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Taxon : Burkholderiales
Informations
Name
Burkholderiales
Rank
order
# topoisomerases
71
Lineage and sub-taxa
Lineage
Bacteria
>
Proteobacteria
>
Betaproteobacteria
>
Burkholderiales
Sub-taxa
Topoisomerases
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Name
Family
Sequence
(1706) DNA topoisomerase [Burkholderia cenocepacia J2315]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDDFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPQAIRDGFANLRSDSDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFIPRDYWEVKAEFACAGGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLSTVQSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEFRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIPEVEELLQKKEIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMGKLLADGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDAETVTEGAEEKPAPARKTAARKTTARKTGS
(892) DNA topoisomerase [Bordetella avium 197N]
5
MNKTLIIAEKPSVALDISRALGGFAREGDFFESESYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSSERLKLLVRLAKRKDVDTIINACDAGREGELIFRYIIQYAGVKKPIKRLWLQSMTQAAIREAFANLRDDVQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVAERESRIRSFVPRDYWEVHATFVAAAGLYEGRWIDPDFKKDERDPEKRESRLWSAAAAQSVVAACREQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLSLAQTLYERHKALTYPRTDSRYLPEDYVNTVRQTMRALSEGGSNAVGGLARHAGTVVSNDWVKLHRRIFDNKKVSDHFAIIPTLQIPHDLSEAEGKIYDLVLKRFLAVFFPAAEYRLTTRLTEVQGHRFKTEGKVLVAPGWLAVYGKEAQGEDANLVPVADGEKVRTEDVRAEALSTKPPARYNEATLLSAMEGAGKLVDDGELREAMSERGLGTPATRAAIIEGLLNESYLRRDGRDLVPTAKARQLMTLLAGLDVAELTSPELTGEWEHKLKQIEQGGLDREAFMREIAQMTQVIVKRAKEYERDTVPGDYATLKTPCPHCGGVVKENYRRYACTQCEFSISKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISDEYKLEFDFGQSDEEDDTPVDFSGHTPVGACPKCHSQVFEHGMSYVCEKSVGPAKSCDFRSGKVILQQEISREQMSKLLSEGRTDLLDGFVSSRTNRKFKAFLVRQPDGKIGFEFEPRGDKPARRAAAKKAPAKTATKTAAKTAVKKAASKTTTKTASKTATKTATKTAAKKAAAKKTAA
(1723) DNA topoisomerase [Pusillimonas sp. T7-7]
5
MTKTLIIAEKPSVALDISRALGGFTREGDYFESEQYVLASSVGHLLSLVAPNDPVRGKWSFTHLPVIPPQFELGPTDKRSSERLKLLVKLLKRKDVDAVINACDAGREGELIFRYIVQYSGVKKPVKRLWLRSMTQAAIREAFANLRDDDTMKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNEREERIRKFVSRDYWEVHATFVAAAGFYTGRWFDPKFVKDERDPEQRDSRLWSNTAAQTIVMACRGQSGKVTEESKPSTQMSPALFDLTSLQREANSRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYISTVQQTMEALSEGGSSAVANIRPFAETICKQKWVKPNRRIFDNKKVSDHFAIIPTLQVPRELSEAEGKIYDLITRRFLAVFFPAAEFRITTRITEVSGHHFKTEGKVLIAPGWLAIYGREAQGDDTTLIAVSEGETVKTDEVEAKGLATKPPAHFNEATLLSAMEGAGKLVDDEALREAMSERGLGTPATRAAIIEGLLNEGYLRREGRDLIPSAKARQLMTLLSGLGVNELTSPELTGEWEHRLKQIEQRELDRDAFMREIAQMTQVIVKRAKEYERDTVPGDYATLSTPCPKCGGVVKENYRRYACTNCDFSIGKHPGGRTFEIDEVEELLTKRELGPLPGFISKMGRPFAALLRITDEYKLEFDFGQKDDEDTEPVDFSGHTPVGECPKCHHKVYEHGMNYVCEKSVGPDKTCDFRTGKMILQQEISAGQVSKLLSEGKTDLLEGFVSSRTNRKFKAYLVKQPNGKIGFEFEPRPVKAGAKTAAKKAASKTASKTAAKTATKTAAKKAAAKKAATKAPAKKAAKKTAVKKAAVKKAVKAAPVTASGDDDPPF
(723) DNA topoisomerase [Achromobacter xylosoxidans A8]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESERYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPEFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIIQYAGVKKPIQRLWLQSMTQAAIREAFANLRDDSQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVAEREERIRRFVPRDYWEVRATFVAAAGLYEGRWIDPQFKKDDRDPEKRESRLWSEAAAQSVVAACREQPGNVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYIATVQETMRALAKGGSNAVGGLSRHAETVVGNQWVKPNRRIFDNKKVSDHFAIIPTLQIPHDLSEAEAKLYDLVLKRFLAVFFPAAEYRVTTRMTEVQGHRFRTDGKVLVSPGWLAVYGKEAQGEDANLVPVADGETVRTEDVEAVGLSTKPPARFNEGTLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEVYLRREGRDLVPTAKARQLMTLLSGLDVTELTSPELTGEWEHKLKQIEQGGLGREAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGAVVKENYRRFACTACDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISDEFKLEFDFGQSDEDDNEAVDFSGHTPVGSCPKCQSRVFEHGMSYVCEKSVGPEKSCDFRSGKVILQQEISREQMEKLLTNGRTDLLDGFVSSRTNRKFKAFLVRQPDGKIGFEFEPRPEKPGRAPAKTAAKTATKTAAKKAPAKKAAVKKTATKTATKTAVKKAVKKAAPKKTAA
(834) DNA topoisomerase [Achromobacter xylosoxidans A8]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDASADDAGRCLQQPIAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRTQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTVADLSCGQQKLVATGKQVVVKGWRLVLAEPEREGSADEDGDAPRSQVLPALRDGMACQVAGADIKALKTMPPKPYTQGELVKAMKGVARFVTDPRLKQKLKDTTGIGTEATRANIISGLIARGYIVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPACKGTLPVATGTSRRGASRPRRTSGGGCKGA
(172) DNA topoisomerase [Taylorella equigenitalis MCE9]
5
MSKTLVIAEKPSVATDLSKALGTFKKETGFYENDHYVISSSVGHLLTLFNPDDAVRGKWSFTNLPAIPSKKFEIQPIDKKSKERLTLLVKLIKRADIELIINACDAGREGELIFRYIMQYAKVKKPIKRLWLQSMTKQAIQEAFENLRSDESMKPLEDSARSRAEADWLIGINGTRAMTAFNSKGGGFNKTPIGRVQTPTLAIVYDRDQKIRAYEPKDYWEVVATFVASAGVYEGKWFDPEFKKNPKDPDARESRLWDANTAKTIVLACKGKEGTVTEETKENTQNSPILFDLTTLQREANSKFGYSAKTTLALAQALYEKHKLITYPRTDSRYLPEDYLNTVKENIKSMSSDSSSLHTGHKEFAQKIISNKWVKSNKRIFNNSKVSDHFAIIPTSNSTATLSEAEFKVYDLICKRFMAVFYPPAIYNVTTRITEVISYKFKTEGKILVSPGWLEIYGREEMDETLPPIKANETVLTESIESIQNKTKPPAHFNEATLLSAMEGAGKLVDSDDLREAMSERGLGTPATRASIIEGLISEQYLRREGKDLITTIKTKQLMTLLHGLSINELTSPELTGEWEYKLRQIEEGNLDRDKFMQEIAKNTQIIVKRAKEYEHDTVPGDYATLETPCPVCGGVIKENYRRYACTDCDFSITKNPGSRPFETAEVEEFLTNRSIGPLSGFISKMGRPFAAILKLTDDNKLEFDFGNDNAQEKEDIDLTALEPVGKCPKCSSNVYDTGLNYACEKQIKDKSCDFKSGKVILQQEIPLEQMQKLLSNGRTDLLEKFISNRTKRAFKAYLVLEKNGNVGFEFEKKSSTGRKSSKK
(559) DNA topoisomerase III [Comamonas testosteroni CNB-2]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFEKHDDYFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPRFDLKPVDKTKTRLNAVVKQAKRKDVTELINACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFNNLRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHGTFDAQAGQYLGKWFNPQWKKSDDAEAKADRLWNKADAEAIAAAVQGKPAQVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFDMLATSGMRHLAPFAQQAINDNYIRPTKRVFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISKVEQHSFKTEGKVLVKPGWLAIYGKEAANEVEDAKEGDKGQPLVAVQPGEQPRTHHADVKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLEVEELCRADLTGEWEFKLSQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRYACTGANGASEGCGFSFTKSPAGRTFETAEAEQLLRERRIGPLEGFRSKAGWPFVAEVAIVRDEENSNFKLEFDFGDDKDSEDTGEIVDFAHQQSLGPCPKCGSPVFEHGANYVCSKAVPTLAQTTPSCDFKSGQIILQQPIEREQMSKLLQTGKTDLLEKFVSNRTRRNFKAFLVWDGAAGKVNFEFEQREGKYPARKTAGAAAAKTTTAAAKKTGTAAKKTAAKTATKTAAVKKPRTVSATLKPSADLAAVIGSEPTSRPDVIKKLWDYIKANGLQDAKDKRAINADAKLKPVFGKEQISMFELAGIVGKHVS
(465) DNA topoisomerase III [Polaromonas naphthalenivorans CJ2]
5
MKTLVIAEKPSVAQDIVRALTPTAGKFEKHDEYFESDDWVITSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKPMDKTKTRLNAIVKLTKRKDIGALVNACDAGREGELIFRLIQQYAKSKHPVRRLWLQSMTPAAIRDGFAALRSDAQMLPLADAARCRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRKFVSRDYWEIHALFSAEAGEYPGKWFDPKFKRAAANADNAEPDPELKADRLWTEREARAIADAVRGQTATVTEESKPTTQAPGLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYVPVVKQTFEMLATSGMNHLAPHAATALKGNYIKPTKRIFDNAKVSDHFAIIPTLQAPSGLSEAEQKLYDLVVRRFMAVFFPNAEYLVTTRISVSVGHSFKTEGKVLVKPGWLAIYGKEAAAEVPEAKEGDKGQSLVPVKPGERVGVEAADAKALKTRAPARYSEATLLGAMEGAGKTIDDDELREAMQEKGLGTPATRAATIEGLIAEKYMLREGRELIPTAKAFQLMTLLRGLDVQELSKAELTGEWEFKLAQMEHGKLSRETFMAEIAAMTKNLVAKAKGYSRDSVPGDYATLQARCPNCGGVIKENYRRYTCTGATGDGEGCGFSFGKTPAGRTFELAEVEQFLRDKKIGPLEGFRSKAGWPFTAEMVLKFDEETKNYKLEFDFGDDKNADTGEIVDFGDQESLGACPKCAANVYELGKNYVCEKSVPTLEQPTPSCDFKTGQVILQQPIEREQMSKLLATGKTDLLDKFVSMRTRRAFKAMLVWDAEAGKVNFEFAPSKFPPKPGAAPRAGAGTIKTPFGKTVAVKAAAAPAAKKAAVKKVAAKKSAAASDKPKAVRKAAAPGAGLKPSDALAAIIGSEQVARPQVIKKLWDYIKDQNLQDPANKRAINADAKLLPVFGKPQVTMFELAGIVGKHLS
(673) DNA topoisomerase III [Acidovorax sp. JS42]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFEKHEDHFENERYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKQARRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFENLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGEYLGKWFDPKWKKSDDPEARADRVWSYHQAKDIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFGMLAGSGMRHLAPFAQQALDDGYVRPSKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLDVQELCRADLTGEWEFKLAQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRYACTGANGAGEGCGFSFTKSPAGRTFETAEAEQLLRDRRIGPLEGFRSKAGWPFVAEVTIARDEEAGNYKLEFDFGDDKNAEESGEIVDFAGQESLGACPSCGAPVYEHGSNYVCSKSVPTAQQPTPSCTFKSGKVILQQPVERAQMQKLLATGKTDLLDKFVSMRTRRAFKAFLAWDKEAGKVNFEFEQRESKYPPRKTAAAKTGAASARGTGAGAVKASKPATKAAAKKAAAKTTAAKTPRKASTAAGKAPSAQLAAVIGTEPVARPEAVKKMWDYIKAHNLQDPQDKRTIVADDKLRAVFGKDRIGMFELAGILGQHLA
(53) DNA topoisomerase [Acidovorax sp. JS42]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGYRGPIARLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDASTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRAQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETIARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPDCKGTLPVETGTSKRGASRPRKSGRKGS
(574) DNA topoisomerase [Acidovorax sp. JS42]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGYRGPIARLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSAGGQTFTAQWVAPDASTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPTLAPIMGQLDRAQRSRAWNDSKVTAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTIAELSCGQQKLVATGKQVAAQGWHLVLAEPQADEDGETTARSQVLPALREGLACQVAEAEVKALKTLPPKPYTQGELVKSMKGVARFVTDPRLKQKLKDTTGIGTEATRANIITGLLTRGYLVKKGRSIRASDAALTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIVQYGSTSLSIKVPQGPACPQCGAPTRQRTGKTGPFWSCSRYPDCKGTLPVETGTSKRGASRPRKSGRKGS
(727) DNA topoisomerase [Acidovorax sp. JS42]
4
MRVFLCEKPSQGKDIARVLGAGHRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGDQYKRWAIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYHGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYMGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAVDVLLSHAGRSFTASWIPPEGSTDAAGRCLQQPVAQQAADCIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPAVLDALLATDPSLRPLIGQLDRNQRSRAWNDGKVTAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQFSCGSQSLAAVGKQIAVTGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLKALKTLPPKPYTQGELIKAMKTVAKFVTDPRLKQKLRDTTGIGTEATRANTINGLIGRGYLVKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMALDTFIEKQSVWVGQLVQQYRGATLSLKLPPAPACPQCGAPMQQRTGKSGAFWSCSRYPDCKGTLPIESPTGRRSAPRKRCAASKAS
(1766) DNA topoisomerase III [Acidovorax avenae subsp. avenae ATCC 19860]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKLARRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLNKPVRRLWLQSMTPQAIRDGFGNLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRQFVSRDYWEIHAGFHAEAGEYLGKWFDPQWKKVADDPEARADRVWSFERAREIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKDTFGMLATSGMRHLAPYARQALDENYVRPSKRIFDNAKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYMVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEYAEAKALKTKPPARYSEATLLGAMESAGKQVEDEELRSAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTERMVKKAKEYDRDTIPGNYATLSTPCPNCGGVVKENYRRYACTGADGRGDGCGFSFTKSPAGRTFEPAEAEALLRERRIGPLEGFRSKAGWPFTAEVTIVRDEEAGNFKLEFDFGDDRAGEASGELVEFTDEPLGPCPICGAPVHEHGSNYVCSKAVPTAAQPTPSCTFKSGKVILQQPVEREQMAKLLATGKTDLLDKFVSMRTRRNFKAFLAWDKEAGKVNFEFEPRESKFPPRKFAGKAGAAAGAAKAGTAAAAKKAAKPAAKAAAKKSSTAAKAPRKTAAGKPPSAALAAVIGPEPVGRPEAVKKMWEYIKAHNLQDPKDKRTINADAKLREVFGKESAGMFELAGILGKHLQGDSE
(169) DNA topoisomerase III [Acidovorax ebreus TPSY]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFEKHEDHFENERYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKQAKRKDVTELVNACDAGREGELIFRLIEQYAGGAKGTLAKPVRRLWLQSMTPQAIRDGFENLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGEYLGKWFDPKWKKSDDPEARADRVWSHHQAKDIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFGMLAGSGMRHLAPFAQQALDDGYVRPSKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLIKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLDVQELCRADLTGEWEFKLAQMEKGQLSREAFMQQIQAMTEKLVKKAKEYDRDTIPGDYATLSTPCPNCGGVVKENYRRYACTGANGAGEGCGFSFTKSPAGRTFETAEAEQLLRDRRIGPLEGFRSKAGWPFVAEVTIARDEEAGNYKLEFDFGDDKNAEESGEIVDFAGQESLGACPSCGAPVYEHGSNYVCSKSVPTAQQPTPSCTFKSGKVILQQPVERAQMQKLLATGKTDLLDKFVSMRTRRAFKAFLAWDKEAGKVNFEFEQRESKYPPRKTAAAKTGAASARGTGAGAVKASKPATKAAAKKAAAKTTAAKTPRKASTAAGKAPSAQLAAVIGTEPVARPEAVKKMWDYIKAHNLQDPQDKRTIVADDKLRAVFGKDRIGMFELAGILGQHLA
(383) DNA topoisomerase [Bordetella bronchiseptica RB50]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESDRYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIVQFAGVKKPIQRLWLQSMTQQAIRDAFANLRDDEQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNERENRIRSFVSRDYWEVHATFVAAAGLYEGRWIDPAFKKDERDPEKRESRLWSLAAAQSVVAACRAQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYINTVRQTMQVLAQGDSNAVGALSRHADTVLAQNWVKPNRRIFDNKKVSDHFAIIPTLQVPRDLSEAEGKLYDLVLKRFLAVFFPAAEYRVTTRLTEVQGHRFKTEGKVLVTPGWLAVYGKEAQGEDANLVPVADGETVRAEDVEAVGLATKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEAYLRRDGRDLVPTAKARQLMTLLSGLDVSELTSPELTGEWEHKLKQIEQGALDRAAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRFACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISGEYKLEFDFGQNDEEDNEAVDFSGHTSVGACPKCSARVFEHGMSYVCEKSVGPQKSCDFRSGKVILQQEISREQMEKLLTAGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRGDKPGRPGAAAKKAAGKTATKTAAKAPAKTAAKKAVKKAAPKKAATKTAARKAAKKSAA
(1307) DNA topoisomerase [Bordetella pertussis CS]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESDRYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIVQFAGVKKPIQRLWLQSMTQQAIRDAFANLRDDEQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNERENRIRSFVSRDYWEVHATFVAAAGLYEGRWIDPAFRKDERDPEKRESRLWSLAAAQSVVAACRAQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYINTVRQTMQVLAQGDSNAVGALSRHADTVLAQNWVKPNRRIFDNKKVSDHFAIIPTLQVPRDLSEAEGKLYDLVLKRFLAVFFPAAEYRVTTRLTEVQGHRFKTEGKVLVTPGWLAVYGKEAQGEDANLVPVADGETVRAEDVEAVGLATKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEAYLRRDGRDLVPTAKARQLMALLSGLDVSELTSPELTGEWEHKLKQIEQGALDRAAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRFACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGCISKMGRPFAAILRISGEYKLEFDFGQNDEEDNEAVDFSGHTPVGACPKCSARVFEHGMSYVCEKLVGLQKSCDFRSGKVILQQEISREQMEKLLTAGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRGDKPGRPGAAAKKAAGKTATKTAAKAPAKTAAKKAVKKAAPKKAATKTAAKKAAKKSAA
(1614) DNA topoisomerase [Verminephrobacter eiseniae EF01-2]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENERYVVTSAVGHLVEIQAPEQFEVKRGKWSFAHLPVIPPYFDLKPVDKTKGRLNAVVKQARRRDVGALINACDAGREGELIFRLIEQYAGGDKPLGKPVERLWLQSMTPQAIRDGFAALRPEQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRQFVSRDYWEVHALFGAAAGPYPGKWFNPQWKKSDDAEARAERLWSVAEAQAIAQAVRDQPASVSEESKPSTQAAPPLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVARQTFEMLAGSAMRHLAPHALTALNNGYVRMSRRIFDSSKVSDHFAIIPTLQAPGGLNDAEQRLYDLVVRRFIAVFFPNAEYTVTTRISTVSVAPNGGAAAVHRFKTEGKVLVKTGWLAVYGKEAADEVEGGKEGDKGQNLVPVQPGERVLTLQADPRGFKTKPPARYSEATLLGAMESAGKQLDDDELREAMQAKGLGTPATRAAIIEGLLTEKYMLREGREIIPTAKAFQLMLLLRGLQVEELCRADLTGEWEFKLAQMEKGQLSRAAFMADIAAMTERMVTKAREYDRDTIPGDYATLQAPCPNCAGVVKENYRRYACAGKDGASPCGFSFGKSPAGRTFETAEAETLLRERKIGPLEGFRSKAGWPFSSEIVIRYDEQTHNYKLEFDFGDDRKNAEESGALVEFKDAALGPCPLCGAGVHEHGNNYLCSKSVPTAAQPAPSCSFKSGRVILQQPVEREQMQKLLATGKTDLLDKFVSMRTRRAFKAHLVWDPAAGKVNFEFAPSKFPPRQPVAAAAKTSAHVGHAGHAGRAGSALKADRAVAAKKAPVKRVAAKVKAAAAKPPRKAA
(1287) DNA topoisomerase [Polynucleobacter necessarius subsp. asymbioticus QLW-P1DMWA-1]
5
MDNPKALIIAEKPSVANDIAKALGGFIKHEDYFESDDFVISSAVGHLLEIAAPEEYDVKRGKWSFANLPVVPPYFDLRPIAKTEARLKVLQKLIKRKDINSLINACDAGREGELIFRLIAQHAKASQSVKRLWLQSMTPAAIRDGFTHLRTDDEMQPLADAARCRSEADWLVGINGTRAMTAFNSKSGGFFLTTVGRVQTPTLSIVVEREELIRKFVSKDYWEVKAEFIASAGIYEGRWFDPKFKKDVTEPDARENRLWSEAAAQSIVAACRGKKATVTEEAKPATQLAPQLFDLTSLQREANARFGFSAKNTLGLAQALYERHKVLTYPRTDAKALPEDYLDTVKQTMENLSEHSSEYRSFAKQILQGDPKDPKTKAGYGWIKPNKRIFDNSKISDHFAIIPTLETPKTLSEPEAKLYDLVVRRFLAVFYPAAEFRVTTRITEASGHHFKTEGRVLVNPGWLTVYGRSNQADDELVPVKEGETVQTESIAAIPLKTKPPARYTEATLLSAMESAGKWVDDDEMREAMAEKGLGTPATRAAIIEGLLAEKYMVREARELIPTAKAFQLMTLLRGLDVEELTRPDLTGSWENKLSLIEQGKMKRDTFMQEIAQMTQRIVKRAKEYDSDTIPGDYATMSTPCPHCKGPVKENYRRFACEKCGFTISKTPGGRAFEYPEVEELLREKTIGPLQGFRSKMGRPFAAIIKLSEIPEDDADYPNAGFKLEFDFGNTQDDETEAIDFTGRLALGACPKCSGAVYEDGMRYVCESNTGPNKSCDFKTGKVVLQQEISQEQVQKLLKEGKTDLLTNFKSNRTGRGFKAYLALGADGKIGFEFEAKAPKAGGAAKAPAKKRAGASAATKSVAKPKRASKAKSSSSS
(661) DNA topoisomerase [Burkholderia xenovorans LB400]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEDYEVKRGKWSFANLPVIPPHFDLNPIAKSESRLKVLTKLLKRKDVDRLINACDAGREGELIFRLIAQHAKARQPVQRLWLQSMTAGAIRDGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCSAGFYEGRWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRGQIGTVTEESKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKETLGMLKESNNYLPFAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLSVFFPAAEFKVTTRITEVVGHHFKTEGKVLVEPGWLQVYGREISGEDANLVPVQKDEKVKTDRIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLIREGRDLIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACSKCEFSISKIPGGRQFEIPEVEELLQNKTIGPLSGFRSKMGRPFSAILKLSFDDEIKNYKLEFDFGQDAGGEDGEPPDFSDQQPVGACPKCKGRVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKEPSAKTVAKTAAAKAAAEAADSESEDGGAPVAVKAAPAAKKAAAKKAPATKTAAARKAPARKTAARKTGS
(1504) DNA topoisomerase [Burkholderia xenovorans LB400]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQLKRWSIEQLPIIPQNWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSASGQSFTAQWVPPDAYTDDTGRCLQQPVAQRAAQQIRGAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVSTVLDSLLRTDPSLRPIMDQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTVANLACGQQKLAATGKQVVVKGWPLVLTEPQPDEDGDAAARSQVLPALREGLACLVADVDLKALKTLPPRPYTQGELVKSMKGVAKLVTDPRLKQKFRDTVGIGTEATRANIISGLIARGYIVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYSIASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRGASRPHRSGRQGS
(1170) DNA topoisomerase [Burkholderia sp. YI23]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDDYVISSAVGHLLEIAAPEEYDVKRGKWSFTNLPVIPPHFDLNPIAKSESRLKVLTRLMKRKDIDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIREGFANLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFIAAKGIYEGRWFDPKFKRVENDPEQRDSRLWSLAAAETVVAACRGKTGTVTEESKPSTQMSPLLLDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYLSTVKDTMTMLKESNNYLPFAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLSVFFPAAEYLVTTRITEVSGHHFKTEGKVLVEPGWLQVYGREAAGEDGNLVPVQKNESVDVEKVEAHGLVTKPPARYNEASLLSAMEGAGKLVEDEELRDAMAAKGLGTPATRAAIIEGLLGEKYMVREGRELIPTAKAFQLMTLLRGLGVEELTAPELTGQWEHKLSQMERGSLHRDQFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGSQVKENYRRFACTKCEFSISKIPGGRQFEIPEVEELLREKTIGPLSGFRSKMGRPFSAILKLALDDEIKNYKLEFDFGQDSGGEDGEPPDFSEQTPVGACPKCQSRVFEHGMSYVCENSVSNPKTCDFRSGKVILQQEIAREQMQKLLGDGRTDLLTNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEAKPGAKTAAAKRGAAADAQSDSGDESGDSDVAVAAKTTRAKPAAKKAPAKKAAVKKTAARKTG
(1385) DNA topoisomerase [Burkholderia gladioli BSR3]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDDFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDIDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAKLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWYDPKFKRDEHDPEKRDSRLWALPAAETIVAACRGQIGVVSEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKQTMEMLKESNNYLPHAKQVLDKGWVKPNKRIFDNAKISDHFAIIPTLQAPKALSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDKVAAHQLVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLIREGRELIPTAKAFQLTTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDTFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIPEVEELLQKKEIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEDGEAPDFSAQEPVGACPKCGARVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLSDGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKPGAAAKKAAAKKTAAAANEDGAGSDAAEAAVPAKKMAAAKKAPAAKKTAAAKKTPARKTGS
(1840) DNA topoisomerase III [Albidiferax ferrireducens T118]
5
MCERPGAREKLDCSQMKTLIIAEKPSVAQDIVRALTPVAGKFDKHDEHFESDSYVVTSAVGHLLEIQAPEEFDVKRGKWSFAHLPVIPPHFDLKPVDKTKTRLNAVVKLAKRKDVDQLINACDAGREGELIFRLIEQYAGGAKPLGKPVRRLWLQSMTPQAIRDGFNTLRSNEQMLPLADAARCRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRAFVSRDYWEVHATFAAQAGDYPAKWFDPQWKKAAANAAAGNLEEADPELKADRLWQQREAQAIADAVRGQTASVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYLPVVKQTFEMLSKSAMRHLAPHALTALNNNYIRPSKRIFDNSKVSDHFAIIPTLQAPSGLSEAEQKIYDLVVRRFMAVFFPNAEYQITTRISVAAGHSFKTEGKVLVKPGWLAIYGKEAVDEVTDRDGAKDGDKGQRLVPVQAGERVTAQTVEARGLKTRPPARYTEATLLGAMEGAGKTIEDDELRAAMHEKGLGTPATRASIIEGLLTQKYMLREGRELIPTASAFQLMTLLRGLDVKELSKAELTGEWEHKLALMEHGQLSRAEFMAEIAAMTERMVKQAKEYDRDTVPGNYATLTAPCPNCGGIIKENYRRYTCTGKTGAEEGCGFSFGKTPAGRTFEVAEVEQFLRDKKIGPLEGFRSKAGWPFTAEMVIKFDEESKNYKLEFDFGDDKKGEESGELIDFSGQESLGACPKCGAPVFEHGKNYVCEKSVPTDAQATPSCDFKTGQIILQQPIEREQIAKLLATGKTDLLDKFVSMRTRRGFKAMLAWDAEAGKVNFEFAPSKFPPRKTAAKSAAGASVAAKTGAARAATTGAAAKKAAKKVASPKAAAKASAKTPRKAAVKKVASPAAGLQPSAALAAVIGAEPVARPQVIKKLWDYIKANNLQDAVNKRNINADAKLLAVFGKPQVTMFELAGIVGKHLA
(1785) DNA topoisomerase [Cupriavidus taiwanensis]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAKTESRLKVLNRLIKRKDVTTLINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFAALREDEDMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKNEFDPEARESRLWSEAEAKSIVAACRDKPGTVTEESRPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKQTMDMLADSSPNYLPHAKKILAQGWVRPNKKIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKVEGVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMREIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENYRRFACTACEFSISKIPGGRQFEIEEVEELLQKKEIGPLQGFRSKMGRPFAAILKLGKDDEGHYKMEFDFGQNDDDNDGEPVDFSGQQPVGTCPKCGGSVFEHGMKYVCENSTTSPKSCDFTTGKIILQQEISREQIGKLLNEGKTDLLTGFKSSRTGRNFKAFLVKQPDGKIGFEFEAREPKAGAKSAAKAPAKAASRGTAEAEAAPATKTAAKTASKTAAKTAAAKAPAKKAAAKKAPAKTAAAKKTRAAAAGE
(1018) DNA topoisomerase [Burkholderia thailandensis E264]
5
MCYKAVVKGPASGSPGPSIHTVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDVDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDQLGTVTEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDETKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQADGKIGFEFEKKEPKPAAAKKTASKSTAAAADAAADSDDKAEKKTAPARKTAARKTPARKTGS
(1112) DNA topoisomerase [Burkholderia rhizoxinica HKI 454]
5
MRLRPICYKAFDSAHPYFPIVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDDYVLSSAVGHLVEIAAPQEYEVKRGKWSFAHLPVIPPHFDLQPIAKSESRLKLLTRLIKRKDVDRLVNACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPAAIRDGFAQLRSDQEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCATGSYEGRWFDPKFKKNEFDPEQRDSRLWSAAAAETIVAACRGQIGTVSEESKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLALAQALYERHKVLTYPRTDARALPEDYMAAVRDTLEVLKESNNYLPFAKQVLDKGWVRPNKRIFDNTKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVVGHHFKTEGKVLVAPGWLQVYGRETSGEDANLAPVAKDEKVQTDKIAAQQLTTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVEELTAPELTGEWEHKLSQMERGRLEREAFMREIARMTQTIVKRAKEYDSDTIPGDYATLKTTCPNCNGEVKENYRRFACTKCDFSISKIPGGRQFEIDEVEQLLSEKSIGPLSGFRSKMGRPFSAILKLARDEEANNYKLEFDFGQDTMGEEGEAPDFSSQEPVGQCPKCHARVFEHGMSYVCENQAAHPKTCDFRSGKVILQQEITREQMAKLLDQGRTDLLTNFKSSRTGRNFKAFLVKQKDGSIGFEFEKKEPAAKTAAKSSTRGAKANSGAGDAGPDTTQRGDSHRATSLKPAAKRATRTATATAGPAAKTTARKTPARKRAAG
(1292) DNA topoisomerase [Burkholderia multivorans ATCC 17616]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFACAAGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYIGTVKSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEYRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVQVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDEIKNYKLEFDFGQDQGGDEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMAKLLADGRTDLLPNFKSSRTGRNFKAYLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDTETVTEGADEKPAPARKTAARKTTTRKTGS
(1291) DNA topoisomerase [Burkholderia multivorans ATCC 17616]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDADMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFACAAGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYIGTVKSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEYRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVQVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDEIKNYKLEFDFGQDQGGDEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMAKLLADGRTDLLPNFKSSRTGRNFKAYLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDTETVTEGADEKPAPARKTAARKTTTRKTGS
(1646) DNA topoisomerase [Ralstonia pickettii 12J]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDEYVLSSAVGHLVEIAAPDEYEVKRGKWSFAHLPVIPPHFDLRPIAKSESRLKVLTRLIKRKDVTGLINACDAGREGELIFRLIAQHANTKLPVKRLWLQSMTPQSIRDGFGKLRSNEDMMPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKRFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKDEFDPERRDSRLWSEAEAKSIVAACRDKPGSVTEESKPSTQMSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYMGTVKQTLDMLGESSPNYLTHAKKILANQWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEYQVTTRVTEVAGHHFKTEGKVLVNPGWLVVYGREAQGEDANLVPVAKDEKVKTDKVEPVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVEELTQAELTGGWEHKLSLIERGQLERDEFMREIAQMTQQIVKRAKEYDSDTIPGDYATLSTPCPQCGHVVKENYRRFACSHCDFSISKIPGGRQFELDEVEELLTNKTIGPLQGFRSKMGRPFAAILKLAQEDGHWKMEFDFGQNDEDDGEPVDFSGQESVGHCPKCNGNVYEHGLKYVCENAVAQPKTCDFTTGKIILQQEISREQLAKLLTEGKTDLLTGFKSARTGRNFKAFLVKQPDGKIGFEFEPRGEGKGKPGAKTAAKKTTAAAKTPAAKKAPAKTAGKTAAKKAPARKKATEAETDEESTSET
(1730) DNA topoisomerase [Janthinobacterium sp. Marseille]
5
MTKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDEYVLSSAVGHLVEITVPEEYDVKRGKWTFTHLPMIPPHFALNPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQYTKAKQPIKRLWLQSMTPGAIREAFKNLRSDDEMLPLADAARCRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVRAEFICAAGIYQGRWLDTAFKKDETDPERRAERLWSKAAAESIVAACRGKQGNVTEESKPTTSMAPALFDLTSLQREANARFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYLPTVLQTLDVIAENNNYHQFAKQITDNKWVKPNKRIFDNTKISDHFAIIPTTQAPKNLSEPEQKLYDLVTRRFMAIFFPAAEFQVTTRFTEVSGHQFKTEGKVMTNPGWLAVYGKEVIDEKDPENSGTLVPVAKGEKVKTESVVANGLVTKPPARYSEATLLSAMEGAGKLIDNDGLRDAMAGKGLGTPATRAAIIEGLLNEKYLLREGREMIPTAKAFQLMTLLRGLGVNELTAPELTGEWEYKLSEMERGKISREEFMREIAQMTQVIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKTPGSRQFEIAEVEELLTNKTIGPLQGFRSKMGRPFAAVLKISRDEEIKNYKLEFDFGQNDDDENAEAVDFSGQTSLGPCPKCAGGVYELPLSYVCENSVAKPKTCDFRSGRIILQQEILPEQMSKLLNEGKTDLLPGFVSQRTRRAFKAYLVRGKDGKTSFEFEPRKEKAPAKGKAAAVADDAAEAGDDTAVAAKPAKKAAAKPAAKKAVAKKKAPAKKAAAKA
(401) DNA topoisomerase III [Polaromonas sp. JS666]
5
MKTLVIAEKPSVAQDIVRAITPTAGKFEKHDEYFESDEWLVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFEVKPIDKTRTRLNAIVKLAKRKDVGAIVNACDAGREGELIFRLIQQYANSKHPVKRLWLQSMTPAAIREGFDSLRSEKQMQGLADAARSRSEADWMVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRKFVSRDYWEIHASFLAEAGEYPAKWFDPKWKKAAANADNAEPDAELRADRVWSEREALAIAEAVRGKAATVTEESKPTTQAAGLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKALTYPRTDSRALPEDYLPVVKQTFEMLADSGMRHLAPHAATAIKGNYIKPSKRIFDNAKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFYPSAEYLVTTRISQAVGYSFKTEGKVLVKPGWLAIYGKEAADEVADAKDGDKGQSLVPVKPGEMVRAEVVEAKGLKTRPPARYSEATLLGAMEGAGKTIDDDELREAMQEKGLGTPATRAATIEGLIAEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSKAELTGEWEYKLAQMEHGKLSRETFMAEIAAMTENLVNKAKGYDKDTIPGDYTTLQTPCPNCGGVVKENYRRYTCTGKNGGDGCGFSFGKTPAGRTFETAEVEQFLRDRKIGPLEGFRSKAGWPFTAEMVIKFDEETKNYKLEFDFGDDKNGETGEIVDFGDQQSLGPCPRCAARVFELGKNYVCEKSVPTLEQPTPSCTFKTGQVILQQPIEREQMHKLLETGKTDLLDKFVSMRTRRPFKAMLAWDKEADKVNFEFAPSKFPPRKPAAAKTGVVKTPFGKTVAAKGAAGDAAPAAKKAAAKKVAAKKAPAKTAAPKVARKAATPKPGAGLKPSDSLAAVIGAEPVARTQVIKKLWDYIKAEGLQDAANKRAINADAKLLPVFGKPQVTMFELAGIVGKHLS
(1783) DNA topoisomerase [Herbaspirillum seropedicae SmR1]
5
MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDQYILSSAVGHLLEIAVPEEYDVKRGKWSFTHLPMIPPHFALNPIAKTESRLKVLSKLIKRKDVTTLINACDAGREGELIFRLIAQYTKAKQPVKRLWLQSMTPGAIREGFAHLRDDEEMLPLANAARCRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVHAEFVCAAGIYKGRWLDKGHKKDEADPEKRPERLWSKAAADSIVAACRDKPGNVTEESKPTTQMSPGLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYINTVKDTMEALAENNNYHQFSKQILKQGWVKPNKRIFDNTKISDHFAIIPTTQVPKNLSEPEQKLYDLVTRRFMAVFFPPAEFQVTTRYTEVSGHQFKSEGKVMINPGWLAIYGKQVEEDDKDKEGGGNLVAVAPGEKVKTDKVTANGLVTKPPARYTEATLLSAMEGAGKLVDSDELREAMAGKGLGTPATRAAIIEGLLNEKYLIREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLAQMERGKISRDEFMREIAQMTQIIVKRAKEYDNDTIPGDYATLKTPCPNCGGVVKENYRRFACTKCEFSMSKVPGGRQFEIAEVEELLQNRTIGPLQGFRSKMGRPFAAILKISRDEEIKNFKLEFDFGQDQAEGEGGEPVDFSEQTPLGACPKCGSGVYEMGLAYVCEKTVAKPKACDFRSSRIILQQEILPEQMAKLLNDGKTDLLPGFISQRTRRPFKAFLVRGKDGKISFEFEERKAKAPAKGKAAAADADDGADEAVAKPAAKKTATKTAAKTTATKAKAAAAKKPALRKATPKKAAAPDA
(76) DNA topoisomerase [Alicycliphilus denitrificans BC]
4
MRVFLCEKPSQGKDIARVLGAGQRSNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQYKRWAIEQLPIVPERWRVEPKVATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALGALKPSAETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAADVLLSHAGQSFTASWIPPEGSTDAAGRCLQQPVAQQAVDRIRAARDAQVVSVDTERVREAPPLPFDLGTLQEVCSRQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPAVLDALLATEPSLRPLLGQLDRNQRSRAWNDGKVTAHHGIIPTLEPAKLLAMSEKELAVYQLIRGRYLAQFLPHHEFDRTVTQLACGGQSLVAVGKQIAVIGWRQVLATPEPDAADGEEAQRSQVLPPLASGSRCGVEQVELKALRTLPPKPYTQGELVKVMKGVAKLVDDPRLKQKLKETTGIGTEATRASTIKGLLDRGYLLKKGRAIRASDAAFTLIDAVPAAIADPGMTAIWEQALDMIEAGQMTLDTFIAKQSTWVAQLVQQHRGATLSIALPPSPPCPQCGAPMRQRTGKSGAFWSCSRYPDCKGTLPVESSASKRGAPRKRRTVPKAS
(859) DNA topoisomerase III [Alicycliphilus denitrificans BC]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLAAVVRQAKRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLGKPVKRLWLQSMTPQAIRDGFEHLRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFQAEAGQYLGKWFDPKWKKSEDPEARADRVWSLKEAEAIAHAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKNTFAMLAGSGMRHLAPYAQQALDDGYVRPSRRIFDNAKVSDHFAIIPTTQAPHGLSEAEQKLYDLVVRRFMAVFFPSAEYLVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAASEVEGGKEGDKGQPLVPVKPGEMTHTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDEELRSAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLQVEELCRAELTGEWEYKLAQMEKGQLSREAFMQQIQAMTEKLVRKAKEYDRDTIPGDYATLATPCPNCGGVVKENYRRYACTGAGGSGEGCGFSFGKSPAGRTFETAEAEQLLRERRIGPLEGFRSKAGWPFTAEVTIARDEEAGNYKLEFDFGDDKNAEESGEIVDFAGQESLGRCPVCGAPVYEHGGNYVCAKAVPTAQQPVPSCSFKSGKVILQQPVERAQMHKLLATGKTDLLDKFVSMRTRRPFKAFLAWDAAAGKVNFEFEQRESKYPPRKTAAAAKTGAASARGTGAAGPKTSKPAAKKTAAAKTPRKTGAAGKTPSAQLAAVIGAEPVARPEAVKKMWDYIKAHNLQDPKDKRTIVADDKLRAVFGKDSIGMFELAGVLGRHLA
(1071) DNA topoisomerase [Herminiimonas arsenicoxydans]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAATPEAYDEQLKRWSIEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLPMYHSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIVVSLSAGVQAFTAHWVPPNACTDDAGRCLQQPVAQQAMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVTTVLDSLLKTDPSLRSIIGQLDRLQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDHTVAKLSCGGQNLAATGKQVVTPGWRQVLAEPQSEDGDGDGDTAARAQVLPALHEGLACQVADIDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGNASLSIKAPQGPTCPQCGAPTRQRSSKSGPFWSCSRYPDCKGTLPVESGSSKRAASRPRRSGRKGS
(388) DNA topoisomerase [Herminiimonas arsenicoxydans]
5
MTKTLIIAEKPSVANDIAKTLGGFTKHDDYFESDEYVLSSAVGHLVEISVPEEYDVKRGKWSFAHLPMIPPYFALNPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQYAKAKQPIKRLWLQSMTPGAIREAFKNLRSDEEMLSLADAARSRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDYWEVRAEFICAAGIYQGRWLDTAFKKDETDPERRPERLWSKAAAESIVAACRGGKPGNVTEESKPTTSMAPALFDLTSLQREANARFGFSAKNTLGLAQALYERHKVLTYPRTDSRHLPEDYLPTVLETLEVVAENNNYHQFAKQILNSKWVKPNKRIFDNTKISDHFAIIPTTLAPKNLSEPEQKLYDLVTRRFMAIFFPAAEFQVTTRFTEVSGHQFKTEGKVMTNPGWLAVYGKEVIDEKDPENSGTLVPVAKGEKVQTESVVANGLVTKPPARYTEATLLSAMEGAGKLIDDSDLRVAMTGKGLGTPATRAAIIEGLLTEKYLLREGREMMPTAKAFQLMTLLRGLGVNELTAPELTGEWEYKLSEMERGKISREEFMREIAQMTQVIVKRAKEYDNDTIPGDYATLKTPCPNCGSVVKENYRRFACTKCEFSMSKTPGSRQFEVAEVEELLTNKTIGPLQGFRSKMGRPFAAVLKISRDEEIKNYKLEFDFGQNDDENAEPVDFSDQTPLGPCPKCAGGVYEMPLSYVCENSVAKPKTCDFRSGRIILQQEILPEQMSKLLNEGKTDLLPGFVSQRTRRAFKAYLVRGKDGKTSFEFEPRKEKVPGKGKAAAVADDAEETTDAAPPKAAKKVAAKKPAAKKTVAKKKPAAKKTAA
(171) DNA topoisomerase [Leptothrix cholodnii SP-6]
5
MSKSLVIAEKPSVAQDIVRALTTTSGKFEKHAEHFENDHYVVSSAVGHLVEIRAPEEYDVKRGKWSFNNLPVVPPHFDLEPIDKSKGRLSALVKLIKRKDVTHLINACDAGREGELIFRLIEQYALGAKVGTKPVQRLWLQSMTPQAIRDGFEKLRSDAEMRGLAEAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSIVVEREEKIRKHVSRPYWEVRADFGAAAGLYEGKWFDPKFKKDDDLERRADRLWSEAEADAIAAAVRGRTGTVREEAKPSTQASPLLYDLTTLQREANGRFGFSAKTTLSIAQALYEKHKVLTYPRTDARALPEDYVPVAKETLAMIASEDLPGPLRELAQHARKALDAGYVKPVKRVFDNSKISDHFAIIPTLQAPRSLSEIEAKLYDMVVKRFIAVFYPSAEFMVTTRITEVPVAQSASQSLPKGVTSPLQFQTNGKVLVNPGWLAVYGKDAQDEDANLVPVKPGETVQAEELRISPLKTRPPARYNEATLLSAMEGAGKLIDDEELKAAMQEKGLGTPATRAQVIEGLILEKYMLREGRDLIATAKAFQLMTLLRGLAIEDLTKPELTGQWEYQLSQMEKGQLSRDAFMHGIADMAQRIVKKAKEYDRDTIPGDYATLKAPCPNCGGVVKENYRRFACVGRDANGSSGAEGSGCGFSISKIPGSRSFELHEAEAFLRDHKIGPLEGFRSKAGWPFTAELKLVRDDEINNWKLEFDFGEDAKKDDESGEPVDFSAQTSLGSCPKCKGHVYEHGTSYVCEHAVGAPQTCDFKTGKIILQQPVTHEQMNKLLIEGKTALLDGFVSNKTKRKFKAFLVFDKKEGKVVFEFEPRAARVPAKKAAAKAS
(694) DNA topoisomerase [Methylibium petroleiphilum PM1]
5
MACGTALRSGDNDIENMSKALVIAEKPSVAQDIVRALTPTSGKFEKHDDHFENEHYVVTSAVGHLVEIKAPEEYDVKRGKWSFAHLPVIPPHFDLAPIDKAKSRLNAVVKQVKRKDVGELINACDAGREGELIFRLIVQYAGTEKKPIDKPVRRLWLQSMTPQAIRDGFERLRSDADLRGLADAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSIVVEREEKIRKHVARDYWELKATFAAQAGEYEGKWFDPAWKKNDDAERRADRLWNEADAQAIAQAVRGQPATVTEESKPSTQSSPQLYDLTLLQREANSRFGFSAKTTLSIAQALYEKHKVLTYPRTDSKALPEDYVGVVKQTMEMLAAEDLPGPLKALSAHARKAVKEGYVKPNKRIFDNAKVSDHFAIIPTLQAPKSLTEVEAKLYDLVVKRFLAVFYPPAEFLVTTRISTVKAGSAEHRFQTHGKVMVKPGWLAVYGRDVEDADATLVPVEPGEVVRTESVDVNALKTKPPARYTEATLLSAMESAGKLIDDDELREAMQEKGLGTPATRAQTIEGLILEKYMHRDGRELIPTAKAFQLMTLLRGLQVEELTQPELTGNWEYQLAEMEKGKLSRDAFMREIAAMTQKIVAKAKEYDRDTIPGDYATLKTPCPKCGGVVKENYRRFTCAAKSGDAEGCGFSISKIPGGRSFELDEVESFIADKKIGPLEGFRSKAGWPFTAELKLAYDDEIANWKLEFDFGDDAKKGEGDGTPVDFSAQQSLGACPKCKGHVYEHGSSYVCEHAVGAHVTCDFKSGKIILQQPVAREQMTRLLQEGKTDLLENFVSNKTRRKFKARLAWDAKEGKVGFEFEPRAAKVPAKKSGVRAGTKS
(204) DNA topoisomerase [Methylibium petroleiphilum PM1]
4
MRVFLCEKPSQGKDIARVLGAGQRGNGCYSGAGVVVTWCIGHLVEAVPPEGYGEQYKRWAIEQLPILPERWRVEPKAATAAQFKVVQQLVAKAGELVIATDADREGEMIAREIIDLCGYRGPIQRLWLSALNDASIRKALGALKPSDETLPLYFSALARSRADWLIGMNLSRLFTLLGRQAGYTGVLSVGRVQTPTLKLVVDRDREIARFVCVPFWAIEVALSHAGQSFVASWTPPQGSADDADRCLQQPVAQQAAEFLRAAGTAQVLSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMLAEVPTVLNSLVKTDPSLRPLIERLDRQQRSRAWNDGKVSAHHGIIPTLEPANLSAMNEKELAVYRLIRAHYLAQFLPHHEFDRTVAQFSCGSQSLAAVGKQIAVIGWREVLATPGPDDADGEDAQRSQVLPALHAGLSCPVGKVDLKALKTLPPKPYTQGELIKAMKTVAKLVTDPRLKQKLRDTTGIGTEATRANIINGLIGRGYLVKKGRAVRASDAAFTLIDAVPSAIADPGTTAVWEQALDMIEAGQMTLDTFIEKQSVWVGQLVQQYRGATLSLKLPPAPACPQCAAPMQQRTGKSGAFWSCSRYPDCKGTLPIESPTGRRSAPRKRRAASKAS
(1223) DNA topoisomerase [Burkholderia phytofirmans PsJN]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEDYEVKRGKWSFANLPVIPPHFDLNPIAKSESRLKVLTKLLKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTAGSIRDGFARLRSDEEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCSAGFYEGRWFDPKFKRDEFDPEKRDSRLWALPAAETIVAACRGQIGTVTEESKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMDTVKETLGMLKESNNYLPFAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVVGHHFKTEGKVLVEPGWLQVYGREISGEDANLVPVQKDEKVKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLIREGRDLIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACSKCEFSISKIPGGRQFEIPEVEELLQNKTIGPLSGFRSKMGRPFSAILKLSLDDEIKNYKLEFDFGQDAGGEDGEPPDFSDQQPVGACPKCKGRVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLEEGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKEPSAKTAAKTAAAKSAAKAAPEAESDDGEVSVAVKAAPAAKKAAAKKAPATKTAAAKKAPAKKAAGRKTGS
(555) DNA topoisomerase III [Thiomonas intermedia K12]
7
MRLIIAEKPSVAQAIADVIGGVRRGDGYIDCPQAKTRVTWCFGHLLEQARPEDYVNGGKVLASHLPVIPTAWKLAPRDGGAGKQIKAIRDLLKDATEVVNAGDADREGQLLVDEVLLFLNWKGKTTRLWLSSLDDESVRRALVTVKSNDALRPLYESALARQRADWLMGMNASIALSRNLQACGVQGAWSVGRVQTPTLALLVDRQRDIQNFKPRDHYQVQATLDGDIRALWQIPEDLQTDDGLLLDKSAAETCAQAVQGQRATVAAFTRKAGERQAPMPYALSTLQKTASSRLGLSAKDTLAAAQELYEAKLATYPRSDCPWLPVEMHAAAAQIIRALGAAEMAGIDPERRHPAWNTAKVEAHHGIIPTGRGLAEVSGLSENAKKIYGLLRESYLRLFMPPETFETREALFTFPGAERFKASARIVQESGWTQLGQADNSAEDDETGQVARLPILTEGQQLACESAQVLAKRTSPPKPYTDGTLIAAMTGVHKLVTDPKLKARLKETSGLGTEATRASMIEVLIAREYAERKKKEIHPTERGVQLIDMLRKVAPDLADPGTTALQEDALAAIASARSTFDEFMTAQIDAVRESTQKLLGGQLGATPAILHACPACGGGRCAQRTSKAGATYHRCLDCDAAFGDDGGKPGKRFEDKHQSEGAAAKAPASGPKCLSCKKPTFKNETKTGKPYYRCGGCKGAWWPDRKDEGKLGTKWEERAGARA
(1850) DNA topoisomerase [Thiomonas intermedia K12]
5
MSKTLVIAEKPSVAQDIVRALTPQSGKFDKHDEYFENEQYVVTSAVGHLVEIKAPDDFEVKRGKWSFAHLPVIPPHFDLNPIEKTKSRLAAVVKQLKRKDVTALVNACDAGREGELIFRLILQYAEGKKALDKPVKRLWLQSMTPQAIREGFERLRGDADMRPLADAARSRSEADWLVGINGTRAMTAFNSKDGGFFLTPVGRVQTPTLSIVVTREEQIRKHIAREYFEVHAQFGAPAGAYAGKWFDPAFKRGEDADARADRLWDKARAEAIVAACNGQPATVRDESKPSTQLSPALFDLTSLQREANGRFGFSAKTTLGLAQALYEKHKALTYPRTDSRHLPEDYLAVARQTAQALAEAGGAIAPHARRALEADYIRPSKRVFDNAKVSDHFAIIPTTQTPGALTEAEAKIYDLVARRFLAVFFPAAESLVTTRISTVGAHQFKTEGKILVKPGWLEIYGKEEQGADDNLPAVKEGDAVQAETVELKTLKTRPPARYSEATLLGAMENAGKMVEDEELAEAMSGKGLGTPATRAATIEGLLAEAYMVREGRELIPTAKAFQLMTLLRGLQVEELTKPELTGGWEHKLAQMERGQLSREAFMRDIAGMTETIVRRAKEFDRDTVPGDYATLQTPCPNCGGVVKENYHRYACTQCDFSIGKHPGGRSFELAEVEQLLRDKHLGPLTGFRSKMGRPFAAELKLAQEDGKGQWKLEFDFGDSAPGSDGGEAPDFSSQQPLGACPKCGSAVYEAGSSYVCEKSVGPAPSCDFRSGKIILQQPIEPEQMRKLLETGRTDLLDGFVSARTKRKFKAFLVKQTGGKIGFEFEPRPAKAPAKKAAAKKATA
(1673) DNA topoisomerase [Thiomonas arsenitoxydans]
7
MRLIIAEKPSVAQAIAGVIGGAKRSDGFIDCPQAKTRVTWCFGHLLEQAKPEDYVDGGKVLASHLPVIPTTWKLSPRDGGAGNQVKVIRDLLKDATEMVNAGDADREGQLLVDEVLLFLNWKGKTSRLWLSSLDDASVRKALSSIKDNAAMRPVYESALARQRADWLMGMNCSIALSRNLQACGMPGAWSIGRVQTPTLALLVDRQREIGHFKPRDFYQVVALLDGGIRAAWQTRDDLVDEDGRLLDKARADATSHQITGKAARVTRYTRKTGERSAPLPYTLGGLQKAASSRLGLSAKDTLAAAQELYEAKVTTYPRTDCPYLPIEMHGGAAGILKAIGGTDIAGIDPERKHAAWNTAKVEAHHGLIPTGQSPDAAGLSADAKRVFGLIRESYIRLFIPPEKFETREAIFDIDGLTFRAAARVVLDPGWTKLGGRDEDEGQEQGEAQGALPDLREGEARTCERGEVVAKRTTPPKPYTDGTLIAAMTGVHKLVTDPKLKARLKETSGLGTEATRASMIETLIAREYAERSKKEIHPTDRGAQLIDMLRKVAPEVADPGYTALQEDALADIAAGRAPLAAFMRAQVDATREFSRTLLDGRLTDQSIAMHACPACGGARCAKLTSKAGNAYHRCMDCQAAFGDAGGKPGKRFEDRPQGDGAQKTSSAAATGPKCPICKKPTFKNETKTGKAYYRCGGCRVAWWPERKDESKLGTKWEAMK
(911) DNA topoisomerase [Thiomonas arsenitoxydans]
5
MSKTLVIAEKPSVAQDIVRALTPQSGKFDKHDEYFENEQYVVTSAVGHLVEIKAPDDFEVKRGKWSFAHLPVIPPHFDLNPIEKTKSRLAAVVKQLKRKDVTALVNACDAGREGELIFRLILQYAEGKKALDKPVKRLWLQSMTPQAIREGFERLRGDADMRPLADAARSRSEADWLVGINGTRAMTAFNSKDGGFFLTPVGRVQTPTLSIVVTREEQIRKHIAREYFEVHAQFGAPAGAYAGKWFDPAFKRGEDADARADRLWDKTRAEAIVAACNGQPATVRDESKPSTQLSPALFDLTSLQREANGRFGFSAKTTLGLAQALYEKHKALTYPRTDSRHLPEDYLAVARQTAQALAEAGGAIAPHARRALEADYIRPSKRVFDNAKVSDHFAIIPTTQTPGALTEAEAKIYDLVARRFLAVFFPAAESLVTTRISTVGAHQFKTEGKILVKPGWLEIYGKEEQGADDNLPAVKEGDAVQAETVELKALKTRPPARYSEATLLGAMENAGKMVEDEELAEAMSGKGLGTPATRAATIEGLLAEAYMVREGRELIPSAKAFQLMTLLRGLQVEELTKPELTGGWEHKLAQMERGQLSREAFMRDIAGMTETIVRRAKEFDRDTVPGDYATLQTPCPNCGGVVKENYHRYACTQCDFSIGKHPGGRSFELAEVEQLLRDKHLGPLTGFRSKMGRPFAAELKLAQEDGKGQWKLEFDFGDSAPGSDGGEAPDFSSQQPLGACPKCGSAVYEAGSSYVCEKSVGPAPSCDFRSGKIILQQPIEPEQMRKLLQTGRTDLLDGFVSARTKRKFKAFLVKQTGGKIGFEFEPRPAKAPAKKAAAKKATA
(99) DNA topoisomerase [Burkholderia phymatum STM815]
5
MGTKPGWENPRYRPESTNLFSVMSKALIIAEKPSVANDIARALGGFTKHDEYFESDDFVLSSAVGHLLEIAAPEEYEVKRGKWSFANLPVIPPHFDLNPIAKSESRLKVLNKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIREGFAQLRTDAEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAEFVCASGFYEGRWYDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRGQTGNVTEESKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLETVKHTMEMLKESNNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKALSEPEQKLYDLVVKRFLAVFFPAAEYRVTTRITEVVGHHFKTEGKVLVEPGWLQVYGRETGGEDANLVPVQKDEKVKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLDVKELTAPELTGEWEYKLSQMERGKLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACTKCEFSMSKIPGGRQFEIEEVEELLQKKQIGPLSGFRSKMGRPFSAILKLSFDDETKNFKLEFDFGQDQGGEDGEAPDFSEQQPVGACPKCSGKVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLENGRTDLLTNFKSSRTGRNFKAFLVKQNDGKIGFEFEKKEPKEGAAKTAAAKAAAKAAPESATGEAANEATPVKKAATKTAAAKKAPAKKAAAKTSAAKSAARKTGS
(370) DNA topoisomerase [Burkholderia glumae BGR1]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDLLINACDAGREGELIFRLIAQHAKAKQPVRRLWLQSMTPAAIRDGFAKLRSDEDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWYDPKFKRDEHDPEKRDSRLWSLPAAETIVAACRGQIGVVSEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKGWVKPNKRIFDNTKISDHFAIIPTLQAPKALSEPEQKLYDLVVKRFLAVFFPAAEYKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDKIAAHALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVRELTAPELTGEWEYKLSQMERGNLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEDGEAPDFSTQEPVGACPKCQARVFEHGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLSDGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKPGAAAKKTAARAAANEDGAARETEDGAAPAGKTAAKKAPAAKKAPAAKKAPAAKKTPARKTGS
(412) DNA topoisomerase [Burkholderia glumae BGR1]
3
MRLWIFEKPSMAKAVIPHLPKPHTRHEGYYETGDGYVSWLAGHVMEQVQPGDYDERWGKFPWAFEDLPIIPKDWKLKVSEDKKGQVKIIETLLKKCTSIVNGGDADREGQLLVDEVLLHFGNTKPVARIHLSAMDPTSVKKAIASLEDNATFRPLYEAGLGRQRADWLVGMNMSRAYTILAKKQNYPGVLSVGRVQSPTLALVVKRDREIDGFVPKDFWTVEAQFADPGQSALPFWSRWLPPGLSLESAEKQADVDAKGEADEDEEGDEIEGEGGTVTGQRPAWLDEQNRIINKAVADQIAANVQAAGQGTVTRYVNKPAEEQPPLPFELTGLQTALNGKYGYSAKEVLDTCQELYLQGHTTYPRSDCPYLPVSQHAEAPDVLDAIARGAPHLASLAANANVTIRSRVWNDSKVTEHHALIPTRQAPDWSTMTEIKRRTYEMIAQRYLAQLYPNCQVDKAKVEVSIAGERFAASGRVVKDPGWRVVFQGEAQATDAKKAKDATPTLPVLTEQGPVNRLAVRVDAKRTTPPPRYTEGSLLTAMKHVHRTVTDPVERKKLKALDGIGRSATRAGIIEMIIKRGFVEVKGKQLVATVVGKILVDALPAKLTDPGMTARWEALLDAIAKKQIPLHAFMAKQEEAIGELVAAARVSTLPTIPPDAMPARKPYTGSSTPRPAPDGAKKCPKCKKGYLVPRTVKNGPKAGQTFHGCNNYPECKHSVWPK
(1240) DNA topoisomerase [Burkholderia ambifaria AMMD]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYFESDEFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDTDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVKAAFACANGFYEGKWYDPKFKRDEFDPERRDSRLWSLPAAETIVAACRDQVGTVSEESKPSTQLSPLLFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYISTVQSTLEMLKESHNYLPHAKRVLDQGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDMVVKRFLAVFFPAAEFRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLQTPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIAEVEELLQQKTIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGEEGEAPDFSEQEPVGACPKCNGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITRDQMAKLLADGRTDLMPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDAETVTEGADEKPAPARKTAARKTTARKTGS
(1213) DNA topoisomerase [Burkholderia vietnamiensis G4]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEFVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLMKRKDVDRLINACDAGREGELIFRLIVQHAKAKQPVQRLWLQSMTPQAIRDGFAHLRSDNDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFACAAGFYEGKWFDPKFKRDEFDPEKRDSRLWSLPAAETIVAACRDQIGTVSEESKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLATVQSTLEMLKESHNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFRVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVQVQKDEKVKTDEIAAVALVTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLGRDAFMQEIARMTQQIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIAEVEELLREKTIGPLSGFRSKMGRPFSAILKLSFDDETKNYKLEFDFGQDQGGDEGEAPDFSAQEPVGACPKCNGRVFEHGMSYVCEHSVANPKTCDFRSGKVILQQEITREQMAKLLADGRTDLLPNFKSSRTGRNFKAFLVKQPDGKIGFEFEKKEPKAAAAKKTAKSATKDAETVTEGADEKPAPARKTAARKTTARKTGS
(1414) DNA topoisomerase III [Burkholderia vietnamiensis G4]
3
MKRLFIAEKPAMARDIAKHMGGRMTKKVGYVEVDMGGGVVNIVASCIGHLLKQAEPADYVKDLEFPGTFADLPILPDQWKLQIAEKKSAQVTLLRRLLRECDEVVNAGDPGREGQLIIDELLEFCGNRKPVKRILLNSLDSATVKRELANLQDNTRFKPIYQAGLGRQRADWLVGMNLSRAYTILGRRAQYRGVLSVGRVQSPTLALVVRRDRAIETFVPRDYWAVKALVRVDGGEFWARWKKPEPAPEWLDEEGRIVVQAEAERIVRATQGQTGQITRFETKPGKEEPLLPFSLATLQIFASAKWGYSAKEVLDACQYLYSEKKCFSYPRTDARHLVVALQAQIPDTLSAIAQTLSMLSPACAKADSSILGKAWDDSKVGEHYALIPTSEAADFASLTPIQQNLYRAVAQRYITLFYPDCLIERTSVEATVAQEVFAASGRVVKSEGWREVYAGEAPEPETPDANGKVAEEKEDEQRFPQMSLGQSAKAAQTVSEQKRTKPPTRMSDSSLLLAMTNVHQLVKDPQLRQRLQSSKGIGTSATRAAIIENLVEKGLLLREGKTLISSSAARVLIDALPATLLDPALSAMWENALDLVAAGKAPLDLFMQKQEAWLRQLLEKAQATGLGALSDAPLANANAGGASRGSGSGSRAGSSSGGSRSAGTSRSSSGSTASSRSAPQTGAGQNAGSGSRTPAPREIGHESSKTAPSAAVKACPECKTGKMVVRQARSGPSAGKPFLGCTNYPRCKHAERMPEKEPAR
(968) DNA topoisomerase [Burkholderia mallei ATCC 23344]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDMDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDHLGTVTEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKGEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIAEVEELLRKKEIGPLSGFRSKMGRPFSAILKLTFDDETKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQTDGKIGFEFEKKEPKPAAAKKTAARSSAAADDAAADSGEKAEKKAAPARKTAARKTPARKTGS
(1544) DNA topoisomerase [Ralstonia solanacearum Po82]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYYESDDHVLSSAVGHLVEIAAPDEYEVKRGKWSFAHLPVIPPHFDLRPIAKSESRLKVLTRLIKRKDVTSLINACDAGREGELIFRLIAQHANTKLPIRRLWLQSMTPQAIRDGFAQLRSDDDMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKRFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKNEFDAEQRESRLWSEAEAKSIVAACRDKPGTVTEESKPSTQMSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYMGTVKQTLDMLADSSPNYLPHAKKILNSQWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEYLVTTRVTEVAGHHFKTEGKVLVNPGWLAVYGRQAEGQGEDANLVPVAKDEKVKTDKVEPVSLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLLREGRELIPTAKAFQLMTLLRGLGVEELTQAELTGEWEHKLAQIERGRLARDEFMREIAQMTQQIVKRAKEYDSDTIPGDYATLSTPCPQCGHVVKENYRRFACSHCDFSISKIPGGRQFELEEVEELLINKTIGPLQGFRSKMGRPFAAILKLAQEDGHWKMEFDFGQNDGDEDGEPVDFSGQESVGHCPKCSGNVYEHGLKYVCENAVAQPKTCDFTTGKIILQQEISREQLHKLLTEGKTDLLTGFKSARTGRVFKAFLVKQPDGKIGFEFEPRGEGKAGAKTAAKKTTATAKKTAAAKAPAKAPAKTAAKAAAKKTPARKKAVAEADEESTSET
(819) DNA topoisomerase [Ralstonia eutropha JMP134]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAKTESRLKVLNKLIKRKDVTGLINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFASLRADEDMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVHAEFIAAAGLYEGRWFDPKFKKSEFDPEARESRLWSEAEAKSIVAACRDKTGTVTEESKPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYMETVKQTMTMLADSSPNYLPHAKKILSQGWVKPNKKIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKVESVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVQELTQAELTGEWEHKLSQIERGRLKRDEFMLEIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENYRRFACMACEFSISKIPGGRQFEIEEVEELLLKREIGPLQGFRSKMGRPFAAILKIAKDDEGHFKMEFDFGQNDDEGDGEPVDFSGQEPVGTCPKCGGAVFEHGMKYVCENSVASPKSCDFTTGKIILQQEISREQVGKLLNDGRTDLLTGFKSSRTGRNFKAFLVRQADGKIGFEFEAREPKAGAKASGKTASRAAAETGEAEAAAAKAPAKKAAATKTATKTTATKTAAKKAPAKTVAAKKTRAAGKATVEAEE
(127) DNA topoisomerase III [Variovorax paradoxus S110]
5
MKTLVIAEKPSVAQDIVRALTPVAGKFDKHDEHFENDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPHFDLKPVDKTKTRLNAVVKQAKRKDVTQLINACDAGREGELIFRLIEQYAGGKTGLNKPVKRLWLQSMTPQAIRDGFDALRTEKQMQGLADAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRKFVSRDYWEIHGVFQAEAGQYPGKWFDANFKKPPPGPDGTADAEIRADRVWSEREAREIADAARGKPASVTEESKPTTQASPMLFDLTSLQREANGRFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVVKDTMKMLAESGMKHLAPFAQQAVDGSYVKPNKRIFDNAKVSDHFAIIPTLQAPSGLSDAEQKLYDFVVRRFMSVFFPSAEFQVTTRISTVEAGGKKYPFRSDGKVLVKPGWLAIWGKEAISDDDEKDGKNLVVVKPGETVKTESADLKALKTRPPARYSEATLLGAMEGAGKTIDDDELREAMQEKGLGTPATRAATIEGLITEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSKAELTGEWEYKLAQMEKGALSRDAFMREIAEMTQHIVKKAKEYDRDTVPGDYATLSTPCPNCGGVVKENYRRYSCTGKAGQEPCGFSFGKSPAGRTFEVAEAEVLLRDKHIGPLEGFRSKAGWPFTSEIVLKYDEEAKNWKLEFDFGDDKNADTGEIVDFSEQDTVGPCPICGAPVFEHGSNYVCEKSVPTTAQPTPSCTFKTGKIILQQPVERAQMEKLLATGKTDLLDKFVSMRTRRAFKAFLTWNAEEGKVTFEFAPREGGSKFPPRKTFGKAAPAGKTAAAKKVAAKKTPAAKKAPAAKKAAAPRKPGAGLKPSDSLAAVIGAEPVARTEVIKKLWDYIKANGLQDAANKRAINADAKLKPVFGKDQVTMFELAGIVGKHLSAP
(1054) Candidate type IA DNA topoisomerase [Ramlibacter tataouinensis TTB310]
5
MSKTLIIAEKPSVAQDIVRALTPVAGKFDKHDEHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKGRLNAVVKLAKRKDVTELVNACDAGREGELIFRLIEQFAGGGNPLGKPVRRLWLQSMTPQAIRDGFEQLRTDRQMEGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLAVVVEREEQIRRFVSRDYWEIHASFLAEAGEYPGKWFDPKWKKNPDDAEQKADRVWTLQEAQAIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGRFGYSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLGTVKQTMQMLAASGMRHLAPFAQQAIDGNYVKPTRRVFDNSKVSDHFAIIPTLQAPSGLSDAEQKLYDLVVRRFLSIFFPSAEHLVTTRINQVVGHHFKTEGKVLVKPGWLAIWGKEADVEGDENSKTLVPVKPGEMVRTESVEARGLKTRPPARYSEATLLGAMEGAGKLVEDDELREAMQDKGLGTPATRAAIIEGLINERYMFREGRELIPTAKAFQLMTLLRGLGVEELSRPELTGEWEYKLAQMERGQLSRDAFMQEIAEMTKHIVKKAKEYDRDTVPGDYATLKTPCPNCGGVVKENYRRYSCVGRKGDGSDACGFSFTKIPAGRAFELHEVEQFLRDKRIGPLEGFRSKAGWPFTAEIALKYGEEEKNWKLEFDFGDEQDPSETGELVDFGAQQPLGPCPKCAARVFEFGKNYVCERSVPTPQQPTPSCDFKTGQIILQQPVEREQMQKLLATGRTDLLDKFVSMRTRRPFKARLAWDAEAGKVNFEFEPRESKFPPRKGAGAARPATGKTAPRKAAVGRKAGAAIPADKGTAAAKKAAGAKPVAAAKKAAAPKAPRKTGPGLTPSPQLAAVVGAEPVARTEVIKKLWDYIKANGLQDAANKRAINADAKLAAVFGKPQVTMFELAGIVGKHLS
(1716) DNA topoisomerase III [Acidovorax citrulli AAC00-1]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHEDHFENDRYVVTSAVGHLVEIQAPEEFDVKRGKWSFAHLPVIPPYFDLKPVDKTKSRLNAVVKLARRKDVTELVNACDAGREGELIFRLIEQYAGGAKGGLNKPVRRLWLQSMTPQAIRDGFGNLRSDQQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRQFVSRDYWEIHAGFHAEAGEYLGKWFDPQWKKVADDPEARADRVWSFERAREIADAVRGKAATVTEESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKDTFGMLATSGMRHLAPYARQALDENYVRPSKRIFDNAKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYLVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDGKAGDKGQPLVPVKPGEMTHTEYAEAKALKTKPPARYSEATLLGAMESAGKQVEDEELRSAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTTKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTERMVKKAKEYDRDTIPGNYATLSTPCPNCGGVVKENYRRYACTGADGRGDGCGFSFTKSPAGRTFEPAEAEALLRDRRIGPLEGFRSKAGWPFTAEVAIVRDEEAGNFKLEFDFGDDRAGEASGELVEFTGEPLGPCPICGAPVHEHGSNYVCSKAVPTAAQPTPSCTFKSGKVILQQHVEREQMAKLLATGKTDLLDKFVSMRTRRNFKAFLAWDKEAGKVNFEFEPRESKFPPRKFAGKAGAAAGAAKAGTAAAAKKAAKPAAKAAAKKSTAAAKAPRKTAAGKPPSAALAAVIGPEPIGRPEAVKKMWEYIKAHNLQDPKDKRTIKADAKLREVFGKESAGMFELAGILGKHLQGDSE
(1283) DNA topoisomerase [Acidovorax citrulli AAC00-1]
4
MRVVLCEKPSQGKDIARVLGARQREAGCLAGPGIKVTWGIGHLIEAAPPEAYGEHFQRWSLETLPIVPQQWRWVVKADTASQFKVVQRLLAQASELIIATDADREGEMIARELIEYCGYRGPIQRLWLSALNDASIRKALGALRASHETLPLYHCALARSHADWLVGINLTRLFTLLGRKAGFDGVLSVGRVQTPTLKLVADRDREIAAFVPVPFWSIEVSLSAGAQAFSAHWVPPATVTDAAGRCLQQSAAQHAAAAVRTAGHAQVTGIDTERVQEGPPLPFDLSTLQEVCSRRLGLDVQETLDIAQALYETHKATTYPRTDAGYLPENMLTEVPTVIRSLLKTDPALQPLMQRLDLGQRSRAWNATKIAAHHAIIPTLEPADLSKMSEKELAVYRLIRAHYLAQFLPHYAYDRTMVRLACGGQALQASGKQVVDAGWKAAFAAPSIPGAGAETPEAETDSEAPRDQALPTLHEGMACEVRSLDLKSLYTKSPPPYTQGELVKAMKTVAKLVTDPRLKQTLRDTTGIGTEATRANIISGLLARGFLVRKGRVVRASKTAMTLIDAVPAAIADPGTTAIWEQALHMIEARTMDLDTFVSKQAAWVSQLVEQHREATLAIRVPAGPPCPLCGAATRKRTGKTGAFWSCSRYPDCKGTVAIDSAEAGRRNGPRKPRAARKLH
(707) DNA topoisomerase [Taylorella asinigenitalis MCE3]
5
MSKTLIIAEKPSVATDLSKALGSFKKESGYYENDQYVISSSVGHLLTLHNPDDAVRGKWSFANLPAIPKRNFEIEPIDKKSKERLTLLTKLIKRSDIESIINACDAGREGELIFRYIIQYSKTKKPIKRLWLQSMTKQAIQEAFSNLRSDQSMKPLEDSARSRAEADWLIGINGTRAMTAFNSKGGGFHKTPIGRVQTPTLAIVYDRDKKIREYEPKDYWEVIGTFVASAGVYEGKWFDPNFKKNPKDPDARESRIWDANTAKTIVLACKGKEGTVSEEIKELSQNSPILFDLTALQREANSKFGFSAKTTLAVAQALYEKHKLITYPRTDSRYLPEDYLSTVKDNLKSITSMTSSLHKDHREFAEKILKNGWVKPNKRIFNNSKVSDHFAIIPTTGNSGTLSEAEAKVYGLICKRFMAVFFPPAIYNVTTRITDVFSYKFKTEGKILVSPGWLEIYGREEMDETLPQIKPNETVLTETIESVQNKTKPPAHFNEATLLSAMEGAGKLIDSDELREAMSERGLGTPATRASIIEGLITEQYLRREGKDLITTTKTKQLMTLLHGLSINELTSPELTGEWEYKLRQIEDGNLDRQSFMQEIAKNTQVIVKRAKEYEHDTVPGDYATLMTPCPVCGGVIKENYRRYACTNCDFSITKNPGSRPFETSEVEEFLSNRTIGPLSGFISKLGRPFSAILKLTDDNKLEFDFGNDDSEEGEEIDLQALTPIGKCPKCSSDVYDTGLSYACENQIKDKSCDFKSGKVILQQEIPVEQMQKLLVEGRTDLMDKFISNRTKRAFKAYLVLEKNGKVGFEFEKKTKAANKTGKK
(1839) DNA topoisomerase [Bordetella parapertussis 12822]
5
MNKTLIIAEKPSVALDISRALGGFAREGDYFESDRYVLASSIGHLLSLVAPNDPVKGKWSFTHLPVIPPAFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIVQFAGVKKPIQRLWLQSMTQQAIRDAFANLRDDEQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVNERENRIRSFVSRDYWEVHATFVAAAGLYEGRWIDPAFKKDERDPEKRESRLWSLAAAQSVVAACRAQSGSVTEESKPSTQMSPALYDLTSLQREANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYINTVRQTMQVLAQGDSNAVGALSRHADTVLAQNWVKPNRRIFDNKKVSDHFAIIPTLQVPRDLSEAEGKLYDLVLKRFLAVFFPAAEYRVTTRLTEVQGHRFKTEGKVLVTPGWLAVYGKEAQGEDANLVPVADGETVRAEDVEAVGLATKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNEAYLRRDGRDLVPTAKARQLMTLLSGLDVSELTSPELTGEWEHKLKQIEQGALDRAAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRFACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISGEYKLEFDFGQNDEEDNEAVDFSGHTSVGACPKCSARVFEHGMSYVCEKSVGPQKSCDFRSGKVILQQEISREQMEKLLTAGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRGDKPGRPGAAAKKAAGKTATKTAAKAPAKTAAKKAVKKAAPKKAATKTAARKTAKKSAA
(1692) DNA topoisomerase [Bordetella petrii DSM 12804]
5
MSKTLIIAEKPSVALDISRALGGFAREGDYFESERYVLASSIGHLLGLVAPNDPVKGKWSFAHLPVIPPEFALGPADKRSAERLKLLVKLAKRKDVDALINACDAGREGELIFRYIIQYAGVKKPIKRLWLQSMTQAAIREAFSNLRDDAQLKPLEAAARSRAEADWLVGINGTRAMTAFNSKDGGFFKTPVGRVQTPTLAIVFEREERIRAFVPRDYWEVHATFVAAAGLYQGRWIDPDFKKDERDPEKRESRLWSQAAAQSVVAACREQPGSVTEESKPSTQMSPALYDLTSLQRDANGRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYLGTVRDTMQALAKGGSNAVGQLSRHADTIVAQSWVKPNRRIFDNKKVSDHFAIIPTLQIPHDLSEAEAKLYDLVLKRFLAVFFPAAEYRVTTRITEVQGHRFKTDGKVLVAPGWLAVYGKEAQGEDANLVPVADNETVRTEDVEAVGLSTKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAGIIEGLLGEGYLRREGRDLVPTAKARQLMTLLSGLDVTELTSPELTGEWEHKLKQIEQGGLDREAFMREIAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRYACTQCDFSIGKHPGGRTFELPEVEELLAKREIGPLQGFISKMGRPFAAILRISDEYKLEFDFGQNDDDDSEPVDFSGHTPVGACPKCSSRVFEHGLSYVCEKSVGPDKTCDFRSGKIILQQEISREQMHKLLTDGRTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRAAKTGRAPAKTASKTATKTATKTATKAASKTAAKKAAPRKTAAKKAPAKKSA
(1410) DNA topoisomerase [Bordetella petrii DSM 12804]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPQTATQFKVVKTLLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALAKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFESVPYWAIDVSLSAGGQTFTAQWVAPDASTDDAGRCLQQPVAQQAAQQIRAAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRPIMEQLDRSVRSRAWNDTKVSAHHGIIPTLEPANLSAMSEKEQAVYRLIRAHYLAQFLPHHEFDRTVAELFCGQQKLVATGKQVVAKGWRLVLAEPQADEDGDGAARSQVLPALRDGMACQIAGADIKALKTMPPKPYTQGELVKAMKGVARFVTDPRLKQKLKDTTGIGTEATRANIISGLIARGYIVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEGGQLTLDVFIGKQAAWISQLIAQYGSTSLSIKVPQGPACPQCGAPTRQRTGKSGPFWSCSRYPDCKGTLPVATGTSRRGASRPRRTSGGGRKGS
(1516) DNA topoisomerase [Bordetella petrii DSM 12804]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQLKRWSIEQLPIIPQNWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVSLSASGQSFTAQWVPPDAYTDDTGRCLQQPVAQRAAQQIRGAGSAQVVSVETERVREGPPLLFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVSTVLDSLLRTDPSLRPIMDQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSAMSEKELAVYRLIRAHYLAQFLPHHEFDRTVANLACGQQKLAATGKQVVVKGWPLVLTEPQPDEDGDAAARSQVLPALREGLACLVADVDLKALKTLPPRPYTQGELVKSMKGVAKLVTDPRLKQKFRDTVGIGTEATRANIISGLIARGYIVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYSIASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGTSKRGASRPHRSGRQGS
(1826) DNA topoisomerase [Bordetella petrii DSM 12804]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLSGSGVTITWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSAPFWAIDVSLSTEGQAFSAQWVAPDGCTDDAGRCLQQPVAQQAALQIRVADNTQVVSVETERVREGPPLLFDLSTLQEVCSKQLGLDVQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPAVLDSLLKTDPSLRPIMSQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSPLSEKELAVYRLIRAHYLAQFLPHHEFDRTVAEFSCGQQMLVATGKQVVVKGWRLVLAEPQADEDGDDAARSQVLPPLRGGLACQVAEVEIKALKTMPPKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQLIAQYGSMSLSIKLPHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTPKRGASRSRSSGRKGA
(1576) DNA topoisomerase [Burkholderia pseudomallei K96243]
5
MSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDMDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDHLGTVTEESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEGADANLVPVQKGEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENYRRFACTKCEFSISKIPGSRQFEIAEVEELLRKKEIGPLSGFRSKMGRPFSAILKLTFDDETKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQPDGKIGFEFEKKEPKPAAAKKTAARSSAAADDAAADSGEKAEKKAAPARKTAARKTPARKTGS
(156) DNA topoisomerase [Collimonas fungivorans Ter331]
5
MSKTLIIAEKPSVANDIAKTLGGFTKHDEYFESDEYVLSSAVGHLLEIAVPEEYDVKRGKWTFTHLPMIPPHFALNPIAKTESRLKVLNKLIKRKDVTALINACDAGREGELIFRLIAQYTKAKQPVKRLWLQSMTPGAIRDGFTHLREDKDMLPLADAARCRSEADWLIGINGTRAMTAFNSKEGGFYLTTVGRVQTPTLSIVVEREEKIKKFVPRDFWEVRAEFVCAAGIYEGRWLDTAHKKDENDPEKRAERLWSKAAAESIVAACRGKMGAVREESKPTTSMAPALFDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRHLPEDYLSTVKQALETVSENNNYQQFAAQILNKGWVKPNKRIFDNTKISDHFAIIPTTQAPKNLSEPEQKLYDLVTRRFMAVFFPAAEFQVTTRYTEVSGHQFKTEGKVMTNPGWLAIYGKEAADEKDPENSGTLVAVAKDEKVKTDKITANGLVTKPPARYTEATLLSAMEGAGKLLDDGELREAMAGKGLGTPATRAATIEGLLYEKYLLREGREMMPTAKAFQLMTLLHGLGVDELTEPELTGEWEHKLSQIERGTISREEFMREIAQLTQIIVKRAKEYDNDTIPGDYATLLAPCPNCGSVVKENYRRFACTKCEFSMSKTPGSRQFEISEVEELLTKRTIGPLQGFRSKMGRPFAAILKISRDEEIKNYKLEFDFGQNDDEGEDGEGVDFTGQTALGPCPKCGNGVYEMGLAYVCEKAVAKPKACDFRSGRIILQQEILPEQMVKLLNDGKTDLLPGFISQRTRRPFKAFLVKGKDGKVSFEFEERKAKAPPKGKAKAAAVEGEEDEVTAVAKKPAAKKPTVKKAAVKKAAPKRVVAKRKAA
(538) DNA topoisomerase III [Delftia acidovorans SPH-1]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHDEYFESEHYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKPVDKTKSRLNAVVKLAKRKDVTELINACDAGREGELIFRLIEQYAAGAKPDGKGLGKPVKRLWLQSMTPQAIRDGFQNLRSDAQMLGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHAAFDAQAGQYLGKWFDTQWKKSEDAEARADRIWNQRDAQAIADAVRGKPAQVTEESKPTSQASPLLFDLTSLQREANGKFGFSAKTTLSLAQSLYERHKALTYPRTDSRALPEDYVPVAHQTFAMLAGSGMRHLAPFAQQALDENYVRPTKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEHQVTTRISKVEQHSFKTEGKILVKPGWLAIYGKEAANEVEGGKDGDKGQPLVAVQPGEQPRAGQVDPKGLKTKPPARYSEATLLGAMESAGKQVEDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSRADLTGEWEYKLAQMEKGQLSRDAFMQQIQAMTEKLVKKAKEYDRDTVPGDYATLSTPCPNCGGVVKENYRRYGCTGSDGQGAGCGFSFTKSPAGRTFETAEAEQLLRDRRLGPLDGFRSKAGWPFVAEVTIVHDEEGGNYKLEFDFGDDAASEDTGELVDFASQQSLGPCPKCGAPVFEHGSNYVCAKAVPTLAQATPSCDFKSGQIILQQPIEREQMQKLLQTGKTDLLDKFVSNRTRRSFKAFLVWDGAAGKVNFEFEQRDSKYPPRKTAAAKSAPAKKAPAKKAAAKTTAKTATKTATKTARKPAAGTLQPSAALAAVIGEGTVARTEVVKKLWEYVKAQNLQDPKDKRVIRADDKLRPVFGKDSVNMFELAGIVGKHLTP
(88) DNA topoisomerase [Delftia acidovorans SPH-1]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLSGSGVTITWCIGHLVEAAAPEVYDAALKRWSLEQLPIIPQQWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIIDLCGYRGPIERLWLSALNDASIRTALGKLRPSSDTLPMYYSALARSRADWLVGMNLSRLFTLLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFKSAPFWAIDVSLSTEGQAFSAQWVAPDGCTDDAGRCLQQPVAQQAALQIRVADNTQVVSVETERVREGPPLLFDLSTLQEVCSKQLGLDVQETLQIAQALYETHKATTYPRSDSGYLPESMFAEVPAVLDSLLKTDPSLRPIMSQLDRSQRSRAWNDGKVTAHHGIIPTLEPANLSPLSEKELAVYRLIRAHYLAQFLPHHEFDRTVAEFSCGQQMLVATGKQVVVKGWRLVLAEPQADEDGDDAARSQVLPPLRGGLACQVAEVEIKALKTMPPKPYTQGELVKSMKGIARFVTDPRLKQKLKDTTGIGTEATRANIISVLIARGYIVKKGRSIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFLSKQAAWISQLIAQYGSMSLSIKLPHGPACPQCGAATRQRTGKSGPFWSCSRYPDCKGTLPVESGTPKRGASRSRSSGRKGA
(252) DNA topoisomerase [Cupriavidus necator N-1]
5
MLSSAVGHLVEIAAPDEYEVKRGKWSFANLPVIPPHFDLRPIAKTESRLKVLNRLIKRKDVTALINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTQQAIRDGFASLREDEDMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKSEFDPEARESRLWSEAEAKSIVAACRDKTGTVTEESKPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLDTVKQTMDMLADSSPNYLPHAKKILAQGWVKPNKKIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPAAEFQVTTRITEVAGHHFKTEGKVLVNPGWLVIYGREAQGDKDAANLVPVAKDEKVKTDKVESVGLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLTEKYLVREGRELIPTAKAFQLMTLLRGLGVLELTQAELTGEWEHKLSQIERGRMKRDEFMLEIAQMTQQIVKRAKEYDSDTIPGDYATLDTPCPQCGGQVKENYRRFACTACEFSISKIPGGRQFEIEEVEELLLKKEIGPLQGFRSKMGRPFAAILKLGKDDEGHYKMEFDFGQNDDDNDGEPVDFSGQEPVGTCPKCGGSVFEHGMKYVCENSTTSPKSCDFTTGKIILQQEISREQIGKLLTDGKTDLLTGFKSSRTGRNFKAFLVKQPDGKIGFEFEAREPKAGAKTAAKTTAKAASNGTAEAAPATKTAAKTAAKTPATKAPAKKPAAKKAPAKTAAAKKSRAAAAGE
(1114) DNA topoisomerase III [Delftia sp. Cs1-4]
5
MTKTLVIAEKPSVAQDIVRALTPVAGKFDKHDEYFESEHYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLPVIPPYFDLKPVDKTKSRLNAVVKLAKRKDVTELINACDAGREGELIFRLIEQYAAGAKPDGKGLGKPVKRLWLQSMTPQAIRDGFQNLRSDAQMLGLASAARSRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEVHAAFDAQAGQYLGKWFDPQWKKSEDAEARADRIWNQRDAQAIADAVRGKPAQVTEESKPTSQASPLLFDLTSLQREANGKFGFSAKTTLSLAQSLYERHKALTYPRTDSRALPEDYVPVAHQTFAMLAGSGMRHLAPFAQQALDENYVRPTKRIFDNSKVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEHQVTTRISKVEQHSFKTEGKILVKPGWLAIYGKEAANEVEGGKDGDKGQPLVAVQPGEQPRAGQVDPKGLKTKPPARYSEATLLGAMESAGKQVEDDELREAMQEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSRADLTGEWEYKLAQMEKGQLSRDAFMQQIQSMTEKLVKKAKEYDRDTVPGDYATLSTPCPNCGGVVKENYRRYGCTGSDGQGAGCGFSFTKSPAGRTFETAEAEQLLRDRRLGPLDGFRSKAGWPFVAEVTIVHDEEGGNYKLEFDFGDDAASEDTGELVDFASQQSLGPCPKCGAPVFEHGSNYVCAKAVPTLAQATPSCDFKSGQIILQQPIEREQMQKLLQTGKTDLLDKFVSNRTRRSFKAFLVWDGAAGKVNFEFEQRDSKYPPRKTAAAKSAPAKKAPAKKAAAKTTAKTATKTVRKPAAGTLQPSAALAAVIGEGTVARTEVVKKLWEYVKAQNLQDPKDKRVIRADDKLRPVFGKDSVNMFELAGIVGKHLA
(1196) DNA topoisomerase [Cupriavidus metallidurans CH34]
4
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQLKRWSVEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGYRGPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDACTDDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRSQRSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAKFSCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVADVDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIARGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGSSKRGASRPRRSGRKGS
(1305) DNA topoisomerase [Cupriavidus metallidurans CH34]
5
MSKALIIAEKPSVAADIARALGGFTKHDEYFESDDYVLSSAVGHLVEIAAPDDYEVKRGKWSFANLPVIPPHFDLRPIAKTESRLKVLNRLIKRKDVTALINACDAGREGELIFRLIAQQAKAKQPVRRLWLQSMTPQAIRDGFAALREDEEMLPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKHFVPRDYWEVRAEFIAAAGLYEGRWFDPKFKKNEFDPEARDSRLWSEAEAKSIVAACRDKQGTVTEESKPSTQQSPALFDLTTLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLDTVKQTMDMLADSSPNYLPHAKKILSSGWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPTAEFQVTTRITEVAGHHFKTEGKILVNPGWLVIYGREAQGKDDKDANLVPVQKDEKVKTDKVESVGLTTRPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLAEKYLVREGRELIPTAKAFQLMTLLRGLGVEELTQAELTGEWEHKLSQIERGRLKRDEFMREIAQMTQQIVKRAKEYDNDTIPGDYATLDTPCPQCGGQVKENYRRFACTACEFSISKIPGGRQFEIEEVEELLLKKEIGPLQGFRSKMGRPFAAILKLAKDDDGNWKMEFDFGQNDDEGDGEPVDFSEQTPVGKCPKCGGSVYEHGMKYVCENAVGSAKSCDFTSGKIILQQEISREQIGKLLTDGKTDLLTGFKSSRTGRNFKAFLVKQPDGKIGFEFEAREPKAGAAAKTAKPAAKSAAKAESAPAKVAAKKAPAAKKAATKTATKTAATKTAAAKKTRATTKQTAEAEE
Family distribution
Taxonomy tree
Burkholderiales