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Taxon : Clostridia
Informations
Name
Clostridia
Rank
class
# topoisomerases
195
Lineage and sub-taxa
Lineage
Bacteria
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Firmicutes
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Clostridia
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(469) DNA topoisomerase [Desulfitobacterium hafniense DCB-2]
7
MGKTLIIAEKPSQAREYAKTLGVKGKREGYFENDEYIISWCIGHLFELKAPENYMDLPKVGKRWSIRRLPVLPRLGEFQYGLKSGTAKQFKVLQGLLRSPEVQQVICGTDADREGQLLFQEVWDAVGSKKPLFRLWISSLTQEAIREGMSKLRPVGEVEGLAQAGYGRSYGDWDFGMNLTEGFTALFGSFDPVRKKPNVISIGRVQTPTLALVVEQEWAIENFVPVAYVEVEAEFASGQGSYKGKWFDPAVKNTRDKNQETDNAQMMLDLDRGKEIVAKVQGKPGRIRSVKDKETKEPHPLLFDLTSLTVSASKRYGFGAEKVLKIAQSLYEKKAITYPRTDCNYLPPDMLPKLKVHLQALEQSPFASWVKEALDNPLPGGKRVINEITAHHAIIPTTEKMIPNLSPDERKIWEMIVLRFLCIWFPPARYAEKEVVTVVEEEFFLTKGKTLLESGWKKIENTEKYTEGSGLQLPLLQQNEEVVTRSCQALQKETKPPKRYTQGDLIKAMEGAGKEIEDETLRRQLKGKGLGTVATRGAIIENLLDRGYLLQQQKVLVPTAKGTELIRLIKERLPRAQLLISAEMTGQMEYELAQVERGELPLSRYMEKVEEAIRGIIEELRHYEATRGKKPLAFAPQKAGASGRKSKSNLEEKPQELPVQAKVTKAAKTRQESPASAAEENLGICPSCGGGVVEREKGYGCQNWKNGCPFILWKNPICGKVLTPAQVKSLLKKGKTNLIKGFRSKNGSVFAAYLVWEDPSSGKLKFEFENNDRAKPG
(616) DNA topoisomerase 1 [Desulfitobacterium hafniense DCB-2]
1
MAKTLVIVESPAKAKSISKFLSNNYTVKASMGHLRDLPKSQMGVDVDNDFEPKYIAIRGRGDLIKELRAAAKTANKILLASDPDREGEAIAWHLGHLLGLDLAEKCRIEFHEITKPAITAAIKHPRQIDSSKVDAQQARRVLDRLVGYQLSPFLWRKVKKGLSAGRVQSVAVRLICDREEEIREFIPEEYWTLTASLKSEGGVFSAKLARKGEHRIAIASEEEMQKVLQELADQTYRVKDVRTKEKKKQPSPPFTTSSLQQEAHRKLNMSPKRTMMLAQQLYEGIELGKAGGIGLITYMRTDSVRISETAQEEAKEFIAEHYGADYYPPEPRQFKSKGRAQEAHEAIRPTSILRTPDSVKEFLSRDQLRLYRLVWERFLASQMSAAVLDTLTVEVEAGEYLFRANASTVRFPGYLAVYEDGQDENDDQEEGTLAANIQPDESLNVLQLQEKQHFTEPPPKYTEASLVRKMEEEGIGRPSTYAPTIETIQSRGYVAKEGKQLSPTELGEIVVSILKEYFPEIVDLEFTANMEKRLDDIEEGALPWKAVIRDFYGPFAESIEEADQVMGKVQIEDKVSEEICENCGRNMVIKMGRYGKFLACPGFPECRNTKPLLEEVGRPCPDCGNPLVIRRSKKGRKFYGCSTYPECEFVSWELPAPEPCPKCGGLMVVKTSKQGQKYVCTNSECRFDKQVEEQAE
(1667) DNA topoisomerase 3 [Desulfitobacterium hafniense DCB-2]
2
MGKSLVLTEKPSVGRDIAKLLGCNQKGNGCFIGSRYIVTWALGHLVTLADPEAYGEKYKQWRLEDLPMLPKDMELVVIKETSKQYAAVKQLLRQPDVEELIIATDAGREGELVARWIIGKAGWKKPIKRLWISSQTDKAIREGFNNLKPGKAYESLYAAAECRAQADWYVGLNVTRALTCKYNAQLSAGRVQTPTLALVVEREKEIQNFVPKGYWTINARVQGFSLSWQDKGNGQNRMFDQRKAEQLVQKLRGHKGQVAEIKKEAKREQPPQAYDLTELQRDANRKYGFSAKQTSSIMQQLYEQHKLVTYPRTDSRYLSEDIVPTLPERLKTIAVGPYSELARRVLRTKITPTKRLVDNSKVTDHHAIIPTEQTVFLNKLSPEEAKIYDLIVRRFIAVLSPAFEYEQTTVKVEIQGELFTAKGKIVKQKGWRSVYEGREAADEEADHEEQEQNLPDLQPKQTLEVLDLKLLPGKTKPPKRYTEATLLSAMEHPGQRVNDEALRETLEKTSGLGTPATRADIIEKLFSSFYMERNGKEIVPTSKGIQLIGLVPSELKSPELTAKWEQQLSEISKGREDRQRFIQGIKSYATQLVSEVSGSGRTYRHDNMTRAKCPECGKFLLQVKGKRGEMLVCQDRECGYRQGLSVQSNARCPQCHKKMKLQGEGEHKIFTCACGYREKLSAFNKRREQEGSKGSYNKREVNHYLQKQEKDAPLNTALADALAKLNLPK
(276) Reverse gyrase [Caldicellulosiruptor saccharolyticus DSM 8903]
6
MATGAKYYHSCINCGGINSDTRNQKGLPCEKCLPFENNMNILESLKEHNSLKDYAYFWNFQNEYKEFEKFFVSKVGKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWMAKNGKKVALIFPTVSLVEQTHQRLLEFANKEPKENVKILSYKSSMKRTEKDEFEKNFENGEFDILIVSSQFISKRKDDLAKKVFSLVFVDDVDAILKSSKNIDTLLQMIGIDQKTIDKTFENLKKGVKYPEQKQNGTSSTPSKGILIVSSATAKPQGLKPLLFRELLGFEIGRFTFSVRNITNIRIAGKSKVKLLETIKILNDGILLFVENEEEGKDVTNFLENEGISVGKTWEDFEKSFEEFKDGKLKILCGIYSYYGKLVRGIDLPLRIKYSIFWGTPSFRFSTDIEKAPRFVLERVFSDYLEEHPKLKSFFKNIDKYQVERLREVVKKYIPQDRWTDFIKKSFSNLKISDEGQIFFPDVFTYIQGSGRTSRMLGSSLTKGVSILFEDDDLLFESLRSRLMFLLDEEWKTEDEVCFEDLIKEVEMSRNEALIDERSSDLKSRLMIVESPTKAETISRFLEKASTRRYGRLSVYESVTPDGILLITASKGHVYDLDTKTGVHGVEISNGNFIPYYNSIKRCTSCGTQFTDEYSSCPKCGSDKIDDKKEILKVLREIAAEVDEILVATDPDVEGEKISWDISQYLKPVNPNLRRIEMHEITKFGFESAIKNQRDFNANLVKSQIVRRIEDRWVGFELSSKLQKNFQSYNLSAGRVQSTILGWIIEREKEYAKSQKEFTFVRFENGFGFEAEGKIDGDKVLVDVVEENEKELETILPFNTPTLLSYASQKLNLSVQEIMEILQFLFEHGFITYHRTDSNRISLTGQNMARLYLEKIGKKDLFVGRSFGSEGAHEAIRPVKPISPLELKELSSERLAQGLTANHIKVYELIFNRFFTSQMKNPLVRYQKLIFRFDKQEIEKEMPIEVIEEGWLLFSPIQIFSKFESGEYQIIEKKNYKKHTTPLFTQAMLIDEMKQKNIGRPSTYAKMVEILFKRGYVFEDQYRRIRSTALGRKVYSYLAQHYQDYINEETTRDLERLMEVVEIGEKDYQSVLSSLYEELTKIMQR
(1148) DNA topoisomerase 1 [Caldicellulosiruptor saccharolyticus DSM 8903]
1
MKKLVIVESPAKARTIAKFLGKEFKVEASMGHIRDLPKSDLGVDVENNFAPKYINIRGKADVINRLKKSAQEAEKVYLATDPDREGEAISWHLAIILGLDQNDKVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIEKFKPEEYWTLEAVFKKDNQEFKAKFYGSKKGKLELKNQEQVDKIINQIKDKNFKVTKLKISEKKKNPPPPFITSTLQQEASRKLRFTPAKTMMIAQMLYEGVEIKGEGSVGLITYMRTDSTRVAEEAQEAARRIILQRFGKEYVPEKPRVYKTKKDAQDAHEAIRPTYIEKDPESIKDSLTPDQYRLYKLIYDRFLASQMESSIYDSLSAELEVEGYVFKLTGSKLKFAGFMEVYVEGKDTDEEEEENQLPEIFEGEMLKPIKLEKKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKVVTNILKEYFKDIIDIEFTAELEENLDRIEEGKADWVEIVRKFYLPLEKELETARNTMQQIKVDDEETDVVCENCGRKMVIKKGRYGRFLACPGYPECKNTKPYFDYLDVLCPKCGKKLIEKKSKKGKKYFTCESYPECNFIVWERPAKNCPKCNQLMFEKGKKRSKKLVCSNESCGYEEKIVEKGE
(1123) DNA topoisomerase [Clostridium phytofermentans ISDg]
7
MKVGKFMGKSLYISEKPSVAQEFAKALKSNFRKSDGYMESEDSIVTWCVGHLVTMSYPESYDPALKKWSLQTIPFLPKEFKYEVIPSVSKQFQVVKGLLNRSDVDKIYVCTDSGREGEYIYRLVDQMAKVPKNKEKRRVWIDSQTEEEILRGIREAKPLSDYDNLSSSAYLRAQEDYLMGINFSRVLSLKYGYTVNNFLKNEKHSAIAVGRVMTCVLGMVVRREREIREFVKTPFYRVMLTLETSDRTFDGEFKAVEGSKYYLSPLLYKENGFREKQEAEKLITMLTGYESEYETRIENNNKNSYLAKLKQDEESKQLVAEIVSMEKKKENKNPPLLFNLAELQNECSKLFKISPDETLKYTQELYEKKLVTYPRTDARVLSTAVSKEIYKNIKGLTALSQFQPFAEEVLALGSYKNIAKTRYVNDKQITDHYAIIPTGQGFGALSSLSPTAKRVYVSIVKRFLSIFYPPAVYQKIAITTKIDTESFFSSFRVLIEEGYLKVAGYQGNTNTAMQDTDGSAKTSTKTEADGKEKGSDEETEEEKDYDATFFEVIKSLKKGMKLPVRNFTIKEGETAPPKRYNSGSLILAMENAGQLIDDEELRAQIKGSGIGTSATRAEILNKLVKINYLSLNKKTQIMTPALMGELIYDVVNVSIRSLLNAELTASWEKGLTMVSDGTITKDEYIAKLEGFVGRMTEGVKGVNNANLLIPYFEQVAQNYKK
(376) DNA topoisomerase 1 [Clostridium phytofermentans ISDg]
1
MPKYLVIVESPAKAKTIKKFLGNNYEVLASNGHVRDLPKSQMGIDVENGFEPKYITIRGKGDLLAKLRKEVKKADKVYLATDPDREGEAISWHLSQTLKLDDKSASRITFNEITKNAIKNSIKEARDIDMNLVDSQQARRMLDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREEEINDFVPKEYWNLDASFKVKGEKKSLVAKFYGDTKKKISIESKEEMDKILADLKGAQFKITEVKRGERQKKSPLPFTTSTLQQEAAKLLNFSTQKTMRIAQQLYEGVDVKGHGTIGLISYLRTDSIRVSEEADTAAREFIKTQYKPEYVNSQDVNKTTGKKIQDAHEAIRPTYVDLTPVIVKESLSREQFRLYQLIWKRFIASRMQPAKYETSTAKIDGNGYRFTVASSKLIFDGFMAVYASEDEEEENTTSNMMSLSEETQLTFEEFNSSQHFTQAPPHYTEAALVKTLEELGIGRPSTYAPTITTIIARRYVIKENKNLYVTELGEAVNRIMKQAFPTIVDVNFTVNLEALLDGVEDGVVNWKTVVSNFYPDLESAVQDAEKQLEQITIEDEKTDVICSECGRNMVIKYGPHGKFLACPGFPDCRNTKPYFEKIGVACPLCGSDIIIKKTKKGRRFYGCENNPECEFMSWQKPSGKLCPICNGIMVEKGQKLVCVNEGCGHVENKEQN
(1399) DNA topoisomerase 1 [Desulfotomaculum acetoxidans DSM 771]
1
MSTTLVIVESPAKAKSIGKFLGKKYTVKASMGHVRDLPKSQFGVDVEAGFMPKYITIRGKGDTIKELRSAVKKADTVLLASDPDREGEAIAWHLQKLLKIEDNQPCRIEFNEITKQAIQNAVTHPRKIDYNRVNAQQARRILDRLVGYNLSPLLWRKVRKGLSAGRVQSVAVRLICEREEEIDSFEQVEYWTLTGKFLKAKAGFEGKLLKYRGEKLEVSDEESMQKILQALEGSSYVIEKVSRRERSRRPAAPFTTSSMQQEAYRKLNFTARKTMVVAQQLYEGLDLGKEGSTGLVTYIRTDSTRVSGTAKEEAKEYIDKQFGQAYTGEQDGEIKGQKERKIQDAHEAIRPTSVFREPDQVKKFLTPEQYKLYRLIWSRFVASQMSPAIIDTTSVDIAAGEYTFRSAGSIVKFSGFMKVYTEGNDDGQKEEIKTLPELAEGEKLELTELLPKQHFTQPPPRYTDASLIKLLEENGIGRPSTYAPIVETIQKRGYVSRENKQFFPTELGFVVVEMLKEHFPEIIDVEFTADMEKKLDHIEEGDTDWIKILEEFYGPFHETMEKAEEAIGKIELQDEVTEEICELCGRNMVIKFGRFGKFLACPGFPDCRNTKPLLEPTGVTCPLCSGEVVLRRTKKGRKFYGCSRYPECDFVTWDLPTNEKCPSCNSMMVKKSSKNKQMLSCVNQECKLKIEMSEDKK
(48) DNA topoisomerase [Desulfotomaculum acetoxidans DSM 771]
7
MKQLVLAEKPSVARDLSNVLGNFNKGNGYLESDAYIITWAIGHLVTLAEPDDYDAALKKWFLNTLPILPREFKLKPVSATLKQFNIVKSLLHRNDVGDIICATDSGREGELIFRYIYKLTDCQKPFKRLWLSETTPAAVRKGFDNLRPGNDLDRLAFAAEARSQADWLIGINATRAFTVKHNQLLSVGRVQTPTLALIVNREQEIRAFVPEKYWELFALFTKENGQTYIGKWFKKEKKAVENWEIPIQVGQKQTNQNPAASFEAAQGGIPSVMGEAVPSSNGQDKPVAMQTKFAAREAARDIQKKVTGQPGQVVSVEKKDIIEHPPLLFNLNDLQKEANKKFGLSAAKTLSVAQELYESRKLITYPRTDSRCITVEMGKTIPQRLGALAVVAEYENFIHLIKERKAFLNKRYINDSKVTDHTALIPTNVKPDLDKLSSDERRVYDLVVRRFLAAFFPPARYEQTQVITEVKQETFLSRGRVELDKGWKTVYDPVQDKLVDDEQGILPVIENEESVLTTKTDIKEKKTNPPKRYTEAALLSVMEGAGRLLNDEELKEAMRGSGLGTPATRAAIIERLLKVGYIERRKKTLLPTEKGENLIKLVPEQVKSPEMTARWEKALADIEDGQLNPGEFMSGIIEQTRQVVELARRQKTEGEPLRNNRDIIGKCPLCGRPVVEYPKSYSCSDYRAGCQFVIWKVILGKNITVEMARILLEKGRLEKQPGFISKNGKKFDAPLIIRNGRVEFDF
(1746) DNA topoisomerase 3 [Desulfotomaculum acetoxidans DSM 771]
2
MKSLVLAEKPSVAREIARILNCTIKGKGYLEGNKYIVTWALGHLVTLAEPEDYDEKYKTWRTEDLPMLPAEMKTVVIKKTGPQFHIVSKLMKRPDVRELIIATDAGREGELVARWIMKQARCQKPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAICRAEADWLIGLNVTRALTVKYNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANLGKFQAEWRDKSGKHNRFSDCLQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLTELQRDANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGYFAELVKPLTAKPLPINKRLVDNSKVTDHHAIIPTTERANLAALTAEEKNIYDLIVRRFIAVFYPAYSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNLPPLKKGDKVKVLSCKSVKGQTKPPARYTEASLLSAMEHPGKFIEDEILKESVKESGLGTPATRAEIIEKIISSNYVERRGKELIPTAKGIQLVELVPPELKQADLTAKWEQQLHDIAMGKSKRTKFISGIREHAEKIVTTVLNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRGSNLVCPDRSCGHRQVEKETSNRPCPQCKKRRMEIREGKGGKIIVCTHCRYQEKYVLQPKREAKVNIKAYSDSAPLVTNLSILANFKFNGAKEKSD
(903) DNA topoisomerase 1 [Eubacterium eligens ATCC 27750]
1
MHKYLVIVESPAKVKTISKFLGANYKVMASQGHVRDLPKSQMGVDIEHDYEPKYITIRGKGDILAALRKEAKKADKVYLATDPDREGEAISWHLAAALKLEDKDIYRITFNEITKNAVKASLKEARKIDMNLVDAQQARRVLDRVVGYGISPLLWAKIKRGLSAGRVQSVALRMICDRENEIDEFIPEEYWSMEAVLNIKGEKKPLIAKFYGDENGKIEIKNGAQMQDILDEVKKSDFSIESIKRGEKVKKSPLPFTTSTLQQEAAKTLNMSTKRTMNIAQQLYEGVDIKGRGTVGLITYLRTDSTRVADEAKVSSREYISQNYGEKYIPQEANAKKDDKKIQDAHEAIRPTDLNLSPAIVKESLQRDQFRLYQLIWKRFVASQMAPAVYETTSVKIMAGKYRFSVAASKVMFDGFMSVYKNDDDNEENNTLAKGLDENSELSLEDVNGVQHFTQPPAHFTEASLVKALEEQGIGRPSTYAPTISTIIARHYVIKENKNLYISELGNAVNNIMITAFPTIVDVKFTANMESLLDGVAEGTVEWKEIIRNFYPDLKVAIDEAEKELEHVKIEDEVTDVICDKCGRNMVIKYGPHGKFLGCPGFPECHNTKPYLEKIGVPCPKCGKDVIIKKTKKGRTFYGCDGYPDCDFVSWQRPSEKKCPKCGGYMVEKGNKIVCADETCGYVENKNDKEQ
(391) DNA topoisomerase [Eubacterium eligens ATCC 27750]
7
MLQENNNCVIDTEMRDIMGKSVYIAEKPSVAQEFAKALHVNFTRKDGYLEGGDHIVTWCVGHLVTMSYPDAYDPNLKRWSFDTLPFIPKEFKYEVIPAVAKQFNIVKDILTRNDVEYIYVCTDSGREGEYIYRLVRQEAGVKGKKERRVWIDSQTEEEILKGINTAKDISEYDNLSDSAYLRAKEDYLMGINFSRVLTLKYGRNIANYLHLDRAVVSVGRVMTCVLGMVVRREREIRSFVKTPFYRVIGQAQVENSTFDAEWRVSDKSMYAGTPYLYKDNGFKDREKAEELVKFLSDPLPAQGVVDSIERKKETKNPPLLYNLAEIQNECSKLFKISPDETLNIIQELYEKKLVTYPRTDARVLSTAVSKEIHKNIGGLRNFPPVKEIAEHILQNNMQKGIEKTRYCNDKAITDHYAIIPTGQGFNNLKNLSVTAARTYEIIVRRFLSIFYPPAIYQKVSIISDVKNEKLYASFKVLVDEGYLSVAKNSFAKARNDAKVKDDDSVDNKEDNKCDVALFEVLKKYRKGSTITFNGFNIKEGETSPPKRYNSGSIILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLNTIKYISINSKTQIITPTFLGEIIYDVVDNSIRHLLNPELTASWEKGLTGVAEGNITADEYMEKLDGFVSRRTRAVMALRNQVGLVGLFNETAKNYK
(1254) DNA topoisomerase 1 [Anaerococcus prevotii DSM 20548]
1
MAKNLVIVESPTKARSISKMLGRNYKVMATVGHLRDLPKSKFGVDIENNFEPEYIKVRGRAKTINELKKEAKKAENVYLATDPDREGEAISWHLQFLLDLDPEAKNRVEFHEITKENVKNAIKNPRKIDQNLVDAQQARRVMDRIVGYEISPILWKRVKAGLSAGRVQSVALKLIVDKQKEIDDFVPEEYWTITAHHKEGREKFDSEFYGQINKKIKISNENGADKVLNKIDKDKFEVVKITKTKKRRKPQKPYTTSTLQQDASNRLGFSTRFTMQLAQQLFEGIDVGDGSVGLITYMRTDANRISKEIVGEALSYIKEKYGPEYAGKGNTYGGKKKGSQDAHEAIRPTSIRRNPLEIKEYLTDQQYKLYKMIWERVVASQMTDYEFLSTQVLFDNNSLIFKTNGKITLFEGFNKLGANKENENILPELKEGDVISAESIDKDQHFTKPPARYTEASLVKTLEEFGIGRPSTYSATINQIISRNYVELEGRSIFPTDLGKTVNTFLQENFDDVINVEFTREMEDALDNIAEGDRFWKETLKSFYKDFEKDMKGVKKDGKDYKVRDEILEEKCPKCGKPLAIKHGRNGKFIGCTGFPDCNFTKSIVKSTGVKCPECEDGTIIEKVSKRGKRFYGCDNYPKCDFALWDPPTGEKCPECGSLLIHKKNRSTDEIKCSSCDYVKEKRR
(853) DNA topoisomerase 1 [Halanaerobium praevalens DSM 2228]
1
MAKKKKKLVIVESPAKAKTIKKFLGKDYKVEASMGHVRDLPKSKLGIDLESDFEPNYITIRGKGKTLNKLRKAAKKSKEVYLATDPDREGEAISWHLAYALKLSDQENNRIEFNEITKNAIQNAIKNPRNINKDLVDAQQARRLLDRIVGYRLSPLLWKKVRKGLSAGRVQSVAVKIICKREEEIRDFDEEEYWSLEVELKNDENQTLKADLYRIDNKKYNLATQEEVEQVVEAIKKEEFEIIKVKKRKRKRNPKSPFTTSTLQQRASTKLNFTAKKTMYIAQQLYEGIDIGSSGTVGLISYIRTDSTRLSNEAKKGAKDYILAEFGTDFLKKKKEKSKKNANAQDAHEAIRPTDTQRTPEKIKKHLSKDQFKLYDLIWKRFIASQMSSALYQNISAQFKVGEKYKFRVSGSRLLFPGHLILTGKEKEKDIDLPVLTEGEKYKLIKTNPEQHFTTPPPRFSEASLVKTLEEEGIGRPSTYAPTLSTIESRDYVKKEGRYFEPTELGETVTKLLTEYFPDVTDVEFTAELEKNLDEIENGNKDWKQILRDFYEPFYQRLENARENMESVNIVEETDEVCDKCGSPMVVKYGRYGKFLACSSYPECKNTKPYLVRTGVDCPDCEEGEIIERTSKKGRTFYGCSNYPDCNFMVWNKPVEKPCPKCKSLMVEKTTKAKGKHHKCTNKECGHIEKVD
(1638) DNA topoisomerase 1 [Thermoanaerobacter mathranii subsp. mathranii str. A3]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFTPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNFTKFEAKFYGTKEDKVELKTKEDVDKVLAALSEEYTVDKIKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYANPGANYASKKANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDIQEEEEKTVPVLQEGTKLLLKELKPTQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDNKNLKPTELGFIVTDALKEFFTKIVDVKFTAEMEEQLDKIEEGQAKWYEVVQEFYNDFYKTLKIAEEQMEEIDIKEEVEVTDIKCEICGRPMVIKKGRYGKFLACSGFPECKNTKPLYEKIGVKCPKCGGEIVRKKSKKGRMYYACENAPNCDFILWDKPVEEKCPVCGSLLIEKNTKNIHILKCSNAECDYQKEVK
(651) DNA topoisomerase [Faecalibacterium prausnitzii SL3/3]
7
MVGINASRLFSCLYNQPLAVGRVMTPVLAMTVVREAAIAAFTPEKFYTVDLELTSGCTASSRRIPEKSVAENLLKACRKEMVATIQRITRKEKSENPPPLYDLTTLQRDANRLLGYSAQQTLDYVQSLYEKKLTTYPRTDSCYITDDDEEMLEELTEELEGFLDITSADVDEAVPRTRRTVNREKVTDHHAILPTRSMLQADLDALPKGEQNVLKLIIARTLMAVSKPFRYLETLLTTECAGEEFTAKGKEILEEGWKAVERKVLADILNRKQELTALPNAAENEYGILNAELKEGQTSPPKHFTEDTLLHAMETASADSMPEGVERQGIGTPATRAATIEKLVQKGFLERKGTKKTKVLLPTDKGKALITVMPEEIQSADMTADWEAKLLQIERSEMEPETFMTEIKEMISSLVTTTEAAKGANALMKNKIIGVCPNCGANVVEREKGWFCESNPCRFVLWKDNAFFKRLGKRLDGRMADKLLRDGHVRLKDCKSAKGKTYNATVLLSTEPDGRSKFSLEFEGGC
(1511) DNA topoisomerase [Faecalibacterium prausnitzii SL3/3]
7
MEDAAIREGFANLRPDSDYDALYQSALCRAKADWLVGINATRLFSVLYHKTLTVGRVQTPTLKMLVDRDAKILRFQKEKYYTVGIQSGSLKAGSGRIADAETANSLKEKCTGTTTVCTSVKREKKTEQPPKLYDLTTLQREVNRLFGFTAKQTLDYAQQLYEKKLLTYPRTDSQYLTEDMGQTVRHLVSDLLGLLPFAQRLVLTPDVSRVLNSNKVSDHHAIIPTAEFAKQGFTGLAESECKLMNLVCSKLLCAVAIPHEYETVTAVFSCAGNEFTAKGKTVLVPGWKEIDQRFRSTLKADTEEEVLNTLPELAEGQSFSVTANVSEHFTSPPKAYTEDTLLSAMEWAGAEDMPEDKVNCSAGAREGGLGQAERKGLGTPATRAAILEKLVQIGFVQRKGKQLVPTKDGINLAVVLPESLTSPALTAEWENRLTEIAKGNADPDEFMAEIEAQVHQLVKTYSCISADKQNLFQSERVIIGKCPRCGENVYDGKKNFYCGNRGCQFVMWKNDRFFEQRKKAFTPKIAAALLKNGKAKVKGLYSEKTGKTYDATVLLADTGGKYVNYRVERKE
(1654) DNA topoisomerase III, bacteria and conjugative plasmid [Faecalibacterium prausnitzii SL3/3]
7
MRYKLVIAEKPSVAQSLAAVIGATARKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGEMIFRSVYELADCQKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPVPFYTVALELPGLTVSGERMSDRASAEQMKEACQDAAVAIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVANAMPFCKEIAITCDPHTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACADGEFTAKGKTVKHPGWKALEDACRAKMKDAEPKKEGAEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLSAMETAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIEHGQLAPEEFLAGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQSKECRFAIWKNNKWWTAKKKQPTKAVVSALLKDGCVRVTGLYSEKTGKTYDATVVLEDDGQYANFKLEFDQRKGGSR
(1214) DNA topoisomerase 1 [Faecalibacterium prausnitzii SL3/3]
1
MAKLVIVESPAKAKTIGKYLGDDYEVTASMGHIRDLPASQLGIDVEHGYTPQYISIKGKEKLIKELKSKAKHADGVLLATDPDREGEAISWHLANILGLDPHEPNRVTFDEITKKGVKEGMAHPRAIDEDLFNAQQARRVLDRLVGYKLSPFLWRKVRRGLSAGRVQSVAVRLIDDREKEIENFKPDEYWNVDATLGAGHKSFVARLATDANGKKLLPKSEAEARAIEKGLEGASYVVSELKRGKRAKQPTPAFITSTLQQEASRRLGFTATRTMRAAQTLYEGVDIAGHGMMGLITYMRTDSLRISDEAVAAAKEYIAGAYGEAYICPYKRTWKTKSATAAQDAHEAIRPSVPSLTPDEVDKSISGDTAKLYRMIWSRFMASQMADCQQDTVSVTVSAADYHFKASGYTVTFDGFTALYEEATDEKEKKETNLPPLEQGQVLKLRELKSEQKFTQPPARYTEATLIKALEENGIGRPSTYAPIITTIIDRGYVERDQKKLKPTLLGRAVDGLMLEQFPHIVDVDFSAQMEKNLDKVESGKADWRKTVDDFYQGFEASLEQAEKNMEGKKVKVPDEPSSEVCDLCGRPMVIKVGKYGKFLACSGFPECRGTKRLVKDTGGICPKCGKGRLLERKSSKGRIYYGCECYPDCDFMTWDMPVATKCEKCGSTLFRKGGKLYCAKEGCGFEMPVPKKD
(329) Topoisomerase IA [Ruminococcus bromii L2-63]
2
MAFRLVIAEKPSVAQTIAAALGIKGKQDGYIEGGGYLISWCVGHLVQLAEAAAYGEQYKKMEF
(1286) DNA topoisomerase 1 [Ruminococcus bromii L2-63]
1
MSDLVIVESPAKAKTIKKYLGSGYEVVASMGHVRDLPKSRLSVDIKKNFAPKYEIIKGKEKLVDDLKSAAEKSEHIYLATDPDREGEAISWHLAYILGLPTDETNRVEFNEITKSGVTNGMSNPRSINIDLVNAQQARRILDRLVGYKLSPFISQKIRRGLSAGRVQSVAVRIIVDREEEIRKFKPEEYWSIDAKFIPKGSRKSFSASLYSDENGKIKITNGEQADKIEADLQNAEYVITKVKNGTRKKSPAPPFITSTLQQEASRKLGFQSRRTMKVAQELYEGVDIEGMGATGLITYMRTDSLRISNVAIEEVTEYIKNSYGEKFLPPKPRFFKSRSNAQDGHEAIRPSMPSLTPDSVKASLTSDQYKLYKLIWNRFTASQMADCIQKTTQADIVANGYTFKASGYRVDFEGFTTLYVESKDVEEEKTTQLPPLEKDMIVRCKELKKNQHFTQPPARYTEASLIKALEEYGIGRPSTYAATITTITSHEYVKREGKSLVPTELGEVTTNLMKERFPKIVNVKFTNQMEEDLDKVEKGTEEWHALLDNFYGDFDKTLKKAKADMEGVKLHLKEDETDIICDKCGRQMVVKVGRYGKFIACPGYPECKNIIKYVEKTGVKCPKCGGDVIIKRTKTKRIFYGCSNYPECDFVSWNEPTNEKCPQCGGILFKKKGKKPTLFCATEGCGYTKTADTDDK
(34) DNA topoisomerase [Ruminococcus bromii L2-63]
7
MKLVIAEKPSVGAAIAAVMGANEKRSGYFEGGGYLVSWCIGHLISLADAATYNEQFRKWKYDDLPIVPQEWQFIVASGKEQQFSILKDLMHRSDVTEIINACDSGREGELIFRFVYEQANCKKPFSRLWISSMEASAIREGFSNLKDGRGYDNLYQSALCRAKADWLIGINATRLFSILYHKTLNVGRVQTPTLAMLVNRDYAISSFKKEKYHVVRLDVGGVAALSERQDDEAAARQMKAACEKSQAVCTSLKKEKKTAAPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYPRTDSKYITSDMEGSTKELITGLCAALPFMQGVKLQADLARICDNSKVTDHHAILPTAEFVKTGFSSLAESEKKLMTLVCAKLLCAVAAPYEYEAVTAVFTCGGYTFTAKGRTTLCEGWREIERLSRAASGEQDEDAEPEAVLPPLAEGQTFDNPAAEISERYTQPPKAFTEDTLLSAMESAGKEDTPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLVAILPDSLTSPQLTAEWETRLTGIAKGSDSPADFMRGIEEMTAGLVKTYSAISEDKAKLFTPQREAIGTCPRCGAAVYEGKKNFYCSDRACSFVMWKNDRFFEQRKKAFTKAIAAALLKDGKVKIKGMYSTKTGKTFDGVVLLADTGGKYVNFRVEQNRK
(92) DNA topoisomerase III, bacteria and conjugative plasmid [Ruminococcus torques L2-14]
7
MAQHKLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGELIFRSVYELAGCKKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFQPVPFYTVALELPGLTVSGERMADKAAAKQLKETCRGANVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTSDMADSLPVLVNLVANAMPFRKGIAITCDPQTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACAGGEFTAKGKTVKHPGWKALEDAYRAKMKDAEPKKEGAEKALPELTEGQTLSVAAAIVKEGKSSPPQHFTEDTLLSAMETAGKENMPEEAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIERGQLAPEEFLDGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQNDSCKFAIWKNNKWWDAKKKQPTKAVVSALLNDGCVRVTGLYSEKTGKTYDAAVVLEDDGQYANFKLEFDQRKGGSR
(644) DNA topoisomerase 1 [Ruminococcus torques L2-14]
1
MAHYLVIVESPAKVKTIKKFLGSNYTVAASQGHVRDLPKSQLGIDVENDYEPKYITIRGKGEILATLRKEAKKSDKVYLATDPDREGEAISWHLAAALKLDEKKMRRITFNEITKNAVKASLKAPRDIDMDLVDAQQARRELDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIVADREAEIDAFIPEEYWSLDAQLKVKGEKRPLTAKFYGTEKKKMTIHSKEEMDEILKKLENEEFQITDIKNSERTRKAPLPFTTSTLQQEAAKALNFGTQKTMRIAQQLYEGVDIKGNGTVGVITYLRTDSTRISEEADAAARSYIAETYGEAYVAEGTKTKSADKKIQDAHEAIRPTDITRTPAAIKDSLSRDQFRLYQLIWKRFTASRMQPAKYETTAVKIGAGEYCFTVSTARVAFDGFRSVYVEAEEEKEESNVLVGHLSMDSVLTKEEFDPKQHFTQPPAHYTEASLVKTMEELGIGRPSTYAPTISLILGRRYITKEGKNLYLTEIGEVVNNIMKQSFPSIVDVHFTANMEGLLDMVEEGKVPWKEVIRNFYPDLEEAVEIAEKELEEVKIEDEVTDVICEECGRNMVIKYGPHGKFLACPGFPECRNTKPYLEKIGVPCPVCGKEVVIRKTKKGRKYYGCEDNPECEFMSWQKPSSKKCPECGGYMVEKGNKLVCADEKCGYVETIKKED
(489) DNA topoisomerase [Ruminococcus torques L2-14]
7
MGKSVYIAEKPSVAQEFAKALKLNTKRRDGYLESDEAIVTWCVGHLVTMSYPEEYDPALKRWNLQTLPFIPEEFKYEVIPSVAKQFQIVSGILNREDVDTIYVCTDSGREGEYIYRLVEQEAHVEGKKRRRVWIDSQTEEEILRGIREAKDLSEYDNLGASAYLRAKEDYLMGINFSRLLTLKYGNSISNFLQTKYSVISVGRVMTCVLGMVVRREREIRDFVKTPFYRVLSTIDAQGHTFEGEWRAVKGSRYFESYDLYKENGFKERKKAEELIQYLQTPDDESVNVAGIQRQLGLNCRIESIEKKKEKKNPPLLYNLAELQNDCSKRFKISPDETLRIVQELYEKKLVTYPRTDARVLSTAVAKEITRNLNGLSKYPMAAPYMQDILNFGSYKTLAKTRYVNDKQITDHYAIIPTGQGLNALSTVSSTAKGVYDLIVRRFLSIFYPPAVYQKVAIVTKIKEESFFSSFKVLAEEGYLKVAGIPKKKASQTATKDSSNGNSENTNNDTNDEAGSDSSDQSLDTGLFEVIKSLKKGAVLQVRALDIKEGETSPPKRYNSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLVNIKYLALNKKTQVITPTLQGEMIYDVVDHSIRSLLNPELTASWEKGLNYVAEGSITSDEYMRKLDHFITSRTVGVKGLNNQYQLRACYEKAAGFYPSVNNNKTIGRTKTGNKSK
(473) DNA topoisomerase III, bacteria and conjugative plasmid [Eubacterium siraeum 70/3]
7
MMRYKLVIAEKPSVAQSLAAVIGATARKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGEMIFRSVYELADCQKPMKRLWISSMEDSAIREGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPVPFYTVALELPGLTVSGERMSDRASAEQMKEACQDAAVAIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVANAMPFCKEIAITCDPHTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLLCAVAQPHIYSETVVIAACADGEFTAKGKTVKHPGWKALEDACRAKMKDAEPKKEGAEKALPELTEGQTLSVSAAIVKEGKSSPPQHFTEDTLLSAMETAGKEDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKSRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIEHGQLAPEEFLAGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQSKECRFAIWKNNKWWTAKKKQPTKAVVSALLKDGCVRVTGLYSEKTGKTYDATVVLEDDGQYANFKLEFDQRKGGSR
(1507) DNA topoisomerase [Eubacterium siraeum 70/3]
3
MIVIYAEKYSLGRTIAEALGAYKKTVNPKEPSIAHWSLNLNGEEAILCHGAGHLCGLAPAEDYNESYKFWSFDNYPIIPEHFITRVKDNNYSRLAYDYVKQFFDKADLIINATDADREGELIFAYLYEVLHCTVPYKRVWITDLTPFKIRKAFAELRPAKDMKPLENAGRIRSATDWLVGINTSVAATLKFGGTDNVFACGRVKMPTLAMIVKREREIRNYVKKPFYKIVANIEATDGAKFTAEAADKYDTETAAKAVIDEIKLNTAKAIKVEVLQKQTAAPLLYNTTHLLADLSKCTDLTIDMLTKLVQSLYENRLITYPRTSSEHLTDAMKDETVKIIKLLFEMPEFAKYAIPVDNFAPCTRRHYDDSKVDSHTAITPTALVPNDLSGMSENERKAYTLLALSIIRTVYPKAVTENVKAVFQIDNQLFTATGTNIISPGWFAVDATPKVIGLPEIVKDNDYKVIGFDVKEGQNEPPKYYTDATLLTAMELAGDNIEDEQTRNLIKLEKRGLGTAATRQGIIKELYEKGYIARRTKKNGNMIKGIMPTEKGMYIIDALEKTVPDMLSVDMTSDMEMELDKIARGKSDGNDFLNNYKKLVAKWVELIKNSDTSAMAGNTLICPLCSKPLIKKKVGWCCTGYSKDNPDSCRFYIANEICGKKISDVIAKELTLKRSTSIIKGFTSQSGKTFDAKLTIKADNTIGFEFPERLKCPVCGKEMIKSSKGWVCTGYKNGCNFFIAGTICGKCITDTIATMLCANKRTRIINGFTSKSGKAFSAALIVKDGKIDFDFPAQSQKRSK
(1780) DNA topoisomerase 1 [Mahella australiensis 50-1 BON]
1
MANNLVIVESPAKAKTISKFLGRGYKVEASMGHVRDLPKSQMGIDIEHGFEPKYITIRGKGEIVDKLKKQAKAVDRVLLATDPDREGEAISWHLAQLLDIDMDKACRIEFHEITKNAIKDALKHVRPIDKNLVDAQQARRVLDRLVGYSISPLLWRKIRKGLSAGRVQSVALRLICDRQQEIDNFVPQEYWTLTALLASDKGETLEARFYGKDTKKQELKDKESVDAIIKDINGSDFIVEKIERGQRKRKASAPFVTSTLQQEAARKLRFTAKKTMAVAQQLYEGVELGKEGMVGLITYMRTDSVRVSQEARREARNYIAERFGDNYVPDKPNEFRNRKGTQDAHEAIRPTYINYTPDYVKSFLSRDQYRLYELIYNRFIASQMSDAVYDTISVTIKAGDYVFKASGSTLIFPGHLALYMEGQDDDNDDKEQKLPPLEEGQRLILKKWMPEQHFTQPPPLYTEASLVKMLEEKGIGRPSTYAPIISTIVERGYVVREKRTLKPTELGILVNDMLKEHFPDIVDVSFTAQMEQMLDDVEEGQKDWHNIISEFYFPFKSVLDKADQSIEKVDVPDEQSDVICEKCGRRMVIKQGRYGKFLACPGFPECRNTKPLLEELKVTCPKCGGHIQIKRSKRGRKFYGCENYPKCDFVSWDEPTGELCPECGYPVVIKYSKNGRKYTRCSNKDCKYTGQKLAGEAK
(180) DNA topoisomerase 1 [Clostridium sp. BNL1100]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAVKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATKMICDREDEIENFESQEYWSITAKLTKPKASPNFEARFYGIGKEKIELTNEEQVNSILDEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGFTTKRTMMVAQQLYEGIEIKGHGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPENPRVYKNKSASQDAHEAIRPTYMDMAPEGLKEFLSAEQYKLYKLIWDRFISSQMSSAIYDTVAADITAGKYMFKANGSKVKFPGFMVLYIEGNDVEGKDEDGEQNEKENNLPQLNEGDILELKKNTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAQMESELDDVEDGNKEWKAVMRDFYSSFAGVLKEAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNTKPIVEEAGVECPLCKGKVLIKKTKKGKKYIGCERNPECSFMSWDMPSPNKEMCPVCGAFMLQKSSGKKKALKCSNDKCTSNTETSTDTK
(250) DNA topoisomerase 3 [Clostridium sp. BNL1100]
2
MGFTLVIAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFSVQWQDGRTNQTRTFNKEEADGIVAKITGQIGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKISVTKRFVDNSKVTDHHAIIPTEQFVDLSSLNSEERNIYDLIVKRFIAVLSQPFEYEQTTVKLNVAGESFYAKGKIVRSSGWKTVYDGFGKLDEDSDEDDNDQSLPDIQKGHKAKVVAPKAINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERRGKEIYPTSKGTQLISLVPADLKSPELTAKWEQQLSLISKGKANSNAFVGEMKNYAKKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHVCPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGEQVDKKDVARFMRQQDKDESINSALADALAKWKK
(922) DNA topoisomerase 3 [Tepidanaerobacter acetatoxydans Re1]
2
MSKTLVLAEKPSVARDIARVMNCGKNGNGYLEGQKYIITWALGHLVTLAEPEAYGNRYKSWRMEDLPILPKDLKLEIIKQSRRQFNIVKEQMNRNDVNSIVIATDAGREGELVARWIIKMANVKKPIKRLWISSVTDKAIRDGFNNLKDGKQYENLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAMIAKREEEIQNFKPRDFYGITATVGNLKLVWQDSQTRDIRTFDKGKIDRILASLRGKNAEVIDVTKTLKKSFAPQLYDLTQLQRDANKIFGFSAKETLSIMQRLYENHKLLTYPRTDSRFITTDIVATLEDRVKACGVGPYRTAAFKIKRPIKGNKSFVDNGKVTDHHAIIPTEQPAFLDSLSENERKIYDLVVKRFLAAMYPPFEYEQTTIKAKIGTEIFIAKGKTVIALGWKEVYEGFDDESSEDENLNDGIFEQILPTMSKGDILKITSIFQTQGRTRPPAPLNEGTLLAAMENPVKYMPKDNKDLIKVIGETGGIGTVATRADIIEKLFNSFLIEKRGKDIFITSKGRQLLDLVPEELKSPALTAQWEQKLSAIAQGALKKDTFVNDMKNYAKRAVQDIKNSEDKFRHDNLTRSKCPQCGKYMLEVNGKKGKMLICQDRECGYREKLSKVTNARCPNCHKRLELHGEGEGQIFICNCGYREKLSAFNERKASEGNNKVSKRDVAKYLQKQKKDEDKPINTELADALAKLKL
(1026) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(921) DNA topoisomerase 3 [Tepidanaerobacter acetatoxydans Re1]
2
MSKTLVLAEKPSVARDIARVMNCGKNGNGYLEGQKYIITWALGHLVTLAEPEAYGNRYKSWRMEDLPILPKDLKLEIIKQSRRQFNIVKEQMNRNDVNSIVIATDAGREGELVARWIIKMANVKKPIKRLWISSVTDKAIRDGFNNLKDGKQYENLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAMIAKREEEIQNFKPRDFYGITATVGNLKLVWQDSQTRDIRTFDKGKIDRILASLRGKNAEVIDVTKTLKKSFAPQLYDLTQLQRDANKIFGFSAKETLSIMQRLYENHKLLTYPRTDSRFITTDIVATLEDRVKACGVGPYRTAAFKIKRPIKGNKSFVDNGKVTDHHAIIPTEQPAFLDSLSENERKIYDLVVKRFLAAMYPPFEYEQTTIKAKIGTEIFIAKGKTVIALGWKEVYEGFDDESSEDENLNDGIFEQILPTMSKGDILKITSIFQTQGRTRPPAPLNEGTLLAAMENPVKYMPKDNKDLIKVIGETGGIGTVATRADIIEKLFNSFLIEKRGKDIFITSKGRQLLDLVPEELKSPALTAQWEQKLSAIAQGALKKDTFVNDMKNYAKRAVQDIKNSEDKFRHDNLTRSKCPQCGKYMLEVNGKKGKMLICQDRECGYREKLSKVTNARCPNCHKRLELHGEGEGQIFICNCGYREKLSAFNERKASEGNNKVSKRDVAKYLQKQKKDEDKPINTELADALAKLKL
(1025) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(1328) DNA topoisomerase 1 [Clostridium ljungdahlii DSM 13528]
1
MGQKLVIVESPAKAKTIGKYLGKNYVVKASMGHVRDLPKSQLGVDIDNEYTPKYITIRGKGELLDKLRKEAKKSEKVYLATDPDREGEAISWHLSHALKLDENEKCRIEFHEITKNAVKSSIKSARLININLVNAQQARRVLDRLVGYKISPILWRKIKWGLSAGRVQSVALKMICEREKKIVDFVPQEYWTIECELHKENESKCFNVKLTTFNKKKIEIGSKDEVDKIIEELKQGQFIVKSIKNTNKNRTPLPPFTTSTLQQDAYKKLNFSTKRTMSIAQQIYEGVDIKGYGTIGLITYMRTDSVRIAQEAQEACRDFVANKFGKEYIEEKPRNFKSKKNIQDAHEAIRPTNVEITPEIAKENLKPEQYKLYNLIWNRFVASQMSSCQIDVKSIDIVNSNYGLKVSGSRIKFDGFMKVYKYATEEEKSDISLPKLEEGEKLLRKSIDGKQHFTQPPARFSEASLVKTLEENGIGRPSTYAPILSTLLDRKYIQREKKTLIPTELGDIVNNIVSQYFKQVVDVEFTAAMESKLDSVEDGKDDWRKVVGEFYEPLKKSIEIAEKEVARITIEDKVTDIKCDKCGRNMVIKHGRFGDFLACPGYPECKNTKPIVEELDVKCPKCQGKVLIKRSRKGRKFYGCSNYPDCDFVSWFEPTNEKCKECGNYMVKKYNKSKGNYLECSNSECKHREYKAVEDGDEKTAK
(151) DNA topoisomerase [Clostridium ljungdahlii DSM 13528]
3
MKSLIIAEKPSLAMSIVKSIGSMERNNGYFENKNYIVTFAYGHLLQLYDVDDYFGREKTKWTLKELPFVPKEFKFRLRKDEGVKKQYEIIKSLIKRNDVQEIVNCGDADREGEVIVNNIIFRAFEEEHVTKPVKRLWLPEQTRQTIIQSLKDLRDDIEYKNLYDEGLARTYLDWSYGINLTRYLSIKSGSFLPVGRVLIPIVKYVYDRDEKIENFKPETYFEIGAVINKDNLHIKTKLKDRKFAANERDKAEKLLNNLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKEEKMSLDDTLKNLQKLYEAGYTTYPRTNTEYLAENEKDRIKSVIAAVKENFNADISFKDNKKIFNSKKVESHSAITPTIKIPRKEKLSEGEKKVYTAIKNRFISNFLNEETIIEETSVVIKIDDEIIQLKGNVIKSPGFLKYEKSKRENELPQFVEGEELDTKLSVDQKETQKPGRVTESELNNFLKNPFKKQEVEDLEGENDDEEYKLILEGCEIGTVATRAGIIKNAKKYEYIKELKGHLECENKGKKLIEALEKLKIDLNKEKTVEFGKQLKKVYKEEIGINEIIDKVKDELNSIVQNGNKIKIEKLYLYNNKSDSKIKIESIGKCPVCHEGEVVENKSGYGCNRWKEGCKFFVGNKIAGKEILKTHVKKLIKDSKTNVIKGFKGKSGKKFNASLVIDKEGKIVFNFENEVLGKCPCCGHDIVEGKNAFGCSNWKEGCKFTIWKNDKYLACMGKKPTKTMVCELLKNGKVKIKGLKGKDGNIFDAYLMLIKNENENKDKYPYKWKMQITK
(22) DNA topoisomerase 3 [Clostridium ljungdahlii DSM 13528]
2
MGKILVLAEKPSVGREIARVLKCRKKGNGWLEGEKYIVTWALGHLVTLADPEAYDDKYKTWKLEDLPMLPKYLKLVVIKQTGKQFNAVKEQLNRKDVTEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAINEGFRNLKPSSQYDNLYRAAQCRAEADWIVGLNVTRALTCKHNAQLSAGRVQTPTLAMIVHREEEIKNFKPKDYYSIIGNANGYTLQWQNGNGHFNTFDENFANKVVSKVNGQNGKILDVIKSDKKKYAPALYDLTELQRDANRLFGYSAKQTLSIMQRLYENYKFLTYPRTDSRYISADIVPTLPERLKAISVGNYSKFAMEIMRGKIRAHKGFVDDSKVSDHHAIIPTEEKVILSKLSNEERKVYDLVVKRFLSVMLPPFEYVQTTVKAEINGENFAASGKVIKSKGWKAVYDKNEDFDDNDGLHENQLKEQVLPNLNRGDSIKLTAVKMHKGQTKPPARFNEGTLLSAMENPQKYINMNKEYAKTLGETGGLGTVATRADIIEKLFNTFYIEKKGKEIIPTSKGKQVVELVPEDLKSPLLTAKWETDLNLISKGKLNDKSFIGNMRNYSVKLVEDVKGSHDKFRHDNLSGAKCPECGKYMLEVNGKHGRMLVCQDRACGHRENLAKLTNARCPECHKKLELRGHGDGQVYVCINNNCNFREKASSFNKRFDNKQGKNSKRDVANYMKKMKKESEVPMNSALADALAKLKLK
(478) DNA topoisomerase 1 [Ammonifex degensii KC4]
1
MKHLIIVESPAKARTLSKFLGSQFLVKASMGHVRDLPKSELGVDLENGFTPKYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWHLCHLLGIPPETPCRVEFHEITKNAVLNSLKSPRPIDLNRVNAQQARRVLDRLVGYGLSPLLWRKVKRGLSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLARLARFKGKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQEANRRLGMRLERTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIKEHYGAEFVGDVPPKERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLIWERFLAAHMAPAKYFLTRAEIEVGDYTFYATGRQLLFPGFLRLWRPEEEEEEGKLPPLREGEVLTFQEFVPQQHFTTPPPRYTEGTLVKALEEKGVGRPSTYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLKEHFPGIVDVGFTAAMEEKLDLVEEGQADWVDILREFYQSFSQDLVRADAAIEKVSLPDTFTDISCPRCGCPMVKKTGRYGEFLACSGYPECQMRMPVGTGVKCPRCGGELVKRRSKKGRYFYGCNRYPECNFVVWSEPVPEPCPECGSLMVRRGRGKKKRVICTNESCGYQRLEE
(982) Reverse gyrase [Ammonifex degensii KC4]
6
MELFLLAHGCPNCSGSVTDERLAAGLPCPQCLPQAGNNLSLAAVCCALRKENKIRELSPFCRAEEGLKEFELFFRQVTGLNLSPLQRLWAKRFFLEEPFAIIAPPGVGKTTFGLTVSLYNPQKSLILVPTRLLVWQVAEKLSHFAEKAGSKKKILSMTGKAKEKKELMQSEYDILVATTQFFYRHWSEIASHPITLVFIDDVDALLKSSRQVDSLFYFLGYSPEEVERALRSPEGEPREAGKRPQRLLILSSATLKPRTNRVRLFQRLMGFSVQRAVSTQRRVVDCYEEVPDFARALARAAELVRQLGPGGLVLVSPEEGREGVKEATAYLQAQGIEAESYLELTPEELVSRLAEGSLEVAVGLAHPTNPLVRGLDLPHVLKYVIFVGAPSHFFPLDLSPAPGALHGLGLALFPLFTPEEQRQVLRELRYLRPYLNLPADAVSRYPALEKRVQAFASFLKEKLKDPSFWEKIRAAEDLNLREEEGKLYLVLGDATTYLQASGRVSRLTAAGLTRGLAITLCTERRVLLSLKKRLRALTPAEIEFIPLQEVDLAGVMRGIEEDRRRIKAGELADKEGPRTALVVVESPHKARTIASFWGKPGIRRVKGVLAYEIPADERHLIITASLGHVFNLSRQQGFFGVLTFNHHFLPVFDTIKIYRETGEELVDPEEVARYPEGTVWDKQEILRGLQHLAFEVDEVYIASDPDAEGEKIAYDLYLSLRPFNPHIYRLEFHEVTPSAFRRALENPGQVNLYRVQAQLTRRVLDRWVGFCLSRRLWQKFGNRHLSAGRVQTPVLGWVVARAEEGRQRKARLTFSLGEATFTLEVPDRELGQKIFGELEKLSWEILEISEEERSPLPPFTTDTILTEAAHRLRLSAPVTMKLLQELFELGFITYHRTDSTRVSETGRFLVAKPFILQHYGEELFHPRSWGEGGAHEAIRPTRPMTEAELRWMVGAGLVDLSQERALELYGLIFRRFMASQMAPARVRKAKVRFRVPSYAWETEVVVEQIAPGFALLWPNFSVTELRPEARLTGKEYRELPLAEPYTEGTLVQEMKRQGIGRPSTYAEIVATLLNRGYLVVRGGRLYPTRLGFKVYRYLKENFPEYADTALTREIEAAMDLIAEGKEDYQEVLQKLYKVREILA
(546) DNA topoisomerase 1 [Halanaerobium hydrogeniformans]
1
MAKKNKNLVIVESPAKAKTIAKFLGRNYKVKASMGHVIDLPKSKMGIDIENNFEPNYITIRGKGKTLAKLRKEAKKSNEVYLATDPDREGEAISWHLSHALKLSEEDNNRIEFNEITKNAIKNAIKKPRQIDKNLVDAQQARRLLDRLVGYRLSPLLWKKVRKGLSAGRVQTIAVKLICEREEEIRNFEEEEYWTIDVDLKKDKDKLTASLYRIDNKKYNIDSEEAANKIVSDIKKEDFEIIKVKKRKRRRNPKSAFTTSTLQQTASSKLNYSAKKTMYLAQQLYEGMDIGSSGSVGLISYIRTDSTRLSEEAKAGAAKYIEAEFGDKFLRSKKKKKKKNKNSQDAHEAIRPTDTMRTPDKMKKHLSKDQYKLYDLIWRRFVASQMSPALYESISAQFKAGEKYKFRVSGSRLLFPGHLILTGKAKEDKIDLPVLKEGDVYKLQDVKPEQHFTKPPARFSEASLVKTLEEEGIGRPSTYAPTLSTIVSRDYVEKDGRYLKPTELGETVTELLSEYFPDVTDVEFTASLEQRLDEIEKGNEDWKKLLKDFYQPFYERLEHARENMERVQIVEETDEVCEVCGKPMVVKYGRYGKFLACSGYPDCKNTKPYLIKTGVDCPECDDGEVIERTSKKGRTFFGCSNYPECNFMAWNKPVEKPCPECGGVMVEKTTKAKGEHYKCINKECGHTEKAE
(1037) DNA topoisomerase 1 [Clostridium tetani E88]
1
MIMGQKLIIVESPAKAKTIGKYLDKTYHVEASMGHIRDLPKSQLGVDIDNNYEPKYITIRGKGELLTKIKKHAKKCDEIYLATDPDREGEAISWHLSQALKLEDNKKCRIVFNEITKSAVKNAIKEPREIDIDLVNAQQARRVLDRLVGYKISPILWRKVRWGLSAGRVQSVVLKMICDREKEIEEFIPKEYWTIECKLNKDRKDFLVKLISKDNKKIEINTEEESNNIIKELKQGQFTVDKIKKTNKNKNPLPPFITSTLQQDAYRKLNFSTKKTMSVAQQLYEGIDIKGHGTVGLITYMRTDSVRISKEAQNKARQFLENVYGKEYIPEKPRDYKGKKNIQDAHEAIRPTNIEITPKIALENLNSDQYKLYSLIWNRFMASQMAACVMEVNSVDVKNSEYIFRATGSIVKFDGFMIIYEYLNEDEKENINIPKLEKGELLKEKSIDSKQHFTQPPGRFSEASLVKVLEDNGIGRPSTYAPIISTLLERTYIERENRTLKSTELGVIVNNIMVEYFKPVVDAEFTAEMENKLDSIEEGNENWKNTVDEFYSPLKELIETAEKEVEKVTLEEKVTDVKCEKCGNNMVVKHGRFGDFLACPGYPECKNTKPIVHQLDVKCPKCHGEIVLKKSKKGRKFYGCSNYPKCDFVSWFEPVERKCDVCGNYMVKRYTKAKGDYIECSNKECKHKIMPEKKQE
(405) DNA topoisomerase 3 [Clostridium tetani E88]
2
MGKTLVLAEKPSVGREIARVLKCNKNSRSYIESNKYVVTWALGHLVTLADPEVYDNKYKKWEMETLPMLPKYMKLCVIGKTSKQFNEVKKLMNRNDIDEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAIIDGFNNLKPGKDYENLYKSAVCRSEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLALIVEREEEIKNFKPRDYYNIVAKTKGIQFNWQDKKGQMATFNEDFANNILAKVSGEIGNVTEVIEKDKKQYAPALYDLTELQRDANRIFGYSAKETLSIMQRLYENHKVLTYPRTDSRYISKDIVATIPQRLKSISIGIYSKFAEEILRGKIVAHKGFVDDSKVSDHHAIIPTEERVKLSNLSGDERKIYDLVIKRFLSVMLPPFEYIQTTIKVEVNGEVFIAKGKNIKHNGWKAVYNKEDLNEDNNDGDGLKEQVLPQIIKGDAIKFNLVNINKGQTKPPARFNEGTLLSAMENPQKYIKLNKEYAKTLGETGGLGTVATRADIIEKLYNSFYIEKKGKEIIPTSKGKQIIDLVPQDLKSPILTAEWEKKLELISKGKISGKEFINNMRNYSTKLVQDVKNSNEKYIHNNLTGTKCPNCEKYMLEVNGKRGKILVCQDRECGYRENISRFTNVRCPECHKKLELRGEGEGQIYVCSKCTFREKLSSFNKRFKEKGNNADKREVSRYMKKMKEQDKEPMNSALADALAKLNLK
(1761) DNA topoisomerase [Clostridium tetani E88]
3
MNLAKVIIAEKPSVAKNIADALNIKTRKDGYFEGKEYLITWAFGHLLQLYDAKDYNEIMKGWRLEKFPFIPMNFKYKIKQQNNNKNITDEGAEKQINIIKSLIERENVEAIISATDLDREGQIIGDELFSYLQIKKPIYRLLLNEWTPDEVKNGMKNLKCNEDMKFLRDAGISRQWSDWIIGINLTSVATLKYNIEDNKILNIGRVILPTLKIIYDRDKEIENFKATTYYKLLANFKTKKDKEFEGTYYEKNSEKFQDKSYLKIIEDLLKNKTYNIVDKHVEKKKEYAPYLFNLSNLQGYVTSKYKGWTSDKVLKVAQSLYEKKFITYPRTSSSVLDESLEGRAKKVLETLKKGLSYENQIRFNKSKRIFDSSKVESHSAITPTYIKPSKLTRDEEIVYIAIKNRFIMQFMPIAEFEETKITIKANDEDVKGEFLSKGKVQIVEGWRIVEKIETKDTILPLVEVKEKVDAVNSKIKTVTKKPPKHHTEKTLLRVMETCGKSFKDDENSEEMMNAILSGFSIGTAATRADTIKKLKDIGYIEAKGKSLICAPLGRTMIEIFPVKELLDLEYTGKLEKTLSDIEKGKFGKKEFMDLIYEFTNRAVELIKSDNSMLNKIKINLPEGVENLGKCPQCGNPVIEGSKGYGCSNWKNGCKFTIWKNDKYIQSFGKKVTKDMVKILLEKGRVGFRNLKSKKGNVFTAYFTYENNKEKGYYSWKMHFIN
(557) DNA topoisomerase III-like protein [Clostridium perfringens str. 13]
3
MKKVIIAEKPSVARNIADAFNIKKRKDGYFEGEEYLITWAFGHLLQLFDAKDYDENMKGWRMEKFPFIPEVFKYKIKQDSLNRNIIDKGAEKQIKIIKGLIDREDVDGIISATDFDREGQVIADEIFLYFSEKKPVYRLLLNEWTPDEVKKGMEKLKPNEEMQSLQDAGIGRQWADWIIGINLTSVTTIKYKLNDGQILNIGRVLLPTLKIIYDRDKEIENFKSSAYYKLNGTFKTSKNEEFEGTYYENNSEKFEDKKVLDEIKEKIKDKNAEIIEKQTERKKEYPPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKFITYPRTGSMALEESLVDRTRNVLEKLKVGLPYEEQIKFVQNKRVFDNSKVESHSAIVPTYMKPNNLTQDERIVYTAVKNRFLMQFMPVAEFEETKITSKINDKEVKGVFISKGKVQLIEGWRVVEKIDSKDTILPMVNEKEIVDLVDSKINKVTKKPPKKHTEKTLLRVMETCGKSFKEDAEEDSEEMMASILSGFSIGTPATRAETIKKLKDVGYITTKGKSLTCTELGRTIVEIFPVKELLDLEYTGRLEKTLSDIERGKVKKEDFLNLIKNFTIEGVKAIKNDDSMAKHFKVEAPEGVEVLGKCPNCGNPVIEGERGFGCVNWKNGCKYTIWKNDKYIASFGKQVTPQMVKLLLANGKVGFRNLKSKKGNTFAAYFIYEKDEEKGYFTWKMEFI
(1152) DNA topoisomerase [Clostridium perfringens str. 13]
3
MKKLVIAEKPSLAMNIVKALNSSESFERKDGYFESENYIISFAFGHLFKLYNIEEYTGEDKGAKWRNDILPFIPKEFKFSIKDDVGVKKQYKILEELIKSNRVDEIVACGDADREGEVIIRLIINNVFNNNSINKKVTRLWLPEQTTQSILYGLNNLKDIDTYNNLANEGFTRTFLDWLVGVNLTRYVTVKSKHLFPVGRVLVPIVQAIYERDKSIENFVPETYYQIESNEKTNDEIIKLVVKELAFTKSEFIKAKSFADELNTYEAIVISKDTKKVKKQPSKLFSLSKLQSLLSKKYKMTFKESLELIQKLYEKGFVTYPRTNTEYLAEAEKGKVKEIIDILCSEGYNLEFKDKKTIFDDSKIESHSAITPTVKIPKEDELKGKMLDVYNTIKNRFISNFLIEETLIDRTIIRIEVGDLEFSLKGDVIVQKGFLEYEPIKKDENTLPNLNVGDKINTNFKAIEKVTQAPGKMTTEMLSNYLKNPFKNYEIENEEEDYKAILDGLEIGTEATRTGIIENAKKYKYISENKSVLSIEPLGRKLIETLDKLNVNLSKEKTVEFSRILKKVYKNELNIDRAVDLISNELKSILEDSKNIEIEAIKEEKEVIGKCPRCGKNIYETSKSFSCEGYKDEPKCQFNIWKEDKFFKDKGKKVTKSIAKNLLAGKKVKMTGLKKKDGNGTYDAFVSLNDTGKYVNYKLDFSK
(735) DNA topoisomerase [Clostridium saccharolyticum WM1]
7
MKLVLAEKPSVAMSLSKVIGANQRGDGYMEGNGYIVSWCVGHLVELSQPEAYDEKYAKWRYDDLPILPEHWQYQVSTSTKKQFGILKKLMLRKDVKSLICATDAGREGELIFRLVYHQCGCKKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCRERADWIVGINATRLFSCLYGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKFRDFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTSLQREANRQLGFTAQQTLDYTQALYEKKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSFQIQPDVPAPVNAAQVINSKKVTDHHAIIPTKTAAGHDISSLPSGEQAILIMLAVRLICAVGTPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGRSSEDAEKNAEACNLPELSEGMTLELAGVDLKEGKTSPPKRFTEDLLLSAMESASSDEFPAGVERKGIGTPATRAAIIEKLVQKGFIERRGDKKTKYLCSTDKGNALVTVVPEQIQSPSMTADWEEKLLKIEHGEYDSDAFMGEISSMVNGLVKTYEAVKGADVLMQPERKVIGSCPACGSDVCETVKGWFCRDKSCKFALWKENRFFQTLGKQMTEELAKQLVNQGKARLTHCYSRKSNRYYDTTVRVETGEDGAAAFKLEFGGKK
(89) DNA topoisomerase 1 [Clostridium saccharolyticum WM1]
1
MANCLVIVESPAKVKTIKKFLGANYEVDASNGHVRDLPKSQMGIDVENDFDPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLMKALKLDELKDKQVYRISFNEITKNAVKASLKTPRVIDMDLVDAQQARRVLDRMVGYMISPLLWAKVKRGLSAGRVQSVALRLICDREEEIGAFIPEEYWNLEAVLKQEGSKKPLIAKFYGDKDGKIPIRNKEELEKILAGLEKQTYQVEEIKNGERIKKAPIPFTTSTLQQEASKVLNFSTQKTMRLAQQLYEGVEVAGRGTVGLITYLRTDSTRIAEEADAAAREYIGKQYGGQYVANGEQQKKSNAKIQDAHEAIRPTDISLTPVMVKESLQRDLFRLYQLIWKRFTASRMQPAVYETTSVRVGAGKYLFTLSASRLSFDGFMSVYVQEDDKEEANVLLGNLEKGSFLKLDKLESGQHFTQPPAHFTEASLVKAMEEQGIGRPSTYAPTITTIIARRYVAKENKNLYVTELGEVVNRMMKKSFPSIVDITFTANLEYLLDKVGDGSVQWKTVVKNFYPDLKEAVDKALVELETVTIADEVTDEICEVCGRNMVIKYGPHGKFLACPGFPECKNTKPYLEKIGVPCPKCGKEVVIKKTKKGRIYYGCEANPECDFMSWQKPSTKTCPKCGAYMVEKGSKLLCSNEQCGYSTDK
(410) DNA topoisomerase 3 [Clostridium saccharolyticum WM1]
2
MKSLIIAEKPSVARDIARVLHCTKNHDGVIEGEAYVVTWGLGHLVTLADPEDYDPKYKEWKMEDLPMMPDQFRLEVIKQTGKQYRVVKAQIHRSDVGEIIIATDAGREGELVARLILEKAGNKKPIKRLWISSVTDKAIKEGFAKIKNGHEYDNLYDAAMCRAEADWLVGINATRALTCKYNASLSCGRVQTPTLAIIARREEEIKNFVPKPYYGISAKCADPALSFTWRDEKSKSFRSFDRDRVEALFNHRKAIGEGVITEVKSVPKKTEPPQLYDLTELQREANRRFNYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDIVPSIKERLEACGVGPYRKLAGRLANQKIKTAPSFVNDKKVTDHHAIIPTEQFVQLDHMTIEERKIYDLVVRRFLAVLYPPFEYEQTEITLDLGGETLAARGKTVKAQGWKEVYENQDEEEEEQELKEQNLPVMKKGDMINGLTVTMTEGKTKPPAPFQESTLLSAMENPVSYMETKDKDMAKTLGETGGLGTVATRADIIEKLFSGFLLEKRGKDIFLTSKARQLLTLVPEDLKKPELTAEWEMKLSEIAGGKLKRAAFMKDIRQYSGELIRQIKTGEGSFHHDNLTSHKCPVCGKRMLAVKGKNNEMLVCQDRECGHREVVSRTSNARCPVCHKKLELKGKGDSQIFVCKCGYKEKLSSFKERRAKEGAGVSKRDVAKYMSEQKKEGNQPMNSAFADAFAKLNLGDNGK
(1620) DNA topoisomerase [Clostridium saccharolyticum WM1]
7
MSKSLYIAEKPSVAQEFANALKANGRRRDGYMESDQVIITWCVGHLVTMSYPESYDPKYKRWSLSTLPFLPREFKYEVIPGVEKQFKIVSSLLNRPDVDTIYVCTDSGREGEYIYRLVAQMAGVKDKKQKRVWIDSQTEDEILRGIREAKDESDYDNLSASAYLRAKEDYLMGINFSRLLTLRYGQHISNYLKSGKNTVISVGRVMTCVMGMVVRREREIREFVKTPFYRVIGTFSKEDPSNPGLSGLDFDGEWRSAPGSRYYESPFLYKENGFKERQYAEELINALSLMDPMEGTVVSIEKKKETKNPPLLYNLAELQNDCSRMFKISPDETLKLVQELYEKKLVTYPRTDARVLSTAVAKEIYKNIGGLKSFTPLSEAAAEVMEKGSYRTIEKTRYVNDKQITDHYAIIPTGQGLASIKGLSSLGIRVYEVIARRFLSIFYPPAVYQKYALELAAESVYPGSEPTLQHQMTNKEHFYANFRVMLDAGYLKVAEVSWGKKKQEEGNGGTPSEETVQEENNPESSQNQMNNPLFVAMLGSLKKGMKLSLKKLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLFHIKYLSLNSKTQVIVPTLLGEMIFDVVNASIRQLLNPELTASWEKGLNYVAEGTITPGEYMEKLENFVAGRTAGVLRLNNHYDLHGVFDAAAANYKKPK
(287) DNA topoisomerase 1 [Thermoanaerobacter sp. X514]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNSGKFEAKFYGTREDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYTNPEANYASKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFLASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVQEFYEDFYNTLKIAEEQMEEIDVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPNCDFILWDKPVDEKCPVCGSLLVEKNTKNGHILKCSNPECDYQKEVK
(1276) DNA topoisomerase 1 [Clostridium botulinum A str. ATCC 19397]
1
MGQKMGQNLVIVESPAKAKTIKKYLGKNYVVEASMGHVRDLPKSQLGVDIENNYDPKYITIRGKGELLDKLRKEAKKSSKVYLATDPDREGEAISWHLAHVLKIDESEECRIEFNEITKTSIKKAIKSPRRINENVVDAQQARRVLDRLVGYKISPILWSKIKWGLSAGRVQSVALRMICDREREIEEFIPKEYWTIECEVYKEKNKKPFIIKLTTKSGKKIEINNEEEAIEAIQDLKKGEFIVKKIKKTKKNKNPLAPFTTSTLQQDSYKKLNFSTKKTMSIAQQLYEGIDIKGFGAVGLITYMRTDSIRISEEAQKSTLEHIKSNFGEEYIPKTPRVFKGKKNIQDAHEAIRPTNIEITPTLAKESLTPQQYKLYELIWKRFVASQMASCILDSTSISIENGKYGLRASGSLIAFDGFMKVYEYSTEEEKDSIKIPELEDNEILGEKSINKSQHFTQPPARYSEASLVKTLEENGIGRPSTYAPIISTILDRKYVEREKKTLKPTELGDIVNNILSEYFKQIVDLEFTADMENKLDYIEEGKKSWREVVNDFFQPLIESIEIAEKEIAKITIEDKVTDVVCEKCGRNMVIKHGRYGDFLACPGYPDCKNTKPIVEEIDVKCPKCRDGKVLIKKSRKGRKFYGCSNYPDCDFVSWSEPVKEKCEECGSYMVKKQSKAKGEYYECANSECKHRKYLNNKE
(236) DNA topoisomerase [Clostridium botulinum A str. ATCC 19397]
3
MSKLLLAEKPSVARNIGEALGCKTRKNGYLEGNGYIVTWAFGHLLTLYDCKDYDHKLALWSFQNFPYIPTEFKYKVKNDGKNRNVVDAGAKKQLEIIKELINRGDVEEIISATDYDREGELIALLIFNYLKANKPIYRILINEWTPTEIKKGLKDLKKNEEMISLQDAGVSRQLADWVIGINFTSIATMKYTRGKGNLLNIGRVLMPTLKIIYDREIEIKNFKVEEFYELEATFKNKKGEYKGKFFYEKKEKFPNKKIMEKLKAEIKDKSGLVTEKTIEIKKENPPSLFNLSNLQGYITSKYKGFTADKVLKVAQSLYEKKHITYPRTESTALEESIKDKAKKVLEVLKNDLPFKDEIIFNTSKKVFNNAKVESHSAIMPTYIIPKNLTPDERLVYDAIKNRFISQFMKEAQYENTEIVTTVPGENYERLFKTKGKILKCKGWLKLYKEKKKDELLPPIEKDDEVEIKSLKIISKKTKPPAHHTEKTLLKAMETCGKNTKQSEDNEEESNILYGYSIGTAATRAETINKLKYAGYITPKGKSLLITDKGTKLIETFPIRELLDTDYTGKLEKKLYDMEKGKFKKEDFLKEIFNFTVNGVNKIKNIRSNVICDTRVKKDK
(195) DNA topoisomerase 3 [Clostridium botulinum A str. ATCC 19397]
2
MGKVLVLAEKPSVGRDLAKVLKCNKKGNGYLEGNKYIVTWALGHLITLSDPESYDEKYKKWSMDTLPMLPKRMKTTVIKKTSKHFSEVRKVMIRKDVEELVIATDAGREGELVARWIIDKVGFKKPIKRLWISSQTDKAILDGFRNLKPGKNYENLYHSAVCRSEADWIVGLNVTRALTCRYNAQLSAGRVQTPTLAMIVQREEEIKNFKPRDYYSIEGKTKGFTMHWESAKGRFNTFDEDLAKKVVSKVTGKEGKIIEVTESDKKKYAPALYDLTELQRDANRIFGYSAKQTLSIMQRLYENHKILTYPRTDSRYISKDVVGTLKDRLKAISISNYSKFTNEILKGNIKAHKGFVDDSKVSDHHAIIPTEEKPKLGNLSGEERNIYDLVIKRFLSVMLPPFEYIQTTIKSEVIGEKFVARGKVIKSKGWKAVYDREEFDDKNNNSDSDDIKDQTLPKVNKGDGIKFSNFKINKGQTKPPARFNEGTLLSAMENPQRYINLDKESSKTLGETGGLGTVATRADIIEKLYNTFYIEKRGKEIVPTSKGKQVIDLVPKDLKSPLLTAKWERELDSISKGNLRGQIFINKMRDYSTKLVEDVKNSKDKYVHDNLTGKKCPQCGKYMLEVKGKNGVINVCQDRECGYRENVSRFTNVRCPECHVKLELRGEGQGQIYVCTRCSFREKLSSFNKKYRNNQEKLNKRDVTKYMKKMQKENDEPINSALAEALSKLKL
(1331) DNA topoisomerase 1 [Acetohalobium arabaticum DSM 5501]
1
MAENLVIVESPAKAKTINKFLGKGFNVEASMGHVIDLPKSQLGINIEENFEPKYITIRGKGDVLKKLRKAVKKSDNVFLATDPDREGEAISWHLSRALKLDDESECRIEFNEITENAIQQAIEAPRSIDKDRVDAQQARRLLDRLVGYKLSPLLWKKVRRGLSAGRVQSVAVKIICQREEEIEEFEPDEYWSLEADLQTDSKQQFEAKLHRIDGDKFKLNNKEETDKVIVEAEKNNFVIEKIKERKRRNNPAPPLTTSSLQQRAASSLNFTAKKTMFIAQQLYEGLDLGSEGTVGLITYIRTDSTRISKEAQQDTRKFIEDNFGPRYRPKDTKKYKVKSGAQDAHEAIRPTSVFRTPKKVKSYLNNDQYRLYKLIWEKFVASQMTPAIYKTLSVDIKAGKYLFRSTGSRTLFKGYLAVDTFKNRKQDKDLPEDLEEGTEVELLEFKPEQHFTKPPARYTEAKLVKTLEKKGIGRPSTYAPTVAKIQDRGYVNKEGKRFVPTELGKTVNHLLNKHFPDVTDIKFTANLEQQLDDVEVGKEDWRELLKEFYFPFEERLNSAYENMEEVELEKEVTDEVCEKCGKNMIVKHGKYGKFLACPGFPDCKNTKPYLIKMGVDCIECEDGEVVQRKSKKGRTFYGCSNYPDCEFMIWYKPVQEYCPECGTFLMEKTTKKRGTEYLCADEDCDFKTTPEELESEE
(693) DNA topoisomerase [Moorella thermoacetica ATCC 39073]
7
MVNACDAGREGELIFRRIYAWCKGQKPVKRLWLSEATPAAIKEAFRHLRVGEELDNLAAAAEARAQADWLVGINTTRAFTCRHNRLLSVGRVQTPTLALVVAREREIRAFKPEPYFEVWATFRKSTGETYRGKWFREKQDRLQDKKKAGDLAKQISACGIVEKIEQKEVREQPPQLFNLNDLQKEANKKYGLTAQKTLDAAQALYEKHKLLTYPRTDSRHLTTALVRDTLAGRLEALTGIPAYAALVPENLPQLGKRYVDDSKVSDHHALIPTAVNPDLSKLSPVEQKVYDLVARRFLAIFYPDARYAVTRVVTTAGGESFLSQGRVELERGWKAVYGRQEEDGAESKDEESQTLPQLVEGEEVAVQGVEVKAKQTRPPQRYTEATLLAAMENAGRLVEDKEMADTLKTAGGIGTPATRAAIIERLIQVGYLRREKKNLLPTAKGETLIGLVPEEVKSVELTARWEEGLKEIEEGQRDCKEWLEGIKNFTTEVVRMAREQEAAPGADPDREVLGQCPICGREVMEYPKSYSCSGYKEGCRFAIWKEIAGKKVTASQAKELLQKGKTGVIKGFKSKTGKKFDAALTLGEGGKVNFEFAEGNRETLGKCPLCGKDVTESQKGYGCSGWKEGCKFVIWKEIAGKKITAGQAKELLQKGRTGVIKGFKSRAGKEFEAILVLKEDGKLEFEFEG
(1288) DNA topoisomerase 1 [Moorella thermoacetica ATCC 39073]
1
MLAKTLVIVESPAKAKTIGKFLGKNYTIKPSMGHVRDLPKSQFGVDVENNFEPRYITIRGKGEIVKELRAAAQKAQRVLLAPDPDREGEAIAWHLQHLLGLPDEAIRIEFNEITRNAIQEAVKKPRKIDQDRVDAQQARRILDRVVGYRLSPLLWRKVRKGLSAGRVQSVAVRLIVDREQEIEAFQPEEYWSLTAWLLPENEGEAFPARLVKYAGEDLNVKNEGEMESILHSLEGTTYVVAEVKQRERRKNPAAPFTTSTLQQEAYRKLNFTSRRTMQVAQQLYEGIDLGGGQGPVGLITYIRTDSTRVASVAQLEARDFLMERFGSEYVPEGLRQYKGRKDIQDAHEAIRPTSVWREPASLKNILTRDQFRLYNLIWERFVASQMQAAVMDTVTVDITAGPCLFRATGSVVKFPGFLKVYQEGRDGEDKDQEQRLPPLATGQTLKLQSLEPKQHFTQPPPRYTEATLVKTMEELGIGRPSTYAPTIETILQRGYVTREQKQFVPTELGRVVVALLKEHFPKIIDVEFTAHMEEQLDAIEAGKISWRQVLAEFYGPFEEVLEKAEAEIGTVEVPEEVSEEKCELCGRNLVVKMGRYGKFLACPGFPECRFTKPLLETIGVNCPECGGQIVARRTKRGRKFYGCQNYPRCTYVSWDKPTNQTCPRCGKRLVEKASRQGSRLVCPQKECGYVEEVRQAK
(748) DNA topoisomerase 3 [Clostridium cellulolyticum H10]
2
MGFTLILAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLIGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFTVQWQDSRNNQTRTFNKEEADGIVAKITGQMGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKPSVTKRFVDNSKVTDHHAIIPTEQFVDLFSLNSEERNIYDLIVKRFIAVLSKPFEYEQTTVKLDIAGESFYAKGKIVKSSGWKTVYDGFGKLDEDDEDDNDQSLPDIQKGHKAKVVGPKSINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERKGKEIYPTSKGTQLISLVPTDLKSPELTAKWEQQLTLISKGKVNSNVFVNDMKKYARKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHICPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGQQVDKREVAKFMRQQEKDENINSALADALAKWKNN
(1178) DNA topoisomerase 1 [Clostridium cellulolyticum H10]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAIKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVRKGLSAGRVQSVATKMICDREDEIEKFESQEYWSIIAKLVKPKASPNFGAKFYGIGKEKLELTNEEQVNSILEEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGYTTKRTMMVAQQLYEGIEIKGRGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPEKPREYKNKSASQDAHEAIRPTYIDLPHEQIKEYLSPEQYKLYRLIWDRFISSQMSSAIYDTVSADITAGKYLFKANGSKVKFPGFMVLYTEGNDNEGKDEAEQDEKENKLPQLNEGDILELKENTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAEMESELDSVEDGDKEWKAVMRDFYSSFAGVLKKAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNAKPIVEEAGVECPICKGKVLIKKTKKGRKYIGCEKNPECPFMSWDMPSPNKEVCSVCGSFMLQKFSGKKKVLKCSNDKCTSNIEASKDNTK
(261) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-mouse-Japan]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVSVEDDYEPNYINVRGKADLIKSLKKASKKSEKVFLATDPDREGEAISWHLAYILGIDVDDKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINSFEVKQYFTIEGSGKKNSKKYVFKLHSKHKEKLDELTENKVLEILDELSEGKYIVDEIKEGSKNKYPSPPFTTSTLQQEAYKKLNFQTKRTMSVAQSLYEGVEVKGYGVVGLITYMRTDSVRLSADSLNQANEFVAKVYGDKYKLDIPRQYGKNNKNIQDAHEAIRPTNVEITPDIAKQTLKDDQYKLYSLIWRRFLASQMRNAVYNTMAISIKNGDYLFKLNGSQLQFDGFLKVYEVDKDDKDLILPAFEEGEELKNVKVESIEHFTQPPPRYTEASFVKLLEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIEFTADMEKKLDGIEEGKASWKSIVHEFYKPLKEKIDIAENTVKKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSIIQKLNIPCPKCGGEINVRKSKKGKVFYGCSKYPECDFISWNEPSNVKCPKCGGITVKKIKRKQEFYECIDQDCKDK
(1023) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-rat-Yit]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVNIEDDYEPNYINVRGKADLIKSLKKYSKKSEKVFLATDPDREGEAISWHLAYILGIDLSEKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINNFEVKQYFTIEGTGRKNSKKYVFKLHSKNKEKLDELTKDRVSEILDDLSKGKYVVDEVKEGIKNKYPLPPFTTSTLQQDAYKKLNFQTKKTMSVAQSLYEGVDIKGYGVVGLITYMRTDSVRLSSDSLNQANEFVKKVYGDKYKLDKPRQYGKNNKNIQDAHEAIRPTNVEITPEIAKQTLKDDQYKLYSLIWKRFLASQMANAVYNTMSISIKNNGYLFKLSGSQLKFDGFLKVYEIDKDDKDLILPIFEEGEELNNIKIESVEHFTQPPSRYTEASFVKLMEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIDFTADMEKKLDGIEEGKVDWKNIVHEFYKPLKEKIDIAENTVEKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSITQKLNVSCPKCGGEINVRKSKKGKVFYGCNNYPECDFVSWNEPSDVKCSRCGGITVKKIKRKQEVYECIDENCKE
(129) DNA topoisomerase 1 [Caldicellulosiruptor lactoaceticus 6A]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEVLKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVSCPKCSKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGGLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(810) Reverse gyrase [Caldicellulosiruptor lactoaceticus 6A]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEQCLSQEQISKNIFESLKKKGTLKDYQIYWNFQQNFDTFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEAFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFENLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILSELFNDLKNLIEN
(132) DNA topoisomerase 1 [Thermosediminibacter oceani DSM 16646]
1
MAKSLIIVESPAKAKTISRFLGKEYRVAASMGHVRDLPKSKLGIDIEKGFVPKYITIRGKGSIIENLRKEAAKAQKVLLATDPDREGEAISWHLAHLLDIPPETPCRVEFHEITKTAVSESLRHPRKINMNLVDAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSAAVRMICDREKEIAEFVPEEYWTIEAELADRPDGSSFKAKLHSRGNEKINLKNREQVEKIVADLQDQVFVVMEIKRGERRRNPAPPFTTSTMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGTVGLVTYIRTDSTRISEQAQKEAKEYIKANYGSEYVAESMSVKKAKKNIQDAHEGIRPTSVFRHPDSIKDSLTLDQYKLYKLIWERFLASQMAPAVYDTVSIDIKAGSYIFKASGSTLKFTGFMAVYIEGADEETEKDEGTLPILEQGQKLTLLKIMPEQHFTQPPPRFTEAMLVKALEEKGIGRPSTYAPIIDTIQKRGYVKKEKGRFKPTELGQLVTEILKEYFSDIVDLDFTAEMENQLDKIEAGEENWQKIIESFYRPFEEKLKIAEEKIEEVKIEDEVTEEKCELCGRNMVIKHGRYGKFMACSGFPECKNTKPLLEETGVKCPVCEGVIVVRKSKKGRKFYGCSNYPNCEFVTWDPPSETPCPRCGGLMVVKSTKSGKITACTNTECGYKDQVEG
(1032) DNA topoisomerase 1 [Peptoclostridium difficile 630]
1
MAKTLVIVESPAKAKTIEKFLGKSHYTVKASVGHVRDLPKSKLGVDIENNFEPQYINIRGKGDVIKELKKEAKKSKQVYLATDPDREGEAISWHLAHILNLDESEDCRIEFNEITKDAIKKAIKHPRNIDINLVDAQQARRVLDRLLGYQISPILWQKVRKGLSAGRVQSVTTKLICDREKEIKAFIPKEYWTIDVEAKTVKDKDITLKFYGKNDEKIELENEEAVNEILKEMEGKDLKVEKIESKSRRKSAPKPFTTSMLQQEGANKLFFTTKKTMMIAQELYEGIDIEGEGTVGLISYIRTDSKRISDEAKEKAKGYIVNNLGENYYKNTGDKKEKKDTKKVQDAHEAIRPTSVDRTPESIKASLSKDQYKLYNLIWRRFVASQMEDSVFDILNVECKIGDIVFKATGSKMKFDGYTKVYNFSEREDKILPSIEKGDILNIENILPDQHFTQPPARYTEASLVKTLEELGIGRPSTYAPTIATILNREYVEKQGTSLCPTELGIIVTDILENNFHKFIDVDFTADMESKLDVIEEGNTDWKKIVSESYAPLKEAIEEALENIEKVNMDEETDEICENCGSNMVIKYGRFGKFMACKNYPDCKTTRPIMNKIGVKCPKCEEGDIILRKSKRGKAFYGCSNYPNCDFVAWNKPTGEFCEKCGSYMVEKVTKSETKTVCSNKECNKETKEHNDGKE
(28) DNA topoisomerase [Peptoclostridium difficile 630]
7
MKLVIAEKPSVAISIAKVIGATKKKDGYYEGNGYKVSWCVGHLIQMANPESYDEKYAKWNMADLPIIPREYKYEIAKSTKKQFTILKKLMNDKEIDIVINACDAGREGEAIFRLVYNQANCKKKMKRLWISSMEDSAIKEGFDNLKDGSFYDNLFESAQARAIADWLVGMNLSRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEIANFKKEKYFTVELDLDGFSLSTDRIDDKTVTEQLINLLGNSIEITDVIQKEKITKPELPFDLTTLQRECNKYFNYSAKQTLDYTQSLYEKKLITYPRTDSRYLTEDMITSTINNIVGKHDFDTGRIKMVFNSKRVTDHHAIIPTASSMNEDLASLPESELKVYELVLNKLHASVGYPLIENTTKIVAVFDGFEFTSSGKVIVDEGFTKYLKKYIKKKNEDTVFPDLKIGDSLDIKEKEIKENYTSPAKHFTEDTLLKDMELAGNDALEKGVEVERKGLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVSDTFKSAGTTAKWEMELSDIAQGKASKENFLKAIENEIKELVSTYSK
(573) DNA topoisomerase [Peptoclostridium difficile 630]
7
MILVIAEKPSVAQTIAAVLGVKEKKDGFLTGSGYIVSWCVGHLVGLAEAAAYGEQYKKWNYDSLPILPQEWKYTVAADKEKQFKTLKELMHRADVSEVVNACDAGREGELIFRFVYEMAGCKKPMRRLWISSMEDSAIKEGFSRLKNGKEYDALFASALCRAKADWLIGINATRLFSVLYNHTLNVGRVQTPTLKMLVDRDAAITTFKKEKYYHVRLALSGAEAASERISNKAEADTLKTTCEASKAVCTSLLKEKKTAAPPKLFDLTSLQREANCLFGYTAKQTLDLAQALYEKRLLTYPRTDSSYLTDDMGDTAAGIIKLLCGKFPFMAGKDFTPELAKVLNSKKVSDHHAIIPTMELAKTDLAALPESERNILTIAGARLIMATAAPHTFEAVTAVFECAGQSFTARGKTVLSDGWKEIDRKYRAILKSKPETDDADSDTEKTLPPFTEGQNFDNPAAKVTEHDTTPPKPHNEASLLSAMERAGSEDTDPDAERKGLGTPATRAAVIEKLVKGGFVERKGKQLLPTKDGINLVCVLPDTLTSPQLTAEWENNLTQIAKGKADPAAFMKGIEDMARELVKTYPFLSEADKGRFKEEKPELGKCPRCGSPVYEGKKNYYCSNKECSFTMWKNDRFFEERKVTFTPKIAAALLKSGKVNVKKLYSPKTGKTYDGTIALADTGEKYVNYRIELSKKK
(1711) DNA topoisomerase [Peptoclostridium difficile 630]
7
MKLVIAEKPSVAISIAKVIGVNKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYAKWNMADLPIIPSAYKYEVAKATKKQFNILKKLMNDKEIDTVINACDAGREGESIFRLVYNEAKCKKKMKRLWISSMEDSAIKEGFDNLKDGKGYDNLFESAQARAIADWLVGMNISRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVELSMNGFTLSTDRIDDEVAAEQLINLVGDKIEITDVIQKEKITNPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYPRTDSRCLTEDMITSTINNILGKNDFDTGRIKTVFNSKKVTDHHAIIPTISSLKEDVSKLPLSEAKVYFLISDKFHASVGYPLIENTTKIVASFDGFEFTSSGKVIKDEGFSKYLKEYKSKKNEDAVLPNVSVGDVLSIENKEIKEKFTKPPKHFTEDTLLKSMEIAGNDALEKGVEVERKGLGTPATRAGIIENLIYKGFVERDKKNLIATHKGISLVTIVADNFKSAETTAKWEMELSDIAQGKSSKKEFLDAIENEIKEAVLTYRK
(918) DNA topoisomerase [Peptoclostridium difficile 630]
3
MKLVLAEKPSVAKTIASFLGAKTRQDGYFEGNDYIITYAVGHLVSLYDMKDYDKDKYSGSWKMNNFPFVPEDKFKFKIDSSKTKQFNTVKKLLNRKDVEYVINATDNDREGELIAFLIFLLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAAGYTRLITDWLIGINFTSVATLKYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYYEIEGHFKAEAGEYKGKYVKGKESKFDTLEDANKIIASITSETGKILDKKVTMSKEYAPKLFSLTSLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASKASQTLDKLKVGLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYIIPKSLSKDEQLVYDAIKDRFVANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKNDLLPLVNKDDVVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDTTVLSGYSIGTSATRADVLKKISQVGYVKKKGKSYSITELGKNLVEIFPVKDLFDVDYTGKLEKSLSDIQKGKYTRKEYLTNIISFIYQNVNIIKQDASKNINTEAYTFDSKTKKFTKTKEKKQKKDVTNTEKEVAISKDSNNKKEVKNGDENQSLGKCPICQGDVLEFDKGFACKNHKECKFVIWKNDKYLSLYKKKVNKTMVKNILKKGETKVKSLTAKNGNKFDATLKYDKNPDTGYFNWKIEFDN
(1879) DNA topoisomerase 3 [Peptoclostridium difficile 630]
2
MGKILVLAEKPSVGRDIAKVLGSKNEKNGYIEGPKYVITWALGHLVTLADPESYGERYKSWSLEDLPILPKHLKTVVIKKSGKQFNTVKSQMNRNDIDEIVIATDAGREGELVARWIIEKSQVKKPIKRLWISSSTDKAIKDGFAKLKSGKEYENLYYSAIARAEADWIIGINATRALTTKYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLELIATKGNSDIKFIWNDKNNNSSTFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPALYDLTELQRDANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIKAVNISDYSKICNRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVFMSDFSDKERKIYNLVVKRFLAVLSPPFEYEQTTISATVEGEIFKAKGNKVINLGWKESYKDIEDEDEYESIPNVLEKDVLKVKGLKITSGKTNPPPYLNEGTLLTAMEKNGLGTVATRADIIEKLFNSFLMEKKNKDIYITSKGRQLLDLVPVDLKTPELTASWEKKLLDISKGKLSKNTFINDMKDYSKDIVLEVKNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLICEDRECNTRKTISQVTNSRCPNCHKKLELRGEGEGRIFTCSCGYREKLSSFNKRKQEEKQKASKKDVNQYLKNQNKNQETFNNPFAEALAKLKNK
(1084) DNA topoisomerase 1 [Thermoanaerobacterium xylanolyticum LX-11]
1
MEKSLVIVESPSKAKTIHKYLGKNYKVEASMGHIRDLPKSQLGIDIEKNFEPKYITIRGKGPIIEKLKKEAKNASKIYLATDPDREGEAISWHLASLLNIDINEKCRIEFHEITKNAIQNAIKNPREINMNLVDAQQARRILDRLVGYNISPLLWKKIKRGLSAGRVQSVATRLICDREKEIEDFKPEEYWSISAYLYKEKKTQSFEAKFYGTKDGKVELKNENDVNEIVKDLTDDYVVENVKIGTKKRNPSPPFITSTMQQEASKTLGFTAKKTMMIAQQLYEGVEIKGEGSLGLITYMRTDSTRVSDEAKKAAYEYILQKYGKEYANPNATYAKKGGNIQDAHEAIRPTYIDLDPEKIKDSLKPDQYKLYKLIWSRFLASQMSPALYDTMNVDIINKNYVFKASGSKIKFSGFMAVYTDDDENENEDKMLPMLNSGDFLKLKELKPEQHFTQPPARYTEATLIKELEEKGIGRPSTYAPIISTLLERGYVIKEKKNLKPTELGFIVTDVMKEFFPDIVDVKFTAQMEEQLDRIEEGIEKWCDVIDEFYNGFNASLKIAEEQMKDIEIKDEETDIKCEFCGRNMVIKYGRYGKFLACPGFPECKNTKPLYEEIGVTCPKCGGKIIIKKSKKGKVYYACENSSNCGTMFWDRPISETCPKCGALLVEKHSKGRKIIKCSNCDYVK
(292) DNA topoisomerase 3 [Coprococcus catus GD/7]
2
MKTLVIAEKPSVGRDIARVLQCTRNSQGALEGEKYIVTWALGHLVTLADPEGYDAKYKSWRGEDLPMMPQHFKLVVIKQTHRQFQIVKNQLLRKDVGTIVIATDAGREGELVARWILKIAGNKKPVKRLWISSVTDKAIREGFKNLKDGRAYLNLYAAAEARAEADWLVGMNGTRALTCRYNAQLSCGRVQTPTLALIASREQEIKSFVPKKYYTLTTVSHGMTWNWQDGKSGSNRSFDRGRIQSIAEKAEKDEMVITDVQRTVKKSYSPGLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYIGKDVAETLKERLQACAVGPYRKVAGKLLLQPIRMDKRFVDDSKVSDHHAIIPTEQFVQLDHMSSEERKIYDLVVRRFLAVLYPPCEYEQIKLTGSCAGEKWTAGSRMMKEAGWQQAYESEWEEEDDDSLMTVTSMPKLEKGRKDTVMRPKVSEGQTKPPAYYNEGTLLTAMEKGNLGTVATRADIIDKLFNSFLMEKKDKDIRVTSKGRQLLGLVPEDLKKPELTADWEKKLLAISEGRLKKDVFISEIRGYTEEIVKEIAGGEGQFRHENLTNHLCPNCGKRMLSVQGKNSKMLVCQDRSCGYRESIARKTNARCPKCHKKMEMYGKGDAQTFVCTCGYKEKLSAFQNRRKKEGAGVSKRDVQQYMKRQQKEANEPINNAFAAAFAKLNLETKEGE
(1278) DNA topoisomerase [Coprococcus catus GD/7]
7
MYLVIAEKPSVSKAIAEVIGAQEREDGYLQGTDCMVSWCFGHLAEYVSPDAYDEKFNQWRYEDLPIIPKDWKVTVSEDKKDQFYILKRLLNSPEIEYVVNACDAGREGELIFKHVYDLSGSKKPVKRLWISSLEDSAILDGMQHLRSAEEYRHLAEAAVCRSQADWLVGMNATRAYTTKYFKKLTVGRVQTPTLAMLVERAGQISNFQKEKYFNVELDCDGIPAVKPKIFDPDEAEQLRSRCQGSEAIVTAVKETEKKVKAPKLYDLTTLQREANRIYGMTAKQTLDTAQSLYEKKLITYPRTDSQYLTEDMEQTARNVVRQIYEKYQLTGPFDQPEQPDVKKVMNNSKVTDHHAIIPTMELASCHLDELKSWEEKILFLIAVHTVMAMSKDHIYQETEIEVECQEEIFKAKGKIVLQDGWKLFENCFKNKDRMAIVDPDQEMKERMPKVTQGQTFYAVDAEKTEHFTSPPKPYSEDTLLAAMETAGNKEFDEDTEKKGLGTPATRAGIIEKLVYSQYATRKGKQIIPTDDGKVLVEILPDFLKSASMTAEWENQLLLMEHGEIAPEQFMTGIKNMLTMMLNGCDAISEEETRRFQTRESIGTCPVCGSLVYESKTNFYCSNHDCHFALWKDNRYLQSMEKNMDKKMAAELLKSGCVHVKDLYSRKKNMYFEADLHMDADETGRVKFSLSFPKKKPKNKSKKK
(1772) DNA topoisomerase 3 [Clostridium lentocellum DSM 5427]
2
MGKILVFAEKPSVGKDIARVLKCTQKQNGFFEGPKYVVTWAMGHLVGLSDPEAYGNQYKTWSMETLPMLPERMKLTVLKGTGKQFQIVKSLMLRKDIDEIIIATDAGREGELVARWTIDKVGVKKPIKRLWISSVTDKAISEGFKNLKPGKDYENLYKAAVCRAEGDWLVGLNVTRALTCKFNAQLSAGRVQSATLAMIVAREEAIKNFQPKPYFTLSAKCKGIQLAYKGKKGDRFFDEKQIVTLIGKLEGSKAQVTEYKETSKKQYAPALYDLTELQRDANKRFGFSPKETLSVMQRLYENYKVLTYPRTDSRFLSEDIVPTLKERINAIAIGPYKVGAREVLKNGIKSSKHFVDNSKVSDHHAIIPTEESPDLSKLNSDERKIYDLVVKRFLSVLLPPMAYNEGVLEVSSEGECFVAKGKKVIEPGWKMLYEIEADEDEDEVVQSLPEVKKGETVVLEQFFKTKQMTKAPSRFTEATLLSAMEKPHQYVEVDQKAAKTLGETGGIGTVATRADIIEKLYNMFYIEKSGKEIVPTSKGKQLIELVPVDLKSPLLTAEWEMALEQISKGKQDPKAFMKKIRVYSEELVQSVKGSGEKYIHDNLTGKRCPECNKLMLEVKGKHGKLYVCQDRNCGYRENISRFTQTRCPNCHKKLELRGEGEGQIYVCTTCTFREKLSVFNKKYRSESKKVDKKSVQKYLKEQTKKEEGNFAFAEAFAKLNK
(1795) DNA topoisomerase [Clostridium lentocellum DSM 5427]
3
MKKVIIAEKPSVAKNIADAFDIKTKRDGYYEGEDYLITWAFGHLLQLYDAKDYDESMKSWRLEKFPFIPEEFKYKVKSDGKNKAIEDVGARKQLNIIKDLIDREDVESVISATDFDREGQVIGDEIFLYFNEKKPIYRILLNEWTPEEVKKGISQLRPNEEMKSLQDAGIGRQWADWMIGINLTSVATVKYNSGSKKILNIGRVLLPTLKIIYDRDKEIEQFEASTYYKLLANFKTSQDEVFEGTYYEKDEEGKDNEKFDNKATLESMVELIKNKPAQIVEKQVEKKKEYAPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKYITYPRTGSLALEESLKGRTKKVLDTLKIGLPYEGQICFADHKRIFDNSKVESHSAIVPTYIIPKSLTPDEQVVYNAVKNRFLMQFLPIAEFEETKLITKIIDVPEESLKGVFISKGKVQLVEGWRIVEKFEAKGTKEGKENKDTLLPQVTQDELVEMKNANVAEVTRKPPKAHTEKTLLRVMETCGKSFKGDEKEEGKEESEEDTLKMMASILSGFSIGTPATRAETIKKLKDAEYIRAKGKSLVCTDLGKALVETFPAKQLLDLEYTGRLEKTLSDIEKGKFQKDEFLSMIKAFTEEAVEAIKNDTRVLSGTKVEVPKNMEPVGVCPVCGNAVVENEKAFGCVNWKSGCKYTIWKNDKYITMLGKNVTRQMVELLLKNGKVGFRNLKGRNGNTYAAYLKYVKNDQTGYFNWEQEFI
(440) DNA topoisomerase 1 [Clostridium lentocellum DSM 5427]
1
MADNLVIVESAAKVNTISRFLGKNYKVEASIGHVRDLPKSQLGVDTANNYEPKYITIRGKGELLQKLRKDVKNAKCVYLATDPDREGEAISWHLYHALKLQEKKVCRITFNEITEQAVKEAIKHPRDINTDLVDAQQARRVLDRLVGYEISPILWKKVRKGLSAGRVQSVTLRLISDRDKQIREFVEEEYWSITANLQQGKGKTFEAKLDTYKNEKCDINNEEEAKKIVKACKKGHFQVVSSKKGTRVKNTVLPFTTSTLQQEAAKHLGFSTQKTMNIAQQLYEGIKVGKKEVGVVTYIRTDSIRIADKAKEEATTYITQKYGEQYLGAKKQIEKAKKAHIQDAHEAIRPTYMEYEPNEIKEYLSRDQFRLYQLIWNRFVASQMAPAQYETYSIKVQNGDYEFKASYSIELFDGFIKVYNLGEEKAKKEAKFQVEEGEQLVCGSIIPNQHFTQPPAHFSEATLVKTLEENGVGRPSTYAPTITTLLARGYIVKESKILYMTELGEVVNQIMKEYFDEVVDVDFTANMERILDEIASGNVEWKEIIKSFYPHFHHTVEYAESQIENIDLTEHTDIPCEKCGTHMVVRYGKYGKFLGCPNFPECNGTKPWYEETGISCPECNGKILMKKTKKGRSYYGCEHNGEGCEFMSWDKPTGEKCPICGEALIEKGNSKNKKIVCRNSKCNYGKQNKN
(906) DNA topoisomerase 1 [Coprococcus sp. ART55/1]
1
MIRITGNLQKGQIAMAKNLVIVESPAKAKTIKKFLGSNYEVIASNGHVRDLPKSQMGIDVDNDFEPKYITIRGKGDILAALRKAVKKADKIYLATDPDREGEAISYHLMKALKLENKDYKRITFNEITKNAVKNSIKQARDIDMNLVDAQQARRVLDRLVGYKISPVLWAKIKRGLSAGRVQSVALKLVCDREKEINDFIPQEYWTLDANLTGGKLKKPITFKFTGDGKNKEEISGRAALDEILSGLQDGEYVVKSIKESERNKKAPLPFTTSTLQQEASSKLNFATSKTMRIAQQLYEGVDIKGRGTIGLITYLRTDSTRISEEAVAAADKYITDNFGEIYIGDSNGRAKTDKKIQDAHEAIRPTDVTLSPVMVKEQLSRDQFRLYQLIYNRFLASQMAGAVYSVKSVKVSCGDATFQTSASKIAFDGFLAVYNLDNDRGETVAGINNLAEGDVLELDGFEEKQHFTQPPARYTEALLVKTLEELGIGRPSTYAPTISTILARRYITKEQKKLYVTAIGDAVNQSMEQAFPVIIDVNFTANMESLLDKIGEGTVDWKVVVRNFYPDLDEAVKKAEAELESIKIEDEVSEEVCDVCGRNMVIKYGPHGKFLACPGFPECRFTKPFYEKIGVTCPKCGGDVVIKTTRKGRRYYGCINAPECDFMSWAMPSNEKCPECGKYMIVKGNKLVCSDQECGYTCNNKAAETADK
(460) DNA topoisomerase III, bacteria and conjugative plasmid [Coprococcus sp. ART55/1]
7
MQLVIAEKPSVAKSIADVLGALDRQDGYFEGGGYLVSWCVGHLIELAEPESYGEQWKKWTYESLPVNPEHWQYEIKEDTKEQYDVLYGLLHDSRVDEVVCATDAGREGELIFRLVYNMASCKKPMKRLWISSMEESAIREGVENLKPGSDYDHLYHSALCRQEADWLVGINGTRLFTVLYGGKVLKVGRVQTPTLAMLVEREAKIMNFKKEQYFMAHILCGGVDAVTERIDNKTEAENVAGACRNGQALVTSVEKEEKTVSPPKLYDLTTLQRDANRLFGFTAKQTLEYTQSLYEKKMCTYPRTDSQYLSDDMEQTAGNVIEAIFSSILFEENRMFNPDIKRVLNSKKVTDHHAIIPTMEIAKADLAALPETERKILSLVANRLLCATGEKHLYETVKAELSCGGYTFTTSGKSVLKNGWKDFEDAFKRSFKATEEKEQEDKKLPELSEGQTFDGVQTKISEHYTTPPKHFTEDSLLSAMERAGNEDMSDDVERKGLGTPATRADIIEKLVKDGFVKREKKQMLPTEDGMKLITVLPDVVKSSKLTADWENALTLVAKGEMEREDFMADIETMESDLIHTYHEVSDEQKKMFAQEQKVLGKCPNCGGEVVKGKYGAFCKNKCGMNVSRIMGVALSDEQVESLLAGKKTLLKGITSKAGKKYDAYIIPSGTEEYHYTKDGEEKSGAQFKFVMEFPNKKFTGKKK
(285) DNA topoisomerase 3 [Ruminococcus sp. SR1/5]
2
MKSLVIAEKPSVARDIARVLHCSQKGNGTLEGKAYVVTWALGHLVTLADPEEYDKKYTKWELSTLPMMPEKMKLVVIRQTSKQYNAVKTQLYRKDIGEIIIATDAGREGELVARWILAKADCHKPIKRLWISSVTDKAIRDGFAHLKNGHDYDDLYRAAQARAEADWLVGMNGTRALTCKYNAQLSCGRVQTPTLAMIARREQEIREFKPEDYYGIILQAGNVRWTWRDGKSGSLRTFKKERAQEIQTKAGKSSLTITKVSRKPKKTYAPGLYDLTTLQREANQKYGFSAKETLNIMQRLYENHKVLTYPRTDSRYIGKDVVPTIKERLQACGTGPYRKLAGALVNKPIQTSAGFVDDKKVSDHHAIIPTEQFVQLDHMTNEERKIYDMVVRRFLSVLYPPAVYELVSMEGTAAGETFAASGRIVKSAGWREVYEGGWQDEDEEESGDKLKDQKLPELTEGQILTVEGAALTAGKTKPPARFTEATLLGAMENPVHFMESHDKKAAKTLGETGGLGTVATRADIIEKLFNSFMMEKRGNEIYITSKAKQLLELVPEELKKPELTADWEMKLSDIANGKLRQDKFLTGIRKYACEIVDEIKGGQGTFRHDNMTNKKCPNCGKHLLAVNGKNAKMLVCEDRECGYRETVSRTTNARCPKCHKRMEMLLKGKEETFVCQCGYKEKLSSFQARRAKEGAGVNKRDVQRYLKKQQKEANEPVNNAFAQALSGIKLD
(1434) DNA topoisomerase 1 [Acetobacterium woodii DSM 1030]
1
MIKTLVIVESPAKAKTIKKYLPKGFEVEATMGHVIDLPKSRIGINIENNFAPEYIKIRGKAALLKSLKSAAKKADQVYLATDPDREGEAISWHMANFLEIDLTTKCRIEFHEVTKKAVNAAIENKREIDIDLVNSQQARRILDRLVGYSLSPFLWKKVKKGLSGGRVQSVVTRIIVDREEEIEAFIPEEYWNLELLLKKTDDPIEFISKFYSEDGKKKTITIAEEAQRLEKIVDANAIIVDKVKKRIRYQKPPVPFTTSTLQQEAYKVLGYTTQRTMRLAQQLYEGVEIKGSGLTGLITYLRTDSTRIADEAVLESKAYIKQHFGDEYLGSEKKVGKKKNVQDAHEAIRPSSIMLTPEKAKESLEPDQYRLYKLIWERLLCSQMSDAQYYVTDVDIACNNLIFKTKGETQKFDGFTRVNRNPNKSEDSILPELSVGDDLIRLKTTKEQKYTKPPARYTEASLVKILEEKGIGRPSTYAPTIATIKNRDYVEVIEKHFKPTELGVTVTHLMKEYFSDVVNISFTADMEDRLDSVSEGKTDWVELLRNFYGDFEKALTNAQEKAEAVTIADPESDEDCELCGRRMVIKKGKYGRFLACPGFPECKNTKPFFEKTGGICSLCGGDIVKRTSKTGRTFYSCNNYPDCDYMNWDMPIPEKCPVCGSTLFQKGLGKRKSIYCDKKDCGYKAAPKE
(1351) DNA topoisomerase [Desulfosporosinus orientis DSM 765]
7
MKRTLIVAEKPSQAREYAVALGVKRKGDGYLENDQYVITWCYGHLLELERPEAYMDLEQVGRRWSLRRLPVLPSLNDFRRVVKKESAKQYQVVLNWLSSSEITQVICGTDADREGQLLFQEIWDAANCRKPLSRLWISSLTTAAIREGLKNLRSAETVAGLAAAGNGRAFADWDFGMNLTEGFTALFGSFDTERKRPNVISIGRVQTPTLALIVEREWEIESFVPQQFYEVKAEFKAEQGNYYGKWIDPGDDTKRITDLQEAESIVLKTQGKLGSISEMEEKEILEPAPLLFDLTSLTIAGSKKYGYSAEKVLQLAQSLYEKKAITYPRTDCAYLSEDILPKLPAHLNAVCQEPYKDLADQARGFGLPKGKRVINTITAHHAIIPTTEKVVLERLNRDEQHLYDLIVRRFLAVWFPPARYYQTVVMTLVESETFRTKGKALLSLGWKAVYDHSDLKKHGSAGEEEEAALPPLLKGQVVQVKEVSWDEKSTKPPKPYTQGDLLKAMEGAGKQIDDEILRQQLKGKGLGTVATRPAIIESLIDRGYIFQKQKSLRPSAKGVELIRLIKEKLPEAHLLISAEMTGQMEYNLAKVEKGEIPIQSYMSEVENSVKRIVAELRSFEQCHGKSPLAFAPAVKVSRKGKKKEEGEKTVRQKEKTSDSSAQSLGKCPKCGSEVIEGQKGFGCSNWRSGCRFVLWKTPICGKTLTPNQIRRLLKTGKTPLIKGFKSKSGQSFAAYLIWENPAEAKLTFRFKKE
(1694) DNA topoisomerase 1 [Desulfosporosinus orientis DSM 765]
1
MSKTLVIVESPAKAKSISKFLGSRYTVKASMGHLRDLPKSQMGVDLENDFEPKYIAIRGRGDLIKELRAAAKSADRVFLASDPDREGEAIAWHLSYLLGLEQTDKIRIEFHEITKQAIQTAIKHSRHIDQDRVDAQQARRVLDRLVGYQLSPLLWRKIKKGLSAGRVQSVAVRLIDDREEEIRAFVSEEYWSLTAELQFAGGKFLAKLVKKSGKKISISNRTEMETVLEELKGKEFKVSDVRTKEKKRLPAPPFTTSSLQQEAHRKLGFSPKRTMMLAQQLYEGLDLGKEGTVGLITYMRTDSVKIADIAQTEAKEWILGNYGGDYYPPEPRQFTTKGRAQEAHEAIRPTLPLRTPDALKGILSRDQLRLYRLIWERFMASQMSVAVVDTLTVESLVDEYLFRANASTVRFPGFLAIYEEGNDDTEAKDEEQNSLTISVSPGEQLKLIKLQEKQHFTEPPPRYTEASLVRKMEEEGIGRPSTYAPTIETIQTRGYVVKEEKQLLLTELGDIVITLLKEHFPDIVNLEFTANLEEKLDLIEEGKAPWKAVVEEYYQPFSVTLAEAEEKIGKVKIEDQVSEEICENCGRNMVIKMGRYGKFLACPGFPECRNTKPLFEEVGTPCPNCSKPLVVRRSKKGRKFYGCLGYPECDFVSWEMPAPEPCPECGQLMVVKSTKRQKKHVCTNRECRHTIVIEEEG
(1129) DNA topoisomerase 3 [Desulfosporosinus orientis DSM 765]
2
MGKTLVLTEKPSVGREVARILHCNQKGKGCFIGPNYVVVWALGHLVTLADPELYDEKYKDWKMEDLPMLPDKMELVVMKETAKQFGVVKNLMRSQEFSDLIIATDAGREGELVARWIIKKAGWKKPLKRLWISSLTERAIKEGFQHLKPGKEYEALYAAAECRAEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREQEIKNFVPKDYWTINLRARGFNLRWQDSNGQTRIFAKEKAEALAAKLKGHSGEVVEVKRDAKKELPPLAYDLTELQRDANRKYGFSAKTTSSVMQQLYENHKLVTYPRTDSRYISEDMVSTLPERLKSIALGPYVNLARGILRNKPIVTKRFVDGSKVSDHHAIIPTEQPPALSRLNSEELKIYDLIVKRFLAVLSAPFEYEQTLVKVAVQKEVFTAKGKIVKKLGWRSVYEGQGTWDDDSDDGEKEAEQTLPEISRGEILSNLSVDLASGKTKPPSRHTEATLLSAMEHPGKLIGDQKLREAMEQSHGLGTPATRAEIIEKLYNSFYMSRQGKEIVPTSKGIQLIGLVPAELKSPVLTAKWEQQLTEISKGKVNSQAFLKGIRGYTIQLVSTVSGSTQTFKHDNLTRNKCPECGKYLLQVKDKKGEMLVCQDRECGYRKRLTQISNARCPECHKKLELKGDGENKFFSCVCGYREKLSVFTKRREAEKGKMNKKDVSRYLHNQKDDGPINTALADALAKFKKQQ
(1714) DNA topoisomerase 1 [Eubacterium limosum KIST612]
1
MAKNLVIVESPAKAKTIKKYLPKGYEVQATMGHVIDLPKSRIGIDIEDHFKPDYIKIRGKGELLKKIKKEANKADNVLLATDPDREGEAISWHVANFLGIDLDTKCRIEFHEITKRAVNAAIENKRAVDMDLVDSQQARRILDRLVGYSLSPFLWKKVKKGLSGGRVQSVVTRIIVDREEEIAAFVPEEYWGLDLELKKDKDKNIFLSRFYSEDGKKKTIKNAEEAARLEQVVLHNPITVAGVKKRVRKQKPPLPFTTSTLQQEAYKVLGFTTQRTMRIAQQLYEGVEVAGKGLVGLISYIRTDSTRLADEAIAEAKDFIETNYGPDYQQSSAKKTVKKKNVQDAHEGIRPSSVFNLPEEVRDSLEKDQYKLYKLIWDRMVASQMADAEYYVTDVDVACANLLFKTKGEIMKFKGFTAVYRTASSAEKEEANRLPEFEDNEELNLVKINKEQKFTKPPARYTEASLVKILEEKGIGRPSTYAPTIATIKSRDYVEVVEKHFVPTELGITVTHLMKEYFEDIVNLTFTAEMEEKLDKVADGETDWVKLLESFYGGFKKELDHAQEAAAEVTIADPESDEICELCGRRMVIKKGKYGKFLACPGFPDCKNTKPYFEKTGGICPECGGDLVKRTSKKGRTFYSCSNYPNCEYMSWDMPVAEKCPECGQTMFQKGLGKRKKVYCAKCGFEKSADQQ
(423) DNA topoisomerase [Eubacterium limosum KIST612]
3
MKDLILAEKPTVAVNIAKAVGMTSRKDGYFENSQYVITFAVGHLLELYDVKDYHPEYGEKWEISHYPFVPDTFKYKIAESTRKQFKIVKDLILSDEIQEIISATDNDREGQLIADLIFRYLGVKKPIRRLITNEWTTDAIRYGLKNTVPNKSKQSLFYAGLVRQQMDWLLGINLTSVATLKLLKNGTGKDTLHIGRVILPTLKLVYDREMNVKNFKSIPIYYLNAYVKDVSGEEIIFRYIEGDEKIYKFDHDSHLVQILRLINTETAVVVGYECSEKKMNPQRLFSLPTLQGHITTKYEGWSSDKVLKIAQKLYENKLITYPRTDSVYLDETLKENMSMVLNIHKIESQYAEMLQFKDTKRIFNSEKVESHSAITITKEKPRGLSQDEHIVYEAIRNRFLEQFMPLAIDEEVEVTLAFEGKVPSEDGAFLFSAKSIVERSPGWRLIENRNATKKETLLTRMRENESVTIDRVMVNKGETKPNPLHTEETLIKAMLQCGKKYKTEDELETSILSGFTIGASSSRAAVIKKLFDSDYVIKKGKSLVTTDRGKSLIQAFPVKSLFNVETTGKMEMRLKDIEEGKADPRAYLEDVKIKTKEYVQMILETEQFVLNAGEDISIKELRCPKCGKPLHKTKSGVGCTGYEKEGNGCDFFIANPFAGKTLSNRQIALLVINKKTPIIRGFKSKKDTKFDAMLALNHQYEIKFEFQKSETDLACPLCGKPLKRNKAGMGCSGWKEGCKFMIFNPYCGKRLSDNQIEQLIKRGHTGEIKGFKKKSGNGTFSAILYLDDSDQYKVKMKFE
(1648) DNA topoisomerase 3 [Eubacterium limosum KIST612]
2
MSQNKTLVLAEKPSVGKDIARVLKCKNGQNGYLENDRYIVTWALGHLVSLADPEAYGEKYQNWNMESLPMLPEHMKLTVLKGSGKQYKIVSSLLGRSEVKDIVIATDAGREGELVARWILDKAHCHKPIRRLWISSVTDKAISEGFKNLKPGTEFNNLYRAAQCRAEGDWLVGLNITRALTVKYNAQLSAGRVQSATLNMIVEREEAIKNFKPKPYYNILAKTPQFTLTWQGQHGKNINSKETAEKILQKMKGKSAVIKDISKKPKKSTSPGLYDLTELQRDANRLFGMSPKETLNIMQRLYESHKILTYPRTDSKYLTQDIVPTLSERLKTISIGPYKAAVSEILKLGIHTNKSFVDDRKVSDHHAIIPTEQRVILANLSTDERKIYDLVIKRFLSVFLPPYEYLQTTVTADIAGEALTAKGREIITLGYKKVYENQSEEDDDEDNEDQQLPSLKKGNALAVSQISLKELETKPPARFTEATLLSAMENPQKVVKVDAKAAKTLGETGGIGTVATRADIIEKLYKMFVIEKKGNSLYPTSKGKQLIDLVPADLKSPLMTAKWERQLELISKGKSDPEAFIADIKTYTTELVNDVKNSNEKFVHDNKSGQKCPECGKNLLEVKGKYGMMLVCQDRTCGYRENVSKNTNVRCPECHVKLEIRGKGDGALYFCKRCGFREKVSSFNKKHFDGNRKNSKREAQNYMRKMKKENQEAVNNPFAEALAKLKESE
(552) DNA topoisomerase 1 [Butyrivibrio proteoclasticus B316]
1
MASKTTTTKKNSLLIVESPTKVKAIKKFLGNGYDVAASNGHVRDLPKSQMGVDVEHDFEPKYITIRGKGDVLADLRKKVKKADHVYLATDPDREGEAISWHLIAALKLDEADAKIQRVTFNEITKNAVKEAMKHPRDIDMNLVDAQQARRVLDRMVGYSISPLLWSKIKRGLSAGRVQSVALRIIADREEEIESFIPSEYWTLDVNLAAEGEKKPLVAHYYGTGNDKKEIKSKEELDKICASLKGAKYVVSDVKKGERNKKAPLPFTTSTLQQEASKALNFSTQKTMRVAQQLYEGIELGKQGTVGLITYLRTDSTRVSDEAVAAANAYISSNFGDKYLSEGTTAKKSDAKIQDAHEAIRPTYVENTPVVVKEFLSRDQFRLYQLIWRRFMASRMAPAKYETTSVKIDAGEHRFTVAASKTVFDGFLNVYTDEDDQIEKNVLMKNLDINTKLSFDSFDSAQHFTQPAPHYTEASLVHDLEALGIGRPSTYAPTISTILARHYITKENKAIFITELGQAVNKMMNDAFPQIVDVNFTSNMEALLDGIADGNVKWKTVVENFYPDLNEAVEAAEKEMEKIQVQDEVTDEICPNCGRNMVIKYGPHGKFLACPGFPECKNTMPYFEKIGVECPKCGKDLVLKRTRKGRIYYGCIGSPECDFMSWARPVKEKCPKCGKYMVAKSNKLACSDQECGFSCNKDELKKE
(294) DNA topoisomerase [Butyrivibrio proteoclasticus B316]
7
MAKKLIITEKPSVARDFARVLNVSGNNNGYIENDQYVISWCFGHLVEMVYPEEYDPKYKKWRLEDLPFLPAKYKYGVIKNSADQYKLINNLLHREDIDTVYWAGDSGKEGQTIEENIRNYGGVRDGMTELRVWIDSMTDEEVRRGIAQARPMSDYALLGESGIMRAIEDYSLGINFSRALSVKYGKLINDAAATKSYTAIAIGRVMTCVLGMVVRREREIRNFEKTPFFRIVGSFSDAKILAEWKAVSGSAYFESPLLYKENGFKKEDSAKALIDSFNGKEAVIDSIETGNSKKRAPLLYNLTELQADCTKRFKISPSQTLEIAQELYEKKLTTYPRTDARVLTTAVAKEIYKNVKGLSAVNEVSGFVDHVLKNGLYKGIEKSPYTDDSKVTDHYAIIPTGQTSAMGSLSPLAMNVYLLICRRFVSIFYPSAEYKTAKLQIAVGNEKFFAAAKVLVSPGYLEVAGIPKDKKAEDKKGDEEGNSSEDEEDVGISKEEFLKFVENAHKGDRISVNDYMIKEGATAPPKRYTSGDLVIAMENAGNLIEDEELRETIKKKGIGTAATRAAIIQKLIDNKYLAQSKSQIITPEKLGEMIYEVVYLSVPTLLNPEMTASWEKGLEGIYNGSVNGQDYRAKLEEYIRRETGKLIEKDLTTEIVGRINQFTGKESKGLASRKPIGIKCPVCGGEITTTSFGYGCSNYFNDQIKCTFSVGRIAGKDLDEETVKTLITEGKTGVIEGFVGKNKSSFSASLRLGKDENGKYAISFNFDDVPTVYVDNMNCPACGGRIIRTVNGYSCENRGKEEGGCYFYLGEVAGKKLTEEQVRTILSGEETEVIRGFKSKNNKPFNAKLVMKTSENGKKEITFDFEGVEPDYLADVVCPDCGGRIIKKTVGFGCENFKADDPQSCKFFIGKIAQKQISEANVIELLKEGRTGTIRGFKSKDKKPFDACLVMKKNENGVSEISFDFENVEAKTVKGVTCPLCGGDIVKTPFGYGCSNYKKDDPENSCKFNIGAIAGKNLKDAQIKELLLTGETTKISGFKSKSGKPFEAKLALDKGEDGKVKGIRFVFESEDEVMEDAKCPICGKQIIKGHLGYRCEDYKKGDEGCSFFIGKIAGVMIDKENFKKLVNEKITDKIAGFTSKKGTSFDAKLAFDEKFNVVFNFDN
(712) DNA topoisomerase 1 [Roseburia hominis A2-183]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVVASNGHVRDLPKSQMGIDVEHDYEPKYITIRGKGDILAKLRKEVKKADKVYLATDPDREGEAISWHLSQALKLDGKNVRRISFNEITQNAVKASLKQPRDIDMNLVNAQQTRRILDRIVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWTLDAKLKADGEKKPLTAKFHGDENGKLAITCREEADRIMDEIRGERFEVLEVKKGERVKKAPLPFTTSTLQQEASKTLNFPISKTMRIAQQLYEGVDVKGQGTVGLITYLRTDSVRISDEADADARAYIAQNYGEEFVATQTVTQKGGAKIQDAHEAIRPSDIARTPAVVKESLSRDQFRLYQLIWKRFAASRMASAVYETTNVKIGAGKYRFGVAASKVSFEGFMSVYTSEDDEKDTNNVLLKGIDEDTKLTLDTFDEKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTITTLLGRRYIVKEAKNLYVTELGEVVNQIMKESFPSIVDEHFTANMESLLDSIGEGAVNWKTVVRNFYPDLEAAVEVAEKELQKVKIEDEVTDVVCDQCGRNMVVKYGPHGKFLACPGFPECRNTKPYLEKIGVPCPKCGKDVVLRKTKKGRKYFGCENNPECDFMSWSRPVAEKCPKCGGYMVVKGNKIACADAGCGYTRDRKADEDTK
(610) DNA topoisomerase III [Roseburia hominis A2-183]
7
MAQHKLVIAEKPSVAQSLAAVIGATVRKDGYLEGNGWRVSWCVGHLAGLADADSYDPKYAKWRYDDLPILPEHWQMVVGKDKKKQFDILKKLMNAPDVTEVVNACDAGREGEMIFRSVYELAGCKKPMKRLWISSMEDSAIRKGFANLRPGADYDGLRDAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDTFKPIPFYTVALELPGLTVSGERMADKAAAEQLKEACQGVNVTIKKVECKEKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQSLYEKKLCTYPRTDSRYLTGDMADSLPVLVNLVANAMPFRKGIAITCDPQTVINDKKVTDHHAVIPTRNLKDADLSALPAGEKAVLELVALRLMCAVAQPHIYSETVVIAACAGGEFTTKGKTVKHPGWKALEDAYRAKMKDTEPKKEGVEKALPELTEGQTLSVSAAIVKEGKSSLPQHFTEDTLLSAMETAGKDDMPEDAERKGLGTPATRAGILEKLVSAGFLERKKNRKTVQLLPSHDAVSLITVLPEQLQSPLLTAEWEYRLGEIERGQLAPEEFLDGISTMLKDLVGTYQVIKGTEYLFTPPREVVGKCPRCGGEVAELQKGFFCQNDSCKFAIWKNNKWWAAKKKQPTKAVVSALLNDGCVRVTGLYSEKTGKTYDAAVVLEDDGQYANFKLEFDQRKGGSR
(1268) DNA topoisomerase [Roseburia hominis A2-183]
7
MQLVVTEKPSVAQAISHVIGAKERKDGYMEGNGFLVSWCVGHLVELAQPEMYSEAWKKWSYESLPMIPEQWQHEVKKETATQYKILKNLMHDTRVESVVCATDAGREGELIFRLVYEQAGCRKPMKRLWISSMEESAIRDGFENLKPGSDYDSLYQSALCRQQADWLVGLNGTRLFTVLYGGKVLKVGRVQTPTLAMLVDREVKIMNFEKEQYYMAHILMDGIDAMTERIDDKARAESIAAACESQSGVVRSVIKENKSVAPPKLYDLTTLQRDANRIFGFTAKQTLEYTQSLYEKKLVTYPRTDSQYLSDDMEETAKAVIGAVYQAILFEEQTGAEPDIKRVLNSKKVTDHHAIIPTIEITKTDLSAVPEGEMKILSLVANRLLCATGKKQLYETVKAEFSCGGYSFHVSGKTVLQNGWKEFEAALKRTYRVEKTDEDKEEKKLPELSEGMTFPVIQTKVTEHFTQPPKHFTEDSLLSAMERAGAEDMGDEVERKGLGTPATRADIIEKLVKDGFVKREKKQMLPTEDGMKLITVLPDMVKSPKLTADWENTLTLVEKGEYTMQEFMDGIEDMVRELVQTYHSISDDQKSLFGTMQEVLGKCPKCGSDVVKGKFGAYCKQKCGMNVGRAMGATFSDTQMKSLLEGKKTLVRGLKGKKGSYDAYLIPEGIEDYSYIKDGKEIKGSQYKFKMEFPPRKSK
(10) DNA topoisomerase [Roseburia hominis A2-183]
7
MAKSLIITEKPSVAQEFARILGVSGRNDGYIENDGYVITWCVGHLVEMVYPEEYDERYKKWRLEDLPFLPRDYKYNVIPSVSRQYDVVHKMLHREDIDTVYWAGDAGKEGQTIEENIRKFGGVREGMKELRVWIDSQTEEEILRGIREAKDMSEYDNLAKSGVMRTIEDYAMGINFSRAMSVKYGKLLNDAAGTSSYTAIAVGRVMTCVLGMVVIREREIRNFTETPFYRVVGTFHPEGEEECRITAEWKAIEGSKYFESPLLYKENGFKKEESAQTLIAELKGQEALIDSVETGTQKKRAPLLFNLAELQAECSKRFKISPDETLQVAQDLYEKKLTTYPRTDARVLSSAVAKEITKNISRLKNFAPVAPYVERIMKEGRCRNIANTQYTDDSKITDHYAIIPTGQLTELESLNSLERSVYEMIVRRFLSIFYPPAEYQTVKLVVAAGGEKLYTSAKQLKVPGYLEIAGIPKSAKERNAAKTDGEEQTQGGDAEAAQEEEENAGLLAYADKLQKGETLFSDGYVIREGKTSPPKRYTSGSMVLAMENAGQLIEEEELREQIKGSGIGTSATRAEIIKKLVRVGYLNLNKKTQVLTPERLGEMIFEVVSMTVPALLNPKMTASWEKGLDGITRGAVVMEDYRSKLEDFIRRETVAMIEQDLTGQIATRIHPLVGKGGKGLAAKRSLGIPCPVCGGTIETTPFGYGCSNYQKDGGGCRFSIGTIAGRDLNDEEVKELLTEGHTGVLSGFVSKSKKKFSASLILEKDDEGKVSVGFDFSKNQPEILEGVVCPVCGSAVEITPFGYSCVKHHEHPDECYFSVGKIAGKALGVDDLTELLTTGKTGLIRGFTARNKKKFNACLKLEQTEDGRKNIAFDFSQNDAAVVPDVVCPICGGAIVETSFGFGCANYRQDDPDSCRFAIGTMAGKDLNAAQVKELLNQGRTGTIRGFKSKSGKKFDACVALEHTEDGRIELRFDFEHVEAKKIKDVVCPICGGDIVATPFGFGCANYVKDDPNSCRFSVGKMAEKALTEANVKELLTNGRTGTIRGFKSKSGKKFDARVALAKDEKGKVTGLKFDFTDLEAPKVKDVKCPVCGGDIVKTMFGYGCANYSKENPDSCRFAIGKIAGVSLKEAQVKELLLRGKTDVIKGFVAKTGMKFDAPLKLTPEGQIAFDFPEKPKPVETTLACPKCGKMLKKSQWYYECECGFKVSHTVAKVALTEEVMRELLETGKTKDKVTGFVSKAGNTFDTCLKLEDDRIVFDFDNPGTKREGASDGKGGERMFYEELEENAQPQPLAAEDGAQYIEEDVPPFYDAMAEEYAAYEEEEAKQQAAASNFLDEFPG
(965) DNA topoisomerase 1 [Thermincola potens JR]
1
MSKVLVIVESPAKAKTIGKFLGSRYRVKASMGHIRDLPKSQVGVDVEHDFAPKYITIRGKGEILKDLKQAAQKSSKVLLAPDPDREGEAIAWHLMHYLDINEKDKCRIEFNEITKDAIVNAIKEPRTIDRHRVDAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEIKAFVPEEYWDITGVFTGTDKKWTIEAKLLQKGKEKIHIGSEAEAQAILDDLKDASFLLTKLRKKEKKRNPVAPFITSSLQQEAYRKLNFPARKTMQVAQQLYEGLDLGPEGTVGLVTYIRTDSTRVAETAQAEAREYIKGKFGTGYVPEKARQFTTKGKIQNAHEAIRPTSVFREPDQIKNFLSRDQYKLYKLIWERFVSSQMSPAVLDTTSIDIEAGDYTFRAHGSIIKFPGYMKIYTEGKDEDDNEEEKTLPENLEEGLRLIAKSLVPKQHFTQPPPRYTDATLIKALEEHGIGRPSTYAPIVETIQKRGYVVKEQKQFHPTELGMVVVELLKEHFTDIIDIQFTAAMEEKLDLIEEGDMDWVQVLKDFYLPFKDTLERAEKVIGQVELEDEVTEEICELCGRNMVVKMGRYGKFLACPGFPACRNTKPLLEETGVKCPHCDGRLVLRRSKKGRKFYGCSNYPDCDFVTWDLPTEKKCPKCESMLVQKKFKNKGAVYQCISENCNYKEKAETITI
(1039) DNA topoisomerase 1 [Desulfotomaculum carboxydivorans CO-1-SRB]
1
MGCTNLSKTLVIVESPAKAKSIGKYLGRNYTVKASMGHLRDLPKSQFGVDVESNFSPKYIAIRGKGEIIKELRAAVKKADRILLASDPDREGEAIAWHLSKLLDIDENSNCRIEFNEITKQAIQQAVKHPRPIDIDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLIVDREEEIKAFIPEEYWSLTAKFSKTAKSTFEAKLYKYQNKKITIPNQEAMDKILADLKGVSYVVASVTRKEKLRNPAPPFTTSSLQQEASRKLNFTARKTMAVAQQLYEGLELGKEGPVGLVTYIRTDSTRVSETAVEEAKKFILERFGPAYVPKESRQTVAKGKVQDAHEAIRPTSVERDPETIKEFLTNDQYKLYKLIWSRFLASQMAAAVMDTTSMDIEGGDYLFRATGSIVKFPGFMQVYIEENDDGTKEEEKLLPELAQGDKVEAKSLTPKQHFTQPPPRYTDATLVKVLEEKGIGRPSTYAPIVETIQKRGYVVRENKQFYPTELGIIVVDLLKNYFPDIINIEFTAEMEEKLDQIAEGDQDWVNVLKDFYGPFQQTLATAEEKIGKVQVADEVTDEICEQCGKNMVIKMGRFGKFLACPGFPDCRNTKPLLEPTGVACPRCEGELVLRRSKKGRKFYGCSRYPECDFVTWDVPTNEKCPHCGDLMVEKSSRGKEKILQCVNENCPSNAGVKETKAGQKTKQTTSNK
(320) DNA topoisomerase 1 [Thermaerobacter marianensis DSM 12885]
1
MPKTLIIVESPAKAKTIKKFVGRDYTVEASMGHVRDLPKSQLGVDVDDHFTPHYITIRGKGKLIERLRQQARQADRVLLATDPDREGEAISWHLCQLLEIPQDSPCRIVFHEITRDAVRRALKEPRPIEENLVDAQQARRVLDRLVGYKLSPLLWRKVRRGLSAGRVQSVAVRLIVDREEEIEAFTPQEYWTLEADLQRRAGGEVFTARYHGDAEGKKDLPNRDAVDRLLADLEGRSFTVLGVERKERRRNPAPPFTTSTLQQEASRKLGFSVRRTMRIAQELYEGIELRGEGAVGLVTYIRTDSTRIADQALDEAAAYIAERFGPEFSAPRKQAGRRQAQAQDAHEAIRPTSVAREPDAIKDDLTPDQYKLYRLIWERFVASQMAPAILDTVTVEIGAGPHRFRATGSTVKFPGFMQLYVEGRDEGTEGEGDEGEGMLPELAEGDALDVRALRPEQHFTQPPPRYTEAMLVRALEEKGIGRPSTYAPIIETIQERGYVVKEDRRFRPTELGRVVTALLKEHFPDIVDVEFTARMEADLDRIEEGERNWEDVVRDFYGPFSETLSRAERQIQRVTLPVEETDEICEKCGRRMVIKHGRYGRFLACPGFPECRNTKPLVEKTGARCPRCGGEMVQRRSRKGRVFYGCSNYPECDFTTWDRPTAETCPECGTFLVEKRSRQGVRLVCANPQCNYEREAAGETAGAGAGSGRR
(773) DNA topoisomerase 1 [Sulfobacillus acidophilus TPY]
1
MESPAKAKTISRFLGSRYQVKASMGHVRDLPKSQFGVDLERGFEPRYITIRGKGPLLKELKDAAKKTDRVYLATDPDREGEAISWHLAESLGIPLAEARRIEFHEITKDAVTEAIRHARPIDMHLVDAQQARRVLDRVVGYQLSPLLWRKVRPGLSAGRVQSAALRLLVDREDQIQAFQPEEYYTVTLTLDTQPVMTAQYAGPLGEKGRLSPVDAQTVVGRVKKGQTVHVESVKTRERRRFPALPFTTSTLQQEASRRLGFSVKRTMSIAQQLYEGLDVQGEGTVGLVTYIRTDSTRVADVAEAEARQFIESQYGTAYWKGLGAAKRPEKERPGVQGAHEAIRPTSVMRHPDRLKASLTRDQLRLYRLIWERFVASQMAPLVYDATTVELSVGEDRFRAHGAVVKFAGFTVLYQESAADDTKAANEDDAGQGPLPVVQEGQTLTATAVEAEQHFTEPPPRFTEASLVKTLEELGIGRPSTYAPIIDTLLQREYVQREQKRLIPTPLGRLVVELLQKYFPEIVDISFTANVENQLDRVESAELGWREVLTDFYRPFAEELAKAEQDLEKVAIPVEETDEVCDQCGRPMVVKYGRFGKFLACSGYPECTATKPFVEKTGAVCPKCGDQLVVRRTRKGRTFYGCHSYPACDFVTWLRPTEKTCPRCGSSMALRKKGRQETLTCLKEGCGYEEQAQ
(9) DNA topoisomerase 1 [Desulfotomaculum kuznetsovii DSM 6115]
1
MSKTLVIVESPAKAKSIGKLLGKKYTIKASMGHVRDLPKSQFGVDVEHGFTPKYITIRGKGEIIKELRTAVKKADRVLLASDPDREGEAIAWHLANVLEIDENAPCRIEFNEITKQAVQNAVKAPRPIDYNRVNAQQARRILDRLVGYKLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEINAFVPEEYWTLTAVFTRRGKDPFEAKLYKIGDKKAEIKNQAQIEEILKELKGVSYRVVKITRREKTRQPAPPFTTSSLQQEAYRKLNFTARKTMMVAQQLYEGLELGKEGPVGLVTYIRTDSTRVAVQAQMDARAYIQEKFGPGYVPEKPRQVAARGRAQDAHEAIRPTAVEREPEAIKQYLTPDQYKLYKLIWSRFVASQMSPAIIETTSIDITGGHYTFRAAGSVVKFPGFTRVYVESRDDETKEEEGVLPALSEGEALEVKSLTPKQHFTQPPPRYTDATLVKALEEKGIGRPSTYAPILETIIKRGYVVREKKQLVPTELGMVVVDLLKKHFPDIIDVEFTAQMEESLDRIEEGEMDWVRVIQDFYGPFQETLARAEEEIGQVTVSDEVSEEICEQCGRNMVVKMGRYGKFLACPGFPECRNTRPLLEPTGVPCPQCKGELVVRRSKKGRKFYGCSRYPDCDFVVWDEPSGEKCPRCGGILVIKKGRGEQEELECVNEQCRYRVDREKKAGSNGEAARDVAAGSKLVEEKPSFDSWHNDALLPLMRAKSGRTATRGTGGRS
(679) DNA topoisomerase [Desulfotomaculum kuznetsovii DSM 6115]
7
MRKLVIAEKPSVARDIASALGKFAQKDGYLENDRLVISWALGHLLELADAHEYDPAFVKWTLEPLPIIPEEFKLHPIRSGAKQLKILKQLLNSADVAEVINACDAGREGELIFRRIYEWCGCRKPVKRLWLSEATPSAIREAFKKLRDGRELDNLAAAARARAEADWIVGINATRAFSVKHKTLLSVGRVQTPTLALVVQREREIRDFKPETYWEVRATFQKSGGATYRGRWFRGGESRIKEKSRAEELVRAALAAGSGRVAQVEKRTKTEAPPLLFNLNDLQKEANRKYGMTAQKVLDAAQALYEKHKLITYPRTDSRHLTEALARDTLQKRLAALEKCPEYGELIRRIRPGMLPGKRYIDDAGVTDHHAIIPTDVTPDPSALNPAERQVYDLVVRRFLAMFYPPAVYDETAVVTEVGDETFISRGRVEIEPGWKAVYGPEEKEEKDGKDEDGESQPLPPLAEGETVGVEEAGAVERQTKPPKRYTEATLLAAMENAGRLLDDREMAETLKAAGGIGTPATRAAIIETLIKRGYIERRKKTLVPTPRGEALIDLVPEKLKSVELTAQWEDGLRRIEEGLDDARLWLVGLKNFTVEVVAMAKEQEANGAVHQKEVMGRCPLCGRDVLEYTKSYGCSGYRDGCNFAIWKETAGKKITAKQARELLQKGRTGVIKGFKSKAGKSFDAILTLGEDGKVNFEFADHAGQALGKCPLCGKDVIEGKKGYGCAGWKEGCKFVIWKEIAGKKIAANLAKELLQKGRTGVIKGFKSRAGKDFEAALVLGEGGKIEFEFKNRQEG
(398) DNA topoisomerase 1 [Syntrophobotulus glycolicus DSM 8271]
1
MPKTLVIVESPAKAKSISKFLSKNYQVKASMGHLRDLPKSQMGVNIEHDFEPKYIPIRGRGDLIKELKAAAKTADQVLLASDPDREGEAIAWHLMHLLGINQEKSSRVEFHEITKPTIQKAIKNPRKIDLHKVDAQQARRVLDRLVGYKLSPLLWKKIKKGLSAGRVQSVAVRLICDREEEIKVFESQEYWTLLAQFLCPGGNFSAKLIHKAGKRIEIKSRQEVDEIIVQLRRAVCVISDVKNREKKKQPSPPFTTSSLQQEAYRKLNFAPKRTMMLAQQLYEGIDLGKEGTVGLITYMRTDSVRISELAQDEAKEYILASFGSDFYPGRQNYTSKRRTQEAHEAIRPTSVLRTPDSAKEFLSRDQLRLYRLIWDRFLASQMSAAVYDTLTVDVAADKYTLRANASTVKFPGYLSVYEESTDETEEKQDGDDRCLKVNVTPGQKVELAEIKEKQHFTEPPPRYTEASLVKKMEEEGIGRPSTYAPTIDTVQTRGYVVKEERKLVPTELGEIVVSLLKEHFKDIVDLEFTANMEEKLDNIEEGQTQWKSVIRDFYIPFEETLNKAEAIIGKIKVEDQESDVLCEFCGRRMVIKMGRFGKFLACPGFPDCKNAKPLLEEVGVNCPQCGEKLVVRRSKKGRKFYGCSNYPECNFISWEKPAPVNCPDCNSLMTEKTIKQKVNYVCTNKDCRHTEEKVEEKKE
(1311) DNA topoisomerase 3 [Syntrophobotulus glycolicus DSM 8271]
2
MGKSLVIAEKPSVGREIAKMLSCHKKDQGYFTGPKYLVTWALGHLVTLADPEKYDQRYKTWKMDDLPMLPEQMELVVIKETSKQFSVIKNLMKMPDLDELIIATDAGREGELVARWIIKKAGWRKPIKRLWISSQTERAIKEGFAALKPAKEYDHLYASAECRAQADWLIGLNVTRALTCKFSAQLSAGRVQTPTLAMVVEREKQIKSFVPKEFWTIQAFTKGFSMTWHDKTNGQSRIFDQSKADQMIKKISGHDAEITEIKKESKKELPPLAYDLTELQRDANRKYGFSAKTTSSVMQQLYEYHKIVTYPRTDSRYITEDIVSTLPERLNSIAVGPYAQFAAKILKNKITTTKRFVDQSKVSDHHAIIPTEQPVHLQKLSNEEYKIYDLIVKRFLAVLSKPFEYEQTTVKADIRGELFEVKGKIVKQNGWKEVYQGTGNWEEEQEDEEREQTLPDLHKGERIPILEVKTKAGKTKPPARYTEATLLTAMEHPGKNIENEKLREAVKQTGGLGTPATRAEIIEKLFSSFYLERNGKEIFPTSKGLQLIELVPVDLKSAELTAKWEQQLSEISKGKVKSTEFLNGIRSYARQLVSTVSENNQVFRHDNLTRNKCPECGKFLLQVKGKKGELLICQDRECGYRKGLSVSSNARCPNCHKKMDLKGEGENRIFTCTCGYREKLASFTQRKSENPGKVNKKDVQKYLNKQEDNGMINDALAQALAKLKK
(116) DNA topoisomerase 3 [butyrate-producing bacterium SM4/1]
2
MKSLVIAEKPSVGKDIARVLGCRKSADGCLEGDKYIVTWAFGHLVELAAPEEYDKKYKDWNMADLPMMPEPFKLEVIGKTAKQFGVVKRQLFRNDVKDIVIATDAGREGELVARFILMKAGCRKPLKRLWISSVTDRAIKEGFSRLRDGREYNHLRDAAMCRAEADWLVGLNATRALTCKYNAQLSCGRVQTPTLAIIAKREEEIRNFRPKAYWGLTARTSKPALTLTWQDKKSGGMRSFDRDRMEGLQKSLRDQQVWITKVKKTPKKTMAPLLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDVADTIHDRLAACGTGPYRKLAGKLSKNVWTKKASFINDGKVTDHHAIIPTEQFVQLQNMTSEERKIYDLVVRRFLAVLYPAAEYDETVITAEIGGEIFTARGKVMRTPGWREVYESADESGLSGTGGYLDEEDGDEDGEGPQNERVKAQTLPDLREGDVIGPAGISLTEGKTKPPAPFNEATLLSAMENPVRYMESGDRAMAKTLGETGGLGTVATRADIIEKLFSGFMLEKKGKDICLTSKAKQLLRLVPEDLRKPELTAQWEMRLSKIAKGEMKRDAFMEDIRTYTKDIVEEIKGGEGTFRHDNLTNTKCPRCGKRMLSVKGKNSQMLVCQDRECGYRETISRTSNARCPKCHKKMELRGKGENQMFSCVCGYKEKLSNFKERRQREGAGVTKRDVARYLNQQKKEEKMVNNPFADALKKMQEQDV
(1040) DNA topoisomerase 1 [Clostridiales genomosp. BVAB3 str. UPII9-5]
1
MDKTLVIVESPAKAKTIGRYLGKDYEIAASVGHIRDLPSSTMGVDINNDFKPRYINMRGKEKIINDLKAKAAANAHTLIATDPDREGEAIAWHLANVLHIDPLSLCRITFNEITKNTVKTAVEQPRAIDLDLVNAQQARRILDRLVGYELSPLLWSKVKKGLSAGRVQSVATLMLVEREEAIRSFEPQEYWLLSVHLAEEKQPLADFTAQFYGRLDASGKCVKEELPDASAVENIKKQIQEPYKVLEIVKRNRQRNPAPPYTTSTLQQDAARKLGFSAKKTMLIAQQLYEGVDLPELGATALVTYIRTDSVRSSADAVAGMRKIIVSTFGPEFVPAEPNHFKNKNAAQDAHEAIRPSHLELPPEKIKVGLSTEQYKLYRLIWERFLASQMTPAKLAATTINIAAGDIIFRVTGETVIFPGFLKVNPEKVAEKEMNILPDLEKNETLRKLELLEEQKFTQPPARYNEASLIKAMEEAGIGRPSTYAPTLSTIMERQYAVKENKSLIPTELGFLVTNILREHFKKLINIKFTAEMENDLDEVESGKLNWVELIKNFYPVFHAAIVKAQKDISKIVIPVEATGEKCPECGADLVIKEGRFGKFIACSAFPNCKFTKNAVEKVDGHCPRCGSDLVSRRSRRGSIFYVCSQNADDKNCDFISWDLPVDNEKCPECGSYMVWHRLRGRLYKRCSNDSCVTRKSKRGKTDKNVAGEKQANDTAEPSAVETKRRKNTPKEKKKDND
(1074) DNA topoisomerase [Clostridium kluyveri DSM 555]
3
MKLILAEKPSLALNIVKSIGNMNRNDGYFENRDYLITFAYGHLLRLYDVDNYFKRGKTKWNLDELPFVPEDFKFKIREDKGVKKQYEVIKNLIRRNDVTEIVNCGDADREGEVIVNNIISRIFKEENINKPVKRLWLPEQTTQTIRQELRNLKDNRDYKNLYNEGLARTYLDWTYGINLTRYLSIKSQTFLPVGRVLIPIVKFIYDRDRAIENFKPETYFEIGAVIKKDNLEIKAKLKDRRFSADEREKAANLLNSLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKQFKMSLDDTLKHLQKLYECGFTTYPRTNTEYLAENEKGKIKSIIEVMKEKFNVDIDFKDKKKIFDNNKVESHSAITPTTKIPEIEKLSEDEKKVYTAIRNRFISNFLNEETIIEETYVIIRIVDEVIELKGNVIKQTGFLKYENIKKENELPDFVEDEKLDTKLSVDEKQTQKPNRVTESELNNFLKNPFKKKEIQDLENTNDDEEYKMILEGCEIGTVATRAVIIKNAQKYEYIKEVKGHFECENKGIRLIDVLKRLNIDLDKGKTVEFGKQLKGVYKNDIEINTIIYNVKSELNNIIRKGDEIKIDRIESKKYESMGVCPICGKGNIMANKFGYGCSRWREGCKFFIGKQIAGKNISESMAKKLIKNKKTNVIKGFKSKNGKSFDAVLTIKDENVAFDFSSESKGLGTCPVCGKGNVIANKSGYGCDKWKEGCKFFIGSKIASKSITESMVKKLLKDKKTNLIKGFKSKNGEVFDAFLIIKDSKIVFDFKE
(878) DNA topoisomerase 3 [Clostridium kluyveri DSM 555]
2
MSKILVLAEKPSVGRDLAKVLHCNKKNLGYIEGDKYVVTWALGHLVTLADPEDYDERYKSWVLEDLPMLPDKLKLVVIKQSGKQFNIVKSQMNRKDIGEIIIATDSGREGELVARWIIEKARVKKTVKRLWISSQTDKAIKEGFANLKNSSKYDNLYKAARCRAEADWVVGLNITRALTCKYNAQLTAGRVQSATLAMIVNREEEIKNFKAKDYFVINAKTKEFTLMWRDKNNNSNIYEENRVNKILAITKGKAANIIDVRESYKKQYAPALYDLTELQRDANRIFGYSAKHTLSIMQRLYENYKILTYPRTDSRYISTDIVDTLKERLKAISVGSYKIYASELLKTRINAHKGFVDNSKVSDHHAIIPTEEVLTLSLLSSEEKNIYDLVVKRFLAVMLPPFEYVQTSIITDINGENFIARGKVVKSKGWKKVYDIGNQVIEDDENENQILPELKKGDSIDIISIESRRLKTKPPARFNEGTLLSAMEKPQKYISIDKLYAKTLGETGGIGTVATRADIIEKLFNMFYVEKNGKDIIPTSKGKQLIELVPEDLKSPLLTAQWEMDLELISKGKKDPEVFIRKMREYAGTLVEDVKESSNKFKHDNITGKKCPVCGKYMLEVKGKQGRMLVCQDRECGHRENLARLTNARCPECHKKLELKGEGEKRIYVCSHCSFREKFSSFNKRFKENEGKLNKKEVSKYMKKMNGENKANINSSLAEALANIKFK
(194) DNA topoisomerase III [Oscillibacter valericigenes Sjm18-20]
7
MKLVIAEKPSVAQSIAAVLGAKQRGGGYLEGSGWLVSWCFGHLAELASAESYNPEYAKWKYDDLPIVPETWRFKVSRDKWQQFDILKKLMHSEDVSEVVNACDAGREGELIFRTAYCLAGCSKPMKRLWISSMEDSAIRDGFAHLRPGSDYDGLHQSALCRSKADWLVGINATRLFSVLYHRTLNVGRVMSPTLALIVQREAEIDAFRAEPFYTVELDVGFPAVSEKFREESQAKAVAAACQGQPAAVKSVERKEKSEKAPALYDLTTLQRNANRLLGYTAQQTLDYLQSLYEKKLCTYPRTDARFLTDDMEGSVPALVSVAATLYEAAAPGKIGAAQICDSKNVSDHHALVPTVSAGKAALSALPAGERKILRLVSRQLLCAVSEACRYAETVAAVECGGSVFTAKGRTVLAPGWKNYIQQEQPEKPLPDLTDGQALTVSGISTKEGKMTPPKHYTEDTLLSAMEVAGAKETPDDAERKGLGTPATRAAILEKLVSTGFVERKKAKKTVSLMPSHTGVSLITVLPEQLQSPLLTAEWEQKLKQVERGELTADAFLDGITAMLRELVKTYKAIKGAEVLFPSGREVVGKCPRCGGDVTESKKGFFCESADCRFGLWRDNKFLTAKRAVLDKKAVTALLKTGRVAMTGLYSEKTGKTYDATLVLEDDGQRANFKLEFNHG
(689) DNA topoisomerase 1 [Oscillibacter valericigenes Sjm18-20]
1
MAKQSLVIVESPAKAKTIEKYLGKEFRVKASMGHLRDLPKSTLGVDVEHDFDPVYQPIKGKEDIISDLKKSAKAADTVYLATDPDREGEAISWHLKQLLNLPDSKTHRVTFNEITKKVVQESIQEPRDIDQNLVDAQQARRILDRIVGYQLSPLLWKKIRRGLSAGRVQSVATRMVDDREREIEAFKPEEYWTLDAVFRGDDAKKTEFTAHYHGRDGKKVELKSAEEVEAVVEETRNQAFAVSAVKRTDKQRSPSPPFTTSTLQQDASRKLSMTPRRTMAIAQQLYEGVDIAGEGTVGLITYMRTDSLRISEEALSAAKSFILGRYGKDYYPARTRHYKAKANAQDAHEAIRPSNVALTPEQVKGDLTGEQYRLYKLIWSRFLASQMENAVYDSVSVDIAAGEHMFRATASGLKFAGYTAVYEEGKDEEKEEKESPLPALREGEPLALKEFYRDQHFTQPPAHYTDATLIRAMEEQGIGRPSTYAPTVSTIIDREYVIKEGKYLKITNLGRVVTELMKQRFSDIADLQFTAHMEQKLDSVEEGVTPWKNVLRDFYGDFEKNLKDAETALEGTRIKVPDEVSEEICPECGRNLVVKSGRFGRFLACPGYPDCSFTMPLVVVMPGRCPKCGGRLMKRTGVSKKTGKQYNYYCCEHRTARDEAAKCDFMTWDVPVKDDCPVCGQTMFKRSGRGYKRPYCVNPNCSNFLPEDQRGYPKKKTDEGGESAGSAEAAEESATDVTAAKKATAKKPAAKAKSKRTAKEPAAKKSAAGSGADKKTGVTKTAARKPAAKKTAAKKTVAKKSAAEKEN
(1776) DNA topoisomerase 1 [Caldicellulosiruptor bescii DSM 6725]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINKLKKYAQEAEKVYLATDPDREGEAISWHLATILGLDTNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRILDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDVQEFKAKFYGDKKGKIELKNQDHVQKIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRVSEEAQQAARSLIVQKFGKEYLPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSVYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEALKPIKLESKQHFTQPPSRYTEATLIKALEENGIGRPSTYAPTIQTILERGYVAKEDRFLKPTELGRIVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVKKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPVKNCPKCGSLMFEKGKKGNKKLVCSNENCAYQEKTGEKGE
(1030) Reverse gyrase [Caldicellulosiruptor bescii DSM 6725]
6
MATGAKYYHSCINCSGINTDTRNEKGLPCEKCLKDDHLTENVFELLKGRGLLKDYQIYWNFHQNYKMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTVSLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEEFEKRFISCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAVLKSSKNIDTLLQMIGFSEDEIEKATERLRSKNRENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLDNSIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFSIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEILQTEKLRQLVSKYISKEDYSKIVNKIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKVSRKIQNDDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALRNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLDVPRIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGNEGAHEAIRPVKPISPEELKELAYEKYTQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFKINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSLTDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLLELYNDISVLLNN
(1340) DNA topoisomerase 1 [Caldicellulosiruptor kristjanssonii I77R1B]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEILKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGNLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(946) Reverse gyrase [Caldicellulosiruptor kristjanssonii I77R1B]
6
MATGAKYYHSCINCGGINTDIRNENGLPCEQCLSQEQINDIYESLKKMGTLKDYRLYWNFQQNFDMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANAVKILLFNSSMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFLIDMDKAPRFVLERVFVEYLDNHPKLKGYFKSVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWVEENGVDFKNLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLDFLPMQIYPLFENKDYGITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLQELYNDISALVND
(1306) DNA topoisomerase 1 [Caldicellulosiruptor obsidiansis OB47]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAEAAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATKLVVEKEEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQIQEIEEKIKNKEFKVVKLKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARKLIAQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMNPESIKDSLTPEQYKLYKLIYDRFLASQMESSIYDVLSAELEVEGYVFRLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEISEGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKIEWTEVVRKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKKVIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPKCGSLMFEKGRKGNKKLVCSNENCLYEEKMGEKGE
(1675) Reverse gyrase [Caldicellulosiruptor obsidiansis OB47]
6
MATGAKYYHSCINCGGINTDTRNENGLPCEQCLSQKQINDIYKSLKKMGTLKDYQLYWNFQQNLNAFKMFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANTVKILLFNSLMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRTKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLAENGIKIGTTWSNFDEEFELFKEEKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPRFRFSVDMDKAPRFVLERVFVEYLEDHPKLKEYFKNVEILQTEKLRQLVLKYISAESYNKIVQEIFSHLKITDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKESRKIQNNDFYQIDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIEDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNINLVKSQIVRRIEDRWVGFELSSKLQENFQSYNLSAGRVQSTILGWIVEREKEYAKSERTFTMLKLENGYNLEIEGEEECKRVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKEFFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIRVYQLIFNRFMSSQMKNPKVLFQKVCFKIADKEIVKDIPVKIEEEGWLHFLSMQIYPLFENKDYSVTDRRSYKKHTIQLYTQSSLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILQELYNDISELLNK
(714) DNA topoisomerase 3 [Alkaliphilus oremlandii OhILAs]
2
MYHHRIERIVNMNKKLVLAEKPSVGRDLARVLNCNKKGNGYLEGQEYIVTWALGHLVTLADPENYSDRYKSWKIEDLPILPSDLKLVVIKKTGKQFQTIKEQMHRKDVNEIIIATDAGREGELVARWIIEKAKVQKPIQRLWISSVTDNAIKDGFKKLKNGKDYEKLYQSAVARAEVDWIVGINATRALTCKYNAQLSCGRVQTPTLAIIAQREAEIQNFKSRTFYGMEAMSPHLKLTWQDRKTKDIRSFEKEKITSILNAIKNKDGYVMDVEKKYKKSYAPKLYDLTELQRDANRIFGYSAKETLGIMQQLYENYKILTYPRTDSRYITSDIVPTLKDRIKACGVGPYKLAANKVLQGSIKGNSSFVDDGKVSDHHAIIPTEQFVQLSSLSDKERKVYDLVVKRFLAVLYPPFEYEETFIRAKIGEEVFIAKGKNVIHQGWKEVYGNMDEDESGNEDISEQLLPRVNKGDVLKISSITQTTGQTKPPAPFNEGTLLSAMENPVKYMKDAHKDLIKTIGETGGLGTVATRADIIEKLFSTFLIEKRGNDIWITSKGKQLLELVPEDLKSPALTADWEQKLGAISKGDLHRDHFVKEMKAYTKTVVDEIKNSDETFKHDNLTRNKCPECGKYMLEVKGKRGKMLVCQSRECGYRKGVTQNTNARCPNCHKKLELRGEGEGQIFVCSCGHREKLATFKERKKQEGSKVSKKEVVKYMNQQKKENDGFANTALADALSKLKF
(1871) DNA topoisomerase [Alkaliphilus oremlandii OhILAs]
7
MKRLVIAEKPSVAKDIAKVLNCKEKREGYIEGSDYIITWAIGHLVILCDPEEYDIRYKKWDFNTLPIIPDKIKLKPNPKTYKQYQIVKALMLSSQIDEIICATDAGREGELIFRYIYELAKCRKPFQRLWISSLTDEGIRTGFEHLKDGKAYDALYYSAKCRSESDWLVGINGSRAYSIQYGSLLPIGRVQTPTLKIIVDRDLEIDDFVPKDYWEVKADFGNYSGIWIDLEKNESKIDSIQKAEDIKNKVLLKEGLVTDFQKKKVVKKPPFLYDLTELQRDSNKKFGYTAQRTLDIAQSLYEKRKAITYPRTDSRFLTKDIIPKLKSLINKIGLEGYKEFTSILEKLEKLPVNPRIINDRKVTDHHAIIPTEKKIDLNKFSEEEKNLYDLIARRFLAVFYPDYEYFSIVMITHVAGEDFKSNEQQTIHLGWKLLYSDKEVETKESTLIHIKKGSSSTLKSAEIEQKQTKPPARYNEALLLDSMENAGKFIEDEELKEQLKSSGIGTPATRASIIERIISVGYVERKGKNLISTEKGRKLIQITSQELSSPELTGKWEKALDKIAKGNMNPQRFMEGIGRFTKFIIEDVQKNTKNVVFEGYSKNRGKKSSGTSSYNSPIGICPACKVGKVLEGPKNFYCSEYKQGCKFGIFKEDILMKKFKKKMTKTMVSKLITNQVVTVKGMVSPKTNGKFDGNICLKQSSNGYWGWEFTNGGVNN
(857) DNA topoisomerase 1 [Alkaliphilus oremlandii OhILAs]
1
MTKSLVIVESPAKAKTIEKFLGKNYVVKASVGHIIDLPKSKLGVDIDNNFEPQYITIRGKGPVLKEIKTLAKKSKNVYLATDPDREGEAISWHLARALGIEASDDCRIEFNEITKNAIKSAIKKPRPINQDLVDAQQARRVLDRLVGYQISPLLWKNVRKGLSAGRVQSVATKLIIDREEEIKNFKPEEYWTLSLKIKTKNNENFEIKFQNDNLGNKEIHTEAEVDRILNHIQNHEAIVTSVKKGEKKRNPNLPFTTSTLQQEAANKLGFSTKKTMSLAQQLYEGIDIGKSGTVGLISYIRTDSTRISQESSESCKNYIHENIGESYYHSETKERKENKGKKNIQDAHEGIRPTDVYRHPDLIKGFLSKDQYTLYKLIWQRFVASQMAPAVYDTLNVEFDINKVIFKATGSILRFEGFLKVYSYANVSENINIPDLAEGEVVTVLEQMPKQHFTQPPGRYSEATLVKTMEDLGIGRPSTYSPTISTILSRGYVEKEGKSLTATELGYIINEILEDYFSKIIDTNFTAKLEQSLDYIEEGTQDWKKLISEFYEDFKVMLLNAEEHMEEINLVEESDEKCSKCDSVMLIKHGRYGKFLACSNYPECEETKPFLYKIGVSCPKCESGDVIEKRSKKGRLFYGCSTFPDCRFVSWNRPTGKKCPTCGDILVYKKTKKSEKNICINKECGFEEEIEN
(969) DNA topoisomerase [Coprothermobacter proteolyticus DSM 5265]
7
MSILIVTEKPSVARQIAAALGKPKKEGNHLVVGEYVIAHAMGHLLQFAYPEHYGERYKKWRLEDLPIMPKEDEWQLVPISKTAVKQLEEIKTLWAKADMVISATDAGREGELIFRLIQQYVGIEKPIKRLWLQSLTKETIREQIKQLLDLSELDNLYASALARAKADWLVGINASRAFTVVSKKEVFSIGRVQTPTLAILVDREKEIQSFVPRIYYKVKVRFEVEGKSFWAESVKEYDQEEAEKLAEELIGKTLIVTEQTEEQAKINPPLLPDLGDLQKFTSRSFKWSAQKTLKILQKLYENALITYPRTDSRYLPTDMKKQVIGTANQLEPLFAKGNWEYVKKLNNRGRIFNNARVTDHFAIIPTGKIKELKGDDEKMFNYVVDRFLAAFYPPALETHQKTVFSYGNHLFEYAAVRVDDPSWYTILGGKESQELLPKIAEVMVLETSAEKRQTRPAPRFTDGMLIAAMETAGKLVESEELAEILKEKGIGTPATRAEIIERLIEMGYVQRNGPQLIPTSKGIMLIDALREVKLQSLTEPELTGEWERRLGLIEKGKETPESFMWSIEEYVKDVVQTLSKEESSKTLKSKQNMPIAKCPFCDGYILEGQKSYYCSNWKEGCKFRVWKNMNGGVITADDVRRLVAEGRTRLKRFRSKAGKAYRAFVVLKDGEVVIEFPTRKKKDGE
(136) DNA topoisomerase 1 [Thermoanaerobacter brockii subsp. finnii Ako-1]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKGYANPEANYVSKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVEEFYKDFYKTLKIAEEQMEEIEVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPDCDFILWDKPVEEKCPVCGSMLIEKNTKNVHILKCSNPGCDYQKEVK
(665) DNA topoisomerase 1 [Thermoanaerobacter wiegelii Rt8.B1]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYSNPEANYASKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFLASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQERTKLFLEELKPMQHFTQPPPRYTEASLIKELEERGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVQEFYKDFYKTLKIAEEQMEEIDVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRNYYACENAPDCDFILWDKPVNEKCPVCGSLLVEKNTKNGHILKCSNPGCDYQKEVK
(1161) DNA topoisomerase 1 [Thermoanaerobacter italicus Ab9]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFTPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNFTKFEAKFYGTKEDKVELKTKEDVDKVLAALSEEYTVDKIKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYANPRANYASKKANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDIQEEEEKTVPVLQEGTKLLLEELKPIQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDNKNLKPTELGFIVTDALKEFFTKIVDVKFTAEMEEQLDKIEEGQAKWYEVVQEFYNDFYKTLKIAEEQMEEIDIKEEVEVTDIKCELCGRPMVVKKGRYGKFLACSGFPECKNTKPLYEKIGVKCPKCGGEVVRKKSKKGRMYYACENAPNCDFILWDKPVEEKCPVCGSMLIEKNTKNIHILKCSNPECDYHKEVK
(1433) DNA topoisomerase 1 [Finegoldia magna ATCC 29328]
1
MANKKLVVVESPTKAKTIQKMLGSGYKVVATIGHLRDLPKSKLGIDIENDFEPRYINVRGKANVINALKKDYKNSQKIFLATDPDREGEAISWHLCYLLGINPKEENRVKFQEITKDSVKEAIKKPEAIDLKLVDAQQARRVLDRIVGYSISPLLWKKVKSGLSAGRVQSVALRLICEREKEIREFEPEEYWSIHANLSKDKLDFDSELYYSKSDKSNKINIKNKDEADKILNDLSDKFVVDSIKQQKKARKPYAPFTTSTLQQEAYKKLYFQTSKTMRIAQQLYEGISLGSEGSVGLITYMRTDSTRISQVCVNDCLDIINELYGKQYATRGYDYSKKKKGSQDAHEGIRPSSVKRRPNEIKKYLTEDQYKLYKLIWERTVASQMKDARYLSTSIDFDNNGYTFRSNGNVVIFDGFTRVYSLNTKDSELPELKDREAISSNEIEPKQHFTKPKPRYTEASLVKTLEEDGIGRPSTYASIISSILSRNYVELKEKKFYTTEIGEKVCEFVVKYFDSIINEKFTAEMENELDNIAENDVEWKKVIRDFYNGFNEDLVNAKNAQDKFKVKDEPIGRKCPECGNDLVIKHGRNGKFIGCSAFPECKYTETIVKDTKVKCPKCGHRIIEKVSKRGKVFYGCENYPNCDFALWDKPTGEKCPECGSLLVHRKNRRGESVLCSNEKCNYKKLEK
(1145) DNA topoisomerase [Finegoldia magna ATCC 29328]
7
MKLVIAEKPSVAVTIAKVIGARTRKNGYYEGNGYIVSWCVGHLIQMASPERHDEKWKKWTIENLPIIPEEYIYEVSKSTKKQYGVLKKLLNDKNIDTVINACDAGREGELIFRLVYNQAKCKKKIQRLWISSMENKAIEDGFRNLKDGEKFEDLYGSASARAIADWLVGMNLSRLYSCIYKETYSVGRVQTPTLYLIAKRDSEINLFKKQKYYTVDLSYKGLKLVSDRIDKIEVAEQLLNLIEDEIVITEVEDKEISTKPDKPYDLTTLQREANKYFGYSANDTLNMAQGLYEKKLITYPRTDSRYLTDDMVTTMKELLEGLEEGFKINESNFKSIFNSSKVTDHYAIIPTISGIGKVKDLSDKESKVYNLIKDKLLASCSDNLKESSRKIRYEYDKFNFNASGKTIIDEGYTKYLKAYGKEKQENELPDVKTGDKIKLTSKNISEKFTKAPSHYNEDTLLKAMENAGIESLDKDIEVERKGLGTPATRAGIIENLIHKDLIRRDKKNLLVTEKGNRLVSIVEDKFKSAKTTSEWEMKLAKISSGEVDKEDFLREIEDSIRELVDRYKNNLNE
(765) DNA topoisomerase 1 [Pelotomaculum thermopropionicum SI]
1
MSKTLVIVESPAKAKTISKFLGKKFTVKASMGHVRDLPKSQFGVDVKNGFKPKYITIRGKGDIIKDLRAAVKKADQVLIASDPDREGEAIAWHLQNLLEIDENESCRIEFNEITKQAIQKALQHPRPIDRNRVNAQQARRILDRLVGYNLSPLLWRKIKKGLSAGRVQSVAVRLICDREEEIQSFVPEEYWTLVASFVKTGEAPFEGRLIKFRDEKIDIPSKEKMQEVLENLKGARYTVEKVTRKEKSRKPPLPFITSTLQQEAYRKLNFTARKTMMVAQQLYEGLDLGREGTSGLITYIRTDSTRVSASAREEAQKYIVERFGARYAGRETPPVGPAGRKGKIQDAHEAIRPTSVQREPEQVKEYLTGDQYKLYKLIWSRFLASQMKPAVFDTTNIDIKAGEYLFRANGSVMKFPGFMKVYTESRDDEEKEEEKLLPELKEGEEIEARSLTPRQHFTQPPPRYTDASLVRALEEKGIGRPSTYAPIVETILKRGYVVRENKQFFPTELGMIVVDLLKKHFKEIIDIDFTAGMEESLDSIEEGELDWIKVLESFYGPFKNTLEKAENEIGHVQVAEEVTEEKCDRCGRSMVVKVGRYGKFLACPGFPECRSTKPLLEPVGAKCPRCEGELVVRRTKKGRKFLGCSNFPECEFVTWDQPSGTKCPECGGLMVEKKNAGKKGFLQCVSEDCGYKKTAGEKKAGKKNADTESMSAET
(1134) DNA topoisomerase 1 [Ruminococcus champanellensis 18P13 = JCM 17042]
1
MSNLVIVESPAKAKTIQKYLGGDYDVIASMGHVRDLPKSKFGVDVEHDFAPQYMDMKGKEDVIKDLKKHAKKADKIYLATDPDREGEAISWHLAQMLNLNMEDNNRVAFNEITQAGVRNGMSHPHKIDVDLVNAQQARRILDRIVGYQLSPFLWKKVKRGLSAGRVQSVAVRLVVDRENEIRAFKTQEYWSIDAKLTAPSSRKVFAAKLATIDGQKAELATKEQTDGILQTLEQAQFTVAGVKKRVTNKQPAPPFITSTLQQDASRRLGFQAKRTMKAAQELYEGVEIEGMGAVGLITYMRTDSLRISDEAKAAAAAYIEQTYGKQYLPPTPRVFKSKKNAQDAHEAIRPSMPDLTPERVKNSLTTDQFKLYKLIWERFIASQMANAQLNTVSADITAGNCGFKASGYSVKFEGFTVLYEESKDADAEDNKVLPPLEQGDLLKVKSLDGNQHFTQPPARYSEATLIKALEENGIGRPSTYAPTITTILSRLYVERDGKQLRPTALGEVITELMKEHFKHIVDAKFTAKMETDLDRVEHGDCDWVSMLHGFYDDFEKTLSKAEVAMEGKRVKVPDEETDVVCELCGKKMVIKIGRFGKFLACPGFPECRNTKKIVQETKGTCPLCGKKIVLKKSKKGRSFYGCDNYPNCNFMTWSTPVEDTCPKCGCTLFKKGGRSGKLVCEKPGCGFERSLKE
(265) DNA topoisomerase [Ruminococcus champanellensis 18P13 = JCM 17042]
7
MSILIVGEKPSVSRAISAVVGASSAHKGYTEGNGYIVSWCVGHLVGLKFPNDYGNGWNQKWSFSQLPMIPDNWLFQIMDSTKAQYNLLKNLMNKDEVTEIICATDADREGECIFRYVYNMARCRKPVKRLWVSSLEESAIRKALSIMKTMSAYDNLFNAGYARARADWLVGMNGSRLFSVRYGGKLNIGRVQTPTLAMIVQRDAEVNGFIKQKYYTSDLNCGGFILSSARIDDENAADTLVSACDGSTVTISSVKREVKTDKAPKLYDLTTLQREANKGFGYTAQQTLDYTQSLYEGKLVTYPRTDSQYLSDDMAQTALDVAKLCDTYFGFGIFHTPDIAKVINNSKVSGHHAIIPTSGISTADLSSLPTGEKNILTLIATKLICATAPAHKYEAVKLTGICNGTEFTATGRTILDMGWKAYAKQTDKKNDEKSLPAVRSVLPFQRTMCQL
(1390) DNA topoisomerase 1 [Ethanoligenens harbinense YUAN-3]
1
MSNLVIVESPAKAHTIKKYLGRGYTVVASMGHVRDLPKSRMGVDIENSFTPKYIPIRGKAPLIKSLKKEARNSTKIFLATDPDREGEAISWHLANLLGLDEKTALRVTFNEITKTAVKDGIKNPRSIDLDLVNAYQARRILDRIVGYQLSPFLWKKIRPGLSAGRVQSVAVRLIVDREDEIRAFVPEEYWTIDASELLAPGSKKPFPAHFHGGLDGKKVEIKSKEEADAILRALGATETPEGIQVSGEVPFVVRTVKKSERKKSPAPPFTTSTLQQEASRRLGFQARRTMRAAQELYEGVDVKGYGAIGLITYMRTDSLRIAAEAQQAALAYVGETFGREYLPEKPRFYKSRANAQDAHEAIRPTMPELSPDQVKESLTADQYKLYKLIWERFIASQMANKVLDTVGVDITAGDCLFKASGNTVKFKGFSIVYEMTTDENKESGKPLPVLNEGDELQVQKLDGNQHFTQPPPRYTEASLIKTLEENGIGRPSTYATTITTILARLYVERDGKQLVPTPLGEVTTKLMREHFADIVDVEFTAKMENDLDKVETGEENWVQMLTDFYGGFDHTLKKAEEELGDVHMKVPDEETDIVCELCGRKMVIKNGRYGKFLACPGYPECKNTKPIVQETGAFCPLCGGRVLAKKSKSGKKYFGCEHNPTCGFMTWDTPLEEKCPQCGGSLFKKRGGQVYCAKEGCGYTREEKK
(364) DNA topoisomerase III [Ethanoligenens harbinense YUAN-3]
7
MRFVISEKPSVAQSIAAVIGAKQRGDGFLEGNGYLVSWCLGHLAELASADAYDEKYAKWRREDLPILPENWRFTVSGDKQKQFAILRTLMRRDDVDEVINACDAGREGELIFRTVYDMAGCSKPMKRLWISSMEDEAIRQGFADLKPGRDYDGLHQSALCRSKADWLVGINATRLFSALYHRTLNVGRVMSPTLALLVQREAEISAFQPEPFYTVSLDCGTFTAIGDKLKTKSEAEAVAAACKGKTATVRAVERKEKSEKPPALYDLTTLQRDANRLLGYTAQQTLDYLQSLYEKKLCTYPRTDSRFLTNDMKASVPAFASVAAAICGTDVPESLNAGQVCDSAKVSDHHAVVPTSGAGKADVSALPAGEREILRLVSRQLLCAVGSPHQYAETAVTLDCTGYGFAAKGKTVLVPGWKSCFQEQADKPLPELAEGQDIAVASVSVKEGKTSPPKHYTEDTLLSAMETAGAKDMPDDAERKGLGTPATRAAILEKLVTTGFVERKKAKKTVNLIPSQVGVSLVTVLPEQLQSPLLTAEWENRLKQVEHGKLEPDAFMNGISSMLRELIKTYTPVKGAEVLFPSGREAVGKCPRCGGSVTESKKGFFCENDGCRFGLWKDNRFFAAKKKVLTKAVAAAFLKDGRVRLTGCYSEKTGKTYDATVILEDTGGRVNFKLEFDSGTKKRGGS
(1262) DNA topoisomerase 1 [Candidatus Desulforudis audaxviator MP104C]
1
MEKTLVIVESPAKARTLGKFLGKKYEIRASMGHVRDLPRSQFGVDVDDGFKPKYITIRGKGDAIKELRAARKKSNQVLLASDPDREGEAIAWHLQELLQIDPEEPCRVEFNEITREAVTAAIKNPRKIDPNRVDAQQARRILDRLVGYNLSPLLWRKVRKGLSAGRVQSVAVHLICAREREIEAFVSEEYWTLTALLANRERERFKARLLKKAGEKLTVPNEEAMKGILDDLKEEVYRVADVIRKEKKKNPSPPFTTSTLQQEAYRRLNFTTRKTMMVAQQLYEGLDLGKEGPVGLVTYIRTDSTRISPGAQDEAREYIAEHYGKEYVPKQKRVYTGKARAQDAHEAIRPTSVLRTPEALRKYLNPDQLRLYELIWSRFLASQMVSAVLDTVRAEIVAGEYLFRATGSTVKFPGFTRVYTELRDEAKNGEEEEEGALPALEKGEQLKLVRTTPARHFTQPPARYTEATLVRTLEELGIGRPSTYAPVVETIQRRGYVVRRGKTLHPTQLGLVVIDLLKEHFPDVINYEFTAELEEKLDRIEEGSMQWEKVLEEFYRPFRREVAEAEAKIDRVRLDEVTDEECRKCGRKMVIKMGRYGKFLACPGFPECRHTRPIFEETGHRCPKCGGRVVVRRTKKSKVFYGCAGYPGCDFVTWDQPTDQKCPDCQSFLVARGTRGHPLQRVSGSAGQSRTFACANPECGYKERKAGRGKA
(190) DNA topoisomerase 3 [Desulfotomaculum ruminis DSM 2154]
2
MNKTLVLAEKPSVARDLARVLNCGKKGNGYFEGDQYIVTWALGHLVTLADPEAYDQKYHSWRLEDLPILPSYLKLVVIKQSSRQFYTVTAQMNRKDVAEIVIATDAGREGELVARWIIEKAQVKKAIKRLWISSVTDKAIRDGFRSLKKGQAYEHLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAIIAKREEEIKNFKPKNFYGITAVSNGLKLTWQDSRSKDTKTFDADYCDKILLAIKNKPAEIIEVEKAHKKSFPPQLYDLTELQRDANRLFGYSAKETLSHMQRLYEHHKVLTYPRTDSRYLSTDMVETLKDRVEACRDNPYTKMAFKILKNPIQISKSFVDNSKVSDHHAIIPTEQPLCLSALNDKERKIYDLVVRRFLAVLYPPFEYEQTTLKAKIGQELFIAKGKRVLAQGWKEVYDNQFEDEDQPEGLAEQRLPGINKGDRLKISSISQTKGETKPPEPFNEGSLLSAMENPTKYMANQDKELIKTIGKTGGLGTVATRADIIEKLFNSFLIEKKGKHIFITSKGRQLLELVPGDLKAPDLTAEWEQKLEAIAKGVLNKNHFIDEMKQYAKLLVHEVKNSENKFRHDNLTGNKCPQCGKRMLEVNGKKGKMLVCQDRECGYRKGLSKITNARCPNCHKRMELHGEGEGQIFVCPCGYREKLTAFNERRGKEKTGSLSKKELSQYLQNQKKDEKDGLMNTALADALAKLKQP
(893) DNA topoisomerase [Desulfotomaculum ruminis DSM 2154]
7
MKTLIVTEKPSVAKDIAAVLGRFERKDGYLENREHIISWAFGHLVELADPSVYNPAFKKWQLATLPILPDSFQLVEIAGSVKQLRILKRLLHLPEVSQVVNGCDAGREGESIFRRIYRYSECRKPIKRLWLSETTPAAVKAAFNQLRDGRDYDNLAAAAEARGQADWLVGINGTRAFTLRQGTVLSVGRVQTPTLNLMVVREREIKNFKPSPYWEIWAIFQADQGSYRGKWFRGKEDRLENSEVAQALIRQLTGEGLPVQGRVTSLEQKEVKERPPFLFNLNDLQKEGNRKYGFTAQQILDLAQALYEKHKLLTYPRTDSRHLSKAMLGTLPERLAALKKAPSYAPFVPEPLPELSKRYVDDGKITDHHAIIPTAADPTKASLREAEQKIYDLVARRFLSIFYPEARYAVTEVVTEAGREKFKARGRMELAAGWKILWRDNRNPEKNHDPKGEENEDQSLPPLTREEVVEMTHIESQEKQTKPPKRYTEATLLTAMESAGKLVDNKDMAEVLKQAGGIGTPATRAAIIERLIQVGYIRREKKNLLPTDKGETLIDLAPEQLKSVELTADWEEGLRRMEEGRQEPEEWIKGIKEYTRQLVQFARNQEDAGVAEGKKSLGICPVCRRDVTETPRSYGCTGYKEGCKFAIWKEIAGKKITLKQAEDLLTKGKTGVLKGFKGKSGKPFEAALVIGEGGRVEFAFPDRAQNRSGTNPSMGPAILGPCPVCGKGVVESSKGFGCTGYKEGCKFVIWKEIAQKKIGLTLAKELLTQGRTGMLEGFKSKSGKNFEAVLVLNQGKVEFEFTKR
(1510) DNA topoisomerase 1 [Desulfotomaculum ruminis DSM 2154]
1
MSKTLVIVESPAKAKSIGKYLGRNFTVKASMGHVRDLPKSQFGVDIDQEFSPKYITIRGKGDIIKELRSAVKKSDRILLASDPDREGEAIAWHLTKLLDIDEQSPCRIEFNEITKNAIQQAVKNPRPIDQDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREDEIQAFIPEEYWTLMGKFVKSGKSPFEAKLHKYKNKKIEIPNQEMMDKILGDLKGASYQVATVSKKEKQRNPAAPFTTSSLQQEASRKLNFTSRKTMVVAQQLYEGLDLGKEGPAGLVTYIRTDSTRVSETASEEAKKFILDRFGPAYVPKQPRQTVAKGKVQDAHEAIRPTSIERDPENIKQYLTNDQYKLYKLIWSRFLASQMASAVMDTTSLDIAAGDYVFRATGSVIKFPGFMQVYIEGNDDGSKEEERLLPELSEGDKVEAKNLTPKQHFTQPPPRYTDATLVKILEEKGIGRPSTYAPIVDTIQKRGYVVRENKQFYPTELGIVVIDLLKNYFPDIINIEFTAEMEEKLDKVAEGDERWVGILKDFYQPFQETLENADEKIGKVQVADEVTDEKCELCGRNMVIKLGRYGKFLACPGFPDCRNTKPLLEPTGVGCPKCSGEMVLRRSKKGRKFYGCSRYPECDFVTWDVPTQEKCPQCGGMMVEKNSRGKEKRTECINEKCPGKEYKASEQTKKEAGAVSGKTAAKAGKKTPQRNRKKANPSG
(770) DNA topoisomerase 1 [Butyrivibrio fibrisolvens 16/4]
1
MAKNLVIVESPAKVHTIKKFLGSSYEVMASQGHVRDMPKSQLGFDPENDFEPKYITIRGKGELLAALRKEVKKADKIYLATDPDREGEAISWHLTHALNLQDKKVYRITFNEITKTAVKNSLKNPREIDMDLVDAQQARRMLDRMVGYEISPLLWAKVKRGLSAGRVQSVALRIICDREKEIEQFIPQEYYTLDVLLDAAGSKKPIVAKYYGDTSGKKDISDKESLDKIMESLKGASFNIASIKRGTREKKAPLPFTTSTMQQEASKALNFSIQKTMSVAQQLYEGVTVKGYGTVGLITYLRTDSTRVSDEAKAAAESFISSNYGDNYLSESAGNAKKNSGKVQDAHEAIRPANIELIPSEIKDSLTRDQFRLYQLVWKRFVASQMANAVYDTVSLSVSAKDQVFTASESSINFDGFMMIYTAADDEEESKTHPLAKLTEDTKLSFNSFEEKQHFTQPSPHFTEASLVKTLEELGIGRPSTYSPTITTLIKRHYITKEAKNLFVTELGEVVNSIMVDSFPIIVDDKFTANLELLLDGVEEGTVDWKSVVRNFYPDLEKAVKVAEEELAKVEIHDEVTDVICEECGRNMVIKFGPHGKFLACPGFPECRNTKPFLEKIGVPCPKCGGDVVIRKSQKGRKFYGCSNHPECDFISWSKPTTVKCPKCGTYMVEKGNKLVCGNDECRFVQSQN
(189) DNA topoisomerase III, bacteria and conjugative plasmid [Ruminococcus obeum A2-162]
7
MKLVIAEKPSVAMSLAAVLGATERKDGYLEGSGYLVSWCVGHLLELAQPEAYKEQYAKWRYEDLPILPENWKYEVPKDKKTQLALLCRLMKDKRVDSVVCATDAGREGELIFRLVYEYAGCKKPMERLWISSMEDAAIREGFDHLHPGSDYDKLYDAAVCRAGADWLIGINATRLFSVLYGVTLNVGRVMSPTLALLVQRESDIESFISKPFYVPEITCGGFTASGEKMTERSEAEKIRMDCDHNSAFVRSVEKQVKTIQPPRLYDLTTLQRECNRIYGYTAQQTLDYVQSLYEKKLATYPRTDSQYLTKDMQATAASLILWLRDNMTFGKGYAGEPDIDRVTDDSKVTDHHAIIPTVEIARTDLSELPSGERDVLTLLAVRLLCATTQVHRFEAVTAILDCQGYTFTAKGKTILQSGWKEVERIHRMSIRQSETERRENEDAALPVLKEGQTFETVSASLREGKTSPPKHYTEDTLLSAMETAGAEDMPEDAERKGLGTPATRAATLEKLVSAGFVQRKKKQLIPTEKGKNLIAVLPDNIKSPILTAEWESMLKQVEHGELSATSFMDQIADMSRTLVKEHTTPEERFADLFPSSKGTAHEAVGVCPRCGAPVFEGKKGFFCGNRECSFALWKDNRFFSSKKKSITKSVAAALLKEGRISMSGLYSEKTGRTYDAEVILDDTGGKYVNFKLEFPVKKGRRK
(658) DNA topoisomerase [Ruminococcus obeum A2-162]
7
MSKFLVIAEKPSVAQSYAKNLSAYKKEDGYLEGESCIVSWCLGHLAEYAQPEEYDPKYEKWQFDDLPILPQVWKLKVSRDKKKQFDVLKSLMNRADVDYLVNGCDAGREGELIFQRVYDLAGCRKPVKRLWISSMEDTAIRTGFQTMKGAEEYRNICMAAVCRAQADWLIGMNGTRAYTTCYFKRLVVGRVQTPTLAMLAERQDKIEHFQKEAFYKVALTDGRLTVVSENIANEEAADLLASLCMGSEAVITQVKKEQKKAFPPKLYDLTSLQREANRYFGYTAKKTLDMLQELYEEKLVTYPRTDSQFVTEDMRDTVEELVGKMPVLLPFLDYGQLGHNITRVINNAKVSDHHAILPTKEAVEKGISDLPADKKNLMMLVCQQLVQATGEEYQYEQTDITVKCQEHDFTARGKVPVQMGFKEAGNAFKNQCVKAKPEEETEKETSIPYSYEEGMTLSPVKAEKTVHFTSPPKPFNEDTLLAAMETAGNKDFDSETEKKGLGTPATKAGIIEKLVSSGYAVRKGKQILPSTEGRELVNVMPAYLKSAAMTAEWENQLLMMEKGQITDTQFMGEITSLVGKILSVCREIPEVERRRFQKAREVIGKCPVCGSDVYEGKQNFYCSNRQCDFALWKENRFLGSMEKTLDKKMAVELLDKACTHVKGLYSRKKDIKFDADLLLTLEDGKPRFHLEFPKKKKK
(1000) DNA topoisomerase [Ruminococcus obeum A2-162]
7
MAKFLVIAEKPSVAQSLAKNLSAYQRKDGYLEGNSCIVSWCLGHLAEYAPPEIYDEKYAKWQFEDLPIIPKVWKVQVSEDKKKQFDVLCNLINRADVAYLVNGCDAGREGELIFKRVYDLAGCQKPVKRLWISSMEDEAIQKGFQSLTDGREYAGLCNAAVCRAQADWLIGMNATRAYTTRYFKRLVVGRVQTPTLAMLTERKEKIEHFKKEAYYKVSLSDGKLMVTSESIPLEMEAEELRKLCDGTEALVTRVKREQKKTFPPKLYDLTSLQREANRFFGYTAQKTLDMLQELYEEKMVTYPRTDSQYVTEDMKETVKMLAEGMTGFLPFLESGQTRGNIDRVVNNAKVSDHHAILPTKEAMEKGMGGLSSGKKNLLMLIGQQLVQATGEEYLYEQTEISVQCKEHEFAAKGKLSVQMGFKEVEEAFRKYCVKDKKSDEPDNKTELSEGYEEGMILASVKAEKSTHYTSPPKMFTEDTLLAAMETAGNKEFDSETEKKGLGTPATRANIIEKLVSSGYAERKGKQILPTVAGCELIHVMPENLKSASLTAEWENLLLMMEKGKIQEDEFMNGIVSMINEILSLCRAIPEEERNRFQTAREVIGKCPVCGSDVYEGKTNYYCSDRSCQFALWKSNRFLESMKKSMDKKMAVELLKKGRTHVKGLYSKKKDSKFDADLVLGVEEGKARFSLEFPKKKK
(1705) DNA topoisomerase [Ruminococcus obeum A2-162]
7
MGKSLYIAEKPSVAQEFAKALKINGQRRDGYLESEDSVVTWCVGHLVTMSYPEKYDIKYKRWSLDTLPFLPHEFKYEVIPGVQKQFNIVKGLLNRPDVETIYVCTDSGREGEYIYRLVAQMAGVKDKNQRRVWIDSQTEEEILRGIREAKELSAYDNLADSAYLRAKEDYLMGINFSRVLTLRYGNSVSNYLNSRHQAISVGRVMTCVLGMVVRREREIRSFVKTPFYRVLSSIVLEGERFEGEWRAVDGSRYFQSPYLYKENGFKEKKHAEELIGMLQAQQPLSCRVEKVERKKENKNPPLLFNLAELQNVCSKLFKISPDETLRITQELYEKKLVTYPRTDARVLSSAVAKEIYKNISGLRRYPAIDNAAEEILQMGSYKSIAKTRYVNDKQITDHYAIIPTGQGMNALNGLSLTSQRVYETIVRRFLCVFCPPAVYQKVSLTTEMQGEKFFSSFKVLQEEGYLKYATNSFAKKSLAEKETEKNDEEDVSCDSQLLNALQALKKNDILTVDALNIKEGETSPPKRYNSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLVSIKYLSLNKKTQVITPTLLGEMIFDVVNCSIRSLLNPELTASWEKGLTYVAEGSITPQEYMDKLEHFVRVRTNQVEQSNYQYALRQFFDAAAANYTKKPTTVKRGGKA
(239) DNA topoisomerase [Ruminococcus obeum A2-162]
7
MKLVICEKPSVGAAVAAALGVREKKDGYIEGNGYVISWCIGHLVGLAEAAAYGEQYRKWSYDSLPILPQEWQYTVAADKGKQFKILKDLMQRSDVSEVVNACDAGREGELIFRFVYHQAGCKKPFTRLWISSMETDAIKSGFDNLKDGRRYDALYHSALCRAKADWLIGINATRLFSCLYGKTLNVGRVQTPTLKMLVDRDAAIMNFKKEKYYHVRLMLPGAEAASAKICAADEAGKLKAACEASAAVCTSLTRENKTAIPPKLFDLTSLQREANRIYGYTAKQTFDLAQTLYEKKLLTYPRTDSNYLTDDMGDTAASIVSLLCGKLPFMASAAYEQSISRVLNSKKVSDHHAIIPTMEIAKTDLTTLPESERNILILTGARLLMATAEPHVYEAVTAVFSCADHEFTARGKTVIAAGWKNIERLYRATLKKKPDSDDENELVLDVPDFTEGQTFENPAAKVTEHETTPPKPHNEASLLSAMERAGNEDTDPDAERRGLGTPATRAAVIEKLVKGGFVERKGKQLLPTKDGTSLVCVLPDSLTSPQLTAAWENNLTQIAKGNADPAAFMQGIEAMAQELVKTYASVLGEKQELFKTEKTELGKCPRCKSPVYEGKKNYYCSNKECSFTMWKNDRFFEERKTVFTPKIAAALLKSGKAKVKKLYSVKTGKTYDGTVLLADTGGKYVNYKVTISKDKELE
(415) DNA topoisomerase 3 [Ruminococcus obeum A2-162]
2
MKSLVIAEKPSVARDIARVLHCNQKGNGILEGKEYVVTWALGHLVTLADPEEYDKKYVKWDMETLPMMPEKMKLVVIRQTSKQYQAVKDQLFRKDIGDIIIATDAGREGELVARWILDKSGCRKPIRRLWISSVTDKAIRDGFHNLKGGREYDNLYRAAVARAEADWLVGINGTRALTCRHNAQLSCGRVQTPTLAIIARREEEIRKFQPEEYYGVTLQAGGIQWTWKDTRSGSYRTFQKDRAEDIRKNISDGVLEITSVAKKPKKTYAPGLYDLTTLQREANQKYGFSAKETLNIMQRLYENHKVLTYPRTDSRYIGKDVVPTIKERLKACGTGPYRKLAGVLISKPIQTNGGFVDDKKVSDHHAIIPTEQFVQLDHMTNEERKIYDMVVRRFLSVLYPAFEYEQTSLEAKAAGQTFAANGKTVIRAGWKAVYEEGMQEEDTEDNALKDQKLPVFRQGEKIHIDSVRLTNGKTKPPAHFTEATLLAAMENPVKYMSTKDSQAAKTLGETGGLGTVATRADIIEKLFHTFLMEKRGNEIYLTSKAKQLLELVPEDLKKPELTADWEKKLSDISKGKLKQKVFLDGIREYTEEIVGEIKTGTGTFRHDNLTNKICPNCGKRLLAVNGKNSKMLVCQDRECGYRETISRTTNARCPKCHKRMEMLVKGKEETFVCACGYKEKLSSFQARRAKEGAGVNKRDVQKYLKKQQKEAAEPVNNAFAQALAGIKLD
(1027) DNA topoisomerase 1 [Ruminococcus obeum A2-162]
1
MAKYLVIVESPAKVKTIKKFLGSNYDVQASNGHVRDFPKSQFGIDVENDFEPKYITIRGKGELLANLRKAAKKADKIYLATDPDREGEAISWHLMQALKEDPAKMRRISFNEITKTAVKASIKQPRDLDLNLVDAQQARRMLDRMVGYTISPLLWVKVKRGLSAGRVQSVALRIICDREEEINSFIPEEYWSLDGEFKIKGEKKPLQAKFYGTDKKLPIHNKAEMDKILKALENAQYEITEVKKGERTKNAPLPFTTSTLQQEAAKTLNFSTQKTMRLAQQLYEGIDIKGSGTVGLISYLRTDSTRISQEADQAAREYIEAQYGDNYVSTTGKTVKKEQKIQDAHEAIRPTDITRLPAMIKESLSRDQFRLYQLIWKRFTASRMSAAKYETTSVKIGAGEYTFTVAASKIVFDGFMSVYVQEEDNQKGNVLSQSLEKGMKLELTELKPEQHFTQPPAHYTEASLVKALEEQGIGRPSTYAPTITTIISRRYVSKEQKNLYVTELGEVVNNIMKQAFPSIVDVRFTAMMEGLLDCVEEGTVQWKTVVRNFYPDLKRDVDAAEKELEKVEIQDEVSDEVCDVCGRNMVIKYGPHGRFLACPGFPECRNTKPYYEKIGVACPKCGKDVVLKKTQKGRKYYGCIDNPECDFMSWQKPSAKKCPKCGSYMVEKGNKIVCSETTCGYVEQKSKED
(1430) DNA topoisomerase 1 [Alkaliphilus metalliredigens QYMF]
1
MAKSLVIVESPAKAKTIEKFLGKRNYIVKASVGHVIDLPKSKLGVDIDKDYEPQYITIRGKGPVLKEIRTEAKKAKRIYLATDPDREGEAISWHLANALNIDKNEACRIEFNEITKNAIKSAIKTPRKINHDLVDAQQARRVLDRLVGYKISPLLWQKIRRGLSAGRVQSVATKMIKDREVEINAFQPEEYWSLILQVQNMQKEKFEVKFQSDHLGNKDIKSEDEINIIINKIKDKQLMITEVKQGEKKRNPSLPFTTSTLQQEASNKLGYSTKKTMSLAQQLYEGIELGKEGSVGLVTYIRTDSTRISEEASQHVAQYITEKIGEHYLQKSTIVKKGKKSVQDAHEAIRPTDVTRSPDVMKPYLKKDQYKLYKLIWERFVASRMEPALFDTLSITLDVEGVTFKANGSRLRFEGFLKVYSLASRSEDTDLPVLNKDELTSIVEIDPKQHFTQPPPRYTEASLVRAMEEQGIGRPSTYSPTIATILSRGYVEREGRNLLPTELGILVTGILEDFFSQIIDVHFSAELENQLDEIEEGKKGWKSLIEDFYPSFEEMLKVAEEHIEEIHLVEESDEICDQCDAPMVIKHGRYGKFLACSSYPDCTFTKPIVHKIDVKCPKCEDGEIVERKSKKGRLFYGCSGFPSCRFVSWAKPINEKCPQCNEILAHKKTKKSEKITCTNSECKYERLIEDENEK
(697) DNA topoisomerase [Alkaliphilus metalliredigens QYMF]
3
MSKSLYIAEKPSVALEFAKTLNIKGNKKDGFIESNEAVVTWCIGHLVTMSYPDKYDDKYKKWVLKDLPFLPNKYKYEVIKNVKKQFDIIKTLMKRTDISTIYVCTDSGREGEYIYRLVDEMVNVKGKTKKRVWIDSQTEEEIKKGVKNAKPLDEYDNLANAAYLRAKEDYLMGINFSRLLTLSYGSALSKRLGKKYVVIAVGRVMTCVLGMVVQREREIREFVKTPYYKIISNFQLDQSMDYDGEWKAIESSNYYMSDLLYKDIGFKEVKSAEKFIRELKEDNTELTAVVETIKKKKETKNPPLLYNLAELQNELSKKLKINPDETLKVAQKLYEKKMITYPRTDARVLSNAVAKEIHSNLKGLLRVKQSCQLEPGDEGINDFIQKIVNEGLYKELQKTKYVNDKAITDHYAIIPTGEGLGSFNRLTDYEKETFLLIVRRFLAIFYPPAIFSQLSITTKIKTESFFTTSKVCIQEGYLEILNDGKKDGASSLDKEETLKKLKKGQTVKINKLEIKESETTPPKRYSSGSIILAMESAGKLIEDEELREKIKGSGIGTSATRSGILNKLQQISYIALNKKTQILTPTSLGESIYDVVDESIPSLLKPELTASWEKGLGMIANGEIQCDEYMIKLEAYIRKNTQKVLKLSNQPNLLNSRSIKSTTNKGNQDTKGKRVGRLALGKCIACETGEVLENSKAFYCSNWKQNCKFTVWKDSLKRYEQEIDEEMIKALLEKGQIDKVSIVLPQTNEKCTASLEFKDNKKGELQLKNVTPTTE
(354) DNA topoisomerase 3 [Alkaliphilus metalliredigens QYMF]
2
MKKKLVLAEKPSVGRDLARVLNCNQKGNGYLEGKEYIVTWALGHLVTLADPETYSQKYKSWKLEDLPMLPDEMKLVVIQKTGKQFNAVKSQMVRKDVGEIIIATDAGREGELVARWIIEKVGVKKTIKRLWISSVTDKAIKDGFNKLKNGREYDNLYASAVARSEADWIVGLNATRALTTKYNSQLSCGRVQTPTLTIIAKREEEIQRFQPKTFYGAQVVAGDLKLTWQDQQTNSMRVFDETKIDQVIQSIQNQEVKVVDISKRHKKSYAPRLYDLTELQRDANKIFGYSAKETLSIMQKLYETHKALTYPRTDSRYITADIVGTLKDRLQACGVGPYKAFAAKVMQSSIKANKSFVDDAQVSDHHAIIPTEQSIYLGALSDQERKIYDLVVKRFLAVLYPPFEYEERTINAKLGKEHFIAKGKMVIHQGWKAIYGHQTEVSEDEDIADQILPNLNRGDTLKVNAISKTTGKTKPPALFTEGTLLTAMENPSKFMSNEDKTLIKTIGETGGLGTVATRADIIEKLFSSFSIEKRGKDIHITSKGKQLLQLVPEDLKSPGLTAEWEQNLSAIAKGKLNKNTFVNRMKEYTKTIVKEIKNSEAAFRHDNLTANKCPDCGKYMLEVNGKKGKMLVCQDRECGHRKIVAQKSNARCPDCKKKLELRGEGEAQIFVCSCGHREKLSTFKERRKKDQDKASKGEVNQYLKQQKKEEPINTALADALAKLKLD
(446) DNA topoisomerase [Eubacterium rectale ATCC 33656]
3
MGKSLIITEKPSVAQEFAKVLRVSGRNDGYIENGEYVISWCVGHLVGLVYPESYDMKYKKWRLEDLPFLPKEYKYDVIDSVRKQYNIVHALLQREDIDRVYWAGDAGKEGQTIEENIRNFGGVREGMEELRVWIDSQTEEEILRGIKEAKPMSAYANLGKSGIMRTIEDYAMGINFSRVMSVKYGNLLNDAAGTRSYTAIAVGRVMTCVLGMVVIREREIRNFKETPFYRVIGRFTDAGVEAEWKAVEGSRYFESPLLYKENGFKEEKDALALIEELNGKQAKIKSIVKNITKKRAPLLFNLAELQAECSKKFKISPDETLQVAQDLYEKKLTTYPRTDARVLSSAVAKEIGKNIGRLKGFEPTADFVEHIMQKRLYTNIADTQYTDDSKVTDHYAIIPTGQLTELSGLTSLQRAVFELIVRRFLSIFYPPAEYENVKLVVDVDKESFFASSKVLKSEGYLQVANPPKKKSFEESNARILGKNSETADSTDENSTANGSNDEIVVNPKVMLELADKLKAGDEIACQGYNIKFGKTSPPKRYTSGSMVLAMENAGQLIEDEELREQIKGSGIGTSATRAEIIQKLVRIGYLNLNKKTQILTPESLGEMVFEVVYMTVPALLNPKMTANWEKGLDGITRGTVDFWEYRGKLESFIRKETEKMIEQNLRPEIADRISSFAGKNARGAAARRKIGVKCPVCGGEIVTTPFGYGCANYKNDKSGCNFNIGQVAGLDIPEEQVKKLIEEGITDTIRGFKSKSGKRFDACLKLNKDEQTNKVSATFDFENVKPQKVEGIVCPDCGGDIYVSPYGYRCANYNRQTEDGCHFFVGRIADKQLSQVQFLELMANGRTETIKGFKSKSGKRFNACLVLKKEPVTEGSEKMHTVVAFDFDNVEDEIIKDVVCPLCGGQIKKTSFGYGCVNYKGDEPGSCRFSVGQIAGKTITAANLKQLLNDKKTETIRGFKSKSGKRFDACLVLKEDENKKLSVQFDFDHVEPKTVKDVVCPKCGGKIQVAPFGFVCENNRRDDPESCRFMVGKVASVKIKESVLKELLTKKKTEVISGFVSKTGMKFDAPLKLTEDGDIAFDFPEKPKPIETNVLCPKCGRPLKKTQWKYECECGFNVWHTVAKVELSEEILTELFTTGKTKKKVTGFTSKAGNVFDTCLKFENDQISFDFDNPGEEEVQSTAEVHNNADAHNNADAQSNADAYNNADTQSNTDAHNNAEVQSTADDAPDETTLNEMGIPEEFLAGFDMAADSVQADDVSEAALAAAHELFGE
(451) DNA topoisomerase 1 [Eubacterium rectale ATCC 33656]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVMASNGHVRDLPKSSLGIDVDGDFEPKYITIRGKGEILAKLRKEAKKADKIYLATDPDREGEAISWHLLHALKLEGKDVSRISFNEITKNAVKESLKHPRKIDMDLVDAQQARRVLDRIVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWSLDATVDVEGEKKPITAKLYGRGDNKIAISSKEEMDKVLNEINGKDCKVQNIKKGQRSNKAPLPFTTSTLQQEASKALNFPISKTMRIAQQLYEGVDIKGQGTVGIITYLRTDSVRVSDEAEAMAKDFISKSYGDKYLSNGEGTKKSSKNIQDAHEAIRPTDINRVPSEIKESLSRDQFRLYQLIWKRFTASRMAKSEYETTTVKLSVGDYVFSFATSRLLFDGFELAYTAADDAKKEKQPVLKNPLTEESLLTVEELLPKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTISTILARRYITKESKNLYVTEIGEVVNSIMKESFPTIVDEHFTANMESLLDAVAEGKVNWKTVVENFYPDLKDAIDKAENELEKVTIHDEVTDEICPECGRNLVIKYGPHGKFLACPGFPDCRFTMPYLEKIGVNCPKCGKDVVLKKTRKGRKYYGCIDNPECDFMSWGRPVAEKCPRCGGYMIIKGNKIACADEQCGYVTDKKPEREE
(736) DNA topoisomerase [Eubacterium rectale ATCC 33656]
7
MKLVIAEKPSVAMALASVIGARTRKDGYVEGNGYLVSWCVGHLVGLCDASEYDEKYKKWRYEDLPIVPECWKHRVLEGTKKQFGILKKLMRDSKVDEVICATDAGREGELIFRLVYEQAGCKKPMKRLWISSMEEQAIKDGFASLKDGSCYDSLYQSALCRAKADWLVGINASRLFSVLYNQNLKVGRVQTPTLAMIVDRNQKIKEFTKEKYYMAHIKFDEMDAVTEHFQKKEDADRVAADCMERMCEVEKDDVKEKTVRPPKLYDLTTLQREANRMFGYTAQQTLDAVQEMYEQKLVTYPRTDSQYLTDEMGESTETLIQMLLGKMPYAEGLEYHPDVSKVLNSKKVSDHHAIIPTMEVAKADIGELKERNRKILYLISARVLTATADPYIYESHKCQITCNYHTFYLTAKKTKQEGFKAIENKLKQFFGVKIEKEEPELDIWAGKHYGPCDSLVSEHFTQPPKQYTEDTLLSAMERAGNEELTEDTEKKGLGTPATRAAIIEKLIQSGFVKREKKNLVPTDDGNVLITVLPDEIKSPKMTAEWEMALNHIAQNTETADEFLNGITELMQELVARYQGISEEKKNQFQGKAKGEVIGKCPRCGADVQEGKVNFYCSDRNCTFTLWKNDKFLASQGKKMDKTAAKKFLSKGKIHYKDLVSRKTGRQYEATVEMVDPGEGNVQFNLIFPQR
(283) DNA topoisomerase [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
7
MKSLVLAEKPSVAREIARVLQCSKKSKGYIEGPRYVVTWALGHLVTLAEPDDYDKRLKQWRIEDLPMLPEKMKLKVIKQTSHQFQVVKELMKRNDIEELVIATDAGREGELVARWIMEMVRWRKPFKRLWISSQTDNAIREGFARLQPGTQYNSLYAAAACRAEADWLIGLNVTRSLSCKFNAQLNAGRVQTPTLAMIVKREKEIKAFVPRDYWTIRADFGDYYGDWRGKDGGRIFDYARAEEILSRIKGRMAAIKEVKTEARSEAPPLAYDLTELQREANRRLGWSAQKTLSILQELYEVHKLVTYPRTDSRYITDDIVPTLPLRLKSMGVGPYADLAHPLLQKPLKPGKRLVDNSKVSDHHAIIPTEQPLQLKSLNEEERRLYDLIARRFLAVLYPPYRYEQTTIITVVEGENFHSRGKVEIDRGWRAVQAVPSDKDEKDEEQLPEQTLARHKKGETLEVKSGKASKHKTKAPARYTEATLLTAMENCGKLVEDKKLRESIKGSGLGTPATRAEIIEKLIRTSYIERQRKELVPTSKGIQLMDLAPPDLRSPELTAQWEQRLAEIARGQGKRLDFMADIRRDTVQLVQNIKSDSSSTYRADNVSKSKCPQCGRFMLLVNGRKGKILACPERSCGYRQPEAEDFSGKGGNSRANRRLMAKYSNQEELETNLGELLKAALAKKEQG
(97) DNA topoisomerase 1 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
1
MAGTTLLIVESAAKARTLGKFLGKGYKIKASVGHVRDLPKSKLGVDVENDFEPQYITIRGKGDILKEIKDESQKAGRVLLATDPDREGEAIAWHLQNAMKIPPEENCRIEFHEITREAVKKAIKNSRPVDLSRVNAQQARRVLDRLVGYNLSPLLWNKIRKGLSAGRVQSVALKLICDREEEIKNFIPQEYWTVDAIFNAAKGKNSKFTARLASYQGKKIEINSDKEVAAIGEYLQGANFTVLKVERKEKRKNPNPPFITSTLQQEASRRLNFFSNRTMRVAQELYEGLEIGKEGTVGLITYLRTDSTRVASSAQMEALDFINSTFGAEFAPDKPNEYKSRKSAQDAHEAIRPTSIQRTPESVKAFLSRDQYRLYQLIWNRFVSSQMTPAVYDSLTVDISAGDYGFRASSSQLKFIGYKKVYSDNEEEEPKNNIPELKKGEELALHELKPEQHFTQPPPRFSEASLIKLLEEKSVGRPSTYAPTIDTILKRNYVERQNRQFIPTELGFIVVDLLKEHFANILDVEFTARMEGELDLVEEGKLDWKKVVRDFYEPFHSDLEKARELAQKIEIKDEEAGKECPQCGRPMLIKHGRFGKFMACSGFPECRHTQSINQELGLKCPLCQGSIVALKSKKGRTFYGCSNYPQCNFRSWDKPTGKICPHCGDAIVEKFNKKKEATQICQNPACKQKVEMGG
(420) DNA topoisomerase 1 [Syntrophothermus lipocalidus DSM 12680]
1
MLVIVESAAKAKTISKFLGRNYKVLASVGHVRDLPKSKLGVDVEHGFTPQYVTIRGKGEILKHIREESEKSSRVLLATDPDREGEAIAWHLSQAMNLKDKNPCRIEFNEITKDAVTRAVKKPRPIDMNRVNAQQARRVLDRLVGYSLSPLLWNKIKKGLSAGRVQSVALRLICEREREIESFVPEEYWTIEGEFAAGNKALVARLVARGREKLEIGSREAVDAILAELETARFTVSKVEKKTKKKNPVPPFITSTLQQEAYKKLGFTASRTMRVAQELYEGLSLGEGGTVGLVTYIRTDSSRVAEEAQKEALDFVEQTFGKEYRPEKPNVYKSKKTAQDAHEAIRPTSVWRQPERVKTFLTRDQYRLYKLIWERFLASQMAPAVYDTVTVEITGGGYVFRASASNLKFPGYLAVYQESENEEEDEKRAIPEVQEGQELVARGFKPEQHFTQPPPRYTEASLVKMLEEKNIGRPSTYAPIVDTILRRGYVERKNKQFVPTELGFIVVDLLKDYFPEIMDVEFTASMEENLDRIEEGELNWQETVEEFYVPFSDKLRKASSEIEKVELKPEEAGKDCPVCGKPMVIRNGRYGRFLACSGFPKCRYTESVNEETGITCPQCGRKVIALRTKKGRRFYGCEGYPQCDFRSWNLPTEKKCPQCGGPMVRKRGRGQEYLACTSKECRYEEKEARM
(314) DNA topoisomerase 1 [Caldicellulosiruptor kronotskyensis 2002]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAQEAEKVYLATDPDREGEAISWHLATILGLDTNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDVQEFKAKFYGDKKGKIELKNQDQVQKIEEKIKNKEFKVVKIKVSEKKKSPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRVSEEAQQAARSLIVQKFGKEYIPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFRLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGETLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVAKEDRFLKPTELGRIVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVKKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPVKNCPKCGSLMFEKGKKGNKKLVCSNENCAYQEKTGEKGE
(1218) Reverse gyrase [Caldicellulosiruptor kronotskyensis 2002]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEKCLKDDHLTENVFELLKGCGLLKDYQIYWNFHQNYKMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTVSLAQQSFERLNQFKSKIQNTDVIRILLFNSSMKKSEKEEFEQRFLSQDFEILIVTSQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNRENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENSIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFSIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEILQTEKLRQLVSKYISKEDYSKIVNKIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFDSLKSRLMFLLDEEWMEENEVDFESLMEEVKESRKIQNDDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITQDGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKDILKTLRELALEVDEVLIATDPDVEGEKISWDISQYLKPANSNIKRIEMHEITRYGLDSALKSPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKNYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEEECKKVEAEVVEQKIEEIPAPAPFTTSSLLSLASQKLNLGVQQLMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKILVQKVHFRINDIEIVKDIPVKVEEEGWLEFIPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLQELYNDISVLLNK
(480) Reverse gyrase [Caldicellulosiruptor owensensis OL]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEKCLEDDHLTENVFELLKGRGLLKDYQIYWNFHQSYKMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFSALHGKKSALVFPTISLAQQSFEKLNQFKSKIKNADAIRILLFNSSMTKSEKEEFEQRFLSQDFEILIVSSQFISKRKDVLSKMFFNLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLKNKNKENGQNTNLNTLKDKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSREKLLEIINILKDGILLFVNTEEEGKEIVKFLAENGVKIGTTWSNFDEEFELFKEGKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPSFRFSVDMDKAPRFVLERVFVEYLEDHPKLKEYFKNVETLQTEKLRQLVLKYISAESYNKIVQEIFSHLKITDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMDESEANFESLMVEVEESRKSRNEGFNVNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEFHDGKFIPYYNSIKRCTKCYTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNTKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFQSYNLSAGRVQSTILGWIVEREKEYAKSERTFTMLKLENGYNLEIEGEEECKRVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRNFGDEGAHEAIRPVKPISPEELKELVYEKYAQGVSQNHIKVYQLIFNRFLSSQMKNPKVLFQKVCFKIADKEIVKDIPVKIEEEGWLHFLSMQIYPLFENKDYSVTDRRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSLKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILSELFNDLKNLLEN
(244) DNA topoisomerase 1 [Caldicellulosiruptor owensensis OL]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDNQEFKAKFYGDKKGKIELKNQGQVQEIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAIAQMLYEGVEIKGEGSIGLITYMRTDSTRISEEAQQAARNLIMQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTPDQYKLYKLIYDRFLASQMESSIYDVLSAELEVEGYVFRLTGSKLKFAGFMEVYVEGKDTEDEEEESQLPEISEGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTDVVRKYYQPLEKELEIARNTMNKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYHCLEVLCPKCRKRIIERKSKKGKKYYTCEEYPACDLILWEKPVKNCPKCGSLMYEKGRKGNKKLVCSNENCLHEEKIGEKGE
(1609) DNA topoisomerase 1 [Halothermothrix orenii H 168]
1
MGNKSNNTLVIVESPAKAKTISKFLGKGYKVEATMGHVIDLPKSKLGINIDKGFEPRYITIRGKGKVLKKLRKEVKKSKDVLLATDPDREGEAISWHLTRALKIDEDKPRIEFNEITKSAIKNALKNRRPIDKNLVNSQQARRLLDRLVGYKLSPLLWKKVRRGLSAGRVQTVAVKLLCNREKEIESFEPEEYWTISASFNKKDKDFIADLYRISGKKFKINNEKEAKQILEDLNKSKFVVSDIKEKTRKRNPNPPFTTSTLQQRASSILGFSAKKTMYLAQQLYEGIDMGSEGTTGLISYIRTDSTRISREAQKQALDYIKEAFGDKYIPDKVKVYKAKEGSQDAHEAIRPTSVDRTPGKVKKYLNKDQYRLYKLIWERFVASQMSPAQYKQVKVLIKAGDKYIFRAKGSRIIFPGFLRVNTSSQKKDIILPPVKKSERLDVKEIKPEQHFTQPPPRYTEATLVKTLEEEGIGRPSTYAPIISTIISRGYVERQGKQLKPTELGFIVTDLLSKYFPDVTDIEFTAHMEERLDKIEDGKDEWRNVLEDFYSNFSRRLKEASEEMEEVKLEDEVTDEVCEKCGRNMVIKYGRYGKFLACSGYPECKNTKPYVIKTGVKCPQCKEGELVQRKSRKGRTFYGCSSYPDCKFVVWNKPVKEKCPECGGLMVEKNSKKQGRYYLCINKECGYKKEV
(115) DNA topoisomerase [Symbiobacterium thermophilum IAM 14863]
7
MAGKPLIIAEKPSAAMAIAQALGGFQRRDGYLESAEYLLSWAIGHLVELLPPEAYDPRWKRWTMETLPILPEGFGLHVLPKTRSQFRTLARLGKQAPLLVNACDAGREGELIFRYICAAAGLEKPVMRLWVSALTPAAIRAAFAEMKPQEHYDRLYRSARCRAEGDWLVGINATRAFTVKFGELLSAGRVQTPTLAMVVRREREIESFRPEPYWEVFAAFRTPDGREYTGKWFGPDGDRLSSADAAEAVVRRVRRQAGWVEASDERPVAERPPQLFDLTSLQREANRRYGLTAAATLKAAQALYEAKHITYPRTDSRYLSRALVPQLPALVRALSARSDLAALAAGADLSRVGFGNRRVVDDAKVTDHHAILPTSEVPRSLTGAEAKIYDLIVRRFLAQFYPDARFLEQEVVTCVGELPDRFRSRGRRLVDPGWRQVEPEPARKRRAAEDEEEEGLQLLPPLRMGEPVAVGDVESREKATRPPRRYTEATLLSAMEYAGREITDEALREAMKGHGLGTPATRAAIIERLKEMGYIITERRSLVPTAKGRRLVELAERAGVEVLLSPELTGEWEHRIAGIQSGEYDDARFMQEIRELTARLVERIRATEGAPGRGGAGRSSTAEPGPAKEEPAAGGPPLQDRLPTPCPRCGGPVTRGSRGWTCATAGCGLRIPTFLCGKVIDGGAAEALLSRGRTPLITGFTSPRTGRRFSAFLVLKEDAQVGFEFPPDRRGSRRTRKAPGEGDAPSRGPGEAETSSPNRSDGASAGVSPRRGRPGSRAGARKP
(1530) DNA topoisomerase 1 [Symbiobacterium thermophilum IAM 14863]
1
MPKSLIIVESPAKAKTIEKFLGRKYAVKASMGHVRDLPKSQLGVSVENDFEPKYITIRGKGDILKELRESARKADRVYLATDPDREGEAISWHLAQVLKLPLDEPLRIEFHEITKDAIQRAIKQPRPIDLNRVEAQQARRVLDRLVGYKLSPLLWRKVRRGLSAGRVQSVAVRLIVDREREIQAFQPEEYWTLDARLSTAFAQSFSARYWGMGEQKADLKTQDQVRAVVHQVAGDRLPAGNAAVSGEGTPGDPFTEVLDLAGEGLVLQVRSVKRREKKRNPAYPFTTSSLQQEASRKLGFSVRRTMAVAQQLYEGLPLGEEGHTGLVTYIRTDSTRIADEAARAAAEFIERQYGKDYVPERRREPDRRAGEQGAHEAIRPTDVTRTPESVKPYLTPDQYRLYRLIWERFLASQMAPAVLDTVTVELVAGEHVFRASGQSIRFPGFMKVYIEGEDDDGQREEGDDLLPELAEGQQVTLQTLEARQHFTQPPPRYSEAMLVKALEERGIGRPSTYAPIIGTIQTRGYVEKRDKRFYPTELGVLVTDILKEYFPDIIDVEFTAHLEGKLDEVEEGRVNWRELIRRFYGPFEETLKQAEEKVGGFELEDEVSDVPCEKCGRLMVVKHGRFGKFLACPGFPECKSTKPILEETGVTCPACGTGRIVERKSKKGGRRFYGCTNYPDCNFVSWEKPVNRLCPECGAPYLVEKRIKELGLSHVCKQPDCGYVEPVESMEEVHA
(1212) DNA topoisomerase 1 [Thermoanaerobacterium thermosaccharolyticum DSM 571]
1
MEKSLVIVESPSKAKTIHKYLGKNYKVEASMGHIRDLPKSQLGIDIEKNFEPKYITIRGKGPIIEKLKKEAKNASKIYLATDPDREGEAISWHLANLLNIDVNDKCRIEFHEITKNAIQNAIKNPRKINMNLVDAQQARRILDRLVGYNISPLLWKKIKRGLSAGRVQSVATRLICDREKEIEEFKPEEYWSLSAFLYKEKKTQYFEAKFYGTKDGKIDLKNENDVNNIIKDLADDYIVDNVKTGTKKRNPSPPFITSTMQQEASKKLGFTAKKTMMIAQQLYEGVEIKGEGSLGLITYMRTDSTRISEEAKKAAYEYILQKYGKEYANPNTTYTKKGGNIQDAHEAIRPTYINLDPDQIKDSLKPDQYKLYKLIWSRFLASQMSQALYDTITMDIINKNYIFKASGSKLKFAGFMTVYIEEADTENIEEKTLPLLEKGDHLKLKVLKPEQHFTQPPARYTEATLIKELEEKGIGRPSTYAPIISTLLERGYVIKEKKNLKPTELGFIVTDVMKEFFPDIVDVKFTAEMEEQLDKIEEGIEKWCDVIDGFYNNFNDSLKVAEEQMKDIEIKDEVTDIKCEFCGRNMVIKYGRYGKFLACPGFPECKNTKPLYEETGIICPKCGGKIIVKKSKRGKTYYACENSSQCGTMFWDKPINETCPKCGNLLMEKYIKGNKVIKCSNCDYVK
(209) DNA topoisomerase 1 [Clostridium thermocellum ATCC 27405]
1
MADKLIIVESPAKAHTIGKFLGKDYKIVASVGHVRDLPKSQMGVDIENDFTPKYITIRGKGEIISKLKKEAKNASTIYLATDPDREGEAISWHLATLLNIDKNEKCRITFNEITKNAVKNAIKSPREINMDLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTITAKLLKGGVKAPFEAKFYGLDNKKTELKSEEEVNKVLDEIKDAVFVVQKVKKGEKKKNPNAPFTTSTMQQEASRKLGFSTKKTMMVAQQLYEGIEVKGVGAVGLVTYIRTDSTRISEEAQNQAAKYIKEKFGESYLPKEKNVYKNKSASQDAHECIRPTSVEMDPESVKDSLTKEQYRLYKLIWDRFVASQMAPAVYDTINADIEAGKYLFKASGSTVKFPGFTVLYQEDKDDETEEGEVIVPELAEGESLKLKKLEPRQHFTQPPPRYTEASLVKALEEKGIGRPSTYAPIITTILARGYVVKEGKTLVPTELGKIVTDIMKNYFQDIVDVEFTAQMEKTLDEVEEGEKRWVDVMRSFYSQFVDVLKNAEEKIGNIEVPEEVTDEICEKCGRNMVIKVGKKGRFLACPGFPECRNAKPILEDAGVTCPKCGGKVYIKKTRKGRKYLGCENNNSDPKCDFMTWDMPSKENCPKCGSFLLKKYSGRKVQLKCSNENCDYVKTGKEKKEDE
(1294) DNA topoisomerase 3 [Clostridium beijerinckii NCIMB 8052]
2
MSKTLVLAEKPSVGRDLAKVLKCNQNKGSYIEGSKYIVTWAMGHLVGLMDPEGYDNKYKEWKMETLPMLPKHMKLTVLKKTGRQYNEVKKQLLRNDVSDIVIATDAGREGELVARWILEKSGVKKPLKRLWISSQTEKAILDGFRNLKPGAAYENLYKAAVCRAEADWLVGLNVTRALTCKYNAQLSAGRVQSPTLSMIVLREDEIRNFKPKTYYTLEGKTRGFNLAWVNKDNNSRIFDEEFANKVASKLKNSEGKIVNINEANKKKFSPALYDLTELQRDANKIWGYSAKQTLNIMQRLYENYKILTYPRTDSRYITTDIVATIPDRLKAISIGEYRIVAEELLKGKIIGNKSFVDNSKVSDHHAIIPTEQKPNLALLSSEERKIYDLVVKRFLSVMLPPFEYIQTTIEAEVQGEKLVAKGKVIKAKGWKKLYDRLEEDSDEEEIKEQVLPTVSIGNSIRVESVNIKKGETKPPARFTEATLLSAMESPHKYINVSKEAAKTLGETGGLGTVATRADIIEKLFNSFVIEKKGKEIIPTSKGKQLMELVPKDLKSPLLTAKWESQLDEISKGKRDDHSFIKEMKNYSVALVEDVKGTNNKFVHDNKTGKKCPNCGKYLLEVKGKNGVMNVCQDRECGYRESVARVTNARCPECKKKLELRGNGEGAIYVCPGSNCNFREKASQFKKRFEKNGKIDKREVNNYMKKMKKEAEEFDDNPFAALLGDIKFDK
(975) DNA topoisomerase 1 [Clostridium beijerinckii NCIMB 8052]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIENNYTPKYITIRGKGELIDKLRKAAKKAEKVYLATDPDREGEAISWHLANILKISEDETCRIVFNEVTKTAVKASIKQARKIDLDLVDAQQARRILDRLVGYEISPILWKNVKWGLSAGRVQSAALKLICDREKEINEFIPKEYWSIDCTLKKEKKKFPVRLSTYKGKKIEIGNEETSNGIIKELNKGNFVVKSIKKGKKNRNPLPPFTTSTLQQDANRKLNFMTKRTMSIAQVLYEGVEVKNYGTVGLITYMRTDSVRISEEAQESAKEFIEGSYGKEYLPGAPRVYKGKKNIQDAHEAIRPTYVEITPEIAKENLTPEQYKLYSLIWNRFVASQMASCELNTHSIDIENGDYKFKASGSVISFDGFMKIYEYSNEEDENSVMLPELKENEELKVESLNGTQHFTQPQPRYTEASFVKLLEEKGIGRPSTYVPTISTLLGRNYVIREKKNLIPTELGEIVNNIVSEYFRQIVDVDFTADMERKLDDVEEGSENWTQIVEEFFSPLKVAIEKAEKEISKVVIEDKVSDVKCEKCGRMMVIKRGRFGEFLACPGYPECKNAKPIVEELDVPCPECGKPIVAKKSKKGKKFFGCLGYPECKFVSWYEPVKEKCPNCNSYMVAKYSKTKGNYIQCSNSECNYKEEVKKDNSKEE
(1168) DNA topoisomerase [Clostridium beijerinckii NCIMB 8052]
3
MAKVIIAEKPSVAKNIADAFNVKTRRDGYFEGNGYYITWAFGHLLQLYDAKDYDENMKGWRFEKFPFIPEHFLYKVKCDSVDRTVEDKGAKKQLGIIKSLIDKEDVDGIVSATDFDREGQVIADELFGYFKVKKPIYRLLLNEWTPDEVKSGMESLKDNKEMQPLQDAGIGRQWSDWIIGINLTSVSTLKYKFEENKTINIGRVLLPTLKIIYDRDKEIENFTATTYYKLVSNFKTSANEEFEGLYYENDSEKFEKKEDLDKFISRLEGATAKIIDKQTELKKEYPPYLFNLSNLQGHITSKYKGWTSDKVLKVAQSLYEKKLTTYPRTASVVLEESLKDRAKKVLNTLKAGLPYEKDIKFSTSKRIFDSSKVESHSAITPTYIKPSGLSSDEKIVYDAIKNRFIMQFMPIAEFEETKVTLKANVSEMNGIFVSKGKVKLVEGWKVVEKIESKDVILPKIEIDETVDIVDSKVNSVTKKPPKYHTEKTLLRVMETCGKGIEGKDEDSEEMMQAILSGFSIGTPATRAETIKKLKDIGYLKTKGKNLMCTELGRNLVETFPVKELFDLEYTGRLEKTLSDIEKGKFAKSEFIKLITDFTIQSVELIKKDDAALSRFKVEIPKDSENIGPCPVCGNPVIEGEKSFGCSNWKNGCKYTIWKDDRYIASFGKKISKEMVELLLKNGKVGFRNLKSKKGNTFSAYFKYEKNEESGYFNWKIEFIDNK
(1834) DNA topoisomerase 1 [Carboxydothermus hydrogenoformans Z-2901]
1
MKKLVIVESPAKAKTIGKFLGKEYVVKASMGHIRDLPTYRFGVNIEKDFAPTYEIIRGKKELIKELKEEAAKAEKVYIASDPDREGEAIAWHVKEVLDLEDNGDLRIEFNEITKDAVLQAIANPRGIDYNRVYAQQARRILDRIVGYKLSPLLWRKIKKGLSAGRVQSVAVRLICEREEEIEKFVPEEYWSLTAHLEAEKKPFKAKLSKYQNRKIEIKNKDEVERIIAEVSQRDFKVVKITKKLTKKSAPEPFITSTLQQEASKRLNFSAKKTMQIAQALYEGLEIGEYGVTGLVTYIRTDSTRVAEEAKAKAAAYIKNTFGEEYVGTEKKTKAPKGKIQDAHEAIRPTDIEKDPEKIKQYLTPDQYKLYKLIWERFVASQMSDAQYDVTTVDIEAGDYLFRATGSILRFPGFTKIYQVEEEEGEKEEKEKLPALMEGQSLTLLKLEPKQHFTEPPPRYTEATLIKALEEKGIGRPSTYAPILETILKRGYVEKDKKQLKPTELGRIVVDLLKEHFPDIIDVEFTAEMEEKLDQIEEGEKNWIEVLRNFYEPFNETLRQSYEKIEKIILPLEETEEKCPNCGRNLVVRTSRFGKFLACPGYPECKFIKPFVQKTGATCPRCGGEIIVKKSKKGRVFYGCSNYPSCDFVSWDLPSSKKCPNCQSVMVEKRPKKKPPYLLCTNPDCKHTEPLEEVQ
(1634) Reverse gyrase [Thermoanaerobacter tengcongensis MB4]
6
MALATGAKYYHSCINCGGINTDTRNEKGLPCEVCLPFEDGDVLKGLKLNNSLKGYEKYWNLNQQYKEFEEFFFSKINKKPTGYQRFWAKRLLLSKSFTLVAPTGVGKTTFGLISALWIAKKGGKVALVFPTVSLVEQAAKRLIEFSKEDEDVNILFYTSSLKKKEREKFEKNFSEGNYDILVISSQFISKRKEQLSQKVFDLVFVDDVDAVLKSSKNIDTLLNMIGISQKAIDSTLDNLKKGNNSDKIQIEEKAPKGRLIVSSATAKPKGIKPLLFRELLGFEIGRFTTSARNITNVRIKEKSLEKLLYIINLLKDGILLFVPTEEEGKEIANYLEEHGVKLGKTWEDFEKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFSTKLENAPRFILERNFQDYLENNPKLKAYFKDLQRLSTEKLRKSVEKYISPETWEKLIQKNFPTTKFDKEKNLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFEEDDSLFELLKARLLYLTEEEWTEEGEIEHLVKEAEETRKAISTDSSSKDMKSRMIIVESPTKAQTISKFLEKSSTRRYGSLMVHESITQEGILLLTASKGHLYDLETKTGLHGVEINDGRFIPYYNSIKRCSSCGAQFTDELPRCPYCNSDKIDDKKKILEALRDIAMEVDEVIIATDPDVEGEKIGWDISQYIKPVNKNVQRIEMHEITKFGFDKAIRNRRNCDVNLVKSQIVRRIEDRWVGFELSLRLQKNFQNSNLSAGRVQSTVLGWILEKEIEHSKSKKTVTQFTLDNGFKFEVDGKIDVDEVEVEIVEEKEQALSPLPPFNTPSLLTAASQQFKLPVQQIMEILQTLFELGFITYHRTDSTRISSTGQKIARSYLEKIGKITLLSEREWGKEGAHEAIRPVKPISPEELSEFITEKIAAYLSPMHIKVYSLIFNRFMASQMTSPVVINQKILIKNGSFQVEREVPVKLQEEGWNIFNPITVYTPFEEKKYSVVSKRTYTTHTVPLFTQASLIEEMQKRNIGRPSTYAKIVDILFKRKYIIEDVYKRLRTTALGRKVYSYLSERYMNYINEETTRQLEKLMESVETGEKDYQSVLKNLYEELNEILIKN
(1490) DNA topoisomerase 1 [Thermoanaerobacter tengcongensis MB4]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASQGHVRDLPKSQLGVDIENNFAPKYITIRGKGEIIEKLKKEAKDAEKIFLATDPDREGEAISWHIAQLLDLDIDKPCRIEFHEITKNAVQAAIKNPRKIDLNLVNAQQARRILDRLVGYKISPILWKKIKRGLSAGRVQSVAARLVCDREREIEAFVPEEYWNITAVLFDEKTSSKFEAKFYGREEEKIELKNREEVDKIINSLSEEYVVYKVKTGTKKRNPPPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGIEIKGEGSVGLVTYIRTDSTRVAKEAKEEAYRYITEKFGKEYANPDAEYSSKKANVQDAHEAIRPTSVFREPEIIKDSLTPDQYKLYKLIWDRFIASQMMPAIYDTVAMDIKNNGYIFKASGSSVKFLGFMTVYVEGSDFQEEEEEKTLPVLKEGTKVRLEELKPTQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTIATLLERGYVVKDKKVLKPTELGFIVTDALKEFFSEIVDVGFTAEMEEQLDKIEEGKVEWYEVVGDFYRDFYKTLKVAEEQMEKVELEEEVEVTDIKCEVCGRPMVVRKGRYGKFLACSGFPECKNTKPLLEKVGVKCPKCGGEIVKRRSKKGRVYYSCENAPQCDFVLWDKPVNEKCPVCGSLMVEKNTKNGIVIKCSNPECGYQKETN
(864) DNA topoisomerase 1 [Caldicellulosiruptor hydrothermalis 108]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQEIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGKEYLPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTPDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVRKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRVIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPKCGSLMFEKGRKGNRKLVCSNENCAYEEKIGEKGE
(1658) Reverse gyrase [Caldicellulosiruptor hydrothermalis 108]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEECLAQEQLNENIFESLKKKGSLKHYQLYWNFQQIYSMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFSALHGKKSALVFPTISLAQQSFERLNQFKSKIQNADAIRILLFNSSMTKSEKEEFEQRFLSQDFEILIVSSQFISKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKNKSNEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFEFFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEYLQTEKLRQLVSKYISYEDYSKIVNKIFSHLKLTDDGKLIIPDVPTYIQGSGRTSRMFGMNLTKGVSILFEEDDTIFESLKSRLMFLLDEEWIDESEVNLESLIMEVEESRKSRNEDFNVNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWIGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSERTFTLLKLENGYSLEIEGEEECERVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISATGQNIARMFLEKVGKKELFLPRSVGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKIEEEGWLEFLPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILQELYNDISVLLNK
(1688) DNA topoisomerase 1 [Thermoanaerobacter pseudethanolicus ATCC 33223]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKGYANPEANYVSKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVEEFYKDFYKTLKIAEEQMEEIEVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPDCDFILWDKPVEEKCPVCGSMLIEKNTKNVHILKCSNPGCDYQKEVK
(1077) DNA topoisomerase 1 [Clostridium sticklandii DSM 519]
1
MGKNLVIVESPAKAKTIGKFLGKNYTVKASVGHIRDLPKSKLGVDVENDFEPQYITIRGKGSVVNELKKQAKKSDKVYLATDPDREGEAISWHLAYLLGLNEEEPIRIEFNEITKDAIKKAIKHPRKIDRPLVDAQQARRVVDRLVGYKISPILWAKIRKGLSAGRVQSVTTKLICDRENEINAFEPEEYWSIDAITQIDKKNKVDFKFYGDEKGKIELHSKDEVDLILKSIKNKDLVVKAVEKKERKRSAPKPFTTSSLQQEASGKLSFTTKKTMIVAQQLYEGVDIKGKGSLGLITYIRTDSFRISDEAQENAKNYINDKYGKDYFKKYQNNSKSKKKIQDAHECIRPSYVDLAPEDIEDSLSKEQFKLYKLIWERFIATMMADAIYDSQNISASIDKYIFKTNGSKLKFDGFMKVYSFSSQEETILPDMKEASVFPVKKIDPKQHFTQPPARYSEASLVKTLEELGIGRPSTYAPTISTILQRDYVEKKSNSLIPTELGFIVTEIMSENFKEIVDYTFTADMENNLDKIEDGEIEWQNIVKDFYSPLEESIEKAVENIEKVILEEKTDEICDICGSEMVIKFGRFGKFIACKNYPECKGTKPILERIGIKCPECSDGDVIIRKTKKGRIFYGCSSFPKCRFVSWDRPNGEKCPKCDSFLVLSKTKTTEKIKCSNKECDYEK
(245) DNA topoisomerase [Clostridium sticklandii DSM 519]
3
MSYPEKYDIKYKAWRLHDLPFLPEEYKYEIIANVQKQFDIIKEQMNRDDVTTIYVCTDSGREGEYIYRLVDMMVDAKSKEKKRVWIDSQTEDEIKKGVKNAKPLEAYDNLADSAFLRAKEDYLMGINFSRLLTLCYGRTLAKKLEKDHIVIAVGRVMTCVLGMIVNREREIRDFVKLPYYKIQALFEFEGSIDYDAEWKAVEGSKYHLSNQIYKEVGFTDKALAETFVNELKTSKEKPVIEDVKKKKETKNPPLLYNLAELQNELSKKLKQSPDQTLKIAQNLYEKKLITYPRTDARVLSTAVCKEILSNLKGLTQLDKVASLDEKDKTLPEYALEVINSNKHKGLEKTKYVNDKAITDHYAIIPTGQGLSTYNKLPGIEKEVYILIVRRFLAIFFPPAIYNQLSITTKLEDERFFSTSKVCTSEGFQVILNDEKKEDDSKQDKAEILKKLKKGQTVLVKELDIKESETTPPKRYNSGSIILAMENAGKLIEDDELREQIKGSGIGTSATRAEILSKLEKIDYISLNKKTQILTPTTLGESIYDVVAGSIPSLLRPELTASWEKGLSMIASGDIKNDEYMKKLESYIQKNTSRVLTLTKNTNVKNKASEIDKTPLGSCPLCKDGKIKENSKAYFCTNWKQSCNFTLWKNSLPELKEDISRDLVKELLASDKNSIKVHTSENKDIHIKFKESGNGELEITKSH
(1659) DNA topoisomerase 1 [Desulfotomaculum reducens MI-1]
1
MSKTLVIVESPAKAKSIGKYLGKNYTVKASMGHVRDLPKSQFGVDVENAFSPKYITIRGKGDILKELRSAVKKVDHVLLASDPDREGEAIAWHLTKLLEIDEETPCRIEFNEITKNAIQAAVKQPRRIDVDRVNAQQARRILDRLVGYNLSPLLWRKVKKGLSAGRVQSVAVRLICDREEEIQAFIPEEYWTLTGKFLKSAKSPFEAKLHKHKNKKIVIPNQETMDKILAELKGAAYVVSNVTRKERLRNPAPPFTTSSLQQEASRKLNFTSRKTMVVAQQLYEGIDLGKEGPVGLVTYIRTDSTRVSETAIEETRSFIMERFGPAYVPKQPRQVVAKGKVQDAHEAIRPTSVNRDPDSIKQYLTNDQFKLYKLIWSRFLASQMASAVIDTTSMDISAGDYLFRATGSIIKFPGFMQVYIEGNDDGHKEEESVLPELAKGDKVQAKDLTPKQHFTQPPPRYTDATLVKVLEEKGIGRPSTYAPIVETIQRRGYVVRENKQFYPTELGVIVVDLLKNHFPEIINVEFTADMEKKLDQIAEGEQQWAGVLRDFYEPFSQTLETAEEAIGKVQVADEVSEEICEQCGRNMVIKLGRYGKFLACPGFPDCRNTKPLLEPTGVGCPKCEGEMVLRRSKKGRKFYGCSRYPECEFVTWDMPTKEKCTQCGEMMVEKKSRGKEKVLQCVNEHCPSKGEKAASNINGNKKKTVKNNKK
(349) DNA topoisomerase [Desulfotomaculum reducens MI-1]
7
MKTLVITEKPSVGKDIASVLGRFESKDGYLENEKYIVSWAFGHLVELADPSVYDPVFKKWDLATLPIIPDSFKLVEIAGSSAKQLRTLKKLLNSAEVSQVVNGCDAGREGESIFRRIYHFCGCRKPIKRLWLSETTPAAVKAAFKALREGQEYNNLAAAAEARGQADWLVGLNGTRAFTVRHGTVLSVGRVQTPTLNLIVSREREINNFVPVPYWEVWGTFQTDNGMYKGKWFREKEDRLPNREAALNLTTKLSSEAKGQVISLEQKEAKELPSFLFNLNDLQKEGNRRYGFTAQQVLDIAQSLYEKHKLLTYPRTDSRHLSNAMISTLPERLATLKNAPKYAELIPDTLPGLSKRYVDDGKITDHHAIIPTAVDPSKAQLSDQEKKIYDLVVRRFLSIFYPEARYAVTEVFTETAGELFKSRGRVELAAGWKMVWRGSDQETAEEGNGDDPEDQALPPLTQGKSVDVSKVEILEKQTKPPKRFTEATILAAMESAGKFVEDKEMAEVLKQTGGIGTPATRAAIIERLIKVGYVARDKKSLVPTAKGQILIDLVPKQLKSVELTASWEDGLRRVEEGQQNAALWIQDIQAYTRELVVLARNQEVSQGVGTARDTLGKCPVCGRDVVETAKSYGCSGYKEGCKFAIWKEINSKKISAKQAETLLTKGKTGLIKGFKSKAGKTFDALLVLGEDGKITFGFANAVNDQPGSTGNTALGKCPLCGKDVVENSRSYGCSGYKDGCKFVIWREIAKKKITQTQAIELLAKGKTGIIKGFKGQKGSFDAALTIINGEIKFAFAERM
(1707) DNA topoisomerase 3 [Desulfotomaculum reducens MI-1]
2
MHKSLVLAEKPSVARDIARVLNCYKKGNGYLEGDKYIVTWALGHLVTLADPEVYDEKYKSWRLEDLPMLPSPLKLVVIRQSSKQFQIVREQMNRKDLREIIIATDAGREGELVARWIIEKARVVKPLKRLWISSVTDKAIQDGFKKLRDGKEYQNLYAAAVARAEADWFVGINASRALTCKFNAQLSCGRVQTPTLAIIAKREEEIRNFRPKTFYGITVVTDQLKLTWQDRQSKDIKTFHKEHCDQVLSLLNQKTAEVIEVEKTAKKSYSPQLYDLTELQRDANKFFGYSARETLSIMQRLYEHYKVLTYPRTDSRYLSSDMVDTLAERLKACSDQPYTKLAYKILKNPIKPSKSFVDDNKVSDHHAIIPTEQPVTVSTFSDKERKIYDLVVRRFLAVLYPPFAYEQTTIKAKMGEELFIARGKVVIAQGWKEVYQHDLEEEEPKDSLSEQTLPVIKRGDCLKVRSLTQTKGETKPPEPFTEGTLLSAMENPAKYMSQDNKELIKTLDKTGGLGTVATRADIIEKLFNSFLIEKKGKHIAITSKGKQLLELVPEGLRSPALTARWEKELEFIAKGILNKSQFINEIKKYATTVVHEIKESENRFRHDNLTGTKCPECGKRMLEVNGKKGKMLVCQDRECGYRKGLSKVTNARCPECHKRLELHGEGEGQIFVCKCGYREKLTTFHERRKNEKGSNISKKDVNKYLRNQETKDDFLNNPLAEALAKLKLKS
(1794) DNA topoisomerase [Desulfotomaculum reducens MI-1]
7
MKQLILAEKPSVGRDIVNAIGGHFEKRDGYYENSQYIISWAIGHLVELCEPEDYQPNLKKWTLSALPIIPECFKLKPNPKTIKQYKVVKQLLNRPDVELIAGTDAGREGELILRYIMRLSGYSRPFKRLWLSETTPESIRKGLANPLPGQAKDLLAAAAECRSHADWLIGINATRAFTKKHGDLFSIGRVQTPTLGLIVAREKEIKTFIPAHYWELYADFVTTDGQVYRGKWFKNKNKNRFNQEADGISIKNKIVGQDGSVIKVEEKAVSEPPPTLFNLNDLQKEANKKFGFTASQTLEIAQALYEKHKLLSYPRTEFKHLTNELAKTIPSRLSALGSVSGYSKFVAYAQSAPKPGKRFIDDAKVGDHHALIPTNVKPTAALSPNEAKIYNMVARRFLAMFFPAAEYKQTKIMTSVSDETFLTSGKIELSPGWKEVIPPLKGENKEKSDEEVLLPPLTKGENVAVTKAKLQQKKTEPPKRYTEGTLLAVMEGAGKFVDDKALKDAMKGHGLGTSATRAAIIERLIKVGYVERKSKTLIPTQKGETLISLVPEVVSSPQMTGEWEKALADIEAGQVNPKRFMSEIISLTKKIVNLAKEQKTNGYMPESTKEVVGKCPLCGREVVEYAKKFGCGGFREGCAFSFGKQILKKKITVKQAKQLLTNGKVLIKGFTSSKTGKKFDAALVLKDGKVSFDFS
(593) DNA topoisomerase type IA central domain protein [Ruminococcus albus 7 = DSM 20455]
3
MKKLIICEKPSLAKNVRDAIAHRENVQRVGNKDLYYYESSSYVITFCFGHLLTLGEPEKYIAEGETAVLPIIPANFRLFPNDKDCARQYSLIKKLMDMPEIDGIIHCGDADREGEIIVRNVLRVARNTKPVYRLWLPEQTESTILKALSSLENDSKYDDLANAGYARTFVDWLFGYNLSRYLMQKANVRKGWGVGRVIIPIVDTVYQRELEIRNFVSTPYFQLHGETEKDGIKVTITDKEKFDTQEQAQLRLTELSSGVYRVGSIDTKKAVVTPPKMFSLDTLQGKLSKDLGMTLDKSMPIIQSLYDKKFITYPRADTEYFAEEEKADVFAVADKMNAVYSLDLEHKVSKKIFDSSKVESHSAIRPTLNFPTNESGLSDDEQKVYNTIVKRFCAVFAPPCTVNRTVIVFTDGTHEFKIKGDTPLTPGFRRYEPPKKTNDNDEDNKMLPSFSPGELVSFSWVIDNKMTKAPPRYTIDSLNAYLKAPFAKSSSAQDNDDSPADDSELYEAVKKGMEIGTVATRTGLITKCVKTYKYLDIKQGKYYCTEKGEAFIGYLHQLNIDLFTERNIEFNMMIKSVELGKETMQHSIDKTADELRRIIAQDVTVCSAQKFTDSNSLGKCPFCGSDVLDGTKNFYCSAYKSGCKFVIFKNTYCHFSFVKDGKEINYTKPMSLTKSNCKALLSSGSTTVSIEEKNGKGKYKIGVTFKPDNKHEFVGIERIREKKKEG
(436) DNA topoisomerase 1 [Ruminococcus albus 7 = DSM 20455]
1
MSDLVIVESPHKAKTVKRYLSGDYEVVASMGHLRDLPKSKLGVDIENDFEPQYINIKDKESLIKEIKKKAKASDHVYLAGDPDREGEAISWHLAQLLGLDMNDKNRVTFNEITKSGIDAGMSNPRTIDLNLVNAQQARRILDRIVGYKLSPFLWRKIRRGLSAGRVQSVAVKMICDRENEIRAFVSQEYWSIDAMFLAEGSKKAFASKVDTVDGAKPDLKSKADADAVLKRLEGAEFIVDKVKKSVRKKNPAAPFTTSTLQQEASRRLGFQGRRTMKAAQELYEGLDIKDMGPTGLITYMRTDSLRISDEARAAAYDFIKEKYGDAYIPEKPRVYKTKGSAQDAHEAIRPTNPAITPELVKASGVTNDQYKLYKLIWERFIASQMANCTMDTMSVDIAANGVMFKATGYSVKFDGFTVLYEESKDEEEEKKNVLPPLAKGDKLTPKEILGNQHFTQPPPRYTEATLVKAFEETGIGRPSTYVTTVTTIINRNYVERDGKQLKPTSLGEVTNELMSEHFDKIVDVKFTANMEKSLDDIESGKIGWVKTLQKFYKEFDSELGTAEKEMEGKRVKVPDEATDEICEVCGKPMVIKIGRFGKFMACSGFPDCKNTKRIVQETGGDCPFCGKRVLLKKSKKGKKYYGCENNPECSFMTWDIPTEEKCPRCGSTLFQKGGKNGILICHKQDCGYQRSLSGESAGSEE
(861) DNA topoisomerase 1 [Clostridium cellulovorans 743B]
1
MGTNLVIVESPAKAKTIRKYLGKNYVVEASMGHVRDLPKSQTGVDVENNYEPKYITIRGKGELLDKLRKQAKKSEKIYLATDPDREGEAISWHLSKVLKLSETEKCRIEFNEITKTAIKAAIKSPREINMNLVDAQQARRVLDRLVGYGISPILWRKVKWGLSAGRVQSATLRMICERDKKIKEFIPKEYWTIEGIFNSTDDTKNSKEKLNLKLHNFKNEKIEIDTKEKADEILNIIKSGNYTVSKVKKTERIKNPLPPFITSTLQQDAYRKLNFTTKRTMSIAQQLYEGIEIKGKGSVALITYMRTDSVRISDEAQKSALEFINTSYGTEYVPSEPRIYKGKKNIQDAHEAIRPTYIDITPDKIKGDVKDEIYKLYKLIWERFVASQMKSCVLDTVSVTVDNSGYNFKANGSTVKFDGFMKIYSYGTEGDESLTTIPKVQEGEMLSCIQIDGLQHFTEPPARFSEASLVKTLEENGIGRPSTYAPTIATLLSRKYIEREKKTLVPTELGIIVDNIMCEFFNQIVDEEFTANMEERLDDIELGDSDWRKIVNEFFTPVKAEIEKAEIELAKITIEDEVTDIQCEKCGRNMVIKHGKFGDFLACPGYPECENTKPIVEEIDTPCPKCGSKIVVKKSKKGRKFFGCSTYPNCDYVSWYEPSSKKCNQCGSIMLKKYNKTNGNYLECSNSDCKSKEIIQEETE
(274) DNA topoisomerase type IA central domain protein [Clostridium cellulovorans 743B]
3
MSKVIIAEKPSVAKNIAEALKSNIRKDGYLEGNGYYITWAFGHLLQLYDAKDYDEKMAKWKMDNFPFIPKAFKYKVKNDSKKKDKPDAGAKKQLKIIEELINRNDVDMVISACDYDREGQIIGDIITGYLKVKKPVYRLLQNEWTADEVIKGMEKIKPNTEMKSLRDAGISRQWADWTIGINLTSVATLKYQRGKGNPLNIGRVLLPTLKIIYDRDKEIANFVPDNYFKLNATFKTSDNIEYEGAYIEKEQEKEQEKFKEREKLDEISKKMKGCTGVIVDKQTEKKKEYPPYLFNLSNLQGYITSKYKGWTSDKVLKVAQGLYEKKYITYPRTASVVLEESLADRAAKVLNTLKKSLPFQEEVKFIKNKRIFDNSKVESHSAIIPTYLEPKTLSGDEEKVYSAIKNRFIAQFMPIAESEETKIFTRIKNFDLDGIFISKGKVQIVEGWKKVEKIESKDTILPFVNINDEVDTIKTKVSAHSTKPPKRHTEKTLLRVMETCGKKFDEEQSDQMMDAILSGFSIGTPATRAETIKKLKDIGYIYTEGKNLICSELGVKLVETFPIQELFDLEYTGRLEKTLADMEKGKVEKEDFLKLIFDFTTNAINQIKGDKENVINQYEGELVKGESLGKCPCCGNDVIEGKIGFGCSNWRSGCKYVVWKEDKFLMSMGKKITKDMVMSLLADGKVAIKGLKSRKGNIFDASLSYEKNKDNDYFSWKMEFLNSQESKNRT
(756) DNA topoisomerase 3 [Clostridium cellulovorans 743B]
2
MSKTVVLAEKPSVGREIARVLKCTKSGNGYIEGPKYIVTWALGHLVTLADPEVYDDKYKSWRLEDLPMLPKPLKLVTIKQSGKQFNAVKEQLNRKDVDEIVIATDAGREGELVARWIIEKARVKKPMKRLWISSQTDKAILDGFRNLKPSAQYENLYRAAQCRAEADWVVGLNVTRALTCKYNAQLTAGRVQSATLAMIVSREEEIRTFVPKDYFVINAKAKGFNLQYRDKNNNSNIFEVDKVNKVLSAVRGKEANIVEVTESYKKQYSPALYDLTELQRDANRIYGYSAKQTLSIMQRLYENYKVLTYPRTDSRYLSTDIVATLPDRLRAIAVGSYSAVANEILKGKITGHKGFVDNSKVSDHHAIIPTEEKGKLALLSSEERHIYDLVVKRFLAVMLPPYEYLQTTIKADINGETFVAKGNVIKAKGWKKVYDKEATLAEDEDDKDSQTLPVVKKGDKLNVMSIDSEKHKTKPPARFNEGTLLSAMEKPQKYVSLDKVHAKTLGETGGIGTVATRADIIEKLFNMFYIEKNGKDIIPTSKGKQVIDLVPSELKSPLLTAEWELELERISKGQKDSRGFIEAMRKYAAELVDDVKGSSDKFKHDNLTGKKCPDCGKYMLEVKGKQGRMLVCQDRECGHRENLARITNARCPECKKKLELRGQGEGKIYVCPGSNCNFREKASQFEKRFDSKSDKLNKREVAKIMNKLNQEKEDPMDSPFADLMNMFKDKK
(979) DNA topoisomerase 1 [Clostridium cf. saccharolyticum K10]
1
MAKNLVIVESPAKVKTIKKFLGSNYEVDASNGHVRDMPKSQMGIDIEHGYEPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLSKALKLEDCKDKKVYRITFNEITKNAVKAALKTPRAIDMNLVDAQQARRVLDRMIGYRISPLLWAKVKRGLSAGRVQSVALRMICDREEEISSFIPEEYWNLEAKLKAKGSKKKLTAKFYGTREGRMAIHKKEELEAVTAALEGAQYTVDEVKTGERVKKAPIPFTTSTLQQEASKTLNFSTQKTMRLAQQLYEGVDIEGKGTIGLITYLRTDSTRVAEEADKTAREFIEEKYGKQYVSTEEAVKKGGAKIQDAHEAIRPTDISLTPAVVKESLARDLFRLYQLIWKRFAASRMQAAVYETTSVRVAAGYAGGEYLFTLSASKLKFDGFMSVYVQEDEKEESTVLSEKLEKGDVLACEALESSQHFTQPPAHYTEASLVKALEEQGIGRPSTYAPTITTILARRYVVKENKNLYVTELGEVVNRMMKKAFPSIVDTAFTANMEYLLDRIGDGTVQWKTVIENFYPDLEEAVKEAEKKLEAVKIADEVSDVPCDLCGRMMVIKYGPHGKFLACPGFPECRNTKPYLEKIGVACPKCGKEIVIRKTKKGRKYYGCENNPECDFMSWQKPSAERCPECGGLMVEKGNKLLCTNKECGYVKTKENRQQQE
(633) DNA topoisomerase [Clostridium cf. saccharolyticum K10]
7
MKLVIAEKPSVGAAIAAVLGANEKRSGYFEGSGYLVSWCIGHLISLADAATYNEQYRKWKYDDLPIVPQDWQFTVASGKEQQFSVLKDLMHRSDVSEIVNACDSGREGELIFRFVYEQANCKKPFSRLWISSMEESAIREGFSNLKDGRSYDDLYQSALCRAKADWLVGINATRLFSILYHKTLNVGRVQTPTLTMLVNRDYAISSFKKEKYHVVRLNAGGVSALSERLNDEAAAQQMKAACEKSQAVCTSLKKEKKTVSPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYPRTDSKYITSDMQDSTKELITGLCSLLPFMRDVKLQADLTRVCDNSKVTDHHAILPTAEFLKAGFSSLADSETKLMTLVCAKLLCAAAAPYEYEAVTAAISCGGYTFTAKGKTTLCEGWCEIEKLSRAASEEQDEDAEPETVLPPLAEGQTFDNPAAEISERYTQPPKAYTEDTLLSAMENAGKEETPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLAAILPEVLTSPQLTAEWETRLTGIAKGSDSPDDFMRSIEEMTAGLVKTYSAISEDKAKLFTPQREAIGTCPRCGAAVYEGKKNYYCSDRACSFVMWKNDLFFQQRKKTFTKAIAAALLKDRKVKIKGMYSTKTGKTFDGVVLLADTGGKYVNFRVEQNRK
(1740) DNA topoisomerase III, bacteria and conjugative plasmid [Clostridium cf. saccharolyticum K10]
7
MRLVIAEKPSVAKSLATVLGAATRKDGYLEGNGWLVSWCLGHLAGLADAATYNPDYAKWRYDDLPILPETWRFTIAKDKRDQFDVLRTLLRREDVTEVVNACDAGREGELIFRTVYCLAGCQKPMKRLWISSMEDSAIREGFAHLRPGADYDGLHQAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDAFKPVPFYTVALDLPGFTAASARMDKKADAEQLKNACQSGTVTVKQVARRDKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQNLYEKKLCTYPRTDSRYLTSDMAEGLPVLVNLVANAMPFRKGIAISCDAAAVINDKKVTDHHAVIPTRNIREADLSALPVGERAILELVALRLLCAVAHPYIYDETSVTVECAGAEFTAKGRTVKQPGWRALDAAYRASMKNAEPDKETEDKALPELAEGQELPVAGAAVKEGKTTPPKHFTEDTLLSAMETAGAKDMPEDAERKGLGTPATRAGILEKLVSTGFLERKKSKKTVQLLPSHDAISLITVLPEQLQSPLLTAEWEYRLGEIERGELAPEDFMAEITAMLKELVGTYQVIKGSEYLFAPPREVVGKCPRCGGEIAEMQKGFFCQDKSCKFAIWKNSKWWAAKRKQPTKAIVAALLKDGRARVTGLYSEKSGKTYDATVVLEDTGQYVNFKLEFDRQKGGGK
(871) DNA topoisomerase [Clostridium cf. saccharolyticum K10]
3
MAKALYIAEKPSVAQEFANALKISGRRADGYIESETAVVTWCVGHLVTMSYPEEYDIKYKRWSLETLPFLPAEFKYQVIDGVKKQFQTVSTLLNRSDIDTIYVCTDSGREGEYIYRLVAQMAGVHGKKEKRVWIDSQTEEEILRGIREAKELKEYDNLAASAYLRAKEDYLMGINFSRALTLKYGPSISSFLRSKWTVVSVGRVMTCVLGMVVRREREIRNFVKTPFYRVIGTFTRESMKISAEWRAVQGSRYFQSPFLYRENGFKEREKAEELIAWLSAEGPVTGTVFSVEKKKETKNPPLLYNLAELQNDCSKMFKISPDQTLKIVQELYERKLVTYPRTDARVLSTAVAKEIGKNLSGLKGFSPCASFAAEVLQGTAWKTIAKTRYVNDKQITDHYAIIPTGQTGAVRNLPSLNAKVYELIVRRFLSIFYPPAVYRKYSLEIAAKTEHFFANFKILKEPGYLKVADVSGIRKKDENAEGTKDTAGAAGESSGEQSAGDSRQEETVIGDEAFAAMLEKLKKGMTLDLSGLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLMSISYLSLNPKTQVITPTLLGELIYEVVNASIRQLLNPELTASWEKGLTYVAEGSITEKEYMEKLERFVAGRTYGAVHTANQAGLRRQFELAAASYKGAEKLPGKGAASAEKAGKNVKNSRKKSAKTGGTINEKN
(268) DNA topoisomerase 3 [Clostridium cf. saccharolyticum K10]
2
MKSLVIAEKPSVGKDIARVLGCRKSADGCLEGDKYIVTWAFGHLVELAAPEEYDKKYKDWNMADLPMMPEPFKLEVIGKTAKQFGVVKRQLFRNDVKDIVIATDAGREGELVARFILMKAGCRKPLKRLWISSVTDRAIKEGFSRLRDGREYNHLRDAAMCRAEADWLVGLNATRALTCKYNAQLSCGRVQTPTLAIIAKREEEIRNFRPKAYWGLTARTSKPALTLTWQDKKSGGMRSFDRDRMEGLQKSLRDQQVRITKVKKTPKKTMAPLLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDVADTIHDRLAACGTGPYRKLAGKLSKNVWTKKASFINDGKVTDHHAIIPTEQFVQLQNMTSEERKIYDLVVRRFLAVLYPAAEYDETVITAEIGGEIFTARGKVMRTPGWREVYESADESGLSGTGGYLDEEDGDEDGEGPQNEERVKAQTLPDLREGDVTGPAGISLTEGKTKPPAPFNEAALLSAMENPVRYMESGDRAMAKTLGETGGLGTVATRADIIEKLFSGFMLEKKGKDICLTSKAKQLLRLVPEDLRKPELTAQWEMRLSKIAEGEMKRDAFMEDIRTYTKDIVEEIKGGEGTFRHDNLTNTKCPRCGKRMLSVKGKNSQMLVCQDRECGYRETISRTSNARCPKCHKKMELRGKGENQMFSCVCGYKEKLSNFKERRQREGAGVTKRDVARYLNQQKKEEKMVNNPFADALKKMQEQDV
(395) DNA topoisomerase [Heliobacterium modesticaldum Ice1]
7
MKTLIIAEKPSAAEAIAEAVAGTYQKKRGYLESPDFYITWAVGHLVQLAEPEDYRSSLKRWRFGDLPIIPDFQLRPVKKTEGQLKTIAGLAKKSRALINACDAAREGELIFRYIVAYLRLEEMPAWRLWTASLTAEAIRAAMADLKPLDRYDNLFKSARCRSEGDWLIGINATRAFTTRFGELLTLGRVQTPVLAMICENRRRRDAFVPETYWEVWARFRGEGCDYRGLWLREKGEAHRLNEKGKAEAIAAAVDGRNGEVRQVDEKESRELPPRLYDLTTLQRECNRLFGFSANKTLKIAQELYDSKFITYPRTNSRFVDKHGLALLRRVVSGLASHPVYGPFVAQGNPQLVHERNRNICRPEAVEDHHALLPTTLVPTGLVGDKWKVYDRIVRRVLAHYYLPARYRERVVLTVVPFERITGKATDLPVGDLGMATAVLDSAHSKEADDLGGAVFRSAEKTIIDPGWKVVDGGWTPPKEQERFPERAGLAVRCAGAEVLEKQTEPPKAYTEGSLLAAMETAGKQLDDEELREIMKDAGLGTPATRAATIERLKEVGYIELQGRQIEPTPKGMALISLVEKSEIPLLLSAEMTGRWEKFLNEIARGNAQPLEFNRRVSDLAVYLVKQLEAAEKSWYDKSACARRLGTCPRCGGAIVENRKAYVCANWKVEQCPVTIWKTFRGKGITEKTALALLEKGRSPRLRFYTKEKKPYPAVIVFDAQTGVMNLEFSSAATRSTKSARPKKATPAAEPVEPAERDRSTNTAKTLQPSNSGNQTASMKKA
(119) DNA topoisomerase 1 [Heliobacterium modesticaldum Ice1]
1
MSNKVLVIVESPAKAKTIGKFLGRRYQVKASMGHVRDLPKSQFGVDVDGGFNPKYITIRGKGELLKELRTAAKKSDQILLGPDPDREGEAIAWHLAQVLGVDEHTPCRIEFNEITKSAIQKAVKKPRPIDTNRVEAQQARRILDRLVGYNLSPLLWRKIRKGLSAGRVQSVAVRLISDREEEINDFTPDEYWSLTAELKAVKGNLQARLVRQDENKLEIKSREEMDRILGELAGQVFAVSEVKRKEKRRNPSPPFTTSSLQQEAYRKLGFTARKTMMIAQQLYEGLDLGKEGTVGLVTYIRTDSVRVSDGAVEEVRQHIQTRFGSDYLPAEPRVYENKGKIQNAHEAIRPTSVTREPETLKAVVTNDQYKLYKLIYERFISSQMSSAIMDTTTIEIKAGAFGFRASGAVLKFPGFMKVYIEGRDDDSKEEEGLLPEVSVDEKLDLQKLEPKQHFTQPPPRYSEATLVRALEERGIGRPSTYAPIIETIVARGYVVREDKQFYLTELGEVVVDLLKEHFPDIIDVEFTADMEAKLDAIEEGAADWRRILRDFYEPFRETLEEAEEKIGEIEIADEVTDQRCEVCGANLVIKQGRFGRFLACPRFPECRFTKPLLEEIGVPCPKCDGHVVIRRTKKGRKFFGCANYPECDYVSWERPTNVPCPLCDKPLVQKESKKLGTRRVCITEGCGYEEAVSDGEKGASTGWPVGDPRAQGGPGERRELAEPGVP
(326) DNA topoisomerase [Clostridium novyi NT]
3
MEKSLFITEKPSVAMEFVKLLNIKETKKDGFIESDNAIFTWCVGHMVTMSYPEAYDENLKIWSLKTIPFLPKEFKYELIPSVLKQFNVVKSLMLREDVKTIYVCTDSGREGEYIYRLVDMMVGVEGKDKKRVWIDSQTEEEIKRGIKEAKPLSEYDSLSDSAYLRAKEDYLLGINFSRLLTLIYGKTVSNIIGEDRVVIAVGRVMSCVLGMIVERELQIRNFEKTPFYKINGSIEIEENLGYECEFKAIEKSKYFESPKLYNDGGFKEKKDAEKLIEEIRIESKDNTAIIEKISKKKETKNPPLLFNLAELQNECSKNFKISPDETLNIIQELYEKKMLTYPRTDARVLSTAIAKEINKTISKLLRFKENEKVNNACKNILEKKLYVGLEKTKYVDDKKITDHYAIIPTGEGLESYRSLKPFQRNIYDLVVRRFLAIFYPPAIYSKITVETKIGEEYFFTTEKVCVTRGYLDILEEAQKDEKEKNLDFLNKLKKGTIVKIDELTIKEGKTSPPKRYTSGSIIIAMENAGKLIEDDELREQIKGSGIGTSATRAEILKKLERIEYIKVNNKTQIITSTTKGEVIYRVIRSSMPSLLNPKLTASWEKGLSMVVDREITPEVFMNKLENYINKNISNVVDNNRVINTNYLISGLEENNKKKIDEEKIDDVLGVCPICKKGTIVKNNKGYGCNNWKEGCKFFVAEICGVKIPVGEIKNLIKYGKTNIINGFKSKKGNEFRARLILKDNKVQLSFD
(613) DNA topoisomerase 3 [Clostridium novyi NT]
2
MGKILILAEKPSVGRDIARVLNCKKGGNGFLEGDKYIVTWALGHLVTLADPEAYDNKYKSWNIEDLPMIPKHLKLVVIKKSGKQFNTVKAQMNRKDVGEIVIATDAGREGELVARWIIEKAHIKKPIKRLWISSVTDKAIKDGFKNLKDGREYNNLYKSAIARAEADWLVGINATRALTCKYNAQLSCGRVQTPTIAMIAQREEEIKNFKPKTYYGIEAKSDKLKLVWQDSRSNDIKTFNKDKCENIIKNIKNKDAKVVEVNKVKKKKFSPQLYDLTELQRDANKIFNFSAKETLSIMQRLYENHKVLTYPRTDSRYLTEDVVDTIKDRLKACGVGVYGKYANKLLKGTIKGNKSFVDNTKVSDHHAIIPTEQKFALASLSDNERKIYDLVVKRFFAVLYPPFEYEKTTIKAKIGEENFIAKGKVVLANGWKEVYSNDFEDDMEDELKEQILPSINKGDSIKINSISKTTGETKPPKPFNEATLLSAMENPVKYMSGESKELKKTIGETGGIGTVATRADIIEKLFNTFLIEKRGKDIFITSKGKQLLDLVPEELKSPALTAEWEQKLTAISKGKLNKDKFLSEIKDYSKDTVNEIKNSKEKFKHDNMTRVKCPECGKYMLEVNGKKGKILVCQDRECGYRKGISRISNARCPECHKKLELRGEGEGQIFVCKCGYREKLSAFKERKKKDSGKVSKREVNKYLRQQQKENDEPFNNPFAEAFKKLGLK
(122) DNA topoisomerase 1 [Clostridium novyi NT]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVTASMGHVRDLPKSQLGVDIENNYNPKYITIRGKGELLSSLRKQAKKSDKVFLATDPDREGEAISWHLAEALKIDENEECRIEFNEITKNAIKSAIKNPRRLNLNLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMICDRENEIKEFNPKEYWTIECELKNEKSKKSFTVKLVSKNNEKIEINNEEESNSIIKELKQNKYIVKSIKKSEKHKKPLPPFTTSTFQQDSYKKLNFSTKKSMSVAQQLYEGIDIKGKGTIGLITYMRTDSVRISDEAQKNARQFITENFGQNYVPESIRNFKGKKNIQDAHEAIRPTYIELAPDEIKDNLKPDQFKIYNLIWKRFMASQMADCIMDTMSININNGQYTLRVSGSNIKFDGFKKVYKYEEDEESLKFPVLEENEILQDKKVEGKQHFTQPPARFSEATLVKTLEENGIGRPSTYAPIVSTLLDRKYIEREKKTLTPTELGFIVNNIVSEYFKQIVDVEFTAEMESKLDNIEEGKEKWKDVVNEFYSPLIECINIAEKEIAKIKIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVKELDVPCPVCGGKILLRKSRKGRKFYGCSNYPECNFVSWSEPVKDKCPNCGSYMVKKQSKSKGNYIECSNKECKTKIQQENQNVEK
(518) DNA topoisomerase 1 [Clostridium clariflavum DSM 19732]
1
MADKLVIVESPAKAHTISKFLGKDYKIIASVGHVRDLPKSQMGVDIENNFEPKYITIRGKGDVISKLKKEAKNAKKIYLATDPDREGEAISWHLAYLLNIDSKEKCRVTFNEITKNAVKNAMKEPREINLDLVNAQQARRILDRIVGYKISPILWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTIDAVLQKKDEKGSFNAKFYGKDGKKMELKSEDDVKRILENIKGKPFIVQKIKKGEKKKSPAPPFITSTMQQEAARKLGFSTKKTMIVAQQLYEGIDIKGVGALGLVTYIRTDSTRISDEAQQDVIQFIKEKYGEKYLPTEKRVFKNKNASQDAHECIRPSQVNMDPDSIKDSLTKDQYKLYKLIWSRFVSSQMASAEYDTISTDITIGDYTFKANGQMLKFPGFTVLYQESKDEEGEEKENDIPDLIEGEELKQKKIEPKQHFTQPPPRYTEASLVKTLEEKGIGRPSTYAPIITTILARGYVVKDGKTLMPTELGKIVNDIMKTYFQDIVDVEFTAQLEKKLDDIEEGYKKWVDVMQSFYSPFAKVLEEAEEKIGNVEVPDEVTDEICEKCGRNMVIKMSRFGKFLACPGFPECRNARPILEEAGVKCPKCGGKVYIKKSKKGKKYLGCENNPTCSFMSWDMPSKESCPKCGNFLLKKYLGKKVQLKCSNEECDFIKDGERKKEE
(1087) DNA topoisomerase [Clostridium clariflavum DSM 19732]
7
MGKNLYITEKPSVAASFAAVLGVNISKSDRTRGYAESKDSVVTWCFGHLITLALPDAYNDAYKEWKVEHLPIIPEEYKYVVIDDEGIKKQFETVKSLMLREDIDYIYACTDSGREGEYIFRLVYEHSGTTKPAKRVWISSQTEEAIKEGIKNAKDISHYDSLAQAAYSRAKEDWLFGMNFSRIYTCLYGRHLSALLKESRSSVIAIGRVMTCVLGLVTDREKEIRNFVPKTHYGITANFISMDNKIEYKGKWVPEKSKIIKFADDAQDEERYISKQEAEEVIEKLKGKEGKVKKVEIKSKNEQPPLLFNLAELQSEANKKFKLPVDKTLETAQSLYEKKLITYPRTDCRVLSTDVVGELPKVLNGLYMNPEYKGFVSRIKDFGELKITKSTKRYVDDSKVTDHYALIPTYVTADLNRLSENERKIYNLIVKRFLAIFYPPAVYNTVKVETEIDGEVFVTSSRTLKEAGWKEVYEVSKSKDEEDLTEVPIHLLSKNEGCETKNFELEEKETKPPPRYTAGSLIITMEKAGKFIEDEELREQIKTCGIGTSATRAGIIKKLKDIGYINIDSKTQVVTPTLKGEAIVELVRRTAKELLSPSLTASWEKGLAMIENKETTQEIFEKKLCDYINKTIQKVKKSNSDNSINLIRMFKDVI
(635) DNA topoisomerase [Filifactor alocis ATCC 35896]
7
MEHKLVIAEKPSVAISIAKVIGAKNKKDGYYEGNGYKVSWCVGHLIQMANPDAYDEKYAKWKIDDLPIITKEYKYEVAKATKKQFAVLKKLMNDKEIDTVINACDAGREGEAIFRLVYLQASCKKKMKRLWISSMEDSAIKDGFDNLKDGNVYDNLFESAQARAIADWLVGMNISRLYSCLYKQNYSVGRVQTPTLSMIVKRDDEIANFKKEKYYTVELELDGFTLSTERIDSLEVAEQLKNLLECRIEITDVIQTEKITKPDLPFDLTTLQRECNKHFGYSAKQTLDYAQSLYEKKLITYPRTDSRCLTEDMITSTVNNILGKNDFDTERIRVVFNSKKVTDHHAIIPTVSSMSEDLSSIPESEAKVYRLISNKLHASVGYPLIENTTKIVATFDGFEFTSSGKVIVDEGFTKYLKEYMSKKNEEPVLPEINVGDVLEIKEKEIKEKYTQAPKHFTENTLLKAMEIAGNDGLDKNVEVERKGLGTPATRAGIIENLIYKGFIERDKKNLIATNKGISLITIVADTFKSAETTAKWEMELSDISQGKSSKEEFLNTIEHEIRNELSHYKKE
(1412) DNA topoisomerase 1 [Filifactor alocis ATCC 35896]
1
MAKNLVIVESPAKAKTIEKFLGKKNYTVKASVGHIRDLPKSKLGVDVEQNFEPQYITIRGKGDIVKDLKKEAKKADFVYLATDQDREGEAISWHLAYLLDLDINDNNRITFNEITKDAIKKAIKSPRKIDLDLVDAQQARRIIDRLVGYKISPILWIKVRKGLSAGRVQSVSTRLIVEREEEIRAFTPEEYWTIDATVTGEDKRKAVFKLTEKNNKKIELHSEEETKLVLKDLHKKDMLIDKIDSKEKKRSAPKPFTTSLLQQEAGNKISFSSKRTMSAAQQLYEGVTVKGEGTVGLITYIRTDSQRISEEALASSKKYIEETFGKNYYQKYSSPKKKNSSIQDAHECIRPTSIYRTPESVKDSLTTDQYKLYKLIWERFVAASMSSAIFHTDTVLGSIDDYQFKVSGSTLVFDGFLKVYSYSKAEEQEIPNFVEKQYYKVNKLTDKQHFTQPPARYTEATLIKTLEELGIGRPSTYSPTISTILQREYVKKEKNFLIPTELGEIVTSIMKENFKNIVDVDFTADMEKQLDSVEEGTLPWKSVVEKIYTPLIEDVTVAEENLEKVLLQEKTDEKCPVCNEEMVVKYGRFGKFLACKNYPECTGTKPYLEKIGMPCPDCEDGEVIIRRSKKGRIFYGCSNFPNCSFVSWNRPTGKKCPECQENLVEKVTKKGTQIVCSSKTCSYKEEVKQ
(1631) DNA topoisomerase [Filifactor alocis ATCC 35896]
7
MKLVIAEKPSVALSISKIIGAKNKKDGYYEGNGYRVSWCVGHLIQMANPDSYDEKYAKWKIDDLPIIPSEYQYEVAKATKKQFAVLKKLMNDKAIDTVINACDAGREGEAIFRLVYLQASCKKKMKRLWISSMEDSAIKDGFDKLKDGKDYDNLFESAQARAVADWLVGMNISRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEITNFKKDKYYTVELSMNGFILSTERIDDEVAAEQLINLVGDKIEITDVIQKEKITKPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYPRTDSRCLTEDMITSTVNNILGKNDFDTGRIKTVFNSKKVTDHHAIIPTVSSLSEDLSGIPESEAKVYRLISNKLHASVGYPLVENTTKIVAEFDGFQFTSTGKVIKDEGFTKYLKEYKFNKNEDLELPDVSIGDVIIIENKEIKEKYTKPPKHFTEDTLLKAMELAGNDALEKGVEVEREGLGTPATRAGIIENLIYKEFIERDKKNLIATPKGKSLIEIVVDNFKSAEMTAQWEMELSEIAQGKSSKKEFLEKIEEQIKHTVEEHQKNE
(1372) DNA topoisomerase 1 [Natranaerobius thermophilus JW/NM-WN-LF]
1
MASNLVIVESPAKAQTIKRYLGKQYKVKASMGHLIDLPKSQMGIEINEVFKPKYITIRGKGKILSELKKEAKKADRVYLAGDPDREGEAICWHLGRALGIDEDEHCRVEFNEITKDAIKAAFKEPRKIAYNLVNAQQARRVLDRLVGYNISPILWKKVRKGLSAGRVQSVAVRLICDREQEIKEFVPEEYWTLIAQFSKDGEKFEGKLQEVDGKKAEIPNEERMNEILSKLENATYKVHKVEKKERKRNPNPPFITSTLQQDAYRRLGFSARRTMRTAQQLYEGIKVSGEGHVGLITYLRTDSTRISQSALTAAKEYILEEYGEDYYPGKPRTFKGGKGSQDAHECIRPTRTDLSPEKIKSALSNDQFKLYKLIWNRFIASQMAPAKYDTVAADIYAAGTMKFRARGSQLKFPGFLALGHEDQDKDEILPELKQDDLLDLEELQPNQHFTQPPPRYSEASLVKTLEKEGIGRPSTYAPIIETIQTKGYVIQEEKRLYPTQLGEIVVEQLKEFFPDVLDVDFTAEVEQGLDKIEDGEKDWQEFLYEFYEPFEKQVKTAEEEMKKIELEEEQTDVECEKCGSYMVVKHGRYGKFLACPNFPDCKNTKSFVKELNVECPKCQGTIVERKSKKGRKFLGCNNYPDCDFITWYKPVEGKKCPKCESFLVQRGKKNKYYQCSHPDCDYSADAVEEQEEKQS
(1210) DNA topoisomerase 1 [Roseburia intestinalis M50/1]
1
MAKYLVIVESPAKVKTIKKFLGKNYEVVASNGHVRDLPKSQMGIDIENDFEPKYITIRGKGDILAKLRKEAKKADKVYLATDPDREGEAISWHLSQALKLDDKNAQRITFNEITQNAVKASLKEPRKIDMNLVDAQQTRRILDRLVGYEISPLLWAKVKRGLSAGRVQSVALRIICDREDEINAFIPEEYWTLDAELSVKGERKTLLAKFYGDENGKLTISSKEQADRIMAEMQKEEFHVLEVKKGERVKKAPLPFTTSTLQQEASKALNFPISKTMRIAQQLYEGVDVKGQGTVGLITYLRTDSVRISEEADAQAREYIAGNYGENYIAGEKTTKKNGAKIQDAHEAIRPSDINRTPVMVKESLSRDQFRLYQLIWKRFTASRMAQAVYETTNVKIGAGEYRFTVSASKIAFDGFMSVYTSDDDEKAENNVLVGSIDENTVLNLKEFDEKQHFTQPPAHYTEASLVKTLEELGIGRPSTYSPTITTLLGRRYIVKEAKNLYVTELGEVVNQIMKESFPSIVDEHFTANMESLLDGVEEGNVNWKTVVRNFYPDLDEAVKAAQKDLEKVKIEDEVTDVICDVCGRNMVVKYGPHGKFLACPGFPECRNTKPYLEKIGVTCPKCGKEVVLRKTKKGRKYFGCEDNPECDFMSWSRPVAEKCPKCGGYMVIKGNKIVCADEQCGYVTDRKNVEKDSE
(1618) DNA topoisomerase 3 [Clostridium acetobutylicum ATCC 824]
2
MGKILVLAEKPSVARDLAKVLKANINKKTHLEGNKYVVIWALGHLVSLADPESYGEKYKKWSMDTLPMLPKNMKLSVLKNTSKHFYDIKKVMERKDLDELVIATDAGREGELVARWIIEMAKWKKPIKRLWISSQTDRAVRDGFAHLRDGRDYENLYKSAKCRSEADWFVGLNVTRALTCKYNAQLSAGRVQTPTLYMIVSREEEIRKFKPKDYYTIEGKVKSFSMNWHDKSGDFKIFNKERAEKIEALVKGSKGKIVDVSESKKKKYSPALYDLTELQRDANRFFGFSAKETLSIMQRLYENHKLLTYPRTDSRYIPHDVVATLPDRLRAISIGKYSKFAAEILRSKINVHKGFVDDSKVTDHYAIIPTEERPALGALSNEEFKIYDLVVKRFLSIMLPPFEYIQTTVKAEVAGEIFIAKGKVVKSKGWKEVYDKTEDFEEKSELKDQMLPEMNKGEDITFSTVSIKKGQTKPPSRFTEATLLSAMENPQRYVSMDKISAKTLGETGGLGTVATRADIIEKLYKTFYIEKKGNEIVPTSKGKQLVNLVPSDLKSPLLTAKWEGQLDAISKGKLNGVSFVNEIKGYASKLVDDVKGSKDTFKYDNLTGTKCPECGKYMLQVNGKKGRMLVCQDRECGHRENLAMFTNVRCPECHKKLELRGEGEGRIYVCPNCSFREKYSSFQKRFKGNNNKVNKREVSNYMKKMKKEAEAPINNAFADLMSMFKDKN
(1526) DNA topoisomerase 1 [Clostridium acetobutylicum ATCC 824]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIDDNYNPKYITIRGKGELLDKLKKAAKKCDKIYLATDPDREGEAISWHLSKVLKIDESEKCRIEFNEITKNAIKTAIKCPRKININLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMVCSREKLINDFKPEEYWSIDAQVYKQSKKDKFTIRLTSFKGKKIKINNEEENEQIINSIKKDEFKVENVKEGTKNKNTLPPFTTSTLQQDANKKLNFSTKKTMSVAQQLYEGIDVKGHGTIGLITYMRTDSVRVSKEAQEAANDYILNEYGKEYLPPSPKLYKSKKNIQDAHEAIRPTYIELTPGMVKSSLKDDQYKLYNLIWSRFMASQMANCILNTLSIEIKNGEYTFRASGSNVKFEGFMRVYKYNIEEDEHNEKIPLLQKGDLLHTDKIDGKQHFTQPPARFTEASLVKTLEENGIGRPSTYAPIISTLIDRKYVKKEKKAIFPTELGNIVDNILSDYFKQIIDIEFTADMENKLDNVEEGKENWKEIVDEYFKPLKEAIDIAEKEVAKITIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVEKLKVKCPKCGGDVIVRRSKKGRKFFGCSNYPDCDFVSWFEPTEENCPNCGSFMVKKFSKAKGYYLQCSNQECKYEKSNPDPDKK
(1386) DNA topoisomerase [Clostridium acetobutylicum ATCC 824]
7
MRKILVISEKPSVGRDIANVLGCKTRGEGCLIGAKYIVTWAVGHLVTLWEPEEYNAIYKKWRFDTLPIIPEVMKIKPIDGTKKQFNIIKKLMNDNSVESLICATDAGREGELIFRYTYEAAECKKPFSRLWISSMTDEAIKEGFSTIKPGTEYDNLYHSAKCRSEADWLVGMNASRAYTLKYNVLLSVGRVQTPTLAIIVKRQKEIDNFEPKDYWEVVSKYEGFNGTWFDKETKESKIMDKKKADDLGAKILGQTGKVISIENKKKKQVPPLLYDLTELQRDCNKKFGFSAQKTLDIVQSLYEKRKMVTYPRTDSRYLSHDMVNKIKKTIGRLNINPYDKYVGEILKLSKLPMGKRIIDDSKVTDHHAIIPTDVKPNLSTLTKDELKVYDAIVRRFLCVFYPNYEYTITKIVTEVVEENFLTQGKTILKLGWMEFYKHDKKEKDDENSEPDELPKLKKNESVQVKDSEIKAKKTKAPSSYTEASLLSAMENAGRFVEDEQLKEQLKDGGLGTPATRASIIERLIQVGYIQRKGKSLHPTDKGMKLIEIVPYELRSPETTGKWEKGLSSISKGKMASERFMQSIKRYVQYIIQESVKVNRSVVFQNNDSKFPQKNKQLPEAIGECPFCKRGKVYENSKAFYCSEWKGGCKFTTWKDSLKNYGIQVDKDLEKKLLKERVLYNVFGIEPKSGEKTVYTLKMNNYGAVIAKTQ
Family distribution
Taxonomy tree
Clostridia