Toggle navigation
TopoIBase
Data
Taxonomy and VLD families
Downloads
My selection
Upload to selection
Selection 1
Selection 2
Selection 3
Tools
Blast
MUSCLE
VLD
About
How to use
Acknowledgements and references
Contact
Tests
Search more
Download
fasta
tsv
Download
Blast
Muscle
VLD
Add to selection
Selection 1
Selection 2
Selection 3
All selections
Taxon : delta/epsilon subdivisions
Informations
Name
delta/epsilon subdivisions
Rank
subphylum
# topoisomerases
79
Lineage and sub-taxa
Lineage
Bacteria
>
Proteobacteria
>
delta/epsilon subdivisions
Sub-taxa
Topoisomerases
Select all
Name
Family
Sequence
(1605) DNA topoisomerase 1 [Geobacter sulfurreducens PCA]
1
MSQHLVIVESPAKAKTIEKFLGPDYKVLASYGHVRALPSKQGSVDVEHDFEPRYAVLPESKRHIDAIKKELKASDSLLLATDPDREGEAISWHLLAALGVKPEKPPVPVRRVVFHEITKDAIVHAVENPRDISQDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFQSQEYWTIGAELAKEGGQKCTANLVEAEGKKLDKFDIPDQAAADRLVKALENATFTVDKVTKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMATAQKLYEGVAIDEGLVGLITYMRTDSVVLSNQALQEAHQVITSLYGPEYALAKPRFYKNKAKNAQEAHEAVRPTSIARTPAELKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGKGYRFRAAGTVIRFPGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLLKLLPEQHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLLERKYARLDSKRFIPEDVGMVVNDLLTNHFTTYVDYNFTATLEEELDQVSRGEKRWKPLLREFWEPFQGLLKQKEGEVSKADLTTEATDEACPECGKPLVVKLGKRGKFIACSGYKEGCTYTRNIDQGEGREQAEPVLSEEKCDKCGSPMLIKDGRFGKYLACSAYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPGPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
(564) DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family [Myxococcus xanthus DK 1622]
7
MLAEKPSVARDIARVLGANERGEGWLRGNGYVVTWAIGHLVGLAQPHEIRADWKKWSRALLPMLPADWPLVVSKETRSQFEVVKQVLNAPEVSSVVCATDAGREGELIFRYIYDAAKCRKPVQRLWVSSLTERAIQDGFRRLADGREYEALAAAAMGRSRADWLVGMNLSRLYTLAHGGHGEMLSVGRVQTPTLAMVVERELAIRDFVPRDYLELVATFAPRAKGVPPDALYKGTWFRSGPDGKPVAPPGFEGVREARRLDANGVEAQAIIDRVRAGRAIIESLESEEKRMAPPLLYDLTELQRHANRLHGFSAQRTLEVAQALYEKHKLLSYPRTASRHLSRTVADTLPEVVNAIRGPYEEDLAVGTGARALGKRYVDDAKVTDHHAIIPTPTAPGGVRLSPDEQRVYDLVCRRLLQAWHEDHVWRVTTVITAVTSAGAPPVVDRFQSTGTQVEQVGWKVLDIGGGQKAPRLKSEGRKGEDAEREPEDEPQTLPSGLARAQPQSVEDVEAVKKRTRPPPRFTDATLLTAMESAGRALDEKELADAMRETGLGTPATRAAIIEVLLDREYLRRRGKVMEATEKGIHLIQVVHPDVKTPAMTGQWEAWLQRIERGEGQLDEFIRGIEAYVIEVVGHGATAPQRPPRNEVLGAPPGAGWGQGGAAQVASEGAAAAHGAGAGARGPGGQGAFAESSAERFGDASAGGAGRGRQGAFTEASAERFADAAPGVQGQGRPGALSEASEPLFGTRRSRTSGSVGRSEPHGEPLSSTMSPGGGAASRLPRADGTGWNAGAWENTGAARAPVNRARTPASAASTGQRPERVRRAPTAPEALRPLLKEAFGFSDFRPYQEAVCRAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQVARLQSLGFAADRIHSGRDRAMSRQVCADYLEDRLDFLFIAPERLGVPGFVEFLARRTPALIAVDEAHCISQWGHDFRPDYRLLGARLPLLRPAPVVALTATATPDVQRDIVQQLGLQGPGGKARTFIHGFRRTNIAIEVRELNPGARGDAIQGLLEDEENRPAIVYAATRKHAEQLADQLAGEFPAAAYHAGLQPSERDRVQAEFLRGSLEVIVATTAFGMGIDKADVRTVIHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYIDRRTHEFFHRRDYPEAYVLERLFKSTAPQLEPKAVLQGRVRGDPEVFDKALEQLWIHGGVVMTPDETVMRGKPGWSASYSAQRDRKLLHLEQMGRYAEAHGCRMKQLVGHFGDTQDSGEPCGLCDVCAPEDCATLRFAEPTSAERHWLERILESLQERDGQATGRLHRELFGESLPRRDFERLVGGLVRAGLTRLEVDSFDKDGQVISFQRLALTDEGRRTRAVDPQRVVLPLPLEKAAKRKRGKGAEKGTAKRATAKKRTVRAKAGAATRRTASESDEEDSPTHWRANAPSKSTAGAPRASRSTGAPSGSASGRRAAAEPSPKMVEALKAWRLAEARKRRVPAFRILTDRVLEAIASACPENGSELMAIHGVGPSLTERYGAQILSLVARRS
(996) DNA topoisomerase 1 [Myxococcus xanthus DK 1622]
1
MGIERGTGMADAETDILTAEQQACLALWAVPGLGPRTLVALRAFADGSLAPLAATPVRDWVSQAPVSSQVRRKLASVERLAPVAWRVWEACRASGMKVAFQGQAAYPERLAEVEDAPPVLFYRGVPGLPRRRLAMVGSRHPDQGFLPFARRFARQVAASGVGVVSGAASGVDRACHWGALDEGGETWAFLGSALDALDTAQARLLPHFLDRGGVFFSELPPGVRASTTTFPRRNRLISGASDAVLVLRAGKDSGSLYTAEAGRAQGRPVFAMPGDVRQEEAAGCNALLRNGEAAVCLGPDDVWRVLKVDPLAAVPPGTMGSWEDLSAEAKGGLRDVGPGSPELRRGAGRQHLLTGGARQRAGGVGIDGAGHPAPRKAVRENLGRRVMATRTKKKVEETEAAEEKAPAKKAAAKKAAKKKPAAKKKTAAKKTAARRRTKKGDEDELPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREGEAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQISPLLWKKVRRGLSAGRVQSVAVRLIVEREDEIKAFVPEEYWTLDALLEGPAGPPPFKAKLSKLDGKKVELKERVFTESLVAELQTASFSVAKVDRRERRRNAPAPFITSKLQQEAANRLSFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFLPDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKPFFEAMGEEDMYRLYELIWKRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEGADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVMVEEETTDEVCEKCTKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRDGPYVACPNKECDYRREITEQPGGPGGSPEASSAA
(1113) DNA topoisomerase 1 [Wolinella succinogenes DSM 1740]
1
MKNLIIVESPTKAKTIKNFLGKEYEVIASKGHIRDLPKHNFGIKIEGQSFLPDYKIEKGHEAVVKEIKALAQKAKTIYIATDEDREGEAIGYHISHAIDKDPTTLPRIVFHEITQNAIKHALETPRSINMDMVNAQQARRLLDRIVGYRLSPLISSKIQKGLSAGRVQSSALKLIVDREREIRSFVPVTYFTIEALFEKGIEAELIEFEGEKLEKLSIGESKKANEMVKVLQKESWSITGIEHKRRKTSTPPPFMTSTLQQSASSVLGFSPSKTMMAAQKLYEGVMTHQGVMGVITYMRTDSLNIAKEAQEAARSRIKEVYGERYLPKEPKVYTTKSKSAQEAHEAIRPTLIDFTPQLAAQYLKGDELKLYSLIYNRFLASQMNDAEFELQTILLGSSKGVFKVSGRKLIFDGFYRVMGSEDKDKLLPELQKGEALKLEECKANRHETEPPARFSEASIIKTLEALGIGRPSTYAPTISLLAGRDYIRIEKKQIIPEEVAFKVIEVLEAHFTEIVDSHFTATLEEELDEIAESKKDWQKVLWDFYEKFDAKIALGKKNIESQKVAIPTGEMCPKCGAELVRRMSRYGEFVACSGYPKCKYIKPQESSPEQEGEESEEVCEKCGKPMVKKRGRNGEFLACSGYPDCKNTKSLKKSSTPKKVLEVKCPKCGGEIIERSSRRGNFFGCANYPKCDFISSHEPINEKCQKCGGMMAKRTYRKKEVHECIACKDRIEVEERNEEEK
(54) DNA topoisomerase 1 [Desulfarculus baarsii DSM 2075]
1
MPKNLLIVESPAKARTIGKYLGPDFIVKASVGHIVDLPPSELGVDLENGFQPHYRVIKGKDKVIKELRAAAAKAGEIFLAPDPDREGEAIAMHIAQQLGRPLESYHRVLFHELTKSAIAKAVAAPAKIDVDRYNSQQARRVLDRLVGYQISPLLWDKVKRGLSAGRVQSVSLRLVVERERAIQAFEPQEYWTVTAMLQGQQPPPFAARLARLAGKKFDPKNEKEAMAGVTAIQGQRFVVEKLTKRQRKQQPAPPFITSTLQQEAYRKLGFAPKYTMGLAQALYEGKQTSEGQMGLITYMRTDSTRLAAEAVATVRALIAARYGQEYLPAKPNAYKSKANAQEAHEAIRPTNAALTPELLEAYLSRDELRLYQLIWNRFVACQMAPAVYDQTQAEIVAGQGLLRASGQVLRFRGFTAVYVEDRDEHGGDEARASAEAKDHDQALPPLPPLDEGQELALQGVEPKQHFTQPPPRFTEASLVRELEEQGIGRPSTYAAILSTIQEKDYVSKDQKRRLIPTELGYLVNDLLVECFPQIMEVGFTAQLEGLLDQVEEGRQDWRGLLADFYGPFQQALGAAKTHMRQIKGKGVETDVKCPLCGKPMAIRLGRNGEFLACSGYPECKSTSDFSRDEKGAIVLQEAAPDPGVACDKCGAAMVVKKGRFGPFLACSAYPQCKNIMALGADGKPVAKPQPEATGEKCPKCGGELVIKPTRSGGRFISCANYPKCNYSKGLSTGVKCPKCGGELVEKRSRRGKPFYGCDNFPTCDYASWDRPIDEPCPQCGHPFLVEKVGKKETVVRCPQPDCNFKK
(1209) DNA topoisomerase [Sorangium cellulosum So ce56]
7
MIAVVAEKPAVARDIAAVLGASKRAEGFLEGGGYVVTWAIGHLVAIAEPHQIDPAWKRWRLDLLPMLPGQFPLVVLPGTRAQFEIVRKVLGRRDVERVVCATDAGREGELIFRYIYEAAGCKKPVERLWISSLTPDAIRDGLRRLRDARGYDGLADAARGRSRADWLVGMNLSRAYSLVFDQDLSVGRVQTPTLSMVVERELAIRRFVPEPYLEVVATFCPLREDASGAADESYKGTYFNDKPVPGEPPGAGERPNAGERPNAGERPNAGERPNAGERPNAGERPETAPSRRRLPPDGEEARRIIERARRGEARIEAVRSESRRLPPPLLYDLTELQRHANRLYGFSAQKTLEVAQALYERRKLISYPRTDSRHLSTEVAATLGAAVQAIEGSYRGMLAPGTGARPLGKRFVDDGKVGDHHAIIPTGARSSRAELSTDEQKIFDLICRRLLSAWHEDHVTSITTVITAITTRGGAGARGGEPIVDRYHSAGSVVEKVGWKVLDIGFGKPPARPRRKGESDGDGPDAPDARDGEGGEGERETADQRLPPGLARGQVQLVLDAEAQAKKTRPPPRFTEATLLTAMETAGSSLEEKELSAAMKDSGLGTPATRAAIIETLLRREYIVRKGKLLHATDKGVGLIEVVHADVKSPAMTGAWEAKLARMARGGGDLPSFMAGIESYVRQVVAEVSAGRRAAGGGALSPEAGASPFQERGEARSRAKGDRAAAAAPGTGRGREATPRRAPGSSAGAVPGDASAGTLQAVAAAAAASPPARAQARSRAAAPSPARPAAATARRVAVAPSTARPVAATSPPARSAAIAPSLARPAAATSPPARPAAVAPPPARAAAIGSFPARGAGTASSPAVASSPARRPEDLVELLHQCFGFSAFRPYQEAVCRTAAAGSDVLLVMPTGAGKSLCYQLPGIARGGTTLVVSPLIALMEDQASKLRACGFAAERIHSGRSRAESRKACIDYLEGALDFLFIAPERLRVPGFPELLARRKPVLVAVDEAHCISKWGHDFRPDYRMLGQRLPALRPAPVIALTATATPVVQDDIVEQLGLASAARFIHGFRRSNLGIEILEVSPGERLARVRALLGQEGRTPAIVYAGTRKDAEALAAGLSEDLPAEAYHAGLAAPVRDRIQAAFLDGSTEIIVATIAFGMGIDKPDVRTVVHAGLPGSVEGYYQEIGRAGRDGLPSRAVLMHSYVDRRMHEFFHERDYPDPAMLQRIEEVLSEEPRPKEAILGDLGIDPEVADKALEKLWIHGGARVDPDGGIALGEPGWRGPYEAQRRHKLAELVQMARFTEGHGCRMLHLVRHFGDQEDTGEPCGLCDVCAPAACAAREFRAPSRDEAQAIAKILAALRESEQPTGRLYREAFADGSLERRDFEHLLGGLVRAGLVCVREDSFEKAGELITYQRASLTSRGLLGGPRGASDVVGDVPLAKLPPKVKKRQSATSSDARRAFFARKAQRKKGRSR
(742) DNA topoisomerase 1 [Sorangium cellulosum So ce56]
1
MAKTLVIVESPAKAKTIKKYLGNGYEVFASKGHVKDLPKKQNAVDVQNDFAETYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIAFHISEEIKNPKLKVARVEFHEITKKGVDHGVHNPRKLDENLYDAQRARRVLDRIVGYDVSALVWSKLAFGLSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAKLASADGKKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQDATNYLHFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVVAKRYGKEFVPERPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLYKLIWNRFVASQMTPAVYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQEFAGEEESAGAAADGGAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPPGVITDQKFTQPPPRYNEGSLVRELEKRGIGRPSTYAEIISKVQQRAYVEKRDGGAFQPTLLGKFVVDGLVRSNLDIMDPNFTAQMEEELDAVGAGSLKREQLLKSFYKKFREQLDKSKKLAPWKPEAEKTDIVCDECGSMMLKKWGKNGWFLSCERYPKCKATRDLSDARGTAAVRETDISCDKCGKPMIIKTGRFGDFLSCTGYPACKNTRPVPLGVACPSCGGDLIEIRPRKKGGRTFYGCSNWNAEQKCEFKLWQKPVPVPCPQCGAKFVTRTAGKKAMLVCATKDCGFKQEIVEGEGEDGAADGAATPDAAAVVASAAPAPAARPAPAEPTPAGRPEAAPEGAGAAQGAAEKPARAVRARRTAS
(1758) DNA topoisomerase 1 [Haliangium ochraceum DSM 14365]
1
MADQQAISKKRANDPANQADAADDNTSAKGATSEKSASKKAASPSKKTSTKKASTKKTAKKASTKKASTKKTTKKASAKKASAKKTAKKASAKKTTKKASAKKASAKKSASQEAAEDEGESAPKRTKSRSKATKQGKALVVVESPAKARTIGKYLGPDYTVKASVGHIKDLPKNKIGVDVDQAFEPEYVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAWHIAEEIKPINDNIKRILINEITKKGVNHAIANPTVLDTNKTDAQQARRILDRLVGYEISPILWKKVRRGLSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHRWDGAKAEPKTEAQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEASRKLRFSAKRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQGTYGPEFLPAKPHTYKSPKRAQDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYTLIWQRFVASQMAPAVYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAADQDKLLPHLEEGMAIHFDAIRPEQHFTQPPPRFTEASLVKELEERGIGRPSTYASIISTITDRGYVERREARFFPTELGAIVNDLLVESFPKIMDVDFTAAMEADLDKVEEGERDWRELLGGFYEPFRGNIEHAKENMRDVKREEIPTDHVCEKCGAPMVIKWGRNGSFLACQAYPDCRNTKEINRNPDGSFEIVPEQTTDETCSECGAPMVVKRGRFGAFLACSTYPECKNTQPISLGVDCPKDGCGGFLTEKRSRRGKPFYGCSNYSKTGCDFVTWDRPIAEACPVCEASFLVKKETRRGTTVRCLSCDYKTEQAGESAA
(993) DNA topoisomerase [Haliangium ochraceum DSM 14365]
7
MTATTLIIAEKPSMARDIARVVGARSKREGYLEGGGYWVSWCIGHLAELCEPHEYDAKWKSWSPSLLPILPDELRVRPSRSGAAHLRVLHRLMRAREVGTIVNACDAGREGELIFRHVHALSNTRKPVRRLWISSLTGEAIRRGMSALRPGAEFDDLADAARARADADWLVGMNATRALTGLVRSGGTRGLLMSVGRVQTPTLALIVRREREIESFESKPFWQVLATFAVPGEAGASYEGIWQRPREAGDDAGDAQRDNKGDAQRDNKGDGDTNTARDRSRVPTRQQADAIADAVRGRAGTITQLTRKSTRERPPLLFDLTNLQKLANRRFRMSAKRTLELAQALYETHKLITYPRTDARYLTDDLAPTLPELVRALAGEYPGLRDTALAGAAHAAGNRRIFDNAQVGDHHAIIPTAKAPSPGRLSADERRLYDLIARRFLASLFPDAVYDQTKIVTTVAGHCFATERRVCAEPGWQQAEPPPPAKRNEPPLPRLRQDMEVDTAAIEVREGKTQPPKRYSEASLLGAMEHAGRSLDDPGLRRVMRDAGLGTPATRAAIIETLLKRSYIERQGRELVPTEQGRALIASVPIEDLLSAELTADWEQKLDAIARGRASKARFMDEIHGYVRRIVDALAQATPPSLPSPTDEVLGLCPVCNGVVTEGFKTFQCASGKSCSFVIFKRIAGRKTSAALVRVLLARGRTQTLKGFRSKRGKRFSAVLTLDAEGKVQFAFDNPRGGATKSAGSAKGAKKSASSASGAKKSAASASGAKSAAAGGSGPRCPACRQGRIITGRRAWGCSRWREGCGFTVGFQQGEVRVSEEQAERLFRRGQTVLLDGLMPERRARLVLDLEAEGNVRVEPGKRARRT
(670) DNA topoisomerase III [Stigmatella aurantiaca DW4/3-1]
7
MGTAPEQEKTRQAGGGVAPRGPSSVLAVVAEKPAVARDIARALGATQRGEGWFRGNGYVVTWAIGHLVGLAQPHEMHPAWKRWHREQLPMLPSTWPLVVSENTRTQFEVVRAVVNAPEVSGVVCATDAGREGELIFRYIYEAAGCRKPVKRLWVSSLTEGAIREGFRTLKDGRAYDALADAAKGRSRADWLVGMNLSRLYTLACGETLSVGRVQTPTLAMLVERELAIRDFVPEDYLEVVATFAPQAAGVPAGTQYRGTWFREAEPKGGPRTAETAREARRLPADGVEAGEVMARVRSGAAVIESLTSETKRMAPPLLYDLTELQRHANRLYGFSAQRTLELAQNLYEKHKLLSYPRTASRHLSSAVAETLPEVVRAIRAPYEPLLAPGTGEKPLGRRFVDDAKVTDHHAIIPTATSPEGERLPPDEKRLYELVCRRLLAAWHDEHVWAVTTVVTAVSSVGPAPGSPRVDRFHSSGTQVVRVGWKVLDIGGGQRPPKGREGKGPKEEGEGKEPEDEPQDLPAVLARGQKQRVEDVEAVKKRTRPPPRLTDASLLTAMETAGRTLDEKELADAMKETGLGTPATRAAIIEVLLEREYLQRRGKSLEVTEKGIRLIQVVHPDVKTPAMTGQWEAWLQRIERGQGDLQAFLRGIEAYVIEVVGKMPAQPMPPRAEGPRPPPPSGAPASGAPPASVPAVSVAARAPLSAPRPASPSPSSPAAMRVRVEAPQGASKRSVERTPRAPTPPGELRKLLKEAFGFEDFRPYQEEVCKAATAGEDLLLVMPTGAGKSLCYQLPGLARAGTTLVVSPLIALMEDQVTRLQSLGFAAERIHSGRDRAASRQVCTDYLEGRLDFLFIAPERLGVPGFVELLARRPPALIAIDEAHCISQWGHDFRPDYRLLGARLPLLRPSPVVALTATATPDVQRDIVQQLGLRGSRGGASRTFIHGFRRTNIAIEVRELNPGQRGDAIRDVLAEPENRPAIVYASTRKHAEQLAERLAEEVPTAVYHAGMTPADRDRVQSAFLSGRLEVIVATTAFGMGIDKADVRTVVHAALPASLEGYYQELGRAGRDGKPSRAVLLHSYVDRRTHEFFHQRDYPEPSMLAKLFHAAGAGLEPKEALQARVRMDPEVFDKALEQLWIHGGLEMTPDENVRRGRPEWPAPYTAQRERKMLHLEQMGRYAEASGCRMRHLVSHFGDVQDSGKPCGLCDVCAPETCVTLRFAEPGERELQALGRILDALHERDGQATGRLHRELFGEALPRREFERLIGGMVRAGLTRLSEDSFEKDGQSISFQRLTLTPEGQRTRVIEPDLVMLPMPLEAKSAKKRRATRGKAAGARLEKPRRAGTRGPPVGHSAGSASEGRQRPVAVPWGGTRERAGAVTGRSSKALSVVREWEGMDAPPATEEDWDEEQDIGVRRGGRRQPMPLPKPSPALVEALKAWRLAEARKRRVPAFRILTDRVLGAIAAARPEDREALMAIQGVGPKLVERYGAQLLALVGR
(1289) DNA topoisomerase 1 [Stigmatella aurantiaca DW4/3-1]
1
MATRKKKADETGTEAEETAAKKKAKRPAAKKAAAKKKSATKRKGSASLATVEVSADEEEEATPRGKGPHYLVVVESPAKAKTIKKYLGTGYTVKASVGHVKDLPKSKIGVDVEHDFQPEYQVIKGKEKVLNELKKAAKAVDKVYLATDPDREGEAIAWHIFEELGHKDSYRVLFNEITKKAIQEAIAQPRHLNQESYDSQQTRRILDRLVGYQISPLLWKKIRRGLSAGRVQSVAVRLICEREDEIKAFLPQEYWTLDALLEGASGPPPFKAKLSKIDGKKVELKDRETTDALVAELQGAEFTVAKVDRRERRRNAPAPFITSKLQQEAANRLHFTAKKTMTLAQRLYEGIPMGEEGQTALITYMRTDSTRLSDDAVKQVREFIGNQYGGDFLPEEPVSYRSKKNAQDAHEAIRPVSLEYPPERVRPFFEQMGEQDMFRLYELIWNRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLRVYGAGLTPEEEAEKEKAKAAGDEATDSDEATGELPPLNDGDKLRLQKLLNEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGVMTNEMLVKHFPKEMAVAFTADLEEKLDQISEGGASWKAVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNPLVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVIVEEETTDEKCENCGKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVNCPECKQGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEACPQCQSPYLLQKFSKRDGVYVACPNKECDYRREVQQPADATAPSAA
(1415) DNA topoisomerase 1 [Anaeromyxobacter dehalogenans 2CP-C]
1
MAKEPKTGAVAVKKKKAAAAPKEATAVAEAEAPKTPRRAARKTSTGTSLVVVESPAKAKTIKKYLGRAYDVKASVGHVKDLPKSKIGVDVEKGFLPEYDVIKGKAKVLSEIKRAARTADHVFLATDPDREGEAIAWHISEELGSEGGDARVRRVLFNEITKTAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFVPVEYWSLDADLAAQVPPDFRAKIFKVDGQKADLKQGEETLALVKELEGARYVVASVDRKERKRNPPPPFTTAKLQQEAANRLGFSPKKTMTLAQRLYEGVELGDEGAIGLITYMRTDSVRLATEAVDAVRAHIQQAYGKDHLPEQANVYKTKAKAAQEAHEAVRPTSLEWTPDRVAPFFDQMGERDMYRLYELIWNRFVACQMVPAVYDQTAADIAAGRAVFRATGSILKFPGYLAVYGAKPPEEEAGAEEEKSNGDAAEPAARAEDRQLPPLEAGMELRLLKLLPEQHFTQPPPRFNESSLVKEMEERGIGRPSTYAAILDTIQEKGYVEKLEKQFKPTHLGVLVTDELVRAFPREMDIAFTASMEEKLDEIEEGSAGWQRVLEEFYVSFKEDLAKADEAMRNVKAQAIETDITCEKCGQHKMVIKWGRNGEFLACPGYPECRNTMNFRREDGNIVPEKEEDVPVEDKCPECGADMVMKRGRFGRFLACTRYPDCKGTKPVSIGVTCPKGCGGYISEKRSRRGKTFYGCSSYPKCDFVAWDRPRNETCPQCGSAYLLDKYSKKTGPFVACPNKECGYRREAEPREGGAAAAQVEPAKA
(1144) DNA topoisomerase 1 [Anaeromyxobacter sp. Fw109-5]
1
MPRATKAAAAAEGVKAEGVKKEKAAPPKRAAKKVAQGGSLVIVESPAKAKTIKKYLGRSYDVRASVGHVKDLPKSKIGVDVEAGFTPQYDVIKGKAKVLSEIKRAARSAERVYLATDPDREGEAIAFHIAEELGDSGDGRVRRVLFNEITKNAIQKAIEKPLDLDRKKFDSQQARRILDRLVGYQISPILWKKVRRGLSAGRVQSVAVRLVVEREREIEAFKPEEYWTLEAELAAKLPPEFRARLSKVDGQKAELKEGAVTHALVKDLDGATYVVATVDKKERRRNAPPPFTTAKLQQEAANRLGFTAKKTMTLAQKLYEGVELGDEGAVGLITYMRTDSVRLSTEAVDAARGYIAEAYGQDHLPEAPNVYKTKAKAAQEAHEAVRPTSLEWTPARVAPFFEQIGERDMYRLYELIWNRFVACQMVPAVYDQTTADITAGRATFRATGSILKFPGYLAVYGAKPPEDEAGAEEEAKENGDREKANEERQLPPLEAGMILDLRRLLPEQHFTQPPPRFNESSLVKELEQRGIGRPSTYAAILENIQEKGYVEKVERNFKPTHLGLVVTDELVKSFPREMDLAFTAGMEERLDEIEEGNAAWQQVLKDFYDSFKDDLAKAEVNMRDVKRQEIATELTCEKCGKPMVIKWGRMGEFLACSGYPECRNTMNFKRGEDGTIVPEKEEDVPTDEKCPECGAAMVMKRGRFGRFLACTRYPECKGTKPVSIGVSCPKGCGGYISEKRSRRGKTFYGCSSYPGCDFVSWDRPRNEACPQCGSAYLLDKYSKKTGPYVACPNKECGYRRDAEAKAPGAASEA
(1736) DNA topoisomerase 1 [Desulfovibrio africanus str. Walvis Bay]
1
MAKNLIIVESPAKVKTIKKFLGRDYMVEASVGHVRDLPPNKIGVDEERGFTPDYKVIPGKQKVVAKLKAAADQAEHIYLAPDPDREGEAIAWHVAHLIGDKNKQVSRIQFNEITSRAVKEALDNPRPLDENLFHSQQARRILDRLVGYKLSPLLWSKVKRGISAGRVQSVALRIIVDRERERQAFRPEEYWVFKALLEGPEPPAFAAELWKVEGKKPSVGSGEQAQVLYDRVKDTPFVVSAIEEKERQRHPSPPFITSTLQQDASRRLGYTAKRTMSTAQRLYEGVELGESGVTALITYMRTDSVRVADEARDAAQAFIVETLGADYYPPKPRYFKTKSGAQDAHEAIRPVDVRVTPESVRKHLPADQYKLYTLIWQRFMASQMAAARLHDTTVTVDSGPAQWRAKGERVLFPGFLKVYGVDEATDEKTEGEGGESTSTKAAMLPKLEKGMQLTVRKLTKDQKFTQPPPRYTEASLVKELEEQGIGRPSTYAAIISTLLDRDYARLEEKKFVPSELGVTVVDLLTKHFQSLMDVHFTAGMEEQLDDVAGGKVNWVELLKHFTGDFYPTLDKAKDEMVQVKGGLETGIVCDLCGKPMNIRFGKNGEFLGCSGYPDCKGIKNFTRDEQGQIQIVERANEMPEKVGTCPDCGKDLVLKRSRTGSRFIACSGYPECKHAEPHSTGVTCPREGCTGQLVEKSSKRGKVFYSCSTYPKCNYATWDWPIAKPCPQCDSKILTIKTTKARGEHVACPEKACRFTRELEPDESVG
(262) DNA topoisomerase type IA central domain protein [Desulfovibrio salexigens DSM 2638]
3
MRLFIAEKRDVALAISQALGGPDRPTGAAFQVNGDRITWLWGHVLRLTDPEEHDERYKLWDLNTLPMKWPVTYAPESKHVDHLKKIIELAHQADELVNAGDPDPEGQRLVDEVIEFAGLLEKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAVCDQRYGYNLTRCYSTLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQIDMPSQLVEAEYIPADDAPVDEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPLPYNLLALQADAAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQALTPAFGDMAEYAAPNLKSKAFNSKKVTAHHAIIPTMNVPELGKLNEDERRIYTLIVKLYIAQFYLPAEFVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHKLQQNDSGTVESAESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDESGGIGTPATRDSHIETLFRRGFVAEKSKKVISTELGREFHDALPEFAVKPDMTALWHEKQKQIEAGELNYLQLIEEVDGSVAQEIARVKREGINIKSSAVQCPKCKTGFLKPRKGPKGKFWGCSAYPDCNATFPNKAGKPDLKAKPAKKLAASKEHKCPDCGKGLIRRPAKRKGLFWWSCSGFPECKFRCFDEKGKPKLES
(1384) DNA topoisomerase 1 [Desulfovibrio salexigens DSM 2638]
1
MSKDLIVVESPAKVKTISKFLGRNYQVAASVGHVRDLPKNKLGVEENGDFTPQYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIGWHVAAIIKEVNENVSRIQFNEITARAVKEALEHPQPLNEQLFDSQQARRILDRLVGYKISPILWKKVKRGISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWKVDGKKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDANRRLGYSAKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVILDKYGDEFYPAKPQVYKSKGGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNRFIASQMAPARFWDTVVTIQAKNTIWRSKGERLLFPGFMRVTGKTGDEKLIELPKLEKGEVLKVDKIESEQKFTQPPARYSEASLVRELEEKGIGRPSTYASIISTIQDRGYVNLEEKKFIPTELGFVVSDQLSEHFKELMDVGFTAAMEKQLDDVADGKIEWTSLMKDFVDGFYPTLETAAKEMKRGGEDTGITCDKCESPMVIKFGRTGEFLGCSNYPECKNIVNFTRDEKGKIVVLEEEPPEETGVTCEKCGSAMAIKRSNRGEFLGCTGYPDCRNIKNFERDDEGKIKVVETPTAQIVGKCPDCDDGDLIIKHARTGSRFIACSNYPDCKHAKPFSTGVKCPREGCKGELVEKSSRRGKLFYSCDQYPDCDYAVWYPPIDGPCPKCGHPVLVKKTTRAKGEHIACPEKGCGYVQGEEES
(24) DNA topoisomerase 1 [Desulfurivibrio alkaliphilus AHT2]
1
MGKSLIIVESPAKARTLQKHLGKDYLVKASVGHIRDLPVSSLGVDIDHDFAPQYVTIKGKAKVISDLKKAAKEADQVYLAPDPDREGEAIAYHIAEALKTTRKPIRRVLFHELTHKAVLAALEKSGEVDHHLFEAQQARRVLDRLVGYQISPLLWDKVRRGLSAGRVQSVAVRMVCEREEEIEKFVSEEYWSITTTLAGPQPPPFQALLEKVDGRKLDNRKRKIADEAQARELVLQLMAAELKVAGVDKKQQRRRPSPPFITSTMQMDANRKLRFSAKKTMAQAQRLYEGIDLGKEGPVGLITYMRTDSTRVNDEALGMARDYIGSTYGADYLPAKPVQYKTGKGAQDAHEAIRPTDVSRTPESLAGKLDKDMLALYTLIWKRFVASQMAPAIYDQTSIRIAGGPEGRHELKATGSIMRFPGFMTLYVEAVDETPEEGKQSGKGGKDALLPDLQEGQLLKLNEITPKQHFTQPPPRYTEATLVKALEENGVGRPSTYAAILSTIVDKEYVRLTQRKFYPTDLGRMVNKLLVAHFPKVIDTDFTAKLEQELDEIETGKVDWVQVMREFYGPFQQNLEQAREEMKAVKHSAIPTGLNCPQCESELVIKWGRKGEFLACSNYPECKHTQDFTRDEEGKIKPLEREAPEESGESCDKCGKPMVYKHGRFGKFLACSGYPDCKNVRAISTGVSCPEDGCDGEIVQKVSKRGKVFYSCNRYPKCTYALWDKPVAKPCPLCSSPFLVEKSSKKGRRLACPNKECRYSEELPEEGE
(1362) DNA topoisomerase [Desulfovibrio alaskensis G20]
7
MSKILIIAEKPSVAREIAPLVGAVSRRDGFLEGPTHIVSWAVGHLVNIAEPEEQDEAWGGRWALEQLPMIPRQFRLTVLPEARRQYETVRQLMHRDDVAHVVNATDAGREGELIFRRIQLHAGCTKPVQRMWANDMTEEGLRRSLGNLLEDAAKRNLGLAAFARAEADWLIGMNLSRLFTLKAGSLISVGRVQTPVLKLICDRRAEIEHFVPSDFWTVEARFGRSAPCNAGGAAAAAGSAAPVCLSAGAADAQGAEKHPPQAAAATAGQASCPPDENADARGTGTETPADDVFSAVWHLPPDFKETRLERQDDAEAVIGRCQGGTGVVDATENRKGSQKPPLPFDLTTLQREANSRFGYSAKETLAIAQALYEQRKLITYPRTDSRYLTRDLFKEILKHFRAVYHLYPQETVPAVERVKAGCKFDCVNDKKVTDHHAIIPTAAKGRPDALSAEERNVYDMVCRRFVAAFSAPASFMSSTVRVLSGEDVFVARGKVFKDIGWLAVEPWRTAEDNPLPALRKGTRLHVHEVSAVRRQTKAPAHFTDASLLAAMETAGRLVDDEELRNAMKERGLGTPATRAQIIETLLARGYVEKKGKRLIATDSGMQAAALVSSMLPDMASAELTGLWEKKLKDIEAGNNTYPLFMQEIRTMLAQSVESIKPRNVKNILVETAARLASRELDGKCPLCGAEVEERDKGFGCSRWKRADGGCPFMIWRTFMGTQIDAGMVRELLETGCTSQELQLTSRGGNTFSARLRLEQGRVRPDLPEKHARASGGAAPSAGVDMHDPAENPFFADENPFPPEMP
(493) DNA topoisomerase 1 [Desulfovibrio alaskensis G20]
1
MGKDLIIVESPAKVKTIKKFLGNKYMVQASVGHIRDLPTKELGVDEENDFSPDYQVIQGKQKVVSALREAAAKADNVFLAPDPDREGEAIAWHVAEIIAKENKNISRIQFNEITARAVREALENPRELNRSLFDAQQARRVLDRLVGYKISPILWNKIKRGISAGRVQSVALRLIVDRERERYAFTSEEYWVFRANLAAETPPPFKAELFKVDDKKPAIASAEQAQELEKSIEGKAFIVDSVQEKERSRKPQPPFITSTLQQLASQRLGFSAKRTMSVAQRLYEGLDLGDMGTTALITYMRTDSVRISDEARDSARELIASLYGKEYCPAKAPVYKTKGSAQDAHEAIRPVDVTLTPDKIKGLVAPEQYSLYRLIWSRFMASQMAPARFHDTTVLIGCGGTQWRVKGERLLFPGYMAAAPASAKEANVELPPMQQGQTLELTLLEKEQKFTQPPARYSEASLVREMEEKGIGRPSTYASIISTIVDRDYTRLEEKHFVPTDLGFVVCDMLTNHFGTLMDIGFTAQMENSLDKVAEGDLDWVALMKDFTSDFNPTLASAAKEMKTVKAGLETDIVCSECGKPMAIKFGKAGPFLACTGYPDCKNTSNFTRDESGTIQLVEREQEELKPVGTCPECGKDLVVKQARTGSRFIACTGYPDCKHTEPFSTGVPCPNDGCDGQLVEKSSRRGKIFYSCNRYPQCDYATWNWPVAEACPQCDSKILTIKSTKARGKHIACPACKYTRALEDEE
(154) DNA topoisomerase 1 [Desulfovibrio magneticus RS-1]
1
MGKDLIIVESPAKVKTIKKFLGNAYAVEASVGHVRDLPSKKLGVDEKDDFAPQYQIIPGKQKVVSKLKEAAASASTIYLAPDPDREGEAIAWHVAQIVQEAGVPVHRIQFNEITAKAVREALSHPRDINEKLFLSQQARRILDRLVGYKVSPILWQKVKSGISAGRVQSVALRLVVDREKERRAFVPVEYWNFKARLAADSPPEFEAELAKYQGKKLEIGSAEAAAAAEAAITGQPFVVTAVTEKERKKSPPPPFITSTLQQAANQRLGYSAKRTMGAAQKLYEGLELGDSGTVALITYMRTDSTRIADEARDAAREYITEALGPDYYPEKARHFRSKAGAQDAHEAIRPIDVRITPADVKTLLPKDLFSLYKLIWERFVASQMAEARFWDTAVDVTAGPGLFKAKGQRLIFPGYLKVYGQEAGDEAKSLPKLDKGQELTLLELKKEQKFTQPPPRYTEASLVRELEEKGIGRPSTYAAIISTLIDRDYARLEEKHFVPSELGETVSDLLAEHFVKIMDVGFTAGMEEALDAVADGRTDWVNLLKDFTEDFNPTLAKAAKDMAKVKAGKETDVKCELCGKPMVIRFGKAGEFLGCSGYPDCKNTKEFDRAPDGAVIPRERKAEEVASVGACPTCGKDLVVKKSRTGSRFIACTGWPDCKYTKPLSTGVPCPKEGCSGTLVEKSSKRGKVFYACDAYPQCDFAVWDWPINEPCPQCDSKILVRKKTRDGELITCPSKSCRYKRAVGGKKDEGEGEE
(1863) DNA topoisomerase 1 [Campylobacter lari RM2100]
1
MKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDENFKPEYRISSDHSTLVKELKEKAKNAKQIYLATDEDREGEAIAYHIAKAINKDENSLPRIVFHEITKSAIENALNNPRHLDINSVNAQQARRLLDRIVGYKLSPLLNQKIQKGLSAGRVQSAALKIIVDREREIKAFTPLKYFSIDVIFKKDLEAELVEFQGQKIEKFTITNEDRAKLIFENCKNAKFKINNIESKDRKITPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVKTHQGIMGVITYMRTDSLNIAKEALEQVRKLIKDEFGKEYLPAKANIYTTKAKGAQEAHEAIRPTNLSFTPKLASEFLEKDEARLYTLIYNRFLASQMNPAISQTQNVYAKSNEASFKISGRKILFDGHYKVYGDMDKDKILPNLKLEDTLNIQNIEFNSHFTEPPSRYSEAGLVKKLENLGIGRPSTYAPTISLLSARDYVRIDKKQLIPNEIAFNVIEVLEQNFSDIVDSDFTFKMEESLDEIAEGKLDWQELLREFYFPFMRKIDEGKKNIKSQKTITKIDETCPDCGGELAIRKGRYGEFIACLNFPKCKYSRNLKQENKNEEKTQIKQVNSIGLTCPECKKGEIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGENLIIKELKKGTFLECLKCKIKKEI
(553) DNA topoisomerase 1 [Desulfomicrobium baculatum DSM 4028]
1
MGKDLIIVESPAKIKTIKKFLGGGYEVEASVGHVRDLPTKTLGVDEGNDFAPDYQIIPGKAKVVSKLKSAAKAADTVYLAPDPDREGEAIAWHVAEVIRTSNPNVKRIQFNEITAKAVKEALANPTELRKPLFDSQQARRILDRLVGYKISPLLWKKVKRGLSAGRVQSVALRLIVDRERERQAFVSEEYWVFKITVQGETPPPFDADLWKVDGEKPVIGDEKTALALESRVDGQSYVVRDIVEKERQRHPRPPFITSTLQQDASNKLGFNAKRTMSVAQRLYEGVELGERGTTALITYMRTDSVRISDEAKDGAREWITRTLGPEFYPKEPRVYKSKGSAQDAHEAIRPVDPSLTPDSIKNNLPPEQYKLYRLIWERFMASQMASARFWDTVATIESGPAQWRAKGERLVFPGFLQIWPQSSDNQSALLPKLVTGQELRLEKLHKEQKFTQPPARFSEASLVHKLEELGIGRPSTYAAIISTLTERDYVHIEEKHFQPTDLGVIVCDLLVEHFAHLMDAGFTARMEESLDHVAEGETDWVALLRDFTLDFNPTLDKARENMTQVKAGMDTGLSCPQCEDGRLVVKFGKNGTFLGCANYPACSFTSNYIRNNAGEIELVKEEAPEELGPCPKCEDGRLVVKKTKTGGRFVACSNYPACRHTKSVSTGVACPKDGCDGELVEKTSRRGKPFYSCSKYPKCDYAVWDFPVAKPCPLCESKILVRKETKARGAHLACPVKDCGYWEKLD
(1398) DNA topoisomerase [Desulfomicrobium baculatum DSM 4028]
7
MPRTLIIAEKPSVARELAGVLGVKGRGDGFLQGPGHIVTWAVGHLVNIAEPAEQNPAWSGRWSMRQLPMLPSRFTLGILPSTAKQYEIIRNFLLDDDIDSVVNATDAGREGELIFRRIYLLAGSTKPIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAAFARAEADWLVGMNFSRLFTLRAGSLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGEFAHEGETFKATWFAAPDFKDSKIWQVEEGQTVVQACAGKDGAVLEMEKKKGRQKPPLLFDLTNLQKEANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVYAHFPEISQSAAANIKDAKKKFECVNDKKVSDHHAIIPTTLRANPATLGKEEWAIYEMICRRFAAAFMDDATFASSTLWIGVEGHRYRATGKIFQDKGWLEAEPWRASEDNPLPNLRKGAAVTAQSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKERGLGTPATRAQIIETLLARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVASPELTGEWEKRLKEMEQGGYAYGVFMHQVREMVSSGVSRVKGSNARPPACPVVSDRKPSKEVNS
(1558) DNA topoisomerase 1 [Bdellovibrio bacteriovorus HD100]
1
MAKKSDATDGIKLVIVESPTKAKTIRKFLGRDYVVESCMGHIRDLPQSAKDIPEKVKKEKWAQLGVNVDKNFEPLYCVPKDKTKVVKNLKDKLEEASELYLATDEDREGESISWHLLEVLKPKVPTKRMVFHEITKDAIQKALKDTREIDFNLVRAQEARRVLDRLVGYTISPLLWKKVAYGLSAGRVQSVAVRLIVERELERVRFKKSSYWGVLAELSKDGVSFESRLQQYKNQRVATGKDFDGLTGQLTAGKDVLVLDEKTAGKLSMDLKSGNWQVTDVEEKPTFRKPAPPFITSTLQQESNRKLGLSSRETMQVAQKLYEQGFITYMRTDSTFLSNEAITASRDCIESKYGKEYLTPQPRNYAAKKVKGAQEAHEAIRPAGNQFMDPDETGLTGTQFRLYDLIWKRTIASQMVDARQKQVSAKITVGDALFGASGMTIEFPGFLRAYVEGSDDPEADLAEREVRLPALKVKDGVKCAKLDPTSHETKPPARYTEASLVQTMEKEGIGRPSTYASVIGTIIDRGYVRKNGTALVPTFTAMIVSKLLSQYLSQYVDLGFTSEMEQSLDNIADGELDWESYLASVYKGPKGLRAMVDNQGDKIDPNEARTMTLEGMDKYKFHVGRYGAYVTTQRDGEDVSASLPDNESPADITPEIAEKLIDQKINGADSLGNDPETDLPVYVLNGRYGPYVQLGDVTPEDDKPKRASLPPGTQPEQVDLAMALSLLQLPKTLGTHPGTGKDIKAGLGRFGPFVVHDGDYRSIPKGESIFNITFEKAMEMLAQPKKGRGRAAPLKELGAHPDSGDAIQVFNGPYGPYIKCGKVNASLPEGATPDTVTLEQAVALINEKGPAKGKGKAKGKAKAAPKAKAAKADGEKPAAKKPALKKAANAKEKAEALGVKKVVTRKSKK
(1499) DNA topoisomerase 1 [Bacteriovorax marinus SJ]
1
MKRASPFHLNKDVIMASSEAVEETKSSKKTAKKTAKASSKKKTTKKKTTTSKKKTAKKKTAKTTKKKTTKKRDLGDYSLVIVESPSKAKTIKKYLGKGYQVVASNGHIKDLPKSKLGVDIKENFQIDLVPITGKKDKIERIQELAKDATAIYLAPDMDREGEAIAHHLAEEIGKKKKMYRVVFNAVTKSAVNNAIENPTELNKSMYESQQTRRILDRLVGYKISPILWDKVQRGISAGRVQSVALRIIVEREDEINAFEPEQWFSIHGVCEKDAQKFEVKYYGESATKKTDLTEKDLVDKILSDVKGKSLDVIDVKKKERKQNPTPPFTTSKLQQEAANKLGFTAKRTMMTAQKLYEGIQLTEHGMQGLITYMRTDSVRTAPEAMGALREFILDKYGKDYLSVEPIEYKKKGSSKVQDAHEAIRPTNLAFTPDSVRGDLEPDQQKLYELIWNKFISSQMSQAIIDQTTVMMEREGHFFKANGSIIKFPGFRTVYLEAAAEKRSRKGGDDEDDNDAGEVKSGLLPVINTGESFTPIEGPTEQEHWTSPPPRFNEASLVKSLEEFGIGRPSTYAAIISNIQDRGYVEKTENRFLPTELGIVVCRMLVESFPNVMDIKFTAGVEELLDQIEDGTIKYKKVLKEFWKEFEVTLEKAKEEMKNLKKQLIPTGINCLKCEDGEYHIKWGRNGQFFACSNYPDCNSTQDFKKHLDGSYEILPKNWFHDNCPNCQKRLEVKKGKYGRFVRCEDYPQCDTTLPYTLDITCPECNVGKFAEKKSRYGKIFYGCSNYPNCENASWTKPYVQDCPSCGYGIMGFKETKRDGKHLECAKCKFKLEWEQTKYGKEELEKQRQEEEALKGSH
(1533) DNA topoisomerase 1 [Geobacter daltonii FRC-32]
1
MPQHLVIVESPAKAKTIEKFLGPDYKVLASFGHVRALPSKQGSVDIEHDFEPKYAVLPESKKHIDAIKKELKQADVLLLATDPDREGEAISWHLLAALGLDKKPNIDIKRVVFHEITKGAIVNAVENPRGISHELVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFVEQEYWTIGADLSTAGKQNFTANLVEADGKKLGKFDIPGKEAADKLIEILDKATYSVEKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSIAQKLYEGIDIGEGTIGLITYMRTDSVVLSQQALDEAHQVITSLYGKEYALAKPRVFKNKAKNAQEAHEAIRPTYISKTPVELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVEISAGKGYKFRVAGTVIRFPGFMKLYIEGVDDETEEKEGVLPPLNEGDSLQLRDLLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYARLDKKRFFPEDVGMVVSELLVNHFTKYVDYNFTASLEEELDQVSRGEKKWKPLLHEFWQPFHNLLKQKEGEVNKSDLTTEATDEICPECGKPLVVKLGKFGKFFACSGYPECKYIRPLDKDKKESAEPVFSEEKCEKCGSQMLIKEGRFGKYLACSAYPACKNMQPLVKPKGTGIKCVECGEGELTEKKSRYGKMFYSCNRYPQCKFALWDLPVEKPCPKCGFPLLVKKVYKREGEFLKCPKDGCDYKEGGKEK
(1416) DNA topoisomerase 1 [Desulfococcus oleovorans Hxd3]
1
MNKPVIIVESPTKVKTITKYTGNAYSVTATSGHLRDLPPHELGIDIDNGFAPDYVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIAFHVADLLKKKGRRFHRVMFHELTKTGIQKGLTEPTELNRNRYDAQQARRILDRLVGYQISPLLWRKVRNGLSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVKKGTKNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAIRKLGFTAKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPEAAHEALAHIRSVFGNDYAPDRPRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKRFVASQMSEAQIDQKTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDKLPQLDEKEVLKLIELDPKQHFTTPPPRFSEASLVKELEENGIGRPSTYATILSTIRDKGYVDLINKAFRPTELGFIVNDLLVENFPTILDIEFTANMENDLDRIESDQLQAVRLLERFYGPFSQRIEAAKDRMRSVKGVGMDTGLSCPECGKELKIKLGKNGPFLACSGYPDCKFSRNYARTDKGTVEPVEPDLTVAEGKSCEKCGSPMVVKQGRYGDFLACSAYPDCKSTQSLNSGANAAPIGVKCPEPGCNGDIVEKKSKRGKVFYGCSRFPKCTFASWDKPVDMACPDCGAPFVVEKTTKKEGTVLTCASEGCGFRQRT
(72) DNA topoisomerase [Desulfobulbus propionicus DSM 2032]
7
MGKTLIIAEKPSVAADIVKALPGKFTNAKTHYESDEYIVSYAIGHLVSIAYPEEINPELNKWTLDNLPILPEEFPLAVLPDTKAQFNALTKLIRRRDVEVIVNGCDAGREGELIFKYILKQATNRSVEHKRVQRLWLQSMTLDAIRDGLGKLKDDQEMRPLEDTALCRSEADWLIGINATRALTCYNSRFGGFRKTPCGRVQTPTLSLLVKRETERREFVPTTYWELHGCFVCGPVAYQGVWIDPAFAKDEEQAHGRRNRIWEEERAKEIADRCTGKPAMVEESSKKSTKGAPPLYDLTLLQREANSRFGFSAKNTLALAQALYERHKLITYPRTDSRCLPEDYLPTVVKVVGQQQQWQYGRFASEALEKKYLKKDKRIFDNKKISDHFAIIPTAGLPKTLSEPELKIYQMIVQRFLAVFFPAAVYHNTRRLSLVEGETFLTEGKILVEPGWRAIYGASSEEDGDKELQALPPDTLVQCEDIDRQEHQTKPPPRFTEATLLSAMEHSGKLVEDEELAEAMKERGLGTPATRAAIIEKLINEKYIVREQRELVPTGKAFELLSLLEARKIDVLASPELTGEWEYKLNQILKGAMTRTQFMKEIREMTGAIVDKVKQGGGTERHEAPFSPVDGARFYETASAYESEDKKLIIRKVLGGRVMDPAEIVELIRGKTLGPFNDFRSKKGKPFTASVHIANSKVEFLFADSTDELNLDEIRGQEPLGLSPVDQTKVFETPAGFLSESALEGDQKKGLRISKIILGKKLEREHISQLLADGRTELIGGFISKRKKPFDAFLLLDAKGKLSFAFPPRGKKGKDKEADNG
(1500) DNA topoisomerase 1 [Syntrophobacter fumaroxidans MPOB]
1
MSKSLLIVESPTKAKTLGRYLGKDFIVKASVGHVKDLPKNRLGINLEKDFQPEYQVIRGKKKVISELHEAAAKSGAIFLGPDPDREGEAIAWHIAEEIGATDKPVYRVLFYELTRKAIQEALAKPDRLNRELYEAQQARRILDRLVGYMISPILWQKVKRGLSAGRVQSVALRLICAREKEIRDFDSREYWTITALLGTQASADAPAKSASRRFKAELFRCGKKKCTISTGEEARELVDRLRPLDYRVSKVERRKKKRHPAPPFITSTLQQEAARKLHFSARQTMNVAQRLYEGLELGKEGAVGLITYMRTDSTRLSADAVQAVRDYIAGHWDKAYLPAKPAAYKSKAGAQGAHEAIRPTDVNRTPETVAGFLTKEQLKLYTLIWKRFTACQMAPAVLDQTSVDIAAGDYVLRASGSIVEFPGFMTLYVEGRENGDEDSETEGLLPELKEGEVLRLEDLKADQHFTQPPPRYTEASLIKELEDLGIGRPSTYATILSTILDREYAVVRKKSLFPSELGWLIDGLMVENFPSVVDVDFTAKMEKSLDEIEQGQHPYRNLLAEFYEQFSKTLESARTNMVNLKAVGRRTDLQCPQCGLPLHIRWSRNGPFLACSGYPDCRFSSDYRRDEKGNIEPVAEESTGETCEKCGRPMILKKGRFGNFLACSGYPACKNTKAPGTGIPCPREGCSGELVERVSRGGRHFFGCSRYPECKTAFSGRPVPGKCPSCGTGPLIEKGGKGGSVKRVCVNPSCKYVETVPAAADRKAAKD
(61) DNA topoisomerase 1 [Lawsonia intracellularis PHE/MN1-00]
1
MGKNLIIVESPAKVKTIKKFLGSGYVVQSSVGHIRDLPKKNIGVDESKNFSPHYEIIPGKEKIVQGLRETAAKVDTVYLAPDPDREGEAIAWHVAELIKDKNSNIQRIQFNEITSKAVQEALSHPQKLNKNLFDAQQARRILDRLVGYKISPLLWKKVKQGISAGRVQSVALRLIVERDEERYTFIPEEYWLFKANLEGSNPPPFKVELWKVNNKKPIIPDAVTAAALEQQIKDKPFIVDSIEEKERQRSPKPPFITSTLQQAANQRLGYTAKRTMNIAQRLYEGLELGDKGTTALITYMRTDSVRIANEAKLAAATLIEQKFGKEYLAKGGNGRNFKGKAGIQDAHEAIRPIDVTILPEDVKPYLAPDQYQIYRLIWSRFIASQMSVAQFHDTIITINCENSQWRTKGERLLFPGFLAAFPNTKEEEDTNLPVLHKGEILKLHSLIKEQKFTQPPPQFTEASLVRELEELGIGRPSTYASIISTLQDRDYVRLEDKHFIATDLGRVVCMLLQDYFKNLMDVTFTAHMEELLDKVAEGKQDWVELLQNFSETFNPTLEEATKAMSQVKTGLETDINCPDCKKPLVIKFGKSGQFLACSGYPQCKFTSNYLRDDKGQIHLQEKVQPELQKIGICPKCNKDLVLKKARTGSRFIACSGYPECNYTEAFSTNVPCPCEGCKGMLVEKSSKKGKVFYACNTYPTCDYAIWNWPIQKSCPTCSFPILVEKITKAKGKHLACPEKNCRYTCELEESDIET
(409) DNA topoisomerase 1 [Sulfurovum sp. NBC37-1]
1
MKNLIIVESPAKARTITSFLGKDYKVIASKGHIRDLPKSTFGITIDDETGDLIPKYSIPRDANPTVKELKKLAKEAETIYIATDEDREGEAIGYHIAKAIGKEPTELPRIVFHEITKSAIQHALENPRKVDMDSVDAQQTRRLLDRIVGYKLSPLLASKIQKGLSAGRVQSSTLKIVVDREREIKAFKPEEYWTIDALFEKNIDASIYDYNGLKIDKLTIKTDADANEIVESAKGESFVVSSIEKTKRKTKTPPPFMTSTLQQAASTQLGFSPKKTMMVAQKLYEGVKTDKGTMGIITYMRTDSLNLAKEAVEAARTHIKETYGDKYLPAKAKHYTSKSKGAQEAHEAIRPTRVDFDGTKAANFLNADELKLYRLIYNRFLACQMTEAELESQTILFKGDKCTFKASGRKLLFDGFYRVTGYNEKDKLLPELKKEQPVSLDDIKAEQHFTEPPARYNEASLIKKLESLGIGRPSTYAPTITILQTRKYIEIEKKRIHPTEIAFTVIEMLEKHFPEIVDSGFTANMEETLDKVAEGETDWQTILKEFYTPFLQKIEEGKKNIKSLKVAIPTGENCPKCGSELLLRKGRYGEFIACSNFPKCKYTKNTDGTEVEQPEETDEKCEKCGSPMVIKNSKRGKFLACSAYPKCKNAKSLTPPKELSVPCPECGGKLQEREGRRGKFFGCENYPKCKFIANFEPVDKKCPECGYTMGKKTLRGKEIFECFKCKHKEEAK
(309) DNA topoisomerase 1 [Pelobacter propionicus DSM 2379]
1
MPQNLVIVESPAKAKTIEKFLGKDYKVLASFGHVRALPSKQGSVDIEQDFTPKYHILPESKKHIDAIKAALKDAKNLLLATDPDREGEAISWHLLAALGLDKKNPGKSIQRVVFHEITKDAIIHAVENPRDIATDLVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFKEQEYWTIAARLGVKPGAEFRASLVEVGGKKLGKFDIPDENVATALNRALKSGSYRVAKITRTERKRNPSPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGIDIGQEGTVGLITYMRTDSVTLSSQALTEAHEVISAAYGAEYALAKPRIFKTKTKNAQEAHEAVRPTSIARTPAELKKHLTPDLFKLYELIWKRTVASQMAEALLDQTSVDIAAELNEAVADCTVAESGAASPFTGAKRCGLRAAGTVIRFPGFMKLYIEGLDDQDEEKEGLLPPLQEGDDLKLHELFPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYTRLDKKRFFPEDVGMVVNDLLVAHFSRYVDYNFTAGLEEELDQVSRGEKQWKPLLKEFWEPFITLLKQKEGEVKKDDLTTTELDEVCPECGKPLAIKLGKRGKFIACTGFKEGCTYTRNLESDASEPSEPVLSDEKCDKCGQQMLIKDGRYGKYLACSGYPACKNIQPLVKPRGTGVVCPECKEGELTEKKSRFGKLFYSCNRYPQCKFALWDPPVEQPCPKCGFPLLVKKVYKRKGEFLKCPKEGCDYTSE
(426) DNA topoisomerase 1 [Desulfatibacillum alkenivorans AK-01]
1
MSKPLVIVESPTKVRTVKKYLGNDYNVAATVGHVRDLPQKNIGIDIDNNFEPQYEVIPGKQKVISNLKKLAKDASEIYLAPDPDREGEAIAWHTAQLLQGKNRRFHRVLFHELTKNAILNSMQNPLELDKSKFEAQQIRRILDRLVGYQVSPLLWKKVQRGLSAGRVQTVAVRMICEREREIQAFDPEEYWSITAHLQKDEPPVFPAKLLKIGDKKAKVSNEEEANAVLKELEGETYVVDRVIKKTVKRNPLPPFTTSKLQQDSIHKLRFSAKKTMLLAQQLYEGIDLGPGEPVGLITYMRTDSTRVSNEAALEALDYIGKVYGPEYRPDKPRFFQNKKKVQDAHEAIRPTNVLRTPNQVSDVLSKDQLALYTLIWQRFVASQMNPALFDQTSVSVKAGRYLFHATGSTLKFKGYLMVYDAGDGDKDDNKIMLPVLEEKMILQCNKLEPKQHFTQPPPRFSEASLVKELEENGIGRPSTYAAILSTIRDKGYVDLVKRYFRPSELGFIVNDLLVSSFGDIFEVPFTAQMEDNLDKVETSQANSLEILNAFYNSFKQDLENAGDKMVSVKGVGVPTGIKCPQCEKELHIKIGKNGPFLACSGYPECRFTRNYDRDDKGGIVMETPPETEETDEVCDKCGKPMLVKSGPYGTFLGCSGYPDCKNTKTMNGGAQQNQATGIKCPVEGCDGEIHERRSKRGKVFYGCSKYPKCDFATWDKPVDKPCPVCQSPYLVEKSTKKSGVYLKCPTRGCKYREDPQ
(497) DNA topoisomerase 1 [Geobacter bemidjiensis Bem]
1
MSQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPESKKHIDAIKKEMKGISSLLLATDPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITKDAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKLGGKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQLLPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFTQYVDYNFTANLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVNKSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEEICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFGKLFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS
(359) DNA topoisomerase 1 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]
1
MKKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKNPRKLNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDREKEIRAFVPLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSISDIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIAAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGRKILFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISILTSRDYVTIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIAEDKADWQETLKEFYYPFMRKIEEGKTKIASQKTVTKLGESCPDCGGELAIRKGRFGEFVACLNFPKCKYSRNLKSESKNESENTAAKAKANGTGITCPSCQKGEIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGETLVIKELKKGTFLECLKCKIKKEMKD
(123) DNA topoisomerase 1 [Campylobacter concisus 13826]
1
MKSLIIVESPAKAKTIKNFLDKSYNVIASKGHIRDLPKTSFGIKIEDDKFTPEYRISSDHSAIVKEIKELAKGADEIYLATDEDREGEAIAFHIANAIGKEPTSLPRIVFHEITKSAIQNALKSPRHVDMNSVNAQQTRRLLDRIVGYKLSPLLNLKIQKGLSAGRVQSAALKIIVDREREIQAFKPVEYYTIDTVFKKDLDAELVKFENQKIEKLTIQNPDRAKYIIENLQNEKFSVREIESKDRKIQPSPPFMTSTLQQSASNRLGFSPKKTMMIAQSLYEGVQTNEGFMGAITYMRTDSLNLAKEAVAAAREHILQNYGKEYLPAKAISYTTSSKGAQEAHEAIRPTNLNFTPQIAAKFLEKDALKLYTLIYNRFLACQMSACVSQTQNVYVASEKGEFKISGRKVLFDGFYKVYGELDKDKILPNLKKGDEMSLQSIKSTQNFTEPPARYSEAGLVKKLESLGIGRPSTYAPTISLLTSRDYVRIEKKQLIPNEIAFSMIGVLEEHFSNIVDSEFTSHLEEKLDEIALDKADWQKVLSDFYYPFMEKISAGKTGIKSLKTATPIGEKCPECGSELVLRKGRYGEFIACSNFPKCKYSRNVAKDNEKSAETGSTTAAKPKRELKKLDVPCPKCGGEIVERFSRRGKFYGCANYPKCDFISNYEPVAQKCDECGGDMIKKELKKGTFIECTKCKKKTLVSEN
(596) Reverse gyrase [Nautilia profundicola AmH]
6
MLHIIYKNECPRCGGDISSVNLNKGMFCDECMKSKKKEWNLENCENLLNYEKYCIADKKVNEFNEFFKFKCGNELNSIQKMWAKRFFLDNSFALLASTGIGKTTFGLLLSAFVKNSYILFPTKLLVAQAAEKYKKWGIEFVAYMGKKSEKELIEKGEYDILITTTQFLYKNRSLIKRNFELIFVDDVDSILKSGKKIADILTLLGIDKNSIEKTYELIKNQKYSEIKSVSKKGNLIVSSATANPKSKKILLFKYLLGFEVSRPNFNLRNIEDLYDENYSWDHSVKWINELGRGGLLFLPGNETKDTLYEYIDFLNTKNIKAYSYEDFEKHLEEFKEGKCFFVGFASYKNPLARGIDLPEYIKYTLFVGVPKIEFNLKDENFRAFYFIMLSLLPYLVKNNLSQKEVSEIQNDLNYLKKYIYLSKINVNTQQKIADILIRFKNTVKKYEDIIKTAENISFDGEKFIIADVTGYIQASGRSSRFYKGHLTKGLSLLLVDNKKAFYSLKKKLKWFGEIEFKNVEDVDIKKVLTEIEKSRTENVKTEFKTSFVIVESPTKAKTISSFFGNPSKRIINNVAVYEVLSQDRVLIIAASIGHDFDLVKDEGVWGVKDLIPIFHVLENKDKILQTLNINANEVEEVYAATDPDREGEKIAFDLTMINKPYNMNIKRIEFHEITKQAFEEALSIPREIDLNLVKSQLFRRITDRWVGFKISLYLQRLLNNTHLSAGRVQTPVLKWICERTGLLKEKIYVVIIRFNNVSIDFEFDTKQEANEFFNSLKESVYIKKLSSNTEVMFEKPFNTPDLLKEASNKLRFSPQKTMQLAQELFEKGFITYHRTDSYRISDTGKAIAKTYILENFSKDYLKFRNFESKGAHEAIRATTSMDADELRSYMLERNILLSEEHLRLYDLIFRKFIASQMKEAKVLKEKFLILLKEKSFITEIVENGYNLIYPINIYIISEGENKIVKELRQKPKAAPYTYAEVIEEMRSKGIGRPSTYAIIIEKLLKRKYITDKNGYLFATKLGFRIIKEVYKSDFKDFVSEEFTAELENIMDKIEEGKTEYEKELKKLFSLLF
(705) DNA topoisomerase 1 [Nautilia profundicola AmH]
1
MAKNLIIVESPAKARTIKNFLGKEYEVVASKGHIRDLPKTSFGIKIEEDKFIPQYRVTADHQPIAKELKEKAKKAETIYIATDEDREGEAIGYHIAHVIGKKPEELPRIVFHEITKTAIKKALENPRTIDLNRVNAQQARRLLDRIVGYKLSPLLNKKIQKGLSAGRVQSAALKLVVDREREIKAFKPQEYWSIEGIFKKIEGSLIKYNGKKLDKFDIKSKDEAQKIVEELKPLEYTVREIETKTTTVKSPAPFMTSTLQQVASSELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQQAALEFIKQNIGEEYAQAKTYATKNQNAQEAHEAIRPVDVRLTPDDLKNYLKPDELKLYALIFNRFLASQMKDAKFETQNIYIANDKGEFKISGRKLIFDGFYKVYGKPSANTLLPEFEKGEKLKPEDVKATQHFTKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEVKDKKLHPTEIAFSVIETLEKHFPDIVDANFTANMEEMLDEVAEAKKDWQEVLKDFYNPFMELVNKGYKEIPSQKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYPKCKYTRPLEESKEEKKTDVKCDKCGADMVVKKGKSGEFLACSNYPKCKNTKPLNAPEVLDDVKCPECGGDIVKRKSRRGEFYGCANYPKCNFISKYRPVNKKCPECGYLMAERTYRKKDVYECIKCKHREEAKK
(997) DNA topoisomerase 1 [Sulfuricurvum kujiense DSM 16994]
1
MKLIIVESPAKAKTIKNFLSKDYEVIASKGHIRDLPKNRFGIKIDDEKIIAEYRISEDSTATVKQIQELAKKSDTIYIATDEDREGEAIGWHIAHAIDKDPSSLPRIVFHEITKNAIIHALETPRTIDMDRVNAQQARRLLDRIVGYKLSPLLANKIQKGLSAGRVQSSTLKIVVDREREIRAFIPEEYWTIDTLFKKDIEAALVNFENEKIDKLTIKTGDEAARIVETLKGESFKVGEIETKERKSSTPPPFMTSTLQQTASSQLGFSPKKTMMVAQALYEGVKTPEGTSGVITYMRTDSLNLATEAVEAAREVILTRYGKEYLPKEAKVYTKKSKGAQEAHEAIRPTMLGFTPEVAATYLKPDEIKLYRLIYNRFLACQMNDARFEQQSITFESAKAQFRATGRKLLFDGFYRVTGSDDKDKLLPSLTTGDSIEIQTVTPEQHFTEPPARYSEASLIKKLESEGIGRPSTYAPTISTLQARNYIEIEKRAIMPTEIAFTVTEMLENHFNEIVDASFTATMEETLDEISESGKSWHKILLDFYYPFIEKIDAGKSNIVSLKMAKPLGRNCPQCGSELLLRSGRFGEFIACSGFPKCKYTEQTEENQKENPATPDEVSEEVCDKCGSAMVVKNGRNGKFLACSGYPKCKNTKTLNQETKFSQVPCPECGGKLLWRQSRRGAFWGCEHYPKCKFISKFEPSDKKCEVPGCGGALAPRTYRNKEVYECVKCKDRTPREEAGE
(572) DNA topoisomerase 1 [Arcobacter sp. L]
1
MASMGHVRDLPKSSLGFDPSDNFKPKYMVTADKKKVISDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAILKALENPRDVDQHLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFVPEEYWKVKADFINPELKAELAKISAKTAKVDNEEQALNIESSLNQGIYKLASIEEKESIRNPAAPFTTSTLQQEASRKLGLSVKQTMVIAQQLYEGNVGNIPNHTGGLITYMRTDSLNLSTVATSAAKAVIEEEYGKEYSLSKPRVYKSTAKGAQEAHEAIRPVNLALKPSMIKEFVEPAQYKLYSLIWKRTLATQMAQAKIANTTYKIEAGRDKEFEFQSKGQRIIFAGFMKAYTEGSDNPEAALDSTEKILPNIKVGTVLELEKLESEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYVTKTEDKKLIPTQTGEIVNSFLVDHFSDIVDLGFTAKIEEEFDEIALGKIAWEQVMKDFYGNFKKTIDEKEESVHKEDYLQSREIGIDPKSGKPVSARVGRFGPFIQIGTKDDEEKPKFVAIPDNLNMDTITLDEALFLFTLPRVVGLDNSGDEIKANIGRFGPYLQVKTKFYSLKTDDPYTVDLNRALEIIKETDEAKEKSTIKTFDKEKIQILIGQYGPYIKQGRKNFKIPKSVEAKDLTLEQCLEIIAKDSKTKTSSTKKASTEKKASTEKKETKKKTTTAKKTTKKSADK
(1699) DNA topoisomerase 1 [Sulfurimonas autotrophica DSM 16294]
1
MNLIIVESPAKAKTIKNFLGKDYDVIASKGHIRDLPKSRFGITLDEETHELVPKYSVAKENAPTVKEIKEKAKKADTIYIATDEDREGEAIGWHIAHAIKKDPLELPRIVFHEITKTAIKHALESARKIDMDMVNAQQARRLLDRIVGYKLSPLLASKIQKGLSGGRVQSSTLKLVVDREREIKAFVPQEYWSIDTVFKTNIDANLIKHKDKKLSKLSIENKEQAETITQSVKNDNFTIAKIETKQRKSSTPPPFMTSTLQQTASSKLGFTPKKTMMIAQTLYEGVKTPDGTSGVITYMRTDSLNLAQEAVGAVRGIIENRYGKKYLPKEPKIYTKKAKGAQEAHEAIRPTMLQFTPEVAQSFLKADEIKLYRLIYERFMACQMEDAIFEQQSIIFKGNENEFRASGRKLIFDGFYAVTGTEDKDKLLPTLKEGEKAEIQSVKPEQHFTEPPSRYSEASLIKKLEAEGVGRPSTYAPTIATLSNRTYVTIEKKQIIPTEIAFTVTEILEKNFPNIVDINFTAEMEEELDEIAEGKVDWQKLLLEFYEKFMKQIEEGKENIVSLKLAKPLGRTCPKCGEHELLLRSGRFGNFIACSGFPKCKYTEQCDEEGNAVEKKETTADEKCDKCGADMIVKNGRNGEFLACSNYPECKNTKSINVEEKVSETPCPDCGGKISLKNSRRGPFWGCENYPDCKFISKFEPTTIKCKEEGCSGVLAPRTYRNKEVYECVKCKARTPKEEIDTKK
(375) DNA topoisomerase 1 [Arcobacter butzleri RM4018]
1
MASMGHVRDLPKSSLGFDPNDNFKPKYQISTDKKKVITDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAILKALENPRDVDQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFVPEEYWKIKADFINPELKAELAKENGKTLKISNEKQALEIEASLKQGSYKLVDIEEKESTRNPAAPFTTSTLQQEASRKLGFSVKQTMIIAQQLYEGNVGNIPNHTGGLITYMRTDSLNLSTVATTAAKAVIEEEYGKEYALNKPRVYTTKSKGAQEAHEAIRPVNLALRPSQIKEFVEPAQYRLYSLIWKRTLATQMAQAKIANTTYKIEAGKNKEFEFQVKGQRIIFAGFMKAYTEGSDNPEAALDSSEKILPNIKEGTILELEKLESEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYVSKTEDNKLIPTQTGEIVNSFLVDHFSNIVDLGFTAKIEEEFDEIAEGKIAWEEVMKNFYGGFKKTIDEKESSVSKEDYLQVNELGIDPKSGKPVSARVGRFGPFVQIGTKDDEEKPKFVAIPDNLNMDTITLEEALFLFNLPRVVGNTENGDEIKANIGRFGPYLQVKTKFYSLKTDDPYTIDLNRALEIIKDIDEAKEKSTIKTFDKEKIQILVGQYGPYIKQGRKNFKIPKGKNAEDLTLEECLEIIEKDSKGSTKRTTTKKSATEKKTTAKKTTKKSTDKK
(527) DNA topoisomerase 1 [Hippea maritima DSM 10411]
1
MNLVVVESPAKAKTISKFLGKNYSVVASYGHIRDLPKSSFGVDIEDGFKPKYVIPKDKQPIVRELKKLTKDSDLVYIATDEDREGEAIGWHITQATKLDETKLKRIAFHEITKKAILDAIKSPRSIDMDMVNSQEARRILDRIVGYKLSPLLAKKIRKGLSAGRVQSVALKLIVDREEEIQSFKPEEYWTIHLIFENSIQADLTKAYGEKFDKLFIKKEDDKARVSKLKEEIEKESFNVYSITKTKSLRKPEPPFITSTMQMAASTYLGFSAQRTMRIAQSLYEGVDIGKERIGLITYMRTDSVNIAKEALTKVRRTIKELLGDEYLPSKPVTYKTKSKLAQEAHEAIRPTDPALLPDMVKPYLTEDQFKLYDLIWRRFVASQMKPAEFRNTKITFTSYNFEAKASYKELVFDGFLRIWTFSKLNEDKIPILKKNQSVELTEVKPKQHFTEPPPRYTEASLIKELEKHGIGRPSTYATIIDTIIKRGYVVLKDKRFYPEEIGIITSRMLDKFFSDIINVKFTAQMEDGLDKIANRELTKLELLKRFYDKFKVLLENAYENMERIKPEDEPTDEVCPLCGANLVIRHGRFGKFLACSNYPKCKYTKPLQEEITEIKCDKCGAPMVVKYSRKGSKFLACSNYPKCKNTKPYPTGLKCSECGGDLIEYSSKRGRFYGCSNYPECKFTIKGELKNQKCPKCGYSLFVKKKDKWCCANKKCNYCE
(1171) DNA topoisomerase 1 [Geobacter lovleyi SZ]
1
MAHQLVIVESPAKAKTIEKFLGSEYRVLASFGHVRALPSKQGSVDTANDFEPKYHVLPESKKHIDAIKKELKGADRLLLATDPDREGEAISWHLLAALGLDKKPKIPIQRVVFHEITKDAIIHAVQHPRDIAIDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFVDQEYWTIGAKLEKQGGQTLKAGLVAVDGKKLGKFDIPDQKSADALKNAIAQGKAEVASVTRKEMKRNPAPPFTTSTLQQEASRKLGFSAKKTMSTAQKLYEGVAIGEGGTVGLITYMRTDSVNLSAQALKDAHDLISVAYGKEYALAKPRFYKNKSKNAQEAHEAIRPTYLDKTPAELKKYLTPDLFKLYELIWKRTVACQMAEALLDQTSVDIAVSGQKTDSFILRATGSVIRFPGFMKLYIEGVDDEDEEKEGTLPALDEGEALKLLEVLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASTLNTLVERKYARLDKKRFFPEDVGMVVNDLLTAHFPKYVDYNFTAGLEEELDQVSRGEKQWKPLLREFWNPFISLLKQKEGEVKKDDLTTETLEEACPECGKPLAIKLGKRGKFIACTGFKEGCKYTRNLENSGTEEAAEPEVSEEKCDKCGQPMLIKSGRYGKYLACSGYPACKNIQPLNKPKGTGVTCPECKEGELTEKKSRYGKMFYSCNRYPDCKFALWDPPVTQPCPKCGFPVLVKKVYKKKGEFLKCPKEGCDYTSA
(1827) DNA topoisomerase 1 [Helicobacter felis ATCC 49179]
1
MGKNTKLIIVESPTKAKTIAHFLDNSYEVIASKGHVRDLSKYAMGIKVQDNKFIPKYAIDKDHEEIVAQILQKAKNAQEIYIATDEDREGEAIGYHIAYLIDQAGNRSKDPLIEMRALEEQSQTKNPHPIFAFPRIVFHEITKTAILHALKHPKTLDVHKINAQLARRLLDRIVGFSLSSLLASKISKGMSAGRVQSAALKLVVDREREIKVFKPIIYYEITGTIAQASVSLQSYRHEKIKKQGLRDSKEALEMVANLSAQTYQVQEISTKEKNTPSPPPFMTSTLQQSASNQLGYSPSKTMSIAQKLYEGVMTSEGVSGVITYMRTDSLNIAKEAIESARVFIEQTYGAPYVPKKPKVYTSKNKSAQEAHEAIRPTNLAFTPAIAKDYLKPEEHKVYTLIYQRFLASQMSDARLESQSVSFACESLGAVFKASGHKLLFEGFYKVLGNGDKDTLLPSFTLHQEVRLEKLEAKECSTQPPARYSEASLIKTLESLGIGRPSTYAPTIALLLSRDYVSLQQKQLTPTPNAFSVIEILEKHFSEIVNATFSAGLEDKLDAIASHELNWQDMLLKFYTPFMAQIEEGKIQIASQKVSAPTGESCPKCGAPLVQRTGRYGVFVACSAYPKCKFIKSEVVQTEDLGVCEKCGAPMVSKRGRFGTFVACSAYPTCKNIRNEESKNTPALAKCPQCGGDVRAKRGKRGMFYGCDNYPSCKFISNYKPAPKPCPECGGLCVMKIYKTKPSVQECLQCHIQVEIEGEQV
(880) DNA topoisomerase 1 [Helicobacter pylori F32]
1
MKHLIIVESPAKAKTIKNFLDKNYEVIASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKELVKQIIELSKKASTTYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILNALKTPRKIDMSKVNAQQARRFLDRIVGFKLSSLIASKITKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDAYFESHLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYTISGIIKKSKKSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARNKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSIVLEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQSVVVACEKGEFKASGRKLLFDGYYKILGNDDKDKLLPNLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVMEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYVKQTENANDGAKQELCEKCGGEMVQKFSKNGAFLACNNYPECKNTKSLKNTPNANEIIEGVKCPECGGDIALKKSKKGSFYGCNNYPKCRFLSNHKPINKRCEKCHYLMSERIYRKKKAHECIQCKERVFLEEDDG
(764) Topoisomerase I [Helicobacter pylori F32]
3
MKDSVIIIESPNKVAKVKEITGAKVFATIGHFMQLKSYDENNNFKPTFEYDSQKKKRIFEIIEACKNKKVYIATDPDREGYAIGYHFYEKIKKIASSIYRAEFFEITPSGINKGLQNALLFENTNKQMYQSALARRVADMLLGFTLSPYLGKALGQMKGSSAGRVQTPCLKLIVDRDREIEKFKALPENEKVSYQIQAKINDNANREVIIKHCDEKGEEIKFNDKEEALKLFESLKDNKACLLKDLKISVVETKPKKPFITSTLLERASSELGLGIAEVQSLAQSLFEAGLITYIRTDAESLSVEFLNEAESFYLPIYKEVYQKREYKAGKQSQAEAHEAIRITHPHKYEDLESIVYNAGITNQDALKLYRLIFERTIESQGKNAIYDKQDLLFKIKNEYFKCSAKSLKSTGFLAMFSKKELENDDESNDDKEDKEKEQNAQFNLKIDDMLSLNDLVLATIKRNAPSPYKEASFVKLLENKGIGRPSTYASYLSTLLKREYISISQDKKHTITPTHKGKRVIEVFENAYQFIIDLTYTKQMEEVLDEIVENKSSYLDFLQNLATKCPKIEKLERNDDEIKPSSEGQITYIENILRDLQLDLSEEFKNYKEDNRIAKAFLDRYIKEHEFFEKNNKKASSSNNNEIRPATPKQINFAEILAKKHNVKLPKDYKSNIKVCGDFINEYHKK
(1497) DNA topoisomerase 1 [Helicobacter hepaticus ATCC 51449]
1
MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDHMEIVEKIKVASKKAKVTYIATDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITHSLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQRGLSAGRVQSSALKIIVDREREIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAMLEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVETNFGSMGVITYMRTDSLNIAKEAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAIRPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDALFEIQNIIFTPHNQTHLIEFKASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSMESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGLEDKLDEIAQAKMNWESVLWEFYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRKSKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGEPMIKKFGRNGEFIACSGYPKCKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKCPQCGGISVEREYRKKQVRECLKCKHRIEI
(525) DNA topoisomerase 1 [Helicobacter canadensis MIT 98-5491]
1
MSLKDLIIVESPTKAKTIKNFVGSNYEVIASKGHIRDLPKHSFGIKIDNQEFIPEYKIDESHKNIVSELKKLAKDSKTIYIATDEDREGEAIGFHIATAIGKDPQKLPRIVFHEITKKAILDSLKNPRHIDMDKVNAQQARRLLDRIVGYRLSPLIASKIQRGLSAGRVQSSALKIIVDREKEILNFKPITYYSIDIAFKEQLESELLEFKGKKIQKLSLQDKAEALEMIQQLKQESFKVKEIENKKRKTATPPPFMTSTLQQSASSILGFSPSRTMQTAQKLYEGVMTHKGSMGVITYMRTDSLNIAKIAQDEAREFITKTYGKEYAPSKPKNYATKAKGAQEAHEAIRPTLVDFTPQIAAQYLKGDELKLYTLIYNRFLASQMSDAEFELQNIFIDSNSSLLKISGRKLIFDGFYRILGNEDKDKLLPHLKVGEVLKLEKCDLSEHQTEPPARFSEASLIKTLESLGIGRPSTYAPTISLLNSREYISIEKKQIKPQEIAFKVVELLEKHFLEIVDSKFTANLEEKLDEIAENKQDWQKLLWEFYEPFIQKVNEGKTSIQSQKIALPTGENCPLCGKELIKRSGRFGEFVGCSGYPKCKYIKKEVEENAQEESYGVCEKCGKPMVKKRSRSGEFLACSGYPECKNTKSLNNSAPSAKKAVEGVKCPKCSGEILERMSRRGKFYGCANYPKCDFISTYEPTNVHCPKCNSLMAKRTYRKKAVLECIACKERIEEIQTTIKE
(640) DNA topoisomerase 1 [Campylobacter fetus subsp. fetus 82-40]
1
MSKLIIVESPAKAKTIKNFLGSEYKVIASKGHIRDLPKSSFGIKIEDDKFTPEYRVSSDHSAIVKEIKDLAKNADTIYLATDEDREGEAIAYHIAAAIGKKPEMLPRIVFHEITKSAIQNALENPRSLNMDSVNAQQARRLLDRIVGYKLSPLLNSKIQRGLSAGRVQSSALKILVDREREIRNFKPIEYFSIDTKFKKDLEAELVEFEGSKIEKLTITNKDRAKFIVDKIKDESFSVANVESKERKTSPQPPFMTSTLQQSASNRLGFSPKKTMMLAQNLYEGVQTNNGFMGAITYMRTDSLNLAKEAISAARDLIKEQFGDKYLPKSANFYTTKNKGAQEAHEAIRPTNLSFTPTEAAKFLEKDLLKLYTLIYNRFLACQMSASVSETQNIFINSKSSIFKISGRKLTFDGFYRVYGDLDKDRILPNLNVGDKMELESLSSQSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISLLTSRDYVKVDKKQLIPNEIAFNITSMLEEHFNDIVDSDFTSKMEEKLDDIAENKADWQEVLSKFYHPFMQKIDDGKKNIKSQKVTEPIGEKCPECGGELVKRKGRFGEFIACLNFPKCKYSRNLKNEAKIEKKEPQKIGVACPQCGGDIVERFSKKGKFFGCANYPKCNFISKYQPTDQKCPQCGEMMVYKELKKGNFYECSACKFKKEGNNNE
(1703) DNA topoisomerase 1 [Nitratiruptor sp. SB155-2]
1
MGKNLIIVESPAKARTIKNFLGKEYEVIASKGHIRDLPKSSFGIKIEEDKFIPQYRVDKEHSQITKQLKELAKKADTVYIATDEDREGEAIGYHIAEAIGKKPQELPRIVFHEITKSAIQKALQNPRTIDMNRVNAQQTRRLLDRIVGYKLSPLLSSKIQRGLSAGRVQSAALKLVVDKEREIQAFKPQEYWSIDAIFNDTIEAALYEYMNKKIGKMDIKNEKEAQAIVDQVKNESFVVAKIEKKKRITKSPAPFMTSTLQQTASSKLGFSPKKTMMIAQKLYEGVQTPKGITGVITYMRTDSLNIAKEAQEAARDLIKKQFGEKYLPKKPKEYATKSKGAQEAHEAIRPTMLDFTPEVAKNYLSADELKLYTLIYNRFLASQMEDAVFETQTIYFKSPSATFKASGRKLIFDGFYKVLGNEDKDKLLPDLKEGEEAKLTKIEANQHFTEPPARYTEASLIKMLESLGIGRPSTYAPTIALLQARNYIELEKRAIKPTEIAFKVIEVLEKHFPEIVDSSFTAKMEEELDEIAEAKKDWQKVLKAFYDPFIELIEKGKKEIKSQKVAIPVGRNCPECGAELVKRKGRFGEFIACSAFPKCKYTEQIESEEKGPQESNEVCEKCGSPMVVKQGPRGSFLACSAYPKCKNTKPLAKNEPKKLDVKCPECGGEIVERFSRRGKFYGCSNYPKCTFVSKFEPVDKQCSECGYMMAKRTYRNKEVYECIKCKHREEVQ
(69) Reverse gyrase [Nitratiruptor sp. SB155-2]
6
MIDLVYKGLCPNCGGDICSDRLDKGLLCKRCMPKEGEPCEVLKEGEFVKVCEVEQRSVEFEAFFKEKNGFLLRQIQKSWAKRFFLGHSFALLAPTGVGKTTFGLSLASFLDQKSYLLFPTQLLVNQAVEKLRLLGIEPLFYDSGFSKSKKDEVKAKIASGDFEILVTTTAFFYKNFDSIPKAFGFVFIDDVDSILKSARNIDKVMLLLGFSQEDIDAAMQFIDHKIKGDLSYEEFEQWQAKIEAIRSHAKAQLIVSSATANPRSRRVGLFRELLGFEVSRPSITVRNVEDLYEKPEKLWERSVELVERLGRGGLLFLPGNETKERLQEFLAFLEQKGVKAQSYEDFDAKAFEEGEVEVLVGFASYRNPLARGIDMPATIRYALFVGVPKLEFTLDITKHTSLYFFLLALLPVIRNHPNFHQFMQYVNYLKRLVRVPTERLNEKAKARVQTIYHDILAILDEELIDAINKTPDVSLVKEDEYFKIITADVTGYIQASGRTSRLYVGGLSKGLSYLLVDSEKTFSSLQKKVRWFSEEIVFKSAKEADIDAILKIIDEDRKKIALALQGKFQEAKEFFTTSLVIVESPNKARTIANFYGKPMVRDLGGIRVYEVAKEGKILSITASKGHVVDLQKQEGVYGVLRQEHFIPLFEPIDENKRRIIEALRRIGVEVQDVYIATDPDVEGEKISYDLQLLTKPYNHTVQRAEFHEVTKRAFDEALSHPRDFDENLVKAQLVRRIADRWIGFSLSQMLQKKLQKSWLSAGRVQSAVLEWIVLREKEAKEKIFVVHVSFRGLEAEFVFDEKQKAKDFYERLEVVEVRFIQKETKELFRTPFTTDAMLYAASSELHFSPQKTMQLAQDLFESGFITYHRTDSTRISSVGIAIAKEYIQSRFGQDYFVPRSHSKAGGAHEAIRPTKAMDAQELEQFLQMQNSNLTQDHLKLYDLIFKNFIASQMKSAKIEEIAAQVEAFDQKTTIRFYDEIVEHGIDLILPVQLHQLQEGRYAVQKELLTRSKVPKYSYADVIRLMKERGIGRPSTYAITIQKLQERHYIVQRRGILYPTKLGQEVYEELRKNPEVYTFVNEHYTKELEALMDRVEKGEVSYEEVVESLYLQLKERIEF
(279) DNA topoisomerase 1 [Pelobacter carbinolicus DSM 2380]
1
MAQSLVIVESPAKAKTIEKFLGPGYKVLASYGHVRALPSKQGSVDVEHNFSPLYHVLPESQKHIELLKKEAKKSRELILATDPDREGEAIAWHLLEALGIDENAKSPEVKRVTFHEITKGAIQEAISKPGHIARELVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPARLYAVDGNSLGKFDINQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQEASRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVALSQVATGEARELITRMYGEDYALDKPRVFKNKAKNAQEAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLIWQRTVASQMATAQLEATTVDIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQEEGTLPPLEQEQPLDCQEVQPSQHFTQPPPRFTEASLVKTLEEHGIGRPSTYASIINTLTTRKYVRLEKRAFYTEDVGMVVNDLLVNHFNKYVDYDFTAQLEEDLDAISRGEREWQPVLKDFWEPFISRLKEKETQISKQDVTTEKTDRICPECGKPLVIKLGRSGRFLACSGFPDCRYTEPLAGQEREEPVMSDQTCEKCGAPMLIKQGRYGKFLACSAYPECKNIQPLVKPKALGITCPQCGEGELMEKKSRYGKIFYSCNRYPKCKYALWDLPIEEPCPKCKFPLVVEKTTKRQGTFRKCPQEDCDWTVVLIPPEPKAATKKTTTQKTAAKKTPAKKTAAKKTTAAKPAEKKTASKKSAAAKPAAKKTAAKKTTTTKAATQKAAPKKTAAKKATKKEE
(751) DNA topoisomerase 1 [Helicobacter acinonychis str. Sheeba]
1
MKHLIIVESPAKAKTIKNFLDKNYEVIASKGHVRDLSKFALGIKIDETGFTPNYVVDKDHKDLVKQIIELSKKASTTYIATDEDREGEAIGYHVACLIGGKLESYPRIIFHEITQNAILNALKTPRQIDMSKVNAQQARRFLDRIVGFKLSSLISSKVTKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDALFEPNLEAQLVSYKGNKIKAQELIDGKKAQEIKNELEKESYIISSIVKKSKKSPTPPPFMTSTLQQSASNLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARDKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSVILEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQNVVVACEKGEFKASGRKLLFDGYYKILGNDDKDKLLPNLKENDPIKLEELESNTHVTEPPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQIRALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEKTGESCPKCGGELVKKNSRYGEFIACNNYPKCKYVKQVENAHNEAKQELCEKCGGEMVQKFSRNGVFLACNNYPECKNTKSLKNTPNAKEMIESVKCPECGGDIALKRSRKGSFYGCNNYPKCNFLSNHKPIDKRCEKCHYLMSERIYRKKKVHECIKCKERVFLEEDNG
(1712) DNA topoisomerase [Desulfotalea psychrophila LSv54]
7
MTTKILIIAEKPSVAGDLAKVLPGKFTKQKTHYESDSHIVSYAVGHLVSLCYPEEIDPIYQKWGLANLPILPESFPLKAVENTKSQLNALKKLIRRKDVTEIINACDAGREGELIFKYILKYVWNTSVAKKTIKRLWLQSMTAESIKKGFNNLRENDTMQSLEDAALCRSESDWLIGLNATRALTGFNSRKGGFFLTPCGRVQTPTLSLIVKREAIRNGFTPTDYNCLQANFSFETGSYSGKWIDPNFKKDPKNSYLRQDRIWDKQKALAILEKCQQKPANATENSKESRQSAPQLFDLTALQREANSRFGFSAKNTLGIAQALYEKHKALTYPRTDSRHLPEDYVDTVKEITQNQTGWEFAAIAKTALKEGYIKAQTRIFNNKKISDHHAIIPTNTLPQNLSEPELKIYTMVVQRFLAIFFPPAVFHNTKRYSLVEGQTFLTEGKILLEAGWKVVYAGADGSTGKDKILAPIPTGSPVTCNKIEKEALTTTPPARYNEATLLSAMENSDKFIENEELADAMKERGLGTPATRATIIEKLIKEKYVVREAKDLVPTGKAFELFSLIEAMKIDTLASPEMTGEWEYKLNQIFKGEMTRDDFMQEIRQLTQQIVDRVRDFNTDEERSLAPFSPVGETVIYSTPTAWVSEDGTIAIRKVLGGRLMSNKEIVALLEGKSLGPFSDWRSKRGKNFTATVSLKNNKIEFIFADSTADLDIDSIKKQEPLGLSPVDQTAVFETPVGYMSESALDGESKKGLKISKVILDKTISKENIQQLLTDGKTELIQGFISKRKRPFDAYLLMDKKGKITFEFPPRKPKNKPQD
(1373) DNA topoisomerase 1 [Syntrophus aciditrophicus SB]
1
MPDSLIIVESPTKVKTLKKYLGADYEVLASKGHIKDLPKKTLGIDPQNEFQPTYSVIDDKKKVIADLKKAAKNVSRIFLAPDPDREGEAIAWHIAEEIKAKNKEIYRVLFNDLTKNTILDAINHPGKLDFNKYEAQQTRRILDRLVGYQISPILWEKVKRGLSAGRVQSVAVRMICDREEEIKRFIPEEYWNISVQLKGVTPPPFEARLIKITGKKAKVKNEAQANEIVSRLSGGVKSGSKPTINLSEDRDLQPQFVVSKLEKKEVKKESLPPFTTSKLQQEASRLLRFSAKKTMATAQKLYEGIELGEEGPVGLITYMRTDSVRIAEDALKEVRSYIRENYDPPFLPAKARFFKSKGKTQDAHEAIRPSSMNYNPQKIKHFLSADQFRLYQLIWNRFVASQMNPALYDQTTVEVSADFYTFRAQGAILKFPGYTIVYTEGKEDKEQNEEMESGKILPDLNEGERLTLLKITPEQKFTQPPPRFSEASLVRELEEQGIGRPSTYAAILSTIQDRNYARLEQGKFHPTELGTIVTELLVKNFPKVMDVSFTASLENQLDLIEEGKQKRIETLQEFYAPFEEDLSKARLEMKNIKREETPTDLICEKCQSPMVIKWGKNGKFIACSNYPACKNTRNIEQGEGVERSAKGGEMTDTVCPKCGKNMLIKHGRFGRFLGCSGYPDCKHTMPISLGVKCPQEGCDGEIIEKRTKKGRSFFGCSNYPNCTFAVWDKPIPEPCPQCNSPFLVEKYSRTEGSYKACPNKDCGYRDDQS
(368) DNA topoisomerase 1 [Desulfohalobium retbaense DSM 5692]
1
MSTDLIIVESPAKVKTIRKFLGSDYLVEASVGHVRDLPSSNLGVDEDNNFQPQYQIISGKQKVVSRLKSAAKKATTVYLAPDPDREGEAIAWHVAELLKKTNTNLKRIQFNEITSRAVKDALEHPRDLDERLFYSQQARRILDRLVGYKISPLLWKKVKRGLSAGRVQSVALRLIAERERERQQFDPQEYWVLKAHVQAAAPPPVVAELWKIGGKKPHVANETQALEIEKKVSEAGFHVESVEEKERKRHPKPPFITSTLQQDASNRLGFAAKRTMRIAQQLYEGLDLGDKGTTALITYMRTDSVRISNEARNAAQKWIVSTLGEAYYPEKPRYFKTKGSAQDAHEAIRPVDPTLTPGSIQSYLSREHFRLYKLIWERFMASQMAPARFWDTQLTLASANTLWRAKGERLIFDGYLRVYSADKSQEEVELPKVQAKDALTLEKIDKEQKFTQPPARFSEASLVRKLEELGIGRPSTYAQIISTLLDRNYVQLAKKQFVPTEMGFVVADLLTAHFPQLLDVGFTAEMEKKLDSVAEGDQDWTQLLREFTESFYPTLEKAEQEMQQVKTGVETGVSCPKCGKPVVIKFGRNGEFLACTAYPDCDFTSNFTRDEAGTIVIVEPEPQERQKVGTCPECGQDLVLKKARTGSRFIACTGYPKCKYTQSYSTGVKCPKQDCPGELVEKSSKRGKVFYACNQYPDCKTAYWNWPIAEECPTCGSPILVRKETKARGEHVACPEKGCGYWRELRDDEKH
(1600) DNA topoisomerase 1 [Desulfovibrio aespoeensis Aspo-2]
1
MPKDLIIVESPAKVKTISKFLGKDYMVDASVGHVRDLPTRDLGVDEENGFTPRYEIIQGKEEVVKRLKAAAKKAGTVYLAPDPDREGEAIAWHVAELLRPVNSNIRRIQFNEITARAVKEALENAQDLNQNLFDSQQARRILDRLVGYKISPILWKNVKRGISAGRVQSVALKLLVEREKERRAFKTDEYWPFKVLLEGGNPPPFWLELHKLSGKAVKPGVNHISTQAEAEALQQTLEAGQFTVDSVQEKQRKRDPLPPYITSTLQQDANRRMGYSAKRTMSVAQRLYEGVELGRHGTTALITYMRTDSVRIAKEAQEAARELIIDRFGADYYPSKPRNFKTKGGAQDAHEAIRPVDVTITPDDVKSSLPSEQHKLYRLIWQRFVASQMAAASFWDTTVLVSAPATEWRAKGERLLFPGFLAAMDKSGTEAETELPKLVEGETLRLNELKKEQKFTQPPPRYSEASLVKTLEELGIGRPSTYAAIISTLLDREYARQEEKRFVPTELGFTVSDQLSEHFHALMDVGFTAQMESLLDDVAAGKQDWAKLLKDFGHDFYPTLEKARTEMARSQQETDIVCENCGKPMSIKFGKTGEFLGCTGFPTCRTIKNFTRDENGAIRIVERETPEETGVECEKCGKPMAIKQSRRGEFLGCTGYPDCKNIVNFQRDENGAISVIESEKLQVVGSCPDCGGELLLKKARTGSRFIACSNYPDCTYAAPFSTGVPCPVEGCAGELVEKSSRRGKIFFSCSAYPKCDYAVWNWPVNEPCPKCGHPILTRKTTKDKGEHLACPQKGCGYTREPDEPADTPDTPDLPDMPDDNA
(852) DNA topoisomerase 1 [Desulfovibrio vulgaris DP4]
1
MGKDLIIVESPAKVKTIKKFLGGKYVVQASVGHVRDLPTNEIGVDEANNFAPQYRVIDGKQKVVDTLREAAAKADTVYLAPDPDREGEAIAWHVAALIEGKADNIKRIQFNEITARAVREALENPRDLNRALFDAQQARRVLDRLVGYKLSPLLWKKVKRGISAGRVQSVALRLIVDRESERRAFTPEEYWLFRAMFAKNVPGATPTSPDPQYAPFKAELAKIDGKKAHVADADAANALEDAMRGKPFVITAVERKKRERQPQPPFITSTLQQAANQRLGYSAKRTMNIAQRLYEGVELGEMGTVALITYMRTDSVRVSDEARDAARAFVTETWGADFCPAKPRQFKTKGSAQDAHEAVRPVDVNVTPDSVKHLLPPDQFQLYRLVWSRFVASQMAPARFDDTTVAIACGPAEWRAKGERMLFPGFLAAMPQKEEGDAELPPLQEGETLHPVSVEKEQKFTQPPARYTEASLVRELEERGIGRPSTYASIISTLIDRDYTRLEDKHFVPTDLGATVCDLLARHFTTLMDVGFTAQMEDSLDKVAEGGLDWVELLSRFSADFNPTLESAAKAMETVKGGLPTNVTCPECGKPVVVKFGKAGPFLACTAYPDCKFTSNFSRDEKGDIVIEQRAREELEAVGTCPECGKDLVVKKARTGSRFIACTGYPDCRHTEPFSTGIACPREGCDGQLVEKSSKRGKIFYSCNRFPKCDYALWDWPVPGPCPVCGSPLLVKKSTRAKGLHIACPEKTCRYTQELPDDEG
(749) DNA topoisomerase [Desulfovibrio vulgaris DP4]
7
MSKTLIIAEKPSVAREIAPLVGAQGRRAGYLEGPDHLVSWAVGHLVGIAEPEEQDEAWAGRWTLEQLPMLPPRFQLRVLPETADQFAVLQRLLLDDRVTGIVNATDAGREGELIFRRIYLVAGCDKPVRRLWASDMTEEGLRKSLARLLPDEEKRNLGLAAFARAEADWLVGMNFSRLFTVKSGGLVSVGRVQTPVLCLLADRRRDIEHFTPQDFWTVEATFDKNLDAGTSTGTRPMTSPAARSTVPCLAESGPATGDAPPAPDGDRTTQSEAQTDEGTKPDAQADALSDASSAAPATSAPDTPVASDVPDAEIAAPEAAANDDRFRGVWHRPPDRRETRVDSGEEADAIATACTGKLGIVESVQGRAGTQQPPLPFDLTTLQREANTRFGYSAKDTLTHAQSLYETRKLITYPRTDSRHLTKELFGEILNHLRAVHHLYPEETMLAVGRIKSGKARFACVDDRKVTDHHAIIPTARKGNLTQLSAPERNIYDMVCRRTIAAFCPEAKFSTSTVTVMVGEHPFIAKGKVFKDKGWMVVEPWRTAEDTPLPQLRKGSKLLTLDVGPVKRQTKAPAHFTDASLLAAMETAGRLVEDDALRQAMKERGLGTPATRAQVIETLVARGYVAKQGKKLVATDRGMQVAETVTTLLPDVASPELTGQWEKRLKDIEAGVDSYPAFMRSIRESVWHGVHRIRNRDIRPLLRDIAARNSRPPDGRCPLCGGDVVETPRGFACKGDSKGKTEGDSTAARCPFIIWKEMHGKAMDEDIVRELLAKGRTAEAFDLTSRQGKSFRAHLVLEGGRVGLDFVRDRTPFRRDEDPQRTVHATGARPAAVPDVDTTSDAHPGADDASAPLTESSHAEGG
(1668) DNA topoisomerase 1 [Helicobacter bizzozeronii CIII-1]
1
MKANPKKLIIVESPTKAKTIANFLDQNYQVIASKGHVRDLSKYAMGIRIQEDKFIPKYIVDKDHEDIVEQILSLAKSASQIYIATDEDREGEAIGYHIAYLIKENQRTSQTKKMSANQILQETLDLEQQTNHAPSSNPIFHFPRIVFHEITKSAILHALKHPKTLDVYKINAQLARRLLDRIVGFSLSSLLASKIAKGMSAGRVQSAALKIVVDREREIQAFKPLIYYNIEGIFEGCIEASLESYLGEKIKKQSLTDAPDALKMVAHLRAQTYQVQEITHKNKTSPSPPPFMTSTLQQSASTHLGYGPSKTMGIAQRLYEGVATPEGMSGVITYMRTDSLNVAKEAIKAARDFISTTYGAPYLPNKPKTYTAKNKAAQEAHEAIRPTNLNFTPTIAKDYLKPEEYRLYTLIYNRFLASQMTDALFENQTLRLSCADGTFKASGRKLIFDGYHRVLGECDRDKLLPALQKDQSVRLDKLEAKKCSTEPPTRYSEASLIKTLESLGIGRPSTYAPTIALLANRSYVKLENKQLVPTEDAFVVIGILEKHFSEIVDAAFSAGLEDKLDAIASSKASWQQVLFDFYTPFMDKIEAGKAQIASQKSSVPTGEFCPECGLELVQRKGRFGEFVACSGYPKCKFVKPPSEQTPTPLEPCEKCGKPMVLKKGRFGEFVACSGYPQCKNIRSKAPQLKEEKVAGVCPECGGHVVEKRGRRGLFYGCANYPQCQFISNYPPSDQKCPECGYVLVFKAYKRKPSVWACLKCAFTRLADV
(1158) DNA topoisomerase I [Helicobacter bizzozeronii CIII-1]
3
MQKPDVIIIESPNKIKKIASITGAKVLATIGHFMELEGIEGENFKPKFAYRADKKQQIYAMIEQCKGKRVYIATDPDREGYAIGKMFYEKIKNVAKEVFRAEFHEITESGINKGLQSALLFANTNSNHYESFLARSVSDHYIGFTLSPYLGDCLQQRKGNSVGRVQTPCLKLIVDRDKEIEAFKALPESQKVSYQIQAKIYDTHNREVILRHCNGEGKEIKYESQEQALAMLAPLKECKVALVLDIKHFTISSPPPKPFITSSLLKVGSTQLGLSTQQIQEHAQKLFEAGLITYIRTDAETLSQEFLYKAEKFYQPIYTNLYERRAYKAKNSQAEAHEAIRITHCHKFEDTQDILAQAGIADNQAQALYTLIFQRTLESQGKSAVYAKQDLQFKIKDHFFKCSVRSLKQAGYLDMFRHTEQAKSAEQAENEQNAHLDLKTDSTISLLSLDIAPIQKHAKSAYVEASFIEVLEKNGIGRPSTYASYLPKLTQREYIQITPDKKRIVNATHKGKQVISVFEASPYSWIVDTQFTALMEELLDKIVRQECSYVEYMQMIAQRCPQMPSQTPREEYPTRAPRESQVKYVQDILRDLKMELPSEFADYARDDKITKAFLDKFIPKHKEAREKAKQEGHYLGDNTPASKPATAKQVAFAESLSQKHNVKLPKDYKSNMQVCSGFIEEWKGK
(1815) DNA topoisomerase 1 [Sulfurimonas denitrificans DSM 1251]
1
MNLIIVESPAKAKTIKNFLGKEYEVIASKGHIRDLPKSRFGITVDENSHLIPAYSVAKENAATVKEITTLAKKSDIIYIATDEDREGEAIGWHIAHAIKKDPAELPRIVFHEITKTAIENALLNARKIDMDMVNAQQARRILDRVVGYKLSPLLSSKIQKGLSAGRVQSSTLKLVVDREREIRAFVAEEYWTIDTLFAKDIEASLISHMGEKLSKLSITNKADASSIVKSVKEDSFIISKIETKERRSATPPPFMTSTLQQVASSKLGFTPKKTMMVAQTLYEGVKTPSGTSGVITYMRTDSLNLAHEALTAVRGLIESRFGKKYLPAEPKIYTKKAKGAQEAHEAIRPTMLAFTPEVAASFLKPDEIKLYRLIYERFVSCQMNDAVFEQQSIIFSGANNEYKAIGRKLTFDGFYALTGAEDKDKLLPSLSEGQSAQIQKIESTQHFTEPPARYSEAALIKKLESEGIGRPSTYAPTIATLSNRTYVTIEKKQIIPTEMAFTVTEILEKNFSNIVDLSFTANMEEKLDEIAEGQNDWQKLLSDFYGDFLAQVEEGKTNIVSLKMATPLGRACPKCGEELLLRSGRFGEFIACSAFPKCKYTEQVEGEKKEGEENAQSSSSDEICDKCGKEMVTKNGRNGPFLACSGYPDCKNTKSINVEEKTSETPCPDCGGKISLKNSRRGPFWGCENYPTCKFISKFEPSKYKCRESGCDGALAFRVFRGKEIYECIKCKAKTPAQEIVAE
(1058) DNA topoisomerase 1 [Geobacter metallireducens GS-15]
1
MPQHLVIVESPAKAKTIEKFLGKDFRVMASYGHVRALPSKQGSVDVANDFEPKYAILPESKRHIDAIKKELKESDILLLATDPDREGEAISWHLLAALGMDKKKNAVPVKRVVFHEITKDAIVHAVENPRDISLELVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIKAFQEQEYWTIGAELGTGKGQKFSANLVEAEGKKLGKFDIPDGTAADRLVKALENGAYTVDKVAKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGVAVGDEGLVGLITYMRTDSVVLSNQALQEAHEVITSLYGKEYALAKPRFYKNKAKNAQEAHEAVRPTSIARTPVEVKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGYRFRAAGTVIRFPGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLQKLVPEQHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLLERKYARLDSKRFVPEDVGMVVNDLLTNHFTQYVDYNFTASLEEELDRVSRGEKQWKPLLHDFWGPFSSLLKQKEGEVSKADLTTEATDELCPDCGKPLVVKLGKRGKFIACSGYQEGCTYTRNIAQGEQQEPAEPVFSEEKCDKCGSPMLIKDGRFGKYLACSAYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPGPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
(1189) DNA topoisomerase 1 [Geobacter uraniireducens Rf4]
1
MPRHLVIVESPAKAKTIEKFLGTDYKVLASFGHVRALPSKQGSVDIEHDFEPKYAVLPESKKHIDAIKKELKNSDSLLLATDPDREGEAISWHLLAALGLDKKKPAIDIKRVVFHEITKGAIIHAVENPRSISHELVDAQQARSVLDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLVCEREKEIQAFTEQEYWTIAAQLATGAQQNVTANLVEAEGQKLGKFGIPDKAAAERLTEILANGSYQVDKVTRSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSIAQKLYEGIDVGEGTVGLITYMRTDSVVLSQQALDEAHEVITSLYGKEYALAKPRFFKNKAKNAQEAHEAIRPTYICKTPVELKKFLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGEGYKFRAAGTVIRFPGFMKLYIEGVDDETEEKEGVLPPLNEGDPLKLKELLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLVERKYARLDKKRFFPEDVGMVVSELLVNHFTKYVDYNFTASLEEELDRVSRGEKKWKPLLHDFWEPFQTLLKQKEGEVNKSDLTTEATDEICPECSKPLVVKLGKFGKFFACSGYPECKYIRPLDKDKKDVAEPVISEEKCDKCGSQMLIKEGRFGKYLACSAYPACKNIQPLVKPKGTGIKCVECGEGELTEKKSRYGKMFYSCNRYPQCKFALWDLPVEKPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYKEGGKEK
(1164) DNA topoisomerase 1 [Nitratifractor salsuginis DSM 16511]
1
MKNLIIVESPAKARTISNFLGKDYKVVASKGHIRDLPKSSFGITVEEGKFIPKYTVPREASPTVKELKKLAKEAETVYIATDEDREGEAIGYHIAKAIGKDPEELPRIVFHEITKSAIQHALENPRRIDMQSVDAQQTRRLLDRIVGYKLSPLLANKIQKGLSAGRVQSAALKIVVDREREIKAFKPEEYWSIKGIFDKTVDADIYSFEGKKIEKMTLKNGEEANKIVESAKEESFKVASIETARRKSKTPPPFMTSTLQQAASTQLGFSPKKTMMVAQKLYEGVKTHKGTMGVITYMRTDSLNLAKEAVAEAREFIEKNFGEKYLPAKPKFYASKAKGAQEAHEAIRPTMTEFTPKLAAKYLAPDELKLYRLIYNRFLACQMTEAEFETQTILFAGEKSVFKATGRKLIFDGFYRITGYNEKDRLLPELKEEQPVELTEIKAEQHFTEPPARYNEASLIKKLESLGIGRPSTYAPTITILQNRKYIEIEKKRIHPTEIAFTVIEMLEKHFPEIVDSNFTARMEETLDKIAEGKEDWQKVLWEFYQPFIEKIAEGKKNIPSQKMAEPIGEKCPECGAELLKRKGRYGEFIACSNFPKCRYSRNIDGTEPEKPEETDEICDKCGAPMVIKNSRRGKFLACSAYPKCKNAKPLTPPKELAVPCPECGGKLIERQGRRGTFYGCANYPKCKFIANFEPVDKKCPECGYLMGVKHLKSGDVYVCFKCKHKVSAEAET
(367) DNA topoisomerase 1 [Campylobacter curvus 525.92]
1
MKDLIIVESPAKARTIKNFLSKNYDVIASKGHIRDLPKTSFGIKIEDDKFTPEYRVSLDHSKIVKEIKELAKGANEIYLATDEDREGEAIAFHIANAIGKEVSALPRIVFHEITKTAIDNALKHPRKIDMNSVNAQQARRLLDRIVGYKLSPLLNLKIQKGLSAGRVQSAALKIIVDREREIIAFKPVEYYSIDTKFKTDLDAELVKFEGKKIEKLTITNADRARYIVDALKNEKFSVREIESKDRKIQPSPPFMTSTLQQSASNRLGFSPKKTMMLAQTLYEGVQTHEGFMGAITYMRTDSLNLAKEAVEAARELIKNEFGKDYLPPKAVHYATSSKGAQEAHEAIRPTNLNFTPEIAAKFLQKDELRLYTLIYNRFLACQMSACVSQTQNLFVVSDNGEFKISGRKVLFDGFYRVYGDMDKDKILPNLNVGDEMKLESIKESQHFTEPPARYSEAGLVKKLESLGIGRPSTYAPTISLLTSREYVRVEKKQLIPNDVAFSMIGVLEEHFNDIVDSEFTSHLEEKLDLIAEDKADWQKVLSEFYYPFMDKISEGKTGIKSLKVATPIGEKCPQCGGELVKRKGRYGEFIACSNFPKCKYSRNIASQANDAGAQTTEPKAKKELVKLDVPCPKCGGVIVERFSRRGKFYGCANYPKCDFISNYEPTEHKCSECGSMMVKKELKKGTFLECTKCKHKVQIGEN
(1684) DNA topoisomerase 1 [Sulfurospirillum deleyianum DSM 6946]
1
MEKSLKNLIIVESPTKAKTIKNFLGKNYTVVASKGHIRDLPKSSFGIKIDNQTFIPEYRVPKDHASVVKEIKELAKEADQVYIATDEDREGEAIGFHIATAIGKDPKSLPRIVFHEITKNAITHALENPRILDESSINAQQARRLLDRIVGYKLSPLLSSKIQKGLSAGRVQSSTLKIVVDREKEIRAFKEEEFWSIDALFNKTIEASLVEFEGEKIEKMSIGNQERAYAIKEKLLKEAFHVALLEKKERESSPSPAFMTSTLQQSASSALGYSPKKTMMLAQTLYEGVKTHQGVQGVITYMRTDSLNVSKEAIEAAREQILSQYGKTYLPEKARFYANKSKGAQEAHEAIRPTILEFTPAIASAYLAPDELKLYALIYNRFLASQMNNARFESQTLIFESQSGKFKASGRKLLFDGFYKVYGDNDKDKLLPDLALKQEVTLSKLDANQHFTEPPSRYSEASLIKKLESLGIGRPSTYAPTISVLSARDYINIEKKQIVPTEVAFQVTELLEQHFPQIVDSSFTSTMEERLDLIAEDKEDWQAILWNFYEPFDAQVAKGKTEIQSQKVIVFTGEMCPECGKELVRRKGRFGEFIACSTYPTCKYTQNLKKVSESAPKEKVTLSVPCPECGGEIIERSSRRGKFFGCGNYPKCKFISNYEPTDKKCPECGYIMAKRELRKKEIYECIKCKHKEEA
(1138) DNA topoisomerase [Desulfobacterium autotrophicum HRM2]
7
MTELILTEKFSVASDFAKALGVKNKKDGYFEGDAHVITWAVGHLVELFEPDDYDAGLKKWRVETLPLIPERFRYKPITRTLQQFRTIKALLTQRQFDRIIIATDAGREGEVIARTILLESGFRDKERIMRFWTSQALVPKVVRDTMNQLKPITDYDRLWRAGYYRQVSDWLVGMNLTRLMTVRLGDLFSVGRVQTAVLAMLVDRRNEREHFIPETYWNFKVLFSGDKGRWTGRWFKEKETRITDKPQADALLERFQAEKAPGVVVSMKKETKQEPPPLLFSLTDLQQEANNRFGFPAKKTLAIAQALYQDRKCLSYPRTDSKVLGTASLGLVNTVLGKLEQACPDLFAFVDPKRVSLSNRRVFNDAKLTDHHALIPFKPISEAASRDEKLLFDLVVRRFAAAFHPDCRFESTRVVTLFAKETFQTRGKVILDPGWQRVYGTGIRDKAEAEIIPPLVEGDEGAVEKIEREEKQTSPPPDYSDSLLLKDMTNPGRYVAEEEIKRLYRGDIGIGTQSTRAQIIETLISRGYVQRAGKRLLATDKGGYLVTQLRKCPISSVLTSPEETARWEMQLNTIALGEGSDIRFLDHIKAFVTNAVAELKSAGLNVKLFKAEQPQAAVIGICPACGKAVRENPKAFSCEDRGCEFVIFKRIAGKSISAKMATNLLQYRKSGPFKGFISKKKKRFSASLKIVNENGHWKVTFDFNNQGKASSNNGQASPDPRRSISTVERVRSEPRGPESLSAPGSEPTQGAETMRCPLCNGTIIEGNRGFGCSNWRPEHGDCRFVIWKEIAGKTLTLQNLETLIAGKKTRPYVLKNSNGDKFKASMKMVKAPGQGVAIEVEPQGEGQGFKVLCLR
(306) DNA topoisomerase 1 [Desulfobacterium autotrophicum HRM2]
1
MKKPLLIVESPTKVKTLKKYVGKDYNVTATVGHIRDLPPKELGIDIEDDFKPKYITIQGKTKVIQAMKSAAGDTDTVYLAPDPDREGEAIAFHAAEVLKKKGRTFYRVLFHELTQKGISEALENPLDLNHDRYEAQQTRRSLDRLVGYQISPLLWRRVQGGLSAGRVQSVAVRIICDRERIIRAFEPEEYWTITADLATDLPPTFTAALARIDNKKAVIPDQQTAEKIVGELENAAFVVEKIVSRTIKRNPLPPFITSKLQQDAINRLRFTAKKTMLVAQQLYEGIEIGTGGPEGLITYMRTDSIRIADEAAQEALEHIRQTFGPEYALATPRFFKNKNKAQDAHEAIRPTSVLNTPERLKSFLGEDQFKLYELIWNRFVASQMAQAIIDQNTISIQALNYTFTVGGTTVKFPGFMALYAAIDEKADKAKQKLPIIEQGMGLERKAIIPKQHFTKPPPRFSEASLVKELEENGIGRPSTYASILSIIRDKGYVELINRYFVPSELGFIVNDLLMTSFPEILDTDFTARMENDLDEIESGTKHSLGVLKAFYSTFKEKLDHAKENMLSVKGVGIPTGLSCPLCGKPLNIKMGRNGHFIACTGYPECSFSSNYTRDEKGAIQILETKTDNTKVKDCIKCGSPMVKKEGRFGEFLACTGYPECKHTESVNGDAGGRETGAKCPEPLCNGVIVEKRSRRGKTFFGCNKYPECTFASWDPVVNKPCPKCNSSYLIEKQTKKEGKFLKCPNKECTYKESLDD
(1786) DNA topoisomerase 1 [Campylobacter hominis ATCC BAA-381]
1
MKNLVVVESPAKAKTIGKFLGDNYNVIASKGHIRDLPKKTFGIKINEKHFEPVYEISEDHAKIVSEIKKLAKKADQIYLATDEDREGEAIAYHIATAIGKEPANLPRIVFHEITKTAIENAIKNPRALDTASVNAQQARRLLDRIVGYKLSPLLSQKIQKGLSAGRVQSSALKIVVDREREINAFKPEKFYTVNMIFKKDLEAEFVKFKNKKIEKMSIKTAKEADEIVQILCDEKFEVSKIESKDRKTNPYPPFMTSTLQQNASTALGFSPKKTMNLAQSLYEGVNAPNGGAITYMRTDSLNIAKEAIVSVRDMIKNEFGSEYLPKSANFYATKSKGAQEAHEAIRPTDLKFTPAIAAKSLPKDELRLYTLIYNRFVASQMNPCVSEIQNVFAKSGSSLFKILGRKVKFDGFYKIYGENDKDKILPDFKIGDELKVQNLKSVENQTEPPARYSEASLIKKLESLGIGRPSTYAPTLSLLISRKYVNTEKKQLVPTEIAFKIVEMLEQNFNNIVDSEFTSKMETKLDEIAEKSADWQEILADFYYPFMEKIAIGKKNIKSQKVAEPIGEKCPECGGELLKRNGRFGEFIACSNFPKCRYSRNLSGEQKIKKEPAKIGVKCPECGGEIVERVSKRGKFYGCSNYPKCNFISNYKPTNEKCPECGEMLFKKSLKKGDFLYCAKCKFQKAIDD
(1151) DNA topoisomerase 3 (DNA topoisomerase III) [Campylobacter hominis ATCC BAA-381]
3
MKLFIAEKPALAKSIAAGIDGEYKNGDGFFQKGENIITWAFGHLLELYMPEDYDENFKKWDLKDLPLKIDEFKYKPIQSSKEQLKIICNLIKRSDVDTIINCGDADEEGQILIDEILKYANNKKPVLRLLLHDLTEKGVRSELKNMKSNNDFSNLSECGFARSIADWIVGINLTRAYTTKAQNNGYKGVISVGRVQTPILGLVVSRDLEREGHKSSFYYTLTGKFKTHQAEILANLKTDEKITDENEANEIKNICLGKNGILNVTNENKLEYPPLPYNLLNLQADCSKKFNFKPDKTLKITQDLREKYKCITYNRSDCEYLPVNMWESSTNVLNSIKSNLSDFENIIKNADPNLKSRAFNDEFITAHFAIIPTETTFDFNSMSKDEQNVYKLISKRYIAQFYEPMQYLQTNIEILINDYKFTTSKKKITKNGYLSLFSGENDSEQKNDDEVENSFDLSLLESGNCQTLNIEINKKQTKPKPYYTMPTLLKDLTSISKYVKDEKIKTLLKEKDKDKKGENGGIGTPATRSEHIKNLFEREYIREEKKSIISTKKGRDLIALAPKILSTPDMTALWYEQQLEIQNGNLSKDDFLNRVFDEVEEQIELIKNNALLDKNFNGIDKTYPCKCGKGFLQKRHSQKTGKDFWGCSNWKNGCSEIYPDLNGKPNIPKYFCPKCGSALNRWKNKKGDGYYWSCSGWKTKGCQIGFINDKNGKPEI
(133) Reverse gyrase [Caminibacter mediatlanticus TB-2]
6
MLEAIYKNRCVRCLGDITSLRLSRGEFCDKCMQEIENLENCNELLNFKKFCEANKKLEEFNNFFKEKTGSTLNSIQKMWAKRYFLDNSFSLLAPTGIGKTTFGLLLSAFVNNSYIIFPTKLLVSQAIERFKLWGIEVLAYTGKKNEKEKIKNGEYNILITTTQFLYKNKKLINKNFDLVFVDDVDSILKSGKKIDDILGLLGFNEEDLQKAMELINKKEYEKISEIAKKKRGNLIVSSATANPKSKRILLFKYLLGFEVSRPNLTLRNIEDLFDEKFSWELSIEWIKKLGIGGLLFLPGNETKEKLYEYLEFLNNKGIKAYSYEEFNDHIDEFKKGECYFVGFASYRNPLARGIDLPQAIRYTLFVGVPKMEFNLNEDNFRSLYLILLSVFPYLMKNNLLDKKEAIEFQNYINFMKKYVFYTILHPKIEEKLRLISTKIKILIKKYENEIKNSPEISFDGEKIITADITGYIQASGRSSRFFNGHLTKGLSLVLVDNKKAFFSLQKKLKWFSEAQFKRVDEVNLEEILEEVEESRKIKKEIKLKTSFVVVESPTKAKTISSFFGKPSKRIINGVSVYEILLEDRNLVIAASVGHDFDLVEDEGDFGVIKKYIPIFKVLGEKDNILKALNLTSSEVEEVYIATDPDREGEKIAFDLTLNNKPFNLNIKRAEFHEITKYAFEDAIKNPREVDLNLVASQFVRRIADRWIGFKVSLYLQKLLKNAHLSAGRVQTPVLKWICERTSKLKEKIYIVRIIFDEIKVDFEFEDKKEAENFYNSLGEYIEIKKISSKEESLLEKPFNTSELLKEASIKLRFSPQKTMQLAQELFENGLITYHRTDSHRISSLGMSIAKEYIKENFGEEFIKLRSFEEGGAHEAIRPTSSMDSEDLRSFIAFKNLELNNEHIKLYDLIFRKFIASQMKEAKVLKETYDILGKNEEFITKIIEDGFNLIYPIKVYNVNEGKKKIEKLKLQKSKYPPYTYADIIELMKQKGIGRPSTYAITIEKLLDRKYVVEKNGYLFATKLGFKVIDIVFNSEYKEFLDEEYTAFLEEIMDKVEKGEVNYKIILEELYQKVILNQK
(1564) DNA topoisomerase 1 [Caminibacter mediatlanticus TB-2]
1
MAKKLIIVESPSKARTIKNFLGKEYEVIASKGHIRDLPKTSFGIKIEEDKFIPQYRVTKDHQSVAKELKEKAKKAETIYIATDEDREGEAIGFHIAHVIGKDPSSLPRIVFHEITKTAIKNALKNPRKLDIDRVNAQQARRLLDRIVGYKLSPLLNKKIQKGLSAGRVQSAALKLVVDREREIKEFIPKEYWSIEGIFKEVEGNLIKYNGKKLEKFDLKTRDEAEKIVNELKPLEYEVSKIEKKTTTTKSPAPFMTSTLQQVASSELGFSPRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQEAAINFIKENIGSEYAEAKTYTTKNQTAQEAHEAIRPVDVRLTPDDLKNYLSKDELKLYSLIYNRFLASQMKDAKFETQNIYLTNEKGEFKISGKKLIFDGFYKVYGKRGADTLLPEFKEGEKLKPEEIKATQHFTKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEIKDKKLHPTEIAFNVIETLEKHFPDIVDAKFTANMEEMLDEIARGNKDWQEMLKEFYNPFMKLIEKGYEEIPSQKIAKPTGELCPECGNPLVIRKGRFGEFIACSNFPKCKYTRPIEEKEEKKVDVKCDKCGADMVIKRGKRGEFLACSNYPECKNTKPLNPPEVLEDVKCPECGGDIIKRKSRRGEFYGCGNYPKCNFISKYRPVNEKCDECGYMMAKRTYRNKEVLECIKCKARKEI
(1046) DNA topoisomerase 1 [Arcobacter nitrofigilis DSM 7299]
1
MKNLVIVESPAKAKTISKFLGSEYKVMASMGHVRDLPKSKLGFDPADNFKPQYLISTDKRKVIADLKKEITKDTTIYLAADEDREGEAIAWHLIPALKVEKNPLKRIVFHEITKGAILKALENPREVNQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRENEIRAFIPEEFWKIKADFINPQLNTELAKIDGKVKKIKNEQEAKVIEASINQGEFELFDIDESESKRNPAAPFTTSTLQQEASRKLGYSVKQTMVIAQQLYEGNIQNIPNHTGGLITYMRTDSLNLSTVATSAAKEVIEKTYGAEYSLKSPRVYKSKAKGAQEAHEAIRPVDLSLKPSMIKAYVDNAQFRLYSLIWKRTLATQMQTAKIANTTYKISAGKDKEYEFQVKGQRIIFPGFMKVYTEGSDNPESALDSSEKILPSIKVGTKLDLEKLDLEQNFTKPPARYTEASLVKKLESEGIGRPSTYAPTISTIQAREYITKSEDKKLIPTPTGEIVNSFLTDHFPNILDLGFTAKVEEEFDDIADGKIAWQQVMKDFYGDFKKTIDEKEESVNKEDYLQIREIGTDPKSGKPVSARVGRFGPFVQIGTKDDEEKPLFVAIPAHLNMDTITMDEAMFLFTLPRVVGQTADGEDIKANIGRFGPYLQVKTKYYSLKEDDPYKIELPRALELIKQIDEEKAKATIKNFEKEKIQVLDGRYGPYIKQGRKNYKIPKGKDAASLELEDCLSIIENDSKTSKRAPAKKTAAAKTTTKTATKKAPAKKAPVKKTTTKKTTAKKEK
(974) DNA topoisomerase 1 [Helicobacter mustelae 12198]
1
MKKLIIVESPAKAKTIQNFLGEEYQVIASKGHIRDLPKMRFGIHIKQESFEARYVIDEDHQEIAKNIKELAKQSSQVYIATDEDREGEAIGYHITQAIAKDPQSFPRIVFHEITKTAIQDALANPRNIDMNKVNAQQARRFLDRIVGFKLSSLVSSKIAKGLSAGRVQSAALKIIIDKEREIQKFIPLDYYSIEGNFLGLSAQLIAYQGKKLKEQEITEEARAKQMQENLQKNLYTIGDLQKKSKKSPTPPPFMTSTLQQSASNLLGYSPTRTMSIAQKLYEGVQTHQGYMGVITYMRTDSLNIAKIAQDQAREHILKAFGQAYLPKKPKIYATKNKSAQEAHEAIRPTNLDFTPEIAKNYLKNEELKLYTLIYHRFLASQMEDAILESQSITFIGEEGEFKANGRRLLFDGFYKVLGNEDKDKLLPELEVGAKIKPQSLEVNKHTTQPPARYSEASLIKILESLGIGRPSTYAPTIALLNSRYYIKIENKQIHPQESAFKVIEMLENHFDKIVDATFSASLETKLDEIAENKQNWQKFLWDFYEPFMEQINAGKTDIASQKMKIPTGEYCPQCGSELLLRESRYGEFTACGAYPKCKYIKPQEEEGEKDPESCEKCGKPMVTKMGRNGSFLACSAYPECKNTKSLLAKPSQQKVLEGVACPECGGEILLRNSRRGAFYGCSNYPKCNFLSKFPPTNHKCPECNYLMNDRTYRGRAIFECIKCKHRVDQ
(1557) DNA topoisomerase 1 [Myxococcus fulvus HW-1]
1
MATRTKKKVEETEAAEEKAPAKKAAAKKKPAARKKTVAKKKTAARRRTKKGDEDALPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTVKASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREGEAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQISPLLWKKVRRGLSAGRVQSVAVRLIVEREEEIKAFVPEEYWTLDALLEGPSGPPPFKAKLSKVDGKKVELKDRATTEGLVAELQSASFSVAKVDRRERRRNAPAPFITSKLQQEAANRLSFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFLPDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKGFFEAMGEEDMYRLYELIWNRFVACQMKPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEGADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILSTIQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSVLHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCKNTKDFKRDAEGKIVMVEEETTDELCEKCGKPMVIKRGRFGRFLACSGYPDCKTSKPISIGVSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRDGPYVACPNKECDYRREITEQPAGPGGSPEASSAA
(1338) DNA topoisomerase 1 [Geobacter sp. M18]
1
MSQNLVIVESPAKAKTIEKFLGPEYKVLASFGHVRALPSKQGSVDVEHEFEPKYAVLPESKKHIDAIKKEMKGITSLLLATDPDREGEAISWHLLAALGLDGKKKASFDIKRVVFHEITKDAIVHAVQHPRGISVDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIGAKLETAKKQALTAALVEAEGKKLSKFDIPNQEAAFRLFGLLGGKEFPKQEGEEGSAPLVVKAPVNPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEDARQLITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYISKTPIEVKKFLTSDQFKLYDLIWKRTVACQMAEALLDQTSVEITAGEGFRFRVAGTVIRFAGFMKLYIEGVDDEAEDKEKEGMLPPLKEGDILKLQQLLPEQHFTQPPPRYTEATLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFNQYVDYNFTANLEEQLDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVSKSDLTTEATDEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEELCDKCGSHMLVKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCTACGKGELIEKKSRFGKLFYSCNRYPECKFALWDQPVQKPCPKCGFPLLVKKVYKREGEFLKCPKEGCDYQSNKE
(95) DNA topoisomerase 1 [Desulfobacca acetoxidans DSM 11109]
1
MTKSLLIVESPAKARTLQKYLGKDFEVRASVGHIKDLPKKELGVDVEKNFIPKYVTIDGKTKTIQDLKRAAHDVEDIYLGPDPDREGEAIAWHIAEVLKSGKHRFHRVLFYELTPRAIQEALAKPMELNRPRYEAQQARRILDRLVGYQISPLLWEKVKRGLSAGRVQSVALRLICDREREILAFVSQEYWSLTAHLKAEQPPPFQAKLIRYKGKKLELAKAEQTQAVVAALEGAQYTVTAVEQKERQKKPLPPFITSTMQQEASRKLRFAAKKTMQVAQRLYEGKDLGAAGPVGLITYMRTDSTRVAGEAVAAVRDFIRQEFGPDYLPAKPNAYKSRKTAQEAHEAIRPTDVSRTPAAVAPFLEKDELRLYELIWKRFVASQMEPARLLVTTADISANHYTFRATGTVVKFPGFTVLYEETPDAAGEEEDIKLPPLKVGELLELLQLEPKQHFTQPPPRYTEATLIKELEKQGIGRPSTYATILSVILGRLYVAKIKAGFKPTELGLMINDLLVASFPKIMNVGFTANLEDRLDAVAEGEVIWQEVLRDFYGSFSQELQEAKQVMPRVKSLATGLTCPQCGAELLIKWGKTGEFLGCSGYPECRYTRNFSRDEQGRIVPEEKNNVPAPDLPEITEVCPKCGQTLVAKQGRFGPFLACPGYPKCRYTRSLQEEEGEVEAVPCPQPDCTGVLRARKSKRGVFYGCSNYPECTYALNYPPVAKACPQCGFPVMVRKELKKQGKILACPQKSCGYTEPDLDEPGTD
Family distribution
Taxonomy tree
delta/epsilon subdivisions