Taxon : Clostridium

Informations

Name	Clostridium
Rank	genus
# topoisomerases	43

Lineage and sub-taxa

Lineage	Bacteria > Firmicutes > Clostridia > Clostridiales > Clostridiaceae > Clostridium
Sub-taxa

Topoisomerases

Name	Family	Sequence
(1123) DNA topoisomerase [Clostridium phytofermentans ISDg]	7	MKVGKFMGKSLYISEKPSVAQEFAKALKSNFRKSDGYMESEDSIVTWCVGHLVTMSYPESYDPALKKWSLQTIPFLPKEFKYEVIPSVSKQFQVVKGLLNRSDVDKIYVCTDSGREGEYIYRLVDQMAKVPKNKEKRRVWIDSQTEEEILRGIREAKPLSDYDNLSSSAYLRAQEDYLMGINFSRVLSLKYGYTVNNFLKNEKHSAIAVGRVMTCVLGMVVRREREIREFVKTPFYRVMLTLETSDRTFDGEFKAVEGSKYYLSPLLYKENGFREKQEAEKLITMLTGYESEYETRIENNNKNSYLAKLKQDEESKQLVAEIVSMEKKKENKNPPLLFNLAELQNECSKLFKISPDETLKYTQELYEKKLVTYPRTDARVLSTAVSKEIYKNIKGLTALSQFQPFAEEVLALGSYKNIAKTRYVNDKQITDHYAIIPTGQGFGALSSLSPTAKRVYVSIVKRFLSIFYPPAVYQKIAITTKIDTESFFSSFRVLIEEGYLKVAGYQGNTNTAMQDTDGSAKTSTKTEADGKEKGSDEETEEEKDYDATFFEVIKSLKKGMKLPVRNFTIKEGETAPPKRYNSGSLILAMENAGQLIDDEELRAQIKGSGIGTSATRAEILNKLVKINYLSLNKKTQIMTPALMGELIYDVVNVSIRSLLNAELTASWEKGLTMVSDGTITKDEYIAKLEGFVGRMTEGVKGVNNANLLIPYFEQVAQNYKK
(376) DNA topoisomerase 1 [Clostridium phytofermentans ISDg]	1	MPKYLVIVESPAKAKTIKKFLGNNYEVLASNGHVRDLPKSQMGIDVENGFEPKYITIRGKGDLLAKLRKEVKKADKVYLATDPDREGEAISWHLSQTLKLDDKSASRITFNEITKNAIKNSIKEARDIDMNLVDSQQARRMLDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREEEINDFVPKEYWNLDASFKVKGEKKSLVAKFYGDTKKKISIESKEEMDKILADLKGAQFKITEVKRGERQKKSPLPFTTSTLQQEAAKLLNFSTQKTMRIAQQLYEGVDVKGHGTIGLISYLRTDSIRVSEEADTAAREFIKTQYKPEYVNSQDVNKTTGKKIQDAHEAIRPTYVDLTPVIVKESLSREQFRLYQLIWKRFIASRMQPAKYETSTAKIDGNGYRFTVASSKLIFDGFMAVYASEDEEEENTTSNMMSLSEETQLTFEEFNSSQHFTQAPPHYTEAALVKTLEELGIGRPSTYAPTITTIIARRYVIKENKNLYVTELGEAVNRIMKQAFPTIVDVNFTVNLEALLDGVEDGVVNWKTVVSNFYPDLESAVQDAEKQLEQITIEDEKTDVICSECGRNMVIKYGPHGKFLACPGFPDCRNTKPYFEKIGVACPLCGSDIIIKKTKKGRRFYGCENNPECEFMSWQKPSGKLCPICNGIMVEKGQKLVCVNEGCGHVENKEQN
(180) DNA topoisomerase 1 [Clostridium sp. BNL1100]	1	MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAVKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATKMICDREDEIENFESQEYWSITAKLTKPKASPNFEARFYGIGKEKIELTNEEQVNSILDEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGFTTKRTMMVAQQLYEGIEIKGHGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPENPRVYKNKSASQDAHEAIRPTYMDMAPEGLKEFLSAEQYKLYKLIWDRFISSQMSSAIYDTVAADITAGKYMFKANGSKVKFPGFMVLYIEGNDVEGKDEDGEQNEKENNLPQLNEGDILELKKNTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAQMESELDDVEDGNKEWKAVMRDFYSSFAGVLKEAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNTKPIVEEAGVECPLCKGKVLIKKTKKGKKYIGCERNPECSFMSWDMPSPNKEMCPVCGAFMLQKSSGKKKALKCSNDKCTSNTETSTDTK
(250) DNA topoisomerase 3 [Clostridium sp. BNL1100]	2	MGFTLVIAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFSVQWQDGRTNQTRTFNKEEADGIVAKITGQIGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKISVTKRFVDNSKVTDHHAIIPTEQFVDLSSLNSEERNIYDLIVKRFIAVLSQPFEYEQTTVKLNVAGESFYAKGKIVRSSGWKTVYDGFGKLDEDSDEDDNDQSLPDIQKGHKAKVVAPKAINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERRGKEIYPTSKGTQLISLVPADLKSPELTAKWEQQLSLISKGKANSNAFVGEMKNYAKKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHVCPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGEQVDKKDVARFMRQQDKDESINSALADALAKWKK
(1328) DNA topoisomerase 1 [Clostridium ljungdahlii DSM 13528]	1	MGQKLVIVESPAKAKTIGKYLGKNYVVKASMGHVRDLPKSQLGVDIDNEYTPKYITIRGKGELLDKLRKEAKKSEKVYLATDPDREGEAISWHLSHALKLDENEKCRIEFHEITKNAVKSSIKSARLININLVNAQQARRVLDRLVGYKISPILWRKIKWGLSAGRVQSVALKMICEREKKIVDFVPQEYWTIECELHKENESKCFNVKLTTFNKKKIEIGSKDEVDKIIEELKQGQFIVKSIKNTNKNRTPLPPFTTSTLQQDAYKKLNFSTKRTMSIAQQIYEGVDIKGYGTIGLITYMRTDSVRIAQEAQEACRDFVANKFGKEYIEEKPRNFKSKKNIQDAHEAIRPTNVEITPEIAKENLKPEQYKLYNLIWNRFVASQMSSCQIDVKSIDIVNSNYGLKVSGSRIKFDGFMKVYKYATEEEKSDISLPKLEEGEKLLRKSIDGKQHFTQPPARFSEASLVKTLEENGIGRPSTYAPILSTLLDRKYIQREKKTLIPTELGDIVNNIVSQYFKQVVDVEFTAAMESKLDSVEDGKDDWRKVVGEFYEPLKKSIEIAEKEVARITIEDKVTDIKCDKCGRNMVIKHGRFGDFLACPGYPECKNTKPIVEELDVKCPKCQGKVLIKRSRKGRKFYGCSNYPDCDFVSWFEPTNEKCKECGNYMVKKYNKSKGNYLECSNSECKHREYKAVEDGDEKTAK
(151) DNA topoisomerase [Clostridium ljungdahlii DSM 13528]	3	MKSLIIAEKPSLAMSIVKSIGSMERNNGYFENKNYIVTFAYGHLLQLYDVDDYFGREKTKWTLKELPFVPKEFKFRLRKDEGVKKQYEIIKSLIKRNDVQEIVNCGDADREGEVIVNNIIFRAFEEEHVTKPVKRLWLPEQTRQTIIQSLKDLRDDIEYKNLYDEGLARTYLDWSYGINLTRYLSIKSGSFLPVGRVLIPIVKYVYDRDEKIENFKPETYFEIGAVINKDNLHIKTKLKDRKFAANERDKAEKLLNNLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKEEKMSLDDTLKNLQKLYEAGYTTYPRTNTEYLAENEKDRIKSVIAAVKENFNADISFKDNKKIFNSKKVESHSAITPTIKIPRKEKLSEGEKKVYTAIKNRFISNFLNEETIIEETSVVIKIDDEIIQLKGNVIKSPGFLKYEKSKRENELPQFVEGEELDTKLSVDQKETQKPGRVTESELNNFLKNPFKKQEVEDLEGENDDEEYKLILEGCEIGTVATRAGIIKNAKKYEYIKELKGHLECENKGKKLIEALEKLKIDLNKEKTVEFGKQLKKVYKEEIGINEIIDKVKDELNSIVQNGNKIKIEKLYLYNNKSDSKIKIESIGKCPVCHEGEVVENKSGYGCNRWKEGCKFFVGNKIAGKEILKTHVKKLIKDSKTNVIKGFKGKSGKKFNASLVIDKEGKIVFNFENEVLGKCPCCGHDIVEGKNAFGCSNWKEGCKFTIWKNDKYLACMGKKPTKTMVCELLKNGKVKIKGLKGKDGNIFDAYLMLIKNENENKDKYPYKWKMQITK
(22) DNA topoisomerase 3 [Clostridium ljungdahlii DSM 13528]	2	MGKILVLAEKPSVGREIARVLKCRKKGNGWLEGEKYIVTWALGHLVTLADPEAYDDKYKTWKLEDLPMLPKYLKLVVIKQTGKQFNAVKEQLNRKDVTEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAINEGFRNLKPSSQYDNLYRAAQCRAEADWIVGLNVTRALTCKHNAQLSAGRVQTPTLAMIVHREEEIKNFKPKDYYSIIGNANGYTLQWQNGNGHFNTFDENFANKVVSKVNGQNGKILDVIKSDKKKYAPALYDLTELQRDANRLFGYSAKQTLSIMQRLYENYKFLTYPRTDSRYISADIVPTLPERLKAISVGNYSKFAMEIMRGKIRAHKGFVDDSKVSDHHAIIPTEEKVILSKLSNEERKVYDLVVKRFLSVMLPPFEYVQTTVKAEINGENFAASGKVIKSKGWKAVYDKNEDFDDNDGLHENQLKEQVLPNLNRGDSIKLTAVKMHKGQTKPPARFNEGTLLSAMENPQKYINMNKEYAKTLGETGGLGTVATRADIIEKLFNTFYIEKKGKEIIPTSKGKQVVELVPEDLKSPLLTAKWETDLNLISKGKLNDKSFIGNMRNYSVKLVEDVKGSHDKFRHDNLSGAKCPECGKYMLEVNGKHGRMLVCQDRACGHRENLAKLTNARCPECHKKLELRGHGDGQVYVCINNNCNFREKASSFNKRFDNKQGKNSKRDVANYMKKMKKESEVPMNSALADALAKLKLK
(1037) DNA topoisomerase 1 [Clostridium tetani E88]	1	MIMGQKLIIVESPAKAKTIGKYLDKTYHVEASMGHIRDLPKSQLGVDIDNNYEPKYITIRGKGELLTKIKKHAKKCDEIYLATDPDREGEAISWHLSQALKLEDNKKCRIVFNEITKSAVKNAIKEPREIDIDLVNAQQARRVLDRLVGYKISPILWRKVRWGLSAGRVQSVVLKMICDREKEIEEFIPKEYWTIECKLNKDRKDFLVKLISKDNKKIEINTEEESNNIIKELKQGQFTVDKIKKTNKNKNPLPPFITSTLQQDAYRKLNFSTKKTMSVAQQLYEGIDIKGHGTVGLITYMRTDSVRISKEAQNKARQFLENVYGKEYIPEKPRDYKGKKNIQDAHEAIRPTNIEITPKIALENLNSDQYKLYSLIWNRFMASQMAACVMEVNSVDVKNSEYIFRATGSIVKFDGFMIIYEYLNEDEKENINIPKLEKGELLKEKSIDSKQHFTQPPGRFSEASLVKVLEDNGIGRPSTYAPIISTLLERTYIERENRTLKSTELGVIVNNIMVEYFKPVVDAEFTAEMENKLDSIEEGNENWKNTVDEFYSPLKELIETAEKEVEKVTLEEKVTDVKCEKCGNNMVVKHGRFGDFLACPGYPECKNTKPIVHQLDVKCPKCHGEIVLKKSKKGRKFYGCSNYPKCDFVSWFEPVERKCDVCGNYMVKRYTKAKGDYIECSNKECKHKIMPEKKQE
(405) DNA topoisomerase 3 [Clostridium tetani E88]	2	MGKTLVLAEKPSVGREIARVLKCNKNSRSYIESNKYVVTWALGHLVTLADPEVYDNKYKKWEMETLPMLPKYMKLCVIGKTSKQFNEVKKLMNRNDIDEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAIIDGFNNLKPGKDYENLYKSAVCRSEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLALIVEREEEIKNFKPRDYYNIVAKTKGIQFNWQDKKGQMATFNEDFANNILAKVSGEIGNVTEVIEKDKKQYAPALYDLTELQRDANRIFGYSAKETLSIMQRLYENHKVLTYPRTDSRYISKDIVATIPQRLKSISIGIYSKFAEEILRGKIVAHKGFVDDSKVSDHHAIIPTEERVKLSNLSGDERKIYDLVIKRFLSVMLPPFEYIQTTIKVEVNGEVFIAKGKNIKHNGWKAVYNKEDLNEDNNDGDGLKEQVLPQIIKGDAIKFNLVNINKGQTKPPARFNEGTLLSAMENPQKYIKLNKEYAKTLGETGGLGTVATRADIIEKLYNSFYIEKKGKEIIPTSKGKQIIDLVPQDLKSPILTAEWEKKLELISKGKISGKEFINNMRNYSTKLVQDVKNSNEKYIHNNLTGTKCPNCEKYMLEVNGKRGKILVCQDRECGYRENISRFTNVRCPECHKKLELRGEGEGQIYVCSKCTFREKLSSFNKRFKEKGNNADKREVSRYMKKMKEQDKEPMNSALADALAKLNLK
(1761) DNA topoisomerase [Clostridium tetani E88]	3	MNLAKVIIAEKPSVAKNIADALNIKTRKDGYFEGKEYLITWAFGHLLQLYDAKDYNEIMKGWRLEKFPFIPMNFKYKIKQQNNNKNITDEGAEKQINIIKSLIERENVEAIISATDLDREGQIIGDELFSYLQIKKPIYRLLLNEWTPDEVKNGMKNLKCNEDMKFLRDAGISRQWSDWIIGINLTSVATLKYNIEDNKILNIGRVILPTLKIIYDRDKEIENFKATTYYKLLANFKTKKDKEFEGTYYEKNSEKFQDKSYLKIIEDLLKNKTYNIVDKHVEKKKEYAPYLFNLSNLQGYVTSKYKGWTSDKVLKVAQSLYEKKFITYPRTSSSVLDESLEGRAKKVLETLKKGLSYENQIRFNKSKRIFDSSKVESHSAITPTYIKPSKLTRDEEIVYIAIKNRFIMQFMPIAEFEETKITIKANDEDVKGEFLSKGKVQIVEGWRIVEKIETKDTILPLVEVKEKVDAVNSKIKTVTKKPPKHHTEKTLLRVMETCGKSFKDDENSEEMMNAILSGFSIGTAATRADTIKKLKDIGYIEAKGKSLICAPLGRTMIEIFPVKELLDLEYTGKLEKTLSDIEKGKFGKKEFMDLIYEFTNRAVELIKSDNSMLNKIKINLPEGVENLGKCPQCGNPVIEGSKGYGCSNWKNGCKFTIWKNDKYIQSFGKKVTKDMVKILLEKGRVGFRNLKSKKGNVFTAYFTYENNKEKGYYSWKMHFIN
(557) DNA topoisomerase III-like protein [Clostridium perfringens str. 13]	3	MKKVIIAEKPSVARNIADAFNIKKRKDGYFEGEEYLITWAFGHLLQLFDAKDYDENMKGWRMEKFPFIPEVFKYKIKQDSLNRNIIDKGAEKQIKIIKGLIDREDVDGIISATDFDREGQVIADEIFLYFSEKKPVYRLLLNEWTPDEVKKGMEKLKPNEEMQSLQDAGIGRQWADWIIGINLTSVTTIKYKLNDGQILNIGRVLLPTLKIIYDRDKEIENFKSSAYYKLNGTFKTSKNEEFEGTYYENNSEKFEDKKVLDEIKEKIKDKNAEIIEKQTERKKEYPPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKFITYPRTGSMALEESLVDRTRNVLEKLKVGLPYEEQIKFVQNKRVFDNSKVESHSAIVPTYMKPNNLTQDERIVYTAVKNRFLMQFMPVAEFEETKITSKINDKEVKGVFISKGKVQLIEGWRVVEKIDSKDTILPMVNEKEIVDLVDSKINKVTKKPPKKHTEKTLLRVMETCGKSFKEDAEEDSEEMMASILSGFSIGTPATRAETIKKLKDVGYITTKGKSLTCTELGRTIVEIFPVKELLDLEYTGRLEKTLSDIERGKVKKEDFLNLIKNFTIEGVKAIKNDDSMAKHFKVEAPEGVEVLGKCPNCGNPVIEGERGFGCVNWKNGCKYTIWKNDKYIASFGKQVTPQMVKLLLANGKVGFRNLKSKKGNTFAAYFIYEKDEEKGYFTWKMEFI
(1152) DNA topoisomerase [Clostridium perfringens str. 13]	3	MKKLVIAEKPSLAMNIVKALNSSESFERKDGYFESENYIISFAFGHLFKLYNIEEYTGEDKGAKWRNDILPFIPKEFKFSIKDDVGVKKQYKILEELIKSNRVDEIVACGDADREGEVIIRLIINNVFNNNSINKKVTRLWLPEQTTQSILYGLNNLKDIDTYNNLANEGFTRTFLDWLVGVNLTRYVTVKSKHLFPVGRVLVPIVQAIYERDKSIENFVPETYYQIESNEKTNDEIIKLVVKELAFTKSEFIKAKSFADELNTYEAIVISKDTKKVKKQPSKLFSLSKLQSLLSKKYKMTFKESLELIQKLYEKGFVTYPRTNTEYLAEAEKGKVKEIIDILCSEGYNLEFKDKKTIFDDSKIESHSAITPTVKIPKEDELKGKMLDVYNTIKNRFISNFLIEETLIDRTIIRIEVGDLEFSLKGDVIVQKGFLEYEPIKKDENTLPNLNVGDKINTNFKAIEKVTQAPGKMTTEMLSNYLKNPFKNYEIENEEEDYKAILDGLEIGTEATRTGIIENAKKYKYISENKSVLSIEPLGRKLIETLDKLNVNLSKEKTVEFSRILKKVYKNELNIDRAVDLISNELKSILEDSKNIEIEAIKEEKEVIGKCPRCGKNIYETSKSFSCEGYKDEPKCQFNIWKEDKFFKDKGKKVTKSIAKNLLAGKKVKMTGLKKKDGNGTYDAFVSLNDTGKYVNYKLDFSK
(735) DNA topoisomerase [Clostridium saccharolyticum WM1]	7	MKLVLAEKPSVAMSLSKVIGANQRGDGYMEGNGYIVSWCVGHLVELSQPEAYDEKYAKWRYDDLPILPEHWQYQVSTSTKKQFGILKKLMLRKDVKSLICATDAGREGELIFRLVYHQCGCKKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCRERADWIVGINATRLFSCLYGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKFRDFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTSLQREANRQLGFTAQQTLDYTQALYEKKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSFQIQPDVPAPVNAAQVINSKKVTDHHAIIPTKTAAGHDISSLPSGEQAILIMLAVRLICAVGTPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGRSSEDAEKNAEACNLPELSEGMTLELAGVDLKEGKTSPPKRFTEDLLLSAMESASSDEFPAGVERKGIGTPATRAAIIEKLVQKGFIERRGDKKTKYLCSTDKGNALVTVVPEQIQSPSMTADWEEKLLKIEHGEYDSDAFMGEISSMVNGLVKTYEAVKGADVLMQPERKVIGSCPACGSDVCETVKGWFCRDKSCKFALWKENRFFQTLGKQMTEELAKQLVNQGKARLTHCYSRKSNRYYDTTVRVETGEDGAAAFKLEFGGKK
(89) DNA topoisomerase 1 [Clostridium saccharolyticum WM1]	1	MANCLVIVESPAKVKTIKKFLGANYEVDASNGHVRDLPKSQMGIDVENDFDPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLMKALKLDELKDKQVYRISFNEITKNAVKASLKTPRVIDMDLVDAQQARRVLDRMVGYMISPLLWAKVKRGLSAGRVQSVALRLICDREEEIGAFIPEEYWNLEAVLKQEGSKKPLIAKFYGDKDGKIPIRNKEELEKILAGLEKQTYQVEEIKNGERIKKAPIPFTTSTLQQEASKVLNFSTQKTMRLAQQLYEGVEVAGRGTVGLITYLRTDSTRIAEEADAAAREYIGKQYGGQYVANGEQQKKSNAKIQDAHEAIRPTDISLTPVMVKESLQRDLFRLYQLIWKRFTASRMQPAVYETTSVRVGAGKYLFTLSASRLSFDGFMSVYVQEDDKEEANVLLGNLEKGSFLKLDKLESGQHFTQPPAHFTEASLVKAMEEQGIGRPSTYAPTITTIIARRYVAKENKNLYVTELGEVVNRMMKKSFPSIVDITFTANLEYLLDKVGDGSVQWKTVVKNFYPDLKEAVDKALVELETVTIADEVTDEICEVCGRNMVIKYGPHGKFLACPGFPECKNTKPYLEKIGVPCPKCGKEVVIKKTKKGRIYYGCEANPECDFMSWQKPSTKTCPKCGAYMVEKGSKLLCSNEQCGYSTDK
(410) DNA topoisomerase 3 [Clostridium saccharolyticum WM1]	2	MKSLIIAEKPSVARDIARVLHCTKNHDGVIEGEAYVVTWGLGHLVTLADPEDYDPKYKEWKMEDLPMMPDQFRLEVIKQTGKQYRVVKAQIHRSDVGEIIIATDAGREGELVARLILEKAGNKKPIKRLWISSVTDKAIKEGFAKIKNGHEYDNLYDAAMCRAEADWLVGINATRALTCKYNASLSCGRVQTPTLAIIARREEEIKNFVPKPYYGISAKCADPALSFTWRDEKSKSFRSFDRDRVEALFNHRKAIGEGVITEVKSVPKKTEPPQLYDLTELQREANRRFNYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDIVPSIKERLEACGVGPYRKLAGRLANQKIKTAPSFVNDKKVTDHHAIIPTEQFVQLDHMTIEERKIYDLVVRRFLAVLYPPFEYEQTEITLDLGGETLAARGKTVKAQGWKEVYENQDEEEEEQELKEQNLPVMKKGDMINGLTVTMTEGKTKPPAPFQESTLLSAMENPVSYMETKDKDMAKTLGETGGLGTVATRADIIEKLFSGFLLEKRGKDIFLTSKARQLLTLVPEDLKKPELTAEWEMKLSEIAGGKLKRAAFMKDIRQYSGELIRQIKTGEGSFHHDNLTSHKCPVCGKRMLAVKGKNNEMLVCQDRECGHREVVSRTSNARCPVCHKKLELKGKGDSQIFVCKCGYKEKLSSFKERRAKEGAGVSKRDVAKYMSEQKKEGNQPMNSAFADAFAKLNLGDNGK
(1620) DNA topoisomerase [Clostridium saccharolyticum WM1]	7	MSKSLYIAEKPSVAQEFANALKANGRRRDGYMESDQVIITWCVGHLVTMSYPESYDPKYKRWSLSTLPFLPREFKYEVIPGVEKQFKIVSSLLNRPDVDTIYVCTDSGREGEYIYRLVAQMAGVKDKKQKRVWIDSQTEDEILRGIREAKDESDYDNLSASAYLRAKEDYLMGINFSRLLTLRYGQHISNYLKSGKNTVISVGRVMTCVMGMVVRREREIREFVKTPFYRVIGTFSKEDPSNPGLSGLDFDGEWRSAPGSRYYESPFLYKENGFKERQYAEELINALSLMDPMEGTVVSIEKKKETKNPPLLYNLAELQNDCSRMFKISPDETLKLVQELYEKKLVTYPRTDARVLSTAVAKEIYKNIGGLKSFTPLSEAAAEVMEKGSYRTIEKTRYVNDKQITDHYAIIPTGQGLASIKGLSSLGIRVYEVIARRFLSIFYPPAVYQKYALELAAESVYPGSEPTLQHQMTNKEHFYANFRVMLDAGYLKVAEVSWGKKKQEEGNGGTPSEETVQEENNPESSQNQMNNPLFVAMLGSLKKGMKLSLKKLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLFHIKYLSLNSKTQVIVPTLLGEMIFDVVNASIRQLLNPELTASWEKGLNYVAEGTITPGEYMEKLENFVAGRTAGVLRLNNHYDLHGVFDAAAANYKKPK
(1276) DNA topoisomerase 1 [Clostridium botulinum A str. ATCC 19397]	1	MGQKMGQNLVIVESPAKAKTIKKYLGKNYVVEASMGHVRDLPKSQLGVDIENNYDPKYITIRGKGELLDKLRKEAKKSSKVYLATDPDREGEAISWHLAHVLKIDESEECRIEFNEITKTSIKKAIKSPRRINENVVDAQQARRVLDRLVGYKISPILWSKIKWGLSAGRVQSVALRMICDREREIEEFIPKEYWTIECEVYKEKNKKPFIIKLTTKSGKKIEINNEEEAIEAIQDLKKGEFIVKKIKKTKKNKNPLAPFTTSTLQQDSYKKLNFSTKKTMSIAQQLYEGIDIKGFGAVGLITYMRTDSIRISEEAQKSTLEHIKSNFGEEYIPKTPRVFKGKKNIQDAHEAIRPTNIEITPTLAKESLTPQQYKLYELIWKRFVASQMASCILDSTSISIENGKYGLRASGSLIAFDGFMKVYEYSTEEEKDSIKIPELEDNEILGEKSINKSQHFTQPPARYSEASLVKTLEENGIGRPSTYAPIISTILDRKYVEREKKTLKPTELGDIVNNILSEYFKQIVDLEFTADMENKLDYIEEGKKSWREVVNDFFQPLIESIEIAEKEIAKITIEDKVTDVVCEKCGRNMVIKHGRYGDFLACPGYPDCKNTKPIVEEIDVKCPKCRDGKVLIKKSRKGRKFYGCSNYPDCDFVSWSEPVKEKCEECGSYMVKKQSKAKGEYYECANSECKHRKYLNNKE
(236) DNA topoisomerase [Clostridium botulinum A str. ATCC 19397]	3	MSKLLLAEKPSVARNIGEALGCKTRKNGYLEGNGYIVTWAFGHLLTLYDCKDYDHKLALWSFQNFPYIPTEFKYKVKNDGKNRNVVDAGAKKQLEIIKELINRGDVEEIISATDYDREGELIALLIFNYLKANKPIYRILINEWTPTEIKKGLKDLKKNEEMISLQDAGVSRQLADWVIGINFTSIATMKYTRGKGNLLNIGRVLMPTLKIIYDREIEIKNFKVEEFYELEATFKNKKGEYKGKFFYEKKEKFPNKKIMEKLKAEIKDKSGLVTEKTIEIKKENPPSLFNLSNLQGYITSKYKGFTADKVLKVAQSLYEKKHITYPRTESTALEESIKDKAKKVLEVLKNDLPFKDEIIFNTSKKVFNNAKVESHSAIMPTYIIPKNLTPDERLVYDAIKNRFISQFMKEAQYENTEIVTTVPGENYERLFKTKGKILKCKGWLKLYKEKKKDELLPPIEKDDEVEIKSLKIISKKTKPPAHHTEKTLLKAMETCGKNTKQSEDNEEESNILYGYSIGTAATRAETINKLKYAGYITPKGKSLLITDKGTKLIETFPIRELLDTDYTGKLEKKLYDMEKGKFKKEDFLKEIFNFTVNGVNKIKNIRSNVICDTRVKKDK
(195) DNA topoisomerase 3 [Clostridium botulinum A str. ATCC 19397]	2	MGKVLVLAEKPSVGRDLAKVLKCNKKGNGYLEGNKYIVTWALGHLITLSDPESYDEKYKKWSMDTLPMLPKRMKTTVIKKTSKHFSEVRKVMIRKDVEELVIATDAGREGELVARWIIDKVGFKKPIKRLWISSQTDKAILDGFRNLKPGKNYENLYHSAVCRSEADWIVGLNVTRALTCRYNAQLSAGRVQTPTLAMIVQREEEIKNFKPRDYYSIEGKTKGFTMHWESAKGRFNTFDEDLAKKVVSKVTGKEGKIIEVTESDKKKYAPALYDLTELQRDANRIFGYSAKQTLSIMQRLYENHKILTYPRTDSRYISKDVVGTLKDRLKAISISNYSKFTNEILKGNIKAHKGFVDDSKVSDHHAIIPTEEKPKLGNLSGEERNIYDLVIKRFLSVMLPPFEYIQTTIKSEVIGEKFVARGKVIKSKGWKAVYDREEFDDKNNNSDSDDIKDQTLPKVNKGDGIKFSNFKINKGQTKPPARFNEGTLLSAMENPQRYINLDKESSKTLGETGGLGTVATRADIIEKLYNTFYIEKRGKEIVPTSKGKQVIDLVPKDLKSPLLTAKWERELDSISKGNLRGQIFINKMRDYSTKLVEDVKNSKDKYVHDNLTGKKCPQCGKYMLEVKGKNGVINVCQDRECGYRENVSRFTNVRCPECHVKLELRGEGQGQIYVCTRCSFREKLSSFNKKYRNNQEKLNKRDVTKYMKKMQKENDEPINSALAEALSKLKL
(748) DNA topoisomerase 3 [Clostridium cellulolyticum H10]	2	MGFTLILAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLIGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFTVQWQDSRNNQTRTFNKEEADGIVAKITGQMGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKPSVTKRFVDNSKVTDHHAIIPTEQFVDLFSLNSEERNIYDLIVKRFIAVLSKPFEYEQTTVKLDIAGESFYAKGKIVKSSGWKTVYDGFGKLDEDDEDDNDQSLPDIQKGHKAKVVGPKSINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERKGKEIYPTSKGTQLISLVPTDLKSPELTAKWEQQLTLISKGKVNSNVFVNDMKKYARKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHICPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGQQVDKREVAKFMRQQEKDENINSALADALAKWKNN
(1178) DNA topoisomerase 1 [Clostridium cellulolyticum H10]	1	MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAIKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVRKGLSAGRVQSVATKMICDREDEIEKFESQEYWSIIAKLVKPKASPNFGAKFYGIGKEKLELTNEEQVNSILEEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGYTTKRTMMVAQQLYEGIEIKGRGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPEKPREYKNKSASQDAHEAIRPTYIDLPHEQIKEYLSPEQYKLYRLIWDRFISSQMSSAIYDTVSADITAGKYLFKANGSKVKFPGFMVLYTEGNDNEGKDEAEQDEKENKLPQLNEGDILELKENTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAEMESELDSVEDGDKEWKAVMRDFYSSFAGVLKKAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNAKPIVEEAGVECPICKGKVLIKKTKKGRKYIGCEKNPECPFMSWDMPSPNKEVCSVCGSFMLQKFSGKKKVLKCSNDKCTSNIEASKDNTK
(1074) DNA topoisomerase [Clostridium kluyveri DSM 555]	3	MKLILAEKPSLALNIVKSIGNMNRNDGYFENRDYLITFAYGHLLRLYDVDNYFKRGKTKWNLDELPFVPEDFKFKIREDKGVKKQYEVIKNLIRRNDVTEIVNCGDADREGEVIVNNIISRIFKEENINKPVKRLWLPEQTTQTIRQELRNLKDNRDYKNLYNEGLARTYLDWTYGINLTRYLSIKSQTFLPVGRVLIPIVKFIYDRDRAIENFKPETYFEIGAVIKKDNLEIKAKLKDRRFSADEREKAANLLNSLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKQFKMSLDDTLKHLQKLYECGFTTYPRTNTEYLAENEKGKIKSIIEVMKEKFNVDIDFKDKKKIFDNNKVESHSAITPTTKIPEIEKLSEDEKKVYTAIRNRFISNFLNEETIIEETYVIIRIVDEVIELKGNVIKQTGFLKYENIKKENELPDFVEDEKLDTKLSVDEKQTQKPNRVTESELNNFLKNPFKKKEIQDLENTNDDEEYKMILEGCEIGTVATRAVIIKNAQKYEYIKEVKGHFECENKGIRLIDVLKRLNIDLDKGKTVEFGKQLKGVYKNDIEINTIIYNVKSELNNIIRKGDEIKIDRIESKKYESMGVCPICGKGNIMANKFGYGCSRWREGCKFFIGKQIAGKNISESMAKKLIKNKKTNVIKGFKSKNGKSFDAVLTIKDENVAFDFSSESKGLGTCPVCGKGNVIANKSGYGCDKWKEGCKFFIGSKIASKSITESMVKKLLKDKKTNLIKGFKSKNGEVFDAFLIIKDSKIVFDFKE
(878) DNA topoisomerase 3 [Clostridium kluyveri DSM 555]	2	MSKILVLAEKPSVGRDLAKVLHCNKKNLGYIEGDKYVVTWALGHLVTLADPEDYDERYKSWVLEDLPMLPDKLKLVVIKQSGKQFNIVKSQMNRKDIGEIIIATDSGREGELVARWIIEKARVKKTVKRLWISSQTDKAIKEGFANLKNSSKYDNLYKAARCRAEADWVVGLNITRALTCKYNAQLTAGRVQSATLAMIVNREEEIKNFKAKDYFVINAKTKEFTLMWRDKNNNSNIYEENRVNKILAITKGKAANIIDVRESYKKQYAPALYDLTELQRDANRIFGYSAKHTLSIMQRLYENYKILTYPRTDSRYISTDIVDTLKERLKAISVGSYKIYASELLKTRINAHKGFVDNSKVSDHHAIIPTEEVLTLSLLSSEEKNIYDLVVKRFLAVMLPPFEYVQTSIITDINGENFIARGKVVKSKGWKKVYDIGNQVIEDDENENQILPELKKGDSIDIISIESRRLKTKPPARFNEGTLLSAMEKPQKYISIDKLYAKTLGETGGIGTVATRADIIEKLFNMFYVEKNGKDIIPTSKGKQLIELVPEDLKSPLLTAQWEMDLELISKGKKDPEVFIRKMREYAGTLVEDVKESSNKFKHDNITGKKCPVCGKYMLEVKGKQGRMLVCQDRECGHRENLARLTNARCPECHKKLELKGEGEKRIYVCSHCSFREKFSSFNKRFKENEGKLNKKEVSKYMKKMNGENKANINSSLAEALANIKFK
(209) DNA topoisomerase 1 [Clostridium thermocellum ATCC 27405]	1	MADKLIIVESPAKAHTIGKFLGKDYKIVASVGHVRDLPKSQMGVDIENDFTPKYITIRGKGEIISKLKKEAKNASTIYLATDPDREGEAISWHLATLLNIDKNEKCRITFNEITKNAVKNAIKSPREINMDLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTITAKLLKGGVKAPFEAKFYGLDNKKTELKSEEEVNKVLDEIKDAVFVVQKVKKGEKKKNPNAPFTTSTMQQEASRKLGFSTKKTMMVAQQLYEGIEVKGVGAVGLVTYIRTDSTRISEEAQNQAAKYIKEKFGESYLPKEKNVYKNKSASQDAHECIRPTSVEMDPESVKDSLTKEQYRLYKLIWDRFVASQMAPAVYDTINADIEAGKYLFKASGSTVKFPGFTVLYQEDKDDETEEGEVIVPELAEGESLKLKKLEPRQHFTQPPPRYTEASLVKALEEKGIGRPSTYAPIITTILARGYVVKEGKTLVPTELGKIVTDIMKNYFQDIVDVEFTAQMEKTLDEVEEGEKRWVDVMRSFYSQFVDVLKNAEEKIGNIEVPEEVTDEICEKCGRNMVIKVGKKGRFLACPGFPECRNAKPILEDAGVTCPKCGGKVYIKKTRKGRKYLGCENNNSDPKCDFMTWDMPSKENCPKCGSFLLKKYSGRKVQLKCSNENCDYVKTGKEKKEDE
(1294) DNA topoisomerase 3 [Clostridium beijerinckii NCIMB 8052]	2	MSKTLVLAEKPSVGRDLAKVLKCNQNKGSYIEGSKYIVTWAMGHLVGLMDPEGYDNKYKEWKMETLPMLPKHMKLTVLKKTGRQYNEVKKQLLRNDVSDIVIATDAGREGELVARWILEKSGVKKPLKRLWISSQTEKAILDGFRNLKPGAAYENLYKAAVCRAEADWLVGLNVTRALTCKYNAQLSAGRVQSPTLSMIVLREDEIRNFKPKTYYTLEGKTRGFNLAWVNKDNNSRIFDEEFANKVASKLKNSEGKIVNINEANKKKFSPALYDLTELQRDANKIWGYSAKQTLNIMQRLYENYKILTYPRTDSRYITTDIVATIPDRLKAISIGEYRIVAEELLKGKIIGNKSFVDNSKVSDHHAIIPTEQKPNLALLSSEERKIYDLVVKRFLSVMLPPFEYIQTTIEAEVQGEKLVAKGKVIKAKGWKKLYDRLEEDSDEEEIKEQVLPTVSIGNSIRVESVNIKKGETKPPARFTEATLLSAMESPHKYINVSKEAAKTLGETGGLGTVATRADIIEKLFNSFVIEKKGKEIIPTSKGKQLMELVPKDLKSPLLTAKWESQLDEISKGKRDDHSFIKEMKNYSVALVEDVKGTNNKFVHDNKTGKKCPNCGKYLLEVKGKNGVMNVCQDRECGYRESVARVTNARCPECKKKLELRGNGEGAIYVCPGSNCNFREKASQFKKRFEKNGKIDKREVNNYMKKMKKEAEEFDDNPFAALLGDIKFDK
(975) DNA topoisomerase 1 [Clostridium beijerinckii NCIMB 8052]	1	MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIENNYTPKYITIRGKGELIDKLRKAAKKAEKVYLATDPDREGEAISWHLANILKISEDETCRIVFNEVTKTAVKASIKQARKIDLDLVDAQQARRILDRLVGYEISPILWKNVKWGLSAGRVQSAALKLICDREKEINEFIPKEYWSIDCTLKKEKKKFPVRLSTYKGKKIEIGNEETSNGIIKELNKGNFVVKSIKKGKKNRNPLPPFTTSTLQQDANRKLNFMTKRTMSIAQVLYEGVEVKNYGTVGLITYMRTDSVRISEEAQESAKEFIEGSYGKEYLPGAPRVYKGKKNIQDAHEAIRPTYVEITPEIAKENLTPEQYKLYSLIWNRFVASQMASCELNTHSIDIENGDYKFKASGSVISFDGFMKIYEYSNEEDENSVMLPELKENEELKVESLNGTQHFTQPQPRYTEASFVKLLEEKGIGRPSTYVPTISTLLGRNYVIREKKNLIPTELGEIVNNIVSEYFRQIVDVDFTADMERKLDDVEEGSENWTQIVEEFFSPLKVAIEKAEKEISKVVIEDKVSDVKCEKCGRMMVIKRGRFGEFLACPGYPECKNAKPIVEELDVPCPECGKPIVAKKSKKGKKFFGCLGYPECKFVSWYEPVKEKCPNCNSYMVAKYSKTKGNYIQCSNSECNYKEEVKKDNSKEE
(1168) DNA topoisomerase [Clostridium beijerinckii NCIMB 8052]	3	MAKVIIAEKPSVAKNIADAFNVKTRRDGYFEGNGYYITWAFGHLLQLYDAKDYDENMKGWRFEKFPFIPEHFLYKVKCDSVDRTVEDKGAKKQLGIIKSLIDKEDVDGIVSATDFDREGQVIADELFGYFKVKKPIYRLLLNEWTPDEVKSGMESLKDNKEMQPLQDAGIGRQWSDWIIGINLTSVSTLKYKFEENKTINIGRVLLPTLKIIYDRDKEIENFTATTYYKLVSNFKTSANEEFEGLYYENDSEKFEKKEDLDKFISRLEGATAKIIDKQTELKKEYPPYLFNLSNLQGHITSKYKGWTSDKVLKVAQSLYEKKLTTYPRTASVVLEESLKDRAKKVLNTLKAGLPYEKDIKFSTSKRIFDSSKVESHSAITPTYIKPSGLSSDEKIVYDAIKNRFIMQFMPIAEFEETKVTLKANVSEMNGIFVSKGKVKLVEGWKVVEKIESKDVILPKIEIDETVDIVDSKVNSVTKKPPKYHTEKTLLRVMETCGKGIEGKDEDSEEMMQAILSGFSIGTPATRAETIKKLKDIGYLKTKGKNLMCTELGRNLVETFPVKELFDLEYTGRLEKTLSDIEKGKFAKSEFIKLITDFTIQSVELIKKDDAALSRFKVEIPKDSENIGPCPVCGNPVIEGEKSFGCSNWKNGCKYTIWKDDRYIASFGKKISKEMVELLLKNGKVGFRNLKSKKGNTFSAYFKYEKNEESGYFNWKIEFIDNK
(861) DNA topoisomerase 1 [Clostridium cellulovorans 743B]	1	MGTNLVIVESPAKAKTIRKYLGKNYVVEASMGHVRDLPKSQTGVDVENNYEPKYITIRGKGELLDKLRKQAKKSEKIYLATDPDREGEAISWHLSKVLKLSETEKCRIEFNEITKTAIKAAIKSPREINMNLVDAQQARRVLDRLVGYGISPILWRKVKWGLSAGRVQSATLRMICERDKKIKEFIPKEYWTIEGIFNSTDDTKNSKEKLNLKLHNFKNEKIEIDTKEKADEILNIIKSGNYTVSKVKKTERIKNPLPPFITSTLQQDAYRKLNFTTKRTMSIAQQLYEGIEIKGKGSVALITYMRTDSVRISDEAQKSALEFINTSYGTEYVPSEPRIYKGKKNIQDAHEAIRPTYIDITPDKIKGDVKDEIYKLYKLIWERFVASQMKSCVLDTVSVTVDNSGYNFKANGSTVKFDGFMKIYSYGTEGDESLTTIPKVQEGEMLSCIQIDGLQHFTEPPARFSEASLVKTLEENGIGRPSTYAPTIATLLSRKYIEREKKTLVPTELGIIVDNIMCEFFNQIVDEEFTANMEERLDDIELGDSDWRKIVNEFFTPVKAEIEKAEIELAKITIEDEVTDIQCEKCGRNMVIKHGKFGDFLACPGYPECENTKPIVEEIDTPCPKCGSKIVVKKSKKGRKFFGCSTYPNCDYVSWYEPSSKKCNQCGSIMLKKYNKTNGNYLECSNSDCKSKEIIQEETE
(274) DNA topoisomerase type IA central domain protein [Clostridium cellulovorans 743B]	3	MSKVIIAEKPSVAKNIAEALKSNIRKDGYLEGNGYYITWAFGHLLQLYDAKDYDEKMAKWKMDNFPFIPKAFKYKVKNDSKKKDKPDAGAKKQLKIIEELINRNDVDMVISACDYDREGQIIGDIITGYLKVKKPVYRLLQNEWTADEVIKGMEKIKPNTEMKSLRDAGISRQWADWTIGINLTSVATLKYQRGKGNPLNIGRVLLPTLKIIYDRDKEIANFVPDNYFKLNATFKTSDNIEYEGAYIEKEQEKEQEKFKEREKLDEISKKMKGCTGVIVDKQTEKKKEYPPYLFNLSNLQGYITSKYKGWTSDKVLKVAQGLYEKKYITYPRTASVVLEESLADRAAKVLNTLKKSLPFQEEVKFIKNKRIFDNSKVESHSAIIPTYLEPKTLSGDEEKVYSAIKNRFIAQFMPIAESEETKIFTRIKNFDLDGIFISKGKVQIVEGWKKVEKIESKDTILPFVNINDEVDTIKTKVSAHSTKPPKRHTEKTLLRVMETCGKKFDEEQSDQMMDAILSGFSIGTPATRAETIKKLKDIGYIYTEGKNLICSELGVKLVETFPIQELFDLEYTGRLEKTLADMEKGKVEKEDFLKLIFDFTTNAINQIKGDKENVINQYEGELVKGESLGKCPCCGNDVIEGKIGFGCSNWRSGCKYVVWKEDKFLMSMGKKITKDMVMSLLADGKVAIKGLKSRKGNIFDASLSYEKNKDNDYFSWKMEFLNSQESKNRT
(756) DNA topoisomerase 3 [Clostridium cellulovorans 743B]	2	MSKTVVLAEKPSVGREIARVLKCTKSGNGYIEGPKYIVTWALGHLVTLADPEVYDDKYKSWRLEDLPMLPKPLKLVTIKQSGKQFNAVKEQLNRKDVDEIVIATDAGREGELVARWIIEKARVKKPMKRLWISSQTDKAILDGFRNLKPSAQYENLYRAAQCRAEADWVVGLNVTRALTCKYNAQLTAGRVQSATLAMIVSREEEIRTFVPKDYFVINAKAKGFNLQYRDKNNNSNIFEVDKVNKVLSAVRGKEANIVEVTESYKKQYSPALYDLTELQRDANRIYGYSAKQTLSIMQRLYENYKVLTYPRTDSRYLSTDIVATLPDRLRAIAVGSYSAVANEILKGKITGHKGFVDNSKVSDHHAIIPTEEKGKLALLSSEERHIYDLVVKRFLAVMLPPYEYLQTTIKADINGETFVAKGNVIKAKGWKKVYDKEATLAEDEDDKDSQTLPVVKKGDKLNVMSIDSEKHKTKPPARFNEGTLLSAMEKPQKYVSLDKVHAKTLGETGGIGTVATRADIIEKLFNMFYIEKNGKDIIPTSKGKQVIDLVPSELKSPLLTAEWELELERISKGQKDSRGFIEAMRKYAAELVDDVKGSSDKFKHDNLTGKKCPDCGKYMLEVKGKQGRMLVCQDRECGHRENLARITNARCPECKKKLELRGQGEGKIYVCPGSNCNFREKASQFEKRFDSKSDKLNKREVAKIMNKLNQEKEDPMDSPFADLMNMFKDKK
(979) DNA topoisomerase 1 [Clostridium cf. saccharolyticum K10]	1	MAKNLVIVESPAKVKTIKKFLGSNYEVDASNGHVRDMPKSQMGIDIEHGYEPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLSKALKLEDCKDKKVYRITFNEITKNAVKAALKTPRAIDMNLVDAQQARRVLDRMIGYRISPLLWAKVKRGLSAGRVQSVALRMICDREEEISSFIPEEYWNLEAKLKAKGSKKKLTAKFYGTREGRMAIHKKEELEAVTAALEGAQYTVDEVKTGERVKKAPIPFTTSTLQQEASKTLNFSTQKTMRLAQQLYEGVDIEGKGTIGLITYLRTDSTRVAEEADKTAREFIEEKYGKQYVSTEEAVKKGGAKIQDAHEAIRPTDISLTPAVVKESLARDLFRLYQLIWKRFAASRMQAAVYETTSVRVAAGYAGGEYLFTLSASKLKFDGFMSVYVQEDEKEESTVLSEKLEKGDVLACEALESSQHFTQPPAHYTEASLVKALEEQGIGRPSTYAPTITTILARRYVVKENKNLYVTELGEVVNRMMKKAFPSIVDTAFTANMEYLLDRIGDGTVQWKTVIENFYPDLEEAVKEAEKKLEAVKIADEVSDVPCDLCGRMMVIKYGPHGKFLACPGFPECRNTKPYLEKIGVACPKCGKEIVIRKTKKGRKYYGCENNPECDFMSWQKPSAERCPECGGLMVEKGNKLLCTNKECGYVKTKENRQQQE
(633) DNA topoisomerase [Clostridium cf. saccharolyticum K10]	7	MKLVIAEKPSVGAAIAAVLGANEKRSGYFEGSGYLVSWCIGHLISLADAATYNEQYRKWKYDDLPIVPQDWQFTVASGKEQQFSVLKDLMHRSDVSEIVNACDSGREGELIFRFVYEQANCKKPFSRLWISSMEESAIREGFSNLKDGRSYDDLYQSALCRAKADWLVGINATRLFSILYHKTLNVGRVQTPTLTMLVNRDYAISSFKKEKYHVVRLNAGGVSALSERLNDEAAAQQMKAACEKSQAVCTSLKKEKKTVSPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYPRTDSKYITSDMQDSTKELITGLCSLLPFMRDVKLQADLTRVCDNSKVTDHHAILPTAEFLKAGFSSLADSETKLMTLVCAKLLCAAAAPYEYEAVTAAISCGGYTFTAKGKTTLCEGWCEIEKLSRAASEEQDEDAEPETVLPPLAEGQTFDNPAAEISERYTQPPKAYTEDTLLSAMENAGKEETPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLAAILPEVLTSPQLTAEWETRLTGIAKGSDSPDDFMRSIEEMTAGLVKTYSAISEDKAKLFTPQREAIGTCPRCGAAVYEGKKNYYCSDRACSFVMWKNDLFFQQRKKTFTKAIAAALLKDRKVKIKGMYSTKTGKTFDGVVLLADTGGKYVNFRVEQNRK
(1740) DNA topoisomerase III, bacteria and conjugative plasmid [Clostridium cf. saccharolyticum K10]	7	MRLVIAEKPSVAKSLATVLGAATRKDGYLEGNGWLVSWCLGHLAGLADAATYNPDYAKWRYDDLPILPETWRFTIAKDKRDQFDVLRTLLRREDVTEVVNACDAGREGELIFRTVYCLAGCQKPMKRLWISSMEDSAIREGFAHLRPGADYDGLHQAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDAFKPVPFYTVALDLPGFTAASARMDKKADAEQLKNACQSGTVTVKQVARRDKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQNLYEKKLCTYPRTDSRYLTSDMAEGLPVLVNLVANAMPFRKGIAISCDAAAVINDKKVTDHHAVIPTRNIREADLSALPVGERAILELVALRLLCAVAHPYIYDETSVTVECAGAEFTAKGRTVKQPGWRALDAAYRASMKNAEPDKETEDKALPELAEGQELPVAGAAVKEGKTTPPKHFTEDTLLSAMETAGAKDMPEDAERKGLGTPATRAGILEKLVSTGFLERKKSKKTVQLLPSHDAISLITVLPEQLQSPLLTAEWEYRLGEIERGELAPEDFMAEITAMLKELVGTYQVIKGSEYLFAPPREVVGKCPRCGGEIAEMQKGFFCQDKSCKFAIWKNSKWWAAKRKQPTKAIVAALLKDGRARVTGLYSEKSGKTYDATVVLEDTGQYVNFKLEFDRQKGGGK
(871) DNA topoisomerase [Clostridium cf. saccharolyticum K10]	3	MAKALYIAEKPSVAQEFANALKISGRRADGYIESETAVVTWCVGHLVTMSYPEEYDIKYKRWSLETLPFLPAEFKYQVIDGVKKQFQTVSTLLNRSDIDTIYVCTDSGREGEYIYRLVAQMAGVHGKKEKRVWIDSQTEEEILRGIREAKELKEYDNLAASAYLRAKEDYLMGINFSRALTLKYGPSISSFLRSKWTVVSVGRVMTCVLGMVVRREREIRNFVKTPFYRVIGTFTRESMKISAEWRAVQGSRYFQSPFLYRENGFKEREKAEELIAWLSAEGPVTGTVFSVEKKKETKNPPLLYNLAELQNDCSKMFKISPDQTLKIVQELYERKLVTYPRTDARVLSTAVAKEIGKNLSGLKGFSPCASFAAEVLQGTAWKTIAKTRYVNDKQITDHYAIIPTGQTGAVRNLPSLNAKVYELIVRRFLSIFYPPAVYRKYSLEIAAKTEHFFANFKILKEPGYLKVADVSGIRKKDENAEGTKDTAGAAGESSGEQSAGDSRQEETVIGDEAFAAMLEKLKKGMTLDLSGLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLMSISYLSLNPKTQVITPTLLGELIYEVVNASIRQLLNPELTASWEKGLTYVAEGSITEKEYMEKLERFVAGRTYGAVHTANQAGLRRQFELAAASYKGAEKLPGKGAASAEKAGKNVKNSRKKSAKTGGTINEKN
(268) DNA topoisomerase 3 [Clostridium cf. saccharolyticum K10]	2	MKSLVIAEKPSVGKDIARVLGCRKSADGCLEGDKYIVTWAFGHLVELAAPEEYDKKYKDWNMADLPMMPEPFKLEVIGKTAKQFGVVKRQLFRNDVKDIVIATDAGREGELVARFILMKAGCRKPLKRLWISSVTDRAIKEGFSRLRDGREYNHLRDAAMCRAEADWLVGLNATRALTCKYNAQLSCGRVQTPTLAIIAKREEEIRNFRPKAYWGLTARTSKPALTLTWQDKKSGGMRSFDRDRMEGLQKSLRDQQVRITKVKKTPKKTMAPLLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDVADTIHDRLAACGTGPYRKLAGKLSKNVWTKKASFINDGKVTDHHAIIPTEQFVQLQNMTSEERKIYDLVVRRFLAVLYPAAEYDETVITAEIGGEIFTARGKVMRTPGWREVYESADESGLSGTGGYLDEEDGDEDGEGPQNEERVKAQTLPDLREGDVTGPAGISLTEGKTKPPAPFNEAALLSAMENPVRYMESGDRAMAKTLGETGGLGTVATRADIIEKLFSGFMLEKKGKDICLTSKAKQLLRLVPEDLRKPELTAQWEMRLSKIAEGEMKRDAFMEDIRTYTKDIVEEIKGGEGTFRHDNLTNTKCPRCGKRMLSVKGKNSQMLVCQDRECGYRETISRTSNARCPKCHKKMELRGKGENQMFSCVCGYKEKLSNFKERRQREGAGVTKRDVARYLNQQKKEEKMVNNPFADALKKMQEQDV
(326) DNA topoisomerase [Clostridium novyi NT]	3	MEKSLFITEKPSVAMEFVKLLNIKETKKDGFIESDNAIFTWCVGHMVTMSYPEAYDENLKIWSLKTIPFLPKEFKYELIPSVLKQFNVVKSLMLREDVKTIYVCTDSGREGEYIYRLVDMMVGVEGKDKKRVWIDSQTEEEIKRGIKEAKPLSEYDSLSDSAYLRAKEDYLLGINFSRLLTLIYGKTVSNIIGEDRVVIAVGRVMSCVLGMIVERELQIRNFEKTPFYKINGSIEIEENLGYECEFKAIEKSKYFESPKLYNDGGFKEKKDAEKLIEEIRIESKDNTAIIEKISKKKETKNPPLLFNLAELQNECSKNFKISPDETLNIIQELYEKKMLTYPRTDARVLSTAIAKEINKTISKLLRFKENEKVNNACKNILEKKLYVGLEKTKYVDDKKITDHYAIIPTGEGLESYRSLKPFQRNIYDLVVRRFLAIFYPPAIYSKITVETKIGEEYFFTTEKVCVTRGYLDILEEAQKDEKEKNLDFLNKLKKGTIVKIDELTIKEGKTSPPKRYTSGSIIIAMENAGKLIEDDELREQIKGSGIGTSATRAEILKKLERIEYIKVNNKTQIITSTTKGEVIYRVIRSSMPSLLNPKLTASWEKGLSMVVDREITPEVFMNKLENYINKNISNVVDNNRVINTNYLISGLEENNKKKIDEEKIDDVLGVCPICKKGTIVKNNKGYGCNNWKEGCKFFVAEICGVKIPVGEIKNLIKYGKTNIINGFKSKKGNEFRARLILKDNKVQLSFD
(613) DNA topoisomerase 3 [Clostridium novyi NT]	2	MGKILILAEKPSVGRDIARVLNCKKGGNGFLEGDKYIVTWALGHLVTLADPEAYDNKYKSWNIEDLPMIPKHLKLVVIKKSGKQFNTVKAQMNRKDVGEIVIATDAGREGELVARWIIEKAHIKKPIKRLWISSVTDKAIKDGFKNLKDGREYNNLYKSAIARAEADWLVGINATRALTCKYNAQLSCGRVQTPTIAMIAQREEEIKNFKPKTYYGIEAKSDKLKLVWQDSRSNDIKTFNKDKCENIIKNIKNKDAKVVEVNKVKKKKFSPQLYDLTELQRDANKIFNFSAKETLSIMQRLYENHKVLTYPRTDSRYLTEDVVDTIKDRLKACGVGVYGKYANKLLKGTIKGNKSFVDNTKVSDHHAIIPTEQKFALASLSDNERKIYDLVVKRFFAVLYPPFEYEKTTIKAKIGEENFIAKGKVVLANGWKEVYSNDFEDDMEDELKEQILPSINKGDSIKINSISKTTGETKPPKPFNEATLLSAMENPVKYMSGESKELKKTIGETGGIGTVATRADIIEKLFNTFLIEKRGKDIFITSKGKQLLDLVPEELKSPALTAEWEQKLTAISKGKLNKDKFLSEIKDYSKDTVNEIKNSKEKFKHDNMTRVKCPECGKYMLEVNGKKGKILVCQDRECGYRKGISRISNARCPECHKKLELRGEGEGQIFVCKCGYREKLSAFKERKKKDSGKVSKREVNKYLRQQQKENDEPFNNPFAEAFKKLGLK
(122) DNA topoisomerase 1 [Clostridium novyi NT]	1	MGQKLVIVESPAKAKTIGKYLGKNYIVTASMGHVRDLPKSQLGVDIENNYNPKYITIRGKGELLSSLRKQAKKSDKVFLATDPDREGEAISWHLAEALKIDENEECRIEFNEITKNAIKSAIKNPRRLNLNLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMICDRENEIKEFNPKEYWTIECELKNEKSKKSFTVKLVSKNNEKIEINNEEESNSIIKELKQNKYIVKSIKKSEKHKKPLPPFTTSTFQQDSYKKLNFSTKKSMSVAQQLYEGIDIKGKGTIGLITYMRTDSVRISDEAQKNARQFITENFGQNYVPESIRNFKGKKNIQDAHEAIRPTYIELAPDEIKDNLKPDQFKIYNLIWKRFMASQMADCIMDTMSININNGQYTLRVSGSNIKFDGFKKVYKYEEDEESLKFPVLEENEILQDKKVEGKQHFTQPPARFSEATLVKTLEENGIGRPSTYAPIVSTLLDRKYIEREKKTLTPTELGFIVNNIVSEYFKQIVDVEFTAEMESKLDNIEEGKEKWKDVVNEFYSPLIECINIAEKEIAKIKIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVKELDVPCPVCGGKILLRKSRKGRKFYGCSNYPECNFVSWSEPVKDKCPNCGSYMVKKQSKSKGNYIECSNKECKTKIQQENQNVEK
(518) DNA topoisomerase 1 [Clostridium clariflavum DSM 19732]	1	MADKLVIVESPAKAHTISKFLGKDYKIIASVGHVRDLPKSQMGVDIENNFEPKYITIRGKGDVISKLKKEAKNAKKIYLATDPDREGEAISWHLAYLLNIDSKEKCRVTFNEITKNAVKNAMKEPREINLDLVNAQQARRILDRIVGYKISPILWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTIDAVLQKKDEKGSFNAKFYGKDGKKMELKSEDDVKRILENIKGKPFIVQKIKKGEKKKSPAPPFITSTMQQEAARKLGFSTKKTMIVAQQLYEGIDIKGVGALGLVTYIRTDSTRISDEAQQDVIQFIKEKYGEKYLPTEKRVFKNKNASQDAHECIRPSQVNMDPDSIKDSLTKDQYKLYKLIWSRFVSSQMASAEYDTISTDITIGDYTFKANGQMLKFPGFTVLYQESKDEEGEEKENDIPDLIEGEELKQKKIEPKQHFTQPPPRYTEASLVKTLEEKGIGRPSTYAPIITTILARGYVVKDGKTLMPTELGKIVNDIMKTYFQDIVDVEFTAQLEKKLDDIEEGYKKWVDVMQSFYSPFAKVLEEAEEKIGNVEVPDEVTDEICEKCGRNMVIKMSRFGKFLACPGFPECRNARPILEEAGVKCPKCGGKVYIKKSKKGKKYLGCENNPTCSFMSWDMPSKESCPKCGNFLLKKYLGKKVQLKCSNEECDFIKDGERKKEE
(1087) DNA topoisomerase [Clostridium clariflavum DSM 19732]	7	MGKNLYITEKPSVAASFAAVLGVNISKSDRTRGYAESKDSVVTWCFGHLITLALPDAYNDAYKEWKVEHLPIIPEEYKYVVIDDEGIKKQFETVKSLMLREDIDYIYACTDSGREGEYIFRLVYEHSGTTKPAKRVWISSQTEEAIKEGIKNAKDISHYDSLAQAAYSRAKEDWLFGMNFSRIYTCLYGRHLSALLKESRSSVIAIGRVMTCVLGLVTDREKEIRNFVPKTHYGITANFISMDNKIEYKGKWVPEKSKIIKFADDAQDEERYISKQEAEEVIEKLKGKEGKVKKVEIKSKNEQPPLLFNLAELQSEANKKFKLPVDKTLETAQSLYEKKLITYPRTDCRVLSTDVVGELPKVLNGLYMNPEYKGFVSRIKDFGELKITKSTKRYVDDSKVTDHYALIPTYVTADLNRLSENERKIYNLIVKRFLAIFYPPAVYNTVKVETEIDGEVFVTSSRTLKEAGWKEVYEVSKSKDEEDLTEVPIHLLSKNEGCETKNFELEEKETKPPPRYTAGSLIITMEKAGKFIEDEELREQIKTCGIGTSATRAGIIKKLKDIGYINIDSKTQVVTPTLKGEAIVELVRRTAKELLSPSLTASWEKGLAMIENKETTQEIFEKKLCDYINKTIQKVKKSNSDNSINLIRMFKDVI
(1618) DNA topoisomerase 3 [Clostridium acetobutylicum ATCC 824]	2	MGKILVLAEKPSVARDLAKVLKANINKKTHLEGNKYVVIWALGHLVSLADPESYGEKYKKWSMDTLPMLPKNMKLSVLKNTSKHFYDIKKVMERKDLDELVIATDAGREGELVARWIIEMAKWKKPIKRLWISSQTDRAVRDGFAHLRDGRDYENLYKSAKCRSEADWFVGLNVTRALTCKYNAQLSAGRVQTPTLYMIVSREEEIRKFKPKDYYTIEGKVKSFSMNWHDKSGDFKIFNKERAEKIEALVKGSKGKIVDVSESKKKKYSPALYDLTELQRDANRFFGFSAKETLSIMQRLYENHKLLTYPRTDSRYIPHDVVATLPDRLRAISIGKYSKFAAEILRSKINVHKGFVDDSKVTDHYAIIPTEERPALGALSNEEFKIYDLVVKRFLSIMLPPFEYIQTTVKAEVAGEIFIAKGKVVKSKGWKEVYDKTEDFEEKSELKDQMLPEMNKGEDITFSTVSIKKGQTKPPSRFTEATLLSAMENPQRYVSMDKISAKTLGETGGLGTVATRADIIEKLYKTFYIEKKGNEIVPTSKGKQLVNLVPSDLKSPLLTAKWEGQLDAISKGKLNGVSFVNEIKGYASKLVDDVKGSKDTFKYDNLTGTKCPECGKYMLQVNGKKGRMLVCQDRECGHRENLAMFTNVRCPECHKKLELRGEGEGRIYVCPNCSFREKYSSFQKRFKGNNNKVNKREVSNYMKKMKKEAEAPINNAFADLMSMFKDKN
(1526) DNA topoisomerase 1 [Clostridium acetobutylicum ATCC 824]	1	MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIDDNYNPKYITIRGKGELLDKLKKAAKKCDKIYLATDPDREGEAISWHLSKVLKIDESEKCRIEFNEITKNAIKTAIKCPRKININLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMVCSREKLINDFKPEEYWSIDAQVYKQSKKDKFTIRLTSFKGKKIKINNEEENEQIINSIKKDEFKVENVKEGTKNKNTLPPFTTSTLQQDANKKLNFSTKKTMSVAQQLYEGIDVKGHGTIGLITYMRTDSVRVSKEAQEAANDYILNEYGKEYLPPSPKLYKSKKNIQDAHEAIRPTYIELTPGMVKSSLKDDQYKLYNLIWSRFMASQMANCILNTLSIEIKNGEYTFRASGSNVKFEGFMRVYKYNIEEDEHNEKIPLLQKGDLLHTDKIDGKQHFTQPPARFTEASLVKTLEENGIGRPSTYAPIISTLIDRKYVKKEKKAIFPTELGNIVDNILSDYFKQIIDIEFTADMENKLDNVEEGKENWKEIVDEYFKPLKEAIDIAEKEVAKITIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVEKLKVKCPKCGGDVIVRRSKKGRKFFGCSNYPDCDFVSWFEPTEENCPNCGSFMVKKFSKAKGYYLQCSNQECKYEKSNPDPDKK
(1386) DNA topoisomerase [Clostridium acetobutylicum ATCC 824]	7	MRKILVISEKPSVGRDIANVLGCKTRGEGCLIGAKYIVTWAVGHLVTLWEPEEYNAIYKKWRFDTLPIIPEVMKIKPIDGTKKQFNIIKKLMNDNSVESLICATDAGREGELIFRYTYEAAECKKPFSRLWISSMTDEAIKEGFSTIKPGTEYDNLYHSAKCRSEADWLVGMNASRAYTLKYNVLLSVGRVQTPTLAIIVKRQKEIDNFEPKDYWEVVSKYEGFNGTWFDKETKESKIMDKKKADDLGAKILGQTGKVISIENKKKKQVPPLLYDLTELQRDCNKKFGFSAQKTLDIVQSLYEKRKMVTYPRTDSRYLSHDMVNKIKKTIGRLNINPYDKYVGEILKLSKLPMGKRIIDDSKVTDHHAIIPTDVKPNLSTLTKDELKVYDAIVRRFLCVFYPNYEYTITKIVTEVVEENFLTQGKTILKLGWMEFYKHDKKEKDDENSEPDELPKLKKNESVQVKDSEIKAKKTKAPSSYTEASLLSAMENAGRFVEDEQLKEQLKDGGLGTPATRASIIERLIQVGYIQRKGKSLHPTDKGMKLIEIVPYELRSPETTGKWEKGLSSISKGKMASERFMQSIKRYVQYIIQESVKVNRSVVFQNNDSKFPQKNKQLPEAIGECPFCKRGKVYENSKAFYCSEWKGGCKFTTWKDSLKNYGIQVDKDLEKKLLKERVLYNVFGIEPKSGEKTVYTLKMNNYGAVIAKTQ

Family distribution

Taxonomy tree

Clostridium