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Taxon : Actinobacteria
Informations
Name
Actinobacteria
Rank
class
# topoisomerases
136
Lineage and sub-taxa
Lineage
Bacteria
>
Actinobacteria
>
Actinobacteria
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(1565) DNA topoisomerase 1 [Clavibacter michiganensis subsp. sepedonicus]
8
MYGVPCRGPRRTSPRIGSDPSGHASRTPGRSSVPMNAYIRSHVPGTKKLVIVESPAKAKTIAQYLGSGYEVQASVGHIRDLIEPKNLPPELKKGTLGKFSVDVENGFEPYYVVSDQKKKTVADLKRALKDADELFLATDEDREGEAIAWHLLQVLKPKVPVKRMVFHEITKEAIERARDSTRDIDTALVDAQETRRILDRLYGYEVSPVLWRKVGPGLSAGRVQSAATRLVVDRERERLAFVTASYWDLTASLSPLEQELPFDARLVRIDGARIATGRDFDDKGALKNDSRPLDASSAEALAEALRDPSVPLKVQSVESKPYTRRPAAPFTTSTLQQEAARKLRFSARQTMSVAQSLYENGYITYMRTDSPSLSQQAINAARKQAAELYGPETVPDKPRLYAGKSKNAQEAHEAVRPAGETFRTPQQLASTLRGNDHKLYDLIWKRTIASQMADAKGSTASVVIAAGPTSAGEVAEFAASGTVITFRGFLAAYEESRDEERHGAAEPREAKLPDLKKGQDLRLVDVDAKGHETSPPPRYTEASLVKTLEELGIGRPSTYAAIISTIVDRGYVTPRGTALVPNWIAFSVVRLLEEFFTELVQYDFTAGMEDDLDRIAEGAAERVDWLKGFYYGNDAHKGLRPTIDNLGEIDAKEINSLRIADDITLRIGKYGPYLEVHEEGAAADATPRRVNLPEDLAPDELTAAKARELIDAPVVTDRVIGINPDNGKQVVAKDGRYGPYVTELDPEPEPEAAPAAAADGVDPATGEVLESASTTTTAAPAKKAPAKKPAAKKAAAVKPRTASIFKSMDLATVDLETALRLLDLPRVVGEDPETATPITAQNGKYGPYLKKGTDSRSLTSEEQIFEIDLPGALEVFAQPKYGARRPSSALKEFDADPVSGKGIKVKDGRFGPYVTDGETNATIPKSESVEDIDFDRAVELLADKRAKGPAKPKAKAKAPAKAKAKAPAKAKAPAKPGAAAKATGTTAAATKAAATRAANKAAAAAATASDAT
(479) DNA topoisomerase 1 [Mycobacterium avium 104]
8
MADPKLKENTSGGNGSRRRLVIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPEKKHTVSELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPTFAARLTSVDGLRVATGRDFDSQGQLRKADEVIVLDEPQATELAAGLQGAQLSVASVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSGSAINAARTQARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSLRIGGQAGDRQVVFSASGRTITFPGFLKAYVETVDELAGGEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERRTDWLNNFYFGGEHGVADSIARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVGKNGPYLERMVTGDDGEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHEIVAKDGRYGPYVAEVLPEPPPDDDDGSGAPAKKGKKPTGPKPRTASLLRTMDLQTVTLEDALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRGNDSRSLATEEQLFDITLEEALKIYAEPKRRGRQGAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQRAAELLADRRARGPAKRTAKKTSRKAPAKKAAKRG
(1881) DNA topoisomerase 1 [Frankia alni ACN14a]
8
MPATRPSSRAAAGRAATGRRPTSRSATGSGGSTGAAAEPTPGSGTRLVIVESPAKAKTIAGYLGPGWQVESSIGHIRDLPRSAADVPAAHKGKPWARLGVDVDNDFEPLYVVTPDKKLQVSKLKALVKEASELYLATDEDREGEAIAWHLLQTLKPTVPVKRMVFHEITPQAIRRAVDNPREIDENLVNAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRVLVERERARMRFRAAEYWNIEGLFGATVARQAWPAGTDGADADATGGGVERTPLPATLVALDGNRIATGRDFAPTGELTTSGVTRLDEAGARALTDRLAQAAFAVRSVETKPYRRSPYPPFMTSTLQQEAGRKLRFSSQRTMQIAQRLYENGYITYMRTDSTNLSETALAAARSQAESLYGPEYVPASPRTYTKKVKNAQEAHEAIRPAGDHFRTPGEVRGELDVDSYRLYELIWQRTVASQMADARGTSATIRLGATSSTGEDAEFSASGKVITFPGFLRAYVEGADDPDAELEDRERRLPDVRQGDPLAVRSLTPRGHTTSPPARFTEASLVKTLEELGIGRPSTYASIIGTIQDRGYVWKKGSALVPSFVAFAVVGLLEDHFGRLVDYRFTATMEDDLDDIAAGTSASTDWLTRFYFGTGDGTDPATAAGLKHLVSERLGEIDAREVNSIPLGKADDGTTVVVRVGRYGPYVQLGEGRASVPDDLAPDELTVARALELLAAPSGDRVLGVDAATGATITAKAGRFGPYVTTDTDPPRTSSLLRTMSLETLTLDDAVKLLTLPRTLGAGADGEEVTAQNGRYGPYVKKGAESRSLESEDQLFTVTLEEALALLAQPKARGRRQAAQTPPLRELGNDPASGKPMVVREGRFGPYVTDGETNASLRKGDAVESITDARAAELLADRRARGPAPAKRAARGTAKTTATKTTATKTTAAKSSAAKTTTAKSTTAKTGAAKSTTAKTAAKSATTKSATTRGAAAKSATTRSGTKSSTAKKVGEESAATGSSAPDDGGGAAEAASGGTRRTD
(888) DNA topoisomerase 1 [Actinosynnema mirum DSM 43827]
8
MAGSTRTRKSTGGSAGGNRRLVIVESPTKARKIASYLGNGFVVESSKGHIRDLPRGAADVPAKYKGQPWARLGVDVDHDFEPLYIVTPDKKSTVAELKELLKGVDELYLATDGDREGEAIAWHLLETLKPSVPVRRMVFHEITEPAILAAAASPRDLDLSLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERERMKFVTASFWDVSATIDAGAEATPRQFAGRLVSVDGTRLATGRDFGSDGRLKDGVEVKVLDEAHARAIAEGLTGAAMRVASVEEKPYTRKPYPPFMTSTIQQEAGRKLRFSADRTMRAAQKLYENGYITYMRTDSTALSETAITAARAQATDLYGAQYVAKEPRQYTRKVKNAQEAHEAIRPAGEVFRTPGQVARELDSDEYKLYELIWQRTIASQMADARGNTTSVRVAGRTGGGEDVLFASSGRTITFAGFLKAYVETVDSEAGGNADDAESRLPQLVAEQPVSAAELSADGHSTSPPPRFTEPSLIKTMEDLGIGRPSTYASIISTIQDRGYVWKKGSALVPSWVAFAVVGLLEQHFGRLVDYDFTAALEDELDGIAEGRQERTTWLSGFYFGGDVGPESSIGRSGGLKKLVGSSVEEIDAREINSIPLFSDEGGHTVVVRVGRYGPYLEREVDGASQRANLPDDLPPDELSLEIAEKLFATPQEGRSLGNDPATGHEIVAKEGRFGPYVTEVLPEPAEGKKAGKPRTSSLFKSMSLDTVTLEDALRLLSLPRVVGADPESGAEITAQNGRYGPYLKRGTDSRSLTSEDQLFTVTLDEALKIYAEPKKRGRAAAAPPLKELGNDPVSGKPMVVKEGRFGPYVTDGETNASLRKSDNVETLSDERGSELLAEKRAKGPSTKKKPAARTTKAAAKPAAKKPAAKKTPAKSKG
(830) DNA topoisomerase 1 [Stackebrandtia nassauensis DSM 44728]
8
MAQTTKRLVIVESPAKARTIAGYLGDGYMVDSSLGHIRDLPRNAKEVPPKYAKEPWSRLGVDVDNDFAPLYVVNPDRKAHVKTLKDQLAEADELLLATDEDREGEAIAWHLLETLKPKVPVKRMVFHEITKSAITQAVNNPREINRSLVDAQEARRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRIVVERERARMRFVTADYWGITAQLRTKDGADFAANLLSFDGDRVATGKDFDAETGRPKAGVVHLDEAGARGLAARLANVPYTVGKVDNKPYRRRPYPPFMTSTLQQEASRKLRQSSAQTMRLAQRLYENGYITYMRTDSTNLSETALTAARRQAAQLYGERFVPAEPRRYARKVKNAQEAHEAIRPSGDSFRTPSELASELSTEELRVYELIWRRTIASQMTDAVGNSVSVRINVTSATGEDCEFSASGKTITDPGFLKAYVESRDEGEADDAERRLPELERGQALTADSLEPAGHRTQPPARYTEASLVKALEERGIGRPSTYASIMQTIQDRGYVFKRGQALIPAFLAFAVVGLLEKHFARLVDYDFTAGMESELDDIAAGEGRSLEFLRSFYFGGNNAADGTVAASGGLKKLVAEELGRIDARGVNSIPLFTDEQERRVVARVGRYGPYLERFAPTAEPGEPGERVSIPDSLAPDELTQAKAEELYEVGSGERELGEHPETGEIVYAKSGRYGPYVTSGEKSASLLSDMKLKDITLDDAVRLLTLPRLVGVDADGEEVRAGLGPHGPYVVKKRDYRSLETEEQLFTVTLEQAQALLAQPKKRGRQAARPPLKELGTDPATKLTVVIKDGRFGPYATDGETNASLKKTDTIEDITIDRASELLAERRAKAPVAKKAAKKAAKKTTAKKTAKKTVKKAAKKTAKKTTTTKKAAKKSAAKKKTGNPREDA
(1865) DNA topoisomerase 1 [Brachybacterium faecium DSM 4810]
8
MTGGRHLVIVESPAKARTIGRYLGEEYDVKASVGHIRDIPVPRDLPAEMKKGPYGKFGVDVENGFDPYYIVSPDKKKTVAELKKALKDADTLYLATDEDREGEAIAWHLLETLKPKKSLPVKRMVFHEITKDAIRAALENTRDIDASLVDAQETRRILDRLVGFELSPVLWRKIKPSLSAGRVQSVATRLVVERERERMAFVAADYWDITGTFAAEGGADGTQFTAKIATVDGARVATGSDFADDGTLKPRAKNAAVLTAESTQTLVEVLGDAPATVTALESKPYTRRPAAPFTTSSLQQEASRKLRLGARQAMRVAQSLYENGYITYMRTDSVTLSGEAIRASRAQAAELYGSQFVPDKPRYYQNKSQAAQEAHEAIRPAGDHFRTPAEVAGQLSGDEFRLYELIWKRTIASQMADAKGTTSTVELLLENEGRAATFRAAGTVITFRGFLAAYEEGRDASRYKDDEEKGGDKRLPQMEEGQTLDTRALTPDGHTTTPPPRYTEASLVRALEDRGIGRPSTYASTVATVQDRGYVLRRGTALVPSWTAFAVVRLLEEHFGPFIDYDFTAQMEQQLDRMAQGDLARSEYLKNFYLSDGTDGPIGLKPMVDDLGEIDARAINSIEIGEGITLRVGRYGAYVEQFPRDEDGELIEGADPRRANVSDEVAPDELTVEKAKEMLERAKDDGRVLGTDPETGHEIVAKDGRYGPYVTEVLPEAQTADGKKVPKSKQPKPRTGSLLKSMDLSTVTLEDALKLLSLPRVVGTAADGTEITAQNGRYGPYMKKGTDSRSLETEEQIFSITLEEAEKIYAQPKTRGRAAAKPPLKELGTDPTSEKPIVIKDGRFGPYITDGTTNVSLRATEKVEEITEKVAIEKLAEKRAKGPAKKKAPAKRTTTRKKSTTTKK
(278) DNA topoisomerase 1 [Beutenbergia cavernae DSM 12333]
8
MPSSARKLVIVESPTKARTITPFLGDDYDVEASVGHIRDLPQPSELPAEMKKGPYRKFAVDVENGFDPYYVVDADKKKKVSELRKKLKAADELYLATDEDREGEAIAWHLLEVLEPKVPVKRMVFHEITREAIQRALEATRDLDTRLVDAQETRRILDRLYGYEVSPVLWRKIGPGLSAGRVQSVATRLVVERERERMAFRSANYWDVRGEFSGGRGETAGTSFSARLTALDGDRVATGRDFDDSGSLTSRAVHLDEAAATALVSALDGVDVVVRSVDTKPYTRRPAAPFTTSTLQQEASRKLRMNSRATMRTAQSLYENGYITYMRTDSVTLSTQAITAARRQAAELYGAEYVPDAPRLYANKSKNAQEAHEAIRPAGDSFRTPAQVASRLSGDEFRLYELIWKRTVASQMADAKGSTASVKLGASAAYPDGATRDAEFSASGTVITFRGFLAAYEEGRDAGRYDEDGDGAGRGSSSGSSAARETRLPDLAQGDQVAAESLTAEGHDTSPPPRYTEASLTAALEERGIGRPSTFAATISVIVDRGYVLRRGQALVPSWLAFSVVRLLEDHFGRLVDYDFTAAMESDLDRIARGEQDRVAWLTRFYFGDEAAGSEGLQQLVSELGDIDARGINSIDLGGGVTVRVGRYGPYLEATGPDGEPQRASVPDDVAPDELTLERARELLATQGEGDRELGTDPATGRTIVARSGRYGPYVTEVIPDDAPAASDDAKPAKRKPAKPKPRTASLLQSMQLEAVDLEQALKLLSLPRVVGVDPESGDEITAQNGRYGPYLKKGTDSRSLETEDQIFDITLEQALAIYAQPKQRRGQRASSALRELGDDPVSGKPVSVKDGRFGPYVTDGTTNATLRKDDEVESITPERAFELLAEKRAKGPAKKRTTARSSSRKAPAKSRS
(1284) DNA topoisomerase 1 [Jonesia denitrificans DSM 20603]
8
MSQGRKLVIVESPAKARTISAYLGADFDVEASVGHIRDLPQPSELPAEMKKSGYGKFAVDVDNGFAPYYEVYPDKKKKVTELRRLLKDADELYLATDEDREGEAIAWHLLEALKPKVPVKRMVFHEITREAIQRALTTTRDLDERLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVPASYWDVTAQFEATQGQDAGGTFQARLTHVDGTRVATGRDFTDRGELKARDVVHLTEDAATTLAQSLTDAPATVASLDTKPYTRRPAAPFTTSTLQQEASRKLRMSSKTAMRVAQTLYENGYITYMRTDSPALSAQAISAARSQAADLYGTEFVPEKPRHYASKSKGAQEAHEAIRPAGDTFRTPAQVANVLSGDQFRLYELIWKRTVASQMADARGSTASVRIDVPGQVDGQTTTATFSASGTVITFRGFLAAYEEGRDVDRYDDGSQSDGRLPHMVEGDPLASRDVSADGHTTTPPPRFTEASLVKALEERGIGRPSTYASTISTIQDRGYVNNRGQALVPSWLAFSVIRLLEEHFSQLIDYDFTAQMESDLDEIAAGQGDRVNWLTQFYFGGAGGDKAGLKELVEGLGDIDAREINTVSLGEGIVLRVGRYGPYIEHLTADTAEGENPPRASVPDDIAPDELTLDVARDLLENQKDGDIELGSDPVSGHMIVAKSGRFGPYVTEIIPEPELDESMSAAAKKKAKAALPKPRTASLFKSHSLTTITLDEALQLLSLPRVVGVDPDTGTEITANNGRYGPYLKKGTDSRTITSEEQLLTITLDEALEIYKQPKRGRGATASAPLRELGVDPTSEKPIVIKDGRFGPYVTDGKTNRTLPKDATVESVTFEQAVELLAEKRAKAPVKRATRTTAKKSTATKKTTTTAAKKTPAKKTTATKKTQS
(870) DNA topoisomerase 1 [Kribbella flavida DSM 17836]
8
MAGATGTKSAAGAPAAAAGRRLVIVESPKKARMIAGFLGSGYVVESSFGHIRDLPKGADEIPAKYKGLPWARLGVNIDDHFDPLYVVPADKKAQIRKLKDLLKDADELYLATDEDREGEAIAWHLLDELKPKVPVKRMVFHEITPKAIQDAVGSARQINDALVDAQEARRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVAIRMVVDRERERIAFRSASYWDLDATLDAGEGKTPRLFPSRLVSVDSRRVAQGRDFAPTGELKSQNTVHLDEPTATALAAALAESRFTVRSIESKPYTRKPYAPFRTTTLQQEAGRKLGMSASQTMQIAQRLYENGNITYMRTDSVTLSDTAITAARAQVRELYGASYLPDKPRVYTSKVKNAQEAHEAIRPAGEVFQTPAQTGLSGPEYRLYELIWMRTIASQMKDAAGNSVSIKIDATASTGENCEFTSSGRVITFHGFLKAYVEGADDPSHETDDRETQIPDVAEGDVLPATEVLASGHETKPPSRFTEATLIAQLEEREIGRPSTYASILGTIQARGYVYKKGNALVPAWLAFAVVRLLEQHFTRLVDYAFTASMEDVLDDVAAGNLQREGVLGRFYFGDDDLEGLQSMVSDLGDIDAREMSTFGVGPPDSGIVVRVGRYGPYVEGPDETRANVPEDLPPDELTVDKAKELLSQPSGVEVELGTTPDTGLKVIAKAGRYGPYVTEVLPEGAPKSAKPRTGSLLKSMSLDTVTLDDALKLLSLPRVVGKDPESGDEITAQNGRYGPYLKKGTDSRSLQSEEQMFDITLDEALKIYAEPKQRGRRAAAPPLKELGEDPESGKPVVVKEGRFGPYVTDGETNATLRKDDSVDTISLLRAAELLADKRARGPVKKTAKKAPAKKTAAKKTTAKKATAKKTAATGATKKTAAKKTTKKAAAKKS
(182) DNA topoisomerase 1 [Mobiluncus curtisii ATCC 43063]
8
MAEANQKLVIVESPAKARTIGKFLGEDFDVEASVGHIRDLAQPSDLPATLKKTGYAKFAVDLDHDFEPYYVIDGDKKKKVSELKARLKDADELLLATDEDREGEAIAWHLLEVLKPKVPVKRMVFHEITKDAINRALDNPRELDTDLVNAQETRRILDRLVGYEVSPLLWRKIRTGLSAGRVQSVATRMIVDRERDRMQFKSAEYWDLVAWLTPAAGGTEFSATLREVDGKRIATGKDFDEHGELKSAAQKSGVFALDGTAAQSLDDALSESATWSVDDIDSKPYRRRPPAPFTTSSLQQEASRKLRLNSRDTMRVAQSLYENGYITYMRTDSVNLSEQAISAARSLAVSRFGNDAVPDKPRVYETKTKGAQEAHEAIRPAGEKFQLPSSLEGKLDPREWKLYNLIFRRTLACQMNDATGTTVSVKIAAVPADGSVRAEFGASGTVIENPGFLSAYEEGRDEGDEPAATPGGGKTGEARLPRMQAADRLQLDHLDSGEDRQHFTTPPARYTDASLVKAMEEREIGRPSTYASTISTIVDRQYVYRRGQALVPSWLAFSVVKLLEENLPGLIDYDFTADMEADLDKIAAGKADRTQWLKNFWYGQGKGSDLQGLGLQRAVAELGDIDAAALNTVELGEGIALRVGRYGPYLQRGEERASVPDTVAPDELTLQVAKELLEKGAQGDRVLGVHPETGLEIVAKNGRFGPYVEELQPEPQAETDGETKPKKTAKKKTKNRTSSLLKTQSLDTLTLEDALQLLSLPRTVGQDSEGVDIVASNGRYGPYIKRGTDTRSLESEEQLFTLTTEQALALLAAPKTRGRAATSQTVMMEFGEDPETGQKVTLKNGRYGPYVTDGTTNATVPRGTDPATLTESAAFELLAIKRAKGPTKKRKAPARKTTAKKTAKKTTAKTAKK
(1365) DNA topoisomerase 1 [Micrococcus luteus NCTC 2665]
8
MSTPPASVTASVPEGKKLVIVESPAKSKSIAKYLNAVGSGWVVDSSVGHIRDLPKPSDLPADMKKGPFGKFAVDTEHGFTPYYVVHPDKKKKVTELKRELKDAEALYLATDADREGEAIAWHLLDTLKPTVPVYRMTFGEITQEGVRRGLENIRELDTALVDAQETRRILDRLFGYELSPVLWRKVSRGLSAGRVQSVATRLVVERERERMAFVSAHYWGVEGTFTVAEGAQAADAVGSSFTARLSTVDGERVATGRDFDDAGRLKASAGKKVTHLDEAGARSLAEGLRGADFTVDSVEDKPYTRRPAAPFTTSTLQQEAARKLRMSSRVSMQVAQRLYENGYITYMRTDSVNLSQEAVQAARRQATELYGADAVPAQPRVYAKRNETAQEAHEAIRPAGDSFRTPAQVKAELRPDEFRLYELIWKRTVASQMADAKGYTATLRLSAAAQDGRLAQFSASGTVITFKGFLDAYEEGRDAEVDGENAEAKDRRLPQVAQGERLTGDPIEATGHETSPPARYTEASIVAELERREIGRPSTYAPTISTIMDRGYVSKRGTALVPSWTAFAVIGLLEDYFATYVDYDFTARMEDDLDRIAAGELGREAWLQTFYFGAPAAETEKGVEGLKHVVDNLGEIDARAVNSLPITEDITLRVGQYGPYLERSLPADAEAGATPPRANVPEDLAPDELTPAKAEELFATARPSERELGTDPETGRTVVAKDGRYGPYVTEVIPEMTEEELQAWLDAQPTEYYKNGKPKPKKKPAKEKPRTGSLFTSMSVDTVTLEQALQLMSLPRVVGADAEGEVITAQNGRFGPYLKKGSDSRSLESEDQIFSITQEQALEIYAQPKQRGRGAAKPPLAEFGEDPVSGKKVTVKEGRFGPYVTDGVTNITVPRDRQPEELTAEEAYQLLADKRAKGPATRGGAKKPAARKAPAKKTTARKKA
(563) DNA topoisomerase 1 [Arthrobacter arilaitensis Re117]
8
MPPKAKEKTGKKLVIVESPAKVKSIAKYLGEGFDVDASVGHIRDLPQPSELPTELKKTSVGKFAVDLDNDFEPYYMVYPDKKKRVSELKAKLKEADELYLATDADREGEAIAWHLLQVLKPKVPVRRLAFTEITKEGIARALENMRELDTDLVDAQETRRVLDRLYGYEISPVLWRKVARGLSAGRVQSVATRLVVERERERMAFIPAGYWDVKGNFATSEGEGFAAKLSAVDGARVASGRDFDDRGQLKTTRSKLAHLDQDSAQSLVANLSDTDFAVTSVEDKPYTRRPAAPFTTSTLQQEASRKLRWSSKITMQIAQRLYENGYITYMRTDSVFLSGEAVNAARKQATELYGADSVPAKPRVYKAKNDAAQEAHEAIRPAGDMFRRPKDVRSSLSKDEYALYELIWKRTVASQMADAKGFTATIKLQGTASDNRVAEFSASGTVITFRGFLSAYEEGKDEQALEAAAENAEARLPQLRVGQHLAGDELIALGHETTPPARYTEASIVAELEKREIGRPSTYAPTISTIMDRGYVTKRGGALVPSWIAFSVIRLLEEHFAKYVDYDFTARLEDDLDEIAKGQRARTDWLNLFYFGKGAEAQGEGLKHVVDNLGDIDARAINSIKITDDITLRVGKFGPYLERAIPEGAEEGTDPQRANVPEDLAPDELTAEKAEELFANSQVSEMDLGTDPETGRKIVAKDGRYGAYVTEIIPEPTAEELAAQPVEYYKNGKPKPPKKPTKVKPRTASLFKSMTVESVTLEEALKLMSLPRVLGADAEGEEITVQNGRFGPYLKKGSDSRSIESEEQIFTITLDEALAIYAQPKQRGRRAAVPPLAEFGVDPTSEKNIVVKDGRFGPYITDGITNITVPRTTSLEELTREQAIELLADKRARGPVKRTAKKAPAKKPAAKKAPAKKTTAKKTTAKKTD
(1559) DNA topoisomerase [Rubrobacter xylanophilus DSM 9941]
7
MRLIVAEKPSVGRDIAGALGRHRREGDALVGSGWVVTWALGHLAELAPPDAYGAEYKRWSLQNLPILPERFRVRVNPRTRERFEAVRRWMRDPSVTEVVNACDAGREGELIFAYLYQLSRCEKPVRRLWVSSLTPEAIREGFGSLRDGPSMKPLEDAARSRAEADWIVGMNATRAYSVRFSRPGDVLSVGRVQTPTLRLLVEREREIEDFRPERFFTVHARFARDGKTYDGLWFREKESRLKEREAAEQIAEKVRGGTGVVKKAERRRTSERPPLLYDLTELQRNANARYGFTAERTLRAAQALYEERKLITYPRTSSRYLSGDMVGTLKRRVEAAGGLPELAPFAGRLLAAGSLPVGRRVVDDSKVTDHHAIVPTDRKPSGGLPPDEAKVYDLVARRFLAVFFPAARFENTTVVTEARGETFLSKGRVVLEAGWRELYPDGVGGRKEKEPPALPPVEAGQEWRVAKVGVKEGETKPPPRYSESALLGAMETAGKLVEDEELRQQMKDSGLGTPATRAAIIERLIKVGYVEREKKALVPTAKGRALISLLADSPLSSPEMTARWERRLARIERGEERRPDFMSDISGFAASVVEGVRRMEGEKIAAPGGGGEALGACPKCGSPVVETKKAYGCSAWRKTGCDFAIWKRVAGKRVSESQARQLLAKGRTARLKGFKSRAGKPFSAALVLDGEHRVRLEPFRG
(374) DNA topoisomerase 1 [Rubrobacter xylanophilus DSM 9941]
3
MRLIISEKANAARKIAQFLAEGPVKEGKHRSVPYHTFTWRGEECVSVGLKGHVLNPEYPEEYSNWQKVDPRELIDARILKSVSEKGVAAAVRSLAKKADRVIIATDFDREGELIGVEALSLAFEANPALMDHVERARFSALTKGEVTRAFENLVEVSRELADAGEARQDIDLIWGATLTRWVSRAVKRYGSAFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQNGGGPFVARHARGRFKEEAEARRALENLSETAVVTEVRQREATRPAPAPFNTTAFLTAAANIGVSPSRAARIAEDLYTEGYISYPRTDNTVYPESLDLREVLGFLAEVEGVGDYAGRLLGAGRLTPTRGRRQTTDHPPIYPTGRASRAELREDQWKIYQLVVRRFLATLSGPAKTLRTTLRFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEELPRLSEGDEVRVAEAELLAKETQPPGRYGQGRLIRLMEDLGLGTKATRPGIIQNLYDRGYIHGDPIVPTETGMAVAKALKDFASEIASHEMTARLEKSMDAISEGRVSKDSVVEESRELLRRVYDHLESSEEKFADIVWNGIRGDETLGPCPNCGRNLVVRRNRRNRKRFAGCEGYPECRTTFPLPQKGDIIPLGTACEACGLPEIKVLGGRRPWVTCINMDCPKKQEQRRSREETQAGGEEPSEGQRDRKRLEKSTT
(177) DNA topoisomerase 1 [Arthrobacter chlorophenolicus A6]
8
MPSKAKTGKKLVIVESPAKSKTIAKYLGEGFIVEASIGHIRDLPQPSELPAELKKTSVGKFAVDIDHDFKPYYVVSPDKKKKVTELKAALKDADELYLATDGDREGEAIAWHLLEVLKPKVPVYRMTFGEITKEAIQRAMGNLRDVDQDLVDAQETRRILDRLYGYEISPVLWRKVARGLSAGRVQSVVTRMVVDRERERMAFKAASYWDLTGQFGADSGSFKAKLASVDGAKVATGRDFNDDGVLTSKNVAHLNEELAGSLAAGLQDAPFTVRSVETKPYTRRPAAPFTTSTLQQEAGRKLRFSSKSTMQIAQRLYENGYITYMRTDSSALSDEAVTAARRQASELYGPEYIPGSPRVYSNKAANAQEAHEAVRPAGDSFRTPAQVASQLRGDEFRLYELIWKRTVASQMADAKGSTATIRLGAVAVSGDAAGRDAEFSASGTVITFPGFLAAYEEGKDESRGDDDSDEARRLPNVAKGDSLKASDIVAVGHETSPPPRYTEASLTAELEKKGIGRPSTYASTISTIQDRGYVRKQGSALVPSWIAFSVIRLLEQHFSDYVDYEFTADMEGDLDKIANGQAAGTSWLRHFYFGEDSDPGLLSIVNNLGEIDAREINSIPITDQITLRVGKFGPYLESSAATVDPKTGEIVESPRANVPEDLAPDELTAAKAVELMETAAPEERVLGADPHTGHTVVAKNGRYGAYVTEVIPEMTEEQIAAQPVEYYKNGKPKPPKKPVKAKPRTGSLFKSMTVESVTLDEALQLMSLPRALGEDSEGNLITVQNGRFGPYLKKGTDSRSIGTEEEIFTITLEQALEIYSQPKQRGARAAVPPLAEFGPDPVSEKNIVVKEGRFGPYITDGITNITVPRATSLEELTREQAVELLAEKRAKGPVKRTATRKAPAKKKATAKK
(1843) DNA topoisomerase 1 [Kocuria rhizophila DC2201]
8
MASKATKNEGTGKSLLIVESPSKVKTIAGYLGDAYEVESSMGHIRDLPQPSELPTDMKKGPYGKFAVDVEHEFDPYYVVNPDKKKKVTELKRKLKDADALYLATDGDREGEAIAWHLLQVLKPKVPVYRLTFPEITKEAIERGFGQLRDIDQDLVDAQETRRILDRLYGYEISPVLWRKVAAGLSAGRVQSVATRLVVQRERERIAFVPADYWDLTGQFSRPEGQDAGRAFSARLSSVNGRRVATGKDFDDRGQLKSPSSGNAPVTLDEAVATALAAGLQDAPFSVRSLETKPYTRRPAAPFTTSTLQQEAARKLRFTSRTTMRVAQRLYENGYITYMRTDSVALSDQAVNAARAQAKELYGPEFVPSSKRVYASKSKNAQEAHEAVRPAGDTFRTPSQVRSQLSVDEYKLYELIWKRTVASQMQDAKGDTATVRLGATATSAAGEHAGADAEFSASGTVITFRGFLAAYEEGRDVNPDLTADSGKKGAKDEDKRLPVMAEGDALDASEVTADGHTTTPPARYTEASLVKTLDELGIGRPSTYAATISTIMDRGYVQVRGSALIPSWLAFSVVRLLEDHFSDYVDYDFTAELEDDLDRIARGEAERVKWLSGFYFGENPSEPGLKPIVDDLGEIDARAVNSIPITDEITLRVGKYGPYLEAGGTVDPETGEITDPVRANVPLDLAPDELTPEKAQELMEIGKADGRELGVNPANGRTIVAKDGRYGPYVTEIVPEPTQEELDAIPTEYYKNGNPKPKKIEKPKPNTASLFSSMNLQDITLDDALKLLSLPRELGQDTDGETITVQNGRYGPYLKKGSDSRSISSEDQIFTITLEEAKTIYAQPKQRGRQAARPPLADLGADPLTEKRMVIKEGRFGAYITDGETNVTVPRAEAVEQITAARASQLLAEKRAKGPAPAKSPARGKARTASKSSTSKASASKGTSSKAKAGTTTAKRASATKAKSTTGAARTTRKAPAKKSS
(1227) DNA topoisomerase 1 [Rothia dentocariosa ATCC 17931]
8
MRRAVPTKAKNGKALLIVESPSKVKTISGYLGNEFLVDSSMGHIRDLPQPSELPENLKKGPVGKFAVNIDDDFDPYYVVNPDKKKKVAELKRKLKDVDALYLATDGDREGEAIAWHLKEVLKPKVPVYRMTFPEITREAIERAFGELRDIDLHLVDAQETRRILDRIYGYEISPVLWRKVGRGLSAGRVQSVATRLVVERERERMAFVAANYWDLTGHFITTSNEGFDAKLVAVDGTRVATGKDFADDGTLTSTKVTHLSEADARTLAEALTAAPFAVRSVETKPYKRRPAAPFTTSTLQQEAARKLRFSSRVTMQVAQRLYESGYITYMRTDSVALSDQAVKAARRQASELYGTEYVPSAPRTYASKSKNAQEAHEAIRPAGDKFRTPDAVRGTLSNDEYRLYELIWKRTIASQMADATGSTASVRLGATASNGRDAEFAASGTVITFRGFLAAYEEGVDATRLAERDAKNAEKRLPALAQGDSLTAEKLEATGHETLPPPRYTEASLVKTLDELGIGRPSTYAAVISTIMDRGYVQVRSGSLVPSWTAFSVVRLLETSFGPYVNYEFTAQMEEDLDRIARGEESRVEWLGDFYFGGGVQKKRGLKPIVDNLGDIDARDINSIRIADGIVLRVGKFGPYLEAEGTVNTETGEVSDPVRANVPTDLAPDELTAEKAKELLEQGKSDGRVLGTDPASGNQIIARDGRYGPYVTEVIEEMTEEQIQAYLDAQPTEYYKNGKPKPKKKPKPAKPRTASLFKSMDLATLTLEDALKLLSLPRVLGTDAEGNEITVQNGRFGPYLKKGTDSRSIGSEEEIFTITLEQALDIYAQPKQRGRAAAKPPLAELGVDPNSEKNIVVKDGRFGPYITDGVTNITVPRSETIESLTHERAVELLAEKRAKGPAKRKTAAKKTTAKKSTAKKTTAKKSTTAKKTAAKKE
(1408) DNA topoisomerase 1 [Rothia mucilaginosa DY-18]
8
MPAQAKTGKALLIVESPSKVKTISSYLGEDYLVDSSMGHIRDLPQPSELPENLKKSPVGKFAVNVEENFEPYYVVNPDKKKKVAELKRKLKEVDALYLATDGDREGEAIAWHLKEVLKPKVPVYRMTFPEITREAIQRAFGELRDIDLHLVDAQETRRILDRIYGYEISPVLWRKVGRGLSAGRVQSVATRLVVERERERMAFVAANYWDLSGRFLTAASEGFDAKLVAVDGNRIATGKDFADNGTLNTSKVTHLNEEAARALAAALQSAAFSVRSVETKPYKRRPAAPFTTSTLQQEAARKLRFSSRVTMQVAQRLYENGYITYMRTDSVALSEQAISAARRQASELYGAEFVPSAPRVYTSKSKNAQEAHEAIRPAGDTFRTPDAVRGSLSNDEFRLYELIWKRTVASQMADATGSTASVRLGAVASNGQDAEFAASGTVITFRGFLAAYEEGVDASRVAEREAKDAEKRLPNLTTGEALTAEAIEPAGHETLPPPRYTEASLVKTLDELGIGRPSTYAAVISTIMDRGYVNVRSGSLIPSWIAFSVVRLLESSFGPYVNYEFTAQMEEDLDRIARGEESRVEWLGEFYFGGGSKRGLKPIVDNLGEIDARSINSIPIADGIVLRVGKFGPYLEAEGTLDTETGELTEPIRANVPADLAPDELTEEKARELLEQGKSDGRVLGVDPVSGNQIVARDGRYGPYVTEVIEEMTEEQIQAYLDAQPTEYYKNGKPKPKKKPKPAKPRTASLFKSMDLATVTLEQALQLMSLPRVLGTDAEGVEITVQNGRFGPYLKKGTDSRSIGSEDEIFTITLEQALEIYSQPKQRGRAAAKPPLAELGVDPVSEKKIVVKDGRFGPYITDGITNITVPRAESVESLTHERAVQLLADKRAKGPVKRKTAAKKTTTAKKTTAKKTTTRKTAAKKTAE
(1162) DNA topoisomerase 1 [Isoptericola variabilis 225]
8
MPHPRKLVIVESPTKARKIQGYLGDDFEVEASVGHIRDLPQPSELPAEMKKGPYGKFAVDVENGFEPYYEVYADKKQKVRELKRALKEADELYLATDEDREGEAIAWHLIQELKPKVPVKRMVFHEITREAIQRALENTRDLDEHLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVAADYWDVSGSFAPESGEDAGQAFRARLTGLGADRVAAGRDFDDKGRLKVRTGVVHLDEAAANAVVAGLADASFTVRSLETKPYSRKPAAPFTTSTLQQEAGRKLRMSSRQTMRTAQALYENGYITYMRTDSPALSAEATEAARRQAAELYGPEYVPGAPRLYASKNKGAQEAHEAIRPAGDAFRTPAQVARELSGDQFRLYELIWKRTVASQMADAKGSTASVRLGATLGAGAGDLAGTDAVFSASGTVITFRGFLAAYEEGRDVEAPDDAAASGRETRLPRMAEGDALAGTDLAAEGHSTAPPARYTEASLVKALEELGIGRPSTYAATISTIQDRGYVRTRGQALVPTWLAFAVVKLLEEHFDWLVDYDFTAEMEADLDQIAAGDRERVAWLSRFYFGDGSGQTEGWGLRDLVENLGEIDPVSVNSIEIGEGIRVRVGRYGPYVEDLGAEVGEGQNPPRASIPDDIAPDELTVAVARELLAAGADDGRVLGTDPETGHQIVAKAGRYGPYVTEVLPEPELDPNLSATARKKALAALPKPRTASLFKSMTLESVTLDDALRLLSLPRVVGTDPESGEEITAQNGRYGPYLKKGTDSRTLASEEQLFTVTLDEALKIYAEPKRGRGARAATPPLRELGDDPTTGKPIVIKEGRFGAYVTDGETNRTLPRDVTPDSITPERAIELLAEKRAQGPAKKRRTTTTTRKKATTTKKS
(435) DNA topoisomerase 1 [Microbacterium testaceum StLB037]
8
MANGKKLVIVESPTKMKSIQGYLGDDYEVLSSVGHIRDLASKKEIPADKKAAYGKYSIDVENDFDPYYVVNDRKTKTVAELKRALKTADEVLLATDGDREGEAIAWHLLEVLKPKVPVRRMIFHEITKDAIREAAEHTRDLDVSLVDAQETRRVLDRLYGWDVSPVLWRKVGSGREGTALSAGRVQSAATRMVVERERERMAFVSASYWDVEALASQAGSSFTTRLNRLDGAPIARGGDYDDNGQLKKAVVVLDEAQARALADAVTAAGRATVAKVEAKPGTRSPRAPFTTSTMQQEAGRKLSMSAKHAMGVAQRLYEKGFITYMRTDSVALSAQAISAARAQAVSLYGDKAVPANPRVYKSKSKNAQEAHEAIRPSGETFRTPASVASSLDRDEQKLYDLIWKRTVASQMADAKYETTTVTLTVQAGEKVAEFTASGTVYTFKGFLEAYEEGADEKRNGRDADEDQSLPAVTVGDELTVSDVEPKGHSTSPKPRYTEASLVKALEEKGIGRPSTFASIIGVILDRGYVTKRGQALVPSWLAFSVVRLLEEHFADLVDYDFTAALEDDLDAIARGEQRRTEWLKEFYFGSDKQIGLRHIVDNLGEIDARELNSTRITDTATLRFGKYGPYLEVTEPGADPEAKPRIVNIPEDLAPDELTPEKAQELIDAPVAGDRVLGENPENGKLIVVKDGRFGPYVQELEPEEPEEVDAATGEVIEQPKKKTTKKEAAPKPRTASLFRSMSVDTIDLDTALQLLSLPRVVGVDPESGAEITAQNGRFGPYLKKGTDSRSLDDEKQIFDITLEEALAKYAEPKYGARRASSALKEFDADPVSGKPIKLKDGRFGPYVTDGETNATVPRGEDAMAITFERAVELIADKRAKGPAPKKTAARKTTTTRKAPAKKS
(1836) DNA topoisomerase 1 [Leifsonia xyli subsp. xyli str. CTCB07]
8
MWAALAAIEAALGGGATARSSNRSCVQILARSKVPATKKLVIVESPNKMKSIAQYLGDGYEVMASVGHIRDLIEPKNLPPELKKGSLGKFSVDVENEFEPYYVVSDQKKKTVADLKRALKDADELLLATDEDREGEAIAWHLVEVLKPKVPVKRMVFHEITREAIEKARDNTRQIDTALVDAQETRRILDRLYGYEVSPVLWRKVGPGLSAGRVQSAATRLVVDRERERLAFVAASYWGLTAELAPEEAPSFGARLARVDGDRIATGRDFDDHGRLTSGARTLDEVAAQELTEAVRKPSTVVSVAKVDSKPYSRRPAAPFTTSTMQQEAARKLRFSARQTMSVAQSLYENGYITYMRTDSASLSQQATNAARAQAAKLYGPETVPEKPRVYTSKSKNAQEAHEAIRPSGETFRTPAELEKSLRGPELRLYDLIWKRTVASQMADAKGQTASVTVEAAIAEGQLEGTVAEFTESGTVITFRGFLGAYEEGRDEERNASDTGESKLPPLTAGQTLSVQEVAADGHETTPPPRYTEASLVKSLEELGIGRPSTFASIISTIIDRGYVTQRGQALVPSWVAFSVVRLLEDYFGDLVQYDFTAEMEDDLDRIAGGVAARVDWLNSFYFGSDKHMGLRRVIDNLGEIDARSINSIAIEDGVTLRIGKYGPYLELTEPAATEGTSPRRVTIPPELAPDELTPAKARELIEAPVQTDRVLGTNPANGKLVLAKDGRFGPYVTEADPEEPEADQRTGEVIEARKPAKKAAAPKQRTASLFKSMDLASVDLDTALRLLDLPRVVGVDPESGDEIQAQNGRYGPYLKKGTDTRSLPGEDDIFAVDLVGALDLFAQPKYGNRRVSSALKEFDPDPVSGKPIKVKDGRFGPYVTDGETNATIPRGETVDEVDFERAVQLLADKRVKGPAKKTASRASAAKKTTAKPAAAKKTAAATSAAATSTAEKTTAAKKAAAAAKTTASTAAEPTAADAE
(1367) DNA topoisomerase 1 [Kytococcus sedentarius DSM 20547]
8
MAAKGSKLVIVESPTKVKSIGQYLGDEYRVEASVGHIRDLPTPSEMPADMKTGPYGKFAVDVDNGFDPYYVIDADKKKKVTELRKALKEADELYLATDEDREGEAIAWHLLQALKPKVPVKRMVFHEITKDAIQHAVNTTRDLDDRMVDAQESRRILDRLYGYEVSPVLWRKVKQGLSAGRVQSVATRLVVERERARMAFRIASYWDVEADLAPADDQQFTARLTSLDGVRVATGRDFTDAGELKSSAQVTHLAEADARAVASGIEAAQVTVTDVSEKPYTRKPAAPFITSTLQQEASRKLRLGSKDAMRVAQRLYENGYITYMRTDSTTLSQSAMTAARQQARDLYGADYVPDSPRFYGKKAKGAQEAHEAIRPAGDTFRTPAQVAGELRGSEYAMYELIWKRTVASQMADAKGSTATVRIGAPLQGVQVGGKPARQAELTASGTVITFRGFLAAYEEGRDADRYGGGEQGGSGDAGAKSGKGAKEVRLPKMAAGQELATSRVEALGHETSPPPRYTEATLVKALEEKGIGRPSTYAATVGTIQDRGYVRTKGNALVPTWLAFAVTTLLEKHFPTLVDYDFTASMEEGLDAIAAGEEDRVAWLQRFYFGDEASSATGLRELVEDLGEIDAKGVSTIDIGDGIVVRVGRYGPYVEEIAPAGTDLTTGEVPDDAGSAARAADGTAASGEEEAKPLRASIPEDIAPDELTPAMAREYLAEAASDGRVLGQDPETGRDIVAKTGRYGPYVSEVFTDEDVARFEAEGKKTTGRGKDLVKPRTGSLLASMDVRTVTLEDALKILSLPRVVGADPESGAEITAQNGRYGPYLKKGTDSRSLASEEQIFEITLEEALKIYAEPKRRGRSAANPPLAEFAEDPVSGKKVVIKDGRFGPYITDGETNVTVPRAMRPEDVSELQAFELLAQKRAEGPKKKPVRKSSGTTRKAPAKKPAAGTARTVKAGSRKKS
(1527) DNA topoisomerase 1 [Intrasporangium calvum DSM 43043]
8
MAAGKGRKLVIVESPGKVKSIASYLGGDYEVEASIGHIRDLPNPSELPAEMKKGPFGKFAVDVDHGFEPYYVVDADKRKKVAELKRKLKDASELYLATDEDREGEAIAWHLLEALKPRVPVKRMVFHEITREAIQRAVNDTREIDQDLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRMVVERERERMAFVRASYWDVEGDFTPDGATQQFTARLSGVDGARVATGRDFADDGRLTGRNVVHVDEALARRIAEACLSVGQGATRVTDVQEKPYTRRPSAPFTTSTLQQEASRKLRMSSKNSMRVAQRLYEGGFITYMRTDSTTLSDAALTAARSQARDLYGAEYVPDAPRRYEKKVKNAQEAHEAIRPAGDRFRTPAMVAGQLRGEDYALYELIWKRTVASQMADARGSTATVKLSVDTAVESARQVEFSASGTVITFKGFLAAYEEGRDDEALARADAAAEERRLPRLSSGVALQVVRAEADGHETAPPARYTEATLVKAMEEKGIGRPSTYASTIGTIQDRGYVYSKGQALVPTWLAFAVTRLLEEHFSELVDYEFTASMEEDLDRIAGGELARVDWLKRFYFGDEASTAEGLKELVDDLGEIDAREISTIPLGDGMVVRVGRYGPYVEETAPHGVDLETGELAAGTDAAEVPTTPRRATINDDIPPDEMTPARARELLEAAADDGKVLGRDPETGREIIARAGRYGPYVTEVLPEPEPELTASGKPKKVAKAKPRTASLFKDMDLGTIDLETALQLLSLPRVVGTDADGVEITAQNGRYGPYLKKGTDSRSLQSEQQLFDITLDQALAIYAQPKQRGRGAATAPLKELGEDPVSGKPVVVKDGRFGAYVTDGETNATLRKDDDPATITPERGFELLAEKRAKGPTTRKRATKKTAKRATKKAPAKRATKKATTKKA
(1380) DNA topoisomerase 1 [Corynebacterium ulcerans 809]
8
MAEKSGPKRLVIVESATKAKKIAPYLGDDYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNTENGFAPLYVVSADKKKKVADLKQKLKLVDELLLATDPDREGEAIAWHLLEVLKPKVPVKRMVFNEITKPAILAAAENTRELDANLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFVSAEYWDIEAEFDTGKPDTDGNPHQFTGRLTSVDGKRVATGRDFNDRGELKGDVVVVDKQRAEALAAELTGAPMSVAKVEEKPYTRRPYAPFMTSTLQQEAGRKLHFTSERTMRIAQRLYENGHITYMRTDSTTLSEQGLKAAREQAISLYGNDYVADGPRRYDRKVKNSQEAHEAIRPAGERFATPGELHSQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTIAGKNAEFSATGRTITFPGFLRAYVEITKLSDGRDLADNAEHHLPRLAEGDALDVNKLEVDEHSTNPPARYTEASLVKKMEELGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEKSFSALVDYDFTSSMEDELDDIAAGREDGTAWLTGFYFGDAEASDATAESIARHGGLKALVGDNLEHIDARLVNSLELFQDSEGRAVNVRVGRYGPYIERQIGVTADGEAEYQRANLSDTTTPDELTLEVAEKLFATPQSGRELGRNPKNDRMIVAKEGRFGPYVTELVNEDERIQVETKAEEIVAAERKAEDEQRAAEGKRAKNWETKTAVKQKEKRIAEIVDETLKPGTASLFKAMEPATVTLEEALQLLSLPREVGVDPSDNEPITAQNGRYGPYLKKGNDSRSLAKEEQIFTITLDEARRIYAEPKRRGRGATSQSVIKELGDNDVSGKPMSVRDGRFGPYVTDGTTNASLRRGDDPTALTDARANELLSERRAKEAADGGTAKATKKTTKKTTAKKAVKKPAKTTKRVVKAGRKK
(1548) DNA topoisomerase 1 [Cellulomonas flavigena DSM 20109]
8
MSAGRKLVIVESPAKARTIAGYLGDGFDVEASVGHIRDLPQPSELPADMKKGPYGKFAVDVENGFTPYYVVDADKKKKVAELKKLLKESDELYLATDEDREGEAIAWHLLAELKPKIPVKRMVFHEITREAITRALENTRELDERLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVAADYWDVTGTFAVADDSEPTFSARLTGVGGARVASGRDFDDRGALKTRDTVVLDETRAHALVAGLDGAAFTVQSLETKPYTRRPAAPFTTSTLQQEASRKLRMSSRQAMRTAQTLYENGYITYMRTDSPALSTQAVDAARRQVAELYGADHVPDKPRVYTSKAKGAQEAHEAIRPAGDHFRTPAQVARELSGDQFKLYELIWKRTVASQMADARGQTASVRLAATARTADGPVETVFSASGTVITFRGFLAAYEEGRDRGRYDEAEGGASGSDDARLPQMAQGDPVTGSDLTADGHRTSPPPRYTEASLVKALEERGIGRPSTYAATIGVIQDRGYVTNRGQALVPTWLAFAVTRLLEENFDRLVDYNFTAGMEESLDAIAAGQKGRVDWLTEFYFGDRSDSVASGGLRGLVDNLGEIDAREVNSIEIGDGITLRVGRYGPYLEAPGEGPDDEPRRSSVPDDLAPDELTVAKARELLETMPDGDKVLGTDPGSGHQIVARNGRYGPYVTEVLPEPELDPGLSAAARKKALAAAPKPRTGSLFKSMSLATVTLDDALRLLSLPRVVGADPETGAEITAQNGRYGPYLKKGTDSRTLASEEQLLTITLEEALAIYAQPKRGRGQTAAAPLRELGTDPTSGRPIVVKDGRFGAYVTDGETNRTLPRDVTPESITPEQAVELLAEKRAAGPAKKKTTTRKTTTRQKSAAKS
(425) DNA topoisomerase 1 [Corynebacterium pseudotuberculosis 3/99-5]
8
MPFPALLVFLDACVGQRCVVDPYYKVPTHFYRAFCELRFSPFMAEKSGPKRLVIVESATKAKKIAPYLGDDYIVEASVGHIRDLPRGAADVPTKYKKEPWARLGVNTENGFAPLYVVSPDKKKKVADLKQKLKLVDELLLATDPDREGEAIAWHLLEVLKPKVPVKRMVFNEITKPAILAAAENTRELDANLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFVSAEYWDIEAEFDTGKPDTDGNPHQFTGRLTSVDGKRVATGRDFNDRGELKGDAVVVNKQRAEALVAELTGAPMNVAKVEEKPYTRRPYAPFMTSTLQQEAGRKLHFTSERTMRIAQRLYENGHITYMRTDSTTLSEQGLKAAREQAISLYGNDYVAEGPRRYDRKVKNSQEAHEAIRPAGEHFATPGELHAQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTIAGKNAEFSATGRTITFPGFLRAYVEITKLSDGRDLADNAERHLPRLAEGDALDVNKLEVDEHSTNPPARYTEASLVKKMEELGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEKSFSALVDYDFTSSMEDELDDIAAGREDGTEWLTGFYFGDAAASDATAESIARHGGLKALVGDNLEHIDARLVNSLELFQDSEGRAVNVRVGRYGPYIERQIGVSADGEAEYQRANLSDTTTPDELTLDVAEKLFATPQSGRELGRNPKNDRMIVAKEGRFGPYVTELVNDDERAQVEAKAEEIVASERKAEDEQRAAEGKRAKNWETKTAVKQKEKRIAEIVDETLKPGTASLFKDMEPATVTLEQALQLLSLPREVGVDPSDNAPITAQNGRYGPYLKKGNDSRSLASEEQIFTITLDEARRIYAEPKRRGRGATSQSVIKELGDNDVSGKPMSVRDGRFGPYVTDGTTNASLRRGDDPTELTDARANELLSERRAKEAADGGAEKKATKKAAKKSTKKTTAKKAVKKPAKTTKRVVKAGRKK
(1825) DNA topoisomerase 1 [Corynebacterium variabile DSM 44702]
8
MGAQGSVSGGKKFVIVESATKAKKIQKFLGDGFIVEASVGHIRDLPRGAADVPPKYKKEQWARLGVNVDDDFQPLYIVSPDKKKKVADLKAKLKQADELLLATDPDREGEAIAWHLLEVLKPKVPVRRMVFHEITPEAIREAAENTRELDFDLVDAQETRRVLDRLYGYEISPVLWKKVMPRLSAGRVQSVATRVIVRRERERMAFVRAGYWDLTATLDTGDRGQDATTNPRKFDANLVAVDGARVAQGRDFNDDGKLKTGKAQANVTVLDKARAEALSSALTGTTMAVTNVEEKPYTRRPYAPFMTSTLQQEAGRKLHFTSERTMRIAQRLYENGHITYMRTDSTTLSASGISAARQQAKELYGPSFVADAPRQYTRKVKNSQEAHEAIRPAGETFNTPGALASQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTVSGEATSGEAVDFQATGRTITFPGFLKAYVETTRTADGRDVADNAEKALPVLTVGDALDAAEIAAKGHETQPPARYTEASLVKTMEELGIGRPSTYASIINTIKDRGYVVSRGSALVPSWTAFAVVGLLENNFGSLVDYEFTSSMEDELDEIARGEENRSHWLKGFYFGDPEASDATAESVARLGGLKHLVNDNLEQIDARKVNSLHLFDDANGVPVVVRVGRYGAYLERIIPAEPGATTESGEPAEPTVQRANLPEALLPDELTLEVAEKLFATPQGGRELGVNPANGRVIVAREGRYGPYVTEKVKDDEEARVTAEAEKVIDAERDAEDAARAEEGKKPLSRETKTAENKKAKRIKEILEETLKPKTASLLKTMDPATVTLEDALKVMSLPREVGVDPSDGEMITAQNGRFGPYLKKGNDSRSLASEEQIFTVTVDEARRIYAEPKRRARAAAKPPLKQLGDNDVSGKPMTVKEGRFGPYVTDGETNASLRRGDTPETMTDARGNELLSERRAKEAADGGASKKSAKSARKTTKKATAKKTTAKKTTAKKTTAKKTTKKAAAKKS
(520) DNA topoisomerase 1 [Corynebacterium kroppenstedtii DSM 44385]
8
MKRLVIVESATKARKIQPYLGSDYIVEASVGHIRDLPRGAADVPAKYKKKPWARLGVDVENDFAPLYVVNQDKKKKVADLKAKLKQVDELYLATDPDREGEAIAWHLLQVLKPKVPVRRMVFHEITKPAILEAAKHTRELDQNLVNAQETRRVLDRLYGYEISPVLWKKVMPRLSAGRVQSVATRVIVERERDRIAFTSADYWDLTGTFALRSGADASTPGSSTAGADTASGEPRSFPARLAEIDGQRVAQGRDFNDDGQLKSKAVALDEKAAKDLADQLSGAAMSVRSVEEKPYTRRPYPPFMTSTLQQEAGRKLHYTSERTMRIAQRLYENGHITYMRTDSTTLSESGINAARAQARELYGAKYVASAPRQYSRKVKNSQEAHEAIRPAGESFATPGQLGGQLDAEEFKLYELIWQRTVASQMADAKGTSMKVFVAGESTDGRDCVFTATGRTITFPGFLKAYVEVSRTADGRNVADDAEKRLPVLTEGQGLTATDIEADGHSTTPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEQNFGSLIDYDFTSSMEDVLDSIANGSEDRSHWLEGFYYGDDGASSAKAETIARLGGLKHLVGGNLETIDARAVNSLHMFDDEDGNPIVVRVGRYGPYLERTPAGSDEPQRANLPDTVTPDELDLALAEKLLATPPTGRELGENPANGRMVVAKEGRYGPYVTELVRDDEREKAEAKALETVDAEWDADDEARKAEGKKPLNRETKTAAKKREKRVNELVTEMLKPKTASLFSGMEPSTVTLDEALKLMSLPREVGVDPSDGEVITAQNGRYGPYLKKGTDSRSLANEEQIFTITLDEARRIYAEPKRRGRAAAKPPLKQLGDNDVSGKPMTVKEGRFGPYVTDGETNASLRRGDTPEAMTDARACELLSERRAKEAANGGAKKKSSKKGTRKSTKKSGRKSTSKASKKTSKKSPAKKTVKS
(1086) DNA topoisomerase 1 [Mycobacterium gilvum PYR-GCK]
8
MADGDRGSGKNGSVRRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPDKKATVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQATPPTFVAKLNTVDGRRVAAGRDFDSLGAVKKPGEVLVLDEAAANALAGGLRGAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRMSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSQLDTDEFRLYELIWQRTVASQMADARGTTLSLRIAGAATSGEQVVFNASGRTITFAGFLKAYVESLDEQAGGEADDAESRLPNLTQGQRVDAKDLTADGHTTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFSRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGEHGVEGSIAREGGLKKLVGGNLEEIDAREVNSIKLFDDSEGRAVNVRVGRNGAYLERMVADPDNPGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGIDPATGHEIVAKDGRYGPYVTEVLPEPPDDGEAGATAKKGKKPTGPKPRTGSLLRSMDLETVTLDDALRLLSLPRVVGVDPANGEEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPVKKKAAKKAAVKKTAAKKAAKKAPAKKAAKKA
(781) DNA topoisomerase 1 [Corynebacterium resistens DSM 45100]
8
MAKDDLKRLVIVESATKARKIAPYLGPNYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNVDKEFEPLYVVSADKKKKVSDLKAKLKQVDELYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFHEITKPAILAAAEDTRELDQDLVDAQEARRVLDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFVSAEYWDLTAKLNLQTAGLDGEPNSFEARLATVGGKRVAQGRDFNDDGQLKSEAVVLDGGSANALATDLTGSDMQVTGVEEKPYTRRPYPPFMTSTLQQEAARKLRFTSERTMRIAQRLYENGHITYMRTDSTTLSQSGMQAARAQAKELYGAKFVANAPRQYNRKVKNSQEAHEAIRPAGETFDTPGQLAGKLDAEEYKLYELIWQRTVASQMADAKGMSMKVTVAGSSSQAAEVPGITSTEVEFTATGRTLTFPGFLKAYVEVSSTGDGKDMADNAEKRLPVMSQGDALKASEVTAEGHTTNPPARYNEASLVKRMEELGIGRPSTYASIIRTIQDRGYVLPRGNALVPSWVAFAVVGLLEQNFGSLVDYDFTSAMEDELDAIAEGRTDRANWLRGFYFGDDSRDKDSPSSAIPRQGGLQHIVGDNLEQIDARRVNSLHLFDDAEGNPIVVRVGRYGPYLERVKPVPAGAPEGTEPEVQRANLPESMTPDGLTLDVAEKLFATPQGGRELGVNPESGRTIVAREGRYGPYVTELLGEDEEAQAAAKAEAQWEAERDEQDREREAEGKKPLSRETKTAQNQKAKRVKELVEASLKPKTASLFSDMEPASVTLEEALKLMSLPREVGVDPSDGEMITAQNGRFGPYLKKGSDSRSLANEEQIFTVTLDEARRIYAEPKRRGRAAAKPPLKQLGDNDVSGKPMSVKEGRFGAYVTDGTTNASLRKGDTPETITDARANELLSERRAKMAAEGTAPAKSARKAAKKSTRKTSAKKTTKKAGAKKTGTKKSTKKAPPTLTKRTVKRSH
(1056) DNA topoisomerase 1 [Nocardia cyriacigeorgica GUH-2]
8
MIVESPTKARKIAPYLGRNYTVEASVGHIRDLPRGAADVPAKYKGQPWARLGVDVDHDFEPIYVVSPDKKGKVTELKSLLKDADELYLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIQAAAADTRDLDSDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVRRERERMAFRSAEYWDIAAKLDAGETGEVGNPRTFGARLVNVDGARVASGRDFGSDGQLKADSGVVVLDEAYARRLAEALDGADLVVSSAEAKPYSRKPYAPFMTSTLQQEAGRKLRFTSERTMRVAQRLYENGYITYMRTDSTTLSQSAINAARSQATQLYGAEYVHPTARQYNRKVKNAQEAHEAIRPAGDTFATPGELHARLDNDEFRLYELIWQRTVASQMADAKGTTLTLRITGVAGTGEECVFSASGRTITFPGFLKAYVESVDEEAGGQSDDAESRLPALAEGQGVTAVELNPDGHSTNPPARYTEASLIKALEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVVGLLEEHFGRLVDFDFTAAMEDDLDAIAGGREQRGNWLSSFYFGGDHGADGSVARSGGLKKMVGDRLDDIDAREVNSIKLFTDAENRDVVVRVGRYGPYLERMVTNPDDPEGDSISQRANLPDDLPPDELTPEVAEKLFATPQEGRSLGTDPATGHEIVAKEGRFGPYVTEILPEPAEEPAPAKKTAKKAAAPKPRTGSLFKSMDLATITLDDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKKGTDSRSLADEDQIFNITLDEALKIYAEPKRRGRQAASAAPLRELGNDPASGKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDERAAELLADRRARGPVKKAAKKTTKKAAAKKTAAKSTAAKKTAAKKTPAKKAPAKKSAAKAVSD
(1803) DNA topoisomerase 1 [Rhodococcus erythropolis PR4]
8
MAKADNGSGQGASGNPRRLVIVESPTKARKIAPYLGKDYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDHDFEPLYVVSPEKKGKVAELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAEDTRELDTDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRVIVQRERERMAFKSASYWDISATLDAGAEASPRSFGARLVSVDGSRVASGRDFGADGKLKGSAVTVLDEAYARRLAEALQGVDLTVSSAEDKPYTRKPYPPFMTSTLQQEAGRKLRFTSERAMRIAQRLYENGYITYMRTDSTTLSESAIAAARAQATELYGPEYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSKLDSDEFKLYELIWQRTVASQMADARGTTLTLRISGTAGTGEDCTFSASGRTIVFAGFLKAYVESVDEEAGGQSDDAESRLPVLVKGQEVTATKLDPDGHSTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVIGLLEVHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGETGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPEPPAEPEPDIVPVSAPEPEEISSGSTKTAVKKAAAKKAPAKKAAKKVAGPKPRTGSLLKSMDLATITLEDALRLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLANEEQMFTVTLDEALKIYAEPKRRGRQASATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKDDDVESISDARASELLADRRARGPVKKKAAAKKAPAKKAAAKKTAAKKAPAKKAAAKKAPAKKDS
(1202) DNA topoisomerase 1 [Rhodococcus equi 103S]
8
MASREKSTADGASGTRRLVIVESPTKAKKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGEPWARLGVNVDHDFEPLYVVSPEKKSKVTELKSLLKDADELYLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAEDTRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRVIVQRERERMAFRSAEYWDISATLDAGADASPRAFGARLVSVDGSRVAAGRDFGPDGKLKSTGVTVIDEAYARRLAEALEGVDLVVSSAEDKPYTRKPYAPFMTSTLQQEAARKLRFSSERTMRVAQRLYENGYITYMRTDSTTLSQSAISAARAQATELYGAEYVHATPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLENDEYRLYELIWQRTVASQMADARGTTLTLRITGTAGTGEECTFSASGRTITFPGFLKAYVESVDEEAGGQSDDAESRLPVLTQGQEVTATKLDPDGHSTNPPARYTEASLIKALEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVIGLLETHFGRLVDFDFTAAMEDDLDEIAGGREQRGNWLSSFYFGDAAAADDSIARAGGLKKMVGQNLEDIDAREINSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPDGDPVSQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPEPAPEPEPDIVPVEAAADGTTKTKAVKKAPAKKAAKKVAGPKPRTGSLLKSMDLATVTLEDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLENEDQMFTVTLEEALKIYAEPKRRGRQASAAAPLRELGNDAATGKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDERASELLADRRARGPVKKKAAAKKAPVKKAAAKKTAAKKAPAKKAAAKKS
(208) DNA topoisomerase 1 [Mycobacterium sp. MCS]
8
MKNWSRIQLADGSPRGGNGGGEPPARRANGSVRRLVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVDVEHDFEPLYIISPDKKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERERMAFRTAGYWDVSAELDASVSDPQATPPTFTAKLNSVDGRRVATGRDFDSLGQVRKPDEVLVLDEAAAGALAAGLQAAQLSVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTARQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHAQLDTDEFRLYELIWQRTVASQMADARGTTLSLRIAGDSRDGQSVVFSASGRTITFAGFLKAYVESIDELAGGESDDAESRLPNLTQGQRVDAKELTPAGHQTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFGRLVDYGFTAAMEDELDEIASGTERRTNWLKNFYFGGEHGVGDSIARAGGLKKLVGVNLEEIDAREVNSIKLFDDAEGRPIYVRVGKNGPYLERMVADEENPGELKPQRANLKDELTPDELTLELAEKLFSTPQEGRTLGVDPETGHEIVAKDGRYGPYVTEVLPAPPEEPEDGAPAKKGKKPTGPKPRTGSLLRTMDLETVTLDDALKLLSLPRVVGVDPNTGEEITAQNGRYGPYLKRGTDSRSLATEEQMFTITLDEALKIYAEPKRRGRQGAATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVMSITDARASELLADRRARGPVKKKAAAKKAPAKKTAAKKTAAKKASAKKA
(1070) DNA topoisomerase 1 [Rhodococcus opacus B4]
8
MAKGDNGSAQGAAGASGQPRRLVIVESPTKARKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDQDFEPLYVVSPEKKSKVTELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAEDTRELDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVQRERERMAFRSASYWDISATLDAGADASPRSFGARLVSVDGSRVATGRDFGSDGQLKTSTVTVLDEARAQRLAESLAGVDLTVSSAESKPYTRKPYAPFMTSTLQQEAGRKLRFTSERTMRIAQRLYENGYITYMRTDSTTLSSSAIAAARAQATELYGAEYVHDTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLDTDEFRLYELIWQRTVASQMADARGTTLTLRITGTAGTGEECTFSSSGRTITFAGFLKAYVESVDEEAGGQSDDAESRLPVLVEGQAVTATKLDPDGHTTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVIGLLEMHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGDHGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPEPEPEPEPAVVPVTDESGDGTTKTKTAAAKKAPAKKAAKKATGPKPRTGSLLKSMDLATVTLDDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATEDQMFTVTLDEALKIYAEPKRRGRQAAATPPLRELGVDSVSEKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDARASELLADRRARGPVKKKAAAKKAPAKKAAKKTAAKKAPAKKAASKKAADKKA
(1127) DNA topoisomerase 1 [Rhodococcus jostii RHA1]
8
MAKGDNGSAQGAAGASGQPRRLVIVESPTKARKIAPYLGKNYVVEASVGHIRDLPRGAADVPAKYKGESWARLGVNVDHDFEPLYVVSPEKKSKVTELKSLLKDADELFLATDPDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAEDTRELDNDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVQRERERMAFRSASYWDISATLDAGADASPRSFGARLVSVDGSRVATGRDFGADGQLKTSTVTVLDEARAQRLAESLAGVDLTVSSAESKPYTRKPYAPFMTSTLQQEAGRKLRFTSERTMRIAQRLYENGYITYMRTDSTTLSSSAIAAARAQATELYGAEYVHDTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSRLDTDEFRLYELIWQRTVASQMADARGTTLTLRITGTAGTGEECTFSSSGRTITFAGFLKAYVESVDEEAGGQSDDAESRLPVLVEGQAVTATKLDPDGHTTNPPARYTEASLIKTLEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVIGLLEMHFGRLVDFDFTAGMEDDLDAIAGGREQRGNWLSSFYFGGDHGAEGSVAREGGLKKMVGVNLEEIDAREVNSIRLFDDAEGREVHVRVGRFGPYLERMVQNPDDPEGDLISQRANLPDDLPPDELTPEYAEKLFSTPQEGRKLGVDPLTGHEIVAKEGRFGPYVTEILPEPEPEPEPAVVPVTDESGDGTTKTKTAAKKAPAKKAAAKKATGPKPRTGSLLKSMDLATVTLDDALKLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATEDQMFTVTLDEALKIYAEPKRRGRQAAATPPLRELGVDTVSEKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDARASELLADRRARGPVKKKAAAKKAPAKKAAKKTAAKKAPAKKAASKKAADKKA
(1014) DNA topoisomerase 1 [Mycobacterium abscessus ATCC 19977]
8
MRRLVIVESPTKARKIAGYLGDGYVVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIVSPDKKGTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPKVPVRRMVFHEITEQAILAAAQDPRDLDNNLVDAQETRRILDRLYGYEVSPVLWKKVGRNLSAGRVQSVATRIIVQRERDRMAFRSAGYWDLGAELDAGKDNPAAKPPRFHARLVSVDALRVASGRDFDSLGQVKETSNGPGVLVLDETRANALVAGLSQATLTVVSAEEKPYTRKPYPPFMTSTLQQEAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSDSALQAARSQAAELYGNEYVHPSPRQYTRKVKNAQEAHEAIRPAGETFKTPGQLHSSLDNDEFRLYELIWQRTVASQMADARGTTLSLRLAGTATSGEQVVFTASGRTITFPGFLSAYVETVDELSGGEADDEERRLPQLRQGQSVTVAELSADGHTTNPPARYTEASLIKALEELGIGRPSTYSSIIRTIQDRGYVHKRGSALVPSWTAFAVIGLLEQHFGRLVDYDFTAAMEDDLDEIASGNERRTNWLNAFYFGGDHGVEGSVARAGGLKRLVGVNLEEIDAREINSIKLFDDDQGRPIYVRVGKNGPYLERMVADPDGEAGALIPQRANVKDGVTPDELTVEMAEQLFAIPQEGRTLGVDPETGHEIVAKDGRFGPYVTEVLPAPPEPVEAEKPKRGAKKVEGPKPRTGSLLKSMTLETVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGTDSRSLATEGQIFTVTLDEALKIYSEPKRRGGQAASAAPLRELGVDSATGKPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDERASELLADRRARGPVKRAKKAPAKAAKKAPAKKAPAKKAAKKAT
(1075) DNA topoisomerase 1 [Mycobacterium ulcerans Agy99]
8
MADPKTKGPGSRSSGGNGSGRRLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSELKDLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRRASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSLWIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPLARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDAESGHEIVAKDGRYGPYVTEILPEPPAPEAGTEAPAKKSKKATAPKPRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKAMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA
(414) DNA topoisomerase 1 [Actinoplanes sp. SE50/110]
8
MPSDARTTRLVIVESPSKAKTIAGYLGPDYLVEASVGHIRDLPKNADEVPAKYKGQPWARLGVDVDNGFHALYVVSAGRREQVAKLQRLAKEVDEIFLATDEDREGEAIAWHLIETIKPKVPVKRMVFHEITKPAIQAAVANPRDIDRSLVDAQEARRILDRLYGYEVSPVLWKKVMRGLSAGRVQSVATRIVVERERQRMAFRSAEYWDIQALLAVQGPVDGPRNFSATLIALDGDRIASGKDFEPTTGQLKPGAAVVQLDGDGARGLAARLADRPFTVSRVEEKPYRRRPYAPFTTSTLQQEASRKLRSSSKQTMSTAQSLYEKGYITYMRTDSVNLSETAIAAARRQIAELYGANNVPPQPRRYTTKSKNAQEAHEAIRPAGDNFRTPGEVAKELNTAEFKLYELIWRRTIASQMTDAIGNSISVRIRAVSTANEEADFAASGKTITDPGFLRAYVESSDDENAEAEDAERRLPNLVKDQPLTADELNALGHHTSPPPRYTEASLVKMLEELGIGRPSTYTSIMQTIQDRGYVEKRGQAMIPTFPAFAVVGLLENHYGRLVDYNFTAAMEGQLDDIASGDHTAVDFLTSFYFGSQAGGADEEIAKAGGLKKMVTEDLSAIDAREVNSIPLFTDDQNRQVVVRVGKFGPYLQRSNTQVADGAEEASEDRASIPEGVAPDELTREKVEELFLAGNGDRTLGDNPATGEPVLVKSGRFGPYVQSGESKSSLFQSQSPQTLTLEQALQLLSLPRVVGKDPEGNEIIARNGKFGPFIQRLKDSRSLESEERLFTVTLDEALAMLAAPKVRGQRGAPKPPLRDLEGVDPVSEKPLLVKDGRFGPYVTDGETNVTLRRGQTPEELTLQEAIEMIAEKRAKGPAPKKAPAKKAAPAKKAAAKAATPAKKATAKKAAPAKKAAPRKAAASSE
(1743) DNA topoisomerase 1 [Salinispora tropica CNB-440]
8
MPSNTGTTRLVIVESPAKAKTISGYLGPGYVVEASFGHVRDLPRNAADVPAKYKGEAWARLGVDVDNGFHALYVVSSDRRQQISKLTKLAREVDEILLATDEDREGEAIAWHLVETLKPKVPVKRMVFHEITKPAIQAAVANPREIDRDLVDAQEARRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERQRMAFRTAEYWDILATLAGEQPGEGPRTFNATLVALNGDRIATGKDFEPTTGRVRPGAGVVHLDEGGARGLAARLADRPFTVTRVEEKPYRRRPYAPFITSTLQQESARKLRFSSQQTMRTAQRLYENGYITYMRTDSVNLSETAIAAARRQIVELYGERSVPPEPRRYTGKVKNAQEAHEAIRPAGDTFRTPGELRNELSVEEYKLYELIWRRTIASQMTDAVGSSVSVRIRAVTAAGEEADFGATGKTITDPGFLRAYVESSDDENAEAEDAERRLPHLVKDQPLTGEQLAAQGHHTQPPARYTEASLVKALEELGIGRPSTYASIMQTIQDRGYVAKRGQAMIPSFLAFAVVGLMERHYPRLIDYGFTASMENELDEIAGGDHAAVDFLTAFYFGITNGAGDQDIARSGGLKKLVTENLSEIDARSVNSIPLFSDDEGRPVVVRVGRYGPYLQRELPGEAAAADGEEGGGQGDRAPIPEGLAPDELTPEKVHELFLGGGGERKLGEDPATGEPILLKSGRFGPYVASGERKSSLLRSQSPDALTLDEALRLLSLPRLVGTDPEGNEVFANNGRYGPYVKRGEEFRSLESEEKMFTVTLDEALALLAAPKTRQRRAPAPPLRELGADPLTEKPLVIKDGRFGPYVTDGETNASLRRGQTPEALSLEQASEMLAEKRAKGPAPRKKAAKKAAPAKKATPAKKATKKAAATKKTAAATKSAKKTATVNSTAAKQAKPKRAGSAAE
(106) DNA topoisomerase 1 [Mycobacterium tuberculosis H37Rv]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(107) DNA topoisomerase 1 [Mycobacterium tuberculosis H37Rv]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(774) DNA topoisomerase 1 [Mycobacterium tuberculosis F11]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASMRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(1617) DNA topoisomerase 1 [Mycobacterium canettii CIPT 140010059]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(929) DNA topoisomerase 1 [Mycobacterium avium subsp. paratuberculosis K-10]
8
MADPKLKENTSGGNGSRRRLVIVESPTKARKLASYLGSRYIVESSRGHIRDLPRAAADVPAKYKSEPWARLGVNVDADFEPLYIISPEKKHTVSELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPNIPVKRMVFHEITEPAILEAAENPRDLDIDLVDAQETRRILDRLYGYEVTPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFRSASYWDIVAQLDASVSDPQASPPTFAARLTSVDGLRVATGRDFDSQGQLRKADEVIVLDEPQATELAAGLQGAQLSVASVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSGSAINAARTQARQLYGEEYVSPSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSLRIGGQAGDRQVVFSASGRTITFAGFLKAYVETVDELAGGEADDAESRLPQLTQGQRLDAIELTPDGHATNPPPRYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDAIASGQERRTDWLNNFYFGGEHGVADSIARSGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPVYVRVGKNGPYLERMVTGDDGEPTPQRANLNDSLTPDELTLEVAEQLFATPQEGRVLGVDPATGHEIVAKDGRYGPYVAEVLPEPPPDDDDGSGAPAKKGKKPTGPKPRTASLLRTMDLQTVTLEDALRLLSLPRVVGVDPETGEEITAQNGRYGPYLKRGNDSRSLASEEQLFDITLEEALKIYAEPKRRGRQGAAAPPLRELGADPATGKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDQRAAELLADRRARGPAKRTAKKTSRKAPAKKAAKRG
(168) DNA topoisomerase 1 [Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1]
8
MATTPRRLVIVESPTKATKIAGYLGPGYVVESSRGHVRDLPTSAAEVPAKYKGQSWARTGVNVDDDFAPIYVVSADKKSTIKQLKAELKNADELYLATDGDREGEAIAWHLLQELKPKIPVKRMVFHEITPAAIQEAVKHPRTLDEDLVEAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLIVDRERDRMAFRAASYWDIEAILDAGASATPRQFPARLVSLDGQRIAQGSSFDSLGHAKSDVAVLDKPATDALSSALATAPFVVTAVEAKPYTRRPAAPFRTTTLQQEAGRKLGFTTDRTMRVAQELYEDGYITYMRTDSVTLSGQAITAARDAITQLYGADYVPERPRIYNSKVKNAQEAHEAIRPSGEHFRTPAQTGLRGDQFKLYELVWQRTVASQMADATGQQMTVRIEATPTQRVALEGVTPQPVRTAQFTASGRTITFQGFLKAYVESSDKPEQAQARLPQLAAEQKLDAAAINPEGHETKPPARFTEPSLVAKLEELDIGRPSTYASIIRTITSRDYVFKRGSALVPTWLAFAVTRLLEEHFSELVDYDFTAALEDHLDEIAKGDADRLAVLQSFYFGNNNADTHEGLHELTNSLGDIDARALSTFHLGDLGSGIDVRVGRYGTYVQDEEEHRANVPEDMAPDELTVEAARELLAHTGGDERELGLDPTTHLAIVVKAGRFGPYVTEVLPDDDDAPAAKKSKVKPRTASLFRTMDPATVTLDDALKLLSLPRVVGGEGEEQVTAQNGRYGPYLKKGSDTRSLPSEESIFTTTMEQAAELFAQPKRRGRQAAAPLRELGEDPNSGKPVVVKDGRFGPYVTDGEYNATLRKADSVEAITLDRAAELLAEKRAKGPAPKKRTTRKATAKKAAAAKKPAAKKPAAKKPAAKKTASTAKPAAKKPAAKKSASTSTN
(1273) DNA topoisomerase 1 [Microlunatus phosphovorus NM-1]
8
MATTTGRRLVIVESPKKATQIASFLGDGYIVQSSRGHIRDLPTGAAEVPAKYKGEKWARTGVNVDHDFEPLYVVAPDKRPTLRSLKDALSNADELLLATDGDREGEAIAWHLLQELKPKVPAKRMVFHEITPHAIAEAVANPRDLDVDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLIVDRERERIAFRSASYWDIDAILDAGAEAEPPLFASRLVTVGEQRVAQGRDFNSRGALQSKGNEQLVHLDEKAATTLAEALRQADFTVRSIESKKITRRPSAPFRTTTMQQEAGRKLGFTAQRAMSVAQSLYENGHITYMRTDSVQLSGTAISAARHQVRQLFGPQYLPEKPRVYSSKVKNAQEAHEAIRPAGEVFRTPAQTGLTGDEFRLYELIWMRTIASQMRDAEGEQVTIKIDARPRPESGQPQCGFTSTGTTITFPGFMKAYVESTDDASSDDESTRRIPQLHEGQSLRPEEITAAGHETRPPARYTEPSLVAKLEELEIGRPSTYASIIRTITSRDYVFKKGSALVPTWLAFAVTRLLEEHFPKLVDYAFTAEMEDVLDEIAGGRAQRLAVLTDFYFGSKAGAADDREGLQRLVSELGDIDARKLSTFPIGDLESDPGAGGIVVRVGRYGTYVEDGEGRRANVADDLPPDELTVELARELLSKPMGEERELGLDPESHHQIVARNGRYGPYVTEVLPEDAPKSQKPRTGSLFRSMTIEGVTLEQALRLMSLPRVVGVDNDGAEITSQNGRYGPYLKKGTDSRSLETEDQIFDITLDEAKAIFAQPKQRGRAAAKPPLKELGNDPVSGKPMVIKDGRFGPYVTDGEFNATLRRGDEIETITPERAAELLAEKRAKGPAPKKRAAAKKAPAKKAATTRTGTAAAAKKTTTARKTSTTAKKATSARKAPAKRAGSTSSS
(924) DNA topoisomerase 1 [Streptomyces cattleya NRRL 8057 = DSM 46488]
8
MSPTTETAQGGRRLVIVESPAKAKTIKGYLGPGYTVEASVGHIRDLPNGAAEVPAKYTGEVRRLGVDVEHDFQPVYVVNADKKTQVKKLKELLAESDELLLATDEDREGEAIAWHLQEVLKPKVPVRRMVFHEITKDAIQAAVRNPRELNKRLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERMAFSSAEYWDLVGTFGTGRAGDPTDPGTLTARLTSVDGRRVAQGRDFGPNGRLKEGSAVLHLDESAARALAAALADTRFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGMGAKATMQVAQKLYENGFITYMRTDSTTLSETAISAARTQVTQLYGADYLPDKPRVYASKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQYHLYELIWMRTVASQMKDAVGQSVTVKVAGRSADGRDAEFSASGKIITFHGFLKAYVEGADDPNAELDDRERRLPQVTEGDPLTAHSLDADGHSTKPPARYTEASLVKELEEREIGRPSTYATIMGTILDRGYVFKKGTALVPSFLSFAVVGLLEKHFGRLVDYDFTARMEDDLDRIARGEAQAVPWLRRFYFGEAAEGQAGVAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGDGIVLRVGRYGPYVEQAVTGEDGEETSRRADVPDDLPPDELTVDYARELLAKPTGAIELGTDPATGHTIVAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLLKSMALDTVTLEDALKLMSLPRVVGTDPESGAEITAQNGRYGPYLKKGTDSRSLDSEEKIFTVTLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSERPVVVKDGRFGPYVTDGETNATLRRDDDVETITPERGYELLAEKRAKGPAKKATAKKAPAKKAPAKKATAAKKTTAAKKTAAKKTTAAKKTTAKKATAKKATSAAAGTAVATDDGE
(923) DNA topoisomerase 1 [Streptomyces cattleya NRRL 8057 = DSM 46488]
8
MSPTTETAQGGRRLVIVESPAKAKTIKGYLGPGYTVEASVGHIRDLPNGAAEVPAKYTGEVRRLGVDVEHDFQPVYVVNADKKTQVKKLKELLAESDELLLATDEDREGEAIAWHLQEVLKPKVPVRRMVFHEITKDAIQAAVRNPRELNKRLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERMAFSSAEYWDLVGTFGTGRAGDPTDPGTLTARLTSVDGRRVAQGRDFGPNGRLKEGSAVLHLDESAARALAAALADTRFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGMGAKATMQVAQKLYENGFITYMRTDSTTLSETAISAARTQVTQLYGADYLPDKPRVYASKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQYHLYELIWMRTVASQMKDAVGQSVTVKVAGRSADGRDAEFSASGKIITFHGFLKAYVEGADDPNAELDDRERRLPQVTEGDPLTAHSLDADGHSTKPPARYTEASLVKELEEREIGRPSTYATIMGTILDRGYVFKKGTALVPSFLSFAVVGLLEKHFGRLVDYDFTARMEDDLDRIARGEAQAVPWLRRFYFGEAAEGQAGVAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGDGIVLRVGRYGPYVEQAVTGEDGEETSRRADVPDDLPPDELTVDYARELLAKPTGAIELGTDPATGHTIVAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLLKSMALDTVTLEDALKLMSLPRVVGTDPESGAEITAQNGRYGPYLKKGTDSRSLDSEEKIFTVTLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSERPVVVKDGRFGPYVTDGETNATLRRDDDVETITPERGYELLAEKRAKGPAKKATAKKAPAKKAPAKKATAAKKTTAAKKTAAKKTTAAKKTTAKKATAKKATSAAAGTAVATDDGE
(832) DNA topoisomerase 1 [Nocardioides sp. JS614]
8
MAHKLVIVESPAKARTIGGYLGQGYVVESSIGHIRDLPQSAADTPAKIKDKPWGRLAVDVDNGFEPYYVVPRDKKSHIAKLKTLLKEADELYLATDEDREGEAIAWHLLDELKPKDIPVKRMVFHEITKPAIIAAAEHPRELDMDLVEAQEARRILDRLYGYEVSPVLWKKVMSGLSAGRVQSVATRLVVDRERERMAFRVASYWDLEGTFDAGATKEPRMFPAKVHSVDGSRVAGGSDFGPDGLLKAKKGERVHLDRAAAEALVAALAETTYDVRSVEAKPYRRSPYAPFRTTTLQQEASRKLGMSASVTMSVAQRLYENGFITYMRTDSTTLSGGAVEAARAQVRELYGAEYLPDTPRTYTSKVKNAQEAHEAIRPAGDSFRTPAQTGLTGDQFRLYELIWMRTVASQMKDATGQSVSVRIGGVAADGRDVVFAASGRVITFHGFLKAYVEGTEGGKRSDDDQVPLPDLHEGDAVSAASLAANGHETKPPARYTEATLIKELEDREIGRPSTYASIIGTILNRGYVYKKGTALVPAWLAFSVTRLLEEHFPRQVSYEFTAGMEDVLDEIAGGRKDLKSELSEFYYGSDSVVGLKPLVDGLGEIDARELATFPIGGADAGINLRVGRYGPYLEGPDDDGTAYARRANVPDDLPPDELTLDKAKELLANPAGEEIRLGVHPDTGLEVVAKNGRFGPYVTEVLPEDAAQGRKKGAAKPRTGSLFKSMSLDTVTLADAVKLLSLPRVVGVAEDGEEVTAQNGRYGPYLKKGTDSRSLASEDQLLTITLDEALRIYAQPKQRGRAAAAAPLKELGNDPVSGQPVVVKAGRFGEYVTDGEYNATLRKEDSVESITIERAAELLAERRAKGPAKKAAKRGAKKAPAKKAAAKKTATKKAATKKATAKKAT
(114) DNA topoisomerase 1 [Streptomyces scabiei 87.22]
8
MSPTSETAKGGRRLVIVESPAKAKTIKGYLGPGYIVEASVGHIRDLPNGAAEVPEQYTGEVRRLGVDVEHDFAPVYVVNADKKAQVRKLKDLLKESDELFLATDEDREGEAIAWHLQEVLKPKVPVKRMVFHEITKAAIQAAVANPRELNQRLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDASDPASLVARLQSVDGRRVAQGRDFDSVGQLKGANVLHLDEANARALAAALENTRFSVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSETAVAAARAQVTQLYGADYLPAQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKRTVASQMKDATGNSVTVKIGGTASDGRDAEFSASGKTITFHGFLKAYVEGADDPNAELDDRERRLPQVGEGDALSAEQITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTAKMEDDLDRIARGEAQAVPWLKRFYFGEGTGSGGTAAEAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGDGIVLRVGRYGPYIERGEKDAEGHQRADVPEDMAPDELSVELAEELLAKPSGDFELGADPATGHQIIARDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLADALKLMSLPRVVGADAEGQEITAQNGRYGPYLKKGTDSRSLQTEDQLFTITLEEALAIYAQPKQRGRAAAKPPLKELGEDPVSAKPVVVKDGRFGPYVTDGETNATLRSGDSVEEITPERGYELLAEKRAKGPAKKTAKKAPAKKTATKTAAKKAAPAKKTAAAKTAASKTAAAKKAAPAKKAAAKKATSAGESA
(1304) DNA topoisomerase 1 [Streptomyces venezuelae ATCC 10712]
8
MYRHTPQRRERHRPCRCRACQRRTCPESVEPERRAKLSPTSEAAHGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPSGAAEVPEKYTGEVRRLGVDVEHDFQPIYVVNADKKAQVRKLKELLAESDELFLATDEDREGEAIAWHLQEVLKPKVPVHRMVFHEITKDAIREAVANPRELNQRMVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFGTGRSGDASDPSQLVARLAAVDGKRVAQGRDFGADGRLKSESVLHLDEANARALAAALADTAFSVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTILSDTAVSAARAQVTQLYGADYLPEKPRVYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIWKRTVASQMKDATGNSVTVKIGGRAADGRDAEFSASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVAEGDALTADEITADGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTAKMEDDLDRIARGEAQAVPWLKRFYFGDAGGGTAAAGGAADAGNGDGDHLGGLKELVTDLGAIDAREISSFPVGNDIVLRVGRYGPYVERGEKDAEGHQRADVPEDLAPDELTVELAEELLAKPSGDFELGADPVSGNQIVAKDGRYGPYVTEILPEGTPKTGKNAVKPRTASLFKSMSLDTVTLEDALRLMSLPRVVGADAEGVEITAQNGRYGPYLKKGTDSRSLTEEEQLFTITLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSEKPVVVKDGRFGPYVTDGETNATLRTGDSVEDITPERGYELLAEKRAKGPAKKAAKKAPAKKTTTAKKTATKTAAKKTTAAKKTAVKKTTTAKKTTAAKKTAAAKPE
(949) DNA topoisomerase 1 [Acidimicrobium ferrooxidans DSM 10331]
8
MPKPLVIVESPTKARTIRRYLGDEWVVEASVGHVRDLPRSAKEIPQAVKKEPWARLGVDTEHGFRPLYVIPPEKREQVKRLKALLADASELFLATDEDREGESIAWHLLEVLAPRVPVRRMVFHEITERAIREAVGATRGIDRGLVDAQETRRVLDRLFGYEVSPVLWKKVMPRLSAGRVQSVACRLLVERERERMAFRRASYFDVVAEFSRAEAPAPFAARLVALDEARIATGRDFDATGRVATGVVVLDGAHALAVAEAVEGRGGVVRELTERPFTRRPDAPFMTSTLQQEASRKLRFSAQRTMAVAQRLYEQGFITYMRTDSVQLAGEALAEARRLIAERFPGALPDAPRQYRSRVKNAQEAHEAIRPAGTRWRSPDEVAREAPGDEARLYELIWRRTLASQMTDARGMSAVATIDVALGPEVRIDGREIERATFVARGRTLTDPGFLAVYPEQLSEDDEVDLPPLAAGVALTTTGAQPQGHETQPPARYTEASLVRALEERGIGRPSTYAQIISTLVERSYAWRRSQALIPTFLGFAVVQLLERHFAELVDYSFTARLEDDLDRIAIGEEEPTPYLAHFYWGNGAPGLHQLVTERLGEIDARDVNSIPIGQRADGTPVVVRVGRYGPFLQAGEETASIPEDLPPDELTLERAEELLERGRLGDRVLGELDGQPVLLRTGRFGPYVQLGEGDDRSLRRASLLPGQRVETLSYEDAVALLSLPRLVGVDPESQQEIWAHNGRFGPYLAKGRDTRSLDKPEQLFTIDLTEALARFREPKRRGRSASVLELGTHPDTGARVVVRSGRYGPYVSDGEVNASLPRGVDPASLDLDTAVELLAERRARLGSGS
(1797) DNA topoisomerase type IA central domain protein [Eggerthella lenta DSM 2243]
3
MKLVVTEKNDAAQKIADLLGVKKPKADKVYSTPVYRFDVDGEEWVTIGLRGHILEPDFAPTMVYKKRGGWQGVTEEGETLPAELPASLPKPPFKKKKPFTEDGVELKSWKMDALPYLVYAPINKLPKEKEIIRSLKNLAKKADSVIIATDFDREGELIGSDALSCIQEVNPTAPVSRARYSAFTKEEITHAFDNLVELDVNLASAGASRQDIDLIWGAVLTRYLTLVKFAGYGNVRSSGRVQTPTLALVVARERERLAFVPEDYWVIRGAFGADPDSFEAPHATARFKAEAEAQAVMAHVEGATRATVASVEKKKRTVQPPAPFNTTSLMAAASAEGLSPARTMRIAESLYMDGYISYPRVDNTVYPSSLDLADTVKAISGNPAYAPYCKELLAKGKLTATRGKKETTDHPPIYPTAKATPDDLAPADYKLYNLIARRFLATLSEAAVIEGTKVTLDVNAEPFVAKGDVLVKPGYRAIYPYGLKKDEQLPALSEGETVAFNGAVCTKKQTEPPARYSQGKLIQEMEKLGLGTKSTRHAIIERLYAVKYCMNDPIEPSQLGMAVCDALDKFAPHITHPEMTAELEEEMDNIAEGRTTKAQVVDTSRNLLSEQLASLLPHSEEVKEALADAVAADAYVGPCPKCGKDLQLRASQKTRSMFIGCAGWPDCDVTYPLPKGKVEAVPEPCPTCGMPQVKVTAFRSKPRTICIDPHCSTNQEPDVVVGECPACKEKGIQAKLIAQKNPRTLKRFIRCENYDDCGTGYPLPQYGALTATEEVCEHCGAPMVIVTTARGPWKLCPNFDCPGKEQKEDEKGAKGAKGTAAKKPAAKAPAKKPAAKKAPAKRAPAAKKD
(327) DNA topoisomerase [Eggerthella lenta DSM 2243]
7
MPTLIIAEKPSVARGIADAVGAHERRDGYIEGGGYLISWCRGHIIDLDFPQNYPQWSGHWSMSQLPMIPERWRWSVTAPEQYKVLKGLLDRADVELVVNACDADREGEGIFRRVWTHSGCKKPVRRFWSTSLVPEQVRTDLAHAKPLSDYDGLADAAEGRAKADWLVGLNASRALSCLYEGSRLSAGRVQTPTLALVVERTRAIRGFKSVPFFQVECSVGRTAHVRLAGEKLKTRQEALRRAHAAVGSQCAILKVERRQEKCRAPKLYDLTGLQRDASTRAGLTAEETLNALQTLYEKKLATYPRTESRYIGESDIPETARVLSAIAVPGIVGEAAAAGFDASRSDVARVADDSKVHGHGAILPTALLDAKEMAKLDGAERSVAILICCRLMAATMDPATKLKTKVEGEVNGDAYTASGSTVTDASWIAVDEACRAALAGGGKAAEDEDDEAQDIPADIEQGDSFTVADGDVRVKDGKTTPPKPYTDATLLSAMEHAGRSIEDRELKAAIEDDSMHSGGLGTPATRARMIEKLIEAKYIRRRGKTLSATERGETLIDIVCDSLKTPELTAKWELALSHVERGEGSLSDFLSGIEGYTAAVVSDLERGFDPAQAAAVSGREELCRCPACGAPIVLSRSGRQWQCSSSKWAGKEEGWRLLQGCGVKLNIVQNGRKLTKSQAKSILSGGTVHLTGLSKKAGSGTFDTDAKLGAAPYTGFVEFCRSEKPGGSAGRTGSRRRGGKR
(944) DNA topoisomerase type IA central domain protein [Atopobium parvulum DSM 20469]
3
MILVVTEKNDAAQQIARLLSESGKPEADKVYNTPVYRFRRGGEDYVAIGLRGHILQPDFPLALKFDKEEGWYGETAEGEHLPADVPDGLERPPYKVKRKPFMADGVDLKGWKIPSLPYLIWAPVDKQPAEKEIIRALKNLAKKAESVIIGTDFDREGELIGSDALAQVLSVNPNLAVFRARYSAFTKTEIETAFNNLVDLDYNLAAAGESRQYIDLIWGAVLTRYLTTARFGGLGNTRSAGRVQTPTLALVVERERERLAFKPEDYWVISGVASPEDDDEATFKMVHQTARFWDQAEADTVYDVVKDQTQATVVEIESRSRKQQPPAPFNTTSLQAAAAAEGISPARTMRLAESLYMDGLISYPRVDNTVYPSSLDLKDCVRTLSAVPQYAPTCKKLLGQPKLHATRGKQESTDHPPIYPTAAANPDSLQPAAWKLYNLIARRFLATLMGPATMSGTKITLDVAGQPFVANGTVLAEPGFREIYPFGLKKDDQIPDVGEGEIVSIKSLSLDAKQTEPPARYSQGKLIQEMEKRGLGTKSTRASIIDTLYQRKYLKNDPVEPSQLGMAIVDALSQFAPHITSPDMTAELESDMTSVAEGKDTRDGVVTHSRSLLAGMIDVLIDHKEDLSEAIADAVTADAKVGTCPKCGKDLVAKSSLKTRGSFVGCMGWPDCDVTYPLPQGRVEPLEGEAGVCPECGAPRVKVQPFRQRAYETCINPACPTNSEPDLIVGECPTCKANGKHGDLVAHKSERTGKRFIRCTNYEECETSYPLPARGKLEKTDEVCPDCGAPMVVVTTQRGPWKLCPNYDCPGKEKKTAPRRGARKSTKSTKSTKAAKK
(790) DNA topoisomerase 1 [Streptomyces sp. SirexAA-E]
8
MSPTSETAQGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPDEYTGEVRRLGVDVEHDFQPVYVVNADKKAQVRKLKQLLAESDELFLATDEDREGEAIAWHLQEVLKPKVPVHRMVFHEITKDAIRAAVANPRELNQRMVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRGGDASDPSTFTARLSAVDGRRIAQGRDFGPDGLLKAASGQTLHLDEENARALAAALADSAFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSDTAVSAARAQVTQLYGSDYLPDKPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIWKRTVASQMKDAVGNSVTVKIAGRASDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVTEGDALTADEVTVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLRRFYFGAGADTDGAGAASDAGNGDGDHLGGLKELVTDLGAIDAREISSFPVGNDIMLRVGKYGPYIERGEKGAENHQRADVPEDLAPDELSVEYAEELLAKPSGDFELGTDPVTGHQIIAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLADALKLMSLPRVVGEDAEGVEITAQNGRYGPYLKKGTDSRSLTSEDQLFDITLDEALAIYAQPKQRGRAAAKPPLKELGTDPVSGAPVVVKDGRFGAYVTDGETNATLRTGDSVEEITPERGYELLAEKRAKGPAKKKTAKKAPAKKATAKKAATAKKTAAKKTTAAKKTTAAKKTTTAKKAATAKKAPAKKATASSTTED
(813) DNA topoisomerase 1 [Streptomyces coelicolor A3(2)]
8
MSPTSETAKGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPSGAAEVPEKYTGEVRRLGVDVEHDFQPIYVVNADKKSQVKKLKDLLKESDELFLATDEDREGEAIAWHLQEVLKPKIPVKRMVFHEITKDAIRAAVANPRELNQKLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDASDPSSLVARLQTVDGRRVAQGRDFDSLGQLKSANTLHLDEANARALAAALENTRFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKSTMQVAQKLYENGYITYMRTDSTTLSDTAVSAARAQVTQLYGADYLPPQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKRTVASQMKDATGNSVTVKIGGAASDGRDVEFSASGKTITFHGFLKAYVEGADDPNAELDDRERRLPQVAEGDALTAEEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLRRFYFGEGDGTGGGGAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGNDIKLRVGRYGPYVERGEKDAENHQRADVPEDLAPDELSVELAEELLAKPSGDFELGTDPATGHAIVAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLDDALKLMSLPRVVGADAEGVEITAQNGRYGPYLKKGTDSRSLQTEDQLFEITLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSEKPVVVKDGRFGPYVTDGETNATLRSDDSVEEITPERGYELLAEKRAKGPAKKTAKKAVKKTAAKKAPAKKAAATKKTAAAKTTAAKKTAAKSTAKKTTAKTAAKKATASKTSED
(877) DNA topoisomerase 1 [Streptomyces bingchenggensis BCW-1]
8
MSPTSETAQGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPDQYTGEVRRLGVDVEHDFQPVYVVNADKKSQVRKLKELLADSDELFLATDEDREGEAIAWHLQQVLKPKVPVRRMVFHEITKDAIRAAVANPRELNQRLVDAQETRRILDRLYGYEVSPVLWKKVMRGLSAGRVQSVATRLVVERERDRIAFRSAEYWDLTGVFATGRAGDTSDPGTFGARLTAVDGRRVAQGRDFTSTGQLKGAQVLHLDEAGARGLATALADTAFTVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSETAVAAARAQVTQLYGADFLPDKPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIWKRTVASQMKDAVGNSVTVKIGGRASDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVAEGDRLAAQEITADGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTAKMEDDLDRIARGEAQAVPWLKRFYFGESATEPGAESGAAPGAVGGAADAGNGDGDHLGGLKDLVTDLGAIDAREISSFPVGDGIVLRVGRYGPYVERATEAEGATGQRADVPDDLPPDELTVEYAEELLAKPSGDFELGTDPATGRKIVAKDGRYGPYVTEVLPEDTPKTGKNAVKPRTASLFKSMSPDTVTLEDALRLMSLPRVVGTDAEGVEITAQNGRYGPYLKKGTDSRSLESEEQLFTITLDQALAIYAQPKQRGRAAAKPPLKELGTDPVSERPVVVKDGRFGPYVTDGETNATLRRDDDVETITPERGYELLAEKRAKGPAKKTAKKAAAKKTTTAKTTAAKKTTTAKKTAAKKTTAAKKTAAKKTATAAKAAPKPAAKAD
(1676) DNA topoisomerase 1 [Streptomyces violaceusniger Tu 4113]
8
MSPTTSETAQGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPDKYTGEVRRLGVDVEHDFQPVYVVNADKKSQVKKLKELLADSDELFLATDEDREGEAIAWHLQEVLKPKVPVRRMVFHEITKDAIRAAVANPRELNQRLVDAQETRRILDRLYGYEVSPVLWKKVMRGLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDVSDPGTFGARLTAVDGLRVAQGRDFTSLGQLKDGVNVLHLDEAGARSLATALADTAFTVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGYITYMRTDSTVLSDTAVTAARAQVTQLYGADYLPDKPRTYAGKVKNAQEAHEAIRPSGERFRTPAETGLSGDQFRLYELIWKRTVASQMKDAIGNSVTVKIAGQASDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVTEGDRLSAEEITADGHATKPPARYTEASLVKELEEREIGRPSTYATILGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTAKMEDDLDRIARGEAEAVPWLKRFYFGEGAQAGAAEAGNGDGDHLGGLKELVTDLGAIDAREISSFPVGDGIVLRVGRYGPYVERPTEIEGGTGRRADVPDDMPPDELTVAYAEELLAKPSGEFELGPDPDTGRMIVAKDGRYGPYVTEVLPEDTPKSGKNAVKPRTASLLKSMSLDTVTLEDALKLMSLPRVVGADPEGVEITAQNGRYGPYLKKGTDSRSLESEEQLFTITLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSERPVVVKDGRFGPYVTDGETNATLRRDDDVETITPERGFELLAEKRAKGPAKKTAKKTAAKKTAAKKATATKTAAKKTAAKKTTAKKTTAKTAAKKTAAAKKSSADAE
(752) DNA topoisomerase 1 [Streptomyces pratensis ATCC 33331]
8
MSPTSETAGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPDEYTGEVRRLGVDVENDFQPIYVVNADKKAQVRKLKQLLAESDELFLATDEDREGEAIAWHLQEVLRPKVPVHRMVFHEITKDAIRAAVANPRELNQRMVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRTGDASDPSTLTARLSAVDGRRIAQGRDFGPDGQLKQGSAQTLHLDETNARALAAALADSTFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSDTAVSAARAQVTQLYGANYLPDKPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIWKRTVASQMKDATGNSVTVKIGGRASDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVAEGDALTADEVTVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLRRFYFGADDDTAGAGKASDAGNGDGDHLGGLKELVTDLGAIDAREISSFPVGNDIKLRVGRYGPYIERGEKDSEGHQRADVPEDLAPDELSVELAEELLAKPSGDFELGADPVSGNQIIAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLADALKLMSLPRVVGEDAEGVEITAQNGRYGPYLKKGTDSRSLTSEEQLFDITLDEALAIYAQPKQRGRAAAKPPLKELGTDPVSGAPVVVKDGRFGAYVTDGETNATLRTDDSVEAITPERGYELLAEKRAKGPAKKKTAKKAPAKKATAKKATTAKKATAKKTAATKTTAAKKTTTAKKAPAKKATAAAKKTATASSDEG
(1644) DNA topoisomerase 1 [Frankia sp. CcI3]
8
MPARTKTTTRATARSSAPVAEPTEAGLPPETGSSEASADVPAGATSRTANGRTEAGHSANGSGGATGAHGSRATGSGPGNRLVIVESPAKAKTIAGYLGPGWQVESSIGHIRDLPRSAADVPAAHKGKPWARLGVDVDNDFEPLYIVTPDKKPQVSKLKALVKDASELYLATDEDREGEAIAWHLLQTLKPTVPVKRMVFHEITPQAIQRAVDNPRDIDKNLVNAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRILVERERARMRFHSAEYWNIEGLFGATVARQAWSGADGTPGSGPDGPGAGSIRGDGVEKTPLPATLIALNGNRIATGRDFSPTGQLVSSGVTRLDEATARSLAERLADAAFTVRSVETKPYRRSPYPPFMTSTLQQEAGRKLRFSSQRTMQVAQRLYENGYITYMRTDSTNLSKTALTAARAQAASLYGPEYVPARPRTYAKKVKNAQEAHEAIRPAGDHFRTPGEVRGELDVDSYRLYELIWQRTVASQMADARGTSATIRLGATSSAGEDAEFSASGKVITFPGFLRAYVEGADDPDAELEDRERRLPDVRQGDPLTTRSLTPRGHTTSPPARFTEASLVKTLEELGIGRPSTYASIIGTIQDRGYVWKKGSALVPSFVAFAVVGLLEDHFTRLVDYRFTATMEDDLDDIAAGTAASTDWLTRFYFGTGDGTDPAADGLKHLVNERLGEIDAREVNSIPLGETDDGTLLVVRVGRYGPYVQHGERRASVPDDLAPDELTVDKALGLLAAPSGDRMLGIDPASGATITAKAGRFGPYVTTDTDPPRTSSLLRGMSLETLTLDDAVRLLTLPRILGAGDDGEEVTAQNGRYGPYVKKGAESRSLESEDQLFTVTLDEALALLSQPKARGRRQAAQSPPLRELGTDPASGKPMVVREGRFGPYVTDGETNASLRKGDTVETITDERAAELLADRRARGPATAKRPARGTAKAGTAKTGPKTTKAKPDTAKSGTAKSGTAKTGTAKTGTAKTGTARSKTARTVTDDGGGSDGSDDSGSSSSSGTRRTD
(232) DNA topoisomerase 1 [Frankia symbiont of Datisca glomerata]
8
MPPRTKSTNSGTRRSSAGSSTPVVEPTAGDVAAGPDTDAVTAGNGAVSRGRTTRTARAATRGSRTGTSSPAASGTGVRLVIVESPAKAKTIAGYLGSGWRVESSIGHIRDLPQSAADVPDAHKGKPWARLGVDVDNGFKPLYVVTPDKKSQVSKLKALAKEASELYLATDEDREGEAIAWHLLQTLKPTVPVRRMVFHEITEQAIRRAVDNTREIDEHLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRILVERERARMRFTSAEYWNIEGVFGLLPGRDADRAGGASGDGQVDATPLPANLVALDGRRLATGRDFDSSGQLTSADVVRLDEDAAHALAGRLADSAFAVRSVETKPYRRSPYAPFMTSTLQQEASRKLHFSSQRTMQVAQKLYENGYITYMRTDSTNLSETALAAAREQARALYGAEYVPDRPRIYTKKVKNAQEAHEAIRPAGEQFRTPGEVRETLADADGYRLYELIWRRTVASQMADARGTSATIRIGGVSSAGEDTEFSASGKVITFPGFLRAYVEGADDPDAELDDRERRLPDVREGDALTTRELNPRGHTTNPPPRFTEASLVKTLEELGIGRPSTYASIIGTIQARGYVWKKGSALIPSFVAFAVVGLLEEHFGRLVDYRFTASMEDDLDDIAAGTAASIDWLTRFYFGSDAGQEGGVARAGGLKHLVNERLGEIDAREVNSIPLGVAPDDQPVVIRVGRYGPYVQHGDERASVPEDLPPDELTVDRALALVGAPSEERSLGTDPDSGATITLKVGRFGPYVSTDDDPPRRASLLGTMTPETLTLADALKLLTLPRSLGVAEDGEEVTAQNGRYGPYVKKGSESRSLESEERLFTVTLDEALALIAQPKTRGRRRAAETPPLRELGPDPATGAPMVLREGRFGPYVTDGATNASLRKGDDVASLTVERAAEMLAEKRARGPATPRRRAAQPAKQPAATKTTRQSTAKKTTARKTSAQPATATGTGTGTTTGTDGGGTPGTSSPRPRRTG
(1872) DNA topoisomerase 1 [Pseudonocardia dioxanivorans CB1190]
8
MATRTTRSKAGADDGSAPAAAGSRRNGTPTATTTGRPTRRLVIVESPTKAKKIAPYLGKDYVVESSVGHIRDLPRGAADVPAKYKGESWARLGVDVDNEFQPLYIVTPEKKGKVSELRDALKSVDELLLATDPDREGEAIAWHLLDTLKPKVPVRRMVFHEITEPAIRAAAENLRDLDQDLVDAQETRRILDRLYGYEVSPVLWRKVMPKLSAGRVQSVATRLIVQRERERMAFVSASYWDIAATLDAGAEASPRTFGARLVAVDGNRVATGRDFGADGQLKSDAVALDEAGARRLAEALDGVDLTVSSVESKPYTRKPYAPFMTSTLQQEAGRKLRFSAERTMRTAQRLYENGYITYMRTDSTTLSESAINAARTQARELYGDSYVSPQPRQYTRKVKNAQEAHEAIRPAGETFRTPGEVAREVDGDDFRLYELIWQRTVASQMADARGTTMSVRIVGTAATGEEATFAASGRTITFPGFLKAYVETVEEGTDGQADDAESRLPNLAEGAAVTATELNPDGHSTNPPARYTEPSLVKQLEELGIGRPSTYASIIKTIQDRGYVWKKGSALVPSWVAFSVIGLLEHHFGRLVDYDFTAAMEDELDAIASGNYSRTDWLTSFYFGADEGTEGSVARAGGLKKLVGVNLEEIDAREVNSIPMFTDAEGRDVVVRVGRYGPYLERLVEGASQRANLPDDLPPDELTAEIAEKLFSVPQEGRSLGTDPVTGHEIVAKEGRFGPYVTEILPEPEAPAEGTTTRKKAPAKPKPRTGSLLKSMTVESVTLDDALRLLSLPRLVGTDPESGEEITAQNGRYGPYLKKGTDSRSLTDEEQMFTVTLDEALEIYKQPKQRGRRTAAATPPLRELGEDSATGKKMVIKDGRFGPYVTDGETNASLRKGDSVEEITDERASELLADRRSKAPVKKAPARRKTAAASKTTTTKKAAARRTTPVES
(193) DNA topoisomerase 1 [Bifidobacterium dentium Bd1]
8
MATGSKLVIVESPTKARKIGGYLGSDYTVMASVGHIRDLAQPSQVPSADKAKFGKFGVDVEDGFKPYYIVDGDKKKTVSELKSALKKADTLYLATDEDREGEAIAWHLVQTLKPKVSIKRMVFHEITPEAIKASLNNTRDVDGAMVDAQETRRILDRLYGYELSPVLWRKVGPGLSAGRVQSVATRLIVERERERMAFVRAPYWDVTATLEAMGAEGDNVAFDSRMVSLDGRRLAGSKDFGEDGLLTAAGAKDNVVQLDETQARALAQSLEFATFTVTSMESKPYRRRPLPPFTTSTLQQTAGNRLSMSSRQTMRAAQGLYENGYITYMRTDSVTLSQEAIAAARSAVKSHFGDTFLSDAPKQYATKTAGAQEAHECIRPAGAQFRDPDEVAKKVPADQARLYALIWQRTLASQMADATGSTATVRLSASAGDQGEAVFQASGTVIEFPGFMKATGEGRHASSDRATDKTAEQSVKANDDNASLPPMRPGDELAATEVAADGHETQPPARYTEASLVKTLEAKEIGRPSTYASIISTIIDRGYVYERGRALIPSWLAFSVVKLLETKFPKYVDYQFTADMENGLDQIAHGMETGKDWLTSFYFGSGEGAAQSQDEAHAGLQQQVAQLGEIDARAINTIEIGDGLHVRVGRYGPYLEDVNDLDGEGNPKRASLPDTLAPDELTVEVGHDLIEHHSGGPRELGKDPVSGGTVEVRNGRFGPYVALIVPQSEAAGDAAAAQAKPQRGSKKAAADRPKMASLFKTMSPESLTLEDALKLLSLPREVGTYEEANAETGELQQVTVMANNGRYGPYLTKTGADGKSDTRSLASEDEIFTVDLDKAKELFSQPKYGRGRGRGAAKPPLRDLGVDPETQKHVTIKEGFYGAYITDGETNRTLPKQYAAESIEPAEAFRLLAEKRAQGPSKRGRGRKASAKKTTAKSTKAGKPNAIEKARADRRAKVRELADQGWANTRIAKEIGSTAATVKADIDWLTANEGYFRPEVVPAR
(1715) DNA topoisomerase 1 [Bifidobacterium adolescentis ATCC 15703]
8
MAMATGSKLVIVESPTKAKKIGGYLGSGYTVMASVGHIRDLAQPSQVPAAEKAKYGKFGVDIEDGFKPYYIVDGNKKKTVADLKSALKKADTLYLATDEDREGEAIAWHLVQTLKPKVPVKRMVFHEITPEAIKASLNNTRDVDAAMVDAQETRRILDRLYGYELSPVLWRKVGPGLSAGRVQSVATRLIVERERERMAFVRAPYWDVTATLEAPDADGNNVAFDSRMVSLGGRRLAGSKDFGDDGQLTAAGVKDNVVQLDETHANAIARSLEYATFTVSSMETKPYRRRPVPPFTTSTLQQTAGNRLGMSSRQTMRAAQGLYENGFITYMRTDSVTLSQEAIAAAREAVSRHFGEKYLSDAPKQYATKTAGAQEAHECIRPAGAHFRDPAEIATKVPADQLKLYTLIWQRTLACQMADATGSTATVRLSSPTEADGEAMFQASGTVIEFPGFMKATGEGRRSVVDAKKSAEAAGVKIGDKAEKSAKASKKTDDNVSLPPMQPGDELAAVDVAADGHETQPPARYTEASLVKTLEQKEIGRPSTYASIISTIIDRGYVYERGRALIPSWLAFSVTKLLETKFPKYVDYEFTADMETGLDQIAGGHETGKAWLTRFYFGSGDGAAQSADEAHEGLQQQVAQLGEIDAREINTIDIGDGLHVRVGRYGPYLEDMKHLDAEGNPKRASLPDTLAPDELTVEVGHDLIENHSGGPRELGKDPVSGGTVEVRNGRFGPYVALVMPSAEDAGDTAAESAAGKAGKTKRSGGKKAASDRPKMASLFKTMSPESLTLEDALKLLSLPREVGSYDEANAETGEMQTVTVMANNGRYGPYLTKTGADGKSDTRSLASEDEIFTVDLEKAKELFAQPKYGRGRGRGAAKPPLRDLGTDPETQKHVTIKDGFYGAYITDGETNRTLPKQYAPESIEPAEAFRLLAEKRAQGPSKRRGRKTAAKGAKKGAAKGAKSAKKVSATEQARADRRAKVRELADKGWANTRIAKEIGSTASTVKADVDWLTANEGYARPEVVPAR
(1038) DNA topoisomerase 1 [Bifidobacterium bifidum PRL2010]
8
MGTGNKLVIVESPTKAKKIGGYLGSGYTVMASVGHIRDLAQPSQIPADDKARFGKFGVDVDDGFKPYYIVDGDKKKTVAELKKALKNSDELYLATDEDREGEAIAWHLVQTLKPKVPVKRMVFHEITKDAIKASLGNTRNVDEDMVDAQETRRILDRLYGYELSPVLWRKVGPGLSAGRVQSVATRLIVERERERMAFVRASYWDVTAVLGATDAEGEPASFESRMVSLGGKRLAGSKDFSDDGKLAPSGFADNVCQLDEAHANALAKLLADATFTVASMETKPYRRRPFPPFTTSTLQQTAGNRLSMSSRQTMRAAQGLYENGYITYMRTDSVTLSQEAIAAARDAVEYHFGKSFLSDGPKQYVTKTASAQEAHECIRPAGARFHDPAELSGKVPADQLKLYTLIWQRTLASQMADATGSTATVRLSAPAGEDGEAMFQASGTVIEFPGFMKATGEGRRAAAPAASSMGAGDGEVAAKRASRETDDNGSLPPMQTGDRLAASSVEADGHETQPPARYTEASLVKTLEAKEIGRPSTYASIISTIIDRGYVYERGRALIPSWLAFSVIKLLETKFPKYVDYQFTADMENGLDQIAHGQETGRDWLTHFYFGSGGDVATSADEAHAGLQQQVAQLGEIDARAINTIDIGDGLHVRVGRYGPYLEDMNHVDAAGNPKRASLPDTMAPDELTVQVGHELIDSNAGGPRELGVDPASGGTVEVRNGRFGPYVALVPLETDGGSSETKSKKTTVPKPKMASLFKTMSPESITLDDALKLLSLPRTVGVYEEANTETGELGEVTVEANNGRYGPYLTKTGADGKSETRSLASEDEIFTVDVDKAKELFAQPKYGRGRGRGTAKPPLRELGPDPETGKNVTIKDGFYGAYITDGETNRTVPKQYTAESIEPAEAFRLLAEKRAAGPSKRGRRKTTGATAKKTAAKKSSTASATKKTAAAKKTAAKKTTARKTAAKKTVE
(290) Topoisomerase III [Bifidobacterium longum subsp. longum KACC 91563]
7
MKLVIAEKKSVATAIAQALCAAPVQRDGCYECGQLLVTWAQGHLIDLAMPEDYKDRDWRKWSLDTLPVDPSGHWQWKISAERGAGSRYRQIVQLIRRADVDCLVNACDPDREGEAIFRRIADMEGSHKPELRLWVASLEAEAIQAAWRAMKPESEYQGLAWSAEIRSKADWLIGMNASRAYSLLYNARFSVGRVQTPTLAMIAERDRQIRNHKPVPFWTVIADMGGWRLSSERIDSKDAAMLLCGQAEHGRFRIMSVNRRRVNDRPPRLYDLTGLQKDMSRLHGMTAARTLQALQHLYELKLATYPRTDSRYITHDDLETLTALLESGRLAQGFVTREGIPGHPRPELAVNDAKVAGHTAILPTMQLDAGKLEGLDDDERKVMTRIVRRMWEAVGDDHVHIVTEVKARLSDDTDREFSSRSDETVSAGWKAVETGHGPEPEDEETANPAGGRNVIPSNLMEGGVIRPVGKVTVEEGETRPPKPFTEATLLAAMEHASRCVEDKNLKAALDDDESHSGGIGTPATRADTIEKLVRSKLVERKGRQLHATTEGERLTDVVEPRLKDVLLTARMEQALSDVEHGKRDPADVMDMFHREALRIPADATANLKADAVTRTTNTDAQEWGDCPRCGQPVRKTGRMWQCSTNKSEKTKDGKWIAVEGCGWKMYASLAGKTITDQTARRLLAGQTVTLKGFTSKSGKKFDAAIRIDKERGTAFDFDR
(1813) DNA topoisomerase 1 [Bifidobacterium longum subsp. longum KACC 91563]
8
MATKLVIVESPTKAHKIGDYLGKGYTVMASVGHIRDLAQPSQVPAADKAKFGKFGVDVNDGFKPYYIVDGDKKRTVSELKSALKNADELYLATDEDREGEAIAWHLVQTLKPEVPVKRMVFHEITKNAINASLNNTRDVDGNMVDAQETRRILDRLYGYELSPVLWRKVGPGLSAGRVQSVATRLIVERERERMAFKRAPYWDIVATLSAPDALGERAEFSARMIALGGKRLAGSKDFGADGQLTPDGFAANVRQLDEAGATAVASALKTADFTVMSMETKPYRRRPQPPFTTSTLQQTAGNRLGMGARAVMRAAQSLYENGYITYMRTDSVTLSQEGITAARNAVSYHFGDKFLSAEPKQYATKTAGAQEAHECIRPAGSRFHDPDELASKLPGDQLRLYTLIWQRTLACQMADATGSTATVRLSAPAGPTEGEAVFQASGTVIEFPGFMKATGEGRKPKAAAPGAGAGSDQAAAAGKTDAKAVRGDASESNTSLPPMSVGQQVEASDIEPDGHETQPPARYTEATLVKTLEAKEIGRPSTYASIISTIMDRGYVYERGRALIPSWLAFSVTKLLETNFPKLVDYQFTAEMENGLDRIAHGEESGRDWLTHFYFGSGEGAARNADEAHEGLQQQVAQLGEIDARAINTIDIGDGLHVRVGRYGPYLEDMEHLDAEGNPKRASLPDTIAPDELTVAVARDLIDNHSGGPRELGVDPVSGGTVEVRNGRFGPYVALVPPAEASAGAAGDTAGASAAKKGSKKAAAAAASRPKMASLFKTMSPESLSLEDALKLLSLPREVGTYEETNAETGEVSECTVAANNGRYGPYLTKTGADGKSETRSLASEDEIFTVDIDKAKELFSQPKYGRGRGRGAAKPPLRDLGKDPNTGKNVTIKDGRFGAYITDGETNRTVPRQYTPESITPDDAFRLLAEKRAAGPSTRGRRGAGRAGGAKAVAGKGKKGGTSAAVSAQEAKRAERRAEVKKLANKGWSNQRIAEKLGSTPATVKKDVDWLTANEGYERPAVIPKRG
(282) DNA topoisomerase 1 [Bifidobacterium animalis subsp. lactis CNCM I-2494]
8
MDSSGKVRRAIMTTGSKLVIVESPAKAKKIGGYLGDGYTVLASVGHIRDLAQPSQVPADEKAKFGKFGVDVNDGFKPYYIVGPEKKKTVSELRSALRNASELYLATDEDREGEAIAWHLVQTLKPKVPVKRMVFHEITPEAIRASLEHTREVDNNMVDAQETRRVLDRLYGYELSPVLWRKVGPGLSAGRVQSVATRLIVERERERMAFVRAPYWDVVATLCAPDALGEPTDFESRMIALNGTRLATSKDFKSDGTLTDAARTDGVVQLGESQAGDLADALADARFRVISVEKKPYRRRPQPPFTTSTMQQAAGNRLGMSSRQTMRAAQSLYENGYITYMRTDSVTLSHEAIEAARESVSKNFGSQYLSEKPKQYATKTAGAQEAHECIRPAGSHFRDPSQLATLPPDQLKLYTLIWQRTLASQMADATGSTATARFAASAGGLGEATFQSSGTVIEFPGFMRVTGERGGSGKKGEESASLPPLAESAELPAKSVLADGHETQPPARYTEASLVKTLEAKEIGRPSTYANIISTIIDRGYVYERGRALIPSWLAFAVTRLLETKFPKYVDYQFTADMENGLDQIAHGNETGREWLTQFYFGSGADSARSADEAHEGLQRQVAQLGEIDAREINTIPIGDGIHVRVGRYGPYLEDTKDLDAEGNPKRASIPDTIAPDELTVGEARKLIASNAGGPRVLGTDPATGGTVEVRNGRFGPYVALVAPESAHESAPTGKKKAAEPKPKMASLFKSMKPETVTLDDALRLLSLPRTVCTYDEVDAKTGETVSVTISASNGRYGPYLTKTRADGGASETRSLESEDAIFTVDETHAQALFAQPKYGRGRGAAKPPLRTLGPDPESKREVSIKEGFYGAYITDGETNRSLPKQYDPKTISAEDAFRLLAEKRAAGPSKRRGRKGKASAKSTGKGTAKGRKSAPKKSATETARDRRRKQVRELAEQGWANTRIAKEIGSSAATVKADVEYLEANEGFKRPPVVPAK
(152) DNA topoisomerase 1 [Gardnerella vaginalis HMP9231]
8
MTEQNKLVIVESPTKARKIGGYLGSGYTVMASVGHIRDLAQPSQVPAAKKAEFGKFGVDVNNGFEPYYVVGADKKKTVSDLKAALAKSGELFLATDEDREGEAIAWHLVQALKPKVPVKRMVFHEITKDAIQASLANTRNVDDHMVDAQETRRVLDRLYGYELSPVLWRKVGPGLSAGRVQSVATRLIVERERERMAFKKASYWDVCADLSANGVDFQARMTALNGERLAASKDFNSLGELQKTKGESALAHYLNEADACAIAQSLGAADFVVSSMDTKPYRRRPLPPFTTSTLQQTAGNRLSMSSRQTMRAAQSLYENGYITYMRTDSVTLSKEAIFAARDCVKSSFGDEYLADSPKQYATTSAGAQEAHECIRPAGSTFRNPADLAGVLPADQLKLYTLIWQRTLASQMADATGFTATVKLDASAGSFGTANFQASGTVIEFAGFMKVFGGFSEDEQSKALPPMANGDVLKALRVSADGHETQPPARYTEASLVKTLEAKEIGRPSTYASIISTIIDRGYVYERGRALIPSWLAFAVIKLLESNFPTYVDYAFTADMENGLDRIAHGEEAGKDWLYKFYFGDNGAVAGDFAMHEGLQKQVDQLGEIDAREINTIDIGGGLHVRVGRYGPYLEDTKNLDEEGNARRASIPSTLAPDELTEQVARDLIENNSDGPRVLGTDPQTGGSVEVRNGRFGAYVALVEASDEDESQASDDSAKTGAKSSAKSKKSAKAKPKMASLFKTMDPATITLQDALRLLNLPRLVGIVEEVDEQGEVKRAKIEANNGRYGPYLTKTYERADAGDSAAAVDAKPDNRSLASEDAIFSVTLDEAKELFAQPKYAKRTRGAAKPPLRELGEDPESGKAVVIKDGFYGAYITDGVTNRTLPKQYTPESIEPQVAFELLAQKRAAGPVKRKRTAAKKTATKKTAAKKTAAKKPAAKKSTAKKSTSKVE
(1419) DNA topoisomerase I [Coriobacterium glomerans PW2]
3
MVLVIAEKNIAAKKIAQLLADGAPKTDKVYSTQVYRFSVDGEEWVSMGLAGHILAPDFPEAILFDAERGWYSLTDDGEILPADVPDGLARPPYDSKRRPYLPDGINIKSWKVDSLPYLTWAPVVKHPAEKEIIRVLKNLAKKADSIIIATDFDREGELIGADALSQVREVAPDVPVARARYSALIKGEVCGAFDNLVELDRDLADAGESRQHIDLIWGAVLTRYLTLAKFGGFGNVRSAGRVQTPTLALVVARERERLAFVPEDYWQIRGIGASGDTAFKIAHATARFTDEQKAKTAFAHVQGKTSGTIVKVATRARKQAPPAPFNTTSLQAAAASEGISPARTMRIAESLYMSGLISYPRVDNTVYPPSEDLAAIVSGLAASSPALAPVCKKVLAGPMKPTRGKTETTDHPPIHPTGQGSPESLDGGQRKLYNLIARRFLATLMGPATIENTKLSIDVAGEPLTASGDVLVTAGFREAYPYGLKRDEQLPPLSAGDVIEVRDLALEAKQTEPPARYSQGRLVQEMEKRGLGTKSTRASIIERLYQVRYLKNDPIEPSRLGMAIIDALAAYAPRITTPDMTAELDGDMTKVAEGADTEAHVVDHSRALLAGLIDNLIDHKDDLGEAISDAVTADAKVGVCPTCGRDLVMKASAKTRGNFIGCMGWPECDVTYPVPSGVKLEPIEGDDGVCPECGAPKIKCKPFRSKAYEVCVNPRCPTNYEPDLKVGECAVCAEAGRHGDLIAHKSERSGKRFIRCTNYDECAVSYPLPARGKLQATGETCEHCGSPIVVVETARGPWRICVNMDCPGKEKRPARGRRGTAAASKPAAKKTAAAKKSAAKKSPAKRKPAAKKTAAAKKTAAAKKSASSR
(586) DNA topoisomerase 1 [Streptomyces griseus subsp. griseus NBRC 13350]
8
MSPTSETAQGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPDEYTGEVRRLGVDVEHDFQPIYVVNADKKAQVRKLKQLLAESDELFLATDEDREGEAIAWHLQEVLRPKVPVHRMVFHEITKDAIRAAVANPRELNQRMVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGKFATGRTGDASDPSNLTARLSAVDGRRIAQGRDFGPDGQLKAGSAQTLHLDETNARALAAALADSSFTVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSDTAVAAARAQVTQLYGASYLPEKPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIWKRTVASQMKDATGNSVTVKIGGRASDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVAEGDALSADEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRISRGEAQSVPWLKRFYFGADAGDDTAGAGSASDAGNGDGDHLGGLKALVTDLGAIDAREISSFPVGNDIKLRVGRYGPYIERGEKDAEGHQRADVPEDLAPDELTVELAEELLAKPSGDFELGADPATGNQIIAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLADALKLMSLPRVVGEDAEGVEITAQNGRYGPYLKKGTDSRSLTSEDQLFDITLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSGAPVVVKDGRFGAYVTDGETNATLRTGDSVEEITPERGYELLAEKRAKGPAKKKTAKKAPAKKATAKKTAAKKTTATKTAAAKKTTAKKTTTAKKATTQKATATKTAAKKTTSASAAPSDD
(1167) DNA topoisomerase 1 [Xylanimonas cellulosilytica DSM 15894]
8
MATKLVIVESPTKARKIAGYLGAGFEVEASVGHIRDLPQPSELPAEMKKGPFGKFAVDVENGFEPYYEVYADKKAKVRELKKLLKDADELYLATDEDREGEAIAWHLIQELKPKVPVRRMVFHEITKEAILRALENTRDLDTDLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVTASYWDVTGSFAPTAGDDAGVVFSARLSGIGGERVATGRDFDDRGRLKVRTGVVHCSQAVAQAVVTGLDGADFAVRSLETKPYTRKPAAPFTTSTLQQEASRKLRMNARATMRTAQSLYENGYITYMRTDSPALSAEAIDAARRQAAELYGSEFVPGTPRLYQSKSAGAQEAHEAIRPAGDSFRTPAQVARELSGDQFRLYELIWKRTVASQMADAKGSTASVRLGAVLSAAAGDLAGKDAIFSASGTVITFRGFLAAYEEGTDTEDSPEARAATPKDARLPRMAQGDGLDARDLTADGHSTTPPARYTEASLVKALEELGIGRPSTYAATISTIQDRGYVRTSGQAMIPTWLAFAVTKLLEDHFGSLVDYRFTAEMEQDLDEIAEGRRARGAWLEEFYFGDREAAAGSDAVGTLATSGLKGLVDGLGEIDPVAVNSVELGEGLRLRVGRYGPYVEDLSAPVAEGATPQRASVPDDLAPDELTVEKARELLAAGGDDGRSLGVDPVSGHEIVAKAGRYGPYVTEVLPEPVLDEGLSAAAKKRALAALPKPRTGSLFKDMDLATITLDDALKLLSLPRVVGVDPADGVEITAQNGRYGPYLKKGTDSRTIASESMLLTVTLEEALAIYAEPKRRGARGAAQPPLRELGDDPTSGKPIVVKDGRFGAYVTDGETNRTLPRDVTPETITPERAIELLAEKRAAGPAKKRTTTRKAPAKKAPAKKAPAKK
(588) DNA topoisomerase 1 [Tropheryma whipplei str. Twist]
1
MKKLVIVESPTKVSSVGRYLGDGYVVMSSVGHIRDLPAPSGLTPDLKRSAHAQFAVNIENDFEPYYVVLENKKKVVEELQSALNNSDELLIATDGDREGEAIAWHLVQVLKPTVPVRRLVFHEITREAIAYALQHPRPIDENLVDAQEARRILDRLYGYELSPVLWKKVRPGLSAGRVQSPATRLLVDRERERINFKSAEYQAVTADFQVDSDVFSASLTLFGERKIATGRDFDNLANLKTDALVLDKNLTDRILEELKSKGALDVEAIDSKPYSRNPYAPFITSTLQQDAAHKLGFSAKRTMRTAQQLYEKGFITYMRTDSPRLSLQAISAARAQVELLYGREFLPDSPRTYGAKAKNAQEAHEAIRPTGEVFERPESIESVLSVDCMRLYDLIWRRTIASQMVSARGETVTLTLSARIPERSIFVLSGTVLHEKGFLKVYEGLQDLNSKLLPNLQVGDQVTLVDVRAVGHTTLPPPRYTEASLVKVLEELGLGRPSTYALILSTIQERGYAHLRNRMLVPDWLAFSVVNLLENFFSRLIDYDFTANLEDQLDEIALGSQNRSDWLRKFYFGDDNLPGLKEIISGAKDIDARAINSIPMVGATLRVGRYGPYLEVGDKRFSIPHDVYPDALTPEKIHELVNQPESPVRELGAHPETGKLVVLKSGRFGPYIEEVSDEKNVRRSSLFKNMDPEEVNLDVAVKLLEIPRVIGVNQENGEKVIACNGRFGPYIKCGKETRPLDSEDDILSVTLDEALAILSAPKVRRSRVLMEFPTDDPVTRRAVQIKSGRFGPYVTDGVTNATLDNTSWEDVTFDEAVSLLAEKRQRVDGDLDQETAEKIHV
(902) DNA topoisomerase 1 [Corynebacterium urealyticum DSM 7109]
8
MKRLVIVESATKAKKIAPMLGSDYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNVDKGFEALYVVSPDKKKRVADLRAKLKQVDELLLATDPDREGEAIAWHLLEVLKPKVPVRRMVFHEITKSAILEAVENTRELDYNLVDAQESRRVLDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFRAADYWDLTAELTIDPAARLDGDPASFQAKLATVGGQRIAQGRDFKDDATLKASKSGAPLVLDEQRAKQLASGIKGEELHVANVEEKPYTRRPYPPFMTSTLQQEAGRKLRFTSERTMRIAQRLYENGYITYMRTDSTTLSTAGINAARAQAAQLYGQQFVADGPRQYTRKVKNSQEAHEAIRPAGERFQTPGQLAQKLDAEEFKLYELIWQRTVASQMADARGTSMKVTIAGTSGEPEAGTEVEFTATGRTVTFPGFLKAYVEVSRTAEGKDVADNAEKRLPQVTEGVFLTAEDVTADGHTTTPPARYTEASLVRKMEELGIGRPSTYASIIRTIQDRGYVLPRGNALVPSWVAFAVVGLLEQNFGALVDYDFTSAMEDQLDAIAEGNEDRTKWLEGFYFGGGTSSQNYGLKNVVAQNLESIDARRVNSLHLFDDANGVPIVVRVGRYGPYLERMVKNDKGEEEAQRANLPESMTPDELTLEVAEKLFATPQSGRELGRNPENGRMIVAREGRFGPYVTEVLGEDEEAEVTAKAEKVFLAERDEEDAERAKEGKKPLSRGTKTFENKKAKRIKEILEETLKPKTASLFASMEPATVTLEDALKLMSLPREVGVDPADGEVITAQNGRYGPYLKKGWDSRSLGSEEELFNITLDEARRIYAEPKRRGRAAAKPPLKRLGDNDVSGKPMSVKEGRFGPYVTDGTTNASLRRGDTPETLTDARANELLSERRAKDAEKAAAGPAKSTRKSTKKTAKKAAKKATKRSTKKTAKKAAKKAAKKA
(1852) DNA topoisomerase 1 [[Cellvibrio] gilvus ATCC 13127]
8
MSAGRKLVIVESPAKARTIAGYLGDGFDVEASVGHIRDLPQPSELPADMKKGPFGKFAVDVENGFTPYYVVDSDKKKKVAELKKLLKESDELYLATDEDREGEAIAWHLLSELKPKVPVKRMVFHEITREAITRALENTRELDDRLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVPADYWDVTGTFAVADDDEPTFSARLSALDGRRVATGRDFSDRGVLTSDSAHLDEAAATSLVAALDRADFEVRSLETKPYTRRPAAPFTTSTLQQEASRKLRMSSRQTMRTAQSLYENGYITYMRTDSPVLSSQAISAARRQAAELYGGEYVPDAPRVYASKAKGAQEAHEAIRPAGDHFRTPAQVARELSGDQFKLYELIWKRTVASQMADARGQTASVRLGAVASDGRDAVFSASGTVITFRGFLAAYEEGRDVSRYDDDAPAAPADDKDARLPKMAQGDALTAADLTADGHRTSPPPRFTEASLVKALEERGIGRPSTYAATISVIQDRGYVTSRGQALVPSWLAFAVTRLLEDNFEWLVDYDFTAEMEQDLDAIAAGDKDRVAWLTRFYFGDGTGRTEGEGLRDLVENLGEIDAREVNSIAIGDGIVLRVGRYGPYLEDPAVLGEDGNPRRASVPEELAPDELTVAKARELLDSEPEGDQVLGTDPTSGTTIVAKKGRYGPYVTELLPEPEIDPSLSAAAKKKALAAAPKPRTASLFKSMSLDTITIDDALRLLSLPRVVGTDPESGAEITAQNGRYGPYLKKGTDSRTLASEEALFTTTLEEALAIYAQPKRGRGATATPPLRELGTDPTSGKPIVVKDGRFGLYVTDGETNRTLPRDVTAESITPEQAIQLLADKRASAPAKKKAPARRTAAKPRAAAKK
(259) DNA TOPOISOMERASE I (OMEGA-PROTEIN) [Corynebacterium glutamicum ATCC 13032]
3
MTIGILTEKASAAKNFAKALGGPSGTYNGEKYVIAAASGHLYEFVEPEEMVPPSYADKIGGYWDLAKLPWDETQFLWSREQKHGAANTIARIKKTLSSCTTIVIGSDIDPTGEGDLLAWEIIAELGLDTKKIQRMEFVDEAPASIQQAFINRRDVTSMHDEPNYLKAEFRSRFDLLSMQWTRGATKVLETTGRRAVLRNGRLKSAMVAIVGQGLDAYNDYKKIPFYQNRFIDDHGVSYVNPEEPRYKTCDEVPQLYKASAVECYEKSMKKTAPPRLLDLASLSALLSKEGFSAKNVLKTYQQMYEAQVVSYPRTEDKTITPEQFKELAPLVDKIAGLVGVNPADLTHRQPRSTHVKPKGAHGANRPGLNVPTSIAAVKTTYGVLGQRIYEVLAKSYLTMLAEDYLYEHQKGRVVDYPAFLGTANVPKSLGWKGIFDVDAEADDDAAGSDAAQQGIGTRAEPEVFEGFPQRPPHPSMTWLMKQLDKHDVGTGATRTSTYAEVTAGKSALLKETRGKVTMTDAGQLNYLLLPGTHIGDLKLTERVYADMAAVAAGEKTAEQALEPVKQWVEEDIATMTRNAKNIPQELGKKLMTTTFTPSVKHSGTWNGEQVSFKKVYCGHEFSDAECEALLRGEELTITDAMIGGQITTVTGKLAHQSFNKDGKTIKFFGFKGQVDRIASADPAVYAVGVWKVEGEKIRFKRVWGGHKFTDKEIADLLEGREIAFDAMSKAKKPYTARGSLQRGEYNGNSFVGFQLAPRD
(467) DNA topoisomerase 1 [Corynebacterium glutamicum ATCC 13032]
8
MADTAGTTGSKKKYLVIVESATKAKKIQPYLGNDYIVEASVGHIRDLPRGAADIPAKYKKEPWARLGVDTDRGFAPLYVVSPDKKKKVADLKAKLKLVDELLLATDPDREGEAIAWHLLEVLKPTVPVRRMVFNEITKPAILAAAENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFVSADYWDLSAEFNARENGKADSDNPSSFTARLSTIDGNRVAQGRDFNDRGELTSEAVVVDKQRAEALAEALEGQEMAVVGVEEKPYTRRPYAPFMTSTLQQESGRKLHYTSERTMRIAQRLYENGHITYMRTDSTSLSEQGMKAARDQALELYGAEYVSPSPRTYDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTIGGTAKTGEKTEFNATGRTLTFPGFLRAYVETTRTADGRDVADNAEKRLPLLSEGDLLKVLSIEADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGREGRTEWLNGFYFGDAEADQSMAESVARQGGLKALVDANLEHIDARSVNSLKLFDDAEGRAVNVRVGRYGPYIERIVGTTAEGEPEFQRANLPEETTPDELTLEVAEKLFATPQGGRELGINPANGRMVVAKEGRFGPYVIEQVTDSERAGAEAQAEEVVAAERKAEDEQRATDGMRPKNWETKTAANQKEKRINQLVEENLKPATASLFSGMEPATVTLEEALKLLSLPREVGVDPSDNEVITAQNGRYGPYLKKGSDSRSLNSEEQIFTVTLDEARRIYAEPKRRGRAAAQPPLKQLGDNDVSGKPMTVKDGRFGPYVTDGTTNASLRKGDVPESLTDARANELLSERRAKEAADGGAPAKKTSTKKTAAKKTTAKKTTAKKTVRKAPPKTTKNVVKAGAKKKS
(260) DNA TOPOISOMERASE I (OMEGA-PROTEIN) [Corynebacterium glutamicum ATCC 13032]
3
MTIGILTEKASAAKNFAKALGGPSGTYNGEKYVIAAASGHLYEFVEPEEMVPPSYADKIGGYWDLAKLPWDETQFLWSREQKHGAANTIARIKKTLSSCTTIVIGSDIDPTGEGDLLAWEIIAELGLDTKKIQRMEFVDEAPASIQQAFINRRDVTSMHDEPNYLKAEFRSRFDLLSMQWTRGATKVLETTGRRAVLRNGRLKSAMVAIVGQGLDAYNDYKKIPFYQNRFIDDHGVSYVNPEEPRYKTCDEVPQLYKASAVECYEKSMKKTAPPRLLDLASLSALLSKEGFSAKNVLKTYQQMYEAQVVSYPRTEDKTITPEQFKELAPLVDKIAGLVGVNPADLTHRQPRSTHVKPKGAHGANRPGLNVPTSIAAVKTTYGVLGQRIYEVLAKSYLTMLAEDYLYEHQKGRVVDYPAFLGTANVPKSLGWKGIFDVDAEADDDAAGSDAAQQGIGTRAEPEVFEGFPQRPPHPSMTWLMKQLDKHDVGTGATRTSTYAEVTAGKSALLKETRGKVTMTDAGQLNYLLLPGTHIGDLKLTERVYADMAAVAAGEKTAEQALEPVKQWVEEDIATMTRNAKNIPQELGKKLMTTTFTPSVKHSGTWNGEQVSFKKVYCGHEFSDAECEALLRGEELTITDAMIGGQITTVTGKLAHQSFNKDGKTIKFFGFKGQVDRIASADPAVYAVGVWKVEGEKIRFKRVWGGHKFTDKEIADLLEGREIAFDAMSKAKKPYTARGSLQRGEYNGNSFVGFQLAPRD
(468) DNA topoisomerase 1 [Corynebacterium glutamicum ATCC 13032]
8
MADTAGTTGSKKKYLVIVESATKAKKIQPYLGNDYIVEASVGHIRDLPRGAADIPAKYKKEPWARLGVDTDRGFAPLYVVSPDKKKKVADLKAKLKLVDELLLATDPDREGEAIAWHLLEVLKPTVPVRRMVFNEITKPAILAAAENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFVSADYWDLSAEFNARENGKADSDNPSSFTARLSTIDGNRVAQGRDFNDRGELTSEAVVVDKQRAEALAEALEGQEMAVVGVEEKPYTRRPYAPFMTSTLQQESGRKLHYTSERTMRIAQRLYENGHITYMRTDSTSLSEQGMKAARDQALELYGAEYVSPSPRTYDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTIGGTAKTGEKTEFNATGRTLTFPGFLRAYVETTRTADGRDVADNAEKRLPLLSEGDLLKVLSIEADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGREGRTEWLNGFYFGDAEADQSMAESVARQGGLKALVDANLEHIDARSVNSLKLFDDAEGRAVNVRVGRYGPYIERIVGTTAEGEPEFQRANLPEETTPDELTLEVAEKLFATPQGGRELGINPANGRMVVAKEGRFGPYVIEQVTDSERAGAEAQAEEVVAAERKAEDEQRATDGMRPKNWETKTAANQKEKRINQLVEENLKPATASLFSGMEPATVTLEEALKLLSLPREVGVDPSDNEVITAQNGRYGPYLKKGSDSRSLNSEEQIFTVTLDEARRIYAEPKRRGRAAAQPPLKQLGDNDVSGKPMTVKDGRFGPYVTDGTTNASLRKGDVPESLTDARANELLSERRAKEAADGGAPAKKTSTKKTAAKKTTAKKTTAKKTVRKAPPKTTKNVVKAGAKKKS
(286) DNA topoisomerase 1 [Corynebacterium jeikeium K411]
8
MANDDVKRLVIVESATKAKKIAPILGPNYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNVDKDFEALYVVSPDKKKKVSDLKAKLKQVDELYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFHEITKNAILEAAQNTRELDYDLVDAQESRRVLDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMKFIAAEYWDLSATFGVVDAVSSSLDDAAPDSFEARLATVAGKRVAQGRDFGDDGKLKASAKETFVLDGAKAKSLADGLQGQEFTVTAVEEKPYTRRPYPPFMTSTLQQEAGRKLRFTSERTMRIAQRLYENGHITYMRTDSTTLSTAGIEAARKQAKELYGAKFVADGPRQYSRKVKNSQEAHEAIRPAGETFQTPGQLSNQLDAEEFKLYELIWQRTVASQMADAKGQSMKLTVAGDAKSGETCEFTATGRTLTFPGFLKAYVEVSRTADGRDVADNAEKRLPQLTKGDELNARDVAADGHSTNPPARYTEASLVKKMEEMGIGRPSTYASIIRTIQDRGYVLPRGNALVPSWVAFAVIGLLEQNFGALVDYDFTSAMEDELDAIAAGNEDRVNWLKGFYFGDSSRPDAPGAVVPRLGGLKHIVGDNLEQIDARRVNSLHIFDDENGVPIVVRVGRYGPYLERIKPVPQGAPEGTEPEVQRANLPESMSPDGLTLEVAEKLFATPQGGRELGTNPANGRTIVAREGRYGPYVTEVLGEDEESRVAEEAVKVWEAERDEQDREREAEGKKPLSRETKTAQAQKEKRVKQIVEETLKPKTASLFSDMEPASVTLEEALKLMSLPREVGVDPSDNEVITAQNGRYGPYLKKGKDSRSLANEEQIFTITLDEARRIYAEPKRRGRAAAQPPLKQLGDNDVSGKPMSVKEGRFGAYVTDGTTNASLRKGDTPETMTDARANELLSERRAKQAAEGSAPAKSSRKAAKKSAKKTTKKAAKKTTKKTAKKPPTLTKRTVKKSR
(621) DNA topoisomerase 1 [Corynebacterium aurimucosum ATCC 700975]
8
MAEATGPGKTLVIVESATKAKKIQPYLGDKYIVEASVGHIRDLPRGAADVPAKYKKESWARLGVNPEDNFTPLYVISQDKKKKVADLKAKLKQCDQLYLATDPDREGEAIAWHLLEVLKPKVPVRRMVFNEITKSAILEAAENTRELDENLIDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFIPAEYWDLTATLKSTPDFDARLSALDGKRVAAGRDFDDRGQLKSDEVVVVKQAQAEQLASALEGSTMTVASVEHKPYSRKPSAPFMTSTLQQEAGRRLHYTSERTMRIAQRLYENGHITYMRTDSTSLSKQGLDAAREAATSIFGAEFVADGPRTYDRKVKNSQEAHEAIRPAGERFATPGQLAGQLDAEEYKLYELIWKRTVASQMADAKGTSMKVTAAVSAGGHDADFSATGRTITFPGFLKAYEDVASKGSKEESRLPHLNEGDTLKTAAVTADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVLSRGNALVPSWVAFAVVGLLENNFTELVDYDFTSSMEDELDAIAAGSENGTDWLNNFYFGNTEAGERKAASIARHGGLKSLVDINLEAIDARQVNSLRLYTDAEGRDVFVRVGRYGPYIERAVGTNEDGTVEYQRANLSETVTPDELNEALAEKLFATPQGGRELGQNPENGRTIVAKEGRFGPYVTEQVRDDEREKAEAEAEEIVKEERAAEDAQRAAEGKRAKNWETKTAAKQKEKRIAEYVEEKLKPGTASLFASMEPSSVTLEEALKLLNLPREVGVDPSDGEVITAQNGRYGPYLKKGKDSRSLAKEEQIFSITLDEARRIYAEPKRRGRAAAQPPIKQLGDNDVSGKPMTVKDGRFGPYVTDGTTNASLRRGDDPEQLTDARANELLSERRAKDAANGGAKKSTKKSTKKSTKKATKKSSKKATKKPSPGTKNVVKAGSRRK
(1282) DNA topoisomerase 1 [Nocardia farcinica IFM 10152]
8
MYSPVATRDRGAADQGRPLRRLVIVESPTKARKIAPYLGRNYTVEASVGHIRDLPRGAADVPAKYKGQPWARLGVDVDNDFEPIYVVSPDKKAKVTELKSLLADADELYLATDPDREGEAIAWHLLETLKPKVPVRRMVFHEITEPAIRAAAADTRELDPDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRVIVQRERERMAFRSAEYWDIAAKLDAGADEQSDAANPRTFGARLVNVDGARVASGRDFGPDGQLKSASGVVVLDEARARRLAEALDGVDLAVTSAESKPYSRKPYPPFMTSTLQQEAGRKLRFTSERTMRVAQRLYENGYITYMRTDSTTLSESAIAAARSQATQLYGAEYVHPSPRQYNRKVKNAQEAHEAIRPAGDTFATPGQLHSRLDNDEFRLYELIWQRTVASQMADARGTTLTLRITGVAGTGEECVFSASGRTITFPGFLKAYVESVDEEAGGQSDDAESRLPALEEGQNVTAVELNPDGHSTNPPARYTEASLIKALEELGIGRPSTYSSIIKTILDRGYVYKRGSALVPSWVAFAVVGLLEAYFGRLVDFDFTAAMEDDLDAIASGRERRGNWLSSFYFGGDSGVEGSVARSGGLKKMVGEQLDDIDAREVNSIKLFTDAEGRDVVVRVGRYGPYLERLVTDPDDPDGDPISQRANLPDDLPPDELTPEVAEKLFATPQEGRSLGVDPATGHEIVAKEGRFGPYVTEILPEPATEEGAKKTAAKKTAPKPRTGSLFKSMDLASITLDDALKLLSLPRVVGTDPATGEEITAQNGRYGPYLKKGTDSRSLASEDQIFTITLDEALKIYAEPKRRGGQSASAAPLRELGTDPVSGKPMVIKDGRFGPYVTDGETNASLRKGDEVESITDERAAELLADRRARGPVKKTAKKAAKKTAAKKTTATKTAATKTAATKTTAKKTTAKKTTAAKKTAAKKAPAKSTAENS
(43) DNA topoisomerase 1 [Gordonia polyisoprenivorans VH2]
8
MAETSTTSPTSGKAIRRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRGAADVPAKYKGQSWARLGVNVDENFEPLYVVSPDKKSTVTELKSLMRDVDELYLATDGDREGEAIAWHLLETLKPKIPVKRMVFHEITEPAIRAAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIIVERERERMAFVSAEYWDIDATMNAGGSQEDESNPRSFSARLVNVDDARVATGRDFTPKGVLKKADGVIVLDESRATALAGALDGADMTVTSVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSSDRTMRIAQRLYENGFITYMRTDSTTLSESAINAARTQARELYGDNFVHPTPRQYTRKVKNAQEAHEAIRPAGETFRTPGQVAGQLETDEFRLYELIWQRTVASQMADAKGTTLSLRITGTATSGEECTFAASGRTITFPGFLSAYVETVDDQAGGQADDAENRLPQLTEGQSLTASELRADGHSTNPPARFTEASLVKVLEELGIGRPSTYASIIGTIQDRGYVVKKGNALVPSWIAFAVVGLLEAYFESLVDYDFTASLEDDLDQIANGQENRTRWLTEFYFGDSAANAEHDAEIAGSEIAKHGGLKKLVGVNLEEIDAREVNSIRLFDDEQGRPVYVRVGRFGPYLERNVAASADAEPDLQRANLPADMTPDELTLAVAEKLFSTPQEGRTLGTDPVTGHEIVVKEGRFGPYVTEILPAEEDGDDSGSAGAPATIPAGPTPRDGGGAGDGEVVPLDDTPADTGGSTSGGSTATKTAAKKAVAKKAAAKKTAKKAAGPKPRTGSLFKTMDISTVTLDDALKLLSLPRVVGVDPASNEEITAQNGRYGPYLKKGTDSRSLTSEDQLFSITLDEALKIYSEPKRRGRAAAAPPLRELGKNDEVSGQPMVIKDGRFGPYVTDGETNASLRKGDEVASITPERAMELLADRRARGPAKKATKKAAKKTPAKKTAAKKTTAKKTAAKKTTAKKTTAWKTAAKKTAPDATED
(1200) DNA topoisomerase 1 [Mycobacterium bovis AF2122/97]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(385) DNA topoisomerase 1 [Mycobacterium vanbaalenii PYR-1]
8
MADEERGSGKNGAEPRRGNGSSVRRLVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRNAADVPAKYKSEPWARLGVNVEHNFEPLYIISPDKKSTVADLKDKLKNVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERERMAFRSAGYWDVTAELDASVSDAQASPPTFVAKLNTVDGRRVATGRDFDSLGAVRKPDEVLVLDEAAANALATGLRGAQLAVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRFTSERTMSIAQRLYENGYITYMRTDSTTLSQSAIDAARNQARQLYGEEYVHPTPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSQLDTDEFRLYELIWQRTVASQMADARGTTLSLRIAGAAPATTLGGGTASDVQVVFNASGRTITFPGFLKAYVESIDDLAGGEADDAESRLPNLTQGQRVDAKGLTADGHTTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVIGLLEQHFGRLVDYDFTAAMEDELDEIAAGHERRTNWLNNFYFGGEHGADGSIARSGGLKKLVGGNLEEIDAREVNSIKLFDDAEGRAVNVRVGRNGAYLERMVADPDNPGELKPQRANLKDELTPDELTLELAEKLFATPQEGRSLGVDPATGHEIVAKDGRYGPYVTEVLPEPPDEGEAGATAKKGKKPTGPKPRTGSLLRSMDLETVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLEEALKIYAEPKRRGRQGAATPPLRELGVDPVSEKPMVIKDGRFGPYVTDGETNASLRKGDDVLSITDARASELLADRRARGPVKKKAVKKAPAKKTPAKKTAAKKAAKKA
(1065) DNA topoisomerase 1 [Mycobacterium rhodesiae NBB3]
8
MADGNVRRLVIVESPTKARKIAGYLGSNYIVESSRGHIRDLPRNAADVPAKFKSEPWARLGVNVEDDFEPLYIISPEKKSTVAELKDLLKSVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAADDPRDLDNDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVSRERERMAFRSAGYWDVTAELDASVSNAQASPPTFTAKLNSVDGRRVATGRDFDSLGGLKKPDEVLVLDQSAAGALAAGLRGAQLEVSSVEQKPYTRRPYAPFMTSTLQQEAGRKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQATQLYGQEYVHPSPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHAQLDTDEFRLYELIWQRTVASQMADARGTTLSLRISGSSSDGQQVVFSASGRTITFAGFLKAYVESIDEQAGGEADDAESRLPNLEQGQRVDAKELTADGHTTSPPARYTEASLIKALEDLGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFSRLVDYGFTAAMEDELDEIASGNERRTNWLHNFYFGGDHGVEDSIARSGGLKKLVGVNLEGIDAREVNSIKLFDDDQGRAINVRVGRNGPYLERMVPDPDNSGELKPQRANLNDELTPDELTLELAEKLFSTPQEGRSLGVDPATGHEIVAKDGRYGPYVTEVLPTPDEPDDDAGSTAKKGKKPTGPKPRTGSLLRTMDLETVTLDDALRLLSLPRVVGVDPTTNEEITAQNGRYGPYLKRGTDSRSLATEEQMFDITLDEALKIYSEPKRRGGQRAAAPPLRELGNDPATDKPMVIKDGRFGPYVTDGETNASLRKGDDVMSLTDGRAAELLADRRARGPVKKKSTKKAAKKKAPAKKAAKKA
(641) DNA topoisomerase 1 [Amycolicicoccus subflavus DQS3-9A1]
8
MAARGSGTANGSARAGDSRVVRRLVIVESPTKAKKIASYLGSGYVVESSRGHIRDLPKGAADVPAKYKGEAWARLGVNVDEDFEPLYVVSADKKATVSELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPKIPVRRMVFHEITEPAIRAAAENPRDLDSDLVDAQETRRIVDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIIVQRERERMEFTAAEYWDIAATLDAGSGVTPQTFGAKLMSVGGERVATGRDFGPNGALKSSSAVRVLDEAHAGRLAEALQGQALAVTSAEEKPYTRRPYAPFMTSTLQQEAGRKLRFSADRTMRIAQRLYENGYITYMRTDSTTLSSSAIDAARNQARELYGPEYVAPSPRQYTRKVKNAQEAHEAIRPAGETFQTPGQLHRVLEADEFRLYELIWQRTVASQMADAKGTTLSLRITGTAATGEECVFSSSGRTITFPGFLSAYVETVDEEAGGQADDEERRLPRLTEGHAVTASELRPDGHSTSPPSRYTEASLVKKLEDEGIGRPSTYASIIKTIQDRGYVYKKGNALVPSWVAFAVVGLLERHFGRLVDYNFTASMEDDLDAIAEGRERRSDWLAAFYFGSDDRAEGTLAKLGGLKRLVGVNLEGIDAREINSITLFDDSDGRPVNVRVGRFGPYLERTIGEGDAAESQRANLPEDLPPDELTREIAEKLFSTPQEGRVLGVDPDTGHEVVAKEGRFGPYVTEIIPDDEKNGGAKKVKPRTGSLLKSMEISTVTLEEALKLLALPRVVGKDPESGDEITAQNGRYGPYLKKGSDSRSLATEDQIFTVTLDEALKIYAEPKRRGRQAAATEPLREVGNDPATGKPMVIKDGRFGPYVTDGETNASLRKGDEVATLTVERGAELLADRRARGPVKRTAKKTAAKKTTAKKSPAKKTAAKKTAKKSSS
(1796) DNA topoisomerase 1 [Verrucosispora maris AB-18-032]
8
MPSNAGTTRLVIVESPAKAKTISGYLGPGYVVEASFGHVRDLPRNAADVPAKYKGEPWARLGVDVDNGFHALYVVSADRKQQISKLTKLAKEVDEIFLATDEDREGEAIAWHLVETLKPKVPVRRMVFHEITKPAIQAAVANPREIDRSLVDAQEARRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERQRMAFRTAEYWDILATLAVANAGEGPRTFNATLVALNGDRIATGKDFEPTTGKVRAGAGVVHLDSSGARGLAARLEGRPFTVTRVEEKPYRRRPYAPFITSTLQQEAARKLRFSSQQTMRTAQRLYENGYITYMRTDSVNLSETAIAAARRQIVELYGERSVPPEPRRYTGKVKNAQEAHEAIRPAGDNFRTPGDVAKELSAEEYKLYELIWRRTIASQMTDAVGSSVSVRIRATTTAGEEADFGATGKTITDPGFLRAYVESSDDENAEAEDAERRLPNLVKDQPLTADELAAQGHHTQPPARYTEASLVKALEELGIGRPSTYASIMQTIQDRGYVFKRGQAMIPSFLAFAVIGLMERHYPRLIDYDFTASMENELDEIAGGDHAAVDFLTAFYFGTTNGAGDQDIARSGGLKKLVTENLSDIDARSVNSIPLFTDDEGREVVVRVGRFGPYLQRALPGEQPAPKAEGEEGGTPGDRAPIPEGLAPDELTPEKVHELFLGGGGERKLGDDPATGEPILLKSGRFGPYVASGDRKSSLLRSQSPDSLTLDEALKLLSLPRLIGVAPDGAEVFANNGRYGPYVKRGDEFRSLDSEDKMFTVTLDEALALLAAPKTRQRRAAAPPLREMGADPLTEKPLVIKDGRFGPYVTDGETNASLRRGQTPEELTLEEASEMLAEKRAKGPAPKKTAAKKTTAKKTTAKKAPAKATKATAAKAAKATPAKKAAPKKATSARSE
(1271) DNA topoisomerase 1 [Micromonospora sp. L5]
8
MPSNAGTTRLVIVESPAKAKTISGYLGPGYVVEASFGHVRDLPRNAADVPAKYKGEPWARLGVDVDNGFHALYVVSPDRKQQISKLVKLAKEVDEIFLATDEDREGEAIAWHLVETLKPKVPVKRMVFHEITKPAIQAAVANPREIDRDLVDAQEARRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERQRMAFRTAEYWDILATLAVAKPGEGPRTFNATLVALNGDRIATGKDFEPTTGRVRAGAGVVHLDEGGARGLAARLADQPFTVTRVEEKPYRRRPYAPFITSTLQQEAARKMRFSSQQTMRTAQRLYENGYITYMRTDSVNLSETAIAAARRQIVELYGERSVPPEPRRYTGKVKNAQEAHEAIRPAGDNFRTPGEVAKELSAEEFKLYELIWRRTIASQMTDAVGSSVSVRIRAVSSAQEEADFGATGKTITDPGFLRAYVESSDDENAEAEDAERRLPTLVKDQPLTADELAAQGHHTQPPSRYTEASLVKALEELGIGRPSTYASIMQTIQDRGYVVKRGQAMIPSFLAFAVIGLMERHYPRLIDYDFTASMENELDEIAGGDHAAVDFLTSFYFGSTNGTGDQAIAHAGGLKKLVTENLSEIDARSVNSIPLFTDDEGREVVVRVGRYGPYLQRALPGEQQAPTPAPAAPGEGEESGSQGDRAPIPEGLAPDELTPEKVHELFLGGGGERKLGDDPSTGEPIVLKSGRFGPYVASGERKSSLLRSQTPDSLTLEQALQLLRLPRLIGVAPDGVEVFANNGRYGPYVKRGDEFRSLDSEDKMFTVTLDEALALLAAPKTRQRRAAAPPLREMGNDPLTEKPLVIKDGRFGPYVTDGEFNASLRRGQTPEELTLEQASEMLAEKRAKGPAPKKKAAKKAAPAKKTTAAKKTTAAKKTTAAKKAPAKKAAPKKATSTPNE
(671) DNA topoisomerase 1 [Streptomyces avermitilis MA-4680 = NBRC 14893]
8
MSPTSDTAHGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPEKYTGEVRRLGVDVEHDFQPIYVVNADKKAQVKKLKDLLKDSDELFLATDEDREGEAIAWHLLEVLKPKVPVHRMVFHEITKDAIRSAVANPRELNQRMVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFGTGRAGDASDPSSLVARLATVDGKRVAQGRDFDSLGQLKSANTLHLDETNARALATALENTNFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSDTAVAAARAQVTQLYGADYLPAQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKRTVASQMKDATGNSVTVKIAGTAADGRDVEFSASGKTITFHGFLKAYVEGADDPNAELDDRERRLPQVGEGDPLSAEEISVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQAVPWLKRFYFGEGAGTGGAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGNDIVLRVGRYGPYIERGEKDSENHQRADVPEDLAPDELTVDLAEELLAKPSGDFELGTDPATGHQIIARDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLDDALKLMSLPRVVGKDAEGVEITAQNGRYGPYLKKGTDSRSLQSEDQLFTITLQEALEIYSQPKQRGRAAAKPPLKELGEDPVSGKPVVVKDGRFGPYVTDGETNATLRSGDSVEEITPERGYELLAEKRAKAPAKKTAKKAPAKKAPAKKAPAKKTAAKTTAAKKTAAKKTTAKKTVAKKTTASKAAAED
(365) DNA topoisomerase 1 [Streptomyces hygroscopicus subsp. jinggangensis 5008]
8
MSPTSETAQGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPEKYTGEVRRLGVDVDHDFQPIYVINADKKAQVKKLKDLLKDSDELFLATDEDREGEAIAWHLQEVLKPKIPVKRMVFHEITKDAIREAVANPRQLNQKLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFSTGRAGDPSDPSSLVARLQTVDGRRVAQGRDFDSLGQLKSENTLHLDEATARALAAALENTRFSVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKATMQIAQKLYENGYITYMRTDSTTLSDTAISAARAQVTQLYGADYLPPQPRTYAAKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKRTVASQMKDATGNSVTVKIGGTAADGRDVEFSASGKTITFHGFLKAYVEGADDPNAELDDRERRLPQVAEGDALSAEEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIAAGEAKAVPWLKRFYFGEGTATGGAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGNDIVLRVGRYGPYIERGEKDTEQHQRADIPDDLAPDELTVELAEELLAKPSGDFELGTDPATGHAIVAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLDDALKLMSLPRVVGTDADGQEITAQNGRYGPYLKKGTDSRSLQSEDQLFTITLEEAQAIYAQPKQRGRAAAKPPLKELGEDPVSGKPVVVKDGRFGPYVTDGETNATLRSGDSVETITSERGFELLAEKRAKGPAKKTAKKAAAKKTAPAKKTAAKKTAAKKTTAAAKKTTAKKTTAKKATASRATASGAED
(1765) DNA topoisomerase III [Conexibacter woesei DSM 14684]
7
MPKTLVIAEKPSVGRDLSRVLAGPFRRGEGFLEGPDHILTWAVGHLVQLAEPDEYDDKFKRWRMADLPIVPEKFRLVVRDERSKRQMNVVKRQLGRDDIGVVVNACDAGREGELIFAYLYEKAGSRLPVQRLWLSSMTQTAIRNAFGQLRDGAEMKSLEDAARSRSEADWIVGMNSTRAATIRLRSSFDGAVSLGRVQTPTLAILARREEEIRAFRPEPYWTVDATFAASGERVYDGRFHVTAGSGDGRGPRIGSAEFAAAVVEACRGTDGVITKLEKRKRRERVPLLYDLTSLQRDANSRFGFSARRTLAAAQRLYEEHKALTYPRTASRYLPTDMIPEIKPIAEIVGGRSEYAAGARYVLGLDVLPLARVVNDARVTDHHAIIPTRAPHPVDRMGDDDRRIYDLVAKRFLAVFHPDAEFENTSVETEVAGHAFRTRGKVMLVPGWRGVYGESADAEPREGEEDEGREQQLPKLEQGEDVQTREIRSEQKETRPPRRYSEGSLLAAMETAGKLVDEEELREAMKDSGIGTPATRAAIIERLLAVGYIERDGRALVVTEKGLNVIRLLDGHPLTSPSLTGDWEHRLGKIELNEDSRRAFMADIVKFAESTVAELDAKLRDVRIPRANLGPCPVCGHDIMENRKGFSCWSRDDPGCGFVIWKSKAGKTLSGAIARELIRTGRTEKPVTGFRSRAGRSFRSRLALQQTPEGRWRVEFDEPWAREGARPPEAEAGAEAATAEAGGRTTAVAREVAAA
(1647) DNA topoisomerase 1 [Kineococcus radiotolerans SRS30216 = ATCC BAA-149]
8
MAGKSQGTRASGDGLRRLVIVESPSKIDKISTYLGPGYQVEASYGHIRDLPQPSQLPEDVKKGPYGKFAVDVDHGFEPYYVVDDDKKKKVNELKRALKDADELILATDRDREGEAIAWHLVQALEPRVPYRRMVFGEITREAIQQAVGELRDIDDRMVDAQETRRILDRLYGYELSPVLWRKVRAGLSAGRVQSVATRLCVERERERMAFVAAGYADVTGTFTATGEQAGSAFSARLSSLDGKRVATGRDFGDDGRLKASSANVAHLDVPAAQALVDGLDGASFAVRGVEEKPYTRRPAAPFITSTLQQEASRKLRLNARQAMRTAQGLYERGYITYMRTDSVQLSSQALSAARAQARELYGPEYVPDSPRAYASKSKNAQEGHEAIRPAGETFRTPAQVSGELRGDDFRMYDLIWKRTVASQMHDARGTTATVRLGATTDDGRDAEFSASGTIITFRGFLAAYEEGRDATRDADSEGAGDEDRRLPQVVAGDPLTASDLATAGHETSPPARYTEASLVKALEEKGIGRPSTFASIISTIVDRGYVTYKGSALVPSWLAFAVTRLLEEHFPKLVDYDFTAGMENDLDAISRGEAERVDWLTRFYFGAAGPTAGAVVADGPDGSGGGAALDGIKGLADDLGSIDAREISTIPIGEGIVLRVGRYGPYLEGPDVETGELLKASVPEDIAPDEMTVDKARELLTSQSDGDNVLGQDPESGRTIVARVGRYGPYVTELVEDDAPAPAPEEPAEGAPKKRAAKKAAKVKPRTGSLFKDMSVDSVTLEQALQLLSLPRVVGTDPETGDEITAQNGRYGPYLKKGTDSRSLETEDQIFSITLPEVLAIYAQPKMRRGQVAKPPLKELGADPESGQPIVIKDGRFGPYATDGTTNATLRKDDDPETVTLERAAELLAEKRAKGPAKKTARKTATKKTAAKTTTGTATVKKTAAKKTAAKKTTARKTAAAES
(1181) DNA topoisomerase 1 [Saccharomonospora viridis DSM 43017]
8
MAGSTRTKKTGTNGDGRRRLVIVESPTKARKIAPYLGSDYVVESSRGHVRDLPRGAADVPAKYKGQAWARLGVDVDNDFEPLYIITPDKKATVSELKSLLKDVDELYLATDPDREGEAIAWHLLEALKPKVPVRRMVFHEVTEQAIRAAAENTRDLDLNLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIIVERERERMRFTSASYWDIAAVMDVGDADPEATPRSFPARLTMVDGARLATGRDFGPDGRLKEQSQDVRVLDEAEANRLAEALADREFTVVSVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSSERTMRVAQRLYENGYITYMRTDSTTLSESALAAARSQATELYGAEYVADKPRQYTRKVKNAQEAHEAIRPAGEVFRTPGAVAGELESDEFQLYELIWQRTIASQMADAKGTTMSVKIAGTAASGEECVFSASGRTITFPGFLKAYVESVDTEAGGEADDKQSRLPRLVKDQSLTATELRPDSHATSPPSRYSEPSLVSKLEELGIGRPSTYASIIKTIQDRGYVWKKGSALVPSWVAFSVVGLMERHFERLVDYYFTAAMEDELDRIAAGEEERTEWLSRFYFGNGKDDDSSSIGSLGGLKKLVGSGVEDIDAREINSIPMFRDNEGRQVYVRVGRYGPYLEREVDGQSQRANLPEDLPPDELTVEVAEKLFATPQEGRVLGTDPETGHEIVVKEGRFGPYVTEVLPEPEESADGKKTGKAKKPKPRTASLFKSMSVEDVTLDDALKLLSLPRVVGTDPETGEEITAQNGRYGPYLKKGSDSRSLSSEEQIFEITLEEALKIYAEPKRRGRQAAAKPPLKELGEDPVSGKPIVVKDGRFGPYVTDGEYNASLRKSDTVEDLTPERAAELLAEKRAKGPAKKGTARKKTAAAAKSKD
(455) DNA topoisomerase 1 [Amycolatopsis mediterranei S699]
8
MAGARTNKNGASANNGAGHRRLVIVESPTKARKIAPYLGGGYVVESSVGHIRDLPRGAADVPAQYKGEAWARLGVDVDNGFKALYVVTPDKKSKVTELKSLLKDVDELYLATDPDREGEAIAWHLLETLKPKVPVRRMVFHEVTEQAIRAAADSTRELDADLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERERMRFTSASYWDISATMDAGEEASPRNFPARLVAVDGARLATGRDFGSDGQLKASNNEVRVLAEADARRLADALKQRDFKVSSVEEKPYTRKPYAPFMTSTLQQEAGRKMRFTSERTMRIAQKLYENGYITYMRTDSTTLSESAISAARSQATQLYGKEYVSPTPRQYTRKVKNAQEAHEAIRPSGEVFRTPGQVAGELDTDEFRLYEMIWQRTIASQMADAKGTTMSVRIIGNATSGEECTFAASGRTITFAGFLKAYVEAVDTETGGEADDKQSRLPVLEKDQALTAAELSPDGHTTSPPARYSEPSLVSKLEELGIGRPSTYASIIKTIQDRGYVWKKGSALVPSWVAFAVIGLMERHFERLVDYDFTAGMEDELDRIANGDEQRAQWLSKFYFGGDMGVDGSIGRLGGLKKLVEGSVEDIDAREINSIPLFSDENGHTVVVRVGRYGPYLEREVDGNSQRANLPEDLPPDELTQEIAEKLFATPQEGRTLGTDPVSGHEIVAKEGRFGPYVTEVLPEIEIPEDATAAQKKAAKAKAPKPRTGSLFKSMDIENITLDDALKLLSLPRVVGKDPESGDEITAQNGRYGPYLKKGTDSRSLSTEDQLFSITLEEALKIYAEPKQRGRSATAKPPLKELGEDPVSKKPMVVKDGRFGPYVTDGEYNATLRKGDEIESLTAERASELLAEKRAKGPAPKRKAPARKPASTTAKTVKAGTTKKAAAAKPAAAKRSSSTATKAK
(456) DNA topoisomerase 1 [Amycolatopsis mediterranei S699]
8
MAGARTNKNGASANNGAGHRRLVIVESPTKARKIAPYLGGGYVVESSVGHIRDLPRGAADVPAQYKGEAWARLGVDVDNGFKALYVVTPDKKSKVTELKSLLKDVDELYLATDPDREGEAIAWHLLETLKPKVPVRRMVFHEVTEQAIRAAADSTRELDADLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERERMRFTSASYWDISATMDAGEEASPRNFPARLVAVDGARLATGRDFGSDGQLKASNNEVRVLAEADARRLADALKQRDFKVSSVEEKPYTRKPYAPFMTSTLQQEAGRKMRFTSERTMRIAQKLYENGYITYMRTDSTTLSESAISAARSQATQLYGKEYVSPTPRQYTRKVKNAQEAHEAIRPSGEVFRTPGQVAGELDTDEFRLYEMIWQRTIASQMADAKGTTMSVRIIGNATSGEECTFAASGRTITFAGFLKAYVEAVDTETGGEADDKQSRLPVLEKDQALTAAELSPDGHTTSPPARYSEPSLVSKLEELGIGRPSTYASIIKTIQDRGYVWKKGSALVPSWVAFAVIGLMERHFERLVDYDFTAGMEDELDRIANGDEQRAQWLSKFYFGGDMGVDGSIGRLGGLKKLVEGSVEDIDAREINSIPLFSDENGHTVVVRVGRYGPYLEREVDGNSQRANLPEDLPPDELTQEIAEKLFATPQEGRTLGTDPVSGHEIVAKEGRFGPYVTEVLPEIEIPEDATAAQKKAAKAKAPKPRTGSLFKSMDIENITLDDALKLLSLPRVVGKDPESGDEITAQNGRYGPYLKKGTDSRSLSTEDQLFSITLEEALKIYAEPKQRGRSATAKPPLKELGEDPVSKKPMVVKDGRFGPYVTDGEYNATLRKGDEIESLTAERASELLAEKRAKGPAPKRKAPARKPASTTAKTVKAGTTKKAAAAKPAAAKRSSSTATKAK
(44) DNA topoisomerase 1 [Arthrobacter sp. FB24]
8
MPSKAKTGKKLVIVESPAKSKTIAKYLGEGFIVEASIGHIRDLPQPSELPAELKKTSIGKFAVDIEHDFKPYYVVSPDKKKKVTELKAALKDADALYLATDGDREGEAIAWHLLEVLKPKVPVYRMTFGEITKEAIQRAMGNLRDVDQDLVDAQETRRVLDRLYGYEISPVLWRKVARGLSAGRVQSVVTRMVVDRERERMAFKAASYWDLTGQFGAGNGATSSFKAKLAAVDGAKVASGRDFNDDGELTSRNVTHLNEELATSLAAGLQNAEFRVRSVDTKPYTRRPAAPFTTSTLQQEAGRKLRFSSKSTMQVAQRLYENGYITYMRTDSSALSDEAVTAARRQASELYGPEYIPQSPRVYTGKAANAQEAHEAIRPAGDSFRTPAQVAKQLSGDEFRLYELIWKRTVASQMGDAKGSTATIRLGAVAADGRDAEFSASGTVITFPGFLAAYEEGKDESRGDDDSEEARRLPNVAKDDALTASEIVAVGHETSPPPRYTEASLTAELEKKGIGRPSTYASTISTIQDRGYVRKQGSALVPSWIAFSVIRLLEQHFHDYVDYEFTADMEGDLDKIANGQAVGAAWLKHFYYGEDSDPGLLSIVNNLGEIDAREINSVPIAEGITLRVGKFGPYLESSVPTIDPKTGEVVESARANVPEDLAPDELTAAKAKELMETAAPEERVLGEDPHTGHTIVAKNGRYGAYVTEIIPEMTDEQLANQPVEYYKNGKPKPPKKPVKAKPRTGSLFASMSVDSVSLDEALQLMSLPRALGQDAEGNVITVQNGRFGPYLKKGTDSRSIGSEEEIFTITLEQALEIYSQPKQRGARAAVPPLAEFGPDPVSEKNIVVKEGRFGPYITDGITNITVPRSTSLEELTREQAVELLAEKRAKGPAKRPAARKAPAKKKAVAKK
(1514) DNA topoisomerase 1 [Thermobifida fusca YX]
8
MPPKKGSAGDGVKDTARGGGNKLVIVESPAKAKTIAGYLGPGYIVESSIGHIRDLPNKAAEIPARYKDEPWARLGVNVDRDFEPLYVVNADKKAQVKRLKELLAEADELYLATDEDREGEAIAWHLREELKPTIPVKRMVFNEITKEAIRHAAQHTRDLNLRLVDAQETRRILDRLYGYEVSPVLWKKVMPSLSAGRVQSVATRLVVERERERIAFTPAEYWGLKAVFAVLTGTDGADPTTFPATLATVDGDRVAQGRDFTSQGVLRSPKGVRHLDEETARGLAERLAGAQYTVRSVERKPYRRSPYAPFRTTTLQQEASRKLGLSAKQTMQVAQRLYENGYITYMRTDSTTLSESAIAAARAQVARLYGDNYLPDKPRTYTSKVKNAQEAHEAIRPAGDTFRTPAETGLSGVELRLYELIWKRTIASQMKDAVGESVSVRVAGTSTAGEQVEFSATGKIITFHGFLKAYVEGTDDPQAELDDRERRLPPLTEGDPLHAQSVDAEGHSTRPPARYTEASLVKELEEREIGRPSTYATIIGTILERGYVFKKGSALVPSFLAFAVVQLLERHFSHLVDYDFTARMEDVLDAIARGEAERVPWLRRFYFGADGQIGLKELVNEHLGDIDPKEISSFPLPDSDIVLRVGRYGPYLERNGQRVNVPDDLAPDELTKERAEELFAQPNGDRELGKDPETGRTIVAKNGRFGPYVTEVIEETEAEAEEAKPKGRKKTAAPKPRTASLLKSMSLETITLEDALKLLSLPRVVGEIDGEQVTAQNGRFGPYLKKGSESRSLETEEQLFTVTIEEAKELFAQPKKRRTRAAAPPLRELGPDPVTGKPMVIKEGRFGPYVTDGESNASLRKGDDVESLTPERAAELLAERRAKAPAKKTTSRTTTRKTTKSTAKKA
(229) DNA topoisomerase 1 [Mycobacterium leprae TN]
8
MKGPRGSRSGRNGSPRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAKFKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYELVWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDDGELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIVAKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGPVKRPAKKARKVPAKKAARLAPARGISQSPR
(230) DNA topoisomerase 1 [Mycobacterium leprae TN]
8
MKGPRGSRSGRNGSPRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAKFKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLMQTLKPRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYELVWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTNWLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKTGPYLERLLAGDDGELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIVAKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALKIYAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSITDERAAELLADRRARGPVKRPAKKARKVPAKKAARLAPARGISQSPR
(1535) DNA topoisomerase 1 [Streptosporangium roseum DSM 43021]
8
MPAKNGNAGGTRLVIVESPSKAKTIAGYLGRGYVVESSIGHIRDLPEKADDIPEKYKGESWARLGVNVNSEFEPLYVVNHDKKAQVSKLKQLLKDADELYLATDEDREGEAIAWHLREVLNPKVPVHRMVFHEITPRAIQEAVANPRALNLRLVDAQETRRILDRLYGYEVSPVLWKKVKPRLSAGRVQSVATRLVVERERERLAFTSASYWDLQALFDTGRDEAPREFTATLTGVGGKRVAQGRDFASNGRLKSADVVHLDEQAARALAGRLSGTAYKVNSVERKPYTRKPYAPFRTTTLQQEASRKLGFSAKSTMQVAQRLYENGFITYMRTDSITLSETAVAAARSQAIKLYGAAYVPDKPRAYASKVKNAQEAHEAIRPSGEEFRTPGETGLSGDMFRLYELIWQRTVASQMKDAVGESVTVKVGGTSSSGEQVEFGATGRTITFHGFLKAYVEGADDPSTDRDDSEKRLPNLDEGDRLTAAELNVLSHATKPPARYTEASLIKELEDREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLAFAVVNLLEQHFGHLVDYDFTADMEKVLDDIANDRAERVPELRRFYFGEEGDEGLKEMVTDLGEIDAKEISSFSIRGTDIMIRVGRYGPYLDREGARVNVPEDLAPDELTAERAEELFSRPTGDRELGRDPVTGHMIVAKDGRYGPYVTEVLPEEPPPAEGKKKAKKADAPKPRTGSLLKSMSLDTITVEDALKLLSLPRKLGEIDGQEVTAQNGRFGPYVKKGTDSRSLASEEEMFTVTLEQAKELFAQPKARGRRAAAAPPLRELGEDPVSKKPIVVKEGRFGPYVTDGETNASLRKGDEVEQITTERAAELLADRRARGPAPKRPTRPKAKAKA
(312) DNA topoisomerase 1 [Cellulomonas fimi ATCC 484]
8
MSSGRKLVIVESPAKARTIAGYLGEGYDVEASVGHIRDLPQPSELPADMKKGPFGKFAVDVDNGFVPYYVVDPDKRKKVSELKKLLKDSDELYLATDEDREGEAIAWHLLQELKPKVPVKRMVFHEITREAIQRALQSTRDLDDRLVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVPADYWDVTGTFAVEDATQPAFSARLTGLGGRRVASGRDFDDRGRLRSAEAVQLDEAGAHALVAGLDDAAFAVRSLETKPYTRRPAAPFTTSTLQQEASRKLRMSSRQTMRTAQTLYENGYITYMRTDSPALSSQAIDAARRQASELYGPEYVPDAARVYTSKAKGAQEAHEAIRPAGDHFRTPAQVAREITGDQFRLYELIWKRTVASQMADARGQTASVRIAATATPTGATSVGDAPVEAVFSASGTVITFRGFLAAYEEGRDVSRYEDDAAEGAAAEKGEARLPTMAEGDPLGARDLAADGHRTSPPPRYTEASLVKALEERGIGRPSTYAATISVILDRGYVTARGQALVPSWLAFAVTRLLEENFDRLVDYDFTASMEEDLDLIASGEKERSDWLAQFYFGDPALPGEGEGLRDLVANLGEIDAREVNSIEIGDGITLRVGRYGPYLEDANALGEDGNPRRASVPEDLAPDELTVEKARELLETQPEGDLVLGEDPSTGTTIVAKNGRYGPYVTELLPEPELDPALSAAARKKALAAAPKPRTASLFKSMSLQTITIDDALRLLSLPRVVGVDPESGAEITAQNGRYGPYLKKGTDSRTLASEEALFTTTLEEALAIYAQPKRGRGATATPPLRELGDDPTSGKPIVVKDGRFGAYVTDGETNRTLPRDVTPETITPEQAVTLLAEKRAQGPAKKKAPARRTATRSKAATKK
(1425) DNA topoisomerase 1 [Arthrobacter phenanthrenivorans Sphe3]
8
MPSKAKTGKKLVIVESPAKSKTIAKYLGEGFIVEASIGHIRDLPQPSELPAELKKTSVGKFAVDIEHDFKPYYVVSADKKKKVTELKAALKDADELYLATDGDREGEAIAWHLLEVLKPKVPVYRMTFGEITKEAIQRAMGNLRDVDTALVDAQETRRILDRLYGYEISPVLWRKVARGLSAGRVQSVVTRMVVDRERERMAFKAASYWDLTGQFGSDAGSFKAKLAAVDGAKVASGRDFNDDGVLTSKNVAHLNEELATSLAAGLQDASFTVRSVDTKPYTRRPAAPFTTSTLQQEAGRKLRFSSKSTMQVAQRLYENGYITYMRTDSSALSDEAVTAARRQASELYGPEYIPQSPRVYTGKAANAQEAHEAIRPAGDSFRTPAQVAKQLSGDEFRLYELIWKRTVASQMADAKGSTATIRLGAVAVDGRDAEFSASGTVITFPGFLAAYEEGKDETRGDDDSDEARRLPNVAKGDSLAASEIVAVGHETSPPPRYTEASLTAELEKRGIGRPSTYASTISTIQDRGYVRKQGSALVPSWIAFSVIRLLEQHFSDYVDYEFTADMEGDLDKIANGQAVGASWLRHFYFGEDSDPGLLSIVNNLGEIDAREINSIPITDEITLRVGKFGPYLESSAATVDPKTGEIVESARANVPEDLAPDELTAAKAVELMETAAPEERVLGTDPHTGHTIVAKNGRYGAYVTEIIPEMTEEQIAAQPVEYYKNGKPKPPKKPVKAKPRTGSLFKSMTVESVTLDEALQLMSLPRVLGEDAEGNLITVQNGRFGPYLKKGTDSRSIGSEEEIFTITLEQALEIYSQPKQRGARAAVPPLAEFGPDPVSEKNIVVKEGRFGPYITDGITNITVPRATSLEELTREQAVELLAEKRAKGPVKRTATRKAPAKKKATAKK
(1697) DNA topoisomerase 1 [Arthrobacter aurescens TC1]
8
MPSKAKTGKKLVIVESPAKSKTIAKYLGEGFIVEASIGHIRDLPQPSDLPAELKKTSLGKFAVDIENDFKPYYVVSPDKKKKVAELKAQLKDADALYLATDGDREGEAIAWHLLEVLKPKVPVYRMTFGEITKEAIHRAMDNLRDVDTALVDAQETRRILDRLYGYEISPVLWRKVARGLSAGRVQSVVTRMVVDRERERMAFRAASYWDLTGQFGSDSGSFKAKLAAVDGSKVASGRDFNDNGQLTSSTVVHLNEELATSLAAGLENAEFRVRSVDTKPYTRRPAAPFTTSTLQQEAGRKLRFSSKSTMQVAQRLYENGYITYMRTDSSALSDEALTAARRQASELYGPEYVPQSPRVYANKAANAQEAHEAIRPAGDSFRTPAQVAKQLSGDEFRLYELIWKRTVASQMADAKGSTATIRLGAVAADGRDAEFSASGTVITFPGFLAAYEEGKDESRGDEESDEARRLPNVAKGDSLTASDILAVGHETSPPPRYTEASLTAELEKRGIGRPSTYASTISTIQDRGYVRKQGSALVPSWIAFSVIRLLEQHFTDYVDYEFTADMEGDLDKIANGQAVGAAWLKHFYYGEDADPGLLSIVNNLGEIDAREINSVPIAEGITLRVGKFGPYLESSIPTLDAKTGEVVESARANVPEELAPDELTADKAKELMETAAPEERVLGTDPHTGHTIVAKNGRYGAYVTEIIPEMTEEQLANQPVEYYKNGKPKPPKKPVKAKPRTGSLFKSMTVDTVTLDEALALMSLPRVLGEDADGNPITVQNGRFGPYLKKGTDSRSIGSEEEIFTITLEQALEIYSQPKQRGARASVPPLAEFGPDPVSEKNIVVKEGRFGPYITDGVTNITVPRSTSLEELTRERAVELLAEKRAKGPVKRTTTRKAPAKKATAKK
(1575) DNA topoisomerase 1 [Corynebacterium diphtheriae NCTC 13129]
8
MAAKTGNKRLVIVESATKAKKIAPYLGDDYIVEASVGHIRDLPRGAADVPAKYKKEPWARLGVNTDKGFEPLYVVSPDKKKKVADLKAKLKLVDELFLATDPDREGEAIAWHLLEVLKPKVPVKRMVFNEITKPAILAAAENTRELDDNLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFISADYWDVEAEFDTGKPAQDSNPTSFTGRLTALDGKRVATGRDFNDRGELKGDAVVVDKQRAEALVEELTGVAMSVTKVEEKPYTRRPYAPFMTSTLQQEAGRKLHYTSERTMRIAQRLYENGHITYMRTDSTTLSEQGLKAAREQAISLYGADYVADAPRRYDRKVKNSQEAHEAIRPAGERFATPGDLHGQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTITGNNAEFSATGRTITFPGFLRAYVEVSTLADGRDVADNAESHLPRLAEGDGVETKNLEADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVIGLLEKSFAALVDYDFTSSMEDELDEIAAGHENGAHWLTGFYFGDAEASDAKAESIARHGGLKALVGDNLEQIDARLVNSLPLFKDQEGRDVNVRVGRYGPYLERQVGVSEDGEPEYQRANLSDSTTPDELTLELAEKLFATPQSGRELGRNPKNNRMIVAKEGRFGPYVTELVNDDERTEVEAKAEEIVAAEREAEDLQRAAEGKRAKNWGTKTAAAQKEKRIAQIIEETLKPSTASLFKTMEPSSVTLDEALQLLALPREVGVDPSDNEVITAQNGRYGPYLKKGSDSRTLASEDQIFSITLDEARRIYAEPKRRGRGATSQSVIKQLGDNDVSGKPMSVRDGRFGPYVTDGTTNASLRRGDDPTQLTEARANELLSERRAKEAADGGSSKKATKKASKKTTKRVAKAGARKKK
(1401) DNA topoisomerase 1 [Corynebacterium efficiens YS-314]
8
MAEQQGSRKKSLVIVESATKARKIQPYLGNDYIVEASVGHIRDLPRGAADVPPKYKKEPWARLGVDTEHGFSPLYVVSPDKKKKVADLKAKLKECDELLLATDPDREGEAIAWHLLEVLKPQVPVRRMVFNEITKPAILAAVENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFISADYWDLSAQFRIDSSAQADADNPSTFSARLATIDGQRVAQGRDFNDRGELISDVVVVDKQRAEALAEALQGQEMSVASVEEKPYTRRPYAPFMTSTLQQESGRKLHFTSERTMRIAQRLYENGHITYMRTDSTSLSEQGLKAARAQALELYGSEYVSPTPRTYDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTIAGAATSGEKTEFTATGRTLTFPGFLRAYVETTPTADGRDVADNAEKRLPRLTEGDALTATDITADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGREGRTEWLSGFYFGDAEADDSMAESVARQGGLKALVDQNLEQIDARSVNSLKLFDDEQGRPVFVRVGRYGPYIERVVGTTPEGEPEYQRANLPEETTPDELSLEVAEKLFATPQGGRELGINPANGRMIVAKEGRFGPYVTEQVTEDERAGAEAEAEKVVAAERKAEDEQRAADGMRAKNWETKTAATQKEKRINQLVEETLKPATASLFSGMEPATVTLEEALKLLSLPREVGVDPSDGEMITAQNGRYGPYLKKGTDSRSLSSEEQIFTVTLDEARRIYAEPKRRGRTAAQPPLKTLGDNDVSGKPMTVKDGRFGPYVTDGITNASLRKGDVPESLTDARANELLSERRAKEAADGGAAKKTTKKTTKKTTKKKTTKKTTAKKTTAKKTTAKRAPQTTKRVVKAGSRKQS
(1402) DNA topoisomerase 1 [Corynebacterium efficiens YS-314]
8
MAEQQGSRKKSLVIVESATKARKIQPYLGNDYIVEASVGHIRDLPRGAADVPPKYKKEPWARLGVDTEHGFSPLYVVSPDKKKKVADLKAKLKECDELLLATDPDREGEAIAWHLLEVLKPQVPVRRMVFNEITKPAILAAVENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRVIVERERERMAFISADYWDLSAQFRIDSSAQADADNPSTFSARLATIDGQRVAQGRDFNDRGELISDVVVVDKQRAEALAEALQGQEMSVASVEEKPYTRRPYAPFMTSTLQQESGRKLHFTSERTMRIAQRLYENGHITYMRTDSTSLSEQGLKAARAQALELYGSEYVSPTPRTYDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQMADAKGTSMKVTIAGAATSGEKTEFTATGRTLTFPGFLRAYVETTPTADGRDVADNAEKRLPRLTEGDALTATDITADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGREGRTEWLSGFYFGDAEADDSMAESVARQGGLKALVDQNLEQIDARSVNSLKLFDDEQGRPVFVRVGRYGPYIERVVGTTPEGEPEYQRANLPEETTPDELSLEVAEKLFATPQGGRELGINPANGRMIVAKEGRFGPYVTEQVTEDERAGAEAEAEKVVAAERKAEDEQRAADGMRAKNWETKTAATQKEKRINQLVEETLKPATASLFSGMEPATVTLEEALKLLSLPREVGVDPSDGEMITAQNGRYGPYLKKGTDSRSLSSEEQIFTVTLDEARRIYAEPKRRGRTAAQPPLKTLGDNDVSGKPMTVKDGRFGPYVTDGITNASLRKGDVPESLTDARANELLSERRAKEAADGGAAKKTTKKTTKKTTKKKTTKKTTAKKTTAKKTTAKRAPQTTKRVVKAGSRKQS
(248) DNA topoisomerase 1 [Mycobacterium smegmatis str. MC2 155]
8
MAGGDRGSGGTGNVRRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRNAADVPAKFKSEPWARLGVNVDQNFEPLYIVSPEKKSTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVFHEITEPAIRNAAENPRDLDIALVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERERMAFHSASYWDVTAELDASVSDPSASPPKFTAKLNTVDGRRVATGRDFDSLGQLKRPDEVLVLDEASAGALASGLRGAQLAVTSVEQKPYTRRPYAPFMTSTLQQEAARKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVHPSPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSALDTDEFRLYELIWQRTVASQMADARGTTLSLRIGGSASSGEQVVFNASGRTITFPGFLKAYVESIDELAGGESDDAESRLPNLTQGQRVDAADLSADGHQTSPPARYTEASLIKALEELGIGRPSTYSSIIKTIQDRGYVQKKGSALVPSWVAFAVVGLLEQHFGRLVDYDFTAAMEDELDEIANGQEQRTNWLNNFYFGGEHGVEGSIARAGGLKQLVGGNLEGIDAREVNSIKVFDDSEGRPVYVRVGRNGPYLERMVDDPDNPGEQKPQRANLKEDLTPDELTPELAEKLFATPQEGRSLGIDPETGHEIVAKDGRFGPYVTEVLPEPEDGGDDGTAGTPAKKGKKPTGPKPRTGSLFRSMDLETVTLEDALKLLSLPRVVGVDPTTNEEITAQNGRYGPYLKRGTDSRSLATEDQIFTITLDEALKIYAEPKRRGRQAASAPPLRELGNDPVSGKPMVIKDGRFGPYVTDGETNASLRKGDDVLTITDERASELLADRRARGPVKKKAPAKKAAKKAPAKKAAAKKA
(249) DNA topoisomerase 1 [Mycobacterium smegmatis str. MC2 155]
8
MAGGDRGSGGTGNVRRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRNAADVPAKFKSEPWARLGVNVDQNFEPLYIVSPEKKSTVTELKGLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVFHEITEPAIRNAAENPRDLDIALVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVQRERERMAFHSASYWDVTAELDASVSDPSASPPKFTAKLNTVDGRRVATGRDFDSLGQLKRPDEVLVLDEASAGALASGLRGAQLAVTSVEQKPYTRRPYAPFMTSTLQQEAARKLRFSSERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVHPSPRQYTRKVKNAQEAHEAIRPAGDVFQTPGQLHSALDTDEFRLYELIWQRTVASQMADARGTTLSLRIGGSASSGEQVVFNASGRTITFPGFLKAYVESIDELAGGESDDAESRLPNLTQGQRVDAADLSADGHQTSPPARYTEASLIKALEELGIGRPSTYSSIIKTIQDRGYVQKKGSALVPSWVAFAVVGLLEQHFGRLVDYDFTAAMEDELDEIANGQEQRTNWLNNFYFGGEHGVEGSIARAGGLKQLVGGNLEGIDAREVNSIKVFDDSEGRPVYVRVGRNGPYLERMVDDPDNPGEQKPQRANLKEDLTPDELTPELAEKLFATPQEGRSLGIDPETGHEIVAKDGRFGPYVTEVLPEPEDGGDDGTAGTPAKKGKKPTGPKPRTGSLFRSMDLETVTLEDALKLLSLPRVVGVDPTTNEEITAQNGRYGPYLKRGTDSRSLATEDQIFTITLDEALKIYAEPKRRGRQAASAPPLRELGNDPVSGKPMVIKDGRFGPYVTDGETNASLRKGDDVLTITDERASELLADRRARGPVKKKAPAKKAAKKAPAKKAAAKKA
(1195) DNA topoisomerase 1 [Mycobacterium marinum M]
8
MADPKTKGPGSRSSGGNGSGRRLVIVESPTKARKLAGYLGPRYIVESSRGHIRDLPRAAADVPAKFKSEPWARLGVNVDADFEPLYIISPEKKSAVSELKDLLKDVDELYLATDGDREGEAIAWHLLETLKPRVPVKRMVFHEITEPAILEAAENPRDLDMDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRMIVQRERDRMAFRSASYWDIVATLDASVSDPKAAPPTFVARLTSVDGLRVATGRDFDSLGTLRKADEVTVLDEARAAALATGLHGAQLSVASVEEKPYSRRPYPPFMTSTLQQEAGRKLRFSGERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGEEYVASSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGDEFRLYELIWQRTVASQMADARGTTLSLRIGGSAGEQQVVFSASGRTLTFPGFLKAYVETVDELVGGEADDAERRLPNLTPGQRLDAVELTPDGHTTNPPARYTEASLVKAFEELGIGRPSTYTPIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGHLVDYGFTAAMEDELDAIASGQERRTDWLNNFYFGGDHGVSDSVARAGGLKKLVGVNLEGIDAREVNSIKLFDDEQGRPIYVRVGKNGPYLERTITGEDGEPTPQRANLNDSLTPDELTLVLAEELFATPQEGRVLGIDPESGHEIVAKDGRYGPYVTEILPEPPAPEAGTEAPAKKTKKATGPKPRSGSLLRSMDLQTITLEDALKLLSLPRVVGTDPASGEEITAQNGRYGPYLKRGTDSRSLATEDQIFSITLDEALKIYAEPKRSGRQSASAPPLRELGTDAASGKPMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKRAAKKTTRKSPAKKAVKRA
(776) DNA topoisomerase 1 [Sanguibacter keddieii DSM 10542]
8
MSAGRKLVIVESPAKARTIAGYLGDDYEVEASVGHIRDLPQPSEMPADMKKGPFGKFAVNVDGGFEPYYEVYADKKKKVAELKRALKNADELYLATDEDREGEAIAWHLLQELKPKVPVHRMVFHEITREAINRALENTREIDGRMVDAQETRRILDRLYGYEVSPVLWRKVRQGLSAGRVQSVATRLVVERERERMAFVTANYWDVSGDFTTQDGPDAGEWFSAKLVQVDGARVASGRDFTDAGELKSPQGVVHLDEQAAHALVTALADQPAAVRSLETKPYTRRPAAPFTTSTLQQEASRKLRMSSRQAMRTAQTLYENGYITYMRTDSPSLSTQATDAARRQAAELYGPEYVPSSPRVYASKAKGAQEAHEAIRPAGDSFRTPAQVSREISGDQFKLYELIWKRTVASQMGDARGSTASVRLGVAGTLPAGAPSIGDAGPGSQTDAVFAASGTVITFRGFLAAYEEGRDTDRYDSADSTGTSKKAEGDARLPQMAEGDAMTSRELSADGHSTSAPPRFTEASLVKALEERGIGRPSTYASTISTIQDRGYVLSRGQALVPSWLAFAVIRLLEEHFGQLIDYDFTAEMEADLDAIAAGDKERVAWLTQFYFGDDTEGSDEGLRQLVEDLGDIDAREINSVPIGEGITLRVGRYGPYIEDTAAEVAEGENPPRASVPDEVAPDELTVAKARELLETQGDGDIELGVDPSTQTTIVAKAGRYGPYVTELLPEPEFEEGLSAAALKRAKAALPKPRTASLLKTQSLQTITLDDALQLLSLPRVVGVDPESGTEITAQNGRYGPYLKRGTDSRTLPSEESMFTVTLAEALEIYAQPKRGRGATAAPPLKELGEDPTSQKPIVIKDGRFGAYVTDGTTNRTLPKDITIEAITHEQAVELLAEKRAKGPVKKTTRATAAKKTPAKKTPAKATAAKSTTARSTTTKTATAKKAPAKKAPAKKAAPEA
(1041) DNA topoisomerase 1 [Gordonia bronchialis DSM 43247]
8
MADTSTATPTNGRTLRRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRGAADVPAKYKGQPWARLGVNVDENFEPLYVVSPDKKSTVTELKSLMRDVDELYLATDGDREGEAIAWHLLETLKPKIPVKRMVFHEITEPAIRAAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIIVERERERMAFVSAEYWDIDANMDAGKDASPQTFNARLVGVDDARVATGRDFDSRGALKRADGVVVLDETRARALADALDGADITVSSVEEKPYTRRPYAPFMTSTLQQEAGRKLRFSSDRTMRIAQRLYENGFITYMRTDSTTLSESAINAARAQARELYGDNYVHPTPRQHTRKVKNAQEAHEAIRPAGESFRTPGQVAGQLEADEFRLYELIWQRTVASQMADAKGTTLSLRMTGTASTGETCVFAASGRTITFPGFLSAYVETVDDLAGGQADDAENRLPQLREGQALRATELSADGHSTNPPARFTEASLVKVLEELGIGRPSTYASIIGTIQDRGYVVKKGNALVPSWIAFAVVGLLEAYFQGLVDYDFTASLEDDLDEIASGRENRTRWLTEFYFGDAAPNAEHDAEIAGSEIAKHGGLKKLVGVNLEEIDAREVNSIRLFDDEQGRPVYVRVGRFGPYLERNLSAASAASPDAEPDLQRANLPADITPDELTLALAEKLFSTPQEGRSLGVDPVTGHEIVAKEGRFGPYVTEILPSDDDDDDGNSPATVPAGPTPRDGGGTGGQGSDAEVVPLDTPSGGGTATKTAAKAAAKKTTAKKAAKKAGPKPRTGSLFKTMDISTVTLDDALKLLSLPRVVGVDPESGDEITAQNGRYGPYLKKGTDSRSLTSEEQLFSITLDEALKIYSEPKRRGRQAAAPPLRDLGKEDSVSGKPMVIKDGRFGPYVTDGETNASLRKGDEVATITPERAMELLADRRARGPATKRAKKAPAKKATAAKKTAAKKTAAKKTAAKKTTAKKTTAKKTTAKKTAAKKTTAKKTTDTGE
(299) DNA topoisomerase 1 [Mycobacterium africanum GM041182]
8
MADPKTKGRGSGGNGSGRRLVIVESPTKARKLASYLGSGYIVESSRGHIRDLPRAASDVPAKYKSQPWARLGVNVDADFEPLYIISPEKRSTVSELRGLLKDVDELYLATDGDREGEAIAWHLLETLKPRIPVKRMVFHEITEPAIRAAAEHPRDLDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAKLDASVSDPDAAPPTFSARLTAVAGRRVATGRDFDSLGTLRKGDEVIVLDEGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQEASRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPRQYTRKVKNAQEAHEAIRPAGETFATPDAVRRELDGPNIDDFRLYELIWQRTVASQMADARGMTLSLRITGMSGHQEVVFSATGRTLTFPGFLKAYVETVDELVGGEADDAERRLPHLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPDSVARSGGLKKLVGINLEGIDAREVNSIKLFDDTHGRPIYVRVGKNGPYLERLVAGDTGEPTPQRANLSDSITPDELTLQVAEELFATPQQGRTLGLDPETGHEIVAREGRFGPYVTEILPEPAADAAAAAQGVKKRQKAAGPKPRTGSLLRSMDLQTVTLEDALRLLSLPRVVGVDPASGEEITAQNGRYGPYLKRGNDSRSLVTEDQIFTITLDEALKIYAEPKRRGRQSASAPPLRELGTDPASGKPMVIKDGRFGPYVTDGETNASLRKGDDVASITDERAAELLADRRARGPAKRPARKAARKVPAKKAAKRD
(1320) DNA topoisomerase 1 [Tsukamurella paurometabola DSM 20162]
8
MAARGKAADGDGLQRLVIVESPAKGKKIGDFLGPNYTVRASMGHIRDLPSRDNPLPEADQGKSWSRLGVDVDHDFEAHYVTSASKRSTVSELKSLLKQADELYLATDGDREGEAIAWHLQEVLKPKVPVKRMVFHEITQQAIQAAAQEPRELDMNLVDAQETRRILDRLYGYEVSPVLWRKVNQGLSAGRVQSVATRIIVDRERERIAFRTAGYWDIAAQLDAGAEASPRTFGARLVSVDGDRVATGRDFDAQGQLKKPTGITVLDGTRANALVAGLQGANLAVTSVEEKPYTRKPYAPFMTSTLQQEASRKLRFNTDRTMQIAQRLYEGGYITYMRTDSTTLSETAIAAARDQARQLYGADFVHPTPRQYTRKVKNAQEAHEAIRPAGETFQTPGALASVLNSDEFRLYELIWQRTVASQMADVKGTTLSLRIGGTASSGESVEFAASGRTITFPGFLSAYVETVDEQAGGEADDAESRLPQLTKGQRVTAAELTAADHVTSPPARYTEASLVKTLEELGIGRPSTYASIIKTIQDRGYVVKKGNALVPQWVAFAVIGLLEGHFGGLVDYNFTASMEDDLDEIAGGREGRVDWLTRFYFGDAGDAAAAAADGPGPDSPGLKNLVAANLDAIDAREINSIPLYTDTDGNVVYVRVGRYGPYLERTVAPKDGETEPQVQRANILASMTPDELTEEVAEKLFATPQDGRPLGVDPATGHEIVAKEGRFGPYVTEILPEPETDDDTENLDEAAAKPKRKKKTDAPKPRTGSLLKSMDIETVTLDDALRLLSLPRVVGVDPESKEEITAQNGRYGPYLKKGTDSRSLATEEQMFTVTLEEALKLYAEPKRRGRGAAAAPPLRELGNDPVSGNAMVIKDGRFGPYVTDGETNASLRKGDEVASITDERASELLADRRARGPVKKKATKKAPAKKAPAKKAAAKKAVAKKTTATKTAAKKAPAKKAAPAADETV
(1355) DNA topoisomerase 1 [Segniliparus rotundus DSM 44985]
8
MATVAARRSADGARGSQSDRLRRLVIVESPTKARKLASFLGGEYVVESSRGHIRDLPRGTADIPAKYKSEPWARLGVNVEADFDPLYVVSPEKKATVTELKDKLKDVDELYLATDGDREGEAIAWHLLQTLKPKVPVRRMVFHEITEPAILAAAANPRDLDTDLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRIIVQRERERMAFRSASYWDLSVTVGTEPEFSAKLVELDGLRVASGRDFTPQGEPANPDRVHIVGEAEARALAEALVGAQLDVADVAEKPYSRKPYPPFMTSTLQQEASRKLRFSTDRTMRIAQRLYENGHITYMRTDSVTLSQQATEAARSQAAALFGSDSVPKAPRQYASKAKNAQEAHEAIRPAGDSFVRPEQLAQALDQDELRLYELIWRRTVASQMVDARGTSTSLRLATTTTAGTASARDCVFAASGLVITNPGFLRAYVETVDELAGGEADDAQRHLPQLAKGQQVAAREAAPAEHATSPPARYTEASLVKALEDLGIGRPSTYSSIIDTIQERGYVYKKGAALVPAWVAFAVVGLLEAYFDPLVDYEFTAHMEDELDAIAAGREHRTPWLNRFYYGDENGPVRSVARAGGLKRLVGANAETIDAREVNSIPVFEDSEARQVWVRVGKFGPYLERMVKDDQGELVSQRANLQQGLTPDELTPELAEQLFATPSEGRVLGFDPQSGHEIVVKEGRFGPYVTEVLPPAVVAQQEEKAKAKGGKNAAAPKPRTASLFKSMTPESVTLEDAVRLLSLPRTVGSDPNTGEEITAQNGKFGPYLKRGSDSRSLANEEQLFTVTLDEALALYAEPKRRGAQAAAGPLRELGVDPVSGVPMVVKSGRFGPYVTDGTTNASLRKGDEVESLTDERAAELLAERRAAGPAKKKPAARRTPAKSTTAKRPTTARKTTTKKPTS
(708) DNA topoisomerase 1 [Micromonospora aurantiaca ATCC 27029]
8
MPSNAGTTRLVIVESPAKAKTISGYLGPGYVVEASFGHVRDLPRNAADVPAKYKGEPWARLGVDVDNGFHALYVVSPDRKQQISKLVKLAKEVDEIFLATDEDREGEAIAWHLVETLKPKVPVKRMVFHEITKPAIQAAVANPREIDRDLVDAQEARRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERQRMAFRTAEYWDILATLAVAKPGEGPRTFNATLVALNGDRIATGKDFEPTTGRVRAGAGVVHLDEGGARGLAARLADQPFTVTRVEEKPYRRRPYAPFITSTLQQEAARKMRFSSQQTMRTAQRLYENGYITYMRTDSVNLSETAITAARRQIVELYGERSVPPEPRRYTGKVKNAQEAHEAIRPAGDNFRTPGEVAKELSAEEFKLYELIWRRTIASQMTDAVGSSVSVRIRAVSSAQEEADFGATGKTITDPGFLRAYVESSDDENAEAEDAERRLPTLVKDQPLTADELAAQGHHTQPPARYTEASLVKALEELGIGRPSTYASIMQTIQDRGYVVKRGQAMIPSFLAFAVIGLMERHYPRLIDYDFTASMENELDEIAGGDHAAVDFLTSFYFGSTNGTGDQAIAHAGGLKKLVTENLSEIDARSVNSIPLFTDDEGREVVVRVGRYGPYLQRALPGEQQAPTPAASGEGEESGSQGDRAPIPEGLAPDELTPEKVHELFLGGGGERKLGDDPSTGEPIVLKSGRFGPYVASGERKSSLLRSQTPDSLTLEQALQLLRLPRLIGVAPDGVEVFANNGRYGPYVKRGDEFRSLDSEDKMFTVTLDEALALLAAPKTRQRRAAAPPLREMGNDPLTEKPLVIKDGRFGPYVTDGEFNASLRRGQTPEELTLEQASEMLAEKRAKGPAPKKKAAKKAAPAKKTTAAKKTTAAKKTTAAKKAPAKKAAPKKATSTPNE
(873) DNA topoisomerase 1 [Salinispora arenicola CNS-205]
8
MPSNAGTTRLVIVESPAKAKTISGYLGPGYVVEASFGHVRDLPRNAADVPAKYKGEAWARLGVDVDNGFHALYVVSSDRRQQISKLTKLAREVDEILLATDEDREGEAIAWHLVETLKPKVPVKRMVFHEITKPAIQAAVANPREIDRDLVDAQEARRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRTVVERERQRMAFRTAEYWDILATLAVEQAGEGPRTFNATLVALNGDRIAAGKDFEPTTGRVRPGAGVVHLDESGAHGLAARLAGRPFTVTRVEEKPYRRRPYAPFITSTLQQESARKLRFSSQQTMRTAQRLYENGYITYMRTDSVNLSETAIAAARRQIVELYGERSVPPEPRRYTGKVKNAQEAHEAIRPAGDTFRTPGELRNELSVEEYKLYELIWRRTIASQMTDAVGFSVSVRIRAVTSAGEEADFGATGKTITDPGFLRAYVESSDDENAEAEDAERRLPTLVKDQPLTGEQLVAQGHHTQPPARYTEASLVKALEELGIGRPSTYASIMQTIQDRGYVVKRGQAMIPSFLAFAVVGLMERHYPRLIDYGFTASMENELDEIAGGDHAAVDFLTAFYFGTTNGAGDQDIARSGGLKKLVTENLSDIDARSVNSIPLFTDEQGRVVVVRVGRYGPYLQRELPGEAATPADGEEGGGQGDRAPIPDGLAPDELTPEKVHELFLGGGGERKLGEDPATGEPILLKSGRFGPYVASGERKSSLLRSQSPDALTLEEALRLLSLPRLVGVDPEGNEVFANNGRYGPYVKRGEEFRSLDSEEKMFTVTLDEALALLAAPKTRQRRAPAPPLRELGADPLTEKPLVIKDGRFGPYVTDGETNASLRRGQTPEALSLEQASEMLAEKRAKGPAPRKRAAKKATPAKRSTPAKKAAATKTTATGKATKKTAAATKVAKKTATAKTTTAKQAKPKRASSTTE
(41) DNA topoisomerase 1 [Propionibacterium acnes 6609]
8
MSPTKSLVIVESPHKATMIAGYLGPKYTVRASQGHVRDLPTSASEVPAKYKGEPWARTGVNVDNEFTPVYVVSPEKRSTIRELKSLLKDSDELLLATDGDREGEAIAWHLLDELKPKVPVRRMVFNEITEKAINEAVAHTRKLDTDLVDAQETRRILDRLYGYEVSPVLWKKVLPRLSAGRVQSVATRLVVDRERERMAFTSANYWDMEATLTADLDEFQARLVSLDDTKIVTGRDFDSHGNLISSVRRLDEVAATAIAKALEKAPFTVTKVESKPYTRRPYAPFRTTTLQQEAGRKLGFTSQRTMSVAQNLYEGGYITYMRTDSVALSQEAIHAARNQAAELYGSDHIPDKPRIYASKVKNAQEAHEAIRPAGEHFRTPAETGLTGDEFRLYELVWMRTLASQMADAKGETLSVTIDATPVSPVNLPDGDVTTATFTASGRTITFHGFLRAYVESVDEGASDDAQKRLPQLSKGQDLDPREVTAKGHDTRPPARYTEPSLVAKLEELEIGRPSTYASIIRTITSRDYVFKKGSALVPTWLAFAVTRLLEEHFSNLVDYQFTADMEETLDQIARGNADRVAVLSAFYFGQTKTGDGDVPTPTEGHEGLHQLVTELGDIDARTICTFPLDDSDVVVRVGRYGTYVEDPEGNRANVDDALPPDELTVEAAKELLVSPNGQDRELGLDPHSHRPIVARNGRFGPYVTEVLDDDEATEIVETTTKDGKKRRTKRKVKPRTASLFRSMSLETVTLDEALKLLSLPRVVGTAADGTEITAQNGRYGPYLKKGTDSRSLGSEDEIFSITLEQAEAIYAQPKQRGRAAAKPPLRELGEDPASGRPIVVKDGRFGPYVTDGQTNATLRKDDSVEDITPERAQELLAEKRAKGPAKKSPTKKKTTRKTTTRTTTTKKTTKATSKSVKVTKANAKTSSGS
(1182) DNA topoisomerase 1 [Streptomyces clavuligerus ATCC 27064]
8
MTAPTECRPERRAKLSPTSETAQGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVPEKYTGEVRRLGVDVEHDFQPVYVVNADKKAQVRKLKEQLAESDELYLATDEDREGEAIAWHLLEVLKPKVPVHRMVFHEITKDAIRDAVANPRQLNQRMVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERRAFTSAEYWDLTGTFATGRRGDASDPSSFTARLNTVDGQRVAQGRDFGPDGLLKSGSSAQVLHLDEANARALAAALENTSFTVRSVESKPYRRAPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSETAVAAARAQVTQLYGAGYLPEKPRVYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKRTVASQMKDATGNSVTVRIGGTASDGRDAEFTASGKTITFHGFMKAYVEGADDPNAELDDRERRLPQVTEGDGLTAEEISADGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKKGTALVPSFLSFAVVNLLEKHFGQLVDYDFTAKMEDDLDCIARGEAQAVPWLKRFYFGEGEGGEGTGAAAGRTGDGDHLGGLKALVTDLGAIDAREISSFPVGNGIVLRVGRYGPYIERGEKDTEGHQRADVPDDLAPDELTVGLAEELLAKPSGDFVLGNDPRTGHEIVAKDGRYGPYVTEILPEGTPKTGKNAVKPRTASLFKSMALDTVTLEDALRLMSLPRVVGADAEGVEITAQNGRYGPYLKKGTDSRSLENEDQLFTITLDEALAIYAQPKQRGRAAAKPPLKELGTDPVSERPVVVKDGRFGPYVTDGETNATLRTADSVETITPERGYELLAEKRAKGPAKKTAKKAPAKKAPAKKTAAKTAAKKTTTAAKKTATAKTTAKKTTTAKATTARTAAKKTAAKKAAAAPVAED
(646) DNA topoisomerase 1 [Kitasatospora setae KM-6054]
8
MSPSSETAHGKRLVIVESPAKAKTIKGYLGPGYIVEASVGHIRDLPGTAAEVPDEYTGEVRRLGVDVDHDFAPIYVVNPDKKSQVTKLKSLLKESDELFLATDEDREGEAIAWHLQEVLKPKVPVHRMVFHEITKDAIQEAVRNPRHLNKRLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRLVVERERERIAFTSASYWDLVGTFGTGRTAAGAADPESFGARLVSVDGKRVATGRDFGPDGRLKSAATTLHLDEQAARGLAAALQQTAFSVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKRTMQVAQKLYENGFITYMRTDSTTLSETAITAARAQVTQLYGADYLPSAPRTYASKVKNAQEAHEAIRPSGDRFRTPAETGLGGDDFRLYELIWMRTVASQMKDAVGQSVTVKVGGRAADGRDAEFSASGKIITFHGFLKAYVEGADDPNAELDDRERRLPQVAEGDPLAAERLTPEGHATKPPARYTEASLVKELEDREIGRPSTYASIIDTIINRKYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTAKMEDDLDRIAAGQAESVPWLKRFYFGAGEAGGAVGGAADAGNGDGDHLGGLKELVTDLGAIDAREISSFPVGDGIVLRVGRYGPYVERPAPEGETGQRADVPEDLPPDELTVELAEELFAKPSGERELGTDPVSGNPLVAKAGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFQSMDLDTVTLEDALKLLSLPRVVGADAEGNEITAQNGRYGPYLKRGTDSRSLTSEDQLLSITLEEALAIYAQPKQRGRAAAAAPLKELGNDPVSEKPVVVKDGRFGPYVTDGETNATLRKDDEVETITPERAFELLAEKRARGPVKKAAKKAPAKKAAVKKTAATKTAAKKTAAAKTTAAKKTATVKKTAAKKTAAVKSTAEAAPGGGSEES
(1267) DNA topoisomerase 1 [Thermomonospora curvata DSM 43183]
8
MPAKNGTAQRGRGRGRAAASSGTGTRLVIVESPAKAKTIAGYLGSGYVVESSIGHIRDIPRPADMPEEIKNEPWAKLGVNVDKDFEPYYEVTPDKKSQVAKLRKALKEADELYLATDEDREGEAIAWHLREVLKPKIPVHRMVFNEITPEAIRHAAANPRELDLKLVDAQETRRILDRLYGFEVSPVLWRKIMQGLSAGRVQSVATRLVVERERERIAFVPAHYWDIEADFAVAAADEEGGLRSFVAHLVGVDGKRIAQGRDFSSRGELKSAELLHLDEEAARGLAERLSGRPFTVTSVERKPYTRKPYAPFRTTTLQQEASRKLGFSAKYTMQVAQRLYENGFITYMRTDSTNLSETALAAARAQATALYGPEYVADKPRIYATKVKNAQEAHEAIRPAGDVFRTPAETGLTGDQFRLYELIWKRTIASQMKDAVGQSVSVRVEGSSSAGERAEFAATGKTITFYGFLKAYVEGADDPESDADDSERRLPALAEGDPLSAERLQAQGHSTRPPARYTEATLVKELEEREIGRPSTYATILGTILERGYVFKKGTALVPSFLAFAVVNLLEKHFGHLVDYDFTAKMEDILDLIARGEAERVPWLRRFYFGDGNGEGEVGLKELVTDLGEIDAIGVSTFPIPGSDITARVGRYGPYLVRTKPDGTEERVNIPADLAPDELTAEKAEELFAQPSGDRELGRDPETGHAIVLKTGRFGPYVTEVLPEELTTTASGRKKKDAPKPRTASLLKSMRPETVTLEDALKLLSLPRTLGELDGEPVTVHNGRFGPYVKKGSDSRSLASDEELFTLTLEQARELFAQPKQRGRGRSAASAPLRELGEDPATGKPIVVKEGRFGPYVTDGETNASLRKGDEVESITVQRAAELLAERREKVAAGGGRKTATRRASAKKTATAKKTTAKKTSARSAT
(1293) DNA topoisomerase 1 [Geodermatophilus obscurus DSM 43160]
8
MAPTKTTHTGTRTAAATAGGTSTPARRRTAAGGGRPLVIVESPTKAGKIAGYLGSGYVVEASVGHIRDLPRNAADVPAEHKGASWARLGVDVDNAFEPLYVVSPDRKQQVSRLKQLVKDASEVYLATDEDREGEAIAWHLVDTLKPRVPVRRMVFHEITPEAIARAVANPRELDTALVDAQETRRILDRLYGYEVSPVLWKKVLPKLSAGRVQSVATRIVVERERERMAFHSADYWSLEGTFTVTGRRTSADEGEPTTLRARLVSVDDSRVATGRDFDPATGRATGEVVHLDEAGARGLAARLEGRQVTVSRVDEKPYRRRPYAPFTTSTLQMEAGRKLGWSSAQVMRVAQRLYENGHITYMRTDSTNLSNEAVNAARTQARQLYGDAYVPAEARRYAKKAKGAQEAHEAIRPAGDSFRTPGQLAGQLARDEFRLYELIWQRTIASQMADAVGQSVSIRLAGRSSTDEAVEFTASGRTITFPGFLRAYVESRDEGAAADDDHGSDDAERRLPRVERGQQLDTRELEAKGHSTTPPSRYTEPSLVARLEELGIGRPSTYASIMQTIQDRGYVWKKGSALVPTFVAFAVINLLEQHFAQLVDYDFTASLEQELDEIAAGDLGRVDWLTEFYFGGEGRHAGGIAASGGLKSVIGQRLEEIDARGVNSIPLQATGPNGERVVVRVGRYGPYLQVGGEDGPRVSLPEDLAPDELTQEKVEELLAAPSGDRTLGTDPVSGLPVVVKAGRYGPYVTTVVPEGSKEAPRTASLFSSMSPESVTLDDALKLLTLPRTVGAAPDGEEIQALNGRYGPYLKKGTDSRSLESEDRLFTVTLDEALAVFAQPKQRGRRAAAAPLKELGADPVTQGTVTVREGRFGPYVTDGETNASLRKGDDVESITLERAAELLADRRNNPSTKKATKKKATAKKTTAKKATTTGKTTAKKATKKATAGSDAVPAG
(1606) DNA topoisomerase 1 [Nakamurella multipartita DSM 44233]
8
MATGTSASTRNGGVRLVVVESPSKAKTISGYLGDGYIVESSVGHIRDLPRGAADVPAKYKGEPWARLGVDTEHGFEPLYVVSPEKKAQVAKLKSLLAGADELYLATDEDREGEAIAWHLLETLKPKVPVKRMVFHEITPAAIREAAANPRALDENLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIIVQRERERMAFRSGTYWGLDALMSPAGTGAEPFKSALSTVDGRRLAAGRDFDPATGGLKADADVLLLDEDGARTLATALAGGTATVTSVEEKPYTRKPYPPFMTSTLQQEAGRKLGFNSERTMRTAQRLYENGFITYMRTDSTTLSSSAQEAARAQARELYGPEYVPPTPRQYTRKVKNAQEAHEAIRPAGDNFRTPGQVANQISGDEYRLYELIWQRTIASQMVDARGLTLSVKIAATAREQECVFSASGRTITFPGFLRAYVETVDAEAGGEADDAERRLPKLETGQKLDIRDLIPASHVTTPPARYTEPSLIGALQDLGIGRPSTYTSIIRTIIDRGYVWKKGQALVPSWIAFAVIGLLEQHFSRLVDYNFTAAMEDELDGIADGRIGRTDWLSAFYFGGDLGPAGSVGRSGGLKKLVGERLEDIDAREVNSLPLLTDAEGRQVLVRVGRYGPYLERMVQGEDGEPTAQRANLPEDLPPDEVDAEVAEKLFSQSGDGGETELGVDPDTGHLIVAKDGRFGPYVTEVLPEAAPAATGADGTAKKTTKAKAAAKPRTASLFKSMTLDTIDLPTALRLLSLPRVVGVDPADGQEITAQNGRYGPYLKKGTDSRSLTSEDALFDVTLDEALALYAQPKTRGRSAAAAPPLREVGIDPSGGKPMVIKDGRFGPYVTDGETNASLRKGDEVETLTVERAAELLADRRARGPAPKRATTRKPAAAKAGAAAGGTKTATKTAAAKTTATKTATKTASKTTAAAKARTTKAAGTTRSTTRRTGPAE
(767) DNA topoisomerase 1 [Acidothermus cellulolyticus 11B]
8
MATTAARSGRRSGTPADGATRAASGTRRGPASQGGTRLVIVESPAKARTIAGFLGPGYVVESSVGHIRDLPASAAEIPEKYKKEPWARLGVNVDRNFEPLYVVAADKRKQVTKLKQALAQAEELYLATDEDREGEAIAWHLVEVLKPRVPVRRMVFHEITRQAIEEAARNPREIDQALVDAQETRRILDRLYGYEISPVLWKKVMPALSAGRVQSVATRMVVERERERIAFRPAAYWDVIAEIATTPSFSATLVAIDGKRVAVGRDFDAQGRLKNPDVVHLGEADAQRLVRGLDGAEFVVRSVERKPYRRAPAAPFITSTLQQEASRKLGLSSQATMRIAQRLYEAGYITYMRTDSTTLSETALAAARAQIAELYGDQLLPAAPRRYEKKVKNAQEAHEAIRPAGDRFRTPADLAGELSGDELRLYELIWQRTLASQMIDATGYTVSIRIAAVTDAGREAVFAATGTVITQPGFLRVYVESSDEEDDSGSGRTLPDLTEGETVPVAALTPAEHTTTPPPRYTEASLIRALEERGIGRPSTFASIVSTIIERDYVFKRGQALVPTFLAFAVVRLLEKHFGNLVDYDFTAEMEENLDRIANGEAHRLEWLTRFYFGSPTDGGSAAGLKQLVTERLAEIDARDISTFPLGESGIVVRVGRYGTYVERDGQRASLPPGTAPDEVTVEFATRLLEQPTGERELGVDPATGHTIVARVGRYGPYVTEVLPEGAKGKPRTASLLSSMTVESITLDDALKLLSLPRVLGEVDGEQVIVSNGRFGPFVKKGAETRSLGSEEELFTLTLDEALQLLAQPKQRGRRLPAAAAQVRELGVDPATGRTVTARTGRYGPYVTDGETNATLRHGDTLENVTLERASELLADRRSRGPTTPRPRRGRRAAVRSE
(1835) DNA topoisomerase 1 [Catenulispora acidiphila DSM 44928]
8
MAGKGSADSRGSTRRLVIVESPAKAKTIKGYLGAGYTVEASVGHIRDLPAGADEVPEKYKGTSMGRLGVDVDGDFEPLYLVNADKRKQVAKLKDLLKEADELLLATDEDREGEAIAWHLQEVLKPKVPSKRMVFHEITREAIQQAVSNTRDINLQLVDAQETRRILDRLYGYEVSPVLWKKVRTGLSAGRVQSVATRMVVDRERERIAFTAAEYWDLTGSFETLKAPAPGDPRGMTARLASVDGKRVASGRDFGPDGQLKSGSQNVAHLTEVTAKALAAALRDADFSVRGVERKPYRRSPYAPFRTTTLQQEASRKLGMDSKRTMRVAQSLYENGYITYMRTDSITLSDTALNASRTQVRELYGADYLPDVPRRYDSKVKNAQEAHEAIRPSGDTFRTPAQTGLKGDEFRLYELIWMRTVASQMKDATGHTVTVKVGGAASDGRDVEFSASGRIISFHGFLKAYVEGTDDPDAALDDSEQRLPAVAEGDALTTTKVTADGHSTKPPARFTEASLIKEMEEREIGRPSTYSTILGTILDRGYAFKKGTALVPSYIAFAVVGLLENHFGDLVNYEFTARMEDDLDRIARGEAQRVPWLRRFYFGPTGEEPGAAPAALKSGGGDGAVFDHLGGLKDLVTDLGNIDAREVNSFPVGEDGIILRVGRFGPYIERNLEDGTQQRASVPDDLPPDELTPAFAEELFLQPSGDRELGKDPSTGFEVVAKAGRFGPYVTEILPEGTPTRGKNAVKARTGSLFKNMGLDTVTLEEALQLLSLPRVVGADPESGEEITVQNGRYGPYLKKGADSRSITSEEQIFTITLEEALEIYKQPKARGRGAAKPPLREMGPDPVSGKPIVIKSGFYGEYLTDGETNVTIPKSETVEDITPARAYELLAEKRAKGPAKKTAKKAPAKKTAAKKTAASSGTKTAKATAAKKTAAKKTANSGTK
(393) DNA topoisomerase [Bifidobacterium breve UCC2003]
7
MRRNDVDLLVNACDPDREGEAIFRRIIHHAGVNKPTRRLWVASLEEEAIRQALAAMKPEGDYRGLADSAMIRAKADWLIDMNASRAYSLVYNTRFTVGRVQTPTLAMIVERDRQIESHKPTPFWKVVAPMGSWTLTGTHLENHGTAEALLEIVNQPDFAFGIYAVKRHRQHDAPPRLYDLTNLQKDMSKLHGLTAAHTLTALQSLYEQRLTTYPRTDSRFITHDDLDALRKLTNGDRLASGFLDPAVRPAQPRLELTVNDAKVTGHTAILPTLQASGETLGQLGDDKRLVLTRVVRRMWEAVADDHVHDVTLVVANIDPDYDESHPNLLRISEADSRFTSCSDQTISLGWKGIEPTKTQEHDGGEDEEDAPAGNLIPVNLATGANAMPMPRSGARLVEGKIKPPKPYTEATLLAAMEHASRLLDDAGLKAALDDDESHSGGIGMPATRADVIEKLIRSAYVERKGKQLRSTEQGRNLINVVALRLKDVALTAEMEQVLSDVEHGNADPTQTESRFRAFAAGIPADAQSTAEPELVQARRSRVTESFGPCPRCGQPVVKTGKVWQCSTNKREKQPDGTWKDAGGCGWKLFSTIAGKTLTDANARRFLADGRIRLKGFISKAGRKFDAMLILDKEGGARFKFNDK
(158) DNA topoisomerase 1 [Bifidobacterium breve UCC2003]
8
MATKLVIVESPTKAHKIGDYLGKGYTVMASVGHIRDLAQPSQVPAADKPKFGKFGVDVNDGFKPYYIVDGDKKRTVSELKSALKGADELYLATDEDREGEAIAWHLVQTLKPKVPVKRMVFHEITKDAINASLSKTRDVDSHMVDAQETRRILDRLYGYELSPVLWRKVGPGLSAGRVQSVATRLIVERERERMAFKRAPYWDVVATLAASDALGERTEFAARMISLGGKRLAGSKDFGSDGQLTPDGFAGSVRQLDEASATAVAEALKNADFTVMSMETKPYRRRPQPPFTTSTLQQTAGNRLGMGSRAVMRAAQSLYENGYITYMRTDSVTLSQEAITAARNAVSYHFGDKFLSAEPKQYATKTAGAQEAHECIRPAGSRFHDPDELASKLPIDQLRLYTLIWQRTLACQMADATGSTATVRLSAPAGPADGEAVFQASGTVIEFPGFMKATGEGRKPKPAAADAAAADKSGAKATKSDASESNASLPPMEVGQRVEASDIEPDGHETQPPARYTEATLVKTLEAKEIGRPSTYASIISTIMDRGYVYERGRALIPSWLAFSVTKLLETNFPKLVDYTFTAEMENGLDRIAHGEETGRDWLTHFYFGSGEGAARNADEAHEGLQQQVAQLGEIDARAINTIDIGDGLHVRVGRYGPYLEDMEHLDAEGNPKRASLPDTIAPDELTVEVAHDLTDNHSGGPRELGKDPVSGGTVEVRNGRFGPYVALVPPEGAADSAATAPAGKKSSKKAAAAASRPRMASLFKTMSPESLSLEDALKLLSLPREVGKYEETNAETGEVSECTVAANNGRYGPYLTKTSADGRSDTRSLGSEDEIFTVDIDKAKELFAQPKYGRGRGRGAAKPPLRDLGNDPNTGKHVTIKDGRFGAYITDGETNRTVPRQYTPESIAPEDAFRLLAEKRAAGPSTRGRRGRERAGAAKSGARGAKKGAASAATNAAEAKRAGRRAEVKKLANKGWSNQRIAEKLSSTAATVKKDVDWLTANEGYERPAVIPKRG
(1080) Topoisomerase IA [Slackia heliotrinireducens DSM 20476]
3
MKLVVTEKNNAAQRIAELLGVKKPKSDKVYNTPVYRFERDGEEWVSIGLRGHILEPDFVPTITYKRNKGWLATPDDGASYKVDIPSFLPKPPFKTKRKPFLADGVAIGGSWKMDALPYLVYAPIQKNPKEKDIIRSLKNLAKKADDIIIATDFDREGELIGSDALSCIREVNTTAPVSRARYSALIKPEITHAFENLVELDMNLAHAGESRQEIDLIWGAVLTRYLTIVKFAGYGNVRSSGRVQTPTLALIVERERERMAFVPEDYWVIKAKFSDGIEPFEATHKEGRFKTQEAADAVMNAVNGAQFGTVSGIEKRKRTVSAPTPFNTTGLMAAAAAEGLSPARTMRLAESLYMAGYTSYPRVDNTVYPSSFDLPAMVKTLSEVPAYEPYCRQLLAKGTLTPTRGKQESTDHPPIVPMQAASPDKLQPAEWKLYNLIARRFLATLSDAAVIEGTKVSVDVNDETFITRGDVVVKPGFRAIYPYGAKKDTILPQLNEGQQVDFLGATCEQKQTEPPARYSQGKLIQEMEKLGLGTKATRHSIIDRLYNVKYIQNDPIEPSQLGIAVCDALGRFAPQITSPGMTAELEKDMNQIADGDKTQKEVVDLSRDILNDVLKELMPHSEEVASALGDAVAADAYVGTCPKCGKDLQMRASNKTKSMFIGCSGWPECDVTYPLPKGKVEVVEEKCPVCGMPQIKVTAFRSKPRVQCIDPNCDSNQEPDVIVGACKACAEKGLDKKLIAQRNPRTLKRFIRCENYEECGVSYPLPQHGELKATEEVCPDCGAPMVIVTTGRGPWKLCPNFDCPGKEKEEGAEDKKAPAKRTTRKTATKKTTRKTSK
(675) Topoisomerase IA [Cryptobacterium curtum DSM 15641]
3
MKLIVTEKNDAAEKISELLGAGRPKKDKVYSTPVYRFTHQGEEWVTIGLRGHILEVDFAQRLVWSKRAGWRGVGATGEALDAEVPADLPTPPFKKKKPFSEDGVDLKAWKMEALPYLTYAPIEKLPKEKDIIRSLKNLAKKADSVVIATDFDREGELIGSDALSQIHEANPLLPVSRARYSAFTKQEITTAFDNLVQLDGNLAQAGASRQDIDLIWGAVLTRYLTTVKFAGYGNVRSSGRVQTPTLALIVEKERERLAFVPEDYWQIRGAFAVGDESFTAPHATARFKVEAEARSAMDRVQNAHSATVSAIEKKTRRVAAPAPFNTTSLMAAAAAEGIRPARCMRMAESLYMDGFISYPRVDNTVYPASLDLAEVVHMLEGNPAYRPYCAQLLSQGPLHATRGKKEETDHPPIYPTNVATPDTLPAAEFKLYNLIARRFLATLSDAALIEGTKVSLDVAGEPFTAKGDVLKEAGFRAIYPYGLKKDEQLPTLNQGEQISFEGATLEQKQTEPPARYSQGRLIQEMEKRGLGTKSTRHSIIERLYTVKYIQNDPIEPSALGMAVCDALGQWAPHITTADMTAELDREMDAIAAGRKTREDVVTHSRDLLSEQLSELIPHSEQVKDALADAVAADAYVGKCPRCGKDLQLRVSQKTRSMFIGCAGWPDCEVTYPLPKGRIEATDTPCPVCGMPQVKVSPFRAKPYLHCIDPQCASNQEPELVVGKCPTCKANGIDANLVARKNPRTLKRSITCENFDECETRYPLPQYGTLEATDEVCEHCGAPMVTVVTNRGPWKLCPNFNCPGKVEAETAQKAASSQSRRSGSRRSRAKATKGK
(81) DNA topoisomerase I [Olsenella uli DSM 7084]
3
MKLVVTEKNDAAQQIARLLSTVGKPKADKVYDTPVYRFTREGEEWVTIGLRGHIMAPDFPSELHYSKREGWFAVSEGGEVLPAQIPDTLLRPPYESKRKPFLKDGIDIKGWKVPSLPYLVWAPIEKLPAERGIIRALKNLAKKADSIVIGTDFDREGELIGSDALRQMRQVAPDVPVSRARYSAFTKAEIDHAFANLVDLDQDLADAGESRQYIDLIWGAVLTRYLTMARFGGFGNVRSAGRVQTPTLALVVEKERERQAFVPEDYWVLSGMLAPAGTADEDARFKATHTTARFKDQAAAQAAWSHVRDARTATVTAVEKRSRTTRPPAPFNTTSLQTAAASEGISPARTMRLAESLYMDGLISYPRVDNTVYPKSLDLRGCVRMLSQVPQYRAACRELLDAGPLHATRGKQETTDHPPIYPTAAADPGKLEGAAWKLYNLIARRFLATLSQASVSEGTKVAFDVSGEPFSASGTVLVKPGFRAIYPYGLRKDEQLPPLEVGDSCDVVSMALDAKQTEPPARYSQGRLIQEMEKRNLGTKSTRASIIQRLYDVKYLKNDPVEPSQLGMAVIDALTQYAPHITSAGMTAQLEDDMTKVAEGTDTQDEVVTHSRSLLASMMDALIEHKDDLGDAIADAVTADAKVGVCPKCGKDLVMKTSAKNRSSFVGCMGWPDCDVTYPVPKGRISPIEGEGGVCPECGAPRVKVQPFRQRAYETCINAACPTNREPDVVVGECAVCKAAGNHGDLVAHKSERTGRRFIRCTNYDVCNTSYPLPQRGEIHATGKVCEHCGAPLVEVITQRGPWRICVNMDCPGKEKKSARGTRKAGGAKAAGGKGASRG
(745) DNA topoisomerase 1 [Renibacterium salmoninarum ATCC 33209]
8
MPTKASSKRALTGKKLVIVESPAKGKTISGYLGEGFEVEASYGHIRDLPQPSDLPAELKKSSVGKFAVDLDNNFEPYYVVPGDKKKRVAELKAALKDADELYLATDGDREGEAIAWHLLEVLKPKVPVYRLTFPEITKEAIQRAMGELRDVDMPMVDAQETRRVLDRLYGYEISPVLWRKVSRGLSAGRVQSVATRLVVERERERMAFRSASYWDLSGEFTPENSAQAFKAKLVALDGARVATGRDFNDTGVLTSKNVAHLDEAIAAALAAGLQQAKFAVRSVENKPYTRRPAAPFTTSTLQQEAARKLWFSARVTMRVAQSLYENGYITYMRTDSTALSSQAVNAARRQAAELYDPSFVPDAPRVYAGKAKNAQEAHEAIRPAGDSFRIPAQVAKALSSDEFKLYELIWKRTVASQMADAKGSTASVRLGAVATGGQNAEFSASGTVITFQGFLAAYEEGRDEGRNKDDADSDGGRLPNLAAQDALTATEIEPLGHETSPPPRYTEASLVKTLEERGIGRPSTYAATISTIMDRGYVSQRGSALVPSWVAFSVVRLLEQYFQNYVDYDFTAGMEEDLDRISRGEETGPHWLKLFYFGDEDGSGLLPIVNNLGEIDAREINSVPISDGITLRVGKFGPYLEKPVPADAPEGTEPERANVPEDLAPDELTAEKAIELINTAAPEERVLGVDPISGHSVVAKNGRYGAYVTELIPEPTAEDLANAPVEYYKNGKPKPAKKPVKAKPRTGSLFASMSVENVSLDEALQLMSLPRVLGADAEGNEITVQNGRFGPYLKKGSDSRSIGSEEEIFTITLEQALEIYSQPKQRGARAAVPPLAEFGDDPTSGKKIVVKEGRFGPYITDGETNITVPRSTSIEELTRERAVELLADKRAKGPVKRPAKRPAAKAKAGSRR
(495) DNA topoisomerase 1 [Saccharopolyspora erythraea NRRL 2338]
8
MVIVESPAKARKIASYLGSNFVVESSRGHIRDLPSGAADVPAKYKGQPWARLGVDVDNDFEPLYLVTPDKKATVTELKDALKEVDELYLATDGDREGEAIAWHLMETLKPKVPVRRMVFHEITESAIQSAAANPRELDRDLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERERIKFVPAEYWDISATMDAGPDAEPRRFGARLVSVDGAKLATGRDFGPDGRLKNDDVRLLNEAEARRLATGLTDARLSVSSVEEKPYTRKPYAPFMTSTLQQEASRKLRFSADRTMRTAQRLYENGYITYMRTDSTTLSETAITAARNQARDLYGDEYLSPQPRQYNRKVKNAQEAHEAIRPAGESFRTPGQVAAELDTDGYKLYELIWQRTIASQMADAKGTTLSVRITGTSADGEECTFAASGRTITFAGFLKAYVEAVDSEAGGVADDAESRLPRLAQYQAVTAPELSPDGHSTNPPPRYTEASLVKALEELGIGRPSTYASIISTVQDRGYVWKKGSALVPSWVAFAVVGLMEKHFGRLVDYDFTAALEDELDRIAEGRQQRTKWLSGFYFGGEVGPDDSIGRAGGLKKLVGSSVEEIDAREVNSIPMFTDDDGRTVYVRVGRYGPYLERPLSDSESQRANLPDDLPPDELDIQIAEKLFATPMEGRSLGTDPETGHEVLAKEGRFGPYVTEVLPEGSKGKPRTGSLLKSMSLDTVTIDDALKLLALPRVVGTDPESGTEITAQNGRFGPYLKRGSDSRSLDTEEQIFTVTLEEALKLYAQPKQRGRRAAAAPLRELGDDPDSGKPLVIKDGRFGPYVTDGETNASLRKGDSVEELTIDRAVELIAERRAKAPAKKKTASKSKSTASKSTSSKTTASKSSSSKSSSSNGSKTTKSGTTRKRTTSSSKQS
(433) DNA topoisomerase 1 [Thermobispora bispora DSM 43833]
8
MPASNGKAGGTRLVIVESPAKAKTIAGYLGRGYIVESSIGHIRDLPERAEDIPEKYRGEPWARLGVNVDHDFEPLYVVNPDKKAQVTKLKQLLKEADELYLATDEDREGEAIAWHLREVLKPKIPVRRMVFHEITPTAIREAVANPRDLNLRLVDAQETRRILDRLYGYEVSPVLWKKVKPRLSAGRVQSVATRLVVERERERMAFTPAEYWDLQAVFDTGRAADEPRTFSAALTTVDGRRIAQGRDFTSSGTLKSTDVLHLDEAAAAALVRRLDGATYRVKSVERRPYTRKPYAPFRTTTLQQEASRKLGFSAKYTMQVAQRLYENGFITYMRTDSVTLSETAIAAARRQALKLYGPAYVSEEPRVYTSKVKNAQEAHEAIRPAGEEFRTPGETGLTGDEFRLYELIWQRTVASQMKDAVGESVTVRVEGTSAGADPVTVEFTATGRTITFHGFLKAYVEDADDPGTDRDDQEKRLPVLNEGDRLTAQELNALGHSTKPPARYTEASLVKELEEREIGRPSTYATIIGTILERGYVFKKGNALVPSFLAFAVVNLLEQHFGNLVDYEFTARMEECLDAIARGETERVPWLRRFYFGEDQDQGLKGMVNDLGDIDAKEICSFPIKGSDIVVRVGRYGPYLERGDVRVNIPEDLAPDELTAEKAEELFSRPSGERELGIDPETGRMIVVKEGRFGPYVTEIIPEEETAAEGKKRGKKADQPKPRTSSLFKSMSFETVTLEDALKLLNLPRVLGEIDGEVVTAQNGRFGPYLKKGAESRSLASEEELFTVTLEQARELFAQPKTRGRGRAASAPLRELGVDPNTNRPIVVKDGRFGPYVTDGETNASLRKGDTVEEITLERAVELLADRRERAAAQKSGAAGGTKATKKKAAT
(948) DNA topoisomerase 1 [Arcanobacterium haemolyticum DSM 20595]
8
MTKLVIVESPAKARTIANYLGDDYDVTASIGHIRDLPKPSDLPSDMKKGPFGKFAVDVEHNFEPYYVVNPDKKKKVSELRAAMKKADELWLATDEDREGEAIAWHLLEVLKPKIPVKRMVFHEITKEAIQRALEATRDVDTKLVDAQETRRILDRLVGYEVSPLLWRKVAPSLSAGRVQSVTTRLIVERERERMAFVPAGYWDVLVDLRKDGDDFSAKLLELDGSRIAVGKDFDDDGALTPKAAKEGVRVLGADDAQAISETLRDGNSTVVRVETKPYRRRPAAPFTTSTLQQEASRKLHMNSRDTMRVAQALYENGFITYMRTDSVNLSAQAVAAARSQIEDMYGARSLPDKPRVYSTKSKGAQEAHEAIRPAGDSFRTPAQVSGLLRGREFDLYELIWKRTVASQMADAIGSTASVRLSAPVAGFGDALLGASGTIITFPGFMAAYEEGKDKKRYEDQAESRLPDLVEGEKVENTGSKAAGHETAPPPRYTEASLVKTLEEKGIGRPSTYAATISTITDRGYVDRKGQALVPTWLAFAVIRLLEENLPDLVDYDFTADMEEDLDKIAAGQEDPVEYLGGFYRGAGEKKGLRDQVDGLGDIDARAVNTIDIGDGIAVRVGRFGPYLEETKDDGTQGKRASVPPEVAPDELTVAKAHEILDAALDEDRVLGKNEKGWDIVVKDGRFGPYVSEVVPDDAVQLTPTGKVSKVKPKPATASLFASMNPETVTIDDALKLLSLPREIGKSGDDVITVQNGRFGPYMKKGSDSRSLESEEQIFTITLEEAEAIFAQPKQRGKRQAQPPLAELGTDPVSGGKILLKDGRFGLYVTDGETNASLPRSEDPNQITPERAQDLLVQRRLKIAEQGGPKKRNATKKTVSGAGKKKAAAKKTTAKKTAAKKTTAKKTASKKTTTKSATKD
Family distribution
Taxonomy tree
Actinobacteria