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Taxon : Thermoanaerobacterales
Informations
Name
Thermoanaerobacterales
Rank
order
# topoisomerases
38
Lineage and sub-taxa
Lineage
Bacteria
>
Firmicutes
>
Clostridia
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Thermoanaerobacterales
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(276) Reverse gyrase [Caldicellulosiruptor saccharolyticus DSM 8903]
6
MATGAKYYHSCINCGGINSDTRNQKGLPCEKCLPFENNMNILESLKEHNSLKDYAYFWNFQNEYKEFEKFFVSKVGKPMTGYQRLWARRLLLSKSFTLIAPTGLGKTTFGLVATLWMAKNGKKVALIFPTVSLVEQTHQRLLEFANKEPKENVKILSYKSSMKRTEKDEFEKNFENGEFDILIVSSQFISKRKDDLAKKVFSLVFVDDVDAILKSSKNIDTLLQMIGIDQKTIDKTFENLKKGVKYPEQKQNGTSSTPSKGILIVSSATAKPQGLKPLLFRELLGFEIGRFTFSVRNITNIRIAGKSKVKLLETIKILNDGILLFVENEEEGKDVTNFLENEGISVGKTWEDFEKSFEEFKDGKLKILCGIYSYYGKLVRGIDLPLRIKYSIFWGTPSFRFSTDIEKAPRFVLERVFSDYLEEHPKLKSFFKNIDKYQVERLREVVKKYIPQDRWTDFIKKSFSNLKISDEGQIFFPDVFTYIQGSGRTSRMLGSSLTKGVSILFEDDDLLFESLRSRLMFLLDEEWKTEDEVCFEDLIKEVEMSRNEALIDERSSDLKSRLMIVESPTKAETISRFLEKASTRRYGRLSVYESVTPDGILLITASKGHVYDLDTKTGVHGVEISNGNFIPYYNSIKRCTSCGTQFTDEYSSCPKCGSDKIDDKKEILKVLREIAAEVDEILVATDPDVEGEKISWDISQYLKPVNPNLRRIEMHEITKFGFESAIKNQRDFNANLVKSQIVRRIEDRWVGFELSSKLQKNFQSYNLSAGRVQSTILGWIIEREKEYAKSQKEFTFVRFENGFGFEAEGKIDGDKVLVDVVEENEKELETILPFNTPTLLSYASQKLNLSVQEIMEILQFLFEHGFITYHRTDSNRISLTGQNMARLYLEKIGKKDLFVGRSFGSEGAHEAIRPVKPISPLELKELSSERLAQGLTANHIKVYELIFNRFFTSQMKNPLVRYQKLIFRFDKQEIEKEMPIEVIEEGWLLFSPIQIFSKFESGEYQIIEKKNYKKHTTPLFTQAMLIDEMKQKNIGRPSTYAKMVEILFKRGYVFEDQYRRIRSTALGRKVYSYLAQHYQDYINEETTRDLERLMEVVEIGEKDYQSVLSSLYEELTKIMQR
(1148) DNA topoisomerase 1 [Caldicellulosiruptor saccharolyticus DSM 8903]
1
MKKLVIVESPAKARTIAKFLGKEFKVEASMGHIRDLPKSDLGVDVENNFAPKYINIRGKADVINRLKKSAQEAEKVYLATDPDREGEAISWHLAIILGLDQNDKVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIEKFKPEEYWTLEAVFKKDNQEFKAKFYGSKKGKLELKNQEQVDKIINQIKDKNFKVTKLKISEKKKNPPPPFITSTLQQEASRKLRFTPAKTMMIAQMLYEGVEIKGEGSVGLITYMRTDSTRVAEEAQEAARRIILQRFGKEYVPEKPRVYKTKKDAQDAHEAIRPTYIEKDPESIKDSLTPDQYRLYKLIYDRFLASQMESSIYDSLSAELEVEGYVFKLTGSKLKFAGFMEVYVEGKDTDEEEEENQLPEIFEGEMLKPIKLEKKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKVVTNILKEYFKDIIDIEFTAELEENLDRIEEGKADWVEIVRKFYLPLEKELETARNTMQQIKVDDEETDVVCENCGRKMVIKKGRYGRFLACPGYPECKNTKPYFDYLDVLCPKCGKKLIEKKSKKGKKYFTCESYPECNFIVWERPAKNCPKCNQLMFEKGKKRSKKLVCSNESCGYEEKIVEKGE
(1638) DNA topoisomerase 1 [Thermoanaerobacter mathranii subsp. mathranii str. A3]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFTPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNFTKFEAKFYGTKEDKVELKTKEDVDKVLAALSEEYTVDKIKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYANPGANYASKKANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDIQEEEEKTVPVLQEGTKLLLKELKPTQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDNKNLKPTELGFIVTDALKEFFTKIVDVKFTAEMEEQLDKIEEGQAKWYEVVQEFYNDFYKTLKIAEEQMEEIDIKEEVEVTDIKCEICGRPMVIKKGRYGKFLACSGFPECKNTKPLYEKIGVKCPKCGGEIVRKKSKKGRMYYACENAPNCDFILWDKPVEEKCPVCGSLLIEKNTKNIHILKCSNAECDYQKEVK
(1780) DNA topoisomerase 1 [Mahella australiensis 50-1 BON]
1
MANNLVIVESPAKAKTISKFLGRGYKVEASMGHVRDLPKSQMGIDIEHGFEPKYITIRGKGEIVDKLKKQAKAVDRVLLATDPDREGEAISWHLAQLLDIDMDKACRIEFHEITKNAIKDALKHVRPIDKNLVDAQQARRVLDRLVGYSISPLLWRKIRKGLSAGRVQSVALRLICDRQQEIDNFVPQEYWTLTALLASDKGETLEARFYGKDTKKQELKDKESVDAIIKDINGSDFIVEKIERGQRKRKASAPFVTSTLQQEAARKLRFTAKKTMAVAQQLYEGVELGKEGMVGLITYMRTDSVRVSQEARREARNYIAERFGDNYVPDKPNEFRNRKGTQDAHEAIRPTYINYTPDYVKSFLSRDQYRLYELIYNRFIASQMSDAVYDTISVTIKAGDYVFKASGSTLIFPGHLALYMEGQDDDNDDKEQKLPPLEEGQRLILKKWMPEQHFTQPPPLYTEASLVKMLEEKGIGRPSTYAPIISTIVERGYVVREKRTLKPTELGILVNDMLKEHFPDIVDVSFTAQMEQMLDDVEEGQKDWHNIISEFYFPFKSVLDKADQSIEKVDVPDEQSDVICEKCGRRMVIKQGRYGKFLACPGFPECRNTKPLLEELKVTCPKCGGHIQIKRSKRGRKFYGCENYPKCDFVSWDEPTGELCPECGYPVVIKYSKNGRKYTRCSNKDCKYTGQKLAGEAK
(922) DNA topoisomerase 3 [Tepidanaerobacter acetatoxydans Re1]
2
MSKTLVLAEKPSVARDIARVMNCGKNGNGYLEGQKYIITWALGHLVTLAEPEAYGNRYKSWRMEDLPILPKDLKLEIIKQSRRQFNIVKEQMNRNDVNSIVIATDAGREGELVARWIIKMANVKKPIKRLWISSVTDKAIRDGFNNLKDGKQYENLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAMIAKREEEIQNFKPRDFYGITATVGNLKLVWQDSQTRDIRTFDKGKIDRILASLRGKNAEVIDVTKTLKKSFAPQLYDLTQLQRDANKIFGFSAKETLSIMQRLYENHKLLTYPRTDSRFITTDIVATLEDRVKACGVGPYRTAAFKIKRPIKGNKSFVDNGKVTDHHAIIPTEQPAFLDSLSENERKIYDLVVKRFLAAMYPPFEYEQTTIKAKIGTEIFIAKGKTVIALGWKEVYEGFDDESSEDENLNDGIFEQILPTMSKGDILKITSIFQTQGRTRPPAPLNEGTLLAAMENPVKYMPKDNKDLIKVIGETGGIGTVATRADIIEKLFNSFLIEKRGKDIFITSKGRQLLDLVPEELKSPALTAQWEQKLSAIAQGALKKDTFVNDMKNYAKRAVQDIKNSEDKFRHDNLTRSKCPQCGKYMLEVNGKKGKMLICQDRECGYREKLSKVTNARCPNCHKRLELHGEGEGQIFICNCGYREKLSAFNERKASEGNNKVSKRDVAKYLQKQKKDEDKPINTELADALAKLKL
(1026) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(921) DNA topoisomerase 3 [Tepidanaerobacter acetatoxydans Re1]
2
MSKTLVLAEKPSVARDIARVMNCGKNGNGYLEGQKYIITWALGHLVTLAEPEAYGNRYKSWRMEDLPILPKDLKLEIIKQSRRQFNIVKEQMNRNDVNSIVIATDAGREGELVARWIIKMANVKKPIKRLWISSVTDKAIRDGFNNLKDGKQYENLYASAVARAEADWLVGINATRALTCKHNAQLSCGRVQTPTLAMIAKREEEIQNFKPRDFYGITATVGNLKLVWQDSQTRDIRTFDKGKIDRILASLRGKNAEVIDVTKTLKKSFAPQLYDLTQLQRDANKIFGFSAKETLSIMQRLYENHKLLTYPRTDSRFITTDIVATLEDRVKACGVGPYRTAAFKIKRPIKGNKSFVDNGKVTDHHAIIPTEQPAFLDSLSENERKIYDLVVKRFLAAMYPPFEYEQTTIKAKIGTEIFIAKGKTVIALGWKEVYEGFDDESSEDENLNDGIFEQILPTMSKGDILKITSIFQTQGRTRPPAPLNEGTLLAAMENPVKYMPKDNKDLIKVIGETGGIGTVATRADIIEKLFNSFLIEKRGKDIFITSKGRQLLDLVPEELKSPALTAQWEQKLSAIAQGALKKDTFVNDMKNYAKRAVQDIKNSEDKFRHDNLTRSKCPQCGKYMLEVNGKKGKMLICQDRECGYREKLSKVTNARCPNCHKRLELHGEGEGQIFICNCGYREKLSAFNERKASEGNNKVSKRDVAKYLQKQKKDEDKPINTELADALAKLKL
(1025) DNA topoisomerase 1 [Tepidanaerobacter acetatoxydans Re1]
1
MAKSLIIVESPAKAKTLSKYLGKNYKIEASMGHIKDLPKSQLGIDIESGFAPKYITIRGKGPLLNNLKKEAAKADKILLATDPDREGEAISWHLANALDISESEPCRIEFYEITKNAVLESLKNPRTINTDLVEAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSVAVRIICDREKEIKEFIPDEYWTIDADLKGDKDKIRARLHSKNNKKIKIENKEQADMILEEIKNKTFEVAEIKTSERKKMPPLTFTTSSMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGAVGLITYMRTDSTRISEQAKKEAAEYIGYNYGKEYLGSGYTARKNNKKNVQDAHEGIRPTSVIRTPEKVKDSLTKDQYKLYKLIWDRFVSSQMAAAVYDTVSVSIKAGEYIFKVSGSTVKFPGFMLLYTEGSDEDSEKDDSKIPQLKEGQVLKLLKLLPEQHFTQPPPRYTEAMLVKVLEEKGIGRPSTYAPTIDVIQKRGYVEKEKGRFKPTELGEIVVQILQEFFSDIVDIDFTAEMEEKLDKIESGHQKRQELLESFYTSFEKKLKIAEQELKKVKIEDEISDEKCEFCGRNMVIKNGRYGKFLACPGFPECKNTKPIITEIGVKCPQCGGNLIVRKSKRGRTFYGCSNYPNCKFVSWNKPSDKPCPKCGALMVIKKTKNGEHKVCTNKECGYKSK
(478) DNA topoisomerase 1 [Ammonifex degensii KC4]
1
MKHLIIVESPAKARTLSKFLGSQFLVKASMGHVRDLPKSELGVDLENGFTPKYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWHLCHLLGIPPETPCRVEFHEITKNAVLNSLKSPRPIDLNRVNAQQARRVLDRLVGYGLSPLLWRKVKRGLSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLARLARFKGKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQEANRRLGMRLERTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIKEHYGAEFVGDVPPKERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLIWERFLAAHMAPAKYFLTRAEIEVGDYTFYATGRQLLFPGFLRLWRPEEEEEEGKLPPLREGEVLTFQEFVPQQHFTTPPPRYTEGTLVKALEEKGVGRPSTYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLKEHFPGIVDVGFTAAMEEKLDLVEEGQADWVDILREFYQSFSQDLVRADAAIEKVSLPDTFTDISCPRCGCPMVKKTGRYGEFLACSGYPECQMRMPVGTGVKCPRCGGELVKRRSKKGRYFYGCNRYPECNFVVWSEPVPEPCPECGSLMVRRGRGKKKRVICTNESCGYQRLEE
(982) Reverse gyrase [Ammonifex degensii KC4]
6
MELFLLAHGCPNCSGSVTDERLAAGLPCPQCLPQAGNNLSLAAVCCALRKENKIRELSPFCRAEEGLKEFELFFRQVTGLNLSPLQRLWAKRFFLEEPFAIIAPPGVGKTTFGLTVSLYNPQKSLILVPTRLLVWQVAEKLSHFAEKAGSKKKILSMTGKAKEKKELMQSEYDILVATTQFFYRHWSEIASHPITLVFIDDVDALLKSSRQVDSLFYFLGYSPEEVERALRSPEGEPREAGKRPQRLLILSSATLKPRTNRVRLFQRLMGFSVQRAVSTQRRVVDCYEEVPDFARALARAAELVRQLGPGGLVLVSPEEGREGVKEATAYLQAQGIEAESYLELTPEELVSRLAEGSLEVAVGLAHPTNPLVRGLDLPHVLKYVIFVGAPSHFFPLDLSPAPGALHGLGLALFPLFTPEEQRQVLRELRYLRPYLNLPADAVSRYPALEKRVQAFASFLKEKLKDPSFWEKIRAAEDLNLREEEGKLYLVLGDATTYLQASGRVSRLTAAGLTRGLAITLCTERRVLLSLKKRLRALTPAEIEFIPLQEVDLAGVMRGIEEDRRRIKAGELADKEGPRTALVVVESPHKARTIASFWGKPGIRRVKGVLAYEIPADERHLIITASLGHVFNLSRQQGFFGVLTFNHHFLPVFDTIKIYRETGEELVDPEEVARYPEGTVWDKQEILRGLQHLAFEVDEVYIASDPDAEGEKIAYDLYLSLRPFNPHIYRLEFHEVTPSAFRRALENPGQVNLYRVQAQLTRRVLDRWVGFCLSRRLWQKFGNRHLSAGRVQTPVLGWVVARAEEGRQRKARLTFSLGEATFTLEVPDRELGQKIFGELEKLSWEILEISEEERSPLPPFTTDTILTEAAHRLRLSAPVTMKLLQELFELGFITYHRTDSTRVSETGRFLVAKPFILQHYGEELFHPRSWGEGGAHEAIRPTRPMTEAELRWMVGAGLVDLSQERALELYGLIFRRFMASQMAPARVRKAKVRFRVPSYAWETEVVVEQIAPGFALLWPNFSVTELRPEARLTGKEYRELPLAEPYTEGTLVQEMKRQGIGRPSTYAEIVATLLNRGYLVVRGGRLYPTRLGFKVYRYLKENFPEYADTALTREIEAAMDLIAEGKEDYQEVLQKLYKVREILA
(287) DNA topoisomerase 1 [Thermoanaerobacter sp. X514]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNSGKFEAKFYGTREDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYTNPEANYASKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFLASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVQEFYEDFYNTLKIAEEQMEEIDVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPNCDFILWDKPVDEKCPVCGSLLVEKNTKNGHILKCSNPECDYQKEVK
(693) DNA topoisomerase [Moorella thermoacetica ATCC 39073]
7
MVNACDAGREGELIFRRIYAWCKGQKPVKRLWLSEATPAAIKEAFRHLRVGEELDNLAAAAEARAQADWLVGINTTRAFTCRHNRLLSVGRVQTPTLALVVAREREIRAFKPEPYFEVWATFRKSTGETYRGKWFREKQDRLQDKKKAGDLAKQISACGIVEKIEQKEVREQPPQLFNLNDLQKEANKKYGLTAQKTLDAAQALYEKHKLLTYPRTDSRHLTTALVRDTLAGRLEALTGIPAYAALVPENLPQLGKRYVDDSKVSDHHALIPTAVNPDLSKLSPVEQKVYDLVARRFLAIFYPDARYAVTRVVTTAGGESFLSQGRVELERGWKAVYGRQEEDGAESKDEESQTLPQLVEGEEVAVQGVEVKAKQTRPPQRYTEATLLAAMENAGRLVEDKEMADTLKTAGGIGTPATRAAIIERLIQVGYLRREKKNLLPTAKGETLIGLVPEEVKSVELTARWEEGLKEIEEGQRDCKEWLEGIKNFTTEVVRMAREQEAAPGADPDREVLGQCPICGREVMEYPKSYSCSGYKEGCRFAIWKEIAGKKVTASQAKELLQKGKTGVIKGFKSKTGKKFDAALTLGEGGKVNFEFAEGNRETLGKCPLCGKDVTESQKGYGCSGWKEGCKFVIWKEIAGKKITAGQAKELLQKGRTGVIKGFKSRAGKEFEAILVLKEDGKLEFEFEG
(1288) DNA topoisomerase 1 [Moorella thermoacetica ATCC 39073]
1
MLAKTLVIVESPAKAKTIGKFLGKNYTIKPSMGHVRDLPKSQFGVDVENNFEPRYITIRGKGEIVKELRAAAQKAQRVLLAPDPDREGEAIAWHLQHLLGLPDEAIRIEFNEITRNAIQEAVKKPRKIDQDRVDAQQARRILDRVVGYRLSPLLWRKVRKGLSAGRVQSVAVRLIVDREQEIEAFQPEEYWSLTAWLLPENEGEAFPARLVKYAGEDLNVKNEGEMESILHSLEGTTYVVAEVKQRERRKNPAAPFTTSTLQQEAYRKLNFTSRRTMQVAQQLYEGIDLGGGQGPVGLITYIRTDSTRVASVAQLEARDFLMERFGSEYVPEGLRQYKGRKDIQDAHEAIRPTSVWREPASLKNILTRDQFRLYNLIWERFVASQMQAAVMDTVTVDITAGPCLFRATGSVVKFPGFLKVYQEGRDGEDKDQEQRLPPLATGQTLKLQSLEPKQHFTQPPPRYTEATLVKTMEELGIGRPSTYAPTIETILQRGYVTREQKQFVPTELGRVVVALLKEHFPKIIDVEFTAHMEEQLDAIEAGKISWRQVLAEFYGPFEEVLEKAEAEIGTVEVPEEVSEEKCELCGRNLVVKMGRYGKFLACPGFPECRFTKPLLETIGVNCPECGGQIVARRTKRGRKFYGCQNYPRCTYVSWDKPTNQTCPRCGKRLVEKASRQGSRLVCPQKECGYVEEVRQAK
(129) DNA topoisomerase 1 [Caldicellulosiruptor lactoaceticus 6A]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEVLKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVSCPKCSKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGGLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(810) Reverse gyrase [Caldicellulosiruptor lactoaceticus 6A]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEQCLSQEQISKNIFESLKKKGTLKDYQIYWNFQQNFDTFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEAFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFENLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILSELFNDLKNLIEN
(132) DNA topoisomerase 1 [Thermosediminibacter oceani DSM 16646]
1
MAKSLIIVESPAKAKTISRFLGKEYRVAASMGHVRDLPKSKLGIDIEKGFVPKYITIRGKGSIIENLRKEAAKAQKVLLATDPDREGEAISWHLAHLLDIPPETPCRVEFHEITKTAVSESLRHPRKINMNLVDAQQARRILDRLVGYKISPILWRKVKWGLSAGRVQSAAVRMICDREKEIAEFVPEEYWTIEAELADRPDGSSFKAKLHSRGNEKINLKNREQVEKIVADLQDQVFVVMEIKRGERRRNPAPPFTTSTMQQEAARKLGFTAKKTMMIAQQLYEGLDIKGEGTVGLVTYIRTDSTRISEQAQKEAKEYIKANYGSEYVAESMSVKKAKKNIQDAHEGIRPTSVFRHPDSIKDSLTLDQYKLYKLIWERFLASQMAPAVYDTVSIDIKAGSYIFKASGSTLKFTGFMAVYIEGADEETEKDEGTLPILEQGQKLTLLKIMPEQHFTQPPPRFTEAMLVKALEEKGIGRPSTYAPIIDTIQKRGYVKKEKGRFKPTELGQLVTEILKEYFSDIVDLDFTAEMENQLDKIEAGEENWQKIIESFYRPFEEKLKIAEEKIEEVKIEDEVTEEKCELCGRNMVIKHGRYGKFMACSGFPECKNTKPLLEETGVKCPVCEGVIVVRKSKKGRKFYGCSNYPNCEFVTWDPPSETPCPRCGGLMVVKSTKSGKITACTNTECGYKDQVEG
(1084) DNA topoisomerase 1 [Thermoanaerobacterium xylanolyticum LX-11]
1
MEKSLVIVESPSKAKTIHKYLGKNYKVEASMGHIRDLPKSQLGIDIEKNFEPKYITIRGKGPIIEKLKKEAKNASKIYLATDPDREGEAISWHLASLLNIDINEKCRIEFHEITKNAIQNAIKNPREINMNLVDAQQARRILDRLVGYNISPLLWKKIKRGLSAGRVQSVATRLICDREKEIEDFKPEEYWSISAYLYKEKKTQSFEAKFYGTKDGKVELKNENDVNEIVKDLTDDYVVENVKIGTKKRNPSPPFITSTMQQEASKTLGFTAKKTMMIAQQLYEGVEIKGEGSLGLITYMRTDSTRVSDEAKKAAYEYILQKYGKEYANPNATYAKKGGNIQDAHEAIRPTYIDLDPEKIKDSLKPDQYKLYKLIWSRFLASQMSPALYDTMNVDIINKNYVFKASGSKIKFSGFMAVYTDDDENENEDKMLPMLNSGDFLKLKELKPEQHFTQPPARYTEATLIKELEEKGIGRPSTYAPIISTLLERGYVIKEKKNLKPTELGFIVTDVMKEFFPDIVDVKFTAQMEEQLDRIEEGIEKWCDVIDEFYNGFNASLKIAEEQMKDIEIKDEETDIKCEFCGRNMVIKYGRYGKFLACPGFPECKNTKPLYEEIGVTCPKCGGKIIIKKSKKGKVYYACENSSNCGTMFWDRPISETCPKCGALLVEKHSKGRKIIKCSNCDYVK
(1776) DNA topoisomerase 1 [Caldicellulosiruptor bescii DSM 6725]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINKLKKYAQEAEKVYLATDPDREGEAISWHLATILGLDTNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRILDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDVQEFKAKFYGDKKGKIELKNQDHVQKIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRVSEEAQQAARSLIVQKFGKEYLPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSVYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEALKPIKLESKQHFTQPPSRYTEATLIKALEENGIGRPSTYAPTIQTILERGYVAKEDRFLKPTELGRIVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVKKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPVKNCPKCGSLMFEKGKKGNKKLVCSNENCAYQEKTGEKGE
(1030) Reverse gyrase [Caldicellulosiruptor bescii DSM 6725]
6
MATGAKYYHSCINCSGINTDTRNEKGLPCEKCLKDDHLTENVFELLKGRGLLKDYQIYWNFHQNYKMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTVSLAQQSFERLEEFKTKLENANAVKILLFNSSMTKSRKEEFEKRFISCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAVLKSSKNIDTLLQMIGFSEDEIEKATERLRSKNRENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLDNSIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFSIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEILQTEKLRQLVSKYISKEDYSKIVNKIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKVSRKIQNDDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALRNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLDVPRIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGNEGAHEAIRPVKPISPEELKELAYEKYTQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFKINDIEIVKDIPVKVEEEGWLEFLPMQIYPLFENKDYSLTDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLLELYNDISVLLNN
(1340) DNA topoisomerase 1 [Caldicellulosiruptor kristjanssonii I77R1B]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQRIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEILKPIKLDSKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELEENLDKIEEGKLEWTEVVRKYYQPLEKELEIARNTMLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPECGNLMFEKGRKGNKKLVCSNENCAYEEKIGEKGE
(946) Reverse gyrase [Caldicellulosiruptor kristjanssonii I77R1B]
6
MATGAKYYHSCINCGGINTDIRNENGLPCEQCLSQEQINDIYESLKKMGTLKDYRLYWNFQQNFDMFEKFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANAVKILLFNSSMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFLIDMDKAPRFVLERVFVEYLDNHPKLKGYFKSVDSLQTEKLRQLVSKYISKEDYSKIVNEIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWVEENGVDFKNLMEEVEESRKIQNHDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELSLEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEIECERVKAQIVEQKIEEISAPAPFSTSSLLSLASQKLNLGVPQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKVEEEGWLDFLPMQIYPLFENKDYGITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLQELYNDISALVND
(1306) DNA topoisomerase 1 [Caldicellulosiruptor obsidiansis OB47]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAEAAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATKLVVEKEEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQIQEIEEKIKNKEFKVVKLKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARKLIAQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMNPESIKDSLTPEQYKLYKLIYDRFLASQMESSIYDVLSAELEVEGYVFRLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEISEGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKIEWTEVVRKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKKVIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPKCGSLMFEKGRKGNKKLVCSNENCLYEEKMGEKGE
(1675) Reverse gyrase [Caldicellulosiruptor obsidiansis OB47]
6
MATGAKYYHSCINCGGINTDTRNENGLPCEQCLSQKQINDIYKSLKKMGTLKDYQLYWNFQQNLNAFKMFFEHIFQKPLTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTISLAQQSFERLEEFKAKLENANTVKILLFNSLMTKSRKEEFEKRFLSCDFDILIITTQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRTKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLAENGIKIGTTWSNFDEEFELFKEEKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPRFRFSVDMDKAPRFVLERVFVEYLEDHPKLKEYFKNVEILQTEKLRQLVLKYISAESYNKIVQEIFSHLKITDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMEENEVDFESLMEEVKESRKIQNNDFYQIDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIEDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNINLVKSQIVRRIEDRWVGFELSSKLQENFQSYNLSAGRVQSTILGWIVEREKEYAKSERTFTMLKLENGYNLEIEGEEECKRVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKEFFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIRVYQLIFNRFMSSQMKNPKVLFQKVCFKIADKEIVKDIPVKIEEEGWLHFLSMQIYPLFENKDYSVTDRRSYKKHTIQLYTQSSLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILQELYNDISELLNK
(969) DNA topoisomerase [Coprothermobacter proteolyticus DSM 5265]
7
MSILIVTEKPSVARQIAAALGKPKKEGNHLVVGEYVIAHAMGHLLQFAYPEHYGERYKKWRLEDLPIMPKEDEWQLVPISKTAVKQLEEIKTLWAKADMVISATDAGREGELIFRLIQQYVGIEKPIKRLWLQSLTKETIREQIKQLLDLSELDNLYASALARAKADWLVGINASRAFTVVSKKEVFSIGRVQTPTLAILVDREKEIQSFVPRIYYKVKVRFEVEGKSFWAESVKEYDQEEAEKLAEELIGKTLIVTEQTEEQAKINPPLLPDLGDLQKFTSRSFKWSAQKTLKILQKLYENALITYPRTDSRYLPTDMKKQVIGTANQLEPLFAKGNWEYVKKLNNRGRIFNNARVTDHFAIIPTGKIKELKGDDEKMFNYVVDRFLAAFYPPALETHQKTVFSYGNHLFEYAAVRVDDPSWYTILGGKESQELLPKIAEVMVLETSAEKRQTRPAPRFTDGMLIAAMETAGKLVESEELAEILKEKGIGTPATRAEIIERLIEMGYVQRNGPQLIPTSKGIMLIDALREVKLQSLTEPELTGEWERRLGLIEKGKETPESFMWSIEEYVKDVVQTLSKEESSKTLKSKQNMPIAKCPFCDGYILEGQKSYYCSNWKEGCKFRVWKNMNGGVITADDVRRLVAEGRTRLKRFRSKAGKAYRAFVVLKDGEVVIEFPTRKKKDGE
(136) DNA topoisomerase 1 [Thermoanaerobacter brockii subsp. finnii Ako-1]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKGYANPEANYVSKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVEEFYKDFYKTLKIAEEQMEEIEVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPDCDFILWDKPVEEKCPVCGSMLIEKNTKNVHILKCSNPGCDYQKEVK
(665) DNA topoisomerase 1 [Thermoanaerobacter wiegelii Rt8.B1]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYSNPEANYASKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFLASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQERTKLFLEELKPMQHFTQPPPRYTEASLIKELEERGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVQEFYKDFYKTLKIAEEQMEEIDVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRNYYACENAPDCDFILWDKPVNEKCPVCGSLLVEKNTKNGHILKCSNPGCDYQKEVK
(1161) DNA topoisomerase 1 [Thermoanaerobacter italicus Ab9]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFTPKYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITAILSDEKNFTKFEAKFYGTKEDKVELKTKEDVDKVLAALSEEYTVDKIKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKEYANPRANYASKKANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDIQEEEEKTVPVLQEGTKLLLEELKPIQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDNKNLKPTELGFIVTDALKEFFTKIVDVKFTAEMEEQLDKIEEGQAKWYEVVQEFYNDFYKTLKIAEEQMEEIDIKEEVEVTDIKCELCGRPMVVKKGRYGKFLACSGFPECKNTKPLYEKIGVKCPKCGGEVVRKKSKKGRMYYACENAPNCDFILWDKPVEEKCPVCGSMLIEKNTKNIHILKCSNPECDYHKEVK
(314) DNA topoisomerase 1 [Caldicellulosiruptor kronotskyensis 2002]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAQEAEKVYLATDPDREGEAISWHLATILGLDTNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDVQEFKAKFYGDKKGKIELKNQDQVQKIEEKIKNKEFKVVKIKVSEKKKSPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRVSEEAQQAARSLIVQKFGKEYIPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTLDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFRLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGETLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVAKEDRFLKPTELGRIVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVKKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRIIEKKSKKGKRYYTCEGYPDCDLILWEKPVKNCPKCGSLMFEKGKKGNKKLVCSNENCAYQEKTGEKGE
(1218) Reverse gyrase [Caldicellulosiruptor kronotskyensis 2002]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEKCLKDDHLTENVFELLKGCGLLKDYQIYWNFHQNYKMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFLALNGKKSALVFPTVSLAQQSFERLNQFKSKIQNTDVIRILLFNSSMKKSEKEEFEQRFLSQDFEILIVTSQFVSKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNRENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSKEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENSIKIGATWNDFEKEFELFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFKFSIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEILQTEKLRQLVSKYISKEDYSKIVNKIFSHLKLTDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFDSLKSRLMFLLDEEWMEENEVDFESLMEEVKESRKIQNDDFYQNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITQDGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKDILKTLRELALEVDEVLIATDPDVEGEKISWDISQYLKPANSNIKRIEMHEITRYGLDSALKSPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFKNYNLSAGRVQSTILGWIVEREKEYAKSEKTFTLLKLENGYNLEIEGEEECKKVEAEVVEQKIEEIPAPAPFTTSSLLSLASQKLNLGVQQLMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRSFGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKILVQKVHFRINDIEIVKDIPVKVEEEGWLEFIPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLQELYNDISVLLNK
(480) Reverse gyrase [Caldicellulosiruptor owensensis OL]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEKCLEDDHLTENVFELLKGRGLLKDYQIYWNFHQSYKMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFSALHGKKSALVFPTISLAQQSFEKLNQFKSKIKNADAIRILLFNSSMTKSEKEEFEQRFLSQDFEILIVSSQFISKRKDVLSKMFFNLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLKNKNKENGQNTNLNTLKDKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKKKSREKLLEIINILKDGILLFVNTEEEGKEIVKFLAENGVKIGTTWSNFDEEFELFKEGKLNVICGVSSYYGKLIRGIDLPERIKYCIFWETPSFRFSVDMDKAPRFVLERVFVEYLEDHPKLKEYFKNVETLQTEKLRQLVLKYISAESYNKIVQEIFSHLKITDDGKLVIPDVPTYIQGSGRTSRMFGMRLTKGVSILFEEDDTIFESLKSRLMFLLDEEWMDESEANFESLMVEVEESRKSRNEGFNVNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEFHDGKFIPYYNSIKRCTKCYTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNTKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWVGFELSSKLQENFQSYNLSAGRVQSTILGWIVEREKEYAKSERTFTMLKLENGYNLEIEGEEECKRVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFLEKVGKKELFLPRNFGDEGAHEAIRPVKPISPEELKELVYEKYAQGVSQNHIKVYQLIFNRFLSSQMKNPKVLFQKVCFKIADKEIVKDIPVKIEEEGWLHFLSMQIYPLFENKDYSVTDRRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRATSLGKKVYSYLSLKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILSELFNDLKNLLEN
(244) DNA topoisomerase 1 [Caldicellulosiruptor owensensis OL]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFVPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDNQEFKAKFYGDKKGKIELKNQGQVQEIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAIAQMLYEGVEIKGEGSIGLITYMRTDSTRISEEAQQAARNLIMQKFGREYLPEKPRVYKTKKDAQDAHEAIRPTYLEMDPESIKDSLTPDQYKLYKLIYDRFLASQMESSIYDVLSAELEVEGYVFRLTGSKLKFAGFMEVYVEGKDTEDEEEESQLPEISEGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTDVVRKYYQPLEKELEIARNTMNKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYHCLEVLCPKCRKRIIERKSKKGKKYYTCEEYPACDLILWEKPVKNCPKCGSLMYEKGRKGNKKLVCSNENCLHEEKIGEKGE
(1212) DNA topoisomerase 1 [Thermoanaerobacterium thermosaccharolyticum DSM 571]
1
MEKSLVIVESPSKAKTIHKYLGKNYKVEASMGHIRDLPKSQLGIDIEKNFEPKYITIRGKGPIIEKLKKEAKNASKIYLATDPDREGEAISWHLANLLNIDVNDKCRIEFHEITKNAIQNAIKNPRKINMNLVDAQQARRILDRLVGYNISPLLWKKIKRGLSAGRVQSVATRLICDREKEIEEFKPEEYWSLSAFLYKEKKTQYFEAKFYGTKDGKIDLKNENDVNNIIKDLADDYIVDNVKTGTKKRNPSPPFITSTMQQEASKKLGFTAKKTMMIAQQLYEGVEIKGEGSLGLITYMRTDSTRISEEAKKAAYEYILQKYGKEYANPNTTYTKKGGNIQDAHEAIRPTYINLDPDQIKDSLKPDQYKLYKLIWSRFLASQMSQALYDTITMDIINKNYIFKASGSKLKFAGFMTVYIEEADTENIEEKTLPLLEKGDHLKLKVLKPEQHFTQPPARYTEATLIKELEEKGIGRPSTYAPIISTLLERGYVIKEKKNLKPTELGFIVTDVMKEFFPDIVDVKFTAEMEEQLDKIEEGIEKWCDVIDGFYNNFNDSLKVAEEQMKDIEIKDEVTDIKCEFCGRNMVIKYGRYGKFLACPGFPECKNTKPLYEETGIICPKCGGKIIVKKSKRGKTYYACENSSQCGTMFWDKPINETCPKCGNLLMEKYIKGNKVIKCSNCDYVK
(1834) DNA topoisomerase 1 [Carboxydothermus hydrogenoformans Z-2901]
1
MKKLVIVESPAKAKTIGKFLGKEYVVKASMGHIRDLPTYRFGVNIEKDFAPTYEIIRGKKELIKELKEEAAKAEKVYIASDPDREGEAIAWHVKEVLDLEDNGDLRIEFNEITKDAVLQAIANPRGIDYNRVYAQQARRILDRIVGYKLSPLLWRKIKKGLSAGRVQSVAVRLICEREEEIEKFVPEEYWSLTAHLEAEKKPFKAKLSKYQNRKIEIKNKDEVERIIAEVSQRDFKVVKITKKLTKKSAPEPFITSTLQQEASKRLNFSAKKTMQIAQALYEGLEIGEYGVTGLVTYIRTDSTRVAEEAKAKAAAYIKNTFGEEYVGTEKKTKAPKGKIQDAHEAIRPTDIEKDPEKIKQYLTPDQYKLYKLIWERFVASQMSDAQYDVTTVDIEAGDYLFRATGSILRFPGFTKIYQVEEEEGEKEEKEKLPALMEGQSLTLLKLEPKQHFTEPPPRYTEATLIKALEEKGIGRPSTYAPILETILKRGYVEKDKKQLKPTELGRIVVDLLKEHFPDIIDVEFTAEMEEKLDQIEEGEKNWIEVLRNFYEPFNETLRQSYEKIEKIILPLEETEEKCPNCGRNLVVRTSRFGKFLACPGYPECKFIKPFVQKTGATCPRCGGEIIVKKSKKGRVFYGCSNYPSCDFVSWDLPSSKKCPNCQSVMVEKRPKKKPPYLLCTNPDCKHTEPLEEVQ
(1634) Reverse gyrase [Thermoanaerobacter tengcongensis MB4]
6
MALATGAKYYHSCINCGGINTDTRNEKGLPCEVCLPFEDGDVLKGLKLNNSLKGYEKYWNLNQQYKEFEEFFFSKINKKPTGYQRFWAKRLLLSKSFTLVAPTGVGKTTFGLISALWIAKKGGKVALVFPTVSLVEQAAKRLIEFSKEDEDVNILFYTSSLKKKEREKFEKNFSEGNYDILVISSQFISKRKEQLSQKVFDLVFVDDVDAVLKSSKNIDTLLNMIGISQKAIDSTLDNLKKGNNSDKIQIEEKAPKGRLIVSSATAKPKGIKPLLFRELLGFEIGRFTTSARNITNVRIKEKSLEKLLYIINLLKDGILLFVPTEEEGKEIANYLEEHGVKLGKTWEDFEKSFEKFKEGSLQLLCGIYSYYGKLVRGIDLPLRIKFAVFWGTPSFKFSTKLENAPRFILERNFQDYLENNPKLKAYFKDLQRLSTEKLRKSVEKYISPETWEKLIQKNFPTTKFDKEKNLIVIPDVYTYIQASGRTSRIFGTSLTKGISILFEEDDSLFELLKARLLYLTEEEWTEEGEIEHLVKEAEETRKAISTDSSSKDMKSRMIIVESPTKAQTISKFLEKSSTRRYGSLMVHESITQEGILLLTASKGHLYDLETKTGLHGVEINDGRFIPYYNSIKRCSSCGAQFTDELPRCPYCNSDKIDDKKKILEALRDIAMEVDEVIIATDPDVEGEKIGWDISQYIKPVNKNVQRIEMHEITKFGFDKAIRNRRNCDVNLVKSQIVRRIEDRWVGFELSLRLQKNFQNSNLSAGRVQSTVLGWILEKEIEHSKSKKTVTQFTLDNGFKFEVDGKIDVDEVEVEIVEEKEQALSPLPPFNTPSLLTAASQQFKLPVQQIMEILQTLFELGFITYHRTDSTRISSTGQKIARSYLEKIGKITLLSEREWGKEGAHEAIRPVKPISPEELSEFITEKIAAYLSPMHIKVYSLIFNRFMASQMTSPVVINQKILIKNGSFQVEREVPVKLQEEGWNIFNPITVYTPFEEKKYSVVSKRTYTTHTVPLFTQASLIEEMQKRNIGRPSTYAKIVDILFKRKYIIEDVYKRLRTTALGRKVYSYLSERYMNYINEETTRQLEKLMESVETGEKDYQSVLKNLYEELNEILIKN
(1490) DNA topoisomerase 1 [Thermoanaerobacter tengcongensis MB4]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASQGHVRDLPKSQLGVDIENNFAPKYITIRGKGEIIEKLKKEAKDAEKIFLATDPDREGEAISWHIAQLLDLDIDKPCRIEFHEITKNAVQAAIKNPRKIDLNLVNAQQARRILDRLVGYKISPILWKKIKRGLSAGRVQSVAARLVCDREREIEAFVPEEYWNITAVLFDEKTSSKFEAKFYGREEEKIELKNREEVDKIINSLSEEYVVYKVKTGTKKRNPPPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGIEIKGEGSVGLVTYIRTDSTRVAKEAKEEAYRYITEKFGKEYANPDAEYSSKKANVQDAHEAIRPTSVFREPEIIKDSLTPDQYKLYKLIWDRFIASQMMPAIYDTVAMDIKNNGYIFKASGSSVKFLGFMTVYVEGSDFQEEEEEKTLPVLKEGTKVRLEELKPTQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTIATLLERGYVVKDKKVLKPTELGFIVTDALKEFFSEIVDVGFTAEMEEQLDKIEEGKVEWYEVVGDFYRDFYKTLKVAEEQMEKVELEEEVEVTDIKCEVCGRPMVVRKGRYGKFLACSGFPECKNTKPLLEKVGVKCPKCGGEIVKRRSKKGRVYYSCENAPQCDFVLWDKPVNEKCPVCGSLMVEKNTKNGIVIKCSNPECGYQKETN
(864) DNA topoisomerase 1 [Caldicellulosiruptor hydrothermalis 108]
1
MKKLVIVESPAKAKTIAKYLGKEFKVEASMGHVRDLPKSDLGVDIENGFAPKYINIRGKADVINRLKKSAESAEKVYLATDPDREGEAISWHLATILGLDVNDNVRITFNEITKKAVQESLKNARPIDQNLVNAQQARRVLDRLVGYKLSPFLWEKVKGGLSAGRVQSVATRLVVEREEEIENFKPEEYWTLEAVFKKDAQEFKAKFYGDKKGKIELKNQGQVQEIEEKIKNKEFKVVKIKVSEKKKNPPPPFITSTLQQEASRKLRFTPAKTMAVAQMLYEGVEIKGEGSVGLITYMRTDSTRISEEAQQAARNLILQKFGKEYLPEKPRVYKTKKDAQDAHEAIRPTYLDMDPESIKDSLTPDQYKLYKLIYDRFLASQMESSIYEVLSAELEVEGYIFKLTGSKLKFAGFMEVYVEGKDTEDEEEENQLPEIREGEVLKPIKLESKQHFTQPPSRYTEATLIKALEEKGIGRPSTYAPTIQTILERGYVVKEDRFLKPTELGKLVTNILKEYFKDIIDIEFTAELESNLDKIEEGKLEWTEVVRKYYQPLEKELEIARATLLKVKVEDEETDIVCENCGRKMVIKKGRYGKFLACPGYPECKNTKPYYDYLDVLCPKCGKRVIEKKSKKGKRYYTCEGYPDCDLILWEKPAKNCPKCGSLMFEKGRKGNRKLVCSNENCAYEEKIGEKGE
(1658) Reverse gyrase [Caldicellulosiruptor hydrothermalis 108]
6
MATGAKYYHSCINCGGINTDTRNEKGLPCEECLAQEQLNENIFESLKKKGSLKHYQLYWNFQQIYSMFEKFFELIFHKPMTGYQRTWARRFLLSKSFTLVAPTGVGKTTFGLVASLFSALHGKKSALVFPTISLAQQSFERLNQFKSKIQNADAIRILLFNSSMTKSEKEEFEQRFLSQDFEILIVSSQFISKRKDVLSKMFFDLVFVDDVDAILKSSKNIDTLLQMIGFSEDEIEKATERLRSKNKENGQDTVSNGSKNKGMLIVSSATAKPQGLKPLLFRELLGFEIGRFTFNIRNITNIRIKNKSNEKLLEIINILKDGILLFVNTEEEGKEIVKFLLENGIKIGATWNDFEKEFEFFKEGKLNVICGVSSYYGKLIRGIDLPSRIKYCIFWETPCFRFLIDMDKAPRFVLERVFVEYLDNHPKLKEYFKNVEYLQTEKLRQLVSKYISYEDYSKIVNKIFSHLKLTDDGKLIIPDVPTYIQGSGRTSRMFGMNLTKGVSILFEEDDTIFESLKSRLMFLLDEEWIDESEVNLESLIMEVEESRKSRNEDFNVNDTKSRLMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHGVEYHDGKFIPYYNSIKRCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEVDEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALKNPRQFNTNLVKSQIVRRIEDRWIGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKEYAKSERTFTLLKLENGYSLEIEGEEECERVKAEVVDQKIEEIPAPAPFSTSSLLSLASQKLNLGVQQIMEILQFLFEHGFITYHRTDSTRISATGQNIARMFLEKVGKKELFLPRSVGDEGAHEAIRPVKPISPEELKELAYEKYAQGISQNHIKVYQLIFNRFMSSQMKNPKVLVQKVHFRINDIEIVKDIPVKIEEEGWLEFLPMQIYPLFENKDYSITDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGYVFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEILQELYNDISVLLNK
(1688) DNA topoisomerase 1 [Thermoanaerobacter pseudethanolicus ATCC 33223]
1
MAKSLVIVESPAKAKTISKFLGKNFKVAASMGHVRDLPKSQLGIDIENNFAPRYITIRGKGAIIENLKKEAKDADKIFLATDPDREGEAISWHIAQLLNLNIEEPCRIEFHEITKNAVQTALKSPRSIDLNLVDAQQARRILDRLVGYKISPLLWKKIKRGLSAGRVQSVAARLICDREREIEAFVPEEYWSITVILSDKKNSGKFEAKFYGTKEDKVELKTKEDVDKILAALSEEYIIDKVKTGVKKRNPSPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGVEIKGEGSVGLITYIRTDSTRVANEAKAEVYKYIVEKFGKGYANPEANYVSKRANVQDAHEAIRPTSIYRDPESIKDSLTPDQYKLYKLVWSRFIASQMAPAIYDTVSMDIVNNGYVFKASGSSIKFLGFMTVYVEGTDMQEEEEKTVPVLQEGTKLFLEELKPMQHFTQPPPRYTEASLIKELEEKGIGRPSTYAPTISTLLERGYVVKDKKNLKPTELGFIVTDALKEFFSKIVDVKFTAEMEEQLDKIEEGQVKWYEVVEEFYKDFYKTLKIAEEQMEEIEVKEEVEVTDIKCELCGRNMVVKKGRYGKFLACSGFPECKNTKPLYEKVGVKCPKCGGEIVKKKSKKGRTYYACENAPDCDFILWDKPVEEKCPVCGSMLIEKNTKNVHILKCSNPGCDYQKEVK
Family distribution
Taxonomy tree
Thermoanaerobacterales