKAYWGLTARTSKPALTLTWQDKKSGGMRSFDRDRMEGLQKSLRDQQVWITKVKKTPKKTMAPLLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDVADTIHDRLAACGTGPYRKLAGKLSKNVWTKKASFINDGKVTDHHAIIPTEQFVQLQNMTSEERKIYDLVVRRFLAVLYPAAEYDETVITAEIGGEIFTARGKVMRTPGWREVYESADESGLSGTGGYLDEEDGDEDGEGPQNERVKAQTLPDLREGDVIGPAGISLTEGKTKPPAPFNEATLLSAMENPVRYMESGDRAMAKTLGETGGLGTVATRADIIEKLFSGFMLEKKGKDICLTSKAKQLLRLVPEDLRKPELTAQWEMRLSKIAKGEMKRDAFMEDIRTYTKDIVEEIKGGEGTFRHDNLTNTKCPRCGKRMLSVKGKNSQMLVCQDRECGYRETISRTSNARCPKCHKKMELRGKGENQMFSCVCGYKEKLSNFKERRQREGAGVTKRDVARYLNQQKKEEKMVNNPFADALKKMQEQDV
(1040) DNA topoisomerase 1 [Clostridiales genomosp. BVAB3 str. UPII9-5]
1
MDKTLVIVESPAKAKTIGRYLGKDYEIAASVGHIRDLPSSTMGVDINNDFKPRYINMRGKEKIINDLKAKAAANAHTLIATDPDREGEAIAWHLANVLHIDPLSLCRITFNEITKNTVKTAVEQPRAIDLDLVNAQQARRILDRLVGYELSPLLWSKVKKGLSAGRVQSVATLMLVEREEAIRSFEPQEYWLLSVHLAEEKQPLADFTAQFYGRLDASGKCVKEELPDASAVENIKKQIQEPYKVLEIVKRNRQRNPAPPYTTSTLQQDAARKLGFSAKKTMLIAQQLYEGVDLPELGATALVTYIRTDSVRSSADAVAGMRKIIVSTFGPEFVPAEPNHFKNKNAAQDAHEAIRPSHLELPPEKIKVGLSTEQYKLYRLIWERFLASQMTPAKLAATTINIAAGDIIFRVTGETVIFPGFLKVNPEKVAEKEMNILPDLEKNETLRKLELLEEQKFTQPPARYNEASLIKAMEEAGIGRPSTYAPTLSTIMERQYAVKENKSLIPTELGFLVTNILREHFKKLINIKFTAEMENDLDEVESGKLNWVELIKNFYPVFHAAIVKAQKDISKIVIPVEATGEKCPECGADLVIKEGRFGKFIACSAFPNCKFTKNAVEKVDGHCPRCGSDLVSRRSRRGSIFYVCSQNADDKNCDFISWDLPVDNEKCPECGSYMVWHRLRGRLYKRCSNDSCVTRKSKRGKTDKNVAGEKQANDTAEPSAVETKRRKNTPKEKKKDND
(1074) DNA topoisomerase [Clostridium kluyveri DSM 555]
3
MKLILAEKPSLALNIVKSIGNMNRNDGYFENRDYLITFAYGHLLRLYDVDNYFKRGKTKWNLDELPFVPEDFKFKIREDKGVKKQYEVIKNLIRRNDVTEIVNCGDADREGEVIVNNIISRIFKEENINKPVKRLWLPEQTTQTIRQELRNLKDNRDYKNLYNEGLARTYLDWTYGINLTRYLSIKSQTFLPVGRVLIPIVKFIYDRDRAIENFKPETYFEIGAVIKKDNLEIKAKLKDRRFSADEREKAANLLNSLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKQFKMSLDDTLKHLQKLYECGFTTYPRTNTEYLAENEKGKIKSIIEVMKEKFNVDIDFKDKKKIFDNNKVESHSAITPTTKIPEIEKLSEDEKKVYTAIRNRFISNFLNEETIIEETYVIIRIVDEVIELKGNVIKQTGFLKYENIKKENELPDFVEDEKLDTKLSVDEKQTQKPNRVTESELNNFLKNPFKKKEIQDLENTNDDEEYKMILEGCEIGTVATRAVIIKNAQKYEYIKEVKGHFECENKGIRLIDVLKRLNIDLDKGKTVEFGKQLKGVYKNDIEINTIIYNVKSELNNIIRKGDEIKIDRIESKKYESMGVCPICGKGNIMANKFGYGCSRWREGCKFFIGKQIAGKNISESMAKKLIKNKKTNVIKGFKSKNGKSFDAVLTIKDENVAFDFSSESKGLGTCPVCGKGNVIANKSGYGCDKWKEGCKFFIGSKIASKSITESMVKKLLKDKKTNLIKGFKSKNGEVFDAFLIIKDSKIVFDFKE
(878) DNA topoisomerase 3 [Clostridium kluyveri DSM 555]
2
MSKILVLAEKPSVGRDLAKVLHCNKKNLGYIEGDKYVVTWALGHLVTLADPEDYDERYKSWVLEDLPMLPDKLKLVVIKQSGKQFNIVKSQMNRKDIGEIIIATDSGREGELVARWIIEKARVKKTVKRLWISSQTDKAIKEGFANLKNSSKYDNLYKAARCRAEADWVVGLNITRALTCKYNAQLTAGRVQSATLAMIVNREEEIKNFKAKDYFVINAKTKEFTLMWRDKNNNSNIYEENRVNKILAITKGKAANIIDVRESYKKQYAPALYDLTELQRDANRIFGYSAKHTLSIMQRLYENYKILTYPRTDSRYISTDIVDTLKERLKAISVGSYKIYASELLKTRINAHKGFVDNSKVSDHHAIIPTEEVLTLSLLSSEEKNIYDLVVKRFLAVMLPPFEYVQTSIITDINGENFIARGKVVKSKGWKKVYDIGNQVIEDDENENQILPELKKGDSIDIISIESRRLKTKPPARFNEGTLLSAMEKPQKYISIDKLYAKTLGETGGIGTVATRADIIEKLFNMFYVEKNGKDIIPTSKGKQLIELVPEDLKSPLLTAQWEMDLELISKGKKDPEVFIRKMREYAGTLVEDVKESSNKFKHDNITGKKCPVCGKYMLEVKGKQGRMLVCQDRECGHRENLARLTNARCPECHKKLELKGEGEKRIYVCSHCSFREKFSSFNKRFKENEGKLNKKEVSKYMKKMNGENKANINSSLAEALANIKFK
(1521) DNA topoisomerase [Veillonella parvula DSM 2008]
3
MRLFIAEKPSMAREISKCLPENKNIQKRNGYFIQGDDVVTWVVGHVLHQAEPGDYDDKYIRWRPQDLPIVPAEWKLLVTDSSRQQFEIVKDLIDKADVIVNAGDPDREGQLLVDEVLYYVGNTKPVQRILLNALDEKSIRSALDDLRDNKDFHNLYQSALARARADWLIGMNLSRAYTLSERYKGNKVTLPIGRVKTPTLALVVRRERELAAFKPVDYFTVKVLYNHPNGVFWATWQPTDEQKGLDPDGRLINKAIADSLVEQLQSGPDGVIKAVTKSKKKDVQRLPLSLSSLQVLAGKAFSYDPQTVLDTAQKLYEKKLTTYPRSDCEYLPPNQYDDRNAILNNLQNAGDERLAQWAADADRSIKSRAWNEKKITAHHAIIPTTVACNINSLSQEERNIYFLISQAYIAQFYGEHIYEQTKIVVEQCKEEFVANGRVVIEEGWKLLYKRHKSKSTTDNDEPDLTDERGAESDPKKEIIEETDHLPAVKKNDTVLYTDSSVEAKQTKPPSRFTPSTLLQAMKEIHKFVKNEDLKKQLKAVSGIGTEATRANIIDELISRGFMKTSGKKQVLSPTETGYLLVDALPEELLYPDETAVWEERLALMSEGEDTLDSFLADQIKFLKLLIDKLGFDKVINSDQMMPNVVRTITSQNRKRPMDSESVDLSSLPVCPKCKKGRLQQRNGKFGAFLGCTNYPTCKHTQPVEGDTSSVEGNIEVSDEDKQYKCPRCNVGYFVKQEVRGRTNWICSNRSQCKTQCSDVDGVPSIYVNKSNIT
(1689) DNA topoisomerase 1 [Veillonella parvula DSM 2008]
1
MSIKRSIVIGEPKAASTSKDTKKKNTKKESTTIKRKVAKESLTPMGIVRDKSVLQTSVPPEQREPRVYNPDGKVLVIVESPAKSKTIEKFLGPNYVVKASMGHLRDLPKSQIGIDIEHDFTPRYSNLVTRKKVIDELVSYADESSAVLLATDPDREGEAISWHLAYILNVDPTSTCRITFNEITKNAVAEALDSPRTIDMNMVDAQQARRVLDRIVGYKLSPLLWKKVCKGLSAGRVQSVAVRLICEREREIQAFVPQEYWTIEGNFETPKKEAFIAELTHIKGEKIDITTESDAQAIVDAIGNEDAVVTNIEKRKRSRKAVPPFTTSTLQQDGVRKLNFGAKRTMMIAQHLYEGLEIGSYGHVGLITYMRTDSTRISKEMQAMAKDFILRNYGEDYYPSKPNVYGSKGSAQDAHEAIRPTSLELTPKMVEPFLSRDELKLYTLIWNRFMASQMAPQQNESTTIELNVKNDYTFKATGSRVIFPGFSAVYEDAKKEDVPQLPALKKNYAAHTVEVLPEQHFTQPPPRYSEASLIKTLEELGIGRPSTYAPILDTIVSRNYVENTNKQFVPTELGFVVVDFLITYFEKIINTGFTRDLEEELDAIASGKDTYVKVLSDFYEVFAQELEDASDVDRIEIASMESDEICELCNSPMVYKFGRYGKFLACSNFPECKNTKPITVGTGVTCPKCKEGEIVERKSRRGRIFYGCNRYPQCDFTLWDKPTHDFCETCGSIMVEKTYKNGTVKKFCSNETCPTRPPKKTRKKKSEASEEPVKESKKSSKAKKEETTIES
(194) DNA topoisomerase III [Oscillibacter valericigenes Sjm18-20]
7
MKLVIAEKPSVAQSIAAVLGAKQRGGGYLEGSGWLVSWCFGHLAELASAESYNPEYAKWKYDDLPIVPETWRFKVSRDKWQQFDILKKLMHSEDVSEVVNACDAGREGELIFRTAYCLAGCSKPMKRLWISSMEDSAIRDGFAHLRPGSDYDGLHQSALCRSKADWLVGINATRLFSVLYHRTLNVGRVMSPTLALIVQREAEIDAFRAEPFYTVELDVGFPAVSEKFREESQAKAVAAACQGQPAAVKSVERKEKSEKAPALYDLTTLQRNANRLLGYTAQQTLDYLQSLYEKKLCTYPRTDARFLTDDMEGSVPALVSVAATLYEAAAPGKIGAAQICDSKNVSDHHALVPTVSAGKAALSALPAGERKILRLVSRQLLCAVSEACRYAETVAAVECGGSVFTAKGRTVLAPGWKNYIQQEQPEKPLPDLTDGQALTVSGISTKEGKMTPPKHYTEDTLLSAMEVAGAKETPDDAERKGLGTPATRAAILEKLVSTGFVERKKAKKTVSLMPSHTGVSLITVLPEQLQSPLLTAEWEQKLKQVERGELTADAFLDGITAMLRELVKTYKAIKGAEVLFPSGREVVGKCPRCGGDVTESKKGFFCESADCRFGLWRDNKFLTAKRAVLDKKAVTALLKTGRVAMTGLYSEKTGKTYDATLVLEDDGQRANFKLEFNHG
(689) DNA topoisomerase 1 [Oscillibacter valericigenes Sjm18-20]
1
MAKQSLVIVESPAKAKTIEKYLGKEFRVKASMGHLRDLPKSTLGVDVEHDFDPVYQPIKGKEDIISDLKKSAKAADTVYLATDPDREGEAISWHLKQLLNLPDSKTHRVTFNEITKKVVQESIQEPRDIDQNLVDAQQARRILDRIVGYQLSPLLWKKIRRGLSAGRVQSVATRMVDDREREIEAFKPEEYWTLDAVFRGDDAKKTEFTAHYHGRDGKKVELKSAEEVEAVVEETRNQAFAVSAVKRTDKQRSPSPPFTTSTLQQDASRKLSMTPRRTMAIAQQLYEGVDIAGEGTVGLITYMRTDSLRISEEALSAAKSFILGRYGKDYYPARTRHYKAKANAQDAHEAIRPSNVALTPEQVKGDLTGEQYRLYKLIWSRFLASQMENAVYDSVSVDIAAGEHMFRATASGLKFAGYTAVYEEGKDEEKEEKESPLPALREGEPLALKEFYRDQHFTQPPAHYTDATLIRAMEEQGIGRPSTYAPTVSTIIDREYVIKEGKYLKITNLGRVVTELMKQRFSDIADLQFTAHMEQKLDSVEEGVTPWKNVLRDFYGDFEKNLKDAETALEGTRIKVPDEVSEEICPECGRNLVVKSGRFGRFLACPGYPDCSFTMPLVVVMPGRCPKCGGRLMKRTGVSKKTGKQYNYYCCEHRTARDEAAKCDFMTWDVPVKDDCPVCGQTMFKRSGRGYKRPYCVNPNCSNFLPEDQRGYPKKKTDEGGESAGSAEAAEESATDVTAAKKATAKKPAAKAKSKRTAKEPAAKKSAAGSGADKKTGVTKTAARKPAAKKTAAKKTVAKKSAAEKEN
(361) DNA topoisomerase 1 [Lactobacillus crispatus ST1]
1
MPTKAKSKTTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDDYKPKYISIRGKGDTIKELKSEAKKAKDVYLASDPDREGEAIAWHVAHALNLDEKAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWSIDAEFAKGKETFKSAFYGVDGKKKELPNIDSVKDVLAKIDKKKDFVVDKVVARQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRTSPVAQQEASKFLHENYGAEFAAKSQRHFKNQEDAQDAHEAIRPTSVYRTPESLKSVLTTEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVIFRTTGSKLKFAGFTKVYDNQQEKNVDLPDLEEGDKVKMTKSDNKQHFTLPPARYTEASLVHALEENGVGRPSTYAPTIDTIQRRYYVKLDGRSIVPTELGEIVDGLIESFFPDITDVDYTARLENELDEVEDGKKDWVHVVDEYYQPFKKELNKADSEIEKVQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIIKEIGVVCPKCGKGQVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKHSKKGPVILCPNGDYREDSENEKNN
(1776) DNA topoisomerase 1 [Caldicellulosiruptor bescii DSM 6725]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINKLKKYAQEAEKVYLATDPDREGEAISWHLATILGLDTNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRILDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDVQEFKAKFYGDKKGKIELKNQDHVQKIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRVSEEAQQAARSLIVQKFGKEYLPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSVYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEALKPIKLESKQHFTQPPSRYTEATLIKALEENGIGRPSTYAPTIQTILERGYVAKEDRFLKPTELGRIVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVKKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPVKNCPKCGSLMFEKGKKGNKKLVCSNENCAYQEKTGEKGE
(1030) Reverse gyrase [Caldicellulosiruptor bescii DSM 6725]
6
MATGAKYYHSCINCSGINTDTRNEKGLPCEKCLKDDHLTENVFELLKGRGLLKDYQIYWNFHQNYKMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTVSLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEEFEKRFISCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAVLKSSKNIDTLLQMIGFSEDEIEKATERLRSKNRENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLDNSIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFSIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEILQTEKLRQLVSKYISKEDYSKIVNKIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKVSRKIQNDDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALRNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLDVPRIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGNEGAHEAIRPVKPISPEELKELAYEKYTQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFKINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSLTDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLLELYNDISVLLNN
(1340) DNA topoisomerase 1 [Caldicellulosiruptor kristjanssonii I77R1B]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEILKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGNLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(946) Reverse gyrase [Caldicellulosiruptor kristjanssonii I77R1B]
6
MATGAKYYHSCINCGGINTDIRNENGLPCEQCLSQEQINDIYESLKKMGTLKDYRLYWNFQQNFDMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANAVKILLFNSSMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFLIDMDKAPRFVLERVFVEYLDNHPKLKGYFKSVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWVEENGVDFKNLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLDFLPMQIYPLFENKDYGITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLQELYNDISALVND
(1306) DNA topoisomerase 1 [Caldicellulosiruptor obsidiansis OB47]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAEAAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATKLVVEKEEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQIQEIEEKIKNKEFKVVKLKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARKLIAQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMNPESIKDSLTPEQYKLYKLIYDRFLASQMESSIYDVLSAELEVEGYVFRLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEISEGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKIEWTEVVRKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKKVIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPKCGSLMFEKGRKGNKKLVCSNENCLYEEKMGEKGE
(1675) Reverse gyrase [Caldicellulosiruptor obsidiansis OB47]
6
MATGAKYYHSCINCGGINTDTRNENGLPCEQCLSQKQINDIYKSLKKMGTLKDYQLYWNFQQNLNAFKMFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANTVKILLFNSLMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRTKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLAENGIKIGTTWSNFDEEFELFKEEKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPRFRFSVDMDKAPRFVLERVFVEYLEDHPKLKEYFKNVEILQTEKLRQLVLKYISAESYNKIVQEIFSHLKITDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKESRKIQNNDFYQIDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIEDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNINLVKSQIVRRIEDRWVGFELSSKLQENFQSYNLSAGRVQSTILGWIVEREKEYAKSERTFTMLKLENGYNLEIEGEEECKRVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKEFFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIRVYQLIFNRFMSSQMKNPKVLFQKVCFKIADKEIVKDIPVKIEEEGWLHFLSMQIYPLFENKDYSVTDRRSYKKHTIQLYTQSSLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILQELYNDISELLNK
(714) DNA topoisomerase 3 [Alkaliphilus oremlandii OhILAs]
2
MYHHRIERIVNMNKKLVLAEKPSVGRDLARVLNCNKKGNGYLEGQEYIVTWALGHLVTLADPENYSDRYKSWKIEDLPILPSDLKLVVIKKTGKQFQTIKEQMHRKDVNEIIIATDAGREGELVARWIIEKAKVQKPIQRLWISSVTDNAIKDGFKKLKNGKDYEKLYQSAVARAEVDWIVGINATRALTCKYNAQLSCGRVQTPTLAIIAQREAEIQNFKSRTFYGMEAMSPHLKLTWQDRKTKDIRSFEKEKITSILNAIKNKDGYVMDVEKKYKKSYAPKLYDLTELQRDANRIFGYSAKETLGIMQQLYENYKILTYPRTDSRYITSDIVPTLKDRIKACGVGPYKLAANKVLQGSIKGNSSFVDDGKVSDHHAIIPTEQFVQLSSLSDKERKVYDLVVKRFLAVLYPPFEYEETFIRAKIGEEVFIAKGKNVIHQGWKEVYGNMDEDESGNEDISEQLLPRVNKGDVLKISSITQTTGQTKPPAPFNEGTLLSAMENPVKYMKDAHKDLIKTIGETGGLGTVATRADIIEKLFSTFLIEKRGNDIWITSKGKQLLELVPEDLKSPALTADWEQKLGAISKGDLHRDHFVKEMKAYTKTVVDEIKNSDETFKHDNLTRNKCPECGKYMLEVKGKRGKMLVCQSRECGYRKGVTQNTNARCPNCHKKLELRGEGEGQIFVCSCGHREKLATFKERKKQEGSKVSKKEVVKYMNQQKKENDGFANTALADALSKLKF
(1871) DNA topoisomerase [Alkaliphilus oremlandii OhILAs]
7
MKRLVIAEKPSVAKDIAKVLNCKEKREGYIEGSDYIITWAIGHLVILCDPEEYDIRYKKWDFNTLPIIPDKIKLKPNPKTYKQYQIVKALMLSSQIDEIICATDAGREGELIFRYIYELAKCRKPFQRLWISSLTDEGIRTGFEHLKDGKAYDALYYSAKCRSESDWLVGINGSRAYSIQYGSLLPIGRVQTPTLKIIVDRDLEIDDFVPKDYWEVKADFGNYSGIWIDLEKNESKIDSIQKAEDIKNKVLLKEGLVTDFQKKKVVKKPPFLYDLTELQRDSNKKFGYTAQRTLDIAQSLYEKRKAITYPRTDSRFLTKDIIPKLKSLINKIGLEGYKEFTSILEKLEKLPVNPRIINDRKVTDHHAIIPTEKKIDLNKFSEEEKNLYDLIARRFLAVFYPDYEYFSIVMITHVAGEDFKSNEQQTIHLGWKLLYSDKEVETKESTLIHIKKGSSSTLKSAEIEQKQTKPPARYNEALLLDSMENAGKFIEDEELKEQLKSSGIGTPATRASIIERIISVGYVERKGKNLISTEKGRKLIQITSQELSSPELTGKWEKALDKIAKGNMNPQRFMEGIGRFTKFIIEDVQKNTKNVVFEGYSKNRGKKSSGTSSYNSPIGICPACKVGKVLEGPKNFYCSEYKQGCKFGIFKEDILMKKFKKKMTKTMVSKLITNQVVTVKGMVSPKTNGKFDGNICLKQSSNGYWGWEFTNGGVNN
(857) DNA topoisomerase 1 [Alkaliphilus oremlandii OhILAs]
1
MTKSLVIVESPAKAKTIEKFLGKNYVVKASVGHIIDLPKSKLGVDIDNNFEPQYITIRGKGPVLKEIKTLAKKSKNVYLATDPDREGEAISWHLARALGIEASDDCRIEFNEITKNAIKSAIKKPRPINQDLVDAQQARRVLDRLVGYQISPLLWKNVRKGLSAGRVQSVATKLIIDREEEIKNFKPEEYWTLSLKIKTKNNENFEIKFQNDNLGNKEIHTEAEVDRILNHIQNHEAIVTSVKKGEKKRNPNLPFTTSTLQQEAANKLGFSTKKTMSLAQQLYEGIDIGKSGTVGLISYIRTDSTRISQESSESCKNYIHENIGESYYHSETKERKENKGKKNIQDAHEGIRPTDVYRHPDLIKGFLSKDQYTLYKLIWQRFVASQMAPAVYDTLNVEFDINKVIFKATGSILRFEGFLKVYSYANVSENINIPDLAEGEVVTVLEQMPKQHFTQPPGRYSEATLVKTMEDLGIGRPSTYSPTISTILSRGYVEKEGKSLTATELGYIINEILEDYFSKIIDTNFTAKLEQSLDYIEEGTQDWKKLISEFYEDFKVMLLNAEEHMEEINLVEESDEKCSKCDSVMLIKHGRYGKFLACSNYPECEETKPFLYKIGVSCPKCESGDVIEKRSKKGRLFYGCSTFPDCRFVSWNRPTGKKCPTCGDILVYKKTKKSEKNICINKECGFEEEIEN
(969) DNA topoisomerase [Coprothermobacter proteolyticus DSM 5265]
7
MSILIVTEKPSVARQIAAALGKPKKEGNHLVVGEYVIAHAMGHLLQFAYPEHYGERYKKWRLEDLPIMPKEDEWQLVPISKTAVKQLEEIKTLWAKADMVISATDAGREGELIFRLIQQYVGIEKPIKRLWLQSLTKETIREQIKQLLDLSELDNLYASALARAKADWLVGINASRAFTVVSKKEVFSIGRVQTPTLAILVDREKEIQSFVPRIYYKVKVRFEVEGKSFWAESVKEYDQEEAEKLAEELIGKTLIVTEQTEEQAKINPPLLPDLGDLQKFTSRSFKWSAQKTLKILQKLYENALITYPRTDSRYLPTDMKKQVIGTANQLEPLFAKGNWEYVKKLNNRGRIFNNARVTDHFAIIPTGKIKELKGDDEKMFNYVVDRFLAAFYPPALETHQKTVFSYGNHLFEYAAVRVDDPSWYTILGGKESQELLPKIAEVMVLETSAEKRQTRPAPRFTDGMLIAAMETAGKLVESEELAEILKEKGIGTPATRAEIIERLIEMGYVQRNGPQLIPTSKGIMLIDALREVKLQSLTEPELTGEWERRLGLIEKGKETPESFMWSIEEYVKDVVQTLSKEESSKTLKSKQNMPIAKCPFCDGYILEGQKSYYCSNWKEGCKFRVWKNMNGGVITADDVRRLVAEGRTRLKRFRSKAGKAYRAFVVLKDGEVVIEFPTRKKKDGE
(136) DNA topoisomerase 1 [Thermoanaerobacter brockii subsp. finnii Ako-1]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKGYANPEANYVSKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVEEFYKDFYKTLKIAEEQMEEIEVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPDCDFILWDKPVEEKCPVCGSMLIEKNTKNVHILKCSNPGCDYQKEVK
(665) DNA topoisomerase 1 [Thermoanaerobacter wiegelii Rt8.B1]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYSNPEANYASKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFLASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQERTKLFLEELKPMQHFTQPPPRYTEASLIKELEERGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVQEFYKDFYKTLKIAEEQMEEIDVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRNYYACENAPDCDFILWDKPVNEKCPVCGSLLVEKNTKNGHILKCSNPGCDYQKEVK
(1161) DNA topoisomerase 1 [Thermoanaerobacter italicus Ab9]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFTPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNFTKFEAKFYGTKEDKVELKTKEDVDKVLAALSEEYTVDKIKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYANPRANYASKKANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDIQEEEEKTVPVLQEGTKLLLEELKPIQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDNKNLKPTELGFIVTDALKEFFTKIVDVKFTAEMEEQLDKIEEGQAKWYEVVQEFYNDFYKTLKIAEEQMEEIDIKEEVEVTDIKCELCGRPMVVKKGRYGKFLACSGFPECKNTKPLYEKIGVKCPKCGGEVVRKKSKKGRMYYACENAPNCDFILWDKPVEEKCPVCGSMLIEKNTKNIHILKCSNPECDYHKEVK
(1433) DNA topoisomerase 1 [Finegoldia magna ATCC 29328]
1
MANKKLVVVESPTKAKTIQKMLGSGYKVVATIGHLRDLPKSKLGIDIENDFEPRYINVRGKANVINALKKDYKNSQKIFLATDPDREGEAISWHLCYLLGINPKEENRVKFQEITKDSVKEAIKKPEAIDLKLVDAQQARRVLDRIVGYSISPLLWKKVKSGLSAGRVQSVALRLICEREKEIREFEPEEYWSIHANLSKDKLDFDSELYYSKSDKSNKINIKNKDEADKILNDLSDKFVVDSIKQQKKARKPYAPFTTSTLQQEAYKKLYFQTSKTMRIAQQLYEGISLGSEGSVGLITYMRTDSTRISQVCVNDCLDIINELYGKQYATRGYDYSKKKKGSQDAHEGIRPSSVKRRPNEIKKYLTEDQYKLYKLIWERTVASQMKDARYLSTSIDFDNNGYTFRSNGNVVIFDGFTRVYSLNTKDSELPELKDREAISSNEIEPKQHFTKPKPRYTEASLVKTLEEDGIGRPSTYASIISSILSRNYVELKEKKFYTTEIGEKVCEFVVKYFDSIINEKFTAEMENELDNIAENDVEWKKVIRDFYNGFNEDLVNAKNAQDKFKVKDEPIGRKCPECGNDLVIKHGRNGKFIGCSAFPECKYTETIVKDTKVKCPKCGHRIIEKVSKRGKVFYGCENYPNCDFALWDKPTGEKCPECGSLLVHRKNRRGESVLCSNEKCNYKKLEK
(1145) DNA topoisomerase [Finegoldia magna ATCC 29328]
7
MKLVIAEKPSVAVTIAKVIGARTRKNGYYEGNGYIVSWCVGHLIQMASPERHDEKWKKWTIENLPIIPEEYIYEVSKSTKKQYGVLKKLLNDKNIDTVINACDAGREGELIFRLVYNQAKCKKKIQRLWISSMENKAIEDGFRNLKDGEKFEDLYGSASARAIADWLVGMNLSRLYSCIYKETYSVGRVQTPTLYLIAKRDSEINLFKKQKYYTVDLSYKGLKLVSDRIDKIEVAEQLLNLIEDEIVITEVEDKEISTKPDKPYDLTTLQREANKYFGYSANDTLNMAQGLYEKKLITYPRTDSRYLTDDMVTTMKELLEGLEEGFKINESNFKSIFNSSKVTDHYAIIPTISGIGKVKDLSDKESKVYNLIKDKLLASCSDNLKESSRKIRYEYDKFNFNASGKTIIDEGYTKYLKAYGKEKQENELPDVKTGDKIKLTSKNISEKFTKAPSHYNEDTLLKAMENAGIESLDKDIEVERKGLGTPATRAGIIENLIHKDLIRRDKKNLLVTEKGNRLVSIVEDKFKSAKTTSEWEMKLAKISSGEVDKEDFLREIEDSIRELVDRYKNNLNE
(765) DNA topoisomerase 1 [Pelotomaculum thermopropionicum SI]
1
MSKTLVIVESPAKAKTISKFLGKKFTVKASMGHVRDLPKSQFGVDVKNGFKPKYITIRGKGDIIKDLRAAVKKADQVLIASDPDREGEAIAWHLQNLLEIDENESCRIEFNEITKQAIQKALQHPRPIDRNRVNAQQARRILDRLVGYNLSPLLWRKIKKGLSAGRVQSVAVRLICDREEEIQSFVPEEYWTLVASFVKTGEAPFEGRLIKFRDEKIDIPSKEKMQEVLENLKGARYTVEKVTRKEKSRKPPLPFITSTLQQEAYRKLNFTARKTMMVAQQLYEGLDLGREGTSGLITYIRTDSTRVSASAREEAQKYIVERFGARYAGRETPPVGPAGRKGKIQDAHEAIRPTSVQREPEQVKEYLTGDQYKLYKLIWSRFLASQMKPAVFDTTNIDIKAGEYLFRANGSVMKFPGFMKVYTESRDDEEKEEEKLLPELKEGEEIEARSLTPRQHFTQPPPRYTDASLVRALEEKGIGRPSTYAPIVETILKRGYVVRENKQFFPTELGMIVVDLLKKHFKEIIDIDFTAGMEESLDSIEEGELDWIKVLESFYGPFKNTLEKAENEIGHVQVAEEVTEEKCDRCGRSMVVKVGRYGKFLACPGFPECRSTKPLLEPVGAKCPRCEGELVVRRTKKGRKFLGCSNFPECEFVTWDQPSGTKCPECGGLMVEKKNAGKKGFLQCVSEDCGYKKTAGEKKAGKKNADTESMSAET
(1134) DNA topoisomerase 1 [Ruminococcus champanellensis 18P13 = JCM 17042]
1
MSNLVIVESPAKAKTIQKYLGGDYDVIASMGHVRDLPKSKFGVDVEHDFAPQYMDMKGKEDVIKDLKKHAKKADKIYLATDPDREGEAISWHLAQMLNLNMEDNNRVAFNEITQAGVRNGMSHPHKIDVDLVNAQQARRILDRIVGYQLSPFLWKKVKRGLSAGRVQSVAVRLVVDRENEIRAFKTQEYWSIDAKLTAPSSRKVFAAKLATIDGQKAELATKEQTDGILQTLEQAQFTVAGVKKRVTNKQPAPPFITSTLQQDASRRLGFQAKRTMKAAQELYEGVEIEGMGAVGLITYMRTDSLRISDEAKAAAAAYIEQTYGKQYLPPTPRVFKSKKNAQDAHEAIRPSMPDLTPERVKNSLTTDQFKLYKLIWERFIASQMANAQLNTVSADITAGNCGFKASGYSVKFEGFTVLYEESKDADAEDNKVLPPLEQGDLLKVKSLDGNQHFTQPPARYSEATLIKALEENGIGRPSTYAPTITTILSRLYVERDGKQLRPTALGEVITELMKEHFKHIVDAKFTAKMETDLDRVEHGDCDWVSMLHGFYDDFEKTLSKAEVAMEGKRVKVPDEETDVVCELCGKKMVIKIGRFGKFLACPGFPECRNTKKIVQETKGTCPLCGKKIVLKKSKKGRSFYGCDNYPNCNFMTWSTPVEDTCPKCGCTLFKKGGRSGKLVCEKPGCGFERSLKE
(265) DNA topoisomerase [Ruminococcus champanellensis 18P13 = JCM 17042]
7
MSILIVGEKPSVSRAISAVVGASSAHKGYTEGNGYIVSWCVGHLVGLKFPNDYGNGWNQKWSFSQLPMIPDNWLFQIMDSTKAQYNLLKNLMNKDEVTEIICATDADREGECIFRYVYNMARCRKPVKRLWVSSLEESAIRKALSIMKTMSAYDNLFNAGYARARADWLVGMNGSRLFSVRYGGKLNIGRVQTPTLAMIVQRDAEVNGFIKQKYYTSDLNCGGFILSSARIDDENAADTLVSACDGSTVTISSVKREVKTDKAPKLYDLTTLQREANKGFGYTAQQTLDYTQSLYEGKLVTYPRTDSQYLSDDMAQTALDVAKLCDTYFGFGIFHTPDIAKVINNSKVSGHHAIIPTSGISTADLSSLPTGEKNILTLIATKLICATAPAHKYEAVKLTGICNGTEFTATGRTILDMGWKAYAKQTDKKNDEKSLPAVRSVLPFQRTMCQL
(1390) DNA topoisomerase 1 [Ethanoligenens harbinense YUAN-3]
1
MSNLVIVESPAKAHTIKKYLGRGYTVVASMGHVRDLPKSRMGVDIENSFTPKYIPIRGKAPLIKSLKKEARNSTKIFLATDPDREGEAISWHLANLLGLDEKTALRVTFNEITKTAVKDGIKNPRSIDLDLVNAYQARRILDRIVGYQLSPFLWKKIRPGLSAGRVQSVAVRLIVDREDEIRAFVPEEYWTIDASELLAPGSKKPFPAHFHGGLDGKKVEIKSKEEADAILRALGATETPEGIQVSGEVPFVVRTVKKSERKKSPAPPFTTSTLQQEASRRLGFQARRTMRAAQELYEGVDVKGYGAIGLITYMRTDSLRIAAEAQQAALAYVGETFGREYLPEKPRFYKSRANAQDAHEAIRPTMPELSPDQVKESLTADQYKLYKLIWERFIASQMANKVLDTVGVDITAGDCLFKASGNTVKFKGFSIVYEMTTDENKESGKPLPVLNEGDELQVQKLDGNQHFTQPPPRYTEASLIKTLEENGIGRPSTYATTITTILARLYVERDGKQLVPTPLGEVTTKLMREHFADIVDVEFTAKMENDLDKVETGEENWVQMLTDFYGGFDHTLKKAEEELGDVHMKVPDEETDIVCELCGRKMVIKNGRYGKFLACPGYPECKNTKPIVQETGAFCPLCGGRVLAKKSKSGKKYFGCEHNPTCGFMTWDTPLEEKCPQCGGSLFKKRGGQVYCAKEGCGYTREEKK
(364) DNA topoisomerase III [Ethanoligenens harbinense YUAN-3]
7
MRFVISEKPSVAQSIAAVIGAKQRGDGFLEGNGYLVSWCLGHLAELASADAYDEKYAKWRREDLPILPENWRFTVSGDKQKQFAILRTLMRRDDVDEVINACDAGREGELIFRTVYDMAGCSKPMKRLWISSMEDEAIRQGFADLKPGRDYDGLHQSALCRSKADWLVGINATRLFSALYHRTLNVGRVMSPTLALLVQREAEISAFQPEPFYTVSLDCGTFTAIGDKLKTKSEAEAVAAACKGKTATVRAVERKEKSEKPPALYDLTTLQRDANRLLGYTAQQTLDYLQSLYEKKLCTYPRTDSRFLTNDMKASVPAFASVAAAICGTDVPESLNAGQVCDSAKVSDHHAVVPTSGAGKADVSALPAGEREILRLVSRQLLCAVGSPHQYAETAVTLDCTGYGFAAKGKTVLVPGWKSCFQEQADKPLPELAEGQDIAVASVSVKEGKTSPPKHYTEDTLLSAMETAGAKDMPDDAERKGLGTPATRAAILEKLVTTGFVERKKAKKTVNLIPSQVGVSLVTVLPEQLQSPLLTAEWENRLKQVEHGKLEPDAFMNGISSMLRELIKTYTPVKGAEVLFPSGREAVGKCPRCGGSVTESKKGFFCENDGCRFGLWKDNRFFAAKKKVLTKAVAAAFLKDGRVRLTGCYSEKTGKTYDATVILEDTGGRVNFKLEFDSGTKKRGGS
(1262) DNA topoisomerase 1 [Candidatus Desulforudis audaxviator MP104C]
1
MEKTLVIVESPAKARTLGKFLGKKYEIRASMGHVRDLPRSQFGVDVDDGFKPKYITIRGKGDAIKELRAARKKSNQVLLASDPDREGEAIAWHLQELLQIDPEEPCRVEFNEITREAVTAAIKNPRKIDPNRVDAQQARRILDRLVGYNLSPLLWRKVRKGLSAGRVQSVAVHLICAREREIEAFVSEEYWTLTALLANRERERFKARLLKKAGEKLTVPNEEAMKGILDDLKEEVYRVADVIRKEKKKNPSPPFTTSTLQQEAYRRLNFTTRKTMMVAQQLYEGLDLGKEGPVGLVTYIRTDSTRISPGAQDEAREYIAEHYGKEYVPKQKRVYTGKARAQDAHEAIRPTSVLRTPEALRKYLNPDQLRLYELIWSRFLASQMVSAVLDTVRAEIVAGEYLFRATGSTVKFPGFTRVYTELRDEAKNGEEEEEGALPALEKGEQLKLVRTTPARHFTQPPARYTEATLVRTLEELGIGRPSTYAPVVETIQRRGYVVRRGKTLHPTQLGLVVIDLLKEHFPDVINYEFTAELEEKLDRIEEGSMQWEKVLEEFYRPFRREVAEAEAKIDRVRLDEVTDEECRKCGRKMVIKMGRYGKFLACPGFPECRHTRPIFEETGHRCPKCGGRVVVRRTKKSKVFYGCAGYPGCDFVTWDQPTDQKCPDCQSFLVARGTRGHPLQRVSGSAGQSRTFACANPECGYKERKAGRGKA
(190) DNA topoisomerase 3 [Desulfotomaculum ruminis DSM 2154]
2
MNKTLVLAEKPSVARDLARVLNCGKKGNGYFEGDQYIVTWALGHLVTLADPEAYDQKYHSWRLEDLPILPSYLKLVVIKQSSRQFYTVTAQMNRKDVAEIVIATDAGREGELVARWIIEKAQVKKAIKRLWISSVTDKAIRDGFRSLKKGQAYEHLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAIIAKREEEIKNFKPKNFYGITAVSNGLKLTWQDSRSKDTKTFDADYCDKILLAIKNKPAEIIEVEKAHKKSFPPQLYDLTELQRDANRLFGYSAKETLSHMQRLYEHHKVLTYPRTDSRYLSTDMVETLKDRVEACRDNPYTKMAFKILKNPIQISKSFVDNSKVSDHHAIIPTEQPLCLSALNDKERKIYDLVVRRFLAVLYPPFEYEQTTLKAKIGQELFIAKGKRVLAQGWKEVYDNQFEDEDQPEGLAEQRLPGINKGDRLKISSISQTKGETKPPEPFNEGSLLSAMENPTKYMANQDKELIKTIGKTGGLGTVATRADIIEKLFNSFLIEKKGKHIFITSKGRQLLELVPGDLKAPDLTAEWEQKLEAIAKGVLNKNHFIDEMKQYAKLLVHEVKNSENKFRHDNLTGNKCPQCGKRMLEVNGKKGKMLVCQDRECGYRKGLSKITNARCPNCHKRMELHGEGEGQIFVCPCGYREKLTAFNERRGKEKTGSLSKKELSQYLQNQKKDEKDGLMNTALADALAKLKQP
(893) DNA topoisomerase [Desulfotomaculum ruminis DSM 2154]
7
MKTLIVTEKPSVAKDIAAVLGRFERKDGYLENREHIISWAFGHLVELADPSVYNPAFKKWQLATLPILPDSFQLVEIAGSVKQLRILKRLLHLPEVSQVVNGCDAGREGESIFRRIYRYSECRKPIKRLWLSETTPAAVKAAFNQLRDGRDYDNLAAAAEARGQADWLVGINGTRAFTLRQGTVLSVGRVQTPTLNLMVVREREIKNFKPSPYWEIWAIFQADQGSYRGKWFRGKEDRLENSEVAQALIRQLTGEGLPVQGRVTSLEQKEVKERPPFLFNLNDLQKEGNRKYGFTAQQILDLAQALYEKHKLLTYPRTDSRHLSKAMLGTLPERLAALKKAPSYAPFVPEPLPELSKRYVDDGKITDHHAIIPTAADPTKASLREAEQKIYDLVARRFLSIFYPEARYAVTEVVTEAGREKFKARGRMELAAGWKILWRDNRNPEKNHDPKGEENEDQSLPPLTREEVVEMTHIESQEKQTKPPKRYTEATLLTAMESAGKLVDNKDMAEVLKQAGGIGTPATRAAIIERLIQVGYIRREKKNLLPTDKGETLIDLAPEQLKSVELTADWEEGLRRMEEGRQEPEEWIKGIKEYTRQLVQFARNQEDAGVAEGKKSLGICPVCRRDVTETPRSYGCTGYKEGCKFAIWKEIAGKKITLKQAEDLLTKGKTGVLKGFKGKSGKPFEAALVIGEGGRVEFAFPDRAQNRSGTNPSMGPAILGPCPVCGKGVVESSKGFGCTGYKEGCKFVIWKEIAQKKIGLTLAKELLTQGRTGMLEGFKSKSGKNFEAVLVLNQGKVEFEFTKR
(1510) DNA topoisomerase 1 [Desulfotomaculum ruminis DSM 2154]
1
MSKTLVIVESPAKAKSIGKYLGRNFTVKASMGHVRDLPKSQFGVDIDQEFSPKYITIRGKGDIIKELRSAVKKSDRILLASDPDREGEAIAWHLTKLLDIDEQSPCRIEFNEITKNAIQQAVKNPRPIDQDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREDEIQAFIPEEYWTLMGKFVKSGKSPFEAKLHKYKNKKIEIPNQEMMDKILGDLKGASYQVATVSKKEKQRNPAAPFTTSSLQQEASRKLNFTSRKTMVVAQQLYEGLDLGKEGPAGLVTYIRTDSTRVSETASEEAKKFILDRFGPAYVPKQPRQTVAKGKVQDAHEAIRPTSIERDPENIKQYLTNDQYKLYKLIWSRFLASQMASAVMDTTSLDIAAGDYVFRATGSVIKFPGFMQVYIEGNDDGSKEEERLLPELSEGDKVEAKNLTPKQHFTQPPPRYTDATLVKILEEKGIGRPSTYAPIVDTIQKRGYVVRENKQFYPTELGIVVIDLLKNYFPDIINIEFTAEMEEKLDKVAEGDERWVGILKDFYQPFQETLENADEKIGKVQVADEVTDEKCELCGRNMVIKLGRYGKFLACPGFPDCRNTKPLLEPTGVGCPKCSGEMVLRRSKKGRKFYGCSRYPECDFVTWDVPTQEKCPQCGGMMVEKNSRGKEKRTECINEKCPGKEYKASEQTKKEAGAVSGKTAAKAGKKTPQRNRKKANPSG
(770) DNA topoisomerase 1 [Butyrivibrio fibrisolvens 16/4]
1
MAKNLVIVESPAKVHTIKKFLGSSYEVMASQGHVRDMPKSQLGFDPENDFEPKYITIRGKGELLAALRKEVKKADKIYLATDPDREGEAISWHLTHALNLQDKKVYRITFNEITKTAVKNSLKNPREIDMDLVDAQQARRMLDRMVGYEISPLLWAKVKRGLSAGRVQSVALRIICDREKEIEQFIPQEYYTLDVLLDAAGSKKPIVAKYYGDTSGKKDISDKESLDKIMESLKGASFNIASIKRGTREKKAPLPFTTSTMQQEASKALNFSIQKTMSVAQQLYEGVTVKGYGTVGLITYLRTDSTRVSDEAKAAAESFISSNYGDNYLSESAGNAKKNSGKVQDAHEAIRPANIELIPSEIKDSLTRDQFRLYQLVWKRFVASQMANAVYDTVSLSVSAKDQVFTASESSINFDGFMMIYTAADDEEESKTHPLAKLTEDTKLSFNSFEEKQHFTQPSPHFTEASLVKTLEELGIGRPSTYSPTITTLIKRHYITKEAKNLFVTELGEVVNSIMVDSFPIIVDDKFTANLELLLDGVEEGTVDWKSVVRNFYPDLEKAVKVAEEELAKVEIHDEVTDVICEECGRNMVIKFGPHGKFLACPGFPECRNTKPFLEKIGVPCPKCGGDVVIRKSQKGRKFYGCSNHPECDFISWSKPTTVKCPKCGTYMVEKGNKLVCGNDECRFVQSQN
(189) DNA topoisomerase III, bacteria and conjugative plasmid [Ruminococcus obeum A2-162]
7
MKLVIAEKPSVAMSLAAVLGATERKDGYLEGSGYLVSWCVGHLLELAQPEAYKEQYAKWRYEDLPILPENWKYEVPKDKKTQLALLCRLMKDKRVDSVVCATDAGREGELIFRLVYEYAGCKKPMERLWISSMEDAAIREGFDHLHPGSDYDKLYDAAVCRAGADWLIGINATRLFSVLYGVTLNVGRVMSPTLALLVQRESDIESFISKPFYVPEITCGGFTASGEKMTERSEAEKIRMDCDHNSAFVRSVEKQVKTIQPPRLYDLTTLQRECNRIYGYTAQQTLDYVQSLYEKKLATYPRTDSQYLTKDMQATAASLILWLRDNMTFGKGYAGEPDIDRVTDDSKVTDHHAIIPTVEIARTDLSELPSGERDVLTLLAVRLLCATTQVHRFEAVTAILDCQGYTFTAKGKTILQSGWKEVERIHRMSIRQSETERRENEDAALPVLKEGQTFETVSASLREGKTSPPKHYTEDTLLSAMETAGAEDMPEDAERKGLGTPATRAATLEKLVSAGFVQRKKKQLIPTEKGKNLIAVLPDNIKSPILTAEWESMLKQVEHGELSATSFMDQIADMSRTLVKEHTTPEERFADLFPSSKGTAHEAVGVCPRCGAPVFEGKKGFFCGNRECSFALWKDNRFFSSKKKSITKSVAAALLKEGRISMSGLYSEKTGRTYDAEVILDDTGGKYVNFKLEFPVKKGRRK
(658) DNA topoisomerase [Ruminococcus obeum A2-162]
7
MSKFLVIAEKPSVAQSYAKNLSAYKKEDGYLEGESCIVSWCLGHLAEYAQPEEYDPKYEKWQFDDLPILPQVWKLKVSRDKKKQFDVLKSLMNRADVDYLVNGCDAGREGELIFQRVYDLAGCRKPVKRLWISSMEDTAIRTGFQTMKGAEEYRNICMAAVCRAQADWLIGMNGTRAYTTCYFKRLVVGRVQTPTLAMLAERQDKIEHFQKEAFYKVALTDGRLTVVSENIANEEAADLLASLCMGSEAVITQVKKEQKKAFPPKLYDLTSLQREANRYFGYTAKKTLDMLQELYEEKLVTYPRTDSQFVTEDMRDTVEELVGKMPVLLPFLDYGQLGHNITRVINNAKVSDHHAILPTKEAVEKGISDLPADKKNLMMLVCQQLVQATGEEYQYEQTDITVKCQEHDFTARGKVPVQMGFKEAGNAFKNQCVKAKPEEETEKETSIPYSYEEGMTLSPVKAEKTVHFTSPPKPFNEDTLLAAMETAGNKDFDSETEKKGLGTPATKAGIIEKLVSSGYAVRKGKQILPSTEGRELVNVMPAYLKSAAMTAEWENQLLMMEKGQITDTQFMGEITSLVGKILSVCREIPEVERRRFQKAREVIGKCPVCGSDVYEGKQNFYCSNRQCDFALWKENRFLGSMEKTLDKKMAVELLDKACTHVKGLYSRKKDIKFDADLLLTLEDGKPRFHLEFPKKKKK
(1000) DNA topoisomerase [Ruminococcus obeum A2-162]
7
MAKFLVIAEKPSVAQSLAKNLSAYQRKDGYLEGNSCIVSWCLGHLAEYAPPEIYDEKYAKWQFEDLPIIPKVWKVQVSEDKKKQFDVLCNLINRADVAYLVNGCDAGREGELIFKRVYDLAGCQKPVKRLWISSMEDEAIQKGFQSLTDGREYAGLCNAAVCRAQADWLIGMNATRAYTTRYFKRLVVGRVQTPTLAMLTERKEKIEHFKKEAYYKVSLSDGKLMVTSESIPLEMEAEELRKLCDGTEALVTRVKREQKKTFPPKLYDLTSLQREANRFFGYTAQKTLDMLQELYEEKMVTYPRTDSQYVTEDMKETVKMLAEGMTGFLPFLESGQTRGNIDRVVNNAKVSDHHAILPTKEAMEKGMGGLSSGKKNLLMLIGQQLVQATGEEYLYEQTEISVQCKEHEFAAKGKLSVQMGFKEVEEAFRKYCVKDKKSDEPDNKTELSEGYEEGMILASVKAEKSTHYTSPPKMFTEDTLLAAMETAGNKEFDSETEKKGLGTPATRANIIEKLVSSGYAERKGKQILPTVAGCELIHVMPENLKSASLTAEWENLLLMMEKGKIQEDEFMNGIVSMINEILSLCRAIPEEERNRFQTAREVIGKCPVCGSDVYEGKTNYYCSDRSCQFALWKSNRFLESMKKSMDKKMAVELLKKGRTHVKGLYSKKKDSKFDADLVLGVEEGKARFSLEFPKKKK
(1705) DNA topoisomerase [Ruminococcus obeum A2-162]
7
MGKSLYIAEKPSVAQEFAKALKINGQRRDGYLESEDSVVTWCVGHLVTMSYPEKYDIKYKRWSLDTLPFLPHEFKYEVIPGVQKQFNIVKGLLNRPDVETIYVCTDSGREGEYIYRLVAQMAGVKDKNQRRVWIDSQTEEEILRGIREAKELSAYDNLADSAYLRAKEDYLMGINFSRVLTLRYGNSVSNYLNSRHQAISVGRVMTCVLGMVVRREREIRSFVKTPFYRVLSSIVLEGERFEGEWRAVDGSRYFQSPYLYKENGFKEKKHAEELIGMLQAQQPLSCRVEKVERKKENKNPPLLFNLAELQNVCSKLFKISPDETLRITQELYEKKLVTYPRTDARVLSSAVAKEIYKNISGLRRYPAIDNAAEEILQMGSYKSIAKTRYVNDKQITDHYAIIPTGQGMNALNGLSLTSQRVYETIVRRFLCVFCPPAVYQKVSLTTEMQGEKFFSSFKVLQEEGYLKYATNSFAKKSLAEKETEKNDEEDVSCDSQLLNALQALKKNDILTVDALNIKEGETSPPKRYNSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLVSIKYLSLNKKTQVITPTLLGEMIFDVVNCSIRSLLNPELTASWEKGLTYVAEGSITPQEYMDKLEHFVRVRTNQVEQSNYQYALRQFFDAAAANYTKKPTTVKRGGKA
(239) DNA topoisomerase [Ruminococcus obeum A2-162]
7
MKLVICEKPSVGAAVAAALGVREKKDGYIEGNGYVISWCIGHLVGLAEAAAYGEQYRKWSYDSLPILPQEWQYTVAADKGKQFKILKDLMQRSDVSEVVNACDAGREGELIFRFVYHQAGCKKPFTRLWISSMETDAIKSGFDNLKDGRRYDALYHSALCRAKADWLIGINATRLFSCLYGKTLNVGRVQTPTLKMLVDRDAAIMNFKKEKYYHVRLMLPGAEAASAKICAADEAGKLKAACEASAAVCTSLTRENKTAIPPKLFDLTSLQREANRIYGYTAKQTFDLAQTLYEKKLLTYPRTDSNYLTDDMGDTAASIVSLLCGKLPFMASAAYEQSISRVLNSKKVSDHHAIIPTMEIAKTDLTTLPESERNILILTGARLLMATAEPHVYEAVTAVFSCADHEFTARGKTVIAAGWKNIERLYRATLKKKPDSDDENELVLDVPDFTEGQTFENPAAKVTEHETTPPKPHNEASLLSAMERAGNEDTDPDAERRGLGTPATRAAVIEKLVKGGFVERKGKQLLPTKDGTSLVCVLPDSLTSPQLTAAWENNLTQIAKGNADPAAFMQGIEAMAQELVKTYASVLGEKQELFKTEKTELGKCPRCKSPVYEGKKNYYCSNKECSFTMWKNDRFFEERKTVFTPKIAAALLKSGKAKVKKLYSVKTGKTYDGTVLLADTGGKYVNYKVTISKDKELE
(415) DNA topoisomerase 3 [Ruminococcus obeum A2-162]
2
MKSLVIAEKPSVARDIARVLHCNQKGNGILEGKEYVVTWALGHLVTLADPEEYDKKYVKWDMETLPMMPEKMKLVVIRQTSKQYQAVKDQLFRKDIGDIIIATDAGREGELVARWILDKSGCRKPIRRLWISSVTDKAIRDGFHNLKGGREYDNLYRAAVARAEADWLVGINGTRALTCRHNAQLSCGRVQTPTLAIIARREEEIRKFQPEEYYGVTLQAGGIQWTWKDTRSGSYRTFQKDRAEDIRKNISDGVLEITSVAKKPKKTYAPGLYDLTTLQREANQKYGFSAKETLNIMQRLYENHKVLTYPRTDSRYIGKDVVPTIKERLKACGTGPYRKLAGVLISKPIQTNGGFVDDKKVSDHHAIIPTEQFVQLDHMTNEERKIYDMVVRRFLSVLYPAFEYEQTSLEAKAAGQTFAANGKTVIRAGWKAVYEEGMQEEDTEDNALKDQKLPVFRQGEKIHIDSVRLTNGKTKPPAHFTEATLLAAMENPVKYMSTKDSQAAKTLGETGGLGTVATRADIIEKLFHTFLMEKRGNEIYLTSKAKQLLELVPEDLKKPELTADWEKKLSDISKGKLKQKVFLDGIREYTEEIVGEIKTGTGTFRHDNLTNKICPNCGKRLLAVNGKNSKMLVCQDRECGYRETISRTTNARCPKCHKRMEMLVKGKEETFVCACGYKEKLSSFQARRAKEGAGVNKRDVQKYLKKQQKEAAEPVNNAFAQALAGIKLD
(1027) DNA topoisomerase 1 [Ruminococcus obeum A2-162]
1
MAKYLVIVESPAKVKTIKKFLGSNYDVQASNGHVRDFPKSQFGIDVENDFEPKYITIRGKGELLANLRKAAKKADKIYLATDPDREGEAISWHLMQALKEDPAKMRRISFNEITKTAVKASIKQPRDLDLNLVDAQQARRMLDRMVGYTISPLLWVKVKRGLSAGRVQSVALRIICDREEEINSFIPEEYWSLDGEFKIKGEKKPLQAKFYGTDKKLPIHNKAEMDKILKALENAQYEITEVKKGERTKNAPLPFTTSTLQQEAAKTLNFSTQKTMRLAQQLYEGIDIKGSGTVGLISYLRTDSTRISQEADQAAREYIEAQYGDNYVSTTGKTVKKEQKIQDAHEAIRPTDITRLPAMIKESLSRDQFRLYQLIWKRFTASRMSAAKYETTSVKIGAGEYTFTVAASKIVFDGFMSVYVQEEDNQKGNVLSQSLEKGMKLELTELKPEQHFTQPPAHYTEASLVKALEEQGIGRPSTYAPTITTIISRRYVSKEQKNLYVTELGEVVNNIMKQAFPSIVDVRFTAMMEGLLDCVEEGTVQWKTVVRNFYPDLKRDVDAAEKELEKVEIQDEVSDEVCDVCGRNMVIKYGPHGRFLACPGFPECRNTKPYYEKIGVACPKCGKDVVLKKTQKGRKYYGCIDNPECDFMSWQKPSAKKCPKCGSYMVEKGNKIVCSETTCGYVEQKSKED
(1359) DNA topoisomerase 3 [Staphylococcus aureus subsp. aureus T0131]
2
MKSLILAEKPSVARDIADALQINQKRNGYFENNQYIVTWALGHLVTNATPEQYDKNLKEWRLEDLPIIPKYMKTVVIGKTSKQFKTVKALILDNKVKDIIIATDAGREGELVARLILDKVGNKKPIRRLWISSVTKKAIQQGFKNLKDGRQYNDLYYAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVNTRQQEINQFKPQQYFTLSLTVKGFDFQLESNQRYTNKETLEQMVNNLKNVDGKIKSVATKHKKSYPQSLYNLTDLQQDMYRRYKIGPKETLNTLQSLYERHKVVTYPRTDSNYLTTDMVDTMKERIQATMATTYKDQARPLMSKTFSSKMSIFNNQKVSDHHAIIPTEVRPVMSDLSNRELKLYDMIVERFLEALMPPHEYDAITVTLEVAGHTFVLKENVTTVLGFKSIRQGESITEMQQPFSEGDEVKISKTNIREHETTPPEYFNEGSLLKAMENPQNFIQLKDKKYAQTLKQTGGIGTVATRADIIDKLFNMNAIESRDGKIKVTSKGKQILELAPEELTSPLLTAQWEEKLLLIERGKYQAKTFINEMKDFTKDVVNGIKNSDRKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPSCKTKKNVQRKTNARCPNCKKKLTLFGKGKEAVYRCVCGHSETQAHMDQRMKSKSSGKVSRKEMKKYMNKNEGLDNNPFKDALKNLNL
(1435) DNA topoisomerase 1 [Staphylococcus aureus subsp. aureus T0131]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKVEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGDITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDCPKCNQYLVENKKGKTTQVICSNCDYKEAAQK
(786) DNA topoisomerase 1 [Staphylococcus carnosus subsp. carnosus TM300]
1
MADNLVIVESPAKAKTIEKYLGKRYKVIASMGHVRDLPRSQMGVDVEEDFEPKYITIRGKGPVVKELKRHAKKAKKIFLASDPDREGEAIAWHLANILELDENAKNRVVFNEITKDAIKESFKTPRGIELNLVDAQQARRIVDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLIIDRENEIRNFKPEEYWKIEGNFRYKKSTFSAKFLHYKNKPYKLNNKDDVKFITDQLDGNEFEVTKVTKKEKKRYPANPFTTSTLQQEASRKLNFKARKTMMIAQQLYEGIDLKKQGTVGLITYTRTDSTRISAGAKAETKEFITEKYGKDYVSQRKAAAGKQGDQDAHEAIRPTKTLRTPAEMKEFLTRDQYRLYKLIWDRFVASQMAPAVLDTVAMDIEQNDVKFRANGQTIKFKGFMTLYVESKDEEEEKNSKLPVIAEGEKVVATDIEPTQHFTQPPPRFTEARLVKTLEELKIGRPSTYAPTLDTIQKRNYVKMESKRFVPTELGEIVHEQVKEYFPEIIDVDFTVNMETLLDKIADGDIKWREVVGNFYGGFEKDVERAEQEMEKIEIKDEPAGEDCEECGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKEIGVKCPKCDDGQVVERKSKKGRVFYGCSNYPECDFISWDKPVGRSCPKCDHYLVERKKGRSSQVICSNCDYKEEVQK
(1529) DNA topoisomerase 3 [Staphylococcus carnosus subsp. carnosus TM300]
2
MKSLILAEKPSVARDIANALNVTQQRNGYFENNQYIVTWALGHLVTNATPEQYDKKFKTWDLAELPIIPDHMKTVVIPKTKKQFNTVKSLMLKENVKEIIIATDAGREGELVARLILDKVHNKKPIKRLWISSITAKAIRNGFKQLKDGKAYLSLYRAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVQMRQDEIKNFRPTEYYTLEAKIAGQSFKLASQHRIKDKQKLEKLVQRLKGKQAEVVDIQSKHKKQYPAKLYSLTDLQQDAYQRYHMGAKETLNTLQNLYERHKLATYPRTDSNYLTDDMVDTFKERLQALLATEYKAQVRPLVNQKFSAKMNIINNQKVSDHHAIIPTEIRPDMNVLSQREQKLYLMIAERFIENLLPPYEYDAVKVVCKIDGESFEFQDKVTVQPGFKALKSETTPSQMPTFDKDKSYTVQGFNIQAHETTPPAYFNEGTLLKAMENPQKFFDLKDSKHSQTLKQTGGIGTVATRAGIIDKLFNMNAIEARSGQIRVTSKGRQILDLAPQELTSPLLTAEWEEKLTQIEKGKYDSCAFMKEMKNFTKDIVNEIKNSEQKYKHDNLTSTECPTCGKFMIRVKTKNGQMLVCQDPSCKTKKNVQRKTNARCPNCHKKMTLFGKGKQATYRCVCGHSETQEQMDRRHKNKGKSKVSKREMKKYMGKEELDNNPFQDALKNLKL
(1430) DNA topoisomerase 1 [Alkaliphilus metalliredigens QYMF]
1
MAKSLVIVESPAKAKTIEKFLGKRNYIVKASVGHVIDLPKSKLGVDIDKDYEPQYITIRGKGPVLKEIRTEAKKAKRIYLATDPDREGEAISWHLANALNIDKNEACRIEFNEITKNAIKSAIKTPRKINHDLVDAQQARRVLDRLVGYKISPLLWQKIRRGLSAGRVQSVATKMIKDREVEINAFQPEEYWSLILQVQNMQKEKFEVKFQSDHLGNKDIKSEDEINIIINKIKDKQLMITEVKQGEKKRNPSLPFTTSTLQQEASNKLGYSTKKTMSLAQQLYEGIELGKEGSVGLVTYIRTDSTRISEEASQHVAQYITEKIGEHYLQKSTIVKKGKKSVQDAHEAIRPTDVTRSPDVMKPYLKKDQYKLYKLIWERFVASRMEPALFDTLSITLDVEGVTFKANGSRLRFEGFLKVYSLASRSEDTDLPVLNKDELTSIVEIDPKQHFTQPPPRYTEASLVRAMEEQGIGRPSTYSPTIATILSRGYVEREGRNLLPTELGILVTGILEDFFSQIIDVHFSAELENQLDEIEEGKKGWKSLIEDFYPSFEEMLKVAEEHIEEIHLVEESDEICDQCDAPMVIKHGRYGKFLACSSYPDCTFTKPIVHKIDVKCPKCEDGEIVERKSKKGRLFYGCSGFPSCRFVSWAKPINEKCPQCNEILAHKKTKKSEKITCTNSECKYERLIEDENEK
(697) DNA topoisomerase [Alkaliphilus metalliredigens QYMF]
3
MSKSLYIAEKPSVALEFAKTLNIKGNKKDGFIESNEAVVTWCIGHLVTMSYPDKYDDKYKKWVLKDLPFLPNKYKYEVIKNVKKQFDIIKTLMKRTDISTIYVCTDSGREGEYIYRLVDEMVNVKGKTKKRVWIDSQTEEEIKKGVKNAKPLDEYDNLANAAYLRAKEDYLMGINFSRLLTLSYGSALSKRLGKKYVVIAVGRVMTCVLGMVVQREREIREFVKTPYYKIISNFQLDQSMDYDGEWKAIESSNYYMSDLLYKDIGFKEVKSAEKFIRELKEDNTELTAVVETIKKKKETKNPPLLYNLAELQNELSKKLKINPDETLKVAQKLYEKKMITYPRTDARVLSNAVAKEIHSNLKGLLRVKQSCQLEPGDEGINDFIQKIVNEGLYKELQKTKYVNDKAITDHYAIIPTGEGLGSFNRLTDYEKETFLLIVRRFLAIFYPPAIFSQLSITTKIKTESFFTTSKVCIQEGYLEILNDGKKDGASSLDKEETLKKLKKGQTVKINKLEIKESETTPPKRYSSGSIILAMESAGKLIEDEELREKIKGSGIGTSATRSGILNKLQQISYIALNKKTQILTPTSLGESIYDVVDESIPSLLKPELTASWEKGLGMIANGEIQCDEYMIKLEAYIRKNTQKVLKLSNQPNLLNSRSIKSTTNKGNQDTKGKRVGRLALGKCIACETGEVLENSKAFYCSNWKQNCKFTVWKDSLKRYEQEIDEEMIKALLEKGQIDKVSIVLPQTNEKCTASLEFKDNKKGELQLKNVTPTTE
(354) DNA topoisomerase 3 [Alkaliphilus metalliredigens QYMF]
2
MKKKLVLAEKPSVGRDLARVLNCNQKGNGYLEGKEYIVTWALGHLVTLADPETYSQKYKSWKLEDLPMLPDEMKLVVIQKTGKQFNAVKSQMVRKDVGEIIIATDAGREGELVARWIIEKVGVKKTIKRLWISSVTDKAIKDGFNKLKNGREYDNLYASAVARSEADWIVGLNATRALTTKYNSQLSCGRVQTPTLTIIAKREEEIQRFQPKTFYGAQVVAGDLKLTWQDQQTNSMRVFDETKIDQVIQSIQNQEVKVVDISKRHKKSYAPRLYDLTELQRDANKIFGYSAKETLSIMQKLYETHKALTYPRTDSRYITADIVGTLKDRLQACGVGPYKAFAAKVMQSSIKANKSFVDDAQVSDHHAIIPTEQSIYLGALSDQERKIYDLVVKRFLAVLYPPFEYEERTINAKLGKEHFIAKGKMVIHQGWKAIYGHQTEVSEDEDIADQILPNLNRGDTLKVNAISKTTGKTKPPALFTEGTLLTAMENPSKFMSNEDKTLIKTIGETGGLGTVATRADIIEKLFSSFSIEKRGKDIHITSKGKQLLQLVPEDLKSPGLTAEWEQNLSAIAKGKLNKNTFVNRMKEYTKTIVKEIKNSEAAFRHDNLTANKCPDCGKYMLEVNGKKGKMLVCQDRECGHRKIVAQKSNARCPDCKKKLELRGEGEAQIFVCSCGHREKLSTFKERRKKDQDKASKGEVNQYLKQQKKEEPINTALADALAKLKLD
(521) DNA topoisomerase 1 [Streptococcus parauberis KCTC 11537]
1
MVTKTTSKAKTTSKKATSKKKTTSPKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPEYINIRGKGPLINSLKKEAKNAKQVFLASDPDREGEAISWHLSHILGLNLEDKNRVVFNEITKDAVKNAFIEPRQVDMNLVDSQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDSLFKKGTKKFQASFYGVDGKKVKLNTNEEVKDVLSRIKNDDFTVEKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMIAQNLYEGINLGSQGTQGLITYMRTDSTRISPSVQNEAATFISNRFGSKYSKHGSRIKNASGAQDAHEAIRPSNVNHTPESIAKHLNKDQLKLYTLIWNRFVASQMTAAIFDTVKVTLEQNKVTFVANGSQIKFDGYMAVYNDSDKNKMLPEMTESETVKRESSSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYYVKLAAKRFEPTELGEIVNKLIVEFFPNIVDVAFTASMEAELDQVEEGQVKWQTVIDHFYKPFSNDLVKAEDEIEKIQIKDEPAGFDCDLCGHPMVIKLGRFGKFYACSNFPDCRNTKAITKEIGVTCPICQKGQVIERKTKRNRIFYGCDRYPECDFTSWDIPVGRTCPKSGDYLVEKKIRGGGKQVVCSSETCDYKEEKVK
(446) DNA topoisomerase [Eubacterium rectale ATCC 33656]
3
MGKSLIITEKPSVAQEFAKVLRVSGRNDGYIENGEYVISWCVGHLVGLVYPESYDMKYKKWRLEDLPFLPKEYKYDVIDSVRKQYNIVHALLQREDIDRVYWAGDAGKEGQTIEENIRNFGGVREGMEELRVWIDSQTEEEILRGIKEAKPMSAYANLGKSGIMRTIEDYAMGINFSRVMSVKYGNLLNDAAGTRSYTAIAVGRVMTCVLGMVVIREREIRNFKETPFYRVIGRFTDAGVEAEWKAVEGSRYFESPLLYKENGFKEEKDALALIEELNGKQAKIKSIVKNITKKRAPLLFNLAELQAECSKKFKISPDETLQVAQDLYEKKLTTYPRTDARVLSSAVAKEIGKNIGRLKGFEPTADFVEHIMQKRLYTNIADTQYTDDSKVTDHYAIIPTGQLTELSGLTSLQRAVFELIVRRFLSIFYPPAEYENVKLVVDVDKESFFASSKVLKSEGYLQVANPPKKKSFEESNARILGKNSETADSTDENSTANGSNDEIVVNPKVMLELADKLKAGDEIACQGYNIKFGKTSPPKRYTSGSMVLAMENAGQLIEDEELREQIKGSGIGTSATRAEIIQKLVRIGYLNLNKKTQILTPESLGEMVFEVVYMTVPALLNPKMTANWEKGLDGITRGTVDFWEYRGKLESFIRKETEKMIEQNLRPEIADRISSFAGKNARGAAARRKIGVKCPVCGGEIVTTPFGYGCANYKNDKSGCNFNIGQVAGLDIPEEQVKKLIEEGITDTIRGFKSKSGKRFDACLKLNKDEQTNKVSATFDFENVKPQKVEGIVCPDCGGDIYVSPYGYRCANYNRQTEDGCHFFVGRIADKQLSQVQFLELMANGRTETIKGFKSKSGKRFNACLVLKKEPVTEGSEKMHTVVAFDFDNVEDEIIKDVVCPLCGGQIKKTSFGYGCVNYKGDEPGSCRFSVGQIAGKTITAANLKQLLNDKKTETIRGFKSKSGKRFDACLVLKEDENKKLSVQFDFDHVEPKTVKDVVCPKCGGKIQVAPFGFVCENNRRDDPESCRFMVGKVASVKIKESVLKELLTKKKTEVISGFVSKTGMKFDAPLKLTEDGDIAFDFPEKPKPIETNVLCPKCGRPLKKTQWKYECECGFNVWHTVAKVELSEEILTELFTTGKTKKKVTGFTSKAGNVFDTCLKFENDQISFDFDNPGEEEVQSTAEVHNNADAHNNADAQSNADAYNNADTQSNTDAHNNAEVQSTADDAPDETTLNEMGIPEEFLAGFDMAADSVQADDVSEAALAAAHELFGE
(451) DNA topoisomerase 1 [Eubacterium rectale ATCC 33656]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVMASNGHVRDLPKSSLGIDVDGDFEPKYITIRGKGEILAKLRKEAKKADKIYLATDPDREGEAISWHLLHALKLEGKDVSRISFNEITKNAVKESLKHPRKIDMDLVDAQQARRVLDRIVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWSLDATVDVEGEKKPITAKLYGRGDNKIAISSKEEMDKVLNEINGKDCKVQNIKKGQRSNKAPLPFTTSTLQQEASKALNFPISKTMRIAQQLYEGVDIKGQGTVGIITYLRTDSVRVSDEAEAMAKDFISKSYGDKYLSNGEGTKKSSKNIQDAHEAIRPTDINRVPSEIKESLSRDQFRLYQLIWKRFTASRMAKSEYETTTVKLSVGDYVFSFATSRLLFDGFELAYTAADDAKKEKQPVLKNPLTEESLLTVEELLPKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTISTILARRYITKESKNLYVTEIGEVVNSIMKESFPTIVDEHFTANMESLLDAVAEGKVNWKTVVENFYPDLKDAIDKAENELEKVTIHDEVTDEICPECGRNLVIKYGPHGKFLACPGFPDCRFTMPYLEKIGVNCPKCGKDVVLKKTRKGRKYYGCIDNPECDFMSWGRPVAEKCPRCGGYMIIKGNKIACADEQCGYVTDKKPEREE
(736) DNA topoisomerase [Eubacterium rectale ATCC 33656]
7
MKLVIAEKPSVAMALASVIGARTRKDGYVEGNGYLVSWCVGHLVGLCDASEYDEKYKKWRYEDLPIVPECWKHRVLEGTKKQFGILKKLMRDSKVDEVICATDAGREGELIFRLVYEQAGCKKPMKRLWISSMEEQAIKDGFASLKDGSCYDSLYQSALCRAKADWLVGINASRLFSVLYNQNLKVGRVQTPTLAMIVDRNQKIKEFTKEKYYMAHIKFDEMDAVTEHFQKKEDADRVAADCMERMCEVEKDDVKEKTVRPPKLYDLTTLQREANRMFGYTAQQTLDAVQEMYEQKLVTYPRTDSQYLTDEMGESTETLIQMLLGKMPYAEGLEYHPDVSKVLNSKKVSDHHAIIPTMEVAKADIGELKERNRKILYLISARVLTATADPYIYESHKCQITCNYHTFYLTAKKTKQEGFKAIENKLKQFFGVKIEKEEPELDIWAGKHYGPCDSLVSEHFTQPPKQYTEDTLLSAMERAGNEELTEDTEKKGLGTPATRAAIIEKLIQSGFVKREKKNLVPTDDGNVLITVLPDEIKSPKMTAEWEMALNHIAQNTETADEFLNGITELMQELVARYQGISEEKKNQFQGKAKGEVIGKCPRCGADVQEGKVNFYCSDRNCTFTLWKNDKFLASQGKKMDKTAAKKFLSKGKIHYKDLVSRKTGRQYEATVEMVDPGEGNVQFNLIFPQR
(178) DNA topoisomerase 1 [Streptococcus macedonicus ACA-DC 198]
1
MATTTTTKAQTAVKKSSKKTTKKKTAAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINNLKKEAKKSKKVYLASDPDREGEAISWHLAHILDLDENDKNRVVFNEITKDAVKNAFIEPRQIDMNLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGFFKKGTKKFQASFYGIDGKKLKLETNEDVQKVLALLTSDEFTVAKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGISLGKSGTQGLITYMRTDSTRISPIAQNDAANFITERFGEKYSKHGSRVKNASGAQDAHEAIRPSNVNLTPESIAKHLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVNLEQNNVRFTANGSQVKFDGYLAVYNDSDKNKMLPNMVEGDIVKKVSTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVRLAAKRFEPTELGEIVNNLIVEFFPDIVDVKFTADMEGKLDEVEEGKQQWQKVIDEFYKTFEKELAKAETEIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVTCPVCGKGQVIERKTKRNRIFYGCDRYPECEFTSWDKPVGRSCPKSGDFLVEKKIRGGGKQVVCSNEECDYEEAKIK
(1394) DNA topoisomerase [Streptococcus macedonicus ACA-DC 198]
3
MKYLLLAEKPDQAKKYANALGNPKNDKGVWRVQSSVLNAEVIVAPAVGHLVERINPYTNFENWEMANLPALPEGFSYEPKKDTIKRFKAIKKAVKEVDAIIIGTDPDREGEAIAYRILELIPGALRKIKYRLWANSLTKKGLEQAFSSLKNPKDSVNYFHEADARGDADWLVGFNLSPFVTIKMKEEGYLDKKDHSMSVGRVQTPIVSLIVRNDEAIENFKPSPYWQLKLIDPEAKVTFGNDIKYQSKAEAEQMLQQLANIAVVKTVTSEEKVQEAPKLYNLTNFQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFAYLVEHIEDYQKAINKQLETPNRSPRKAYVNDKKVLEHYAIIPTETIPDLSELSDDEKLIYQKVVFRTLLMFTPDYRYQSTSVILDNHGLEFKATGAVTKDKGWRNYLAVKKEDKELPNYQEGQTITVECKLLEEMTKPPTRITEQILLKKLLPKYNLGTSATRDGMIDLIQDKGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVDKIKWAITKQIEKGKQI
(1160) DNA topoisomerase 1 [Staphylococcus pseudintermedius HKU10-03]
1
MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDVEHDYEPKYITIRGKGPVVKDLKRHAKKAKKVFLASDPDREGEAIAWHLANILELEDSKENRVVFNEITKDAVKESFKHPRGIEMDLVDAQQARRVLDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYGKSKFNAKFLHYKDKPFKLATKDDVTVITKALDGNQFTVSNVTKKEKTRKPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKRKGTIGLITYMRTDSTRISKDAQNEAKQFIESEYGSAYLSKVTKKGKQGDQDAHEAIRPTSTLRTPAEMKDYLTRDQYRLYKLIWERFVASQMAPAILDTVAVDLTQNDVKFRANGQTIKFKGFMTLYVETDDDKGKEKENRLPKLEVGNEVLATKIDPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKNESKRFVPTELGEIVHEQVKEYFPEIIDVDFTVNMETLLDKIADGDVAWKKVVGDFFNSFKQDVERAEKEMEKVEIKDEPAGEDCEVCGNPMVIKMGRYGKFMACSNFPDCRNTKAITKPIGVTCPKCKKGDVVERKSKKNRIFYGCSNYPECDFVTWDKPIGRDCPKCQHYLAENKKGRATQVVCSNCDYKEEVQK
(1791) DNA topoisomerase 3 [Staphylococcus pseudintermedius HKU10-03]
2
MSKALILAEKPSVGRDIANALNVGSRKEGYFENHQYIVTWALGHLVTNATPEQYDKKYQQWVLEDLPIIPKQMKSVVISKTRKQFNTIQNLMKRSDVKELIIATDAGREGELVARLIIEKAHVKKPIKRLWISSVTPKAIKEGFKKLKDGRAYQHLYEAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVAMRQEQIKNFKPQQYYTLEAEVNGVTMTYQHDGRVYQKEKLETIVNTLQNKQAQVNSVHEKEKKVYPQPLFNLTDLQQAAYQKYHLGAKQTLNTLQQLYERHKLVTYPRTDSNYLTTDMVDTLKERVQATMGTDLMPYAREILKQPFAKKLSFVNNQKVSDHHAIIPTEVRANVASLSPNEQKIYTMIAQRYLEVLMPPYRYRAQHVEVNIGKHVFTYQSQVPIELGFKKLQQDRAQTERAVSFKQGETFDVGRLHIVAHETTPPAYFNEGTLLKAMERPDKFFDLKDKKSAQTLKSTGGIGTVATRADIIDKLFNVNAIESHDGKIKVTSKGKQILDLAPPALTSPRLTAEWEDKLMKIEKGQYKAHQFMQEMKQFTHEIIHTIKSSEQKYKHDNLTSAQCPTCGKFMLRVNTKNGSMLVCQDPSCKTKKDVKTKTNARCPQCKKRLTKFGTGKKATYRCVCGYTETQEHMDQRFKNKGKDKVSKREMKKYMKEDELENNPFKDALKGLNL
(1868) DNA topoisomerase 1 [Staphylococcus epidermidis RP62A]
1
MADNLVIVESPAKAKTIEKYLGKRYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIRGKGPVVKDLKKHAKKAKKIFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAVKDSFKHPRGIEMDLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKSKFTAKFLHYKNKPYKLNNKDDVQRITEALNGDQFEITNVNRKEKTRYPAHPFTTSTLQQEAARKLNFKARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISTSAKSEAQQYINDKYGEQYVSQRKSSGKQGDQDAHEAIRPTSTMRTPDDMKAFLTRDQHRLYKLIWERFVASQMAPAILDTVALDVTQNDIKFRANGQTIKFKGFMTLYVEAKDDKENDKENKLPQLDKGDKVTATKIEPAQHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFIPTELGEIVYEQVKEYFPEIIDVEFTVNMETLLDKIAEGDMNWRKVIGDFYNSFKQDVERAESEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKTIGVTCPKCNEGDVVERKSKKNRIFYGCSRYPECDFISWDKPVGRDCPKCHHYLVNKKKGKSSQVVCSNCDYEEEVQK
(812) DNA topoisomerase 3 [Staphylococcus epidermidis RP62A]
2
MKSLILAEKPSVGRDIANALNLQQKSNGYIEGKQYIVTWALGHLVTNATPEQYNPSYKEWNLEDLPIIPKKMKTVVISKTNRQFKIVKSLILDKNVKEIIIATDAGREGELVARLILDKVGNKKPIKRLWISSVTKKAIQEGFKQLKNGNAYQNLYEAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQIVKSRQDEINYFKPEKYYTLSINVDGYDLNLKQQKRYKDKKELELIEHKIKHQEGKILEVKGKNKKSYAQPLFNLTDLQQEAYKHYKMGPKETLNTLQHLYERHKLVTYPRTDSNYLTDDMVDTIQERLRAILATDYKSHVRDLISESFSSKMHIFNNQKVSDHHAIIPTEVRPSIEQLSQREFKIYMLIAERFLENLMNPYLYEVLTIHAQLKDYNFVLKEIIPKQLGYKALKDQTSSHTLTHSFKEGQLFKVHRIEIHEHETKAPEYFNEGSLLKAMENPQNHIDLNDKKYAKTLKHSGGIGTVATRADIIEKLFNMNALESRDGKIKVTSKGKQILELSPSELTSPILTAQWEEKLMLIEKGKYNSQKFIQEMKNFTFKVVNKIKSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPKCKTKKNIQRKTNARCPYCKKKMTLFGKGKEAVYRCVCGHTETQSQMDKRMRDKTNGKVSRKEMKKYINKKEEIDNNPFKDALKNLKL
(869) DNA topoisomerase 1 [Bacillus amyloliquefaciens LL3]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLSSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFKPEEYWTITGSFLKGKETFEAGFFGKNGKKLPLKSEEDVKAVLAELKGNKYTVDKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAVEEASAFIDQAYGKEYLAGKRKAAKKNENAQDAHEAIRPTSVLRKPAELKAVLGRDQLRLYKLIWERFVASQMAPAVLDTMSVDLSNNGLTFRANGSKVKFAGFMKVYVEGKDDQLEEKDRMLPDLKEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQIVLDLIMEFFPEIINVEFTAKMERDLDHVEDGETEWVQIIDSFYTDFEKRVKKAEAEMKEVEIEPEYADEDCELCGSRMVYKMGRYGKFMACSNFPDCRNTKPIVKQIGVKCPKCHEGNIVERKSKKKRVFYGCDRYPECDFVSWDKPIERKCPKCENMLVEKKLKKGIQVQCVECDYKEEPQK
(1431) DNA topoisomerase 3 [Bacillus amyloliquefaciens LL3]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDRYIVTWALGHLVTLADPEGYGKEYQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKAQLIRKDVSEIVIATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGLRAAADQMTLTWQDKKTKQTRTFDQTVTGRLAKDLQGKPAVISELKKTAKKSFAPGLYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSADIVPTLKDRLNGMEVKPYAQYVNQILKRGVKAHKGFVNDAKVSDHHAIIPTEEPLILSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVTADIGGETFTAKGKTVQSPGWKAVYDMYEDDDDHEEDKDQTLPALQQGQRLSVSSLKETSGQTKPPARFNEGTLLSVMENPSAFMQGEEKNLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKEKDIFITSKGKQLLQLVPEDLKSPALTAEWEQKLSSIAAGKLKSAVFIKDMKSYAGKTVKEIKNSSQTFRHDNISGTACPDCGKMMLKVNGKRGTMLVCQDRECGSRKTVARKTNARCPNCHKKMELRGQGEGQTFACVCGHREKLSVFEKRKAKDKSGRASKRDINSYMKKQNNDEPMNNALAEQLKKLGLDK
(428) DNA topoisomerase 3 [Bacillus mycoides DSM 2048]
2
MFLNMAKSIVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKQWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIIATDAGREGELVARWIIDKVKMQKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIASREDEIKHFKAQTYYGIEAQTAERLKLTWQDTKGNSRSFNKEKTDAIVNKISKQNATVVDIDKKQKKSFAPGLYDLTELQRDANKIFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPVKSNKSFVDDSKVSDHHAIIPTESYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKIGDETFIARGKTILHAGWKEVYANRFEDDDASDDVKEQILPRIEKGDTLNIKLIVQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLLEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVAEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGSKADKRDVQKYMKQQNKEEEPLNNPFAEALKKLKFD
(953) DNA topoisomerase [Bacillus mycoides DSM 2048]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLNTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTEIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDEADTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYEGKWEKDNESRLNDPDLANKIAAFCQNKPAVVKEMKTERKEFQPPFLFNLSALQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLNQFDEYKGLLPAPIESIMNNKRYVNEKKVTDHYAIIPTEQVTNPSKLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTITTLVDERAAFISKGKQQIQEGWRKVIFQDDKDDETILPIVAEGEQGKVVKVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVQKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGTASPATFMEQTKKLSAKIIEDAVEMSEKWDFTGLHVESIERKGSKFTTGKKVGNCKKCDGDVIDKSTFYGCSNYNTTQCDFTISKKILSKAISQKNMTKLLKGEKTDLIKGFKKGEKTFDAKLEWKDNKINFVFEN
(963) DNA topoisomerase 1 [Bacillus mycoides DSM 2048]
1
MGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKYPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREKEIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNEAQVNEIIEKMKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARDYITEAFGAEYIGTEKRKETKKSKAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTAKLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDIEPKQHYTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVALDNKRFVPTELGGIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCSHPMVFKMGKYGKFMACSNFPECRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(889) DNA topoisomerase 1 [Streptococcus pyogenes str. Manfredo]
1
MGTKTTTKPKTGTKKSTTKKKSTAKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKAAKKVYLASDPDREGEAISWHLSHILGLDPQDNNRVVFNEITKDAVKHAFVEPRQIDMDLVDSQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENKIKAFVPEEYWSIDGLFKKGTKKFQATFYGINGKKTKLDNNNDVKEVLAKLTNEDFLVSKVDKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIHLGENGTQGLITYMRTDSTRISPVAQNDAAQFIINRFGANYSKHGNRVKNTSGAQDAHEAIRPSSVNHTPDSIAKYLNKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLEQNGVIFVSNGSQMKFDGYMAVYNDSDKNKMLPEMAEGETVKKISTSPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVDVAFTAEMEGKLDQVEIGEEQWQHVIDQFYQPFVKELNKAESEIEKIQIKDEPAGFDCDVCGHPMVIKLGRFGKFYACSNFPECRNTKAITKEIGVTCPVCHKGQVIERKTKKNRIFYGCDQYPDCEFISWDLPIGRACPKSGDYLIEKKVRGGKQVMCSNETCDYKEEKIK
(501) DNA topoisomerase 1 [Bacillus pseudofirmus OF4]
1
MADYLVIVESPAKAKTIGKYLGKKYIVKASMGHVRDLPKSQMGVDVEENFQPKYITIRGKGPVLKELKTAAKKVKRIYLAADPDREGEAIAWHLAHSLNIDEQSDCRVVFNEITKQAIKDAFKTPRKINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIEREKEIQAFVPEEYWTIQGKFSLGDEAFDAKFYGVDGKKQELKSEEEVQAVLKQLKGKSFDVASVKKKERKRNPVTPFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISETAQNETRQYIVEQFGEEYTRVGQRAVKKDKKAQDAHEAIRPTAVFKDPKSLKSYLSRDQLRLYRLIWERLVASEMAPAIMDTMSVDLVNEGVLFRATGSKVKFPGFMKVYIEGNDDGKKEEDRLLPNLEEGQKVKKESIDPNQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQKRGYVALEEKRFVPTELGEIVLELIVEFFPEILDVEFTAKMEGDLDSIEEGNHEWVHIIDGFYQGFEKRLKVAEEEMKEVEIKDEPAGEDCEKCGHEMVYKMGRYGKFMACSNFPECRNTKAIVKDIGVKCPTCKEGNIVERKSKKRRTFYGCDRYPECEFISWDKPISRPCPKCSAMLVEKKTKKGVNVQCSSCDYKEEAN
(1642) DNA topoisomerase III [Bacillus pseudofirmus OF4]
7
MKLIIAEKPDQGAKLAAPFPMVKKQGYIEIKSCEMFPEGAFVTWAVGHLCELESPEKYDPKWKSWKLDTLPILPPTFKYKVSKGKYKQFQVVKKLIENRNVREIIMAGDAGREGELIVRLIIEQCRASHPLKRLWLSSLTRQAVIDGFNTLKPEQETRPLYDEALSRACADWLIGMNASRAYTLLLGEKGIDDVFSTGRVQTPTLALIVKREKEIEAFKPEPFWEVKAAFKMGEKTYEGVWHKKGETRVNSSRQALQIAQFCEGKPAIVQAIKEEKKEYAPPYLYNLSSLQTAANKRYKYSPKKTLDLAQKLYVKGYISYPRTDSSFVTKGEASTFPAILQKLSAFKEYESFFPLPVKSLMNNRRFVNDQKVSDHYAIIPTEQVPKQERLGAEERNIYDLIVRSLLAAHENAAIISHTQVETIVDGRATFQSKGKQMINEGWRKIIYEGKKQEDTLLPPLSHGEEGVVSKSVVKEGMTQPPKRYTEGQLITVMKAAGKSIEDKELEKVMMESHGLGTEATRAGIITVLKDRGYMMVEKNIVFPTQKGRLLIDSLGTSILASAEMTAKWEQRLREIGKGAASKNDFMEQARKLSVHLINEAVSQSRSWDFTNIDTSSIKRRGGKGSKSYTGNRQVKKTVGQCRLCQGEILDRGTFFGCSNYKSKKCMFTLSKTLLGKKLTETTVTTLLSKGETRVLKGFKKGEQTFDAALRLTPEGKITFQKKE
(931) DNA topoisomerase 3 [Bacillus pseudofirmus OF4]
2
MKKSVVLAEKPSVARDLARVLKCEKKGNGYFEGSKYIVTWALGHLVTLADPESYGDTYKSWKLEDLPMLPSKLNLVVIKKTSKQFHAVKAQLNRGDVEQVIIATDAGREGELVARWILAKAHCHKPVKRLWISSVTDKAIQEGFSQLKDGKRYEPLYDAAVARSEADWYVGLNGTRALTTKYNAQLSCGRVQTPTLAMIAKREADIQAFKPKSFDQLFITVKDSLRFQWYQKESGERRIFDDQHAKNLKEKLEGEKLTVKAVKKQKKKTLAPKLYDLTELQREANQKFGFSAKETLSTLQKLYEHHKAVTYPRTDSRYLSSDLVETLDDRLKACDVQPYRKFVSDIRKRPLKANTHFVDDRKVTDHHAIIPTEQAPAPSALSEREYKLYQLIVRRFLAVLYPAYEYEQTKIEAEACGEQFEAKGDQVLKLGWKVVYDTKEESEGLPVVKEAEEFTIKNCTLTKGETKPPARFNEGTLLSVMERPQAFMENKTEEIAETLGKTGGIGTVATRADIIEKLFQSFLIEKRGKDLFITSKGKQLLDLVPEDLRTPALTAEWEQKLEAIANGKLTKQAFISDMKQYAKSIVGSIKASDKTFRHDNITGSKCPECGKLMLEVNGKRGKMRVCQDRECGYKKNIAKVTNARCPKCKKKLELRGEGEGQTFACVCGHREKLSVFNERKKKNKHKQVSKREVSNYMKKQNKDEDFGNTALADALAKLKLDK
(1581) DNA topoisomerase 3 [Solibacillus silvestris StLB046]
2
MFTMVKSLVLAEKPSVARDIANVLKCHKKGNGFLEGDKYIVTWALGHLVTLADPESYDEKYKKWDLADLPMLPERLKLTTIKQTSKQYNAVKSQLTRNDVNEIIIATDAGREGELVARWIIERAKVNKPVKRLWISSVTDKAIKEGFANLKPGKAYENLYYAAVARSEADWYIGLNASRALSTKFNAQLNTGRVQTPVVAMVAAREDEIKNFKPQTYYGIEAQTKELKLTWQDQNGNARSFDKEKIDKIVHTLDKQNAKVIDIERKPKKTFSPGLYDLTELQRDANKLFGYSAKETLNIMQKLYESHKVLTYPRTDSRYLSSDIVSTLPERLKACSVGEYRTLANKVLTKPIKASKSFVDDSKVSDHHAIIPTEEYVNFANFNDKERKIYDLVVKRFLAVLFPAHEYEQLTVQAEIGKEKFIARGKTVISAGWKEVYSNRFDDEETSEDVKEQLLPRLEKGQVLNVTLLAQTSGQTKPPARFTEATILTAMENPAKYMNTQNKALADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPNELKSPETTAQWEQKLEQIAKGKLKKDVFINEMKQHTKAIVADIKNSDKKFKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRVTNARCPQCKKKLELHGQGEGQIFVCKCGYREKLSAFEARRKKEGGGKVDKRSVQKYLKQQEKEVEPINNAFADLLKGMKFDE
(797) DNA topoisomerase 1 [Solibacillus silvestris StLB046]
1
MADYLVIVESPAKAKTIERYLGKKYKVKASIGHVRDLPRSQMGIDTENNYDPKYITIRGKGPVLQELKTAAKKVKKIYLAADPDREGEAIAWHLATALNIDINSDCRVVFNEITKEAILESFKHPRPINMDLVDAQQARRILDRLVGYNISPILWKKVKKGLSAGRVQSVSLRLIIDRENEIKSFEPEEYWSIDASFEKNKKQFDAFYYGNGKEKVKLTNEQQVKDILKGIKGSEFEVMNVIKRERKRNASPAFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIELSKKEGAVGLITYMRTDSTRISDTAKTEAKSYIETKYGKDFIAGEQKQAKAKANAQDAHEAIRPTSAMRTPEELKAILSRDQLRLYRLIWERFIASQMSPAVLDTVTVDLQNNDVLFRANGSQVKFAGFMKLYIEGTDDQEEETNKLLPEMEIGDKVKSLEIEPKQHFTQPPPRYSEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVQLDAKRFVPTELGEIVHQATLEFFPEIINIEFTAQMEQNLDEIEEGITQWVNVIDEFYKDFEPRVKYADEVMEKIEIKDEPAGEDCEKCGAPMVFKLGRYGKFMACSNFPDCRNTKAIVKPIDVKCPSCETGEIVERKSKTKRIFYGCNQYPECDFVSWDKPISRPCPKCSALLVEKKLKKGVQIQCTNSECDYEETPSQ
(956) DNA topoisomerase [Solibacillus silvestris StLB046]
7
MKIVIAEKPDQAAKLAAPFSFTKKAGYFEVKPNTYFPEGALITWAIGHLCELKAPEEYNATWKKWTLETLPIIPERFEYKVTKTKYKQFNIIKTLVKRPDIREIIIGGDAGREGELIIRTILKVCGVNKPMKRLWISSLTENAVKNGFANLLPEEQTRNIYFEALSRSCADWLIGINTSRLYTVLLKRNGVKDVFSIGRVQTPTLALIVKREHEIANFKPEPFWEVEAEFNFNGKVLKAKWHKNSVTRLLEERQAIAAANFCINKNVEIKNIKKETKEYAPPLLFNLSALQATANRAFKFSPQMTLDILQKLYLKGVVSYPRSDSQFLTNEEAKTLPAILGQLGKLDQYKNLLPPPTTSLMNNKRFVNEKKVTDHHAIIITEQVPNMGKLSAEEAKIYDLVARQVIAAHYNNAVFSYTTIHSLVDNRAEFISKGKVLLEEGWRKVIHHSKDSADKDELLPLLQENEQGTVVKANVKKGETQPPNRYSEGNLITVMKTAGKHLEDAELEKVLSKTEGLGTEATRAGIIGTLKDRNYIEVKKNQVFATTKGMLLIEALGESILTSASMTAKWEQRLSEIGEGNASPQVFMEQVKKLADKLIVDAGEREKEWAFNQNDVEEITENNPYTKKYNKVKTVVGKCILCDGSIVDHGTFYGCSNYKKANCKFSVSKKILGKTITQTNLKKLLASGETDLIKGFKRGGKIFNAHLIWDEKERKTSFKFTNTK
(283) DNA topoisomerase [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
7
MKSLVLAEKPSVAREIARVLQCSKKSKGYIEGPRYVVTWALGHLVTLAEPDDYDKRLKQWRIEDLPMLPEKMKLKVIKQTSHQFQVVKELMKRNDIEELVIATDAGREGELVARWIMEMVRWRKPFKRLWISSQTDNAIREGFARLQPGTQYNSLYAAAACRAEADWLIGLNVTRSLSCKFNAQLNAGRVQTPTLAMIVKREKEIKAFVPRDYWTIRADFGDYYGDWRGKDGGRIFDYARAEEILSRIKGRMAAIKEVKTEARSEAPPLAYDLTELQREANRRLGWSAQKTLSILQELYEVHKLVTYPRTDSRYITDDIVPTLPLRLKSMGVGPYADLAHPLLQKPLKPGKRLVDNSKVSDHHAIIPTEQPLQLKSLNEEERRLYDLIARRFLAVLYPPYRYEQTTIITVVEGENFHSRGKVEIDRGWRAVQAVPSDKDEKDEEQLPEQTLARHKKGETLEVKSGKASKHKTKAPARYTEATLLTAMENCGKLVEDKKLRESIKGSGLGTPATRAEIIEKLIRTSYIERQRKELVPTSKGIQLMDLAPPDLRSPELTAQWEQRLAEIARGQGKRLDFMADIRRDTVQLVQNIKSDSSSTYRADNVSKSKCPQCGRFMLLVNGRKGKILACPERSCGYRQPEAEDFSGKGGNSRANRRLMAKYSNQEELETNLGELLKAALAKKEQG
(97) DNA topoisomerase 1 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
1
MAGTTLLIVESAAKARTLGKFLGKGYKIKASVGHVRDLPKSKLGVDVENDFEPQYITIRGKGDILKEIKDESQKAGRVLLATDPDREGEAIAWHLQNAMKIPPEENCRIEFHEITREAVKKAIKNSRPVDLSRVNAQQARRVLDRLVGYNLSPLLWNKIRKGLSAGRVQSVALKLICDREEEIKNFIPQEYWTVDAIFNAAKGKNSKFTARLASYQGKKIEINSDKEVAAIGEYLQGANFTVLKVERKEKRKNPNPPFITSTLQQEASRRLNFFSNRTMRVAQELYEGLEIGKEGTVGLITYLRTDSTRVASSAQMEALDFINSTFGAEFAPDKPNEYKSRKSAQDAHEAIRPTSIQRTPESVKAFLSRDQYRLYQLIWNRFVSSQMTPAVYDSLTVDISAGDYGFRASSSQLKFIGYKKVYSDNEEEEPKNNIPELKKGEELALHELKPEQHFTQPPPRFSEASLIKLLEEKSVGRPSTYAPTIDTILKRNYVERQNRQFIPTELGFIVVDLLKEHFANILDVEFTARMEGELDLVEEGKLDWKKVVRDFYEPFHSDLEKARELAQKIEIKDEEAGKECPQCGRPMLIKHGRFGKFMACSGFPECRHTQSINQELGLKCPLCQGSIVALKSKKGRTFYGCSNYPQCNFRSWDKPTGKICPHCGDAIVEKFNKKKEATQICQNPACKQKVEMGG
(420) DNA topoisomerase 1 [Syntrophothermus lipocalidus DSM 12680]
1
MLVIVESAAKAKTISKFLGRNYKVLASVGHVRDLPKSKLGVDVEHGFTPQYVTIRGKGEILKHIREESEKSSRVLLATDPDREGEAIAWHLSQAMNLKDKNPCRIEFNEITKDAVTRAVKKPRPIDMNRVNAQQARRVLDRLVGYSLSPLLWNKIKKGLSAGRVQSVALRLICEREREIESFVPEEYWTIEGEFAAGNKALVARLVARGREKLEIGSREAVDAILAELETARFTVSKVEKKTKKKNPVPPFITSTLQQEAYKKLGFTASRTMRVAQELYEGLSLGEGGTVGLVTYIRTDSSRVAEEAQKEALDFVEQTFGKEYRPEKPNVYKSKKTAQDAHEAIRPTSVWRQPERVKTFLTRDQYRLYKLIWERFLASQMAPAVYDTVTVEITGGGYVFRASASNLKFPGYLAVYQESENEEEDEKRAIPEVQEGQELVARGFKPEQHFTQPPPRYTEASLVKMLEEKNIGRPSTYAPIVDTILRRGYVERKNKQFVPTELGFIVVDLLKDYFPEIMDVEFTASMEENLDRIEEGELNWQETVEEFYVPFSDKLRKASSEIEKVELKPEEAGKDCPVCGKPMVIRNGRYGRFLACSGFPKCRYTESVNEETGITCPQCGRKVIALRTKKGRRFYGCEGYPQCDFRSWNLPTEKKCPQCGGPMVRKRGRGQEYLACTSKECRYEEKEARM
(1432) DNA topoisomerase 1 [Streptococcus equi subsp. zooepidemicus ATCC 35246]
1
MCQLVTKTATKSKQETKRSATKKKSAAAKKNLVIVESPAKAKTIEKYLGRQYKVVASVGHIRDLKKSSMSIDFDNHYEPQYINIRGKGPLINSLKKEAKNAKKVYLASDPDREGEAISWHLSHILGLDPDDNNRVVFNEITKDAVKEAFEGPRKIDMDLVDSQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDREHEIKAFVPKEYWSIDGLFKKGTKKFQASFYGLNGKKMKLNTNDDVKLVLSQLSSDDFMVSKVEKKERRRHAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGISLGPNGTQGLITYMRTDSTRISPVAQNDAAGFIVERFGSQYSKHGNRVKNATGAQDAHEAIRPSNVNHTPEAIAKFLDKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLEQNGVLFVANGSQMKFDGYMAVYNDSDKSKMLPEMAEGEVVKKVTLTPEQHFTQPPARYSEASLIKTLEENGVGRPSTYAPTLDVIQRRYYVKLAAKRFEPTELGEIVNQLIVEFFPDIVDVKFTADMEDKLDQIEIGKEAWQNVIDQFYKPFVKELTKAETEIEKIQIKDEPAGFDCELCGHPMVVKLGRFGKFYACSNFPECHHTKAITKEIGVSCPACQQGQVIERKTKRNRIFYGCDRYPECDFTSWDLPVGRSCPKSGDYLVEKKIRGGKQVVCSNEACDYKEEIVK
(1493) DNA topoisomerase 1 [Lactococcus lactis subsp. lactis IO-1]
1
MPTSTKSKTKKTTKKKTTRKRVTPGKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSTMSVDIENDYEPQYINIRGKAPLINSLKKEAKAAKAVYLASDPDREGEAISWHLAHILNLPLEEKNRVVFNEITKDAVKNAFKEPRQIDVDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIVDRENEINAFIPEEYWSIDGEFKKGTKKFKASFWGIDGKKHPLKTNEDVIKVMERLDGPDFNVDKVEKKERRRNAPLPYTTSSMQQDAANKLNFRTRKTMMVAQQLYEGLTLGSQGHQGLITYMRTDSTRISPVAQSAAHNYIADQFGEKYSKHGSKVKNASGAQDAHEAIRPSNVFNTPDAIAKYLDKDQLKLYTLIWNRFVASQMVAAIFDTVKVNLSQNGVIFIANGSQVKFDGYLRIYNDSDKSNMLPEMEENETVKKANVKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLETIQKRYYVRLSAKRFEPTELGEIVNKLIVEFFPNIVNTEFTAEMEKDLDEVEEGKRQWIEVVDQFYKPFAKELENAEEGMEKIQIKDEPAGFDCDVCGSPMVIKLGRFGKFYACSNFPDCRNTKAIVKEIGVKCPLCHEGNIIERKTKKNRIFYGCDRYPECEFTSWDKPIGRDCPKSGHFLVEKKVRGGGKQVVCSNDECDYQEEKQK
(1845) DNA topoisomerase [Lactobacillus sakei subsp. sakei 23K]
7
MRKKLVITEKPSVAKELAKVLGTNQKTKTYFEGDQYVITWAFGHLLSLQLPEDIKKEWQQWRLEDLPIIPKHIGLKPLPKTGGQLKAISHLAHRQDISGAVIATDSGREGEAVARYILEWIKFDKPVERLWISSQTTKAIKDGFANLKPAKQFDNLYASALARGHADWLIGLNVTRALTTKYEDNLSAGRVQTPTLAFVNETAQQISRFKPEKYYTIQLKVGQEQATLQMAKPQGLKDRAQAETLVAKLKQAQGKVGSVKTSQKSQAAPLPYDLTELQQVANAMYGLSAKKTLSLIQSLYEIHKVVSYPRTDSKYLSTDIEGTLKERLSALVKFDPRAKQYLGQGAKVKQPAVFNDRKVTDHYALIPTEEPVRAEKLSTDELRMYRLIVERFMGLFADQYVTAVTKATVQFGDHTFTFKQTKVVQQGWHADSKETPTTSVDWQEGAVVPADFSIKEQLTSAPKPLTEGTLLGKMEHYGLGTPATRAEIIEKLVRSELLERRGHSLAVTPKGQQLLKLVNKTLVSPELTGKWENSLEAIARGQENQKAFITEIEAATKTLVSEIKKSETEYHDFAITNKKCPECDHPLKERNTRDGKVYVCTNCHYRRRKDPKVSNHRCPQCHKKMVIIEGQAGAYFRCLNDGTTEKMLDKKDCKKKISKHEERRLIQKVNQEEEPAESPLAAALRKAMEK
(1150) DNA topoisomerase 1 [Lactobacillus sakei subsp. sakei 23K]
1
MAGKNLVIVESPAKAKTIEKYLGRNYKVVASKGHIRDLPKSQMGVDFENNYEPKYISIRGKGETIKELKKHAKKADHIYLAADPDREGEAIAWHVSHILKLDPTDKNRVVFNEITKDTVKSAFKNPRSIDMKLVDAQQARRVLDRIVGYSISPLLWQKVKKGLSAGRVQSVALKLVIDREQEIKAFKPEEYWSLDAEFKKGRSKFKASFYGLNGKKTALGNNDAVQDVLKQIDKTQPFTIEDVKKRERKRFAAAPFTTSSLQQEANRKLNFRTRKTMMQAQQLYEGINLGGKEGTVGLITYMRTDSTRISTGAKHEASQFIHDNYGEEYAAVKAHKTKNPEGAQDAHEAIRPTSVMRTPKSLKDVLTNDQYKIYNLIWSRFVASQMTPAVFDTVAVKINQNNVLFKANGSQMRFPGFTKLYVSSRDTEDSAKDNLLPELAVGDEVKLAKTDPAQHFTQPPARYSEANLVKALEENGVGRPSTYSPTIETIQRRYYVKLNAKRFEPTELGEIVNNLIVEFFPDIVSIDFTADLEHRLDEVETGQENWIKIIDNFYQPFEKEVEKASVQIEKVQIKDEPAGFDCDICGAPMVVKMGRYGKFFACSRFPDCRNTKAIVKEIGVTCPKCGKGQVIERKSKKNRLFYGCDRYPDCDFVTWDKPVGRNCPKCEHYLVEKKIKGGKQVICPNGDYEEAVQK
(486) DNA topoisomerase 1 [Lactobacillus casei ATCC 334]
1
MADKKLVIVESPAKAKTIEKYLGRTYKVVASLGHIRDLPKSQMGVDVDNDYEPKYISIRGKGDVIKSLKKDAKKASKIYLAADPDREGEAIAWHVSHILGLDPKAKNRVVFNEITKDAVKNAFKTPRGIDMDLVDAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKNFTPEEYWSLDAEFQKGRSKKFSASFYGLKNKKQALKNNEAVQKILGQVDKTKPFAVTNVVKKERKRFPSPPFTTSTLQQEANRKLGFRTRKTMMLAQQLYEGINLGGKLGTVGLITYMRTDSTRVSNVAKTETSHYLHEKYGEAYAAVKIRQGKLQEGAQDAHEAIRPTSTLRTPDSLTAVLDKDQMKLYRLIWSRFVASEMTPAIIDTVAVTLDQNGVTFRANGSQTKFEGFTKLYVSSRDSDQKDNILPPLAVGDDVKMLKTDPAQHFTQPPARYSEANLVKALEENGVGRPSTYAPTIETIQKRYYVKLNARRFEPTELGEIVNSLIVEFFPDIVNVKFTANVESELDRIETGEADWVKVIDQFYKPFEKEVAHAETGIAKIQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPNCRNTKAIVKEIGVVCPKCHIGQVVERKSKRNRVFYGCSRYPDCDFVSWDKPVGRDCPVCGHFLVEKKSKAGTQVVCPNNDYKEALQKA
(1100) DNA topoisomerase 1 [Lactobacillus ruminis ATCC 27782]
1
MESPSKAKTIEKYLGNRYKVMASLGHIRDLPKSKMGIDVENNYEPHYISIRGKGDVIKELRKEAKKADHVYLAADPDREGEAIAWHLSYLLGLDPKDKNRVVFNEITKDAVKNAFKTPRAIDMNLVDAQQARRALDRLVGYSISPLLWSKIKKGLSAGRVQSIALNLIIKREKEIRNFKPEEYWTIDAEFKKGRSKFEGSFYGIDGKKTALQNNDAVKSVMERIDTKKPFTVDNVEKKERKRQPPLPFTTSTMQQVANNNLKFRTQKTMMVAQQLYEGINIGRSGTVGLITYMRTDSTRISEVAKHEASEFIHSEYGENYAAIKPRQGKLAEGAQDAHEAIRPSSVLRTPKSLEKYLDKDQMKLYSLIWSRFVASQMTPAVIDTMRVDLEQNGVSYRSTGSKLKFDGFTKVYADSKHKDNMLPDLENGDEVIMSRNQPNQHFTLPPARFTEAALIKTLEENGVGRPSTYAPTLNTIQKRYYVKLAARKFEPTELGEIVDNMIGKCFPDILNVKFTAKLEDQLDEIEEGKQEWVKVVDEFYKPFSTEVKTAEEKMAKVKIKDEPAGFDCEICGAPMVVKMGRFGKFYACSRFPDCRNTKAIVKQIGVKCPQCKRGEIIERKSKKNRLFYGCNRYPECDFISWDKPIARDCPKCGHFLIEKKTKQGMQVKCPNNDYEEAIQK
(242) DNA topoisomerase [Lactobacillus ruminis ATCC 27782]
7
MKQLILAEKPSVARDLSQILGATEKHKDYFEGDGVIVTWALGHLLGLKMPEDLNKDWQKWQLETLPMLPKFIGTKPLPKTRHQLQAIERLAKRSDVKEAVIATDAGREGELVARWILQYVRFNKPVKRLWISSQTTKAVKEGFARLKPASDYDDLYQSALARATADWLVGLNVTRALTVKYQDNLSAGRVQTPTLALVLKQEDKISSFIPQKYYQIALNASNQKALMEQKNPYGIKNREAAQKIVSELERTIGKVEKITVKEHSEKAPLPYDLTELQRAANEKYGYSAKKTLSVVQSLYEVHKIVSYPRTDSKYLSTDMISTMKERLQAVGSMVPEALEYAKKGAKVVQKKVFNNEKVTDHHALVPTEQRPDYAKLSSDEHRIYGMIVKRFVMLFAPEYREQKEKITVSFANRRFNFSKTTVLQKGWKENAQTSGEALHFKEGQQIKGTFEVKEKLTTPPNPLTEGGLLALMERYSLGTPATRAEIIEKLVSSELMERSGNFLRVTRKGRQLLELVNPSLVTPELTEKWEKQLEAIALGKFSSQKFIAEIKDDTKKLVSEVKNSTKKYQDFSMTQKKCPECGAFLKEKKVRDGKLLVCSNAECDYKRRAEARVSNHRCPQCHKKMLIVSGEKGEYFRCKYDGTTEKLGGKKGKKKMSRHEERRLLKKINQDDEPQESALAAALKKAMEEK
(77) DNA topoisomerase 1 [Aerococcus urinae ACS-120-V-Col10a]
1
MATKRKKTPKKDLVIVESPTKAKTIEKYLGRKYKVVASKGHLRDLPKSKMGIDIENNYDPHYITIRGKGDTIKDLKKEAKKANNIYLASDPDREGEAIAWHLAHILKLDPKEDIRVTYNEITKDTVKEAINNPRAIDKDLVDAQQARRILDRLVGYNLSPILWAKVKKGLSAGRVQSVALKMVVDREDEIRNFVPEEYWSIEGVFQKGKETFKANASKYKGKKIDLKNEDDVKALMANLSSDQFEVQNLTKKQRKRNPQKPFTTSSLQQEASKRLRFRTRKTMMVAQQLYEGIKLGSEGTVGLITYMRTDSTRISEGAKQEAGQFIQEKYGKEYIGKGTSGASGQGAQDAHEAIRPTSAFRHPDSVEAYLSKDQFKLYSLIWSRFMASEMAPAVYDTVACDLVQNDVSFRANGSKIKFTGYLRVYPDNNEKDNLLPELENGEKVKSKELTPNQHFTQPPARYTEASLIKTLEELGVGRPSTYSPTLETLIKRYYVKLEARRFEPTELGEIVNSLISEFFPDIVDPQFTANLEDELDHVEDGNKNWIDVVDAFYQPFSKDIEKADQEMEKIEIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPDCRNTKAIVKEIGVNCPTCKEGQVVERKSKKKRIFYGCSRYPDCDFVSWDKPVGRSCPKCDHYLVEKKKRGSKQVICSNCDYKEDVQKGDD
(850) Topoisomerase IA [Leuconostoc citreum KM20]
3
MPNYLILTEKPSAAANFVKALGGKNGQFDTFTYTITNLRGHVMTLKDPEEMVSEDLKKQYKSWLIKHLPWNLNDFNWARTYIRQRNLRTGKVASTKQLVDDLKKEAANGYDAIVIATDTDPSGEGELLAWEALEAIKWRGQVLRANFMDESVKGIQTSMQHLRDVSDKNQDGEYIKGESRNRWDFASMQLTRIATTAAKKQGFKVVAREGRLKSVIVWQIYAQLEAIKRYVKKPYFEVKFKDLAGHIFGRITPEGDVIPWRFDSKAVAQQDLLQYHESAVTNERYQTRTQAPGKLLDLAGLAAILAPRGFSAKEVLSTYQKMYEAQVVSYPRTEDKTVTPEQFNELLPKIDQIAQVVHVDTALLTHRQPRATHVKNQGAHGANRPGENVPTDLATLTKFGASAQAIYEVLAKNYLAMLAEDYVYDHVTANLTDYPIFKTAYNVPVQLNFKAVYDSQRAIKVDDDDETAVMGQLGPTAQPYLYEGANKKPQAPSTKWIMAFLEKHNVGTGATRVSTLSDMSRGTKAMIKETRGKLTLTETGNVSAVMVKGTWIASPKITKRLFEMMDQVGRFEMTMPKLLDSVTQVVVHDMPIMVANAEQLETLLGQPKIKPKRPVSEKTTGQFKGEEITFAKEWSGHVFTDEELTKLLNGAEISFEAKSKRGKLYTATGTMAKQTYKGRTFYGFKLKPKPKK
(141) DNA topoisomerase 1 [Leuconostoc citreum KM20]
1
MAESEKKKTTTTKKTKKTTTKTRKKNLVIVESPSKAKTIEKYLGSTYKVIASLGHVRDLPKSTLGVDVDNNYEPKYINIRGKGDIIKGLRQAAKAAKNVYLASDPDREGEAIAWHLQHILQLDDTAPNRVVFNEITKDTVKNAFKTPRLINQDLVDAQQARRILDRLVGYSISPILWKTVKRGLSAGRVQSVALGLIIKREKEIQSFEPEEYWTLDAVFKKGRSKIQSVFYGVDDKKQQLPDNDSVQDVLRRLNRNEPFEIGKVEAKERKRNPQRPFTTSTLQQTANTQLNFRTRKTMMAAQQLYEGINLGRGIGQTGLITYMRTDSTRISEMARHAATQYIHETWGEEYAQHRLVKQPSAEGIQDAHEAVRPTDVTRTPDSIKDKLTPDQFKLYSLIWSRFVASQMTPEILDTMAVTITQNGVLFRANGSKTKFPGFTKAYPAAKEKDNTLPHLEEGDQVKIEQTDPEQHFTQPPARYSEAALIKALEENGVGRPSTYAPTLETIQKRNYVRLDARKFVPTELGEIVQTIVEESFPDVTNTQFTARIEHELDEVEVGAKYWVPVIDEFFKPFSKEVEKAETTLEKIIMHDELAGIDCSVCGAPMLVKMGRYGKFYACARFPDCRHTETIVKEIGLLCPKCHKGQIVERKTKKQRTFYGCSRYPDCDFVSWEKPTDKTLPDGTTPKENSKNQAKTTD
(197) DNA topoisomerase 1 [Acidaminococcus fermentans DSM 20731]
1
MTNKLVIVESPTKAKTIEKFLGKTFTVRASMGHLRDLPKSQFGVDVEHHFTPKYINIRGKGPLIKELKTLAKKADKIYLATDPDREGEAIAWHLSYILGVDPAAACRISFHEITQTAIKGALKEPQAIDMDKVDAQQTRRILDRIVGYQLSPLLWRKIRKGLSAGRVQSVAVKIICDRQKLIDDFEPEEYWTSSVVLAPGKTPKITADVVKRDGKKLEIHNRAEADQVTEDLKKASYQVTDCAIRDRLRKPAPPFTTSSLQQEANKKMNFSTKKVMMLAQQLYEGVTLGRKGSVGLITYMRTDSVHLADAAVSEIRGYVDANYGPDYLPRKPNVYSSRKNAQEAHEAIRPTSVARTPEAVAPYLDRDQLRLYTLIWKRTVASQMASSISTLTTLTIAGDNYELRATGSVVKFDGFLKLADRKDEEKDKKVPALEKGTALNLIRVNEAVQHFTEPPANFTEATLVKELEEKGIGRPSTYSPIIQTILARGYVAKEGKKLLPTELGKLTIDMLTQYFSPFIDVPFSAHMESELDAISEHRTDKETVLQEFYGPFEKALKVADENIPVVEKPVIVSDVKCEKCGRFMVVKEGRHGKFLACPGFPECRNTKPILVKVGVKCPQCGGELIERHSKTGRLFYGCANYPTCRFTSWDKPTSEKCPQCGSMMVEHKERNGKTVLHCSNEKCPNASLRKK
(766) DNA topoisomerase 1 [Acidaminococcus intestini RyC-MR95]
1
MANLVIVESPTKSKTIGRFLGKNYTVKASMGHLRDLPKSQFGVDVDHDFEPKYINIRGKGDLIKELKTLAKKADKIYLATDPDREGEAIAWHLGYLLGVDPESNCRISFHEITPHAVKEAIKHPAAIDMDKVDAQQTRRILDRIVGYKLSPLLWRKIAKGLSAGRVQSVAVKIICDRQKEIDAFEPQEYWTSSVTLTADKPSHKFTAEVTKKEGKKLVIHNEEEARTVTKELLNQSYAVASSAVKDRIRRPIAPFTTSSLQQEAVKRLNFTTKKTMMLAQQLYEGIALEKRTPVGLITYMRTDSVHLASVAVAEIRNYIGEVYGDAYLPKKPNVYSSRKNAQEAHEAIRPTSVMRTPDEVAPYLERDQLRLYRLIWERTVSCQMAPSVSEVTTLIINGGPYELRASGSVVNFDGFLTLMDKKELAGEKTKKVPHLKEGTPLTLISVDDAIQHFTEPPAYFTEATLVKELEEKGIGRPSTYATIIQTILSRGYVAKEAKKVMPTELGMTTIELLTQYFPNLIDVPFSAHMENELDAISEHKTKKETVLKEFYGPFEKELEIADREIPVKPQEVIVSDVKCEKCGRMMVVKTGRHGKFLACPGFPECRNTKPYYEKIGVACPLCGHDLIVRKTKTGRTFYGCSHYPECHFTSWDKPINETCPLCGHIMLEAVQRGGKVVHHCSNPECPNSGAKKSGLKKVSAKAALAKTEGTAEKTVKKTTAKKTTTAKKTAVMKTASTKKTASTKKTAVKKTGKE
(622) DNA topoisomerase III, bacteria and conjugative plasmid [[Eubacterium] cylindroides T2-87]
7
MNLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDQKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDMTEVVNACDAGREGEMIFRSVYELAGCKKPMKRLWISSMEDSAIREGFANLRPSADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPIPFYTVALELPGLTVSGERVANKAAAEQLKEACQGANVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVASAMPFRKGIAITCDPHTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLMCAVAQPHIYSETVVIAACAGGEFTTKGKTVKHPGWKALEDAYRAKMKDTEPKKEGVEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLSAMETAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIERGQLAPEEFLAGISTMLKDLVGTYQVIKGTEYLFTPLREVVGKCPRCGVEVAELQKGFFCQNDSCKFAIWKNNKWWAAKKKQPTKAVVSALLNDGRVRVTGLYSEKTGKTYDATVVLEDDGQYANFKLEFDQRKGGSR
(1139) DNA topoisomerase 1 [[Eubacterium] cylindroides T2-87]
1
MKKNLVIVESPSKSKTIEKYLGKDYKVVSSKGHICDLATSGKEGLGIDVDHDFEPTYKISKEKKDVVKELKELTKKAKDVYLASDPDREGEAIAWHLARVLDLDIDTTKRIVFHEVTKPAILEAMEHPKHIDMDLVRSQETRRMLDRIIGFKLSKLLQNKIRSKSAGRVQSVALKLIVERENEIKSFKSEEYWSVHANLKKGTQSFEATLSKVDGKKPKLKNEQQASEIVERSKGDFIATSITKRSKKKQPKLPFTTSTMQQEASTKLGFGARKTMSIAQKMYEGIDLGGQMQGLITYMRSDSTRLSDLFVKDTLAYIQDEYGKEYVGKAHTKNKANTQDAHEAIRPTDIKNTPESIKQYLTNDQYRLYSLIYARTLASLMKEASFNVTTITFEVDGLQYSASGQTMAFDGYTKVYKKYEKQTDELLPEIEENEVFHDVVVEPKQHFTEPPARYTEARLIKELEEKSIGRPSTYATIIDTLQKRGYATLEKTSETSKTKVFVPTKQGMLTDEKLGQYFSDVINVEYTADMEKTLDEIAEGKQDSIAYMHQFYDKFAPIVEDAYSKMPKMELEKVGRTCPSCGGDLVYRNGRYGKFISCINFPSCRYTENDEAEQENADPNQEEKICPNCGSKMIIKKGRYGPFWACSNYPECKTIQPLKEKAKPEPTGEMCPECGHELVKRKSRYGTTFIGCSNYPKCRYIKKEPKEKK
(314) DNA topoisomerase 1 [Caldicellulosiruptor kronotskyensis 2002]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAQEAEKVYLATDPDREGEAISWHLATILGLDTNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDVQEFKAKFYGDKKGKIELKNQDQVQKIEEKIKNKEFKVVKIKVSEKKKSPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRVSEEAQQAARSLIVQKFGKEYIPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFRLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGETLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVAKEDRFLKPTELGRIVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVKKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPVKNCPKCGSLMFEKGKKGNKKLVCSNENCAYQEKTGEKGE
(1218) Reverse gyrase [Caldicellulosiruptor kronotskyensis 2002]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEKCLKDDHLTENVFELLKGCGLLKDYQIYWNFHQNYKMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTVSLAQQSFERLNQFKSKIQNTDVIRILLFNSSMKKSEKEEFEQRFLSQDFEILIVTSQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNRENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENSIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFSIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEILQTEKLRQLVSKYISKEDYSKIVNKIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFDSLKSRLMFLLDEEWMEENEVDFESLMEEVKESRKIQNDDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITQDGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKDILKTLRELALEVDEVLIATDPDVEGEKISWDISQYLKPANSNIKRIEMHEITRYGLDSALKSPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKNYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEEECKKVEAEVVEQKIEEIPAPAPFTTSSLLSLASQKLNLGVQQLMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKILVQKVHFRINDIEIVKDIPVKVEEEGWLEFIPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLQELYNDISVLLNK
(480) Reverse gyrase [Caldicellulosiruptor owensensis OL]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEKCLEDDHLTENVFELLKGRGLLKDYQIYWNFHQSYKMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFSALHGKKSALVFPTISLAQQSFEKLNQFKSKIKNADAIRILLFNSSMTKSEKEEFEQRFLSQDFEILIVSSQFISKRKDVLSKMFFNLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLKNKNKENGQNTNLNTLKDKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSREKLLEIINILKDGILLFVNTEEEGKEIVKFLAENGVKIGTTWSNFDEEFELFKEGKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPSFRFSVDMDKAPRFVLERVFVEYLEDHPKLKEYFKNVETLQTEKLRQLVLKYISAESYNKIVQEIFSHLKITDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMDESEANFESLMVEVEESRKSRNEGFNVNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEFHDGKFIPYYNSIKRCTKCYTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNTKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFQSYNLSAGRVQSTILGWIVEREKEYAKSERTFTMLKLENGYNLEIEGEEECKRVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRNFGDEGAHEAIRPVKPISPEELKELVYEKYAQGVSQNHIKVYQLIFNRFLSSQMKNPKVLFQKVCFKIADKEIVKDIPVKIEEEGWLHFLSMQIYPLFENKDYSVTDRRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSLKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILSELFNDLKNLLEN
(244) DNA topoisomerase 1 [Caldicellulosiruptor owensensis OL]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDNQEFKAKFYGDKKGKIELKNQGQVQEIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAIAQMLYEGVEIKGEGSIGLITYMRTDSTRISEEAQQAARNLIMQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTPDQYKLYKLIYDRFLASQMESSIYDVLSAELEVEGYVFRLTGSKLKFAGFMEVYVEGKDTEDEEEESQLPEISEGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTDVVRKYYQPLEKELEIARNTMNKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYHCLEVLCPKCRKRIIERKSKKGKKYYTCEEYPACDLILWEKPVKNCPKCGSLMYEKGRKGNKKLVCSNENCLHEEKIGEKGE
(1255) DNA topoisomerase 1 [Exiguobacterium sp. AT1b]
1
MAKYLVIVESPAKAKTIKRYLGPNYMVKASMGHVIDLPKSQLGVDVEHDFEPKYITIRGKGPVLKELKTAAKKATKIFLAADPDREGEAIAWHLARALGVDETTECRVVFNEITKDAIKESFKHPRKINHDLVDAQQARRILDRLVGYGMSPLLWKKVKKGLSAGRVQSVAVKMIIDREREINAFDPEEYWTIKLDLNHDGETFETSFYGKDGKKMELKSEEDAQSVLDTIDDTFKVIDVTRKERKRNASLPFTTSSLQQDAARKLNFRAKKTMMLAQQLYEGIDLGKKEGTVGLITYMRTDSTRISDLAKTEAKEYIESTFGEEYVALQKQKEKKSANTQDAHEAIRPTSALRDPASLKPYLSRDQLRLYKLIWERLIASQMAPAVLDTVKIDVESNGMIFRANGSTVKFPGFMKVYIESKDDDIEDTNQEKEGLLPPLEVDDTVTFETIEPKQHFTQPPPRYTEARLVRAMEELGIGRPSTYAPTLDTIQRRGYVVLEEKKFLPTELGELVIEMIDEYFNDFITVQFTADMETLLDSIEHKEVEWTEVVAPIYRSFEKRLKRAEEEIEKIEVKDEPAGIDCEVCGSPMVIKMGRYGKFMACSNFPNCTNTKPVQVEIGVPCPNCKDGQIVERRSKKGRLFYGCSNYPECEFVSWDKPVAKPCPVCDSLMVEKKIKDGVKYQCTNCTHTEVHQQEED
(645) DNA topoisomerase [Exiguobacterium sp. AT1b]
7
MRLIIAEKPSQAQKLAAPYPSKKRKEEIEISPCPRFPEGAIVVWAVGHLCELQEPSHYRPEWKSWKYEALPIVPERFDYRISKGKSKPFYAIKKWLHDRSITDVIIASDAEREGEAIVRLILRLAGNKKPLARLWISSLTEQAVDRGFSQLLPGEQTIPYYHEAMSRACADWLVGMNASRAYTTLLKTIGIEDVFSLGRVQTPTLALIVNREREIKQFVPEPYFEVEATLAKGRGTFKAKYTFGKTTKLKTREEADAVVKRASGTAIVKTIDKEEKIEQPPFWFSLSGLQAEAGKRFGFGAKKTLDIAQKLYTKGWISYPRTDSGFVTPDEATLFPQTKARLLKSDAYAGLRDLLTEDPSKNRRYVNAKKVSDHYAIIPTEACGDVTRLGGDEAKLYDLINRRFLAAFAPAAMLEKTTVDLIDGGDLYRAKGTVVVSPGYRQVVEMKSKDVELPALTVGEEFKEKKVEVLSKQTEPPKRYTEGALIMAMKVAGKQLDDEELIHIMKEVEGLGTEATRANIIDGLKKRGYVQLQKKELVPTDKGRLLIDVLGDSILASPVMTAKWEKRLHEIGQASASAAEFIEQAKKMSVHLVEEAKSRVEAANPEGYTIEAKRYGKKGTTRPKASFGICPNCGKGLVEHPKFIGCSGYREGCRFTVSKQVLGVGLVKDELKQMINGGQSNVHTFKKGDKTFNASLYLEKGTLRFEFK
(1584) DNA topoisomerase 1 [Anoxybacillus flavithermus WK1]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGVDIQNDYEPKYITIRGKGSVIKELKTAAKKAKKVFLAADPDREGEAIAWHLAHLLDLNTESPCRVVFNEITKDAIKQSFEQPRAINMHLVHAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIQSFQPEEYWTIQGTFMKGNDTFEAQFYRLGSEPFDLKTEQDVQHVLNHIQGNEFVVTAVTKKERKRNPVAPFITSSLQQEAARKLNFRTKKTMMVAQQLYEGIDLGSEGTVGLITYMRTDSTRVSESAQQEAIQYIEQTFGTSYVATEKRKEKQKANAQDAHEAIRPTSVWRHPSAIKPHVTRDQYQLYKLIWERFIASQMAPAVLDTVAIELSNGSVVFRATGSTVKFPGFMKVYVEGTDDPKDEQQRLLPDFVEGERVFSKDIEGKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVTLENKRFVPTELGEIVLDLMMQFFPEILDVEFTAKMEKSLDDIEEGKVEWVRIIDEFYREFEKRLKIAEVEMEKVEIADESADVDCEVCGSPMVYKMGRFGKFIACSNFPQCRNTKAIVKDIGVKCPRCHEGNIVERKSKKKRMFYGCDRFPTCDFVSWDKPINRPCPKCGGMLVEKKGKKSVHIQCTQCEYNEQQ
(589) DNA topoisomerase [Anoxybacillus flavithermus WK1]
7
MKVIIAEKPDQGKTLASIFQTKKREGYIEILPNEMFPKGAYMTWAVGHLFELASPETYEASWKRWTLDTLPIIPDRFQYEIDRKKAKQFAIIKQLLRKPEVVEIIHAGDAGREGELIIRNIIYMSGVKKPIKRLWISSLTPKAIEQGFRQLLDEKQTRPLYEEAYARTCADWLVGINASRVYTILLKQKGMNDVFSVGRVQTPTLALIVRREKEIEQFHPKPFWEVVATFDVDGKRYEGKWWHENETRTYDRELAEKVSAFCRRKQVEVAEVVCERKTFLPPLLFNLSTLQATANKRFKYSPQKTLDILQKLYQKGYVSYPRSDSQYVTKGEAETFPHILKQLSQKEEYAPYFPLVHESILHNKRYVNEKKVTDHYAIIPTEQVPNLTKLSQDERNIYDLIVRRLIAAHSEEAIFDYTTIVTVVDGRARFISKGKKQIQAGWRDVLMSQDDDVQLLPNVQSGEKGTVYDVYVKEGKTQPPKRYTEGELITLMKTAGKFLDDEQLEKVLAKTEGLGTEATRASIITTLKQRNYIEIKNNQVYVTDKGKVLIDAIGPHLLASPEMTAKWEQRLSEIGEEKASATAFMEQVKKLAAKIVADAVQVANDWSFEGLDTASIQRKKKTTIGKHVGVCKLCGGSVIDKGSFYGCVNYTKTKCSFTISKTILGKSISQANVKKLLAEGKTNVIKGFKKGENTFNAAVIWDETEKRISFSFEK
(82) DNA topoisomerase 1 [Kyrpidia tusciae DSM 2912]
1
MADYLVIVESPAKAKTIGKYLGKGYMVKASMGHIRDLPKSKLGVDIAHDFEPHYITIRGKGDVLKTLRDASKKVKRVYLAADPDREGEAIAWHLANYLDVNPDGPCRVVFHEITKQAVQEAFAHPRPIDRDLVNAQQARRILDRLVGYKISPLLWKKVRKGLSAGRVQSVALRLVCDREKEIREFKPEEYWTLTARFKVDGRTFEAKFVGVGDQKVELANEEEVKAILARISGQSFTVIGVRKSERRRNPAPPFTTSSLQQEAARKLNFRAQKTMSVAQQLYEGLEIGKEGSVGLITYMRTDSTRVSPVAQEQARSYVEKTYGAAFLPEKVKQYQTRSGAQDAHEAVRPTEVARTPESIKAYLNRDQYRLYKLIWERFVASQMAPAVLDTVSADIQAGDVLFRAAGSKVKFPGFMTLYVEGEDDAKDEENRDLPDLRQGQELPEPALEPKQHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLETIQKRGYVLLQERRFVPTELGEVVVELLKEFFPEIIDVEFTAQMEERLDGVGEGRVNWVEMLEEFYQDFQKQLDLAEQAMQHVHLEEEESDEICEKCGRRMVYKHGRFGKFLACPGFPECRNTKPILKSIGVPCPKCGGDLVERRAKRGRIFYGCKNYPSCDFVLWDRPTGEKCPRCGSLLVLRKAKDKETVQCSNPQCDFKGNALEKAEKGNSAGRRSAVETM
(1609) DNA topoisomerase 1 [Halothermothrix orenii H 168]
1
MGNKSNNTLVIVESPAKAKTISKFLGKGYKVEATMGHVIDLPKSKLGINIDKGFEPRYITIRGKGKVLKKLRKEVKKSKDVLLATDPDREGEAISWHLTRALKIDEDKPRIEFNEITKSAIKNALKNRRPIDKNLVNSQQARRLLDRLVGYKLSPLLWKKVRRGLSAGRVQTVAVKLLCNREKEIESFEPEEYWTISASFNKKDKDFIADLYRISGKKFKINNEKEAKQILEDLNKSKFVVSDIKEKTRKRNPNPPFTTSTLQQRASSILGFSAKKTMYLAQQLYEGIDMGSEGTTGLISYIRTDSTRISREAQKQALDYIKEAFGDKYIPDKVKVYKAKEGSQDAHEAIRPTSVDRTPGKVKKYLNKDQYRLYKLIWERFVASQMSPAQYKQVKVLIKAGDKYIFRAKGSRIIFPGFLRVNTSSQKKDIILPPVKKSERLDVKEIKPEQHFTQPPPRYTEATLVKTLEEEGIGRPSTYAPIISTIISRGYVERQGKQLKPTELGFIVTDLLSKYFPDVTDIEFTAHMEERLDKIEDGKDEWRNVLEDFYSNFSRRLKEASEEMEEVKLEDEVTDEVCEKCGRNMVIKYGRYGKFLACSGYPECKNTKPYVIKTGVKCPQCKEGELVQRKSRKGRTFYGCSSYPDCKFVVWNKPVKEKCPECGGLMVEKNSKKQGRYYLCINKECGYKKEV
(115) DNA topoisomerase [Symbiobacterium thermophilum IAM 14863]
7
MAGKPLIIAEKPSAAMAIAQALGGFQRRDGYLESAEYLLSWAIGHLVELLPPEAYDPRWKRWTMETLPILPEGFGLHVLPKTRSQFRTLARLGKQAPLLVNACDAGREGELIFRYICAAAGLEKPVMRLWVSALTPAAIRAAFAEMKPQEHYDRLYRSARCRAEGDWLVGINATRAFTVKFGELLSAGRVQTPTLAMVVRREREIESFRPEPYWEVFAAFRTPDGREYTGKWFGPDGDRLSSADAAEAVVRRVRRQAGWVEASDERPVAERPPQLFDLTSLQREANRRYGLTAAATLKAAQALYEAKHITYPRTDSRYLSRALVPQLPALVRALSARSDLAALAAGADLSRVGFGNRRVVDDAKVTDHHAILPTSEVPRSLTGAEAKIYDLIVRRFLAQFYPDARFLEQEVVTCVGELPDRFRSRGRRLVDPGWRQVEPEPARKRRAAEDEEEEGLQLLPPLRMGEPVAVGDVESREKATRPPRRYTEATLLSAMEYAGREITDEALREAMKGHGLGTPATRAAIIERLKEMGYIITERRSLVPTAKGRRLVELAERAGVEVLLSPELTGEWEHRIAGIQSGEYDDARFMQEIRELTARLVERIRATEGAPGRGGAGRSSTAEPGPAKEEPAAGGPPLQDRLPTPCPRCGGPVTRGSRGWTCATAGCGLRIPTFLCGKVIDGGAAEALLSRGRTPLITGFTSPRTGRRFSAFLVLKEDAQVGFEFPPDRRGSRRTRKAPGEGDAPSRGPGEAETSSPNRSDGASAGVSPRRGRPGSRAGARKP
(1530) DNA topoisomerase 1 [Symbiobacterium thermophilum IAM 14863]
1
MPKSLIIVESPAKAKTIEKFLGRKYAVKASMGHVRDLPKSQLGVSVENDFEPKYITIRGKGDILKELRESARKADRVYLATDPDREGEAISWHLAQVLKLPLDEPLRIEFHEITKDAIQRAIKQPRPIDLNRVEAQQARRVLDRLVGYKLSPLLWRKVRRGLSAGRVQSVAVRLIVDREREIQAFQPEEYWTLDARLSTAFAQSFSARYWGMGEQKADLKTQDQVRAVVHQVAGDRLPAGNAAVSGEGTPGDPFTEVLDLAGEGLVLQVRSVKRREKKRNPAYPFTTSSLQQEASRKLGFSVRRTMAVAQQLYEGLPLGEEGHTGLVTYIRTDSTRIADEAARAAAEFIERQYGKDYVPERRREPDRRAGEQGAHEAIRPTDVTRTPESVKPYLTPDQYRLYRLIWERFLASQMAPAVLDTVTVELVAGEHVFRASGQSIRFPGFMKVYIEGEDDDGQREEGDDLLPELAEGQQVTLQTLEARQHFTQPPPRYSEAMLVKALEERGIGRPSTYAPIIGTIQTRGYVEKRDKRFYPTELGVLVTDILKEYFPDIIDVEFTAHLEGKLDEVEEGRVNWRELIRRFYGPFEETLKQAEEKVGGFELEDEVSDVPCEKCGRLMVVKHGRFGKFLACPGFPECKSTKPILEETGVTCPACGTGRIVERKSKKGGRRFYGCTNYPDCNFVSWEKPVNRLCPECGAPYLVEKRIKELGLSHVCKQPDCGYVEPVESMEEVHA
(179) DNA topoisomerase III [Bacillus selenitireducens MLS10]
7
MQLIIAEKPDQGAKLAAPFNPQKKKNFITIPACSHFPEGAVVTWAVGHLCELVPPEHYRSEWKTWSMDTLPILPEEFRFQVIKGKGKAFQTIKSFIHDQDITGIIHAGDAEREGEAIIRMILHQARNQKPVKRLWISSLTPDAVKEGFSALLDSIDTDHLYDEALSRSFADWLVGINASRAYTLQFKKHGINDVYSTGRVQTPTLALIVKRENEIDEFVSKPFWEVHATFSHEQGSYGAVWHKDGDSRLLNSVMAERIQAFCTNRPARILDQRVKQKAIPAPSFFNLSSLQAAMNKRYTFSPKHTLEIAQKLYVKGYISYPRTDSTFITTQEERQFPGILKKLEKKEPFSAHFPLPFSSLQNRNRYVNEKKVRDHYAIIPTEQVPSFSKLSADEQKIYEVIVNSLIAAHYPPLMMSYTEIDTIVDERAEFKSKGKSVISPGWRDVIPFPKANSQEQWLPNVDKGDAVTGDSFEVKESETKPPKRYTEGELITLMKTAGKHVDDRELTGILHETEGLGTEATRANIIAVLQQRNYITITKNTVFPTDKGKLLITALGSSPLASHAITARWEQALSSIGNGKKSKDEFMASIHTFIQNLIDESLHLSAEWVFTPEDIAKLPARKSKWDAYKNRSKEPLGPCPICGAQVMDKGKFYGCEAYLSNKCSFTLSKRIMKKTLPKTAVKNMLKSKESPVISGFQSKGKSFAASMIWSESEKRFIFDFKEPRKMKPE
(998) DNA topoisomerase 1 [Bacillus selenitireducens MLS10]
1
MSDYLVIVESPAKAKTIGKYLGKKYNVKASMGHVIDLPKSQMGVDVENNYEPKYITIRGKGPILKDLKQAAKKAKRIYLAADPDREGEAIAWHLADSLKIEEGSKCRVVFNEITKDAIKESFKHPREINTNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVAVKMIIDRENEINAFVPEEYWSITAHLSKDGKQFEAKFQQLDGEKKPLSSKEDVDDILNRLEGGSFEVTGIKRRERKRNPVAPFITSSLQQEAARKLNFRAKKTMMLAQQLYEGVDLGKSGTVGLITYMRTDSTRLSDTAKGEAKEYIGIHYGEEYHQEPKAAKKNEKAQDAHEAVRPTSVMRDPKAMKPHLSRDQYRLYKLIWERMVASQMAPAVMDTMSVDLDVNGAMFRATGSKLKFAGFMKVYIEGNDEGKEEKDKLLPDLNQGDKPASEKVEPAQHFTQPPPRYTEARLVRTMEELGIGRPSTYAPTLDTIQRRGYVSLEEKRFVPTELGTIVLEMIEEFFPEILNVEFTADMETRLDSVEEGSEEWIRIIDEFYQGFEKRLKYAEEEMKEVEIKDEPAGEDCEKCGHEMVYKMGRYGKFMACSNFPNCRNTKAIVKEIGVGCPKCEKGQIVERKSKKRRIFYGCDQYPECDFISWDKPIARTCPKCSEMLVEKKSKKTVQVVCVSCDYKEDSV
(513) DNA topoisomerase 1 [Geobacillus kaustophilus HTA426]
1
MSDYLVIVESPTKAKTIERYLGKKYTVKASMGHVRDLPKSQMGVDIDHGYEPKYITIRGKGQVIKELKTAAKKAKKVFLAADPDREGEAIAWHLAHMLDLDIHSDCRVVFHEITKDAIQQSFQQPRAINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREREIREFQPEEYWTIQATFQKEGETFAASFYSIDGQKRDLKTEADVKAVLDRLNGTAFAVKTVTKRERKRSPVPPFTTSSLQQEAARKLNFRTKKTMMIAQQLYEGIDLGSEGTVGLITYMRTDSTRVAETAQQEAAAYIEATFGAMYVNQEKRKEKKSTNAQDAHEAIRPTSAFRDPDKVKPYLTRDQFRLYKLIWERFIASQMAAAVLDTMSVELENNGVVFRASGSKVKFPGFMKVYIEGTDDQTEEQDRILPDLEEEETVESETIESKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVVELMLEFFPEIIDVEFTAKMEKELDEIEEGKVEWIKVVDEFYREFEKRLKVAEKEMRAVEIKDEPAGIDCEVCGSPMVYKMGRFGKFIACSNFPECRHTKPIVKEIGVKCPKCREGNIVERSTKRKRVFYGCDRFPDCDFVSWDKPLARPCPKCAGLLVEKVLKKGVQVQCTACDYEERLEA
(803) DNA topoisomerase [Geobacillus kaustophilus HTA426]
7
MKVIIAEKPDQGATLASIFRTKKRQGYIEILPNDLFPDGAYMTWAIGHLFQLAPPERYRPEWKRWTLGTLPIIPERFEYEIEKAKAKQFKVVKELLRKPEVTEIIHAGDAGREGELIVRNLIRLSGVNKPMKRLWLSSLTPKAIEEGFRRLLDERTTRPLYEEAYARACADWLVGMNASRVYSLLLKERGMNDVFSVGRVQTPTLALIVRREREIEQFRPEPFWEVVASFVIGDKRYEGKWTDKNGQTRLGDEEMAKKIAAFCQGKRAEVADVHTERKTYQPPLLFNLSTLQATANKLYRFSPKKTLDVLQSLYQKGIVSYPRSDSMHVTKGEAETFPAILQKLSSFPAYASYFPLPQPSILQNKRYVNEKKVTDHYAIIPTEQVVDPEKLSADERKVYDLVVRRLIAAHHQAAVIDYTTVTTLVDGRARFVSKGRQVVEEGWRAVIRPHEEEKDAALPLLERGEAGEAAAVKVKEGKTEPPKRYTEGELITLMKTAGKFLDDEELEKVLAKTEGLGTEATRAAIITMLKERKYIEVKNNLVYATDKAKVLIEALGGTILASPEMTAKWEQRLSEIGEGSASPAAFMEQVKKLAQKVVADAIAAAPNWNFRGVDTASIQRTRKKKTMGEKLGPCPLCGGTVVDKGTLYGCDQYAKTKCPFTISKRILGKSISAANVKKLLSQGKTNVIKGFKKGEKTFDAILVWDENEKKLSFQFPKR
(1640) DNA topoisomerase [Geobacillus kaustophilus HTA426]
7
MKSLVLAEKPSVARDIARVLGCKQAHKHYFEGKQHIVTWALGHLVELKMPEDYDRKYETWRLEDLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIATDAGREGELVARWILEMIGWTKPIWRLWISSQTDRAIRDGFRQLKPGVQFERLYQSAVCRAEADWLIGLNVSRALTTKYNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKIGSITAVWERHGGHRLFDQDEANRLMTRLKGQPARVTSIKRKRKSEPAPLPYDLTELQRDANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMEATMTERLLAMKSGYEDVIAPLLAKGKAKAAKRVFNDDKVTDHHAIVPTDERLNLSRLSTDERKLYDLIARRFLALFYPPHESETTTAVFDIGGETFVAKETAVVNAGFQAVLSKEDNKAQPTLLHLAEGQTLPSVQLELEQSFTEPPARYSEADLLAQMEKYGLGTPATRADIIERLVETEVVERKDGRFYPTKKGKQLIELVNEELKSPELTARWERELEAIARGKGNPQQFLANIRRQTQQLVAEIKQSEQVYKAPNLTNLTCPECGALLKERKTKDGRMLVCSNLQCRYRRRRDPKLSNRRCPQCHRRMEMHEGKAGLYFQCRPCNIVEKADETKRIAAKGSERALLKKYSASNESFGVSLGELFKQALSQKEE
(578) DNA topoisomerase 1 [Lactobacillus brevis ATCC 367]
1
MPTKAKPKAKTKTRRKPQKKLVIVESPAKAKTIEKYLGRTYKVVPSLGHVRDLPKSSMGVDTENDYDPHYISIRGKGDVIKGLRSEAKKAKAVYLASDPDREGESIAWHLAHVLNLDVTDKNRVTFNEITKDAVKEAFKTPRSIDMNLVNAQQARRILDRLVGYSISPLLWKKVKKGLSAGRVQSIALSLIIQREKEIKAFIPEEYWTIDGEFKKARHTFAASFYGLNGKKTGLKDNDAVQAVLSKLDKKGNFDITNVVRKERKRTPQPPFTTSSMQQDANRKLNFRTRKTMMAAQQLYEGINLGKEGTQGLITYMRTDSTRISNIAKHEASTFIHEKYGAEYAATKPIKGKLPEGAQDAHEAIRPTSVFRTPASLKERLTKDQFRLYQLIWNRFVASQMTNAIMDTMAVTLEQNGVTFRANGSKMKFEGFLKIYKDGKEKDNLLPDLEIGDQVKLAKTDPAQHFTQPPARYSEANLIKALEENGVGRPSTYAPTLDTIQRRYYVKLVGRRFEPTELGEIVDGIINDYFPDVVNVDFTADLEHELDGIEDGKQDWVKVIDSFYKPFSTEVAHAEDAIEKIQIRDEPAGFDCDIYGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKEIGVTCPVCHKGEVIERKSKKNRIFYGCSRYPDCDFVSWDKPVGRDCPKDGHYLVAKKIRGGSQIVCPNGDYEEAPQK
(466) DNA topoisomerase 1 [Lactobacillus fermentum IFO 3956]
1
MSLATKQESTTKKKTTRRKVSRTNQKKLVIVESPSKAKTIGKYLGRTYKVVASLGHVRDLPKSRMGVDIDHDYQPDYISIRGKGDVIKELRKDAKAAKAVYLASDPDREGEAIAWHVANLLKMDPTEKNRVTFHEITKDAVKEAFKEPRTINMNLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSVALNLIIQRENEIRNFVPEEYWTIDADFKKGREKFQASFYGQNGKKANLKNQEAVQAVLQQLDRQQDFSITKVDRRERRRMPQPPFTTSTMQQDANRRLNFRTRKTMMAAQQLYEGINIGQGAAVGLITYMRTDSTRIAGVAKHEASTFIHEHYGAEYAATKPVKGKLQEGAQDAHEAIRPTSVNRTPAEMKEFLTPDQYKLYNLIWSRFVASQMTPQVTDTMAVTITQNGVDFRANGSKVKFDGFTKVYKGSQGKDNILPNLEEGDAVKMVADNPAQHFTQPPARFTEAALVKTLEENGVGRPSTYAPTLDTIQRRYYVKLESRHFEPTELGEIVNDLITKQFPDIVNVKFTAEVEDSLDKIEEGKENWVQVVDGFYKPFSKEVATAEEQVAKIEMKDELAGSNCEICGAPMVIKMGKYGKFYACSRFPNCRNTKAIVKDTGVECPLCHQGTVVERKSKKNRVFYGCSRYPDCDFLSWDRPIGRDCPKDGHFLVEKKVKGGKQVLCPNGDYKEEVQK
(1546) DNA topoisomerase 1 [Selenomonas sputigena ATCC 35185]
1
MPTAQKKTPQEKNREVVGQAEKKEGKRAAGKGAAKTAAVEKPAAKKSAVKKASAKKTATKKSAARDSTATTSAAEKKPAAKKSAPKKTVAKKTVAKKTVAKKTAAKKTAAKKEAPQTLVVVESPAKAKTIEKYLGKKYMVRASMGHLRDLPKSQFGIDVENDFAPKYINIRGKGDLIKALKKDAKHAAKVYLASDPDREGEAIAWHLAHILGIDPNENCRIVFNEITKPAIQAAVKEPYPINLDRVDAQQARRMLDRIVGYKLSPLLWRKIKKGLSAGRVQSVTVKLICDREKEIQAFVPEEYWTVGMKLKKGRGAQFAAELATVDGKKLALHSKEETSALVKDMAKQSFSVKEVKKRERRRNPVAPFTTSSMQQDASRKLGFTSRRTMMIAQQLYEGVELGRRGPVGLITYMRTDSTRLSDLALDEVRGYVGTSFGADYLPEKPNIYAAGKKAQDAHEAIRPTSVENTPELMEKYLSREQLRLYTLIWQRFVASQMTPAVFDTVSVSVAAGERYIARASGSTLKFPGFLAVYADNKKEKDVLLPELAAGEALSLLDLLPEQHFTEPPPRYNEASLVKTLEEEDIGRPSTYAPIIETILARGYVVRQDKHFQPTDLGFLVNDMLEEHFKDIVDVQFTAGLENELDEIAEGKVDKNDLLRGFYEPFEKTLEEADEAIGEVEIPEEVSDVICEKCGRNMVVKQGRYGKFLACPGFPDCRNTKPLLKDTGVPCPKCGGRIVERRSRRGQAFYGCENYPACDYVTWDQPLTEKCPECGAFMLRHRYKNGRILPYCSNEECKTRIDHPINKEIEKSRARLEAKKAKEAAAAEKAAEAEATT
(1108) DNA topoisomerase [Selenomonas sputigena ATCC 35185]
7
MRLYIAEKPSMGREIAKCLEGPVRAHDGWLETAEGAVTWGFGHILRQKEPEEYSEKYKFWRTEDLPIVPAEWQLVVAPSAARQFRIVKDLIARADEIVHAGDPDREGQLLIDEVLDFVGNEKPVKRILLNALDEKSIREANADLRENSDFYALKQSALARARADWLIGMNLSRAYTLAARRAGHKKLVLPVGRVKTPTLALVVRREREIEGFKPVDYFEIRVKFRHADGDFTAVWKPREEEPGLDREGRLVDEAAAQARLAGFAEPPADGHVTELHRAKKTEGQRLPFSLSSLQVLAGRKYGYEPQLVLDTAQKLYEKKLTTYPRSDSEYLPLNQRKDASAILAHLRDGDDAALSHWAGGADAKIKSRAWNDKKVTAHHAIIPTRVRARLGTLTETEENIYRLIAQAFIAQFYPEHVYEKTHAVLDYHGEVFAVNGRREIQAGWRAIYRTAKKGAGEEADAGDADGEEEDGGVLPPLKKGDAVTYLSGALKKRATKPPPRFTPATLLQGMKEIHKYVLDPEAKKRLKDVYGIGTEATRAAIIDDLIKRRFLSAKGKKKLLYPTDTAYLLVDALPDDLVYPDATALWEDKLHSMADGEGTLEEFLSAQVAFTRRLVAKALDAKIERGGEHPCPRCQNGVLVKRRGKNGDFWGCSNYPRCRMSCDDKEGKPDLGSRAPRAASARSAPSRAGQKDVRPARNFGAPALSEEEMAAFLAEYAPLPSAQEMMNSPSDGKKGAGKAKAVVE
(1547) DNA topoisomerase 1 [Selenomonas sputigena ATCC 35185]
1
MPTAQKKTPQEKNREVVGQAEKKEGKRAAGKGAAKTAAVEKPAAKKSAVKKASAKKTATKKSAARDSTATTSAAEKKPAAKKSAPKKTVAKKTVAKKTVAKKTAAKKTAAKKEAPQTLVVVESPAKAKTIEKYLGKKYMVRASMGHLRDLPKSQFGIDVENDFAPKYINIRGKGDLIKALKKDAKHAAKVYLASDPDREGEAIAWHLAHILGIDPNENCRIVFNEITKPAIQAAVKEPYPINLDRVDAQQARRMLDRIVGYKLSPLLWRKIKKGLSAGRVQSVTVKLICDREKEIQAFVPEEYWTVGMKLKKGRGAQFAAELATVDGKKLALHSKEETSALVKDMAKQSFSVKEVKKRERRRNPVAPFTTSSMQQDASRKLGFTSRRTMMIAQQLYEGVELGRRGPVGLITYMRTDSTRLSDLALDEVRGYVGTSFGADYLPEKPNIYAAGKKAQDAHEAIRPTSVENTPELMEKYLSREQLRLYTLIWQRFVASQMTPAVFDTVSVSVAAGERYIARASGSTLKFPGFLAVYADNKKEKDVLLPELAAGEALSLLDLLPEQHFTEPPPRYNEASLVKTLEEEDIGRPSTYAPIIETILARGYVVRQDKHFQPTDLGFLVNDMLEEHFKDIVDVQFTAGLENELDEIAEGKVDKNDLLRGFYEPFEKTLEEADEAIGEVEIPEEVSDVICEKCGRNMVVKQGRYGKFLACPGFPDCRNTKPLLKDTGVPCPKCGGRIVERRSRRGQAFYGCENYPACDYVTWDQPLTEKCPECGAFMLRHRYKNGRILPYCSNEECKTRIDHPINKEIEKSRARLEAKKAKEAAAAEKAAEAEATT
(1212) DNA topoisomerase 1 [Thermoanaerobacterium thermosaccharolyticum DSM 571]
1
MEKSLVIVESPSKAKTIHKYLGKNYKVEASMGHIRDLPKSQLGIDIEKNFEPKYITIRGKGPIIEKLKKEAKNASKIYLATDPDREGEAISWHLANLLNIDVNDKCRIEFHEITKNAIQNAIKNPRKINMNLVDAQQARRILDRLVGYNISPLLWKKIKRGLSAGRVQSVATRLICDREKEIEEFKPEEYWSLSAFLYKEKKTQYFEAKFYGTKDGKIDLKNENDVNNIIKDLADDYIVDNVKTGTKKRNPSPPFITSTMQQEASKKLGFTAKKTMMIAQQLYEGVEIKGEGSLGLITYMRTDSTRISEEAKKAAYEYILQKYGKEYANPNTTYTKKGGNIQDAHEAIRPTYINLDPDQIKDSLKPDQYKLYKLIWSRFLASQMSQALYDTITMDIINKNYIFKASGSKLKFAGFMTVYIEEADTENIEEKTLPLLEKGDHLKLKVLKPEQHFTQPPARYTEATLIKELEEKGIGRPSTYAPIISTLLERGYVIKEKKNLKPTELGFIVTDVMKEFFPDIVDVKFTAEMEEQLDKIEEGIEKWCDVIDGFYNNFNDSLKVAEEQMKDIEIKDEVTDIKCEFCGRNMVIKYGRYGKFLACPGFPECKNTKPLYEETGIICPKCGGKIIVKKSKRGKTYYACENSSQCGTMFWDKPINETCPKCGNLLMEKYIKGNKVIKCSNCDYVK
(1750) DNA topoisomerase [Bacillus anthracis]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLDTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTEIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDESDTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYDGKWEKDNESRLQDPDMANKIAAFCQGKPAVVKEMKTERKEFQPPLLFNLSSLQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFDEYKGLLPAPVESIMNNKRYVNEKKVTDHYAIIPTEQVTNPSRLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTIVTLVDERAEFISKGKQQIQEGWRKVIFQDDKDDETILPIVAEGEEGKVVKVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVKKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGTASPATFMEQTKKLSAKIIEDAVEMSEKWDFTGLHVESIERKGSKFTTGKKVGSCKKCDGDVIDKSTFYGCSNYNTTQCDFTISKKILSKTISQKNMTKLLKGEKTDLIKGFKKGEKTFDAKLEWKDNKINFVFEN
(351) DNA topoisomerase 3 [Bacillus anthracis]
2
MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
(837) DNA topoisomerase 1 [Bacillus anthracis]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(1751) DNA topoisomerase [Bacillus anthracis]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLDTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTEIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDESDTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYDGKWEKDNESRLQDPDMANKIAAFCQGKPAVVKEMKTERKEFQPPLLFNLSSLQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFDEYKGLLPAPVESIMNNKRYVNEKKVTDHYAIIPTEQVTNPSRLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTIVTLVDERAEFISKGKQQIQEGWRKVIFQDDKDDETILPIVAEGEEGKVVKVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVKKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGTASPATFMEQTKKLSAKIIEDAVEMSEKWDFTGLHVESIERKGSKFTTGKKVGSCKKCDGDVIDKSTFYGCSNYNTTQCDFTISKKILSKTISQKNMTKLLKGEKTDLIKGFKKGEKTFDAKLEWKDNKINFVFEN
(352) DNA topoisomerase 3 [Bacillus anthracis]
2
MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
(838) DNA topoisomerase 1 [Bacillus anthracis]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(836) DNA topoisomerase 1 [Bacillus anthracis]
1
MSDYLVIVESPSKAKTIEKYLGKKYKVVASMGHVRDLPKSQMGIEVKNNFTPKYITIRGKGPVLKDLKSAAKKAKKVYLAADPDREGEAIAWHLANTLNVDVESDCRVVFNEITKDAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSVAVRLIIEREREIQSFEPEEFWTIKTEFVKGKDTFEASFYGVDGEKVQLTNETQVNEIIEQLKDNAFSVENVTRKERKRNPALPFTTSSLQQEAARKLNMRAKKTMMLAQQLYEGIDLGKQGTVGLITYMRTDSTRISETAQTEARTYITEAYGTEYIGAEKKKETKKSNAQDAHEAIRPTSVMRKPEELKSFLSRDQLRLYKLIWERFVASQMASAIMDTVTARLINNNVQFRASGSVVKFPGFMKVYVESKDDGAEEKDKMLPPLEVGETVFSKDLEPKQHFTQPPPRYTEARLVRTLEELGIGRPSTYVPTLETIQKRGYVGLDNKRFVPTELGEIVIELILEFFPEIINIEFTANMEQSLDEVEEGNANWVKIVDDFYVGFEPRLEKAEKEMREVEIKDEPAGEDCELCNHPMVFKMGKYGKFMACSNFPDCRNTKPIVKEIGVTCPKCDKGQIIERRSNKKKRLFYGCGTYPECDFVSWDKPIGRKCPKCEGMLVEKKLKKGVQVQCISCDYEEEQQM
(350) DNA topoisomerase 3 [Bacillus anthracis]
2
MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVRINKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGEGAGQIFACKCGYREKLSTFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFAEALKKLKFD
(1749) DNA topoisomerase [Bacillus anthracis]
7
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHAEWKKWSLDTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTEIIHAGDAGREGELIVRNIINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDESDTINTYYEAYTRSCADWVVGMNASRVFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYDGKWEKDNESRLQDPDMANKIAAFCQGKPAVVKEMKTERKEFQPPLLFNLSSLQATANKAFKFSPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFDEYKGLLPAPVESIMNNKRYVNEKKVTDHYAIIPTEQVTNPSRLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTIVTLVDERAEFISKGKQQIQEGWRKVIFQDDKDDETILPIVAEGEEGKVVKVKVKEGKTQPPKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVKKNQVYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGTASPATFMEQTKKLSAKIIEDAVEMSEKWDFTGLHVESIERKGSKFTTGKKVGSCKKCDGDVIDKSTFYGCSNYNTTQCDFTISKKILSKTISQKNMTKLLKGEKTDLIKGFKKGEKTFDAKLEWKDNKINFVFEN
(102) DNA topoisomerase 1 [Bacillus megaterium WSH-002]
1
MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLAADPDREGEAIAWHLAHSLDVDIASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKVELSNENDVTNIVKQLDGNEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISETAQTEARDYITNAYGNQFVATEKRKEKKNSNAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEFYSDFEKRLEHAEKEMREVEIKDEPAGEDCEECGSPMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCPKCEEGNIVERKSKKKRTFYGCDRFPGCDFVSWDKPIARKCPKCENLLVEKKQKKGTQVVCTSCDYKEEAQQ
(1314) DNA topoisomerase [Bacillus megaterium WSH-002]
7
MKLIIAEKPDQGSTLASQFKPKRHDGYLEIPPNEVFTDGAYVTWAVGHLCQLVSPEDYKPEWKKWSIDTLPMIPDRFQYEVTRSKAKQFQVVKKLLKKPTVTEIIHAGDAGREGELIVRNIIQLSGVHKPMKRLWISSLTPKAIYDGFQQLKDESDTRNLYYEAYTRACADWVVGMNASRVYSILLKKHGMSDVFSAGRVQTPTLALIVKREKEIDNFKSEPFWEVLAKFDIEGKKYEGKWHQDGESRLKEKEMAYKIAQFCEGKDAEVHELVTERKEFQPPLLFNLSSFQATANKAFKFSPKKTLDVLQGLYQKGIVSYPRSDSNYVTEGEAETFPEILEKLSAFSEYEHLFPLPYSSILGNKRYVNAKKVSDHYAIIPTEQVKDPSKLSGDEQKIYDLVVRRLIAAHYEKAIFDYTTITTLVEKRAAFISKGKQQIQEGWRKVIFQNEKDDDVILPNVQEGEEGKVIKVDVKEGKTQPPKRYTEGQLITLMKTAGKHLDNDELEKILAKSEGLGTEATRAGIITMLKDRKYIDVKKNQVFATDKGKVLIDAIGDKILASPEMTAKWEQRLAEIGEGAASAAAFMEQTKKLSAKIIEDAVEAESKWNFSGYDTESIQRKGKGKGKSFSSKSFGSCKLCDGKVVDKGSFYGCSNYAKTKCTFTVSKKILGKTVTQANLKKLLSEGQTDLIEGFKKGDKTFNAKLEWKENKVQFLFEK
(216) DNA topoisomerase [Bacillus megaterium WSH-002]
2
MKSLVLAEKPSVARDLARVLGSTQTKKGYIEGPKYVVTWALGHLVELQTPEDYDNQYKTWRLEDLPIMPEKMKLKVIRKVSSQFRTVSDLAKRKDIGELIIATDAGREGELVARWIMEKVRWNKPFKRLWISSQTDKAIRDGFKQLKPGKEFNRLYDSAVCRSEADWLIGLNVTRALTTKYEEPLSAGRVQTPTLAMIIEREQVINTFKPSEYWTLTAQFSSFEAAWQKGNEKRIFDEKRAKELHSKLSGEAVVNTIKRKMHKEAQPLPYDLNELQRDANKRFNFSAKKTLNVLQKLYEQHKLVTYPRTDSRYLTTDMVSTMKERLESISAVYKEEVRPILRNAQLPKRVVNNEKVSDHHAIIVTDQPVFLQDLSADERKLYDLIAKRFISLFYPAYEYEVVKAELEVNGEQLVASGKQVVNAGFKKVSGGESEATVKLPDMKEGSKLSIQDVTMKSAFTEPPQRYTEADLLGQMEKHNLGTPATRADIIEKLLQNESIDRQNNRLHATKKGKQLIDLVADELKSPELTAKWERELEAIAKGKGNAKEFLTNIREQTEKLVKQVKTSNQTYKPHNLTGSKCPECGTFLKEKKTKQGRVLVCSSLECSYRRAKDPKLSNRRCPQCHKRMEIHSGKAGTYFQCRSCQVVEKAEDKKKKISKREERKLLNKYNDDGAFGSSLGDALKQALQDKKD
(886) DNA topoisomerase 1 [Streptococcus agalactiae A909]
1
MATTTKTSTKKTSKKKSATAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINDLKKEAKKAKKVYLASDPDREGEAISWHLAHILDLDKEDRNRVVFNEITKDAVKNAFVEPRQINMDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFQPEEYWTIDGSFKKGTRKFNATFYGLDGKKFKLSNNEDVKTVLKRIKTDEFLVEKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMIAQQLYEGLSLGTAGHQGLITYMRTDSTRISPLAQNEATEFITNRFGANYSKHGNKVKNASGAQDAHEAIRPSSVNHTPESIAKYLDKDQLKLYTLIWNRFIASQMTAAVFDTMKVNLTQNGVTFIANGSQVKFDGYMAVYNDTDKNKMLPDMEEGESVKKVNTNPEQHFTQPPARFSEASLIKTLEENGVGRPSTYAPTLETIQKRYYVKLAAKRFEPTELGEIVNSLIVEFFPDIVDVTFTAEMEGKLDEVEIGKEQWQKIIDEFYKPFEKELAKAETEMEKIQIKDEPAGFDCELCGSPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVICPICQKGQVIERKTKRNRIFYGCDRYPECEFTSWDKPIGRTCPKSNDFLVEKKVRGGGKQVVCSNEKCDYQEEKIK
(134) DNA topoisomerase 1 [Streptococcus uberis 0140J]
1
MVTKTKSVAKTAKKKATKKKSTSPQKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPEYINIRGKGPLINSLKKEAKNAKKVFLASDPDREGEAISWHLSHILGLESDDKNRVVFNEITKDAVKNAFLEPRVIDMDLVDAQQARRVLDRIVGYSISPILWQKVKKGLSAGRVQSVALKLIIDRENEIKAFVPEEYWTIDGLFKKGRQKFQASFYGLNGKKMKLETNDDVKFVLSHLKSDAFDVTTVEKKERRRNAPMPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGINLGSNGTQGLITYMRTDSTRISPIAQNEAAAFITERFGSNYSKHGNKVKNTNGAQDAHEAIRPSNVHYTPESIAKYLNKDQLKLYTLIWNRFVASQMTAAIFDTVKVTLEQNSVSFIANGSQIKFNGYMAVYNDSDKNKMLPEMTQGEVVTKESTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLEVIQRRYYVKLSAKRFEPTELGEIVNKLIVEFFPDIVNVTFTAEMEAKLDQVETGERQWQTVIDTFYKPFAKDLEKAEDEIEKIQIKDEPAGFDCDLCGHPMVIKLGRFGKFYACSNFPDCRNTKAITKEIGVTCPICKKGQVIERKTKKNRVFYGCDRYPECEFTSWDIPVGRECPKSGDYLVEKKIRGGGKQVVCSSESCDYKEEKIK
(1728) DNA topoisomerase [Oenococcus oeni PSU-1]
7
MTTVILAEKPSQARSYVEALKNSTKKEGYFSVSDPVLANETFITYGFGHLVELATPEKYDQKYKRWSLSNLPIFPDKYKFIVPRDKKTQFKIVKDLLMKADTIIIATDSDREGENIAWSIMNQAKINLKSKTIKRLWINSLEKDAILNGFKNLKDAWNYYPAYQEAQTRQISDWLVGMNGSPLYTLLLRQSGVRGVYSIGRVQTPTLYMVYQRDQEIKNFKPEPYFEISAEIEANRQKFVAKLDPYQRFKDEESLTIYMEAKGLRTGFQEALTKDVLQETKRTASPRLFSLSSLQSAINKRYHASASDVLKAVQALYEAKLLTYPRTDCNYITDQEFSYLLSNLMGYLSLVSSQVSLNNTEANKRYVNSKKVQEHHAIIMTKTIPNKAKLAALPKLQQQVYGLVLRTTLAMFADPYEYEQTIIITEVGKANFKATGNVPIKQGWKLLFADDKDKNDETVVTLPKVTKNQKVQADLKTPQKETTPPVPFTEGTLITAMKTAGRTLDDEEAQSILKDVEGIGTEATRANVLEVLKKRGYLLSKKNQLHVSEQGITLCTAVELEPLLTSPEMTAKWELALKEISQKKRSQESFLIQIKKFVSKLVDEVPTQMKQSEGLSKQVKNQKIVEIQDRQQEAIGRCPLCKEGMIVDKGKFYGCTNYKAAVPCRFTLPKKWSEKTIGKTAIKALITKGESNRLKGFKSKKSGKKFDAKLKLEGSKLSFDFS
(3) DNA topoisomerase 1 [Oenococcus oeni PSU-1]
1
MVTKKKKAKKLVIVESPAKARTIENYLGRDYEVLASMGHIRDLPKSQLGVDTEHNYEPKYINIRGKAPLINSLKKAAKSASAVYVASDPDREGEAIAWHLGHILGLPDGGKNRVTFNEITKPAVKEAFKHPRGIEQDLVDAQQARRVLDRLVGYSISPILWQKVKRGLSAGRVQSVALGLILDKEKEIAAFVPKEYWSLNANFKAGKHEFSAEFYGTDGKKVKLDNQKSVSKILKRIDSSKDFKITDISTKESKRNAPNPFTTSSLQQTANSQLNYHARKTMQIAQGLYEGISLPKIGHVGLITYMRTDSTRLSETAQEMAKKFIVDKFGKEYYHRHNVVKKSENVQDAHEAIRPTDAERTPESLKEILTRDQYRLYNLIWSRFIASQMSEQKLENQSLMIEQNKTVWRATGIKVLFEGWTMALKTSSTKNNILPALKIGDLVQMVNNLPEQHFTQPPARYTEASLIKALEELGVGRPSTYAPTMDTIQRRGYIGFDQKKIVPTDLGDIVQDVVVKSFPEVTDKQFTSKIEDELDKVETGNVKWQKVIDEFYKPFSKEVDAAIENLEKVPIYDRIAPELCDICGSLMVIRRSRRGEFYACSRFPDCHGTKSIVEEIGMKCPKCGIGEVVIKRTKRGRIFYGCSRYPDCDFASWTKPKKNEETEENNETK
(209) DNA topoisomerase 1 [Clostridium thermocellum ATCC 27405]
1
MADKLIIVESPAKAHTIGKFLGKDYKIVASVGHVRDLPKSQMGVDIENDFTPKYITIRGKGEIISKLKKEAKNASTIYLATDPDREGEAISWHLATLLNIDKNEKCRITFNEITKNAVKNAIKSPREINMDLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTITAKLLKGGVKAPFEAKFYGLDNKKTELKSEEEVNKVLDEIKDAVFVVQKVKKGEKKKNPNAPFTTSTMQQEASRKLGFSTKKTMMVAQQLYEGIEVKGVGAVGLVTYIRTDSTRISEEAQNQAAKYIKEKFGESYLPKEKNVYKNKSASQDAHECIRPTSVEMDPESVKDSLTKEQYRLYKLIWDRFVASQMAPAVYDTINADIEAGKYLFKASGSTVKFPGFTVLYQEDKDDETEEGEVIVPELAEGESLKLKKLEPRQHFTQPPPRYTEASLVKALEEKGIGRPSTYAPIITTILARGYVVKEGKTLVPTELGKIVTDIMKNYFQDIVDVEFTAQMEKTLDEVEEGEKRWVDVMRSFYSQFVDVLKNAEEKIGNIEVPEEVTDEICEKCGRNMVIKVGKKGRFLACPGFPECRNAKPILEDAGVTCPKCGGKVYIKKTRKGRKYLGCENNNSDPKCDFMTWDMPSKENCPKCGSFLLKKYSGRKVQLKCSNENCDYVKTGKEKKEDE
(1294) DNA topoisomerase 3 [Clostridium beijerinckii NCIMB 8052]
2
MSKTLVLAEKPSVGRDLAKVLKCNQNKGSYIEGSKYIVTWAMGHLVGLMDPEGYDNKYKEWKMETLPMLPKHMKLTVLKKTGRQYNEVKKQLLRNDVSDIVIATDAGREGELVARWILEKSGVKKPLKRLWISSQTEKAILDGFRNLKPGAAYENLYKAAVCRAEADWLVGLNVTRALTCKYNAQLSAGRVQSPTLSMIVLREDEIRNFKPKTYYTLEGKTRGFNLAWVNKDNNSRIFDEEFANKVASKLKNSEGKIVNINEANKKKFSPALYDLTELQRDANKIWGYSAKQTLNIMQRLYENYKILTYPRTDSRYITTDIVATIPDRLKAISIGEYRIVAEELLKGKIIGNKSFVDNSKVSDHHAIIPTEQKPNLALLSSEERKIYDLVVKRFLSVMLPPFEYIQTTIEAEVQGEKLVAKGKVIKAKGWKKLYDRLEEDSDEEEIKEQVLPTVSIGNSIRVESVNIKKGETKPPARFTEATLLSAMESPHKYINVSKEAAKTLGETGGLGTVATRADIIEKLFNSFVIEKKGKEIIPTSKGKQLMELVPKDLKSPLLTAKWESQLDEISKGKRDDHSFIKEMKNYSVALVEDVKGTNNKFVHDNKTGKKCPNCGKYLLEVKGKNGVMNVCQDRECGYRESVARVTNARCPECKKKLELRGNGEGAIYVCPGSNCNFREKASQFKKRFEKNGKIDKREVNNYMKKMKKEAEEFDDNPFAALLGDIKFDK
(975) DNA topoisomerase 1 [Clostridium beijerinckii NCIMB 8052]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIENNYTPKYITIRGKGELIDKLRKAAKKAEKVYLATDPDREGEAISWHLANILKISEDETCRIVFNEVTKTAVKASIKQARKIDLDLVDAQQARRILDRLVGYEISPILWKNVKWGLSAGRVQSAALKLICDREKEINEFIPKEYWSIDCTLKKEKKKFPVRLSTYKGKKIEIGNEETSNGIIKELNKGNFVVKSIKKGKKNRNPLPPFTTSTLQQDANRKLNFMTKRTMSIAQVLYEGVEVKNYGTVGLITYMRTDSVRISEEAQESAKEFIEGSYGKEYLPGAPRVYKGKKNIQDAHEAIRPTYVEITPEIAKENLTPEQYKLYSLIWNRFVASQMASCELNTHSIDIENGDYKFKASGSVISFDGFMKIYEYSNEEDENSVMLPELKENEELKVESLNGTQHFTQPQPRYTEASFVKLLEEKGIGRPSTYVPTISTLLGRNYVIREKKNLIPTELGEIVNNIVSEYFRQIVDVDFTADMERKLDDVEEGSENWTQIVEEFFSPLKVAIEKAEKEISKVVIEDKVSDVKCEKCGRMMVIKRGRFGEFLACPGYPECKNAKPIVEELDVPCPECGKPIVAKKSKKGKKFFGCLGYPECKFVSWYEPVKEKCPNCNSYMVAKYSKTKGNYIQCSNSECNYKEEVKKDNSKEE
(1168) DNA topoisomerase [Clostridium beijerinckii NCIMB 8052]
3
MAKVIIAEKPSVAKNIADAFNVKTRRDGYFEGNGYYITWAFGHLLQLYDAKDYDENMKGWRFEKFPFIPEHFLYKVKCDSVDRTVEDKGAKKQLGIIKSLIDKEDVDGIVSATDFDREGQVIADELFGYFKVKKPIYRLLLNEWTPDEVKSGMESLKDNKEMQPLQDAGIGRQWSDWIIGINLTSVSTLKYKFEENKTINIGRVLLPTLKIIYDRDKEIENFTATTYYKLVSNFKTSANEEFEGLYYENDSEKFEKKEDLDKFISRLEGATAKIIDKQTELKKEYPPYLFNLSNLQGHITSKYKGWTSDKVLKVAQSLYEKKLTTYPRTASVVLEESLKDRAKKVLNTLKAGLPYEKDIKFSTSKRIFDSSKVESHSAITPTYIKPSGLSSDEKIVYDAIKNRFIMQFMPIAEFEETKVTLKANVSEMNGIFVSKGKVKLVEGWKVVEKIESKDVILPKIEIDETVDIVDSKVNSVTKKPPKYHTEKTLLRVMETCGKGIEGKDEDSEEMMQAILSGFSIGTPATRAETIKKLKDIGYLKTKGKNLMCTELGRNLVETFPVKELFDLEYTGRLEKTLSDIEKGKFAKSEFIKLITDFTIQSVELIKKDDAALSRFKVEIPKDSENIGPCPVCGNPVIEGEKSFGCSNWKNGCKYTIWKDDRYIASFGKKISKEMVELLLKNGKVGFRNLKSKKGNTFSAYFKYEKNEESGYFNWKIEFIDNK
(1834) DNA topoisomerase 1 [Carboxydothermus hydrogenoformans Z-2901]
1
MKKLVIVESPAKAKTIGKFLGKEYVVKASMGHIRDLPTYRFGVNIEKDFAPTYEIIRGKKELIKELKEEAAKAEKVYIASDPDREGEAIAWHVKEVLDLEDNGDLRIEFNEITKDAVLQAIANPRGIDYNRVYAQQARRILDRIVGYKLSPLLWRKIKKGLSAGRVQSVAVRLICEREEEIEKFVPEEYWSLTAHLEAEKKPFKAKLSKYQNRKIEIKNKDEVERIIAEVSQRDFKVVKITKKLTKKSAPEPFITSTLQQEASKRLNFSAKKTMQIAQALYEGLEIGEYGVTGLVTYIRTDSTRVAEEAKAKAAAYIKNTFGEEYVGTEKKTKAPKGKIQDAHEAIRPTDIEKDPEKIKQYLTPDQYKLYKLIWERFVASQMSDAQYDVTTVDIEAGDYLFRATGSILRFPGFTKIYQVEEEEGEKEEKEKLPALMEGQSLTLLKLEPKQHFTEPPPRYTEATLIKALEEKGIGRPSTYAPILETILKRGYVEKDKKQLKPTELGRIVVDLLKEHFPDIIDVEFTAEMEEKLDQIEEGEKNWIEVLRNFYEPFNETLRQSYEKIEKIILPLEETEEKCPNCGRNLVVRTSRFGKFLACPGYPECKFIKPFVQKTGATCPRCGGEIIVKKSKKGRVFYGCSNYPSCDFVSWDLPSSKKCPNCQSVMVEKRPKKKPPYLLCTNPDCKHTEPLEEVQ
(1634) Reverse gyrase [Thermoanaerobacter tengcongensis MB4]
6
MALATGAKYYHSCINCGGINTDTRNEKGLPCEVCLPFEDGDVLKGLKLNNSLKGYEKYWNLNQQYKEFEEFFFSKINKKPTGYQRFWAKRLLLSKSFTLVAPTGVGKTTFGLISALWIAKKGGKVALVFPTVSLVEQAAKRLIEFSKEDEDVNILFYTSSLKKKEREKFEKNFSEGNYDILVISSQFISKRKEQLSQKVFDLVFVDDVDAVLKSSKNIDTLLNMIGISQKAIDSTLDNLKKGNNSDKIQIEEKAPKGRLIVSSATAKPKGIKPLLFRELLGFEIGRFTTSARNITNVRIKEKSLEKLLYIINLLKDGILLFVPTEEEGKEIANYLEEHGVKLGKTWEDFEKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFSTKLENAPRFILERNFQDYLENNPKLKAYFKDLQRLSTEKLRKSVEKYISPETWEKLIQKNFPTTKFDKEKNLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFEEDDSLFELLKARLLYLTEEEWTEEGEIEHLVKEAEETRKAISTDSSSKDMKSRMIIVESPTKAQTISKFLEKSSTRRYGSLMVHESITQEGILLLTASKGHLYDLETKTGLHGVEINDGRFIPYYNSIKRCSSCGAQFTDELPRCPYCNSDKIDDKKKILEALRDIAMEVDEVIIATDPDVEGEKIGWDISQYIKPVNKNVQRIEMHEITKFGFDKAIRNRRNCDVNLVKSQIVRRIEDRWVGFELSLRLQKNFQNSNLSAGRVQSTVLGWILEKEIEHSKSKKTVTQFTLDNGFKFEVDGKIDVDEVEVEIVEEKEQALSPLPPFNTPSLLTAASQQFKLPVQQIMEILQTLFELGFITYHRTDSTRISSTGQKIARSYLEKIGKITLLSEREWGKEGAHEAIRPVKPISPEELSEFITEKIAAYLSPMHIKVYSLIFNRFMASQMTSPVVINQKILIKNGSFQVEREVPVKLQEEGWNIFNPITVYTPFEEKKYSVVSKRTYTTHTVPLFTQASLIEEMQKRNIGRPSTYAKIVDILFKRKYIIEDVYKRLRTTALGRKVYSYLSERYMNYINEETTRQLEKLMESVETGEKDYQSVLKNLYEELNEILIKN
(1490) DNA topoisomerase 1 [Thermoanaerobacter tengcongensis MB4]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASQGHVRDLPKSQLGVDIENNFAPKYITIRGKGEIIEKLKKEAKDAEKIFLATDPDREGEAISWHIAQLLDLDIDKPCRIEFHEITKNAVQAAIKNPRKIDLNLVNAQQARRILDRLVGYKISPILWKKIKRGLSAGRVQSVAARLVCDREREIEAFVPEEYWNITAVLFDEKTSSKFEAKFYGREEEKIELKNREEVDKIINSLSEEYVVYKVKTGTKKRNPPPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGIEIKGEGSVGLVTYIRTDSTRVAKEAKEEAYRYITEKFGKEYANPDAEYSSKKANVQDAHEAIRPTSVFREPEIIKDSLTPDQYKLYKLIWDRFIASQMMPAIYDTVAMDIKNNGYIFKASGSSVKFLGFMTVYVEGSDFQEEEEEKTLPVLKEGTKVRLEELKPTQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTIATLLERGYVVKDKKVLKPTELGFIVTDALKEFFSEIVDVGFTAEMEEQLDKIEEGKVEWYEVVGDFYRDFYKTLKVAEEQMEKVELEEEVEVTDIKCEVCGRPMVVRKGRYGKFLACSGFPECKNTKPLLEKVGVKCPKCGGEIVKRRSKKGRVYYSCENAPQCDFVLWDKPVNEKCPVCGSLMVEKNTKNGIVIKCSNPECGYQKETN
(864) DNA topoisomerase 1 [Caldicellulosiruptor hydrothermalis 108]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQEIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGKEYLPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTPDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVRKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRVIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPKCGSLMFEKGRKGNRKLVCSNENCAYEEKIGEKGE
(1658) Reverse gyrase [Caldicellulosiruptor hydrothermalis 108]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEECLAQEQLNENIFESLKKKGSLKHYQLYWNFQQIYSMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFSALHGKKSALVFPTISLAQQSFERLNQFKSKIQNADAIRILLFNSSMTKSEKEEFEQRFLSQDFEILIVSSQFISKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKNKSNEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFEFFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEYLQTEKLRQLVSKYISYEDYSKIVNKIFSHLKLTDDGKLIIPDVPTYIQGSGRTSRMFGMNLTKGVSILFEEDDTIFESLKSRLMFLLDEEWIDESEVNLESLIMEVEESRKSRNEDFNVNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWIGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSERTFTLLKLENGYSLEIEGEEECERVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISATGQNIARMFLEKVGKKELFLPRSVGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKIEEEGWLEFLPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILQELYNDISVLLNK
(1688) DNA topoisomerase 1 [Thermoanaerobacter pseudethanolicus ATCC 33223]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKGYANPEANYVSKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVEEFYKDFYKTLKIAEEQMEEIEVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPDCDFILWDKPVEEKCPVCGSMLIEKNTKNVHILKCSNPGCDYQKEVK
(1077) DNA topoisomerase 1 [Clostridium sticklandii DSM 519]
1
MGKNLVIVESPAKAKTIGKFLGKNYTVKASVGHIRDLPKSKLGVDVENDFEPQYITIRGKGSVVNELKKQAKKSDKVYLATDPDREGEAISWHLAYLLGLNEEEPIRIEFNEITKDAIKKAIKHPRKIDRPLVDAQQARRVVDRLVGYKISPILWAKIRKGLSAGRVQSVTTKLICDRENEINAFEPEEYWSIDAITQIDKKNKVDFKFYGDEKGKIELHSKDEVDLILKSIKNKDLVVKAVEKKERKRSAPKPFTTSSLQQEASGKLSFTTKKTMIVAQQLYEGVDIKGKGSLGLITYIRTDSFRISDEAQENAKNYINDKYGKDYFKKYQNNSKSKKKIQDAHECIRPSYVDLAPEDIEDSLSKEQFKLYKLIWERFIATMMADAIYDSQNISASIDKYIFKTNGSKLKFDGFMKVYSFSSQEETILPDMKEASVFPVKKIDPKQHFTQPPARYSEASLVKTLEELGIGRPSTYAPTISTILQRDYVEKKSNSLIPTELGFIVTEIMSENFKEIVDYTFTADMENNLDKIEDGEIEWQNIVKDFYSPLEESIEKAVENIEKVILEEKTDEICDICGSEMVIKFGRFGKFIACKNYPECKGTKPILERIGIKCPECSDGDVIIRKTKKGRIFYGCSSFPKCRFVSWDRPNGEKCPKCDSFLVLSKTKTTEKIKCSNKECDYEK
(245) DNA topoisomerase [Clostridium sticklandii DSM 519]
3
MSYPEKYDIKYKAWRLHDLPFLPEEYKYEIIANVQKQFDIIKEQMNRDDVTTIYVCTDSGREGEYIYRLVDMMVDAKSKEKKRVWIDSQTEDEIKKGVKNAKPLEAYDNLADSAFLRAKEDYLMGINFSRLLTLCYGRTLAKKLEKDHIVIAVGRVMTCVLGMIVNREREIRDFVKLPYYKIQALFEFEGSIDYDAEWKAVEGSKYHLSNQIYKEVGFTDKALAETFVNELKTSKEKPVIEDVKKKKETKNPPLLYNLAELQNELSKKLKQSPDQTLKIAQNLYEKKLITYPRTDARVLSTAVCKEILSNLKGLTQLDKVASLDEKDKTLPEYALEVINSNKHKGLEKTKYVNDKAITDHYAIIPTGQGLSTYNKLPGIEKEVYILIVRRFLAIFFPPAIYNQLSITTKLEDERFFSTSKVCTSEGFQVILNDEKKEDDSKQDKAEILKKLKKGQTVLVKELDIKESETTPPKRYNSGSIILAMENAGKLIEDDELREQIKGSGIGTSATRAEILSKLEKIDYISLNKKTQILTPTTLGESIYDVVAGSIPSLLRPELTASWEKGLSMIASGDIKNDEYMKKLESYIQKNTSRVLTLTKNTNVKNKASEIDKTPLGSCPLCKDGKIKENSKAYFCTNWKQSCNFTLWKNSLPELKEDISRDLVKELLASDKNSIKVHTSENKDIHIKFKESGNGELEITKSH
(1659) DNA topoisomerase 1 [Desulfotomaculum reducens MI-1]
1
MSKTLVIVESPAKAKSIGKYLGKNYTVKASMGHVRDLPKSQFGVDVENAFSPKYITIRGKGDILKELRSAVKKVDHVLLASDPDREGEAIAWHLTKLLEIDEETPCRIEFNEITKNAIQAAVKQPRRIDVDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEIQAFIPEEYWTLTGKFLKSAKSPFEAKLHKHKNKKIVIPNQETMDKILAELKGAAYVVSNVTRKERLRNPAPPFTTSSLQQEASRKLNFTSRKTMVVAQQLYEGIDLGKEGPVGLVTYIRTDSTRVSETAIEETRSFIMERFGPAYVPKQPRQVVAKGKVQDAHEAIRPTSVNRDPDSIKQYLTNDQFKLYKLIWSRFLASQMASAVIDTTSMDISAGDYLFRATGSIIKFPGFMQVYIEGNDDGHKEEESVLPELAKGDKVQAKDLTPKQHFTQPPPRYTDATLVKVLEEKGIGRPSTYAPIVETIQRRGYVVRENKQFYPTELGVIVVDLLKNHFPEIINVEFTADMEKKLDQIAEGEQQWAGVLRDFYEPFSQTLETAEEAIGKVQVADEVSEEICEQCGRNMVIKLGRYGKFLACPGFPDCRNTKPLLEPTGVGCPKCEGEMVLRRSKKGRKFYGCSRYPECEFVTWDMPTKEKCTQCGEMMVEKKSRGKEKVLQCVNEHCPSKGEKAASNINGNKKKTVKNNKK
(349) DNA topoisomerase [Desulfotomaculum reducens MI-1]
7
MKTLVITEKPSVGKDIASVLGRFESKDGYLENEKYIVSWAFGHLVELADPSVYDPVFKKWDLATLPIIPDSFKLVEIAGSSAKQLRTLKKLLNSAEVSQVVNGCDAGREGESIFRRIYHFCGCRKPIKRLWLSETTPAAVKAAFKALREGQEYNNLAAAAEARGQADWLVGLNGTRAFTVRHGTVLSVGRVQTPTLNLIVSREREINNFVPVPYWEVWGTFQTDNGMYKGKWFREKEDRLPNREAALNLTTKLSSEAKGQVISLEQKEAKELPSFLFNLNDLQKEGNRRYGFTAQQVLDIAQSLYEKHKLLTYPRTDSRHLSNAMISTLPERLATLKNAPKYAELIPDTLPGLSKRYVDDGKITDHHAIIPTAVDPSKAQLSDQEKKIYDLVVRRFLSIFYPEARYAVTEVFTETAGELFKSRGRVELAAGWKMVWRGSDQETAEEGNGDDPEDQALPPLTQGKSVDVSKVEILEKQTKPPKRFTEATILAAMESAGKFVEDKEMAEVLKQTGGIGTPATRAAIIERLIKVGYVARDKKSLVPTAKGQILIDLVPKQLKSVELTASWEDGLRRVEEGQQNAALWIQDIQAYTRELVVLARNQEVSQGVGTARDTLGKCPVCGRDVVETAKSYGCSGYKEGCKFAIWKEINSKKISAKQAETLLTKGKTGLIKGFKSKAGKTFDALLVLGEDGKITFGFANAVNDQPGSTGNTALGKCPLCGKDVVENSRSYGCSGYKDGCKFVIWREIAKKKITQTQAIELLAKGKTGIIKGFKGQKGSFDAALTIINGEIKFAFAERM
(1707) DNA topoisomerase 3 [Desulfotomaculum reducens MI-1]
2
MHKSLVLAEKPSVARDIARVLNCYKKGNGYLEGDKYIVTWALGHLVTLADPEVYDEKYKSWRLEDLPMLPSPLKLVVIRQSSKQFQIVREQMNRKDLREIIIATDAGREGELVARWIIEKARVVKPLKRLWISSVTDKAIQDGFKKLRDGKEYQNLYAAAVARAEADWFVGINASRALTCKFNAQLSCGRVQTPTLAIIAKREEEIRNFRPKTFYGITVVTDQLKLTWQDRQSKDIKTFHKEHCDQVLSLLNQKTAEVIEVEKTAKKSYSPQLYDLTELQRDANKFFGYSARETLSIMQRLYEHYKVLTYPRTDSRYLSSDMVDTLAERLKACSDQPYTKLAYKILKNPIKPSKSFVDDNKVSDHHAIIPTEQPVTVSTFSDKERKIYDLVVRRFLAVLYPPFAYEQTTIKAKMGEELFIARGKVVIAQGWKEVYQHDLEEEEPKDSLSEQTLPVIKRGDCLKVRSLTQTKGETKPPEPFTEGTLLSAMENPAKYMSQDNKELIKTLDKTGGLGTVATRADIIEKLFNSFLIEKKGKHIAITSKGKQLLELVPEGLRSPALTARWEKELEFIAKGILNKSQFINEIKKYATTVVHEIKESENRFRHDNLTGTKCPECGKRMLEVNGKKGKMLVCQDRECGYRKGLSKVTNARCPECHKRLELHGEGEGQIFVCKCGYREKLTTFHERRKNEKGSNISKKDVNKYLRNQETKDDFLNNPLAEALAKLKLKS
(1794) DNA topoisomerase [Desulfotomaculum reducens MI-1]
7
MKQLILAEKPSVGRDIVNAIGGHFEKRDGYYENSQYIISWAIGHLVELCEPEDYQPNLKKWTLSALPIIPECFKLKPNPKTIKQYKVVKQLLNRPDVELIAGTDAGREGELILRYIMRLSGYSRPFKRLWLSETTPESIRKGLANPLPGQAKDLLAAAAECRSHADWLIGINATRAFTKKHGDLFSIGRVQTPTLGLIVAREKEIKTFIPAHYWELYADFVTTDGQVYRGKWFKNKNKNRFNQEADGISIKNKIVGQDGSVIKVEEKAVSEPPPTLFNLNDLQKEANKKFGFTASQTLEIAQALYEKHKLLSYPRTEFKHLTNELAKTIPSRLSALGSVSGYSKFVAYAQSAPKPGKRFIDDAKVGDHHALIPTNVKPTAALSPNEAKIYNMVARRFLAMFFPAAEYKQTKIMTSVSDETFLTSGKIELSPGWKEVIPPLKGENKEKSDEEVLLPPLTKGENVAVTKAKLQQKKTEPPKRYTEGTLLAVMEGAGKFVDDKALKDAMKGHGLGTSATRAAIIERLIKVGYVERKSKTLIPTQKGETLISLVPEVVSSPQMTGEWEKALADIEAGQVNPKRFMSEIISLTKKIVNLAKEQKTNGYMPESTKEVVGKCPLCGREVVEYAKKFGCGGFREGCAFSFGKQILKKKITVKQAKQLLTNGKVLIKGFTSSKTGKKFDAALVLKDGKVSFDFS
(593) DNA topoisomerase type IA central domain protein [Ruminococcus albus 7 = DSM 20455]
3
MKKLIICEKPSLAKNVRDAIAHRENVQRVGNKDLYYYESSSYVITFCFGHLLTLGEPEKYIAEGETAVLPIIPANFRLFPNDKDCARQYSLIKKLMDMPEIDGIIHCGDADREGEIIVRNVLRVARNTKPVYRLWLPEQTESTILKALSSLENDSKYDDLANAGYARTFVDWLFGYNLSRYLMQKANVRKGWGVGRVIIPIVDTVYQRELEIRNFVSTPYFQLHGETEKDGIKVTITDKEKFDTQEQAQLRLTELSSGVYRVGSIDTKKAVVTPPKMFSLDTLQGKLSKDLGMTLDKSMPIIQSLYDKKFITYPRADTEYFAEEEKADVFAVADKMNAVYSLDLEHKVSKKIFDSSKVESHSAIRPTLNFPTNESGLSDDEQKVYNTIVKRFCAVFAPPCTVNRTVIVFTDGTHEFKIKGDTPLTPGFRRYEPPKKTNDNDEDNKMLPSFSPGELVSFSWVIDNKMTKAPPRYTIDSLNAYLKAPFAKSSSAQDNDDSPADDSELYEAVKKGMEIGTVATRTGLITKCVKTYKYLDIKQGKYYCTEKGEAFIGYLHQLNIDLFTERNIEFNMMIKSVELGKETMQHSIDKTADELRRIIAQDVTVCSAQKFTDSNSLGKCPFCGSDVLDGTKNFYCSAYKSGCKFVIFKNTYCHFSFVKDGKEINYTKPMSLTKSNCKALLSSGSTTVSIEEKNGKGKYKIGVTFKPDNKHEFVGIERIREKKKEG
(436) DNA topoisomerase 1 [Ruminococcus albus 7 = DSM 20455]
1
MSDLVIVESPHKAKTVKRYLSGDYEVVASMGHLRDLPKSKLGVDIENDFEPQYINIKDKESLIKEIKKKAKASDHVYLAGDPDREGEAISWHLAQLLGLDMNDKNRVTFNEITKSGIDAGMSNPRTIDLNLVNAQQARRILDRIVGYKLSPFLWRKIRRGLSAGRVQSVAVKMICDRENEIRAFVSQEYWSIDAMFLAEGSKKAFASKVDTVDGAKPDLKSKADADAVLKRLEGAEFIVDKVKKSVRKKNPAAPFTTSTLQQEASRRLGFQGRRTMKAAQELYEGLDIKDMGPTGLITYMRTDSLRISDEARAAAYDFIKEKYGDAYIPEKPRVYKTKGSAQDAHEAIRPTNPAITPELVKASGVTNDQYKLYKLIWERFIASQMANCTMDTMSVDIAANGVMFKATGYSVKFDGFTVLYEESKDEEEEKKNVLPPLAKGDKLTPKEILGNQHFTQPPPRYTEATLVKAFEETGIGRPSTYVTTVTTIINRNYVERDGKQLKPTSLGEVTNELMSEHFDKIVDVKFTANMEKSLDDIESGKIGWVKTLQKFYKEFDSELGTAEKEMEGKRVKVPDEATDEICEVCGKPMVIKIGRFGKFMACSGFPDCKNTKRIVQETGGDCPFCGKRVLLKKSKKGKKYYGCENNPECSFMTWDIPTEEKCPRCGSTLFQKGGKNGILICHKQDCGYQRSLSGESAGSEE
(861) DNA topoisomerase 1 [Clostridium cellulovorans 743B]
1
MGTNLVIVESPAKAKTIRKYLGKNYVVEASMGHVRDLPKSQTGVDVENNYEPKYITIRGKGELLDKLRKQAKKSEKIYLATDPDREGEAISWHLSKVLKLSETEKCRIEFNEITKTAIKAAIKSPREINMNLVDAQQARRVLDRLVGYGISPILWRKVKWGLSAGRVQSATLRMICERDKKIKEFIPKEYWTIEGIFNSTDDTKNSKEKLNLKLHNFKNEKIEIDTKEKADEILNIIKSGNYTVSKVKKTERIKNPLPPFITSTLQQDAYRKLNFTTKRTMSIAQQLYEGIEIKGKGSVALITYMRTDSVRISDEAQKSALEFINTSYGTEYVPSEPRIYKGKKNIQDAHEAIRPTYIDITPDKIKGDVKDEIYKLYKLIWERFVASQMKSCVLDTVSVTVDNSGYNFKANGSTVKFDGFMKIYSYGTEGDESLTTIPKVQEGEMLSCIQIDGLQHFTEPPARFSEASLVKTLEENGIGRPSTYAPTIATLLSRKYIEREKKTLVPTELGIIVDNIMCEFFNQIVDEEFTANMEERLDDIELGDSDWRKIVNEFFTPVKAEIEKAEIELAKITIEDEVTDIQCEKCGRNMVIKHGKFGDFLACPGYPECENTKPIVEEIDTPCPKCGSKIVVKKSKKGRKFFGCSTYPNCDYVSWYEPSSKKCNQCGSIMLKKYNKTNGNYLECSNSDCKSKEIIQEETE
(274) DNA topoisomerase type IA central domain protein [Clostridium cellulovorans 743B]
3
MSKVIIAEKPSVAKNIAEALKSNIRKDGYLEGNGYYITWAFGHLLQLYDAKDYDEKMAKWKMDNFPFIPKAFKYKVKNDSKKKDKPDAGAKKQLKIIEELINRNDVDMVISACDYDREGQIIGDIITGYLKVKKPVYRLLQNEWTADEVIKGMEKIKPNTEMKSLRDAGISRQWADWTIGINLTSVATLKYQRGKGNPLNIGRVLLPTLKIIYDRDKEIANFVPDNYFKLNATFKTSDNIEYEGAYIEKEQEKEQEKFKEREKLDEISKKMKGCTGVIVDKQTEKKKEYPPYLFNLSNLQGYITSKYKGWTSDKVLKVAQGLYEKKYITYPRTASVVLEESLADRAAKVLNTLKKSLPFQEEVKFIKNKRIFDNSKVESHSAIIPTYLEPKTLSGDEEKVYSAIKNRFIAQFMPIAESEETKIFTRIKNFDLDGIFISKGKVQIVEGWKKVEKIESKDTILPFVNINDEVDTIKTKVSAHSTKPPKRHTEKTLLRVMETCGKKFDEEQSDQMMDAILSGFSIGTPATRAETIKKLKDIGYIYTEGKNLICSELGVKLVETFPIQELFDLEYTGRLEKTLADMEKGKVEKEDFLKLIFDFTTNAINQIKGDKENVINQYEGELVKGESLGKCPCCGNDVIEGKIGFGCSNWRSGCKYVVWKEDKFLMSMGKKITKDMVMSLLADGKVAIKGLKSRKGNIFDASLSYEKNKDNDYFSWKMEFLNSQESKNRT
(756) DNA topoisomerase 3 [Clostridium cellulovorans 743B]
2
MSKTVVLAEKPSVGREIARVLKCTKSGNGYIEGPKYIVTWALGHLVTLADPEVYDDKYKSWRLEDLPMLPKPLKLVTIKQSGKQFNAVKEQLNRKDVDEIVIATDAGREGELVARWIIEKARVKKPMKRLWISSQTDKAILDGFRNLKPSAQYENLYRAAQCRAEADWVVGLNVTRALTCKYNAQLTAGRVQSATLAMIVSREEEIRTFVPKDYFVINAKAKGFNLQYRDKNNNSNIFEVDKVNKVLSAVRGKEANIVEVTESYKKQYSPALYDLTELQRDANRIYGYSAKQTLSIMQRLYENYKVLTYPRTDSRYLSTDIVATLPDRLRAIAVGSYSAVANEILKGKITGHKGFVDNSKVSDHHAIIPTEEKGKLALLSSEERHIYDLVVKRFLAVMLPPYEYLQTTIKADINGETFVAKGNVIKAKGWKKVYDKEATLAEDEDDKDSQTLPVVKKGDKLNVMSIDSEKHKTKPPARFNEGTLLSAMEKPQKYVSLDKVHAKTLGETGGIGTVATRADIIEKLFNMFYIEKNGKDIIPTSKGKQVIDLVPSELKSPLLTAEWELELERISKGQKDSRGFIEAMRKYAAELVDDVKGSSDKFKHDNLTGKKCPDCGKYMLEVKGKQGRMLVCQDRECGHRENLARITNARCPECKKKLELRGQGEGKIYVCPGSNCNFREKASQFEKRFDSKSDKLNKREVAKIMNKLNQEKEDPMDSPFADLMNMFKDKK
(979) DNA topoisomerase 1 [Clostridium cf. saccharolyticum K10]
1
MAKNLVIVESPAKVKTIKKFLGSNYEVDASNGHVRDMPKSQMGIDIEHGYEPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLSKALKLEDCKDKKVYRITFNEITKNAVKAALKTPRAIDMNLVDAQQARRVLDRMIGYRISPLLWAKVKRGLSAGRVQSVALRMICDREEEISSFIPEEYWNLEAKLKAKGSKKKLTAKFYGTREGRMAIHKKEELEAVTAALEGAQYTVDEVKTGERVKKAPIPFTTSTLQQEASKTLNFSTQKTMRLAQQLYEGVDIEGKGTIGLITYLRTDSTRVAEEADKTAREFIEEKYGKQYVSTEEAVKKGGAKIQDAHEAIRPTDISLTPAVVKESLARDLFRLYQLIWKRFAASRMQAAVYETTSVRVAAGYAGGEYLFTLSASKLKFDGFMSVYVQEDEKEESTVLSEKLEKGDVLACEALESSQHFTQPPAHYTEASLVKALEEQGIGRPSTYAPTITTILARRYVVKENKNLYVTELGEVVNRMMKKAFPSIVDTAFTANMEYLLDRIGDGTVQWKTVIENFYPDLEEAVKEAEKKLEAVKIADEVSDVPCDLCGRMMVIKYGPHGKFLACPGFPECRNTKPYLEKIGVACPKCGKEIVIRKTKKGRKYYGCENNPECDFMSWQKPSAERCPECGGLMVEKGNKLLCTNKECGYVKTKENRQQQE
(633) DNA topoisomerase [Clostridium cf. saccharolyticum K10]
7
MKLVIAEKPSVGAAIAAVLGANEKRSGYFEGSGYLVSWCIGHLISLADAATYNEQYRKWKYDDLPIVPQDWQFTVASGKEQQFSVLKDLMHRSDVSEIVNACDSGREGELIFRFVYEQANCKKPFSRLWISSMEESAIREGFSNLKDGRSYDDLYQSALCRAKADWLVGINATRLFSILYHKTLNVGRVQTPTLTMLVNRDYAISSFKKEKYHVVRLNAGGVSALSERLNDEAAAQQMKAACEKSQAVCTSLKKEKKTVSPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYPRTDSKYITSDMQDSTKELITGLCSLLPFMRDVKLQADLTRVCDNSKVTDHHAILPTAEFLKAGFSSLADSETKLMTLVCAKLLCAAAAPYEYEAVTAAISCGGYTFTAKGKTTLCEGWCEIEKLSRAASEEQDEDAEPETVLPPLAEGQTFDNPAAEISERYTQPPKAYTEDTLLSAMENAGKEETPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLAAILPEVLTSPQLTAEWETRLTGIAKGSDSPDDFMRSIEEMTAGLVKTYSAISEDKAKLFTPQREAIGTCPRCGAAVYEGKKNYYCSDRACSFVMWKNDLFFQQRKKTFTKAIAAALLKDRKVKIKGMYSTKTGKTFDGVVLLADTGGKYVNFRVEQNRK
(1740) DNA topoisomerase III, bacteria and conjugative plasmid [Clostridium cf. saccharolyticum K10]
7
MRLVIAEKPSVAKSLATVLGAATRKDGYLEGNGWLVSWCLGHLAGLADAATYNPDYAKWRYDDLPILPETWRFTIAKDKRDQFDVLRTLLRREDVTEVVNACDAGREGELIFRTVYCLAGCQKPMKRLWISSMEDSAIREGFAHLRPGADYDGLHQAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDAFKPVPFYTVALDLPGFTAASARMDKKADAEQLKNACQSGTVTVKQVARRDKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQNLYEKKLCTYPRTDSRYLTSDMAEGLPVLVNLVANAMPFRKGIAISCDAAAVINDKKVTDHHAVIPTRNIREADLSALPVGERAILELVALRLLCAVAHPYIYDETSVTVECAGAEFTAKGRTVKQPGWRALDAAYRASMKNAEPDKETEDKALPELAEGQELPVAGAAVKEGKTTPPKHFTEDTLLSAMETAGAKDMPEDAERKGLGTPATRAGILEKLVSTGFLERKKSKKTVQLLPSHDAISLITVLPEQLQSPLLTAEWEYRLGEIERGELAPEDFMAEITAMLKELVGTYQVIKGSEYLFAPPREVVGKCPRCGGEIAEMQKGFFCQDKSCKFAIWKNSKWWAAKRKQPTKAIVAALLKDGRARVTGLYSEKSGKTYDATVVLEDTGQYVNFKLEFDRQKGGGK
(871) DNA topoisomerase [Clostridium cf. saccharolyticum K10]
3
MAKALYIAEKPSVAQEFANALKISGRRADGYIESETAVVTWCVGHLVTMSYPEEYDIKYKRWSLETLPFLPAEFKYQVIDGVKKQFQTVSTLLNRSDIDTIYVCTDSGREGEYIYRLVAQMAGVHGKKEKRVWIDSQTEEEILRGIREAKELKEYDNLAASAYLRAKEDYLMGINFSRALTLKYGPSISSFLRSKWTVVSVGRVMTCVLGMVVRREREIRNFVKTPFYRVIGTFTRESMKISAEWRAVQGSRYFQSPFLYRENGFKEREKAEELIAWLSAEGPVTGTVFSVEKKKETKNPPLLYNLAELQNDCSKMFKISPDQTLKIVQELYERKLVTYPRTDARVLSTAVAKEIGKNLSGLKGFSPCASFAAEVLQGTAWKTIAKTRYVNDKQITDHYAIIPTGQTGAVRNLPSLNAKVYELIVRRFLSIFYPPAVYRKYSLEIAAKTEHFFANFKILKEPGYLKVADVSGIRKKDENAEGTKDTAGAAGESSGEQSAGDSRQEETVIGDEAFAAMLEKLKKGMTLDLSGLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLMSISYLSLNPKTQVITPTLLGELIYEVVNASIRQLLNPELTASWEKGLTYVAEGSITEKEYMEKLERFVAGRTYGAVHTANQAGLRRQFELAAASYKGAEKLPGKGAASAEKAGKNVKNSRKKSAKTGGTINEKN
(268) DNA topoisomerase 3 [Clostridium cf. saccharolyticum K10]
2
MKSLVIAEKPSVGKDIARVLGCRKSADGCLEGDKYIVTWAFGHLVELAAPEEYDKKYKDWNMADLPMMPEPFKLEVIGKTAKQFGVVKRQLFRNDVKDIVIATDAGREGELVARFILMKAGCRKPLKRLWISSVTDRAIKEGFSRLRDGREYNHLRDAAMCRAEADWLVGLNATRALTCKYNAQLSCGRVQTPTLAIIAKREEEIRNFRPKAYWGLTARTSKPALTLTWQDKKSGGMRSFDRDRMEGLQKSLRDQQVRITKVKKTPKKTMAPLLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDVADTIHDRLAACGTGPYRKLAGKLSKNVWTKKASFINDGKVTDHHAIIPTEQFVQLQNMTSEERKIYDLVVRRFLAVLYPAAEYDETVITAEIGGEIFTARGKVMRTPGWREVYESADESGLSGTGGYLDEEDGDEDGEGPQNEERVKAQTLPDLREGDVTGPAGISLTEGKTKPPAPFNEAALLSAMENPVRYMESGDRAMAKTLGETGGLGTVATRADIIEKLFSGFMLEKKGKDICLTSKAKQLLRLVPEDLRKPELTAQWEMRLSKIAEGEMKRDAFMEDIRTYTKDIVEEIKGGEGTFRHDNLTNTKCPRCGKRMLSVKGKNSQMLVCQDRECGYRETISRTSNARCPKCHKKMELRGKGENQMFSCVCGYKEKLSNFKERRQREGAGVTKRDVARYLNQQKKEEKMVNNPFADALKKMQEQDV
(1502) DNA topoisomerase 1 [Alicyclobacillus acidocaldarius subsp. acidocaldarius Tc-4-1]
1
MSDYLVIVESPAKAKTIGKYLGSKYTVKASMGHVRDLPKSQLGVDVEHGFEPKYITIRGKGDVIKALREASKKAKKVYLAADPDREGEAIAWHLQHLLDLNPDDDCRVVFHEITKDAVKQAFQHPRKINLDLVNAQQTRRILDRLVGYKLSPLLWRKVKKGLSAGRVQSVALRLIVDRENEIRAFQPEEYWTVDAHGQVHGKKLVARFHGYGEEKTPLPNEEAVRELLARVEGHSLVVRRVRKSERKRNPAAPFTTSSLQQEAARKLGFRAYKTMQIAQQLYEGLDVPGEGTVGLITYMRTDSTRIAQSAQEEARAYIRQSFGEDYVPDRPRQYAKNEDAQDAHEAIRPTSVMRHPDRLKDHLSRDQYRLYKLIWERFVASQMESAILDTTSVDLEANGAWFRATGSVVRFPGFMALYTEGRDDESEEEEGKLLPPLEEGDVVQVKTWKPEQHFTQPPPRYTESSLVKAMEELGIGRPSTYAPTIDILLKRGYVTLDQKRFVPTELGEIVVNILKEHFPQLIDVSFTADMESRLDKVEEGHANWIELLDQFYHDFEKDLKKAESALGHVELKEEVSDVRCEKCGRLMVYKTGKYGKFLACPGFPECRNTKPVLKEISVSCPKCGKPLVERRGKSRKVFYGCSGYPECDYVLWQRPTGQVCPVCGHPMVEKGGKGKTVVVCSNEKAHPMVATEAQAK
(111) DNA topoisomerase III [Lysinibacillus sphaericus C3-41]
7
MKIVIAAKPDQAAKLAAPWSFTIKTGYFEVKANSYFPNGAIITWATGHLCELKTPEEYDSTWKKWKLETLPIIPDRFEYKVSKSKYKQFTIIKNLVKRADIQEIIIGGDAGREGELIIRTILRVCGVNKPMKRLWISSLTENSVKNGFSNLLPEAQTKDIYYEALSRSCADWLIGINTSRLYTVLLKKNGVKDVFSIGRVQTPTLALIVHREHEIANFKSEPFWEVEAVFHFAGKMLKAKWHKNNMSRVLEEKQAIAIANFCLHKNVDITKIIKETKEYAPPLLFNLSGLQATANKAYKFSPQKTLDILQKLYVKGLVSYPRSDSQFLTSEEAKTLPTILNNLSKMDKYKNLLPPPINSIMHNKRYVNEKKVTDHHAIIVTEQMPNLSKLSMEEEKIYDLVARQVIAAHYNHAIFAYTTIHSLVDKRAEFISKGKEQIEEGWRKVIYPTKDSSSQEEEEMLPLLHENELGTVAQASVKQGATQPPNRYSEGHLITLMKTAGKHLDDAELEKVLSKTEGLGTEATRAGIIGTLKDRQYIEIKKNQVFATSKGMLLIEALGENSLLTSPSMTAKWEQRLAEIGEGHASPQAFMEQVKKLTYKLITDAHEREKAWTFDQKEVEKISANNPYQKKYKKEKTVVGKCILCNGSIIDHGTFYGCSNYKAANCKFSVSKKILSKTISQTNVRKLLATGETDMIKGFKKGQKTFNAHLIWDKQEHRVHFKFPQ
(1855) DNA topoisomerase 3 [Lysinibacillus sphaericus C3-41]
2
MLYMAKSLVLAEKPSVARDIANVLKCHKKGNGYIEGDKYIVTWALGHLVTLADPESYDEKYKKWNLEDLPMLPERLKLTTIKQTSKQYNAVKSQLTRNDVNEIIIATDAGREGELVARWIIDRAKVNKPIKRLWISSVTDKAIKDGFANLKPGKNYDNLYQAAVARSEADWYLGLNSSRALSTKFNAQLNTGRVQTPVVAMVAAREDEIKNFKAQTFYGIEAQTKELKLTWQDASGNSRSFSKEKVDAIVNSLDKQDAKVIEIERKPKKSFSPGLYDLTELQRDANKIFGYSAKETLNIMQKLYESHKVLTYPRTDSRYLSSDIVSTLPERLKACGIGEYRTLANKVLSKPIKANKSFVDDSKVSDHHAIIPTEEYVNFANFTDKERKIYDLVVKRFLAVLFPAYEYEQLTVQGQIGNEKFIARGKTVISAGWKEVYSNRFDDEESSEDVKEQLLPRLEKGQVLKVNLITQTSGQTKPPARFTEATLLSAMENPTKYMNTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPNELKSPETTAEWEQKLELIAKGKLKKETFINEMKQHTKEIVADIKNSDKRFKHDNISTKTCPDCGKPMLEVNGKKGKILVCQDRECGHRKNVSRVTNARCPQCKKKLELRGEGDGQIFVCKCGYREKLSAFEARRKKEGGGKVDKRSVQKYMKQQEKEAEPLNNAFADLLKGFNVDK
(1308) DNA topoisomerase 1 [Streptococcus gallolyticus UCN34]
1
MATTTTTKAPTAVKKSSKKTTKKKTAAKKNLVIVESPAKAKTIEKYLGRNYKVVASVGHIRDLKKSSMSIDFENNYEPQYINIRGKGPLINDLKKEAKKSKKVYLASDPDREGEAISWHLAHILDLDENDKNRVVFNEITKDAVKNAFVEPRQIDMDLVDAQQARRVLDRIVGYSISPLLWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWTIDGFFKKGTKKFQASFYGIDGKKLKLETNEDVQKVLALLTSDEFTVAKVEKKERRRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGISLGKSGTQGLITYMRTDSTRISPIAQNDAANFITERFGEKYSKHGSRVKNASGAQDAHEAIRPSNVNLTPESIAKHLDKDQLKLYTLIWNRFVASQMTAAVFDTMKVNLELNSVRFTANGSQVKFDGYLAVYNDSDKNKMLPDMVEGDIVKKVSTNPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTLDVIQRRYYVRLAAKRFEPTELGEIVNNLIVEFFPDIVDVKFTADMEGKLDEVEEGKQQWQKVIDEFYKPFEKELAKAETEIEKIQIKDEPAGFDCDLCGHPMVIKLGRYGKFYACSNFPECHNTKAITKEIGVTCPVCGKGQVIERKTKRNRIFYGCDRYPECEFTSWDKPVGRSCPKSGDFLVEKKIRGGGKQVVCSNEECDYEEAKIK
(784) DNA topoisomerase [Streptococcus gallolyticus UCN34]
3
MVSSLKYLLLAEKPDQAKKYATALGNPKNEKGVWRVQSSVLNAEVIVAPAVGHLVERINPYTNFENWEMTNLPALPEGFSYEPKKDTIKRFNAIKKAVKEVDAIIIGTDPDREGEAIAYRILELIPEALRKIKYRLWANSLTKRGLEQAFANLRSPTDSINYFHEADARSDADWLVGFNLSPFVTIKMKEEGYLDKKDHSMSVGRVQTPIVSLIVRNDEAIENFKPSPYWRLKLIDSEAEVIFSNDIKYQSQMEAEQVLQQLANTAVVKTVTSEEKAQEAPKLYNLTNLQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTNEFSYLVDHIEEYQKAINKQLETPNRSPRKNYVNDKKVLEHYAIIPTENIPDLSELSDDEKLIYQKAVFRTLLMFTPDYRYQSTSVILDNHGLEFKATGTVTKDKGWRGYFAVKKEDKELPHYQEGQEVIVDCNLLEEMTKPPTRITEQILLKKLLPKYHLGTSATRDGMIDLIQDKGYVTKHKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFVNKIKWAITKQIEKGKQL
(882) DNA topoisomerase [Megamonas hypermegale ART12/1]
1
MASMGHLRDLPKSQFGIDVENDFAPKYINIRGKGDLIKSLKKEAKKSEKVYLASDPDREGEAIAWHLSHILGIDEHEKCRIVFNEITKPAIQEAVKNPKEINIDRVDAQQARRMLDRIVGYKLSPLLWKKIRKGLSAGRVQSVTVKLICDREKEIQKFESEEYWTVDFKFKKKPRSSMFGAELVAIDDKKLMVSAKKEDVKIASKAQADELCSDIEKVTFKVTEIKKRQRHRKAPAPFTTSSLQQDAARKLGFTSRKTMMIAQQLYEGISLGKKGPTGLITYMRTDSTRISEIALNEARNYIEENFGKEYLPEKPYIYAAGKSSQDAHEAVRPTNIALSPATVEEYLSKEQLKLYKLIWQRFLGCQMLPASYDVMSVTIKGDKYLAKATGSQLKFAGFTAVYNDSDNKKKKMSSCQICKKAMNYLFKN
(395) DNA topoisomerase [Heliobacterium modesticaldum Ice1]
7
MKTLIIAEKPSAAEAIAEAVAGTYQKKRGYLESPDFYITWAVGHLVQLAEPEDYRSSLKRWRFGDLPIIPDFQLRPVKKTEGQLKTIAGLAKKSRALINACDAAREGELIFRYIVAYLRLEEMPAWRLWTASLTAEAIRAAMADLKPLDRYDNLFKSARCRSEGDWLIGINATRAFTTRFGELLTLGRVQTPVLAMICENRRRRDAFVPETYWEVWARFRGEGCDYRGLWLREKGEAHRLNEKGKAEAIAAAVDGRNGEVRQVDEKESRELPPRLYDLTTLQRECNRLFGFSANKTLKIAQELYDSKFITYPRTNSRFVDKHGLALLRRVVSGLASHPVYGPFVAQGNPQLVHERNRNICRPEAVEDHHALLPTTLVPTGLVGDKWKVYDRIVRRVLAHYYLPARYRERVVLTVVPFERITGKATDLPVGDLGMATAVLDSAHSKEADDLGGAVFRSAEKTIIDPGWKVVDGGWTPPKEQERFPERAGLAVRCAGAEVLEKQTEPPKAYTEGSLLAAMETAGKQLDDEELREIMKDAGLGTPATRAATIERLKEVGYIELQGRQIEPTPKGMALISLVEKSEIPLLLSAEMTGRWEKFLNEIARGNAQPLEFNRRVSDLAVYLVKQLEAAEKSWYDKSACARRLGTCPRCGGAIVENRKAYVCANWKVEQCPVTIWKTFRGKGITEKTALALLEKGRSPRLRFYTKEKKPYPAVIVFDAQTGVMNLEFSSAATRSTKSARPKKATPAAEPVEPAERDRSTNTAKTLQPSNSGNQTASMKKA
(119) DNA topoisomerase 1 [Heliobacterium modesticaldum Ice1]
1
MSNKVLVIVESPAKAKTIGKFLGRRYQVKASMGHVRDLPKSQFGVDVDGGFNPKYITIRGKGELLKELRTAAKKSDQILLGPDPDREGEAIAWHLAQVLGVDEHTPCRIEFNEITKSAIQKAVKKPRPIDTNRVEAQQARRILDRLVGYNLSPLLWRKIRKGLSAGRVQSVAVRLISDREEEINDFTPDEYWSLTAELKAVKGNLQARLVRQDENKLEIKSREEMDRILGELAGQVFAVSEVKRKEKRRNPSPPFTTSSLQQEAYRKLGFTARKTMMIAQQLYEGLDLGKEGTVGLVTYIRTDSVRVSDGAVEEVRQHIQTRFGSDYLPAEPRVYENKGKIQNAHEAIRPTSVTREPETLKAVVTNDQYKLYKLIYERFISSQMSSAIMDTTTIEIKAGAFGFRASGAVLKFPGFMKVYIEGRDDDSKEEEGLLPEVSVDEKLDLQKLEPKQHFTQPPPRYSEATLVRALEERGIGRPSTYAPIIETIVARGYVVREDKQFYLTELGEVVVDLLKEHFPDIIDVEFTADMEAKLDAIEEGAADWRRILRDFYEPFRETLEEAEEKIGEIEIADEVTDQRCEVCGANLVIKQGRFGRFLACPRFPECRFTKPLLEEIGVPCPKCDGHVVIRRTKKGRKFFGCANYPECDYVSWERPTNVPCPLCDKPLVQKESKKLGTRRVCITEGCGYEEAVSDGEKGASTGWPVGDPRAQGGPGERRELAEPGVP
(326) DNA topoisomerase [Clostridium novyi NT]
3
MEKSLFITEKPSVAMEFVKLLNIKETKKDGFIESDNAIFTWCVGHMVTMSYPEAYDENLKIWSLKTIPFLPKEFKYELIPSVLKQFNVVKSLMLREDVKTIYVCTDSGREGEYIYRLVDMMVGVEGKDKKRVWIDSQTEEEIKRGIKEAKPLSEYDSLSDSAYLRAKEDYLLGINFSRLLTLIYGKTVSNIIGEDRVVIAVGRVMSCVLGMIVERELQIRNFEKTPFYKINGSIEIEENLGYECEFKAIEKSKYFESPKLYNDGGFKEKKDAEKLIEEIRIESKDNTAIIEKISKKKETKNPPLLFNLAELQNECSKNFKISPDETLNIIQELYEKKMLTYPRTDARVLSTAIAKEINKTISKLLRFKENEKVNNACKNILEKKLYVGLEKTKYVDDKKITDHYAIIPTGEGLESYRSLKPFQRNIYDLVVRRFLAIFYPPAIYSKITVETKIGEEYFFTTEKVCVTRGYLDILEEAQKDEKEKNLDFLNKLKKGTIVKIDELTIKEGKTSPPKRYTSGSIIIAMENAGKLIEDDELREQIKGSGIGTSATRAEILKKLERIEYIKVNNKTQIITSTTKGEVIYRVIRSSMPSLLNPKLTASWEKGLSMVVDREITPEVFMNKLENYINKNISNVVDNNRVINTNYLISGLEENNKKKIDEEKIDDVLGVCPICKKGTIVKNNKGYGCNNWKEGCKFFVAEICGVKIPVGEIKNLIKYGKTNIINGFKSKKGNEFRARLILKDNKVQLSFD
(613) DNA topoisomerase 3 [Clostridium novyi NT]
2
MGKILILAEKPSVGRDIARVLNCKKGGNGFLEGDKYIVTWALGHLVTLADPEAYDNKYKSWNIEDLPMIPKHLKLVVIKKSGKQFNTVKAQMNRKDVGEIVIATDAGREGELVARWIIEKAHIKKPIKRLWISSVTDKAIKDGFKNLKDGREYNNLYKSAIARAEADWLVGINATRALTCKYNAQLSCGRVQTPTIAMIAQREEEIKNFKPKTYYGIEAKSDKLKLVWQDSRSNDIKTFNKDKCENIIKNIKNKDAKVVEVNKVKKKKFSPQLYDLTELQRDANKIFNFSAKETLSIMQRLYENHKVLTYPRTDSRYLTEDVVDTIKDRLKACGVGVYGKYANKLLKGTIKGNKSFVDNTKVSDHHAIIPTEQKFALASLSDNERKIYDLVVKRFFAVLYPPFEYEKTTIKAKIGEENFIAKGKVVLANGWKEVYSNDFEDDMEDELKEQILPSINKGDSIKINSISKTTGETKPPKPFNEATLLSAMENPVKYMSGESKELKKTIGETGGIGTVATRADIIEKLFNTFLIEKRGKDIFITSKGKQLLDLVPEELKSPALTAEWEQKLTAISKGKLNKDKFLSEIKDYSKDTVNEIKNSKEKFKHDNMTRVKCPECGKYMLEVNGKKGKILVCQDRECGYRKGISRISNARCPECHKKLELRGEGEGQIFVCKCGYREKLSAFKERKKKDSGKVSKREVNKYLRQQQKENDEPFNNPFAEAFKKLGLK
(122) DNA topoisomerase 1 [Clostridium novyi NT]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVTASMGHVRDLPKSQLGVDIENNYNPKYITIRGKGELLSSLRKQAKKSDKVFLATDPDREGEAISWHLAEALKIDENEECRIEFNEITKNAIKSAIKNPRRLNLNLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMICDRENEIKEFNPKEYWTIECELKNEKSKKSFTVKLVSKNNEKIEINNEEESNSIIKELKQNKYIVKSIKKSEKHKKPLPPFTTSTFQQDSYKKLNFSTKKSMSVAQQLYEGIDIKGKGTIGLITYMRTDSVRISDEAQKNARQFITENFGQNYVPESIRNFKGKKNIQDAHEAIRPTYIELAPDEIKDNLKPDQFKIYNLIWKRFMASQMADCIMDTMSININNGQYTLRVSGSNIKFDGFKKVYKYEEDEESLKFPVLEENEILQDKKVEGKQHFTQPPARFSEATLVKTLEENGIGRPSTYAPIVSTLLDRKYIEREKKTLTPTELGFIVNNIVSEYFKQIVDVEFTAEMESKLDNIEEGKEKWKDVVNEFYSPLIECINIAEKEIAKIKIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVKELDVPCPVCGGKILLRKSRKGRKFYGCSNYPECNFVSWSEPVKDKCPNCGSYMVKKQSKSKGNYIECSNKECKTKIQQENQNVEK
(518) DNA topoisomerase 1 [Clostridium clariflavum DSM 19732]
1
MADKLVIVESPAKAHTISKFLGKDYKIIASVGHVRDLPKSQMGVDIENNFEPKYITIRGKGDVISKLKKEAKNAKKIYLATDPDREGEAISWHLAYLLNIDSKEKCRVTFNEITKNAVKNAMKEPREINLDLVNAQQARRILDRIVGYKISPILWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTIDAVLQKKDEKGSFNAKFYGKDGKKMELKSEDDVKRILENIKGKPFIVQKIKKGEKKKSPAPPFITSTMQQEAARKLGFSTKKTMIVAQQLYEGIDIKGVGALGLVTYIRTDSTRISDEAQQDVIQFIKEKYGEKYLPTEKRVFKNKNASQDAHECIRPSQVNMDPDSIKDSLTKDQYKLYKLIWSRFVSSQMASAEYDTISTDITIGDYTFKANGQMLKFPGFTVLYQESKDEEGEEKENDIPDLIEGEELKQKKIEPKQHFTQPPPRYTEASLVKTLEEKGIGRPSTYAPIITTILARGYVVKDGKTLMPTELGKIVNDIMKTYFQDIVDVEFTAQLEKKLDDIEEGYKKWVDVMQSFYSPFAKVLEEAEEKIGNVEVPDEVTDEICEKCGRNMVIKMSRFGKFLACPGFPECRNARPILEEAGVKCPKCGGKVYIKKSKKGKKYLGCENNPTCSFMSWDMPSKESCPKCGNFLLKKYLGKKVQLKCSNEECDFIKDGERKKEE
(1087) DNA topoisomerase [Clostridium clariflavum DSM 19732]
7
MGKNLYITEKPSVAASFAAVLGVNISKSDRTRGYAESKDSVVTWCFGHLITLALPDAYNDAYKEWKVEHLPIIPEEYKYVVIDDEGIKKQFETVKSLMLREDIDYIYACTDSGREGEYIFRLVYEHSGTTKPAKRVWISSQTEEAIKEGIKNAKDISHYDSLAQAAYSRAKEDWLFGMNFSRIYTCLYGRHLSALLKESRSSVIAIGRVMTCVLGLVTDREKEIRNFVPKTHYGITANFISMDNKIEYKGKWVPEKSKIIKFADDAQDEERYISKQEAEEVIEKLKGKEGKVKKVEIKSKNEQPPLLFNLAELQSEANKKFKLPVDKTLETAQSLYEKKLITYPRTDCRVLSTDVVGELPKVLNGLYMNPEYKGFVSRIKDFGELKITKSTKRYVDDSKVTDHYALIPTYVTADLNRLSENERKIYNLIVKRFLAIFYPPAVYNTVKVETEIDGEVFVTSSRTLKEAGWKEVYEVSKSKDEEDLTEVPIHLLSKNEGCETKNFELEEKETKPPPRYTAGSLIITMEKAGKFIEDEELREQIKTCGIGTSATRAGIIKKLKDIGYINIDSKTQVVTPTLKGEAIVELVRRTAKELLSPSLTASWEKGLAMIENKETTQEIFEKKLCDYINKTIQKVKKSNSDNSINLIRMFKDVI
(1837) DNA topoisomerase 1 [Bacillus pumilus SAFR-032]
1
MADYLVIVESPAKAKTIERYLGKKYKVKASMGHIRDLPKSQLGVDTEHDFEPRYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDLSSDCRVVFNEITKDAIKDSFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDRENEINEFKPEEYWTIDGTFLKGKESFEASFFGVNGKKHPLKTKEDVKEILSKLKGSKFSVEKVTKKERKRNPAVPFTTSTLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISNTAIEEVSAFIDQTYGKNFLNTTKRTVKKNENAQDAHEAIRPTSTLRKPADVKHVLSRDQLRLYKLIWERFVASQMAPAVLDTMSVDLDNNGLTFRANGSKVKFPGFMKVYVEGKDDQLEEKDKMLPDLKEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFIPTELGEIVLNLIIEFFPEIINVEFTAKMEKELDSVEEGTIEWVRIIDSFYQDFAKRVEKAEAEMQEVEIEPEYAGVDCEECGHPMVYKMGRYGKFMACSNFPDCRNTKPIVKDIGVKCPTCHEGNIVERKSKKRRIFYGCDRFPECEFVSWDKPIERKCPKCENMLVEKKLKKGMQVQCVNCDYKEEQQK
(1582) DNA topoisomerase 3 [Bacillus pumilus SAFR-032]
2
MSKTVVLAEKPSVGRDLARVLKCHKKGNGFLEGDQYIVTWALGHLVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVMKKTGKQFQAVKAQLARKDVKDIVIATDAGREGELVARWILEKAHVKKPLKRLWISSVTDKAIQEGFKRLKDGKEYDNLYRSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTIAMIFKREEDIQQFQPKPFYGLTAQVDGLTLTWQDAKTKQNRTFQENVIKERLAACKGKPAVVDALKKTAKKAFAPGLYDLTELQRDAHKRYGFSAKETLSTLQRLYEQHKLVTYPRTDSRFISADIVPTLKDRLKGMNVRPYAQHVNRILQSGVKAHKGFVNDAKVSDHHAIIPTEEELYPGVLSDKERKLYDLIAKRFLAVLMNPFEYEETTVITKIGSETFTAKGKTVQAAGWKAVYDDSYEEEESAEADQHLPLLSEGQSLDVRQLKETRGETKPPARFNEATLLSAMENPAAFMQNEEKDLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKGKDIFITSKGKQLLSLVPEDLKSPALTAEWEQKLSKIAKGQLKASQFMSEMKSYAKQAVSEIKQTNQTFKHDNVTGTHCPDCGKLMLKVNGKHGTMLVCQDRECGHRKNVAKKTNARCPNCHKKLELRGEGDGKIFACVCGHREKLSVFEKRKSQSNQKKASKHDVSKYMKKQKKVEEPINNALAEQLKKLKLDQ
(868) DNA topoisomerase 1 [Streptococcus pseudopneumoniae IS7493]
1
MATATKKKKSTVKKNLVIVESPAKAKTIEKYLGRNYKVLASVGHIRDLKKSSMSVDIENNYEPQYINIRGKGPLINDLKKEAKKANKVFLASDPDREGEAISWHLAHILNLDENDANRVVFNEITKDAVKNAFKEPRKIDMDLVDAQQARRVLDRLVGYSISPILWKKVKKGLSAGRVQSIALKLIIDRENEINAFQPEEYWTIDAIFKKGTKQFQASFYGVDGKKLKLTSNDEVKEVLSRLTSKDFSVDQVDKKERKRNAPLPYTTSSMQMDAANKINFRTRKTMMVAQQLYEGINIGSGVQGLITYMRTDSTRISPVAQNEAASFITDRFGSKYSKHGSKVKNASGAQDAHEAIRPSSVFNTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTMAVKLSQNGVQFAANGSQVKFDGYLAIYNDSDKNKMLPDMAVGDVVKQVNSKPEQHFTQPPARYSEATLIKTLEENGVGRPSTYAPTIETIQKRYYVRLAAKRFEPTELGEIVNKLIVEYFPDIVNVTFTAEMEGKLDDVEVGKEQWQRVIDAFYKPFSKEVAKAEEEMEKIQIKDEAAGFDCEVCGSPMVIKLGRFGKFYACSNFPDCRHTQAIVKEIGVECPSCHQGQIIERKTKRNRLFYGCNRYPECEFTSWDKPVGRDCPKCGNFLMEKKVRGGGKQIVCSKGDYEEEKIK
(843) DNA topoisomerase 1 [Lactobacillus sanfranciscensis TMW 1.1304]
1
MVESPAKAKTISKYLGRTYTVVASKGHIRDLPKSRMGIDIPDDFKPDYISIRGKGDTIKMLKAEAKKAKEVFLASDPDREGEAIAWHVSHVLNLDVNDKNRVTFNEITKETVKDALKHPRTIDMNLVDAQQARRIIDRLVGYSISPILWKKVKKGLSAGRVQSVALWIIIKREREIQAFNPEEYWTIDSIFKKGRSKFKASFYGVDGKKFPLGNNDDVQNVLKRLDAKADFEITDVKKREKKRQPPRPFTTSTLQQDANKKLHFKTGRTMMAAQQLYEGINIGKEGSQGLITYMRTDSTRISAGAKLEAAQFIHDEYGPEYALNHPRKLKLPEGAQDAHEAVRPTSVMRTPKQIEKYLTKDQFKLYNLIWSRFVASQMTPAIVDTETIKVVQNGVEYRANGSKLNFEGYLKAYSAGKKKDNILPDLEIGDHITLDNNVPNQHFTQPPARYTEASLIKALEENGVGRPSTYAPTLMTIQKRYYVKLDARRFVPTELGEIVNKLIEEYFPEIVNVDFTADIEGKLDDIEEAKLRWVKLVSEFYQPFSKEVSYAEKEMEDVQIKEPLAGFNCNICGSPMVEKMGKYGKFFACSRFPDCRNTQTIVKEIGVICPKCHEGQVIERKTKKNRLFYGCSRYPDCDFVTWDKPIGRDCPKCGHFLVNKKVRGGWQVICPEGDYEENAIK
(635) DNA topoisomerase [Filifactor alocis ATCC 35896]
7
MEHKLVIAEKPSVAISIAKVIGAKNKKDGYYEGNGYKVSWCVGHLIQMANPDAYDEKYAKWKIDDLPIITKEYKYEVAKATKKQFAVLKKLMNDKEIDTVINACDAGREGEAIFRLVYLQASCKKKMKRLWISSMEDSAIKDGFDNLKDGNVYDNLFESAQARAIADWLVGMNISRLYSCLYKQNYSVGRVQTPTLSMIVKRDDEIANFKKEKYYTVELELDGFTLSTERIDSLEVAEQLKNLLECRIEITDVIQTEKITKPDLPFDLTTLQRECNKHFGYSAKQTLDYAQSLYEKKLITYPRTDSRCLTEDMITSTVNNILGKNDFDTERIRVVFNSKKVTDHHAIIPTVSSMSEDLSSIPESEAKVYRLISNKLHASVGYPLIENTTKIVATFDGFEFTSSGKVIVDEGFTKYLKEYMSKKNEEPVLPEINVGDVLEIKEKEIKEKYTQAPKHFTENTLLKAMEIAGNDGLDKNVEVERKGLGTPATRAGIIENLIYKGFIERDKKNLIATNKGISLITIVADTFKSAETTAKWEMELSDISQGKSSKEEFLNTIEHEIRNELSHYKKE
(1412) DNA topoisomerase 1 [Filifactor alocis ATCC 35896]
1
MAKNLVIVESPAKAKTIEKFLGKKNYTVKASVGHIRDLPKSKLGVDVEQNFEPQYITIRGKGDIVKDLKKEAKKADFVYLATDQDREGEAISWHLAYLLDLDINDNNRITFNEITKDAIKKAIKSPRKIDLDLVDAQQARRIIDRLVGYKISPILWIKVRKGLSAGRVQSVSTRLIVEREEEIRAFTPEEYWTIDATVTGEDKRKAVFKLTEKNNKKIELHSEEETKLVLKDLHKKDMLIDKIDSKEKKRSAPKPFTTSLLQQEAGNKISFSSKRTMSAAQQLYEGVTVKGEGTVGLITYIRTDSQRISEEALASSKKYIEETFGKNYYQKYSSPKKKNSSIQDAHECIRPTSIYRTPESVKDSLTTDQYKLYKLIWERFVAASMSSAIFHTDTVLGSIDDYQFKVSGSTLVFDGFLKVYSYSKAEEQEIPNFVEKQYYKVNKLTDKQHFTQPPARYTEATLIKTLEELGIGRPSTYSPTISTILQREYVKKEKNFLIPTELGEIVTSIMKENFKNIVDVDFTADMEKQLDSVEEGTLPWKSVVEKIYTPLIEDVTVAEENLEKVLLQEKTDEKCPVCNEEMVVKYGRFGKFLACKNYPECTGTKPYLEKIGMPCPDCEDGEVIIRRSKKGRIFYGCSNFPNCSFVSWNRPTGKKCPECQENLVEKVTKKGTQIVCSSKTCSYKEEVKQ
(1631) DNA topoisomerase [Filifactor alocis ATCC 35896]
7
MKLVIAEKPSVALSISKIIGAKNKKDGYYEGNGYRVSWCVGHLIQMANPDSYDEKYAKWKIDDLPIIPSEYQYEVAKATKKQFAVLKKLMNDKAIDTVINACDAGREGEAIFRLVYLQASCKKKMKRLWISSMEDSAIKDGFDKLKDGKDYDNLFESAQARAVADWLVGMNISRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEITNFKKDKYYTVELSMNGFILSTERIDDEVAAEQLINLVGDKIEITDVIQKEKITKPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYPRTDSRCLTEDMITSTVNNILGKNDFDTGRIKTVFNSKKVTDHHAIIPTVSSLSEDLSGIPESEAKVYRLISNKLHASVGYPLVENTTKIVAEFDGFQFTSTGKVIKDEGFTKYLKEYKFNKNEDLELPDVSIGDVIIIENKEIKEKYTKPPKHFTEDTLLKAMELAGNDALEKGVEVEREGLGTPATRAGIIENLIYKEFIERDKKNLIATPKGKSLIEIVVDNFKSAEMTAQWEMELSEIAQGKSSKKEFLEKIEEQIKHTVEEHQKNE
(1372) DNA topoisomerase 1 [Natranaerobius thermophilus JW/NM-WN-LF]
1
MASNLVIVESPAKAQTIKRYLGKQYKVKASMGHLIDLPKSQMGIEINEVFKPKYITIRGKGKILSELKKEAKKADRVYLAGDPDREGEAICWHLGRALGIDEDEHCRVEFNEITKDAIKAAFKEPRKIAYNLVNAQQARRVLDRLVGYNISPILWKKVRKGLSAGRVQSVAVRLICDREQEIKEFVPEEYWTLIAQFSKDGEKFEGKLQEVDGKKAEIPNEERMNEILSKLENATYKVHKVEKKERKRNPNPPFITSTLQQDAYRRLGFSARRTMRTAQQLYEGIKVSGEGHVGLITYLRTDSTRISQSALTAAKEYILEEYGEDYYPGKPRTFKGGKGSQDAHECIRPTRTDLSPEKIKSALSNDQFKLYKLIWNRFIASQMAPAKYDTVAADIYAAGTMKFRARGSQLKFPGFLALGHEDQDKDEILPELKQDDLLDLEELQPNQHFTQPPPRYSEASLVKTLEKEGIGRPSTYAPIIETIQTKGYVIQEEKRLYPTQLGEIVVEQLKEFFPDVLDVDFTAEVEQGLDKIEDGEKDWQEFLYEFYEPFEKQVKTAEEEMKKIELEEEQTDVECEKCGSYMVVKHGRYGKFLACPNFPDCKNTKSFVKELNVECPKCQGTIVERKSKKGRKFLGCNNYPDCDFITWYKPVEGKKCPKCESFLVQRGKKNKYYQCSHPDCDYSADAVEEQEEKQS
(1210) DNA topoisomerase 1 [Roseburia intestinalis M50/1]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVVASNGHVRDLPKSQMGIDIENDFEPKYITIRGKGDILAKLRKEAKKADKVYLATDPDREGEAISWHLSQALKLDDKNAQRITFNEITQNAVKASLKEPRKIDMNLVDAQQTRRILDRLVGYEISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWTLDAELSVKGERKTLLAKFYGDENGKLTISSKEQADRIMAEMQKEEFHVLEVKKGERVKKAPLPFTTSTLQQEASKALNFPISKTMRIAQQLYEGVDVKGQGTVGLITYLRTDSVRISEEADAQAREYIAGNYGENYIAGEKTTKKNGAKIQDAHEAIRPSDINRTPVMVKESLSRDQFRLYQLIWKRFTASRMAQAVYETTNVKIGAGEYRFTVSASKIAFDGFMSVYTSDDDEKAENNVLVGSIDENTVLNLKEFDEKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTITTLLGRRYIVKEAKNLYVTELGEVVNQIMKESFPSIVDEHFTANMESLLDGVEEGNVNWKTVVRNFYPDLDEAVKAAQKDLEKVKIEDEVTDVICDVCGRNMVVKYGPHGKFLACPGFPECRNTKPYLEKIGVTCPKCGKEVVLRKTKKGRKYFGCEDNPECDFMSWSRPVAEKCPKCGGYMVIKGNKIVCADEQCGYVTDRKNVEKDSE
(1618) DNA topoisomerase 3 [Clostridium acetobutylicum ATCC 824]
2
MGKILVLAEKPSVARDLAKVLKANINKKTHLEGNKYVVIWALGHLVSLADPESYGEKYKKWSMDTLPMLPKNMKLSVLKNTSKHFYDIKKVMERKDLDELVIATDAGREGELVARWIIEMAKWKKPIKRLWISSQTDRAVRDGFAHLRDGRDYENLYKSAKCRSEADWFVGLNVTRALTCKYNAQLSAGRVQTPTLYMIVSREEEIRKFKPKDYYTIEGKVKSFSMNWHDKSGDFKIFNKERAEKIEALVKGSKGKIVDVSESKKKKYSPALYDLTELQRDANRFFGFSAKETLSIMQRLYENHKLLTYPRTDSRYIPHDVVATLPDRLRAISIGKYSKFAAEILRSKINVHKGFVDDSKVTDHYAIIPTEERPALGALSNEEFKIYDLVVKRFLSIMLPPFEYIQTTVKAEVAGEIFIAKGKVVKSKGWKEVYDKTEDFEEKSELKDQMLPEMNKGEDITFSTVSIKKGQTKPPSRFTEATLLSAMENPQRYVSMDKISAKTLGETGGLGTVATRADIIEKLYKTFYIEKKGNEIVPTSKGKQLVNLVPSDLKSPLLTAKWEGQLDAISKGKLNGVSFVNEIKGYASKLVDDVKGSKDTFKYDNLTGTKCPECGKYMLQVNGKKGRMLVCQDRECGHRENLAMFTNVRCPECHKKLELRGEGEGRIYVCPNCSFREKYSSFQKRFKGNNNKVNKREVSNYMKKMKKEAEAPINNAFADLMSMFKDKN
(1526) DNA topoisomerase 1 [Clostridium acetobutylicum ATCC 824]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIDDNYNPKYITIRGKGELLDKLKKAAKKCDKIYLATDPDREGEAISWHLSKVLKIDESEKCRIEFNEITKNAIKTAIKCPRKININLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMVCSREKLINDFKPEEYWSIDAQVYKQSKKDKFTIRLTSFKGKKIKINNEEENEQIINSIKKDEFKVENVKEGTKNKNTLPPFTTSTLQQDANKKLNFSTKKTMSVAQQLYEGIDVKGHGTIGLITYMRTDSVRVSKEAQEAANDYILNEYGKEYLPPSPKLYKSKKNIQDAHEAIRPTYIELTPGMVKSSLKDDQYKLYNLIWSRFMASQMANCILNTLSIEIKNGEYTFRASGSNVKFEGFMRVYKYNIEEDEHNEKIPLLQKGDLLHTDKIDGKQHFTQPPARFTEASLVKTLEENGIGRPSTYAPIISTLIDRKYVKKEKKAIFPTELGNIVDNILSDYFKQIIDIEFTADMENKLDNVEEGKENWKEIVDEYFKPLKEAIDIAEKEVAKITIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVEKLKVKCPKCGGDVIVRRSKKGRKFFGCSNYPDCDFVSWFEPTEENCPNCGSFMVKKFSKAKGYYLQCSNQECKYEKSNPDPDKK
(1386) DNA topoisomerase [Clostridium acetobutylicum ATCC 824]
7
MRKILVISEKPSVGRDIANVLGCKTRGEGCLIGAKYIVTWAVGHLVTLWEPEEYNAIYKKWRFDTLPIIPEVMKIKPIDGTKKQFNIIKKLMNDNSVESLICATDAGREGELIFRYTYEAAECKKPFSRLWISSMTDEAIKEGFSTIKPGTEYDNLYHSAKCRSEADWLVGMNASRAYTLKYNVLLSVGRVQTPTLAIIVKRQKEIDNFEPKDYWEVVSKYEGFNGTWFDKETKESKIMDKKKADDLGAKILGQTGKVISIENKKKKQVPPLLYDLTELQRDCNKKFGFSAQKTLDIVQSLYEKRKMVTYPRTDSRYLSHDMVNKIKKTIGRLNINPYDKYVGEILKLSKLPMGKRIIDDSKVTDHHAIIPTDVKPNLSTLTKDELKVYDAIVRRFLCVFYPNYEYTITKIVTEVVEENFLTQGKTILKLGWMEFYKHDKKEKDDENSEPDELPKLKKNESVQVKDSEIKAKKTKAPSSYTEASLLSAMENAGRFVEDEQLKEQLKDGGLGTPATRASIIERLIQVGYIQRKGKSLHPTDKGMKLIEIVPYELRSPETTGKWEKGLSSISKGKMASERFMQSIKRYVQYIIQESVKVNRSVVFQNNDSKFPQKNKQLPEAIGECPFCKRGKVYENSKAFYCSEWKGGCKFTTWKDSLKNYGIQVDKDLEKKLLKERVLYNVFGIEPKSGEKTVYTLKMNNYGAVIAKTQ
(303) DNA topoisomerase [Geobacillus thermodenitrificans NG80-2]
7
MKSLVLAEKPSVARDIARVLGCKKTHKSYLEGPRYIVTWALGHLVELKMPEDYDRKYETWRLEDLPIIPKKMGLKVIRQTSHQFRAIERLAKRRDVKDCIIATDAGREGELVARWILQKIDWKKPIWRLWISSQTDQAIRDGFRQLKPGTQFDRLYESAICRAEADWLIGLNVTRALTTKYNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIHARIGSVTAVWERHGGKRLFDKDEANELMTRLKGQPARVTSVKRKRKSEPVPLPYDLTELQREANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMKATMTDRLLAMKPGYEDVISSLLTKKNVKAANRVFQDDKVTDHHAIIPTDERLDLAKLSVDERKLYDMIARRFLALFYPPYEYETATVVFEIGDETFVARETAVVNAGFKAVLGKEETEAKPTLLHLSEGQTLASVQLEMEQSFTEPPSRYSEADLLAQMERYGLGTPATRADIIERLVETEVVERKDGRFYPTKKGKQLIELVNEELKSPELTARWERELEAIARGKGNPKQFLANIRRQTEQLVTEIKQSEQTYKAPNLTNLTCPECGSLLKERKTKDGRMLVCSNLECRYRRRRDPKLSNRRCPQCHRRMEMHEGKAGLYFQCRPCNIVEKAEETKRTSAKGTERALLKKYSPSNESFGTSLGELLKQALEKKE
(576) DNA topoisomerase [Geobacillus thermodenitrificans NG80-2]
7
MKVIIAEKPDQGATLASIFRTKKRQGYIEILPNDLFPDGAYMTWAIGHLCQLAPPERYRSEWKRWTLKALPIIPERFEYEVEKAKAKQFKVVKELLRKPEVKEIIHAGDAGREGELIVRNIIRLSGVNKPMKRLWLSSLTPKAIEEGFRRLLDERTTRPLYEEAYARACADWLVGMNASRAYSLLLKERGMNDVFSVGRVQTPTLALIVRREREIEQFRPEPFWEVVASFVIGDKQYEGKWIDENGQTRLKDEAMAKNIAAFCRGKQAVVADVRTDRKTFQPPLLFNLSTLQATANKLYRFSPKKTLDVLQSLYQKGIVSYPRSDSMHVTRGEAETFPAILQKLSAFSAYASYFPLPQPSILHNKRYVNEKKVTDHYAIIPTEQVVDPEKLSADERKVYDLIVRRLIAAHHQAAVIDYTTVATLVDGRARFITKGRQVIEEGWRAVIRPHEEEKETVLPLLCQGEAGEVADIQVKEGKTEPPKRYTEGQLITLMKTAGKFLDDEALEKVLAKTEGLGTEATRAAIITMLKERKYIEVKNNLVYATDKAKVLIEALGGTILASPEMTAKWEQRLSEIGEGAASSAAFMEQAKKLAQKVVADAIAAAPSWNFSGLDTASIQRTKTKKTVGEPLGRCPLCGGTVVDKGTLYGCDQYVKTSCSFTVSKRILGKSISAANMKKLLAKGKTNVIKGFKKGGKTFDAVLVWDENDKKLSFQFPKR
(74) DNA topoisomerase 1 [Geobacillus thermodenitrificans NG80-2]
1
MSDYLVIVESPTKAKTIERYLGKKYTVKASMGHVRDLPKSQMGVDINDGYTPKYITIRGKGQVIKELKTAAKKAKKVFLAADPDREGEAIAWHLANMLDLDIHSDCRVVFHEITKDAIKQSFQQPRSINMNLVDAQQARRVLDRLVGYNISPLLWKKVKKGLSAGRVQSVALRLIIDREKEIRQFQPEEYWTIQAKFQKGKEAFAASFYGVDGEKLELKTEADVKEVLARLNGRAFTVKTVTKRERRRSPVPPFTTSSLQQEAARKLNFRTKKTMMVAQQLYEGIDLGGEGTVGLITYMRTDSTRIAETAQQEAAAYIEATFGAQYVHQEKRKEKKSTNAQDAHEAIRPTSAFRDPDKVKPYLTRDQFRLYKLIWERFIASQMAAAVLDTMSVELENNGVLFRASGSKVKFPGFMKVYIEGTDDQTEEQDRLLPDLEEGEAVESEMIEPKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRNYVVLENKRFVPTELGEIVVELILEFFPEIIDVEFTAKMEKELDEIEEGKVEWIKVVDEFYREFEKRLKVAEKEMREVEIKDEPAGIDCDVCGSPMVYKMGRFGKFIACSNFPECRHTKPIVKEIGVKCPKCHEGNIVERNSKRKRVFYGCDRFPECDFVSWDKPLARPCPKCGGLLVEKKLKKGVQVQCTACDYEEQPEA
(910) DNA topoisomerase 1 [Lactobacillus kefiranofaciens ZW3]
1
MPTKVKSKTKTTKRNTKKRKKTLVIVESPAKAKTIEKYLGRNYHVIASKGHIRDLPKSQMGIDFEDNYKPKYISIRGKGDTIKELKSEAKKAKDVYLASDPDREGEAIAWHVAHALNLDEKAKNRVTFNEVTKDAVKESFKHPRTIDMDTVDAQQARRVLDRIVGYSLSPILWAKVKKGLSAGRVQSVALKLVIDREKEIKNFKPKEYWTIDAEFKKEKESFKSAFYGLNGKKTELANIDAVKDVLAKIDKKKDFTVEKVVSRQRRRQPAAPFTTSTMQQEANKRLGYRTRRTMSIAQQLYEGISLGKQGTVGLITYMRTDSKRTSPVAQKEASQFLHENYGAEFAAKSQRHFQNQEDAQDAHEAIRPTSVYRTPASLKSVLTTEQYRLYKLIWSRFLASEMTPAVYDTVRADIVQNGVIFRTTGSKMRFAGFTKVYDNQQEKNVDLPDLQEGDRVKMSKSDNKQHFTLPPARYTEASLVHALEENGVGRPSTYAPTIDTIQRRYYVKLEGRSIVPTELGEIVDTLIEQFFPDIANVDYTAHLENELDEVEDGQKEWTHVVDEYYQPFKQELNKADSEIEKIQIKDEPAGFNCDICGAPMVIKMGRYGKFYACSRFPDCRNTKPIVKKIGVTCPKCGKGEVVEKKSRRNRKFYGCSRYPECDFVSWDKPIGRNCPNDGHFLVEKKSKKGLTVLCPNGDYREEPQEGESNK
(1669) DNA topoisomerase 1 [Pediococcus pentosaceus ATCC 25745]
1
MPAAKKNLVIVESPSKAKTIEKYLGRTYKVVASLGHIRDLPKSKMGVDLENDYEPHYISIRGKGDTIKNLRKEAKKAKKVYLASDPDREGEAIAWHLSYLLGLDPKDQNRVVFNEITKDAVKNAFKTPRSIDMTLVDAQQARRILDRLVGYSISPLLWQKVKKGLSAGRVQSIALSLIIKREQEIKAFEPEEYWSIDSEFKKGRSKFKAAFYGVNNKKMKLPNNDKVQEVLKKIDPKADFDITEVKRRERKRYPAPAFTTSSMQQEANKTLNFRTRKTMMAAQQLYEGINIGKEGTVGLITYMRTDSTRISEVAKHETSLFIHDEFGAEYAATKPRKGKMPEGAQDAHEAIRPSSVLRTPESIKEYLNKDQFRLYNLIWSRFVASQMTPEVSDTMTVKIEQNGVQFRANGSKTKFEGFTKVYKTNKDKDNVLPNLEEGDQVQLVTNNPNQHFTQPPARYSEATLIKALEENGVGRPSTYAPTLDTIQRRYYVKLESKHFEPTELGEIVNEIIYDFFPDIVNIDFTAGLEKDLDSIEEDKEDWVKVVDRYYKPFAKELAKAQEQIEKVQIKDELAGFNCEICGSPMVVKMGRYGKFFACSRFPDCRNTQAIVKEIGVTCPKCHQGQIIERKSKRGRLFYGCSRYPDCDFVSWDKPIARECPVCHSYLIEKKIKGGKQIVCPNGDYEETPQK
Family distribution
Taxonomy tree
Firmicutes