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Taxon : Clostridiaceae
Informations
Name
Clostridiaceae
Rank
family
# topoisomerases
51
Lineage and sub-taxa
Lineage
Bacteria
>
Firmicutes
>
Clostridia
>
Clostridiales
>
Clostridiaceae
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(1123) DNA topoisomerase [Clostridium phytofermentans ISDg]
7
MKVGKFMGKSLYISEKPSVAQEFAKALKSNFRKSDGYMESEDSIVTWCVGHLVTMSYPESYDPALKKWSLQTIPFLPKEFKYEVIPSVSKQFQVVKGLLNRSDVDKIYVCTDSGREGEYIYRLVDQMAKVPKNKEKRRVWIDSQTEEEILRGIREAKPLSDYDNLSSSAYLRAQEDYLMGINFSRVLSLKYGYTVNNFLKNEKHSAIAVGRVMTCVLGMVVRREREIREFVKTPFYRVMLTLETSDRTFDGEFKAVEGSKYYLSPLLYKENGFREKQEAEKLITMLTGYESEYETRIENNNKNSYLAKLKQDEESKQLVAEIVSMEKKKENKNPPLLFNLAELQNECSKLFKISPDETLKYTQELYEKKLVTYPRTDARVLSTAVSKEIYKNIKGLTALSQFQPFAEEVLALGSYKNIAKTRYVNDKQITDHYAIIPTGQGFGALSSLSPTAKRVYVSIVKRFLSIFYPPAVYQKIAITTKIDTESFFSSFRVLIEEGYLKVAGYQGNTNTAMQDTDGSAKTSTKTEADGKEKGSDEETEEEKDYDATFFEVIKSLKKGMKLPVRNFTIKEGETAPPKRYNSGSLILAMENAGQLIDDEELRAQIKGSGIGTSATRAEILNKLVKINYLSLNKKTQIMTPALMGELIYDVVNVSIRSLLNAELTASWEKGLTMVSDGTITKDEYIAKLEGFVGRMTEGVKGVNNANLLIPYFEQVAQNYKK
(376) DNA topoisomerase 1 [Clostridium phytofermentans ISDg]
1
MPKYLVIVESPAKAKTIKKFLGNNYEVLASNGHVRDLPKSQMGIDVENGFEPKYITIRGKGDLLAKLRKEVKKADKVYLATDPDREGEAISWHLSQTLKLDDKSASRITFNEITKNAIKNSIKEARDIDMNLVDSQQARRMLDRMVGYKISPLLWAKVKRGLSAGRVQSVALRIICDREEEINDFVPKEYWNLDASFKVKGEKKSLVAKFYGDTKKKISIESKEEMDKILADLKGAQFKITEVKRGERQKKSPLPFTTSTLQQEAAKLLNFSTQKTMRIAQQLYEGVDVKGHGTIGLISYLRTDSIRVSEEADTAAREFIKTQYKPEYVNSQDVNKTTGKKIQDAHEAIRPTYVDLTPVIVKESLSREQFRLYQLIWKRFIASRMQPAKYETSTAKIDGNGYRFTVASSKLIFDGFMAVYASEDEEEENTTSNMMSLSEETQLTFEEFNSSQHFTQAPPHYTEAALVKTLEELGIGRPSTYAPTITTIIARRYVIKENKNLYVTELGEAVNRIMKQAFPTIVDVNFTVNLEALLDGVEDGVVNWKTVVSNFYPDLESAVQDAEKQLEQITIEDEKTDVICSECGRNMVIKYGPHGKFLACPGFPDCRNTKPYFEKIGVACPLCGSDIIIKKTKKGRRFYGCENNPECEFMSWQKPSGKLCPICNGIMVEKGQKLVCVNEGCGHVENKEQN
(180) DNA topoisomerase 1 [Clostridium sp. BNL1100]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAVKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATKMICDREDEIENFESQEYWSITAKLTKPKASPNFEARFYGIGKEKIELTNEEQVNSILDEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGFTTKRTMMVAQQLYEGIEIKGHGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPENPRVYKNKSASQDAHEAIRPTYMDMAPEGLKEFLSAEQYKLYKLIWDRFISSQMSSAIYDTVAADITAGKYMFKANGSKVKFPGFMVLYIEGNDVEGKDEDGEQNEKENNLPQLNEGDILELKKNTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAQMESELDDVEDGNKEWKAVMRDFYSSFAGVLKEAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNTKPIVEEAGVECPLCKGKVLIKKTKKGKKYIGCERNPECSFMSWDMPSPNKEMCPVCGAFMLQKSSGKKKALKCSNDKCTSNTETSTDTK
(250) DNA topoisomerase 3 [Clostridium sp. BNL1100]
2
MGFTLVIAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFSVQWQDGRTNQTRTFNKEEADGIVAKITGQIGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKISVTKRFVDNSKVTDHHAIIPTEQFVDLSSLNSEERNIYDLIVKRFIAVLSQPFEYEQTTVKLNVAGESFYAKGKIVRSSGWKTVYDGFGKLDEDSDEDDNDQSLPDIQKGHKAKVVAPKAINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERRGKEIYPTSKGTQLISLVPADLKSPELTAKWEQQLSLISKGKANSNAFVGEMKNYAKKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHVCPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGEQVDKKDVARFMRQQDKDESINSALADALAKWKK
(1328) DNA topoisomerase 1 [Clostridium ljungdahlii DSM 13528]
1
MGQKLVIVESPAKAKTIGKYLGKNYVVKASMGHVRDLPKSQLGVDIDNEYTPKYITIRGKGELLDKLRKEAKKSEKVYLATDPDREGEAISWHLSHALKLDENEKCRIEFHEITKNAVKSSIKSARLININLVNAQQARRVLDRLVGYKISPILWRKIKWGLSAGRVQSVALKMICEREKKIVDFVPQEYWTIECELHKENESKCFNVKLTTFNKKKIEIGSKDEVDKIIEELKQGQFIVKSIKNTNKNRTPLPPFTTSTLQQDAYKKLNFSTKRTMSIAQQIYEGVDIKGYGTIGLITYMRTDSVRIAQEAQEACRDFVANKFGKEYIEEKPRNFKSKKNIQDAHEAIRPTNVEITPEIAKENLKPEQYKLYNLIWNRFVASQMSSCQIDVKSIDIVNSNYGLKVSGSRIKFDGFMKVYKYATEEEKSDISLPKLEEGEKLLRKSIDGKQHFTQPPARFSEASLVKTLEENGIGRPSTYAPILSTLLDRKYIQREKKTLIPTELGDIVNNIVSQYFKQVVDVEFTAAMESKLDSVEDGKDDWRKVVGEFYEPLKKSIEIAEKEVARITIEDKVTDIKCDKCGRNMVIKHGRFGDFLACPGYPECKNTKPIVEELDVKCPKCQGKVLIKRSRKGRKFYGCSNYPDCDFVSWFEPTNEKCKECGNYMVKKYNKSKGNYLECSNSECKHREYKAVEDGDEKTAK
(151) DNA topoisomerase [Clostridium ljungdahlii DSM 13528]
3
MKSLIIAEKPSLAMSIVKSIGSMERNNGYFENKNYIVTFAYGHLLQLYDVDDYFGREKTKWTLKELPFVPKEFKFRLRKDEGVKKQYEIIKSLIKRNDVQEIVNCGDADREGEVIVNNIIFRAFEEEHVTKPVKRLWLPEQTRQTIIQSLKDLRDDIEYKNLYDEGLARTYLDWSYGINLTRYLSIKSGSFLPVGRVLIPIVKYVYDRDEKIENFKPETYFEIGAVINKDNLHIKTKLKDRKFAANERDKAEKLLNNLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKEEKMSLDDTLKNLQKLYEAGYTTYPRTNTEYLAENEKDRIKSVIAAVKENFNADISFKDNKKIFNSKKVESHSAITPTIKIPRKEKLSEGEKKVYTAIKNRFISNFLNEETIIEETSVVIKIDDEIIQLKGNVIKSPGFLKYEKSKRENELPQFVEGEELDTKLSVDQKETQKPGRVTESELNNFLKNPFKKQEVEDLEGENDDEEYKLILEGCEIGTVATRAGIIKNAKKYEYIKELKGHLECENKGKKLIEALEKLKIDLNKEKTVEFGKQLKKVYKEEIGINEIIDKVKDELNSIVQNGNKIKIEKLYLYNNKSDSKIKIESIGKCPVCHEGEVVENKSGYGCNRWKEGCKFFVGNKIAGKEILKTHVKKLIKDSKTNVIKGFKGKSGKKFNASLVIDKEGKIVFNFENEVLGKCPCCGHDIVEGKNAFGCSNWKEGCKFTIWKNDKYLACMGKKPTKTMVCELLKNGKVKIKGLKGKDGNIFDAYLMLIKNENENKDKYPYKWKMQITK
(22) DNA topoisomerase 3 [Clostridium ljungdahlii DSM 13528]
2
MGKILVLAEKPSVGREIARVLKCRKKGNGWLEGEKYIVTWALGHLVTLADPEAYDDKYKTWKLEDLPMLPKYLKLVVIKQTGKQFNAVKEQLNRKDVTEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAINEGFRNLKPSSQYDNLYRAAQCRAEADWIVGLNVTRALTCKHNAQLSAGRVQTPTLAMIVHREEEIKNFKPKDYYSIIGNANGYTLQWQNGNGHFNTFDENFANKVVSKVNGQNGKILDVIKSDKKKYAPALYDLTELQRDANRLFGYSAKQTLSIMQRLYENYKFLTYPRTDSRYISADIVPTLPERLKAISVGNYSKFAMEIMRGKIRAHKGFVDDSKVSDHHAIIPTEEKVILSKLSNEERKVYDLVVKRFLSVMLPPFEYVQTTVKAEINGENFAASGKVIKSKGWKAVYDKNEDFDDNDGLHENQLKEQVLPNLNRGDSIKLTAVKMHKGQTKPPARFNEGTLLSAMENPQKYINMNKEYAKTLGETGGLGTVATRADIIEKLFNTFYIEKKGKEIIPTSKGKQVVELVPEDLKSPLLTAKWETDLNLISKGKLNDKSFIGNMRNYSVKLVEDVKGSHDKFRHDNLSGAKCPECGKYMLEVNGKHGRMLVCQDRACGHRENLAKLTNARCPECHKKLELRGHGDGQVYVCINNNCNFREKASSFNKRFDNKQGKNSKRDVANYMKKMKKESEVPMNSALADALAKLKLK
(1037) DNA topoisomerase 1 [Clostridium tetani E88]
1
MIMGQKLIIVESPAKAKTIGKYLDKTYHVEASMGHIRDLPKSQLGVDIDNNYEPKYITIRGKGELLTKIKKHAKKCDEIYLATDPDREGEAISWHLSQALKLEDNKKCRIVFNEITKSAVKNAIKEPREIDIDLVNAQQARRVLDRLVGYKISPILWRKVRWGLSAGRVQSVVLKMICDREKEIEEFIPKEYWTIECKLNKDRKDFLVKLISKDNKKIEINTEEESNNIIKELKQGQFTVDKIKKTNKNKNPLPPFITSTLQQDAYRKLNFSTKKTMSVAQQLYEGIDIKGHGTVGLITYMRTDSVRISKEAQNKARQFLENVYGKEYIPEKPRDYKGKKNIQDAHEAIRPTNIEITPKIALENLNSDQYKLYSLIWNRFMASQMAACVMEVNSVDVKNSEYIFRATGSIVKFDGFMIIYEYLNEDEKENINIPKLEKGELLKEKSIDSKQHFTQPPGRFSEASLVKVLEDNGIGRPSTYAPIISTLLERTYIERENRTLKSTELGVIVNNIMVEYFKPVVDAEFTAEMENKLDSIEEGNENWKNTVDEFYSPLKELIETAEKEVEKVTLEEKVTDVKCEKCGNNMVVKHGRFGDFLACPGYPECKNTKPIVHQLDVKCPKCHGEIVLKKSKKGRKFYGCSNYPKCDFVSWFEPVERKCDVCGNYMVKRYTKAKGDYIECSNKECKHKIMPEKKQE
(405) DNA topoisomerase 3 [Clostridium tetani E88]
2
MGKTLVLAEKPSVGREIARVLKCNKNSRSYIESNKYVVTWALGHLVTLADPEVYDNKYKKWEMETLPMLPKYMKLCVIGKTSKQFNEVKKLMNRNDIDEIVIATDAGREGELVARWIIEKARVNKPIKRLWISSQTDKAIIDGFNNLKPGKDYENLYKSAVCRSEADWLVGLNVTRALTCKYNAQLSAGRVQTPTLALIVEREEEIKNFKPRDYYNIVAKTKGIQFNWQDKKGQMATFNEDFANNILAKVSGEIGNVTEVIEKDKKQYAPALYDLTELQRDANRIFGYSAKETLSIMQRLYENHKVLTYPRTDSRYISKDIVATIPQRLKSISIGIYSKFAEEILRGKIVAHKGFVDDSKVSDHHAIIPTEERVKLSNLSGDERKIYDLVIKRFLSVMLPPFEYIQTTIKVEVNGEVFIAKGKNIKHNGWKAVYNKEDLNEDNNDGDGLKEQVLPQIIKGDAIKFNLVNINKGQTKPPARFNEGTLLSAMENPQKYIKLNKEYAKTLGETGGLGTVATRADIIEKLYNSFYIEKKGKEIIPTSKGKQIIDLVPQDLKSPILTAEWEKKLELISKGKISGKEFINNMRNYSTKLVQDVKNSNEKYIHNNLTGTKCPNCEKYMLEVNGKRGKILVCQDRECGYRENISRFTNVRCPECHKKLELRGEGEGQIYVCSKCTFREKLSSFNKRFKEKGNNADKREVSRYMKKMKEQDKEPMNSALADALAKLNLK
(1761) DNA topoisomerase [Clostridium tetani E88]
3
MNLAKVIIAEKPSVAKNIADALNIKTRKDGYFEGKEYLITWAFGHLLQLYDAKDYNEIMKGWRLEKFPFIPMNFKYKIKQQNNNKNITDEGAEKQINIIKSLIERENVEAIISATDLDREGQIIGDELFSYLQIKKPIYRLLLNEWTPDEVKNGMKNLKCNEDMKFLRDAGISRQWSDWIIGINLTSVATLKYNIEDNKILNIGRVILPTLKIIYDRDKEIENFKATTYYKLLANFKTKKDKEFEGTYYEKNSEKFQDKSYLKIIEDLLKNKTYNIVDKHVEKKKEYAPYLFNLSNLQGYVTSKYKGWTSDKVLKVAQSLYEKKFITYPRTSSSVLDESLEGRAKKVLETLKKGLSYENQIRFNKSKRIFDSSKVESHSAITPTYIKPSKLTRDEEIVYIAIKNRFIMQFMPIAEFEETKITIKANDEDVKGEFLSKGKVQIVEGWRIVEKIETKDTILPLVEVKEKVDAVNSKIKTVTKKPPKHHTEKTLLRVMETCGKSFKDDENSEEMMNAILSGFSIGTAATRADTIKKLKDIGYIEAKGKSLICAPLGRTMIEIFPVKELLDLEYTGKLEKTLSDIEKGKFGKKEFMDLIYEFTNRAVELIKSDNSMLNKIKINLPEGVENLGKCPQCGNPVIEGSKGYGCSNWKNGCKFTIWKNDKYIQSFGKKVTKDMVKILLEKGRVGFRNLKSKKGNVFTAYFTYENNKEKGYYSWKMHFIN
(557) DNA topoisomerase III-like protein [Clostridium perfringens str. 13]
3
MKKVIIAEKPSVARNIADAFNIKKRKDGYFEGEEYLITWAFGHLLQLFDAKDYDENMKGWRMEKFPFIPEVFKYKIKQDSLNRNIIDKGAEKQIKIIKGLIDREDVDGIISATDFDREGQVIADEIFLYFSEKKPVYRLLLNEWTPDEVKKGMEKLKPNEEMQSLQDAGIGRQWADWIIGINLTSVTTIKYKLNDGQILNIGRVLLPTLKIIYDRDKEIENFKSSAYYKLNGTFKTSKNEEFEGTYYENNSEKFEDKKVLDEIKEKIKDKNAEIIEKQTERKKEYPPFLFNLSNLQGYITSKYKGWTSDKVLKVAQSLYEKKFITYPRTGSMALEESLVDRTRNVLEKLKVGLPYEEQIKFVQNKRVFDNSKVESHSAIVPTYMKPNNLTQDERIVYTAVKNRFLMQFMPVAEFEETKITSKINDKEVKGVFISKGKVQLIEGWRVVEKIDSKDTILPMVNEKEIVDLVDSKINKVTKKPPKKHTEKTLLRVMETCGKSFKEDAEEDSEEMMASILSGFSIGTPATRAETIKKLKDVGYITTKGKSLTCTELGRTIVEIFPVKELLDLEYTGRLEKTLSDIERGKVKKEDFLNLIKNFTIEGVKAIKNDDSMAKHFKVEAPEGVEVLGKCPNCGNPVIEGERGFGCVNWKNGCKYTIWKNDKYIASFGKQVTPQMVKLLLANGKVGFRNLKSKKGNTFAAYFIYEKDEEKGYFTWKMEFI
(1152) DNA topoisomerase [Clostridium perfringens str. 13]
3
MKKLVIAEKPSLAMNIVKALNSSESFERKDGYFESENYIISFAFGHLFKLYNIEEYTGEDKGAKWRNDILPFIPKEFKFSIKDDVGVKKQYKILEELIKSNRVDEIVACGDADREGEVIIRLIINNVFNNNSINKKVTRLWLPEQTTQSILYGLNNLKDIDTYNNLANEGFTRTFLDWLVGVNLTRYVTVKSKHLFPVGRVLVPIVQAIYERDKSIENFVPETYYQIESNEKTNDEIIKLVVKELAFTKSEFIKAKSFADELNTYEAIVISKDTKKVKKQPSKLFSLSKLQSLLSKKYKMTFKESLELIQKLYEKGFVTYPRTNTEYLAEAEKGKVKEIIDILCSEGYNLEFKDKKTIFDDSKIESHSAITPTVKIPKEDELKGKMLDVYNTIKNRFISNFLIEETLIDRTIIRIEVGDLEFSLKGDVIVQKGFLEYEPIKKDENTLPNLNVGDKINTNFKAIEKVTQAPGKMTTEMLSNYLKNPFKNYEIENEEEDYKAILDGLEIGTEATRTGIIENAKKYKYISENKSVLSIEPLGRKLIETLDKLNVNLSKEKTVEFSRILKKVYKNELNIDRAVDLISNELKSILEDSKNIEIEAIKEEKEVIGKCPRCGKNIYETSKSFSCEGYKDEPKCQFNIWKEDKFFKDKGKKVTKSIAKNLLAGKKVKMTGLKKKDGNGTYDAFVSLNDTGKYVNYKLDFSK
(735) DNA topoisomerase [Clostridium saccharolyticum WM1]
7
MKLVLAEKPSVAMSLSKVIGANQRGDGYMEGNGYIVSWCVGHLVELSQPEAYDEKYAKWRYDDLPILPEHWQYQVSTSTKKQFGILKKLMLRKDVKSLICATDAGREGELIFRLVYHQCGCKKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCRERADWIVGINATRLFSCLYGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKFRDFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTSLQREANRQLGFTAQQTLDYTQALYEKKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSFQIQPDVPAPVNAAQVINSKKVTDHHAIIPTKTAAGHDISSLPSGEQAILIMLAVRLICAVGTPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGRSSEDAEKNAEACNLPELSEGMTLELAGVDLKEGKTSPPKRFTEDLLLSAMESASSDEFPAGVERKGIGTPATRAAIIEKLVQKGFIERRGDKKTKYLCSTDKGNALVTVVPEQIQSPSMTADWEEKLLKIEHGEYDSDAFMGEISSMVNGLVKTYEAVKGADVLMQPERKVIGSCPACGSDVCETVKGWFCRDKSCKFALWKENRFFQTLGKQMTEELAKQLVNQGKARLTHCYSRKSNRYYDTTVRVETGEDGAAAFKLEFGGKK
(89) DNA topoisomerase 1 [Clostridium saccharolyticum WM1]
1
MANCLVIVESPAKVKTIKKFLGANYEVDASNGHVRDLPKSQMGIDVENDFDPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLMKALKLDELKDKQVYRISFNEITKNAVKASLKTPRVIDMDLVDAQQARRVLDRMVGYMISPLLWAKVKRGLSAGRVQSVALRLICDREEEIGAFIPEEYWNLEAVLKQEGSKKPLIAKFYGDKDGKIPIRNKEELEKILAGLEKQTYQVEEIKNGERIKKAPIPFTTSTLQQEASKVLNFSTQKTMRLAQQLYEGVEVAGRGTVGLITYLRTDSTRIAEEADAAAREYIGKQYGGQYVANGEQQKKSNAKIQDAHEAIRPTDISLTPVMVKESLQRDLFRLYQLIWKRFTASRMQPAVYETTSVRVGAGKYLFTLSASRLSFDGFMSVYVQEDDKEEANVLLGNLEKGSFLKLDKLESGQHFTQPPAHFTEASLVKAMEEQGIGRPSTYAPTITTIIARRYVAKENKNLYVTELGEVVNRMMKKSFPSIVDITFTANLEYLLDKVGDGSVQWKTVVKNFYPDLKEAVDKALVELETVTIADEVTDEICEVCGRNMVIKYGPHGKFLACPGFPECKNTKPYLEKIGVPCPKCGKEVVIKKTKKGRIYYGCEANPECDFMSWQKPSTKTCPKCGAYMVEKGSKLLCSNEQCGYSTDK
(410) DNA topoisomerase 3 [Clostridium saccharolyticum WM1]
2
MKSLIIAEKPSVARDIARVLHCTKNHDGVIEGEAYVVTWGLGHLVTLADPEDYDPKYKEWKMEDLPMMPDQFRLEVIKQTGKQYRVVKAQIHRSDVGEIIIATDAGREGELVARLILEKAGNKKPIKRLWISSVTDKAIKEGFAKIKNGHEYDNLYDAAMCRAEADWLVGINATRALTCKYNASLSCGRVQTPTLAIIARREEEIKNFVPKPYYGISAKCADPALSFTWRDEKSKSFRSFDRDRVEALFNHRKAIGEGVITEVKSVPKKTEPPQLYDLTELQREANRRFNYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDIVPSIKERLEACGVGPYRKLAGRLANQKIKTAPSFVNDKKVTDHHAIIPTEQFVQLDHMTIEERKIYDLVVRRFLAVLYPPFEYEQTEITLDLGGETLAARGKTVKAQGWKEVYENQDEEEEEQELKEQNLPVMKKGDMINGLTVTMTEGKTKPPAPFQESTLLSAMENPVSYMETKDKDMAKTLGETGGLGTVATRADIIEKLFSGFLLEKRGKDIFLTSKARQLLTLVPEDLKKPELTAEWEMKLSEIAGGKLKRAAFMKDIRQYSGELIRQIKTGEGSFHHDNLTSHKCPVCGKRMLAVKGKNNEMLVCQDRECGHREVVSRTSNARCPVCHKKLELKGKGDSQIFVCKCGYKEKLSSFKERRAKEGAGVSKRDVAKYMSEQKKEGNQPMNSAFADAFAKLNLGDNGK
(1620) DNA topoisomerase [Clostridium saccharolyticum WM1]
7
MSKSLYIAEKPSVAQEFANALKANGRRRDGYMESDQVIITWCVGHLVTMSYPESYDPKYKRWSLSTLPFLPREFKYEVIPGVEKQFKIVSSLLNRPDVDTIYVCTDSGREGEYIYRLVAQMAGVKDKKQKRVWIDSQTEDEILRGIREAKDESDYDNLSASAYLRAKEDYLMGINFSRLLTLRYGQHISNYLKSGKNTVISVGRVMTCVMGMVVRREREIREFVKTPFYRVIGTFSKEDPSNPGLSGLDFDGEWRSAPGSRYYESPFLYKENGFKERQYAEELINALSLMDPMEGTVVSIEKKKETKNPPLLYNLAELQNDCSRMFKISPDETLKLVQELYEKKLVTYPRTDARVLSTAVAKEIYKNIGGLKSFTPLSEAAAEVMEKGSYRTIEKTRYVNDKQITDHYAIIPTGQGLASIKGLSSLGIRVYEVIARRFLSIFYPPAVYQKYALELAAESVYPGSEPTLQHQMTNKEHFYANFRVMLDAGYLKVAEVSWGKKKQEEGNGGTPSEETVQEENNPESSQNQMNNPLFVAMLGSLKKGMKLSLKKLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLFHIKYLSLNSKTQVIVPTLLGEMIFDVVNASIRQLLNPELTASWEKGLNYVAEGTITPGEYMEKLENFVAGRTAGVLRLNNHYDLHGVFDAAAANYKKPK
(1276) DNA topoisomerase 1 [Clostridium botulinum A str. ATCC 19397]
1
MGQKMGQNLVIVESPAKAKTIKKYLGKNYVVEASMGHVRDLPKSQLGVDIENNYDPKYITIRGKGELLDKLRKEAKKSSKVYLATDPDREGEAISWHLAHVLKIDESEECRIEFNEITKTSIKKAIKSPRRINENVVDAQQARRVLDRLVGYKISPILWSKIKWGLSAGRVQSVALRMICDREREIEEFIPKEYWTIECEVYKEKNKKPFIIKLTTKSGKKIEINNEEEAIEAIQDLKKGEFIVKKIKKTKKNKNPLAPFTTSTLQQDSYKKLNFSTKKTMSIAQQLYEGIDIKGFGAVGLITYMRTDSIRISEEAQKSTLEHIKSNFGEEYIPKTPRVFKGKKNIQDAHEAIRPTNIEITPTLAKESLTPQQYKLYELIWKRFVASQMASCILDSTSISIENGKYGLRASGSLIAFDGFMKVYEYSTEEEKDSIKIPELEDNEILGEKSINKSQHFTQPPARYSEASLVKTLEENGIGRPSTYAPIISTILDRKYVEREKKTLKPTELGDIVNNILSEYFKQIVDLEFTADMENKLDYIEEGKKSWREVVNDFFQPLIESIEIAEKEIAKITIEDKVTDVVCEKCGRNMVIKHGRYGDFLACPGYPDCKNTKPIVEEIDVKCPKCRDGKVLIKKSRKGRKFYGCSNYPDCDFVSWSEPVKEKCEECGSYMVKKQSKAKGEYYECANSECKHRKYLNNKE
(236) DNA topoisomerase [Clostridium botulinum A str. ATCC 19397]
3
MSKLLLAEKPSVARNIGEALGCKTRKNGYLEGNGYIVTWAFGHLLTLYDCKDYDHKLALWSFQNFPYIPTEFKYKVKNDGKNRNVVDAGAKKQLEIIKELINRGDVEEIISATDYDREGELIALLIFNYLKANKPIYRILINEWTPTEIKKGLKDLKKNEEMISLQDAGVSRQLADWVIGINFTSIATMKYTRGKGNLLNIGRVLMPTLKIIYDREIEIKNFKVEEFYELEATFKNKKGEYKGKFFYEKKEKFPNKKIMEKLKAEIKDKSGLVTEKTIEIKKENPPSLFNLSNLQGYITSKYKGFTADKVLKVAQSLYEKKHITYPRTESTALEESIKDKAKKVLEVLKNDLPFKDEIIFNTSKKVFNNAKVESHSAIMPTYIIPKNLTPDERLVYDAIKNRFISQFMKEAQYENTEIVTTVPGENYERLFKTKGKILKCKGWLKLYKEKKKDELLPPIEKDDEVEIKSLKIISKKTKPPAHHTEKTLLKAMETCGKNTKQSEDNEEESNILYGYSIGTAATRAETINKLKYAGYITPKGKSLLITDKGTKLIETFPIRELLDTDYTGKLEKKLYDMEKGKFKKEDFLKEIFNFTVNGVNKIKNIRSNVICDTRVKKDK
(195) DNA topoisomerase 3 [Clostridium botulinum A str. ATCC 19397]
2
MGKVLVLAEKPSVGRDLAKVLKCNKKGNGYLEGNKYIVTWALGHLITLSDPESYDEKYKKWSMDTLPMLPKRMKTTVIKKTSKHFSEVRKVMIRKDVEELVIATDAGREGELVARWIIDKVGFKKPIKRLWISSQTDKAILDGFRNLKPGKNYENLYHSAVCRSEADWIVGLNVTRALTCRYNAQLSAGRVQTPTLAMIVQREEEIKNFKPRDYYSIEGKTKGFTMHWESAKGRFNTFDEDLAKKVVSKVTGKEGKIIEVTESDKKKYAPALYDLTELQRDANRIFGYSAKQTLSIMQRLYENHKILTYPRTDSRYISKDVVGTLKDRLKAISISNYSKFTNEILKGNIKAHKGFVDDSKVSDHHAIIPTEEKPKLGNLSGEERNIYDLVIKRFLSVMLPPFEYIQTTIKSEVIGEKFVARGKVIKSKGWKAVYDREEFDDKNNNSDSDDIKDQTLPKVNKGDGIKFSNFKINKGQTKPPARFNEGTLLSAMENPQRYINLDKESSKTLGETGGLGTVATRADIIEKLYNTFYIEKRGKEIVPTSKGKQVIDLVPKDLKSPLLTAKWERELDSISKGNLRGQIFINKMRDYSTKLVEDVKNSKDKYVHDNLTGKKCPQCGKYMLEVKGKNGVINVCQDRECGYRENVSRFTNVRCPECHVKLELRGEGQGQIYVCTRCSFREKLSSFNKKYRNNQEKLNKRDVTKYMKKMQKENDEPINSALAEALSKLKL
(748) DNA topoisomerase 3 [Clostridium cellulolyticum H10]
2
MGFTLILAEKPSVARDLAKVLNCGQNANGYIMGKKYIVTWALGHLVTLADPEAYGNKYKTWNLEDLPMLPNKMELVVIKQTAKQYGVVRGLLNRADVDELVIATDSGREGELVARWIIMKAGFKKPIKRLWISSQTDKAIKEGFAKLRPSKEYDNLYYSAQSRAEADWLIGLNVTRALTCKYNAQLSAGRVQTPTLAMIVEREEEIRKFRPKDYWTISAQFNGFTVQWQDSRNNQTRTFNKEEADGIVAKITGQMGEVVEVKKETKKELPPLAYDLTELQRDANKKFSYSAKQTLNIMQRLYESHKLVTYPRTDSRYITDDIVPTLNERLKSIAVGPYAKLVQGVMRNKPSVTKRFVDNSKVTDHHAIIPTEQFVDLFSLNSEERNIYDLIVKRFIAVLSKPFEYEQTTVKLDIAGESFYAKGKIVKSSGWKTVYDGFGKLDEDDEDDNDQSLPDIQKGHKAKVVGPKSINGKTKPPARYTEATLLSAMEHPGKFVDNKALKEALESTSGLGTPATRADIIEKLFNTFYIERKGKEIYPTSKGTQLISLVPTDLKSPELTAKWEQQLTLISKGKVNSNVFVNDMKKYARKLVGAVIASSEQFKHDNVTREKCPECGKYLLEVNGKKGKMHICPDRECGYRKSVTVISNARCPECHKKMEIRGEGENKSFYCSCGYREKLDAFKKRKGQQVDKREVAKFMRQQEKDENINSALADALAKWKNN
(1178) DNA topoisomerase 1 [Clostridium cellulolyticum H10]
1
MADNLVIVESPGKVKSISKFLGKGYKVEASVGHVRDLPKSQMGVDIDNDFEPKYITIRGKGDVISKLKKEAKAAKKVFLATDPDREGEAISWHLAKILNIDEKQKCRVSFNEITQNAVKNAIKQPRTIDMGLVDAQQARRVLDRIVGYKISPLLWKKVRKGLSAGRVQSVATKMICDREDEIEKFESQEYWSIIAKLVKPKASPNFGAKFYGIGKEKLELTNEEQVNSILEEINKSQYIVQKVKEQEKKRAAAAPFITSTLQQEASRKLGYTTKRTMMVAQQLYEGIEIKGRGSVGLITYMRTDSTRISTDAQNEAREYIKTKYGQDYIPEKPREYKNKSASQDAHEAIRPTYIDLPHEQIKEYLSPEQYKLYRLIWDRFISSQMSSAIYDTVSADITAGKYLFKANGSKVKFPGFMVLYTEGNDNEGKDEAEQDEKENKLPQLNEGDILELKENTPKQHFTQPPARYTEATLVRALEEKGIGRPSTYAPTITTILSRGYVLKEKKLLVPTELGKIVNDIMKNHFENIVDTKFTAEMESELDSVEDGDKEWKAVMRDFYSSFAGVLKKAEESIGDVELPVEVSDVQCDKCGRYMVVKHGRFGKFLACPGFPECRNAKPIVEEAGVECPICKGKVLIKKTKKGRKYIGCEKNPECPFMSWDMPSPNKEVCSVCGSFMLQKFSGKKKVLKCSNDKCTSNIEASKDNTK
(261) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-mouse-Japan]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVSVEDDYEPNYINVRGKADLIKSLKKASKKSEKVFLATDPDREGEAISWHLAYILGIDVDDKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINSFEVKQYFTIEGSGKKNSKKYVFKLHSKHKEKLDELTENKVLEILDELSEGKYIVDEIKEGSKNKYPSPPFTTSTLQQEAYKKLNFQTKRTMSVAQSLYEGVEVKGYGVVGLITYMRTDSVRLSADSLNQANEFVAKVYGDKYKLDIPRQYGKNNKNIQDAHEAIRPTNVEITPDIAKQTLKDDQYKLYSLIWRRFLASQMRNAVYNTMAISIKNGDYLFKLNGSQLQFDGFLKVYEVDKDDKDLILPAFEEGEELKNVKVESIEHFTQPPPRYTEASFVKLLEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIEFTADMEKKLDGIEEGKASWKSIVHEFYKPLKEKIDIAENTVKKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSIIQKLNIPCPKCGGEINVRKSKKGKVFYGCSKYPECDFISWNEPSNVKCPKCGGITVKKIKRKQEFYECIDQDCKDK
(1023) DNA topoisomerase 1 [Candidatus Arthromitus sp. SFB-rat-Yit]
1
MAKYLVIVESPAKAKTIKKYLGLNYEVVASMGHIRDLPKSRLGVNIEDDYEPNYINVRGKADLIKSLKKYSKKSEKVFLATDPDREGEAISWHLAYILGIDLSEKCRVEFNEITKTTIKNSIKNARSINLNLVNAQQARRVVDRLVGYGISPILWKTVKPKLSAGRVQSAALKLICDRENEINNFEVKQYFTIEGTGRKNSKKYVFKLHSKNKEKLDELTKDRVSEILDDLSKGKYVVDEVKEGIKNKYPLPPFTTSTLQQDAYKKLNFQTKKTMSVAQSLYEGVDIKGYGVVGLITYMRTDSVRLSSDSLNQANEFVKKVYGDKYKLDKPRQYGKNNKNIQDAHEAIRPTNVEITPEIAKQTLKDDQYKLYSLIWKRFLASQMANAVYNTMSISIKNNGYLFKLSGSQLKFDGFLKVYEIDKDDKDLILPIFEEGEELNNIKIESVEHFTQPPSRYTEASFVKLMEEKSIGRPSTYVPTISTLFDRMYLKRQNKQFVPTELGIIVNDLIKNNFTEIVDIDFTADMEKKLDGIEEGKVDWKNIVHEFYKPLKEKIDIAENTVEKVVIEDEVTDVLCDKCGRNMVKKHSRYGVFLACPGYPECKNTKSITQKLNVSCPKCGGEINVRKSKKGKVFYGCNNYPECDFVSWNEPSDVKCSRCGGITVKKIKRKQEVYECIDENCKE
(1074) DNA topoisomerase [Clostridium kluyveri DSM 555]
3
MKLILAEKPSLALNIVKSIGNMNRNDGYFENRDYLITFAYGHLLRLYDVDNYFKRGKTKWNLDELPFVPEDFKFKIREDKGVKKQYEVIKNLIRRNDVTEIVNCGDADREGEVIVNNIISRIFKEENINKPVKRLWLPEQTTQTIRQELRNLKDNRDYKNLYNEGLARTYLDWTYGINLTRYLSIKSQTFLPVGRVLIPIVKFIYDRDRAIENFKPETYFEIGAVIKKDNLEIKAKLKDRRFSADEREKAANLLNSLKDKKAIVDKVEKKKVKKQPPKLFSLDTLQNKMFKQFKMSLDDTLKHLQKLYECGFTTYPRTNTEYLAENEKGKIKSIIEVMKEKFNVDIDFKDKKKIFDNNKVESHSAITPTTKIPEIEKLSEDEKKVYTAIRNRFISNFLNEETIIEETYVIIRIVDEVIELKGNVIKQTGFLKYENIKKENELPDFVEDEKLDTKLSVDEKQTQKPNRVTESELNNFLKNPFKKKEIQDLENTNDDEEYKMILEGCEIGTVATRAVIIKNAQKYEYIKEVKGHFECENKGIRLIDVLKRLNIDLDKGKTVEFGKQLKGVYKNDIEINTIIYNVKSELNNIIRKGDEIKIDRIESKKYESMGVCPICGKGNIMANKFGYGCSRWREGCKFFIGKQIAGKNISESMAKKLIKNKKTNVIKGFKSKNGKSFDAVLTIKDENVAFDFSSESKGLGTCPVCGKGNVIANKSGYGCDKWKEGCKFFIGSKIASKSITESMVKKLLKDKKTNLIKGFKSKNGEVFDAFLIIKDSKIVFDFKE
(878) DNA topoisomerase 3 [Clostridium kluyveri DSM 555]
2
MSKILVLAEKPSVGRDLAKVLHCNKKNLGYIEGDKYVVTWALGHLVTLADPEDYDERYKSWVLEDLPMLPDKLKLVVIKQSGKQFNIVKSQMNRKDIGEIIIATDSGREGELVARWIIEKARVKKTVKRLWISSQTDKAIKEGFANLKNSSKYDNLYKAARCRAEADWVVGLNITRALTCKYNAQLTAGRVQSATLAMIVNREEEIKNFKAKDYFVINAKTKEFTLMWRDKNNNSNIYEENRVNKILAITKGKAANIIDVRESYKKQYAPALYDLTELQRDANRIFGYSAKHTLSIMQRLYENYKILTYPRTDSRYISTDIVDTLKERLKAISVGSYKIYASELLKTRINAHKGFVDNSKVSDHHAIIPTEEVLTLSLLSSEEKNIYDLVVKRFLAVMLPPFEYVQTSIITDINGENFIARGKVVKSKGWKKVYDIGNQVIEDDENENQILPELKKGDSIDIISIESRRLKTKPPARFNEGTLLSAMEKPQKYISIDKLYAKTLGETGGIGTVATRADIIEKLFNMFYVEKNGKDIIPTSKGKQLIELVPEDLKSPLLTAQWEMDLELISKGKKDPEVFIRKMREYAGTLVEDVKESSNKFKHDNITGKKCPVCGKYMLEVKGKQGRMLVCQDRECGHRENLARLTNARCPECHKKLELKGEGEKRIYVCSHCSFREKFSSFNKRFKENEGKLNKKEVSKYMKKMNGENKANINSSLAEALANIKFK
(714) DNA topoisomerase 3 [Alkaliphilus oremlandii OhILAs]
2
MYHHRIERIVNMNKKLVLAEKPSVGRDLARVLNCNKKGNGYLEGQEYIVTWALGHLVTLADPENYSDRYKSWKIEDLPILPSDLKLVVIKKTGKQFQTIKEQMHRKDVNEIIIATDAGREGELVARWIIEKAKVQKPIQRLWISSVTDNAIKDGFKKLKNGKDYEKLYQSAVARAEVDWIVGINATRALTCKYNAQLSCGRVQTPTLAIIAQREAEIQNFKSRTFYGMEAMSPHLKLTWQDRKTKDIRSFEKEKITSILNAIKNKDGYVMDVEKKYKKSYAPKLYDLTELQRDANRIFGYSAKETLGIMQQLYENYKILTYPRTDSRYITSDIVPTLKDRIKACGVGPYKLAANKVLQGSIKGNSSFVDDGKVSDHHAIIPTEQFVQLSSLSDKERKVYDLVVKRFLAVLYPPFEYEETFIRAKIGEEVFIAKGKNVIHQGWKEVYGNMDEDESGNEDISEQLLPRVNKGDVLKISSITQTTGQTKPPAPFNEGTLLSAMENPVKYMKDAHKDLIKTIGETGGLGTVATRADIIEKLFSTFLIEKRGNDIWITSKGKQLLELVPEDLKSPALTADWEQKLGAISKGDLHRDHFVKEMKAYTKTVVDEIKNSDETFKHDNLTRNKCPECGKYMLEVKGKRGKMLVCQSRECGYRKGVTQNTNARCPNCHKKLELRGEGEGQIFVCSCGHREKLATFKERKKQEGSKVSKKEVVKYMNQQKKENDGFANTALADALSKLKF
(1871) DNA topoisomerase [Alkaliphilus oremlandii OhILAs]
7
MKRLVIAEKPSVAKDIAKVLNCKEKREGYIEGSDYIITWAIGHLVILCDPEEYDIRYKKWDFNTLPIIPDKIKLKPNPKTYKQYQIVKALMLSSQIDEIICATDAGREGELIFRYIYELAKCRKPFQRLWISSLTDEGIRTGFEHLKDGKAYDALYYSAKCRSESDWLVGINGSRAYSIQYGSLLPIGRVQTPTLKIIVDRDLEIDDFVPKDYWEVKADFGNYSGIWIDLEKNESKIDSIQKAEDIKNKVLLKEGLVTDFQKKKVVKKPPFLYDLTELQRDSNKKFGYTAQRTLDIAQSLYEKRKAITYPRTDSRFLTKDIIPKLKSLINKIGLEGYKEFTSILEKLEKLPVNPRIINDRKVTDHHAIIPTEKKIDLNKFSEEEKNLYDLIARRFLAVFYPDYEYFSIVMITHVAGEDFKSNEQQTIHLGWKLLYSDKEVETKESTLIHIKKGSSSTLKSAEIEQKQTKPPARYNEALLLDSMENAGKFIEDEELKEQLKSSGIGTPATRASIIERIISVGYVERKGKNLISTEKGRKLIQITSQELSSPELTGKWEKALDKIAKGNMNPQRFMEGIGRFTKFIIEDVQKNTKNVVFEGYSKNRGKKSSGTSSYNSPIGICPACKVGKVLEGPKNFYCSEYKQGCKFGIFKEDILMKKFKKKMTKTMVSKLITNQVVTVKGMVSPKTNGKFDGNICLKQSSNGYWGWEFTNGGVNN
(857) DNA topoisomerase 1 [Alkaliphilus oremlandii OhILAs]
1
MTKSLVIVESPAKAKTIEKFLGKNYVVKASVGHIIDLPKSKLGVDIDNNFEPQYITIRGKGPVLKEIKTLAKKSKNVYLATDPDREGEAISWHLARALGIEASDDCRIEFNEITKNAIKSAIKKPRPINQDLVDAQQARRVLDRLVGYQISPLLWKNVRKGLSAGRVQSVATKLIIDREEEIKNFKPEEYWTLSLKIKTKNNENFEIKFQNDNLGNKEIHTEAEVDRILNHIQNHEAIVTSVKKGEKKRNPNLPFTTSTLQQEAANKLGFSTKKTMSLAQQLYEGIDIGKSGTVGLISYIRTDSTRISQESSESCKNYIHENIGESYYHSETKERKENKGKKNIQDAHEGIRPTDVYRHPDLIKGFLSKDQYTLYKLIWQRFVASQMAPAVYDTLNVEFDINKVIFKATGSILRFEGFLKVYSYANVSENINIPDLAEGEVVTVLEQMPKQHFTQPPGRYSEATLVKTMEDLGIGRPSTYSPTISTILSRGYVEKEGKSLTATELGYIINEILEDYFSKIIDTNFTAKLEQSLDYIEEGTQDWKKLISEFYEDFKVMLLNAEEHMEEINLVEESDEKCSKCDSVMLIKHGRYGKFLACSNYPECEETKPFLYKIGVSCPKCESGDVIEKRSKKGRLFYGCSTFPDCRFVSWNRPTGKKCPTCGDILVYKKTKKSEKNICINKECGFEEEIEN
(1430) DNA topoisomerase 1 [Alkaliphilus metalliredigens QYMF]
1
MAKSLVIVESPAKAKTIEKFLGKRNYIVKASVGHVIDLPKSKLGVDIDKDYEPQYITIRGKGPVLKEIRTEAKKAKRIYLATDPDREGEAISWHLANALNIDKNEACRIEFNEITKNAIKSAIKTPRKINHDLVDAQQARRVLDRLVGYKISPLLWQKIRRGLSAGRVQSVATKMIKDREVEINAFQPEEYWSLILQVQNMQKEKFEVKFQSDHLGNKDIKSEDEINIIINKIKDKQLMITEVKQGEKKRNPSLPFTTSTLQQEASNKLGYSTKKTMSLAQQLYEGIELGKEGSVGLVTYIRTDSTRISEEASQHVAQYITEKIGEHYLQKSTIVKKGKKSVQDAHEAIRPTDVTRSPDVMKPYLKKDQYKLYKLIWERFVASRMEPALFDTLSITLDVEGVTFKANGSRLRFEGFLKVYSLASRSEDTDLPVLNKDELTSIVEIDPKQHFTQPPPRYTEASLVRAMEEQGIGRPSTYSPTIATILSRGYVEREGRNLLPTELGILVTGILEDFFSQIIDVHFSAELENQLDEIEEGKKGWKSLIEDFYPSFEEMLKVAEEHIEEIHLVEESDEICDQCDAPMVIKHGRYGKFLACSSYPDCTFTKPIVHKIDVKCPKCEDGEIVERKSKKGRLFYGCSGFPSCRFVSWAKPINEKCPQCNEILAHKKTKKSEKITCTNSECKYERLIEDENEK
(697) DNA topoisomerase [Alkaliphilus metalliredigens QYMF]
3
MSKSLYIAEKPSVALEFAKTLNIKGNKKDGFIESNEAVVTWCIGHLVTMSYPDKYDDKYKKWVLKDLPFLPNKYKYEVIKNVKKQFDIIKTLMKRTDISTIYVCTDSGREGEYIYRLVDEMVNVKGKTKKRVWIDSQTEEEIKKGVKNAKPLDEYDNLANAAYLRAKEDYLMGINFSRLLTLSYGSALSKRLGKKYVVIAVGRVMTCVLGMVVQREREIREFVKTPYYKIISNFQLDQSMDYDGEWKAIESSNYYMSDLLYKDIGFKEVKSAEKFIRELKEDNTELTAVVETIKKKKETKNPPLLYNLAELQNELSKKLKINPDETLKVAQKLYEKKMITYPRTDARVLSNAVAKEIHSNLKGLLRVKQSCQLEPGDEGINDFIQKIVNEGLYKELQKTKYVNDKAITDHYAIIPTGEGLGSFNRLTDYEKETFLLIVRRFLAIFYPPAIFSQLSITTKIKTESFFTTSKVCIQEGYLEILNDGKKDGASSLDKEETLKKLKKGQTVKINKLEIKESETTPPKRYSSGSIILAMESAGKLIEDEELREKIKGSGIGTSATRSGILNKLQQISYIALNKKTQILTPTSLGESIYDVVDESIPSLLKPELTASWEKGLGMIANGEIQCDEYMIKLEAYIRKNTQKVLKLSNQPNLLNSRSIKSTTNKGNQDTKGKRVGRLALGKCIACETGEVLENSKAFYCSNWKQNCKFTVWKDSLKRYEQEIDEEMIKALLEKGQIDKVSIVLPQTNEKCTASLEFKDNKKGELQLKNVTPTTE
(354) DNA topoisomerase 3 [Alkaliphilus metalliredigens QYMF]
2
MKKKLVLAEKPSVGRDLARVLNCNQKGNGYLEGKEYIVTWALGHLVTLADPETYSQKYKSWKLEDLPMLPDEMKLVVIQKTGKQFNAVKSQMVRKDVGEIIIATDAGREGELVARWIIEKVGVKKTIKRLWISSVTDKAIKDGFNKLKNGREYDNLYASAVARSEADWIVGLNATRALTTKYNSQLSCGRVQTPTLTIIAKREEEIQRFQPKTFYGAQVVAGDLKLTWQDQQTNSMRVFDETKIDQVIQSIQNQEVKVVDISKRHKKSYAPRLYDLTELQRDANKIFGYSAKETLSIMQKLYETHKALTYPRTDSRYITADIVGTLKDRLQACGVGPYKAFAAKVMQSSIKANKSFVDDAQVSDHHAIIPTEQSIYLGALSDQERKIYDLVVKRFLAVLYPPFEYEERTINAKLGKEHFIAKGKMVIHQGWKAIYGHQTEVSEDEDIADQILPNLNRGDTLKVNAISKTTGKTKPPALFTEGTLLTAMENPSKFMSNEDKTLIKTIGETGGLGTVATRADIIEKLFSSFSIEKRGKDIHITSKGKQLLQLVPEDLKSPGLTAEWEQNLSAIAKGKLNKNTFVNRMKEYTKTIVKEIKNSEAAFRHDNLTANKCPDCGKYMLEVNGKKGKMLVCQDRECGHRKIVAQKSNARCPDCKKKLELRGEGEAQIFVCSCGHREKLSTFKERRKKDQDKASKGEVNQYLKQQKKEEPINTALADALAKLKLD
(209) DNA topoisomerase 1 [Clostridium thermocellum ATCC 27405]
1
MADKLIIVESPAKAHTIGKFLGKDYKIVASVGHVRDLPKSQMGVDIENDFTPKYITIRGKGEIISKLKKEAKNASTIYLATDPDREGEAISWHLATLLNIDKNEKCRITFNEITKNAVKNAIKSPREINMDLVDAQQARRVLDRIVGYKISPLLWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTITAKLLKGGVKAPFEAKFYGLDNKKTELKSEEEVNKVLDEIKDAVFVVQKVKKGEKKKNPNAPFTTSTMQQEASRKLGFSTKKTMMVAQQLYEGIEVKGVGAVGLVTYIRTDSTRISEEAQNQAAKYIKEKFGESYLPKEKNVYKNKSASQDAHECIRPTSVEMDPESVKDSLTKEQYRLYKLIWDRFVASQMAPAVYDTINADIEAGKYLFKASGSTVKFPGFTVLYQEDKDDETEEGEVIVPELAEGESLKLKKLEPRQHFTQPPPRYTEASLVKALEEKGIGRPSTYAPIITTILARGYVVKEGKTLVPTELGKIVTDIMKNYFQDIVDVEFTAQMEKTLDEVEEGEKRWVDVMRSFYSQFVDVLKNAEEKIGNIEVPEEVTDEICEKCGRNMVIKVGKKGRFLACPGFPECRNAKPILEDAGVTCPKCGGKVYIKKTRKGRKYLGCENNNSDPKCDFMTWDMPSKENCPKCGSFLLKKYSGRKVQLKCSNENCDYVKTGKEKKEDE
(1294) DNA topoisomerase 3 [Clostridium beijerinckii NCIMB 8052]
2
MSKTLVLAEKPSVGRDLAKVLKCNQNKGSYIEGSKYIVTWAMGHLVGLMDPEGYDNKYKEWKMETLPMLPKHMKLTVLKKTGRQYNEVKKQLLRNDVSDIVIATDAGREGELVARWILEKSGVKKPLKRLWISSQTEKAILDGFRNLKPGAAYENLYKAAVCRAEADWLVGLNVTRALTCKYNAQLSAGRVQSPTLSMIVLREDEIRNFKPKTYYTLEGKTRGFNLAWVNKDNNSRIFDEEFANKVASKLKNSEGKIVNINEANKKKFSPALYDLTELQRDANKIWGYSAKQTLNIMQRLYENYKILTYPRTDSRYITTDIVATIPDRLKAISIGEYRIVAEELLKGKIIGNKSFVDNSKVSDHHAIIPTEQKPNLALLSSEERKIYDLVVKRFLSVMLPPFEYIQTTIEAEVQGEKLVAKGKVIKAKGWKKLYDRLEEDSDEEEIKEQVLPTVSIGNSIRVESVNIKKGETKPPARFTEATLLSAMESPHKYINVSKEAAKTLGETGGLGTVATRADIIEKLFNSFVIEKKGKEIIPTSKGKQLMELVPKDLKSPLLTAKWESQLDEISKGKRDDHSFIKEMKNYSVALVEDVKGTNNKFVHDNKTGKKCPNCGKYLLEVKGKNGVMNVCQDRECGYRESVARVTNARCPECKKKLELRGNGEGAIYVCPGSNCNFREKASQFKKRFEKNGKIDKREVNNYMKKMKKEAEEFDDNPFAALLGDIKFDK
(975) DNA topoisomerase 1 [Clostridium beijerinckii NCIMB 8052]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIENNYTPKYITIRGKGELIDKLRKAAKKAEKVYLATDPDREGEAISWHLANILKISEDETCRIVFNEVTKTAVKASIKQARKIDLDLVDAQQARRILDRLVGYEISPILWKNVKWGLSAGRVQSAALKLICDREKEINEFIPKEYWSIDCTLKKEKKKFPVRLSTYKGKKIEIGNEETSNGIIKELNKGNFVVKSIKKGKKNRNPLPPFTTSTLQQDANRKLNFMTKRTMSIAQVLYEGVEVKNYGTVGLITYMRTDSVRISEEAQESAKEFIEGSYGKEYLPGAPRVYKGKKNIQDAHEAIRPTYVEITPEIAKENLTPEQYKLYSLIWNRFVASQMASCELNTHSIDIENGDYKFKASGSVISFDGFMKIYEYSNEEDENSVMLPELKENEELKVESLNGTQHFTQPQPRYTEASFVKLLEEKGIGRPSTYVPTISTLLGRNYVIREKKNLIPTELGEIVNNIVSEYFRQIVDVDFTADMERKLDDVEEGSENWTQIVEEFFSPLKVAIEKAEKEISKVVIEDKVSDVKCEKCGRMMVIKRGRFGEFLACPGYPECKNAKPIVEELDVPCPECGKPIVAKKSKKGKKFFGCLGYPECKFVSWYEPVKEKCPNCNSYMVAKYSKTKGNYIQCSNSECNYKEEVKKDNSKEE
(1168) DNA topoisomerase [Clostridium beijerinckii NCIMB 8052]
3
MAKVIIAEKPSVAKNIADAFNVKTRRDGYFEGNGYYITWAFGHLLQLYDAKDYDENMKGWRFEKFPFIPEHFLYKVKCDSVDRTVEDKGAKKQLGIIKSLIDKEDVDGIVSATDFDREGQVIADELFGYFKVKKPIYRLLLNEWTPDEVKSGMESLKDNKEMQPLQDAGIGRQWSDWIIGINLTSVSTLKYKFEENKTINIGRVLLPTLKIIYDRDKEIENFTATTYYKLVSNFKTSANEEFEGLYYENDSEKFEKKEDLDKFISRLEGATAKIIDKQTELKKEYPPYLFNLSNLQGHITSKYKGWTSDKVLKVAQSLYEKKLTTYPRTASVVLEESLKDRAKKVLNTLKAGLPYEKDIKFSTSKRIFDSSKVESHSAITPTYIKPSGLSSDEKIVYDAIKNRFIMQFMPIAEFEETKVTLKANVSEMNGIFVSKGKVKLVEGWKVVEKIESKDVILPKIEIDETVDIVDSKVNSVTKKPPKYHTEKTLLRVMETCGKGIEGKDEDSEEMMQAILSGFSIGTPATRAETIKKLKDIGYLKTKGKNLMCTELGRNLVETFPVKELFDLEYTGRLEKTLSDIEKGKFAKSEFIKLITDFTIQSVELIKKDDAALSRFKVEIPKDSENIGPCPVCGNPVIEGEKSFGCSNWKNGCKYTIWKDDRYIASFGKKISKEMVELLLKNGKVGFRNLKSKKGNTFSAYFKYEKNEESGYFNWKIEFIDNK
(861) DNA topoisomerase 1 [Clostridium cellulovorans 743B]
1
MGTNLVIVESPAKAKTIRKYLGKNYVVEASMGHVRDLPKSQTGVDVENNYEPKYITIRGKGELLDKLRKQAKKSEKIYLATDPDREGEAISWHLSKVLKLSETEKCRIEFNEITKTAIKAAIKSPREINMNLVDAQQARRVLDRLVGYGISPILWRKVKWGLSAGRVQSATLRMICERDKKIKEFIPKEYWTIEGIFNSTDDTKNSKEKLNLKLHNFKNEKIEIDTKEKADEILNIIKSGNYTVSKVKKTERIKNPLPPFITSTLQQDAYRKLNFTTKRTMSIAQQLYEGIEIKGKGSVALITYMRTDSVRISDEAQKSALEFINTSYGTEYVPSEPRIYKGKKNIQDAHEAIRPTYIDITPDKIKGDVKDEIYKLYKLIWERFVASQMKSCVLDTVSVTVDNSGYNFKANGSTVKFDGFMKIYSYGTEGDESLTTIPKVQEGEMLSCIQIDGLQHFTEPPARFSEASLVKTLEENGIGRPSTYAPTIATLLSRKYIEREKKTLVPTELGIIVDNIMCEFFNQIVDEEFTANMEERLDDIELGDSDWRKIVNEFFTPVKAEIEKAEIELAKITIEDEVTDIQCEKCGRNMVIKHGKFGDFLACPGYPECENTKPIVEEIDTPCPKCGSKIVVKKSKKGRKFFGCSTYPNCDYVSWYEPSSKKCNQCGSIMLKKYNKTNGNYLECSNSDCKSKEIIQEETE
(274) DNA topoisomerase type IA central domain protein [Clostridium cellulovorans 743B]
3
MSKVIIAEKPSVAKNIAEALKSNIRKDGYLEGNGYYITWAFGHLLQLYDAKDYDEKMAKWKMDNFPFIPKAFKYKVKNDSKKKDKPDAGAKKQLKIIEELINRNDVDMVISACDYDREGQIIGDIITGYLKVKKPVYRLLQNEWTADEVIKGMEKIKPNTEMKSLRDAGISRQWADWTIGINLTSVATLKYQRGKGNPLNIGRVLLPTLKIIYDRDKEIANFVPDNYFKLNATFKTSDNIEYEGAYIEKEQEKEQEKFKEREKLDEISKKMKGCTGVIVDKQTEKKKEYPPYLFNLSNLQGYITSKYKGWTSDKVLKVAQGLYEKKYITYPRTASVVLEESLADRAAKVLNTLKKSLPFQEEVKFIKNKRIFDNSKVESHSAIIPTYLEPKTLSGDEEKVYSAIKNRFIAQFMPIAESEETKIFTRIKNFDLDGIFISKGKVQIVEGWKKVEKIESKDTILPFVNINDEVDTIKTKVSAHSTKPPKRHTEKTLLRVMETCGKKFDEEQSDQMMDAILSGFSIGTPATRAETIKKLKDIGYIYTEGKNLICSELGVKLVETFPIQELFDLEYTGRLEKTLADMEKGKVEKEDFLKLIFDFTTNAINQIKGDKENVINQYEGELVKGESLGKCPCCGNDVIEGKIGFGCSNWRSGCKYVVWKEDKFLMSMGKKITKDMVMSLLADGKVAIKGLKSRKGNIFDASLSYEKNKDNDYFSWKMEFLNSQESKNRT
(756) DNA topoisomerase 3 [Clostridium cellulovorans 743B]
2
MSKTVVLAEKPSVGREIARVLKCTKSGNGYIEGPKYIVTWALGHLVTLADPEVYDDKYKSWRLEDLPMLPKPLKLVTIKQSGKQFNAVKEQLNRKDVDEIVIATDAGREGELVARWIIEKARVKKPMKRLWISSQTDKAILDGFRNLKPSAQYENLYRAAQCRAEADWVVGLNVTRALTCKYNAQLTAGRVQSATLAMIVSREEEIRTFVPKDYFVINAKAKGFNLQYRDKNNNSNIFEVDKVNKVLSAVRGKEANIVEVTESYKKQYSPALYDLTELQRDANRIYGYSAKQTLSIMQRLYENYKVLTYPRTDSRYLSTDIVATLPDRLRAIAVGSYSAVANEILKGKITGHKGFVDNSKVSDHHAIIPTEEKGKLALLSSEERHIYDLVVKRFLAVMLPPYEYLQTTIKADINGETFVAKGNVIKAKGWKKVYDKEATLAEDEDDKDSQTLPVVKKGDKLNVMSIDSEKHKTKPPARFNEGTLLSAMEKPQKYVSLDKVHAKTLGETGGIGTVATRADIIEKLFNMFYIEKNGKDIIPTSKGKQVIDLVPSELKSPLLTAEWELELERISKGQKDSRGFIEAMRKYAAELVDDVKGSSDKFKHDNLTGKKCPDCGKYMLEVKGKQGRMLVCQDRECGHRENLARITNARCPECKKKLELRGQGEGKIYVCPGSNCNFREKASQFEKRFDSKSDKLNKREVAKIMNKLNQEKEDPMDSPFADLMNMFKDKK
(979) DNA topoisomerase 1 [Clostridium cf. saccharolyticum K10]
1
MAKNLVIVESPAKVKTIKKFLGSNYEVDASNGHVRDMPKSQMGIDIEHGYEPKYITIRGKGDILAKLRKEVKKADKIYLATDPDREGEAISWHLSKALKLEDCKDKKVYRITFNEITKNAVKAALKTPRAIDMNLVDAQQARRVLDRMIGYRISPLLWAKVKRGLSAGRVQSVALRMICDREEEISSFIPEEYWNLEAKLKAKGSKKKLTAKFYGTREGRMAIHKKEELEAVTAALEGAQYTVDEVKTGERVKKAPIPFTTSTLQQEASKTLNFSTQKTMRLAQQLYEGVDIEGKGTIGLITYLRTDSTRVAEEADKTAREFIEEKYGKQYVSTEEAVKKGGAKIQDAHEAIRPTDISLTPAVVKESLARDLFRLYQLIWKRFAASRMQAAVYETTSVRVAAGYAGGEYLFTLSASKLKFDGFMSVYVQEDEKEESTVLSEKLEKGDVLACEALESSQHFTQPPAHYTEASLVKALEEQGIGRPSTYAPTITTILARRYVVKENKNLYVTELGEVVNRMMKKAFPSIVDTAFTANMEYLLDRIGDGTVQWKTVIENFYPDLEEAVKEAEKKLEAVKIADEVSDVPCDLCGRMMVIKYGPHGKFLACPGFPECRNTKPYLEKIGVACPKCGKEIVIRKTKKGRKYYGCENNPECDFMSWQKPSAERCPECGGLMVEKGNKLLCTNKECGYVKTKENRQQQE
(633) DNA topoisomerase [Clostridium cf. saccharolyticum K10]
7
MKLVIAEKPSVGAAIAAVLGANEKRSGYFEGSGYLVSWCIGHLISLADAATYNEQYRKWKYDDLPIVPQDWQFTVASGKEQQFSVLKDLMHRSDVSEIVNACDSGREGELIFRFVYEQANCKKPFSRLWISSMEESAIREGFSNLKDGRSYDDLYQSALCRAKADWLVGINATRLFSILYHKTLNVGRVQTPTLTMLVNRDYAISSFKKEKYHVVRLNAGGVSALSERLNDEAAAQQMKAACEKSQAVCTSLKKEKKTVSPPKLFDLTALQREANRLYGFTAKQTLDYAQALYEKRLLTYPRTDSKYITSDMQDSTKELITGLCSLLPFMRDVKLQADLTRVCDNSKVTDHHAILPTAEFLKAGFSSLADSETKLMTLVCAKLLCAAAAPYEYEAVTAAISCGGYTFTAKGKTTLCEGWCEIEKLSRAASEEQDEDAEPETVLPPLAEGQTFDNPAAEISERYTQPPKAYTEDTLLSAMENAGKEETPEDAERKGLGTTATRAGIIEKLISAGFAERKGKKLIPTKDGYNLAAILPEVLTSPQLTAEWETRLTGIAKGSDSPDDFMRSIEEMTAGLVKTYSAISEDKAKLFTPQREAIGTCPRCGAAVYEGKKNYYCSDRACSFVMWKNDLFFQQRKKTFTKAIAAALLKDRKVKIKGMYSTKTGKTFDGVVLLADTGGKYVNFRVEQNRK
(1740) DNA topoisomerase III, bacteria and conjugative plasmid [Clostridium cf. saccharolyticum K10]
7
MRLVIAEKPSVAKSLATVLGAATRKDGYLEGNGWLVSWCLGHLAGLADAATYNPDYAKWRYDDLPILPETWRFTIAKDKRDQFDVLRTLLRREDVTEVVNACDAGREGELIFRTVYCLAGCQKPMKRLWISSMEDSAIREGFAHLRPGADYDGLHQAALCRAKADWLVGINATRLFSVLYHRTLNIGRVMSPTLALIVQREAEIDAFKPVPFYTVALDLPGFTAASARMDKKADAEQLKNACQSGTVTVKQVARRDKSEKPPALYDLTTLQRDANRLLGFTAQQTLDYLQNLYEKKLCTYPRTDSRYLTSDMAEGLPVLVNLVANAMPFRKGIAISCDAAAVINDKKVTDHHAVIPTRNIREADLSALPVGERAILELVALRLLCAVAHPYIYDETSVTVECAGAEFTAKGRTVKQPGWRALDAAYRASMKNAEPDKETEDKALPELAEGQELPVAGAAVKEGKTTPPKHFTEDTLLSAMETAGAKDMPEDAERKGLGTPATRAGILEKLVSTGFLERKKSKKTVQLLPSHDAISLITVLPEQLQSPLLTAEWEYRLGEIERGELAPEDFMAEITAMLKELVGTYQVIKGSEYLFAPPREVVGKCPRCGGEIAEMQKGFFCQDKSCKFAIWKNSKWWAAKRKQPTKAIVAALLKDGRARVTGLYSEKSGKTYDATVVLEDTGQYVNFKLEFDRQKGGGK
(871) DNA topoisomerase [Clostridium cf. saccharolyticum K10]
3
MAKALYIAEKPSVAQEFANALKISGRRADGYIESETAVVTWCVGHLVTMSYPEEYDIKYKRWSLETLPFLPAEFKYQVIDGVKKQFQTVSTLLNRSDIDTIYVCTDSGREGEYIYRLVAQMAGVHGKKEKRVWIDSQTEEEILRGIREAKELKEYDNLAASAYLRAKEDYLMGINFSRALTLKYGPSISSFLRSKWTVVSVGRVMTCVLGMVVRREREIRNFVKTPFYRVIGTFTRESMKISAEWRAVQGSRYFQSPFLYRENGFKEREKAEELIAWLSAEGPVTGTVFSVEKKKETKNPPLLYNLAELQNDCSKMFKISPDQTLKIVQELYERKLVTYPRTDARVLSTAVAKEIGKNLSGLKGFSPCASFAAEVLQGTAWKTIAKTRYVNDKQITDHYAIIPTGQTGAVRNLPSLNAKVYELIVRRFLSIFYPPAVYRKYSLEIAAKTEHFFANFKILKEPGYLKVADVSGIRKKDENAEGTKDTAGAAGESSGEQSAGDSRQEETVIGDEAFAAMLEKLKKGMTLDLSGLAIKEGETSPPKRYTSGSMILAMENAGQLIEDEELRAQIKGSGIGTSATRAEILKKLMSISYLSLNPKTQVITPTLLGELIYEVVNASIRQLLNPELTASWEKGLTYVAEGSITEKEYMEKLERFVAGRTYGAVHTANQAGLRRQFELAAASYKGAEKLPGKGAASAEKAGKNVKNSRKKSAKTGGTINEKN
(268) DNA topoisomerase 3 [Clostridium cf. saccharolyticum K10]
2
MKSLVIAEKPSVGKDIARVLGCRKSADGCLEGDKYIVTWAFGHLVELAAPEEYDKKYKDWNMADLPMMPEPFKLEVIGKTAKQFGVVKRQLFRNDVKDIVIATDAGREGELVARFILMKAGCRKPLKRLWISSVTDRAIKEGFSRLRDGREYNHLRDAAMCRAEADWLVGLNATRALTCKYNAQLSCGRVQTPTLAIIAKREEEIRNFRPKAYWGLTARTSKPALTLTWQDKKSGGMRSFDRDRMEGLQKSLRDQQVRITKVKKTPKKTMAPLLYDLTELQRDANKRFGYSAKETLNIMQRLYENHKVLTYPRTDSRYLSSDVADTIHDRLAACGTGPYRKLAGKLSKNVWTKKASFINDGKVTDHHAIIPTEQFVQLQNMTSEERKIYDLVVRRFLAVLYPAAEYDETVITAEIGGEIFTARGKVMRTPGWREVYESADESGLSGTGGYLDEEDGDEDGEGPQNEERVKAQTLPDLREGDVTGPAGISLTEGKTKPPAPFNEAALLSAMENPVRYMESGDRAMAKTLGETGGLGTVATRADIIEKLFSGFMLEKKGKDICLTSKAKQLLRLVPEDLRKPELTAQWEMRLSKIAEGEMKRDAFMEDIRTYTKDIVEEIKGGEGTFRHDNLTNTKCPRCGKRMLSVKGKNSQMLVCQDRECGYRETISRTSNARCPKCHKKMELRGKGENQMFSCVCGYKEKLSNFKERRQREGAGVTKRDVARYLNQQKKEEKMVNNPFADALKKMQEQDV
(326) DNA topoisomerase [Clostridium novyi NT]
3
MEKSLFITEKPSVAMEFVKLLNIKETKKDGFIESDNAIFTWCVGHMVTMSYPEAYDENLKIWSLKTIPFLPKEFKYELIPSVLKQFNVVKSLMLREDVKTIYVCTDSGREGEYIYRLVDMMVGVEGKDKKRVWIDSQTEEEIKRGIKEAKPLSEYDSLSDSAYLRAKEDYLLGINFSRLLTLIYGKTVSNIIGEDRVVIAVGRVMSCVLGMIVERELQIRNFEKTPFYKINGSIEIEENLGYECEFKAIEKSKYFESPKLYNDGGFKEKKDAEKLIEEIRIESKDNTAIIEKISKKKETKNPPLLFNLAELQNECSKNFKISPDETLNIIQELYEKKMLTYPRTDARVLSTAIAKEINKTISKLLRFKENEKVNNACKNILEKKLYVGLEKTKYVDDKKITDHYAIIPTGEGLESYRSLKPFQRNIYDLVVRRFLAIFYPPAIYSKITVETKIGEEYFFTTEKVCVTRGYLDILEEAQKDEKEKNLDFLNKLKKGTIVKIDELTIKEGKTSPPKRYTSGSIIIAMENAGKLIEDDELREQIKGSGIGTSATRAEILKKLERIEYIKVNNKTQIITSTTKGEVIYRVIRSSMPSLLNPKLTASWEKGLSMVVDREITPEVFMNKLENYINKNISNVVDNNRVINTNYLISGLEENNKKKIDEEKIDDVLGVCPICKKGTIVKNNKGYGCNNWKEGCKFFVAEICGVKIPVGEIKNLIKYGKTNIINGFKSKKGNEFRARLILKDNKVQLSFD
(613) DNA topoisomerase 3 [Clostridium novyi NT]
2
MGKILILAEKPSVGRDIARVLNCKKGGNGFLEGDKYIVTWALGHLVTLADPEAYDNKYKSWNIEDLPMIPKHLKLVVIKKSGKQFNTVKAQMNRKDVGEIVIATDAGREGELVARWIIEKAHIKKPIKRLWISSVTDKAIKDGFKNLKDGREYNNLYKSAIARAEADWLVGINATRALTCKYNAQLSCGRVQTPTIAMIAQREEEIKNFKPKTYYGIEAKSDKLKLVWQDSRSNDIKTFNKDKCENIIKNIKNKDAKVVEVNKVKKKKFSPQLYDLTELQRDANKIFNFSAKETLSIMQRLYENHKVLTYPRTDSRYLTEDVVDTIKDRLKACGVGVYGKYANKLLKGTIKGNKSFVDNTKVSDHHAIIPTEQKFALASLSDNERKIYDLVVKRFFAVLYPPFEYEKTTIKAKIGEENFIAKGKVVLANGWKEVYSNDFEDDMEDELKEQILPSINKGDSIKINSISKTTGETKPPKPFNEATLLSAMENPVKYMSGESKELKKTIGETGGIGTVATRADIIEKLFNTFLIEKRGKDIFITSKGKQLLDLVPEELKSPALTAEWEQKLTAISKGKLNKDKFLSEIKDYSKDTVNEIKNSKEKFKHDNMTRVKCPECGKYMLEVNGKKGKILVCQDRECGYRKGISRISNARCPECHKKLELRGEGEGQIFVCKCGYREKLSAFKERKKKDSGKVSKREVNKYLRQQQKENDEPFNNPFAEAFKKLGLK
(122) DNA topoisomerase 1 [Clostridium novyi NT]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVTASMGHVRDLPKSQLGVDIENNYNPKYITIRGKGELLSSLRKQAKKSDKVFLATDPDREGEAISWHLAEALKIDENEECRIEFNEITKNAIKSAIKNPRRLNLNLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMICDRENEIKEFNPKEYWTIECELKNEKSKKSFTVKLVSKNNEKIEINNEEESNSIIKELKQNKYIVKSIKKSEKHKKPLPPFTTSTFQQDSYKKLNFSTKKSMSVAQQLYEGIDIKGKGTIGLITYMRTDSVRISDEAQKNARQFITENFGQNYVPESIRNFKGKKNIQDAHEAIRPTYIELAPDEIKDNLKPDQFKIYNLIWKRFMASQMADCIMDTMSININNGQYTLRVSGSNIKFDGFKKVYKYEEDEESLKFPVLEENEILQDKKVEGKQHFTQPPARFSEATLVKTLEENGIGRPSTYAPIVSTLLDRKYIEREKKTLTPTELGFIVNNIVSEYFKQIVDVEFTAEMESKLDNIEEGKEKWKDVVNEFYSPLIECINIAEKEIAKIKIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVKELDVPCPVCGGKILLRKSRKGRKFYGCSNYPECNFVSWSEPVKDKCPNCGSYMVKKQSKSKGNYIECSNKECKTKIQQENQNVEK
(518) DNA topoisomerase 1 [Clostridium clariflavum DSM 19732]
1
MADKLVIVESPAKAHTISKFLGKDYKIIASVGHVRDLPKSQMGVDIENNFEPKYITIRGKGDVISKLKKEAKNAKKIYLATDPDREGEAISWHLAYLLNIDSKEKCRVTFNEITKNAVKNAMKEPREINLDLVNAQQARRILDRIVGYKISPILWKKVKKGLSAGRVQSVATRLICDREEEIEKFVPEEYWTIDAVLQKKDEKGSFNAKFYGKDGKKMELKSEDDVKRILENIKGKPFIVQKIKKGEKKKSPAPPFITSTMQQEAARKLGFSTKKTMIVAQQLYEGIDIKGVGALGLVTYIRTDSTRISDEAQQDVIQFIKEKYGEKYLPTEKRVFKNKNASQDAHECIRPSQVNMDPDSIKDSLTKDQYKLYKLIWSRFVSSQMASAEYDTISTDITIGDYTFKANGQMLKFPGFTVLYQESKDEEGEEKENDIPDLIEGEELKQKKIEPKQHFTQPPPRYTEASLVKTLEEKGIGRPSTYAPIITTILARGYVVKDGKTLMPTELGKIVNDIMKTYFQDIVDVEFTAQLEKKLDDIEEGYKKWVDVMQSFYSPFAKVLEEAEEKIGNVEVPDEVTDEICEKCGRNMVIKMSRFGKFLACPGFPECRNARPILEEAGVKCPKCGGKVYIKKSKKGKKYLGCENNPTCSFMSWDMPSKESCPKCGNFLLKKYLGKKVQLKCSNEECDFIKDGERKKEE
(1087) DNA topoisomerase [Clostridium clariflavum DSM 19732]
7
MGKNLYITEKPSVAASFAAVLGVNISKSDRTRGYAESKDSVVTWCFGHLITLALPDAYNDAYKEWKVEHLPIIPEEYKYVVIDDEGIKKQFETVKSLMLREDIDYIYACTDSGREGEYIFRLVYEHSGTTKPAKRVWISSQTEEAIKEGIKNAKDISHYDSLAQAAYSRAKEDWLFGMNFSRIYTCLYGRHLSALLKESRSSVIAIGRVMTCVLGLVTDREKEIRNFVPKTHYGITANFISMDNKIEYKGKWVPEKSKIIKFADDAQDEERYISKQEAEEVIEKLKGKEGKVKKVEIKSKNEQPPLLFNLAELQSEANKKFKLPVDKTLETAQSLYEKKLITYPRTDCRVLSTDVVGELPKVLNGLYMNPEYKGFVSRIKDFGELKITKSTKRYVDDSKVTDHYALIPTYVTADLNRLSENERKIYNLIVKRFLAIFYPPAVYNTVKVETEIDGEVFVTSSRTLKEAGWKEVYEVSKSKDEEDLTEVPIHLLSKNEGCETKNFELEEKETKPPPRYTAGSLIITMEKAGKFIEDEELREQIKTCGIGTSATRAGIIKKLKDIGYINIDSKTQVVTPTLKGEAIVELVRRTAKELLSPSLTASWEKGLAMIENKETTQEIFEKKLCDYINKTIQKVKKSNSDNSINLIRMFKDVI
(1618) DNA topoisomerase 3 [Clostridium acetobutylicum ATCC 824]
2
MGKILVLAEKPSVARDLAKVLKANINKKTHLEGNKYVVIWALGHLVSLADPESYGEKYKKWSMDTLPMLPKNMKLSVLKNTSKHFYDIKKVMERKDLDELVIATDAGREGELVARWIIEMAKWKKPIKRLWISSQTDRAVRDGFAHLRDGRDYENLYKSAKCRSEADWFVGLNVTRALTCKYNAQLSAGRVQTPTLYMIVSREEEIRKFKPKDYYTIEGKVKSFSMNWHDKSGDFKIFNKERAEKIEALVKGSKGKIVDVSESKKKKYSPALYDLTELQRDANRFFGFSAKETLSIMQRLYENHKLLTYPRTDSRYIPHDVVATLPDRLRAISIGKYSKFAAEILRSKINVHKGFVDDSKVTDHYAIIPTEERPALGALSNEEFKIYDLVVKRFLSIMLPPFEYIQTTVKAEVAGEIFIAKGKVVKSKGWKEVYDKTEDFEEKSELKDQMLPEMNKGEDITFSTVSIKKGQTKPPSRFTEATLLSAMENPQRYVSMDKISAKTLGETGGLGTVATRADIIEKLYKTFYIEKKGNEIVPTSKGKQLVNLVPSDLKSPLLTAKWEGQLDAISKGKLNGVSFVNEIKGYASKLVDDVKGSKDTFKYDNLTGTKCPECGKYMLQVNGKKGRMLVCQDRECGHRENLAMFTNVRCPECHKKLELRGEGEGRIYVCPNCSFREKYSSFQKRFKGNNNKVNKREVSNYMKKMKKEAEAPINNAFADLMSMFKDKN
(1526) DNA topoisomerase 1 [Clostridium acetobutylicum ATCC 824]
1
MGQKLVIVESPAKAKTIGKYLGKNYIVEASMGHVRDLPKSTLGVDIDDNYNPKYITIRGKGELLDKLKKAAKKCDKIYLATDPDREGEAISWHLSKVLKIDESEKCRIEFNEITKNAIKTAIKCPRKININLVDAQQARRVLDRLVGYKISPILWRKVKWGLSAGRVQSVALKMVCSREKLINDFKPEEYWSIDAQVYKQSKKDKFTIRLTSFKGKKIKINNEEENEQIINSIKKDEFKVENVKEGTKNKNTLPPFTTSTLQQDANKKLNFSTKKTMSVAQQLYEGIDVKGHGTIGLITYMRTDSVRVSKEAQEAANDYILNEYGKEYLPPSPKLYKSKKNIQDAHEAIRPTYIELTPGMVKSSLKDDQYKLYNLIWSRFMASQMANCILNTLSIEIKNGEYTFRASGSNVKFEGFMRVYKYNIEEDEHNEKIPLLQKGDLLHTDKIDGKQHFTQPPARFTEASLVKTLEENGIGRPSTYAPIISTLIDRKYVKKEKKAIFPTELGNIVDNILSDYFKQIIDIEFTADMENKLDNVEEGKENWKEIVDEYFKPLKEAIDIAEKEVAKITIEDEVTDIKCDKCGRNMVIKHGRFGDFLACPGYPDCKNTKPIVEKLKVKCPKCGGDVIVRRSKKGRKFFGCSNYPDCDFVSWFEPTEENCPNCGSFMVKKFSKAKGYYLQCSNQECKYEKSNPDPDKK
(1386) DNA topoisomerase [Clostridium acetobutylicum ATCC 824]
7
MRKILVISEKPSVGRDIANVLGCKTRGEGCLIGAKYIVTWAVGHLVTLWEPEEYNAIYKKWRFDTLPIIPEVMKIKPIDGTKKQFNIIKKLMNDNSVESLICATDAGREGELIFRYTYEAAECKKPFSRLWISSMTDEAIKEGFSTIKPGTEYDNLYHSAKCRSEADWLVGMNASRAYTLKYNVLLSVGRVQTPTLAIIVKRQKEIDNFEPKDYWEVVSKYEGFNGTWFDKETKESKIMDKKKADDLGAKILGQTGKVISIENKKKKQVPPLLYDLTELQRDCNKKFGFSAQKTLDIVQSLYEKRKMVTYPRTDSRYLSHDMVNKIKKTIGRLNINPYDKYVGEILKLSKLPMGKRIIDDSKVTDHHAIIPTDVKPNLSTLTKDELKVYDAIVRRFLCVFYPNYEYTITKIVTEVVEENFLTQGKTILKLGWMEFYKHDKKEKDDENSEPDELPKLKKNESVQVKDSEIKAKKTKAPSSYTEASLLSAMENAGRFVEDEQLKEQLKDGGLGTPATRASIIERLIQVGYIQRKGKSLHPTDKGMKLIEIVPYELRSPETTGKWEKGLSSISKGKMASERFMQSIKRYVQYIIQESVKVNRSVVFQNNDSKFPQKNKQLPEAIGECPFCKRGKVYENSKAFYCSEWKGGCKFTTWKDSLKNYGIQVDKDLEKKLLKERVLYNVFGIEPKSGEKTVYTLKMNNYGAVIAKTQ
Family distribution
Taxonomy tree
Clostridiaceae