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Taxon : Deltaproteobacteria
Informations
Name
Deltaproteobacteria
Rank
class
# topoisomerases
47
Lineage and sub-taxa
Lineage
Bacteria
>
Proteobacteria
>
delta/epsilon subdivisions
>
Deltaproteobacteria
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(1605) DNA topoisomerase 1 [Geobacter sulfurreducens PCA]
1
MSQHLVIVESPAKAKTIEKFLGPDYKVLASYGHVRALPSKQGSVDVEHDFEPRYAVLPESKRHIDAIKKELKASDSLLLATDPDREGEAISWHLLAALGVKPEKPPVPVRRVVFHEITKDAIVHAVENPRDISQDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFQSQEYWTIGAELAKEGGQKCTANLVEAEGKKLDKFDIPDQAAADRLVKALENATFTVDKVTKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMATAQKLYEGVAIDEGLVGLITYMRTDSVVLSNQALQEAHQVITSLYGPEYALAKPRFYKNKAKNAQEAHEAVRPTSIARTPAELKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGKGYRFRAAGTVIRFPGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLLKLLPEQHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLLERKYARLDSKRFIPEDVGMVVNDLLTNHFTTYVDYNFTATLEEELDQVSRGEKRWKPLLREFWEPFQGLLKQKEGEVSKADLTTEATDEACPECGKPLVVKLGKRGKFIACSGYKEGCTYTRNIDQGEGREQAEPVLSEEKCDKCGSPMLIKDGRFGKYLACSAYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPGPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
(564) DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family [Myxococcus xanthus DK 1622]
7
MLAEKPSVARDIARVLGANERGEGWLRGNGYVVTWAIGHLVGLAQPHEIRADWKKWSRALLPMLPADWPLVVSKETRSQFEVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKCRKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSRADWLVGMNLSRLYTLAHGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALYKGTWFRSGPDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMAPPLLYDLTELQRHANRLHGFSAQRTLEVAQALYEKHKLLSYPRTASRHLSRTVADTLPEVVNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVRLSPDEQRVYDLVCRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPRLKSEGRKGEDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAMESAGRALDEKELADAMRETGLGTPATRAAIIEVLLDREYLRRRGKVMEATEKGIHLIQVVHPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAPQRPPRNEVLGAPPGAGWGQGGAAQVASEGAAAAHGAGAGARGPGGQGAFAESSAERFGDASAGGAGRGRQGAFTEASAERFADAAPGVQGQGRPGALSEASEPLFGTRRSRTSGSVGRSEPHGEPLSSTMSPGGGAASRLPRADGTGWNAGAWENTGAARAPVNRARTPASAASTGQRPERVRRAPTAPEALRPLLKEAFGFSDFRPYQEAVCRAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQVARLQSLGFAADRIHSGRDRAMSRQVCADYLEDRLDFLFIAPERLGVPGFVEFLARRTPALIAVDEAHCISQWGHDFRPDYRLLGARLPLLRPAPVVALTATATPDVQRDIVQQLGLQGPGGKARTFIHGFRRTNIAIEVRELNPGARGDAIQGLLEDEENRPAIVYAATRKHAEQLADQLAGEFPAAAYHAGLQPSERDRVQAEFLRGSLEVIVATTAFGMGIDKADVRTVIHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYIDRRTHEFFHRRDYPEAYVLERLFKSTAPQLEPKAVLQGRVRGDPEVFDKALEQLWIHGGVVMTPDETVMRGKPGWSASYSAQRDRKLLHLEQMGRYAEAHGCRMKQLVGHFGDTQDSGEPCGLCDVCAPEDCATLRFAEPTSAERHWLERILESLQERDGQATGRLHRELFGESLPRRDFERLVGGLVRAGLTRLEVDSFDKDGQVISFQRLALTDEGRRTRAVDPQRVVLPLPLEKAAKRKRGKGAEKGTAKRATAKKRTVRAKAGAATRRTASESDEEDSPTHWRANAPSKSTAGAPRASRSTGAPSGSASGRRAAAEPSPKMVEALKAWRLAEARKRRVPAFRILTDRVLEAIASACPENGSELMAIHGVGPSLTERYGAQILSLVARRS
(996) DNA topoisomerase 1 [Myxococcus xanthus DK 1622]
1
MGIERGTGMADAETDILTAEQQACLALWAVPGLGPRTLVALRAFADGSLAPLAATPVRDWVSQAPVSSQVRRKLASVERLAPVAWRVWEACRASGMKVAFQGQAAYPERLAEVEDAPPVLFYRGVPGLPRRRLAMVGSRHPDQGFLPFARRFARQVAASGVGVVSGAASGVDRACHWGALDEGGETWAFLGSALDALDTAQARLLPHFLDRGGVFFSELPPGVRASTTTFPRRNRLISGASDAVLVLRAGKDSGSLYTAEAGRAQGRPVFAMPGDVRQEEAAGCNALLRNGEAAVCLGPDDVWRVLKVDPLAAVPPGTMGSWEDLSAEAKGGLRDVGPGSPELRRGAGRQHLLTGGARQRAGGVGIDGAGHPAPRKAVRENLGRRVMATRTKKKVEETEAAEEKAPAKKAAAKKAAKKKPAAKKKTAAKKTAARRRTKKGDEDELPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREGEAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQISPLLWKKVRRGLSAGRVQSVAVRLIVEREDEIKAFVPEEYWTLDALLEGPAGPPPFKAKLSKLDGKKVELKERVFTESLVAELQTASFSVAKVDRRERRRNAPAPFITSKLQQEAANRLSFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFLPDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKPFFEAMGEEDMYRLYELIWKRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEGADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVMVEEETTDEVCEKCTKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRDGPYVACPNKECDYRREITEQPGGPGGSPEASSAA
(54) DNA topoisomerase 1 [Desulfarculus baarsii DSM 2075]
1
MPKNLLIVESPAKARTIGKYLGPDFIVKASVGHIVDLPPSELGVDLENGFQPHYRVIKGKDKVIKELRAAAAKAGEIFLAPDPDREGEAIAMHIAQQLGRPLESYHRVLFHELTKSAIAKAVAAPAKIDVDRYNSQQARRVLDRLVGYQISPLLWDKVKRGLSAGRVQSVSLRLVVERERAIQAFEPQEYWTVTAMLQGQQPPPFAARLARLAGKKFDPKNEKEAMAGVTAIQGQRFVVEKLTKRQRKQQPAPPFITSTLQQEAYRKLGFAPKYTMGLAQALYEGKQTSEGQMGLITYMRTDSTRLAAEAVATVRALIAARYGQEYLPAKPNAYKSKANAQEAHEAIRPTNAALTPELLEAYLSRDELRLYQLIWNRFVACQMAPAVYDQTQAEIVAGQGLLRASGQVLRFRGFTAVYVEDRDEHGGDEARASAEAKDHDQALPPLPPLDEGQELALQGVEPKQHFTQPPPRFTEASLVRELEEQGIGRPSTYAAILSTIQEKDYVSKDQKRRLIPTELGYLVNDLLVECFPQIMEVGFTAQLEGLLDQVEEGRQDWRGLLADFYGPFQQALGAAKTHMRQIKGKGVETDVKCPLCGKPMAIRLGRNGEFLACSGYPECKSTSDFSRDEKGAIVLQEAAPDPGVACDKCGAAMVVKKGRFGPFLACSAYPQCKNIMALGADGKPVAKPQPEATGEKCPKCGGELVIKPTRSGGRFISCANYPKCNYSKGLSTGVKCPKCGGELVEKRSRRGKPFYGCDNFPTCDYASWDRPIDEPCPQCGHPFLVEKVGKKETVVRCPQPDCNFKK
(1209) DNA topoisomerase [Sorangium cellulosum So ce56]
7
MIAVVAEKPAVARDIAAVLGASKRAEGFLEGGGYVVTWAIGHLVAIAEPHQIDPAWKRWRLDLLPMLPGQFPLVVLPGTRAQFEIVRKVLGRRDVERVVCATDAGREGELIFRYIYEAAGCKKPVERLWISSLTPDAIRDGLRRLRDARGYDGLADAARGRSRADWLVGMNLSRAYSLVFDQDLSVGRVQTPTLSMVVERELAIRRFVPEPYLEVVATFCPLREDASGAADESYKGTYFNDKPVPGEPPGAGERPNAGERPNAGERPNAGERPNAGERPNAGERPETAPSRRRLPPDGEEARRIIERARRGEARIEAVRSESRRLPPPLLYDLTELQRHANRLYGFSAQKTLEVAQALYERRKLISYPRTDSRHLSTEVAATLGAAVQAIEGSYRGMLAPGTGARPLGKRFVDDGKVGDHHAIIPTGARSSRAELSTDEQKIFDLICRRLLSAWHEDHVTSITTVITAITTRGGAGARGGEPIVDRYHSAGSVVEKVGWKVLDIGFGKPPARPRRKGESDGDGPDAPDARDGEGGEGERETADQRLPPGLARGQVQLVLDAEAQAKKTRPPPRFTEATLLTAMETAGSSLEEKELSAAMKDSGLGTPATRAAIIETLLRREYIVRKGKLLHATDKGVGLIEVVHADVKSPAMTGAWEAKLARMARGGGDLPSFMAGIESYVRQVVAEVSAGRRAAGGGALSPEAGASPFQERGEARSRAKGDRAAAAAPGTGRGREATPRRAPGSSAGAVPGDASAGTLQAVAAAAAASPPARAQARSRAAAPSPARPAAATARRVAVAPSTARPVAATSPPARSAAIAPSLARPAAATSPPARPAAVAPPPARAAAIGSFPARGAGTASSPAVASSPARRPEDLVELLHQCFGFSAFRPYQEAVCRTAAAGSDVLLVMPTGAGKSLCYQLPGIARGGTTLVVSPLIALMEDQASKLRACGFAAERIHSGRSRAESRKACIDYLEGALDFLFIAPERLRVPGFPELLARRKPVLVAVDEAHCISKWGHDFRPDYRMLGQRLPALRPAPVIALTATATPVVQDDIVEQLGLASAARFIHGFRRSNLGIEILEVSPGERLARVRALLGQEGRTPAIVYAGTRKDAEALAAGLSEDLPAEAYHAGLAAPVRDRIQAAFLDGSTEIIVATIAFGMGIDKPDVRTVVHAGLPGSVEGYYQEIGRAGRDGLPSRAVLMHSYVDRRMHEFFHERDYPDPAMLQRIEEVLSEEPRPKEAILGDLGIDPEVADKALEKLWIHGGARVDPDGGIALGEPGWRGPYEAQRRHKLAELVQMARFTEGHGCRMLHLVRHFGDQEDTGEPCGLCDVCAPAACAAREFRAPSRDEAQAIAKILAALRESEQPTGRLYREAFADGSLERRDFEHLLGGLVRAGLVCVREDSFEKAGELITYQRASLTSRGLLGGPRGASDVVGDVPLAKLPPKVKKRQSATSSDARRAFFARKAQRKKGRSR
(742) DNA topoisomerase 1 [Sorangium cellulosum So ce56]
1
MAKTLVIVESPAKAKTIKKYLGNGYEVFASKGHVKDLPKKQNAVDVQNDFAETYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIAFHISEEIKNPKLKVARVEFHEITKKGVDHGVHNPRKLDENLYDAQRARRVLDRIVGYDVSALVWSKLAFGLSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAKLASADGKKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQDATNYLHFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVVAKRYGKEFVPERPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLYKLIWNRFVASQMTPAVYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQEFAGEEESAGAAADGGAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPPGVITDQKFTQPPPRYNEGSLVRELEKRGIGRPSTYAEIISKVQQRAYVEKRDGGAFQPTLLGKFVVDGLVRSNLDIMDPNFTAQMEEELDAVGAGSLKREQLLKSFYKKFREQLDKSKKLAPWKPEAEKTDIVCDECGSMMLKKWGKNGWFLSCERYPKCKATRDLSDARGTAAVRETDISCDKCGKPMIIKTGRFGDFLSCTGYPACKNTRPVPLGVACPSCGGDLIEIRPRKKGGRTFYGCSNWNAEQKCEFKLWQKPVPVPCPQCGAKFVTRTAGKKAMLVCATKDCGFKQEIVEGEGEDGAADGAATPDAAAVVASAAPAPAARPAPAEPTPAGRPEAAPEGAGAAQGAAEKPARAVRARRTAS
(1758) DNA topoisomerase 1 [Haliangium ochraceum DSM 14365]
1
MADQQAISKKRANDPANQADAADDNTSAKGATSEKSASKKAASPSKKTSTKKASTKKTAKKASTKKASTKKTTKKASAKKASAKKTAKKASAKKTTKKASAKKASAKKSASQEAAEDEGESAPKRTKSRSKATKQGKALVVVESPAKARTIGKYLGPDYTVKASVGHIKDLPKNKIGVDVDQAFEPEYVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAWHIAEEIKPINDNIKRILINEITKKGVNHAIANPTVLDTNKTDAQQARRILDRLVGYEISPILWKKVRRGLSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHRWDGAKAEPKTEAQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEASRKLRFSAKRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQGTYGPEFLPAKPHTYKSPKRAQDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYTLIWQRFVASQMAPAVYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAADQDKLLPHLEEGMAIHFDAIRPEQHFTQPPPRFTEASLVKELEERGIGRPSTYASIISTITDRGYVERREARFFPTELGAIVNDLLVESFPKIMDVDFTAAMEADLDKVEEGERDWRELLGGFYEPFRGNIEHAKENMRDVKREEIPTDHVCEKCGAPMVIKWGRNGSFLACQAYPDCRNTKEINRNPDGSFEIVPEQTTDETCSECGAPMVVKRGRFGAFLACSTYPECKNTQPISLGVDCPKDGCGGFLTEKRSRRGKPFYGCSNYSKTGCDFVTWDRPIAEACPVCEASFLVKKETRRGTTVRCLSCDYKTEQAGESAA
(993) DNA topoisomerase [Haliangium ochraceum DSM 14365]
7
MTATTLIIAEKPSMARDIARVVGARSKREGYLEGGGYWVSWCIGHLAELCEPHEYDAKWKSWSPSLLPILPDELRVRPSRSGAAHLRVLHRLMRAREVGTIVNACDAGREGELIFRHVHALSNTRKPVRRLWISSLTGEAIRRGMSALRPGAEFDDLADAARARADADWLVGMNATRALTGLVRSGGTRGLLMSVGRVQTPTLALIVRREREIESFESKPFWQVLATFAVPGEAGASYEGIWQRPREAGDDAGDAQRDNKGDAQRDNKGDGDTNTARDRSRVPTRQQADAIADAVRGRAGTITQLTRKSTRERPPLLFDLTNLQKLANRRFRMSAKRTLELAQALYETHKLITYPRTDARYLTDDLAPTLPELVRALAGEYPGLRDTALAGAAHAAGNRRIFDNAQVGDHHAIIPTAKAPSPGRLSADERRLYDLIARRFLASLFPDAVYDQTKIVTTVAGHCFATERRVCAEPGWQQAEPPPPAKRNEPPLPRLRQDMEVDTAAIEVREGKTQPPKRYSEASLLGAMEHAGRSLDDPGLRRVMRDAGLGTPATRAAIIETLLKRSYIERQGRELVPTEQGRALIASVPIEDLLSAELTADWEQKLDAIARGRASKARFMDEIHGYVRRIVDALAQATPPSLPSPTDEVLGLCPVCNGVVTEGFKTFQCASGKSCSFVIFKRIAGRKTSAALVRVLLARGRTQTLKGFRSKRGKRFSAVLTLDAEGKVQFAFDNPRGGATKSAGSAKGAKKSASSASGAKKSAASASGAKSAAAGGSGPRCPACRQGRIITGRRAWGCSRWREGCGFTVGFQQGEVRVSEEQAERLFRRGQTVLLDGLMPERRARLVLDLEAEGNVRVEPGKRARRT
(670) DNA topoisomerase III [Stigmatella aurantiaca DW4/3-1]
7
MGTAPEQEKTRQAGGGVAPRGPSSVLAVVAEKPAVARDIARALGATQRGEGWFRGNGYVVTWAIGHLVGLAQPHEMHPAWKRWHREQLPMLPSTWPLVVSENTRTQFEVVRAVVNAPEVSGVVCATDAGREGELIFRYIYEAAGCRKPVKRLWVSSLTEGAIREGFRTLKDGRAYDALADAAKGRSRADWLVGMNLSRLYTLACGETLSVGRVQTPTLAMLVERELAIRDFVPEDYLEVVATFAPQAAGVPAGTQYRGTWFREAEPKGGPRTAETAREARRLPADGVEAGEVMARVRSGAAVIESLTSETKRMAPPLLYDLTELQRHANRLYGFSAQRTLELAQNLYEKHKLLSYPRTASRHLSSAVAETLPEVVRAIRAPYEPLLAPGTGEKPLGRRFVDDAKVTDHHAIIPTATSPEGERLPPDEKRLYELVCRRLLAAWHDEHVWAVTTVVTAVSSVGPAPGSPRVDRFHSSGTQVVRVGWKVLDIGGGQRPPKGREGKGPKEEGEGKEPEDEPQDLPAVLARGQKQRVEDVEAVKKRTRPPPRLTDASLLTAMETAGRTLDEKELADAMKETGLGTPATRAAIIEVLLEREYLQRRGKSLEVTEKGIRLIQVVHPDVKTPAMTGQWEAWLQRIERGQGDLQAFLRGIEAYVIEVVGKMPAQPMPPRAEGPRPPPPSGAPASGAPPASVPAVSVAARAPLSAPRPASPSPSSPAAMRVRVEAPQGASKRSVERTPRAPTPPGELRKLLKEAFGFEDFRPYQEEVCKAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQVTRLQSLGFAAERIHSGRDRAASRQVCTDYLEGRLDFLFIAPERLGVPGFVELLARRPPALIAIDEAHCISQWGHDFRPDYRLLGARLPLLRPSPVVALTATATPDVQRDIVQQLGLRGSRGGASRTFIHGFRRTNIAIEVRELNPGQRGDAIRDVLAEPENRPAIVYASTRKHAEQLAERLAEEVPTAVYHAGMTPADRDRVQSAFLSGRLEVIVATTAFGMGIDKADVRTVVHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYVDRRTHEFFHQRDYPEPSMLAKLFHAAGAGLEPKEALQARVRMDPEVFDKALEQLWIHGGLEMTPDENVRRGRPEWPAPYTAQRERKMLHLEQMGRYAEASGCRMRHLVSHFGDVQDSGKPCGLCDVCAPETCVTLRFAEPGERELQALGRILDALHERDGQATGRLHRELFGEALPRREFERLIGGMVRAGLTRLSEDSFEKDGQSISFQRLTLTPEGQRTRVIEPDLVMLPMPLEAKSAKKRRATRGKAAGARLEKPRRAGTRGPPVGHSAGSASEGRQRPVAVPWGGTRERAGAVTGRSSKALSVVREWEGMDAPPATEEDWDEEQDIGVRRGGRRQPMPLPKPSPALVEALKAWRLAEARKRRVPAFRILTDRVLGAIAAARPEDREALMAIQGVGPKLVERYGAQLLALVGR
(1289) DNA topoisomerase 1 [Stigmatella aurantiaca DW4/3-1]
1
MATRKKKADETGTEAEETAAKKKAKRPAAKKAAAKKKSATKRKGSASLATVEVSADEEEEATPRGKGPHYLVVVESPAKAKTIKKYLGTGYTVKASVGHVKDLPKSKIGVDVEHDFQPEYQVIKGKEKVLNELKKAAKAVDKVYLATDPDREGEAIAWHIFEELGHKDSYRVLFNEITKKAIQEAIAQPRHLNQESYDSQQTRRILDRLVGYQISPLLWKKIRRGLSAGRVQSVAVRLICEREDEIKAFLPQEYWTLDALLEGASGPPPFKAKLSKIDGKKVELKDRETTDALVAELQGAEFTVAKVDRRERRRNAPAPFITSKLQQEAANRLHFTAKKTMTLAQRLYEGIPMGEEGQTALITYMRTDSTRLSDDAVKQVREFIGNQYGGDFLPEEPVSYRSKKNAQDAHEAIRPVSLEYPPERVRPFFEQMGEQDMFRLYELIWNRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLRVYGAGLTPEEEAEKEKAKAAGDEATDSDEATGELPPLNDGDKLRLQKLLNEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGVMTNEMLVKHFPKEMAVAFTADLEEKLDQISEGGASWKAVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNPLVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVIVEEETTDEKCENCGKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVNCPECKQGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEACPQCQSPYLLQKFSKRDGVYVACPNKECDYRREVQQPADATAPSAA
(1415) DNA topoisomerase 1 [Anaeromyxobacter dehalogenans 2CP-C]
1
MAKEPKTGAVAVKKKKAAAAPKEATAVAEAEAPKTPRRAARKTSTGTSLVVVESPAKAKTIKKYLGRAYDVKASVGHVKDLPKSKIGVDVEKGFLPEYDVIKGKAKVLSEIKRAARTADHVFLATDPDREGEAIAWHISEELGSEGGDARVRRVLFNEITKTAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFVPVEYWSLDADLAAQVPPDFRAKIFKVDGQKADLKQGEETLALVKELEGARYVVASVDRKERKRNPPPPFTTAKLQQEAANRLGFSPKKTMTLAQRLYEGVELGDEGAIGLITYMRTDSVRLATEAVDAVRAHIQQAYGKDHLPEQANVYKTKAKAAQEAHEAVRPTSLEWTPDRVAPFFDQMGERDMYRLYELIWNRFVACQMVPAVYDQTAADIAAGRAVFRATGSILKFPGYLAVYGAKPPEEEAGAEEEKSNGDAAEPAARAEDRQLPPLEAGMELRLLKLLPEQHFTQPPPRFNESSLVKEMEERGIGRPSTYAAILDTIQEKGYVEKLEKQFKPTHLGVLVTDELVRAFPREMDIAFTASMEEKLDEIEEGSAGWQRVLEEFYVSFKEDLAKADEAMRNVKAQAIETDITCEKCGQHKMVIKWGRNGEFLACPGYPECRNTMNFRREDGNIVPEKEEDVPVEDKCPECGADMVMKRGRFGRFLACTRYPDCKGTKPVSIGVTCPKGCGGYISEKRSRRGKTFYGCSSYPKCDFVAWDRPRNETCPQCGSAYLLDKYSKKTGPFVACPNKECGYRREAEPREGGAAAAQVEPAKA
(1144) DNA topoisomerase 1 [Anaeromyxobacter sp. Fw109-5]
1
MPRATKAAAAAEGVKAEGVKKEKAAPPKRAAKKVAQGGSLVIVESPAKAKTIKKYLGRSYDVRASVGHVKDLPKSKIGVDVEAGFTPQYDVIKGKAKVLSEIKRAARSAERVYLATDPDREGEAIAFHIAEELGDSGDGRVRRVLFNEITKNAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFKPEEYWTLEAELAAKLPPEFRARLSKVDGQKAELKEGAVTHALVKDLDGATYVVATVDKKERRRNAPPPFTTAKLQQEAANRLGFTAKKTMTLAQKLYEGVELGDEGAVGLITYMRTDSVRLSTEAVDAARGYIAEAYGQDHLPEAPNVYKTKAKAAQEAHEAVRPTSLEWTPARVAPFFEQIGERDMYRLYELIWNRFVACQMVPAVYDQTTADITAGRATFRATGSILKFPGYLAVYGAKPPEDEAGAEEEAKENGDREKANEERQLPPLEAGMILDLRRLLPEQHFTQPPPRFNESSLVKELEQRGIGRPSTYAAILENIQEKGYVEKVERNFKPTHLGLVVTDELVKSFPREMDLAFTAGMEERLDEIEEGNAAWQQVLKDFYDSFKDDLAKAEVNMRDVKRQEIATELTCEKCGKPMVIKWGRMGEFLACSGYPECRNTMNFKRGEDGTIVPEKEEDVPTDEKCPECGAAMVMKRGRFGRFLACTRYPECKGTKPVSIGVSCPKGCGGYISEKRSRRGKTFYGCSSYPGCDFVSWDRPRNEACPQCGSAYLLDKYSKKTGPYVACPNKECGYRRDAEAKAPGAASEA
(1736) DNA topoisomerase 1 [Desulfovibrio africanus str. Walvis Bay]
1
MAKNLIIVESPAKVKTIKKFLGRDYMVEASVGHVRDLPPNKIGVDEERGFTPDYKVIPGKQKVVAKLKAAADQAEHIYLAPDPDREGEAIAWHVAHLIGDKNKQVSRIQFNEITSRAVKEALDNPRPLDENLFHSQQARRILDRLVGYKLSPLLWSKVKRGISAGRVQSVALRIIVDRERERQAFRPEEYWVFKALLEGPEPPAFAAELWKVEGKKPSVGSGEQAQVLYDRVKDTPFVVSAIEEKERQRHPSPPFITSTLQQDASRRLGYTAKRTMSTAQRLYEGVELGESGVTALITYMRTDSVRVADEARDAAQAFIVETLGADYYPPKPRYFKTKSGAQDAHEAIRPVDVRVTPESVRKHLPADQYKLYTLIWQRFMASQMAAARLHDTTVTVDSGPAQWRAKGERVLFPGFLKVYGVDEATDEKTEGEGGESTSTKAAMLPKLEKGMQLTVRKLTKDQKFTQPPPRYTEASLVKELEEQGIGRPSTYAAIISTLLDRDYARLEEKKFVPSELGVTVVDLLTKHFQSLMDVHFTAGMEEQLDDVAGGKVNWVELLKHFTGDFYPTLDKAKDEMVQVKGGLETGIVCDLCGKPMNIRFGKNGEFLGCSGYPDCKGIKNFTRDEQGQIQIVERANEMPEKVGTCPDCGKDLVLKRSRTGSRFIACSGYPECKHAEPHSTGVTCPREGCTGQLVEKSSKRGKVFYSCSTYPKCNYATWDWPIAKPCPQCDSKILTIKTTKARGEHVACPEKACRFTRELEPDESVG
(262) DNA topoisomerase type IA central domain protein [Desulfovibrio salexigens DSM 2638]
3
MRLFIAEKRDVALAISQALGGPDRPTGAAFQVNGDRITWLWGHVLRLTDPEEHDERYKLWDLNTLPMKWPVTYAPESKHVDHLKKIIELAHQADELVNAGDPDPEGQRLVDEVIEFAGLLEKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAVCDQRYGYNLTRCYSTLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQIDMPSQLVEAEYIPADDAPVDEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPLPYNLLALQADAAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQALTPAFGDMAEYAAPNLKSKAFNSKKVTAHHAIIPTMNVPELGKLNEDERRIYTLIVKLYIAQFYLPAEFVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHKLQQNDSGTVESAESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDESGGIGTPATRDSHIETLFRRGFVAEKSKKVISTELGREFHDALPEFAVKPDMTALWHEKQKQIEAGELNYLQLIEEVDGSVAQEIARVKREGINIKSSAVQCPKCKTGFLKPRKGPKGKFWGCSAYPDCNATFPNKAGKPDLKAKPAKKLAASKEHKCPDCGKGLIRRPAKRKGLFWWSCSGFPECKFRCFDEKGKPKLES
(1384) DNA topoisomerase 1 [Desulfovibrio salexigens DSM 2638]
1
MSKDLIVVESPAKVKTISKFLGRNYQVAASVGHVRDLPKNKLGVEENGDFTPQYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIGWHVAAIIKEVNENVSRIQFNEITARAVKEALEHPQPLNEQLFDSQQARRILDRLVGYKISPILWKKVKRGISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWKVDGKKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDANRRLGYSAKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVILDKYGDEFYPAKPQVYKSKGGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNRFIASQMAPARFWDTVVTIQAKNTIWRSKGERLLFPGFMRVTGKTGDEKLIELPKLEKGEVLKVDKIESEQKFTQPPARYSEASLVRELEEKGIGRPSTYASIISTIQDRGYVNLEEKKFIPTELGFVVSDQLSEHFKELMDVGFTAAMEKQLDDVADGKIEWTSLMKDFVDGFYPTLETAAKEMKRGGEDTGITCDKCESPMVIKFGRTGEFLGCSNYPECKNIVNFTRDEKGKIVVLEEEPPEETGVTCEKCGSAMAIKRSNRGEFLGCTGYPDCRNIKNFERDDEGKIKVVETPTAQIVGKCPDCDDGDLIIKHARTGSRFIACSNYPDCKHAKPFSTGVKCPREGCKGELVEKSSRRGKLFYSCDQYPDCDYAVWYPPIDGPCPKCGHPVLVKKTTRAKGEHIACPEKGCGYVQGEEES
(24) DNA topoisomerase 1 [Desulfurivibrio alkaliphilus AHT2]
1
MGKSLIIVESPAKARTLQKHLGKDYLVKASVGHIRDLPVSSLGVDIDHDFAPQYVTIKGKAKVISDLKKAAKEADQVYLAPDPDREGEAIAYHIAEALKTTRKPIRRVLFHELTHKAVLAALEKSGEVDHHLFEAQQARRVLDRLVGYQISPLLWDKVRRGLSAGRVQSVAVRMVCEREEEIEKFVSEEYWSITTTLAGPQPPPFQALLEKVDGRKLDNRKRKIADEAQARELVLQLMAAELKVAGVDKKQQRRRPSPPFITSTMQMDANRKLRFSAKKTMAQAQRLYEGIDLGKEGPVGLITYMRTDSTRVNDEALGMARDYIGSTYGADYLPAKPVQYKTGKGAQDAHEAIRPTDVSRTPESLAGKLDKDMLALYTLIWKRFVASQMAPAIYDQTSIRIAGGPEGRHELKATGSIMRFPGFMTLYVEAVDETPEEGKQSGKGGKDALLPDLQEGQLLKLNEITPKQHFTQPPPRYTEATLVKALEENGVGRPSTYAAILSTIVDKEYVRLTQRKFYPTDLGRMVNKLLVAHFPKVIDTDFTAKLEQELDEIETGKVDWVQVMREFYGPFQQNLEQAREEMKAVKHSAIPTGLNCPQCESELVIKWGRKGEFLACSNYPECKHTQDFTRDEEGKIKPLEREAPEESGESCDKCGKPMVYKHGRFGKFLACSGYPDCKNVRAISTGVSCPEDGCDGEIVQKVSKRGKVFYSCNRYPKCTYALWDKPVAKPCPLCSSPFLVEKSSKKGRRLACPNKECRYSEELPEEGE
(1362) DNA topoisomerase [Desulfovibrio alaskensis G20]
7
MSKILIIAEKPSVAREIAPLVGAVSRRDGFLEGPTHIVSWAVGHLVNIAEPEEQDEAWGGRWALEQLPMIPRQFRLTVLPEARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRIQLHAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLAAFARAEADWLIGMNLSRLFTLKAGSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGGAAAAAGSAAPVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDVFSAVWHLPPDFKETRLERQDDAEAVIGRCQGGTGVVDATENRKGSQKPPLPFDLTTLQREANSRFGYSAKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHFRAVYHLYPQETVPAVERVKAGCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAPASFMSSTVRVLSGEDVFVARGKVFKDIGWLAVEPWRTAEDNPLPALRKGTRLHVHEVSAVRRQTKAPAHFTDASLLAAMETAGRLVDDEELRNAMKERGLGTPATRAQIIETLLARGYVEKKGKRLIATDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNTYPLFMQEIRTMLAQSVESIKPRNVKNILVETAARLASRELDGKCPLCGAEVEERDKGFGCSRWKRADGGCPFMIWRTFMGTQIDAGMVRELLETGCTSQELQLTSRGGNTFSARLRLEQGRVRPDLPEKHARASGGAAPSAGVDMHDPAENPFFADENPFPPEMP
(493) DNA topoisomerase 1 [Desulfovibrio alaskensis G20]
1
MGKDLIIVESPAKVKTIKKFLGNKYMVQASVGHIRDLPTKELGVDEENDFSPDYQVIQGKQKVVSALREAAAKADNVFLAPDPDREGEAIAWHVAEIIAKENKNISRIQFNEITARAVREALENPRELNRSLFDAQQARRVLDRLVGYKISPILWNKIKRGISAGRVQSVALRLIVDRERERYAFTSEEYWVFRANLAAETPPPFKAELFKVDDKKPAIASAEQAQELEKSIEGKAFIVDSVQEKERSRKPQPPFITSTLQQLASQRLGFSAKRTMSVAQRLYEGLDLGDMGTTALITYMRTDSVRISDEARDSARELIASLYGKEYCPAKAPVYKTKGSAQDAHEAIRPVDVTLTPDKIKGLVAPEQYSLYRLIWSRFMASQMAPARFHDTTVLIGCGGTQWRVKGERLLFPGYMAAAPASAKEANVELPPMQQGQTLELTLLEKEQKFTQPPARYSEASLVREMEEKGIGRPSTYASIISTIVDRDYTRLEEKHFVPTDLGFVVCDMLTNHFGTLMDIGFTAQMENSLDKVAEGDLDWVALMKDFTSDFNPTLASAAKEMKTVKAGLETDIVCSECGKPMAIKFGKAGPFLACTGYPDCKNTSNFTRDESGTIQLVEREQEELKPVGTCPECGKDLVVKQARTGSRFIACTGYPDCKHTEPFSTGVPCPNDGCDGQLVEKSSRRGKIFYSCNRYPQCDYATWNWPVAEACPQCDSKILTIKSTKARGKHIACPACKYTRALEDEE
(154) DNA topoisomerase 1 [Desulfovibrio magneticus RS-1]
1
MGKDLIIVESPAKVKTIKKFLGNAYAVEASVGHVRDLPSKKLGVDEKDDFAPQYQIIPGKQKVVSKLKEAAASASTIYLAPDPDREGEAIAWHVAQIVQEAGVPVHRIQFNEITAKAVREALSHPRDINEKLFLSQQARRILDRLVGYKVSPILWQKVKSGISAGRVQSVALRLVVDREKERRAFVPVEYWNFKARLAADSPPEFEAELAKYQGKKLEIGSAEAAAAAEAAITGQPFVVTAVTEKERKKSPPPPFITSTLQQAANQRLGYSAKRTMGAAQKLYEGLELGDSGTVALITYMRTDSTRIADEARDAAREYITEALGPDYYPEKARHFRSKAGAQDAHEAIRPIDVRITPADVKTLLPKDLFSLYKLIWERFVASQMAEARFWDTAVDVTAGPGLFKAKGQRLIFPGYLKVYGQEAGDEAKSLPKLDKGQELTLLELKKEQKFTQPPPRYTEASLVRELEEKGIGRPSTYAAIISTLIDRDYARLEEKHFVPSELGETVSDLLAEHFVKIMDVGFTAGMEEALDAVADGRTDWVNLLKDFTEDFNPTLAKAAKDMAKVKAGKETDVKCELCGKPMVIRFGKAGEFLGCSGYPDCKNTKEFDRAPDGAVIPRERKAEEVASVGACPTCGKDLVVKKSRTGSRFIACTGWPDCKYTKPLSTGVPCPKEGCSGTLVEKSSKRGKVFYACDAYPQCDFAVWDWPINEPCPQCDSKILVRKKTRDGELITCPSKSCRYKRAVGGKKDEGEGEE
(553) DNA topoisomerase 1 [Desulfomicrobium baculatum DSM 4028]
1
MGKDLIIVESPAKIKTIKKFLGGGYEVEASVGHVRDLPTKTLGVDEGNDFAPDYQIIPGKAKVVSKLKSAAKAADTVYLAPDPDREGEAIAWHVAEVIRTSNPNVKRIQFNEITAKAVKEALANPTELRKPLFDSQQARRILDRLVGYKISPLLWKKVKRGLSAGRVQSVALRLIVDRERERQAFVSEEYWVFKITVQGETPPPFDADLWKVDGEKPVIGDEKTALALESRVDGQSYVVRDIVEKERQRHPRPPFITSTLQQDASNKLGFNAKRTMSVAQRLYEGVELGERGTTALITYMRTDSVRISDEAKDGAREWITRTLGPEFYPKEPRVYKSKGSAQDAHEAIRPVDPSLTPDSIKNNLPPEQYKLYRLIWERFMASQMASARFWDTVATIESGPAQWRAKGERLVFPGFLQIWPQSSDNQSALLPKLVTGQELRLEKLHKEQKFTQPPARFSEASLVHKLEELGIGRPSTYAAIISTLTERDYVHIEEKHFQPTDLGVIVCDLLVEHFAHLMDAGFTARMEESLDHVAEGETDWVALLRDFTLDFNPTLDKARENMTQVKAGMDTGLSCPQCEDGRLVVKFGKNGTFLGCANYPACSFTSNYIRNNAGEIELVKEEAPEELGPCPKCEDGRLVVKKTKTGGRFVACSNYPACRHTKSVSTGVACPKDGCDGELVEKTSRRGKPFYSCSKYPKCDYAVWDFPVAKPCPLCESKILVRKETKARGAHLACPVKDCGYWEKLD
(1398) DNA topoisomerase [Desulfomicrobium baculatum DSM 4028]
7
MPRTLIIAEKPSVARELAGVLGVKGRGDGFLQGPGHIVTWAVGHLVNIAEPAEQNPAWSGRWSMRQLPMLPSRFTLGILPSTAKQYEIIRNFLLDDDIDSVVNATDAGREGELIFRRIYLLAGSTKPIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAAFARAEADWLVGMNFSRLFTLRAGSLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGEFAHEGETFKATWFAAPDFKDSKIWQVEEGQTVVQACAGKDGAVLEMEKKKGRQKPPLLFDLTNLQKEANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVYAHFPEISQSAAANIKDAKKKFECVNDKKVSDHHAIIPTTLRANPATLGKEEWAIYEMICRRFAAAFMDDATFASSTLWIGVEGHRYRATGKIFQDKGWLEAEPWRASEDNPLPNLRKGAAVTAQSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKERGLGTPATRAQIIETLLARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVASPELTGEWEKRLKEMEQGGYAYGVFMHQVREMVSSGVSRVKGSNARPPACPVVSDRKPSKEVNS
(1558) DNA topoisomerase 1 [Bdellovibrio bacteriovorus HD100]
1
MAKKSDATDGIKLVIVESPTKAKTIRKFLGRDYVVESCMGHIRDLPQSAKDIPEKVKKEKWAQLGVNVDKNFEPLYCVPKDKTKVVKNLKDKLEEASELYLATDEDREGESISWHLLEVLKPKVPTKRMVFHEITKDAIQKALKDTREIDFNLVRAQEARRVLDRLVGYTISPLLWKKVAYGLSAGRVQSVAVRLIVERELERVRFKKSSYWGVLAELSKDGVSFESRLQQYKNQRVATGKDFDGLTGQLTAGKDVLVLDEKTAGKLSMDLKSGNWQVTDVEEKPTFRKPAPPFITSTLQQESNRKLGLSSRETMQVAQKLYEQGFITYMRTDSTFLSNEAITASRDCIESKYGKEYLTPQPRNYAAKKVKGAQEAHEAIRPAGNQFMDPDETGLTGTQFRLYDLIWKRTIASQMVDARQKQVSAKITVGDALFGASGMTIEFPGFLRAYVEGSDDPEADLAEREVRLPALKVKDGVKCAKLDPTSHETKPPARYTEASLVQTMEKEGIGRPSTYASVIGTIIDRGYVRKNGTALVPTFTAMIVSKLLSQYLSQYVDLGFTSEMEQSLDNIADGELDWESYLASVYKGPKGLRAMVDNQGDKIDPNEARTMTLEGMDKYKFHVGRYGAYVTTQRDGEDVSASLPDNESPADITPEIAEKLIDQKINGADSLGNDPETDLPVYVLNGRYGPYVQLGDVTPEDDKPKRASLPPGTQPEQVDLAMALSLLQLPKTLGTHPGTGKDIKAGLGRFGPFVVHDGDYRSIPKGESIFNITFEKAMEMLAQPKKGRGRAAPLKELGAHPDSGDAIQVFNGPYGPYIKCGKVNASLPEGATPDTVTLEQAVALINEKGPAKGKGKAKGKAKAAPKAKAAKADGEKPAAKKPALKKAANAKEKAEALGVKKVVTRKSKK
(1499) DNA topoisomerase 1 [Bacteriovorax marinus SJ]
1
MKRASPFHLNKDVIMASSEAVEETKSSKKTAKKTAKASSKKKTTKKKTTTSKKKTAKKKTAKTTKKKTTKKRDLGDYSLVIVESPSKAKTIKKYLGKGYQVVASNGHIKDLPKSKLGVDIKENFQIDLVPITGKKDKIERIQELAKDATAIYLAPDMDREGEAIAHHLAEEIGKKKKMYRVVFNAVTKSAVNNAIENPTELNKSMYESQQTRRILDRLVGYKISPILWDKVQRGISAGRVQSVALRIIVEREDEINAFEPEQWFSIHGVCEKDAQKFEVKYYGESATKKTDLTEKDLVDKILSDVKGKSLDVIDVKKKERKQNPTPPFTTSKLQQEAANKLGFTAKRTMMTAQKLYEGIQLTEHGMQGLITYMRTDSVRTAPEAMGALREFILDKYGKDYLSVEPIEYKKKGSSKVQDAHEAIRPTNLAFTPDSVRGDLEPDQQKLYELIWNKFISSQMSQAIIDQTTVMMEREGHFFKANGSIIKFPGFRTVYLEAAAEKRSRKGGDDEDDNDAGEVKSGLLPVINTGESFTPIEGPTEQEHWTSPPPRFNEASLVKSLEEFGIGRPSTYAAIISNIQDRGYVEKTENRFLPTELGIVVCRMLVESFPNVMDIKFTAGVEELLDQIEDGTIKYKKVLKEFWKEFEVTLEKAKEEMKNLKKQLIPTGINCLKCEDGEYHIKWGRNGQFFACSNYPDCNSTQDFKKHLDGSYEILPKNWFHDNCPNCQKRLEVKKGKYGRFVRCEDYPQCDTTLPYTLDITCPECNVGKFAEKKSRYGKIFYGCSNYPNCENASWTKPYVQDCPSCGYGIMGFKETKRDGKHLECAKCKFKLEWEQTKYGKEELEKQRQEEEALKGSH
(1533) DNA topoisomerase 1 [Geobacter daltonii FRC-32]
1
MPQHLVIVESPAKAKTIEKFLGPDYKVLASFGHVRALPSKQGSVDIEHDFEPKYAVLPESKKHIDAIKKELKQADVLLLATDPDREGEAISWHLLAALGLDKKPNIDIKRVVFHEITKGAIVNAVENPRGISHELVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFVEQEYWTIGADLSTAGKQNFTANLVEADGKKLGKFDIPGKEAADKLIEILDKATYSVEKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSIAQKLYEGIDIGEGTIGLITYMRTDSVVLSQQALDEAHQVITSLYGKEYALAKPRVFKNKAKNAQEAHEAIRPTYISKTPVELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVEISAGKGYKFRVAGTVIRFPGFMKLYIEGVDDETEEKEGVLPPLNEGDSLQLRDLLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYARLDKKRFFPEDVGMVVSELLVNHFTKYVDYNFTASLEEELDQVSRGEKKWKPLLHEFWQPFHNLLKQKEGEVNKSDLTTEATDEICPECGKPLVVKLGKFGKFFACSGYPECKYIRPLDKDKKESAEPVFSEEKCEKCGSQMLIKEGRFGKYLACSAYPACKNMQPLVKPKGTGIKCVECGEGELTEKKSRYGKMFYSCNRYPQCKFALWDLPVEKPCPKCGFPLLVKKVYKREGEFLKCPKDGCDYKEGGKEK
(1416) DNA topoisomerase 1 [Desulfococcus oleovorans Hxd3]
1
MNKPVIIVESPTKVKTITKYTGNAYSVTATSGHLRDLPPHELGIDIDNGFAPDYVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIAFHVADLLKKKGRRFHRVMFHELTKTGIQKGLTEPTELNRNRYDAQQARRILDRLVGYQISPLLWRKVRNGLSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVKKGTKNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAIRKLGFTAKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPEAAHEALAHIRSVFGNDYAPDRPRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKRFVASQMSEAQIDQKTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDKLPQLDEKEVLKLIELDPKQHFTTPPPRFSEASLVKELEENGIGRPSTYATILSTIRDKGYVDLINKAFRPTELGFIVNDLLVENFPTILDIEFTANMENDLDRIESDQLQAVRLLERFYGPFSQRIEAAKDRMRSVKGVGMDTGLSCPECGKELKIKLGKNGPFLACSGYPDCKFSRNYARTDKGTVEPVEPDLTVAEGKSCEKCGSPMVVKQGRYGDFLACSAYPDCKSTQSLNSGANAAPIGVKCPEPGCNGDIVEKKSKRGKVFYGCSRFPKCTFASWDKPVDMACPDCGAPFVVEKTTKKEGTVLTCASEGCGFRQRT
(72) DNA topoisomerase [Desulfobulbus propionicus DSM 2032]
7
MGKTLIIAEKPSVAADIVKALPGKFTNAKTHYESDEYIVSYAIGHLVSIAYPEEINPELNKWTLDNLPILPEEFPLAVLPDTKAQFNALTKLIRRRDVEVIVNGCDAGREGELIFKYILKQATNRSVEHKRVQRLWLQSMTLDAIRDGLGKLKDDQEMRPLEDTALCRSEADWLIGINATRALTCYNSRFGGFRKTPCGRVQTPTLSLLVKRETERREFVPTTYWELHGCFVCGPVAYQGVWIDPAFAKDEEQAHGRRNRIWEEERAKEIADRCTGKPAMVEESSKKSTKGAPPLYDLTLLQREANSRFGFSAKNTLALAQALYERHKLITYPRTDSRCLPEDYLPTVVKVVGQQQQWQYGRFASEALEKKYLKKDKRIFDNKKISDHFAIIPTAGLPKTLSEPELKIYQMIVQRFLAVFFPAAVYHNTRRLSLVEGETFLTEGKILVEPGWRAIYGASSEEDGDKELQALPPDTLVQCEDIDRQEHQTKPPPRFTEATLLSAMEHSGKLVEDEELAEAMKERGLGTPATRAAIIEKLINEKYIVREQRELVPTGKAFELLSLLEARKIDVLASPELTGEWEYKLNQILKGAMTRTQFMKEIREMTGAIVDKVKQGGGTERHEAPFSPVDGARFYETASAYESEDKKLIIRKVLGGRVMDPAEIVELIRGKTLGPFNDFRSKKGKPFTASVHIANSKVEFLFADSTDELNLDEIRGQEPLGLSPVDQTKVFETPAGFLSESALEGDQKKGLRISKIILGKKLEREHISQLLADGRTELIGGFISKRKKPFDAFLLLDAKGKLSFAFPPRGKKGKDKEADNG
(1500) DNA topoisomerase 1 [Syntrophobacter fumaroxidans MPOB]
1
MSKSLLIVESPTKAKTLGRYLGKDFIVKASVGHVKDLPKNRLGINLEKDFQPEYQVIRGKKKVISELHEAAAKSGAIFLGPDPDREGEAIAWHIAEEIGATDKPVYRVLFYELTRKAIQEALAKPDRLNRELYEAQQARRILDRLVGYMISPILWQKVKRGLSAGRVQSVALRLICAREKEIRDFDSREYWTITALLGTQASADAPAKSASRRFKAELFRCGKKKCTISTGEEARELVDRLRPLDYRVSKVERRKKKRHPAPPFITSTLQQEAARKLHFSARQTMNVAQRLYEGLELGKEGAVGLITYMRTDSTRLSADAVQAVRDYIAGHWDKAYLPAKPAAYKSKAGAQGAHEAIRPTDVNRTPETVAGFLTKEQLKLYTLIWKRFTACQMAPAVLDQTSVDIAAGDYVLRASGSIVEFPGFMTLYVEGRENGDEDSETEGLLPELKEGEVLRLEDLKADQHFTQPPPRYTEASLIKELEDLGIGRPSTYATILSTILDREYAVVRKKSLFPSELGWLIDGLMVENFPSVVDVDFTAKMEKSLDEIEQGQHPYRNLLAEFYEQFSKTLESARTNMVNLKAVGRRTDLQCPQCGLPLHIRWSRNGPFLACSGYPDCRFSSDYRRDEKGNIEPVAEESTGETCEKCGRPMILKKGRFGNFLACSGYPACKNTKAPGTGIPCPREGCSGELVERVSRGGRHFFGCSRYPECKTAFSGRPVPGKCPSCGTGPLIEKGGKGGSVKRVCVNPSCKYVETVPAAADRKAAKD
(61) DNA topoisomerase 1 [Lawsonia intracellularis PHE/MN1-00]
1
MGKNLIIVESPAKVKTIKKFLGSGYVVQSSVGHIRDLPKKNIGVDESKNFSPHYEIIPGKEKIVQGLRETAAKVDTVYLAPDPDREGEAIAWHVAELIKDKNSNIQRIQFNEITSKAVQEALSHPQKLNKNLFDAQQARRILDRLVGYKISPLLWKKVKQGISAGRVQSVALRLIVERDEERYTFIPEEYWLFKANLEGSNPPPFKVELWKVNNKKPIIPDAVTAAALEQQIKDKPFIVDSIEEKERQRSPKPPFITSTLQQAANQRLGYTAKRTMNIAQRLYEGLELGDKGTTALITYMRTDSVRIANEAKLAAATLIEQKFGKEYLAKGGNGRNFKGKAGIQDAHEAIRPIDVTILPEDVKPYLAPDQYQIYRLIWSRFIASQMSVAQFHDTIITINCENSQWRTKGERLLFPGFLAAFPNTKEEEDTNLPVLHKGEILKLHSLIKEQKFTQPPPQFTEASLVRELEELGIGRPSTYASIISTLQDRDYVRLEDKHFIATDLGRVVCMLLQDYFKNLMDVTFTAHMEELLDKVAEGKQDWVELLQNFSETFNPTLEEATKAMSQVKTGLETDINCPDCKKPLVIKFGKSGQFLACSGYPQCKFTSNYLRDDKGQIHLQEKVQPELQKIGICPKCNKDLVLKKARTGSRFIACSGYPECNYTEAFSTNVPCPCEGCKGMLVEKSSKKGKVFYACNTYPTCDYAIWNWPIQKSCPTCSFPILVEKITKAKGKHLACPEKNCRYTCELEESDIET
(309) DNA topoisomerase 1 [Pelobacter propionicus DSM 2379]
1
MPQNLVIVESPAKAKTIEKFLGKDYKVLASFGHVRALPSKQGSVDIEQDFTPKYHILPESKKHIDAIKAALKDAKNLLLATDPDREGEAISWHLLAALGLDKKNPGKSIQRVVFHEITKDAIIHAVENPRDIATDLVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFKEQEYWTIAARLGVKPGAEFRASLVEVGGKKLGKFDIPDENVATALNRALKSGSYRVAKITRTERKRNPSPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGIDIGQEGTVGLITYMRTDSVTLSSQALTEAHEVISAAYGAEYALAKPRIFKTKTKNAQEAHEAVRPTSIARTPAELKKHLTPDLFKLYELIWKRTVASQMAEALLDQTSVDIAAELNEAVADCTVAESGAASPFTGAKRCGLRAAGTVIRFPGFMKLYIEGLDDQDEEKEGLLPPLQEGDDLKLHELFPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYTRLDKKRFFPEDVGMVVNDLLVAHFSRYVDYNFTAGLEEELDQVSRGEKQWKPLLKEFWEPFITLLKQKEGEVKKDDLTTTELDEVCPECGKPLAIKLGKRGKFIACTGFKEGCTYTRNLESDASEPSEPVLSDEKCDKCGQQMLIKDGRYGKYLACSGYPACKNIQPLVKPRGTGVVCPECKEGELTEKKSRFGKLFYSCNRYPQCKFALWDPPVEQPCPKCGFPLLVKKVYKRKGEFLKCPKEGCDYTSE
(426) DNA topoisomerase 1 [Desulfatibacillum alkenivorans AK-01]
1
MSKPLVIVESPTKVRTVKKYLGNDYNVAATVGHVRDLPQKNIGIDIDNNFEPQYEVIPGKQKVISNLKKLAKDASEIYLAPDPDREGEAIAWHTAQLLQGKNRRFHRVLFHELTKNAILNSMQNPLELDKSKFEAQQIRRILDRLVGYQVSPLLWKKVQRGLSAGRVQTVAVRMICEREREIQAFDPEEYWSITAHLQKDEPPVFPAKLLKIGDKKAKVSNEEEANAVLKELEGETYVVDRVIKKTVKRNPLPPFTTSKLQQDSIHKLRFSAKKTMLLAQQLYEGIDLGPGEPVGLITYMRTDSTRVSNEAALEALDYIGKVYGPEYRPDKPRFFQNKKKVQDAHEAIRPTNVLRTPNQVSDVLSKDQLALYTLIWQRFVASQMNPALFDQTSVSVKAGRYLFHATGSTLKFKGYLMVYDAGDGDKDDNKIMLPVLEEKMILQCNKLEPKQHFTQPPPRFSEASLVKELEENGIGRPSTYAAILSTIRDKGYVDLVKRYFRPSELGFIVNDLLVSSFGDIFEVPFTAQMEDNLDKVETSQANSLEILNAFYNSFKQDLENAGDKMVSVKGVGVPTGIKCPQCEKELHIKIGKNGPFLACSGYPECRFTRNYDRDDKGGIVMETPPETEETDEVCDKCGKPMLVKSGPYGTFLGCSGYPDCKNTKTMNGGAQQNQATGIKCPVEGCDGEIHERRSKRGKVFYGCSKYPKCDFATWDKPVDKPCPVCQSPYLVEKSTKKSGVYLKCPTRGCKYREDPQ
(497) DNA topoisomerase 1 [Geobacter bemidjiensis Bem]
1
MSQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPESKKHIDAIKKEMKGISSLLLATDPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITKDAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKLGGKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQLLPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFTQYVDYNFTANLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVNKSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEEICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFGKLFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS
(527) DNA topoisomerase 1 [Hippea maritima DSM 10411]
1
MNLVVVESPAKAKTISKFLGKNYSVVASYGHIRDLPKSSFGVDIEDGFKPKYVIPKDKQPIVRELKKLTKDSDLVYIATDEDREGEAIGWHITQATKLDETKLKRIAFHEITKKAILDAIKSPRSIDMDMVNSQEARRILDRIVGYKLSPLLAKKIRKGLSAGRVQSVALKLIVDREEEIQSFKPEEYWTIHLIFENSIQADLTKAYGEKFDKLFIKKEDDKARVSKLKEEIEKESFNVYSITKTKSLRKPEPPFITSTMQMAASTYLGFSAQRTMRIAQSLYEGVDIGKERIGLITYMRTDSVNIAKEALTKVRRTIKELLGDEYLPSKPVTYKTKSKLAQEAHEAIRPTDPALLPDMVKPYLTEDQFKLYDLIWRRFVASQMKPAEFRNTKITFTSYNFEAKASYKELVFDGFLRIWTFSKLNEDKIPILKKNQSVELTEVKPKQHFTEPPPRYTEASLIKELEKHGIGRPSTYATIIDTIIKRGYVVLKDKRFYPEEIGIITSRMLDKFFSDIINVKFTAQMEDGLDKIANRELTKLELLKRFYDKFKVLLENAYENMERIKPEDEPTDEVCPLCGANLVIRHGRFGKFLACSNYPKCKYTKPLQEEITEIKCDKCGAPMVVKYSRKGSKFLACSNYPKCKNTKPYPTGLKCSECGGDLIEYSSKRGRFYGCSNYPECKFTIKGELKNQKCPKCGYSLFVKKKDKWCCANKKCNYCE
(1171) DNA topoisomerase 1 [Geobacter lovleyi SZ]
1
MAHQLVIVESPAKAKTIEKFLGSEYRVLASFGHVRALPSKQGSVDTANDFEPKYHVLPESKKHIDAIKKELKGADRLLLATDPDREGEAISWHLLAALGLDKKPKIPIQRVVFHEITKDAIIHAVQHPRDIAIDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFVDQEYWTIGAKLEKQGGQTLKAGLVAVDGKKLGKFDIPDQKSADALKNAIAQGKAEVASVTRKEMKRNPAPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGVAIGEGGTVGLITYMRTDSVNLSAQALKDAHDLISVAYGKEYALAKPRFYKNKSKNAQEAHEAIRPTYLDKTPAELKKYLTPDLFKLYELIWKRTVACQMAEALLDQTSVDIAVSGQKTDSFILRATGSVIRFPGFMKLYIEGVDDEDEEKEGTLPALDEGEALKLLEVLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASTLNTLVERKYARLDKKRFFPEDVGMVVNDLLTAHFPKYVDYNFTAGLEEELDQVSRGEKQWKPLLREFWNPFISLLKQKEGEVKKDDLTTETLEEACPECGKPLAIKLGKRGKFIACTGFKEGCKYTRNLENSGTEEAAEPEVSEEKCDKCGQPMLIKSGRYGKYLACSGYPACKNIQPLNKPKGTGVTCPECKEGELTEKKSRYGKMFYSCNRYPDCKFALWDPPVTQPCPKCGFPVLVKKVYKKKGEFLKCPKEGCDYTSA
(279) DNA topoisomerase 1 [Pelobacter carbinolicus DSM 2380]
1
MAQSLVIVESPAKAKTIEKFLGPGYKVLASYGHVRALPSKQGSVDVEHNFSPLYHVLPESQKHIELLKKEAKKSRELILATDPDREGEAIAWHLLEALGIDENAKSPEVKRVTFHEITKGAIQEAISKPGHIARELVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPARLYAVDGNSLGKFDINQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQEASRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVALSQVATGEARELITRMYGEDYALDKPRVFKNKAKNAQEAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLIWQRTVASQMATAQLEATTVDIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQEEGTLPPLEQEQPLDCQEVQPSQHFTQPPPRFTEASLVKTLEEHGIGRPSTYASIINTLTTRKYVRLEKRAFYTEDVGMVVNDLLVNHFNKYVDYDFTAQLEEDLDAISRGEREWQPVLKDFWEPFISRLKEKETQISKQDVTTEKTDRICPECGKPLVIKLGRSGRFLACSGFPDCRYTEPLAGQEREEPVMSDQTCEKCGAPMLIKQGRYGKFLACSAYPECKNIQPLVKPKALGITCPQCGEGELMEKKSRYGKIFYSCNRYPKCKYALWDLPIEEPCPKCKFPLVVEKTTKRQGTFRKCPQEDCDWTVVLIPPEPKAATKKTTTQKTAAKKTPAKKTAAKKTTAAKPAEKKTASKKSAAAKPAAKKTAAKKTTTTKAATQKAAPKKTAAKKATKKEE
(1712) DNA topoisomerase [Desulfotalea psychrophila LSv54]
7
MTTKILIIAEKPSVAGDLAKVLPGKFTKQKTHYESDSHIVSYAVGHLVSLCYPEEIDPIYQKWGLANLPILPESFPLKAVENTKSQLNALKKLIRRKDVTEIINACDAGREGELIFKYILKYVWNTSVAKKTIKRLWLQSMTAESIKKGFNNLRENDTMQSLEDAALCRSESDWLIGLNATRALTGFNSRKGGFFLTPCGRVQTPTLSLIVKREAIRNGFTPTDYNCLQANFSFETGSYSGKWIDPNFKKDPKNSYLRQDRIWDKQKALAILEKCQQKPANATENSKESRQSAPQLFDLTALQREANSRFGFSAKNTLGIAQALYEKHKALTYPRTDSRHLPEDYVDTVKEITQNQTGWEFAAIAKTALKEGYIKAQTRIFNNKKISDHHAIIPTNTLPQNLSEPELKIYTMVVQRFLAIFFPPAVFHNTKRYSLVEGQTFLTEGKILLEAGWKVVYAGADGSTGKDKILAPIPTGSPVTCNKIEKEALTTTPPARYNEATLLSAMENSDKFIENEELADAMKERGLGTPATRATIIEKLIKEKYVVREAKDLVPTGKAFELFSLIEAMKIDTLASPEMTGEWEYKLNQIFKGEMTRDDFMQEIRQLTQQIVDRVRDFNTDEERSLAPFSPVGETVIYSTPTAWVSEDGTIAIRKVLGGRLMSNKEIVALLEGKSLGPFSDWRSKRGKNFTATVSLKNNKIEFIFADSTADLDIDSIKKQEPLGLSPVDQTAVFETPVGYMSESALDGESKKGLKISKVILDKTISKENIQQLLTDGKTELIQGFISKRKRPFDAYLLMDKKGKITFEFPPRKPKNKPQD
(1373) DNA topoisomerase 1 [Syntrophus aciditrophicus SB]
1
MPDSLIIVESPTKVKTLKKYLGADYEVLASKGHIKDLPKKTLGIDPQNEFQPTYSVIDDKKKVIADLKKAAKNVSRIFLAPDPDREGEAIAWHIAEEIKAKNKEIYRVLFNDLTKNTILDAINHPGKLDFNKYEAQQTRRILDRLVGYQISPILWEKVKRGLSAGRVQSVAVRMICDREEEIKRFIPEEYWNISVQLKGVTPPPFEARLIKITGKKAKVKNEAQANEIVSRLSGGVKSGSKPTINLSEDRDLQPQFVVSKLEKKEVKKESLPPFTTSKLQQEASRLLRFSAKKTMATAQKLYEGIELGEEGPVGLITYMRTDSVRIAEDALKEVRSYIRENYDPPFLPAKARFFKSKGKTQDAHEAIRPSSMNYNPQKIKHFLSADQFRLYQLIWNRFVASQMNPALYDQTTVEVSADFYTFRAQGAILKFPGYTIVYTEGKEDKEQNEEMESGKILPDLNEGERLTLLKITPEQKFTQPPPRFSEASLVRELEEQGIGRPSTYAAILSTIQDRNYARLEQGKFHPTELGTIVTELLVKNFPKVMDVSFTASLENQLDLIEEGKQKRIETLQEFYAPFEEDLSKARLEMKNIKREETPTDLICEKCQSPMVIKWGKNGKFIACSNYPACKNTRNIEQGEGVERSAKGGEMTDTVCPKCGKNMLIKHGRFGRFLGCSGYPDCKHTMPISLGVKCPQEGCDGEIIEKRTKKGRSFFGCSNYPNCTFAVWDKPIPEPCPQCNSPFLVEKYSRTEGSYKACPNKDCGYRDDQS
(368) DNA topoisomerase 1 [Desulfohalobium retbaense DSM 5692]
1
MSTDLIIVESPAKVKTIRKFLGSDYLVEASVGHVRDLPSSNLGVDEDNNFQPQYQIISGKQKVVSRLKSAAKKATTVYLAPDPDREGEAIAWHVAELLKKTNTNLKRIQFNEITSRAVKDALEHPRDLDERLFYSQQARRILDRLVGYKISPLLWKKVKRGLSAGRVQSVALRLIAERERERQQFDPQEYWVLKAHVQAAAPPPVVAELWKIGGKKPHVANETQALEIEKKVSEAGFHVESVEEKERKRHPKPPFITSTLQQDASNRLGFAAKRTMRIAQQLYEGLDLGDKGTTALITYMRTDSVRISNEARNAAQKWIVSTLGEAYYPEKPRYFKTKGSAQDAHEAIRPVDPTLTPGSIQSYLSREHFRLYKLIWERFMASQMAPARFWDTQLTLASANTLWRAKGERLIFDGYLRVYSADKSQEEVELPKVQAKDALTLEKIDKEQKFTQPPARFSEASLVRKLEELGIGRPSTYAQIISTLLDRNYVQLAKKQFVPTEMGFVVADLLTAHFPQLLDVGFTAEMEKKLDSVAEGDQDWTQLLREFTESFYPTLEKAEQEMQQVKTGVETGVSCPKCGKPVVIKFGRNGEFLACTAYPDCDFTSNFTRDEAGTIVIVEPEPQERQKVGTCPECGQDLVLKKARTGSRFIACTGYPKCKYTQSYSTGVKCPKQDCPGELVEKSSKRGKVFYACNQYPDCKTAYWNWPIAEECPTCGSPILVRKETKARGEHVACPEKGCGYWRELRDDEKH
(1600) DNA topoisomerase 1 [Desulfovibrio aespoeensis Aspo-2]
1
MPKDLIIVESPAKVKTISKFLGKDYMVDASVGHVRDLPTRDLGVDEENGFTPRYEIIQGKEEVVKRLKAAAKKAGTVYLAPDPDREGEAIAWHVAELLRPVNSNIRRIQFNEITARAVKEALENAQDLNQNLFDSQQARRILDRLVGYKISPILWKNVKRGISAGRVQSVALKLLVEREKERRAFKTDEYWPFKVLLEGGNPPPFWLELHKLSGKAVKPGVNHISTQAEAEALQQTLEAGQFTVDSVQEKQRKRDPLPPYITSTLQQDANRRMGYSAKRTMSVAQRLYEGVELGRHGTTALITYMRTDSVRIAKEAQEAARELIIDRFGADYYPSKPRNFKTKGGAQDAHEAIRPVDVTITPDDVKSSLPSEQHKLYRLIWQRFVASQMAAASFWDTTVLVSAPATEWRAKGERLLFPGFLAAMDKSGTEAETELPKLVEGETLRLNELKKEQKFTQPPPRYSEASLVKTLEELGIGRPSTYAAIISTLLDREYARQEEKRFVPTELGFTVSDQLSEHFHALMDVGFTAQMESLLDDVAAGKQDWAKLLKDFGHDFYPTLEKARTEMARSQQETDIVCENCGKPMSIKFGKTGEFLGCTGFPTCRTIKNFTRDENGAIRIVERETPEETGVECEKCGKPMAIKQSRRGEFLGCTGYPDCKNIVNFQRDENGAISVIESEKLQVVGSCPDCGGELLLKKARTGSRFIACSNYPDCTYAAPFSTGVPCPVEGCAGELVEKSSRRGKIFFSCSAYPKCDYAVWNWPVNEPCPKCGHPILTRKTTKDKGEHLACPQKGCGYTREPDEPADTPDTPDLPDMPDDNA
(852) DNA topoisomerase 1 [Desulfovibrio vulgaris DP4]
1
MGKDLIIVESPAKVKTIKKFLGGKYVVQASVGHVRDLPTNEIGVDEANNFAPQYRVIDGKQKVVDTLREAAAKADTVYLAPDPDREGEAIAWHVAALIEGKADNIKRIQFNEITARAVREALENPRDLNRALFDAQQARRVLDRLVGYKLSPLLWKKVKRGISAGRVQSVALRLIVDRESERRAFTPEEYWLFRAMFAKNVPGATPTSPDPQYAPFKAELAKIDGKKAHVADADAANALEDAMRGKPFVITAVERKKRERQPQPPFITSTLQQAANQRLGYSAKRTMNIAQRLYEGVELGEMGTVALITYMRTDSVRVSDEARDAARAFVTETWGADFCPAKPRQFKTKGSAQDAHEAVRPVDVNVTPDSVKHLLPPDQFQLYRLVWSRFVASQMAPARFDDTTVAIACGPAEWRAKGERMLFPGFLAAMPQKEEGDAELPPLQEGETLHPVSVEKEQKFTQPPARYTEASLVRELEERGIGRPSTYASIISTLIDRDYTRLEDKHFVPTDLGATVCDLLARHFTTLMDVGFTAQMEDSLDKVAEGGLDWVELLSRFSADFNPTLESAAKAMETVKGGLPTNVTCPECGKPVVVKFGKAGPFLACTAYPDCKFTSNFSRDEKGDIVIEQRAREELEAVGTCPECGKDLVVKKARTGSRFIACTGYPDCRHTEPFSTGIACPREGCDGQLVEKSSKRGKIFYSCNRFPKCDYALWDWPVPGPCPVCGSPLLVKKSTRAKGLHIACPEKTCRYTQELPDDEG
(749) DNA topoisomerase [Desulfovibrio vulgaris DP4]
7
MSKTLIIAEKPSVAREIAPLVGAQGRRAGYLEGPDHLVSWAVGHLVGIAEPEEQDEAWAGRWTLEQLPMLPPRFQLRVLPETADQFAVLQRLLLDDRVTGIVNATDAGREGELIFRRIYLVAGCDKPVRRLWASDMTEEGLRKSLARLLPDEEKRNLGLAAFARAEADWLVGMNFSRLFTVKSGGLVSVGRVQTPVLCLLADRRRDIEHFTPQDFWTVEATFDKNLDAGTSTGTRPMTSPAARSTVPCLAESGPATGDAPPAPDGDRTTQSEAQTDEGTKPDAQADALSDASSAAPATSAPDTPVASDVPDAEIAAPEAAANDDRFRGVWHRPPDRRETRVDSGEEADAIATACTGKLGIVESVQGRAGTQQPPLPFDLTTLQREANTRFGYSAKDTLTHAQSLYETRKLITYPRTDSRHLTKELFGEILNHLRAVHHLYPEETMLAVGRIKSGKARFACVDDRKVTDHHAIIPTARKGNLTQLSAPERNIYDMVCRRTIAAFCPEAKFSTSTVTVMVGEHPFIAKGKVFKDKGWMVVEPWRTAEDTPLPQLRKGSKLLTLDVGPVKRQTKAPAHFTDASLLAAMETAGRLVEDDALRQAMKERGLGTPATRAQVIETLVARGYVAKQGKKLVATDRGMQVAETVTTLLPDVASPELTGQWEKRLKDIEAGVDSYPAFMRSIRESVWHGVHRIRNRDIRPLLRDIAARNSRPPDGRCPLCGGDVVETPRGFACKGDSKGKTEGDSTAARCPFIIWKEMHGKAMDEDIVRELLAKGRTAEAFDLTSRQGKSFRAHLVLEGGRVGLDFVRDRTPFRRDEDPQRTVHATGARPAAVPDVDTTSDAHPGADDASAPLTESSHAEGG
(1058) DNA topoisomerase 1 [Geobacter metallireducens GS-15]
1
MPQHLVIVESPAKAKTIEKFLGKDFRVMASYGHVRALPSKQGSVDVANDFEPKYAILPESKRHIDAIKKELKESDILLLATDPDREGEAISWHLLAALGMDKKKNAVPVKRVVFHEITKDAIVHAVENPRDISLELVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIKAFQEQEYWTIGAELGTGKGQKFSANLVEAEGKKLGKFDIPDGTAADRLVKALENGAYTVDKVAKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGVAVGDEGLVGLITYMRTDSVVLSNQALQEAHEVITSLYGKEYALAKPRFYKNKAKNAQEAHEAVRPTSIARTPVEVKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGYRFRAAGTVIRFPGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLQKLVPEQHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLLERKYARLDSKRFVPEDVGMVVNDLLTNHFTQYVDYNFTASLEEELDRVSRGEKQWKPLLHDFWGPFSSLLKQKEGEVSKADLTTEATDELCPDCGKPLVVKLGKRGKFIACSGYQEGCTYTRNIAQGEQQEPAEPVFSEEKCDKCGSPMLIKDGRFGKYLACSAYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPGPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
(1189) DNA topoisomerase 1 [Geobacter uraniireducens Rf4]
1
MPRHLVIVESPAKAKTIEKFLGTDYKVLASFGHVRALPSKQGSVDIEHDFEPKYAVLPESKKHIDAIKKELKNSDSLLLATDPDREGEAISWHLLAALGLDKKKPAIDIKRVVFHEITKGAIIHAVENPRSISHELVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFTEQEYWTIAAQLATGAQQNVTANLVEAEGQKLGKFGIPDKAAAERLTEILANGSYQVDKVTRSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSIAQKLYEGIDVGEGTVGLITYMRTDSVVLSQQALDEAHEVITSLYGKEYALAKPRFFKNKAKNAQEAHEAIRPTYICKTPVELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGYKFRAAGTVIRFPGFMKLYIEGVDDETEEKEGVLPPLNEGDPLKLKELLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYARLDKKRFFPEDVGMVVSELLVNHFTKYVDYNFTASLEEELDRVSRGEKKWKPLLHDFWEPFQTLLKQKEGEVNKSDLTTEATDEICPECSKPLVVKLGKFGKFFACSGYPECKYIRPLDKDKKDVAEPVISEEKCDKCGSQMLIKEGRFGKYLACSAYPACKNIQPLVKPKGTGIKCVECGEGELTEKKSRYGKMFYSCNRYPQCKFALWDLPVEKPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYKEGGKEK
(1138) DNA topoisomerase [Desulfobacterium autotrophicum HRM2]
7
MTELILTEKFSVASDFAKALGVKNKKDGYFEGDAHVITWAVGHLVELFEPDDYDAGLKKWRVETLPLIPERFRYKPITRTLQQFRTIKALLTQRQFDRIIIATDAGREGEVIARTILLESGFRDKERIMRFWTSQALVPKVVRDTMNQLKPITDYDRLWRAGYYRQVSDWLVGMNLTRLMTVRLGDLFSVGRVQTAVLAMLVDRRNEREHFIPETYWNFKVLFSGDKGRWTGRWFKEKETRITDKPQADALLERFQAEKAPGVVVSMKKETKQEPPPLLFSLTDLQQEANNRFGFPAKKTLAIAQALYQDRKCLSYPRTDSKVLGTASLGLVNTVLGKLEQACPDLFAFVDPKRVSLSNRRVFNDAKLTDHHALIPFKPISEAASRDEKLLFDLVVRRFAAAFHPDCRFESTRVVTLFAKETFQTRGKVILDPGWQRVYGTGIRDKAEAEIIPPLVEGDEGAVEKIEREEKQTSPPPDYSDSLLLKDMTNPGRYVAEEEIKRLYRGDIGIGTQSTRAQIIETLISRGYVQRAGKRLLATDKGGYLVTQLRKCPISSVLTSPEETARWEMQLNTIALGEGSDIRFLDHIKAFVTNAVAELKSAGLNVKLFKAEQPQAAVIGICPACGKAVRENPKAFSCEDRGCEFVIFKRIAGKSISAKMATNLLQYRKSGPFKGFISKKKKRFSASLKIVNENGHWKVTFDFNNQGKASSNNGQASPDPRRSISTVERVRSEPRGPESLSAPGSEPTQGAETMRCPLCNGTIIEGNRGFGCSNWRPEHGDCRFVIWKEIAGKTLTLQNLETLIAGKKTRPYVLKNSNGDKFKASMKMVKAPGQGVAIEVEPQGEGQGFKVLCLR
(306) DNA topoisomerase 1 [Desulfobacterium autotrophicum HRM2]
1
MKKPLLIVESPTKVKTLKKYVGKDYNVTATVGHIRDLPPKELGIDIEDDFKPKYITIQGKTKVIQAMKSAAGDTDTVYLAPDPDREGEAIAFHAAEVLKKKGRTFYRVLFHELTQKGISEALENPLDLNHDRYEAQQTRRSLDRLVGYQISPLLWRRVQGGLSAGRVQSVAVRIICDRERIIRAFEPEEYWTITADLATDLPPTFTAALARIDNKKAVIPDQQTAEKIVGELENAAFVVEKIVSRTIKRNPLPPFITSKLQQDAINRLRFTAKKTMLVAQQLYEGIEIGTGGPEGLITYMRTDSIRIADEAAQEALEHIRQTFGPEYALATPRFFKNKNKAQDAHEAIRPTSVLNTPERLKSFLGEDQFKLYELIWNRFVASQMAQAIIDQNTISIQALNYTFTVGGTTVKFPGFMALYAAIDEKADKAKQKLPIIEQGMGLERKAIIPKQHFTKPPPRFSEASLVKELEENGIGRPSTYASILSIIRDKGYVELINRYFVPSELGFIVNDLLMTSFPEILDTDFTARMENDLDEIESGTKHSLGVLKAFYSTFKEKLDHAKENMLSVKGVGIPTGLSCPLCGKPLNIKMGRNGHFIACTGYPECSFSSNYTRDEKGAIQILETKTDNTKVKDCIKCGSPMVKKEGRFGEFLACTGYPECKHTESVNGDAGGRETGAKCPEPLCNGVIVEKRSRRGKTFFGCNKYPECTFASWDPVVNKPCPKCNSSYLIEKQTKKEGKFLKCPNKECTYKESLDD
(1557) DNA topoisomerase 1 [Myxococcus fulvus HW-1]
1
MATRTKKKVEETEAAEEKAPAKKAAAKKKPAARKKTVAKKKTAARRRTKKGDEDALPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREGEAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQISPLLWKKVRRGLSAGRVQSVAVRLIVEREEEIKAFVPEEYWTLDALLEGPSGPPPFKAKLSKVDGKKVELKDRATTEGLVAELQSASFSVAKVDRRERRRNAPAPFITSKLQQEAANRLSFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFLPDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKGFFEAMGEEDMYRLYELIWNRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEGADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVMVEEETTDELCEKCGKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRDGPYVACPNKECDYRREITEQPAGPGGSPEASSAA
(1338) DNA topoisomerase 1 [Geobacter sp. M18]
1
MSQNLVIVESPAKAKTIEKFLGPEYKVLASFGHVRALPSKQGSVDVEHEFEPKYAVLPESKKHIDAIKKEMKGITSLLLATDPDREGEAISWHLLAALGLDGKKKASFDIKRVVFHEITKDAIVHAVQHPRGISVDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIGAKLETAKKQALTAALVEAEGKKLSKFDIPNQEAAFRLFGLLGGKEFPKQEGEEGSAPLVVKAPVNPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEDARQLITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYISKTPIEVKKFLTSDQFKLYDLIWKRTVACQMAEALLDQTSVEITAGEGFRFRVAGTVIRFAGFMKLYIEGVDDEAEDKEKEGMLPPLKEGDILKLQQLLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFNQYVDYNFTANLEEQLDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVSKSDLTTEATDEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEELCDKCGSHMLVKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCTACGKGELIEKKSRFGKLFYSCNRYPECKFALWDQPVQKPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYQSNKE
(95) DNA topoisomerase 1 [Desulfobacca acetoxidans DSM 11109]
1
MTKSLLIVESPAKARTLQKYLGKDFEVRASVGHIKDLPKKELGVDVEKNFIPKYVTIDGKTKTIQDLKRAAHDVEDIYLGPDPDREGEAIAWHIAEVLKSGKHRFHRVLFYELTPRAIQEALAKPMELNRPRYEAQQARRILDRLVGYQISPLLWEKVKRGLSAGRVQSVALRLICDREREILAFVSQEYWSLTAHLKAEQPPPFQAKLIRYKGKKLELAKAEQTQAVVAALEGAQYTVTAVEQKERQKKPLPPFITSTMQQEASRKLRFAAKKTMQVAQRLYEGKDLGAAGPVGLITYMRTDSTRVAGEAVAAVRDFIRQEFGPDYLPAKPNAYKSRKTAQEAHEAIRPTDVSRTPAAVAPFLEKDELRLYELIWKRFVASQMEPARLLVTTADISANHYTFRATGTVVKFPGFTVLYEETPDAAGEEEDIKLPPLKVGELLELLQLEPKQHFTQPPPRYTEATLIKELEKQGIGRPSTYATILSVILGRLYVAKIKAGFKPTELGLMINDLLVASFPKIMNVGFTANLEDRLDAVAEGEVIWQEVLRDFYGSFSQELQEAKQVMPRVKSLATGLTCPQCGAELLIKWGKTGEFLGCSGYPECRYTRNFSRDEQGRIVPEEKNNVPAPDLPEITEVCPKCGQTLVAKQGRFGPFLACPGYPKCRYTRSLQEEEGEVEAVPCPQPDCTGVLRARKSKRGVFYGCSNYPECTYALNYPPVAKACPQCGFPVMVRKELKKQGKILACPQKSCGYTEPDLDEPGTD
Family distribution
Taxonomy tree
Deltaproteobacteria