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Taxon : Thermotogales
Informations
Name
Thermotogales
Rank
order
# topoisomerases
23
Lineage and sub-taxa
Lineage
Bacteria
>
Thermotogae
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Thermotogae
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Thermotogales
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Topoisomerases
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Name
Family
Sequence
(627) Reverse gyrase [Thermotoga maritima MSB8]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(91) DNA topoisomerase 1 [Thermotoga maritima MSB8]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGVDLEKDFEPEFAVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGRKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITVNFDGLTAEIDVKEKKFFDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPEEAGKYLNSDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFPFEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFDRNDRIVVDFPTNQKCSCGKEMRLSFGKYGFYLKCECGKTRSVKNDEIAVIDDGKIFLGRKDSESGSPDGRSVEGKGNLSEKRRKGKKGS
(90) DNA topoisomerase 1 [Thermotoga maritima MSB8]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGVDLEKDFEPEFAVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGRKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITVNFDGLTAEIDVKEKKFFDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPEEAGKYLNSDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFPFEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFDRNDRIVVDFPTNQKCSCGKEMRLSFGKYGFYLKCECGKTRSVKNDEIAVIDDGKIFLGRKDSESGSPDGRSVEGKGNLSEKRRKGKKGS
(626) Reverse gyrase [Thermotoga maritima MSB8]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(1106) DNA topoisomerase 1 [Thermotoga neapolitana DSM 4359]
1
MSKKKKYIIVESPAKAKTIKGILGPEYEVFASMGHIVDLPKSKFGVDLKNDFEPQFTVIKGKEKIVEKIKAISKVGEIFIASDMDREGEAIAWHVARLTNTLGKRNRIIFSEITPRVIKEAVKNPRKIDMNKVHAQLARRILDRIVGYSLSPVLWKNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRVVVKFHGLEAEMITKEKTFLEEDVLKELQSIEELVVEEKTVSRKKFSPPDPFKTSSLQQEAYAKLGFSVAKTMLLAQQLYEGVETKEGHIAFITYMRTDSTRVSDYAKEAARELIEKDFGKEYIGTGRRKKSRTARIQDAHEAIRPTDVFMTPEKISKYLNPDQRKLYELIWKRFFASQMKPSEYEETRFVLRSKDGKYRFKGSILKRIFDGYERVWKTERNVGDFPFEEGEIVKPVEVEIKELETKPKPRYTEGTLVKEMERLGIGRPSTYASTIKLLLSRKYVKKIRGYLYPTVIGSVVMDYLEKKYADIVDISFTAEMEKELDEVEQGKKTDKVVLQDFYRTFSKVFNENDRIIINYPTDQKCSCGKDMVLSFGRYGFYLKCECGKSRSVRNDEVAVIENGKMFIGRKNDEDSTSDGGNVKRKRSLTEKRRKGKKSS
(1506) Reverse gyrase [Thermotoga neapolitana DSM 4359]
6
MAVNLKYHHSCINCRGVNTDERNERGLPCEVCLPEESPSDIYEALLERRTLKDYRFYHRFWREYEDFRNFFKEMFGKNLTGYQRLWAKRTILGKSFTMVAPTGVGKTTFGMVASLWLARKGKKSALIFPTVTLVKQTLERLRNMSEDAKIIGFYSSMGKEEKKKFEESFEKDDYHILVVSTQFVSRHREELSRKKFDFVFVDDVDAVLKASRNIDTLLMMVGIPENVIKKALSAIKQGKIYERPDNLKTGILVVSSATARPRGIRPLLFRDLLNFTVGRLVSVSRNITHVRISRKSRERLVELLRVFRDGVLIFTQTEEEGRNLVDYLKGQGIRVEGTWERFEENFDAFKNGDIDVLVGVQAYYGKLTRGVDLPERIKYVIFWGVPSMKFPLELDRAPKFVLTRLLRESGLIKGREVNEEELRKLAKSHFSQEEFVERVKEIFRGSAVRGEELIIPDIYTYIQASGRSSRILNGVLVKGLAVIFEEDEEIFESLRTRLLLVAEEEILEESEVDWEKLIREVEESRKSLKKEFSDTSRSLLIVVESPTKADTISKFLGKSSSRRERNILVHEAVTDEGIILFTATRGHVYDLVTRGGIHGVEEKNGIFVPVYNSLKRCRSCGYQFTEDREECPICSSKDLDDKTETLRALREISLEVDEILVATDPDVEGEKISWDVTQYLIPANGSLKRIEMHEITKYGFKKARESVRFVDFNLVKAQVVRRIQDRWIGFELSGKLQKQFGKPNLSAGRVQSTVLGWIVDREEEYRKSEKNFTLITLENGAQLEVEGKVSVDAISVSKVEETEEDIAPPPPYTTSSALSEISQKLRLGVQETMDILQDLFEKGFITYHRTDSIRVSLEGQNVARSYLRKIGKEELFTGRSWSTEGAHEAIRPVKPIDDKEIEEMMEEGLITDLTKKHLRVYSLIFNRFLASQSSPVKVKRQSVFFDVEGKELKKEYVVEILKDGWNLFMPLTISPRFEHRSYRILERKIYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFKRGYVYEDKYRRIRPTKLGVMVYSFLKERYERFVTEETTRRLEEIMDRVEKGEEDYQSTLRLLYEEIKSLTEEG
(360) DNA topoisomerase 1 [Thermotoga lettingae TMO]
1
MANKIIIVESPAKAKTIKEILKGEYDVLSSKGHVRDLPEKEFGVNIEKDFEPTFKIIYGKEKIVQELKKKAKNKQVLLGSDMDREGEAIAWHLADILGVANEKNRIIFNEITPQAIKNAVKEPRNIDMNKVHAQLARRILDRIVGYKISPLLWKMLKTSSSAGRVQSAALKIVCEREIQRHKFQPKKFWKVQGYIGSLKFYLTHIDGKKIDMQQIDEKLAKEIEKNVKVLKVIQIKTRKIQKKAPSPFITSTLQQEAANKLGFSVKKTMQIAQQLYEGIDTPKGHRAFITYMRTDSTRVSEIAKQKAIEFITDKFGKNYLGKKVRTEKAKQNVQDAHEAIRPVNIDLTPDQVEGDLGKDQYRLYKLIWERFMASQMADAIYEETTIQFQSDRYTFESKIERRIFDGFEIILKKDKEQEITIPSGEIRISKWQIEEDETKPPARYTEASMVRALEIRGIGRPSTYATIISTLLERKYVIKSSNQLIPTVMGFVVNHYLEKKFPEIVDLQFTAKMEEALDKIEQGQKDYKELLRDFYNDFSKYLDEAQQKWLSIDMNTNLECDCKSKYKLKVGRYGLYLLCENCSKTTSLALETPAVFYENTMYFTHQEKESIETVCPVCGGKLEQMSGRYGNYIKCQNCGKTYTGFARGKCPKCSAVVEKKISKNKRIFFKCTSDNCDFISWLEPSNETCPECSQRLYYKKYRSKEVLYCQNCKKTFQLKTKK
(1745) DNA topoisomerase 1 [Thermotoga petrophila RKU-1]
1
MNRKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGIDLEKDFEPEFVVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGKKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKTNLSAGRVQSATLKLVCDREREILRFVPKKYHKITVKFDGLTAEIDVKEKKFFDSETLKEIKSIDELVVEEKEVSLKNFSPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKDEARNLITEVFGEDYVGAKGAKRKGNTKIQDAHEAIRPTNVFMTPEEAGKYLNPDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWTTERNTGEFPFEEGESVKPVVVEIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTVVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLQEFYQSFSSVFDRNDRIVIDFPTNQKCSCGKEMRLSFGKYGFYLKCECGSTRSVRNDEIAVIDDGKIFLGRKDSESGSPDGRSIKGKRNLPEKRRKGKKSS
(246) Reverse gyrase [Thermotoga petrophila RKU-1]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEESPSDIYGALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIIQGKSFTMVAPTGVGKTTFGMMTALWLAEKGRKSALIFPTVALVKQTLERLQKFSDGKVKILGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIKKAFSAIKQGRIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISTRSKEKLIELLEIFRDGILIFTQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKLNILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLEFDRAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLEMTIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEESETNWKELVHEVEESRKRIEGELTDTSKSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVVLFTATRGHVYDLVTRGGIHGVEEEDGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPATRSLRRIEMHEITRYGFKKARENVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEVEEERNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLKKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMVEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIATVELNGKRLGIEQIIEVLKNGWNLFVPLTVSPRFEHRNYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRLGVKVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(1141) DNA topoisomerase 1 [Thermotoga naphthophila RKU-10]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKNKFGVDLEKDFEPEFVVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGKKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKTNLSAGRVQSATLKLVCDREREILRFVPKKYHKITVKFDGLTAEIDVKEKKFFDSETLKEIKSIDELVVEEKEVSLKNFSPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKDEARNLITEVFGEDYVGAKGAKRKGNTKIQDAHEAIRPTNVFMTPEEAGKYLNPDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWTTERNTGEFPFEEGESVKPVVVEIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTVVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLQEFYQSFSSVFDRNDRIVIDFPTNQKCSCGKEMRLSFGKYGFYLKCECGSTRSVRNDEIAVIDDGKIFLGRKDSESGSPDGRSIKGKRNLPEKRRKG
(1233) Reverse gyrase [Thermotoga naphthophila RKU-10]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLLEESPSDIYRALLERKTLKEYRFYHDFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLAGKGKKSALIFPTVTLVKQTLERLQEFADEKVKILGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIKKAFSAIKQGRIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVERLVSVARNITHVRISTRSKEKLIELLEIFRDGILIFTQTEEEGKELYEYLRRFKFNVGETWSEFEKNFEDFKSGKLNVLIGVQAYYGKLTRGVDLPERIKYAIFWGTPSMRFSLELDRVPRFVLARVLKEMGLIKVQENPDVEGLRKMAKERLSQEEFVEKVKEIFRGAVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEESEANWKELIHEVEESRKRIEGELSDKSKSLLIIVESPTKAETISRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEEDGKFVPVYNSLKRCRDCGYQFTEDRNECPVCSSKNIDDKTETLSALREISLEVDEILVATDPDVEGEKISWDVTQYLLPATRSLRRIEMHEITRHGFKKARENVRFVDFDLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLLLENGVNLEVEGKITDDVVAVVELKEVEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLKKIGKEDIFTGRSWSTEGAHEAIRPVKPIDARELEEMLEEGLITDLTKKHLRVYELIFNRFLASQSAAVKVRKQIVTVDVDGNRVGIEQIIEVLKNGWDFFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFSQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDRYKRVRPTRLGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLMEEG
(1841) DNA topoisomerase 1 [Petrotoga mobilis SJ95]
1
MPKKSTKSKGNSEESKYVVIVESPSKAKTIERYLGKEYKVIASKGHIRDLPKKEFGVDIEHDFEPIFQVIPGKEKVIQEIKKETKGRKVLLASDMDREGEAIAWHLSQILDLDPKEKNRIIFSEITKNAIKNSISNPQSLDLKKVDAQIARRILDRLVGYKISPLVWKVLKDYKTSAGRVQSAALKLIVDKERKIFIFKPKKYFNIYLEYKGQNIPLTKEDGKKIKPESITKIKKDQIFEYLKDKDFKLVNVEEKESIRKPPLPFITSTLQQAAVSTFNWASSKVMKIAQELYEGVETSEGSIAFITYMRTDSTRVSNEAQQAAINYLEKNYGKDYVGHYLSKNKKSNVQDAHEAIRPTDINMDVNNAKRLISSDHLKLYTLIWNRFMASQSAPSRYLEKTYTIEDNTNKYAFEITSKKCIFDGFEKFWNPNNKEVNFEIGKNDKITYDQLKFEEKETNPPNRYTEATLIKELESKGIGRPSTYATIISTLLQRKYVSKIAKSTLRPTTTGFVVTDFLETYFPEIVDVKFTANMEEDLDKIEDGKNKSKVVLEQFYKEFETFLSTASNNIKNKKEILHYESDVPCEKCGKNMKLNFGRYGLYLSCEECKETQKIPAESFGVTIKEKLYIKEYLQETLKIDKEENKIDEKCPICGGDLILKHGKFGEFIACSNYPECKYTRNVKARGKCPNCGGDIVKLKSKKGKTYFKCNSCSTMYWNEPSEYSCPNCGETLFYKTSKGKEKLYREKDKAYFDIEEIKQLTK
(256) DNA topoisomerase 1 [Marinitoga piezophila KA3]
1
MPKTAKKIVIVESPAKAKTIEKYLGSEYKVVASKGHIRDLPQKKFGVDIEKDFEPEFELMPGKEKVVEDLKKIAKGKTVYLAPDMDREGEAIAWHLSYLLGLDENEENRIIFSEITKNTIQEAIKSPRKIDKNKVGAQLARRILDRIVGYKISPILWRILKDYNTSAGRVQSAALKILVDRERQIFKFKPKEFYKIFLKYMEQDIPLVKIDGKKFKKESISEKKKEEIFKELENAIYSVTAVTEKETKKNPPQPFITSTLQQSAISKYGWSSQKTMQIAQKLYEGIETKEGPIAFITYMRTDSTRISEDAMKKAHEYLESNFGKEYTGHFKVKKSKKKIQDAHEAIRPTDVFMDPKKAKELISGDALKLYTLIWNRFMASQSAPSKYIEKTYTISDNNKKYEFEAVGRKRIFDGFEKFWSSSTTEKEYEIPEKGILENIELKAERDETKPPSRYTEASLVKEMESKGIGRPSTYATIITTLLNRKYVIKEKNSLIPTLVGFVVSDILEMNFPEIVDVKFTAHMEENLDKVESGEMDWKTLLKEFYAEFEKFLNDTDKKLKERSMDFTYNTDISCEKCGEKMQLQFGRYGLYLKCPKCGENKGIQKGALGVTIDKKVYLDESFLKTEKGKEEGIGRQCPKCGGELVIKSGRFGKFIACSNYPECKYTEPLPARGKCPKCGGTVHKMKSKKGKVYYKCSECGEMFWDEPSDYRCPSCNGPLFYKRKNREEMLYCPEEKKYFKESEINEL
(1859) DNA topoisomerase 1 [Thermotoga sp. EMP]
1
MSKKVKKYIVVESPAKAKTIKSILGNEYEVFASMGHIIDLPKSKFGVDLEKDFEPEFAVIKGKEKVVEKLKDLAKKGELLIASDMDREGEAIAWHIARVTNTLGRKNRIVFSEITPRVIREAVKNPREIDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITVNFDGLTAEIDVKEKKFFDAETLKEIKSIDELVVEEKKVSVKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYEGVETKDGHIAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRERRKSNAKIQDAHEAIRPTNVFMTPEEAGKYLNSDQKKLYELIWKRFLASQMKPSQYEETRFVLRTKDGKYRFKGTVLKKIFDGYEKVWKTERNTGEFPFEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFDRNDRIVVDFPTNQKCSCGKEMRLSFGKYGFYLKCECGKTRSVRNDEIAVIDDGKIFLRRKDNESGTSDGRSVEGKGNLPEKRRKGKKGS
(550) Reverse gyrase [Thermotoga sp. EMP]
6
MAVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTLKEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAPTGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKIFGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVFVDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPGILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKLVELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFKVGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRFVLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVKDEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEKYVTEETTRRLEEIMDKVERGEKDYQATLRLLYEEIKSLMEEG
(1019) DNA topoisomerase 1 [Thermosipho africanus TCF52B]
1
MSKKKKVIIVESPAKAKTIEKILGDEYKVISSKGHVRDLPQKKFGVDLNNFEPEFEIIPGKENVIESIKKEIKGKEVLLASDMDREGEAIAWHLSQIFNLKGKNRIVFTEITPNTIKKSVETPREIDIKKVNAQLARRILDRIVGYKISPLLWKIIKGAMSAGRVQSAALKIICDRERERFLFKPKEFYKVSINVKKVKANLWSIKGKKIKQENITKEIAEDIKNNVKEVTLSDIVEKERKKSPPNPYITSTLQQDAATKLGFPVSKTMKIAQALYEGIDTKEGHLAFITYMRTDSTRVSEEAKQMAQEFIEKNFGKEYIGGSKNKKKTSKNVQDAHECIRPVNPEITPDIAKSLLSSDYYKLYKLIWERFMASQMKESKYKERTYIFQSEKYEFRTTYSHLIFDGFEKIYNSSSKEEEKIDLEKGKTYKVSKINIEKDTTKPPARFTEASLVKTLEAEGIGRPSTYATIISTLLARKYVKKENKELIPTLLGFTVEDFLTKRFPEIVDKKFTALMEEELDKVESGEKEWKEVLDNFYSEFSKYLSTAQKEFYTIDYETDLPCKDCKEENYKLKIGKYGLYLNCEKCKTNKSVDNTINAVLIENKMFIAQALENHENETVSENSCPKCGGHLLRKKGRYGYYFKCDNCDFTVSGYKIAQAKCPKCGSLVVMRRSKNGKTYWTCTNSDCDFMSWTEPKNEE
(103) Reverse gyrase [Thermosipho africanus TCF52B]
6
MPVNLKFDHSCINCEKINTDDRNLKGLPCIKCLPNETNDYINSLITTNKLYKLEKYIRFENEFKDFFNFFVEKTGLKLNGYQKLWTKRVLLSKSFTMIAPTGLGKTTFGILMAIWLAKKEKKSILIFPTITIVKQVVEKIKKLDKTIKVLYYNSNMKKSEKEDFEKRFKKDDYKILIVSTQFISKRKEELKNKFFDFVFIDDVDSVLKSSKNIETIIMLTGVPENIINETLKKLKSGQKPEIKDLKKGILVVSSATARPKGIRPLLFRYIFNFNLGKPSFFSRNIIHIRYKNKEINQLIELLKILNDGIIIYAENENEAKKLKEALKKNNIEAGTSWENFEESFEKFKNGKLNILIGISSYYGKLVRGIDLPEKIKAVIFWGIPKFRIEKEDLILPDIYTYVQATGRTSRLFKGNLLKGASFVFEENDEIFEKLSSRLFWITDEEFYNYNDIDIKKLANELNESRKNIQNKELEFSSKLIIVESPTKAETLAKFFGISSIRSLNGLISFESITKEGLITITATKGHTYDLITREGYHGVEFSNNTFIPIYNTIKKCKDCGYQFVDNYDKCPKCNSKNIDDKLSVLKALRELSLEVDEILIASDPDVEGEKIAYDILQYIYPVNSNIKRIELHEITRNAFLKGIDEKREIKENLVKSQIIRRIEDRWIGFELSQKLQTNFKRTLSAGRVQSTVLGWIIQREKEYKNSIKKFTSFTFENGLKVEFEGIHENATLKIENIYEDTIAPPAPFNTSTILSEISKKYKLSVNEIMSILQNLFENGFITYHRTDSTRISKTGQAVAEKYFKLINKPHLYKPKSYGNEGAHEGIRPVKPISPEELKDMIKEKIINLDKKHLLIYKEIFNRFLASQSKEIKVKKARLNIITENSKKSEEIITEILEDGWNIFMPIKVIQIMDENKVTDRKVYNKHTVPLFTQATIIEEMKSKNIGRPSTYAKIISVLFERKYIFEDKYKRIIPTKLGKIVYNFLNSKYNKFINEETTRTLEKIMDEVEKGIKEFQQTLHEIYNEIKGGIK
(874) DNA topoisomerase 1 [Thermosipho melanesiensis BI429]
1
MEKKKKVIIVESPAKAKTIEKILGKNFKVISSKGHVRDLPPKKFGVDLKTFEPEFEIIPGKEKVIEKIKKETEGKEVLIASDMDREGEAIAWHLSNILNLSGKNRIIFTEITPNTIKKSVENPREIDIKKVNAQLARRILDRIVGYKISPLLWKIIKGAMSAGRVQSAALKIICDRERKRFLFKPKEFYKVSIEIKKVKANLWGISGKKIKQENITEEIANDIKETVKEVILEKISEKERKKSSPLPYITSTLQQDAATKLGFPVSKTMQIAQALYEGVDTKEGHIAFITYMRTDSTRVSEEAKEMAKAFIEKKFGENYLGTTKKGKKKKKNVQDAHECIRPVNVEITPEIAQDLLNKDMYKLYKIIWKRFVASQMKEATYKDKTYIFKSGKYEFRTTISHRIFDGFEIIYPEKETTEKAVQLNEGEKYKVSKINVEKDATKPPSRFTEATLVKTLEAEGIGRPSTYATIISTLLQRKYVVKEKKELVPTLLGFVVEDFLTKKFPEIVDKKFTALMEEELDKIEEGEKKWKEVLNEFYSKFSKDLLNAQKEFYTINYETDLKCEECENTYKLKIGKYGLYLNCESCGKNKSIDNTLNAVIIKNNAYIQKAIEKNIKETVSENSCPKCGGHLTRKKGKFGYYFKCDNCDFTVSGYKIAAGRCPKCSSVVVMKRSKNNKIYWACSNPDCDYMSWNEPK
(1517) DNA topoisomerase 1 [Kosmotoga olearia TBF 19.5.1]
1
MSKKLVIVESPAKAKTIGRYLGKDYEVTSSKGHIRDLPESEFGVDLNSLTPTYRILKGKEKVVKQLKEKAKGKEVLLASDMDREGEAIAWHVAQILGLPKTKKNRIIFSEITENAIKRAVKNPRTIDMNKVNAQVARRILDRIVGYKLSPLLWKTVSRGLSAGRVQTVALKFISDLESKIAAFKPHKFYKIFMRVGEQKIQLLEINGKKFSNKSIRTEEERDKILNELKQSVFVVSSIETTRKKIKPPEPFITSTMQQTAINELGWSASKTMKVAQQLYEGIDTPEGHIAFITYMRTDSTRISEEAKEKAKVFILEKFGEKYLGTAKTKKSRKKNVQDAHEAIRPTYPERTPEEVKAKKLLSGDHLRLYALVWKRFFASQMAAAEYDVTTIKIADENGKYVFKYTTRNCVFDGFERILKKTNGNHETAIVPEGKTIKPDTFLWEEDQTKPPARYTEASLVRELEKKGIGRPSTYATIISTLLERKYVVKSGRELRPTLLGNIVADFLGKSFPDIINEKFTANMEEELDEIENAKRQWKEVVLRFYENFAQDLNKLEQDIKNGKLKIEYPTDRKCDCGGEFKVVFGRYGGYLKCSECGKNQSLDMTVFAPIIEGKVILHDIIETNNKKNELDETCPECGSKLVIRKGRYGSFIACSAYPKCTYTRDIYVDAKCPECGGSVKKMRSKKGKTYFKCVDCGKMFWREPAGKKCEVCGDPLFFKFKRRSKKVLYCEKCKKEFPINE
(328) Reverse gyrase [Thermotoga thermarum DSM 5069]
6
MPLAIYKEFCPNCGGEIEAERLEKGLACSKCIPDEISETELCEILARKSELKNYSWVCCLKSLERQFCDFFTKNLGFEPWALQRLWAKRVLSGESFTLIAPTGVGKTTFGIAMANFLPGKAYILLPTRLLVEQVAERCKTFKAKKVVAYTGKTSERKTIEAGDYEILVTTNMFLATNFELVQDQRFSFIFVDDVDSLLKSGKNIDRVLKLLGFTDEEISQAWQKVSGKLLEEKEEETMEEEEENILEESSQEDEFNEENVLQTKGKGILVVSSATLKPKTQRVKLFKSLLGFNVTPVKLTIRNVCDAVEWVDGPQQALYRLADWIRFFGKGGLVFVNREMGKDGVTTVVDFLKQQGINVSSYEELDLESMRNGLIDVAVGIATYNNALVRGVDLPEVIRYAIFIDSPKISFAIEQFDNPRNFVPLLLALREVVEDKSKIDLYLERLRRYQVFKFEKQLPKPLLEIAEYLRKNLNDESIVEKLEKAETIGLQRKEGKLFITFGDAANYLQASGRTSRLYPGGISRGISLILVWDKKAFHSLVQRLRLFYEEVDFLSADQVNWEEELKNVDADRKKIREIKKQFKPSEQLSLKSTLVIVESPNKARTISHFFGVPQQRILNGLHFWEILTGDRLLSITASIGHTVDLIEREEIYGVSKANGHFVPIYSTIKTCSKCGQQTTSEICSCGKQPDKDKLTLIKALQQVAPQFDEIIIATDPDMEGEKIGYDLMVALKPFNSNIVRAEFHEVTRQAFLKALNSPRELSKDLVKAQITRRILDRWVGFYLSQELWKAFKKYNLSAGRVQTPVLGWVIDRTNSARQKKAKLQISVKSILEGKTAALIYEHEDINFAKQLVSMLQQAQVTLEDVGQETENPPAPYNTASLLSEMGAFASAVDIMNTLQELFEQGLITYHRTTSTRVSQTGIKLAEEFLKQMGLHQIFHPRTYGTEGAHECIRPTKLLNVDDLKLWIHTGRVKFENQNLALQLYGRILNRFLASQSAPAVVQKSKLTIKLPDWSYEWTLTTKIIEPGFRTILPAKVFDLKPPLKVVWTTLRLVAKELPFTQGSLVQQMRERGLGRPSTYATIVQTLLDRKYVEERNGYLYATPLGYKVYHWLRTNYPQLTDESLTRKMEDVLDEIEAGNADYQSFLSEFYRDFLQKVFENKT
(492) DNA topoisomerase 1 [Thermotoga thermarum DSM 5069]
1
MSKKVIIVESPAKAHTIQEILNDEYEVLASKGHVRDLPEDEFGVNLKKDFEPKFEIIKGKEKTIQELKEKTKGKSVFLASDMDREGEAIAWHLSLLLGLKNGKNRIIFSEITPKAIREALKNPREIDMKKVEAQIARRILDRIVGYKISPLLWRALKANLSAGRVQSAALRLLCERELQRYKFEPKKFWRVEGYIGEIKFKLTHIDGKKIEMQDVNEKLAKQIEQAVVTLNVTRVSRRTIRKKSPDPFITSTLQQEAANKLGFSVSKTMQIAQQLYEGVETKEGHKAFITYMRTDSTRISDYARQQAEKYIKENFGEKYIGEVRQLKKTKNVQDAHEAIRPVDVYVTPERAKNLLQSDQYKLYKLIWDRFLASQMADAVYEETTIFLESGQYGFEAKVERPIFDGFELIYGKTASKNVKIPQGTVKVDRWEIVEDETKPPARYTEASMVRALEAKGIGRPSTYATIISTLLERKYVVKRGKELVPTVIGFVVNNYLQERFPSVVDLEFTARMEEELDKIEQGKKNYKEILRDFYNDFSDYLNKAQESWFSIDFKTNKLCECGESLTLRVGKYGLYLTCKKCSKSQSVRLDELAVLDKDTMYFYEENFEKKFCPSCGEQLKQVRGKYGVFQRCEKCGKTYGLFAEGECPKCGSAVERKTSKSNKVYYKCTNQDCDFISWLEPAKEKCPNCQNQLYYKVIGSRKRLFCANCNKTIWKRKS
(1844) DNA topoisomerase 1 [Fervidobacterium nodosum Rt17-B1]
1
MAKSETKKTTKSSSSNEKADKTKKKQSQSSSQIIDNSNVSKVIIVESPAKAKTIENILGKEYKVISSKGHIRDLPQRDFGVDLKSLDVVFEIIPGKEGVVEQIKNTVKGKEVLLASDPDREGEAIAWHLATILNINGKNRITFSEITPKAIQEAVKSPREIDMKKVNAQLARRVLDRIVGYKISPLLWKIIKDAKSAGRVQSAALKILCERERERIKFVPQKYYKVWIEIAGLKANLTKIGNKKLKPTDITKEIADDVLKNVKSVNLIDIDVKEVKKNPPLPFITSTLQQDASSKLGFPVAKTMKIAQELYEGIDTPEGHIAFITYMRTDSTRISDEAKEAAKELISKKFGEDYLGDEIRKTSKEKSKAKVQDAHECIRPVNVNLLPEEAQKLLDKDHYRLYELIWKRFIASQMSSAIYKQYSYDFKSGDYIFEASIRERIFDGFESVYSTDNEISEEHKELKIGESYDVLPKTAEAETTPPDRYSEASLVKILESEGIGRPSTYATIIQTLLNRKYIIRNRKTLIPTVLGFVVNDYLEKKFPDIVDKGFTAEMEKQLDEIENGTAQWKDVIKNFMKEFGRDLENAGKEFFTINFETNKICETCKEPYHLRVGKYGLYLNCQKCNTNKSVKIDELGVLLEGKMYFIEEKDEKTEDESDTTQDEANEKKSGYSSKKNYYRYKTSSRKSAKNQSKQTNKSKKSK
(548) Reverse gyrase [Fervidobacterium nodosum Rt17-B1]
6
MIEAIFKNLCPNCGGDITSERLLNGLLCEKCLPQQVSKEFLCEHIKEEKYDLCSLKERYNDWEKVFRKFIGFDPWELQKFWARKLLLGRSFALLAPTGIGKTSWGLATALYFSKKGKRSYIILPTKLLILQSYEKLKDKVKESDLLVFGLDESNKEREEKKKRLANGDFKILITSSMFLYKNVDLIPKDFAFIFVDDVDSFLKTAKNIDKALYLLGFDEKDISFTMNYIKMKRTQANEEKVKAMQEEVRKIASKAKGVMVVASATSDPKSERIRLFKELLSFDVGRPIFYLRNVEDVYEEVENLDDALVRTVKRLGKGGLVFLSSDFGKERVDYIKNLLESNGIKTETYENLSPEVLEKYRKGEIEVLIGISSYRNPLARGLDMPEVIRYAVFYGVPKIVVNLDIEGNVKHLLLALSSIRPLIARDKDLEEKVSLVDKWMKALKKFSSMPNPPVDKVNELKNEIKNFILSKEIHEKISNSDEVVLRQEDEKWILVVSDITGYLQASGRTSRLYVGGISKGLSYILVDDKKVLNNLLKKSRWWFSTDITFKEARSINIDEILRQIDEDREKVRRKEGRRDDFLKPVLVIVESPHKAWTIANFFGKPISRNVNGQELYEVITEDKYLVITASFGHVLDLNKEIGYFGVIEKEKFIPVYEPIDKKERMIEGIRDASKEFDMILVATDPDTEGEKISWDLKNLCTPFVKEIRRMEFHEITKKAILNALKESRNVNENLVKAQVVRRISDRWVGFELSQLIQKVFSKSSLSAGRVQTPVLGWVIERAKENRKKIHIVSVKRYGLDIKFEFEDKQKAQKFYNGLKYIQINKSSEKIQEKSPLPPYTTDALLKDASEKYKISVSRTMEILQELFERGFITYHRTDSTRVSDVGISVAKSYIAEQFGEEYFKGRTWGEGGAHECIRPTRVLDVEDIKSMIYSGELEDFTPDHLKIYDLIFKRFISSQMRNVVVKSCDITVKAFDKEQTFEIYEEIIQEGYNKIFPIKLTKIPTGEVVVVNYKSFYSVPKVPLFTQGTLVEEMKKRGLGRPSTYATIVSRLLERGYVVEKEGYLIPTPLGEKVYKFLNSSPEKFKFVREDFTRELEQLMDKVELGEEDYQKILKNLKMEIERI
Family distribution
Taxonomy tree
Thermotogales