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Taxon : Aquificae
Informations
Name
Aquificae
Rank
class
# topoisomerases
20
Lineage and sub-taxa
Lineage
Bacteria
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Aquificae
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Aquificae
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(606) DNA topoisomerase 1 [Thermocrinis albus DSM 14484]
1
MMRLFLVESPTKAKTIQKYLGKDWKVLASMGHIKDLPEDELGVDLKTLEPRYVFVRGKRKVWDQIKRTAQKCESIYIGTDPDREGEAIAYFLWNLLKPLGKKLYRVRFYEVSKEAITLSVQKPEDSPNMNLVRAQMARRVLDRLIGYLLSPKLWVYLKNNRLSVGRVQSPALRLIVERERQIRQFKKKKFYYIKAVFEKNGHTFHLIWDYRFEKPENAKPYLEKLKSVPFEVERVVRGKVKKEPPKPFHTANLQAVASQKLGVGVDKVQKLAQKLYEEGFITYPRTDSLRMDEKKAQEFMNYIKKTLGEEYVGTLRKFKEKPTSQGAHECIRPVSLDRSPTGGVEEKLFTLIMKRTLASLASPALLEKTDVVVVPLCEPRMEFKGQWQRILFDGWLRIEEEELDLQEPPPLSEGEILLPKKVTLEERRTEPPPRYTEATLVKTLEKLGIGRPSTYAQIVKTLKDRGYVTEEKGVLKPTPLGEQVLDFLEKYYPRLVDYKFTAYMEEELDSVEEGKDWKTAVRYLFRAVAPEEELPSSTS
(1685) Reverse gyrase [Thermocrinis albus DSM 14484]
6
MIGAVFKNLCPNCGGDIGADRLQRGLPCERCMPQEGDPCHLLTEGQLRIWCDVEKKEEDWEKHFERCVGSKPWSLQKTWAKRVFMGHSFALLAPTGVGKTSFGLAMASFLAKEGKRSYIILPTRILVEQVVHKLQERFRLKEEDLLYFGDDSKKQKEEKRERLKEGRFKVLVTTSMFLYRNYQDIPSGFSFIFVDDVDSFLKTAKNVDKALYLLGFSEEDIDLAMRVIQLKTKRQKTDEDWEKIKEISQKLMEKRGEGVLVVSSATSNPRSNRVKLFRELLGFEVGTPTFYLRNVVDAYQEGTHNFLDWVKRLGGGGLLFVSSDKGKEEVDRVVNILRGEGISAVSYEELKEETLKDFEEGKIQLLVGIASYRNPLARGLDLPHVIRYALFLGVPKIVISLKFETNLSHLLWALSSIRSYIVKKLPQHMQKVDNWISQLRRYQYLTEEFVEERPDLKERLDQLRSQIGEFLSSEELVRIMSESEEITLRKTEEGYQLVVSDATGYLQASGRTSRMYAGGVTKGFSLIFVDDKKAFHHLVKKVRWFSDDINFLPVEGLDVEKIMEEVDADRSNVRAFMKGDVSVSSSDLLKPVLIVVESPNKARTIANFFGKAVRRRVGQHDLLETSVEDRYLMITASLGHVLDLVKEGGFHGVLMEKGVTPMYEVIEGKEYVVESLRRMASESMEVLIATDPDTEGEKIGWDLMQLLKPYNHSIRRMEFHEVTKKAILRALKEPRDINENLVKAQIVRRVSDRWVGFEFSQILQQAFGKSWLSAGRVQTPVLGWIIEREKEYRQKIYKVQVLIRDEKGRLKLELDFEDRKTAEAFFKELSYIEVTVKDQKEELRNPPPPFRTDTLLKEASDRYRFSLPKTMALAQTLFELGFITYHRTDSVRVSDYGMSIAREYIEEELGKEYVHTRQWGEGGAHECIRPTRPLEPEELRSMVLSGQVEGLTKEHILLYELIFRRFMASQTRAVKVKVKDVVIKALDRSVELSLVTDVLQDGWNKFLDLELNPDIPPRLDVRELKQMKKQPKAYLYTHGELVQEMKRRGIGRPSTYATIVEKLLERGYVIEKRGFLIPTKLGKKVYEYLRKREEIKAFLSEDFTRRLEEVMDRVEEGKADYEEVLKGLYRDIIKVEAIMEVTR
(1635) DNA topoisomerase 1 [Sulfurihydrogenibium sp. YO3AOP1]
1
MSEKKIVIVESPKKAKEISHFLGKDFIVKATVGHFKDLPENEMGVDLNTYEPKFVIKSQNHKKILSEIKKLAEKSEVIIATDPDREGYAIGFFMYEELKKKAKEVKRAEFHEITKEHIKEKIKNAVPFEKTNFGLFNAFLGRRVGDRIVGYTLSPIASREIGGRFSVGRVQSPAVRLIVEREIEIQNFKPTPYYVLSAVLRATSHVSPLTFTAIYENPKIENKEEAEKIYADIKDEKIATIKKVEKKQVKQSPKPPFTTSTLQQTASTVYRFAPEKTMMLAQDLFESGLITYHRTDSVRISEKAIDGIRNLINKEFGKDYLPEKIRVYKSKNTQADAHEAIRITHFVNLEEQKKLIKEKGLSEDHFKLLKLIYERTVASQMADAIFERTSAAVDIKGYTFKASGSILKFKGYKAVYDLEEEEDKEENQKLPDLKNKDVLTLEKINLEEKFTKPPARYTEGGLVKKLEELGIGRPSTYATIIKTIKERGYVVKENGSLRPTENAFHLIEYLNTRYNWVIDYSFTKKMEDFLDKVEENKKDWKEFVKQLHEKSGSKQNVKISKKMLDYAKDLAEKHGKSIEEIKDDPEKLKEFIDAHAEKNPSQKQIEYAKSLAEKTGLKLTEKELLDRKLLTKWINKAKKEMMKNYQLSEKQKNVLIKYGREDLVNNPVQALKFIKSKLSRYKK
(1572) Reverse gyrase [Sulfurihydrogenibium sp. YO3AOP1]
6
MIASIFKNLCPNCGGDITSERLYKGLPCDRCLPQEPKEEVCDVLKKGKFKILCDIDDEVSNWQNFFSKHIGSHPWSLQITWAKRFFLNCSFALLAPTGIGKTSFGLSVASYLTQKNKKSYIILPTKLLVNQTVKKLTQIFKLKEDQILFFGEENKKEKEAKLERLKDGDFSVLITTSMFLYKNHDKIPKDFSLVFVDDVDSFLKTAKNIDKALYLLGFDEKDINLALEVIKLKAKQNKTDEDWNKINQLTEKLRKIEAKRKGVLIVSSATSNPKSNRIKLFRELLGFEVGTPTFYLRNIVDSYDDIENHELSELIKKLGKGGLVFIPSDKKKEYVEEVKEYLTKKGVKAATYEEIDDEILKKYENGKIDVLIGISSYRNPLARGIDLPHVIRYAIFYGVPKIVLSLKFEANLSHLLWALSSIRAYILKKFPQYAIQIDKWITQLKKYQYLTEEFLQNNPNLKEKVDNLRLEVGQFLNSEEIINLLKESNEVTLRKDEDGYKLVVSDVTGYLQASGRTSRMYSGGITKGLSVILIDDKKAFNHLQKRVRWFSDDIEFVDFKSIDLAKILKEIDSDREKVRKILKGEIKFEKVESILKPVLIVVESPNKARTIANFFGKAVRRRVNDHEILETSIDDRYLMITASLGHILDLNKELGYYGVFVKDHIVPVYESIEGKEEIIESIRSVSFESLEVYVASDPDTEGEKIGWDVELLLKPYVKNIQRMEFHEVTKKAIINAIKNPRDFDENLVKAQIVRRVADRWVGFEYSQLLQKAFGKNWLSAGRVQTPVLGWIIEREKERKQKIYRITITLQQDSKKLELDIDYQNKQDAENIFNNLNNIEIIVKEVKEEDKNPLPPYRTDTMLKDASDRYRFSLPKTMELAQDLFELGYITYHRTDSTRVSDVGIALAREYIEEAFGKDYFQARVWGEGGAHECIRPTRAMETEELKSMILSGQYEGLTFDHIKLYDLIFKRFIASQMRAVKFKAKDVIIKGFGFELEKVLHTDIIQDGWNKILPAELHPDLEGIIDISNNKQFKIMPKAFPFTHGELVFRMKERGIGRPSTYATIIAKLLERKYVIEKKGLLFPTSMGIKVYQYLNSLKHVREFLSEEFTRKLEELMDEVEIGEKDYQAILFELFEKIKIRRDN
(759) DNA topoisomerase 1 [Persephonella marina EX-H1]
1
MGDKKTKKIVIVESPKKAREIQKFLGKEYSVKATIGHFKDLPEKEMGVDLKTFKPKFVIKSKNHRKMLSEVKKLAENAEVYIATDPDREGYAIGYFMYEELKKKAKDIKRAEFHEITEKHVKDIIKKAPKFEQTNFGLFDAFLGRRVGDRIVGYTLSPIASKEIGGRFSVGRVQSPAVRLIVEREREIQQFKPTPYYVLTAILKKDDTQFVSYYEKQRLEDKELAKKIYEGIKTVRQAVVKDIKKKEVKQSPKPPFTTSSLQQTANSQLRFAPEKTMMLAQDLFENGLITYHRTDSVRISKEALTGIRKFIEKSFGKEYLPSKTRVYRSKNTQADAHEAIRITNFVDLDTQRKLVSEKGLTEDHFKLLKLIYQRTIASQMKDAVYDRTTALFDIGGYVFKTTGSVLKFDGYKKVYNIEDKEETQRLPDLKKGETVEKVDQKLEEKWTKPPGRYTEGSLVRKLEELGIGRPSTYATIIKTIKDRGYVVKEGGSLRPTEAAYHLIDYLNGKYNWVIDYDFTRRMEEFLDAVEEKKKDWKEFVEELYRKSVEGAKNVISKKMKDYALDLAKKHGKDISDIIDDPEKLKEFIDQHKETKPSEKQIAYARSLSEKTGLELPEDVLQDKEKIKRWINKAKKEAMKSYKLSEKQKAVLIKNGKEDLIDKPEKALKWLEMYFRKRRKK
(406) Reverse gyrase [Persephonella marina EX-H1]
6
MSAIPIVYKDICPNCGGEITAERLEKGLLCESCLPEEIPREDICGILGYGRFVSICELWDKVNDFKSYFKGIINNDLWSIQETWTKRFFLNISYALLAPTGIGKTTFGLVLSKYLSEKEGKKTYLIFPTQVLVNQAYDRLVSFGMDPEKLLAYSTKFAKTKKKQEELKEKIKNNQFDILITTTMFLYKNIDIIPKGEFSLVFVDDVDSVLKSAKNIDKILMLLGFSEEDIQDTLKFITFKQKIFRQGQPEEKDLEIFNRWQEKINRISQKRKGVLIVSSATSNPRSKRVNLFRELLGFEVGRPSLTLRNIEDLYEKPDDVWETSVERIKKLGSGGLVFLSSSETRETLERYVKFLNEKGINAISYEDLMDSLEKFRSGEIPVVVGFASYRNPIARGLDLPDVIRYALFVGVPKLQFNIRFEEEFIHLYYFMLTLTPFLIKKKLIDPQEVRQLYEYINFLKVYAFIPEEKLDREKAERLREIQVYVKSIVEKPEVFDQIKDSPEITLKKTDEGFILITADVTGYIQASGRTSRLYAGGLTKGLAYLLVDDDKAFYSLQKKVRWFSEDIQFKPADQVDLEKILKEIDQDRENVRKVLSGEIIVEERQSFKTTVVIVESPNKARTIANFFGKPLRRKLKGIDAYEIAIGDKFLTIIASKGHIFDLNKEEEYFGVRKNSHFIPVFEPIDEGRKHIIEGIRELDLEVQEVFIATDPDTEGEKISYDLYLLSKPYNFNVKRAEFHEVTKKAFLEAVENYRDIDKNLVKAQLLRRISDRWIGFTISQYVQEKLHRHYLSAGRVQTPVLEWIIERTDQAKQKIAVVRVFIDNIPVEFSFEDRNRAKWFYQNIQFVIVSVKEKKEEKLFVRPFSTDTMLTASARELGFSPQETMSLAQDLFEAGLITYHRTDSIRVSDAGVFVAKEYIQENFGSEYIKIRTYSTYEGAHECIRPTRAVDADELRSMVYTMNLQGITRKHIRLYDLIFRQFIASQMREAVVEKVVYSVRAFDEEVETDLITDIIQHGYDLILPIRTDKLPEGKVDIKKKSYHLKPKVSYYTFGEIIKEMKEKGIGRPSTYAITVQKLLDRHYIIERRGYLFPTKLGRQVMELIKRREDIYRFVNESFTKELESLMDRIEQGKADYEKELEKLFKELEEKKLFFKVEIGKYSYEE
(502) DNA topoisomerase 1 [Sulfurihydrogenibium azorense Az-Fu1]
1
MKKVLIVESPKKAKEISHYLGKDFIVKATVGHFKDLPEDEMGVDLQTYQPKFVIKSSNHKKILSEIKKLSQDAEVYIATDPDREGYAIGYFMWEELKKKAKTVKRAEFHEITKDHIVEKIKEAVDFEKTNFGLFNAFLGRRVGDRIVGYTLSPIASREIGGRFSVGRVQSPAVRLIVEREREILNFKPTPYYVLTALLEKDGIKFTALYEKQKIEDKQEAEKIYQDIKDEKTAAVEKVEKKQIKQSPKPPFTTSTLQQSANSVYRFPPEKTMMLAQDLFESGLITYHRTDSTRLSDQAITGIRKLIEKEFGKEYLPKNPRVYKSKNTQADAHEAIRITNFVPLKDQEALVKEKGLSEDHFKLLKLIYERTVACQMEDAVFERTNITLKIKNHTFKASGSILKFKGYKAVYDLEEDDEESQSLPKIEKNQLINIQSINLEEKFTKPPARYTEGSLVKKLEELGIGRPSTYATIIKTIKERGYVVKEGSSLKPTDLAFHLVDYLNQKYNWVIDYNFTKKMEEFLDKVEENKKDWKEFVKHLHQKSVSTTRSKVSKKMLDYAKDLAKKHGKDIDAILDDPQKLKEFINDHADKKPSEKQITYAKSLSEKTGLPLTEKELSDKKLLTKWINKAKKEALKNYQLSEKQKNVLIKYGREDLIEKPAEALKFIASKLKRFKK
(999) Reverse gyrase [Sulfurihydrogenibium azorense Az-Fu1]
6
MIYAIFEKLCPNCHGEISSYRLEKGLPCKKCLPDEDLDVCQHVKPGDIKQLCHLQDTLQTWQEHFQTYIKSKPWNLQNTWAKRVFLKHSFVLLAPTGIGKTSFGISMASFLAKQGKKSYILLPTKLLVKQVYEKVKNFGVDKKDILAIGLEKSNKEKEENKERLKNADFKILITTSMFLYKNFEIYPRDFEFIFVDDVDSFVKTAKNIDKALYLLGFTQEDIEKALILIKLKAKPNKTQEDWDKINQLTEYLQKQRKKITGVLIVSSATSKPRSNRVKLFRELLGFEISSPTFYLRNIVDSYDEEYSFEKLLYWINKLGKGGLVFIPSDKGKEFVDEVVEKLNKHKIKAVSYEELDDKNLKKFEEGKIQVLVGISSYRNPLARGLDLPHVIRYALFYGVPKISISLKLEENLSHMLWALTSIRSYVIKKFPEITIKINQWITQLQKYQNLTLDFIQNNPQLKEKIENLQKEIRDFFQRPEVLEVLKSSDEIVLKQKEDGYYLIVSDATGYLQASGRTSRLYAGGITKGLSLILIDEKSAFKHLNKRVKWFSEEIEFVNINQVNLDQLIKQIDEDREKVRNFLTNSTKTISSSDLLKPTLIIVESPTKAKTIANFFGKPVRRKINQTEVLETSTEGRYLMITASLGHILDLVKNIAYHGVIVEDKEIIPIYETIEGKEETVENLRRLAIENMEILLGTDPDAEGEKISWDLQDLLKPILKNIKRIEFHEVTKKAITKAINDPRDINENLVKAQIVRRVADRWVGFEYSQLLQKEFQKNWLSAGRVQTPVLGWIIKRQQEASKKIYVINVSIPVEDKKFSFEITFETKEEAEKFYQNLKEVEVVVEKRYEEVENPPPPYRTDTLLKDASDKFRFTLPQTMDLAQTLFELGYITYHRTDSIRVSDAGIYLAKEIITQEFGENYFKPRVWGEGGAHECIRPTKNITPEDLESLMLSKQIEGLSYNHIKLYKLIFNRFIASQMIPVKVEMADIVIKALNFEIKETIKTKVLQDGWNLVLGIETRPLIEGKIDVQEYKNLLQRPKAYLYTHGEIVKEMKEKGIGRPSTYATIIAKLLERGYVIERKGFLIPTNLGKTVYNFLTNKPNLKEFLSEEFTRKLEEIMDKVEEGKEDYITVLKDLFVKVRKIS
(392) Reverse gyrase [Thermovibrio ammonificans HB-1]
6
MKVAEFHRMCPNCGRIISDKRLKAGLPCERCLPEFLKWKEREEICEAIEELQNFQQICRLDRFVKEFTEFFKEKTGFTPWSLQIMWAKRVALKKSFTMIAPTGVGKTTWGLVTSAFVKGKVYVLVPTKLLVLQTVERLKKLTDKKVVAYTGKKREKETIASGEFEILVTTTNFLYRNFEIIPKPFDFVFVDDVDSLLKSAKNVDKVIMLLGFTEEDVELAMKVIDLKAKAAKSSGRELQKLLERIKRLEKHLERRREEIDRVLVVSSATSQPRSKRVKLFRELLGFEVGKSATALRNVEDVLIFTEKDELQLAVETVKKFGKGVFLFVSADRGREYVDRVVETLNSNGIPAVSYEEFTPENQQRFVNGEIWAAVGISSYRNPLARGIDLPQAVRYALFLGVPKMEFGVKLSLSPVKLFGLLLVLRELFSEEELPKVNGYISYLKRYLTLKEELLDRYPKIKSRLQEIKEFLEAHLSNPEFLKKIRESETVSLKEKNGELVLVVGDAAGYVQASGRTSRMFAGGLTKGVSLMVVDDVKALNSLRKRVMLFLEDVEFKVLETDKGKEFAGKLGLPTITEEELKAVFKQVDRDRKRVREILEGKVTPETKSLVTTALVVVESPNKARTIANFFGKPVRRRVKDVDAYEINIGNKLLLLAASKGHVFDLTVRDGVWGVKEEDGHYIPVYDTIKYCTKCNEQTTENFCTKCEGRPDVDKITVVEALRELGLEIDEVYIASDPDTEGEKIGWDVGCNLKPYQMNMKRMEFHEITKWAFLKALEEPREIDENLVKAQIVRRVADRWVGFSLSQHLWKVFNRRWLSAGRVQTPVLGWVIERFEESKEKIGLLTVECEGVSFTFKLEEPQKLKEVKADKVKVKVREVSVTEKNPKPPFNTGELLKEAADRLKLSAERVMEVAQELFESGFITYHRTDSTRVSTAGMGVAKEFITERFGPQFVKLRPWGEGGAHECIRPTRPLDAEGLRTLVTVSGSTVKMERDHYAVYDLIFRRFIASQMVPAEVERVKAEVKLLPDELQKEEEFTTKITKDGWNLILPQIEVTELPFEPTEGESYYLPVKAVHKRLIPKVLPYTQGELVEEMRKRRIGRPSTYAKIVQTLLDRKYVVERRHRLYPTKLGIEVYNYLAENFPHYTSEEFTRELEELMDKVERGEADYQKIIEELKPVLQFANVDPKQTVGE
(1237) DNA topoisomerase 1 [Thermovibrio ammonificans HB-1]
1
MGKKLIIVESPAKAKTIQKYLGKDFIVKASMGHVIDLPEKEFGVDIEKGFKPKYTTIKGKEKVLKEIKEAAKKSDEVYLATDPDREGEAISWHIANALKRVKKDNIYRIRFHEITKRAIQEAVKNPDTIDEKKVNAQQARRILDRIVGYTISPLLSRRFKRALSAGRVQSVALRLICDREEEIRKFVPKEYWTVEAKFAKGSEELPAKLWKVDGKRLEKFDIPNEKAAKELVERAKGAAFSVAKVERKERRRKPPAPFITSTLQQEASRRFGFPAKVTMQIAQELYEGIDLGSERVGLITYMRTDSTRVSDEAVKEVREFIKEHFGQNYLPKTKRSYETKKPKSAQDAHEAIRPTSVFRTPESVKPYLTPEQFKLYDLIWRRFVASQMKDAVFNTVSVDVEGGGLTFRSTGSTLKEEGFLKVYPVEVEEKLLPELNKGEALELKEVKGVQHFTEPPPRYTEGTLVKALEEEGVGRPSTYATIISNIIQRGYVAKEKQKLKPTELGEFINSLLKKLFPKIVDVKFTANVEEELDKIEEGQKEWKELLKEFYFGEFKELLDRAEKELKQIKGEEIGRECPRCGAPLVKIHGRYGAFIACSAYPECTYKESIKEEPQKLDRKCPECGGELVIKNGKFGRFIACSNYPECKHTEPLTFGKCPKCGEGEVVERRSKKGKRFYGCSRYPDCDFVSSKPPKGGES
(1528) DNA topoisomerase 1 [Desulfurobacterium thermolithotrophum DSM 11699]
1
MGKKKLLIVESPAKAKTIQRYLGKDFIVKASMGHVIDLPEKEFGVDIEKDFKPKYVTIKGKDKVLKEIRKAAKESEEVLLATDPDREGEAISWHIANALKRIKKEGIYRVRFHEITKKAIEEAIKNPDKIDENKVNAQQARRILDRIVGYTISPLLSKKFKKALSAGRVQSVALRLICDREEEIRKFVPKEYWTVEGIFRKETSKFPAKLFAVDGKKLDKFDIPDKNSANQLIDRAKKAVFVVTRVERKERKRKPYPPFITSTLQQEASKRFGFPAKLTMQIAQQLYEGIDLGKERVGLITYMRTDSTRVSDEAVKEVRNFIEENFGLEYLPKTKRSYETKTPKSAQDAHEAIRPTSVFRTPESVKKYLTSEQYKLYELIWKRFVASQMKDAVFNTVSADIEGNGLLFRATGSTLKEEGFLKVYPVEFEEKLLPDLNEGDKVEQEDIKGIQHFTEPPPRYTEGTLVKALEEEGVGRPSTYATIISNIIQRGYVEKEKQKLKPTELGEFINDILKKLFPKIVDVKFTANIEEELDKIEEGKKEWIELLKEFYFGEFKELLEKAERELKSLKGEEIGRECPKCGAPLLKIHGKYGTFIACSKYPECKYKESLKGEPKKTGEICPKCGGELVIKNGKYGKFIACANYPKCKYTAPLTYGKCPKCKEGDIVERRSKKGKKFFGCSRYPECDFISNKPPSEAKK
(293) Reverse gyrase [Desulfurobacterium thermolithotrophum DSM 11699]
6
MKLAEFHRMCPNCGGIISDERLKAGLPCEKCLPKELFYTNRKEICNALGNKLQDFKKICLLDEFTENYVKFFKEKTGFTPWTLQVMWARRVALSKSFTMIAPTGVGKTTWGLVTSAYLSGKVYILVPTKLLVLQTVEKLSKLTNKKIVAYTGKKSEKGTIQSGNFEILVTTTNFLYRNFEIIPKPFDFVFVDDVDSLLKSAKNVDKVIRLLGFTEEDISIAEKVLELKSLVAKFGEKVDRKLIEKLKKLENFLEKRKSEIKNVLVVSSATSQPKSKRVKLFRELLGFEVGKSATALRNVEDVLIYTDKDYLEETVKIIKKYGKGVFVFISEDLGKDYVEEVVNFLNKKGISTVSYENFSSENQGNFIDGKIQAVVGIASYRNPLARGIDLPQAVRYAVFLGVPKLEFNLKLSLAPVKLFGILLVLRELIEDKTKVMSYLSYLKKYLSLKKELLDKYPKVKEKLEEIKGFLESYLSNKEFLEKVRASEDISLKEKNGELFVVVGDATGYVQASGRTSRMFAGGLTKGVSLMLVDDLKALNSLKKRLSIFLEDLNFKVLDYDKGKELAEKFGFELIDEEKLNKIFKTVDEDRKRVKEILEGKIKAETKNLVNTALIVVESPNKARTIANFFGKPVRRKVLDIDVYEINIGDRLLLLTASKGHVFDLTVRDGLWGVKEEESSYIPVYDTIKYCTKCFEQTTEPFCSKCSGKPDVDKITVVRALREVGLEIDEVYIASDPDTEGEKIGWDIGTVIKPFQKKVRRMEFHEVTKWAFMEALKTPKEIDENLVKAQIVRRIADRWVGFALSQHLWKVFKKHWLSAGRVQTPVLGWVIKRYEESKEKKGIIVVETKAGSFRFEFDNLEEFQKIAIDKVEIKVKEKSIFEKNSLPPFNTGELLKEASNNLGISAEETMNIAQALFESGFITYHRTDSTRVSTAGMGVAKEYISQKFGAEFIKLRSWGDGGAHECIRPTRPLDAESLKALVLVSGSSSKMTKNHFRIYDLIFKRFMASQMIPTKVEKCKLLVKLLPVEKEEEEERIAKIVKNGWNLIQPLNLEPLSVELKKEKTYYFEIISYVKKKVPKVFPYTQGELIEEMRKKEIGRPSTYAKIVQTLLDRKYIIEKGKFLYPTKLGIEVYNYLSEKFPDYTSEEFTRELENIMDKVERGEEDYQKVIENLKPILEIRYS
(516) DNA topoisomerase 1 [Aquifex aeolicus VF5]
1
MELFIVESPTKAKTIQKFLGKGFLVKATLGHVKDLPEKELGVDLRTLKAKYVYKRGKKKLVEQLKKLSRRSSIVYLGTDPDREGEAIAYFLKKDLEKVNKNIKRAVFYEITPEAIRESIRNAGDVNMNLVYAQFARRILDRLIGYLISPILWKEFKNYKLSAGRVQSPALRLIVEREREIQNFKVKKYYYVKALLRKGSEEFWAIYDYRYENPSDAKIIAKKLEKGYFSVYKVEKKKEKVSPPKPFITSDLQSEANAKFGFSSERTQKLAQELYEKGYITYPRTDSYRMNEKKAKEFMNYIEKKYGKEYVGRLRRFREKATAQGAHECIRPTSLREEIPEREELRLLYDLIFRRTIASLMKEMLLEREKVTVEAITPELKHPVYLVAKGLKIVFDGWSRVYPSEITEEKLPELYEGDLLDLVKTTLEERKTQPPPRYTEGTLIKTLEKLGIGRPSTYATIVKTLKERGYVEVKKKALVPTEIAFQVVEFLMERFPTLMDYKFTAQMEEKLDLVEEGKLNWKSVVYEFMEKIFGKELEMVR
(827) Reverse gyrase 1 [Aquifex aeolicus VF5]
6
MIKAIFDTLCPNCGGEISAERLLKGLPCEKCLPEEVNREEVCQKLENGSFKEFCELLSELKDWEDFFKEILGTSPWSLQKSWARKVFLGRSFAMLAPTGVGKTTFGLSMASYLAKQGKKSYIILPTQLLVEQVSERIKTFGVDEDRLIVWGKLSEKKKKELKERIQKGDFDILITTSMFLYKNYEILPKDFSFIFVDDVDSFLKTAKNVDKVLYLLGFSEEDIHKAFELIRLKEKPNKSEEDWEEIKKRSEELREIAKKKKGVLAVSSATGNPRSNRIKLFRELLGFEVGKPSVLLRNIVETYEETQNLKETLLKRVKEFGKGGLVFVSSDYGREAVEEVKKFLESHGVKAVTYEEDLKLFEKGEAQVAIGISSFKNPLARGIDLPHVVRYAIFYGVPKIRVPLKVETSVSHLLWALLSLRPIILKDEKLKSEVKKVDTWIQRLRRYSFLSDDFVEERPDLKDRIENLRKEVQEFLLREDIVEKIKNSEELTLRLGEEGFELVVADVTGYLQASGRTSRMYAGGLTKGLSHVLVDDRRAFKNLEKKVRWFNQDINFKKIEEVDLKEVLREIDEDRKKVREILEGKVKAEQKEHVKPVLVVVESPNKARTIANFFGKPMGRKIGGIDVLEVMVGDLYIMITASLGHVFDLVKDKEFHGVIAKNGEYVPIYEVIEGKENIVKGLRELAQEVDTVLIGTDPDTEGEKIGWDLGALLSPYIPNVERIEFHEVTRKAIKHAVENPRDFNENLVKAQLVRRIADRWVGFEVSRIVQQAFDKHWLSGGRVQIPVLGWIIEREKLYRKKKHVVQITFKENGRWLRLGFEFQDKKEAKEFYENLKEIDVEVLEEREELKNPPPPFTTDTMLKEASDRYRISVPKLMQLAQELFEYGLITYHRTDSTRVSDVGIGVAKEWISEELGKELFYPRVWGEGGAHECIRPTKPLDVEDLRSMMLAGQLQNLTREHLLLYELIFKRFMASQMKPVKVKTKKVKVKALGREQELILTTEILEEGFNKVYPLELQPDLKGSVYVEDKKELKSVPMAYLYTQGSLVEEMKRRGIGRPSTYATIVSKLLERGYVIERHGFLIPTKLGKQVYEFLKSREKIMPFVSEEFTRKLEELMDKVEEGKEDYLQVLDELYKKVNEFEKANV
(1567) Reverse gyrase 2 [Aquifex aeolicus VF5]
6
MALELIERGCPNCGGVISSDRLEKGLPCSKCLPKPTEEKVCDALEELKTLKYLKPFCDTDKSLERFINFFEKAVGAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMSLFLKGRVLAIFPTRLLAQQAGDRLSELAQKVGVNKKILIYQSKKNIREQFLNGDWDILLGTNMFLHKNFENLINFKFKLIFIDDIDSFLKRGKNVDYLFKLLGFSGEEIKLALKENKTQRDYDRLARIRKRKRDTVLIVSSATLKPRGKRAYLFRNLLGFDVQKAITTLRNIVDVAEPVKDLEEALEKSVELIKKLGKGGLVYLSVFYGKDKVQEVKEFYRKHGINAVSYLDYKPEELYQILEKGEFDVAVGISHITNPLVRGIDLPHIIRYAVFLDPPKHVFPTELTLSPPLLHGLLLTLLNLFEGDDRLKAIQYVMYLKRYLTLREEQLDNYPRIKERVEEIKNFLENYLKDENFLKKIKESEDISLVPKEGKLYIVVGDANSYIQASGRTSRFIAGGMTKGLSVVYYSDPKAFYSLKKRLALYYMTQEIEFKRLSEVDLNKLIKEIDEDRKRAREILQGKGVAQIKDLFKTTLVIVESPNKARTIAGFFGKPQMRLVEDSVAYEVPLGDRLLVITASLGHVLDLVTDKGFFGVLDDTYPYLPVYDTIKICRETHEQHTEYEYLKKRCKGKIEDKLEIIKGVREVSYEVDEVFIATDPDAEGEKIGYDLYLLSKPFNFNIKRAEFHEVTPKAFREAIQNPREVDLNLVKAQLVRRILDRWVGFTLSHILWDAFGKKWLSAGRVQTPVLGWVIKRYEESKEKKGEILLHVNDFPLKIEIEDLMFAKEIFKDLELADISLSNPQEEEKRPLPPYTTDTVLEDANEKLHLSAHKTMKILQELFEAGYITYHRTDSTRVSDAGKYLVAKPYITKMFGEEYFYPRSWGEGGAHECIRPTRPLEPKDLEFMITAGIAEFEDPENALKVYELIFKRFMASQMRPAKVITEEIILKLPYFEWKERVVTEVKEHGFDLMYPTFKVFPKKEKLEITHKEFREVPKVYPYTQGTLIQEMKRRGLGRPSTYAQIVQTLLERHYVVEEKGFLIPTDLGREVYEYLTKHFPEWTSEELTRKLEEAMDKIERGELDYMEVLKEVHRIKVLLKEEKAFKK
(1800) DNA topoisomerase [Hydrogenobaculum sp. Y04AAS1]
7
MKRLILAEKPSVARDIASALCKSLNKDASKKGYFECEEKNLYITWAIGHLVEIDDEIAPRKWSLETLPILPETFKYKVIDKTSNQFKVISKLLKEVDEVVIATDAGREGELIARLILMLNHFKGSVKRFWTSDALTKEVIIREMENLKDASLFDSLYYSALARSHADWIVGINLTRLMTVKAGGGVWSVGRVQTPTLKLIVDRYKEFKDFIPKEYYVIKAVFSACDDCIDTISKSYVGLLVLDKAQEKTYKTLKDALEEEESEKTAGAPKSKYFTPLLKESKNQIMEKLEKVKEGIVKDVKITKRKENPPLLHSLTSLQREANRIYGYSSMRTLNIAQKLYESYKCLSYPRTDSNYLGEDQETKNLVKNLLKKLVDKNIYEFLSKNINKVGKRVFDSSKLTDHHALIPFGPIPEDASNEEKNIYNLVFRRFVGAFMEPYEYAIITIKTMLGEFTFISNINIETLTEEEYQKTYLSLYRPYKLEIKESLSEDEDIEPNNIERYQRVSELRNRRSHQGEERNAYSTLDFDYIKSLKPDDKVYKRSLEALQKFTKPPALYTEGTLLKVMEKLGLGTPATRASIIETLLERKYISRVDKSLLPTLKGEELIKSLRDSDVSKPEMTTTWEEELERIYKERKSKEGYIRFMHNIKEFVSDNIDRLKFVEMKRVPMATKKMIEFARSLARAKNIKPPHSTDYETIKAFIEEHNPKKEGNTEENTNGYTPPTEKQIAFAKSLAQKLNQEIPEDAYVSTKTMSEWIKNAIKQTGYKKSYRRGKK
(235) DNA topoisomerase 1 [Hydrogenobacter thermophilus TK-6]
1
MNLFIVESPTKAKSIAKYLGNGWVVRATLGHIKDLPERELGVDIKTLEPKYVWLKGKKKIVDGIKKAAKKAKKIYLGTDPDREGEAIAYFLKEELLKVNTSIYRATFYEITKKAITEAIGGASDINLNLVSAQFSRRVLDRLIGYKLSPFLWRDLKERGLSVGRVQSPTLRLIVERERQIQNFKRKKYYYIKAEFVVDGVEFSAVFKQRFEKPSNAEPFMKKLKDVMFVVKSVSKEMQKEPPPKPFNTVSLQAEASKILGISVDKVQKMAQKLYEEGLITYPRTDSYRMNKEKAQEFMKYIERTYGKDYVGRLRKYKEKALAWGAHECIRPTSLDKKPESVLELKLWSLISSRALASLSSDAIREKFFVVLLALSDHTLEFTAEGSKLVFDGWTRIYPKEVKDRALPHLEEGQVIKPKRIYIEEVEVPPPPRYTEGSLVRTLENLGIGRPSTYATIIKTLKDRGYVVLEKGYLKPTEMAFKVVDYLMEKFPNLMDYGFTKYMEDNLDAVEEGKKDWKEVVRESYRRVLNAKE
(1082) Reverse gyrase [Hydrogenobacter thermophilus TK-6]
6
MIKSLLLKLCPNCGGDITAERLIKGLPCQNCMPDEDKNLCEALKEGSLKKLCTALEQVSDWEKLFEKHIKSKPWSLQVSWAKRVLLGSSFALLAPTGIGKTSFGISMALYLASKGKKSYIVLPTKLLVKQVSARLKKMGADKKLLLAFGDEEGKKKEENKERLTKGEFLILVSTSMFLYKNYHLIPRDISFVFVDDVDSFLKTAKNIDKALYLLGFKEQDVEKAMNLIRIKEKFKKTEEDWEKIRELSNEIKSISEKVKGVLVVSSATSNPKSSRVKLFRELLGFEIGTPTFYLRNIVDAYADYQELSLAEWIRKLGKGGLVFVSSDKGKEEVEKLIRELEKANISAVSYEDMDESKLSDYERGKVDVIVGIASYRNPLARGFDMPHVVRYAIFYGVPKIVLSLQFEKNLSHLLWALASIRPYIAKHIKDYINRVDDWIVRLKRYQYISDQYMEDKKDLKERIEKLREEVKNFLMKEEVLRLLETSEDITLRFKDGDYQMVLSDATGYIQASGRTSRMFAGGITKGLSITLIDDKRAFNHLKKKVRWFSEDINFVPVSSVDLDSLLSQIEEDRKKVKRYLSGEAATERPDLLKPVLIVVESPNKAKTIANFFGKAVRRRIGQHEVLETSLEDRYLMITSSLGHILDLNKEAGFHGVYVNSQIVPVYESIEGKEEVINSLRRMSVEVSEVLVATDPDTEGEKIGWDIMELLKPYVKDIKRMEFHEVTKKAIVKAIKEPREFNVNLAKAQVVRRVADRWIGFEFSQYLQQAFGKNWLSAGRVQTPVLGWIIEREKEYRKKIYKVVVRVEKDGKLFRVEFSFENKEEAREFYNKLNYLEFEVLETKEEFKNPPPPYTTDSLLKDASDRYRFSLPKTMQLAQTLFELGFITYHRTDSTRVSDQGISVAKEYIKEELGEAYSHPRTWAEGGAHECIRPTKPLDTEELRSIVLSGQVEGIGKEHLMLYELIFRRFMASQTRPVKVRTLEVLIRALSSEQRHTLVVDVLEDGWDKFLHLETHPTLEGKVYVEDKKELRELPKAFLYTHGELVQDMKKKGIGRPSTYATIVEKLLERGYIIERKGFLIPTKLGKEVYEYLSKREEIKGFLSEEYTRELENLMDMVEQGSANYENILKNLYRSIMFLEPALEVER
(234) DNA topoisomerase 1 [Hydrogenobacter thermophilus TK-6]
1
MNLFIVESPTKAKSIAKYLGNGWVVRATLGHIKDLPERELGVDIKTLEPKYVWLKGKKKIVDGIKKAAKKAKKIYLGTDPDREGEAIAYFLKEELLKVNTSIYRATFYEITKKAITEAIGGASDINLNLVSAQFSRRVLDRLIGYKLSPFLWRDLKERGLSVGRVQSPTLRLIVERERQIQNFKRKKYYYIKAEFVVDGVEFSAVFKQRFEKPSNAEPFMKKLKDVMFVVKSVSKEMQKEPPPKPFNTVSLQAEASKILGISVDKVQKMAQKLYEEGLITYPRTDSYRMNKEKAQEFMKYIERTYGKDYVGRLRKYKEKALAWGAHECIRPTSLDKKPESVLELKLWSLISSRALASLSSDAIREKFFVVLLALSDHTLEFTAEGSKLVFDGWTRIYPKEVKDRALPHLEEGQVIKPKRIYIEEVEVPPPPRYTEGSLVRTLENLGIGRPSTYATIIKTLKDRGYVVLEKGYLKPTEMAFKVVDYLMEKFPNLMDYGFTKYMEDNLDAVEEGKKDWKEVVRESYRRVLNAKE
(1081) Reverse gyrase [Hydrogenobacter thermophilus TK-6]
6
MIKSLLLKLCPNCGGDITAERLIKGLPCQNCMPDEDKNLCEALKEGSLKKLCTALEQVSDWEKLFEKHIKSKPWSLQVSWAKRVLLGSSFALLAPTGIGKTSFGISMALYLASKGKKSYIVLPTKLLVKQVSARLKKMGADKKLLLAFGDEEGKKKEENKERLTKGEFLILVSTSMFLYKNYHLIPRDISFVFVDDVDSFLKTAKNIDKALYLLGFKEQDVEKAMNLIRIKEKFKKTEEDWEKIRELSNEIKSISEKVKGVLVVSSATSNPKSSRVKLFRELLGFEIGTPTFYLRNIVDAYADYQELSLAEWIRKLGKGGLVFVSSDKGKEEVEKLIRELEKANISAVSYEDMDESKLSDYERGKVDVIVGIASYRNPLARGFDMPHVVRYAIFYGVPKIVLSLQFEKNLSHLLWALASIRPYIAKHIKDYINRVDDWIVRLKRYQYISDQYMEDKKDLKERIEKLREEVKNFLMKEEVLRLLETSEDITLRFKDGDYQMVLSDATGYIQASGRTSRMFAGGITKGLSITLIDDKRAFNHLKKKVRWFSEDINFVPVSSVDLDSLLSQIEEDRKKVKRYLSGEAATERPDLLKPVLIVVESPNKAKTIANFFGKAVRRRIGQHEVLETSLEDRYLMITSSLGHILDLNKEAGFHGVYVNSQIVPVYESIEGKEEVINSLRRMSVEVSEVLVATDPDTEGEKIGWDIMELLKPYVKDIKRMEFHEVTKKAIVKAIKEPREFNVNLAKAQVVRRVADRWIGFEFSQYLQQAFGKNWLSAGRVQTPVLGWIIEREKEYRKKIYKVVVRVEKDGKLFRVEFSFENKEEAREFYNKLNYLEFEVLETKEEFKNPPPPYTTDSLLKDASDRYRFSLPKTMQLAQTLFELGFITYHRTDSTRVSDQGISVAKEYIKEELGEAYSHPRTWAEGGAHECIRPTKPLDTEELRSIVLSGQVEGIGKEHLMLYELIFRRFMASQTRPVKVRTLEVLIRALSSEQRHTLVVDVLEDGWDKFLHLETHPTLEGKVYVEDKKELRELPKAFLYTHGELVQDMKKKGIGRPSTYATIVEKLLERGYIIERKGFLIPTKLGKEVYEYLSKREEIKGFLSEEYTRELENLMDMVEQGSANYENILKNLYRSIMFLEPALEVER
Family distribution
Taxonomy tree
Aquificae